BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (416 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 465 e-129 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 454 e-126 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 440 e-122 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 436 e-120 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 427 e-118 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 419 e-116 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 418 e-115 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 417 e-115 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 415 e-114 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 415 e-114 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 409 e-113 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 407 e-112 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 402 e-110 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 402 e-110 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 394 e-108 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 391 e-107 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 386 e-106 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 383 e-105 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 381 e-104 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 380 e-104 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 380 e-104 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 373 e-102 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 372 e-101 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 366 e-100 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 365 2e-99 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 364 3e-99 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 364 4e-99 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 364 4e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 362 2e-98 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 361 2e-98 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 360 5e-98 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 360 8e-98 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 359 9e-98 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 357 3e-97 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 356 1e-96 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 356 1e-96 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 355 2e-96 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 352 1e-95 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 352 1e-95 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 352 2e-95 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 352 2e-95 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 351 3e-95 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 349 1e-94 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 349 1e-94 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 348 2e-94 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 348 2e-94 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 348 2e-94 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 348 3e-94 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 344 3e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 344 4e-93 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 342 2e-92 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 340 5e-92 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 340 6e-92 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 340 7e-92 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 338 2e-91 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 338 2e-91 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 338 2e-91 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 338 2e-91 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 338 3e-91 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 6e-91 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 337 6e-91 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 336 8e-91 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 336 1e-90 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 334 4e-90 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 333 5e-90 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 333 6e-90 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 333 6e-90 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 333 7e-90 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 332 2e-89 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 332 2e-89 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 332 2e-89 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 330 5e-89 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 330 7e-89 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 330 7e-89 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 330 7e-89 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 328 2e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 328 2e-88 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 328 2e-88 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 328 2e-88 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 328 2e-88 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 328 3e-88 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 327 4e-88 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 327 4e-88 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 326 9e-88 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 326 1e-87 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 325 2e-87 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 324 3e-87 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 323 6e-87 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 323 1e-86 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 321 2e-86 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 320 5e-86 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 318 2e-85 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 318 2e-85 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 318 3e-85 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 317 5e-85 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 316 9e-85 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 316 1e-84 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 315 1e-84 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 315 2e-84 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 314 5e-84 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 313 7e-84 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 312 2e-83 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 312 2e-83 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 311 2e-83 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 311 2e-83 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 311 3e-83 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 311 3e-83 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 310 5e-83 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 310 6e-83 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 309 1e-82 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 309 1e-82 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 306 8e-82 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 305 2e-81 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 305 2e-81 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 305 3e-81 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 305 3e-81 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 303 1e-80 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 303 1e-80 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 301 3e-80 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 300 6e-80 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 300 7e-80 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 299 1e-79 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 299 2e-79 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 299 2e-79 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 296 7e-79 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 295 2e-78 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 291 2e-77 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 291 4e-77 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 288 2e-76 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 286 8e-76 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 284 5e-75 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 283 7e-75 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 281 3e-74 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 280 7e-74 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 280 9e-74 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 279 1e-73 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 276 1e-72 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 272 2e-71 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 268 3e-70 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 268 4e-70 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 267 4e-70 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 266 1e-69 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 263 9e-69 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 259 1e-67 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 258 2e-67 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 258 2e-67 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 257 6e-67 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 256 1e-66 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 252 1e-65 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 252 2e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 248 3e-64 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 245 3e-63 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 244 5e-63 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 243 9e-63 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 240 5e-62 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 240 9e-62 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 234 4e-60 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 228 3e-58 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 225 2e-57 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 224 4e-57 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 221 3e-56 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 219 2e-55 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 218 4e-55 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 216 2e-54 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 214 4e-54 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 211 5e-53 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 211 6e-53 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 205 2e-51 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 204 4e-51 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 199 1e-49 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 199 2e-49 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 192 2e-47 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 191 4e-47 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 190 1e-46 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 187 9e-46 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 184 5e-45 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 177 5e-43 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 173 1e-41 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 172 3e-41 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 169 2e-40 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 169 2e-40 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 167 1e-39 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 157 5e-37 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 157 7e-37 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 152 2e-35 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 146 2e-33 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 145 2e-33 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 143 9e-33 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 136 1e-30 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 135 4e-30 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 120 1e-25 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 119 3e-25 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 114 6e-24 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 114 1e-23 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 113 1e-23 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 102 2e-20 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 100 2e-19 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 89 4e-16 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 89 4e-16 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 88 8e-16 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 87 1e-15 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 86 3e-15 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 82 5e-14 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 82 5e-14 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 78 5e-13 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 78 5e-13 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 77 1e-12 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 75 3e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 75 6e-12 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 75 6e-12 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 75 6e-12 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 72 5e-11 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 67 1e-09 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 65 5e-09 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 64 9e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 64 1e-08 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 63 2e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 61 6e-08 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 59 3e-07 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 59 4e-07 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 58 7e-07 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 55 3e-06 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 55 5e-06 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 6e-05 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 50 1e-04 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 49 5e-04 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 48 6e-04 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 48 7e-04 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 47 0.001 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 47 0.001 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 47 0.001 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 46 0.002 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 44 0.007 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 42 0.034 UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyalop... 42 0.040 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 327/416 (78%), Positives = 370/416 (88%), Gaps = 1/416 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + L+VP+NPIIP+IEGDGIGVD++P M+KVVDAAVEKAYKGE Sbjct: 3 YQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+C RPVR+++G PSPVK P DMVIFRENSEDIYAG+EWKA S +AEKVIKFL Sbjct: 123 QLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLT 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++YA+ NDR SVTLVHKGNIMKFTEGA Sbjct: 183 EEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGA 242 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY++AR+EFG EL+DGGPW++ KNP TGK +V+KDVIADA LQQILLRPAEYDVIA Sbjct: 243 FKDWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIA 302 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAA+VGGIGIAPGAN+ D A+FEATHGTAPKYAGQDKVNPGS+ILSA Sbjct: 303 TLNLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSA 362 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGWTEAADLI+KG GAI AKTVTYDFERLMDGA LL CSEFGDA+I M Sbjct: 363 EMMLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 307/416 (73%), Positives = 360/416 (86%), Gaps = 1/416 (0%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+ Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAAQVGGIGIAPGAN+GDE A+FEATHGTAPKYAG++KVNPGS+ILSA Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 440 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 291/419 (69%), Positives = 346/419 (82%), Gaps = 8/419 (1%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+ Sbjct: 8 LQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query: 65 WMEIYTGEKSTQVYGQD-------VWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA 117 W E++ GEK Q + WL +T++ I Y+V+IKGPLTTP+G G RSLNVA Sbjct: 68 WYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 LRQ++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I Sbjct: 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 FL+ E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+T Sbjct: 187 FLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query: 238 EGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 EGAF WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY Sbjct: 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYS 306 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSII 357 VIA MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSII Sbjct: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LSAEMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM Sbjct: 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 436 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 221/422 (52%), Positives = 291/422 (68%), Gaps = 10/422 (2%) Query: 2 ESKVVVPAQGKKITLQNGK---LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 K+ VP G+KITL+ G + VP+NPIIP I GDGIG DV PA KV++AA E Sbjct: 3 YDKIEVPDAGEKITLKEGSEDEIEVPDNPIIPIIHGDGIGKDVGPAAQKVLEAAAE---A 59 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R ISWM +Y GE + + YG+DV LP ET+D IRE+RVAIKGPLTTPVG G RSLNVAL Sbjct: 60 TGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LDLY +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + +EMG + GIG+KP +E+G+KRLVR AI+YA+ +DRD VTLVHKGNIMKFTE Sbjct: 180 VEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F DWG ++A EE+ + + P W + ++ +++++ +ADA LQ + LR Sbjct: 240 GQFGDWGMEVADEEYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+D++A NLNGDY+SDA AQ+GG+GIAPG N G L E HG+APK AGQD NP Sbjct: 300 EFDILAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGKGRMLAEPVHGSAPKRAGQDMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M ++GW +AADLI +E I++ VTYD ER ++ A+ L SE+ D I++ Sbjct: 360 AMILSGRLMFDYLGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVD 419 Query: 415 NM 416 + Sbjct: 420 TI 421 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 427 bits (1098), Expect = e-118, Method: Composition-based stats. Identities = 261/422 (61%), Positives = 314/422 (74%), Gaps = 17/422 (4%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 +KIT LNVP PIIP+I GDGIG D+ A +V+DAAVEKAY GE++I W E+ Sbjct: 2 TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVL 61 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 G+K+ G+ WLP ETLD I+EY +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLR Sbjct: 62 AGQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLR 119 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PVR+++G PSPVK P+ DMVIFREN+EDIYAGIE+K + + +KVI FL+ EMG IR Sbjct: 120 PVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIR 179 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 FPE GIGIKP S+EGT+RLVRAAI+YAI N+R SVTLVHKGNIMKFTEG+FK WGY LA Sbjct: 180 FPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239 Query: 250 REEFGGELIDGGPWLK-------------VKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 EFG ++ + + + +I+IKD IAD FLQQIL RPAE+ Sbjct: 240 LTEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEH 299 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE--CALFEATHGTAPKYAGQDKVNPG 354 DV+A MNLNGDYISDALAAQVGGIGIAPGANI E A+FEATHGTAPKYAG +KVNP Sbjct: 300 DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPS 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 S+ILS+ +ML H+GW EAAD I +E I +K VTYDF RLMDGA+ + S F D +I+ Sbjct: 360 SVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIK 419 Query: 415 NM 416 N+ Sbjct: 420 NL 421 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 419 bits (1078), Expect = e-116, Method: Composition-based stats. Identities = 206/415 (49%), Positives = 295/415 (71%), Gaps = 3/415 (0%) Query: 2 ESKVVVPAQGKKITL-QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 + VP QG+ I + +NG+ +P PII YI+GDG+G DV P M KVVD+A+ Y+ + Sbjct: 6 YQHINVPEQGQSIKIAKNGQWQIPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAK 65 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI WM++Y GE++ ++Y W P ET++ +RE ++AIKGPLTTP+GGG RSLNVALRQ Sbjct: 66 RKIHWMQVYNGEQAAKLY-DGDWFPQETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQ 124 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 E+DL++ +R ++ + PSP+K+P LT++ + R++SED+Y+GIEW+A S ++EKV+ FL Sbjct: 125 EMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLC 184 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGV ++RF + CGIGIK S+EG++RLVR AI YA+ N+ +S+TLVHKGN++KFT+GA Sbjct: 185 EEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGA 244 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK WG+ LA+ E+ + G WL + ++IK+VIAD LQQ L+ P ++DV+A Sbjct: 245 FKRWGFALAKREYQAIDDENGRWLHIPR-QGQPPLIIKEVIADNMLQQCLMHPEQFDVVA 303 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 N NGD+++D L+AQVGG+GI P AN+ +E A FE THGT + AGQ+K NP S ILSA Sbjct: 304 TTNQNGDFLADMLSAQVGGVGIMPAANLNNEVAFFEPTHGTFARIAGQNKANPSSSILSA 363 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ML+ M W EAA+LI +E + A VT+D + L C++F +IE+ Sbjct: 364 VLMLKFMQWHEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 235/471 (49%), Positives = 304/471 (64%), Gaps = 56/471 (11%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G+KIT QNG+ VP+NPI+P+I GDG G+D+ PA KV+DAAV KAY G+ Sbjct: 1 MYEKITPPSTGEKITFQNGEPIVPDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGK 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISW ++Y G+++ +YG +LP +TL I+EY +AIKGPLTTP+GGGIRSLNVALRQ Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K P+ D++++REN+EDIY GIEWK S E++I L Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 ++ K + P GIGIKP S G++RLVR A+++A+ ++ VTLVHKGNI Sbjct: 181 KDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MK+TEGAF+DWGY+LA +EF E + Sbjct: 241 MKYTEGAFRDWGYELATQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTP 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W + ++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKKAQIVKEVETVINSIWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD CA+FEATHGTAPK+AG DK+NPGS+ILS MML Sbjct: 361 GDYLSDAAAAIVGGLGMGPGANIGDSCAIFEATHGTAPKHAGLDKINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA-KLLKCSEFGDAIIEN 415 +MGW EAADLI +G+ +I VTYD RLM+ + LKCSEF D II+ Sbjct: 421 YMGWQEAADLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 417 bits (1072), Expect = e-115, Method: Composition-based stats. Identities = 196/423 (46%), Positives = 274/423 (64%), Gaps = 13/423 (3%) Query: 2 ESKVVVPAQGKKITLQN-GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K + P G+ + G+L VP+ +I YIEGDGIG +V A +KV + AVEKAY Sbjct: 19 TGKYIDPPSGEYVKYTGPGQLKVPDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKS 78 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 R+I+W EI GEK+ +++G LP ++++++R+ RV +K PL TPVGGG RS+NV LRQ Sbjct: 79 RQITWYEIVVGEKAEKLFGN--RLPDQSIEVLRKIRVFLKAPLETPVGGGFRSINVTLRQ 136 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ED+YAGIEW +S +A K+ +FLR Sbjct: 137 LFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLR 196 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 E GV + GIGIKP S+ GT+R+ R A+++AI N R VT++HKGNI K+TEGA Sbjct: 197 REFGV---NIRDDAGIGIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGA 253 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK+W +++AR EF ++ + ++++ D IAD LQQ+L R EYDVI Sbjct: 254 FKEWAFEVARNEFREHVVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVIL 313 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A VGG+G+APG ++GD + E HGTAPKY G++ VNP + IL+ Sbjct: 314 APNLNGDYVSDEAAGLVGGLGVAPGLDVGDWGMMAEPVHGTAPKYRGKNYVNPTATILAL 373 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERL-------MDGAKLLKCSEFGDAII 413 E+M R +GW E A+ I+KG+E A T D R M ++L EF D ++ Sbjct: 374 ELMFRFLGWREVAEYIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVV 433 Query: 414 ENM 416 E + Sbjct: 434 EII 436 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 196/416 (47%), Positives = 263/416 (63%), Gaps = 8/416 (1%) Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 + P++G+ +NGKL VP+N I+ Y +GDGIG ++ + KV+DAAV+KAY G R+ Sbjct: 9 DEAKPPSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRR 68 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I W E+ GE++ + G LP TL + RV +KGPLTTPVGGG RSLNV LR L Sbjct: 69 IVWWEVTAGEEAQKECG--SLLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVL 126 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY +RPV++Y G P+P HPE D VIFREN+ED+YAGIEW DS +A+K+ FL++E Sbjct: 127 DLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKE 185 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 G I GIGIKP S+ T+R VR A+E+AI N VT++HKGNIMK+TEGAF+ Sbjct: 186 FG---IELTPDTGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFR 242 Query: 243 DWGYQLAREEFGGELIDGGPWLK-VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 W Y L EF ++ +I++ D IAD LQQI+ RP EY+VI Sbjct: 243 QWAYDLILSEFRDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVT 302 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 NLNGDYISD A VGGIG+A G ++GD A+ E HG+APKYAG++ +NP + ILS Sbjct: 303 PNLNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSGM 362 Query: 362 MML-RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +L +GW E L+ ++ AI K VTYD R M G + +E+ D +++ + Sbjct: 363 YLLSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 216/422 (51%), Positives = 289/422 (68%), Gaps = 12/422 (2%) Query: 2 ESKVVVPAQGKKITL---QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 KV VPA+G+KI + N +L++PENPI+P I GDGIG DV PA KV++AA Sbjct: 5 YDKVEVPAEGEKIEVVDEDNDELDIPENPIVPIIHGDGIGKDVGPAAQKVLEAAA---NA 61 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R+ISWM ++ GE + + Y ++ LP +T++ I E+RVAIKGPLTTPVG G RSLNVAL Sbjct: 62 TGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LD Y +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + E+MG + GIGIKP +E G+KRLVR AI+YAI +DRD VTLV KGNIMKFTE Sbjct: 180 VEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F +WG ++A EE+ + + P W + ++ ++++ +ADA LQ + LR Sbjct: 240 GQFTEWGMEVADEEYPDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+ V+A NLNGDY+SDA AQ+GG+GIAPGAN GD L E HG+APK AGQ+ NP Sbjct: 300 EFSVLAMPNLNGDYLSDAAGAQIGGLGIAPGANFGDARVLAEPVHGSAPKRAGQNMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M +MGW +AADL+ +E I++ TVTYD ER ++ A+ L E+ DAI+E Sbjct: 360 AMILSGRLMFDYMGWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVE 419 Query: 415 NM 416 N+ Sbjct: 420 NI 421 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 409 bits (1051), Expect = e-113, Method: Composition-based stats. Identities = 186/420 (44%), Positives = 264/420 (62%), Gaps = 12/420 (2%) Query: 2 ESKVVVPAQGKKITLQNGK-LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 E K +P +G+ I L+ K L VP+NPIIP+IEGDGIG ++T AML +++ AVEK Y G Sbjct: 13 EGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGS 72 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +KI W+E+ G+K+ + G+ LP ETLD+++E V IKGPL TPVG G+RS+N ALR+ Sbjct: 73 KKIYWVELLAGDKAEEKTGE--RLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRR 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 D Y +RPV Y+ G +P+ +PE D+V+FREN++D+YAG+E+ A + +A+KV +FL Sbjct: 131 AFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLI 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 +EMG K+ FPE GI +KP SE TKR VR A+ YA+ N++ +V ++ KGNIMK TEGA Sbjct: 190 KEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGA 249 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F +W +++A E G + ++ + VI D L Q++L+P +DVI Sbjct: 250 FINWAFEVAEE----PEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVII 305 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A+ +GG G P NIGD ALFE+THGTA AG+ NP S+ LS Sbjct: 306 AQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSG 365 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFE----RLMDGAKLLKCSEFGDAIIENM 416 MML ++GW EAA + + + T D + AK + EF + I + + Sbjct: 366 AMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 212/419 (50%), Positives = 284/419 (67%), Gaps = 17/419 (4%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 +K+T+ NG+L VP NP IP+IEGDGIG ++ A V DAAV+KAY G+++++W+ + G Sbjct: 4 EKVTMNNGQLQVPNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAG 63 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131 E + + GQ WLP +TL +REY V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV Sbjct: 64 ETAYKKTGQ--WLPDKTLATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPV 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 YY GTPSPV HPE ++ +FREN+EDIYAGIE D+ DAE+ L ++ + K+RFP Sbjct: 122 TYYPGTPSPVVHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFP 181 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + IKP S++G+ RLV AAI+YA AN+R ++TLVHKGNIMK TEG FK WGY+ A + Sbjct: 182 DTSAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEK 241 Query: 252 E------------FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 + + + +++++ DVI D F QQ LL P ++V+ Sbjct: 242 YGDKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVV 301 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGD--ECALFEATHGTAPKYAGQDKVNPGSII 357 A MNLNGDYISDALAAQVGGIGIAPG NI A+FEATHGTAP++AGQ+K+NP SII Sbjct: 302 ATMNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSII 361 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LS MM ++GW + ++LI G++ AI + VT DF + D A +L S FG+ + + + Sbjct: 362 LSGAMMFDYLGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPD-ATVLSTSGFGEYVAQLI 419 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 233/472 (49%), Positives = 293/472 (62%), Gaps = 57/472 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 +E + K + GIGIKP S+ G++RLVR AI +A + VTLVHKGNI Sbjct: 181 DELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MKFTEG F+DWGY+LA EF E + Sbjct: 241 MKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTE 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W N +++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD A+FEATHGTAPK+AG D++NPGS+ILS MML Sbjct: 361 GDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIEN 415 MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ + Sbjct: 421 FMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 402 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 161/391 (41%), Positives = 221/391 (56%), Gaps = 40/391 (10%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +VT AM V++A + W+ + G + + YG LP Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA-------SGVDLEWIRVEAGVEVIEKYGTP--LPP 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + L+ IRE RVAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + Sbjct: 54 QVLESIRETRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QD 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + +A + + G E IGIKP SE G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGS 167 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+V+ A EYA N R VT VHK NIMKFT+G F ++A+E Sbjct: 168 RRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY-------------- 213 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I +D+I D Q++ +P YDV+ NL GD ISD A +GG+G+APGA Sbjct: 214 ------PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGA 267 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIGD A+FEA HG+APKYAGQ+KVNP ++ILS MMLR++G EAA + ++ I Sbjct: 268 NIGDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAE 327 Query: 387 K-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VTYD + + + E +AI + Sbjct: 328 GKYVTYDLAQ----GEPVGTQEMAEAIAARV 354 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 394 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 118/391 (30%), Positives = 187/391 (47%), Gaps = 60/391 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG +VT A ++V++A K W G ++ + Y + ++P Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIP 52 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + I R+ +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + Sbjct: 53 KELNESIERTRIGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---P 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+V+ REN+E +Y+GIE + E +K +E+ Sbjct: 110 GVDLVVVRENTEGLYSGIEHEVVPGVVE-----------------------SLKIITEKA 146 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R+ + A YA R + +HK NIMK ++G F +++E Sbjct: 147 STRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY------------- 193 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 EI+ + I D Q+++ P +YD++ NL GD +SD A VGG+G+APG Sbjct: 194 -------PEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPG 246 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIG+ ++FEA HG+AP AG++ NP ++I S +MLRH+ +AA+ + + Sbjct: 247 ANIGERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRHLDEQDAANRVKAAVHHVYR 306 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D SEF D ++E + Sbjct: 307 EGKH-----LTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 391 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 67/405 (16%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 TL+N + + + I GDGIG +++ ++ +V A I W + Sbjct: 10 FSTLRNYSSSTSKIQKVTLIPGDGIGPEISESVKRVFSAVKA-------PIEWETVVVDA 62 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 63 N--------TGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCL 114 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G + + V+ REN+E Y+GIE + Sbjct: 115 SIPGHKTRY---NNVNTVVVRENTEGEYSGIENQPVKG---------------------- 149 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F +++ Sbjct: 150 -VAQSIKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY 208 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 I +++ D Q++L P + DV+ NL GD +SD Sbjct: 209 --------------------PSIKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDL 248 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 A +GG+G+ P NIG+ A+FEA HGTAP AG++K NP ++ILS+ MMLRH+G Sbjct: 249 CAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFH 308 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + + V + D CSE+ D +++ + Sbjct: 309 EASIIENAVLNTLTEGKV-----KTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 124/398 (31%), Positives = 189/398 (47%), Gaps = 62/398 (15%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + I GDGIG +++ A+ ++ + I W + + T+ Sbjct: 1970 KSSSTTIKTVALIPGDGIGPEISAAVQEIFK-------FADVPIKWESVDVTPRPTE--D 2020 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P +LD+IR++ + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G + Sbjct: 2021 GRFRMPQSSLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYET 2080 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 P K D+V REN+E Y+GIE + IK Sbjct: 2081 PYK---NVDLVTVRENTEGEYSGIEHVIVDGVVQ-----------------------SIK 2114 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +EE ++R+ R A +YA N R SVT VHK NIM+ ++G F + A Sbjct: 2115 LITEEASRRVARFAFQYAKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAH-------- 2166 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +EI D+ D ++ P +DV+ NL GD +SD A +GG Sbjct: 2167 ------------HREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNLYGDILSDLAAGLIGG 2214 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 +G+ P NIG+ A+FE+ HGTAP AGQD+ NP +++ SA MMLR+M + ADLI Sbjct: 2215 LGVTPSGNIGETGAIFESVHGTAPDIAGQDRANPTALLFSAIMMLRYMNLNKHADLIESA 2274 Query: 380 MEGAINA-KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I K +T D CS++ I + Sbjct: 2275 VLATIREAKYLTADL------GGRSTCSQYTKEICRQI 2306 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 122/395 (30%), Positives = 180/395 (45%), Gaps = 55/395 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + GDGIG ++ A++ V+ A + I GEK Y Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA-------VPLRLETIEIGEKLYNKY-YTY 52 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV 141 + +T I + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + Sbjct: 53 GITEDTWSQIFRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNT-- 110 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 D+VI REN ED+YAGIE+ +K Sbjct: 111 -SAPEIDVVIIRENEEDLYAGIEYH-----------------------HTADTYESVKLI 146 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S G+++++R A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 147 SRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYS-------- 198 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + D +++ P ++DVI NL GD +SD A G IG Sbjct: 199 ------------NIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIG 246 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +A ANIG + A+FEA HG+AP AGQ+ NP ++ +A MML H+G TE A I ++ Sbjct: 247 LAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALK 306 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T D + + EF AII N+ Sbjct: 307 KTIEDGIHTADIYNPSISSTKVGTKEFAQAIINNL 341 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 119/390 (30%), Positives = 180/390 (46%), Gaps = 61/390 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA I W E + Q G +P+E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA-------PIQWEERNV--TAIQGPGGKWMIPSE 83 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + + ++ +KGPL TP+ G S+N+ LR+ DLY +RP +G +P Sbjct: 84 AKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DV 140 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++V REN+E Y+GIE + IK +E +K Sbjct: 141 NIVTIRENTEGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASK 177 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A EYA N R +VT VHK NIM+ ++G F ++A Sbjct: 178 RIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE----------------- 220 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + K+I ++ D ++ P+++DV+ NL GD +SD A +GG+G+ P N Sbjct: 221 ---SCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGN 277 Query: 328 IGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG A+FE+ HGTAP AG+D NP +++LSA MMLRHMG + A I I Sbjct: 278 IGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKD 337 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D KCS+F + I + Sbjct: 338 GK-----SLTKDLGGNAKCSDFTEEICRRV 362 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 109/389 (28%), Positives = 169/389 (43%), Gaps = 66/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V A + +++ + + G+++ + YG+ LP E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL-------DLPFEYSYYDAGDEALEKYGK--ALPDE 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 TL+ R+ + G + V LR+EL + +RP + +G Sbjct: 54 TLEACRKSDAVLFGAAG----ETAADVIVRLRRELGTFANVRPAKAIEGIECLY---PGL 106 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E +Y G E+ I+ + E ++ Sbjct: 107 DIVVVRENTECLYMGFEFGFG------------------------DVTEAIRVITREASE 142 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A E A R VT +HK N+MK T G F+D ++A++ Sbjct: 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY--------------- 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 EI D DA +++ P +DVI N+ GD +SD A VGG+G+AP AN Sbjct: 188 -----PEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G+ A+FE HG A AG+ NP ++IL+A MMLRH G+ E A + + +E I Sbjct: 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D LK EF + + + Sbjct: 303 KKTPDL------GGNLKTMEFANEVASLL 325 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 107/408 (26%), Positives = 174/408 (42%), Gaps = 60/408 (14%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A + T K + +N + G GIG +++ A+ + AA + I W Sbjct: 287 AMIPRYTFSQKKKSQKQNHKVVLFPGHGIGPEISQAVCDIFAAA-------KVPIDWEHH 339 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 K G + E+L+ + Y+ +KGP TP+G G RSLNV +R++L+L+ + Sbjct: 340 EIYTKPINEAGD--LIKEESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANV 397 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RP R G +P D+V REN+E Y+G+E E Sbjct: 398 RPCRSLAGVKTPYS---NVDLVTIRENTEGEYSGLEHAVVPGVVE--------------- 439 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S+ + + R A E+A N+R V HK +MK +G F + ++ Sbjct: 440 --------NLKIISQPACENIARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKI 491 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + E EI + D ++ P +DV+ NL GD Sbjct: 492 SSEY--------------------PEIEYTEEQIDTVCMKLSKNPEVFDVMVMPNLYGDI 531 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A +GG+G+ NI CA++EA HGTAP AG +K NP +++LS MML+ MG Sbjct: 532 VSDLCAGLIGGLGLTASGNISHTCAVYEAVHGTAPDIAGLNKANPTALLLSGVMMLKAMG 591 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I + + ++ D +++ A+I ++ Sbjct: 592 LQKEGFAIEEAVIKTLSEGK-----FLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 373 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 131/417 (31%), Positives = 197/417 (47%), Gaps = 62/417 (14%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 ME A K + NGK + I GDGIG ++ + ++++A Sbjct: 1 MEQSGGSGATMKYVVTPNGKKL------VTLIPGDGIGPEIVESACRLIEAV-------G 47 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 I W G + G +P +T++ I+ RV +KGPL TPVG G +S NV LR+ Sbjct: 48 APIEWEVRRAGASVFRE-GIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRK 106 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 + + +RPVR P+P + D+V+ REN ED+YA IE++ Sbjct: 107 LFEAFANVRPVRELPSVPTPYRG-RNIDLVVVRENIEDLYAAIEYRETPGVT-------- 157 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 I K S +G+++++R A E A A R VT K NI+K TEG Sbjct: 158 ---------------IAHKLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGW 202 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F+ ++A E +I +I D Q++ P +++VI Sbjct: 203 FQHIFEEIASEY--------------------PDIEANHLIIDNCAHQLVKAPEQFEVIV 242 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGD ISD + VGG+G A N G E A+FE HGTAPKYAG++ +NP ++IL+A Sbjct: 243 TTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTA 302 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 MMLR++ E A+ I + + + +T D + + + + F DAII N+ Sbjct: 303 VMMLRYIDEFETAETIEQALIVTLEEGKALTRDV---VGDERAVSTTAFTDAIIANL 356 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 372 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 115/400 (28%), Positives = 188/400 (47%), Gaps = 63/400 (15%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 G+ + IEGDGIG +++ ++ + AA I W + + + Sbjct: 47 GQKGADGKYTVTLIEGDGIGPEISQSVKDIFSAA-------NAPIKWEPVDV---TPILK 96 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 +P + ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G Sbjct: 97 DGKTAIPDDAIESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYK 156 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +P + D V+ REN+E Y+GIE + I Sbjct: 157 TPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQ-----------------------SI 190 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K ++E ++R++R A +YA + ++ V +VHK IMK ++G F + ++A++ Sbjct: 191 KLITKEASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDF------ 244 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQ 316 ++ + D +I+ P Y+ V+ NL GD +SD A Sbjct: 245 --------------PDVEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGL 290 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GG+G+ P NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A I Sbjct: 291 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAGRI 350 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D K SE+ +AI++ + Sbjct: 351 QKAIFDTLAEGK-----ALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 139/405 (34%), Positives = 203/405 (50%), Gaps = 58/405 (14%) Query: 15 TLQNGKLNVPE--NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 T K++V E +I I GDGIG + A LKV++AA +++ G Sbjct: 6 TETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKA-------PLAYEVREAGA 58 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + G +P ET++ IR+ RV +KGPL TPVG G +S NV LR+ + Y +RPVR Sbjct: 59 SVFRR-GIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVR 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + P+P D+V+ REN ED+YAGIE + Sbjct: 118 EFPNVPTPYAG-RGIDLVVVRENVEDLYAGIEHMQTPS---------------------- 154 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +K S +G++++VR A E A A R V K NIMK EG K Q+A+E Sbjct: 155 -VAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEY 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +I +I D Q++ RP +++VI N+NGD +SD Sbjct: 214 --------------------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDL 253 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + +GG+G AP ANIG+E A+FEA HG+APKYAG++ +NP +++LSA MMLR++ Sbjct: 254 TSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFAT 313 Query: 373 ADLIVKGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI + + +T D G K +E+ +AII+N+ Sbjct: 314 ADLIENALLYTLEEGRVLTGDVVGYDRG---AKTTEYTEAIIQNL 355 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 115/392 (29%), Positives = 174/392 (44%), Gaps = 53/392 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG ++ A LKV+ + ++ +I G K + G + Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVI-------LEAGAELEIEKIEIGFKVYSM-GNPSGI 53 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + ++ +V +K P+TTP GGG +SLNV +R+ L LY +RP Y P Sbjct: 54 EPSSWESLKRTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY--APFIHTKH 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN ED+Y GIE + +K + + Sbjct: 112 PGIDLVIIRENEEDLYGGIEHRQG-----------------------VDSFQALKIMTRQ 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 GT+R++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 149 GTERIIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEY------------ 196 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I + I D ++ P +DV+ NL GD +SD G +G+ Sbjct: 197 --------PQIEKEHWIIDIGSAKLADNPQSFDVLVLANLYGDILSDVAVQIAGSVGLGA 248 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG E ++FEA HG+AP+ AGQ+ NP ++L+A ML H+G AD + I Sbjct: 249 SANIGHEYSMFEAIHGSAPRRAGQNVANPSGLLLAAVQMLIHIGQNAVADRVYNAWLKTI 308 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 TYD R + EF +I+N+ Sbjct: 309 EEGIHTYDIFREGVSKVKVGTREFARHVIKNL 340 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 121/389 (31%), Positives = 182/389 (46%), Gaps = 55/389 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG ++ A+L ++ A + I I GEK + + ++ Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEAR-------IRLETIEVGEKLYVKH-YSSGISEQS 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELT 147 + I V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + Sbjct: 59 WESIERTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL---HPNL 115 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++ I REN ED+YAGIE+ R + +K S G + Sbjct: 116 NLTIIRENEEDLYAGIEY-----------------------RQTHNMYESVKLISRTGCE 152 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 +++R A EYA+ N+R VT + K NIMKF++G F ++A+E Sbjct: 153 KIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEY--------------- 197 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I + I D ++ +P +DVI NL GD ISD A G +G+A AN Sbjct: 198 -----PQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSAN 252 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG+ A+FEA HG+AP AGQD NP ++ +A MML H+G + A LI + I Sbjct: 253 IGEHYAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDG 312 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D K + EF + +++ + Sbjct: 313 MHTADIYNKDHSTKKVGTKEFAEEVVKRL 341 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 364 bits (934), Expect = 4e-99, Method: Composition-based stats. Identities = 112/399 (28%), Positives = 186/399 (46%), Gaps = 71/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG +V P +K+++ E ++ G + + YG LP + Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPED 52 Query: 88 TLDLIREYRVAIKGPLTTPVGG---GIRSLNVALRQELDLYICLRPVRYY-------QGT 137 T++ +E + + G +T+P G +S + LR+ LY +RP+ + + Sbjct: 53 TIEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIA 112 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D+VI REN+ED+Y G E R I Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRE------------------------RLENDTAIA 148 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G++R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 149 ERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY----- 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I D + D+ ++ P ++DVI N+ GD +SD +A + Sbjct: 204 ----------------NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP ANIGD+ ALFE HG+AP AG+ NP + ILS M+ ++G E DLI Sbjct: 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ + K VT D LK + GD I+ + Sbjct: 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEILNYI 340 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 364 bits (934), Expect = 4e-99, Method: Composition-based stats. Identities = 98/425 (23%), Positives = 169/425 (39%), Gaps = 59/425 (13%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 121 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 177 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 178 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 235 Query: 118 LRQELDLYICLRPVRYYQ----GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAE 173 LR L ++ LRP + + E D+++ RE + IY G Sbjct: 236 LRSGLKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFG----------- 284 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNI 233 + G K E G + + R+ R A E A R + V K N+ Sbjct: 285 -------KPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFETAQKR-RGKLCSVDKANV 336 Query: 234 MKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 ++ + ++ +A E ++ + + D Q++ P Sbjct: 337 LEASM-LWRKRVTAMASEY--------------------PDVELSHMYVDNAAMQLVRNP 375 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVN 352 ++D I N+ GD +SD + G IG+ P A++G+ LFE HG+AP AGQDK N Sbjct: 376 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKAN 435 Query: 353 PGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDA 411 P + +LSA M+LR+ +G AA I + ++ T D G KL+ C E G+ Sbjct: 436 PLATVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEA--GTKLVGCKEMGEQ 493 Query: 412 IIENM 416 +++ + Sbjct: 494 VLKAV 498 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 362 bits (929), Expect = 2e-98, Method: Composition-based stats. Identities = 121/388 (31%), Positives = 174/388 (44%), Gaps = 55/388 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + GDGIG ++T A++ ++ AA + + GE+ G +P E Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA-------GAHLDAEYVEVGEQVYLR-GNTSGIPQEA 75 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 D I RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P D Sbjct: 76 WDSIARTRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHPDMD 133 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN ED+YAGIE R + +K + G++R Sbjct: 134 VVIVRENEEDLYAGIEH-----------------------RQTQDVAQCLKLITRSGSER 170 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + R A EYA + R +T + K NIMK T+G F ++ARE Sbjct: 171 IARYAFEYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY---------------- 214 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 EI I D + + RP +YDV+ NL GD +SD A G +G+ NI Sbjct: 215 ----PEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQMTGSVGLGGSVNI 270 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G A+FEA HG+AP A +D NP ++L+A MLRH+ A ++ + Sbjct: 271 GSGGAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHLKLDSIAAKVMNAWLCTLEEGI 329 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + F +A+IE + Sbjct: 330 HTVDIAG-AHTKERAGTRRFTEAVIERL 356 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 110/392 (28%), Positives = 174/392 (44%), Gaps = 66/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIGV+V A L +++ + + ++ G+ + G L Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TAL 52 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ETL+ + E R + G + V LR+E DL+ LRPV+ G P Sbjct: 53 PEETLEAVGEARATLFGAAG----ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY--- 105 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D VI REN+ED+Y G E + + + + Sbjct: 106 PDLDFVIVRENTEDLYVGDE------------------------EYTPEGAVAKRIITRT 141 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ + A +YA VT VHK N++K T+G F+D Y++A E Sbjct: 142 ASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY------------ 189 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ D DA ++ +P E+ I NL GD +SD A +GG+G+AP Sbjct: 190 --------PQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAP 241 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG++ ALFE HG+AP+ AG++ NP ++IL+ +ML+H+ + A I K ++ + Sbjct: 242 SANIGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTL 301 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT D L E I ++ Sbjct: 302 AEGLVTPDL------GGKLGTMEMAAEIARHL 327 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 360 bits (924), Expect = 5e-98, Method: Composition-based stats. Identities = 114/392 (29%), Positives = 176/392 (44%), Gaps = 65/392 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I IEGDGIG +V PA +V++A + ++E G ++ + G V P Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PE 53 Query: 87 ETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 ET++ I + G T+P G LR+ LDLY +RP + P P Sbjct: 54 ETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRP---VPGSRP 110 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN+E +Y E + I S++ Sbjct: 111 -GVDLVIVRENTEGLYVEQERR------------------------YLDVAIADAVISKK 145 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 146 ASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDF------------ 193 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++D+I D Q+++RP +DVI NL GD +SD A VGG+G+AP Sbjct: 194 --------PLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAP 245 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIGD A+FE HG+AP AG+ NP + ILSA MML ++G EAA + K ++ + Sbjct: 246 SGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVL 305 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D F +A++E + Sbjct: 306 ERGPRTPDL------GGDATTEAFTEAVVEAL 331 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 360 bits (923), Expect = 8e-98, Method: Composition-based stats. Identities = 118/410 (28%), Positives = 184/410 (44%), Gaps = 63/410 (15%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 Q + +IEGDGIG +++ ++ K+ AA I W Sbjct: 20 QPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESCD 72 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 S +P + I + VA+KGPL TP+G G RSLN+ LR+ L+ +R Sbjct: 73 V---SPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVR 129 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 P + +G + E D+V+ REN+E Y+GIE + Sbjct: 130 PAKSIEGFKTTY---ENVDLVLIRENTEGEYSGIEHIVCPGVVQ---------------- 170 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 IK + + ++R++R A EYA A R V +VHK I + +G F + +L+ Sbjct: 171 -------SIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELS 223 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY--DVIACMNLNGD 307 +E ++ ++ + D + +++ P+ Y V C NL GD Sbjct: 224 KEY--------------------PDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGD 263 Query: 308 YISDALAAQ-VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 +SD + G +G+ P ANIG + ++FEA HG+AP AGQDK NP +++LS+ MML H Sbjct: 264 ILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNH 323 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MG T AD I + I + R D A S F +A+I+ + Sbjct: 324 MGLTNHADQIQNAVLSTIASG----PENRTGDLAGTATTSSFTEAVIKRL 369 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 359 bits (922), Expect = 9e-98, Method: Composition-based stats. Identities = 100/404 (24%), Positives = 156/404 (38%), Gaps = 56/404 (13%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG +V P ++V++AA K K+++ + Q Sbjct: 1 MITNQQYKIAVIPGDGIGNEVVPEGIRVLEAASAK---FGFKLAFTTYDWSCARY--HSQ 55 Query: 81 DVWLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 +P++ ++ +R+ G + P + +L + +R+E D Y+ LRPVR G Sbjct: 56 GSMMPSDGIERLRDSDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGV 115 Query: 138 PSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ K P D I REN+E Y+ + G Sbjct: 116 PCPLANKKPGDIDFWIVRENTEGEYS-------------------QVGGRMFAGTEHEFV 156 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + GT R++R A + A R+ VT K N + + + + + E Sbjct: 157 TQEAIFTRRGTDRIMRYAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEY--- 213 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I D + + P +DV+ NL GD +SD Sbjct: 214 -----------------PDIRTDQYHIDILAARFAMSPERFDVVVGSNLFGDILSDLGPG 256 Query: 316 QVGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 G I +AP ANI E ++FE HG+AP AGQ NP I S MML H+G EA Sbjct: 257 ITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIWSGAMMLEHLGQPEA 316 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I++ +E + D D + G I + Sbjct: 317 AAAIMQAIETVLTH----PDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 103/389 (26%), Positives = 174/389 (44%), Gaps = 64/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG ++ PA +KV+DA + + + G + G + Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNN 52 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L+ I+ + G +TT +S+ + +R+ELDLY +RPV+ G + V Sbjct: 53 DLETIKGCDAVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGI-TGVTGRNDF 111 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D +I REN+E +Y+GIE + + +G++ Sbjct: 112 DFIIVRENTEGLYSGIE------------------------EIGPELSWTKRVVTRKGSE 147 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A + A ++ +T+VHK N++K ++ F D Q A Sbjct: 148 RIAEYACKLAKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTA------------------ 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + + +D++ D+ +++RP YD++ NL GD +SD AA VG +G+ P AN Sbjct: 188 ---SANGVEYEDMLVDSMAYNLIMRPERYDIVVTTNLFGDILSDMCAALVGSLGLVPSAN 244 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG++ A FE HG+AP AG+ NP + IL +M+L MG + +I + + + K Sbjct: 245 IGEKYAFFEPVHGSAPDIAGKGIANPLAAILCVKMLLEWMGEPR-SQIIDEAIAYVLQKK 303 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D E G+A+ E + Sbjct: 304 IITPDL------GGTASTMEVGNAVAEYV 326 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 133/394 (33%), Positives = 191/394 (48%), Gaps = 60/394 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I+GDG+G DV A L V+DA +K I ++ G + + YG + L Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKK---FNLDIEYVPAVAGLNTVEKYGTN--L 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 P ETLD ++E +KGP TTP G + S NV +R+ DLY +RP + PS Sbjct: 59 PKETLDTLKETDCVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--- 115 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 DMVI REN+E +Y+G++++ + + IGI+ + Sbjct: 116 KPNVDMVIVRENTEGMYSGLDFRVN-----------------------QETTIGIRVITR 152 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + +R+V+ A + A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 153 KACERIVKYAFKLAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKK------------ 199 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ D DA Q + +P YDVI NL GD ISD A VGGIG Sbjct: 200 --------HPDVKADDAHVDAITQWFIKQPEFYDVIVTENLFGDIISDEAAMVVGGIGTG 251 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 ANIGD+ A+FE HG+ PKY G DKVNP I+S +MML M + EA I + Sbjct: 252 ASANIGDKYAMFEPIHGSVPKYTGMDKVNPIGTIMSVKMMLDWMDYKEAGKAIEDAVYKV 311 Query: 384 INAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +TYD KCSE G I + Sbjct: 312 LEEGKILTYDL------GGTAKCSEVGKEIASKV 339 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 56/398 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG++V A ++VV+ + G I + I G + +G+ ++ Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVS 101 Query: 86 AETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + LD +R++ + G + P + L +ALR L LY +RPVR + GT P+ Sbjct: 102 EDCLDTLRKFDAGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLN 161 Query: 143 HP-ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 E D ++ RENSE Y+G + G + P + Sbjct: 162 TATEGIDWMLVRENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMF 202 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + G +R++R A E A + R +T+V K N M+ + ++A++ Sbjct: 203 TRVGIERIMRFAFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDF--------- 253 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++ ++ DA +++ +P D I NL+ D +SD AA G IG Sbjct: 254 -----------PDVTWDKMLVDAMTVRMVAKPQSIDTIVGTNLHMDILSDLAAALAGSIG 302 Query: 322 IAPGANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 +AP +N+ ++FE HG+A G+ NP + SA ML +G EAA ++ Sbjct: 303 VAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLSWLGEKEAAKQLMD 362 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E A +T D DA+ + + Sbjct: 363 CVEKVCAAGILTPDL------GGTSNTQGVVDAVKKEI 394 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 355 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 114/390 (29%), Positives = 181/390 (46%), Gaps = 56/390 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + GDG+G ++ ++L+++ ++ +I I G+K + G + Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEII-------FEAGAEIQIDTIEIGQKIYEK-GWPSGISD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P Sbjct: 54 SGWETLKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----K 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN ED+Y+GIE+ R K +E + Sbjct: 109 MDIVIIRENEEDLYSGIEY-----------------------RQTLDTYNCTKVITESTS 145 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 146 ERICRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEY-------------- 191 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I ++ I D +I P ++DVI +NL GD ISD A G +G+ Sbjct: 192 ------PDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGLGGSI 245 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+E A+FEA HG+AP A QD NP ++ +A ML ++G E A + + + Sbjct: 246 NIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKS 305 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + + +F + II N+ Sbjct: 306 GVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 99/406 (24%), Positives = 172/406 (42%), Gaps = 63/406 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG +V +KV++ EK K+++ E + G + G L Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEK---FGFKLNFNEFFVGGAAIDHCGYP--L 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGT 137 PAETL E + G + P + R + LR+ L+ LRP Y+G Sbjct: 57 PAETLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGL 116 Query: 138 P--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 P++ + DMV+ RE + IY G + + + Sbjct: 117 EKFCPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGS-------------------Q 157 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ RAA E A+ + VT V K N+++ + +++ ++A++ Sbjct: 158 TKAFDTEVYYKYEIERIARAAFEAAMKRN-KKVTSVDKANVLQ-SSILWRETVTEMAKDY 215 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 E+ ++ + D Q++ P +DV+ C N+ GD ISD Sbjct: 216 --------------------PEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDE 255 Query: 313 LAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 A G +G+ P A++ + L+E G+AP AG+ NP + ILSA MMLR+ Sbjct: 256 AAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLN 315 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EAAD I ++ + + T D D + + +E G I + + Sbjct: 316 EAADAIESAVQKVLASGHRTADLA---DDSTPVSTAEMGTLITQAI 358 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 104/396 (26%), Positives = 164/396 (41%), Gaps = 63/396 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + I IEGDGIG +V PA V++A K ++E G ++ + G V Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV 53 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P TL+ + + G T+P G +R++LDL+ +RP +++ P Sbjct: 54 --PEATLEAVTHTDATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHHP---VP 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+++ REN+E +Y E I Sbjct: 109 GSRP-GVDLIVVRENTEGLYVEQERSYLEG----------------------EIAIADTV 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + + R+ A A + R + + HK N++ T+G F + A Sbjct: 146 ITRKASARIGEYAARLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARF-------- 197 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 E+ +D+I D Q++ P +DVI NL GD ISD A VGG+ Sbjct: 198 ------------PEVKTQDIIIDNCAMQLVRNPERFDVIVTTNLFGDIISDLTAGLVGGL 245 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 GIA NIG + A+FE HG+AP AG+ NP + ILS MML H+G EAA + + Sbjct: 246 GIAASGNIGIKHAVFEPVHGSAPDIAGKGIANPAATILSGVMMLDHLGEHEAARRVEAAV 305 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D +F +A+ ++ Sbjct: 306 DKVLQEGPRTPDL------GGNATTLQFAEAVARSL 335 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 352 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 57/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I DGIG +V A L+V++A ++ G+ I G + G V + Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKR--SGDFSIHTETFDWGSDYYKKNG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ ++++ G + P + L + + Q D Y +RP + G P+ Sbjct: 58 PADGLEQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 ++ P D VI RENSE Y+G +A PE G + Sbjct: 118 RNCGPGDLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVA 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G R++R A + A A R +T+V K N + + + ++++E Sbjct: 159 IFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ ++ DA ++ L+P D I NL+ D +SD A G Sbjct: 212 -------------PDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHADILSDLAGALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+AP ANI E ++FE HG+A G+ NP + +A ML H+G +AA + Sbjct: 259 LGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFWTAAQMLEHLGEKDAATRL 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E A +T D + DA+ E + Sbjct: 319 MSAVERVTEAGILTPDV------GGTADTQQVTDAVCEAI 352 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 352 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 99/399 (24%), Positives = 160/399 (40%), Gaps = 55/399 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGIG +V LKV+ +K Y + + +G+ + Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADM--FLWNSEYYLQHGR--MM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P LD+++ Y + G + P + L + +R+ Y+ LRPV+ +G P Sbjct: 58 PENGLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 142 KHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 H E + VI REN+E Y+ G + + Sbjct: 118 IHQERPINFVIVRENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTI 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +GT+R+ R A +YA + V K N + + + + +A E Sbjct: 159 ITRKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEY-------- 210 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I ++ DA + RP VI NL GD +SD +A VGG+ Sbjct: 211 ------------PDIQLEKYYIDALAAYFVQRPDTLQVIVASNLFGDILSDLGSALVGGL 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GI+P ANI E ++FE HG+AP AG+ K NP + I SA +ML+ +G + A +I+ Sbjct: 259 GISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E D +E G+ I+ + Sbjct: 319 KAIEKVTEHGEK-----LTEDLGGNSTTAEMGEEIVRQI 352 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 107/401 (26%), Positives = 166/401 (41%), Gaps = 69/401 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GDGIG +++ + L +++A + + ++ G+ + G+ Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAIND---NFPLSLEIKKLEAGDAVLKNTGK-- 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 LP ET + I+ +K P+ + + V LR+ LDLY +RP + Y PS Sbjct: 56 ALPDETFEAIKNSDACLKAPVG----ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D+VI REN+ED+Y G E+ + + S Sbjct: 110 -RDDVDLVIVRENTEDLYTGEEFDIG------------------------DAAVAFRIIS 144 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ +KR+ A A VT VHK N+MK T+G F ++A + Sbjct: 145 EKASKRIANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDF---------- 194 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ +++ DA ++ +P +DVI NL GD +SD A VGG+G+ Sbjct: 195 ----------PDVKFEEMYVDACAMNLIRQPQLFDVIVTTNLFGDILSDESAQVVGGLGM 244 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EAADL 375 AP ANIGD LFE HG A AG+ NP S ILS +MML +G E Sbjct: 245 APAANIGDNFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLDWLGNKHNDQKCIEVGQK 304 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D EF II + Sbjct: 305 LEDVVYDIVKNNIKTKDI------GGDKTTMEFTKEIISRL 339 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 113/393 (28%), Positives = 176/393 (44%), Gaps = 69/393 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG VT A+ +V++A + + +V G +P E Sbjct: 40 TVTLIPGDGIGPLVTGAVEQVMEAMHAPVHF--------------ERYEVLGNMRKVPEE 85 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 ++ ++ +V +KG L TPVGGG+ SLN+ LR+ELD++ L G V E Sbjct: 86 VIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGL---VTRHENV 142 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E Y+G+E + E +K ++ ++ Sbjct: 143 DIVVIRENTEGEYSGLEHEVVPGVVE-----------------------SLKVITKFCSE 179 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A EYA N+R VT VHK NIMK +G F + ++A+ G Sbjct: 180 RIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG------------- 226 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I ++I D Q++ +P ++DV+ NL G+ I++ A GG G+ PG N Sbjct: 227 -------ITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGN 279 Query: 328 IGDECALFEATHGTA----PKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 +G E A+FE K Q K NP +++LS+ MMLRH+ + AD + ++ Sbjct: 280 VGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQV 339 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I R D E DA+I + Sbjct: 340 IKEGK-----YRTKDLGGDCTTQEVVDAVIAAL 367 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 109/407 (26%), Positives = 170/407 (41%), Gaps = 56/407 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + + + + I I GDG G + LKV+ AA K + + G + Sbjct: 7 KEDRTTMQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGK---EGFALETTVLDWGGEYYL 63 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRY 133 G+ LP + ++ ++ Y G + P G + + + LR ELD YI LRPV+ Sbjct: 64 RTGE--VLPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKL 121 Query: 134 YQGTPSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 Y G +P+ K PE D V+ REN+E +YAG G K P Sbjct: 122 YPGVETPIAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTP 162 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + I + +G +R VR A EY R VTL K N++ F ++ ++ Sbjct: 163 DEVAIQTSINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGE 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 E +I DA ++ P +DVI N+ GD I+ Sbjct: 223 EY--------------------PDIERDYAHVDAICMWMVKNPEWFDVIVTDNMFGDIIT 262 Query: 311 DALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 D A GG+GIA G N+ E ++FE G+APKY G++ +NP + + + MML +G Sbjct: 263 DLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVINPLAAVCAGAMMLEQLGE 322 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA I + ++ + L G E GD ++ ++ Sbjct: 323 TGAAARIEEAVKKVCAGH-----LKSLAAGRMGYGTDEVGDLVVSHL 364 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 98/401 (24%), Positives = 159/401 (39%), Gaps = 58/401 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDGIG +V PA + + E G + + G + +G V + Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ +R+ + G P + L + + Q LD Y +RP R G P+ Sbjct: 58 PADGLEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 K E D VI RENSE Y+G+ + P + Sbjct: 118 KRCTAEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAATDVS 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R++R A A + R +T+V K N + + + +++RE Sbjct: 159 MMTRAGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + DA +++ RPA D I NL+ D +SD AA G Sbjct: 212 -------------PDVRWDKELVDAATARMVNRPASLDTIVATNLHADILSDLAAALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GIAP NI E ++FE HG+A G+ NP S M+L H+G +AA + Sbjct: 259 LGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGTFWSVVMLLEHLGEHQAAARM 318 Query: 377 VKGMEGAINAKTVTYDFE-RLMDGAKLLKCSEFGDAIIENM 416 ++ +E T D D + A+ +++ Sbjct: 319 MRAVESV------TADQALHTRDLGGTATTEQVTQAVCQHL 353 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 130/394 (32%), Positives = 187/394 (47%), Gaps = 31/394 (7%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G ++ A V+D A KI W G+++ + L Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAA---RLSGFKIDWDVHQAGQRALAE--SESLL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQ-GTPSPVKH 143 P TL+ IR A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR + Sbjct: 57 PDATLNSIRTNGAALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLPIASTQEEPE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+V+ REN+ED+YAG+E+ S A V++ L G P + +KP + Sbjct: 117 RPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTP 172 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R+V A +A + R V V TEG F ++A Sbjct: 173 HGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAAR------------ 220 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 I + V A ++ P +DV+ NL GD ISD AA VG +G+A Sbjct: 221 --------HPSIASRTVPVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVA 272 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 PGANIG A+FEATHG+AP++AG ++NP ++I S M+L H+G E A I +E Sbjct: 273 PGANIGAHHAVFEATHGSAPEFAGSGRLNPTALIFSGCMLLDHLGEHETAARIRAAVEDV 332 Query: 384 INAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A +T+D A EF A+ + + Sbjct: 333 VAAGEVLTFDLLAPQRSADAATTVEFTRAVTDRL 366 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 127/397 (31%), Positives = 183/397 (46%), Gaps = 59/397 (14%) Query: 23 VPENPII--PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG ++ +++ V+DA W Y G + G Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGD 59 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP ET+ I ++A+KGPLTTP GGG RS+NV LR+E +L+ +RP P Sbjct: 60 P--LPRETIQSIHHNKLALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IP 113 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D+ + REN + YA E D P + Sbjct: 114 GGRFENVDITLIRENLDGFYAAFEHYMPIGD------------------DPHAVAMCAGF 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G R++R A EYA+ N R VTLVHK NI+K G F + G ++A+E Sbjct: 156 NTRTGCHRIIRYAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I ++ I DA Q++L P +DVI NL GD +SD +A +GG+ Sbjct: 208 -----------EGRIAFEERIVDACAMQLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGL 256 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+APG NIG + A+FEA HG+AP AG+ NP +++L+A MML H+G T+ A + + Sbjct: 257 GLAPGGNIGKQAAIFEAVHGSAPDIAGKGIANPLALMLAAAMMLDHVGKTDLATRLRNAI 316 Query: 381 E-GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D K E A+I + Sbjct: 317 RITTLEDGIRTPDL------GGTAKTRELTQALISRI 347 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 105/402 (26%), Positives = 168/402 (41%), Gaps = 66/402 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V LKV++ +K + + + G + +G+ LP E Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKK---TGKTFEKVFGHIGGDAIDRFGEP--LPEE 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLYICLRPVRYYQGTP-- 138 T + E G + P + +ALR+ L+LY +RP++ Y+ Sbjct: 57 TKKICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHV 116 Query: 139 SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K D+V RE S +Y G E G Sbjct: 117 SPLKEKVIGSGVDLVTVRELSYGVYYGQP-----------------------RGLDEEKG 153 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + +R+ R A E A N R VT V K N++ ++ ++ ++ARE Sbjct: 154 FDTMIYDRKTVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREY--- 208 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + D Q++L+P+++DVI N+ GD +SD AA Sbjct: 209 -----------------PDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAA 251 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A+ GD+ L+E G+AP AG++ NP + ILS MML H G E A Sbjct: 252 LPGSLGLLPSASFGDKN-LYEPAGGSAPDIAGKNIANPIAQILSLAMMLEHSFGMVEEAR 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +E I T D + K + S+ GD I + + Sbjct: 311 KIERAVELVIEEGYRTRDIAEDPE--KAVSTSQMGDLICKKL 350 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 93/402 (23%), Positives = 154/402 (38%), Gaps = 60/402 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V KV++ K + +I+ + G + +G LP T Sbjct: 4 IAILAGDGIGPEVMVEAKKVLNTVASK---FDFEITTQDYDIGGAAIDNHGN--ALPDST 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + E + G + P + R + LR DL+ +RP S Sbjct: 59 MAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLS 118 Query: 142 K-----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + D+++ RE + DIY G E G Sbjct: 119 TLRSDISEQGFDVLVIRELTGDIYFGEPKGRRGEG-------------------EEETGF 159 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 S KR+ A + A + + VT V K N++ T ++ ++A E Sbjct: 160 DSMFYSRREVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEY---- 213 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D Q++ P ++DV+ C NL GD +SD A Sbjct: 214 ----------------PDVELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAMI 257 Query: 317 VGGIGIAPGANIG-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A++ D ++E G+AP AG NP + ILSA +MLR+ + AA Sbjct: 258 TGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAAK 317 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + A++ +T D + SE GD I + + Sbjct: 318 AIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 116/398 (29%), Positives = 169/398 (42%), Gaps = 61/398 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 L + I GDGIG + + A+ ++ A I + EI Sbjct: 15 LKYGGKYTVTLIPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNKSS 67 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 L E + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G + Sbjct: 68 GDAL-HEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT 126 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D I REN+E Y+G+E ++ E +K Sbjct: 127 ---RHDNVDFAIIRENTEGEYSGLEHQSVPGVVE-----------------------SLK 160 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E +KR+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 161 IITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDA----- 215 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 I KD+I D Q + RP ++DV+ NL G +S+ +A VGG Sbjct: 216 ---------------ITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGG 260 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ PGAN G + ALFE G+ + NP + ILSA +MLRH+G + ADLI Sbjct: 261 PGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINA 320 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I D +F AI+E M Sbjct: 321 ATYSVIEEGK-----TLTKDLGGSASTGDFTHAILERM 353 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 111/392 (28%), Positives = 172/392 (43%), Gaps = 64/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V A + V+D + ++ G++ + +G L Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDEL-------DVDFDYIYGIAGDECNEEHGTP--L 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ET+D++R+ + G + V +RQE+ ++ LRPV+ Y T S Sbjct: 60 PQETIDIVRDSDACLFGAAG----ETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E D +I REN+E +Y + E I + + E Sbjct: 113 ENVDFMIVRENTEGLYIA-----------------------DQEEETEDGAIAKRVITRE 149 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R++ A +YA N+R VT VHK N++K T+G FK Y++ + Sbjct: 150 AEERIIDYAFQYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKY------------ 197 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I +D DA ++ +P E+ V+ NL GD +SD A VGG+G+ P Sbjct: 198 --------PDIDTEDFYVDATAMYLVTQPQEFQVVVTTNLFGDILSDEGAGLVGGLGLIP 249 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG + ALFE HG+AP AGQ K NP +++LSA MMLR++G +AAD + + Sbjct: 250 SANIGADGALFEPVHGSAPDIAGQQKANPIAMMLSAIMMLRYLGENDAADKFDAAILKVL 309 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D E A+ + Sbjct: 310 SEGK-----TLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 340 bits (873), Expect = 5e-92, Method: Composition-based stats. Identities = 106/399 (26%), Positives = 183/399 (45%), Gaps = 56/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +V PA +V++ K +++++Y G ++ Q G+ L Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSK---HGLSFNFIDLYAGFQTFQETGK--AL 76 Query: 85 PAETLDLIRE-YRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P ET+ +++E + A+ G + +P G S VALR+E+ L+ +RPV+ +G Sbjct: 77 PDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + DMVI REN+ED+Y IE K Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDK------------------ATGTRVADATKRI 173 Query: 202 SEEGTKRLVRAAIEYAIAN----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 SE T+R+ A++ A+ + ++T+ HK N++ ++G F++ ++ Sbjct: 174 SEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYE------- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 N + +I + I D+ + ++ P +DVI NL GD +SD AA V Sbjct: 227 ---------SNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALV 277 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G +G+ P AN+G E + E HG+AP AG+ NP + I S +ML +G EAA I Sbjct: 278 GSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIY 337 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ + ++ + D + D ++ + Sbjct: 338 KAVDANLREGSI-----KTPDLGGKASTQQVVDDVLSRL 371 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 111/397 (27%), Positives = 168/397 (42%), Gaps = 57/397 (14%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 ++VP I GDG+G ++ A+L ++ A +S + G + Sbjct: 5 SMSVP----ITVAYGDGVGPEIMEAVLFILKEARA-------DVSIETVDIGHNQYKKE- 52 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + + I R+ +K P TP G G +SLNVALRQ L LY+ +RP Y P Sbjct: 53 WTSGIAPSAWESISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPV 110 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+VI REN ED Y+G+E K E +K Sbjct: 111 VGTKHPDLDVVIIRENEEDTYSGVEHK-----------------------LSEDTHECVK 147 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + ++++ A YA A++R VT K NIMK T+G ++A+ Sbjct: 148 ISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGY------- 200 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I I D + +I P ++DV+ NL GD +SD ++ G Sbjct: 201 -------------PDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVSLSSGS 247 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 IG+ ANIGD A+FEA HG+AP AG++ NP ++ +A ML H+G + A +I Sbjct: 248 IGLTGSANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQLDKAGVIRNA 307 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D + EF AI+ N+ Sbjct: 308 FLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVGNL 344 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 340 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 105/399 (26%), Positives = 157/399 (39%), Gaps = 58/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDG+G +V A KV+ A E G S+ +G+ + Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAE--VHGGLSFSFTAFPWSCDYYLEHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + + ++ G + P + L + +R+EL+L I +RP + G SP Sbjct: 60 PEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSP 119 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + HP D V+ RENSE Y+ E+G + R + I Sbjct: 120 LLHPNDFDFVVIRENSEGEYS--------------------EVGGRIHRGDDEIAIQNAV 159 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + T+R++R A E A R VT K N + + + Q A + G Sbjct: 160 FTRKATERVMRFAFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSG------ 212 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I DA + RP +DVI NL GD ++D ++ +G I Sbjct: 213 --------------IETSSQHIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSI 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GIAP ANI ++FE HG+AP AGQ NP I +A++ML H G E I+ Sbjct: 259 GIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ME T D +E D I + Sbjct: 319 DVMEQVTADGIKTRDI------GGQSTTAEVTDEICSRL 351 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 116/413 (28%), Positives = 186/413 (45%), Gaps = 48/413 (11%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE----KSTQ 76 + + Y+ GD G D+ L V+ + I W+ G KS Sbjct: 9 KERKDRYKVCYMPGDDSGFDMMEGALVVL-------LSMDLPIDWVRADLGWCMWEKSVN 61 Query: 77 VYGQDV----WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPV 131 +GQ +P ET+D IR + +T+ G G +S + +RQ DLYI LRP Sbjct: 62 KFGQGDPRCNTVPPETIDKIRSSDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPA 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + SP+K D+V+FREN+ED+Y+ +E+ + + K G+++ R Sbjct: 122 KTLPDLGSPLKGDPKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHK------GMERFRKM 175 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + + S G +R++RAA EYA + R V +K N+++ T+G K ++A+E Sbjct: 176 GDVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKE 235 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 I + ADA ++ P +Y VI N+ GD +SD Sbjct: 236 YEQY------------------GITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSD 277 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG+G AP NIG+ A+FE G+ PKYA Q +VNP +++L+++MML ++G + Sbjct: 278 EASQLTGGLGFAPSGNIGENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLGLDQ 337 Query: 372 AADLIVKGMEGAINA---KTVTYDFERLMDGA-----KLLKCSEFGDAIIENM 416 A I + + KT+TYD R E AI + + Sbjct: 338 AGQKIEWAINEVLKENRPKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 99/405 (24%), Positives = 161/405 (39%), Gaps = 59/405 (14%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + I + GDGIG +V V+ A + + E+ G + + G V Sbjct: 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAG---SLEGLEFDFKEMPVGGAALDLVG--VP 98 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA------LRQELDLYICLRPVRYYQ-- 135 LP ET + + G + LR++L ++ LRP Sbjct: 99 LPEETFTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQL 158 Query: 136 --GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 + + E DM+I RE + IY G E G+ E Sbjct: 159 VDASTLKKEVAEGVDMMIVRELTGGIYFG------------------EPRGITINENGEE 200 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 G+ + + R+ R A E A R + V K N++ + ++ LA E Sbjct: 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEY- 257 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 ++ + + D Q++ P ++D I N+ GD +SD Sbjct: 258 -------------------PDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEA 298 Query: 314 AAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 + G IG+ P A++G+ LFE HG+AP AGQDK NP + ILSA M+L++ +G + Sbjct: 299 SMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEK 358 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I + A+N T D G KL+ C E G+ +++++ Sbjct: 359 AAKRIEDAVVDALNKGFRTGDIYSP--GNKLVGCKEMGEEVLKSV 401 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 98/407 (24%), Positives = 158/407 (38%), Gaps = 66/407 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVW 83 + I I GDGIGV+V P L+ +DA + + ++ I +GQ Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRR---FGLRFAYEPIEWASCDYYAKHGQ--M 93 Query: 84 LPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + G + P + + R+E D Y+ LRP R + G P Sbjct: 94 MPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 153 Query: 140 PV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ + D +I REN+E Y+ + G + Sbjct: 154 PLAGRKAGDIDFMIVRENTEGEYSAVG-------------------GTMFEGTEREFVVQ 194 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + GT+R+++ A E A +T+ K N + + + ++A Sbjct: 195 QAVFTRHGTERVLKFAFELAQRRA-KRLTVATKSNGIAISMPWWDARAAEMAARY----- 248 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ D + +++P +DV+ NL GD +SD A Sbjct: 249 ---------------PDVAWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACT 293 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----W 369 G IGIAP AN+ E +LFE HG+AP AG+ NP ++I SA MM+ +G Sbjct: 294 GTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPA 353 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EA D IV +E + T D E GDAI+ ++ Sbjct: 354 REAHDAIVAAIEHVLKHGPRTRDM------GGRASTREVGDAIVAHL 394 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 95/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 10 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE-- 60 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 61 ----DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 116 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 117 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 150 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 151 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 205 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 206 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 250 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 251 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 310 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE II ++ Sbjct: 311 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDIIRHI 345 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 338 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 62/397 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I GDGIG ++ A+ + + + E+ + + Sbjct: 47 YGGRNTVTLIPGDGIGPEMVVAVQDIFRHI-------GVPVDFEELNLSGLDIKDEDSYL 99 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 E + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + G + Sbjct: 100 GAFNEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT- 158 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 D+VI R+N+E Y+ +E + S E +K Sbjct: 159 --RHNNVDLVIIRQNTEGEYSHLEHENVSGVIE-----------------------NLKV 193 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +EE ++ + A ++A +DR VT VHK NIMK +G F +++ Sbjct: 194 TTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSY-------- 245 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I +I D Q++ P ++DV+ NL G+ +S+ A+ VGG Sbjct: 246 ------------PNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVSNIGASLVGGP 293 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 GI PG NIG + A+FE+ + T G+D NP S++ ++ +ML H+ +T ADLI Sbjct: 294 GIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLEHLEFTAYADLINSA 353 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + +T D ++F A+ + Sbjct: 354 ILKVVQRGVLTADV------GGSHTTTQFLSALKSEL 384 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 337 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 94/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 48 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE-- 98 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 99 ----DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 154 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 155 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 188 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 189 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 243 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 244 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 288 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 289 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 348 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE +I ++ Sbjct: 349 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDVIRHI 383 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 337 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 155/400 (38%), Gaps = 68/400 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG +VT A LKV+ A E +++ G + +G+ P Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDE---AEGLGLAYEVFPFGGAAIDAFGEP--FPEP 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP--S 139 T + E + G + P G + ++LR+ DL+ LRP + + G S Sbjct: 57 TRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLS 116 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K D++I RE + IY G A+ Sbjct: 117 PLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAE-----------------------AWN 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + S+ +R+ R A E A R V V K N+++ E ++ ++ R Sbjct: 154 TERYSKPEVERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ ++ DA ++ PA +DV+ N+ GD +SD + Sbjct: 207 ---------------PDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLP 251 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLI 376 G +G+ P A++G +FE HG+AP AG+ NP + ILSA MML H G E A + Sbjct: 252 GSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKV 311 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ D F ++ ++ Sbjct: 312 EDAVAKALLE-------TPPPDLGGSAGTEAFTATVLRHL 344 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 95/408 (23%), Positives = 160/408 (39%), Gaps = 66/408 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVW 83 + I I GDGIG++V P ++V++AA K + + +G+ Sbjct: 4 HSFRIAAIPGDGIGLEVLPEGIRVLEAAALK---HGLALEFDTFEWASCDYYLQHGK--M 58 Query: 84 LPAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + +++Y G + P + + R+E D Y+ +RPVR + G P Sbjct: 59 MPDDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPC 118 Query: 140 PVKHPE--LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + + D V+ REN+E Y+ + G+ I Sbjct: 119 ALANRKVGDIDFVVVRENTEGEYSSLG-------------------GIMFENTENEIVIQ 159 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G R+++ A + A +R VT K N M + + +A Sbjct: 160 ESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHY----- 214 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA-CMNLNGDYISDALAAQ 316 + D + +L+P +DV+ NL GD +SD A Sbjct: 215 ---------------PHVSWDKQHIDILCARFVLQPERFDVVVVASNLFGDILSDLGPAC 259 Query: 317 VGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-- 371 G IGIAP AN+ E +LFE HG+AP G++ NP ++I S +ML +G + Sbjct: 260 AGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDER 319 Query: 372 ---AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A D ++ +E I +VT D L + G AI + + Sbjct: 320 YQRAHDDMLNAIERVIADGSVTPDM------GGTLSTQQVGAAISDTL 361 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 336 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 99/402 (24%), Positives = 165/402 (41%), Gaps = 59/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG ++T + ++V++ EK +S+ G + +G LP Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEK---FGLGLSYTYKDAGGTAYDKFGTP--LP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTP- 138 +T++ + + G + + + LR+ L LY LRPV+ Sbjct: 57 DDTIEACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVE 116 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K + D+VI RE IY G + +++ + Sbjct: 117 YSPLKPELVKGVDLVIVRELIGGIYFGDKCESEQHNGA-------------------ERA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 ++ S R+ + A E A R VT V K N++ T ++ ++A Sbjct: 158 WDLENYSVPEVDRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESY--- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + ++ D Q+ +RP ++DVI NL GD +SD A Sbjct: 213 -----------------PDVELNNLYVDNCAMQLAIRPTQFDVIVTGNLFGDILSDEAAV 255 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G IG+ P A+IG +L+E HG+AP AG+ NP ILSA M+LR+ + AA Sbjct: 256 VGGSIGMMPSASIGTSTSLYEPIHGSAPDIAGKGIANPMGTILSAAMLLRYSLHEEAAAK 315 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I ++ A+ T D + +G + E I E + Sbjct: 316 AIEAAVDKALADGYRTPDLWK--EGFQKANTEEITKVICERI 355 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 100/399 (25%), Positives = 167/399 (41%), Gaps = 69/399 (17%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + GDG+G ++ + +V I + E+ ++S Sbjct: 62 KACYGGRHTVAMLLGDGVGPELLSYVKEVFQVI-------GAPIDFEEVAVNQESEDATF 114 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + L ++ V IKG T G S NVALR L+LY ++ R + G Sbjct: 115 T------DALLAMKRNGVGIKGNFAT--EPGQSSRNVALRLNLNLYAFVQRCRNFPGV-- 164 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V + D+VI REN+E Y+ +E + E +K Sbjct: 165 -VTRHQNVDIVIIRENTEGEYSRLEHENVPGVVE-----------------------SLK 200 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + E + R+ + A +YA+ ++R VT VHK NIMK +G F D +A+ Sbjct: 201 IITREKSTRIAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY------- 253 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I +I D Q++ +P ++DVI NL G+ + + A VGG Sbjct: 254 -------------PQIEFNHMIIDNTCMQLVTKPQQFDVIVLPNLYGNIVGNVAAGLVGG 300 Query: 320 IGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ G N+G + ALFE T + AG++ NP ++L++ ML ++G + A LI Sbjct: 301 AGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGMLLTSADMLEYLGHIKEAKLIRD 360 Query: 379 GMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I K T D K S+ +A+++++ Sbjct: 361 SVVDVIGEQKIRTADL------GGSFKTSKVIEAVLKSL 393 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 103/401 (25%), Positives = 158/401 (39%), Gaps = 61/401 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + I GDGIGVDVT +KV+D+A +I W E + G Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA------TGGRIEWTEFDYSCERYAKTG--A 52 Query: 83 WLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + + G + P + L + LR+ + Y+ LRPVR G S Sbjct: 53 MMPPDAPTTLAGFDAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIAS 112 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ E MVI REN+E Y+ I GV + Sbjct: 113 PLAGVSDEALSMVIVRENTEGEYSPIG-------------------GVHNRGNQNEFALQ 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G +R++R A E A + V K N + + + ++A E Sbjct: 154 ESVFTRIGCERIIRYAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEY----- 207 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + DA +++ PA DVI NL GD +SD AA Sbjct: 208 ---------------PQTPSVSMHVDALAARMVSDPASLDVIVASNLFGDILSDLAAAIT 252 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+A NI E ++FE+ HG+AP AGQ NP + IL+ M+L H+ A+ Sbjct: 253 GGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQILAGAMLLDHLNEPATAN 312 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 I ++ ++ V R D + G AI E Sbjct: 313 KIRLAVDQVLSDGRV-----RTPDLGGTATTEQLGTAIAEA 348 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 107/399 (26%), Positives = 179/399 (44%), Gaps = 41/399 (10%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +VT +KV++AA + G + Q L Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAG---SLFGFSLELTHYPYGAEHYLSTRQ--VL 56 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P L+ + + G + P G R + + LR D Y +RPVR + TP P+ Sbjct: 57 PDHALEEMEGLDALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSF--TPGPL 114 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI----KFLREEMGVKKIRFPEHCGIG 197 + V+ REN+ED+Y GI D A + ++ + P+ + Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQY----- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + ++ DA +++ P ++ VI C N+ GD +SD LA Sbjct: 227 ---------------ESVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIG 271 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP N+GD ++FE HG+AP AGQD+ NP + ILS M+LRH+G T AA + Sbjct: 272 GGMGLAPSGNVGDRLSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETSAAKAME 331 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ ++ E ++ L GDA++ + Sbjct: 332 DAVQRYLSG----PVEELPIEMGGRLGTRGAGDAVVRRL 366 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 135/393 (34%), Positives = 199/393 (50%), Gaps = 34/393 (8%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDG G ++ A V+D A + W G+ + + G+ L Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAA---GSAGFHLDWDVRPAGQGALRSVGE--LL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 PA TLD IR VA+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + Sbjct: 57 PASTLDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAV---D 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+Y+G+E+ ADS A V L E +KP + Sbjct: 114 SGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHA-----DPGIAFSLKPITPG 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G++R+V A+++A N R V + TEG F + +L E Sbjct: 169 GSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEY------------ 216 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +IV V ++ PA+ DV+ NL GD ISD AA VGG+G+AP Sbjct: 217 --------PDIVTATVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAP 268 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 GANIGD A+FEATHG+AP++AG +++NP ++ILS M+L H+G A I + + Sbjct: 269 GANIGDRTAVFEATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRSVL 328 Query: 385 NAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT+D A+ + + + +A+IE + Sbjct: 329 EEGRSVTFDLLPPDRAARAVTTTAYAEAVIERL 361 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 96/400 (24%), Positives = 176/400 (44%), Gaps = 60/400 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I IEGDGIG +V +K +++ + + + S+ + G K+ + +G +P Sbjct: 2 KKNIVVIEGDGIGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-P 138 ET+D + + G + P + LR+E+DLY +RP+ Y G Sbjct: 57 KETIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINK 116 Query: 139 SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP+K E + VI+RE + IY G + ++ + Sbjct: 117 SPIKERKLEGVNFVIYRELTGGIYFGKKGRSKNGK----------------------EAY 154 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 SE+ +R+ + + A + +R +TLV K N+++ T +++ ++A + Sbjct: 155 DYCVYSEKEIERIGEMSFKAARSRNRK-MTLVDKANVLE-TSRLWREVIQKMALDYS--- 209 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D QIL+ P ++DVI N+ GD +SD + Sbjct: 210 -----------------DVDLEFLYIDNAAMQILINPRKFDVILTDNMFGDILSDEASIL 252 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+ P A+IG + +LFE HG+ P+ G++ NP ILS MML + + +L+ Sbjct: 253 TSSLGLLPSASIGSKKSLFEPIHGSYPQAKGKNIANPLGCILSVSMMLEYFEMPQEKNLL 312 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ +I K T D ++D E GD I + + Sbjct: 313 EEAVKSSIQEKICTPDI--ILDDRNSSSTEEVGDYIEKYI 350 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 100/400 (25%), Positives = 175/400 (43%), Gaps = 41/400 (10%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + +P I GDGIG +V KV+ AA E + W+++ G+ + Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQE---VYNFDVEWIDMPFSADHYVKTGE--TIS 57 Query: 86 AETLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +L + +YR G + G + + + +R D Y+ LRPV+ +G +P+ Sbjct: 58 ESSLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCG 195 K D + REN+ED Y GI ++ +++ ++ +R+ + G+ + Sbjct: 118 KGKTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIA 177 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + S+EG KR++ + + A + + ++ V K N++ G +++ A + Sbjct: 178 YQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKY--- 234 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ DA + P +DV+ N+ GD I+D A Sbjct: 235 -----------------PDVKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAM 277 Query: 316 QVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+APG NI E ++FE G+APKY G +KVNP + I + M+L H+G +AA Sbjct: 278 IQGGLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGEKQAAA 337 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 IV +E + K + R D S+ G I Sbjct: 338 GIVDAIEQNLKEKKI-----RTYDLGGSAGTSDVGTDIAR 372 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 110/411 (26%), Positives = 165/411 (40%), Gaps = 78/411 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V PA + V+ A + G + Q G+ LP+ Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALPS 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 TL R + G + +P G RS V LR+ELDLY +RPV Sbjct: 57 ATLTAARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRR 116 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+YAG E D I + + Sbjct: 117 RKVDLVVVRENTEDVYAGRERVEDDGA----------------------TAIAERVITRR 154 Query: 205 GTKRLVRAAIEYAIAN---------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + R++R A + A A VT+VHK N+++ T G F+ ++A+ Sbjct: 155 ASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAY--- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ I +++ D Q+ RP +DVI NL GD +SD A Sbjct: 212 -----------------PDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACA 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD- 374 GG+G+AP AN+G+ ALFE HG AP AG+ NP + I ++L H+ AD Sbjct: 255 WGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADL 314 Query: 375 ---------LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + + A T D ++ +A++ +M Sbjct: 315 ASAMRGWSARIQRAIRHVRAAGPHTPDL------GGSAVTTDITNAVLSHM 359 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 332 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 97/398 (24%), Positives = 176/398 (44%), Gaps = 65/398 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDG+G ++T ++ + +A I W I + + + Sbjct: 23 KKYGGRFTVTLIPGDGVGKEITDSVRTIFEA-------ENIPIDWETINIKQTD---HKE 72 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 V+ E ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + Sbjct: 73 GVY---EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT 129 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D+++ REN+E ++G+E ++ E +K Sbjct: 130 RI---PDIDLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLK 163 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 164 VMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY------ 217 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q + +P ++DV+ ++ G + + AA +GG Sbjct: 218 -------------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ GAN G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K Sbjct: 265 PGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISK 324 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I T D ++F + II + Sbjct: 325 AVHETIAEGKHT-----TRDIGGSSSTTDFTNEIINKL 357 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 84/397 (21%), Positives = 151/397 (38%), Gaps = 64/397 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDG+G +V + +V+ + Y G + + GQ LP Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVE---RLYGHHFHLQDEYFGGVAIDLTGQP--LPQR 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTP--SPV 141 TL + G + P + +ALR+ L ++ +RPV T SP+ Sbjct: 59 TLAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPL 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 K+ + D V+ RE + IY + E Sbjct: 119 KNADEIDFVVVRELTGGIYFSYPKER-----------------------TEEVATDTLTY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +R+V A + A + VT + K N+++ + ++ ++A Sbjct: 156 HRHEIERIVSYAFQLANKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRY--------- 204 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 + ++ ++ DA +++ P +DVI NL GD +SD + G +G Sbjct: 205 -----------PNVEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLG 253 Query: 322 IAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKG 379 + P A+ ++ +L+E HG+AP AG++K NP +++ S MML G T I + Sbjct: 254 MLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEEA 313 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D + F A+I+ M Sbjct: 314 VSAVLKSGKCTADI------GGTETTTSFTKAVIQEM 344 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 330 bits (846), Expect = 7e-89, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 152/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG DVT A +V+ + ++ + G + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHS---GFTLTATPFPWSCAFYKETG--AMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PPDGIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + A + + Sbjct: 117 LK-AEGFDILCIRENTEGEYSGAGGRVHQGTA-------------------DEVAVETSI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R + A R + V K N K++ + + +LA E Sbjct: 157 FTRTGVERILRFGFDQARQRRRK-LASVTKSNAQKYSMVLWDEITRELAAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+ NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVVASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G AA ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLDHLGQARAARKVI 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E T + A++ + Sbjct: 316 EALERTTARGIGTVP--------GKNRTETITAAVLAAL 346 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 330 bits (846), Expect = 7e-89, Method: Composition-based stats. Identities = 95/395 (24%), Positives = 157/395 (39%), Gaps = 56/395 (14%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +V A + + AA+E ++ G + G +P + Sbjct: 9 RLAVIPGDGIGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAMPPD 63 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 DL+++ + G + P L + LRQ+LDL + LRPVR + G P+ V+ Sbjct: 64 AADLVKKTDAVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E Y G GV GI + S Sbjct: 124 DGVDLVIVRENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRR 164 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R A A + LV K N M++ + ++ + Sbjct: 165 AIERAAHQAFALAGRRS-GRLCLVTKSNAMRYGYPLWDRVVREVGEQY------------ 211 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++ V+ DA +++ P DV+ NL GD +SD A GG+G+AP Sbjct: 212 --------PGVELETVLVDAMAARMIQAPRSLDVLLASNLFGDILSDLAAVLAGGMGMAP 263 Query: 325 GANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 AN+ + ++E HG+AP AG+ NP + +LS M+L +G T+AA + + Sbjct: 264 SANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLLSGAMLLEDLGHTDAARRVRDAVA 323 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D ++ A++ M Sbjct: 324 DTLRDTRH-----HTADLGGNATTADVASAVLHTM 353 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 330 bits (845), Expect = 7e-89, Method: Composition-based stats. Identities = 98/411 (23%), Positives = 171/411 (41%), Gaps = 66/411 (16%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 PA+ K TL K + + + G GIG ++ + + G+ + + Sbjct: 30 PARCSKRTLHR-KSKIGGRFFVTLLPGHGIGPEMMRHVEAIF-------ACGKVPVDFET 81 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPL-TTPVGGGIRSLNVALRQELDLYI 126 I G + + IR VA+KG + TT + N+ LR +L+LY+ Sbjct: 82 IIVDAN----VGDASSM-DHAIKSIRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYV 136 Query: 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 + R + G + + D+V+ R+N+E Y+ +E + S E Sbjct: 137 NVVHCRNHPGINT---KHKGVDIVVIRQNTEGEYSCLEHEVTSGVVE------------- 180 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 +K + + ++ + EYA + R VT+VHK NIMK T+G F Sbjct: 181 ----------SLKIITWAKSFQIAKYCFEYARTHMRKKVTVVHKANIMKLTDGLFLKTCT 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++A+E +I + D+I D Q++ PA++DV+ NL G Sbjct: 231 EVAQEY--------------------PDIELNDIIIDNCCMQLVANPAQFDVMLVPNLYG 270 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + + + VGG G+ G N G E A+FE AT T G++ NP + + +A ML+ Sbjct: 271 NIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVATLYAAVDMLK 330 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+ + A +I + +E +N D D S+ + I++ + Sbjct: 331 HLELWDHAVVIRRAIEKTVNR-----DKVHTKDLGGDATTSKVVENILKEV 376 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 107/412 (25%), Positives = 169/412 (41%), Gaps = 73/412 (17%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 + + + +GDGIG ++ A + ++A I W ++ G ++ Q Sbjct: 26 QRAQSTQAHTVLTFDGDGIGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNT 78 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICL 128 G V++ +D E V KGPLT P S N R+ L+ + Sbjct: 79 G--VYIDDSHMDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANV 136 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RPVR G +P D+V+ REN+ED+Y G E D Sbjct: 137 RPVRSMPGVRAPF---NDVDLVVIRENTEDVYTGEETWVD-------------------- 173 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S ++R+ + +YA N R VT +HK N+ K ++G F + ++ Sbjct: 174 ---ADTVHCVKRISRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHER 230 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A I+ D +AD+ L ++++ P +DV+ C NL GD Sbjct: 231 AA------------------ATDLGGIIADDQLADSCLTKLMIEPKSFDVLCCPNLYGDL 272 Query: 309 ISDALA----AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 ++ VG +G+ P NIG ALFE HG+AP AG+ NP S ILS MML Sbjct: 273 VNPLSLRINRGMVGSLGLCPSGNIGTHQALFEPAHGSAPDIAGKGIANPTSQILSGCMML 332 Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G EA+ + + + V DF E A+++++ Sbjct: 333 SHLGEFEASQRLENALRAMYASGIVPVDF------GGQADTKEVVAAVLKHL 378 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 106/414 (25%), Positives = 171/414 (41%), Gaps = 70/414 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P++ + + + GDGIG ++ + K+ + Sbjct: 30 IQSPSKNQFARYGG-------RHTVTLLPGDGIGPEMLDIVQKIF-------TFANVPVD 75 Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELD 123 + E K T + I+ VAIKG + T +S NV LR+ LD Sbjct: 76 FEECQLDSKPT----SPESDLDNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLD 131 Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 L+ + P+ + ++V+ REN+E Y+G E + + E Sbjct: 132 LFANVLHCVSIPTIPT---RHKGINIVMIRENTEGEYSGHEHETVNGVVE---------- 178 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 +K C+ E +R+ R A +YAIA++R +T VHK NI K +G F Sbjct: 179 -------------SLKICTREKLERISRFAFDYAIAHNRKKITAVHKANIQKLADGLFLK 225 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++A +E+ I +I D Q++ RP ++D++ N Sbjct: 226 VVGEIAEKEY-------------------PSITFDSMIVDNASMQLVSRPQQFDIMLMPN 266 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEM 362 L G+ IS+ VGG G+ G NIGD+ A+FE T T AGQD NP + I + Sbjct: 267 LYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTAFIRAGVD 326 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ML ++G TE A+LI + AI K + D K S+ +A++ N+ Sbjct: 327 MLHYLGLTEYANLISDALFDAIVIKRL-----HTKDIGGTAKTSDVVNAVMRNI 375 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 108/416 (25%), Positives = 192/416 (46%), Gaps = 71/416 (17%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEK---AYKGERKISWMEIYTGEKS 74 N + + +I I DGIG +V PA ++V++AA+ K A + + + ++ + G ++ Sbjct: 23 NQQQIRLLSKVIGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWET 82 Query: 75 TQVYGQDVWLPAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPV 131 Q G+ LP ET++ ++ + AI G + +P G S VA+R+ +DLY +RP Sbjct: 83 FQKTGKS--LPVETVEALKNKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPC 140 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + + DM+I REN+E +Y E Sbjct: 141 QDL---------AKGIDMLIVRENTECLYIKKEKLTVDPT------------------TG 173 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDR---DSVTLVHKGNIMKFTEGAFKDWGYQL 248 E + + +E +KR+ A + A+ ++ VT+VHK N++ ++G F++ ++ Sbjct: 174 EKTAVADRLITERASKRIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEI 233 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 +++ ++ ++ + D+ + +++L P +YDV+ NL GD Sbjct: 234 SKKY--------------------PQVKTEEQLVDSMVYKMILDPTQYDVVVAPNLYGDI 273 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SDA +A VGG+G+ AN+ D AL E HG+AP G+ NP + I + M+LRH+ Sbjct: 274 LSDAGSAFVGGLGVTASANLSDSFALVEPVHGSAPDIFGKKISNPIATIRACAMLLRHLQ 333 Query: 369 W--------TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + KTVT D DAII+N+ Sbjct: 334 EKDPKCSYLNEIADSMDRAVNVVMPDKTVT-----TPDLGGKGNTETLVDAIIKNL 384 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 117/422 (27%), Positives = 186/422 (44%), Gaps = 61/422 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P + + GDGIG V P ++V++A +A I W + LP Sbjct: 3 RPTVVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECW---------CNEGNALP 53 Query: 86 AETLDLIREYRVAIKGPLTTPVGG---------------GIRSLNVALRQELDLYICLRP 130 T+ L+R++++ + G +T+ S V +RQ +L +C+RP Sbjct: 54 DRTIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRP 113 Query: 131 VRYYQGTPSPVKHP--------ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 + G P D+V+FR+N+E +YAG+EW + + ++ Sbjct: 114 CLSFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKF 173 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 E + ++ +++ +R+ AA ++A +VT+ K N+++ T G + Sbjct: 174 AAFANT-PGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMME 232 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + Q+ ++ EI + DA + P EY VI Sbjct: 233 EVAKQVQKQY--------------------PEIALWSTNIDAQTMWLTKNPEEYGVIVAS 272 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQD--KVNPGSIILSA 360 NL GD ISDA A VGG+G A NIGDE A+FE THG+APKYA + VNP ++ILSA Sbjct: 273 NLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSA 332 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGA-----KLLKCSEFGDAIIE 414 MML H+G +E AD I K + + TYD R+ G + DAI+ Sbjct: 333 AMMLDHIGESEKADRIRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILV 392 Query: 415 NM 416 ++ Sbjct: 393 HV 394 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 93/398 (23%), Positives = 167/398 (41%), Gaps = 69/398 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + V+ I + I ++S+ Sbjct: 82 SQYGGRYTVTLIPGDGIGPEMARHVKTVLHKC-------GAPIDFEVIDIKDESS----- 129 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ++ + +KG +TT +S+N +R++LDLY + P + G Sbjct: 130 ----TDAAIISLKRNGIGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGV-- 183 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+V+ REN+E Y +E + E +K Sbjct: 184 -WTRHGQVDLVVIRENTEGEYGSLEHENVDGVVE-----------------------SLK 219 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E+ ++R+ + A +YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 220 IITEKKSRRIAKFAFDYALQNNRRKVTAIHKANIMKLADGLFLETCREISKDY------- 272 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q++ P ++DV+ NL G+ +S VGG Sbjct: 273 -------------TDIEFESMIIDNCCMQMVTNPQQFDVMVMPNLYGNIVSHIGIGLVGG 319 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 IG+ PG NIGD+ A+FE+ G ++ NP + ++ +MLRH+G + AD+I Sbjct: 320 IGLVPGKNIGDKYAIFESGARNIGSDLVGLNRANPCGFLFTSALMLRHLGLDDYADIIES 379 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I R D ++F DA+I+ + Sbjct: 380 AVRTTIKNGKC-----RTPDIQGDRTTADFIDAVIKEI 412 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 328 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 89/401 (22%), Positives = 161/401 (40%), Gaps = 66/401 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG ++ L +++ K Y +I E G S +G+ L Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPS-- 139 +TL+ + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 EKTLNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLS 116 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G ++ + + Sbjct: 117 PLKAERVEGTDLVIVRELTSGIYFGEPRYFNNHE-----------------------ALD 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + E +R+V A + A + R +T V K N++ + ++ ++ Sbjct: 154 SLTYTREEIERIVHVAFKLAASR-RGKLTSVDKENVL-ASSKLWRKVVNEV--------- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ P ++DVI NL GD +SD + Sbjct: 203 -----------SQLYPEVTVNHLLVDACSMHLITNPKQFDVIVYENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ ++ L+E HG+AP AG++ NP +ILS M LR + +AAD Sbjct: 252 GSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + I T D L ++ + + + + Sbjct: 312 LEQHIYNMIEHGQTTADL------GGKLNTTDIFEILSQKL 346 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 101/393 (25%), Positives = 164/393 (41%), Gaps = 63/393 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G +V K +DA E I+W ++ G +G +PA+ Sbjct: 3 VVLLPGDGVGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADA 53 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KH 143 +D++R + + G + P + L + +RQELDL++ +RP R +G P P+ + Sbjct: 54 IDVLRGHDAILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRA 113 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 P DMV RENSE YAG+ + F I + Sbjct: 114 PHDVDMVFVRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFTR 154 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R++R A A A + + K N +F + + ++ E Sbjct: 155 RGCERVIRYAFGMASAR-KGVLVNATKSNASRFGFPFWDEIVAEVGAEF----------- 202 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 +V+ ++ DA +++ P DV+ NL GD ++D AA GG+G+A Sbjct: 203 ---------PGVVVDRMLVDALSARLIRDPGSVDVVVASNLFGDILTDIAAALQGGMGMA 253 Query: 324 PGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 AN+ ALFE HG+AP AG+ NP I SA +ML +G E + ++ + Sbjct: 254 ASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSAALMLEQLGAGEGSRRLMDAL 313 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E T D +E GDA++ Sbjct: 314 ETVCRRGPRTRDV------GGTATTAEVGDAVV 340 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 102/409 (24%), Positives = 165/409 (40%), Gaps = 68/409 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V PA L++V+AA A G + G L Sbjct: 6 DTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHN--AGAQYYAESGD--AL 61 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA TLD R+ + G + P G + LR EL L+ +RP+R++ G P Sbjct: 62 PASTLDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 141 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + P E D V+ RE +E ++ + Sbjct: 122 LTDPRAEQIDFVLVREQTEGLFYARGRGEIR---------------------NDEEAYDT 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + GT+R+ A + A R +VT V K N+ + + F+ ++A Sbjct: 161 MQITRSGTQRVTEFAFDIARQRKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRHS- 218 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ DA ++ +P +DV+ N+ GD +SD A Sbjct: 219 -------------------DLTKDHAYVDALALNMVKKPWTFDVLVTENMFGDILSDLAA 259 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG------ 368 +GG+G+AP A+IGD+ LF+ HGTAP AG+ NP ++ LSA MML + Sbjct: 260 GLIGGMGMAPSADIGDKHGLFQPAHGTAPDIAGKGCANPSAMFLSAAMMLDWLAAKFGQP 319 Query: 369 -WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA L+ +E ++ K M+ C+E ++I ++ Sbjct: 320 TLADAARLMEGAVEHTLSTK-----LAIPMEYGGNANCAEMTRSVISSL 363 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 326 bits (836), Expect = 9e-88, Method: Composition-based stats. Identities = 105/397 (26%), Positives = 170/397 (42%), Gaps = 62/397 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIGV+V K+ + I + G + G+ V P Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGKVV--P 60 Query: 86 AETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +D +++Y + G L P + +RQ+LD ++CLRP +++ G P+P+K Sbjct: 61 IDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLK 120 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+++ RENSE Y+ I G+ K P+ I + Sbjct: 121 KCE-IDILVVRENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHT 160 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R A E + R+ VTL K N MK+ + +A E Sbjct: 161 RRGLERVIRYAFEASRKR-RNHVTLATKSNAMKYGMVLWDSVFEAIAMEY---------- 209 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + DA +I+ P+++DVI NL D ISD G +GI Sbjct: 210 ----------PDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDIISDLTVTVAGSMGI 259 Query: 323 APGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 AP ANI E +LFE HG+A AG+ +P + ++ MML +G++E + LI + Sbjct: 260 APSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASSMMLEFLGYSEESVLIEEA 319 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +I K T D +E G+ I + + Sbjct: 320 IQSSILQKITTIDI------GGTKTTNEVGNFIADYI 350 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 161/405 (39%), Gaps = 57/405 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG++V A L V+ A + G + + G+ V P Sbjct: 7 RKRICVLPGDGIGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGETV--P 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR---------------SLNVALRQELDLYICLRP 130 A T +++ + G +T+ S + LRQ LDLY +RP Sbjct: 58 ARTWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRP 117 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 V G V+ REN+E +YAG+++ +++ + Sbjct: 118 VTDMTG-------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + + ++ + G R+ A EYA N VT V K +++ + + A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ DA ++ RP + VI N+ GD +S Sbjct: 231 RY--------------------PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILS 270 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370 D A +GG+G AP N G+ A FE HG+AP +AG +K NPG++ ++ +ML H+G+ Sbjct: 271 DLGAGVMGGLGFAPSGNFGNSGAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFP 330 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + I + + T TYD ++ G+AI++ Sbjct: 331 TESACISQAVSLVSRTSTRTYDL------GGSHTTAQVGEAIVQQ 369 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 96/397 (24%), Positives = 167/397 (42%), Gaps = 62/397 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I DGIG + +++V + + E Y + + + Sbjct: 40 ATYGGRHTVSLIPADGIGQSLIMGIVEVFQ-------NSGVPVDFEECYITGDTNEEKMK 92 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + + A+KG T +G +S NV LR +LDLY + + Y + Sbjct: 93 SF---NDIKTSVLRNGTALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSYP---TV 146 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+++ REN+E Y +E + E IK Sbjct: 147 ITRHNNVDLIVIRENTEGEYTNLEHENIPGVIEM-----------------------IKI 183 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +++ ++R+ + A +YA+ N+R VT VHK NIMK ++G F ++A Sbjct: 184 ITKKKSERIAKYAFDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGY-------- 235 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 EI D+I D Q++ +P ++DVI NL G+ +S+ AA VGG Sbjct: 236 ------------PEIDFNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAALVGGP 283 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ G N G+ +FE+ T + A ++ NP S++ +A +LRH+ ++ A LI Sbjct: 284 GLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSMLFAATALLRHLQLSKHAQLIESC 343 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + K VT + R +D SEF + +++ + Sbjct: 344 I-----HKIVTTNQARTVDIGGNTSTSEFFEILVKEV 375 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 86/408 (21%), Positives = 153/408 (37%), Gaps = 62/408 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + N I + GDGIG + T + K+++ + + + I E G + G Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKK---QFQINIVTTEHKIGGDAINSEGTP- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQ 135 P TL + + G + P ++ +ALR+ +L+ LRP+ Sbjct: 57 -FPKSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLAD 115 Query: 136 GTP--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 SP+ P D++ RE + IY G Sbjct: 116 ELKELSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGL------------------ 157 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 +R+ A + A R V+ + K N++ T +++ LA+ Sbjct: 158 -NEYAFDTAVYHRFEIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAK 214 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ ++ + D Q++ P+++D+I C NL GD +S Sbjct: 215 NY--------------------PDVELEHLYIDNASMQLINNPSKFDIILCPNLFGDILS 254 Query: 311 DALAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MG 368 D A G IG+ P A+I + L+E G+AP A ++ NP + ILS ++ R+ + Sbjct: 255 DECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIAHILSIALLFRYSLK 314 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I K + A+ T D + + K + +E GD I + Sbjct: 315 LDHIAIKIEKAVSQALMLGYRTIDIAKKHE--KSISTNEMGDIIAALI 360 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 323 bits (829), Expect = 6e-87, Method: Composition-based stats. Identities = 105/403 (26%), Positives = 174/403 (43%), Gaps = 61/403 (15%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + + + GDGIG ++ PA +K++D A G I+W E+ G + YG+ Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILD--AAVAAAGATPIAWTELPLGRSAIDEYGEHT- 77 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPS 139 P +TLD + E + GP + + + +R+ L+ +RP + ++G + Sbjct: 78 -PTKTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNA 136 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V E TD+VI REN+E YA A + + + I Sbjct: 137 IV---EGTDLVIVRENTEGFYADRNTFAGTGE----------------MMPTPDVAIMHG 177 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 178 IITRAATERIAHEAFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQY------- 229 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ I D DA ++ R ++DVI N+ GD +SD G Sbjct: 230 -------------PDVAINDFHIDAATVHLVRRADKFDVIVTENMFGDILSDLAGEVAGS 276 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EA 372 +GIAP N A+ +A+HG+AP AG+D NP ++ILS+ M+LR + A Sbjct: 277 LGIAPSINSSATHAMAQASHGSAPDIAGRDIANPIAMILSSAMLLRWLAAKFDDEKIARA 336 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD++ ++ + T D CS F DA++ Sbjct: 337 ADIVEAAVDLTVAEGATTPDM------GGTSSCSGFADAVVAA 373 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 323 bits (827), Expect = 1e-86, Method: Composition-based stats. Identities = 100/409 (24%), Positives = 161/409 (39%), Gaps = 63/409 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V + KV+ E G S +G + Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLN---SNKSLDFEIDEDLAGGCSYDKHGTP--I 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQG-T 137 E E + G + P + R +EL L+ LRP ++ Sbjct: 60 TDEVFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLV 119 Query: 138 PSPVKHPE---LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 + PE D++I RE + IY G E G+K I E Sbjct: 120 DASTLKPEIVSGLDIMIVRELTGGIYFG------------------EPRGIKPIENGERK 161 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 GI + R+ + A + A + VT K N+M+ + +K+ +L +E+ Sbjct: 162 GINTHSYTTSEIVRVAKVAFDLARKRS-NRVTSCEKSNVMEAGQ-LWKEEVQELHDKEYK 219 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ + ++AD Q+L P ++DVI NL GD +SD + Sbjct: 220 -------------------DVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQAS 260 Query: 315 AQVGGIGIAPGANIGDEC------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++G + A++E HG+AP AG++ NP + ILS M LR+ + Sbjct: 261 MLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSL 320 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + K ++ +N T D G K + S GDAII + Sbjct: 321 DLDSEADALEKAVQDVLNDGLRTKDILSQ--GKKEVSTSAMGDAIISKL 367 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 89/406 (21%), Positives = 153/406 (37%), Gaps = 64/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + + KV+ E G + +GQ + Sbjct: 5 KLLLLPGDGIGPEAMAEVRKVI---AFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDA 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ + G + P + + + LR+++ LY LRP Y Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 142 KHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 E D++I RE + +Y G + + + GI Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIID------------------LGNGQKRGID 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ A E A R+ VT + K N+MK Sbjct: 162 TQVYDTYEIERIADVAFELARTR-RNKVTSMEKRNVMK--------------------SG 200 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + ++ ++ ++ ++ADA Q++ P ++DVI NL GD +SD A Sbjct: 201 VLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFDVILTDNLFGDLLSDVAAMLT 260 Query: 318 GGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGW 369 G +G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ G Sbjct: 261 GSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASLAMCLRYSFGL 320 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + + G ++ T D +G + +E GDAI+ Sbjct: 321 VAEADRLEAAIAGVLDDGIRTADI--WSEGNTKVGTTEMGDAILAK 364 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 169/401 (42%), Gaps = 55/401 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P++ + + GDGIG +V +++++ E ++ + GE Q G+ Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE--YQRSGE-- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 LP D + G + P G + + LR+ L LY +RP+R Y Sbjct: 57 ALPQSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEAD 116 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 +P+K P D V+ RE++E ++ G + AD Sbjct: 117 TPLKGHGPGEIDFVLVRESTEGLFYGRDAIAD---------------------LEADEAT 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + ++R+ R A E A + +VTL+ K N++ + F+ ++A+E Sbjct: 156 NLLRITRSASERVCRLAFETARRRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFL-- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I + V DA ++ RP ++DV+ N+ GD +SD A Sbjct: 213 ------------------DIKAEHVYVDAAALFLVRRPQDFDVMVTENMFGDILSDLAAG 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+AP +IGD+ A+F+ +HG+AP AGQ NP ++ LS MML + E Sbjct: 255 LVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMMLEWLDHPET--R 312 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A A ++ +R D L E D I E + Sbjct: 313 RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAERL 353 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 172/402 (42%), Gaps = 60/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 N +EGDGIG ++ A + V+ AA++ + K++ + G S + + Sbjct: 3 NLKFLVLEGDGIGPEIAKASVDVLQAALK---LYDLKVNLVYEEIGFASLKKH--KTTFR 57 Query: 86 AETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +E L + + I G + P G + + +R+ DLY +RP + G Sbjct: 58 SEVLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF 117 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 P D ++ REN+E Y+ GV ++ I I+ Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNM----------------FKGVGELMPTPDVAISIRNI 159 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + +G+ R+ +YA+ R + +HK N++++++G F + Q++++ Sbjct: 160 TRKGSTRIAEIGFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKY--------- 209 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 E+ K+ I D+ ++ P+ +DVI NL GD +SDA + GG+G Sbjct: 210 -----------PEVEYKEQIVDSMSAMLIRDPSVFDVILATNLFGDNLSDAASEIAGGLG 258 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------WTEAAD 374 +A N G+ + +A HG+AP AG++ NP S+I S MML +G E A Sbjct: 259 LAESINAGENYCIAQAQHGSAPDIAGKNIANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQ 318 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I ++ I R D L ++F D +I N+ Sbjct: 319 MIEDAIDKTIIN-----PKTRTSDIGGNLSTTDFTDVLISNL 355 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 153/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG DVT A V++ + A G + G + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENG--SMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA+ ++ ++ + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PADGIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 ++ + D++ REN+E Y+G + I Sbjct: 117 LRS-DGFDILCIRENTEGEYSGAGGRIHQG-------------------ADNEVAIETAI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +G +R++R E A A R + V K N K++ + + + L+ E Sbjct: 157 FTRKGVERILRFGFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+A NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVAASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G T AA+ ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLEHLGETAAAEKVM 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E + +++ + Sbjct: 316 DAIETTTARGV--------GAIPGKDRTDAITASVLSAL 346 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 87/362 (24%), Positives = 151/362 (41%), Gaps = 54/362 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I GDGIGVDVT A ++V+ AA + G + +G+ + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAAK----GRFAFDTTSFPWSCEYYLEHGR--MM 55 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + G + P + L + +R+ + Y +RP R G P Sbjct: 56 PEDGIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGP 115 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + + Sbjct: 116 LK-AEGFDILCIRENTEGEYSGAGGRVHEGK-------------------GNEVAVETSV 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R E A + R +T V K N K++ + + +LA E Sbjct: 156 FTRAGVERILRFGFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEY-------- 206 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + + DA ++++ P + DV+ NL GD ++D AA GG+ Sbjct: 207 ------------PDVTVSHMHIDAMAAKMVMAPQDLDVVVASNLFGDILTDLGAAIQGGL 254 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP AG++ NP + I S ML H+G E + ++ Sbjct: 255 GFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAIWSVAQMLDHLGEAEVSAAVL 314 Query: 378 KG 379 Sbjct: 315 SA 316 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 317 bits (813), Expect = 5e-85, Method: Composition-based stats. Identities = 98/411 (23%), Positives = 161/411 (39%), Gaps = 62/411 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I + GDGIG++VT A L V + I W + Sbjct: 1 MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAA------ 54 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLY 125 +P+ T LI + G +T+ S + LRQ LDL+ Sbjct: 55 ---IPSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLF 111 Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 +RP P + I RENSE +Y G ++ K I L E Sbjct: 112 ANVRPCFSIDDQSKP------FNFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQH 161 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + + ++ S+ G RL A ++A+ VTL K N+++ + + Sbjct: 162 WQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIF 221 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 A+ +I + DA ++ P ++ VI N+ Sbjct: 222 ESTAQRY--------------------PKIQADILNVDAVALWLIKSPEKFGVIVAENMF 261 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GD +SD A +GG+G+AP ANIGD+ + FE HG+ P+ ++ NP ++ L+ M+L Sbjct: 262 GDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRI-RKNCANPSAMFLTISMLLN 320 Query: 366 HMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIEN 415 H G+ + A IV + I K +TYD ++ +A+IE+ Sbjct: 321 HFGYPDRAKKIVNAVMQVIKEKRFITYDL------GGHATTTDMANAVIEH 365 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 316 bits (810), Expect = 9e-85, Method: Composition-based stats. Identities = 89/409 (21%), Positives = 162/409 (39%), Gaps = 64/409 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + GDGIG +V + +++D + G + V + Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIA---SFETEHGLVGGAAYDA--DKVAIT 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTP- 138 T+ L + I G + P + + LR++L L+ LRP Y Sbjct: 58 DATMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAE 117 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 S +K E D++I RE + +Y G + + Sbjct: 118 ASSLKPEVVEGLDIMIVRELTGGVYFGEPKTITD------------------LGNGQKRA 159 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 I + +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 160 IDTQVYDTYEIERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYK- 216 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ ++ +AD+ ++ P ++DVI NL GD +SD A Sbjct: 217 ------------------DVQLEHQLADSGGMNLVKWPKQFDVIVTDNLFGDMLSDIAAM 258 Query: 316 QVGGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++ G A++E HG+AP AG+ NP +++ S M LR+ + Sbjct: 259 LTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGLANPVAMLASFGMALRYSL 318 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + T D + +G+ ++ S+ G+AI++ M Sbjct: 319 DMGELADKLDEAIAVVLARGLRTADIK--SEGSTVVSTSQMGEAIVQEM 365 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 110/398 (27%), Positives = 173/398 (43%), Gaps = 72/398 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I ++G+GIG ++T A ++V++A + W I +++ ++YG LP + Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQ 52 Query: 88 TLDLIREYRVAIKGPL-------------TTPVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I++ + IK PL T S+N A+R+EL+L++ RP+R Y Sbjct: 53 VIQRIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGY 112 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G E DMVI RE +ED Y G E + A Sbjct: 113 VGISG---RHEKMDMVIMREITEDTYIGWEKPLEDGAA---------------------- 147 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK + + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 148 AEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLY-- 205 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 +IV D++ DA ++ P +DV+ +N GD SD A Sbjct: 206 ------------------PDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDIFSDLAA 247 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+APGANIGD + FEA HG AP AG NP ++ILS +L H G+ + ++ Sbjct: 248 GLAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHAGYGKGSE 307 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 I + + I A D + DAI Sbjct: 308 AIREAVTRVIEAGR-----TLTPDLGGRSTTEQVADAI 340 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 158/400 (39%), Gaps = 66/400 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG ++ L+++ EK + + + G S YG L Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYH---FEYHLESHHFGGVSIDYYGTP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTP--S 139 ETL + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 NETLQSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLS 116 Query: 140 PVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G +A +K Sbjct: 117 PLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLK-------------------- 156 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S + +R+VR A A R +T V K N++ + ++ + ++ Sbjct: 157 ---YSSQEIERIVRIAFNLANRR-RKKLTSVDKENVL-SSSKLWRQIVNDVKKDY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ +P ++DVI NL GD +SD + Sbjct: 207 ---------------PEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ G L+E HG+AP A +DK NP ++LS + LR + +AA+ Sbjct: 252 GSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + I + T D + SE + E Sbjct: 312 LESIVYSFIQSNKTTADL------GGQYRTSEIFKLLKEK 345 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 315 bits (808), Expect = 2e-84, Method: Composition-based stats. Identities = 100/390 (25%), Positives = 167/390 (42%), Gaps = 66/390 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P I I GDG+G ++ A++ V++ + + G+++ + G V LP Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSD---LMNLPLDLRFFEAGDETKRKRG--VALPE 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ETL+ + + + R + + LRQ+LDLY+ LRP + Y + Sbjct: 57 ETLNGVMNSDATLMVAIG----ESAREVILPLRQKLDLYVNLRPAKSYP----VPRAIPG 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+ I REN+ED+Y W+ + ++ + + Sbjct: 109 FDLTIVRENTEDLYVMSGWR------------------------GLDTAVDLRIITRRAS 144 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R YA + V +VHK N++ F++ ++A EE Sbjct: 145 ERICRFGYRYARERGKSRVYVVHKANVLG-GCMLFREVCSRVAEEEGFD----------- 192 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +++ D+ +I + +DVI N+ GD +SD AA +GG+G+ P A Sbjct: 193 ----------YREMYVDSAAMRIAMDRP-FDVIITTNMFGDILSDLAAAFIGGLGMYPSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+ A+FE HGTAP+ AG++ NP + ILSA MM+ +G + LI + + A Sbjct: 242 NIGESRAIFEPVHGTAPEIAGKNIANPMATILSAAMMMGWLGHEGGSKLIEEAVRRACEL 301 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D ++ E G I E M Sbjct: 302 GYTTPDV------GGSMRTKEVGLKISEIM 325 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 314 bits (804), Expect = 5e-84, Method: Composition-based stats. Identities = 77/402 (19%), Positives = 160/402 (39%), Gaps = 64/402 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG +++ ++V+ A EK K+++ G + G P Sbjct: 2 DFKIAVLAGDGIGPEISVQGVEVMSAVCEK---FGHKVNYEYAICGADAIDKVGDP--FP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT- 137 ET + + + + P +A+R++L L+ +RPV+ ++ Sbjct: 57 EETYRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLV 116 Query: 138 -PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D + RE + +Y G +++ Sbjct: 117 HKSPLRAELVEGADFLCIRELTGGMYFGEKYQ------------------------DNDK 152 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 153 AYDTNMYTRPEIERILKVGFEYAMKR-RKHLTVVDKANVL-ASSRLWRQIAQEMAPQY-- 208 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 E+ + D +++ P +DV+ N GD ++D + Sbjct: 209 ------------------PEVTTDYMFVDNAAMKMIQEPKFFDVMVTENTFGDILTDEGS 250 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+ P A+ G+ +FE HG+ P+ G + NP + ILS M+ + Sbjct: 251 VISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYFDCKAEGA 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LI K ++ +++A T + + ++G + E G I++ + Sbjct: 311 LIRKAVDASLDANVRTPEIQ--VEGGEKFGTKEVGAWIVDYI 350 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 97/395 (24%), Positives = 154/395 (38%), Gaps = 48/395 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + DGIG ++ A ++V+ +A + +++ G S + YG L E Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSAD---SVFKLDLAFDYDDVGFTSLEKYG--TTLRDE 56 Query: 88 TLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L + Y I G G R+++ R LDLY +RP R S ++ Sbjct: 57 VLAKAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMRE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI RE +E Y A+ + I ++ + Sbjct: 117 GRTMDLVIMREATEGFYPDRNMTKGWAE----------------LMPSPDMAISLRKITR 160 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 ++R+ R A E A+ + VT +HK N T+G F + +AR+ Sbjct: 161 HCSERIARRAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDF----------- 208 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 E+ + D++ DA ++ P +DV+ N GD ISD + G +G+A Sbjct: 209 ---------PEVRLDDLLIDASTAHLVRAPERFDVLVATNFYGDIISDLASELSGSLGLA 259 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA--ADLIVKGME 381 D +A HG+AP AGQDK NP S+ILS M+++ MG A L Sbjct: 260 GSMMASDTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQWMGEHHQNPAYLAAAQAM 319 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + R D C FG + + + Sbjct: 320 EAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKVI 354 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 88/390 (22%), Positives = 158/390 (40%), Gaps = 73/390 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK-ISWMEIYTGEKSTQVYGQDVWLPAE 87 + I G GIG ++T ++ V +A ++ + Sbjct: 35 VTLIPGVGIGPEITNSVKTVFEALHVPIKFDVLDNFNFE------------------NDD 76 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + +R+ + G + T N + LDLY + +G + T Sbjct: 77 SKSQLRKNECILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNNT 131 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E Y+G+E + E IK +++ + Sbjct: 132 DIVVIRENTEGEYSGVEHEVYPGVVE-----------------------SIKVTTKQASL 168 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A E+A + R VT VHK NIMK +G F ++A+ Sbjct: 169 RIAEYAFEFAHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSF------------- 215 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I +++I D Q++ P ++DV+ NL G + + +A GG+G+A GA+ Sbjct: 216 -------IKYEEMIIDNCCMQLVKNPTQFDVMVMPNLYGSIVQNVVAGITGGVGMAAGAS 268 Query: 328 IGDECALF-EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG + ALF + T AG++ VNP ++++S+ ++LRH+G AD I + ++ I Sbjct: 269 IGKDHALFSQGCRHTGRDIAGKNVVNPSAMLVSSTLLLRHLGLPNFADQICRAVQHTIQD 328 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D +F +I ++ Sbjct: 329 KKI-----KTKDIGGNATTDQFTSEVIRSL 353 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 101/394 (25%), Positives = 166/394 (42%), Gaps = 71/394 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDG+G ++ A L +++ ++EI G+ G+ + Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLE--------RYIGADFIEIKAGKSYFIEEGKP--IEDN 51 Query: 88 TLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ++ IRE +KGP+ TP G S+N LR+E LY +RP R Y+G Sbjct: 52 AIEKIRECDSLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISIR-----R 106 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D ++ REN E +Y G E + E I ++ ++ G Sbjct: 107 IDTILVRENLECLYYGWEVE------------------------DEDRAIAMRVITKRGA 142 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ A A R VT +HK NI+K T+G F D Y++A + Sbjct: 143 ERISEFAFNLAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-------------- 188 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ D I DA +++ +DV+ NL GD +SD A VG IG+ A Sbjct: 189 -------DLRADDEIVDAAGYKLVKLDNAFDVMLTPNLYGDILSDVAAGVVGSIGLCGSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW----TEAADLIVKGMEG 382 IG++ A FE HGT AG+ NP +I++A MML + + + I + ++ Sbjct: 242 QIGEDFAAFEPIHGTGEDIAGKGVANPIGMIIAASMMLDWLWERGRSPKRGEKIREAVDS 301 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +T D + + + I++ + Sbjct: 302 VIRDRILTPDL------GGDFRTEQVVEKIVDRL 329 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 104/399 (26%), Positives = 166/399 (41%), Gaps = 60/399 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GD IG ++ P ++V+ AA + I W +I G + G LP Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAAR---TGLAIEWQDIPIGRAALDSLG--STLPDG 56 Query: 88 TLDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 T++ + + GP+ P + + LR+ DL+ +RPV+ + P Sbjct: 57 TIERLDALDGWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---H 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E A S + R I ++ + Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGE----------------FRPTPDVTISVRVITRN 157 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G+ ++ RAA E A A R +T VHK + K G F + +LA E Sbjct: 158 GSSKVARAAFELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEY------------ 204 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + I D F ++++ P YDV+ N+ GD ++D A VGG+G+A Sbjct: 205 --------PDVTYDEAIVDTFAMRLVMTPQRYDVVVTTNMFGDILTDEAAGLVGGLGMAA 256 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLIV 377 G G A+ +ATHG+AP AG+ NP ++I+S +M+L +G AA LI Sbjct: 257 GLCAGPRHAMAQATHGSAPDIAGRGIANPYAMIMSGQMLLDWLGRRHAEPAATAAARLIE 316 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + I + D + G AIIE M Sbjct: 317 QAVANMIEERR-----ALTPDLGGQGTTAGMGSAIIEAM 350 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 87/403 (21%), Positives = 155/403 (38%), Gaps = 64/403 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG + + K++ E G E G + +G + + Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAG---FVTDEGLVGGCAYDAHG--AAISEADMQ 62 Query: 91 LIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + G + P + + + LR++L L+ LRP Y S Sbjct: 63 KALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLK 122 Query: 145 ----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D++I RE + +Y G + + + GI + Sbjct: 123 PELVEGLDILIIRELTGGVYFGEPKEIID------------------LGNGQKRGIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ A E A ++ V + K N+MK + + + + ++ Sbjct: 165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMK-SGVLWNQVVTETHKAKYS------ 216 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ ++ ++ADA Q++ +P ++DVI NL GD +SD A G + Sbjct: 217 -------------DVQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ + Sbjct: 264 GMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNMVKE 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + K + ++ T D DG + + E G+AI+ Sbjct: 324 ADDLEKAIANVLDKGIRTGDIM--ADGCRQVGTVEMGEAILAE 364 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 94/397 (23%), Positives = 167/397 (42%), Gaps = 64/397 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 V + + + GDG+G ++ A+ +V AA E +S ++ E+ Sbjct: 45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL------- 97 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G Sbjct: 98 ---EQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGY--- 151 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+VI RE +E Y+ +E ++ E +K Sbjct: 152 MTRHNNLDLVIIREQTEGEYSSLEHESARGVIE-----------------------CLKI 188 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + ++R+ + A +YA R VT VHK NIMK +G F ++A Sbjct: 189 VTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY-------- 240 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I + +I D Q++ P ++DV+ NL G+ I + A VGG Sbjct: 241 ------------PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGA 288 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ PG + E A+FE + G++ NP +++LSA MLRH+ + +I Sbjct: 289 GVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ I R D ++F ++I ++ Sbjct: 349 VKKVIKVGK-----VRTRDMGGYSTTTDFIKSVIGHL 380 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 87/419 (20%), Positives = 153/419 (36%), Gaps = 73/419 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD IG ++ +KV+ ++ + G S +G V Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIE--THRPNLHFNLTTDLVGGTSIDTHG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG----GGIRSLNVALRQELDLYICLRPV-RYYQGT 137 + LD + + G + P S + LRQ LD + LRP Sbjct: 57 PITQSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSL 116 Query: 138 --PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP++ + T ++ REN Y G + + E Sbjct: 117 VGASPIREHVVKGTRFIVVRENCGGAYFGEKKEE------------------------ED 152 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGY 246 + + +RL R + A R +V K N++ + ++ Sbjct: 153 VASDLWVYTRPEIERLARVSAAVARIMGRSEDDNQAATVWSADKANVL-ASGRLWRRITS 211 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLN 305 + +EF +I ++ +AD+ ++ P ++ VI N Sbjct: 212 DIFAKEF-------------------PDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTF 252 Query: 306 GDYISDALAAQVGGIGIAPGANIGD-------ECALFEATHGTAPKYAGQDKVNPGSIIL 358 GD +SD A G +G+ P A++ ++E HG+AP +G+ NP + IL Sbjct: 253 GDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQIL 312 Query: 359 SAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 S MMLR+ MG + A + + + ++AK+ R D CS+ GDA+ E + Sbjct: 313 SVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCEVL 371 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 310 bits (795), Expect = 5e-83, Method: Composition-based stats. Identities = 105/400 (26%), Positives = 165/400 (41%), Gaps = 61/400 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG +V LKV+ A + + E G + G+ L Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPR---HGLTLDTTEYELGAQRWHATGE--VL 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P + +R++ + G + P R L + LR Y+ LRPVR Y G +P+ Sbjct: 59 PDAVEEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPL 118 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 PE DM++ RE +E YAG+ GV + P Sbjct: 119 AGVAPEDIDMLVVREGTEGPYAGMG-------------------GVLRKGTPHEIATQDS 159 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R+VR A A +TLVHK N++ + ++ ++ E Sbjct: 160 VNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEY------- 212 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + + DA + +P +DV+ NL GD I+D AA GG Sbjct: 213 -------------PQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGG 259 Query: 320 IGIAPGANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 IG+A NI GD ++FE HG+AP AGQ K +P + ILS +ML H+G+ +AA I Sbjct: 260 IGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGYADAAAQI 319 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D + + ++ GD I + + Sbjct: 320 DQAVAE---------DLQERAKNGGVRSTTQIGDDIAQRV 350 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 310 bits (794), Expect = 6e-83, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 163/404 (40%), Gaps = 63/404 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + + GDGIG +V L+V+ AV + + + G GQ Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPA----DVSLDTTQYPFGAGHFLETGQ-- 54 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 L L + ++ + G + R L + LR D YI LRP Sbjct: 55 ILTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLP 114 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G SP+ P D V+ RE +E YAG GV + Sbjct: 115 GVASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIA 155 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + G +R VR A E A DR VTLVHK N++ F ++ ++A E Sbjct: 156 TEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAE---- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + DA + ++ P+ +DVI NL GD I+D AA Sbjct: 212 ----------------HPDVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAA 255 Query: 316 QVGGIGIAPGANIGDECA---LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 GGIG+A N+ A +FE HG+AP AGQ K +P + ILS ++L H+G +EA Sbjct: 256 ISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEA 315 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + + A T D +E GDAI+ + Sbjct: 316 AARVSAAVSDDLAA-RATGDAAPR-------STAEVGDAILRAL 351 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 309 bits (792), Expect = 1e-82, Method: Composition-based stats. Identities = 101/413 (24%), Positives = 159/413 (38%), Gaps = 74/413 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V+ A ++V+ A+ I + + G + + G Sbjct: 11 DGYRIAVVPGDGIGPEVSAATVRVLTQAL----GTSFPIEFRDYDAGAECFRRTG--TAF 64 Query: 85 PAETLDLIREYRVAIKGPLTTPV------GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 P T R+ + G P + ++ +R LDLY +RP+R +G P Sbjct: 65 PEATQVACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAP 124 Query: 139 SPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + K P+ I REN+E +YA Sbjct: 125 RRLVGKGPDDIRFTIVRENTEGLYAARGGGN---------------------IIRGQIAT 163 Query: 197 GIKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + EG +R+VR A E A A+ VT+V K N+++ + F++ + Sbjct: 164 DTLVMTREGVERIVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIADGVLA 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + I ++ VI DA ++ RP +DVI C NL GD +S Sbjct: 223 D--------------------CPGIEVEHVIVDAMTVHMIERPEHFDVIVCENLFGDILS 262 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-- 368 D AA +GG+G+AP IG + F+ +HG+AP AG+ NP + ILS MML +G Sbjct: 263 DLGAAIMGGMGLAPSGEIGRDHGYFQGSHGSAPTIAGKGLANPIACILSGAMMLDWLGKR 322 Query: 369 -----WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA+ I + + A D I + Sbjct: 323 HSDPALTRAAERIREATGAVLKAGR-----AVTPDIGGSGSTESCAAEICATL 370 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 98/405 (24%), Positives = 159/405 (39%), Gaps = 78/405 (19%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 ++ + + GDGIG +V +++A E + + EI G + +G Sbjct: 6 AKDSYQVVLLPGDGIGPEVMAQARDLLEAVAEPS---GVRFELDEIPCGGRFYLEHGARD 62 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRP 130 W P + R V + G + P G S + R +LDLY +RP Sbjct: 63 W-PEDAEARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRP 121 Query: 131 VRYYQGTPSPVK-------HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 V+ G + PE DMVI REN+E +YAG+ + + V Sbjct: 122 VKLLPGVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASV-------- 173 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKF 236 + + G +R++R A E R VT + K N+++ Sbjct: 174 -----------ATDTRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE- 221 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 F + ++A E +I + I DAF Q ++ +P Y Sbjct: 222 GCKLFAEVFAEVASEY--------------------PDIANELAIVDAFTQWLVTQPEHY 261 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSI 356 DV NL GD ++D + GG+G+A G N+GDE A+FE HG+AP AG+D+ NP ++ Sbjct: 262 DVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEHAMFEPIHGSAPPLAGKDEANPMAM 321 Query: 357 ILSAEMMLRHMGWTE-------AADLIVKGMEGAINAK-TVTYDF 393 +L+ L +G A + + + +T D Sbjct: 322 LLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVDL 366 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 106/391 (27%), Positives = 158/391 (40%), Gaps = 74/391 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +V ++V+ A + + + G Q G + Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR-------VRFEYYEGGVDVFQECGSP--IRE 52 Query: 87 ETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E L+ IR + G TTP G RSL + LR+EL LY LR + Sbjct: 53 EDLEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLR---IIPDLRT------ 103 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 ++VI RENSE +Y GI + + ++ + EG Sbjct: 104 GREIVIVRENSEGLYFGIGAVVNG------------------------RAVDVRLITREG 139 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 +R+ R A+E A A +T VHK N++ + F+ ++A EE Sbjct: 140 AERIARFAVEQAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE------------- 184 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + ++D I D+F +++ P E+ VI NL GD +SD G IGI P Sbjct: 185 --------GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVPS 236 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 N GD ALFE HG+AP AG+ NP ILS M+L ++G LI + G + Sbjct: 237 GNYGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLGLD--GSLIRAAVRGYVV 294 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D + + II + Sbjct: 295 NGELTPDM------GGRARTEDVVRGIIGEI 319 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 305 bits (782), Expect = 2e-81, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 168/401 (41%), Gaps = 63/401 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ A ++V+DA E + R ++EI G + + G V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTG--VACAEA 61 Query: 88 TLDLIR-EYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + +R E +KGP+ TP G L LR LD Y +RPVR + G PS V Sbjct: 62 DVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRV 121 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + D VI REN+E +YA Sbjct: 122 -RADRVDYVIVRENTEGLYASRGKGVG----------------------NRWAVTDTLLT 158 Query: 202 SEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + EGT R+ R A A VT V K N+++ + F++ ++A E Sbjct: 159 TREGTLRVARKAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEF--- 214 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 E+ ++ ADA Q ++L P +DV+ N GD +SD A Sbjct: 215 -----------------PEVELEYRYADAAAQDLVLCPERFDVLVMENFLGDVLSDLGGA 257 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+ P N+GD A FE HG+AP G+++ NP +L+A M+L H+G + A Sbjct: 258 TVGGVGLCPAGNVGDGAAYFEPVHGSAPDLVGRNRANPVGQLLAAAMLLDHLGHVDEAAR 317 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + + TV + + + G DA+I + Sbjct: 318 LRRAVSAVLAFGTVRIEADGTVLGGA----EAVADAVIAAL 354 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 305 bits (782), Expect = 2e-81, Method: Composition-based stats. Identities = 109/393 (27%), Positives = 176/393 (44%), Gaps = 65/393 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG--QDVW 83 + ++GDGIG +V +ML+V+ + + G + G + Sbjct: 2 SKKAAVMKGDGIGPEVVDSMLRVLKEC-------NFQSELILCEAGSEQWDKNGRKDASY 54 Query: 84 LPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 +P T+ ++ E KGP TT PV G RS+ V LRQ+ DLY +RP + Y + Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYD----RLT 110 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D V FRE +E +Y G+E + + I I+ + Sbjct: 111 PDRKLDCVCFREATEGLYTGVE-----------------------AKITDDAAIAIRKIT 147 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +G++RL+ +A+++A + + V K NI+K T+G F Sbjct: 148 RQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGIF--------------------- 186 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGI 320 W + + G +I + ++ D QQ+++ +++ V+ NL D IS+ +A VG I Sbjct: 187 WDETQKAVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELASALVGSI 246 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ ANIGD A+FEA HG+AP++AGQ+KVNP + +LS M ++G + D I Sbjct: 247 GLIYSANIGDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMADYLGERDVRDAIFAAT 306 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E IN D ++ DAII Sbjct: 307 EQVINEGK-----AVTWDIGGDASTTQMTDAII 334 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 305 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 95/412 (23%), Positives = 163/412 (39%), Gaps = 65/412 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I ++ GDGIG +V + +V+D G + G + G + Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLN---QTGRTAFEVEDALVGGAAYDAQGTPL 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 +T+ L + G + P + LR++L+L+ LRP + Sbjct: 58 H--DDTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFD 115 Query: 136 GTPSPVKHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 D++I RE + +Y G + G+ + Sbjct: 116 ALAEASTLKTELVSGLDVMIVRELTGGVYFG------------------QPRGISALPNG 157 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E G+ + R+ + A + A + V K N+M+ + +++ +L + Sbjct: 158 ERRGVNTQVYDTHEIVRVAKVAFDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGAD 215 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 EI + + AD Q++ +P ++DVI NL GD +SD Sbjct: 216 Y--------------------PEIALSHMYADNCAMQLVRQPKQFDVIVTDNLFGDILSD 255 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 A G +G+ P A++ G+ A++E HG+AP AGQDK NP + ILS MMLR Sbjct: 256 CAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDKANPLATILSFSMMLR 315 Query: 366 H-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E ADL+ + G + T D + G L+ + GDA++ M Sbjct: 316 YSFDLAEEADLVDNAVRGVLAKGLRTGDIFQP--GKTLVGTTGMGDALLAEM 365 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 305 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 97/399 (24%), Positives = 162/399 (40%), Gaps = 65/399 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + G GIG + + + I + + Sbjct: 50 KAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYI-------GAPIDFEVVDI-----DPTM 97 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTP 138 + + I+ V +KG + T S NVALR ELD+Y + + Y G Sbjct: 98 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 157 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + D+VI R+N+E YA +E ++ + E + Sbjct: 158 T---RHKDIDVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SM 191 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K + + ++R+ R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 192 KVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY------ 245 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 +I D+I D Q++ +P ++DV+ NL G +S+ + +G Sbjct: 246 --------------PDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLG 291 Query: 319 GIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G G+ G N GD A+FE T T AG++ NP ++I ++ ML H+G A L+ Sbjct: 292 GAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEHLGHQFHASLLR 351 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + IN D D ++ AI++N+ Sbjct: 352 RAINKTIN-----VDRVLTPDLGGSNTSTDVVGAILQNV 385 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 88/406 (21%), Positives = 164/406 (40%), Gaps = 63/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIGV+V + +++D K + + E G + V+G PAE Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPY--PAE 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-PSP 140 TL+ + G + P + + +R+++ L+ LRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 141 VKHPE---LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 E D++I RE + +Y G + G+ + G Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFG------------------QPRGIDTLPDGTRKGYN 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ R A + A + + V K N+++ T +++ +L +EEF Sbjct: 162 TLVYTTPEIQRIGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEF---- 215 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ + + D Q++ P ++DV+ N+ GD +SD A Sbjct: 216 ---------------PDVELTHMYVDNAAMQLVRNPKQFDVMVTENMFGDILSDCAAMLT 260 Query: 318 GGIGIAPGANIGD------ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 G +G+ P A++G+ AL+E HG+AP AG+D NP + I+S M LR+ Sbjct: 261 GSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANPLATIMSFAMCLRYSFDMA 320 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI ++ + T D + G + + G+A++ + Sbjct: 321 AEADLIETAVKNVLKGGLRTADIMQP--GKAKVSTTVMGEAVVREL 364 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 85/412 (20%), Positives = 155/412 (37%), Gaps = 71/412 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD +G ++T +KV+ A + + K + G + G V Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVR-----Y 133 LP E L+ ++ + G + P G + +R+EL LY LRP Sbjct: 57 PLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSL 116 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +P + + TD V+ RE IY G + D + Sbjct: 117 LDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDG----------------------DG 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ R A A+ ++ + + K N++ + ++ + + E Sbjct: 155 VAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVL-ASSRLWRKTVEETIKNE 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISD 311 F + ++ + D+ ++ P + +I N+ GD ISD Sbjct: 214 F-------------------PTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISD 254 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + G +G+ P A++ L+E HG+AP ++KVNP + ILSA MML+ Sbjct: 255 EASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-PKNKVNPIATILSAAMMLK 313 Query: 366 -HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E I ++ ++A T D +E GDA+ E + Sbjct: 314 LSLNLPEEGKAIEDAVKKVLDAGIRTGDL------GGSNSTTEVGDAVAEEV 359 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 301 bits (771), Expect = 3e-80, Method: Composition-based stats. Identities = 102/388 (26%), Positives = 155/388 (39%), Gaps = 60/388 (15%) Query: 39 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 97 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 98 AIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVIF 152 + G L P + R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 212 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 213 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTG 272 A +YA AN R VT+ K N M+ + +++ + Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEVRAQY-------------------- 214 Query: 273 KEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-- 330 EI V DA ++ P ++ VI NL GD ++D AA GG+G+A AN+ Sbjct: 215 PEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGAALQGGLGMAASANVHASD 274 Query: 331 --ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 ALFE HG+AP AG+D NP + +L+A ++L H+GW E I + + A++ Sbjct: 275 PARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLGWPEEERRIERWVSQALDQGM 334 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D L G + E + Sbjct: 335 CTVDV------GGTLGTRAAGAWVREQI 356 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 300 bits (769), Expect = 6e-80, Method: Composition-based stats. Identities = 100/394 (25%), Positives = 158/394 (40%), Gaps = 68/394 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + + GDGIG +V A + A A + + + E G + + G V Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTP 138 ETL E + G + P G + +ALR+EL + LRPV Sbjct: 58 --SKETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALS 115 Query: 139 --SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D++I RE + Y G + E Sbjct: 116 GSSPLRPGVAEGVDLLIVRELTGGAYFG------------------------EKEEGEER 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + + +R+ R A E A R V V K N++ T ++ ++AR+ Sbjct: 152 ASDLSVYTRGEVERVARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDY-- 207 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ ++ V+ DA ++ P +DVI NL GD +SD A Sbjct: 208 ------------------PDVALEHVLVDAAAMHLVTDPGRFDVILTENLFGDILSDEAA 249 Query: 315 AQVGGIGIAPGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 G +G+ P A++G+ +FE HG+AP AG+ NP + ILSA MM RH +G E Sbjct: 250 VLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPYAAILSAAMMFRHGLGRPE 309 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 AA+ I +G+E A+ A +T D Sbjct: 310 AAEAIERGVEAAVAAGCLTPDL------GGSSGT 337 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 300 bits (768), Expect = 7e-80, Method: Composition-based stats. Identities = 88/415 (21%), Positives = 148/415 (35%), Gaps = 73/415 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I + GDGIG ++ + L V++ E+ G + + G Q G Sbjct: 1 MKRDLRFHIAVLPGDGIGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG- 57 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQG 136 E + ++ + G + P G + + LR E+DLY LRP+R Y Sbjct: 58 -TAFSDENMAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPS 116 Query: 137 TPSPV--KHPELTDMVIFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 P + K D+V+ RE +E I Y+ + + Sbjct: 117 LPRVLVDKRASQIDLVLVREQTEGILYS----------------------RCRGTIEDDR 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDR-----DSVTLVHKGNIMKFTEGAFKDWGYQL 248 S GT R+ A A + V V + N + + F+ ++ Sbjct: 155 VAWETMMISRNGTSRVSEFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEV 213 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A + D +++ P E+DV+ N G Sbjct: 214 AER--------------------HPSVSADYAYVDTTAMKLVKSPWEFDVLVTENAFGGI 253 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A VG +G+AP A+IG++ A+F+ HG+AP AGQ NP + ILS +ML + Sbjct: 254 LSDLAAGVVGSLGLAPSADIGEKHAVFQPAHGSAPHIAGQGLANPVAQILSVALMLDWLA 313 Query: 369 -------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ +E A+ ++ + AII + Sbjct: 314 DQHGEPRLAHGARILEHAVEKALT-------VVCPVEFGGKDGTAAITKAIIAQI 361 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 299 bits (766), Expect = 1e-79, Method: Composition-based stats. Identities = 101/400 (25%), Positives = 170/400 (42%), Gaps = 62/400 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++ ++V++AA ++ + + G S Q +G + Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKR---FQLDLEIGHDIAGHASLQRHG--ATVTPA 56 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ ++ + GP+ T G + + R+ELDLY +RP R + G V Sbjct: 57 LLEKVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV-- 114 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 ++ + REN+E YA E G ++ I ++ + Sbjct: 115 -GEFNLAVVRENTEGFYADRN----------------IESGSSEMLITPDTVISLRRITR 157 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+ R+A + A R V++VHK N++K +G F D Q+ARE Sbjct: 158 LCCERIARSAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVAREF----------- 205 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ + D I DA + ++ P +DVI N+ GD +SD A G +G+ Sbjct: 206 ---------PQVRVDDFIVDAMMAHVVRAPQRFDVIVTTNMFGDILSDLTAELSGSLGLG 256 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLI 376 N G + A+ +A HG+AP AG++ NP S+ILSA +L G + AA I Sbjct: 257 GSLNAGKDHAMGQAVHGSAPDIAGRNIANPYSLILSAGQLLGWHGQRKNLPAFALAARAI 316 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ A+ T D L +E G + + + Sbjct: 317 DETATAALQAREGTRD------AGGELGTAEAGQSFVRRL 350 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 102/393 (25%), Positives = 158/393 (40%), Gaps = 64/393 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +V LKV+ A + G Q G+ LP Sbjct: 2 RLAVIPGDGIGPEVVAEGLKVLRAVAP-------DVESTPYDLGASRWQRTGE--LLPDT 52 Query: 88 TLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD +R + + G + P G R L + LR ELD ++ LRP R + G SP+ P Sbjct: 53 VLDELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAP 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 DM+ RE +E Y G GV + P + + Sbjct: 113 GAIDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAF 153 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G +R+VR A E A+A R +TL+HK N++ + +++ E Sbjct: 154 GVERVVRYAFERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEF------------ 201 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 E+ + DA + P +DVI NL GD ++D AA GGIG+A Sbjct: 202 --------PEVTVAYQHVDAASMFFVTDPGRFDVIVTDNLFGDIVTDLAAAVTGGIGLAA 253 Query: 325 GANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 N+ G ++FE HG+AP AG+ +P + +LS ++L H+G + A + + Sbjct: 254 SGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSVGLLLDHLGRADQARKVNAAVA 313 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +D D ++ + GD + Sbjct: 314 ---------FDLS-TRDPEAQVRTEDVGDRLAA 336 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 110/396 (27%), Positives = 168/396 (42%), Gaps = 65/396 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 ++ I IEGDGIG +V PA + V+ A E S+ E G+ + G Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE------VGFSFTEKQAGDDTRDQTG- 53 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP T + + + G + + LR+ + ++ +RP R Y G + Sbjct: 54 -AALPETTYEAAADADATLFGAAG----ETAADVILPLREAVGSFVNIRPARAYPGVDAL 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 TD+V REN+E +Y+G E R E + Sbjct: 109 ---QPETDLVFLRENTEGVYSGHE-----------------------DRLSEDLSTLTRV 142 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +++L A Y D VHK N+M+ T+G F+D ++A Sbjct: 143 ITTSASEQLAEYACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVAA---------- 192 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ +V+ DAF ++ L P ++DV+ C NL GD +SD A VGG+ Sbjct: 193 -----------SNDVATNEVLMDAFATRVCLNPTQFDVVVCPNLAGDVLSDLAAGLVGGL 241 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ P ANIG ALFE HGTAP AG NP + ILSA M+L ++G T+AA + + Sbjct: 242 GLLPSANIGQTNALFEPVHGTAPDIAGDGIANPSASILSAGMLLEYLGETDAATNVQMAV 301 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E +N+ T D +A+IE + Sbjct: 302 ESVLNSGPRTPDL------GGNASTEAVVNAVIEQL 331 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 296 bits (759), Expect = 7e-79, Method: Composition-based stats. Identities = 89/411 (21%), Positives = 149/411 (36%), Gaps = 71/411 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + G S + L Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAG-KFNLQNHLLGGASIDKHNDP--LT 59 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-----IRSLNVALRQELDLYICLRPVR-----YYQ 135 E L+ + + G + P G + LR+EL Y LRP Sbjct: 60 DEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVD 119 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 +P + TD ++ RE + IY G + D + Sbjct: 120 SSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSG----------------------YA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 +P S R+ R A A+ N V + K N++ T ++ + +EF Sbjct: 158 CDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ ++ + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 + G IG+ P A++G ++E HG+AP +G+ VNP ILS MMLR+ Sbjct: 258 SVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRY 317 Query: 367 -MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + AD + ++ AI+ T T D S+ G+A++ + Sbjct: 318 SLNLPKEADAVEAAVKAAIDNGTKTKDL------GGNATTSDMGNAVVAEL 362 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 88/418 (21%), Positives = 149/418 (35%), Gaps = 69/418 (16%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 I + GDGIG +V +V++ + E K+ + G S +G+ Sbjct: 3 KRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDF--GGCSIDKHGEP-- 58 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQGTP 138 L A TL+ + + G + P G +ALR+ L LY +RP + + Sbjct: 59 LTAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSL 118 Query: 139 ---SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP+K D+++ RE Y G + R E Sbjct: 119 LAYSPLKPSVARGVDIIVIRELIGGAYFGERKELG-------------------ARAQED 159 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 160 AAWDTMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL-ASSRLWRKVATETIQNEF 218 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDA 312 ++ + + D+ I+ P + + VI NL GD +SD Sbjct: 219 -------------------PQLKLDHHLVDSASMLIVANPKKLNGVILTENLFGDILSDE 259 Query: 313 LAAQVGGIGIAPGANIGDEC-------------ALFEATHGTAPKYAGQDKVNPGSIILS 359 + G +G+ P A++ ++E HG+AP AGQ NP ILS Sbjct: 260 SSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIANPIGTILS 319 Query: 360 AEMMLRHMG-WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A M+ W A I +EGA + R D K + G ++E + Sbjct: 320 AAMLCGTRSVWRSPAKAIEAAVEGARRQGDR-REGLRTADLGGSSKTKDIGHKVVEIL 376 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 119/420 (28%), Positives = 190/420 (45%), Gaps = 70/420 (16%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 V+ AQG + + II GDGIG +T ++++ ++ K+ + Sbjct: 26 VMKAQGDFLNY-----QALDKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQG-KVEF 79 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQE 121 I G + + +PAE L ++E V +KGP TTP + S NVA+R+E Sbjct: 80 KVID-GLTIERRAAEHAAIPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKE 138 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDL+ +RPVR + + D +REN+E YA Sbjct: 139 LDLFANVRPVRIPE---------QGIDWTFYRENTEGAYA-------------------- 169 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +G K I E G+ + G++R++RAA EYA AN + VT V K NI+K T+G F Sbjct: 170 -VGSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDGKF 228 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQIL--LRPAEYDVI 299 D ++A++ K+I D D +++ R ++ V+ Sbjct: 229 LDIFREIAKDY--------------------KDITADDWYIDIMTAKLIDEKRRKDFQVM 268 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD I+D A GG+G A ANIG ++FEA HG+AP+ + + +P S+ Sbjct: 269 VLPNLYGDIITDEAAEFQGGVGTAGSANIGKRYSMFEAIHGSAPRMVQEGRDQYADPCSV 328 Query: 357 ILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + M+L H+G+ + AD + + ++ TVT + +EF D I+E + Sbjct: 329 IRAGAMLLAHIGYGKEADKLYQALDIC----TVTEKKLVITGRNTGATGAEFADYIMETI 384 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 291 bits (744), Expect = 4e-77, Method: Composition-based stats. Identities = 108/396 (27%), Positives = 154/396 (38%), Gaps = 64/396 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V L V+DA + + G+ L Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGS 72 Query: 88 TLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD IR A+ G + P G +R + LR ELDLY+ RP R + SP++ P Sbjct: 73 DLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDP 132 Query: 145 --ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D VI REN+E +Y+GI G + PE + + + Sbjct: 133 ARRAIDCVIVRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLST 173 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G R++ A A R SV LV K N ++ ++ + Sbjct: 174 RHGVSRVLEFAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVAR----------- 218 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 I + D ++ P +DVI N GD +SD AA GG+G+ Sbjct: 219 ---------HPHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDILSDLTAALAGGLGV 269 Query: 323 APGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 A AN+ ALFE HG+AP AG NP ILS ++ H+G E AD + + + Sbjct: 270 AASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAEHLGRNEEADAVRRAV 329 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ A VT D L E G A++ + Sbjct: 330 AAAVAAGRVTPDL------GGPLGTKEVGAAVLAEL 359 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 100/457 (21%), Positives = 167/457 (36%), Gaps = 96/457 (21%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + +Q K L + + GDGIGV++ + ++ A +S Sbjct: 16 IQAASQPSKAFFSQSALQREAIKKVTLLPGDGIGVEICSCVCELFHYANIPIQWDTYLVS 75 Query: 65 WMEIYTGEKS-----------------------------TQVYGQDVWLPA----ETLDL 91 G S + P + Sbjct: 76 GSFFGVGSDSSLNPTRNLIEEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQS 135 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMV 150 I +V +KGP T +S++ L + LY + PV+ Q P V P DMV Sbjct: 136 ILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMV 193 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 + REN+E Y+G+E + E +K + +G+ R+ Sbjct: 194 VVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRDGSMRIA 230 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 231 KWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEY------------------ 272 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I ++I D + Q++ P +D V+ NL G +S+ ++ VGG+G+ G N Sbjct: 273 --PDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNA 330 Query: 329 G-----DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 D +FE A +G+ NP +I S+ ML HMG A+ I ++ Sbjct: 331 TDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMGMNTHANRIKFALKE 390 Query: 383 AI---NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + N K +T D F +A++ ++ Sbjct: 391 TLLNANPKILTPDI------GGTGSSVSFIEAMMRHI 421 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 286 bits (733), Expect = 8e-76, Method: Composition-based stats. Identities = 86/406 (21%), Positives = 163/406 (40%), Gaps = 61/406 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG +V +KV+ ++ + ++ G + G P Sbjct: 3 TYNIALLAGDGIGPEVMKEAVKVLKLIEQR--NEDVNFELNDVLFGAAAYFAMGH--AFP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG---------IRSLNVALRQELDLYICLRPVRYYQG 136 ET + +KG + R + LR+ + + RPV +G Sbjct: 59 DETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKG 118 Query: 137 TP--SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 SP+K E D++I RE +Y G + +AD ++ ++ + E Sbjct: 119 LAHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLE---------- 168 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E+ +++V+ E ++ + + +HK N++K + + + + ++ Sbjct: 169 ---------YDEDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKN 217 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 E+ +K+++ DA + L P +DV+ N+ GD +SD Sbjct: 218 Y--------------------PEVEVKNILVDAAATYLCLNPGMFDVMVMENMFGDILSD 257 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGWT 370 +G +G+ P A G + + +E +HG+AP AG+ NP S+I S +ML G Sbjct: 258 QGGGILGSLGLMPSACKGPDKSYYEPSHGSAPDIAGKGIANPYSMIGSVALMLEMSFGLE 317 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A + M+ T D + + A L+ +EFGD + + Sbjct: 318 KEAKNLWAAMQAVFENGYSTSDLSKEGE-ANLVSTAEFGDLVCAEL 362 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 284 bits (726), Expect = 5e-75, Method: Composition-based stats. Identities = 84/415 (20%), Positives = 146/415 (35%), Gaps = 84/415 (20%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GD IG ++ LK++ E+ + +IS+ G S G + E Sbjct: 6 KLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISY--GLIGGASLDKTG--SAITDE 61 Query: 88 TLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGT---P 138 L+ + G + P + LRQ LD + +RP R+Y + Sbjct: 62 VLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQ 121 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP+K D V+ REN Y G + + + Sbjct: 122 SPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDE-------------------------- 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDS---------VTLVHKGNIMKFTEGAFKDWGYQ 247 + +R R + A R V K N++ + ++ + Sbjct: 156 -----ARTEVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL-ASGRFWRTVTHD 209 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNG 306 + EF +I + D +AD+ ++ P +++ VI N G Sbjct: 210 IFEREF-------------------PDIELHDQLADSMAMVMVKAPTKFNGVIHTDNTFG 250 Query: 307 DYISDALAAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPGSIILS 359 D +SD VG +G+ P A++ ++EA HG+AP +G + NP + ILS Sbjct: 251 DILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSAPDISGTGQANPIAQILS 310 Query: 360 AEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 M+LR+ ADL+ + + + R D + GDA+ Sbjct: 311 LAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 283 bits (724), Expect = 7e-75, Method: Composition-based stats. Identities = 89/415 (21%), Positives = 153/415 (36%), Gaps = 68/415 (16%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + K K + + + I G+G+G ++ A+ +V+ A Sbjct: 62 QDKQKSKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKA------- 114 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W + E L +R +V IKGP+ + R +R++ Sbjct: 115 PIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQ 163 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 + + + +G SP D+VI R+ E Y+GIE + Sbjct: 164 FAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVVPGVMQT------- 213 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 IK + G R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 214 ----------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 257 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 + A + +++ ++ D + +ILL+P + DV+ Sbjct: 258 LEAMRAEADKHVD-------------------DVLFEERYLDTCILKILLKPHKCDVMVS 298 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 ++ GD + +G GI PG ++ +F+ AG+D NP +LSA Sbjct: 299 SSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAA 358 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MLRH+ + AD + + D R D KCSEF A+ + + Sbjct: 359 LMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 85/346 (24%), Positives = 145/346 (41%), Gaps = 55/346 (15%) Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQE 121 + E++ + + + IR RVA+KG + T +S N LR Sbjct: 1 DFEEVHVSSNADEE------DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTS 54 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDLY + + G V + D++I REN+E Y+ +E ++ + E Sbjct: 55 LDLYANVIHWKSLPGV---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-------- 103 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +K ++ + R+ A + A + R VT VHK NIMK +G F Sbjct: 104 ---------------SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLF 148 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 ++A +I +++I D Q++ RP ++DV+ Sbjct: 149 LQCCREVAARY--------------------PQITFENMIVDNTTMQLVSRPQQFDVMVM 188 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSA 360 NL G+ +++ A VGG G+ GAN G A+FE AT T A ++ NP + +L++ Sbjct: 189 PNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLAS 248 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCS 406 MML H+ A I K + +++ + V + + + CS Sbjct: 249 CMMLDHLKLHSYATSIRKAVLASMDNENVRFPSHPTLLPRPVSPCS 294 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 280 bits (716), Expect = 7e-74, Method: Composition-based stats. Identities = 91/387 (23%), Positives = 152/387 (39%), Gaps = 48/387 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ P + +V + +++ + G + + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDP-------SVNFTFYNISSERYINKG--ITIKDSE 54 Query: 89 LDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 +D ++ Y G + G + + + LR+ELDLY+ +RP + Sbjct: 55 IDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----N 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 M I REN ED Y+ I + + + + S + Sbjct: 110 NIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKN 169 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 KR A + A D ++VT+ K N + +++ + Sbjct: 170 LKRFFNMAYKIA---DTETVTITDKANAVDMYS-LWREIAIE------------------ 207 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + I AD+ ++ P +Y I NL GD +SD +A VGG+G AP Sbjct: 208 ---ESEPAGKKINFEYADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPS 264 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 NIGD ++FE HG+AP AG++ NP + ILS MML+H+ TE A ++ K +E I Sbjct: 265 GNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVENVIR 324 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAI 412 T+ ++ EF + + Sbjct: 325 NGTI------PIESGGNAGTHEFINKV 345 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 280 bits (715), Expect = 9e-74, Method: Composition-based stats. Identities = 102/422 (24%), Positives = 165/422 (39%), Gaps = 78/422 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++T A ++ E +I W + + +G V P E Sbjct: 16 RITLLPGDGIGPEITDACRGLIADVFPHWELTETQIGWSQ-------WRAHGNPV--PQE 66 Query: 88 TLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVR 132 T + + A+ +T+ G RS + LRQ LDL+ +RPV Sbjct: 67 TWETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV- 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAG------IEWKADSADAEKVIKFLREEMGVK 186 G + D I REN+E +Y+ + ADS + + + + Sbjct: 126 TLPGAAA--------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVAR 177 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND--------RDSVTLVHKGNIMKFTE 238 + + ++ + RL R A + A+A +VT+ K NI++ + Sbjct: 178 AVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSA 237 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 + ++A E ++ ADA Q++ PA +DV Sbjct: 238 RVIRGAVEEVAEEY--------------------PQVAFDFANADAVAMQLVTDPARFDV 277 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIIL 358 I NL GD +SD A +GG+G+A AN+GD A+FE HG+AP AG+ NP + +L Sbjct: 278 IIAENLIGDILSDIGAGLIGGLGLAASANVGDNFAVFEPVHGSAPDIAGRGIANPAAFLL 337 Query: 359 SAEMMLRHMGWT----EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 SA M H+G A + + + A +D SEF A+ Sbjct: 338 SAAMCAEHLGAPVSELAPAAKLREAVYAATRT-------APTLDLGGTATTSEFVAAVRA 390 Query: 415 NM 416 + Sbjct: 391 EL 392 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 75/388 (19%), Positives = 150/388 (38%), Gaps = 58/388 (14%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG ++ ++K+V + + KI+ + Y G S + + + Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCI----YTGYKINIIYNYIGGISIDKFNTP--ITNNLIS 59 Query: 91 LIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 +I+ G + + LR++ + + +RP++ P K Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---N 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I RE + IY G + P K +E+ Sbjct: 111 IDIIIVRELNGGIYYGKPKGFSKQII---------------NQIPTWYAYNTKIYNEQEI 155 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 RL R + A+ N + + + K N+++ T +K + + Sbjct: 156 IRLARISFNLAL-NRKKKLCSIDKSNVLE-TFKLWKKTINYVHKFY-------------- 199 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ + + D ++ ++DVI NL GD ISD + G +G+ P Sbjct: 200 ------NKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGMLPSI 253 Query: 327 NIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAI 384 +I ++ +LFE HG+AP A ++ NP +LS MM + + + ++ + + + Sbjct: 254 SINNKSLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYVLNDFKLSNNLYYSIYKVL 313 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAI 412 + T D ++ + K++ EFGD + Sbjct: 314 SYGFCTIDMKKYIRNFKIVSTEEFGDLV 341 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 276 bits (706), Expect = 1e-72, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 143/278 (51%), Gaps = 34/278 (12%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDG G ++ A +V++A W G + G LP Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E Sbjct: 54 SVLESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF---EN 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + + ++ +L ++ E GI IKP S G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRP--NALIKEPGGISIKPMSVPGS 168 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEY-------------- 214 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 +I D I D Q++ +P YDV+ NL Sbjct: 215 ------PDIEFDDRIVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 93/399 (23%), Positives = 156/399 (39%), Gaps = 65/399 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + G GIG ++ L+V+ AA +S+ K Sbjct: 32 SKYGGKTNVTILTGSGIGPEIMDHTLRVLKAA-------GAPLSYEIFALSSKDGSKNND 84 Query: 81 DVWLPAETLDLIREYRVAIKGPLT-TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 E L IR RVA+KG + I+S N+ R+ LDL++ + + + G Sbjct: 85 F----DEALTSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLS- 139 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+ + R+N+E Y +E + + E +K Sbjct: 140 --NKFGEIDITVIRQNTEGEYLMLEHEPRTGSVE-----------------------SLK 174 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + +RL+ A +YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 175 VLTRFNLERLIEFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSY------- 227 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 I + + + + +I P +DVI NLNG IS+ L +GG Sbjct: 228 -------------PMIKMNVLDVNVAIFKIASNPRIFDVILATNLNGSMISNYLNGMLGG 274 Query: 320 IGIAPGANIG-DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G+ G N D A+FE G ++ NP ++I+S +L H+G+ + A++I Sbjct: 275 PGLTSGINFSADGIAVFEPGARNKGSSIVGLNRANPIAMIMSGINLLHHLGYNKTAEMIH 334 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + YD R D E D II ++ Sbjct: 335 NSVYATL-----VYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 268 bits (685), Expect = 3e-70, Method: Composition-based stats. Identities = 85/396 (21%), Positives = 150/396 (37%), Gaps = 61/396 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I G+GIG +V A LK++ + + + G + + G + P Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAK---IQGFTLQVDYGWLGATAFEQLG--SYFP 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGT----PSPV 141 T +L + G ++ + + LR+ D + LRP+R Sbjct: 63 QATTELCDGADGIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRP 115 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + D++I RE IY G ++ + G Sbjct: 116 EKIQGLDILIVRELVSGIYFGPSGRSSDE--------------------RGNYGYHTMRY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +E +R+ R A+E A R +T+ HK N + + + A + Sbjct: 156 YDEEIRRIARKALEQAQYR-RGLLTVAHKENALPHLH--WTRLVQEEATKF--------- 203 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++++ ++ D Q++L P +DVI NL GD +SD A VG IG Sbjct: 204 -----------PNVIVEPMLVDNLAMQMVLNPQRFDVILASNLFGDILSDIGGALVGSIG 252 Query: 322 IAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 + A++ L+EA HGTAP AG NP + + +ML+ G +AA I+ Sbjct: 253 LLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLGACVLMLQQWGEVQAAQQIIAAQ 312 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + L+ + D ++E + Sbjct: 313 DRILAKGYRTADLFTQGEEI-LVNTATLVDLLLEEL 347 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 268 bits (684), Expect = 4e-70, Method: Composition-based stats. Identities = 95/407 (23%), Positives = 157/407 (38%), Gaps = 67/407 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDGIGVDV A + V++ A++ + GE + EI G + G D + Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLD--IEDG 57 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + G + P G S ++ LR LY +RPV+ Y P + Sbjct: 58 GEERAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLAD 117 Query: 144 PE--LTDMVIFRENSED-IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+VI RE++E Y+ K + + + Sbjct: 118 PRAAGIDLVILRESTEGLFYSAAAHKRS-------------------LVVNDDEVQDVLR 158 Query: 201 CSEEGTKRLVRAAIEYAIAND----RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + + T +L R A A +T V K N+ + F+ ++ E Sbjct: 159 ITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSEFA--- 214 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + DA ++ +P E+DV+ N+ GD +SD Sbjct: 215 -----------------DVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGDILSDLAGGL 257 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT------ 370 VGG+G+A IGD LF+ HG+AP G+DK NP + ILSA +ML ++ Sbjct: 258 VGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYLAEKLDKPSL 317 Query: 371 -EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA+LI +E + R ++ + ++ + Sbjct: 318 ADAAELIDSAVETGFWHNAL-----RPIEFGGDMGTRAVTKELLGRV 359 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 103/423 (24%), Positives = 169/423 (39%), Gaps = 79/423 (18%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 P + L ++ + + GDGIG + L+V ++ K+ + Sbjct: 34 QAPGRKDFKKL--------DHITVGILPGDGIGPCIMEQALRVAKYLLKDEMASG-KVEF 84 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQE 121 I G + ++ LPAE L+ + V +KGP TP + S N LR+ Sbjct: 85 RTIP-GMTIEERVQKNESLPAEVLEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRA 143 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RPVR + + D FREN E Y Sbjct: 144 LQLYAAVRPVRIPE---------KGIDWTFFRENIEGEYI-------------------- 174 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 G K I+ + + K + G +R+ RAA E+A N + +VT+V K NI+K +G F Sbjct: 175 -WGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNF 233 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR--PAEYDVI 299 + L +E I +++ + D+ +I + V Sbjct: 234 LKTAHALEKEY--------------------PGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD ++D A GG+G A +NIGD+ ALFEA HG ++ +P S+ Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQYALFEAIHGVGNFLVQHNRAQYADPCSL 333 Query: 357 ILSAEMMLRHMGWTEAADLIVKGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 I + M+ H+G+ E + +VK ++ +T D + EF D ++ Sbjct: 334 IRAMGEMISHIGYPEKKEQLVKALDICTRTERKVVITTDKD-------GATAEEFTDYLL 386 Query: 414 ENM 416 + + Sbjct: 387 DTL 389 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 266 bits (680), Expect = 1e-69, Method: Composition-based stats. Identities = 100/411 (24%), Positives = 156/411 (37%), Gaps = 86/411 (20%) Query: 42 TPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAI 99 LKV+ A E I W ++ G + G W P++ + + Sbjct: 1 MREGLKVLHAVSEP-----LGIEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLIL 54 Query: 100 KGPLTTPVGGGIR-------------SLNVALRQELDLYICLRPVRYYQGTPSPVK---- 142 G + P G S + R L+LY +RP++ Y G + Sbjct: 55 LGAVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHK 114 Query: 143 ---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 DMVI REN+E +YA K I + Sbjct: 115 QIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKA-------------------DVAIDTR 155 Query: 200 PCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 156 VITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEY 214 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 EI I DAF Q ++ +P YDV N+ GD ++D Sbjct: 215 --------------------PEIEKDTAIVDAFTQWLVGQPEYYDVCVTSNMFGDIVTDL 254 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + GG+G+A G NIG A+FE HG+APK+AG+DKVNP ++ILS + L + + Sbjct: 255 ASTLQGGMGMAVGGNIGKHNAMFEPIHGSAPKHAGKDKVNPIAMILSVKEGLEWLAARKD 314 Query: 373 ADLIVK-------GMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + K + + T+TYD + + KCSE G AI E Sbjct: 315 DATLTKAAEAIEAAVVEVLEKGETLTYDL---VGNDRASKCSEVGSAIAEA 362 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 263 bits (672), Expect = 9e-69, Method: Composition-based stats. Identities = 75/423 (17%), Positives = 145/423 (34%), Gaps = 90/423 (21%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 ++ + P+ + ++GD IG +V +L + D K+ E G Sbjct: 3 RSSGKDAPKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSH---FGIKVETFERLIGGSCLD 59 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRP 130 + + TL E + G + P + + +R+ L+LY +RP Sbjct: 60 QHDCP--IQESTLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRP 117 Query: 131 VRYYQGTP---SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 + S +K +++ REN+ IY G + + D Sbjct: 118 AKIISERQLELSSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH------------- 164 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 +AA+ A ++ + V K N+M T ++ Sbjct: 165 -------------------------KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVV 198 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNL 304 + R+EF + + + D+ + P + + V+ NL Sbjct: 199 TETIRDEFPQLMD-----------------KLSHQLVDSAAMLLAKDPRKLNGVVLTENL 241 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDEC----------ALFEATHGTAPKYAGQDKVNPG 354 GD +SD + G +G+ A I +++ G+AP AG+ NP Sbjct: 242 FGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIANPI 301 Query: 355 SIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + +S +M R +G +AAD I ++ + + T D L + G A+ Sbjct: 302 GMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV------GGTLSTQQAGSALR 355 Query: 414 ENM 416 +++ Sbjct: 356 QSI 358 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 93/363 (25%), Positives = 153/363 (42%), Gaps = 52/363 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG ++ P + + + I+++ + G + + + Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS--------DINFVTFDISSERYIKTG--IIIKDDE 53 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 L+ ++ YR + G + P G + + + LR+EL+LY+ +RPVR + + Sbjct: 54 LEELKNYRAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------D 104 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 + I REN++D Y I + V E G G+ Sbjct: 105 KIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGML-------- 156 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R ++ A + +VT+ K N +K ++ + A E Sbjct: 157 SYRYLKKFFNKAFSICDSTVTVTDKANAVKMYN-LWRSTAMEAAIE-------------- 201 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 K I I ADA ++L P +Y I NL GD ISD AA VGG+G AP Sbjct: 202 -------KNINISFEYADALAYNMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPS 254 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIGD+ ALFE HG+AP AG+D NP + I++ M+L ++G+ + + +I + Sbjct: 255 ANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYLGYRDESRIINDMVRNLYI 314 Query: 386 AKT 388 Sbjct: 315 NGV 317 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 100/377 (26%), Positives = 161/377 (42%), Gaps = 66/377 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +++G G+G D ++ ++ AA + + + G + + +G+D LP Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAA-------KVPVEFEVHLAGRMALE-HGKD-ALPKA 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICLRPVRYYQGT 137 T D IRE +A+K L P G G + NVA R++L L+ +RPV G Sbjct: 54 TFDAIRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGI 113 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 PS D ++FRE +ED+Y E + + Sbjct: 114 PSRFT---GVDFLLFREITEDLYTASEHEIVPGVVQ-----------------------S 147 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 K +E R + A + A R +V +HK NI+K +G F + Y++A+E Sbjct: 148 FKIVTEAACLRFFKLAFDTARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEY----- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 EI KD+I D Q++ RP +++V+A NL GD +SD A V Sbjct: 203 ---------------PEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGAGLV 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+ N G+ ++EA +G + + D NP +IL A +L+ +G T A I Sbjct: 248 GGVSTTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETGTAGRIQ 307 Query: 378 KGMEGAINAK-TVTYDF 393 K +E + T D Sbjct: 308 KAVETVLLEGRIRTRDI 324 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 100/407 (24%), Positives = 162/407 (39%), Gaps = 109/407 (26%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V PA ++++A K + +++ G ++ + G L Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEAL---PSYLGLKFEFTDLHAGFETFERTG--AAL 58 Query: 85 PAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P +T++++R E A+ G +++P G S VALR++LDLY +RPV+ + Sbjct: 59 PDKTVEILRNECDGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTV------L 112 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + DMVI REN+ED+Y E D+ D + IK Sbjct: 113 SAAKPIDMVIVRENTEDLYVKEETTRDTPDGK--------------------VAEAIKRI 152 Query: 202 SEEGTKRLVRAAIEYAIANDR------------DSVTLVHKGNIMKFTEGAFKDWGYQLA 249 SE + R+ A + A+ + VT+ HK N++ Sbjct: 153 SERASHRIATMAGDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL--------------- 197 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 + +K+VI D NL GD + Sbjct: 198 -------------------------LRLKNVIVD------------------PNLYGDIL 214 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD AA VG +G+ P AN+G+ A+ E HG+AP GQ+ NP + + SA +ML + Sbjct: 215 SDDAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIMGQNIANPIATLRSAALMLEFLDE 274 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I ++ + + D K +E + I+ + Sbjct: 275 EAAAAKIYAAVDANLTEGKL-----LSPDLGGTAKTTEVIEDILRRL 316 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 257 bits (656), Expect = 6e-67, Method: Composition-based stats. Identities = 113/404 (27%), Positives = 198/404 (49%), Gaps = 39/404 (9%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + + VP+ I YI+GDGIG ++T AM+ VV++A+E AY+G R I W +I G Sbjct: 10 YIEFTDSGMVVPDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGT 69 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + +G ++P +++ I++ +A+K L R LN LR+ L LY +R ++ Sbjct: 70 EAYEKFG--TYVPEDSIKEIQKMYIAMKSTL--NFMPDKRDLNTILRKRLGLYSNIRILK 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 Y +G PV ++ I R+++ + + + S + +I+F+ + G + Sbjct: 126 YIEGMDIPVNTFNRLNLTIIRDSTPNSHI---FYHSSESTDDLIRFISDNYG---LNITP 179 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 GI + P S+ T+++ + A+ Y+ N + +T++ F +W + A Sbjct: 180 DSGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEA--- 231 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + +++ + + F+++++ P +++VI N+ + D Sbjct: 232 -----------------SAQEDVGYEVLKTREFMKRLISSPEDFEVILVDNVLSQTLVDY 274 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 LA G I I G++IGDECA+FEA + P AG D +P S ILS ML H+GW EA Sbjct: 275 LA---GTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEA 331 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + A + D D +KCSEF II+ M Sbjct: 332 AQIIENAISAAFRDNKIPKDINTRPDI-SPIKCSEFSSEIIKRM 374 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 256 bits (654), Expect = 1e-66, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 164/402 (40%), Gaps = 73/402 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + A L V ++K +R + ++ I G + Q+ LP Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQR-VEFVPIK-GMTIEERARQNKSLPPA 96 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ + + +KGP TP + S N LR++L LY +RP+R + Sbjct: 97 VLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE-------- 148 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 + D FREN E Y G K I + I K S+ Sbjct: 149 -KGIDWTFFRENIEGEYI---------------------WGNKGICVGDDLAIDFKILSK 186 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +RL R A EYA ++ + ++T+ K NI+K +G F + + +E Sbjct: 187 PGAERLFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEY----------- 235 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPA---EYDVIACMNLNGDYISDALAAQVGGI 320 I +++ + D+ +++ P V NL GD ++D A GG+ Sbjct: 236 ---------PGIHVREELIDSLSAKLM-DPEFNAGMQVFVLPNLYGDILTDIAAEYQGGL 285 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLIV 377 G A +NIGD+ A+FEA HG ++ +P S+I + M+ +G+ E D + Sbjct: 286 GTASSSNIGDQYAMFEAIHGVGVYLVEHNRAQYADPSSLIRAMGEMMAFIGYPEKRDRLF 345 Query: 378 KGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ +T D + EF + ++E + Sbjct: 346 KALDFCTKVERKAVITTDKD-------GATAEEFAEYVVETL 380 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 102/355 (28%), Positives = 160/355 (45%), Gaps = 38/355 (10%) Query: 47 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 106 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGE-----DQQGLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 107 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSGK---RIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 VH+ + M T+G F + +A+E +I D + Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQEF--------------------PDIAFADRSIEVIC 222 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 Q+++ +P +DV+ NL GD ++ A VGG+ + P A++GD+ A+F T Sbjct: 223 QELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVF-GAQSTGTDDV 280 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 G D P S+IL+ +MLRH+G EAA + +E + + T + Sbjct: 281 GHD---PTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVDTTADLNPVGFEG 332 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 96/429 (22%), Positives = 163/429 (37%), Gaps = 98/429 (22%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG +V A ++A + E+ + +PA+ Sbjct: 10 VAVMPGDGIGPEVMAATRHALEAL------PGPALVLTELGWPAHAWHR-DHGEMMPADW 62 Query: 89 LDLIREYRVAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 + Y + G L P G + + LR+ LDL+ C RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 138 PSPVKHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ P TD+++ RENSE Y ++ G P Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTPRETA 163 Query: 196 IGIKPCSEEGTKRLVRAAIEYA----------IANDR---------DSVTLVHKGNIMKF 236 ++ + GT+R++R A E A + R +V +V K N +++ Sbjct: 164 TQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQY 223 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 + + ++A E I + DA + + +P ++ Sbjct: 224 AGELWSEVFAEVAAEY--------------------PGIATHHELIDACCMKFVSQPWQF 263 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE----CALFEATHGTAPKYAGQDKVN 352 DV+ NL+GD ++D A GG+G+AP AN+ LFE THG+AP AG D+ + Sbjct: 264 DVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGADRAH 323 Query: 353 PGSIILSAEMMLRHMGWTE-----AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 P +++L+A ML MG + +A + + + I G C+E Sbjct: 324 PAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE-----------HGMGGRGCAE 372 Query: 408 FGDAIIENM 416 G A+ + + Sbjct: 373 VGRAVAQRI 381 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 248 bits (634), Expect = 3e-64, Method: Composition-based stats. Identities = 83/368 (22%), Positives = 138/368 (37%), Gaps = 61/368 (16%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +DA E + I W + E L +R +V IKGP+ + Sbjct: 1 MDAVQEVICAVKAPIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS--- 52 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 53 ---RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVV 106 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + G R+ YA+ N R +T+ Sbjct: 107 PGVMQT-----------------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVA 143 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +++ ++ D + + Sbjct: 144 HKANIMRMTDGNFLEAMRAEADKHVD-------------------DVLFEERYLDTCILK 184 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 ILL+P + DV+ ++ GD + +G GI PG ++ +F+ AG+ Sbjct: 185 ILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGK 244 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408 D NP +LSA +MLRH+ + AD + + D R D KCSEF Sbjct: 245 DLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGGKAKCSEF 299 Query: 409 GDAIIENM 416 A+ + + Sbjct: 300 VKAVCDCL 307 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 245 bits (625), Expect = 3e-63, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 145/420 (34%), Gaps = 68/420 (16%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 ++L+NG I I GDG+G ++T + + A E R + E G Sbjct: 3 DIVSLRNGS----RIYTIALIPGDGVGPEITREAVLTLKRAGE---VYGRSFQFTEAIAG 55 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR------SLNVALRQELDLY 125 + LP E+L E + G L G++ S+ LR L L Sbjct: 56 TAALDR--GQCPLPRESLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLR 113 Query: 126 ICLRPVRYYQGTP--SPVK---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +RP + + P+K + D++I R+ + ++ Sbjct: 114 SDIRPCFFAEALRELCPLKEEIRKKGMDILIIRDIAGGMFT------------------- 154 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 G + E + R A + A + R VT + K I+ + Sbjct: 155 -TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQLAASRKRK-VTSLDKA-ILLSSSVL 211 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 ++ + R+ EI ++ ++ D +++ P +DVI Sbjct: 212 WRQILEETHRDY--------------------PEIELEHMLVDHGAFKLVSSPDAFDVIV 251 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEA--THGTAPKYAGQDKVNPGSII 357 N+ GD I+D A G P ++ + ++ H + AG + NP +I Sbjct: 252 ASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPVGMI 311 Query: 358 LSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L+A MML + G A+ + + + + G + + G+A+ E + Sbjct: 312 LAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGRP--CWSGGEQTADTAAIGEAVRECL 369 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 244 bits (622), Expect = 5e-63, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 134/346 (38%), Gaps = 55/346 (15%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +++ V+ + I W + + + + + L+ + ++ IKGP + Sbjct: 2 IESLVKVFSTVQVPIDWDVFH---EHKINSAEGEDVSPKLLESLCRNKIGIKGPFESGPC 58 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 59 ------LRKLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + EG R+ R EYA N+R +T+ Sbjct: 110 PGVMQT-----------------------IKVSTAEGADRMARYVFEYAKKNNRKKITVA 146 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +I+ ++ D Sbjct: 147 HKANIMRLTDGTFLSPMRREAAKY-------------------QDDIMFEERYLDTVCLA 187 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 +L++P DV+ ++ GD ++ A+ +GG + PG +G ++E T AG+ Sbjct: 188 MLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPGFAVGPMGLIYEPIIHTNTNIAGK 247 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA-KTVTYDF 393 D VNP ++LS +MLR M E AD I + T D Sbjct: 248 DIVNPTGMLLSGVLMLREMKLNEYADKICCAVSTVFRETDCRTKDL 293 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 243 bits (620), Expect = 9e-63, Method: Composition-based stats. Identities = 157/219 (71%), Positives = 183/219 (83%), Gaps = 1/219 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + LNVP NPIIP+IEGDGIG+D++P M+KVVDAAV+KAY GE Sbjct: 3 YQKIQVPATGDKITVNADTSLNVPNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISWME+Y GEK+TQVY QD WLP ETLD +++Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+CLRPVR+++G PSPVK P DM IFRENSEDIYAGIEWKA S +A KVIKFL+ Sbjct: 123 QLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLK 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 219 EEMGV KIRF + CGIG+KP S+EGTKRL R A+ A A Sbjct: 183 EEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 84/406 (20%), Positives = 150/406 (36%), Gaps = 56/406 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + E ++ + G+G+G +V L ++ E G+R G ++ + Sbjct: 18 RGTGTERGEAFLVGVLPGEGVGPEVIDVALSLLRLLGEA--TGQRFEVRTGGPIGRQAER 75 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + G+ L E D + L P GG LR+ DLY L P+R++ Sbjct: 76 LTGRG--LTPEVRDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPA 130 Query: 137 T-PSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + V PE D++I REN+ +Y G EW ++ A + Sbjct: 131 LADAGVLRPEAARSADVLIVRENASGLYCG-EWGSEGEGAAR------------------ 171 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R++R A+ A R + +V K + + D +A E Sbjct: 172 -SAYQVCRYRADEVERILRTALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGE- 228 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + + + D Q++ P ++DVI C N+ GD + D Sbjct: 229 -------------------HGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGDC 269 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 + +G G++ N G A+++ HG A AG+D+ NP + S MMLR Sbjct: 270 GSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLRESFRLP 329 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + + T D + + G A+ ++ Sbjct: 330 ALADALETAIARTLARGVRTADIQGA--QPTAVGTRAMGQALCASL 373 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 240 bits (612), Expect = 9e-62, Method: Composition-based stats. Identities = 93/397 (23%), Positives = 151/397 (38%), Gaps = 71/397 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGI +++ A+ V DA +I ++ + ++S + G ++ Sbjct: 7 NRYSIVELHGDGIARELSQAVHTVADALP-------FEIEFIPVDLSDESREAKGDAIY- 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E +R Y ++K P T S N LR+ + + RPV G + + Sbjct: 59 -DEAEAAMRRYGTSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQT--HYN 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E + I R + Y R + I+ Sbjct: 112 ERIHLDIVRIATGGTY-----------------------EDAGRRINRDTAVSIRAIERR 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 + R A A D +V K I K T+G F++ +AR+ Sbjct: 149 PSVLASRFAFRLAQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDY------------ 195 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + DA L I++RP Y VI C N GD++SD +G IG+ Sbjct: 196 --------PATEFREELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGLIGSIGLGD 247 Query: 325 GANIGDE------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 A+ + A+F+ GTAP AGQ+K NP + +L+ MLRH+G +++ + Sbjct: 248 SASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAMANMLRHIGEHDSSKALRG 307 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + GAI A T D L SEF I++ Sbjct: 308 ALFGAIEAGEKTADI------GGSLNLSEFTQVIVDR 338 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 234 bits (597), Expect = 4e-60, Method: Composition-based stats. Identities = 80/415 (19%), Positives = 143/415 (34%), Gaps = 79/415 (19%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 NGK P + IEG G G V A+ K+ AA+ + W Sbjct: 34 NGKAQRP--IRVTVIEGQGTGPVVLAAVRKIFKAAL-------VPVEWDYQTLSVYRDHK 84 Query: 78 YGQDVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + P LD E + + ++P + S ++AL + L+ ++ +R G Sbjct: 85 TNRMTVNPQ-LLDSAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG 143 Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + ++V RE+ Y+ IE + Sbjct: 144 ----HEPYGPINLVNIREHVSGEYSEIEHLVSPGVVQ----------------------- 176 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 IK S++ + + + A +YA + +T++HK ++M+ ++G F +++ Sbjct: 177 SIKTVSKKISVEVAKLAFDYACKHGHSRITVLHKADVMRLSDGIFLKACREVSACY---- 232 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + D+F + P Y+V+ +L G + Sbjct: 233 ----------------PDVEYNEEKLDSFCLNVTTNPGRYEVLLTTSLYGAFAGSVCGMM 276 Query: 317 VGGIGIAPGANIGDECALFEA---------THGTAPKYAGQ------DKVNPGSIILSAE 361 GG+ P G + +F +H + +NP II +A Sbjct: 277 SGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYGQEQIINPTGIIRAAA 336 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +ML H G A I +E I T D CS+F DAII+N+ Sbjct: 337 LMLDHAGMVVAGRCIAAAVEDTIRQGIRTQDM------GGDASCSQFTDAIIKNL 385 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 87/416 (20%), Positives = 142/416 (34%), Gaps = 78/416 (18%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I DG+G DV P K + A E E + E G + G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE--AGVEYAVKTGK--MC 57 Query: 85 PAETLDLIREYRVAIKGPLTT----------PVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I + + G P + LR + I LRP+R Sbjct: 58 EDNLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLR 117 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 +G P+++ E D+++ R+ +E Y E Sbjct: 118 KGIDCPLRNREEIDVLLVRQLAEGFYIRPGH-----------------------MIGEDA 154 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHK-GNIMKFTEGAFKDWGYQ 247 + T++ A + VTL +K GN+ F ++ + Sbjct: 155 AYDTIVVTRNVTEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCF--DFYRKIFTE 212 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 ++ +I ++ DA + ++ P +DVIAC N+ GD Sbjct: 213 VSAGY--------------------PDIGLQFTQVDALAEHLIKDPDRFDVIACENMIGD 252 Query: 308 YISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 I D A GG+GI P A++G F HGT P+ G+ NP + IL+A ++L + Sbjct: 253 IIGDIGAYITGGMGITPTADVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTL 312 Query: 368 G-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G A LI K +E + T R D +A+ + M Sbjct: 313 GNERGDDNLRRGARLIEKAVEYNL-----TTGGPRTKDLGGTANTFATAEAVFKAM 363 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 82/435 (18%), Positives = 150/435 (34%), Gaps = 74/435 (17%) Query: 25 ENPIIP--YIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + +E DG M +++ EK I G + Sbjct: 42 KRIKVAKPVVEMDG------DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV- 131 V + ++ ++Y VA+K TP + +S N +R L + P+ Sbjct: 96 VTI--DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 153 Query: 132 -----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 R G P + I R D Y ++ AD A K++ ++ GVK Sbjct: 154 CKNIPRLVPGWTKP--------ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVK 205 Query: 187 KIRFPEHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 + G+ ++E + +YAI + + + K I+K +G FKD Sbjct: 206 EWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKD 264 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ + + + W + + D + Q+L + V AC N Sbjct: 265 IFQEIFDKHYKTDFDKNKIW-------------YEHRLIDDMVAQVLKSSGGF-VWACKN 310 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNPGS 355 +GD SD LA G +G+ + + EA HGT ++ + + NP + Sbjct: 311 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 370 Query: 356 IILSAEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL----- 403 I + L H G + A ++ K + + +T D + G + Sbjct: 371 SIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEH 430 Query: 404 --KCSEFGDAIIENM 416 ++F D I N+ Sbjct: 431 FLNTTDFLDTIKSNL 445 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 224 bits (572), Expect = 4e-57, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 129/362 (35%), Gaps = 73/362 (20%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V A +A E ++W V + Sbjct: 16 YKIAAIRGDGIGPEVIEAGNY--QSAEETNRVAWILLNWPSRTLSGA--------VRITR 65 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 T D+ P+++ S + LR + P R + G SP+ Sbjct: 66 NTADI---------SPISSSTFLWFSSY-LPLRSS---TSNM-PTRVFHGIQSPLH---- 107 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D VI RENSE YAG G P I + G Sbjct: 108 LDWVIVRENSEGEYAGHG-------------------GRSYAGKPWEVATDISIFTRHGV 148 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+++ A E A + + +T+ K N + + ++A E + Sbjct: 149 ERIMKFAFEAARSRAKKHITVATKSNAQRNGLVVWD----EIAAAEVAAQF--------- 195 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ ++ DA +++L P D I NL+ +SD +A G IGIAP + Sbjct: 196 ------PDVTCDKMLVDAMTARVVLTPESLDTIVPTNLHAGILSDLASALAGSIGIAPTS 249 Query: 327 NIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N+ ++FE HG+A AG+D + ML +G AA +++ +E Sbjct: 250 NLDPTRENPSMFEPVHGSAFDIAGKDLA----TFWTVAEMLSWLGQKGAAAELLECVESV 305 Query: 384 IN 385 Sbjct: 306 CK 307 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 77/404 (19%), Positives = 131/404 (32%), Gaps = 90/404 (22%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + E G S +V+ + Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAK 61 Query: 86 AETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQGT--- 137 A + + G + P G + LR+EL Y LRP + + Sbjct: 62 ALAAAKAADAILL--GAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVD 119 Query: 138 PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K TD ++ RE + IY G + D + Sbjct: 120 SSPLKADVCRGTDFIVVRELTGGIYFGARTEDDGSG----------------------FA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + S +R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 158 MDTDAYSRAEIERIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ + + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLEVGHQLIDSAAMLMVKSPRALNGVVVTSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 + G IG VNP ILS MMLR+ + + Sbjct: 258 SVIPGSIG--------------------------AGIVNPIGTILSVAMMLRYSLNLPKE 291 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + A++ T T D + DA++ + Sbjct: 292 AAAVEAAVRTALDNGTRTKDL------GGSAGTFQMADAVVVEL 329 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 93/388 (23%), Positives = 149/388 (38%), Gaps = 52/388 (13%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +G+GIG ++ ++ V+ A++ GE ++ + G ++ G+ V P E Sbjct: 8 RLGVWQGEGIGPEIVAPTVQAVELALQA--SGEATPEFVPLLLGREAINATGRIV--PEE 63 Query: 88 TLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 T + I I GP P G + + LR++ DL+ +RPVR G P Sbjct: 64 TWETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP--- 120 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI REN+E +YA S D + + + Sbjct: 121 --DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAI--- 175 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 A +T+ HK N++ T G + A E Sbjct: 176 --------------AAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF----------- 210 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + ++ V DA +++ RP Y I N+ GD +SD G +GIA Sbjct: 211 ----------GVEVQPVHIDALCAELVTRPERYATIVAENMFGDILSDLAGGLGGSLGIA 260 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N + + +A HG+AP AGQ NP I+ SA ML +G+ +AA+L+ + A Sbjct: 261 GSINASESQVMAQAAHGSAPDIAGQGIANPAGIMNSAAQMLDSLGYPQAAELLEGAVREA 320 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDA 411 + K T D R A + D Sbjct: 321 VV-KAPTADLVREAAAADPETATPVADE 347 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 218 bits (554), Expect = 4e-55, Method: Composition-based stats. Identities = 79/433 (18%), Positives = 145/433 (33%), Gaps = 64/433 (14%) Query: 19 GKLNVPENPII--PYIEGDGIGVDVTPAMLKVVDA-AVEKAYKGERKISWMEIYTGEKST 75 K++ + + P +E DG M +V+ A EK I M + Sbjct: 174 NKMSGFQRIKVDQPVVEMDG------DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHR 227 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYI 126 V + + I+ + V +K TP ++ S N +R LD I Sbjct: 228 DKTDDQVTI--DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTI 285 Query: 127 CLRPV--RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184 P+ + P ++I R D Y +++ D + ++ Sbjct: 286 FRAPILMKNVPRLVPSWTKP----IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSN 341 Query: 185 VKKIRFPE--HCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 + E G+ + ++ K + +YA+ + L K ++K +G F Sbjct: 342 PEVHEVYEFKGGGVALGMYNTDASIKGFAHSCFQYALDQKM-PLYLSTKNTVLKKYDGRF 400 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 KD + +E+ + + G W + + D + Q + + V AC Sbjct: 401 KDIFQTIYEKEYKQKFEEAGLW-------------YEHRLIDDMVAQAIKSSGGF-VWAC 446 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNP 353 N +GD SD +A G +G+ + + EA HGT ++ Q + NP Sbjct: 447 KNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTSTNP 506 Query: 354 GSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK-- 404 + I + L H E + + + A +T D + G KL Sbjct: 507 IASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRD 566 Query: 405 ---CSEFGDAIIE 414 +F D + Sbjct: 567 YLCTEDFMDKLAR 579 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 82/434 (18%), Positives = 145/434 (33%), Gaps = 76/434 (17%) Query: 28 IIPY----IEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 I +E DG M +V+ + +K ++ G V Sbjct: 5 KITVQNPIVEMDG------DEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKV 58 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV-- 131 + E+ + ++Y VAIK TP + RS N +R L+ + P+ Sbjct: 59 TV--ESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMC 116 Query: 132 ----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR---EEMG 184 R G P + I R D Y + A K++ E+ Sbjct: 117 KNIPRLVPGWTKP--------ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTE 168 Query: 185 VKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 + F G+ + + + + R A++ A + + L K I+K +G FKD Sbjct: 169 FEVYNFTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKD 227 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ + + + G W + + D + L Y V AC N Sbjct: 228 IFQEVYEANWKSKYEEAGIW-------------YEHRLIDDMVAYALKSEGGY-VWACKN 273 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYA------GQDKVNPGS 355 +GD SD LA G +G+ + + EA HGT ++ G+ N + Sbjct: 274 YDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIA 333 Query: 356 IILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK---- 404 I + L H + + + GA+ + +T D ++ L Sbjct: 334 SIFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHY 393 Query: 405 --CSEFGDAIIENM 416 EF DA+ + + Sbjct: 394 LNTEEFIDAVADEL 407 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 214 bits (546), Expect = 4e-54, Method: Composition-based stats. Identities = 66/411 (16%), Positives = 139/411 (33%), Gaps = 58/411 (14%) Query: 43 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV--TKDAAEAIKKHNVGVKC 73 Query: 102 PLTTPVGGGI---------RSLNVALRQELDLYICL--RPVRYYQGTPSPVKHPELTDMV 150 TP + +S N +R L + + S P ++ Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP----II 129 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI---RFPEHCGIGIKPCSE-EGT 206 I R D Y ++ ++ + F E G+ + ++ + Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 + ++ + A++ + L K I+K +G FKD ++ +++ + W Sbjct: 190 EDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW--- 245 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + + D + Q + + + AC N +GD SD++A G +G+ Sbjct: 246 ----------YEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLGMMTSV 294 Query: 327 NIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGWTE------- 371 + + EA HGT ++ + NP + I + L H + Sbjct: 295 LVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAF 354 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLL------KCSEFGDAIIENM 416 A+ + + I A +T D + G + EF D + EN+ Sbjct: 355 FANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENL 405 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 211 bits (537), Expect = 5e-53, Method: Composition-based stats. Identities = 81/408 (19%), Positives = 141/408 (34%), Gaps = 78/408 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P I + GD G ++ L+V+ +V + + +++ ++ + V Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIRQ-----PLQFLDYDLSLENRRATDNKVV-- 57 Query: 86 AETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQ------GTP 138 E R+ +++K TP G + S N LR+ L+ + LR R G Sbjct: 58 WEAAQAARDSGLSLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVY 117 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 SP + I R +D Y EW+ + + Sbjct: 118 SP--------IAIVRMAVDDAYGSKEWRETTE-------------------NGDEIAYRT 150 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S + + +YA + V K + EG FK+ A+ Sbjct: 151 SKISRSTCRAVAEFTFQYA-KRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRY------ 203 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 E+ + ++ DA +L E VI +N +GD +SD + G Sbjct: 204 --------------PEVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDMVLQMYG 249 Query: 319 GIGIAPGANIGDECA-------LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT- 370 I + +G E + EA HGTAP G++ NP ++IL+ +L + Sbjct: 250 SIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLSYGRIPQ 309 Query: 371 --EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +A+ I + + I T D + SEF D +I + Sbjct: 310 AEKASRAIYESVFETIYEGKATPDL------GGQMTTSEFTDEVIRRV 351 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 211 bits (536), Expect = 6e-53, Method: Composition-based stats. Identities = 85/408 (20%), Positives = 140/408 (34%), Gaps = 68/408 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +PE I +EGD G ++ ++V+D + ++ + V Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGV 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ +R IK TP G + S N LR+E+D + +R R G Sbjct: 56 V--SDAAAAMRTCGFGIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIA 113 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + I R ED Y +W+ A A + + Sbjct: 114 GVHYP--ISIVRMAIEDAYGAKQWREGDAGAA------------------DEVAYRTEHV 153 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + + A A A + V K + EG K+ A Sbjct: 154 TRSTCRAVSEYAFRTARAM-QARVYGGPKWTVSPVYEGMLKEEMDAAAAR---------- 202 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILL-RPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + V+ DA ++ E V+ +N +GD +SD + G I Sbjct: 203 ----------HPDVAYEPVLIDATYAGLVSGAADEPLVVPALNRDGDCLSDLVLPMFGSI 252 Query: 321 GIAPGA------NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM------G 368 A N A+ EA HGTAP G+D NP +++L++ +LRH G Sbjct: 253 AGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVANPMAMLLASGAVLRHAAERGHPG 312 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ I + + AI T D +EF DA+IE + Sbjct: 313 AERASRAIYESVLEAIATGIKTPDL------GGHAGTTEFTDAVIERI 354 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 63/383 (16%), Positives = 128/383 (33%), Gaps = 62/383 (16%) Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQE 121 G + V + E + I++Y V +K TP + S N +R Sbjct: 101 GIEYRDQTDDKVTV--EAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNI 158 Query: 122 LDLYICLRPV------RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKV 175 L + P+ R G P ++I R D Y + ++ Sbjct: 159 LGGTVFREPIVIPAIPRLVPGWTKP--------IIIGRHAFGDQYRATDRVIPGPGKLEL 210 Query: 176 IKFLREEMG--VKKIRFPEHCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGN 232 + V+ F G+ + +++ + ++ + A+ + + K Sbjct: 211 VYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNT 269 Query: 233 IMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR 292 I+K +G FKD ++ E+ E G W + + D + Q++ Sbjct: 270 ILKRYDGRFKDIFQEIYEAEYKKEFDAKGIW-------------YEHRLIDDMVAQMIKS 316 Query: 293 PAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK 350 + ++A N +GD SD +A G +G+ + + F EA HGT ++ + + Sbjct: 317 EGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQ 375 Query: 351 ------VNPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAI-NAKTVTYDFERL 396 NP + I + L G + A+ + + + +T D Sbjct: 376 KGRETSTNPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALS 435 Query: 397 MDGAKL---LKCSEFGDAIIENM 416 + + E+ A+ + Sbjct: 436 CGRKEREAWVTTREYMAAVERRL 458 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 204 bits (519), Expect = 4e-51, Method: Composition-based stats. Identities = 72/403 (17%), Positives = 130/403 (32%), Gaps = 74/403 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDG+G +V +++ E+ G ++ G LPA Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVE----VTGPWPVGARAAAETGD--VLPA 55 Query: 87 ETLDLIREYRVAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTPSP 140 TL + G + P G R LR+ DL I +R Sbjct: 56 GTLAACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVR----------E 105 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + + ++ + R Y G + + D + + Sbjct: 106 IPFADGRELTVVRNLIGGSYGGADDRVLREDGSE--------------------AADVLR 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + E +V A + + V K N + T ++ +ARE Sbjct: 146 LTRERVAEVVHTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARE--------- 195 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 + I ++ D ++ DV+ L GD +SD A + G Sbjct: 196 ------------RGIEVEHRYVDRAAFELGSGAPVPDVLVTEGLLGDILSDLAAGRAGSP 243 Query: 321 GIAPGANIGDE-------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 + A++ LFE HG+AP+ A +D+V+P L+ +LRH T A Sbjct: 244 ALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPLGGFLALAALLRHFPATREA 303 Query: 374 -DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + + + + TYD +G + DA++ Sbjct: 304 GERVRAAVGAVLRSGPWTYDLV--PEGGAAASTGQVADAVLAA 344 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 69/395 (17%), Positives = 128/395 (32%), Gaps = 68/395 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G + + + +D K+S + G L Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDF---GGVALAAGAGTAL 64 Query: 85 PAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG--TPSPV 141 P+ TL R+ + P G + LRQEL+ + +RPVR+ Sbjct: 65 PSTTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 142 KHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 PE+ D+ FR+ + +Y G +A + Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAG----------------------DDGEAYDT 162 Query: 199 KPCSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 P S + +R+ R A YA+ + V + K N+M T ++ + EF Sbjct: 163 TPYSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF---- 217 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 ++ ++ V+ D + P + +I N+ GD +SD Sbjct: 218 ---------------PQVPLRHVLVDTASMILSSDPLSLNGIILTENMFGDILSDQAGGI 262 Query: 317 VGGIGIAPGANIGD--------ECALFEATH-GTAPKYAGQDKVNPGSIILSAEMMLR-H 366 +G + A + +FE + K G P I + +ML Sbjct: 263 LGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNPGGKTVG-----PLGSIQAVGLMLELS 317 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 +G ++ + K + ++ + R +D Sbjct: 318 LGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 80/395 (20%), Positives = 133/395 (33%), Gaps = 103/395 (26%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I +VT A+ +V+DA Y E Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQAPVYF-------------ETYIIKGKNMN 40 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 L E +D IR+ +V + G + + GG R+ELDL+ L G PS Sbjct: 41 HLTWEVVDSIRKNKVCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS--- 90 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+V+ REN+E YAG E + E + Sbjct: 91 RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT----------------------MT 128 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + R+ + A EYA + R VT VH G K + F + ++A+ Sbjct: 129 KFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMY--------- 179 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + + + R + + I++ + GG Sbjct: 180 -----------PNITYNE--IASRETRAIRRHSNSKSLWA------IIANIASGVAGG-- 218 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + GD+ A+FE + NP +++ S+ MMLRH+ AD + + Sbjct: 219 -----SFGDDYAIFEQVGSVG------NHKNPVALLFSSVMMLRHLLLPLFADRLKTAVT 267 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I+ G E D++I N+ Sbjct: 268 RVISEGKC---------GNSNTTTQEVVDSVIANL 293 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 58/182 (31%), Positives = 82/182 (45%), Gaps = 25/182 (13%) Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 + ++G F +A++ EI ++ D ++ P Sbjct: 112 RMSDGLFLRCVRDMAQKF--------------------PEIQFEEKYLDTVCLNMVQNPG 151 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 +YDV+ NL GD +SD A VGG+G+ P N+G ALFE+ HGTAP AG+D NP Sbjct: 152 KYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPT 211 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +++LSA MMLRHM AD I + I D KCSEF + I Sbjct: 212 ALLLSAVMMLRHMELNTYADKIERAAFETIKEGK-----YLTGDLGGRAKCSEFTNEICA 266 Query: 415 NM 416 + Sbjct: 267 KL 268 Score = 57.0 bits (136), Expect = 1e-06, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 21/57 (36%), Gaps = 7/57 (12%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 T + + I GDGIG +++ A+ K+ AA I W + Sbjct: 35 ATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDV 84 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 191 bits (486), Expect = 4e-47, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 111/303 (36%), Gaps = 62/303 (20%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 +N P I I GDGIG ++ + ++V+ AA + + ++ + G + + G Sbjct: 1 MNAPHALDIAVIPGDGIGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTG- 55 Query: 81 DVWLPAETLDLIR-EYRVAIKGPLTTP-----VGGGIRSLNVALRQELDLYICLRPVRYY 134 + A TL+ IR Y +KGP+ P G L LR LD Y +RP+ Sbjct: 56 -SAMSAATLERIRTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALL 114 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G +P++ D VI REN+E +Y + Sbjct: 115 PGVDAPLRG-TAVDYVIVRENTEGLYLSRGRGVG----------------------NDRA 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 + G +R+V A E A VT V K N+++ + F++ ++ Sbjct: 152 CADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEV 210 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A ++ ADA ++ P +DV+ N GD Sbjct: 211 ATRY--------------------PQVEADHRYADAAGHDLVADPGRFDVLVMENFLGDI 250 Query: 309 ISD 311 +SD Sbjct: 251 LSD 253 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 190 bits (482), Expect = 1e-46, Method: Composition-based stats. Identities = 77/431 (17%), Positives = 140/431 (32%), Gaps = 88/431 (20%) Query: 25 ENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + P +E DG M +V+ +K + G + Sbjct: 79 DRVKVQNPIVEMDG------DEMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDK 132 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV- 131 V + E+ + +Y VA+K TP + RS N +R L+ + P+ Sbjct: 133 VTV--ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPIL 190 Query: 132 -----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 R G P + I R D Y + K+I + Sbjct: 191 CLNIPRIVPGWKKP--------ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPL 242 Query: 187 KIRFPE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 ++ + G+ + + + + R +++ A A + + L K I+K +G FKD Sbjct: 243 ELDVYDFKGPGVALAMYNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKD 301 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ E++ + + W + + D + + Y V AC N Sbjct: 302 IFQEVYEEKWKQKFEEHSIW-------------YEHRLIDDMVAYAVKSEGGY-VWACKN 347 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA------GQDKVNPGSII 357 +GD SD + EA HGT ++ + N + I Sbjct: 348 YDGDLSSD------------------GKTLEAEAAHGTVTRHFRLFQKGQETSTNSIASI 389 Query: 358 LSAEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKL-----LKC 405 + L H G + + + A +T D L+ G K+ L Sbjct: 390 FAWTRGLEHRAKLDKNEGLLDFVHKLEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNT 449 Query: 406 SEFGDAIIENM 416 EF DA+ +N+ Sbjct: 450 EEFIDAVAQNL 460 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 187 bits (474), Expect = 9e-46, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 179/404 (44%), Gaps = 52/404 (12%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I L L +P++ I YIEGDG G ++T AM+ V++A+E AY G + I W +IY G Sbjct: 2 YIKLDGNHLIIPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGR 61 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + YG+ +LP E+++ IR+ +KGPL++ + G +N+ +++ L+LY ++ + Sbjct: 62 EAYEKYGK--YLPRESIEDIRKTVFVMKGPLSSNING--HDININIKRILNLYTDVKCIT 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G E ++ IF + +++Y + DS D++ + ++L++ + Sbjct: 118 GLPGLS------EGKEIFIFSPSIDEVY---HFSYDSEDSDMLRQYLQQSFNIS---IGG 165 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 I +K S R+++ A + A + L ++ Sbjct: 166 DSDIFLKGTSRY---RIIKIASKIAEISS-------------------LYGIKRTLVADD 203 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + G + + EI + D + + +++ + I Sbjct: 204 YTGSHAPLWVYNTLNKMEMPVEIENLYNLYDEMTSE-----SRFNIFIPDSRLSSLIIKI 258 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + A+ GA +GD +LFE+ + G D +P S +L++ MMLR + + +A Sbjct: 259 INART-----FFGAILGDFISLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDA 313 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ + + + + LKCS+F DAI++ M Sbjct: 314 ALILRNALNSVYSDGILPASL----NLNNGLKCSDFIDAIVKRM 353 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 184 bits (467), Expect = 5e-45, Method: Composition-based stats. Identities = 68/415 (16%), Positives = 141/415 (33%), Gaps = 53/415 (12%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ ++ + G V + ++ Sbjct: 41 PLVEMDG------DEMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQVTV--DS 92 Query: 89 LDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPVRYYQGTPS 139 + + VA+K TP + +S N +R LD + P+ +G Sbjct: 93 AEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRGID- 150 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK--IRFPEHCGIG 197 P + + + R D+Y E + +++ + ++ F E + Sbjct: 151 PCVKNWVRPITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVVE 210 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + RA ++A+A +D V K I K + FKD ++ ++ Sbjct: 211 GMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAARF 269 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 G I + D + +++ + + AC N +GD +SD +++ Sbjct: 270 EAAG-------------IEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAF 315 Query: 318 GGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKV------NPGSIILSAEMMLRHMGWT 370 G + + +EA HGT ++ + N + I + LR Sbjct: 316 GSLAMMTSVLASPHGYWEYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAEL 375 Query: 371 E-------AADLIVKGMEGAINAKTVTYDFERL--MDGAKLLKCSEFGDAIIENM 416 + AD + + I + +T D R+ ++ L F A+ E++ Sbjct: 376 DGLADLAAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDL 430 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 177 bits (450), Expect = 5e-43, Method: Composition-based stats. Identities = 71/418 (16%), Positives = 130/418 (31%), Gaps = 95/418 (22%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ +K I G + V L + Sbjct: 15 PVVELDG------DEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTL--DA 66 Query: 89 LDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPS 139 + I++Y V +K TP + S N +R L + P+ P Sbjct: 67 AEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPAIPR 125 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR--EEMGVKKIRFPEHCGIG 197 V + ++I R D Y + D+ +++ + + +K FP G+ Sbjct: 126 LVPSWKQ-PIIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKGGKPEVIKVYDFPAEGGVA 184 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 FKD ++ ++ E Sbjct: 185 QT----------------------------------------QFKDIFQEIYEAQYRKEF 204 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 G W + + D + Q++ Y +IA N +GD SD +A Sbjct: 205 EAAGIW-------------YEHRLIDDMVAQMIKSEGGY-IIAMKNYDGDVQSDIVAQGF 250 Query: 318 GGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGW 369 G +G+ I + F EA HGT ++ + + NP + I + L G Sbjct: 251 GSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQKGRETSTNPIASIYAWTQGLIKRGE 310 Query: 370 TE-------AADLIVKGMEGAI-NAKTVTYDFE---RLMDGAKLLKCSEFGDAIIENM 416 + A+ + K + +T D D + + +E+ DA+ + Sbjct: 311 LDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQGKKDRSAWVTTNEYLDAVERRL 368 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 173 bits (438), Expect = 1e-41, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 122/416 (29%), Gaps = 61/416 (14%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 97 G ++T ++ ++ A + W E K+ V + ++ + + Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTA--WREFDLRAKNRDDTEDQVL--RDVIEAGKAVKA 73 Query: 98 AIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 K P TP ++ S N A+R+ + R + G K P + Sbjct: 74 IFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE 133 Query: 149 MVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 R YA G + + + + + Sbjct: 134 ----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNP 189 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 + L R + +V K + K+ E + ++ EE+ + +D G Sbjct: 190 YDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFW-QIMKKVFDEEYKSKFVDAGV 247 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 + +++DA +++ +A N +GD ++D LA G Sbjct: 248 MKSGD--------ELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGF 299 Query: 323 APGANIG--DECAL---FEATHGTAPKY------AGQDKVNPGSII--LSAEMMLRHMGW 369 +G + L FEA+HGT + +NP ++ L M H Sbjct: 300 ITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAM--NHAAD 357 Query: 370 TE---------AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D L +F DA+ E + Sbjct: 358 VHNVDKERTLAFTAKMRAVIHQLFREGKGTRDLSGPS----GLTTEQFVDAVAERL 409 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 172 bits (435), Expect = 3e-41, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 122/337 (36%), Gaps = 55/337 (16%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRF---P 161 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDYCS---------- 248 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I ++ + D + +++ PA +D I + +++ + GG + Sbjct: 249 ---------IKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSA 299 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 +GD A+F+ T ++P I+ + +L H+G A + KGM + Sbjct: 300 IELGDSHAVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQESCAKSLWKGMLRTMT 358 Query: 386 AKTVTYDFERL-------MDGAKLLKCSEFGDAIIEN 415 T +F+ + L+CS G+ + + Sbjct: 359 DGIKTVEFDGPDTGEYVICNIMNKLRCSALGENVEKK 395 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 169 bits (429), Expect = 2e-40, Method: Composition-based stats. Identities = 52/129 (40%), Positives = 69/129 (53%), Gaps = 6/129 (4%) Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAG 347 ++ P+++DV+ NL GD +SD A +GG+G+ P NIG A+FE+ HGTAP AG Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAG 89 Query: 348 QDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 +D NP +++LSA MMLRHMG A I I K V D KCSE Sbjct: 90 KDMANPTALLLSAVMMLRHMGLHGHAKKIETACFDTIRDKKV-----LTKDLGGNPKCSE 144 Query: 408 FGDAIIENM 416 F I + Sbjct: 145 FTADICRRV 153 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 169 bits (427), Expect = 2e-40, Method: Composition-based stats. Identities = 58/426 (13%), Positives = 123/426 (28%), Gaps = 72/426 (16%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKIS-WMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 G ++T +++ + + + IS W K+ + + ++ + Sbjct: 89 GEEMTHYATQLL---LNQWIEPYFDISSWETFDLSCKARDDSDDATLI--DAVEAGKRIG 143 Query: 97 VAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 K P TP ++ S N A+R+ + R + +G K+ L Sbjct: 144 AIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQVLF 203 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC----GIGIKPCSE 203 + R Y G W ++ + + + Sbjct: 204 E----RHAVGGEY-GAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPY 258 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + + L + + + +V K + K+ EG + ++ + + E + G Sbjct: 259 DNVRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFW-ATMKRVFDDTYKDEFLKAGLL 316 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + + +I+DA Q++ +A N +GD ++D +A G Sbjct: 317 DRSGG-------ELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFI 369 Query: 324 PGANIG---DECAL---FEATHGTAPKYAGQDKV------NPGSII--LSAEM------- 362 +G D L FEA+HGT NP ++ L M Sbjct: 370 TSNLVGVSDDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLE 429 Query: 363 ------------MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGD 410 M ++ + + + T D +F Sbjct: 430 YDAKPNDVEAKRMYEYV--NNFTNTLRMALHNTFRYGQGTRDMCGP----TGFTTEDFIA 483 Query: 411 AIIENM 416 + + Sbjct: 484 KVAWRL 489 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 167 bits (422), Expect = 1e-39, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 121/332 (36%), Gaps = 54/332 (16%) Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + + R A+ + V + ++ L +LDLY+ VR + G Sbjct: 97 TDDFYNSVLRNRSAV--HVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRF--- 151 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 ++ I +N+ +Y+ +E+ E I ++E Sbjct: 152 PDVNIRIIAQNNMGVYSDLEYSPVKGVVE-----------------------AISVSTQE 188 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G ++ +R A A+ +R VTL+HK T+GA ++ ++ Sbjct: 189 GNEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHC--------- 239 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++ + + + +++ P E+D I + I+ + GG + Sbjct: 240 ----------LELELMNVEDCIGRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFS 289 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 IGD A+F+ ++P I+ + + H+G+TE D + + M + Sbjct: 290 AVEIGDFHAVFKPLQ-VKLSLTNYPILSPYGIVNTIVDLFDHLGYTECGDALWEQMLRTM 348 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T DF D + + C+ II + Sbjct: 349 ESGIKTKDFGGE-DSGEYVICN-----IINRL 374 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 157 bits (398), Expect = 5e-37, Method: Composition-based stats. Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 13/185 (7%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + + A +L P+ + G G+G +++ A+ + +AA + Sbjct: 8 YASSAIRATASPRSLSTSASTSPQ-FTVTLFPGHGVGPEISVAVQNIFNAA-------DV 59 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W E + + A+ LD +R R +KGP+ TP+G G RSLN+ LR+ Sbjct: 60 PIVWDEHHIDVD--NAKPGQDLISADALDSLRRNRFGLKGPMATPIGKGYRSLNLTLRKA 117 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RP G +P + D+V REN+E Y+G+E E + E Sbjct: 118 LGLYANVRPCVSIPGVQTPY---DDVDVVTVRENTEGEYSGLEHVVYPGVVESLKVITPE 174 Query: 182 EMGVK 186 + + Sbjct: 175 RVNAR 179 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 157 bits (397), Expect = 7e-37, Method: Composition-based stats. Identities = 77/462 (16%), Positives = 131/462 (28%), Gaps = 129/462 (27%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ +K + G + V + E+ Sbjct: 66 PIVEMDG------DEMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVTV--ES 117 Query: 89 LDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV------RY 133 + +Y VA+K TP + RS N +R L+ + P+ R Sbjct: 118 AEATLKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCXNVPRI 177 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE- 192 G P + I R D Y + + K++ ++ + Sbjct: 178 VPGWKKP--------ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDF 229 Query: 193 -HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 GI + + + + R +++ A A + + L K I+K +G Sbjct: 230 KGPGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG----------- 277 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + + D + L Y V AC N +GD S Sbjct: 278 -------------------------RYEHRLIDDMVAYALKSDGGY-VWACKNYDGDVQS 311 Query: 311 DALAA---------------------------------QVG----GIGIAPGANIGDECA 333 D LA G I I+ D Sbjct: 312 DLLAQGFLLHMRNERSDYPVXLHLVKSYPILFVLSRIRFFGSYDFSIAISGKQLSSDGKT 371 Query: 334 L-FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMG-------WTEAADLIVKG 379 L EA HGT ++ Q + N + I + L H + + Sbjct: 372 LEAEAAHGTVTRHFRQYQKGLETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVHKLEAA 431 Query: 380 MEGAINAKTVTYDFERLMDGAKL-----LKCSEFGDAIIENM 416 + + +T D L+ G K L EF D + N+ Sbjct: 432 CIETVESGNMTKDLAILIHGPKASXEFYLNTEEFIDTVAHNL 473 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 95/321 (29%), Gaps = 63/321 (19%) Query: 104 TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGI 163 P + LR+E+ Y +RP + + + P+ G+ Sbjct: 36 GAPATSRPERGLLKLRKEMGTYGSMRPCFFASDS---LVAPQG--------------RGV 78 Query: 164 EWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRD 223 A ++L + + + +P S +R A Sbjct: 79 PRHRLCHCARAHRRYL-----LWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDK 133 Query: 224 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIAD 283 + + N++ T ++ + +EF ++ ++ + + Sbjct: 134 KLWSLDNANVL-ATSRFWRKVMTETFEKEF-------------------PDLKVEHQLIN 173 Query: 284 AFLQQILLRPAEYD-VIACMNLNGDYISDALAAQVGGIGIAPGANIG-------DECALF 335 + + ++ P + V+ L GD ISDA IG+ P A++ ++ Sbjct: 174 SAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPDSIGLLPSASLSGIPDGNRKSNDIY 233 Query: 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFER 395 E H + + + S W +D + ++ V R Sbjct: 234 EPIH--VLPLVSRARASSTPSARSC-------PWPCFSDTL----STSLRRLWVPPWSLR 280 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 + E G+A+I + Sbjct: 281 TKELGGGANTKELGEAVINEV 301 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats. Identities = 63/407 (15%), Positives = 127/407 (31%), Gaps = 79/407 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + G+G G ++T +V+ + + + IY S + Sbjct: 3 SIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADAVT 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRS-----LNVALRQELDLYICLRPVRYYQGTPSP 140 ETL YR K ++ V R+ +R++L ++ T SP Sbjct: 63 EETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQA------IKVEHFTLSP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +++ R+ ++ Y+G S DA Sbjct: 117 TSS-----ILLVRDQAQGFYSGTNSVNTSKDAVSR----------------------TAH 149 Query: 201 CSEEGTKRLVRAAIEYAIAN--DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S+ R++ A+ A +SVT+V+K +G F W + Sbjct: 150 FSKAIFARILSYALGRANQLWGGTNSVTMVYK---FHLFDGLFHTWATE----------- 195 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 V + + +D++A + ++++ N D + L + G Sbjct: 196 -WERTFGVNIRFVQGDTMNRDLLAFGV--------SGHNLLISGNEYADIMQTILLDRFG 246 Query: 319 GIGIAPGANIGDEC--------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGW 369 +G A + + ++ HG+A G+ VNP + I +A +L G Sbjct: 247 -LGAQESACAENVYLHPDVQGLSEYQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQAGC 305 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D F +A ++ + Sbjct: 306 SGLKQRVDCVLGDLGARGIGTPDQ------GGTATTERFVEAFLQGL 346 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 145 bits (366), Expect = 2e-33, Method: Composition-based stats. Identities = 53/203 (26%), Positives = 91/203 (44%), Gaps = 33/203 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +++ +++K+ DAA + + + G + G+ +P Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAA-------KVPVEFETENAGSDVYEKTGE--LIPES 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + Sbjct: 54 LYESVERNKIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNI 110 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+ IFREN+E IY G E + I +K +++G++ Sbjct: 111 DLAIFRENTEGIYIGEEKYENEEKT---------------------SAIAVKRITKKGSE 149 Query: 208 RLVRAAIEYAIANDRDSVTLVHK 230 L++ + + + L K Sbjct: 150 ELLKVLLNMQRIMEFRKLQLFIK 172 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 143 bits (361), Expect = 9e-33, Method: Composition-based stats. Identities = 63/395 (15%), Positives = 115/395 (29%), Gaps = 47/395 (11%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I G G G ++ VV + + ++ S Sbjct: 5 DPLRIGVAIGHGTGPELATVFEHVVRELASR---YSLGVEFVRSDRIYHSYNSLPLADES 61 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSPV 141 T D+ E I R L V R + LY +R + + Sbjct: 62 QNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYA-VR--QQLEAVKVEC 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + +++ R+ ++ Y G D+ + R+ + I F Sbjct: 119 FDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHFRKGVFQHIIAFSLERAREKWGY 178 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 G SV LV+K +G W +EFG ++ Sbjct: 179 DLGGI----------------KSVFLVYK---FHLFDGLLLSWARD-WTKEFGIKVEFIQ 218 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 P +N + +IA I+ I N + + + Sbjct: 219 PDTMNRN-LIAFGVHRCLMIAGNEYADIMQ------TIFLEKFNMRVQETSCSE---NVY 268 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + P N + ++ THG+A G+ VNP + I +A +L G I ++ Sbjct: 269 LKPVLN---RLSEYQTTHGSADDITGKGIVNPSATIRAAAAILERFG---GCVGIDAKVD 322 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +N + + D L + F D + + Sbjct: 323 DTLN--ILQKNKSGTPDQGGNLTTAAFVDVFLRTL 355 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 136 bits (343), Expect = 1e-30, Method: Composition-based stats. Identities = 65/404 (16%), Positives = 133/404 (32%), Gaps = 64/404 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI-----SWMEIYTGEKSTQVYG 79 + + G G G ++ +V+ K Y + ++ +T S + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLA-KQYSVNFEFVRSSSTYHSYHTLTVSGEDKN 62 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ET +Y+ + + + R+ A LY+ +R ++ Q Sbjct: 63 LITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHA----QSLYL-VR--QHLQAAKV 115 Query: 140 PVKHPELTD-MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + +++ R+ ++ YAG + + Sbjct: 116 EHFSLGDGNALLMVRDEAQGFYAGDNTYS----------------------ADQLSITRT 153 Query: 199 KPCSEEGTKRLVRAAIEYAIAN-----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S+ R++R A++ A N VT+ +K +G F+ W Q + +F Sbjct: 154 TSFSKPVFDRIIRFALDRAAENWGPENVPKKVTMAYK---FHLFDGVFQAWEPQ-WKAQF 209 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 G + P + + + +I +++P +N G S Sbjct: 210 GIDFDFIQPD-TLNRSLMANGVQGRCIIIAGNEYADVIQP------VFLNWFGQ--STPE 260 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEA 372 + + P N + ++ HG+A A + VNP + I +A +L RH G Sbjct: 261 TMYAENVYLRPDVN---GLSEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGI 317 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L + ++ + K T D LK E D ++ + Sbjct: 318 QKLTEQAIQSLLQRKLTTPDQ------GGSLKTEETVDHFLQAI 355 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 135 bits (339), Expect = 4e-30, Method: Composition-based stats. Identities = 67/409 (16%), Positives = 119/409 (29%), Gaps = 78/409 (19%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I G DG V A ++ + K I++ ++ ++ P Sbjct: 225 TVIAGYDG----VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANP---PERA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L P R L ++L Y PVR Sbjct: 278 L-------------WGVPDNTTGRK-LYKLVKQLKRYGI--PVRNAH------------- 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A + ++K + + + R + I + E Sbjct: 309 VSISRMSAGGGDQY---GSFNMPAQEDGILKVVVDGVEKHARRVSQGDPILLMSNDHEAI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V A ++ V K M++ + F + RE + Sbjct: 366 KDWVSQVFRDA-SSKHKEVYFGLKREYMEY-DEVFSTVINDVRRELAADHTSPPAFMIMR 423 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + L +++ P + NL+GD SD AA G + A Sbjct: 424 PSSQ---------------LIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSI 468 Query: 327 NIGDECAL-FEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHMGWTE------ 371 + FEA HGTA + NP ++I + L +G E Sbjct: 469 IESKSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALL 528 Query: 372 -AADLIVKGMEGAINAKTVTYDF---ERLMDGAKLLKCSEFGDAIIENM 416 + + ++ + VT D + L+ F D+I + + Sbjct: 529 DYSARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRL 577 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 120 bits (301), Expect = 1e-25, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 51/138 (36%), Gaps = 11/138 (7%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 20 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 76 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 77 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 134 Query: 118 LRQELDLYICLRPVRYYQ 135 LR L ++ LRP Sbjct: 135 LRSGLKVFANLRPASVLP 152 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 119 bits (297), Expect = 3e-25, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 79/225 (35%), Gaps = 30/225 (13%) Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E + S++G + +R A + A R VTL++K ++G+ + +L Sbjct: 13 EGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCH 72 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 ++ + + +++ P +D + ++S Sbjct: 73 YKDCLELELMEVEE-------------------AISRLMTEPTYFDCLFASERYATFLSA 113 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG + IGD A+F+ T ++ I+ + + +H+G + Sbjct: 114 ICSGVCGGANLFSAVEIGDHHAVFKPLQ-TKLSLTNYANLSAYGIVSTIVDLFQHLGHDK 172 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + ++ +N T + + G+ +I N+ Sbjct: 173 CADALWCELKRTMNEGIRTK------EFGG----QDTGEYVICNI 207 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 114 bits (285), Expect = 6e-24, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 8/122 (6%) Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSII 357 N+ GD +SD A G I +AP +I E +LFE HG+ P G+ NP + Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 358 L---SAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 M+L H+G+ E I +E +++ D K + G AI Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPL--TPDLGGSAKTDDLGKAIAA 118 Query: 415 NM 416 + Sbjct: 119 AI 120 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 114 bits (284), Expect = 1e-23, Method: Composition-based stats. Identities = 62/412 (15%), Positives = 120/412 (29%), Gaps = 84/412 (20%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + G DG V A ++ + + + + + ++ ++ P Sbjct: 225 TVVPGYDG----VMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNP---PQRA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L + + +K L Q+L Y G P + Sbjct: 278 LWGVPDNVSGMK--------------LYKLVQQLKHY----------GLP-----ERKAN 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A +IK + + + I E Sbjct: 309 VSISRMSAGGGDQYGSYNTPAPEDG---IIKVIMDGEEKHARTVKSNDPILFMSNDRESI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V+ A + + + L RE + + L++ Sbjct: 366 KDWVKQVFRDAALYKK--------------------EVYFGLKREFVNYDEVYSSIILEI 405 Query: 267 KNPNTGKEIVIKDVIADAFLQQ---ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + + + +Q ++ P + + NL+GD SD AA G + A Sbjct: 406 RKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATA 465 Query: 324 PGANIGDECA-LFEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHM------- 367 + LFEA HGTA + N ++I + L + Sbjct: 466 SSVIKSKDGTLLFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNA 525 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERL---MDGAKLLKCSEFGDAIIENM 416 E A+ + + + T+T D + + ++ F DAI N+ Sbjct: 526 PLAEYAEALKAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESNL 577 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 76/210 (36%), Gaps = 23/210 (10%) Query: 112 RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169 RS N +R L+ + P + S K P + I R D Y + + Sbjct: 32 RSPNGTIRNILNGTVFREPILCKNVPRILSGWKKP----ICIGRHAFGDQYRATDTIING 87 Query: 170 ADAEKVIKFLR-EEMGVKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTL 227 K++ E + + G+ + + + + R +++ A++ + + L Sbjct: 88 PGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLYL 146 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 K I+K +G FKD ++ E++ + + W + + D + Sbjct: 147 STKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIW-------------YEHRLIDDMVA 193 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQV 317 + Y V AC N +GD SD LA Sbjct: 194 YAVKSEGGY-VWACKNYDGDVQSDFLAQIF 222 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 102 bits (255), Expect = 2e-20, Method: Composition-based stats. Identities = 29/139 (20%), Positives = 49/139 (35%), Gaps = 17/139 (12%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + ++ + + ++ ST Sbjct: 45 AKYGGRHTVTLIPGDGIGPELLNHVRELFR-------FSCVPVDFEVVHVNSSSTSEDDI 97 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV--GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 + IR VA+KG + T +S N LR LDLY + + G Sbjct: 98 S-----NAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQ 152 Query: 139 SPVKHPELTDMVIFRENSE 157 + + D++I E SE Sbjct: 153 T---RHKNIDIIIILEKSE 168 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 99.8 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 26/129 (20%) Query: 117 ALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI 176 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 1 MLHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE--- 54 Query: 177 KFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 236 +K ++ + R+ A + A V VHK NI K Sbjct: 55 --------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKL 94 Query: 237 TEGAFKDWG 245 +G F Sbjct: 95 GDGPFLQCC 103 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 88.6 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 51/148 (34%), Gaps = 12/148 (8%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GD IG ++ LK + VE+ + ++ + S + + + Sbjct: 6 KLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRY--GLLAGASLDKTNEP--ITDK 61 Query: 88 TLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 LD + G + P + LRQ LD + +RP R + + Sbjct: 62 VLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCR-FCASSLVE 120 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADS 169 + P +DMV N + YA Sbjct: 121 QSPLKSDMVNG-VNFGEQYAARSRSTGG 147 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 88.6 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 44/322 (13%), Positives = 98/322 (30%), Gaps = 71/322 (22%) Query: 27 PIIPYIEGDGIGVD---VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + ++GD + V L ++ + + E+ G + + Sbjct: 2 YKLAILKGD---KESSSVIDRALGIIKS----SVNDSTAFEVTELPFGVNGVLSFNEP-- 52 Query: 84 LPAETLDLIREYRVAIKGP----LTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP- 138 LP +TL ++ Y + G + T ++ VALR+ L++ + + Q + Sbjct: 53 LPNQTLRELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLA---CKAVQISDN 109 Query: 139 ----SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 SP+K+ TD +I R V + Sbjct: 110 NVDASPLKNQIVRDTDFIIV-----------------------QSAKRANDHVDGNISVD 146 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++ A E A+ R VT+V + +T + ++A+ Sbjct: 147 DFAQDTITYEQREVEQVITAGFERAMNRKRA-VTVVTPFDSF-YTSKIWALTAEKIAK-- 202 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 ++V+ V + I+ +P DV+ +++ Sbjct: 203 ------------------IYPDVVVNYVSLSCVISTIIQQPTSLDVVVAPKWVDQVLNEE 244 Query: 313 LAAQVGGIGIAPGANIGDECAL 334 G P + + + Sbjct: 245 SQKITGLPETVPVSMKNNSGQM 266 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 87.8 bits (216), Expect = 8e-16, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 41/79 (51%), Gaps = 5/79 (6%) Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLM 397 HG+APKYAG KVNP +++LS MML+ + EAA I KG++ + Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKH-----LTY 58 Query: 398 DGAKLLKCSEFGDAIIENM 416 D E+ DAII+ M Sbjct: 59 DAGGTASTDEYADAIIKAM 77 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 87.0 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 59/409 (14%), Positives = 118/409 (28%), Gaps = 81/409 (19%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ---DVW 83 P + G G G +V +V+ + + + +Y S + Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAG 90 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSP 140 +P + + A V R ++ LY+ +R + + Sbjct: 91 VPE--IRRLSAEDAA--HYEEWLRARARAGTRVVFRTAINAQSLYL-VR--QRLRAVKVD 143 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + +++ R+ ++ Y G + Sbjct: 144 TLDADGARLLLVRDEAQGFYTGGNTHTPGHVSR------------------------TTE 179 Query: 201 CSEEGTKRLVRAAIEYAIA---NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S E T++L+ A+ A + + +K +GA W A E Sbjct: 180 FSREITEQLLAYALRRAREEWPEGPARIVMAYK---FHLLDGALDAWVRDFAARENIEVG 236 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR-PAEYDVIACMNLNGDYISDALAAQ 316 + D + ++ P + V+ N D + L + Sbjct: 237 VFQP---------------------DTVNRNLVAHPPEDRTVLLAGNEWADIMHLVLLDR 275 Query: 317 VGGIGIAP---GANIGDECAL-----FEATHGTAPKYAGQDKVNPGSIILSAEMML-RHM 367 G G N+ + A+ ++ HG+A G+D +NP + + +A + R++ Sbjct: 276 YGS-GRQEDHCTRNVHLDPAVAELVEYQTVHGSADDLEGRDLLNPVATLRAAAAIAERYV 334 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G T A + A T D + DA IE + Sbjct: 335 GCTGAEAATEAALARLAAAGVRTPDQ------GGKHSTTGVVDAFIEEL 377 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 85.9 bits (211), Expect = 3e-15, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 39/117 (33%), Gaps = 15/117 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ KV+D K + I G S G V L E Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTK---YGHSFLYEAILMGGCSIDATG--VPLTDE 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRS----------LNVALRQELDLYICLRPVRYY 134 + + + G + + LR+ L+L+ LRP Y Sbjct: 59 AIAAAKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 81.6 bits (200), Expect = 5e-14, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 5/103 (4%) Query: 16 LQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 ++ + I + GDG+G +V P + V+ A S+ E+ G + Sbjct: 30 IRCAANTPKKRYTIAVLPGDGVGNEVIPVAVDVLCLAG---SLEGIDFSFEELPIGGVAL 86 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 + G V LP ETL ++ + G + I +++ Sbjct: 87 DLVG--VPLPKETLIRAKQSDALLLGAVGWYGIITITFVHLKF 127 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 81.6 bits (200), Expect = 5e-14, Method: Composition-based stats. Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Query: 335 FEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 +E G+AP AG++ NP + ILS M++R+ M +D I + + T D Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 394 ERLMDGAKLLKCSEFGDAI 412 D K ++ GD I Sbjct: 71 AN--DKEKCESTNDIGDII 87 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 78.2 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 30/72 (41%) Query: 345 YAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK 404 + NP ++ +A ML ++G A LI + T D + + + Sbjct: 2 ICRXNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVG 61 Query: 405 CSEFGDAIIENM 416 EF +A+I+N+ Sbjct: 62 TKEFAEAVIDNL 73 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 78.2 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GD IG +V ++ V+ + E ++ + E+ G + G+ ++ Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQE--ILSTYRLEFTELDWGTARYKRTGK--YM 62 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQEL 122 PA+ L ++ + I G + P IR L+ +R+ Sbjct: 63 PADGLSTLKTFHAGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 77.0 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 46/136 (33%), Gaps = 6/136 (4%) Query: 283 DAFLQQILLRPAEYDV--IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHG 340 DA + + + + + A+ + A ++ + HG Sbjct: 153 DANVLSFIKHSQYSKANQVVSSMEGANVLKALYASIYKSLNRAHTLIEVEDGYITMPMHG 212 Query: 341 TAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 AP G NP +++++ +L G+ E A + +E A + D Sbjct: 213 HAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVENQIESAFYENR----DQTTPDQG 268 Query: 401 KLLKCSEFGDAIIENM 416 +L ++ ++E + Sbjct: 269 GVLNTEKYMAMMVECI 284 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 75.5 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%) Query: 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMD 398 G+AP AG++ NP + ILS M++R+ M + AD I + A+ T D + + Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVNE 61 Query: 399 GAKLLKCSEFGDAIIENM 416 + S+ GD I + Sbjct: 62 --THISTSDMGDVISNIL 77 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 NP ++++ A MLRH+ ++ I + + A V R D EF Sbjct: 155 IANPTAMLMCASKMLRHVNLQHYSESIRNAIREVLAAGKV-----RTRDLGGSSSTHEFT 209 Query: 410 DAIIENM 416 DA+I+ + Sbjct: 210 DAVIKAI 216 Score = 72.0 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 41/106 (38%), Gaps = 14/106 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 E I GDG+ ++ ++ V+ A S ++ + K Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAIGAPIDFETILFSEVQHSSSAKV---------- 112 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYIC 127 + + I R+ + G L +P G +++L++ LR+ LDL Sbjct: 113 -EDVIKSINRNRICLMGALMSPDVSYSGELQNLHMKLRKGLDLIAN 157 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 37/107 (34%), Gaps = 13/107 (12%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG+++T +KV+ A K +R S G + Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSAFSLK----KRTFDLRSELIDGCSIDTDGTP--IT 415 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLY 125 + + + + P G+R + LR+ ++ + Sbjct: 416 KTVIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 59/344 (17%), Positives = 120/344 (34%), Gaps = 63/344 (18%) Query: 39 VD--VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 + V PA L+++++A +W ++ G R+ Sbjct: 18 PEASVLPAALELLESA-------GLTANWR--IVAGQAPDGDGG------------RKPE 56 Query: 97 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 156 + P P G L A R+ + + V+ ++++FR Sbjct: 57 AGLLPPFAEP-GASAYGLARAARRAWGGTFSV-----IERRGPLVRSDGTVNVLLFRYEL 110 Query: 157 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 216 + G+E++++S + ++K E + PE +GI+ + + VR A+ Sbjct: 111 DMSDTGMEFESNSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGM 167 Query: 217 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIV 276 D D + + HKGN +K T+G F + +++ I Sbjct: 168 CRRLDVDDLVVAHKGNSIKHTDGLFALTAAE-----------------TLESLAGAAGIA 210 Query: 277 IKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG--IGIAPGANIGDECAL 334 + +I D +++ P +Y I + D ++ ALA Q+ +G+ + L Sbjct: 211 WRSLIIDHMAAELVRNPLDYRAILTHSSFADLLAAALAGQMTTDQLGVCTTYDPAGRP-L 269 Query: 335 FEATHGTAPKYAGQDKVNP--------GSIILSAEMMLRHMGWT 370 F H A + D +P S + + + H+ Sbjct: 270 F--GHDPALDTSAPD-ADPERWRVRRLASTLAAGAALAEHLRLP 310 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 71.6 bits (174), Expect = 5e-11, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 9/81 (11%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ ++ K+ +AA I W + + +P++ Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA-------NAPIEWDPVDV--TPVKGDDGIFRIPSK 77 Query: 88 TLDLIREYRVAIKGPLTTPVG 108 ++L+R ++ +KGPL TP Sbjct: 78 CIELMRINKIGLKGPLATPNW 98 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 67.0 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 33/86 (38%), Gaps = 11/86 (12%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++T ++ ++ + I W + S Sbjct: 3 TKYGGVYTVTLIPGDGIGNEITDSVKEIFEYV-------NAPIEWEQYNVSGMS----SA 51 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP 106 L + ++ +R RV +KG L TP Sbjct: 52 GEDLFKQAVESLRRNRVGLKGILFTP 77 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 65.1 bits (157), Expect = 5e-09, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 33/86 (38%), Gaps = 4/86 (4%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG + P L+V DAA + + + + +G+ P Sbjct: 3 SYRIAVIPGDGIGKEAVPERLRVPDAAARR-FGFALHCGHFDF-ASSDTRARHGK--LRP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI 111 + D +R Y G + P G Sbjct: 59 DDRFDTLRGYDALFFGAVGRPDTGAA 84 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 64.3 bits (155), Expect = 9e-09, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 46/143 (32%), Gaps = 28/143 (19%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + R A+ + + + + +LDLY+ R + G Sbjct: 104 DEYFHSVLRNRTAV--HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKCRF---P 158 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ I+ +E+ E + S++G Sbjct: 159 GVDIQLIGQNNMGIFNELEYSPVEGVVE-----------------------ALSVVSQKG 195 Query: 206 TKRLVRAAIEYAIANDRDSVTLV 228 + +R A + A R VTL+ Sbjct: 196 NDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 63.5 bits (153), Expect = 1e-08, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 334 LFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADL 375 +FE HG+AP AG++ NP + I S ML RH G A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 62.8 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 33/152 (21%), Positives = 58/152 (38%), Gaps = 29/152 (19%) Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 + HKGN +K+T+G F +A++E + D G I+ + +I D Sbjct: 1 MTHKGNSIKYTDGLFAV----VAKQELEKLIGDSG-------------IIQESLIIDHMA 43 Query: 287 QQILLRPAEYDVIACMN---------LNGDYISDALAAQVGGIGIAPGANIGDECALFEA 337 ++ P +Y I L+G +D IG A G + AL A Sbjct: 44 AELTRNPQDYRAILTHGAFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDPA 102 Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 H AP+ ++ +L+ ++ H+ Sbjct: 103 RHTRAPEAEAAGRLRSV--LLAGSLLADHLDQ 132 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.2 bits (147), Expect = 6e-08, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 34/105 (32%), Gaps = 29/105 (27%) Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + +G+ +GD LF + ++ NP + +L++ MML H+ Sbjct: 25 VGPELMAAVGVIECLKLGD--GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHL---- 78 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D C +F +A+I + Sbjct: 79 -----------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 58.9 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 5/72 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA R +E G K ++Y V L E Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIE---GYKFNEMYLDTVCLNIE 62 Query: 88 T--LDLIREYRV 97 T I+ Sbjct: 63 TACFATIKCSDF 74 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 58.5 bits (140), Expect = 4e-07, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 23/54 (42%), Gaps = 3/54 (5%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I + GDGIG ++ +KV++ A EK + G + +G Sbjct: 9 SKQILILPGDGIGPEIMTEAVKVLELANEK---YQLGFELTHDVIGGAAIDKHG 59 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 57.8 bits (138), Expect = 7e-07, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 32/89 (35%), Gaps = 6/89 (6%) Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G LFE + ++KVNP +I S ++L G E A I + A Sbjct: 1 MGIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFGLQEEAGAIQMAVNSAGERG 58 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D C + GD + + Sbjct: 59 MYTTLDTLPKDI----NCDQLGDYLAAAI 83 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 55.5 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 27/61 (44%), Gaps = 5/61 (8%) Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 ++L++ +ML H+ + A++I + +N + +D SE +I+ Sbjct: 1 MLLASCLMLDHLKLHDYANMIRSAILTTMNETRL-----HTVDIGGQGTTSEVVQSIMRI 55 Query: 416 M 416 + Sbjct: 56 I 56 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 55.1 bits (131), Expect = 5e-06, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 25/52 (48%) Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MGW EA LI +E A + T D R M + L EFG+ I+ + Sbjct: 1 EYMGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYIMSVL 52 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.2 bits (121), Expect = 6e-05, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%) Query: 220 NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEI 275 + VT +HK NIMK +G F +LA++ E + P+ I Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLERRGSESGIDTDKPDVCFNI 130 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 50.4 bits (119), Expect = 1e-04, Method: Composition-based stats. Identities = 21/138 (15%), Positives = 43/138 (31%), Gaps = 23/138 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGER 61 + + + +N + + P +E DG M +++ + EK Sbjct: 25 LAPATTCQSLQQRNYGD---KRIKVSQPVVEMDG------DEMTRIIWEFIKEKLILSNV 75 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI---------R 112 + G V + ++ ++Y VA+K TP + + Sbjct: 76 DVELKYYDLGLPYRDQTDDQVTI--DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWK 133 Query: 113 SLNVALRQELDLYICLRP 130 S N +R L + P Sbjct: 134 SPNGTIRNILGGTVFREP 151 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 48.5 bits (114), Expect = 5e-04, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 18/28 (64%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEK 55 I + GDGIG ++ A L+V++A EK Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 48.1 bits (113), Expect = 6e-04, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 7/71 (9%) Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 G I++ + GDGIG ++ ++ +V AA + I W E + Sbjct: 28 GPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAA-------DVVIDWDEQFV 80 Query: 71 GEKSTQVYGQD 81 G + Sbjct: 81 GTEVDPRTNSS 91 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 47.7 bits (112), Expect = 7e-04, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 29/84 (34%), Gaps = 14/84 (16%) Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 ++E A++ A + + L K I+K +G FKD ++ + + + G Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 262 PWLKVKNPNTGKEIVIKDVIADAF 285 W + + D Sbjct: 60 IW-------------YEHRLIDDM 70 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 47.4 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 18/50 (36%), Gaps = 3/50 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 I + GDGIG ++ L+V++A EK G Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEK---TGFDYEIDRRPFGGADIDA 50 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 47.4 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 11/32 (34%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDA 51 + I GDGIG ++ + V Sbjct: 106 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 47.0 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 17/51 (33%), Gaps = 5/51 (9%) Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G E A+ I +E +N D R EF A + Sbjct: 39 HVGEGEKANAIRNAVEKVLN-----IDNVRTGGLGGSATTKEFTAATERRL 84 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 46.2 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 26/78 (33%), Gaps = 13/78 (16%) Query: 352 NPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL- 403 NP + I + L T+ A+ + + I A +T D + G Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 404 -----KCSEFGDAIIENM 416 EF + + EN+ Sbjct: 66 CSDYLNTFEFMEKLGENL 83 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 44.3 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 24/82 (29%), Gaps = 13/82 (15%) Query: 348 QDKVNPGSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 + NP + I + L A + + ++ A ++ D + G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 401 KLLK-----CSE-FGDAIIENM 416 + SE D E + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERL 84 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 42.4 bits (98), Expect = 0.034, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 17/47 (36%), Gaps = 4/47 (8%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + GDGIG ++ ++V+D K + G Sbjct: 2 TKHIAILRGDGIGSEIVAETVRVLD----KLIAQGLDAGYEYAPLGG 44 >UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyaloperonospora parasitica RepID=Q6UB50_9STRA Length = 55 Score = 42.0 bits (97), Expect = 0.040, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 18/50 (36%), Gaps = 2/50 (4%) Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A LI K +E + T D D + ++ G AII M Sbjct: 3 FQMETEAQLIEKAVEQVLLDGMRTGDL--TKDKSAVVGTKTMGAAIIAKM 50 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 441 e-122 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 431 e-119 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 418 e-115 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 415 e-114 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 407 e-112 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 402 e-110 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 402 e-110 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 400 e-110 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 396 e-109 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 396 e-108 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 391 e-107 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 390 e-107 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 389 e-106 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 387 e-106 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 386 e-106 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 385 e-105 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 382 e-104 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 377 e-103 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 376 e-103 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 375 e-102 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 374 e-102 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 368 e-100 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 365 2e-99 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 359 2e-97 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 359 2e-97 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 357 3e-97 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 356 7e-97 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 356 8e-97 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 356 1e-96 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 355 1e-96 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 354 3e-96 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 353 6e-96 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 353 6e-96 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 352 1e-95 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 350 4e-95 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 349 8e-95 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 349 1e-94 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 348 3e-94 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 347 6e-94 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 345 1e-93 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 345 1e-93 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 344 4e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 342 1e-92 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 342 2e-92 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 342 2e-92 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 342 2e-92 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 341 3e-92 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 340 5e-92 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 337 4e-91 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 4e-91 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 337 5e-91 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 336 8e-91 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 336 8e-91 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 335 2e-90 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 334 3e-90 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 334 5e-90 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 334 6e-90 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 333 7e-90 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 333 7e-90 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 333 8e-90 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 333 9e-90 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 333 1e-89 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 332 2e-89 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 330 6e-89 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 330 8e-89 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 329 9e-89 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 328 2e-88 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 327 4e-88 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 327 7e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 326 7e-88 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 326 9e-88 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 326 1e-87 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 325 2e-87 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 325 2e-87 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 325 2e-87 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 325 2e-87 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 325 2e-87 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 324 3e-87 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 323 6e-87 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 323 9e-87 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 322 1e-86 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 322 1e-86 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 322 2e-86 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 320 5e-86 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 320 7e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 319 1e-85 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 318 2e-85 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 318 2e-85 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 317 4e-85 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 317 4e-85 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 317 4e-85 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 316 1e-84 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 315 2e-84 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 313 6e-84 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 313 6e-84 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 313 7e-84 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 312 1e-83 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 311 3e-83 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 309 1e-82 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 309 1e-82 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 308 2e-82 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 308 2e-82 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 308 2e-82 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 308 3e-82 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 308 3e-82 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 307 5e-82 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 304 3e-81 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 304 5e-81 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 303 1e-80 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 303 1e-80 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 302 2e-80 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 300 4e-80 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 300 5e-80 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 300 8e-80 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 300 9e-80 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 300 9e-80 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 299 1e-79 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 298 2e-79 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 297 7e-79 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 295 2e-78 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 295 3e-78 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 294 3e-78 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 293 8e-78 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 290 6e-77 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 290 7e-77 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 289 1e-76 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 284 4e-75 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 283 8e-75 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 283 9e-75 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 282 2e-74 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 282 2e-74 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 279 1e-73 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 278 2e-73 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 278 3e-73 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 277 8e-73 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 271 3e-71 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 269 1e-70 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 267 6e-70 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 263 6e-69 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 263 7e-69 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 263 7e-69 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 262 1e-68 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 259 1e-67 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 259 2e-67 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 258 3e-67 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 251 4e-65 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 250 8e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 249 1e-64 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 248 2e-64 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 247 6e-64 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 246 1e-63 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 244 6e-63 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 241 4e-62 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 236 1e-60 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 234 5e-60 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 233 7e-60 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 230 9e-59 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 228 3e-58 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 225 3e-57 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 223 8e-57 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 221 4e-56 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 218 4e-55 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 218 4e-55 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 214 4e-54 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 213 9e-54 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 212 2e-53 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 211 5e-53 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 207 8e-52 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 204 3e-51 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 203 9e-51 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 195 2e-48 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 193 1e-47 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 193 2e-47 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 186 1e-45 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 181 3e-44 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 179 1e-43 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 179 2e-43 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 173 1e-41 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 171 3e-41 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 171 3e-41 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 171 4e-41 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 169 2e-40 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 159 2e-37 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 157 5e-37 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 154 6e-36 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 154 6e-36 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 154 8e-36 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 151 5e-35 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 149 2e-34 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 134 7e-30 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 126 1e-27 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 118 3e-25 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 117 6e-25 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 116 2e-24 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 109 2e-22 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 103 1e-20 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 103 1e-20 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 101 5e-20 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 96 2e-18 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 92 4e-17 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 91 8e-17 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 90 2e-16 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 90 2e-16 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 84 9e-15 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 80 1e-13 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 80 1e-13 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 78 6e-13 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 78 6e-13 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 77 2e-12 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 75 5e-12 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 72 5e-11 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 71 8e-11 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 67 1e-09 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 66 2e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 62 3e-08 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 62 4e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 61 6e-08 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 59 4e-07 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 58 8e-07 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 57 2e-06 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 55 4e-06 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 54 9e-06 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 54 1e-05 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 52 3e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 52 4e-05 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 50 1e-04 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 49 5e-04 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 47 0.001 Sequences not found previously or not previously below threshold: UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 45 0.004 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 44 0.007 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 44 0.007 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 44 0.012 UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyalop... 42 0.032 UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot... 42 0.033 CONVERGED! >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 441 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 327/416 (78%), Positives = 369/416 (88%), Gaps = 1/416 (0%) Query: 2 ESKVVVPAQGKKITLQNG-KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ L+VP+NPIIP+IEGDGIGVD++P M+KVVDAAVEKAYKGE Sbjct: 3 YQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+C RPVR+++G PSPVK P DMVIFRENSEDIYAG+EWKA S +AEKVIKFL Sbjct: 123 QLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLT 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++YA+ NDR SVTLVHKGNIMKFTEGA Sbjct: 183 EEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGA 242 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY++AR+EFG EL+DGGPW++ KNP TGK +V+KDVIADA LQQILLRPAEYDVIA Sbjct: 243 FKDWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIA 302 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAA+VGGIGIAPGAN+ D A+FEATHGTAPKYAGQDKVNPGS+ILSA Sbjct: 303 TLNLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSA 362 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGWTEAADLI+KG GAI AKTVTYDFERLMDGA LL CSEFGDA+I M Sbjct: 363 EMMLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 431 bits (1108), Expect = e-119, Method: Composition-based stats. Identities = 307/416 (73%), Positives = 360/416 (86%), Gaps = 1/416 (0%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+ Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAAQVGGIGIAPGAN+GDE A+FEATHGTAPKYAG++KVNPGS+ILSA Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 291/419 (69%), Positives = 346/419 (82%), Gaps = 8/419 (1%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+ Sbjct: 8 LQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query: 65 WMEIYTGEKSTQVYGQD-------VWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA 117 W E++ GEK Q + WL +T++ I Y+V+IKGPLTTP+G G RSLNVA Sbjct: 68 WYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 LRQ++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I Sbjct: 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 FL+ E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+T Sbjct: 187 FLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query: 238 EGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 EGAF WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY Sbjct: 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYS 306 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSII 357 VIA MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSII Sbjct: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LSAEMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM Sbjct: 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 221/422 (52%), Positives = 291/422 (68%), Gaps = 10/422 (2%) Query: 2 ESKVVVPAQGKKITLQNGK---LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 K+ VP G+KITL+ G + VP+NPIIP I GDGIG DV PA KV++AA E Sbjct: 3 YDKIEVPDAGEKITLKEGSEDEIEVPDNPIIPIIHGDGIGKDVGPAAQKVLEAAAE---A 59 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R ISWM +Y GE + + YG+DV LP ET+D IRE+RVAIKGPLTTPVG G RSLNVAL Sbjct: 60 TGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LDLY +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + +EMG + GIG+KP +E+G+KRLVR AI+YA+ +DRD VTLVHKGNIMKFTE Sbjct: 180 VEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F DWG ++A EE+ + + P W + ++ +++++ +ADA LQ + LR Sbjct: 240 GQFGDWGMEVADEEYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+D++A NLNGDY+SDA AQ+GG+GIAPG N G L E HG+APK AGQD NP Sbjct: 300 EFDILAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGKGRMLAEPVHGSAPKRAGQDMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M ++GW +AADLI +E I++ VTYD ER ++ A+ L SE+ D I++ Sbjct: 360 AMILSGRLMFDYLGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVD 419 Query: 415 NM 416 + Sbjct: 420 TI 421 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 407 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 260/422 (61%), Positives = 313/422 (74%), Gaps = 17/422 (4%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 +KIT LNVP PIIP+I GDGIG D+ A +V+DAAVEKAY GE++I W E+ Sbjct: 2 TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVL 61 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 G+K+ G+ WLP ETLD I+EY +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLR Sbjct: 62 AGQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLR 119 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PVR+++G PSPVK P+ DMVIFREN+EDIYAGIE+K + + +KVI FL+ EMG IR Sbjct: 120 PVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIR 179 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 FPE GIGIKP S+EGT+RLVRAAI+YAI N+R SVTLVHKGNIMKFTEG+FK WGY LA Sbjct: 180 FPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239 Query: 250 REEFGGELIDGGPWLK-------------VKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 EFG ++ + + + +I+IKD IAD FLQQIL RPAE+ Sbjct: 240 LTEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEH 299 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIG--DECALFEATHGTAPKYAGQDKVNPG 354 DV+A MNLNGDYISDALAAQVGGIGIAPGANI A+FEATHGTAPKYAG +KVNP Sbjct: 300 DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPS 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 S+ILS+ +ML H+GW EAAD I +E I +K VTYDF RLMDGA+ + S F D +I+ Sbjct: 360 SVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIK 419 Query: 415 NM 416 N+ Sbjct: 420 NL 421 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 206/415 (49%), Positives = 295/415 (71%), Gaps = 3/415 (0%) Query: 2 ESKVVVPAQGKKITL-QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 + VP QG+ I + +NG+ +P PII YI+GDG+G DV P M KVVD+A+ Y+ + Sbjct: 6 YQHINVPEQGQSIKIAKNGQWQIPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAK 65 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI WM++Y GE++ ++Y W P ET++ +RE ++AIKGPLTTP+GGG RSLNVALRQ Sbjct: 66 RKIHWMQVYNGEQAAKLY-DGDWFPQETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQ 124 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 E+DL++ +R ++ + PSP+K+P LT++ + R++SED+Y+GIEW+A S ++EKV+ FL Sbjct: 125 EMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLC 184 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGV ++RF + CGIGIK S+EG++RLVR AI YA+ N+ +S+TLVHKGN++KFT+GA Sbjct: 185 EEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGA 244 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK WG+ LA+ E+ + G WL + ++IK+VIAD LQQ L+ P ++DV+A Sbjct: 245 FKRWGFALAKREYQAIDDENGRWLHIPR-QGQPPLIIKEVIADNMLQQCLMHPEQFDVVA 303 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 N NGD+++D L+AQVGG+GI P AN+ +E A FE THGT + AGQ+K NP S ILSA Sbjct: 304 TTNQNGDFLADMLSAQVGGVGIMPAANLNNEVAFFEPTHGTFARIAGQNKANPSSSILSA 363 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ML+ M W EAA+LI +E + A VT+D + L C++F +IE+ Sbjct: 364 VLMLKFMQWHEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 402 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 235/471 (49%), Positives = 304/471 (64%), Gaps = 56/471 (11%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G+KIT QNG+ VP+NPI+P+I GDG G+D+ PA KV+DAAV KAY G+ Sbjct: 1 MYEKITPPSTGEKITFQNGEPIVPDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGK 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISW ++Y G+++ +YG +LP +TL I+EY +AIKGPLTTP+GGGIRSLNVALRQ Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K P+ D++++REN+EDIY GIEWK S E++I L Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 ++ K + P GIGIKP S G++RLVR A+++A+ ++ VTLVHKGNI Sbjct: 181 KDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MK+TEGAF+DWGY+LA +EF E + Sbjct: 241 MKYTEGAFRDWGYELATQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTP 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W + ++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKKAQIVKEVETVINSIWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD CA+FEATHGTAPK+AG DK+NPGS+ILS MML Sbjct: 361 GDYLSDAAAAIVGGLGMGPGANIGDSCAIFEATHGTAPKHAGLDKINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA-KLLKCSEFGDAIIEN 415 +MGW EAADLI +G+ +I VTYD RLM+ + LKCSEF D II+ Sbjct: 421 YMGWQEAADLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 196/423 (46%), Positives = 274/423 (64%), Gaps = 13/423 (3%) Query: 2 ESKVVVPAQGKKITLQN-GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K + P G+ + G+L VP+ +I YIEGDGIG +V A +KV + AVEKAY Sbjct: 19 TGKYIDPPSGEYVKYTGPGQLKVPDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKS 78 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 R+I+W EI GEK+ +++G LP ++++++R+ RV +K PL TPVGGG RS+NV LRQ Sbjct: 79 RQITWYEIVVGEKAEKLFGN--RLPDQSIEVLRKIRVFLKAPLETPVGGGFRSINVTLRQ 136 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ED+YAGIEW +S +A K+ +FLR Sbjct: 137 LFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLR 196 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 E GV + GIGIKP S+ GT+R+ R A+++AI N R VT++HKGNI K+TEGA Sbjct: 197 REFGV---NIRDDAGIGIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGA 253 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK+W +++AR EF ++ + ++++ D IAD LQQ+L R EYDVI Sbjct: 254 FKEWAFEVARNEFREHVVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVIL 313 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A VGG+G+APG ++GD + E HGTAPKY G++ VNP + IL+ Sbjct: 314 APNLNGDYVSDEAAGLVGGLGVAPGLDVGDWGMMAEPVHGTAPKYRGKNYVNPTATILAL 373 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERL-------MDGAKLLKCSEFGDAII 413 E+M R +GW E A+ I+KG+E A T D R M ++L EF D ++ Sbjct: 374 ELMFRFLGWREVAEYIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVV 433 Query: 414 ENM 416 E + Sbjct: 434 EII 436 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 396 bits (1017), Expect = e-109, Method: Composition-based stats. Identities = 196/416 (47%), Positives = 263/416 (63%), Gaps = 8/416 (1%) Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 + P++G+ +NGKL VP+N I+ Y +GDGIG ++ + KV+DAAV+KAY G R+ Sbjct: 9 DEAKPPSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRR 68 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I W E+ GE++ + G LP TL + RV +KGPLTTPVGGG RSLNV LR L Sbjct: 69 IVWWEVTAGEEAQKECG--SLLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVL 126 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY +RPV++Y G P+P HPE D VIFREN+ED+YAGIEW DS +A+K+ FL++E Sbjct: 127 DLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKE 185 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 G I GIGIKP S+ T+R VR A+E+AI N VT++HKGNIMK+TEGAF+ Sbjct: 186 FG---IELTPDTGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFR 242 Query: 243 DWGYQLAREEFGGELIDGGPWLK-VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 W Y L EF ++ +I++ D IAD LQQI+ RP EY+VI Sbjct: 243 QWAYDLILSEFRDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVT 302 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 NLNGDYISD A VGGIG+A G ++GD A+ E HG+APKYAG++ +NP + ILS Sbjct: 303 PNLNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSGM 362 Query: 362 MML-RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +L +GW E L+ ++ AI K VTYD R M G + +E+ D +++ + Sbjct: 363 YLLSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 396 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 216/422 (51%), Positives = 289/422 (68%), Gaps = 12/422 (2%) Query: 2 ESKVVVPAQGKKITL---QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 KV VPA+G+KI + N +L++PENPI+P I GDGIG DV PA KV++AA Sbjct: 5 YDKVEVPAEGEKIEVVDEDNDELDIPENPIVPIIHGDGIGKDVGPAAQKVLEAAA---NA 61 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R+ISWM ++ GE + + Y ++ LP +T++ I E+RVAIKGPLTTPVG G RSLNVAL Sbjct: 62 TGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LD Y +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + E+MG + GIGIKP +E G+KRLVR AI+YAI +DRD VTLV KGNIMKFTE Sbjct: 180 VEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F +WG ++A EE+ + + P W + ++ ++++ +ADA LQ + LR Sbjct: 240 GQFTEWGMEVADEEYPDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+ V+A NLNGDY+SDA AQ+GG+GIAPGAN GD L E HG+APK AGQ+ NP Sbjct: 300 EFSVLAMPNLNGDYLSDAAGAQIGGLGIAPGANFGDARVLAEPVHGSAPKRAGQNMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M +MGW +AADL+ +E I++ TVTYD ER ++ A+ L E+ DAI+E Sbjct: 360 AMILSGRLMFDYMGWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVE 419 Query: 415 NM 416 N+ Sbjct: 420 NI 421 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 212/421 (50%), Positives = 284/421 (67%), Gaps = 17/421 (4%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 +K+T+ NG+L VP NP IP+IEGDGIG ++ A V DAAV+KAY G+++++W+ + Sbjct: 2 TEEKVTMNNGQLQVPNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLL 61 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 GE + + GQ WLP +TL +REY V IKGPLTTP+G G RS+NV LRQ+LDLY C R Sbjct: 62 AGETAYKKTGQ--WLPDKTLATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFR 119 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PV YY GTPSPV HPE ++ +FREN+EDIYAGIE D+ DAE+ L ++ + K+R Sbjct: 120 PVTYYPGTPSPVVHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVR 179 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 FP+ IKP S++G+ RLV AAI+YA AN+R ++TLVHKGNIMK TEG FK WGY+ A Sbjct: 180 FPDTSAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAA 239 Query: 250 REE------------FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 + + + + +++++ DVI D F QQ LL P ++ Sbjct: 240 EKYGDKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFE 299 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIG--DECALFEATHGTAPKYAGQDKVNPGS 355 V+A MNLNGDYISDALAAQVGGIGIAPG NI A+FEATHGTAP++AGQ+K+NP S Sbjct: 300 VVATMNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTS 359 Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 IILS MM ++GW + ++LI G++ AI + VT DF + D A +L S FG+ + + Sbjct: 360 IILSGAMMFDYLGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPD-ATVLSTSGFGEYVAQL 418 Query: 416 M 416 + Sbjct: 419 I 419 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 390 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 185/420 (44%), Positives = 263/420 (62%), Gaps = 12/420 (2%) Query: 2 ESKVVVPAQGKKITLQNGK-LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 E K +P +G+ I L+ K L VP+NPIIP+IEGDGIG ++T AML +++ AVEK Y G Sbjct: 13 EGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGS 72 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +KI W+E+ G+K+ + G+ LP ETLD+++E V IKGPL TPVG G+RS+N ALR+ Sbjct: 73 KKIYWVELLAGDKAEEKTGE--RLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRR 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 D Y +RPV + G +P+ +PE D+V+FREN++D+YAG+E+ A + +A+KV +FL Sbjct: 131 AFDYYSAVRPVYWM-GQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLI 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 +EMG K+ FPE GI +KP SE TKR VR A+ YA+ N++ +V ++ KGNIMK TEGA Sbjct: 190 KEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGA 249 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F +W +++A E G + ++ + VI D L Q++L+P +DVI Sbjct: 250 FINWAFEVAEE----PEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVII 305 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A+ +GG G P NIGD ALFE+THGTA AG+ NP S+ LS Sbjct: 306 AQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSG 365 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFE----RLMDGAKLLKCSEFGDAIIENM 416 MML ++GW EAA + + + T D + AK + EF + I + + Sbjct: 366 AMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 389 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 161/391 (41%), Positives = 220/391 (56%), Gaps = 40/391 (10%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +VT AM V++A + W+ + G + + YG LP Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA-------SGVDLEWIRVEAGVEVIEKYGTP--LPP 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + L+ IRE RVAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + Sbjct: 54 QVLESIRETRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QD 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + +A + + G E IGIKP SE G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGS 167 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+V+ A EYA N R VT VHK NIMKFT+G F ++A+E Sbjct: 168 RRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY-------------- 213 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I +D+I D Q++ +P YDV+ NL GD ISD A +GG+G+APGA Sbjct: 214 ------PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGA 267 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIGD A+FEA HG+APKYAGQ+KVNP ++ILS MMLR++G EAA + ++ I Sbjct: 268 NIGDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAE 327 Query: 387 KT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 VTYD + + E +AI + Sbjct: 328 GKYVTYDLA----QGEPVGTQEMAEAIAARV 354 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 67/405 (16%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 TL+N + + + I GDGIG +++ ++ +V A I W + Sbjct: 10 FSTLRNYSSSTSKIQKVTLIPGDGIGPEISESVKRVFSAVKA-------PIEWETVVVDA 62 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 63 N--------TGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCL 114 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G + + V+ REN+E Y+GIE + Sbjct: 115 SIPGHKTRY---NNVNTVVVRENTEGEYSGIENQPVKGV--------------------- 150 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F +++ Sbjct: 151 --AQSIKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY 208 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 I +++ D Q++L P + DV+ NL GD +SD Sbjct: 209 --------------------PSIKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDL 248 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 A +GG+G+ P NIG+ A+FEA HGTAP AG++K NP ++ILS+ MMLRH+G Sbjct: 249 CAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFH 308 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + + V + D CSE+ D +++ + Sbjct: 309 EASIIENAVLNTLTEGKV-----KTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 233/472 (49%), Positives = 293/472 (62%), Gaps = 57/472 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 +E + K + GIGIKP S+ G++RLVR AI +A + VTLVHKGNI Sbjct: 181 DELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MKFTEG F+DWGY+LA EF E + Sbjct: 241 MKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTE 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W N +++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD A+FEATHGTAPK+AG D++NPGS+ILS MML Sbjct: 361 GDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIEN 415 MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ + Sbjct: 421 FMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 118/391 (30%), Positives = 187/391 (47%), Gaps = 60/391 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG +VT A ++V++A K W G ++ + Y + ++P Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIP 52 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + I R+ +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + Sbjct: 53 KELNESIERTRIGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---P 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+V+ REN+E +Y+GIE + E +K +E+ Sbjct: 110 GVDLVVVRENTEGLYSGIEHEVVPGVVE-----------------------SLKIITEKA 146 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R+ + A YA R + +HK NIMK ++G F +++E Sbjct: 147 STRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY------------- 193 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 EI+ + I D Q+++ P +YD++ NL GD +SD A VGG+G+APG Sbjct: 194 -------PEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPG 246 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIG+ ++FEA HG+AP AG++ NP ++I S +MLRH+ +AA+ + + Sbjct: 247 ANIGERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRHLDEQDAANRVKAAVHHVYR 306 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D SEF D ++E + Sbjct: 307 EGKH-----LTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 123/401 (30%), Positives = 188/401 (46%), Gaps = 60/401 (14%) Query: 16 LQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 + K + + I GDGIG +++ A+ ++ A + I W + + T Sbjct: 1966 VAREKSSSTTIKTVALIPGDGIGPEISAAVQEIFKFA-------DVPIKWESVDVTPRPT 2018 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQ 135 + +P +LD+IR++ + +KGPL TP+G G +SLN+ALR+E +LY +RP + + Sbjct: 2019 E--DGRFRMPQSSLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIE 2076 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G +P K D+V REN+E Y+GIE + Sbjct: 2077 GYETPYK---NVDLVTVRENTEGEYSGIEHVIVDGVVQ---------------------- 2111 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 IK +EE ++R+ R A +YA N R SVT VHK NIM+ ++G F + A Sbjct: 2112 -SIKLITEEASRRVARFAFQYAKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAH---- 2166 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +EI D+ D ++ P +DV+ NL GD +SD A Sbjct: 2167 ----------------HREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNLYGDILSDLAAG 2210 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 +GG+G+ P NIG+ A+FE+ HGTAP AGQD+ NP +++ SA MMLR+M + ADL Sbjct: 2211 LIGGLGVTPSGNIGETGAIFESVHGTAPDIAGQDRANPTALLFSAIMMLRYMNLNKHADL 2270 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + I D CS++ I + Sbjct: 2271 IESAVLATIREAK-----YLTADLGGRSTCSQYTKEICRQI 2306 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 107/408 (26%), Positives = 173/408 (42%), Gaps = 60/408 (14%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A + T K + +N + G GIG +++ A+ + AA I W Sbjct: 287 AMIPRYTFSQKKKSQKQNHKVVLFPGHGIGPEISQAVCDIFAAAK-------VPIDWEHH 339 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 K G + E+L+ + Y+ +KGP TP+G G RSLNV +R++L+L+ + Sbjct: 340 EIYTKPINEAGD--LIKEESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANV 397 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RP R G +P D+V REN+E Y+G+E E Sbjct: 398 RPCRSLAGVKTPYS---NVDLVTIRENTEGEYSGLEHAVVPGVVE--------------- 439 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S+ + + R A E+A N+R V HK +MK +G F + ++ Sbjct: 440 --------NLKIISQPACENIARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKI 491 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + E EI + D ++ P +DV+ NL GD Sbjct: 492 SSEY--------------------PEIEYTEEQIDTVCMKLSKNPEVFDVMVMPNLYGDI 531 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A +GG+G+ NI CA++EA HGTAP AG +K NP +++LS MML+ MG Sbjct: 532 VSDLCAGLIGGLGLTASGNISHTCAVYEAVHGTAPDIAGLNKANPTALLLSGVMMLKAMG 591 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I + + ++ D +++ A+I ++ Sbjct: 592 LQKEGFAIEEAVIKTLSEGK-----FLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 119/390 (30%), Positives = 181/390 (46%), Gaps = 61/390 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA I W E + Q G +P+E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA-------PIQWEERNV--TAIQGPGGKWMIPSE 83 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + + ++ +KGPL TP+ G S+N+ LR+ DLY +RP +G +P Sbjct: 84 AKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DV 140 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++V REN+E Y+GIE + IK +E +K Sbjct: 141 NIVTIRENTEGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASK 177 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A EYA N R +VT VHK NIM+ ++G F ++A Sbjct: 178 RIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE----------------- 220 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + K+I ++ D ++ P+++DV+ NL GD +SD A +GG+G+ P N Sbjct: 221 ---SCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGN 277 Query: 328 IG-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG + A+FE+ HGTAP AG+D NP +++LSA MMLRHMG + A I I Sbjct: 278 IGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKD 337 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D KCS+F + I + Sbjct: 338 GK-----SLTKDLGGNAKCSDFTEEICRRV 362 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 375 bits (962), Expect = e-102, Method: Composition-based stats. Identities = 122/395 (30%), Positives = 180/395 (45%), Gaps = 55/395 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + GDGIG ++ A++ V+ A + I GEK Y Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA-------VPLRLETIEIGEKLYNKY-YTY 52 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV 141 + +T I + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + Sbjct: 53 GITEDTWSQIFRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNT-- 110 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 D+VI REN ED+YAGIE+ +K Sbjct: 111 -SAPEIDVVIIRENEEDLYAGIEYHH-----------------------TADTYESVKLI 146 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S G+++++R A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 147 SRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYS-------- 198 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + D +++ P ++DVI NL GD +SD A G IG Sbjct: 199 ------------NIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIG 246 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +A ANIG + A+FEA HG+AP AGQ+ NP ++ +A MML H+G TE A I ++ Sbjct: 247 LAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALK 306 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T D + + EF AII N+ Sbjct: 307 KTIEDGIHTADIYNPSISSTKVGTKEFAQAIINNL 341 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 374 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 109/389 (28%), Positives = 169/389 (43%), Gaps = 66/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V A + +++ + + G+++ + YG+ LP E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL-------DLPFEYSYYDAGDEALEKYGK--ALPDE 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 TL+ R+ + G + V LR+EL + +RP + +G Sbjct: 54 TLEACRKSDAVLFGAAG----ETAADVIVRLRRELGTFANVRPAKAIEGIECLY---PGL 106 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E +Y G E+ I+ + E ++ Sbjct: 107 DIVVVRENTECLYMGFEFGFG------------------------DVTEAIRVITREASE 142 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A E A R VT +HK N+MK T G F+D ++A++ Sbjct: 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY--------------- 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 EI D DA +++ P +DVI N+ GD +SD A VGG+G+AP AN Sbjct: 188 -----PEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G+ A+FE HG A AG+ NP ++IL+A MMLRH G+ E A + + +E I Sbjct: 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D LK EF + + + Sbjct: 303 KKTPDL------GGNLKTMEFANEVASLL 325 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 115/400 (28%), Positives = 188/400 (47%), Gaps = 63/400 (15%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 G+ + IEGDGIG +++ ++ + AA I W + + + Sbjct: 47 GQKGADGKYTVTLIEGDGIGPEISQSVKDIFSAANA-------PIKWEPVDV---TPILK 96 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 +P + ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G Sbjct: 97 DGKTAIPDDAIESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYK 156 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +P + D V+ REN+E Y+GIE + I Sbjct: 157 TPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQ-----------------------SI 190 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K ++E ++R++R A +YA + ++ V +VHK IMK ++G F + ++A++ Sbjct: 191 KLITKEASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDF------ 244 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQ 316 ++ + D +I+ P Y+ V+ NL GD +SD A Sbjct: 245 --------------PDVEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGL 290 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GG+G+ P NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A I Sbjct: 291 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAGRI 350 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D K SE+ +AI++ + Sbjct: 351 QKAIFDTLAEGK-----ALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 131/417 (31%), Positives = 195/417 (46%), Gaps = 62/417 (14%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 ME A K + NGK + I GDGIG ++ + ++++A Sbjct: 1 MEQSGGSGATMKYVVTPNGKKL------VTLIPGDGIGPEIVESACRLIEAV-------G 47 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 I W G + G +P +T++ I+ RV +KGPL TPVG G +S NV LR+ Sbjct: 48 APIEWEVRRAGASVFRE-GIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRK 106 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 + + +RPVR P+P + D+V+ REN ED+YA IE++ Sbjct: 107 LFEAFANVRPVRELPSVPTPYRG-RNIDLVVVRENIEDLYAAIEYRETPGVT-------- 157 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 I K S +G+++++R A E A A R VT K NI+K TEG Sbjct: 158 ---------------IAHKLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGW 202 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F+ ++A E +I +I D Q++ P +++VI Sbjct: 203 FQHIFEEIASEY--------------------PDIEANHLIIDNCAHQLVKAPEQFEVIV 242 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGD ISD + VGG+G A N G E A+FE HGTAPKYAG++ +NP ++IL+A Sbjct: 243 TTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTA 302 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 MMLR++ E A+ I + + + +T D + + F DAII N+ Sbjct: 303 VMMLRYIDEFETAETIEQALIVTLEEGKALTRDVVGDER---AVSTTAFTDAIIANL 356 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 359 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 112/399 (28%), Positives = 186/399 (46%), Gaps = 71/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG +V P +K+++ E ++ G + + YG LP + Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPED 52 Query: 88 TLDLIREYRVAIKGPLTTPVGG---GIRSLNVALRQELDLYICLRPVRYY-------QGT 137 T++ +E + + G +T+P G +S + LR+ LY +RP+ + + Sbjct: 53 TIEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIA 112 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D+VI REN+ED+Y G E R I Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRE------------------------RLENDTAIA 148 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G++R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 149 ERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY----- 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I D + D+ ++ P ++DVI N+ GD +SD +A + Sbjct: 204 ----------------NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP ANIGD+ ALFE HG+AP AG+ NP + ILS M+ ++G E DLI Sbjct: 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ + K VT D LK + GD I+ + Sbjct: 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEILNYI 340 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 359 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 118/410 (28%), Positives = 184/410 (44%), Gaps = 63/410 (15%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 Q + +IEGDGIG +++ ++ K+ AA I W Sbjct: 20 QPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESCD 72 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 S +P + I + VA+KGPL TP+G G RSLN+ LR+ L+ +R Sbjct: 73 V---SPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVR 129 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 P + +G + E D+V+ REN+E Y+GIE + Sbjct: 130 PAKSIEGFKTTY---ENVDLVLIRENTEGEYSGIEHIVCPGVVQ---------------- 170 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 IK + + ++R++R A EYA A R V +VHK I + +G F + +L+ Sbjct: 171 -------SIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELS 223 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY--DVIACMNLNGD 307 +E ++ ++ + D + +++ P+ Y V C NL GD Sbjct: 224 KEY--------------------PDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGD 263 Query: 308 YISDALAAQ-VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 +SD + G +G+ P ANIG + ++FEA HG+AP AGQDK NP +++LS+ MML H Sbjct: 264 ILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNH 323 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MG T AD I + I + R D A S F +A+I+ + Sbjct: 324 MGLTNHADQIQNAVLSTIASG----PENRTGDLAGTATTSSFTEAVIKRL 369 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 95/426 (22%), Positives = 166/426 (38%), Gaps = 61/426 (14%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 121 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 177 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 178 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 235 Query: 118 LRQELDLYICLRPVRYYQ----GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAE 173 LR L ++ LRP + + E D+++ RE + IY G Sbjct: 236 LRSGLKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFGKPR-------- 287 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNI 233 G K E G + + R+ R A E A R + V K N+ Sbjct: 288 ----------GFSKNENGEEIGFNTEVYATYEIDRIARIAFETAQKR-RGKLCSVDKANV 336 Query: 234 MKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 ++ + ++ +A E ++ + + D Q++ P Sbjct: 337 LEASM-LWRKRVTAMASEY--------------------PDVELSHMYVDNAAMQLVRNP 375 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVN 352 ++D I N+ GD +SD + G IG+ P A++G+ LFE HG+AP AGQDK N Sbjct: 376 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKAN 435 Query: 353 PGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKL-LKCSEFGD 410 P + +LSA M+LR+ +G AA I + ++ T D + + C E G+ Sbjct: 436 PLATVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIY---EAGTKLVGCKEMGE 492 Query: 411 AIIENM 416 +++ + Sbjct: 493 QVLKAV 498 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 356 bits (914), Expect = 7e-97, Method: Composition-based stats. Identities = 110/392 (28%), Positives = 174/392 (44%), Gaps = 66/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIGV+V A L +++ + + ++ G+ + G L Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TAL 52 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ETL+ + E R + G + V LR+E DL+ LRPV+ G P Sbjct: 53 PEETLEAVGEARATLFGAAG----ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY--- 105 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D VI REN+ED+Y G E + + + + Sbjct: 106 PDLDFVIVRENTEDLYVGDE------------------------EYTPEGAVAKRIITRT 141 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ + A +YA VT VHK N++K T+G F+D Y++A E Sbjct: 142 ASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY------------ 189 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ D DA ++ +P E+ I NL GD +SD A +GG+G+AP Sbjct: 190 --------PQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAP 241 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG++ ALFE HG+AP+ AG++ NP ++IL+ +ML+H+ + A I K ++ + Sbjct: 242 SANIGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTL 301 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT D L E I ++ Sbjct: 302 AEGLVTPDL------GGKLGTMEMAAEIARHL 327 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 356 bits (914), Expect = 8e-97, Method: Composition-based stats. Identities = 121/389 (31%), Positives = 182/389 (46%), Gaps = 55/389 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG ++ A+L ++ A + I I GEK + + ++ Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEAR-------IRLETIEVGEKLYVKH-YSSGISEQS 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELT 147 + I V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + Sbjct: 59 WESIERTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL---HPNL 115 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++ I REN ED+YAGIE+ R + +K S G + Sbjct: 116 NLTIIRENEEDLYAGIEY-----------------------RQTHNMYESVKLISRTGCE 152 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 +++R A EYA+ N+R VT + K NIMKF++G F ++A+E Sbjct: 153 KIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEY--------------- 197 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I + I D ++ +P +DVI NL GD ISD A G +G+A AN Sbjct: 198 -----PQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSAN 252 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG+ A+FEA HG+AP AGQD NP ++ +A MML H+G + A LI + I Sbjct: 253 IGEHYAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDG 312 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D K + EF + +++ + Sbjct: 313 MHTADIYNKDHSTKKVGTKEFAEEVVKRL 341 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 112/392 (28%), Positives = 174/392 (44%), Gaps = 65/392 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I IEGDGIG +V PA +V++A + ++E G ++ + G V P Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PE 53 Query: 87 ETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 ET++ I + G T+P G LR+ LDLY +RP + Sbjct: 54 ETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRP----VPGSR 109 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN+E +Y E + I S++ Sbjct: 110 PGVDLVIVRENTEGLYVEQERR------------------------YLDVAIADAVISKK 145 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 146 ASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDF------------ 193 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++D+I D Q+++RP +DVI NL GD +SD A VGG+G+AP Sbjct: 194 --------PLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAP 245 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIGD A+FE HG+AP AG+ NP + ILSA MML ++G EAA + K ++ + Sbjct: 246 SGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVL 305 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D F +A++E + Sbjct: 306 ERGPRTPDL------GGDATTEAFTEAVVEAL 331 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 117/392 (29%), Positives = 174/392 (44%), Gaps = 53/392 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG ++ A LKV+ A ++ +I G K + G + Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVILEA-------GAELEIEKIEIGFKVYSM-GNPSGI 53 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + ++ +V +K P+TTP GGG +SLNV +R+ L LY +RP Y P Sbjct: 54 EPSSWESLKRTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY--APFIHTKH 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN ED+Y GIE R +K + + Sbjct: 112 PGIDLVIIRENEEDLYGGIEH-----------------------RQGVDSFQALKIMTRQ 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 GT+R++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 149 GTERIIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEY------------ 196 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I + I D ++ P +DV+ NL GD +SD G +G+ Sbjct: 197 --------PQIEKEHWIIDIGSAKLADNPQSFDVLVLANLYGDILSDVAVQIAGSVGLGA 248 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG E ++FEA HG+AP+ AGQ+ NP ++L+A ML H+G AD + I Sbjct: 249 SANIGHEYSMFEAIHGSAPRRAGQNVANPSGLLLAAVQMLIHIGQNAVADRVYNAWLKTI 308 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 TYD R + EF +I+N+ Sbjct: 309 EEGIHTYDIFREGVSKVKVGTREFARHVIKNL 340 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 100/404 (24%), Positives = 154/404 (38%), Gaps = 56/404 (13%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG +V P ++V++AA K K+++ G Sbjct: 1 MITNQQYKIAVIPGDGIGNEVVPEGIRVLEAASAK---FGFKLAFTTYDWSCARYHSQG- 56 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGT 137 +P++ ++ +R+ G + P +L + +R+E D Y+ LRPVR G Sbjct: 57 -SMMPSDGIERLRDSDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGV 115 Query: 138 PSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ K P D I REN+E Y+ + G Sbjct: 116 PCPLANKKPGDIDFWIVRENTEGEYS-------------------QVGGRMFAGTEHEFV 156 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + GT R++R A + A R+ VT K N + + + + + E Sbjct: 157 TQEAIFTRRGTDRIMRYAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEY--- 213 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I D + + P +DV+ NL GD +SD Sbjct: 214 -----------------PDIRTDQYHIDILAARFAMSPERFDVVVGSNLFGDILSDLGPG 256 Query: 316 QVGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 G I +AP ANI E ++FE HG+AP AGQ NP I S MML H+G EA Sbjct: 257 ITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIWSGAMMLEHLGQPEA 316 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I++ +E + D D + G I + Sbjct: 317 AAAIMQAIETVLTH----PDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 121/391 (30%), Positives = 174/391 (44%), Gaps = 55/391 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + GDGIG ++T A++ ++ AA + + GE+ G +P Sbjct: 21 PIPVTVAAGDGIGPEITAAVMSILSAA-------GAHLDAEYVEVGEQVYLR-GNTSGIP 72 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E D I RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P Sbjct: 73 QEAWDSIARTRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHP 130 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI REN ED+YAGIE R + +K + G Sbjct: 131 DMDVVIVRENEEDLYAGIEH-----------------------RQTQDVAQCLKLITRSG 167 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 ++R+ R A EYA + R +T + K NIMK T+G F ++ARE Sbjct: 168 SERIARYAFEYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY------------- 214 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 EI I D + + RP +YDV+ NL GD +SD A G +G+ Sbjct: 215 -------PEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQMTGSVGLGGS 267 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 NIG A+FEA HG+AP A +D NP ++L+A MLRH+ A ++ + Sbjct: 268 VNIGSGGAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHLKLDSIAAKVMNAWLCTLE 326 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + F +A+IE + Sbjct: 327 EGIHTVDIAG-AHTKERAGTRRFTEAVIERL 356 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 103/389 (26%), Positives = 174/389 (44%), Gaps = 64/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG ++ PA +KV+DA + + + G + G + Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNN 52 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L+ I+ + G +TT +S+ + +R+ELDLY +RPV+ G + V Sbjct: 53 DLETIKGCDAVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGI-TGVTGRNDF 111 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D +I REN+E +Y+GIE + + +G++ Sbjct: 112 DFIIVRENTEGLYSGIE------------------------EIGPELSWTKRVVTRKGSE 147 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A + A ++ +T+VHK N++K ++ F D Q A Sbjct: 148 RIAEYACKLAKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTA------------------ 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + + +D++ D+ +++RP YD++ NL GD +SD AA VG +G+ P AN Sbjct: 188 ---SANGVEYEDMLVDSMAYNLIMRPERYDIVVTTNLFGDILSDMCAALVGSLGLVPSAN 244 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG++ A FE HG+AP AG+ NP + IL +M+L MG + +I + + + K Sbjct: 245 IGEKYAFFEPVHGSAPDIAGKGIANPLAAILCVKMLLEWMGEPR-SQIIDEAIAYVLQKK 303 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D E G+A+ E + Sbjct: 304 IITPDL------GGTASTMEVGNAVAEYV 326 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 138/405 (34%), Positives = 202/405 (49%), Gaps = 58/405 (14%) Query: 15 TLQNGKLNV--PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 T K++V +I I GDGIG + A LKV++AA +++ G Sbjct: 6 TETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKA-------PLAYEVREAGA 58 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + G +P ET++ IR+ RV +KGPL TPVG G +S NV LR+ + Y +RPVR Sbjct: 59 SVFRR-GIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVR 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + P+P D+V+ REN ED+YAGIE + Sbjct: 118 EFPNVPTPYAG-RGIDLVVVRENVEDLYAGIEHMQTPSV--------------------- 155 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +K S +G++++VR A E A A R V K NIMK EG K Q+A+E Sbjct: 156 --AQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEY 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +I +I D Q++ RP +++VI N+NGD +SD Sbjct: 214 --------------------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDL 253 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + +GG+G AP ANIG+E A+FEA HG+APKYAG++ +NP +++LSA MMLR++ Sbjct: 254 TSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFAT 313 Query: 373 ADLIVKGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI + + +T D G K +E+ +AII+N+ Sbjct: 314 ADLIENALLYTLEEGRVLTGDVVGYDRG---AKTTEYTEAIIQNL 355 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 131/393 (33%), Positives = 189/393 (48%), Gaps = 58/393 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I+GDG+G DV A L V+DA +K I ++ G + + YG + L Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKK---FNLDIEYVPAVAGLNTVEKYGTN--L 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 P ETLD ++E +KGP TTP G + S NV +R+ DLY +RP + PS Sbjct: 59 PKETLDTLKETDCVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--- 115 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 DMVI REN+E +Y+G++++ + + IGI+ + Sbjct: 116 KPNVDMVIVRENTEGMYSGLDFRVN-----------------------QETTIGIRVITR 152 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + +R+V+ A + A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 153 KACERIVKYAFKLAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKK------------ 199 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ D DA Q + +P YDVI NL GD ISD A VGGIG Sbjct: 200 --------HPDVKADDAHVDAITQWFIKQPEFYDVIVTENLFGDIISDEAAMVVGGIGTG 251 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 ANIGD+ A+FE HG+ PKY G DKVNP I+S +MML M + EA I + Sbjct: 252 ASANIGDKYAMFEPIHGSVPKYTGMDKVNPIGTIMSVKMMLDWMDYKEAGKAIEDAVYKV 311 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D KCSE G I + Sbjct: 312 LEEGKI-----LTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 349 bits (896), Expect = 8e-95, Method: Composition-based stats. Identities = 99/403 (24%), Positives = 166/403 (41%), Gaps = 56/403 (13%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I I GDGIG++V A ++VV+ + G I + I G + +G+ Sbjct: 41 ASQKPTYRIASIPGDGIGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR 98 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGT 137 ++ + LD +R++ + G + P L +ALR L LY +RPVR + GT Sbjct: 99 --YVSEDCLDTLRKFDAGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGT 156 Query: 138 PSPVKHP-ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 P+ E D ++ RENSE Y+G G + P Sbjct: 157 KCPLNTATEGIDWMLVRENSEGEYSGQG-------------------GRSHVGQPWEAAT 197 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + + G +R++R A E A + R +T+V K N M+ + ++A++ Sbjct: 198 EVAMFTRVGIERIMRFAFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDF---- 253 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ DA +++ +P D I NL+ D +SD AA Sbjct: 254 ----------------PDVTWDKMLVDAMTVRMVAKPQSIDTIVGTNLHMDILSDLAAAL 297 Query: 317 VGGIGIAPGANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 G IG+AP +N+ ++FE HG+A G+ NP + SA ML +G EAA Sbjct: 298 AGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLSWLGEKEAA 357 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +E A +T D DA+ + + Sbjct: 358 KQLMDCVEKVCAAGILTPDL------GGTSNTQGVVDAVKKEI 394 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 349 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 102/396 (25%), Positives = 162/396 (40%), Gaps = 63/396 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + I IEGDGIG +V PA V++A K ++E G ++ + G V Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV 53 Query: 83 WLPAETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P TL+ + + G T+P G +R++LDL+ +RP +++ Sbjct: 54 --PEATLEAVTHTDATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHHP----V 107 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 D+++ REN+E +Y E I Sbjct: 108 PGSRPGVDLIVVRENTEGLYVEQERSYLEG----------------------EIAIADTV 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + + R+ A A + R + + HK N++ T+G F + A Sbjct: 146 ITRKASARIGEYAARLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARF-------- 197 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 E+ +D+I D Q++ P +DVI NL GD ISD A VGG+ Sbjct: 198 ------------PEVKTQDIIIDNCAMQLVRNPERFDVIVTTNLFGDIISDLTAGLVGGL 245 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 GIA NIG + A+FE HG+AP AG+ NP + ILS MML H+G EAA + + Sbjct: 246 GIAASGNIGIKHAVFEPVHGSAPDIAGKGIANPAATILSGVMMLDHLGEHEAARRVEAAV 305 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D +F +A+ ++ Sbjct: 306 DKVLQEGPRTPDL------GGNATTLQFAEAVARSL 335 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 107/401 (26%), Positives = 166/401 (41%), Gaps = 69/401 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GDGIG +++ + L +++A + + ++ G+ + G+ Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAIND---NFPLSLEIKKLEAGDAVLKNTGK-- 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 LP ET + I+ +K P+ + + V LR+ LDLY +RP + Y PS Sbjct: 56 ALPDETFEAIKNSDACLKAPVG----ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D+VI REN+ED+Y G E+ + + S Sbjct: 110 -RDDVDLVIVRENTEDLYTGEEFDIG------------------------DAAVAFRIIS 144 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ +KR+ A A VT VHK N+MK T+G F ++A + Sbjct: 145 EKASKRIANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDF---------- 194 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ +++ DA ++ +P +DVI NL GD +SD A VGG+G+ Sbjct: 195 ----------PDVKFEEMYVDACAMNLIRQPQLFDVIVTTNLFGDILSDESAQVVGGLGM 244 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EAADL 375 AP ANIGD LFE HG A AG+ NP S ILS +MML +G E Sbjct: 245 APAANIGDNFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLDWLGNKHNDQKCIEVGQK 304 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D EF II + Sbjct: 305 LEDVVYDIVKNNIKTKDI------GGDKTTMEFTKEIISRL 339 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 347 bits (889), Expect = 6e-94, Method: Composition-based stats. Identities = 115/390 (29%), Positives = 180/390 (46%), Gaps = 56/390 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + GDG+G ++ ++L+++ A +I I G+K + G + Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA-------GAEIQIDTIEIGQKIYEK-GWPSGISD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P Sbjct: 54 SGWETLKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----K 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN ED+Y+GIE+ R K +E + Sbjct: 109 MDIVIIRENEEDLYSGIEY-----------------------RQTLDTYNCTKVITESTS 145 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 146 ERICRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEY-------------- 191 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I ++ I D +I P ++DVI +NL GD ISD A G +G+ Sbjct: 192 ------PDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGLGGSI 245 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+E A+FEA HG+AP A QD NP ++ +A ML ++G E A + + + Sbjct: 246 NIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKS 305 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + + +F + II N+ Sbjct: 306 GVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 57/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I DGIG +V A L+V++A +++ G+ I G + G V + Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKRS--GDFSIHTETFDWGSDYYKKNG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ ++++ G + P L + + Q D Y +RP + G P+ Sbjct: 58 PADGLEQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 ++ P D VI RENSE Y+G +A PE G + Sbjct: 118 RNCGPGDLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVA 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G R++R A + A A R +T+V K N + + + ++++E Sbjct: 159 IFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ ++ DA ++ L+P D I NL+ D +SD A G Sbjct: 212 -------------PDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHADILSDLAGALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+AP ANI E ++FE HG+A G+ NP + +A ML H+G +AA + Sbjct: 259 LGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFWTAAQMLEHLGEKDAATRL 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E A +T D + DA+ E + Sbjct: 319 MSAVERVTEAGILTPDV------GGTADTQQVTDAVCEAI 352 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 99/399 (24%), Positives = 160/399 (40%), Gaps = 55/399 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGIG +V LKV+ +K Y + + +G+ + Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADM--FLWNSEYYLQHGR--MM 57 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P LD+++ Y + G + P + L + +R+ Y+ LRPV+ +G P Sbjct: 58 PENGLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 142 KHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 H E + VI REN+E Y+ G + + Sbjct: 118 IHQERPINFVIVRENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTI 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +GT+R+ R A +YA + V K N + + + + +A E Sbjct: 159 ITRKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEY-------- 210 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I ++ DA + RP VI NL GD +SD +A VGG+ Sbjct: 211 ------------PDIQLEKYYIDALAAYFVQRPDTLQVIVASNLFGDILSDLGSALVGGL 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GI+P ANI E ++FE HG+AP AG+ K NP + I SA +ML+ +G + A +I+ Sbjct: 259 GISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E D +E G+ I+ + Sbjct: 319 KAIEKVTEHGEK-----LTEDLGGNSTTAEMGEEIVRQI 352 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 99/406 (24%), Positives = 170/406 (41%), Gaps = 63/406 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG +V +KV++ EK K+++ E + G + G L Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEK---FGFKLNFNEFFVGGAAIDHCGYP--L 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT 137 PAETL E + G + P R + LR+ L+ LRP Y+G Sbjct: 57 PAETLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGL 116 Query: 138 P--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 P++ + DMV+ RE + IY G + ++ Sbjct: 117 EKFCPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTK----------------- 159 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ RAA E A+ + VT V K N++ + +++ ++A++ Sbjct: 160 --AFDTEVYYKYEIERIARAAFEAAMKRN-KKVTSVDKANVL-QSSILWRETVTEMAKDY 215 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 E+ ++ + D Q++ P +DV+ C N+ GD ISD Sbjct: 216 --------------------PEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDE 255 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 A G +G+ P A++ + L+E G+AP AG+ NP + ILSA MMLR+ Sbjct: 256 AAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLN 315 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EAAD I ++ + + T D D + + +E G I + + Sbjct: 316 EAADAIESAVQKVLASGHRTADLA---DDSTPVSTAEMGTLITQAI 358 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 116/400 (29%), Positives = 169/400 (42%), Gaps = 61/400 (15%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 L + I GDGIG + + A+ ++ A I + EI Sbjct: 13 QPLKYGGKYTVTLIPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNK 65 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGT 137 L E + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G Sbjct: 66 SSGDAL-HEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGF 124 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D I REN+E Y+G+E ++ E Sbjct: 125 KT---RHDNVDFAIIRENTEGEYSGLEHQSVPGVVE-----------------------S 158 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K +E +KR+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 159 LKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDA--- 215 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I KD+I D Q + RP ++DV+ NL G +S+ +A V Sbjct: 216 -----------------ITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALV 258 Query: 318 GGIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ PGAN G + ALFE G+ + NP + ILSA +MLRH+G + ADLI Sbjct: 259 GGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLI 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I D +F AI+E M Sbjct: 319 NAATYSVIEEGK-----TLTKDLGGSASTGDFTHAILERM 353 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 109/407 (26%), Positives = 170/407 (41%), Gaps = 56/407 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + + + + I I GDG G + LKV+ AA K + + G + Sbjct: 7 KEDRTTMQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGK---EGFALETTVLDWGGEYYL 63 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRY 133 G+ LP + ++ ++ Y G + P G + + + LR ELD YI LRPV+ Sbjct: 64 RTGE--VLPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKL 121 Query: 134 YQGTPSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 Y G +P+ K PE D V+ REN+E +YAG G K P Sbjct: 122 YPGVETPIAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTP 162 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + I + +G +R VR A EY R VTL K N++ F ++ ++ Sbjct: 163 DEVAIQTSINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGE 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 E +I DA ++ P +DVI N+ GD I+ Sbjct: 223 EY--------------------PDIERDYAHVDAICMWMVKNPEWFDVIVTDNMFGDIIT 262 Query: 311 DALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 D A GG+GIA G N+ E ++FE G+APKY G++ +NP + + + MML +G Sbjct: 263 DLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVINPLAAVCAGAMMLEQLGE 322 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA I + ++ + L G E GD ++ ++ Sbjct: 323 TGAAARIEEAVKKVCAGH-----LKSLAAGRMGYGTDEVGDLVVSHL 364 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 97/401 (24%), Positives = 158/401 (39%), Gaps = 58/401 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDGIG +V PA + + E G + + G + +G V + Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAETD--GSFTFEFQDFDWGGDYYRRHG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ +R+ + G P + L + + Q LD Y +RP R G P+ Sbjct: 58 PADGLEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 K E D VI RENSE Y+G+ + P + Sbjct: 118 KRCTAEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAATDVS 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R++R A A + R +T+V K N + + + +++RE Sbjct: 159 MMTRAGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + DA +++ RPA D I NL+ D +SD AA G Sbjct: 212 -------------PDVRWDKELVDAATARMVNRPASLDTIVATNLHADILSDLAAALAGS 258 Query: 320 IGIAPGANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GIAP NI ++FE HG+A G+ NP S M+L H+G +AA + Sbjct: 259 LGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGTFWSVVMLLEHLGEHQAAARM 318 Query: 377 VKGMEGAINAKTVTYDFE-RLMDGAKLLKCSEFGDAIIENM 416 ++ +E T D D + A+ +++ Sbjct: 319 MRAVESV------TADQALHTRDLGGTATTEQVTQAVCQHL 353 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 115/425 (27%), Positives = 185/425 (43%), Gaps = 74/425 (17%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPEN-----PIIPYIEGDGIGVDVTPAMLKVVDAAVEK 55 + ++++ +L +P + I GDGIG VT A+ +V++A Sbjct: 8 IFNRLLANPPSPFTSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAP 67 Query: 56 AYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN 115 + + +V G +P E ++ ++ +V +KG L TPVGGG+ SLN Sbjct: 68 VHF--------------ERYEVLGNMRKVPEEVIESVKRNKVCLKGGLATPVGGGVSSLN 113 Query: 116 VALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKV 175 + LR+ELD++ L G V E D+V+ REN+E Y+G+E + E Sbjct: 114 MQLRKELDIFASLVNCINVPGL---VTRHENVDIVVIRENTEGEYSGLEHEVVPGVVE-- 168 Query: 176 IKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMK 235 +K ++ ++R+ R A EYA N+R VT VHK NIMK Sbjct: 169 ---------------------SLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMK 207 Query: 236 FTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAE 295 +G F + ++A+ G I ++I D Q++ +P + Sbjct: 208 LADGLFLESCREVAKHYSG--------------------ITYNEIIVDNCCMQLVAKPEQ 247 Query: 296 YDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTA----PKYAGQDKV 351 +DV+ NL G+ I++ A GG G+ PG N+G E A+FE K Q K Sbjct: 248 FDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKA 307 Query: 352 NPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDA 411 NP +++LS+ MMLRH+ + AD + ++ I R D E DA Sbjct: 308 NPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGK-----YRTKDLGGDCTTQEVVDA 362 Query: 412 IIENM 416 +I + Sbjct: 363 VIAAL 367 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 130/394 (32%), Positives = 187/394 (47%), Gaps = 31/394 (7%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G ++ A V+D A KI W G+++ + L Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAA---RLSGFKIDWDVHQAGQRALAE--SESLL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQ-GTPSPVKH 143 P TL+ IR A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR + Sbjct: 57 PDATLNSIRTNGAALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLPIASTQEEPE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+V+ REN+ED+YAG+E+ S A V++ L G P + +KP + Sbjct: 117 RPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTP 172 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R+V A +A + R V V TEG F ++A Sbjct: 173 HGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAAR------------ 220 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 I + V A ++ P +DV+ NL GD ISD AA VG +G+A Sbjct: 221 --------HPSIASRTVPVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVA 272 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 PGANIG A+FEATHG+AP++AG ++NP ++I S M+L H+G E A I +E Sbjct: 273 PGANIGAHHAVFEATHGSAPEFAGSGRLNPTALIFSGCMLLDHLGEHETAARIRAAVEDV 332 Query: 384 INAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A +T+D A EF A+ + + Sbjct: 333 VAAGEVLTFDLLAPQRSADAATTVEFTRAVTDRL 366 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 105/402 (26%), Positives = 167/402 (41%), Gaps = 66/402 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V LKV++ +K + + + G + +G+ LP E Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKK---TGKTFEKVFGHIGGDAIDRFGEP--LPEE 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGTP-- 138 T + E G + P +ALR+ L+LY +RP++ Y+ Sbjct: 57 TKKICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHV 116 Query: 139 SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K D+V RE S +Y G E G Sbjct: 117 SPLKEKVIGSGVDLVTVRELSYGVYYGQPR-----------------------GLDEEKG 153 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + +R+ R A E A N R VT V K N++ ++ ++ ++ARE Sbjct: 154 FDTMIYDRKTVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREY--- 208 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + D Q++L+P+++DVI N+ GD +SD AA Sbjct: 209 -----------------PDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAA 251 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A+ GD+ L+E G+AP AG++ NP + ILS MML H G E A Sbjct: 252 LPGSLGLLPSASFGDKN-LYEPAGGSAPDIAGKNIANPIAQILSLAMMLEHSFGMVEEAR 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +E I T D + K + S+ GD I + + Sbjct: 311 KIERAVELVIEEGYRTRDIAEDPE--KAVSTSQMGDLICKKL 350 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 111/392 (28%), Positives = 172/392 (43%), Gaps = 64/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V A + V+D + ++ G++ + +G L Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDEL-------DVDFDYIYGIAGDECNEEHGTP--L 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ET+D++R+ + G + V +RQE+ ++ LRPV+ Y T S Sbjct: 60 PQETIDIVRDSDACLFGAAG----ETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E D +I REN+E +Y + E I + + E Sbjct: 113 ENVDFMIVRENTEGLYIA-----------------------DQEEETEDGAIAKRVITRE 149 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R++ A +YA N+R VT VHK N++K T+G FK Y++ + Sbjct: 150 AEERIIDYAFQYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKY------------ 197 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I +D DA ++ +P E+ V+ NL GD +SD A VGG+G+ P Sbjct: 198 --------PDIDTEDFYVDATAMYLVTQPQEFQVVVTTNLFGDILSDEGAGLVGGLGLIP 249 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG + ALFE HG+AP AGQ K NP +++LSA MMLR++G +AAD + + Sbjct: 250 SANIGADGALFEPVHGSAPDIAGQQKANPIAMMLSAIMMLRYLGENDAADKFDAAILKVL 309 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D E A+ + Sbjct: 310 SEGK-----TLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 95/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 10 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEED- 61 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 62 -----IRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 116 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 117 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 150 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 151 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 205 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 206 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 250 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 251 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 310 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE II ++ Sbjct: 311 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDIIRHI 345 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 93/403 (23%), Positives = 153/403 (37%), Gaps = 60/403 (14%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V KV++ K + +I+ + G + +G LP Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASK---FDFEITTQDYDIGGAAIDNHGN--ALPDS 57 Query: 88 TLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGTPSP 140 T+ E + G + P R + LR DL+ +RP S Sbjct: 58 TMAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSL 117 Query: 141 VK-----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 + D+++ RE + DIY G E G Sbjct: 118 STLRSDISEQGFDVLVIRELTGDIYFGEPKGRRGEG-------------------EEETG 158 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 S KR+ A + A + + VT V K N++ T ++ ++A E Sbjct: 159 FDSMFYSRREVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEY--- 213 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ ++ + D Q++ P ++DV+ C NL GD +SD A Sbjct: 214 -----------------PDVELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAM 256 Query: 316 QVGGIGIAPGANIG-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAA 373 G +G+ P A++ D ++E G+AP AG NP + ILSA +MLR+ + AA Sbjct: 257 ITGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAA 316 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + A++ +T D + SE GD I + + Sbjct: 317 KAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 106/399 (26%), Positives = 183/399 (45%), Gaps = 56/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +V PA +V++ K +++++Y G ++ Q G+ L Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKH---GLSFNFIDLYAGFQTFQETGK--AL 76 Query: 85 PAETLDLIRE-YRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P ET+ +++E + A+ G + +P G S VALR+E+ L+ +RPV+ +G Sbjct: 77 PDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + DMVI REN+ED+Y IE K Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYID------------------KATGTRVADATKRI 173 Query: 202 SEEGTKRLVRAAIEYAIAN----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 SE T+R+ A++ A+ + ++T+ HK N++ ++G F++ ++ Sbjct: 174 SEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYE------- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 N + +I + I D+ + ++ P +DVI NL GD +SD AA V Sbjct: 227 ---------SNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALV 277 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G +G+ P AN+G E + E HG+AP AG+ NP + I S +ML +G EAA I Sbjct: 278 GSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIY 337 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ + ++ + D + D ++ + Sbjct: 338 KAVDANLREGSI-----KTPDLGGKASTQQVVDDVLSRL 371 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 94/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 48 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEED- 99 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 100 -----IRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 154 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 155 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 188 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 189 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 243 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 244 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 288 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 289 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 348 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE +I ++ Sbjct: 349 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDVIRHI 383 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 127/397 (31%), Positives = 183/397 (46%), Gaps = 59/397 (14%) Query: 23 VPENPII--PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG ++ +++ V+DA W Y G + G Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGD 59 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP ET+ I ++A+KGPLTTP GGG RS+NV LR+E +L+ +RP P Sbjct: 60 P--LPRETIQSIHHNKLALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IP 113 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D+ + REN + YA E D P + Sbjct: 114 GGRFENVDITLIRENLDGFYAAFEHYMPIGD------------------DPHAVAMCAGF 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G R++R A EYA+ N R VTLVHK NI+K G F + G ++A+E Sbjct: 156 NTRTGCHRIIRYAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I ++ I DA Q++L P +DVI NL GD +SD +A +GG+ Sbjct: 208 -----------EGRIAFEERIVDACAMQLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGL 256 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+APG NIG + A+FEA HG+AP AG+ NP +++L+A MML H+G T+ A + + Sbjct: 257 GLAPGGNIGKQAAIFEAVHGSAPDIAGKGIANPLALMLAAAMMLDHVGKTDLATRLRNAI 316 Query: 381 E-GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D K E A+I + Sbjct: 317 RITTLEDGIRTPDL------GGTAKTRELTQALISRI 347 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 98/399 (24%), Positives = 165/399 (41%), Gaps = 62/399 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ A+ + + + E+ + Sbjct: 45 ARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHI-------GVPVDFEELNLSGLDIKDEDS 97 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTP 138 + E + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + G Sbjct: 98 YLGAFNEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQ 157 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + D+VI R+N+E Y+ +E + S E + Sbjct: 158 T---RHNNVDLVIIRQNTEGEYSHLEHENVSGVIE-----------------------NL 191 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K +EE ++ + A ++A +DR VT VHK NIMK +G F +++ Sbjct: 192 KVTTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSY------ 245 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 I +I D Q++ P ++DV+ NL G+ +S+ A+ VG Sbjct: 246 --------------PNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVSNIGASLVG 291 Query: 319 GIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G GI PG NIG + A+FE+ + T G+D NP S++ ++ +ML H+ +T ADLI Sbjct: 292 GPGIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLEHLEFTAYADLIN 351 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + +T D ++F A+ + Sbjct: 352 SAILKVVQRGVLTADV------GGSHTTTQFLSALKSEL 384 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 334 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 116/413 (28%), Positives = 187/413 (45%), Gaps = 48/413 (11%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE----KSTQ 76 + + Y+ GD G D+ L V+ + + I W+ G KS Sbjct: 9 KERKDRYKVCYMPGDDSGFDMMEGALVVLLSM-------DLPIDWVRADLGWCMWEKSVN 61 Query: 77 VYGQDV----WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPV 131 +GQ +P ET+D IR + +T+ G G +S + +RQ DLYI LRP Sbjct: 62 KFGQGDPRCNTVPPETIDKIRSSDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPA 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + SP+K D+V+FREN+ED+Y+ +E+ + + K G+++ R Sbjct: 122 KTLPDLGSPLKGDPKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHK------GMERFRKM 175 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + + S G +R++RAA EYA + R V +K N+++ T+G K ++A+E Sbjct: 176 GDVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKE 235 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 I + ADA ++ P +Y VI N+ GD +SD Sbjct: 236 YEQY------------------GITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSD 277 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG+G AP NIG+ A+FE G+ PKYA Q +VNP +++L+++MML ++G + Sbjct: 278 EASQLTGGLGFAPSGNIGENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLGLDQ 337 Query: 372 AADLIVKGMEGAINA---KTVTYDFERLMDG-----AKLLKCSEFGDAIIENM 416 A I + + KT+TYD R E AI + + Sbjct: 338 AGQKIEWAINEVLKENRPKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 334 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 102/399 (25%), Positives = 154/399 (38%), Gaps = 58/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDG+G +V A KV+ A E G S+ +G+ + Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAE--VHGGLSFSFTAFPWSCDYYLEHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + + ++ G + P + L + +R+EL+L I +RP + G SP Sbjct: 60 PEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSP 119 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + HP D V+ RENSE Y+ + + + I Sbjct: 120 LLHPNDFDFVVIRENSEGEYSEVGGRIHRG--------------------DDEIAIQNAV 159 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + T+R++R A E A R VT K N + + + Q A + G Sbjct: 160 FTRKATERVMRFAFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSG------ 212 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I DA + RP +DVI NL GD ++D ++ +G I Sbjct: 213 --------------IETSSQHIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSI 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GIAP ANI ++FE HG+AP AGQ NP I +A++ML H G E I+ Sbjct: 259 GIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ME T D +E D I + Sbjct: 319 DVMEQVTADGIKTRDI------GGQSTTAEVTDEICSRL 351 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 108/391 (27%), Positives = 165/391 (42%), Gaps = 53/391 (13%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDG+G ++ A+L ++ A +S + G + + Sbjct: 7 SVPITVAYGDGVGPEIMEAVLFILKEARA-------DVSIETVDIGHNQYKKE-WTSGIA 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 + I R+ +K P TP G G +SLNVALRQ L LY+ +RP Y P Sbjct: 59 PSAWESISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPVVGTKHP 116 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI REN ED Y+G+E + E +K + Sbjct: 117 DLDVVIIRENEEDTYSGVEH-----------------------KLSEDTHECVKISTRSA 153 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 ++++ A YA A++R VT K NIMK T+G ++A+ Sbjct: 154 SEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGY------------- 200 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 +I I D + +I P ++DV+ NL GD +SD ++ G IG+ Sbjct: 201 -------PDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVSLSSGSIGLTGS 253 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIGD A+FEA HG+AP AG++ NP ++ +A ML H+G + A +I + Sbjct: 254 ANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQLDKAGVIRNAFLKTLE 313 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + EF AI+ N+ Sbjct: 314 DGVHTADIYSEKTSLRRASTMEFAQAIVGNL 344 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 95/407 (23%), Positives = 160/407 (39%), Gaps = 66/407 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVWL 84 + I I GDGIG++V P ++V++AA K + + +G+ + Sbjct: 5 SFRIAAIPGDGIGLEVLPEGIRVLEAAALKH---GLALEFDTFEWASCDYYLQHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + +++Y G + P + + R+E D Y+ +RPVR + G P Sbjct: 60 PDDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCA 119 Query: 141 VKHPE--LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + + D V+ REN+E Y+ + G+ I Sbjct: 120 LANRKVGDIDFVVVRENTEGEYSSLG-------------------GIMFENTENEIVIQE 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 + G R+++ A + A +R VT K N M + + +A Sbjct: 161 SIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHY------ 214 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA-CMNLNGDYISDALAAQV 317 + D + +L+P +DV+ NL GD +SD A Sbjct: 215 --------------PHVSWDKQHIDILCARFVLQPERFDVVVVASNLFGDILSDLGPACA 260 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE--- 371 G IGIAP AN+ E +LFE HG+AP G++ NP ++I S +ML +G + Sbjct: 261 GTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDERY 320 Query: 372 --AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A D ++ +E I +VT D L + G AI + + Sbjct: 321 QRAHDDMLNAIERVIADGSVTPDM------GGTLSTQQVGAAISDTL 361 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 333 bits (854), Expect = 8e-90, Method: Composition-based stats. Identities = 99/402 (24%), Positives = 162/402 (40%), Gaps = 59/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG ++T + ++V++ EK +S+ G + +G LP Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEK---FGLGLSYTYKDAGGTAYDKFGTP--LP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP- 138 +T++ + + G + + LR+ L LY LRPV+ Sbjct: 57 DDTIEACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVE 116 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K + D+VI RE IY G + +++ Sbjct: 117 YSPLKPELVKGVDLVIVRELIGGIYFGDKCESEQH-------------------NGAERA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 ++ S R+ + A E A R VT V K N++ T ++ ++A Sbjct: 158 WDLENYSVPEVDRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESY--- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + ++ D Q+ +RP ++DVI NL GD +SD A Sbjct: 213 -----------------PDVELNNLYVDNCAMQLAIRPTQFDVIVTGNLFGDILSDEAAV 255 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G IG+ P A+IG +L+E HG+AP AG+ NP ILSA M+LR+ + AA Sbjct: 256 VGGSIGMMPSASIGTSTSLYEPIHGSAPDIAGKGIANPMGTILSAAMLLRYSLHEEAAAK 315 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I ++ A+ T D +G + E I E + Sbjct: 316 AIEAAVDKALADGYRTPDL--WKEGFQKANTEEITKVICERI 355 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 333 bits (853), Expect = 9e-90, Method: Composition-based stats. Identities = 98/405 (24%), Positives = 160/405 (39%), Gaps = 59/405 (14%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + I + GDGIG +V V+ A + + E+ G + + G V Sbjct: 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAG---SLEGLEFDFKEMPVGGAALDLVG--VP 98 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQ-- 135 LP ET + + G + LR++L ++ LRP Sbjct: 99 LPEETFTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQL 158 Query: 136 --GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 + + E DM+I RE + IY G G+ E Sbjct: 159 VDASTLKKEVAEGVDMMIVRELTGGIYFGEPR------------------GITINENGEE 200 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 G+ + + R+ R A E A R + V K N++ + ++ LA E Sbjct: 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEY- 257 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 ++ + + D Q++ P ++D I N+ GD +SD Sbjct: 258 -------------------PDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEA 298 Query: 314 AAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 + G IG+ P A++G+ LFE HG+AP AGQDK NP + ILSA M+L++ +G + Sbjct: 299 SMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEK 358 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I + A+N T D G KL+ C E G+ +++++ Sbjct: 359 AAKRIEDAVVDALNKGFRTGDIYSP--GNKLVGCKEMGEEVLKSV 401 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 333 bits (853), Expect = 1e-89, Method: Composition-based stats. Identities = 98/407 (24%), Positives = 158/407 (38%), Gaps = 66/407 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVW 83 + I I GDGIGV+V P L+ +DA + + ++ I +GQ Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRR---FGLRFAYEPIEWASCDYYAKHGQ--M 93 Query: 84 LPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + G + P + + R+E D Y+ LRP R + G P Sbjct: 94 MPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 153 Query: 140 PV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ + D +I REN+E Y+ + G + Sbjct: 154 PLAGRKAGDIDFMIVRENTEGEYSAVG-------------------GTMFEGTEREFVVQ 194 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + GT+R+++ A E A +T+ K N + + + ++A Sbjct: 195 QAVFTRHGTERVLKFAFELAQRRA-KRLTVATKSNGIAISMPWWDARAAEMAARY----- 248 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ D + +++P +DV+ NL GD +SD A Sbjct: 249 ---------------PDVAWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACT 293 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----W 369 G IGIAP AN+ E +LFE HG+AP AG+ NP ++I SA MM+ +G Sbjct: 294 GTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPA 353 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EA D IV +E + T D E GDAI+ ++ Sbjct: 354 REAHDAIVAAIEHVLKHGPRTRDM------GGRASTREVGDAIVAHL 394 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 155/400 (38%), Gaps = 68/400 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG +VT A LKV+ A E +++ G + +G+ P Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDE---AEGLGLAYEVFPFGGAAIDAFGEP--FPEP 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP--S 139 T + E + G + P G + ++LR+ DL+ LRP + + G S Sbjct: 57 TRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLS 116 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K D++I RE + IY G A+ Sbjct: 117 PLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAE-----------------------AWN 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + S+ +R+ R A E A R V V K N+++ E ++ ++ R Sbjct: 154 TERYSKPEVERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ ++ DA ++ PA +DV+ N+ GD +SD + Sbjct: 207 ---------------PDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLP 251 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLI 376 G +G+ P A++G +FE HG+AP AG+ NP + ILSA MML H G E A + Sbjct: 252 GSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKV 311 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ D F ++ ++ Sbjct: 312 EDAVAKALLE-------TPPPDLGGSAGTEAFTATVLRHL 344 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 330 bits (846), Expect = 6e-89, Method: Composition-based stats. Identities = 99/398 (24%), Positives = 168/398 (42%), Gaps = 67/398 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + GDG+G ++ + +V I + E+ ++S Sbjct: 62 KACYGGRHTVAMLLGDGVGPELLSYVKEVFQVI-------GAPIDFEEVAVNQESEDATF 114 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + L ++ V IKG T G S NVALR L+LY ++ R + G Sbjct: 115 T------DALLAMKRNGVGIKGNFAT--EPGQSSRNVALRLNLNLYAFVQRCRNFPGV-- 164 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V + D+VI REN+E Y+ +E + E +K Sbjct: 165 -VTRHQNVDIVIIRENTEGEYSRLEHENVPGVVE-----------------------SLK 200 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + E + R+ + A +YA+ ++R VT VHK NIMK +G F D +A+ Sbjct: 201 IITREKSTRIAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY------- 253 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I +I D Q++ +P ++DVI NL G+ + + A VGG Sbjct: 254 -------------PQIEFNHMIIDNTCMQLVTKPQQFDVIVLPNLYGNIVGNVAAGLVGG 300 Query: 320 IGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ G N+G + ALFE T + AG++ NP ++L++ ML ++G + A LI Sbjct: 301 AGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGMLLTSADMLEYLGHIKEAKLIRD 360 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I + + R D K S+ +A+++++ Sbjct: 361 SVVDVIGEQKI-----RTADLGGSFKTSKVIEAVLKSL 393 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 330 bits (845), Expect = 8e-89, Method: Composition-based stats. Identities = 100/402 (24%), Positives = 176/402 (43%), Gaps = 41/402 (10%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + +P I GDGIG +V KV+ AA E + W+++ G+ + Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQE---VYNFDVEWIDMPFSADHYVKTGE--TIS 57 Query: 86 AETLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +L + +YR G + G + + + +R D Y+ LRPV+ +G +P+ Sbjct: 58 ESSLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPL 117 Query: 142 K--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCG 195 K D + REN+ED Y GI ++ +++ ++ +R+ + G+ + Sbjct: 118 KGKTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIA 177 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + S+EG KR++ + + A + + ++ V K N++ G +++ A + Sbjct: 178 YQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKY--- 234 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ DA + P +DV+ N+ GD I+D A Sbjct: 235 -----------------PDVKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAM 277 Query: 316 QVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+APG NI E ++FE G+APKY G +KVNP + I + M+L H+G +AA Sbjct: 278 IQGGLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGEKQAAA 337 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 IV +E + K + R D S+ G I + Sbjct: 338 GIVDAIEQNLKEKKI-----RTYDLGGSAGTSDVGTDIARIV 374 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 329 bits (844), Expect = 9e-89, Method: Composition-based stats. Identities = 135/393 (34%), Positives = 199/393 (50%), Gaps = 34/393 (8%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDG G ++ A V+D A + W G+ + + G+ L Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAA---GSAGFHLDWDVRPAGQGALRSVGE--LL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 PA TLD IR VA+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + Sbjct: 57 PASTLDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAV---D 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+Y+G+E+ ADS A V L E +KP + Sbjct: 114 SGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHA-----DPGIAFSLKPITPG 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G++R+V A+++A N R V + TEG F + +L E Sbjct: 169 GSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEY------------ 216 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +IV V ++ PA+ DV+ NL GD ISD AA VGG+G+AP Sbjct: 217 --------PDIVTATVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAP 268 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 GANIGD A+FEATHG+AP++AG +++NP ++ILS M+L H+G A I + + Sbjct: 269 GANIGDRTAVFEATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRSVL 328 Query: 385 NAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT+D A+ + + + +A+IE + Sbjct: 329 EEGRSVTFDLLPPDRAARAVTTTAYAEAVIERL 361 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 103/401 (25%), Positives = 158/401 (39%), Gaps = 61/401 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + I GDGIGVDVT +KV+D+A +I W E + G Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA------TGGRIEWTEFDYSCERYAKTG--A 52 Query: 83 WLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + + G + P + L + LR+ + Y+ LRPVR G S Sbjct: 53 MMPPDAPTTLAGFDAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIAS 112 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ E MVI REN+E Y+ I GV + Sbjct: 113 PLAGVSDEALSMVIVRENTEGEYSPIG-------------------GVHNRGNQNEFALQ 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G +R++R A E A + V K N + + + ++A E Sbjct: 154 ESVFTRIGCERIIRYAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEY----- 207 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + DA +++ PA DVI NL GD +SD AA Sbjct: 208 ---------------PQTPSVSMHVDALAARMVSDPASLDVIVASNLFGDILSDLAAAIT 252 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+A NI E ++FE+ HG+AP AGQ NP + IL+ M+L H+ A+ Sbjct: 253 GGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQILAGAMLLDHLNEPATAN 312 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 I ++ ++ V R D + G AI E Sbjct: 313 KIRLAVDQVLSDGRV-----RTPDLGGTATTEQLGTAIAEA 348 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 97/398 (24%), Positives = 176/398 (44%), Gaps = 65/398 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDG+G ++T ++ + +A I W I + + + Sbjct: 23 KKYGGRFTVTLIPGDGVGKEITDSVRTIFEA-------ENIPIDWETINIKQT---DHKE 72 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPS 139 V+ E ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + Sbjct: 73 GVY---EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT 129 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D+++ REN+E ++G+E ++ E +K Sbjct: 130 RI---PDIDLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLK 163 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 164 VMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY------ 217 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q + +P ++DV+ ++ G + + AA +GG Sbjct: 218 -------------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ GAN G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K Sbjct: 265 PGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISK 324 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I T D ++F + II + Sbjct: 325 AVHETIAEGKHT-----TRDIGGSSSTTDFTNEIINKL 357 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 327 bits (837), Expect = 7e-88, Method: Composition-based stats. Identities = 84/397 (21%), Positives = 149/397 (37%), Gaps = 64/397 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDG+G +V + +V+ + Y G + + GQ LP Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVE---RLYGHHFHLQDEYFGGVAIDLTGQP--LPQR 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTP--SPV 141 TL + G + P +ALR+ L ++ +RPV T SP+ Sbjct: 59 TLAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPL 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 K+ + D V+ RE + IY + E Sbjct: 119 KNADEIDFVVVRELTGGIYFSYPKER-----------------------TEEVATDTLTY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +R+V A + A + VT + K N+++ + ++ ++A Sbjct: 156 HRHEIERIVSYAFQLANKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRY--------- 204 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 + ++ ++ DA +++ P +DVI NL GD +SD + G +G Sbjct: 205 -----------PNVEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLG 253 Query: 322 IAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKG 379 + P A+ + +L+E HG+AP AG++K NP +++ S MML G T I + Sbjct: 254 MLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEEA 313 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D + F A+I+ M Sbjct: 314 VSAVLKSGKCTADI------GGTETTTSFTKAVIQEM 344 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 107/414 (25%), Positives = 172/414 (41%), Gaps = 70/414 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P++ + + + GDGIG ++ + K+ A + Sbjct: 30 IQSPSKNQFAR-------YGGRHTVTLLPGDGIGPEMLDIVQKIFTFA-------NVPVD 75 Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELD 123 + E K T + I+ VAIKG + T +S NV LR+ LD Sbjct: 76 FEECQLDSKPT----SPESDLDNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLD 131 Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 L+ + P+ + ++V+ REN+E Y+G E + + E Sbjct: 132 LFANVLHCVSIPTIPT---RHKGINIVMIRENTEGEYSGHEHETVNGVVE---------- 178 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 +K C+ E +R+ R A +YAIA++R +T VHK NI K +G F Sbjct: 179 -------------SLKICTREKLERISRFAFDYAIAHNRKKITAVHKANIQKLADGLFLK 225 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++A +E+ I +I D Q++ RP ++D++ N Sbjct: 226 VVGEIAEKEY-------------------PSITFDSMIVDNASMQLVSRPQQFDIMLMPN 266 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEM 362 L G+ IS+ VGG G+ G NIGD+ A+FE T T AGQD NP + I + Sbjct: 267 LYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTAFIRAGVD 326 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ML ++G TE A+LI + AI K + D K S+ +A++ N+ Sbjct: 327 MLHYLGLTEYANLISDALFDAIVIKRL-----HTKDIGGTAKTSDVVNAVMRNI 375 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 326 bits (836), Expect = 9e-88, Method: Composition-based stats. Identities = 96/397 (24%), Positives = 167/397 (42%), Gaps = 62/397 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I DGIG + +++V + + E Y + + + Sbjct: 40 ATYGGRHTVSLIPADGIGQSLIMGIVEVFQ-------NSGVPVDFEECYITGDTNEEKMK 92 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + + A+KG T +G +S NV LR +LDLY + + Y + Sbjct: 93 SF---NDIKTSVLRNGTALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSYP---TV 146 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+++ REN+E Y +E + E IK Sbjct: 147 ITRHNNVDLIVIRENTEGEYTNLEHENIPGVIEM-----------------------IKI 183 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +++ ++R+ + A +YA+ N+R VT VHK NIMK ++G F ++A Sbjct: 184 ITKKKSERIAKYAFDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGY-------- 235 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 EI D+I D Q++ +P ++DVI NL G+ +S+ AA VGG Sbjct: 236 ------------PEIDFNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAALVGGP 283 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ G N G+ +FE+ T + A ++ NP S++ +A +LRH+ ++ A LI Sbjct: 284 GLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSMLFAATALLRHLQLSKHAQLIESC 343 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + K VT + R +D SEF + +++ + Sbjct: 344 I-----HKIVTTNQARTVDIGGNTSTSEFFEILVKEV 375 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 95/398 (23%), Positives = 158/398 (39%), Gaps = 56/398 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I GDGIG +V A + + AA+E ++ G + G + Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAM 60 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P + DL+++ + G + P L + LRQ+LDL + LRPVR + G P+ V Sbjct: 61 PPDAADLVKKTDAVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKV 120 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + D+VI REN+E Y G GV GI + Sbjct: 121 RDTDGVDLVIVRENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVH 161 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S +R A A + LV K N M++ + ++ + Sbjct: 162 SRRAIERAAHQAFALAGRRS-GRLCLVTKSNAMRYGYPLWDRVVREVGEQY--------- 211 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 + ++ V+ DA +++ P DV+ NL GD +SD A GG+G Sbjct: 212 -----------PGVELETVLVDAMAARMIQAPRSLDVLLASNLFGDILSDLAAVLAGGMG 260 Query: 322 IAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 +AP AN+ + ++E HG+AP AG+ NP + +LS M+L +G T+AA + Sbjct: 261 MAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLLSGAMLLEDLGHTDAARRVRD 320 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D ++ A++ M Sbjct: 321 AVADTLRDTRH-----HTADLGGNATTADVASAVLHTM 353 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 96/400 (24%), Positives = 173/400 (43%), Gaps = 60/400 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I IEGDGIG +V +K +++ + + S+ + G K+ + +G +P Sbjct: 2 KKNIVVIEGDGIGPEVIKQAIKALNSIGNR---FHHEFSYQNVLAGAKAIETFGDP--MP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-P 138 ET+D + + G + P + LR+E+DLY +RP+ Y G Sbjct: 57 KETIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINK 116 Query: 139 SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP+K E + VI+RE + IY G + ++ + Sbjct: 117 SPIKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE----------------------AY 154 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 SE+ +R+ + + A + +R +TLV K N+++ T +++ ++A + Sbjct: 155 DYCVYSEKEIERIGEMSFKAARSRNR-KMTLVDKANVLE-TSRLWREVIQKMALDYS--- 209 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D QIL+ P ++DVI N+ GD +SD + Sbjct: 210 -----------------DVDLEFLYIDNAAMQILINPRKFDVILTDNMFGDILSDEASIL 252 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+ P A+IG + +LFE HG+ P+ G++ NP ILS MML + + +L+ Sbjct: 253 TSSLGLLPSASIGSKKSLFEPIHGSYPQAKGKNIANPLGCILSVSMMLEYFEMPQEKNLL 312 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ +I K T D D E GD I + + Sbjct: 313 EEAVKSSIQEKICTPDIIL--DDRNSSSTEEVGDYIEKYI 350 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 152/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG DVT A +V+ + ++ + G + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHS---GFTLTATPFPWSCAFYKETG--AMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PPDGIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + A + + Sbjct: 117 LK-AEGFDILCIRENTEGEYSGAGGRVHQGTA-------------------DEVAVETSI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R + A R + V K N K++ + + +LA E Sbjct: 157 FTRTGVERILRFGFDQARQR-RRKLASVTKSNAQKYSMVLWDEITRELAAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+ NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVVASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G AA ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLDHLGQARAARKVI 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E T + A++ + Sbjct: 316 EALERTTARGIGTVP--------GKNRTETITAAVLAAL 346 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 106/412 (25%), Positives = 169/412 (41%), Gaps = 73/412 (17%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 + + + +GDGIG ++ A + ++A I W ++ G ++ Q Sbjct: 26 QRAQSTQAHTVLTFDGDGIGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNT 78 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPV----------GGGIRSLNVALRQELDLYICL 128 G V++ +D E V KGPLT P G S N R+ L+ + Sbjct: 79 G--VYIDDSHMDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANV 136 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RPVR G +P D+V+ REN+ED+Y G E Sbjct: 137 RPVRSMPGVRAPF---NDVDLVVIRENTEDVYTGEETWV--------------------- 172 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S ++R+ + +YA N R VT +HK N+ K ++G F + ++ Sbjct: 173 --DADTVHCVKRISRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHER 230 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A I+ D +AD+ L ++++ P +DV+ C NL GD Sbjct: 231 AA------------------ATDLGGIIADDQLADSCLTKLMIEPKSFDVLCCPNLYGDL 272 Query: 309 ISDALA----AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 ++ VG +G+ P NIG ALFE HG+AP AG+ NP S ILS MML Sbjct: 273 VNPLSLRINRGMVGSLGLCPSGNIGTHQALFEPAHGSAPDIAGKGIANPTSQILSGCMML 332 Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G EA+ + + + V +D E A+++++ Sbjct: 333 SHLGEFEASQRLENALRAMYASGIV------PVDFGGQADTKEVVAAVLKHL 378 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 69/398 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + V+ I + I ++S Sbjct: 82 SQYGGRYTVTLIPGDGIGPEMARHVKTVLHKC-------GAPIDFEVIDIKDES------ 128 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ++ + +KG +TT +S+N +R++LDLY + P + G Sbjct: 129 ---STDAAIISLKRNGIGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGV-- 183 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+V+ REN+E Y +E + E +K Sbjct: 184 -WTRHGQVDLVVIRENTEGEYGSLEHENVDGVVE-----------------------SLK 219 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E+ ++R+ + A +YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 220 IITEKKSRRIAKFAFDYALQNNRRKVTAIHKANIMKLADGLFLETCREISKDYT------ 273 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q++ P ++DV+ NL G+ +S VGG Sbjct: 274 --------------DIEFESMIIDNCCMQMVTNPQQFDVMVMPNLYGNIVSHIGIGLVGG 319 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 IG+ PG NIGD+ A+FE+ G ++ NP + ++ +MLRH+G + AD+I Sbjct: 320 IGLVPGKNIGDKYAIFESGARNIGSDLVGLNRANPCGFLFTSALMLRHLGLDDYADIIES 379 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I R D ++F DA+I+ + Sbjct: 380 AVRTTIKNGKC-----RTPDIQGDRTTADFIDAVIKEI 412 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 325 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 97/411 (23%), Positives = 170/411 (41%), Gaps = 66/411 (16%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 PA+ K TL K + + + G GIG ++ + + G+ + + Sbjct: 30 PARCSKRTLHR-KSKIGGRFFVTLLPGHGIGPEMMRHVEAIF-------ACGKVPVDFET 81 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYI 126 I G + + IR VA+KG + T + N+ LR +L+LY+ Sbjct: 82 IIVDAN----VGDASSM-DHAIKSIRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYV 136 Query: 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 + R + G + + D+V+ R+N+E Y+ +E + S E Sbjct: 137 NVVHCRNHPGINT---KHKGVDIVVIRQNTEGEYSCLEHEVTSGVVE------------- 180 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 +K + + ++ + EYA + R VT+VHK NIMK T+G F Sbjct: 181 ----------SLKIITWAKSFQIAKYCFEYARTHMRKKVTVVHKANIMKLTDGLFLKTCT 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++A+E +I + D+I D Q++ PA++DV+ NL G Sbjct: 231 EVAQEY--------------------PDIELNDIIIDNCCMQLVANPAQFDVMLVPNLYG 270 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + + + VGG G+ G N G E A+FE AT T G++ NP + + +A ML+ Sbjct: 271 NIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVATLYAAVDMLK 330 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+ + A +I + +E +N D D S+ + I++ + Sbjct: 331 HLELWDHAVVIRRAIEKTVNR-----DKVHTKDLGGDATTSKVVENILKEV 376 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 110/412 (26%), Positives = 165/412 (40%), Gaps = 78/412 (18%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG +V PA + V+ A + G + Q G+ LP Sbjct: 5 PYTILVIPGDGIGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALP 55 Query: 86 AETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + TL R + G + +P G RS V LR+ELDLY +RPV Sbjct: 56 SATLTAARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPR 115 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+V+ REN+ED+YAG E D I + + Sbjct: 116 RRKVDLVVVRENTEDVYAGRERVEDDGAT----------------------AIAERVITR 153 Query: 204 EGTKRLVRAAIEYAIAN---------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + R++R A + A A VT+VHK N+++ T G F+ ++A+ Sbjct: 154 RASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAY-- 211 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ I +++ D Q+ RP +DVI NL GD +SD Sbjct: 212 ------------------PDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVAC 253 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 A GG+G+AP AN+G+ ALFE HG AP AG+ NP + I ++L H+ AD Sbjct: 254 AWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPAD 313 Query: 375 ----------LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + + A T D ++ +A++ +M Sbjct: 314 LASAMRGWSARIQRAIRHVRAAGPHTPDL------GGSAVTTDITNAVLSHM 359 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 323 bits (829), Expect = 6e-87, Method: Composition-based stats. Identities = 102/409 (24%), Positives = 164/409 (40%), Gaps = 68/409 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V PA L++V+AA A G + G L Sbjct: 6 DTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQT--HNAGAQYYAESGD--AL 61 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA TLD R+ + G + P G + LR EL L+ +RP+R++ G P Sbjct: 62 PASTLDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 141 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + P E D V+ RE +E ++ + Sbjct: 122 LTDPRAEQIDFVLVREQTEGLFYARGRGEIR---------------------NDEEAYDT 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + GT+R+ A + A R +VT V K N+ + F+ ++A Sbjct: 161 MQITRSGTQRVTEFAFDIARQRKRRGKPGNVTCVDKANVF-QSMAFFRKVFDEVADR--- 216 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ DA ++ +P +DV+ N+ GD +SD A Sbjct: 217 -----------------HSDLTKDHAYVDALALNMVKKPWTFDVLVTENMFGDILSDLAA 259 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG------ 368 +GG+G+AP A+IGD+ LF+ HGTAP AG+ NP ++ LSA MML + Sbjct: 260 GLIGGMGMAPSADIGDKHGLFQPAHGTAPDIAGKGCANPSAMFLSAAMMLDWLAAKFGQP 319 Query: 369 -WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA L+ +E ++ K M+ C+E ++I ++ Sbjct: 320 TLADAARLMEGAVEHTLSTK-----LAIPMEYGGNANCAEMTRSVISSL 363 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 323 bits (827), Expect = 9e-87, Method: Composition-based stats. Identities = 108/416 (25%), Positives = 192/416 (46%), Gaps = 71/416 (17%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEK---AYKGERKISWMEIYTGEKS 74 N + + +I I DGIG +V PA ++V++AA+ K A + + + ++ + G ++ Sbjct: 23 NQQQIRLLSKVIGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWET 82 Query: 75 TQVYGQDVWLPAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPV 131 Q G+ LP ET++ ++ + AI G + +P G S VA+R+ +DLY +RP Sbjct: 83 FQKTGKS--LPVETVEALKNKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPC 140 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + + DM+I REN+E +Y E Sbjct: 141 QDL---------AKGIDMLIVRENTECLYIKKEKLTVDPT------------------TG 173 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDR---DSVTLVHKGNIMKFTEGAFKDWGYQL 248 E + + +E +KR+ A + A+ ++ VT+VHK N++ ++G F++ ++ Sbjct: 174 EKTAVADRLITERASKRIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEI 233 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 +++ ++ ++ + D+ + +++L P +YDV+ NL GD Sbjct: 234 SKKY--------------------PQVKTEEQLVDSMVYKMILDPTQYDVVVAPNLYGDI 273 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SDA +A VGG+G+ AN+ D AL E HG+AP G+ NP + I + M+LRH+ Sbjct: 274 LSDAGSAFVGGLGVTASANLSDSFALVEPVHGSAPDIFGKKISNPIATIRACAMLLRHLQ 333 Query: 369 W--------TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + KTVT D DAII+N+ Sbjct: 334 EKDPKCSYLNEIADSMDRAVNVVMPDKTVT-----TPDLGGKGNTETLVDAIIKNL 384 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 104/397 (26%), Positives = 170/397 (42%), Gaps = 62/397 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIGV+V K+ + I + G + G+ +P Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGK--VVP 60 Query: 86 AETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +D +++Y + G L P + +RQ+LD ++CLRP +++ G P+P+K Sbjct: 61 IDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLK 120 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+++ RENSE Y+ I G+ K P+ I + Sbjct: 121 KCE-IDILVVRENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHT 160 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R A E + R+ VTL K N MK+ + +A E Sbjct: 161 RRGLERVIRYAFEASRKR-RNHVTLATKSNAMKYGMVLWDSVFEAIAMEY---------- 209 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + DA +I+ P+++DVI NL D ISD G +GI Sbjct: 210 ----------PDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDIISDLTVTVAGSMGI 259 Query: 323 APGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 AP ANI E +LFE HG+A AG+ +P + ++ MML +G++E + LI + Sbjct: 260 APSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASSMMLEFLGYSEESVLIEEA 319 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +I K T D +E G+ I + + Sbjct: 320 IQSSILQKITTIDI------GGTKTTNEVGNFIADYI 350 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 89/401 (22%), Positives = 163/401 (40%), Gaps = 66/401 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG ++ L +++ K Y +I E G S +G+ L Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPS-- 139 +TL+ + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 EKTLNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLS 116 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G ++ + + Sbjct: 117 PLKAERVEGTDLVIVRELTSGIYFGEPRYFNNHE-----------------------ALD 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + E +R+V A + A + R +T V K N++ + ++ ++++ Sbjct: 154 SLTYTREEIERIVHVAFKLAASR-RGKLTSVDKENVL-ASSKLWRKVVNEVSQLY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ P ++DVI NL GD +SD + Sbjct: 207 ---------------PEVTVNHLLVDACSMHLITNPKQFDVIVYENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ ++ L+E HG+AP AG++ NP +ILS M LR + +AAD Sbjct: 252 GSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + I T D L ++ + + + + Sbjct: 312 LEQHIYNMIEHGQTTADL------GGKLNTTDIFEILSQKL 346 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 322 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 99/409 (24%), Positives = 160/409 (39%), Gaps = 63/409 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V + KV+ E G S +G + Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLN---SNKSLDFEIDEDLAGGCSYDKHGTP--I 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQG-T 137 E E + G + P + R +EL L+ LRP ++ Sbjct: 60 TDEVFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLV 119 Query: 138 PSPVKHPE---LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 + PE D++I RE + IY G G+K I E Sbjct: 120 DASTLKPEIVSGLDIMIVRELTGGIYFGEPR------------------GIKPIENGERK 161 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 GI + R+ + A + A + VT K N+M+ + +K+ +L +E+ Sbjct: 162 GINTHSYTTSEIVRVAKVAFDLARKRS-NRVTSCEKSNVMEAGQ-LWKEEVQELHDKEYK 219 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ + ++AD Q+L P ++DVI NL GD +SD + Sbjct: 220 -------------------DVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQAS 260 Query: 315 AQVGGIGIAPGANIGDEC------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++G + A++E HG+AP AG++ NP + ILS M LR+ + Sbjct: 261 MLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSL 320 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + K ++ +N T D G K + S GDAII + Sbjct: 321 DLDSEADALEKAVQDVLNDGLRTKDILSQ--GKKEVSTSAMGDAIISKL 367 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 100/394 (25%), Positives = 163/394 (41%), Gaps = 63/394 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDG+G +V K +DA I+W ++ G +G +PA+ Sbjct: 2 NVVLLPGDGVGPEVMAEARKALDALE-------LGIAWTDVPWGSAWWAEHG--TMMPAD 52 Query: 88 TLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--K 142 +D++R + + G + P + L + +RQELDL++ +RP R +G P P+ + Sbjct: 53 AIDVLRGHDAILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGR 112 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 P DMV RENSE YAG+ + F I + Sbjct: 113 APHDVDMVFVRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFT 153 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R A A A + + K N +F + + ++ E Sbjct: 154 RRGCERVIRYAFGMASAR-KGVLVNATKSNASRFGFPFWDEIVAEVGAEF---------- 202 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 +V+ ++ DA +++ P DV+ NL GD ++D AA GG+G+ Sbjct: 203 ----------PGVVVDRMLVDALSARLIRDPGSVDVVVASNLFGDILTDIAAALQGGMGM 252 Query: 323 APGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 A AN+ ALFE HG+AP AG+ NP I SA +ML +G E + ++ Sbjct: 253 AASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSAALMLEQLGAGEGSRRLMDA 312 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 +E T D +E GDA++ Sbjct: 313 LETVCRRGPRTRDV------GGTATTAEVGDAVV 340 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 320 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 106/399 (26%), Positives = 178/399 (44%), Gaps = 41/399 (10%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +VT +KV++AA + G + L Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAG---SLFGFSLELTHYPYGAEHYLST--RQVL 56 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P L+ + + G + P G R + + LR D Y +RPVR + TP P+ Sbjct: 57 PDHALEEMEGLDALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSF--TPGPL 114 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI----KFLREEMGVKKIRFPEHCGIG 197 + V+ REN+ED+Y GI D A + ++ + P+ + Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQY----- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + ++ DA +++ P ++ VI C N+ GD +SD LA Sbjct: 227 ---------------ESVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIG 271 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP N+GD ++FE HG+AP AGQD+ NP + ILS M+LRH+G T AA + Sbjct: 272 GGMGLAPSGNVGDRLSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETSAAKAME 331 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ ++ E ++ L GDA++ + Sbjct: 332 DAVQRYLS----GPVEELPIEMGGRLGTRGAGDAVVRRL 366 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 94/405 (23%), Positives = 161/405 (39%), Gaps = 57/405 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG++V A L V+ A + G + + G+ +P Sbjct: 7 RKRICVLPGDGIGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGE--TVP 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR---------------SLNVALRQELDLYICLRP 130 A T +++ + G +T+ S + LRQ LDLY +RP Sbjct: 58 ARTWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRP 117 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 V G V+ REN+E +YAG+++ +++ + Sbjct: 118 VTDMTG-------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + + ++ + G R+ A EYA N VT V K +++ + + A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ DA ++ RP + VI N+ GD +S Sbjct: 231 RY--------------------PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILS 270 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370 D A +GG+G AP N G+ A FE HG+AP +AG +K NPG++ ++ +ML H+G+ Sbjct: 271 DLGAGVMGGLGFAPSGNFGNSGAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFP 330 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + I + + T TYD ++ G+AI++ Sbjct: 331 TESACISQAVSLVSRTSTRTYDL------GGSHTTAQVGEAIVQQ 369 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 107/403 (26%), Positives = 175/403 (43%), Gaps = 61/403 (15%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + + + GDGIG ++ PA +K++DAAV A I+W E+ G + YG+ Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGAT--PIAWTELPLGRSAIDEYGEHT- 77 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPS 139 P +TLD + E + GP + + + +R+ L+ +RP + ++G + Sbjct: 78 -PTKTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNA 136 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V E TD+VI REN+E YA A + + I Sbjct: 137 IV---EGTDLVIVRENTEGFYADRNTFAGTGEM----------------MPTPDVAIMHG 177 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 178 IITRAATERIAHEAFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQY------- 229 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ I D DA ++ R ++DVI N+ GD +SD G Sbjct: 230 -------------PDVAINDFHIDAATVHLVRRADKFDVIVTENMFGDILSDLAGEVAGS 276 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EA 372 +GIAP N A+ +A+HG+AP AG+D NP ++ILS+ M+LR + A Sbjct: 277 LGIAPSINSSATHAMAQASHGSAPDIAGRDIANPIAMILSSAMLLRWLAAKFDDEKIARA 336 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD++ ++ + T D CS F DA++ Sbjct: 337 ADIVEAAVDLTVAEGATTPDM------GGTSSCSGFADAVVAA 373 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 116/422 (27%), Positives = 189/422 (44%), Gaps = 61/422 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P + + GDGIG V P ++V++A + +++ G + + LP Sbjct: 3 RPTVVTMPGDGIGNQVLPQAIRVLEAV-------GFEANYVHADIGWECW--CNEGNALP 53 Query: 86 AETLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRP 130 T+ L+R++++ + G +T+ G S V +RQ +L +C+RP Sbjct: 54 DRTIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRP 113 Query: 131 VRYYQGTPSPVKHP--------ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 + G P D+V+FR+N+E +YAG+EW + + ++ Sbjct: 114 CLSFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKF 173 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 E + ++ +++ +R+ AA ++A +VT+ K N+++ T G + Sbjct: 174 AAFANT-PGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMME 232 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + Q+ ++ EI + DA + P EY VI Sbjct: 233 EVAKQVQKQY--------------------PEIALWSTNIDAQTMWLTKNPEEYGVIVAS 272 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQD--KVNPGSIILSA 360 NL GD ISDA A VGG+G A NIGDE A+FE THG+APKYA + VNP ++ILSA Sbjct: 273 NLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSA 332 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGA-----KLLKCSEFGDAIIE 414 MML H+G +E AD I K + + TYD R+ G + DAI+ Sbjct: 333 AMMLDHIGESEKADRIRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILV 392 Query: 415 NM 416 ++ Sbjct: 393 HV 394 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 86/408 (21%), Positives = 153/408 (37%), Gaps = 62/408 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + N I + GDGIG + T + K+++ ++ + I E G + G Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQ---FQINIVTTEHKIGGDAINSEGTP- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQ 135 P TL + + G + P ++ +ALR+ +L+ LRP+ Sbjct: 57 -FPKSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLAD 115 Query: 136 GTP--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 SP+ P D++ RE + IY G Sbjct: 116 ELKELSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGL------------------ 157 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 +R+ A + A R V+ + K N++ T +++ LA+ Sbjct: 158 -NEYAFDTAVYHRFEIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAK 214 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ ++ + D Q++ P+++D+I C NL GD +S Sbjct: 215 NY--------------------PDVELEHLYIDNASMQLINNPSKFDIILCPNLFGDILS 254 Query: 311 DALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MG 368 D A G IG+ P A+I + L+E G+AP A ++ NP + ILS ++ R+ + Sbjct: 255 DECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIAHILSIALLFRYSLK 314 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I K + A+ T D + + K + +E GD I + Sbjct: 315 LDHIAIKIEKAVSQALMLGYRTIDIAKKHE--KSISTNEMGDIIAALI 360 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 89/406 (21%), Positives = 153/406 (37%), Gaps = 64/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + + KV+ E G + +GQ + Sbjct: 5 KLLLLPGDGIGPEAMAEVRKVIAFLNSDL---NLGFETEEGLVGGCAYDAHGQ--AISDA 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ + G + P + + LR+++ LY LRP Y Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 142 KHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 E D++I RE + +Y G + + + GI Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIID------------------LGNGQKRGID 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ A E A R+ VT + K N+MK + + Sbjct: 162 TQVYDTYEIERIADVAFELARTR-RNKVTSMEKRNVMK-SGVLW---------------- 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + ++ ++ ++ ++ADA Q++ P ++DVI NL GD +SD A Sbjct: 204 ---NQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFDVILTDNLFGDLLSDVAAMLT 260 Query: 318 GGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGW 369 G +G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ G Sbjct: 261 GSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASLAMCLRYSFGL 320 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + + G ++ T D +G + +E GDAI+ Sbjct: 321 VAEADRLEAAIAGVLDDGIRTADI--WSEGNTKVGTTEMGDAILAK 364 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 96/410 (23%), Positives = 158/410 (38%), Gaps = 60/410 (14%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I + GDGIG++VT A L V + I W + Sbjct: 1 MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFW---------KKE 51 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLY 125 +P+ T LI + G +T+ S + LRQ LDL+ Sbjct: 52 GAAIPSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLF 111 Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 +RP P + I RENSE +Y G ++ K I L E Sbjct: 112 ANVRPCFSIDDQSKPF------NFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQH 161 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + + ++ S+ G RL A ++A+ VTL K N+++ + + Sbjct: 162 WQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIF 221 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 A+ +I + DA ++ P ++ VI N+ Sbjct: 222 ESTAQRY--------------------PKIQADILNVDAVALWLIKSPEKFGVIVAENMF 261 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GD +SD A +GG+G+AP ANIGD+ + FE HG+ P+ ++ NP ++ L+ M+L Sbjct: 262 GDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRI-RKNCANPSAMFLTISMLLN 320 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 H G+ + A IV + I K D ++ +A+IE+ Sbjct: 321 HFGYPDRAKKIVNAVMQVIKEKR-----FITYDLGGHATTTDMANAVIEH 365 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 316 bits (810), Expect = 1e-84, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 171/402 (42%), Gaps = 60/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 N +EGDGIG ++ A + V+ AA++ + K++ + G S + + Sbjct: 3 NLKFLVLEGDGIGPEIAKASVDVLQAALK---LYDLKVNLVYEEIGFASLKKH--KTTFR 57 Query: 86 AETLDLIREYRVAIKGPL----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +E L + + I G P G + + +R+ DLY +RP + G Sbjct: 58 SEVLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF 117 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 P D ++ REN+E Y+ GV ++ I I+ Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNM----------------FKGVGELMPTPDVAISIRNI 159 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + +G+ R+ +YA+ R + +HK N++++++G F + Q++++ Sbjct: 160 TRKGSTRIAEIGFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKY--------- 209 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 E+ K+ I D+ ++ P+ +DVI NL GD +SDA + GG+G Sbjct: 210 -----------PEVEYKEQIVDSMSAMLIRDPSVFDVILATNLFGDNLSDAASEIAGGLG 258 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------WTEAAD 374 +A N G+ + +A HG+AP AG++ NP S+I S MML +G E A Sbjct: 259 LAESINAGENYCIAQAQHGSAPDIAGKNIANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQ 318 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I ++ I R D L ++F D +I N+ Sbjct: 319 MIEDAIDKTIIN-----PKTRTSDIGGNLSTTDFTDVLISNL 355 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 315 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 97/395 (24%), Positives = 154/395 (38%), Gaps = 48/395 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + DGIG ++ A ++V+ +A + +++ G S + YG L E Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSAD---SVFKLDLAFDYDDVGFTSLEKYG--TTLRDE 56 Query: 88 TLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L + Y I G G R+++ R LDLY +RP R S ++ Sbjct: 57 VLAKAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMRE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI RE +E Y G ++ I ++ + Sbjct: 117 GRTMDLVIMREATEGFYPDRNMT----------------KGWAELMPSPDMAISLRKITR 160 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 ++R+ R A E A+ + VT +HK N T+G F + +AR+ Sbjct: 161 HCSERIARRAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDF----------- 208 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 E+ + D++ DA ++ P +DV+ N GD ISD + G +G+A Sbjct: 209 ---------PEVRLDDLLIDASTAHLVRAPERFDVLVATNFYGDIISDLASELSGSLGLA 259 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA--ADLIVKGME 381 D +A HG+AP AGQDK NP S+ILS M+++ MG A L Sbjct: 260 GSMMASDTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQWMGEHHQNPAYLAAAQAM 319 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + R D C FG + + + Sbjct: 320 EAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKVI 354 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 153/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG DVT A V++ + A G + G + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENG--SMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA+ ++ ++ + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PADGIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 ++ + D++ REN+E Y+G + I Sbjct: 117 LRS-DGFDILCIRENTEGEYSGAGGRIHQGA-------------------DNEVAIETAI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +G +R++R E A A R + V K N K++ + + + L+ E Sbjct: 157 FTRKGVERILRFGFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+A NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVAASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G T AA+ ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLEHLGETAAAEKVM 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E + +++ + Sbjct: 316 DAIETTTARGV--------GAIPGKDRTDAITASVLSAL 346 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 89/409 (21%), Positives = 162/409 (39%), Gaps = 64/409 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + GDGIG +V + +++D + G + V + Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIA---SFETEHGLVGGAAYDA--DKVAIT 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTP- 138 T+ L + I G + P + + LR++L L+ LRP Y Sbjct: 58 DATMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAE 117 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 S +K E D++I RE + +Y G + + Sbjct: 118 ASSLKPEVVEGLDIMIVRELTGGVYFGEPKTITD------------------LGNGQKRA 159 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 I + +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 160 IDTQVYDTYEIERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYK- 216 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ ++ +AD+ ++ P ++DVI NL GD +SD A Sbjct: 217 ------------------DVQLEHQLADSGGMNLVKWPKQFDVIVTDNLFGDMLSDIAAM 258 Query: 316 QVGGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++ G A++E HG+AP AG+ NP +++ S M LR+ + Sbjct: 259 LTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGLANPVAMLASFGMALRYSL 318 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + T D + +G+ ++ S+ G+AI++ M Sbjct: 319 DMGELADKLDEAIAVVLARGLRTADIK--SEGSTVVSTSQMGEAIVQEM 365 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 96/401 (23%), Positives = 163/401 (40%), Gaps = 55/401 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P++ + + GDGIG +V +++++ + G Q G+ Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHL--DGVEFQLDRHSVGVGEYQRSGE-- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 LP D + G + P G + + LR+ L LY +RP+R Y Sbjct: 57 ALPQSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEAD 116 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 +P+K P D V+ RE++E ++ G + Sbjct: 117 TPLKGHGPGEIDFVLVRESTEGLFYGRD---------------------AIADLEADEAT 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + ++R+ R A E A + +VTL+ K N++ + F+ ++A+E Sbjct: 156 NLLRITRSASERVCRLAFETARRRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFL-- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I + V DA ++ RP ++DV+ N+ GD +SD A Sbjct: 213 ------------------DIKAEHVYVDAAALFLVRRPQDFDVMVTENMFGDILSDLAAG 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+AP +IGD+ A+F+ +HG+AP AGQ NP ++ LS MML + E Sbjct: 255 LVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMMLEWLDHPET--R 312 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A A ++ +R D L E D I E + Sbjct: 313 RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAERL 353 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 312 bits (799), Expect = 1e-83, Method: Composition-based stats. Identities = 87/362 (24%), Positives = 151/362 (41%), Gaps = 54/362 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I GDGIGVDVT A ++V+ AA + G + +G+ + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAAK----GRFAFDTTSFPWSCEYYLEHGR--MM 55 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + G + P + L + +R+ + Y +RP R G P Sbjct: 56 PEDGIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGP 115 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + + Sbjct: 116 LK-AEGFDILCIRENTEGEYSGAGGRVHEGK-------------------GNEVAVETSV 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R E A + R +T V K N K++ + + +LA E Sbjct: 156 FTRAGVERILRFGFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEY-------- 206 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + + DA ++++ P + DV+ NL GD ++D AA GG+ Sbjct: 207 ------------PDVTVSHMHIDAMAAKMVMAPQDLDVVVASNLFGDILTDLGAAIQGGL 254 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP AG++ NP + I S ML H+G E + ++ Sbjct: 255 GFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAIWSVAQMLDHLGEAEVSAAVL 314 Query: 378 KG 379 Sbjct: 315 SA 316 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 77/401 (19%), Positives = 159/401 (39%), Gaps = 64/401 (15%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I + GDGIG +++ ++V+ A EK K+++ G + G P Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEK---FGHKVNYEYAICGADAIDKVGDP--FPE 57 Query: 87 ETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT-- 137 ET + + + + P +A+R++L L+ +RPV+ ++ Sbjct: 58 ETYRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVH 117 Query: 138 PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP++ E D + RE + +Y G +++ Sbjct: 118 KSPLRAELVEGADFLCIRELTGGMYFGEKYQ------------------------DNDKA 153 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 154 YDTNMYTRPEIERILKVGFEYAMKR-RKHLTVVDKANVL-ASSRLWRQIAQEMAPQY--- 208 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 E+ + D +++ P +DV+ N GD ++D + Sbjct: 209 -----------------PEVTTDYMFVDNAAMKMIQEPKFFDVMVTENTFGDILTDEGSV 251 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 G +G+ P A+ G+ +FE HG+ P+ G + NP + ILS M+ + L Sbjct: 252 ISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYFDCKAEGAL 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I K ++ +++A T + + ++G + E G I++ + Sbjct: 312 IRKAVDASLDANVRTPEIQ--VEGGEKFGTKEVGAWIVDYI 350 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 309 bits (792), Expect = 1e-82, Method: Composition-based stats. Identities = 104/399 (26%), Positives = 166/399 (41%), Gaps = 60/399 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GD IG ++ P ++V+ AA + I W +I G + G LP Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAAR---TGLAIEWQDIPIGRAALDSLG--STLPDG 56 Query: 88 TLDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 T++ + + GP+ P + + LR+ DL+ +RPV+ + P Sbjct: 57 TIERLDALDGWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---H 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E A S + R I ++ + Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGE----------------FRPTPDVTISVRVITRN 157 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G+ ++ RAA E A A R +T VHK + K G F + +LA E Sbjct: 158 GSSKVARAAFELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEY------------ 204 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + I D F ++++ P YDV+ N+ GD ++D A VGG+G+A Sbjct: 205 --------PDVTYDEAIVDTFAMRLVMTPQRYDVVVTTNMFGDILTDEAAGLVGGLGMAA 256 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLIV 377 G G A+ +ATHG+AP AG+ NP ++I+S +M+L +G AA LI Sbjct: 257 GLCAGPRHAMAQATHGSAPDIAGRGIANPYAMIMSGQMLLDWLGRRHAEPAATAAARLIE 316 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + I + D + G AIIE M Sbjct: 317 QAVANMIEERR-----ALTPDLGGQGTTAGMGSAIIEAM 350 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 91/400 (22%), Positives = 155/400 (38%), Gaps = 66/400 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG ++ L+++ EK + + G S YG L Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYH---LESHHFGGVSIDYYGTP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTP--S 139 ETL + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 NETLQSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLS 116 Query: 140 PVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G + + Sbjct: 117 PLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTE-----------------------ALD 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S + +R+VR A A R +T V K N++ + ++ + ++ Sbjct: 154 SLKYSSQEIERIVRIAFNLANRR-RKKLTSVDKENVL-SSSKLWRQIVNDVKKDY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ +P ++DVI NL GD +SD + Sbjct: 207 ---------------PEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ G L+E HG+AP A +DK NP ++LS + LR + +AA+ Sbjct: 252 GSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + I + T D + SE + E Sbjct: 312 LESIVYSFIQSNKTTADL------GGQYRTSEIFKLLKEK 345 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 308 bits (790), Expect = 2e-82, Method: Composition-based stats. Identities = 101/394 (25%), Positives = 166/394 (42%), Gaps = 71/394 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDG+G ++ A L +++ ++EI G+ G+ + Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLER--------YIGADFIEIKAGKSYFIEEGKP--IEDN 51 Query: 88 TLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ++ IRE +KGP+ TP G S+N LR+E LY +RP R Y+G Sbjct: 52 AIEKIRECDSLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISIR-----R 106 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D ++ REN E +Y G E + E I ++ ++ G Sbjct: 107 IDTILVRENLECLYYGWEVE------------------------DEDRAIAMRVITKRGA 142 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ A A R VT +HK NI+K T+G F D Y++A + Sbjct: 143 ERISEFAFNLAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-------------- 188 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ D I DA +++ +DV+ NL GD +SD A VG IG+ A Sbjct: 189 -------DLRADDEIVDAAGYKLVKLDNAFDVMLTPNLYGDILSDVAAGVVGSIGLCGSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW----TEAADLIVKGMEG 382 IG++ A FE HGT AG+ NP +I++A MML + + + I + ++ Sbjct: 242 QIGEDFAAFEPIHGTGEDIAGKGVANPIGMIIAASMMLDWLWERGRSPKRGEKIREAVDS 301 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +T D + + + I++ + Sbjct: 302 VIRDRILTPDL------GGDFRTEQVVEKIVDRL 329 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 308 bits (790), Expect = 2e-82, Method: Composition-based stats. Identities = 100/390 (25%), Positives = 167/390 (42%), Gaps = 66/390 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P I I GDG+G ++ A++ V++ + + G+++ + G V LP Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSD---LMNLPLDLRFFEAGDETKRKRG--VALPE 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ETL+ + + + R + + LRQ+LDLY+ LRP + Y + Sbjct: 57 ETLNGVMNSDATLMVAIG----ESAREVILPLRQKLDLYVNLRPAKSYP----VPRAIPG 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+ I REN+ED+Y W+ + ++ + + Sbjct: 109 FDLTIVRENTEDLYVMSGWR------------------------GLDTAVDLRIITRRAS 144 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R YA + V +VHK N++ F++ ++A EE Sbjct: 145 ERICRFGYRYARERGKSRVYVVHKANVL-GGCMLFREVCSRVAEEEGFD----------- 192 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +++ D+ +I + +DVI N+ GD +SD AA +GG+G+ P A Sbjct: 193 ----------YREMYVDSAAMRIAMDRP-FDVIITTNMFGDILSDLAAAFIGGLGMYPSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+ A+FE HGTAP+ AG++ NP + ILSA MM+ +G + LI + + A Sbjct: 242 NIGESRAIFEPVHGTAPEIAGKNIANPMATILSAAMMMGWLGHEGGSKLIEEAVRRACEL 301 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D ++ E G I E M Sbjct: 302 GYTTPDV------GGSMRTKEVGLKISEIM 325 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 87/403 (21%), Positives = 154/403 (38%), Gaps = 64/403 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG + + K++ E G E G + +G + + Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAG---FVTDEGLVGGCAYDAHG--AAISEADMQ 62 Query: 91 LIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + G + P + + LR++L L+ LRP Y S Sbjct: 63 KALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLK 122 Query: 145 ----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D++I RE + +Y G + + + GI + Sbjct: 123 PELVEGLDILIIRELTGGVYFGEPKEIID------------------LGNGQKRGIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ A E A ++ V + K N+MK + + + + ++ Sbjct: 165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMK-SGVLWNQVVTETHKAKYS------ 216 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ ++ ++ADA Q++ +P ++DVI NL GD +SD A G + Sbjct: 217 -------------DVQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ + Sbjct: 264 GMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNMVKE 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + K + ++ T D DG + + E G+AI+ Sbjct: 324 ADDLEKAIANVLDKGIRTGDIM--ADGCRQVGTVEMGEAILAE 364 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 88/419 (21%), Positives = 153/419 (36%), Gaps = 73/419 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD IG ++ +KV+ + + G S +G V Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETH--RPNLHFNLTTDLVGGTSIDTHG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPV-RYYQGT 137 + LD + + G + P G S + LRQ LD + LRP Sbjct: 57 PITQSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSL 116 Query: 138 --PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP++ + T ++ REN Y G + + E Sbjct: 117 VGASPIREHVVKGTRFIVVRENCGGAYFGEKKEE------------------------ED 152 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGY 246 + + +RL R + A R +V K N++ + ++ Sbjct: 153 VASDLWVYTRPEIERLARVSAAVARIMGRSEDDNQAATVWSADKANVL-ASGRLWRRITS 211 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLN 305 + +EF +I ++ +AD+ ++ P ++ VI N Sbjct: 212 DIFAKEF-------------------PDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTF 252 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECA-------LFEATHGTAPKYAGQDKVNPGSIIL 358 GD +SD A G +G+ P A++ ++E HG+AP +G+ NP + IL Sbjct: 253 GDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQIL 312 Query: 359 SAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 S MMLR+ MG + A + + + ++AK+ R D CS+ GDA+ E + Sbjct: 313 SVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCEVL 371 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 110/398 (27%), Positives = 173/398 (43%), Gaps = 72/398 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I ++G+GIG ++T A ++V++A + W I +++ ++YG LP + Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQ 52 Query: 88 TLDLIREYRVAIKGPL-------------TTPVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I++ + IK PL T S+N A+R+EL+L++ RP+R Y Sbjct: 53 VIQRIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGY 112 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G E DMVI RE +ED Y G E + A Sbjct: 113 VGISG---RHEKMDMVIMREITEDTYIGWEKPLEDGAA---------------------- 147 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK + + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 148 AEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLY-- 205 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 +IV D++ DA ++ P +DV+ +N GD SD A Sbjct: 206 ------------------PDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDIFSDLAA 247 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+APGANIGD + FEA HG AP AG NP ++ILS +L H G+ + ++ Sbjct: 248 GLAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHAGYGKGSE 307 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 I + + I A D + DAI Sbjct: 308 AIREAVTRVIEAGR-----TLTPDLGGRSTTEQVADAI 340 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 307 bits (786), Expect = 5e-82, Method: Composition-based stats. Identities = 88/391 (22%), Positives = 158/391 (40%), Gaps = 73/391 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK-ISWMEIYTGEKSTQVYGQDVWLPA 86 + I G GIG ++T ++ V +A ++ Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEALHVPIKFDVLDNFNFEN------------------D 75 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ++ +R+ + G + T N + LDLY + +G + Sbjct: 76 DSKSQLRKNECILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNN 130 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 TD+V+ REN+E Y+G+E + E IK +++ + Sbjct: 131 TDIVVIRENTEGEYSGVEHEVYPGVVE-----------------------SIKVTTKQAS 167 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 R+ A E+A + R VT VHK NIMK +G F ++A+ Sbjct: 168 LRIAEYAFEFAHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSF------------ 215 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 I +++I D Q++ P ++DV+ NL G + + +A GG+G+A GA Sbjct: 216 --------IKYEEMIIDNCCMQLVKNPTQFDVMVMPNLYGSIVQNVVAGITGGVGMAAGA 267 Query: 327 NIGDECALF-EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 +IG + ALF + T AG++ VNP ++++S+ ++LRH+G AD I + ++ I Sbjct: 268 SIGKDHALFSQGCRHTGRDIAGKNVVNPSAMLVSSTLLLRHLGLPNFADQICRAVQHTIQ 327 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D +F +I ++ Sbjct: 328 DKKI-----KTKDIGGNATTDQFTSEVIRSL 353 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 104/400 (26%), Positives = 164/400 (41%), Gaps = 61/400 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG +V LKV+ A + + E G + G+ L Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRH---GLTLDTTEYELGAQRWHATGE--VL 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P + +R++ + G + P R L + LR Y+ LRPVR Y G +P+ Sbjct: 59 PDAVEEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPL 118 Query: 142 K--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 PE DM++ RE +E YAG+ GV + P Sbjct: 119 AGVAPEDIDMLVVREGTEGPYAGMG-------------------GVLRKGTPHEIATQDS 159 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R+VR A A +TLVHK N++ + ++ ++ E Sbjct: 160 VNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEY------- 212 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + + DA + +P +DV+ NL GD I+D AA GG Sbjct: 213 -------------PQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGG 259 Query: 320 IGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 IG+A NI E ++FE HG+AP AGQ K +P + ILS +ML H+G+ +AA I Sbjct: 260 IGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGYADAAAQI 319 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D + + ++ GD I + + Sbjct: 320 DQAVAE---------DLQERAKNGGVRSTTQIGDDIAQRV 350 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 304 bits (778), Expect = 5e-81, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 163/404 (40%), Gaps = 63/404 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + + GDGIG +V L+V+ AV + + + G GQ Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPA----DVSLDTTQYPFGAGHFLETGQ-- 54 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 L L + ++ + G + R L + LR D YI LRP Sbjct: 55 ILTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLP 114 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G SP+ P D V+ RE +E YAG GV + Sbjct: 115 GVASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIA 155 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + G +R VR A E A DR VTLVHK N++ F ++ ++A E Sbjct: 156 TEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAE---- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + DA + ++ P+ +DVI NL GD I+D AA Sbjct: 212 ----------------HPDVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAA 255 Query: 316 QVGGIGIAPGANIGDECA---LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 GGIG+A N+ A +FE HG+AP AGQ K +P + ILS ++L H+G +EA Sbjct: 256 ISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEA 315 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + + A T D +E GDAI+ + Sbjct: 316 AARVSAAVSDDLAA-RATGDAAPR-------STAEVGDAILRAL 351 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 93/397 (23%), Positives = 167/397 (42%), Gaps = 64/397 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 V + + + GDG+G ++ A+ +V AA E +S ++ E+ Sbjct: 45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL------- 97 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G Sbjct: 98 ---EQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGY--- 151 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+VI RE +E Y+ +E ++ E +K Sbjct: 152 MTRHNNLDLVIIREQTEGEYSSLEHESARGVIE-----------------------CLKI 188 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + ++R+ + A +YA R VT VHK NIMK +G F ++A Sbjct: 189 VTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY-------- 240 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I + +I D Q++ P ++DV+ NL G+ I + A VGG Sbjct: 241 ------------PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGA 288 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ PG + E A+FE + G++ NP +++LSA MLRH+ + +I Sbjct: 289 GVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ + R D ++F ++I ++ Sbjct: 349 VKK-----VIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 97/399 (24%), Positives = 162/399 (40%), Gaps = 65/399 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + G GIG + + + I + + Sbjct: 50 KAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYI-------GAPIDFEVVDI-----DPTM 97 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTP 138 + + I+ V +KG + T S NVALR ELD+Y + + Y G Sbjct: 98 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 157 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + D+VI R+N+E YA +E ++ + E + Sbjct: 158 T---RHKDIDVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SM 191 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K + + ++R+ R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 192 KVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY------ 245 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 +I D+I D Q++ +P ++DV+ NL G +S+ + +G Sbjct: 246 --------------PDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLG 291 Query: 319 GIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G G+ G N GD A+FE T T AG++ NP ++I ++ ML H+G A L+ Sbjct: 292 GAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEHLGHQFHASLLR 351 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + IN D D ++ AI++N+ Sbjct: 352 RAINKTIN-----VDRVLTPDLGGSNTSTDVVGAILQNV 385 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 101/413 (24%), Positives = 159/413 (38%), Gaps = 74/413 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V+ A ++V+ A+ I + + G + + G Sbjct: 11 DGYRIAVVPGDGIGPEVSAATVRVLTQAL----GTSFPIEFRDYDAGAECFRRTG--TAF 64 Query: 85 PAETLDLIREYRVAIKGPLTTPV------GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 P T R+ + G P + ++ +R LDLY +RP+R +G P Sbjct: 65 PEATQVACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAP 124 Query: 139 SPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + K P+ I REN+E +YA Sbjct: 125 RRLVGKGPDDIRFTIVRENTEGLYAARG---------------------GGNIIRGQIAT 163 Query: 197 GIKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + EG +R+VR A E A A+ VT+V K N+++ + F++ + Sbjct: 164 DTLVMTREGVERIVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIADGVLA 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + I ++ VI DA ++ RP +DVI C NL GD +S Sbjct: 223 D--------------------CPGIEVEHVIVDAMTVHMIERPEHFDVIVCENLFGDILS 262 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-- 368 D AA +GG+G+AP IG + F+ +HG+AP AG+ NP + ILS MML +G Sbjct: 263 DLGAAIMGGMGLAPSGEIGRDHGYFQGSHGSAPTIAGKGLANPIACILSGAMMLDWLGKR 322 Query: 369 -----WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA+ I + + A D I + Sbjct: 323 HSDPALTRAAERIREATGAVLKAGR-----AVTPDIGGSGSTESCAAEICATL 370 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 95/412 (23%), Positives = 163/412 (39%), Gaps = 65/412 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I ++ GDGIG +V + +V+D G + G + G + Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLN---QTGRTAFEVEDALVGGAAYDAQGTPL 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 +T+ L + G + P + LR++L+L+ LRP + Sbjct: 58 H--DDTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFD 115 Query: 136 GT----PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + D++I RE + +Y G G+ + Sbjct: 116 ALAEASTLKTELVSGLDVMIVRELTGGVYFGQPR------------------GISALPNG 157 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E G+ + R+ + A + A + V K N+M+ + +++ +L + Sbjct: 158 ERRGVNTQVYDTHEIVRVAKVAFDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGAD 215 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 EI + + AD Q++ +P ++DVI NL GD +SD Sbjct: 216 Y--------------------PEIALSHMYADNCAMQLVRQPKQFDVIVTDNLFGDILSD 255 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 A G +G+ P A++ G+ A++E HG+AP AGQDK NP + ILS MMLR Sbjct: 256 CAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDKANPLATILSFSMMLR 315 Query: 366 H-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E ADL+ + G + T D + G L+ + GDA++ M Sbjct: 316 YSFDLAEEADLVDNAVRGVLAKGLRTGDIFQP--GKTLVGTTGMGDALLAEM 365 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 85/412 (20%), Positives = 155/412 (37%), Gaps = 71/412 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD +G ++T +KV+ A + + K + G + G V Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVR-----Y 133 LP E L+ ++ + G + P G + +R+EL LY LRP Sbjct: 57 PLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSL 116 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +P + + TD V+ RE IY G + D + Sbjct: 117 LDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDG----------------------DG 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ R A A+ ++ + + K N++ + ++ + + E Sbjct: 155 VAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVL-ASSRLWRKTVEETIKNE 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISD 311 F + ++ + D+ ++ P + +I N+ GD ISD Sbjct: 214 F-------------------PTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISD 254 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + G +G+ P A++ L+E HG+AP ++KVNP + ILSA MML+ Sbjct: 255 EASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-PKNKVNPIATILSAAMMLK 313 Query: 366 -HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E I ++ ++A T D +E GDA+ E + Sbjct: 314 LSLNLPEEGKAIEDAVKKVLDAGIRTGDL------GGSNSTTEVGDAVAEEV 359 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 300 bits (767), Expect = 8e-80, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 168/401 (41%), Gaps = 63/401 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ A ++V+DA E + R ++EI G + + G V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTG--VACAEA 61 Query: 88 TLDLIR-EYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + +R E +KGP+ TP G L LR LD Y +RPVR + G PS V Sbjct: 62 DVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRV 121 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + D VI REN+E +YA Sbjct: 122 -RADRVDYVIVRENTEGLYASRGKGVG----------------------NRWAVTDTLLT 158 Query: 202 SEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + EGT R+ R A A VT V K N+++ + F++ ++A E Sbjct: 159 TREGTLRVARKAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEF--- 214 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 E+ ++ ADA Q ++L P +DV+ N GD +SD A Sbjct: 215 -----------------PEVELEYRYADAAAQDLVLCPERFDVLVMENFLGDVLSDLGGA 257 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+ P N+GD A FE HG+AP G+++ NP +L+A M+L H+G + A Sbjct: 258 TVGGVGLCPAGNVGDGAAYFEPVHGSAPDLVGRNRANPVGQLLAAAMLLDHLGHVDEAAR 317 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + + TV + + + G DA+I + Sbjct: 318 LRRAVSAVLAFGTVRIEADGTVLGGA----EAVADAVIAAL 354 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 300 bits (767), Expect = 9e-80, Method: Composition-based stats. Identities = 87/406 (21%), Positives = 161/406 (39%), Gaps = 63/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIGV+V + +++D K + + E G + V+G PAE Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPY--PAE 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGT---- 137 TL+ + G + P + +R+++ L+ LRP + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + D++I RE + +Y G G+ + G Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPR------------------GIDTLPDGTRKGYN 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ R A + A + + V K N+++ T +++ +L +EEF Sbjct: 162 TLVYTTPEIQRIGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEF---- 215 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ + + D Q++ P ++DV+ N+ GD +SD A Sbjct: 216 ---------------PDVELTHMYVDNAAMQLVRNPKQFDVMVTENMFGDILSDCAAMLT 260 Query: 318 GGIGIAPGANIGD------ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 G +G+ P A++G+ AL+E HG+AP AG+D NP + I+S M LR+ Sbjct: 261 GSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANPLATIMSFAMCLRYSFDMA 320 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI ++ + T D + G + + G+A++ + Sbjct: 321 AEADLIETAVKNVLKGGLRTADIMQP--GKAKVSTTVMGEAVVREL 364 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 300 bits (767), Expect = 9e-80, Method: Composition-based stats. Identities = 106/391 (27%), Positives = 158/391 (40%), Gaps = 74/391 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +V ++V+ A + + + G Q G + Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR-------VRFEYYEGGVDVFQECGSP--IRE 52 Query: 87 ETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E L+ IR + G TTP G RSL + LR+EL LY LR + Sbjct: 53 EDLEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLR---IIPDLRT------ 103 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 ++VI RENSE +Y GI + + ++ + EG Sbjct: 104 GREIVIVRENSEGLYFGIGAVVNG------------------------RAVDVRLITREG 139 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 +R+ R A+E A A +T VHK N++ + F+ ++A EE Sbjct: 140 AERIARFAVEQAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE------------- 184 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + ++D I D+F +++ P E+ VI NL GD +SD G IGI P Sbjct: 185 --------GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVPS 236 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 N GD ALFE HG+AP AG+ NP ILS M+L ++G LI + G + Sbjct: 237 GNYGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLGLD--GSLIRAAVRGYVV 294 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D + + II + Sbjct: 295 NGELTPDM------GGRARTEDVVRGIIGEI 319 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 299 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 97/407 (23%), Positives = 158/407 (38%), Gaps = 78/407 (19%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 ++ + + GDGIG +V +++A E + + EI G + +G Sbjct: 6 AKDSYQVVLLPGDGIGPEVMAQARDLLEAVAEPS---GVRFELDEIPCGGRFYLEHGARD 62 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRP 130 W P + R V + G + P G S + R +LDLY +RP Sbjct: 63 W-PEDAEARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRP 121 Query: 131 VRYYQGTPSPVK-------HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 V+ G + PE DMVI REN+E +YAG+ + + Sbjct: 122 VKLLPGVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSAS--------- 172 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKF 236 + + G +R++R A E R VT + K N+++ Sbjct: 173 ----------VATDTRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE- 221 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 F + ++A E +I + I DAF Q ++ +P Y Sbjct: 222 GCKLFAEVFAEVASEY--------------------PDIANELAIVDAFTQWLVTQPEHY 261 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSI 356 DV NL GD ++D + GG+G+A G N+GDE A+FE HG+AP AG+D+ NP ++ Sbjct: 262 DVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEHAMFEPIHGSAPPLAGKDEANPMAM 321 Query: 357 ILSAEMMLRHMGWTE-------AADLIVKGMEGAINAK-TVTYDFER 395 +L+ L +G A + + + +T D Sbjct: 322 LLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVDLVG 368 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 298 bits (764), Expect = 2e-79, Method: Composition-based stats. Identities = 109/393 (27%), Positives = 176/393 (44%), Gaps = 65/393 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG--QDVW 83 + ++GDGIG +V +ML+V+ + + G + G + Sbjct: 2 SKKAAVMKGDGIGPEVVDSMLRVLKEC-------NFQSELILCEAGSEQWDKNGRKDASY 54 Query: 84 LPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 +P T+ ++ E KGP TT PV G RS+ V LRQ+ DLY +RP + Y + Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYD----RLT 110 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D V FRE +E +Y G+E + + I I+ + Sbjct: 111 PDRKLDCVCFREATEGLYTGVE-----------------------AKITDDAAIAIRKIT 147 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +G++RL+ +A+++A + + V K NI+K T+G F Sbjct: 148 RQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGIF--------------------- 186 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGI 320 W + + G +I + ++ D QQ+++ +++ V+ NL D IS+ +A VG I Sbjct: 187 WDETQKAVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELASALVGSI 246 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ ANIGD A+FEA HG+AP++AGQ+KVNP + +LS M ++G + D I Sbjct: 247 GLIYSANIGDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMADYLGERDVRDAIFAAT 306 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E IN D ++ DAII Sbjct: 307 EQVINEGK-----AVTWDIGGDASTTQMTDAII 334 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 297 bits (759), Expect = 7e-79, Method: Composition-based stats. Identities = 102/388 (26%), Positives = 154/388 (39%), Gaps = 60/388 (15%) Query: 39 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 97 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 98 AIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPELTDMVIF 152 + G L P R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 212 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 213 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTG 272 A +YA AN R VT+ K N M+ + +++ + Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEVRAQY-------------------- 214 Query: 273 KEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-- 330 EI V DA ++ P ++ VI NL GD ++D AA GG+G+A AN+ Sbjct: 215 PEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGAALQGGLGMAASANVHASD 274 Query: 331 --ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 ALFE HG+AP AG+D NP + +L+A ++L H+GW E I + + A++ Sbjct: 275 PARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLGWPEEERRIERWVSQALDQGM 334 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D L G + E + Sbjct: 335 CTVDV------GGTLGTRAAGAWVREQI 356 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 88/415 (21%), Positives = 148/415 (35%), Gaps = 73/415 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I + GDGIG ++ + L V++ E+ G + + G Q G Sbjct: 1 MKRDLRFHIAVLPGDGIGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG- 57 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQG 136 E + ++ + G + P G + + LR E+DLY LRP+R Y Sbjct: 58 -TAFSDENMAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPS 116 Query: 137 TPSPV--KHPELTDMVIFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 P + K D+V+ RE +E I Y+ + + Sbjct: 117 LPRVLVDKRASQIDLVLVREQTEGILYS----------------------RCRGTIEDDR 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDR-----DSVTLVHKGNIMKFTEGAFKDWGYQL 248 S GT R+ A A + V V + N + + F+ ++ Sbjct: 155 VAWETMMISRNGTSRVSEFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEV 213 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A + D +++ P E+DV+ N G Sbjct: 214 AER--------------------HPSVSADYAYVDTTAMKLVKSPWEFDVLVTENAFGGI 253 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM- 367 +SD A VG +G+AP A+IG++ A+F+ HG+AP AGQ NP + ILS +ML + Sbjct: 254 LSDLAAGVVGSLGLAPSADIGEKHAVFQPAHGSAPHIAGQGLANPVAQILSVALMLDWLA 313 Query: 368 ------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ +E A+ ++ + AII + Sbjct: 314 DQHGEPRLAHGARILEHAVEKALT-------VVCPVEFGGKDGTAAITKAIIAQI 361 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 295 bits (754), Expect = 3e-78, Method: Composition-based stats. Identities = 89/411 (21%), Positives = 149/411 (36%), Gaps = 71/411 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + G S + L Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAG-KFNLQNHLLGGASIDKHNDP--LT 59 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-----IRSLNVALRQELDLYICLRPVR-----YYQ 135 E L+ + + G + P G + LR+EL Y LRP Sbjct: 60 DEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVD 119 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 +P + TD ++ RE + IY G + D + Sbjct: 120 SSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSG----------------------YA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 +P S R+ R A A+ N V + K N++ T ++ + +EF Sbjct: 158 CDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ ++ + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIGDEC-------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 + G IG+ P A++G ++E HG+AP +G+ VNP ILS MMLR+ Sbjct: 258 SVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRY 317 Query: 367 -MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + AD + ++ AI+ T T D S+ G+A++ + Sbjct: 318 SLNLPKEADAVEAAVKAAIDNGTKTKDL------GGNATTSDMGNAVVAEL 362 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 99/394 (25%), Positives = 155/394 (39%), Gaps = 68/394 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + + GDGIG +V A + A A + + + E G + + G V Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGT- 137 ETL E + G + P G + +ALR+EL + LRPV Sbjct: 58 --SKETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALS 115 Query: 138 ---PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 P E D++I RE + Y G + E Sbjct: 116 GSSPLRPGVAEGVDLLIVRELTGGAYFG------------------------EKEEGEER 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + + +R+ R A E A R V V K N++ T ++ ++AR+ Sbjct: 152 ASDLSVYTRGEVERVARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDY-- 207 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ ++ V+ DA ++ P +DVI NL GD +SD A Sbjct: 208 ------------------PDVALEHVLVDAAAMHLVTDPGRFDVILTENLFGDILSDEAA 249 Query: 315 AQVGGIGIAPGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 G +G+ P A++G+ +FE HG+AP AG+ NP + ILSA MM RH +G E Sbjct: 250 VLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPYAAILSAAMMFRHGLGRPE 309 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 AA+ I +G+E A+ A +T D Sbjct: 310 AAEAIERGVEAAVAAGCLTPDL------GGSSGT 337 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 293 bits (750), Expect = 8e-78, Method: Composition-based stats. Identities = 86/418 (20%), Positives = 144/418 (34%), Gaps = 69/418 (16%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 I + GDGIG +V +V++ A + +I G S +G+ Sbjct: 3 KRTFKIVILPGDGIGPEVVAEATRVLEVVS--ASSSDVEIKLETHDFGGCSIDKHGEP-- 58 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVR-----Y 133 L A TL+ + + G + P G +ALR+ L LY +RP Sbjct: 59 LTAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSL 118 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +P D+++ RE Y G + R E Sbjct: 119 LAYSPLKPSVARGVDIIVIRELIGGAYFGERKELG-------------------ARAQED 159 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 160 AAWDTMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL-ASSRLWRKVATETIQNEF 218 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDA 312 ++ + + D+ I+ P + + VI NL GD +SD Sbjct: 219 -------------------PQLKLDHHLVDSASMLIVANPKKLNGVILTENLFGDILSDE 259 Query: 313 LAAQVGGIGIAPGANIGDEC-------------ALFEATHGTAPKYAGQDKVNPGSIILS 359 + G +G+ P A++ ++E HG+AP AGQ NP ILS Sbjct: 260 SSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIANPIGTILS 319 Query: 360 AEMMLRHMG-WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A M+ W A I +EGA + R D K + G ++E + Sbjct: 320 AAMLCGTRSVWRSPAKAIEAAVEGARRQGDR-REGLRTADLGGSSKTKDIGHKVVEIL 376 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 290 bits (742), Expect = 6e-77, Method: Composition-based stats. Identities = 110/396 (27%), Positives = 168/396 (42%), Gaps = 65/396 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 ++ I IEGDGIG +V PA + V+ A E S+ E G+ + G Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE------VGFSFTEKQAGDDTRDQTG- 53 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP T + + + G + + LR+ + ++ +RP R Y G + Sbjct: 54 -AALPETTYEAAADADATLFGAAG----ETAADVILPLREAVGSFVNIRPARAYPGVDAL 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 TD+V REN+E +Y+G E R E + Sbjct: 109 ---QPETDLVFLRENTEGVYSGHE-----------------------DRLSEDLSTLTRV 142 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +++L A Y D VHK N+M+ T+G F+D ++A Sbjct: 143 ITTSASEQLAEYACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVAA---------- 192 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ +V+ DAF ++ L P ++DV+ C NL GD +SD A VGG+ Sbjct: 193 -----------SNDVATNEVLMDAFATRVCLNPTQFDVVVCPNLAGDVLSDLAAGLVGGL 241 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ P ANIG ALFE HGTAP AG NP + ILSA M+L ++G T+AA + + Sbjct: 242 GLLPSANIGQTNALFEPVHGTAPDIAGDGIANPSASILSAGMLLEYLGETDAATNVQMAV 301 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E +N+ T D +A+IE + Sbjct: 302 ESVLNSGPRTPDL------GGNASTEAVVNAVIEQL 331 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 290 bits (742), Expect = 7e-77, Method: Composition-based stats. Identities = 102/393 (25%), Positives = 158/393 (40%), Gaps = 64/393 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +V LKV+ A + G Q G+ LP Sbjct: 2 RLAVIPGDGIGPEVVAEGLKVLRAVAP-------DVESTPYDLGASRWQRTGE--LLPDT 52 Query: 88 TLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD +R + + G + P G R L + LR ELD ++ LRP R + G SP+ P Sbjct: 53 VLDELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAP 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 DM+ RE +E Y G GV + P + + Sbjct: 113 GAIDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAF 153 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G +R+VR A E A+A R +TL+HK N++ + +++ E Sbjct: 154 GVERVVRYAFERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEF------------ 201 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 E+ + DA + P +DVI NL GD ++D AA GGIG+A Sbjct: 202 --------PEVTVAYQHVDAASMFFVTDPGRFDVIVTDNLFGDIVTDLAAAVTGGIGLAA 253 Query: 325 GANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 N+ G ++FE HG+AP AG+ +P + +LS ++L H+G + A + + Sbjct: 254 SGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSVGLLLDHLGRADQARKVNAAVA 313 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +D D ++ + GD + Sbjct: 314 ---------FDLS-TRDPEAQVRTEDVGDRLAA 336 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 289 bits (740), Expect = 1e-76, Method: Composition-based stats. Identities = 100/400 (25%), Positives = 171/400 (42%), Gaps = 62/400 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++ ++V++AA ++ + + G S Q +G + Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKR---FQLDLEIGHDIAGHASLQRHG--ATVTPA 56 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ ++ + GP+ T G + + R+ELDLY +RP R + G V Sbjct: 57 LLEKVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV-- 114 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 ++ + REN+E YA ++ S++ I ++ + Sbjct: 115 -GEFNLAVVRENTEGFYADRNIESGSSEML----------------ITPDTVISLRRITR 157 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+ R+A + A R V++VHK N++K +G F D Q+ARE Sbjct: 158 LCCERIARSAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVAREF----------- 205 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ + D I DA + ++ P +DVI N+ GD +SD A G +G+ Sbjct: 206 ---------PQVRVDDFIVDAMMAHVVRAPQRFDVIVTTNMFGDILSDLTAELSGSLGLG 256 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLI 376 N G + A+ +A HG+AP AG++ NP S+ILSA +L G + AA I Sbjct: 257 GSLNAGKDHAMGQAVHGSAPDIAGRNIANPYSLILSAGQLLGWHGQRKNLPAFALAARAI 316 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ A+ T D L +E G + + + Sbjct: 317 DETATAALQAREGTRD------AGGELGTAEAGQSFVRRL 350 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 284 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 97/454 (21%), Positives = 163/454 (35%), Gaps = 90/454 (19%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + +Q K L + + GDGIGV++ + ++ A +S Sbjct: 16 IQAASQPSKAFFSQSALQREAIKKVTLLPGDGIGVEICSCVCELFHYANIPIQWDTYLVS 75 Query: 65 WMEIYTGEKS-----------------------------TQVYGQDVWLPA----ETLDL 91 G S + P + Sbjct: 76 GSFFGVGSDSSLNPTRNLIEEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQS 135 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMV 150 I +V +KGP T +S++ L + LY + PV+ Q P V P DMV Sbjct: 136 ILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMV 193 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 + REN+E Y+G+E + E +K + +G+ R+ Sbjct: 194 VVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRDGSMRIA 230 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 231 KWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEY------------------ 272 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I ++I D + Q++ P +D V+ NL G +S+ ++ VGG+G+ G N Sbjct: 273 --PDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNA 330 Query: 329 G-----DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 D +FE A +G+ NP +I S+ ML HMG A+ I ++ Sbjct: 331 TDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMGMNTHANRIKFALKE 390 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D F +A++ ++ Sbjct: 391 TLLNA---NPKILTPDIGGTGSSVSFIEAMMRHI 421 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 283 bits (724), Expect = 8e-75, Method: Composition-based stats. Identities = 83/336 (24%), Positives = 141/336 (41%), Gaps = 55/336 (16%) Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQE 121 + E++ + + + IR RVA+KG + T +S N LR Sbjct: 1 DFEEVHVSSNADEED------IRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTS 54 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDLY + + G V + D++I REN+E Y+ +E ++ + E Sbjct: 55 LDLYANVIHWKSLPGV---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-------- 103 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +K ++ + R+ A + A + R VT VHK NIMK +G F Sbjct: 104 ---------------SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLF 148 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 ++A +I +++I D Q++ RP ++DV+ Sbjct: 149 LQCCREVAARY--------------------PQITFENMIVDNTTMQLVSRPQQFDVMVM 188 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSA 360 NL G+ +++ A VGG G+ GAN G A+FE AT T A ++ NP + +L++ Sbjct: 189 PNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLAS 248 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERL 396 MML H+ A I K + +++ + V + Sbjct: 249 CMMLDHLKLHSYATSIRKAVLASMDNENVRFPSHPT 284 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 283 bits (723), Expect = 9e-75, Method: Composition-based stats. Identities = 89/415 (21%), Positives = 153/415 (36%), Gaps = 68/415 (16%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + K K + + + I G+G+G ++ A+ +V+ A Sbjct: 62 QDKQKSKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKA------- 114 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W + E L +R +V IKGP+ + R +R++ Sbjct: 115 PIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQ 163 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 + + + +G SP D+VI R+ E Y+GIE + Sbjct: 164 FAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVVPGVMQT------- 213 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 IK + G R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 214 ----------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 257 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 + A + +++ ++ D + +ILL+P + DV+ Sbjct: 258 LEAMRAEADKHVD-------------------DVLFEERYLDTCILKILLKPHKCDVMVS 298 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 ++ GD + +G GI PG ++ +F+ AG+D NP +LSA Sbjct: 299 SSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAA 358 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MLRH+ + AD + + D R D KCSEF A+ + + Sbjct: 359 LMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 282 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 118/419 (28%), Positives = 189/419 (45%), Gaps = 70/419 (16%) Query: 7 VPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWM 66 + AQG + + II GDGIG +T ++++ ++ K+ + Sbjct: 27 MKAQGDFLNY-----QALDKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQG-KVEFK 80 Query: 67 EIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQEL 122 I G + + +PAE L ++E V +KGP TTP + S NVA+R+EL Sbjct: 81 VID-GLTIERRAAEHAAIPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKEL 139 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DL+ +RPVR + + D +REN+E YA Sbjct: 140 DLFANVRPVRIPE---------QGIDWTFYRENTEGAYA--------------------- 169 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 +G K I E G+ + G++R++RAA EYA AN + VT V K NI+K T+G F Sbjct: 170 VGSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDGKFL 229 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQIL--LRPAEYDVIA 300 D ++A++ K+I D D +++ R ++ V+ Sbjct: 230 DIFREIAKDY--------------------KDITADDWYIDIMTAKLIDEKRRKDFQVMV 269 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSII 357 NL GD I+D A GG+G A ANIG ++FEA HG+AP+ + + +P S+I Sbjct: 270 LPNLYGDIITDEAAEFQGGVGTAGSANIGKRYSMFEAIHGSAPRMVQEGRDQYADPCSVI 329 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + M+L H+G+ + AD + + ++ TVT + +EF D I+E + Sbjct: 330 RAGAMLLAHIGYGKEADKLYQALDIC----TVTEKKLVITGRNTGATGAEFADYIMETI 384 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 282 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 85/420 (20%), Positives = 147/420 (35%), Gaps = 84/420 (20%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + E + + GD IG ++ LK++ E+ + +IS+ G S G Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISY--GLIGGASLDKTG--S 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQG 136 + E L+ + G + P + LRQ LD + +RP R+Y Sbjct: 57 AITDEVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYAS 116 Query: 137 T---PSPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + SP+K D V+ REN Y G + + + Sbjct: 117 SLLNQSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA-------------------- 156 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS---------VTLVHKGNIMKFTEGAFK 242 +R R + A R V K N++ + ++ Sbjct: 157 -----------RTEVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL-ASGRFWR 204 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIAC 301 + + EF +I + D +AD+ ++ P +++ VI Sbjct: 205 TVTHDIFEREF-------------------PDIELHDQLADSMAMVMVKAPTKFNGVIHT 245 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPG 354 N GD +SD VG +G+ P A++ ++EA HG+AP +G + NP Sbjct: 246 DNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSAPDISGTGQANPI 305 Query: 355 SIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + ILS M+LR+ ADL+ + + + R D + GDA+ Sbjct: 306 AQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 74/392 (18%), Positives = 149/392 (38%), Gaps = 58/392 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDGIG ++ ++K+V + KI+ + Y G S + + Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSC----IYTGYKINIIYNYIGGISIDKFNTP--ITN 55 Query: 87 ETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +I+ G + + LR++ + + +RP++ P K Sbjct: 56 NLISIIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D++I RE + IY G + P K + Sbjct: 110 ---NIDIIIVRELNGGIYYGKPKGFSKQII---------------NQIPTWYAYNTKIYN 151 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ RL R + A+ + + + K N+++ T +K + + Sbjct: 152 EQEIIRLARISFNLALNR-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFY---------- 199 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + + D ++ ++DVI NL GD ISD + G +G+ Sbjct: 200 ----------NKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGM 249 Query: 323 APGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGM 380 P +I ++ +LFE HG+AP A ++ NP +LS MM + + + ++ + + Sbjct: 250 LPSISINNKSLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYVLNDFKLSNNLYYSI 309 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 ++ T D ++ + K++ EFGD + Sbjct: 310 YKVLSYGFCTIDMKKYIRNFKIVSTEEFGDLV 341 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 108/396 (27%), Positives = 154/396 (38%), Gaps = 64/396 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V L V+DA + + G+ L Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGS 72 Query: 88 TLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD IR A+ G + P G +R + LR ELDLY+ RP R + SP++ P Sbjct: 73 DLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDP 132 Query: 145 --ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D VI REN+E +Y+GI G + PE + + + Sbjct: 133 ARRAIDCVIVRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLST 173 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G R++ A A R SV LV K N ++ ++ + Sbjct: 174 RHGVSRVLEFAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVAR----------- 218 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 I + D ++ P +DVI N GD +SD AA GG+G+ Sbjct: 219 ---------HPHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDILSDLTAALAGGLGV 269 Query: 323 APGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 A AN+ ALFE HG+AP AG NP ILS ++ H+G E AD + + + Sbjct: 270 AASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAEHLGRNEEADAVRRAV 329 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ A VT D L E G A++ + Sbjct: 330 AAAVAAGRVTPDL------GGPLGTKEVGAAVLAEL 359 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 278 bits (711), Expect = 3e-73, Method: Composition-based stats. Identities = 86/406 (21%), Positives = 163/406 (40%), Gaps = 61/406 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG +V +KV+ ++ + ++ G + G P Sbjct: 3 TYNIALLAGDGIGPEVMKEAVKVLKLIEQR--NEDVNFELNDVLFGAAAYFAMGH--AFP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG---------IRSLNVALRQELDLYICLRPVRYYQG 136 ET + +KG + R + LR+ + + RPV +G Sbjct: 59 DETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKG 118 Query: 137 TP--SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 SP+K E D++I RE +Y G + +AD ++ ++ + E Sbjct: 119 LAHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLE---------- 168 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E+ +++V+ E ++ + + +HK N++K + + + + ++ Sbjct: 169 ---------YDEDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKN 217 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 E+ +K+++ DA + L P +DV+ N+ GD +SD Sbjct: 218 Y--------------------PEVEVKNILVDAAATYLCLNPGMFDVMVMENMFGDILSD 257 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGWT 370 +G +G+ P A G + + +E +HG+AP AG+ NP S+I S +ML G Sbjct: 258 QGGGILGSLGLMPSACKGPDKSYYEPSHGSAPDIAGKGIANPYSMIGSVALMLEMSFGLE 317 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A + M+ T D + + A L+ +EFGD + + Sbjct: 318 KEAKNLWAAMQAVFENGYSTSDLSKEGE-ANLVSTAEFGDLVCAEL 362 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 277 bits (707), Expect = 8e-73, Method: Composition-based stats. Identities = 91/387 (23%), Positives = 152/387 (39%), Gaps = 48/387 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ P + +V + +++ + G + + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDP-------SVNFTFYNISSERYINKG--ITIKDSE 54 Query: 89 LDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 +D ++ Y G + G + + + LR+ELDLY+ +RP + Sbjct: 55 IDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----N 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 M I REN ED Y+ I + + + + S + Sbjct: 110 NIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKN 169 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 KR A + A D ++VT+ K N + +++ + Sbjct: 170 LKRFFNMAYKIA---DTETVTITDKANAVDMYS-LWREIAIE------------------ 207 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + I AD+ ++ P +Y I NL GD +SD +A VGG+G AP Sbjct: 208 ---ESEPAGKKINFEYADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPS 264 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 NIGD ++FE HG+AP AG++ NP + ILS MML+H+ TE A ++ K +E I Sbjct: 265 GNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVENVIR 324 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAI 412 T+ ++ EF + + Sbjct: 325 NGTI------PIESGGNAGTHEFINKV 345 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 271 bits (694), Expect = 3e-71, Method: Composition-based stats. Identities = 93/399 (23%), Positives = 156/399 (39%), Gaps = 65/399 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + G GIG ++ L+V+ AA +S+ K Sbjct: 32 SKYGGKTNVTILTGSGIGPEIMDHTLRVLKAA-------GAPLSYEIFALSSKDGSKNND 84 Query: 81 DVWLPAETLDLIREYRVAIKGPLT-TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 E L IR RVA+KG + I+S N+ R+ LDL++ + + + G Sbjct: 85 F----DEALTSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLS- 139 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+ + R+N+E Y +E + + E +K Sbjct: 140 --NKFGEIDITVIRQNTEGEYLMLEHEPRTGSVE-----------------------SLK 174 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + +RL+ A +YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 175 VLTRFNLERLIEFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSY------- 227 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 I + + + + +I P +DVI NLNG IS+ L +GG Sbjct: 228 -------------PMIKMNVLDVNVAIFKIASNPRIFDVILATNLNGSMISNYLNGMLGG 274 Query: 320 IGIAPGANIG-DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G+ G N D A+FE G ++ NP ++I+S +L H+G+ + A++I Sbjct: 275 PGLTSGINFSADGIAVFEPGARNKGSSIVGLNRANPIAMIMSGINLLHHLGYNKTAEMIH 334 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + YD R D E D II ++ Sbjct: 335 NSVYATL-----VYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 102/422 (24%), Positives = 165/422 (39%), Gaps = 78/422 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++T A ++ E +I W + + +G V P E Sbjct: 16 RITLLPGDGIGPEITDACRGLIADVFPHWELTETQIGWSQ-------WRAHGNPV--PQE 66 Query: 88 TLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVR 132 T + + A+ +T+ G RS + LRQ LDL+ +RPV Sbjct: 67 TWETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV- 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAG------IEWKADSADAEKVIKFLREEMGVK 186 G + D I REN+E +Y+ + ADS + + + + Sbjct: 126 TLPGAAA--------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVAR 177 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND--------RDSVTLVHKGNIMKFTE 238 + + ++ + RL R A + A+A +VT+ K NI++ + Sbjct: 178 AVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSA 237 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 + ++A E ++ ADA Q++ PA +DV Sbjct: 238 RVIRGAVEEVAEEY--------------------PQVAFDFANADAVAMQLVTDPARFDV 277 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIIL 358 I NL GD +SD A +GG+G+A AN+GD A+FE HG+AP AG+ NP + +L Sbjct: 278 IIAENLIGDILSDIGAGLIGGLGLAASANVGDNFAVFEPVHGSAPDIAGRGIANPAAFLL 337 Query: 359 SAEMMLRHMGWT----EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 SA M H+G A + + + A +D SEF A+ Sbjct: 338 SAAMCAEHLGAPVSELAPAAKLREAVYAATR-------TAPTLDLGGTATTSEFVAAVRA 390 Query: 415 NM 416 + Sbjct: 391 EL 392 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 267 bits (682), Expect = 6e-70, Method: Composition-based stats. Identities = 85/396 (21%), Positives = 151/396 (38%), Gaps = 61/396 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I G+GIG +V A LK++ + + + G + + G + P Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAK---IQGFTLQVDYGWLGATAFEQLG--SYFP 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRY----YQGTPSPV 141 T +L + G ++ + + LR+ D + LRP+R + Sbjct: 63 QATTELCDGADGIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRP 115 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + D++I RE IY G ++ + G Sbjct: 116 EKIQGLDILIVRELVSGIYFGPSGRSSDE--------------------RGNYGYHTMRY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +E +R+ R A+E A R +T+ HK N + + + A + Sbjct: 156 YDEEIRRIARKALEQAQYR-RGLLTVAHKENALPHLH--WTRLVQEEATKF--------- 203 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++++ ++ D Q++L P +DVI NL GD +SD A VG IG Sbjct: 204 -----------PNVIVEPMLVDNLAMQMVLNPQRFDVILASNLFGDILSDIGGALVGSIG 252 Query: 322 IAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 + A++ L+EA HGTAP AG NP + + +ML+ G +AA I+ Sbjct: 253 LLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLGACVLMLQQWGEVQAAQQIIAAQ 312 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + L+ + D ++E + Sbjct: 313 DRILAKGYRTADLFTQGEEI-LVNTATLVDLLLEEL 347 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 263 bits (673), Expect = 6e-69, Method: Composition-based stats. Identities = 91/407 (22%), Positives = 155/407 (38%), Gaps = 67/407 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDGIGVDV A + V++ A++ + + EI G + G + + Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAP--RYDEIQAGAGYFKETG--LDIEDG 57 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + G + P G S ++ LR LY +RPV+ Y P + Sbjct: 58 GEERAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLAD 117 Query: 144 PE--LTDMVIFRENSED-IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+VI RE++E Y+ + + + + Sbjct: 118 PRAAGIDLVILRESTEGLFYSAAAH-------------------KRSLVVNDDEVQDVLR 158 Query: 201 CSEEGTKRLVRAAIEYAIAND----RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + + T +L R A A +T V K N+ + F+ ++ E Sbjct: 159 ITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSEF---- 213 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + DA ++ +P E+DV+ N+ GD +SD Sbjct: 214 ----------------ADVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGDILSDLAGGL 257 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT------ 370 VGG+G+A IGD LF+ HG+AP G+DK NP + ILSA +ML ++ Sbjct: 258 VGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYLAEKLDKPSL 317 Query: 371 -EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA+LI +E + R ++ + ++ + Sbjct: 318 ADAAELIDSAVETGFWHNAL-----RPIEFGGDMGTRAVTKELLGRV 359 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 263 bits (673), Expect = 7e-69, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 143/278 (51%), Gaps = 34/278 (12%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDG G ++ A +V++A W G + G LP Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E Sbjct: 54 SVLESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF---EN 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + + ++ +L ++ E GI IKP S G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRP--NALIKEPGGISIKPMSVPGS 168 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEY-------------- 214 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 +I D I D Q++ +P YDV+ NL Sbjct: 215 ------PDIEFDDRIVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 263 bits (673), Expect = 7e-69, Method: Composition-based stats. Identities = 100/411 (24%), Positives = 155/411 (37%), Gaps = 86/411 (20%) Query: 42 TPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAI 99 LKV+ A E I W ++ G + G W P++ + + Sbjct: 1 MREGLKVLHAVSEP-----LGIEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLIL 54 Query: 100 KGPLTTPVGGGIR-------------SLNVALRQELDLYICLRPVRYYQGTPSPVK---- 142 G + P G S + R L+LY +RP++ Y G + Sbjct: 55 LGAVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHK 114 Query: 143 ---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 DMVI REN+E +YA K I + Sbjct: 115 QIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKA-------------------DVAIDTR 155 Query: 200 PCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 156 VITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEY 214 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 EI I DAF Q ++ +P YDV N+ GD ++D Sbjct: 215 --------------------PEIEKDTAIVDAFTQWLVGQPEYYDVCVTSNMFGDIVTDL 254 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + GG+G+A G NIG A+FE HG+APK+AG+DKVNP ++ILS + L + + Sbjct: 255 ASTLQGGMGMAVGGNIGKHNAMFEPIHGSAPKHAGKDKVNPIAMILSVKEGLEWLAARKD 314 Query: 373 ADLIVK-------GMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + K + + T+TYD + KCSE G AI E Sbjct: 315 DATLTKAAEAIEAAVVEVLEKGETLTYDLVG---NDRASKCSEVGSAIAEA 362 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 73/423 (17%), Positives = 143/423 (33%), Gaps = 90/423 (21%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 ++ + P+ + ++GD IG +V +L + D K+ E G Sbjct: 3 RSSGKDAPKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSH---FGIKVETFERLIGGSCLD 59 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRP 130 + + TL E + G + P + + +R+ L+LY +RP Sbjct: 60 QHDCP--IQESTLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRP 117 Query: 131 VRYYQGTPSPVKHP-----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 + + +++ REN+ IY G + + D Sbjct: 118 AKIISERQLELSSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH------------- 164 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 +AA+ A ++ + V K N+M T ++ Sbjct: 165 -------------------------KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVV 198 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNL 304 + R+EF + + + D+ + P + + V+ NL Sbjct: 199 TETIRDEFPQLMD-----------------KLSHQLVDSAAMLLAKDPRKLNGVVLTENL 241 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDEC----------ALFEATHGTAPKYAGQDKVNPG 354 GD +SD + G +G+ A I +++ G+AP AG+ NP Sbjct: 242 FGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIANPI 301 Query: 355 SIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + +S +M R +G +AAD I ++ + + T D L + G A+ Sbjct: 302 GMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV------GGTLSTQQAGSALR 355 Query: 414 ENM 416 +++ Sbjct: 356 QSI 358 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 103/423 (24%), Positives = 169/423 (39%), Gaps = 79/423 (18%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 P + L ++ + + GDGIG + L+V ++ K+ + Sbjct: 34 QAPGRKDFKKL--------DHITVGILPGDGIGPCIMEQALRVAKYLLKDEMASG-KVEF 84 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQE 121 I G + ++ LPAE L+ + V +KGP TP + S N LR+ Sbjct: 85 RTIP-GMTIEERVQKNESLPAEVLEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRA 143 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RPVR + + D FREN E Y Sbjct: 144 LQLYAAVRPVRIPE---------KGIDWTFFRENIEGEYI-------------------- 174 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 G K I+ + + K + G +R+ RAA E+A N + +VT+V K NI+K +G F Sbjct: 175 -WGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNF 233 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR--PAEYDVI 299 + L +E I +++ + D+ +I + V Sbjct: 234 LKTAHALEKEY--------------------PGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD ++D A GG+G A +NIGD+ ALFEA HG ++ +P S+ Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQYALFEAIHGVGNFLVQHNRAQYADPCSL 333 Query: 357 ILSAEMMLRHMGWTEAADLIVKGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 I + M+ H+G+ E + +VK ++ +T D + EF D ++ Sbjct: 334 IRAMGEMISHIGYPEKKEQLVKALDICTRTERKVVITTDKDG-------ATAEEFTDYLL 386 Query: 414 ENM 416 + + Sbjct: 387 DTL 389 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 259 bits (661), Expect = 2e-67, Method: Composition-based stats. Identities = 103/399 (25%), Positives = 164/399 (41%), Gaps = 70/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +++G G+G D ++ ++ AA + + G + + LP Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK-------VPVEFEVHLAGRMALEH--GKDALPKA 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICLRPVRYYQGT 137 T D IRE +A+K L P G G + NVA R++L L+ +RPV G Sbjct: 54 TFDAIRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGI 113 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 PS D ++FRE +ED+Y E + + Sbjct: 114 PSRFT---GVDFLLFREITEDLYTASEHEIVPGVVQ-----------------------S 147 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 K +E R + A + A R +V +HK NI+K +G F + Y++A+E Sbjct: 148 FKIVTEAACLRFFKLAFDTARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEY----- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 EI KD+I D Q++ RP +++V+A NL GD +SD A V Sbjct: 203 ---------------PEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGAGLV 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+ N G+ ++EA +G + + D NP +IL A +L+ +G T A I Sbjct: 248 GGVSTTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETGTAGRIQ 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E + + R D + F DAI+ M Sbjct: 308 KAVETVLLEGRI-----RTRDIGGTATTTAFTDAIVSRM 341 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 258 bits (658), Expect = 3e-67, Method: Composition-based stats. Identities = 93/363 (25%), Positives = 153/363 (42%), Gaps = 52/363 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG ++ P + + + I+++ + G + + + Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS--------DINFVTFDISSERYIKTG--IIIKDDE 53 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 L+ ++ YR + G + P G + + + LR+EL+LY+ +RPVR + + Sbjct: 54 LEELKNYRAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------D 104 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 + I REN++D Y I + V E G G+ Sbjct: 105 KIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGML-------- 156 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R ++ A + +VT+ K N +K ++ + A E Sbjct: 157 SYRYLKKFFNKAFSICDSTVTVTDKANAVKMYN-LWRSTAMEAAIE-------------- 201 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 K I I ADA ++L P +Y I NL GD ISD AA VGG+G AP Sbjct: 202 -------KNINISFEYADALAYNMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPS 254 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIGD+ ALFE HG+AP AG+D NP + I++ M+L ++G+ + + +I + Sbjct: 255 ANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYLGYRDESRIINDMVRNLYI 314 Query: 386 AKT 388 Sbjct: 315 NGV 317 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 251 bits (640), Expect = 4e-65, Method: Composition-based stats. Identities = 102/355 (28%), Positives = 160/355 (45%), Gaps = 38/355 (10%) Query: 47 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 106 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGE-----DQQGLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 107 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSGK---RIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 VH+ + M T+G F + +A+E +I D + Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQEF--------------------PDIAFADRSIEVIC 222 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 Q+++ +P +DV+ NL GD ++ A VGG+ + P A++GD+ A+F T Sbjct: 223 QELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVF-GAQSTGTDDV 280 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 G D P S+IL+ +MLRH+G EAA + +E + + T + Sbjct: 281 GHD---PTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVDTTADLNPVGFEG 332 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 250 bits (638), Expect = 8e-65, Method: Composition-based stats. Identities = 100/407 (24%), Positives = 162/407 (39%), Gaps = 109/407 (26%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V PA ++++A K + +++ G ++ + G L Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEAL---PSYLGLKFEFTDLHAGFETFERTG--AAL 58 Query: 85 PAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P +T++++R E A+ G +++P G S VALR++LDLY +RPV+ + Sbjct: 59 PDKTVEILRNECDGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTV------L 112 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + DMVI REN+ED+Y E D+ D + IK Sbjct: 113 SAAKPIDMVIVRENTEDLYVKEETTRDTPDGK--------------------VAEAIKRI 152 Query: 202 SEEGTKRLVRAAIEYAIANDRDS------------VTLVHKGNIMKFTEGAFKDWGYQLA 249 SE + R+ A + A+ + VT+ HK N++ Sbjct: 153 SERASHRIATMAGDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL--------------- 197 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 + +K+VI D NL GD + Sbjct: 198 -------------------------LRLKNVIVD------------------PNLYGDIL 214 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD AA VG +G+ P AN+G+ A+ E HG+AP GQ+ NP + + SA +ML + Sbjct: 215 SDDAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIMGQNIANPIATLRSAALMLEFLDE 274 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I ++ + + D K +E + I+ + Sbjct: 275 EAAAAKIYAAVDANLTEGKL-----LSPDLGGTAKTTEVIEDILRRL 316 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 249 bits (636), Expect = 1e-64, Method: Composition-based stats. Identities = 83/375 (22%), Positives = 139/375 (37%), Gaps = 68/375 (18%) Query: 42 TPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 A+ +V+ A I W + E L +R +V IKG Sbjct: 1 MDAVQEVICAVKA-------PIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKG 48 Query: 102 PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYA 161 P+ + R +R++ + + + +G SP D+VI R+ E Y+ Sbjct: 49 PVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYS 99 Query: 162 GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND 221 GIE + IK + G R+ YA+ N Sbjct: 100 GIEHLVVPGVMQT-----------------------IKVSTTAGAARIAEFVFNYAVKNK 136 Query: 222 RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVI 281 R +T+ HK NIM+ T+G F + A + +++ ++ Sbjct: 137 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVD-------------------DVLFEERY 177 Query: 282 ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGT 341 D + +ILL+P + DV+ ++ GD + +G GI PG ++ +F+ Sbjct: 178 LDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKA 237 Query: 342 APKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 AG+D NP +LSA +MLRH+ + AD + + D R D Sbjct: 238 CHALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGG 292 Query: 402 LLKCSEFGDAIIENM 416 KCSEF A+ + + Sbjct: 293 KAKCSEFVKAVCDCL 307 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 248 bits (634), Expect = 2e-64, Method: Composition-based stats. Identities = 97/403 (24%), Positives = 164/403 (40%), Gaps = 73/403 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDGIG + A L V ++K +R + ++ I G + Q+ LP Sbjct: 38 VKVGIMPGDGIGPYIMKAALLVARKLLKKEIADQR-VEFVPIK-GMTIEERARQNKSLPP 95 Query: 87 ETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 L+ + + +KGP TP + S N LR++L LY +RP+R + Sbjct: 96 AVLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE------- 148 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D FREN E Y G K I + I K S Sbjct: 149 --KGIDWTFFRENIEGEYI---------------------WGNKGICVGDDLAIDFKILS 185 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 + G +RL R A EYA ++ + ++T+ K NI+K +G F + + +E Sbjct: 186 KPGAERLFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEY---------- 235 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPA---EYDVIACMNLNGDYISDALAAQVGG 319 I +++ + D+ +++ P V NL GD ++D A GG Sbjct: 236 ----------PGIHVREELIDSLSAKLM-DPEFNAGMQVFVLPNLYGDILTDIAAEYQGG 284 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLI 376 +G A +NIGD+ A+FEA HG ++ +P S+I + M+ +G+ E D + Sbjct: 285 LGTASSSNIGDQYAMFEAIHGVGVYLVEHNRAQYADPSSLIRAMGEMMAFIGYPEKRDRL 344 Query: 377 VKGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ +T D + EF + ++E + Sbjct: 345 FKALDFCTKVERKAVITTDKDG-------ATAEEFAEYVVETL 380 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 247 bits (630), Expect = 6e-64, Method: Composition-based stats. Identities = 95/433 (21%), Positives = 162/433 (37%), Gaps = 98/433 (22%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 E+ + + GDGIG +V A ++A + E+ + + Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEAL------PGPALVLTELGWPAHAWHR-DHGEMM 58 Query: 85 PAETLDLIREYRVAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRY 133 PA+ + Y + G L P G + + LR+ LDL+ C RP Sbjct: 59 PADWRGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVP 118 Query: 134 YQGTPSPVKHPELT--DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 G P P+ P D+++ RENSE Y ++ G P Sbjct: 119 LAGAPMPLSDPRALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTP 159 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS-------------------VTLVHKGN 232 ++ + GT+R++R A E A + V +V K N Sbjct: 160 RETATQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRN 219 Query: 233 IMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR 292 +++ + + ++A E I + DA + + + Sbjct: 220 AVQYAGELWSEVFAEVAAEY--------------------PGIATHHELIDACCMKFVSQ 259 Query: 293 PAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE----CALFEATHGTAPKYAGQ 348 P ++DV+ NL+GD ++D A GG+G+AP AN+ LFE THG+AP AG Sbjct: 260 PWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGA 319 Query: 349 DKVNPGSIILSAEMMLRHMGWTE-----AADLIVKGMEGAINAKTVTYDFERLMDGAKLL 403 D+ +P +++L+A ML MG + +A + + + I G Sbjct: 320 DRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE-----------HGMGGR 368 Query: 404 KCSEFGDAIIENM 416 C+E G A+ + + Sbjct: 369 GCAEVGRAVAQRI 381 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 246 bits (628), Expect = 1e-63, Method: Composition-based stats. Identities = 113/404 (27%), Positives = 198/404 (49%), Gaps = 39/404 (9%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + + VP+ I YI+GDGIG ++T AM+ VV++A+E AY+G R I W +I G Sbjct: 10 YIEFTDSGMVVPDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGT 69 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + +G ++P +++ I++ +A+K L R LN LR+ L LY +R ++ Sbjct: 70 EAYEKFG--TYVPEDSIKEIQKMYIAMKSTLNF--MPDKRDLNTILRKRLGLYSNIRILK 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 Y +G PV ++ I R+++ + + + S + +I+F+ + G + Sbjct: 126 YIEGMDIPVNTFNRLNLTIIRDSTPNSHI---FYHSSESTDDLIRFISDNYG---LNITP 179 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 GI + P S+ T+++ + A+ Y+ N + +T++ F +W + A Sbjct: 180 DSGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEA--- 231 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + +++ + + F+++++ P +++VI N+ + D Sbjct: 232 -----------------SAQEDVGYEVLKTREFMKRLISSPEDFEVILVDNVLSQTLVDY 274 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 LA G I I G++IGDECA+FEA + P AG D +P S ILS ML H+GW EA Sbjct: 275 LA---GTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEA 331 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + A + D D +KCSEF II+ M Sbjct: 332 AQIIENAISAAFRDNKIPKDINTRPDI-SPIKCSEFSSEIIKRM 374 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 244 bits (622), Expect = 6e-63, Method: Composition-based stats. Identities = 76/347 (21%), Positives = 135/347 (38%), Gaps = 55/347 (15%) Query: 48 VVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV 107 ++++ V+ + I W + + + + + L+ + ++ IKGP + Sbjct: 1 MIESLVKVFSTVQVPIDWDVFH---EHKINSAEGEDVSPKLLESLCRNKIGIKGPFESGP 57 Query: 108 GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167 LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 58 C------LRKLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRV 108 Query: 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTL 227 + IK + EG R+ R EYA N+R +T+ Sbjct: 109 VPGVMQT-----------------------IKVSTAEGADRMARYVFEYAKKNNRKKITV 145 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 HK NIM+ T+G F + A + +I+ ++ D Sbjct: 146 AHKANIMRLTDGTFLSPMRREAAKY-------------------QDDIMFEERYLDTVCL 186 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAG 347 +L++P DV+ ++ GD ++ A+ +GG + PG +G ++E T AG Sbjct: 187 AMLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPGFAVGPMGLIYEPIIHTNTNIAG 246 Query: 348 QDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA-KTVTYDF 393 +D VNP ++LS +MLR M E AD I + T D Sbjct: 247 KDIVNPTGMLLSGVLMLREMKLNEYADKICCAVSTVFRETDCRTKDL 293 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 241 bits (614), Expect = 4e-62, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 143/420 (34%), Gaps = 68/420 (16%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 ++L+NG I I GDG+G ++T + + A E R + E G Sbjct: 3 DIVSLRNGS----RIYTIALIPGDGVGPEITREAVLTLKRAGE---VYGRSFQFTEAIAG 55 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLY 125 + LP E+L E + G L G S+ LR L L Sbjct: 56 TAALDR--GQCPLPRESLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLR 113 Query: 126 ICLRPVRYYQGTP--SPVK---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +RP + + P+K + D++I R+ + ++ Sbjct: 114 SDIRPCFFAEALRELCPLKEEIRKKGMDILIIRDIAGGMFT------------------- 154 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 G + E + R A + A + R VT + K I+ + Sbjct: 155 -TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQLAASRKR-KVTSLDKA-ILLSSSVL 211 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 ++ + R+ EI ++ ++ D +++ P +DVI Sbjct: 212 WRQILEETHRDY--------------------PEIELEHMLVDHGAFKLVSSPDAFDVIV 251 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEA--THGTAPKYAGQDKVNPGSII 357 N+ GD I+D A G P ++ + ++ H + AG + NP +I Sbjct: 252 ASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPVGMI 311 Query: 358 LSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L+A MML + G A+ + + + + G + + G+A+ E + Sbjct: 312 LAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGRP--CWSGGEQTADTAAIGEAVRECL 369 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 236 bits (602), Expect = 1e-60, Method: Composition-based stats. Identities = 78/423 (18%), Positives = 142/423 (33%), Gaps = 77/423 (18%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 Q + G + IEG G G V A+ K+ AA+ + W Sbjct: 24 QCGSLVSGAGNGKAQRPIRVTVIEGQGTGPVVLAAVRKIFKAAL-------VPVEWDYQT 76 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICL 128 + P LD E + + ++P + S ++AL + L+ ++ + Sbjct: 77 LSVYRDHKTNRMTVNPQ-LLDSAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGV 135 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 R G + ++V RE+ Y+ IE + Sbjct: 136 RKFNSVVG----HEPYGPINLVNIREHVSGEYSEIEHLVSPGVVQ--------------- 176 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 IK S++ + + + A +YA + +T++HK ++M+ ++G F ++ Sbjct: 177 --------SIKTVSKKISVEVAKLAFDYACKHGHSRITVLHKADVMRLSDGIFLKACREV 228 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + ++ + D+F + P Y+V+ +L G + Sbjct: 229 SACY--------------------PDVEYNEEKLDSFCLNVTTNPGRYEVLLTTSLYGAF 268 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEA---------THGTAPKYAGQ------DKVNP 353 GG+ P G + +F +H + +NP Sbjct: 269 AGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYGQEQIINP 328 Query: 354 GSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 II +A +ML H G A I +E I T D CS+F DAII Sbjct: 329 TGIIRAAALMLDHAGMVVAGRCIAAAVEDTIRQGIRTQDM------GGDASCSQFTDAII 382 Query: 414 ENM 416 +N+ Sbjct: 383 KNL 385 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 234 bits (596), Expect = 5e-60, Method: Composition-based stats. Identities = 86/416 (20%), Positives = 142/416 (34%), Gaps = 78/416 (18%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I DG+G DV P K + A E G ++ G + G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQE--ILGGFELDCRYYEAGVEYAVKTGK--MC 57 Query: 85 PAETLDLIREYRVAIKGPLTT----------PVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I + + G P + LR + I LRP+R Sbjct: 58 EDNLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLR 117 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 +G P+++ E D+++ R+ +E Y E Sbjct: 118 KGIDCPLRNREEIDVLLVRQLAEGFYIRPGH-----------------------MIGEDA 154 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHK-GNIMKFTEGAFKDWGYQ 247 + T++ A + VTL +K GN+ F ++ + Sbjct: 155 AYDTIVVTRNVTEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCF--DFYRKIFTE 212 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 ++ +I ++ DA + ++ P +DVIAC N+ GD Sbjct: 213 VSAGY--------------------PDIGLQFTQVDALAEHLIKDPDRFDVIACENMIGD 252 Query: 308 YISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 I D A GG+GI P A++G F HGT P+ G+ NP + IL+A ++L + Sbjct: 253 IIGDIGAYITGGMGITPTADVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTL 312 Query: 368 G-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G A LI K +E + T R D +A+ + M Sbjct: 313 GNERGDDNLRRGARLIEKAVEYNL-----TTGGPRTKDLGGTANTFATAEAVFKAM 363 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 233 bits (595), Expect = 7e-60, Method: Composition-based stats. Identities = 93/397 (23%), Positives = 150/397 (37%), Gaps = 71/397 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGI +++ A+ V DA +I ++ + ++S + G + Sbjct: 7 NRYSIVELHGDGIARELSQAVHTVADALP-------FEIEFIPVDLSDESREAKGD--AI 57 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E +R Y ++K P T S N LR+ + + RPV G + + Sbjct: 58 YDEAEAAMRRYGTSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQT--HYN 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E + I R + Y R + I+ Sbjct: 112 ERIHLDIVRIATGGTY-----------------------EDAGRRINRDTAVSIRAIERR 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 + R A A D +V K I K T+G F++ +AR+ Sbjct: 149 PSVLASRFAFRLAQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDY------------ 195 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + DA L I++RP Y VI C N GD++SD +G IG+ Sbjct: 196 --------PATEFREELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGLIGSIGLGD 247 Query: 325 GANIGDE------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 A+ + A+F+ GTAP AGQ+K NP + +L+ MLRH+G +++ + Sbjct: 248 SASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAMANMLRHIGEHDSSKALRG 307 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + GAI A T D L SEF I++ Sbjct: 308 ALFGAIEAGEKTADI------GGSLNLSEFTQVIVDR 338 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 230 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 81/406 (19%), Positives = 147/406 (36%), Gaps = 56/406 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + E ++ + G+G+G +V L ++ E G+R G ++ + Sbjct: 18 RGTGTERGEAFLVGVLPGEGVGPEVIDVALSLLRLLGEA--TGQRFEVRTGGPIGRQAER 75 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + G+ L E D + L P GG LR+ DLY L P+R++ Sbjct: 76 LTGRG--LTPEVRDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPA 130 Query: 137 TP----SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + D++I REN+ +Y G EW ++ A + Sbjct: 131 LADAGVLRPEAARSADVLIVRENASGLYCG-EWGSEGEGAAR------------------ 171 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R++R A+ A R + +V K + + D +A E Sbjct: 172 -SAYQVCRYRADEVERILRTALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGE- 228 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + + + D Q++ P ++DVI C N+ GD + D Sbjct: 229 -------------------HGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGDC 269 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 + +G G++ N G A+++ HG A AG+D+ NP + S MMLR Sbjct: 270 GSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLRESFRLP 329 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + + T D + + G A+ ++ Sbjct: 330 ALADALETAIARTLARGVRTADIQGA--QPTAVGTRAMGQALCASL 373 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 80/431 (18%), Positives = 147/431 (34%), Gaps = 66/431 (15%) Query: 25 ENPIIP--YIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + +E DG M +++ EK I G + Sbjct: 42 KRIKVAKPVVEMDG------DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRP-- 130 V + ++ ++Y VA+K TP + S N +R L + P Sbjct: 96 VTI--DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 153 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 + P + I R D Y ++ AD A K++ ++ GVK+ Sbjct: 154 CKNIPRLVPGWTKP----ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEV 209 Query: 191 PEHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247 G+ ++E + +YAI + + + K I+K +G FKD + Sbjct: 210 YNFPAGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQE 268 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 + + + + W + + D + Q+L + V AC N +GD Sbjct: 269 IFDKHYKTDFDKNKIW-------------YEHRLIDDMVAQVLKSSGGF-VWACKNYDGD 314 Query: 308 YISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILS 359 SD LA G +G+ + + EA HGT ++ + + NP + I + Sbjct: 315 VQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFA 374 Query: 360 AEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL-------KC 405 L H G + A ++ K + + +T D + G + Sbjct: 375 WTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNT 434 Query: 406 SEFGDAIIENM 416 ++F D I N+ Sbjct: 435 TDFLDTIKSNL 445 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 225 bits (573), Expect = 3e-57, Method: Composition-based stats. Identities = 157/219 (71%), Positives = 183/219 (83%), Gaps = 1/219 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + LNVP NPIIP+IEGDGIG+D++P M+KVVDAAV+KAY GE Sbjct: 3 YQKIQVPATGDKITVNADTSLNVPNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISWME+Y GEK+TQVY QD WLP ETLD +++Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+CLRPVR+++G PSPVK P DM IFRENSEDIYAGIEWKA S +A KVIKFL+ Sbjct: 123 QLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLK 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 219 EEMGV KIRF + CGIG+KP S+EGTKRL R A+ A A Sbjct: 183 EEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 223 bits (569), Expect = 8e-57, Method: Composition-based stats. Identities = 77/434 (17%), Positives = 143/434 (32%), Gaps = 66/434 (15%) Query: 19 GKLNVPENPII--PYIEGDGIGVDVTPAMLKVVDA-AVEKAYKGERKISWMEIYTGEKST 75 K++ + + P +E DG M +V+ A EK I M + Sbjct: 174 NKMSGFQRIKVDQPVVEMDG------DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHR 227 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYI 126 V + + I+ + V +K TP ++ S N +R LD I Sbjct: 228 DKTDDQVTI--DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTI 285 Query: 127 CLRPV--RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184 P+ + P ++I R D Y +++ D + ++ Sbjct: 286 FRAPILMKNVPRLVPSWTKP----IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSN 341 Query: 185 VKKIRFPE--HCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 + E G+ + ++ K + +YA+ + L K ++K +G F Sbjct: 342 PEVHEVYEFKGGGVALGMYNTDASIKGFAHSCFQYALDQKM-PLYLSTKNTVLKKYDGRF 400 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 KD + +E+ + + G W + + D + Q + + V AC Sbjct: 401 KDIFQTIYEKEYKQKFEEAGLW-------------YEHRLIDDMVAQAIKSSGGF-VWAC 446 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNP 353 N +GD SD +A G +G+ + + EA HGT ++ Q + NP Sbjct: 447 KNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTSTNP 506 Query: 354 GSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK-- 404 + I + L H E + + + A +T D + L Sbjct: 507 IASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIK-GDKLTDR 565 Query: 405 ----CSEFGDAIIE 414 +F D + Sbjct: 566 DYLCTEDFMDKLAR 579 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 221 bits (563), Expect = 4e-56, Method: Composition-based stats. Identities = 79/363 (21%), Positives = 129/363 (35%), Gaps = 75/363 (20%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V A +A E ++W V + Sbjct: 16 YKIAAIRGDGIGPEVIEAGNY--QSAEETNRVAWILLNWPSRTLSGA--------VRITR 65 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 T D+ P+++ S + LR + P R + G SP+ Sbjct: 66 NTADI---------SPISSSTFLWFSSY-LPLRSS---TSNM-PTRVFHGIQSPLH---- 107 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D VI RENSE YAG G P I + G Sbjct: 108 LDWVIVRENSEGEYAGHG-------------------GRSYAGKPWEVATDISIFTRHGV 148 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY-QLAREEFGGELIDGGPWLK 265 +R+++ A E A + + +T+ K N + + + ++A + Sbjct: 149 ERIMKFAFEAARSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQF------------- 195 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 ++ ++ DA +++L P D I NL+ +SD +A G IGIAP Sbjct: 196 -------PDVTCDKMLVDAMTARVVLTPESLDTIVPTNLHAGILSDLASALAGSIGIAPT 248 Query: 326 ANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 +N+ ++FE HG+A AG+D + ML +G AA +++ +E Sbjct: 249 SNLDPTRENPSMFEPVHGSAFDIAGKDLA----TFWTVAEMLSWLGQKGAAAELLECVES 304 Query: 383 AIN 385 Sbjct: 305 VCK 307 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 218 bits (554), Expect = 4e-55, Method: Composition-based stats. Identities = 80/431 (18%), Positives = 145/431 (33%), Gaps = 66/431 (15%) Query: 25 ENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + P +E DG M +V+ + +K ++ G Sbjct: 4 QKITVQNPIVEMDG------DEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDK 57 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRP-- 130 V + E+ + ++Y VAIK TP + RS N +R L+ + P Sbjct: 58 VTV--ESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIM 115 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR---EEMGVKK 187 + P + I R D Y + A K++ E+ + Sbjct: 116 CKNIPRLVPGWTKP----ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEV 171 Query: 188 IRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 F G+ + + + + R A++ A + + L K I+K +G FKD Sbjct: 172 YNFTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDIFQ 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++ + + + G W + + D + L Y V AC N +G Sbjct: 231 EVYEANWKSKYEEAGIW-------------YEHRLIDDMVAYALKSEGGY-VWACKNYDG 276 Query: 307 DYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYA------GQDKVNPGSIIL 358 D SD LA G +G+ + + EA HGT ++ G+ N + I Sbjct: 277 DVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIF 336 Query: 359 SAEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK------C 405 + L H + + + GA+ + +T D ++ L Sbjct: 337 AWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNT 396 Query: 406 SEFGDAIIENM 416 EF DA+ + + Sbjct: 397 EEFIDAVADEL 407 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 218 bits (554), Expect = 4e-55, Method: Composition-based stats. Identities = 75/404 (18%), Positives = 127/404 (31%), Gaps = 90/404 (22%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + E G S +V+ + Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAK 61 Query: 86 AETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVR-----YYQ 135 A + + G + P G + LR+EL Y LRP Sbjct: 62 ALAAAKAADAILL--GAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVD 119 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 +P TD ++ RE + IY G + D + Sbjct: 120 SSPLKADVCRGTDFIVVRELTGGIYFGARTEDDGSG----------------------FA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + S +R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 158 MDTDAYSRAEIERIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ + + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLEVGHQLIDSAAMLMVKSPRALNGVVVTSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 + G IG VNP ILS MMLR+ + + Sbjct: 258 SVIPGSIG--------------------------AGIVNPIGTILSVAMMLRYSLNLPKE 291 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + A++ T T D + DA++ + Sbjct: 292 AAAVEAAVRTALDNGTRTKDL------GGSAGTFQMADAVVVEL 329 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 214 bits (546), Expect = 4e-54, Method: Composition-based stats. Identities = 66/411 (16%), Positives = 138/411 (33%), Gaps = 58/411 (14%) Query: 43 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV--TKDAAEAIKKHNVGVKC 73 Query: 102 PLTTPVGGGIR---------SLNVALRQELDLYICL--RPVRYYQGTPSPVKHPELTDMV 150 TP + S N +R L + + S P ++ Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP----II 129 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV---KKIRFPEHCGIGIKPCSE-EGT 206 I R D Y ++ ++ + F E G+ + ++ + Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 + ++ + A++ + L K I+K +G FKD ++ +++ + W Sbjct: 190 EDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW--- 245 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + + D + Q + + + AC N +GD SD++A G +G+ Sbjct: 246 ----------YEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLGMMTSV 294 Query: 327 NIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGWTE------- 371 + + EA HGT ++ + NP + I + L H + Sbjct: 295 LVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAF 354 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLL------KCSEFGDAIIENM 416 A+ + + I A +T D + G + EF D + EN+ Sbjct: 355 FANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENL 405 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 213 bits (542), Expect = 9e-54, Method: Composition-based stats. Identities = 92/388 (23%), Positives = 149/388 (38%), Gaps = 52/388 (13%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +G+GIG ++ ++ V+ A++ + GE ++ + G ++ G+ V P E Sbjct: 8 RLGVWQGEGIGPEIVAPTVQAVELALQAS--GEATPEFVPLLLGREAINATGRIV--PEE 63 Query: 88 TLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 T + I I GP P G + + LR++ DL+ +RPVR G Sbjct: 64 TWETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGA-----V 118 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI REN+E +YA S D + + + Sbjct: 119 HPDLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAI--- 175 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 A +T+ HK N++ T G + A E Sbjct: 176 --------------AAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF----------- 210 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + ++ V DA +++ RP Y I N+ GD +SD G +GIA Sbjct: 211 ----------GVEVQPVHIDALCAELVTRPERYATIVAENMFGDILSDLAGGLGGSLGIA 260 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N + + +A HG+AP AGQ NP I+ SA ML +G+ +AA+L+ + A Sbjct: 261 GSINASESQVMAQAAHGSAPDIAGQGIANPAGIMNSAAQMLDSLGYPQAAELLEGAVREA 320 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDA 411 + K T D R A + D Sbjct: 321 VV-KAPTADLVREAAAADPETATPVADE 347 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 212 bits (540), Expect = 2e-53, Method: Composition-based stats. Identities = 78/402 (19%), Positives = 138/402 (34%), Gaps = 66/402 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P I + GD G ++ L+V+ +V + + +++ ++ + V Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIRQ-----PLQFLDYDLSLENRRATDNKVV-- 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E R+ +++K TP G + S N LR+ L+ + LR R Sbjct: 58 WEAAQAARDSGLSLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVY 117 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + I R +D Y EW+ + + S Sbjct: 118 SP--IAIVRMAVDDAYGSKEWRETTE-------------------NGDEIAYRTSKISRS 156 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 + + +YA + V K + EG FK+ A+ Sbjct: 157 TCRAVAEFTFQYA-KRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRY------------ 203 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 E+ + ++ DA +L E VI +N +GD +SD + G I + Sbjct: 204 --------PEVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDMVLQMYGSIAGSE 255 Query: 325 GANIGDECA-------LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT---EAAD 374 +G E + EA HGTAP G++ NP ++IL+ +L + +A+ Sbjct: 256 SLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLSYGRIPQAEKASR 315 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + + I T D + SEF D +I + Sbjct: 316 AIYESVFETIYEGKATPDL------GGQMTTSEFTDEVIRRV 351 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 211 bits (536), Expect = 5e-53, Method: Composition-based stats. Identities = 85/408 (20%), Positives = 140/408 (34%), Gaps = 68/408 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +PE I +EGD G ++ ++V+D + ++ + V Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGV 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ +R IK TP G + S N LR+E+D + +R R G Sbjct: 56 V--SDAAAAMRTCGFGIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIA 113 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + I R ED Y +W+ A A + + Sbjct: 114 GVHYP--ISIVRMAIEDAYGAKQWREGDAGAA------------------DEVAYRTEHV 153 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + + A A A + V K + EG K+ A Sbjct: 154 TRSTCRAVSEYAFRTARAM-QARVYGGPKWTVSPVYEGMLKEEMDAAAAR---------- 202 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILL-RPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + V+ DA ++ E V+ +N +GD +SD + G I Sbjct: 203 ----------HPDVAYEPVLIDATYAGLVSGAADEPLVVPALNRDGDCLSDLVLPMFGSI 252 Query: 321 GIAPGA------NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM------G 368 A N A+ EA HGTAP G+D NP +++L++ +LRH G Sbjct: 253 AGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVANPMAMLLASGAVLRHAAERGHPG 312 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ I + + AI T D +EF DA+IE + Sbjct: 313 AERASRAIYESVLEAIATGIKTPDL------GGHAGTTEFTDAVIERI 354 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 207 bits (526), Expect = 8e-52, Method: Composition-based stats. Identities = 69/403 (17%), Positives = 127/403 (31%), Gaps = 74/403 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDG+G +V +++ E+ G ++ G LPA Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTG----PWPVGARAAAETGD--VLPA 55 Query: 87 ETLDLIREYRVAIKGPLTTPV------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 TL + G + LR+ DL I +R Sbjct: 56 GTLAACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVR----------E 105 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + + ++ + R Y G + + D + + Sbjct: 106 IPFADGRELTVVRNLIGGSYGGADDRVLREDGSE--------------------AADVLR 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + E +V A + + V K N + T ++ +ARE Sbjct: 146 LTRERVAEVVHTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARE--------- 195 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 + I ++ D ++ DV+ L GD +SD A + G Sbjct: 196 ------------RGIEVEHRYVDRAAFELGSGAPVPDVLVTEGLLGDILSDLAAGRAGSP 243 Query: 321 GIAPGANIGDE-------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 + A++ LFE HG+AP+ A +D+V+P L+ +LRH T A Sbjct: 244 ALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPLGGFLALAALLRHFPATREA 303 Query: 374 -DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + + + + TYD +G + DA++ Sbjct: 304 GERVRAAVGAVLRSGPWTYDLV--PEGGAAASTGQVADAVLAA 344 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 60/377 (15%), Positives = 125/377 (33%), Gaps = 50/377 (13%) Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQE 121 G + V + E + I++Y V +K TP + S N +R Sbjct: 101 GIEYRDQTDDKVTV--EAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNI 158 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L + P+ P + ++I R D Y + +++ Sbjct: 159 LGGTVFREPI-VIPAIP-RLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPAN 216 Query: 182 EMGVKK--IRFPEHCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 F G+ + +++ + ++ + A+ + + K I+K + Sbjct: 217 GQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNTILKRYD 275 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 G FKD ++ E+ E G W + + D + Q++ + + Sbjct: 276 GRFKDIFQEIYEAEYKKEFDAKGIW-------------YEHRLIDDMVAQMIKSEGGF-I 321 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------ 350 +A N +GD SD +A G +G+ + + F EA HGT ++ + + Sbjct: 322 MALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQKGRETS 381 Query: 351 VNPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAI-NAKTVTYDFE---RLMDG 399 NP + I + L G + A+ + + + +T D + Sbjct: 382 TNPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKER 441 Query: 400 AKLLKCSEFGDAIIENM 416 + E+ A+ + Sbjct: 442 EAWVTTREYMAAVERRL 458 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 203 bits (517), Expect = 9e-51, Method: Composition-based stats. Identities = 79/395 (20%), Positives = 132/395 (33%), Gaps = 103/395 (26%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I +VT A+ +V+DA Y Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQAPVYFE-------------TYIIKGKNMN 40 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 L E +D IR+ +V + G + + GG R+ELDL+ L G PS Sbjct: 41 HLTWEVVDSIRKNKVCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS--- 90 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+V+ REN+E YAG E + E + Sbjct: 91 RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT----------------------MT 128 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + R+ + A EYA + R VT VH G K + F + ++A+ Sbjct: 129 KFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMY--------- 179 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + + + R + + I++ + GG Sbjct: 180 -----------PNITYNE--IASRETRAIRRHSNSKSLWA------IIANIASGVAGG-- 218 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + GD+ A+FE + NP +++ S+ MMLRH+ AD + + Sbjct: 219 -----SFGDDYAIFEQVGSVG------NHKNPVALLFSSVMMLRHLLLPLFADRLKTAVT 267 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I+ G E D++I N+ Sbjct: 268 RVISEGKC---------GNSNTTTQEVVDSVIANL 293 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 69/395 (17%), Positives = 128/395 (32%), Gaps = 68/395 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G + + + +D K+S + G L Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDF---GGVALAAGAGTAL 64 Query: 85 PAETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQG--TPSPV 141 P+ TL R+ + P G + LRQEL+ + +RPVR+ Sbjct: 65 PSTTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 142 KHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 PE+ D+ FR+ + +Y G +A + Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAG----------------------DDGEAYDT 162 Query: 199 KPCSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 P S + +R+ R A YA+ + V + K N+M T ++ + EF Sbjct: 163 TPYSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF---- 217 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 ++ ++ V+ D + P + +I N+ GD +SD Sbjct: 218 ---------------PQVPLRHVLVDTASMILSSDPLSLNGIILTENMFGDILSDQAGGI 262 Query: 317 VGGIGIAPGANIG--------DECALFEATH-GTAPKYAGQDKVNPGSIILSAEMMLR-H 366 +G + A + +FE + K G P I + +ML Sbjct: 263 LGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNPGGKTVG-----PLGSIQAVGLMLELS 317 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 +G ++ + K + ++ + R +D Sbjct: 318 LGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 193 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 58/182 (31%), Positives = 82/182 (45%), Gaps = 25/182 (13%) Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 + ++G F +A++ EI ++ D ++ P Sbjct: 112 RMSDGLFLRCVRDMAQKF--------------------PEIQFEEKYLDTVCLNMVQNPG 151 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 +YDV+ NL GD +SD A VGG+G+ P N+G ALFE+ HGTAP AG+D NP Sbjct: 152 KYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPT 211 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +++LSA MMLRHM AD I + I D KCSEF + I Sbjct: 212 ALLLSAVMMLRHMELNTYADKIERAAFETIKEGK-----YLTGDLGGRAKCSEFTNEICA 266 Query: 415 NM 416 + Sbjct: 267 KL 268 Score = 54.7 bits (130), Expect = 6e-06, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 21/57 (36%), Gaps = 7/57 (12%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 T + + I GDGIG +++ A+ K+ AA I W + Sbjct: 35 ATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDV 84 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 193 bits (489), Expect = 2e-47, Method: Composition-based stats. Identities = 76/439 (17%), Positives = 139/439 (31%), Gaps = 80/439 (18%) Query: 13 KITLQNGKLNVPENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIY 69 + + + + P +E DG M +V+ +K + Sbjct: 67 FASSSSSSSTGFDRVKVQNPIVEMDG------DEMTRVIWRMIKDKLIFPYLDLDIKYFD 120 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQ 120 G + V + E+ + +Y VA+K TP + RS N +R Sbjct: 121 LGILNRDATDDKVTV--ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRN 178 Query: 121 ELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 L+ + P K P + I R D Y + K+I Sbjct: 179 ILNGTVFREPILCLNIPRIVPGWKKP----ICIGRHAFGDQYRATDTLIKGPGKLKMIFV 234 Query: 179 LREEMGVKKIRFPE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMK 235 + ++ + G+ + + + + R +++ A A + + L K I+K Sbjct: 235 PEDGNTPLELDVYDFKGPGVALAMYNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILK 293 Query: 236 FTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAE 295 +G FKD ++ E++ + + W + + D + + Sbjct: 294 KYDGRFKDIFQEVYEEKWKQKFEEHSIW-------------YEHRLIDDMVAYAVKSEGG 340 Query: 296 YDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAG------QD 349 Y V AC N +GD SD + EA HGT ++ + Sbjct: 341 Y-VWACKNYDGDLSSD------------------GKTLEAEAAHGTVTRHFRLFQKGQET 381 Query: 350 KVNPGSIILSAEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK- 401 N + I + L H G + + + A +T D L+ G K Sbjct: 382 STNSIASIFAWTRGLEHRAKLDKNEGLLDFVHKLEGSCIETVEAGKMTKDLAILIHGPKV 441 Query: 402 ----LLKCSEFGDAIIENM 416 L EF DA+ +N+ Sbjct: 442 SREFYLNTEEFIDAVAQNL 460 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 68/417 (16%), Positives = 140/417 (33%), Gaps = 53/417 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P +E DG M +++ ++ + G V + Sbjct: 39 TTPLVEMDG------DEMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQVTV-- 90 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGT 137 ++ + + VA+K TP + S N +R LD + P+ +G Sbjct: 91 DSAEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRGI 149 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK--IRFPEHCG 195 P + + + R D+Y E + +++ + ++ F E Sbjct: 150 D-PCVKNWVRPITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGV 208 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + + RA ++A+A +D V K I K + FKD ++ ++ Sbjct: 209 VEGMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAA 267 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 G I + D + +++ + + AC N +GD +SD +++ Sbjct: 268 RFEAAG-------------IEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSS 313 Query: 316 QVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKV------NPGSIILSAEMMLRHMG 368 G + + +EA HGT ++ + N + I + LR Sbjct: 314 AFGSLAMMTSVLASPHGYWEYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRA 373 Query: 369 WTE-------AADLIVKGMEGAINAKTVTYDFERL--MDGAKLLKCSEFGDAIIENM 416 + AD + + I + +T D R+ ++ L F A+ E++ Sbjct: 374 ELDGLADLAAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDL 430 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 181 bits (460), Expect = 3e-44, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 111/303 (36%), Gaps = 62/303 (20%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 +N P I I GDGIG ++ + ++V+ AA + + ++ + G + + G Sbjct: 1 MNAPHALDIAVIPGDGIGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTG- 55 Query: 81 DVWLPAETLDLIR-EYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYY 134 + A TL+ IR Y +KGP+ P G L LR LD Y +RP+ Sbjct: 56 -SAMSAATLERIRTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALL 114 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G +P++ D VI REN+E +Y + Sbjct: 115 PGVDAPLRGT-AVDYVIVRENTEGLYLSRGRGVG----------------------NDRA 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 + G +R+V A E A VT V K N+++ + F++ ++ Sbjct: 152 CADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEV 210 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A ++ ADA ++ P +DV+ N GD Sbjct: 211 ATRY--------------------PQVEADHRYADAAGHDLVADPGRFDVLVMENFLGDI 250 Query: 309 ISD 311 +SD Sbjct: 251 LSD 253 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 71/422 (16%), Positives = 130/422 (30%), Gaps = 95/422 (22%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 P +E DG M +++ +K I G + V L Sbjct: 11 KVKNPVVELDG------DEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTL 64 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQ 135 + + I++Y V +K TP + S N +R L + P+ Sbjct: 65 --DAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIP 121 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR--EEMGVKKIRFPEH 193 P V + ++I R D Y + D+ +++ + + +K FP Sbjct: 122 AIPRLVPSWKQ-PIIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKGGKPEVIKVYDFPAE 180 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 G+ FKD ++ ++ Sbjct: 181 GGVAQT----------------------------------------QFKDIFQEIYEAQY 200 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 E G W + + D + Q++ Y +IA N +GD SD + Sbjct: 201 RKEFEAAGIW-------------YEHRLIDDMVAQMIKSEGGY-IIAMKNYDGDVQSDIV 246 Query: 314 AAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSIILSAEMMLR 365 A G +G+ I + F EA HGT ++ + + NP + I + L Sbjct: 247 AQGFGSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQKGRETSTNPIASIYAWTQGLI 306 Query: 366 HMGWTE-------AADLIVKGMEGAI-NAKTVTYDFE---RLMDGAKLLKCSEFGDAIIE 414 G + A+ + K + +T D D + + +E+ DA+ Sbjct: 307 KRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQGKKDRSAWVTTNEYLDAVER 366 Query: 415 NM 416 + Sbjct: 367 RL 368 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 179/404 (44%), Gaps = 52/404 (12%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I L L +P++ I YIEGDG G ++T AM+ V++A+E AY G + I W +IY G Sbjct: 2 YIKLDGNHLIIPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGR 61 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + YG+ +LP E+++ IR+ +KGPL++ + G +N+ +++ L+LY ++ + Sbjct: 62 EAYEKYGK--YLPRESIEDIRKTVFVMKGPLSSNING--HDININIKRILNLYTDVKCIT 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G E ++ IF + +++Y + DS D++ + ++L++ + Sbjct: 118 GLPGLS------EGKEIFIFSPSIDEVY---HFSYDSEDSDMLRQYLQQSFNIS---IGG 165 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 I +K S R+++ A + A + L ++ Sbjct: 166 DSDIFLKGTSRY---RIIKIASKIAEISS-------------------LYGIKRTLVADD 203 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + G + + EI + D + + +++ + I Sbjct: 204 YTGSHAPLWVYNTLNKMEMPVEIENLYNLYDEMTSE-----SRFNIFIPDSRLSSLIIKI 258 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + A+ GA +GD +LFE+ + G D +P S +L++ MMLR + + +A Sbjct: 259 INART-----FFGAILGDFISLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDA 313 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ + + + + LKCS+F DAI++ M Sbjct: 314 ALILRNALNSVYSDGILPASL----NLNNGLKCSDFIDAIVKRM 353 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 173 bits (438), Expect = 1e-41, Method: Composition-based stats. Identities = 59/443 (13%), Positives = 128/443 (28%), Gaps = 73/443 (16%) Query: 22 NVPENPIIPYIEGDGI-GVDVTPAMLKVVDAAVEKAYKGERKIS-WMEIYTGEKSTQVYG 79 + + P I I G ++T +++ + + + IS W K+ Sbjct: 72 STSDKPKIKAPPMVYIQGEEMTHYATQLL---LNQWIEPYFDISSWETFDLSCKARDDSD 128 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRP 130 + + ++ + K P TP ++ S N A+R+ + R Sbjct: 129 DATLI--DAVEAGKRIGAIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRD 186 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 + +G K+ ++ R Y G W ++ + Sbjct: 187 TIHIEGIELGYKNQ----VLFERHAVGGEY-GAGWNEVGEGTLLTTYIPKDGGAPFVVDK 241 Query: 191 PEHC----GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 + + + + L + + + +V K + K+ EG + Sbjct: 242 RDLTDKHNVCVVYHNPYDNVRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFW-ATMK 299 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++ + + E + G + + +I+DA Q++ +A N +G Sbjct: 300 RVFDDTYKDEFLKAGLLDRSGG-------ELTHLISDAATMQLIRWTDGGFGMAAHNYDG 352 Query: 307 DYISDALAAQVGGIGIAPGANIG--DECAL----FEATHGTAPKYAGQDKV------NPG 354 D ++D +A G +G D+ FEA+HGT NP Sbjct: 353 DMLTDQIAQVHRSPGFITSNLVGVSDDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPL 412 Query: 355 SII--LSAEM-------------------MLRHMGWTEAADLIVKGMEGAINAKTVTYDF 393 ++ L M M ++ + + + T D Sbjct: 413 GLVEALLGAMCHAAQLEYDAKPNDVEAKRMYEYVN--NFTNTLRMALHNTFRYGQGTRDM 470 Query: 394 ERLMDGAKLLKCSEFGDAIIENM 416 +F + + Sbjct: 471 CGP----TGFTTEDFIAKVAWRL 489 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 62/416 (14%), Positives = 121/416 (29%), Gaps = 61/416 (14%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 97 G ++T ++ ++ A + W E K+ V + ++ + + Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTA--WREFDLRAKNRDDTEDQVL--RDVIEAGKAVKA 73 Query: 98 AIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 K P TP ++ S N A+R+ + R + G K P + Sbjct: 74 IFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE 133 Query: 149 MVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 R YA G + + + + + Sbjct: 134 ----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNP 189 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 + L R + +V K + K+ E + ++ EE+ + +D G Sbjct: 190 YDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFW-QIMKKVFDEEYKSKFVDAGV 247 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 + +++DA +++ +A N +GD ++D LA G Sbjct: 248 MKSGD--------ELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGF 299 Query: 323 APGANIGDE-----CALFEATHGTAPKY------AGQDKVNPGSII--LSAEMMLRHMGW 369 +G + FEA+HGT + +NP ++ L M H Sbjct: 300 ITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAM--NHAAD 357 Query: 370 TE---------AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D L +F DA+ E + Sbjct: 358 VHNVDKERTLAFTAKMRAVIHQLFREGKGTRDLSGPS----GLTTEQFVDAVAERL 409 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 121/332 (36%), Gaps = 54/332 (16%) Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + + R A+ + V + ++ L +LDLY+ VR + G Sbjct: 97 TDDFYNSVLRNRSAV--HVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRF--- 151 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 ++ I +N+ +Y+ +E+ E I ++E Sbjct: 152 PDVNIRIIAQNNMGVYSDLEYSPVKGVVE-----------------------AISVSTQE 188 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G ++ +R A A+ +R VTL+HK T+GA ++ ++ Sbjct: 189 GNEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHC--------- 239 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++ + + + +++ P E+D I + I+ + GG + Sbjct: 240 ----------LELELMNVEDCIGRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFS 289 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 IGD A+F+ ++P I+ + + H+G+TE D + + M + Sbjct: 290 AVEIGDFHAVFKPLQ-VKLSLTNYPILSPYGIVNTIVDLFDHLGYTECGDALWEQMLRTM 348 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T DF D + + C+ II + Sbjct: 349 ESGIKTKDFGGE-DSGEYVICN-----IINRL 374 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 171 bits (434), Expect = 4e-41, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 122/337 (36%), Gaps = 55/337 (16%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRF---P 161 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDYCS---------- 248 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I ++ + D + +++ PA +D I + +++ + GG + Sbjct: 249 ---------IKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSA 299 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 +GD A+F+ T ++P I+ + +L H+G A + KGM + Sbjct: 300 IELGDSHAVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQESCAKSLWKGMLRTMT 358 Query: 386 AKTVTYDFERL-------MDGAKLLKCSEFGDAIIEN 415 T +F+ + L+CS G+ + + Sbjct: 359 DGIKTVEFDGPDTGEYVICNIMNKLRCSALGENVEKK 395 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 169 bits (427), Expect = 2e-40, Method: Composition-based stats. Identities = 52/129 (40%), Positives = 70/129 (54%), Gaps = 6/129 (4%) Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEATHGTAPKYAG 347 ++ P+++DV+ NL GD +SD A +GG+G+ P NIG + A+FE+ HGTAP AG Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAG 89 Query: 348 QDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 +D NP +++LSA MMLRHMG A I I K V D KCSE Sbjct: 90 KDMANPTALLLSAVMMLRHMGLHGHAKKIETACFDTIRDKKV-----LTKDLGGNPKCSE 144 Query: 408 FGDAIIENM 416 F I + Sbjct: 145 FTADICRRV 153 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 94/321 (29%), Gaps = 63/321 (19%) Query: 104 TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGI 163 P + LR+E+ Y +RP + + P+ G+ Sbjct: 36 GAPATSRPERGLLKLRKEMGTYGSMRPCFF---ASDSLVAPQG--------------RGV 78 Query: 164 EWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRD 223 A ++L + + + +P S +R A Sbjct: 79 PRHRLCHCARAHRRYL-----LWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDK 133 Query: 224 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIAD 283 + + N++ T ++ + +EF ++ ++ + + Sbjct: 134 KLWSLDNANVL-ATSRFWRKVMTETFEKEF-------------------PDLKVEHQLIN 173 Query: 284 AFLQQILLRPAEYD-VIACMNLNGDYISDALAAQVGGIGIAPGANIG-------DECALF 335 + + ++ P + V+ L GD ISDA IG+ P A++ ++ Sbjct: 174 SAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPDSIGLLPSASLSGIPDGNRKSNDIY 233 Query: 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFER 395 E H + + + S W +D + ++ V R Sbjct: 234 EPIH--VLPLVSRARASSTPSARSC-------PWPCFSDTL----STSLRRLWVPPWSLR 280 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 + E G+A+I + Sbjct: 281 TKELGGGANTKELGEAVINEV 301 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 157 bits (398), Expect = 5e-37, Method: Composition-based stats. Identities = 76/465 (16%), Positives = 131/465 (28%), Gaps = 123/465 (26%) Query: 25 ENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + P +E DG M +++ +K + G + Sbjct: 59 DRVRVQNPIVEMDG------DEMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDK 112 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRP-- 130 V + E+ + +Y VA+K TP + RS N +R L+ + P Sbjct: 113 VTV--ESAEATLKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPIL 170 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 K P + I R D Y + + K++ ++ Sbjct: 171 CXNVPRIVPGWKKP----ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNV 226 Query: 191 PE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247 + GI + + + + R +++ A A + + L K I+K +G Sbjct: 227 YDFKGPGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG-------- 277 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 + + D + L Y V AC N +GD Sbjct: 278 ----------------------------RYEHRLIDDMVAYALKSDGGY-VWACKNYDGD 308 Query: 308 YISDALAA---------------------------------QVG----GIGIAPGANIGD 330 SD LA G I I+ D Sbjct: 309 VQSDLLAQGFLLHMRNERSDYPVXLHLVKSYPILFVLSRIRFFGSYDFSIAISGKQLSSD 368 Query: 331 ECAL-FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHM-------GWTEAADLI 376 L EA HGT ++ Q + N + I + L H + + Sbjct: 369 GKTLEAEAAHGTVTRHFRQYQKGLETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVHKL 428 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKL-----LKCSEFGDAIIENM 416 + + +T D L+ G K L EF D + N+ Sbjct: 429 EAACIETVESGNMTKDLAILIHGPKASXEFYLNTEEFIDTVAHNL 473 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 154 bits (389), Expect = 6e-36, Method: Composition-based stats. Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 13/185 (7%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + + A +L P+ + G G+G +++ A+ + +AA + Sbjct: 8 YASSAIRATASPRSLSTSASTSPQ-FTVTLFPGHGVGPEISVAVQNIFNAA-------DV 59 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W E + + A+ LD +R R +KGP+ TP+G G RSLN+ LR+ Sbjct: 60 PIVWDEHHIDVD--NAKPGQDLISADALDSLRRNRFGLKGPMATPIGKGYRSLNLTLRKA 117 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RP G +P + D+V REN+E Y+G+E E + E Sbjct: 118 LGLYANVRPCVSIPGVQTPY---DDVDVVTVRENTEGEYSGLEHVVYPGVVESLKVITPE 174 Query: 182 EMGVK 186 + + Sbjct: 175 RVNAR 179 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 154 bits (388), Expect = 6e-36, Method: Composition-based stats. Identities = 63/407 (15%), Positives = 126/407 (30%), Gaps = 79/407 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + G+G G ++T +V+ + + + IY S + Sbjct: 3 SIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADAVT 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR-----SLNVALRQELDLYICLRPVRYYQGTPSP 140 ETL YR K ++ V R +R++L ++ T SP Sbjct: 63 EETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQA------IKVEHFTLSP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +++ R+ ++ Y+G S DA Sbjct: 117 TSS-----ILLVRDQAQGFYSGTNSVNTSKDAVSR----------------------TAH 149 Query: 201 CSEEGTKRLVRAAIEYAIAN--DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S+ R++ A+ A +SVT+V+K +G F W + Sbjct: 150 FSKAIFARILSYALGRANQLWGGTNSVTMVYK---FHLFDGLFHTWATE----------- 195 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 V + + +D++A + ++++ N D + L + G Sbjct: 196 -WERTFGVNIRFVQGDTMNRDLLAFGV--------SGHNLLISGNEYADIMQTILLDRFG 246 Query: 319 GIGIAPGANIGDEC--------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGW 369 +G A + + ++ HG+A G+ VNP + I +A +L G Sbjct: 247 -LGAQESACAENVYLHPDVQGLSEYQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQAGC 305 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D F +A ++ + Sbjct: 306 SGLKQRVDCVLGDLGARGIGTPDQ------GGTATTERFVEAFLQGL 346 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 154 bits (388), Expect = 8e-36, Method: Composition-based stats. Identities = 63/395 (15%), Positives = 114/395 (28%), Gaps = 47/395 (11%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I G G G ++ VV + + ++ S Sbjct: 5 DPLRIGVAIGHGTGPELATVFEHVVRELASR---YSLGVEFVRSDRIYHSYNSLPLADES 61 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE---LDLYICLRPVRYYQGTPSPV 141 T D+ E I R L V R LY +R + + Sbjct: 62 QNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYA-VR--QQLEAVKVEC 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + +++ R+ ++ Y G D+ + R+ + I F Sbjct: 119 FDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHFRKGVFQHIIAFSLERAREKWGY 178 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 G SV LV+K +G W +EFG ++ Sbjct: 179 DLGGI----------------KSVFLVYK---FHLFDGLLLSWARD-WTKEFGIKVEFIQ 218 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 P +N + +IA I+ I N + + + Sbjct: 219 PDTMNRN-LIAFGVHRCLMIAGNEYADIMQ------TIFLEKFNMRVQETSCSE---NVY 268 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + P N + ++ THG+A G+ VNP + I +A +L G I ++ Sbjct: 269 LKPVLN---RLSEYQTTHGSADDITGKGIVNPSATIRAAAAILERFG---GCVGIDAKVD 322 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +N + + D L + F D + + Sbjct: 323 DTLN--ILQKNKSGTPDQGGNLTTAAFVDVFLRTL 355 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 151 bits (381), Expect = 5e-35, Method: Composition-based stats. Identities = 65/404 (16%), Positives = 133/404 (32%), Gaps = 64/404 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI-----SWMEIYTGEKSTQVYG 79 + + G G G ++ +V+ K Y + ++ +T S + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLA-KQYSVNFEFVRSSSTYHSYHTLTVSGEDKN 62 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ET +Y+ + + + R+ A LY+ +R ++ Q Sbjct: 63 LITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHA----QSLYL-VR--QHLQAAKV 115 Query: 140 PVKHPELTD-MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + +++ R+ ++ YAG + + Sbjct: 116 EHFSLGDGNALLMVRDEAQGFYAGDNTYSADQLSITR----------------------T 153 Query: 199 KPCSEEGTKRLVRAAIEYAIAN-----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S+ R++R A++ A N VT+ +K +G F+ W Q + +F Sbjct: 154 TSFSKPVFDRIIRFALDRAAENWGPENVPKKVTMAYK---FHLFDGVFQAWEPQ-WKAQF 209 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 G + P + + + +I +++P +N G S Sbjct: 210 GIDFDFIQPD-TLNRSLMANGVQGRCIIIAGNEYADVIQP------VFLNWFGQ--STPE 260 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEA 372 + + P N + ++ HG+A A + VNP + I +A +L RH G Sbjct: 261 TMYAENVYLRPDVN---GLSEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGI 317 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L + ++ + K T D LK E D ++ + Sbjct: 318 QKLTEQAIQSLLQRKLTTPDQ------GGSLKTEETVDHFLQAI 355 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 149 bits (375), Expect = 2e-34, Method: Composition-based stats. Identities = 53/203 (26%), Positives = 90/203 (44%), Gaps = 33/203 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +++ +++K+ DAA + + G + G+ +P Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK-------VPVEFETENAGSDVYEKTGE--LIPES 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + Sbjct: 54 LYESVERNKIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNI 110 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+ IFREN+E IY G E + I +K +++G++ Sbjct: 111 DLAIFRENTEGIYIGEEKYENEEKT---------------------SAIAVKRITKKGSE 149 Query: 208 RLVRAAIEYAIANDRDSVTLVHK 230 L++ + + + L K Sbjct: 150 ELLKVLLNMQRIMEFRKLQLFIK 172 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 134 bits (337), Expect = 7e-30, Method: Composition-based stats. Identities = 66/409 (16%), Positives = 119/409 (29%), Gaps = 78/409 (19%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I G DG V A ++ + K I++ ++ ++ P Sbjct: 225 TVIAGYDG----VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANP---PERA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L P R L ++L Y PVR Sbjct: 278 L-------------WGVPDNTTGRK-LYKLVKQLKRYGI--PVRNAH------------- 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A + ++K + + + R + I + E Sbjct: 309 VSISRMSAGGGDQYGSFNM---PAQEDGILKVVVDGVEKHARRVSQGDPILLMSNDHEAI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V A ++ V K M++ + F + RE + Sbjct: 366 KDWVSQVFRDA-SSKHKEVYFGLKREYMEY-DEVFSTVINDVRRELAADHTSPPAFMIMR 423 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + L +++ P + NL+GD SD AA G + A Sbjct: 424 PSSQ---------------LIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSI 468 Query: 327 NIGDECAL-FEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHMG-------WT 370 + FEA HGTA + NP ++I + L +G Sbjct: 469 IESKSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALL 528 Query: 371 EAADLIVKGMEGAINAKTVTYDF---ERLMDGAKLLKCSEFGDAIIENM 416 + + + ++ + VT D + L+ F D+I + + Sbjct: 529 DYSARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRL 577 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 62/412 (15%), Positives = 120/412 (29%), Gaps = 84/412 (20%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + G DG V A ++ + + + + + ++ ++ P Sbjct: 225 TVVPGYDG----VMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNP---PQRA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L + + +K L Q+L Y G P + Sbjct: 278 LWGVPDNVSGMK--------------LYKLVQQLKHY----------GLP-----ERKAN 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A +IK + + + I E Sbjct: 309 VSISRMSAGGGDQYGSYNTPAPEDG---IIKVIMDGEEKHARTVKSNDPILFMSNDRESI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V+ A + + + L RE + + L++ Sbjct: 366 KDWVKQVFRDAALYKK--------------------EVYFGLKREFVNYDEVYSSIILEI 405 Query: 267 KNPNTGKEIVIKDVIADAFLQQ---ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + + + +Q ++ P + + NL+GD SD AA G + A Sbjct: 406 RKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATA 465 Query: 324 PGANIGDECA-LFEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHM------- 367 + LFEA HGTA + N ++I + L + Sbjct: 466 SSVIKSKDGTLLFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNA 525 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERL---MDGAKLLKCSEFGDAIIENM 416 E A+ + + + T+T D + + ++ F DAI N+ Sbjct: 526 PLAEYAEALKAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESNL 577 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 118 bits (296), Expect = 3e-25, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 78/225 (34%), Gaps = 30/225 (13%) Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E + S++G + +R A + A R VTL++K ++G+ + +L Sbjct: 13 EGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCH 72 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 ++ + +++ P +D + ++S Sbjct: 73 YKDCLELELMEVE-------------------EAISRLMTEPTYFDCLFASERYATFLSA 113 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG + IGD A+F+ T ++ I+ + + +H+G + Sbjct: 114 ICSGVCGGANLFSAVEIGDHHAVFKPLQ-TKLSLTNYANLSAYGIVSTIVDLFQHLGHDK 172 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + ++ +N T + + G+ +I N+ Sbjct: 173 CADALWCELKRTMNEGIRTK------EFGG----QDTGEYVICNI 207 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 117 bits (294), Expect = 6e-25, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 51/138 (36%), Gaps = 11/138 (7%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 20 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 76 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 77 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 134 Query: 118 LRQELDLYICLRPVRYYQ 135 LR L ++ LRP Sbjct: 135 LRSGLKVFANLRPASVLP 152 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 116 bits (290), Expect = 2e-24, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 8/122 (6%) Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSII 357 N+ GD +SD A G I +AP +I E +LFE HG+ P G+ NP + Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 358 L---SAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 M+L H+G+ E I +E +++ D K + G AI Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPL--TPDLGGSAKTDDLGKAIAA 118 Query: 415 NM 416 + Sbjct: 119 AI 120 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 76/210 (36%), Gaps = 23/210 (10%) Query: 112 RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169 RS N +R L+ + P + S K P + I R D Y + + Sbjct: 32 RSPNGTIRNILNGTVFREPILCKNVPRILSGWKKP----ICIGRHAFGDQYRATDTIING 87 Query: 170 ADAEKVIKFLR-EEMGVKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTL 227 K++ E + + G+ + + + + R +++ A++ + + L Sbjct: 88 PGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLYL 146 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 K I+K +G FKD ++ E++ + + W + + D + Sbjct: 147 STKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIW-------------YEHRLIDDMVA 193 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQV 317 + Y V AC N +GD SD LA Sbjct: 194 YAVKSEGGY-VWACKNYDGDVQSDFLAQIF 222 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 29/139 (20%), Positives = 49/139 (35%), Gaps = 17/139 (12%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + ++ + + ++ ST Sbjct: 45 AKYGGRHTVTLIPGDGIGPELLNHVRELFR-------FSCVPVDFEVVHVNSSSTSEDDI 97 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTP 138 + IR VA+KG + T +S N LR LDLY + + G Sbjct: 98 S-----NAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQ 152 Query: 139 SPVKHPELTDMVIFRENSE 157 + + D++I E SE Sbjct: 153 T---RHKNIDIIIILEKSE 168 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 103 bits (256), Expect = 1e-20, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 26/129 (20%) Query: 117 ALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI 176 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 1 MLHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE--- 54 Query: 177 KFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 236 +K ++ + R+ A + A V VHK NI K Sbjct: 55 --------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKL 94 Query: 237 TEGAFKDWG 245 +G F Sbjct: 95 GDGPFLQCC 103 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 101 bits (252), Expect = 5e-20, Method: Composition-based stats. Identities = 59/409 (14%), Positives = 118/409 (28%), Gaps = 81/409 (19%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ---VYGQDVW 83 P + G G G +V +V+ + + + +Y S + Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAG 90 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSP 140 +P + + A V R ++ LY+ +R + + Sbjct: 91 VPE--IRRLSAEDAA--HYEEWLRARARAGTRVVFRTAINAQSLYL-VR--QRLRAVKVD 143 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + +++ R+ ++ Y G + Sbjct: 144 TLDADGARLLLVRDEAQGFYTGGNTHTPGHVSR------------------------TTE 179 Query: 201 CSEEGTKRLVRAAIEYAIAN---DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S E T++L+ A+ A + + +K +GA W A E Sbjct: 180 FSREITEQLLAYALRRAREEWPEGPARIVMAYK---FHLLDGALDAWVRDFAARENIEVG 236 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP-AEYDVIACMNLNGDYISDALAAQ 316 + D + ++ P + V+ N D + L + Sbjct: 237 VFQP---------------------DTVNRNLVAHPPEDRTVLLAGNEWADIMHLVLLDR 275 Query: 317 VGGIGIAP---GANIGDECAL-----FEATHGTAPKYAGQDKVNPGSIILSAEMML-RHM 367 G G N+ + A+ ++ HG+A G+D +NP + + +A + R++ Sbjct: 276 YGS-GRQEDHCTRNVHLDPAVAELVEYQTVHGSADDLEGRDLLNPVATLRAAAAIAERYV 334 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G T A + A T D + DA IE + Sbjct: 335 GCTGAEAATEAALARLAAAGVRTPDQ------GGKHSTTGVVDAFIEEL 377 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 96.0 bits (237), Expect = 2e-18, Method: Composition-based stats. Identities = 42/316 (13%), Positives = 95/316 (30%), Gaps = 59/316 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + ++GD V L ++ + + E+ G + + LP Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKS----SVNDSTAFEVTELPFGVNGVLSFNEP--LPN 55 Query: 87 ETLDLIREYRVAIKGP----LTTPVGGGIRSLNVALRQELDLYICLRPVR----YYQGTP 138 +TL ++ Y + G + T ++ VALR+ L++ + + V+ +P Sbjct: 56 QTLRELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASP 115 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + TD +I R V + Sbjct: 116 LKNQIVRDTDFIIV-----------------------QSAKRANDHVDGNISVDDFAQDT 152 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 + ++++ A E A+ R VT+V + +T + ++A+ Sbjct: 153 ITYEQREVEQVITAGFERAMNRKRA-VTVVTPFDSF-YTSKIWALTAEKIAKIY------ 204 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 ++V+ V + I+ +P DV+ +++ G Sbjct: 205 --------------PDVVVNYVSLSCVISTIIQQPTSLDVVVAPKWVDQVLNEESQKITG 250 Query: 319 GIGIAPGANIGDECAL 334 P + + + Sbjct: 251 LPETVPVSMKNNSGQM 266 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 91.7 bits (226), Expect = 4e-17, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 53/153 (34%), Gaps = 12/153 (7%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + E + + GD IG ++ LK + VE+ + ++ + S + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRY--GLLAGASLDKTNEP- 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQG 136 + + LD + G + P + LRQ LD + +RP R + Sbjct: 58 -ITDKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCR-FCA 115 Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169 + + P +DMV N + YA Sbjct: 116 SSLVEQSPLKSDMVNG-VNFGEQYAARSRSTGG 147 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 91.0 bits (224), Expect = 8e-17, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 46/136 (33%), Gaps = 6/136 (4%) Query: 283 DAFLQQILLRPAEYDV--IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHG 340 DA + + + + + A+ + A ++ + HG Sbjct: 153 DANVLSFIKHSQYSKANQVVSSMEGANVLKALYASIYKSLNRAHTLIEVEDGYITMPMHG 212 Query: 341 TAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 AP G NP +++++ +L G+ E A + +E A + D Sbjct: 213 HAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVENQIESAFYENR----DQTTPDQG 268 Query: 401 KLLKCSEFGDAIIENM 416 +L ++ ++E + Sbjct: 269 GVLNTEKYMAMMVECI 284 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 89.8 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 56/333 (16%), Positives = 113/333 (33%), Gaps = 54/333 (16%) Query: 48 VVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV 107 V+ AA+E +W ++ G R+ + P P Sbjct: 22 VLPAALELLESAGLTANW--RIVAGQAPDGDGG------------RKPEAGLLPPFAEP- 66 Query: 108 GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167 G L A R+ + + V+ ++++FR + G+E+++ Sbjct: 67 GASAYGLARAARRAWGGTFSV-----IERRGPLVRSDGTVNVLLFRYELDMSDTGMEFES 121 Query: 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTL 227 +S + ++K E + PE +GI+ + + VR A+ D D + + Sbjct: 122 NSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVV 178 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 HKGN +K T+G F + +++ I + +I D Sbjct: 179 AHKGNSIKHTDGLFALTAAE-----------------TLESLAGAAGIAWRSLIIDHMAA 221 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQVGG--IGIAPGANIGDECALFEATHGTAPKY 345 +++ P +Y I + D ++ ALA Q+ +G+ + H A Sbjct: 222 ELVRNPLDYRAILTHSSFADLLAAALAGQMTTDQLGVCTTYDPAGRPLF---GHDPALDT 278 Query: 346 AGQDKVNP--------GSIILSAEMMLRHMGWT 370 + D +P S + + + H+ Sbjct: 279 SAPD-ADPERWRVRRLASTLAAGAALAEHLRLP 310 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 89.8 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 41/79 (51%), Gaps = 5/79 (6%) Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLM 397 HG+APKYAG KVNP +++LS MML+ + EAA I KG++ + Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKH-----LTY 58 Query: 398 DGAKLLKCSEFGDAIIENM 416 D E+ DAII+ M Sbjct: 59 DAGGTASTDEYADAIIKAM 77 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 84.0 bits (206), Expect = 9e-15, Method: Composition-based stats. Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Query: 335 FEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 +E G+AP AG++ NP + ILS M++R+ M +D I + + T D Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 394 ERLMDGAKLLKCSEFGDAI 412 D K ++ GD I Sbjct: 71 AN--DKEKCESTNDIGDII 87 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 80.2 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 40/117 (34%), Gaps = 15/117 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ KV+D K + I G S G V L E Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTK---YGHSFLYEAILMGGCSIDATG--VPLTDE 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR----------SLNVALRQELDLYICLRPVRYY 134 + + + G + + + LR+ L+L+ LRP Y Sbjct: 59 AIAAAKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 80.2 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 5/103 (4%) Query: 16 LQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 ++ + I + GDG+G +V P + V+ A S+ E+ G + Sbjct: 30 IRCAANTPKKRYTIAVLPGDGVGNEVIPVAVDVLCLAG---SLEGIDFSFEELPIGGVAL 86 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 + G V LP ETL ++ + G + I +++ Sbjct: 87 DLVG--VPLPKETLIRAKQSDALLLGAVGWYGIITITFVHLKF 127 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 78.2 bits (191), Expect = 6e-13, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 30/72 (41%) Query: 345 YAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK 404 + NP ++ +A ML ++G A LI + T D + + + Sbjct: 2 ICRXNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVG 61 Query: 405 CSEFGDAIIENM 416 EF +A+I+N+ Sbjct: 62 TKEFAEAVIDNL 73 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 77.9 bits (190), Expect = 6e-13, Method: Composition-based stats. Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%) Query: 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMD 398 G+AP AG++ NP + ILS M++R+ M + AD I + A+ T D + + Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVNE 61 Query: 399 GAKLLKCSEFGDAIIENM 416 + S+ GD I + Sbjct: 62 --THISTSDMGDVISNIL 77 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 76.7 bits (187), Expect = 2e-12, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 NP ++++ A MLRH+ ++ I + + A V R D EF Sbjct: 155 IANPTAMLMCASKMLRHVNLQHYSESIRNAIREVLAAGKV-----RTRDLGGSSSTHEFT 209 Query: 410 DAIIENM 416 DA+I+ + Sbjct: 210 DAVIKAI 216 Score = 71.3 bits (173), Expect = 6e-11, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 45/131 (34%), Gaps = 18/131 (13%) Query: 4 KVVVPAQGKKITLQNGKLNVPE----NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKG 59 + P + + + I GDG+ ++ ++ V+ A Sbjct: 38 SIKSPIARAFASGEQNEDKFSNLPVERITCTLIPGDGVYPELMNSVQTVLKAIGAPIDFE 97 Query: 60 ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV---GGGIRSLNV 116 S ++ + K + + I R+ + G L +P G +++L++ Sbjct: 98 TILFSEVQHSSSAKV-----------EDVIKSINRNRICLMGALMSPDVSYSGELQNLHM 146 Query: 117 ALRQELDLYIC 127 LR+ LDL Sbjct: 147 KLRKGLDLIAN 157 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 75.2 bits (183), Expect = 5e-12, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GD IG +V ++ V+ + E ++ + E+ G + G+ ++ Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQE--ILSTYRLEFTELDWGTARYKRTGK--YM 62 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQEL 122 PA+ L ++ + I G + P IR L+ +R+ Sbjct: 63 PADGLSTLKTFHAGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 71.7 bits (174), Expect = 5e-11, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 35/107 (32%), Gaps = 13/107 (12%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG+++T +KV+ A K +R S G + Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSAFSLK----KRTFDLRSELIDGCSIDTDGTP--IT 415 Query: 86 AETLDLIREYRVAIKGPLTTPVGG-------GIRSLNVALRQELDLY 125 + + + + P G + LR+ ++ + Sbjct: 416 KTVIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 70.9 bits (172), Expect = 8e-11, Method: Composition-based stats. Identities = 29/212 (13%), Positives = 58/212 (27%), Gaps = 46/212 (21%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + G I + + I G+ Sbjct: 56 KSKYGGINTVSLVTGTTI------IGQQGAQFVSSLLSSSRVPVEVQVIEAGQD------ 103 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 E + R A+ + + + + +LDLY+ R + G Sbjct: 104 ------DEYFHSVLRNRTAV--HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKC 155 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+ + +N+ I+ +E+ E + Sbjct: 156 RF---PGVDIQLIGQNNMGIFNELEYSPVEGVVE-----------------------ALS 189 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 231 S++G + +R A + A R VTL+ +G Sbjct: 190 VVSQKGNDKYLRYAFKAAAKAGRKRVTLIKQG 221 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 67.1 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 9/81 (11%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ ++ K+ +AA I W + + +P++ Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAANA-------PIEWDPVDV--TPVKGDDGIFRIPSK 77 Query: 88 TLDLIREYRVAIKGPLTTPVG 108 ++L+R ++ +KGPL TP Sbjct: 78 CIELMRINKIGLKGPLATPNW 98 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 66.3 bits (160), Expect = 2e-09, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 33/88 (37%), Gaps = 11/88 (12%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 + I GDGIG ++T ++ ++ + I W + S Sbjct: 1 QPTKYGGVYTVTLIPGDGIGNEITDSVKEIFEYVNA-------PIEWEQYNVSGMS---- 49 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTP 106 L + ++ +R RV +KG L TP Sbjct: 50 SAGEDLFKQAVESLRRNRVGLKGILFTP 77 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 62.4 bits (150), Expect = 3e-08, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 334 LFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADL 375 +FE HG+AP AG++ NP + I S ML RH G A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 61.7 bits (148), Expect = 4e-08, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 32/87 (36%), Gaps = 6/87 (6%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY-TGEKSTQVYGQDVWL 84 + I I GDGIG + P L+V DAA + + + +G+ Sbjct: 3 SYRIAVIPGDGIGKEAVPERLRVPDAAARR---FGFALHCGHFDFASSDTRARHGK--LR 57 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI 111 P + D +R Y G + P G Sbjct: 58 PDDRFDTLRGYDALFFGAVGRPDTGAA 84 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.3 bits (147), Expect = 6e-08, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 34/105 (32%), Gaps = 29/105 (27%) Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + +G+ +GD LF + ++ NP + +L++ MML H+ Sbjct: 25 VGPELMAAVGVIECLKLGD--GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHL---- 78 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D C +F +A+I + Sbjct: 79 -----------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 58.6 bits (140), Expect = 4e-07, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 32/89 (35%), Gaps = 6/89 (6%) Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G LFE + ++KVNP +I S ++L G E A I + A Sbjct: 1 MGIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFGLQEEAGAIQMAVNSAGERG 58 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D C + GD + + Sbjct: 59 MYTTLDTLPKDI----NCDQLGDYLAAAI 83 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 57.8 bits (138), Expect = 8e-07, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 53/152 (34%), Gaps = 29/152 (19%) Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 + HKGN +K+T+G F Q + G I+ + +I D Sbjct: 1 MTHKGNSIKYTDGLFAVVAKQELEKLIGDS-----------------GIIQESLIIDHMA 43 Query: 287 QQILLRPAEYDVIACMN---------LNGDYISDALAAQVGGIGIAPGANIGDECALFEA 337 ++ P +Y I L+G +D IG A G + AL A Sbjct: 44 AELTRNPQDYRAILTHGAFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDPA 102 Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 H AP+ ++ +L+ ++ H+ Sbjct: 103 RHTRAPEAEAAGRLRSV--LLAGSLLADHLDQ 132 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 56.7 bits (135), Expect = 2e-06, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 27/61 (44%), Gaps = 5/61 (8%) Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 ++L++ +ML H+ + A++I + +N + +D SE +I+ Sbjct: 1 MLLASCLMLDHLKLHDYANMIRSAILTTMNETRL-----HTVDIGGQGTTSEVVQSIMRI 55 Query: 416 M 416 + Sbjct: 56 I 56 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 55.1 bits (131), Expect = 4e-06, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 23/54 (42%), Gaps = 3/54 (5%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I + GDGIG ++ +KV++ A EK + G + +G Sbjct: 9 SKQILILPGDGIGPEIMTEAVKVLELANEK---YQLGFELTHDVIGGAAIDKHG 59 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 54.4 bits (129), Expect = 9e-06, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 25/52 (48%) Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MGW EA LI +E A + T D R M + L EFG+ I+ + Sbjct: 1 EYMGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYIMSVL 52 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 53.6 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 7/71 (9%) Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 G I++ + GDGIG ++ ++ +V AA + I W E + Sbjct: 28 GPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAA-------DVVIDWDEQFV 80 Query: 71 GEKSTQVYGQD 81 G + Sbjct: 81 GTEVDPRTNSS 91 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 52.0 bits (123), Expect = 3e-05, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 5/76 (6%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I GDGIG +++ A++K+ DAA R +E G K ++Y V Sbjct: 1 AGGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIE---GYKFNEMYLDTV 57 Query: 83 WLPAET--LDLIREYR 96 L ET I+ Sbjct: 58 CLNIETACFATIKCSD 73 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 52.0 bits (123), Expect = 4e-05, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 23/57 (40%) Query: 220 NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIV 276 + VT +HK NIMK +G F +LA++ E + P+ I Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLERRGSESGIDTDKPDVCFNIH 131 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 50.1 bits (118), Expect = 1e-04, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 29/84 (34%), Gaps = 14/84 (16%) Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 ++E A++ A + + L K I+K +G FKD ++ + + + G Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 262 PWLKVKNPNTGKEIVIKDVIADAF 285 W + + D Sbjct: 60 IW-------------YEHRLIDDM 70 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 48.6 bits (114), Expect = 5e-04, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 17/51 (33%), Gaps = 5/51 (9%) Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G E A+ I +E +N D R EF A + Sbjct: 39 HVGEGEKANAIRNAVEKVLN-----IDNVRTGGLGGSATTKEFTAATERRL 84 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 46.7 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 11/32 (34%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDA 51 + I GDGIG ++ + V Sbjct: 106 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 45.1 bits (105), Expect = 0.004, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 26/79 (32%), Gaps = 13/79 (16%) Query: 351 VNPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL 403 NP + I + L T+ A+ + + I A +T D + G Sbjct: 5 TNPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSA 64 Query: 404 ------KCSEFGDAIIENM 416 EF + + EN+ Sbjct: 65 QCSDYLNTFEFMEKLGENL 83 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 44.3 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 18/32 (56%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKG 59 I + GDGIG ++ A L+V++A EK Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEKQVLT 35 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 44.3 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 18/50 (36%), Gaps = 3/50 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 I + GDGIG ++ L+V++A EK G Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEK---TGFDYEIDRRPFGGADIDA 50 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 44.0 bits (102), Expect = 0.012, Method: Composition-based stats. Identities = 10/82 (12%), Positives = 24/82 (29%), Gaps = 13/82 (15%) Query: 348 QDKVNPGSIILSAEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 + NP + I + L A + + ++ A ++ D + G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 401 KLLKCSEF------GDAIIENM 416 + ++ D E + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERL 84 >UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyaloperonospora parasitica RepID=Q6UB50_9STRA Length = 55 Score = 42.4 bits (98), Expect = 0.032, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 18/50 (36%), Gaps = 2/50 (4%) Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A LI K +E + T D D + ++ G AII M Sbjct: 3 FQMETEAQLIEKAVEQVLLDGMRTGDL--TKDKSAVVGTKTMGAAIIAKM 50 >UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q0V0_9BACT Length = 346 Score = 42.4 bits (98), Expect = 0.033, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 39/121 (32%), Gaps = 14/121 (11%) Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIK-DVIADAFLQQILLRPAEYDVIACMNLNGD 307 A EE + + + V AD + L +YD++ Sbjct: 227 AGEEGIFGNEEKNIIVPAVKKAKKLGVECNGPVSADTVFYKALK--GQYDLVVS------ 278 Query: 308 YISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDKVNPGSI---ILSAEM 362 D A + G NI HGTA AG+ NP S+ I++A M Sbjct: 279 MYHDQGAIPLKLHAFETGVNITLGIPFIRTSPDHGTAYDIAGKGIANPDSMKEAIMTAIM 338 Query: 363 M 363 M Sbjct: 339 M 339 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.310 0.129 0.332 Lambda K H 0.267 0.0393 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,353,794,029 Number of Sequences: 3077464 Number of extensions: 46845164 Number of successful extensions: 155561 Number of sequences better than 1.0e-01: 235 Number of HSP's better than 0.1 without gapping: 442 Number of HSP's successfully gapped in prelim test: 29 Number of HSP's that attempted gapping in prelim test: 152595 Number of HSP's gapped (non-prelim): 513 length of query: 416 length of database: 1,040,396,356 effective HSP length: 131 effective length of query: 285 effective length of database: 637,248,572 effective search space: 181615843020 effective search space used: 181615843020 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 94 (40.9 bits)