BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (416 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 693 0.0 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 652 0.0 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 611 e-173 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 527 e-148 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 466 e-130 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 449 e-124 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 442 e-123 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 436 e-121 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 432 e-119 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 422 e-117 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 387 e-106 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 363 6e-99 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 357 7e-97 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 332 1e-89 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 272 2e-71 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 215 3e-54 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 210 9e-53 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 205 3e-51 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 201 5e-50 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 197 4e-49 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 194 4e-48 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 191 5e-47 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 181 5e-44 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 180 7e-44 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 180 1e-43 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 178 3e-43 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 177 9e-43 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 176 2e-42 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 174 5e-42 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 172 3e-41 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 170 9e-41 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 168 3e-40 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 168 4e-40 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 166 2e-39 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 165 4e-39 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 164 5e-39 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 162 2e-38 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 158 3e-37 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 157 5e-37 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 156 1e-36 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 155 2e-36 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 154 6e-36 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 152 2e-35 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 152 2e-35 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 151 4e-35 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 150 1e-34 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 149 1e-34 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 148 4e-34 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 148 5e-34 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 146 2e-33 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 145 2e-33 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 143 1e-32 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 142 2e-32 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 137 7e-31 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 135 3e-30 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 134 5e-30 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 134 8e-30 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 131 4e-29 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 130 1e-28 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 130 1e-28 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 128 4e-28 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 128 5e-28 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 127 9e-28 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 127 1e-27 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 126 1e-27 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 124 5e-27 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 124 6e-27 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 124 6e-27 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 123 2e-26 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 123 2e-26 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 122 2e-26 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 121 6e-26 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 120 9e-26 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 119 2e-25 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 119 2e-25 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 118 4e-25 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 118 5e-25 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 117 6e-25 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 117 1e-24 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 116 1e-24 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 116 1e-24 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 116 2e-24 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 116 2e-24 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 115 2e-24 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 115 3e-24 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 114 5e-24 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 114 5e-24 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 114 7e-24 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 114 9e-24 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 114 9e-24 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 113 1e-23 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 113 2e-23 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 113 2e-23 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 112 2e-23 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 112 4e-23 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 110 9e-23 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 110 1e-22 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 110 1e-22 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 109 2e-22 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 109 2e-22 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 109 2e-22 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 108 3e-22 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 108 4e-22 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 108 5e-22 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 107 1e-21 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 106 1e-21 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 106 2e-21 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 106 2e-21 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 105 2e-21 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 105 2e-21 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 105 2e-21 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 104 6e-21 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 103 1e-20 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 103 1e-20 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 103 2e-20 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 102 3e-20 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 97 8e-19 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 97 1e-18 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 97 2e-18 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 96 2e-18 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 96 2e-18 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 96 3e-18 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 95 5e-18 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 94 8e-18 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 94 1e-17 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 94 1e-17 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 93 2e-17 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 92 3e-17 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 92 3e-17 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 92 4e-17 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 92 4e-17 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 92 5e-17 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 91 7e-17 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 91 8e-17 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 91 1e-16 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 90 2e-16 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 89 2e-16 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 89 4e-16 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 85 5e-15 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 84 1e-14 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 84 1e-14 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 82 3e-14 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 81 8e-14 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 80 1e-13 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 79 5e-13 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 78 7e-13 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 77 1e-12 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 76 2e-12 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 75 6e-12 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 74 7e-12 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 74 1e-11 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 72 4e-11 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 71 8e-11 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 70 1e-10 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 70 2e-10 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 69 4e-10 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 68 5e-10 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 68 7e-10 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 67 2e-09 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 66 2e-09 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 64 1e-08 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 62 3e-08 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 61 9e-08 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 59 4e-07 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 57 1e-06 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 54 1e-05 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 54 1e-05 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 52 3e-05 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 51 9e-05 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 50 1e-04 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 49 5e-04 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 47 0.002 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 45 0.004 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 44 0.014 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 42 0.031 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 42 0.050 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 41 0.093 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 41 0.099 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 693 bits (1789), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/414 (78%), Positives = 370/414 (89%), Gaps = 1/414 (0%) Query: 4 KVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 K+ VPA G KIT+ + L+VP+NPIIP+IEGDGIGVD++P M+KVVDAAVEKAYKGERK Sbjct: 5 KIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERK 64 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I+WME+Y GEK+TQVY QD WLP ETLD +R+Y V+IKGPLTTPVGGGIRSLNVALRQ+L Sbjct: 65 IAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQQL 124 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY+C RPVR+++G PSPVK P DMVIFRENSEDIYAG+EWKA S +AEKVIKFL EE Sbjct: 125 DLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEE 184 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 MGVKKIRF E+CGIGIKP S+EGTKRLVR A++YA+ NDR SVTLVHKGNIMKFTEGAFK Sbjct: 185 MGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFK 244 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 DWGY++AR+EFG EL+DGGPW++ KNP TGK +V+KDVIADA LQQILLRPAEYDVIA + Sbjct: 245 DWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATL 304 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362 NLNGDY+SDALAA+VGGIGIAPGAN+ D A+FEATHGTAPKYAGQDKVNPGS+ILSAEM Sbjct: 305 NLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSAEM 364 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MLRHMGWTEAADLI+KG GAI AKTVTYDFERLMDGA LL CSEFGDA+I M Sbjct: 365 MLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 652 bits (1681), Expect = 0.0, Method: Compositional matrix adjust. Identities = 307/416 (73%), Positives = 360/416 (86%), Gaps = 1/416 (0%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+ Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAAQVGGIGIAPGAN+GDE A+FEATHGTAPKYAG++KVNPGS+ILSA Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 611 bits (1575), Expect = e-173, Method: Compositional matrix adjust. Identities = 291/416 (69%), Positives = 347/416 (83%), Gaps = 8/416 (1%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E Sbjct: 11 PKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70 Query: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 ++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ Sbjct: 71 VFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 ++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+ Sbjct: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA Sbjct: 190 NELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY VIA Sbjct: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIA 309 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA Sbjct: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM Sbjct: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 527 bits (1357), Expect = e-148, Method: Compositional matrix adjust. Identities = 265/421 (62%), Positives = 315/421 (74%), Gaps = 17/421 (4%) Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 +KIT LNVP PIIP+I GDGIG D+ A +V+DAAVEKAY GE++I W E+ Sbjct: 3 AEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLA 62 Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130 G+K+ G+ WLP ETLD I+EY +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLRP Sbjct: 63 GQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP 120 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 VR+++G PSPVK P+ DMVIFREN+EDIYAGIE+K + + +KVI FL+ EMG IRF Sbjct: 121 VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF 180 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 PE GIGIKP S+EGT+RLVRAAI+YAI N+R SVTLVHKGNIMKFTEG+FK WGY LA Sbjct: 181 PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL 240 Query: 251 EEFGGELI-----------DGGPWLKVKNPNTGKE--IVIKDVIADAFLQQILLRPAEYD 297 EFG ++ +G V KE I+IKD IAD FLQQIL RPAE+D Sbjct: 241 TEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD 300 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC--ALFEATHGTAPKYAGQDKVNPGS 355 V+A MNLNGDYISDALAAQVGGIGIAPGANI E A+FEATHGTAPKYAG +KVNP S Sbjct: 301 VVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSS 360 Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ILS+ +ML H+GW EAAD I +E I +K VTYDF RLMDGA+ + S F D +I+N Sbjct: 361 VILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKN 420 Query: 416 M 416 + Sbjct: 421 L 421 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 466 bits (1200), Expect = e-130, Method: Compositional matrix adjust. Identities = 243/474 (51%), Positives = 311/474 (65%), Gaps = 60/474 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G+KIT QNG+ VP+NPI+P+I GDG G+D+ PA KV+DAAV KAY G+ Sbjct: 1 MYEKITPPSTGEKITFQNGEPIVPDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGK 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISW ++Y G+++ +YG +LP +TL I+EY +AIKGPLTTP+GGGIRSLNVALRQ Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K P+ D++++REN+EDIY GIEWK S E++I L Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILN 180 Query: 181 E-------EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA--IANDRDSVTLVHKG 231 + E G K+I P GIGIKP S G++RLVR A+++A + ++ VTLVHKG Sbjct: 181 KDLIPATPEHGKKQI--PLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKG 238 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELI-DGGPWL---KVKNPNTGKE------------- 274 NIMK+TEGAF+DWGY+LA +EF E + + W+ K KNP E Sbjct: 239 NIMKYTEGAFRDWGYELATQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNL 298 Query: 275 -------------------------------IVIKDVIADAFLQQILLRPAEYDVIACMN 303 +++ D IAD+ QQI RP EY ++A MN Sbjct: 299 TPEKKAQIVKEVETVINSIWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMN 358 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363 LNGDY+SDA AA VGG+G+ PGANIGD CA+FEATHGTAPK+AG DK+NPGS+ILS MM Sbjct: 359 LNGDYLSDAAAAIVGGLGMGPGANIGDSCAIFEATHGTAPKHAGLDKINPGSVILSGVMM 418 Query: 364 LRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMD-GAKLLKCSEFGDAIIENM 416 L +MGW EAADLI +G+ +I VTYD RLM+ + LKCSEF D II+ Sbjct: 419 LEYMGWQEAADLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQF 472 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 449 bits (1155), Expect = e-124, Method: Compositional matrix adjust. Identities = 209/412 (50%), Positives = 298/412 (72%), Gaps = 5/412 (1%) Query: 7 VPAQGKKITL-QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 VP QG+ I + +NG+ +P PII YI+GDG+G DV P M KVVD+A+ Y+ +RKI W Sbjct: 11 VPEQGQSIKIAKNGQWQIPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHW 70 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLY 125 M++Y GE++ ++Y D W P ET++ +RE ++AIKGPLTTP+GGG RSLNVALRQE+DL+ Sbjct: 71 MQVYNGEQAAKLYDGD-WFPQETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQEMDLF 129 Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 + +R ++ + PSP+K+P LT++ + R++SED+Y+GIEW+A S ++EKV+ FL EEMGV Sbjct: 130 VNMRTIKGFSALPSPLKNPYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGV 189 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 ++RF + CGIGIK S+EG++RLVR AI YA+ N+ +S+TLVHKGN++KFT+GAFK WG Sbjct: 190 TRLRFTQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWG 249 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGK-EIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 + LA+ E+ + G WL + P G+ ++IK+VIAD LQQ L+ P ++DV+A N Sbjct: 250 FALAKREYQAIDDENGRWLHI--PRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQ 307 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 NGD+++D L+AQVGG+GI P AN+ +E A FE THGT + AGQ+K NP S ILSA +ML Sbjct: 308 NGDFLADMLSAQVGGVGIMPAANLNNEVAFFEPTHGTFARIAGQNKANPSSSILSAVLML 367 Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + M W EAA+LI +E + A VT+D + L C++F +IE+ Sbjct: 368 KFMQWHEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEHF 419 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 442 bits (1138), Expect = e-123, Method: Compositional matrix adjust. Identities = 239/475 (50%), Positives = 300/475 (63%), Gaps = 61/475 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180 Query: 181 EE-------MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA--IANDRDSVTLVHKG 231 +E +G K+IR GIGIKP S+ G++RLVR AI +A + + VTLVHKG Sbjct: 181 DELIPTTPALGKKQIRL--DSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKG 238 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGE--------------------------LIDGGP--- 262 NIMKFTEG F+DWGY+LA EF E +ID G Sbjct: 239 NIMKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTL 298 Query: 263 -------------------WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 W N +++++ D IAD+ QQI RP EY ++A MN Sbjct: 299 TEEKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMN 358 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363 LNGDY+SDA AA VGG+G+ PGANIGD A+FEATHGTAPK+AG D++NPGS+ILS MM Sbjct: 359 LNGDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMM 418 Query: 364 LRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIENM 416 L MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ + Sbjct: 419 LEFMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSHF 473 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 436 bits (1121), Expect = e-121, Method: Compositional matrix adjust. Identities = 221/421 (52%), Positives = 292/421 (69%), Gaps = 10/421 (2%) Query: 3 SKVVVPAQGKKITLQNG---KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKG 59 K+ VP G+KITL+ G ++ VP+NPIIP I GDGIG DV PA KV++AA E Sbjct: 4 DKIEVPDAGEKITLKEGSEDEIEVPDNPIIPIIHGDGIGKDVGPAAQKVLEAAAEATG-- 61 Query: 60 ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR 119 R ISWM +Y GE + + YG+DV LP ET+D IRE+RVAIKGPLTTPVG G RSLNVALR Sbjct: 62 -RDISWMRVYAGESAREEYGEDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVALR 120 Query: 120 QELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFL 179 Q LDLY +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F+ Sbjct: 121 QTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFV 180 Query: 180 REEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG 239 +EMG + GIG+KP +E+G+KRLVR AI+YA+ +DRD VTLVHKGNIMKFTEG Sbjct: 181 EDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEG 240 Query: 240 AFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPAE 295 F DWG ++A EE+ + + P W + ++ +++++ +ADA LQ + LR E Sbjct: 241 QFGDWGMEVADEEYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDE 300 Query: 296 YDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGS 355 +D++A NLNGDY+SDA AQ+GG+GIAPG N G L E HG+APK AGQD NP + Sbjct: 301 FDILAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGKGRMLAEPVHGSAPKRAGQDMANPTA 360 Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ILS +M ++GW +AADLI +E I++ VTYD ER ++ A+ L SE+ D I++ Sbjct: 361 MILSGRLMFDYLGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDT 420 Query: 416 M 416 + Sbjct: 421 I 421 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 432 bits (1110), Expect = e-119, Method: Compositional matrix adjust. Identities = 216/418 (51%), Positives = 290/418 (69%), Gaps = 19/418 (4%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 +K+T+ NG+L VP NP IP+IEGDGIG ++ A V DAAV+KAY G+++++W+ + G Sbjct: 4 EKVTMNNGQLQVPNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAG 63 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131 E + + GQ WLP +TL +REY V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV Sbjct: 64 ETAYKKTGQ--WLPDKTLATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPV 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 YY GTPSPV HPE ++ +FREN+EDIYAGIE D+ DAE+ L ++ + K+RFP Sbjct: 122 TYYPGTPSPVVHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFP 181 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + IKP S++G+ RLV AAI+YA AN+R ++TLVHKGNIMK TEG FK WGY+ A E Sbjct: 182 DTSAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAA-E 240 Query: 252 EFGGELIDGGPWLKVKNPNTGK-------------EIVIKDVIADAFLQQILLRPAEYDV 298 ++G ++ + ++K K ++++ DVI D F QQ LL P ++V Sbjct: 241 KYGDKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEV 300 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDEC--ALFEATHGTAPKYAGQDKVNPGSI 356 +A MNLNGDYISDALAAQVGGIGIAPG NI + A+FEATHGTAP++AGQ+K+NP SI Sbjct: 301 VATMNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSI 360 Query: 357 ILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ILS MM ++GW + ++LI G++ AI + VT DF + D A +L S FG+ + + Sbjct: 361 ILSGAMMFDYLGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPD-ATVLSTSGFGEYVAQ 417 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 422 bits (1086), Expect = e-117, Method: Compositional matrix adjust. Identities = 217/421 (51%), Positives = 290/421 (68%), Gaps = 12/421 (2%) Query: 3 SKVVVPAQGKKITL---QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKG 59 KV VPA+G+KI + N +L++PENPI+P I GDGIG DV PA KV++AA A Sbjct: 6 DKVEVPAEGEKIEVVDEDNDELDIPENPIVPIIHGDGIGKDVGPAAQKVLEAA---ANAT 62 Query: 60 ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR 119 R+ISWM ++ GE + + Y ++ LP +T++ I E+RVAIKGPLTTPVG G RSLNVALR Sbjct: 63 GREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHRVAIKGPLTTPVGAGFRSLNVALR 120 Query: 120 QELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFL 179 Q LD Y +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F+ Sbjct: 121 QTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREFV 180 Query: 180 REEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG 239 E+MG + GIGIKP +E G+KRLVR AI+YAI +DRD VTLV KGNIMKFTEG Sbjct: 181 EEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEG 240 Query: 240 AFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPAE 295 F +WG ++A EE+ + + P W + ++ ++++ +ADA LQ + LR E Sbjct: 241 QFTEWGMEVADEEYPDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDE 300 Query: 296 YDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGS 355 + V+A NLNGDY+SDA AQ+GG+GIAPGAN GD L E HG+APK AGQ+ NP + Sbjct: 301 FSVLAMPNLNGDYLSDAAGAQIGGLGIAPGANFGDARVLAEPVHGSAPKRAGQNMANPTA 360 Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ILS +M +MGW +AADL+ +E I++ TVTYD ER ++ A+ L E+ DAI+EN Sbjct: 361 MILSGRLMFDYMGWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVEN 420 Query: 416 M 416 + Sbjct: 421 I 421 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 387 bits (993), Expect = e-106, Method: Compositional matrix adjust. Identities = 199/419 (47%), Positives = 276/419 (65%), Gaps = 13/419 (3%) Query: 4 KVVVPAQGKKITLQN-GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 K + P G+ + G+L VP+ +I YIEGDGIG +V A +KV + AVEKAY R+ Sbjct: 21 KYIDPPSGEYVKYTGPGQLKVPDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQ 80 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I+W EI GEK+ +++G LP ++++++R+ RV +K PL TPVGGG RS+NV LRQ Sbjct: 81 ITWYEIVVGEKAEKLFGNR--LPDQSIEVLRKIRVFLKAPLETPVGGGFRSINVTLRQLF 138 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ED+YAGIEW +S +A K+ +FLR E Sbjct: 139 DLYANIRPVKYFPGLPSPLRRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRRE 198 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 GV IR + GIGIKP S+ GT+R+ R A+++AI N R VT++HKGNI K+TEGAFK Sbjct: 199 FGV-NIR--DDAGIGIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFK 255 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 +W +++AR EF ++ + ++++ D IAD LQQ+L R EYDVI Sbjct: 256 EWAFEVARNEFREHVVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAP 315 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362 NLNGDY+SD A VGG+G+APG ++GD + E HGTAPKY G++ VNP + IL+ E+ Sbjct: 316 NLNGDYVSDEAAGLVGGLGVAPGLDVGDWGMMAEPVHGTAPKYRGKNYVNPTATILALEL 375 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDF-------ERLMDGAKLLKCSEFGDAIIE 414 M R +GW E A+ I+KG+E A T D ER M ++L EF D ++E Sbjct: 376 MFRFLGWREVAEYIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVE 434 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 363 bits (932), Expect = 6e-99, Method: Compositional matrix adjust. Identities = 199/412 (48%), Positives = 265/412 (64%), Gaps = 14/412 (3%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 P++G+ +NGKL VP+N I+ Y +GDGIG ++ + KV+DAAV+KAY G R+I W E Sbjct: 14 PSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWE 73 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYIC 127 + GE++ + G LP TL + RV +KGPLTTPVGGG RSLNV LR LDLY Sbjct: 74 VTAGEEAQKECGS--LLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVLDLYSN 131 Query: 128 LRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK 187 +RPV++Y G P+P HPE D VIFREN+ED+YAGIEW DS +A+K+ FL++E G Sbjct: 132 VRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFG--- 187 Query: 188 IRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247 I GIGIKP S+ T+R VR A+E+AI N VT++HKGNIMK+TEGAF+ W Y Sbjct: 188 IELTPDTGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYD 247 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGK----EIVIKDVIADAFLQQILLRPAEYDVIACMN 303 L EF ++ +V GK +I++ D IAD LQQI+ RP EY+VI N Sbjct: 248 LILSEFRDYVVTEE---EVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPN 304 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363 LNGDYISD A VGGIG+A G ++GD A+ E HG+APKYAG++ +NP + ILS + Sbjct: 305 LNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSGMYL 364 Query: 364 LR-HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 L +GW E L+ ++ AI K VTYD R M G + +E+ D +++ Sbjct: 365 LSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVD 416 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 357 bits (915), Expect = 7e-97, Method: Compositional matrix adjust. Identities = 191/417 (45%), Positives = 271/417 (64%), Gaps = 14/417 (3%) Query: 2 ESKVVVPAQGKKITLQNGK-LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 E K +P +G+ I L+ K L VP+NPIIP+IEGDGIG ++T AML +++ AVEK Y G Sbjct: 13 EGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGS 72 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +KI W+E+ G+K+ + G+ LP ETLD+++E V IKGPL TPVG G+RS+N ALR+ Sbjct: 73 KKIYWVELLAGDKAEEKTGER--LPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRR 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 D Y +RPV Y+ G +P+ +PE D+V+FREN++D+YAG+E+ A + +A+KV +FL Sbjct: 131 AFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLI 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 +EMG K+ FPE GI +KP SE TKR VR A+ YA+ N++ +V ++ KGNIMK TEGA Sbjct: 190 KEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGA 249 Query: 241 FKDWGYQLARE-EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 F +W +++A E EF G+++ P G ++ + VI D L Q++L+P +DVI Sbjct: 250 FINWAFEVAEEPEFKGKVVTD----PEAEPGEG-QVKLTKVITDQMLMQLVLKPEAWDVI 304 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILS 359 NLNGDY+SD A+ +GG G P NIGD ALFE+THGTA AG+ NP S+ LS Sbjct: 305 IAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLS 364 Query: 360 AEMMLRHMGWTEAA----DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 MML ++GW EAA D + + + I + F++ AK + EF + I Sbjct: 365 GAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEI 421 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 332 bits (852), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 157/217 (72%), Positives = 183/217 (84%), Gaps = 1/217 (0%) Query: 4 KVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 K+ VPA G KIT+ + LNVP NPIIP+IEGDGIG+D++P M+KVVDAAV+KAY GERK Sbjct: 5 KIQVPATGDKITVNADTSLNVPNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERK 64 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 ISWME+Y GEK+TQVY QD WLP ETLD +++Y V+IKGPLTTPVGGGIRSLNVALRQ+L Sbjct: 65 ISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQL 124 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY+CLRPVR+++G PSPVK P DM IFRENSEDIYAGIEWKA S +A KVIKFL+EE Sbjct: 125 DLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEE 184 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 219 MGV KIRF + CGIG+KP S+EGTKRL R A+ A A Sbjct: 185 MGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 272 bits (695), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 163/367 (44%), Positives = 218/367 (59%), Gaps = 38/367 (10%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +VT AM V++A+ + W+ + G + + YG LP + Sbjct: 5 VTLIPGDGIGPEVTRAMTTVLEAS-------GVDLEWIRVEAGVEVIEKYGTP--LPPQV 55 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L+ IRE RVAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + D Sbjct: 56 LESIRETRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQD---ID 112 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF-PEHCGIGIKPCSEEGTK 207 +V+ REN+ED+YAGIE++ + +A REEM +F E IGIKP SE G++ Sbjct: 113 LVVVRENTEDLYAGIEFERGTPEAAHA----REEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+V+ A EYA N R VT VHK NIMKFT+G F ++A+E Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY--------------- 213 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I +D+I D Q++ +P YDV+ NL GD ISD A +GG+G+APGAN Sbjct: 214 -----PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGAN 268 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NA 386 IGD A+FEA HG+APKYAGQ+KVNP ++ILS MMLR++G EAA + ++ I Sbjct: 269 IGDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAEG 328 Query: 387 KTVTYDF 393 K VTYD Sbjct: 329 KYVTYDL 335 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 215 bits (547), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 142/395 (35%), Positives = 215/395 (54%), Gaps = 46/395 (11%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDG G ++ A V+D A A + W G+ + + G+ LPA T Sbjct: 6 VTLIAGDGSGPELVAAARTVLDTAAGSA---GFHLDWDVRPAGQGALRSVGE--LLPAST 60 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 LD IR VA+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + D Sbjct: 61 LDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAVDSG---ID 117 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI----KPCSEE 204 +V+ REN+ED+Y+G+E+ ADS D V+ E G H GI KP + Sbjct: 118 VVVVRENTEDVYSGLEYPADS-DGAAVVSATLSEFG--------HADPGIAFSLKPITPG 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF--TEGAFKDWGYQLAREEFGGELIDGGP 262 G++R+V A+++A N R V + ++ ++ TEG F ++ ARE Sbjct: 169 GSRRIVAFALDHARKNGRRKVEV--GADVYRYPRTEGLF----FEAARE----------- 211 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 L + P+ V V+ D+ ++ PA+ DV+ NL GD ISD AA VGG+G+ Sbjct: 212 -LGPEYPDIVTATVPVTVLCDSLVRD----PADRDVLVLPNLYGDVISDVTAALVGGLGM 266 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 APGANIGD A+FEATHG+AP++AG +++NP ++ILS M+L H+G A I + Sbjct: 267 APGANIGDRTAVFEATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRS 326 Query: 383 AI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++VT+D A+ + + + +A+IE + Sbjct: 327 VLEEGRSVTFDLLPPDRAARAVTTTAYAEAVIERL 361 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 210 bits (534), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 146/408 (35%), Positives = 212/408 (51%), Gaps = 61/408 (14%) Query: 14 ITLQNGK-LNVPEN--PIIPYIEGDGIGVDVTPAMLKVVDAA-VEKAYKGERKISWMEIY 69 IT + GK ++V E+ +I I GDGIG + A LKV++AA AY E+ Sbjct: 4 ITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAY---------EVR 54 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 S G +P ET++ IR+ RV +KGPL TPVG G +S NV LR+ + Y +R Sbjct: 55 EAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVR 114 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PVR + P+P + D+V+ REN ED+YAGIE + A+ Sbjct: 115 PVREFPNVPTPYAGRGI-DLVVVRENVEDLYAGIEHMQTPSVAQT--------------- 158 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 +K S +G++++VR A E A A R V K NIMK EG K Q+A Sbjct: 159 --------LKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVA 210 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 +E +I +I D Q++ RP +++VI N+NGD + Sbjct: 211 QEY--------------------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDIL 250 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD + +GG+G AP ANIG+E A+FEA HG+APKYAG++ +NP +++LSA MMLR++ Sbjct: 251 SDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEE 310 Query: 370 TEAADLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI + + + +T D GA K +E+ +AII+N+ Sbjct: 311 FATADLIENALLYTLEEGRVLTGDVVGYDRGA---KTTEYTEAIIQNL 355 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 205 bits (521), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 135/391 (34%), Positives = 197/391 (50%), Gaps = 33/391 (8%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG G ++ A V+D A A KI W G+++ + + LP T Sbjct: 6 VTLVPGDGSGPELVDAARSVLDHA---ARLSGFKIDWDVHQAGQRA--LAESESLLPDAT 60 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-- 146 L+ IR A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR S + PE Sbjct: 61 LNSIRTNGAALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEEPERPH 119 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAG+E+ S A V++ L G P + +KP + G Sbjct: 120 VDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTPHGC 175 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+V A +A + R V V TEG F ++A Sbjct: 176 ERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVA----------------A 219 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++P+ I + V A ++ P +DV+ NL GD ISD AA VG +G+APGA Sbjct: 220 RHPS----IASRTVPVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGA 275 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG A+FEATHG+AP++AG ++NP ++I S M+L H+G E A I +E + A Sbjct: 276 NIGAHHAVFEATHGSAPEFAGSGRLNPTALIFSGCMLLDHLGEHETAARIRAAVEDVVAA 335 Query: 387 -KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +T+D A EF A+ + + Sbjct: 336 GEVLTFDLLAPQRSADAATTVEFTRAVTDRL 366 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 201 bits (511), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 127/367 (34%), Positives = 192/367 (52%), Gaps = 58/367 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYK-GERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ AAV++ +K + I W + + T+ +P Sbjct: 1979 VALIPGDGIGPEIS--------AAVQEIFKFADVPIKWESVDVTPRPTE--DGRFRMPQS 2028 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 +LD+IR++ + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G +P K+ Sbjct: 2029 SLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYKN---V 2085 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V REN+E Y+GIE + V++ IK +EE ++ Sbjct: 2086 DLVTVRENTEGEYSGIE----HVIVDGVVQ-------------------SIKLITEEASR 2122 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A +YA N R SVT VHK NIM+ ++G F ++ REE Sbjct: 2123 RVARFAFQYAKDNGRRSVTAVHKANIMRMSDGLF----LRVCREEAAHH----------- 2167 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +EI D+ D ++ P +DV+ NL GD +SD A +GG+G+ P N Sbjct: 2168 -----REIEFCDMFLDTVCLNLVQDPTRFDVLVMPNLYGDILSDLAAGLIGGLGVTPSGN 2222 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN-A 386 IG+ A+FE+ HGTAP AGQD+ NP +++ SA MMLR+M + ADLI + I A Sbjct: 2223 IGETGAIFESVHGTAPDIAGQDRANPTALLFSAIMMLRYMNLNKHADLIESAVLATIREA 2282 Query: 387 KTVTYDF 393 K +T D Sbjct: 2283 KYLTADL 2289 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 197 bits (502), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 141/389 (36%), Positives = 198/389 (50%), Gaps = 66/389 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I+GDG+G DV A L V+DA V+K + + I ++ G + + YG + LP ET Sbjct: 8 VAVIKGDGVGPDVINASLLVLDA-VKKKFNLD--IEYVPAVAGLNTVEKYGTN--LPKET 62 Query: 89 LDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 LD ++E +KGP TTP G + S NV +R+ DLY +RP + PS P + Sbjct: 63 LDTLKETDCVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--KPNV- 119 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 DMVI REN+E +Y+G+++ R + IGI+ + + + Sbjct: 120 DMVIVRENTEGMYSGLDF-----------------------RVNQETTIGIRVITRKACE 156 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+V+ A + A + + VTLVHKGN++K ++G FKD Y+ A+ K Sbjct: 157 RIVKYAFKLA-ESRKKHVTLVHKGNVLKVSDGMFKDIFYEEAK----------------K 199 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +P+ + D DA Q + +P YDVI NL GD ISD A VGGIG AN Sbjct: 200 HPDVKAD----DAHVDAITQWFIKQPEFYDVIVTENLFGDIISDEAAMVVGGIGTGASAN 255 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA----DLIVKGMEGA 383 IGD+ A+FE HG+ PKY G DKVNP I+S +MML M + EA D + K +E Sbjct: 256 IGDKYAMFEPIHGSVPKYTGMDKVNPIGTIMSVKMMLDWMDYKEAGKAIEDAVYKVLE-- 313 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAI 412 K +TYD KCSE G I Sbjct: 314 -EGKILTYDL------GGTAKCSEVGKEI 335 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 194 bits (494), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 123/387 (31%), Positives = 195/387 (50%), Gaps = 62/387 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +VT A ++V++A K W G ++ + Y + ++P E Sbjct: 5 ITLIPGDGIGPEVTSAAVRVLEAT-------GLKFEWESFAAGAEAYEKYKE--YIPKEL 55 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + I R+ +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + ++P + D Sbjct: 56 NESIERTRIGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHT--RYPGV-D 112 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+E +Y+GIE + E +K +E+ + R Sbjct: 113 LVVVRENTEGLYSGIEHEVVPGVVES-----------------------LKIITEKASTR 149 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + + A YA R + +HK NIMK ++G F +++E Sbjct: 150 ISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY---------------- 193 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 EI+ + I D Q+++ P +YD++ NL GD +SD A VGG+G+APGANI Sbjct: 194 ----PEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPGANI 249 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN-AK 387 G+ ++FEA HG+AP AG++ NP ++I S +MLRH+ +AA+ + + K Sbjct: 250 GERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRHLDEQDAANRVKAAVHHVYREGK 309 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIE 414 +T D M G SEF D ++E Sbjct: 310 HLTRD----MGGTT--STSEFADKVVE 330 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 191 bits (484), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 138/409 (33%), Positives = 203/409 (49%), Gaps = 62/409 (15%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A K + NGK ++ I GDGIG ++ + ++++A I W E+ Sbjct: 9 ATMKYVVTPNGK------KLVTLIPGDGIGPEIVESACRLIEAV-------GAPIEW-EV 54 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 S G +P +T++ I+ RV +KGPL TPVG G +S NV LR+ + + + Sbjct: 55 RRAGASVFREGIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRKLFEAFANV 114 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RPVR P+P + + D+V+ REN ED+YA IE+ RE GV Sbjct: 115 RPVRELPSVPTPYRGRNI-DLVVVRENIEDLYAAIEY--------------RETPGVT-- 157 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 I K S +G+++++R A E A A R VT K NI+K TEG W +Q Sbjct: 158 -------IAHKLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEG----W-FQH 205 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 EE E D I +I D Q++ P +++VI NLNGD Sbjct: 206 IFEEIASEYPD---------------IEANHLIIDNCAHQLVKAPEQFEVIVTTNLNGDI 250 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 ISD + VGG+G A N G E A+FE HGTAPKYAG++ +NP ++IL+A MMLR++ Sbjct: 251 ISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYID 310 Query: 369 WTEAADLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E A+ I + + + K +T D ++ + + + F DAII N+ Sbjct: 311 EFETAETIEQALIVTLEEGKALTRD---VVGDERAVSTTAFTDAIIANL 356 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 181 bits (458), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 126/384 (32%), Positives = 187/384 (48%), Gaps = 55/384 (14%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 93 GDGIG ++ A+L ++ K E +I I GEK V + ++ + I Sbjct: 12 GDGIGPEIMEAVLYILR-------KAEARIRLETIEVGEK-LYVKHYSSGISEQSWESIE 63 Query: 94 EYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVIF 152 V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + HP L ++ I Sbjct: 64 RTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL--HPNL-NLTII 120 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 212 REN ED+YAGIE++ E V K S G ++++R Sbjct: 121 RENEEDLYAGIEYRQTHNMYESV-----------------------KLISRTGCEKIIRY 157 Query: 213 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTG 272 A EYA+ N+R VT + K NIMKF++G F ++A+E + ++ N + Sbjct: 158 AFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKE-----------YPQINNEH-- 204 Query: 273 KEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC 332 I D ++ +P +DVI NL GD ISD A G +G+A ANIG+ Sbjct: 205 -------YIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGEHY 257 Query: 333 ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYD 392 A+FEA HG+AP AGQD NP ++ +A MML H+G + A LI + I T D Sbjct: 258 AMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGMHTAD 317 Query: 393 FERLMDGAKLLKCSEFGDAIIENM 416 K + EF + +++ + Sbjct: 318 IYNKDHSTKKVGTKEFAEEVVKRL 341 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 180 bits (457), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 129/385 (33%), Positives = 192/385 (49%), Gaps = 57/385 (14%) Query: 34 GDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI 92 GDGIG ++ A++ V+ +AAV ++ +EI GEK Y + +T I Sbjct: 12 GDGIGPEIMEAVVYVLKEAAVP------LRLETIEI--GEKLYNKY-YTYGITEDTWSQI 62 Query: 93 REYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVI 151 + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + PE+ D+VI Sbjct: 63 FRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSA--PEI-DVVI 119 Query: 152 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 211 REN ED+YAGIE+ +AD + +K + S G+++++R Sbjct: 120 IRENEEDLYAGIEYH-HTADTYESVKLI----------------------SRSGSEKIIR 156 Query: 212 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNT 271 A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 157 FAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQY------------------- 197 Query: 272 GKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE 331 I + + D +++ P ++DVI NL GD +SD A G IG+A ANIG + Sbjct: 198 -SNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIGLAGSANIGKD 256 Query: 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTY 391 A+FEA HG+AP AGQ+ NP ++ +A MML H+G TE A I ++ I T Sbjct: 257 YAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDGIHTA 316 Query: 392 DFERLMDGAKLLKCSEFGDAIIENM 416 D + + EF AII N+ Sbjct: 317 DIYNPSISSTKVGTKEFAQAIINNL 341 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 180 bits (456), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 132/385 (34%), Positives = 185/385 (48%), Gaps = 55/385 (14%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 I GDGIG ++ +++ V+DA W Y G + G LP ET+ Sbjct: 18 IPGDGIGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGDP--LPRETIQS 68 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 151 I ++A+KGPLTTP GGG RS+NV LR+E +L+ +RP T P E D+ + Sbjct: 69 IHHNKLALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPAL----TLIPGGRFENVDITL 124 Query: 152 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 211 REN + YA E D P + + G R++R Sbjct: 125 IRENLDGFYAAFEHYMPIGDD------------------PHAVAMCAGFNTRTGCHRIIR 166 Query: 212 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNT 271 A EYA+ N R VTLVHK NI+K G F + G ++A+E G Sbjct: 167 YAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEG----------------- 209 Query: 272 GKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE 331 I ++ I DA Q++L P +DVI NL GD +SD +A +GG+G+APG NIG + Sbjct: 210 --RIAFEERIVDACAMQLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQ 267 Query: 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTY 391 A+FEA HG+AP AG+ NP +++L+A MML H+G T+ A + AI T+ Sbjct: 268 AAIFEAVHGSAPDIAGKGIANPLALMLAAAMMLDHVGKTDLATR----LRNAIRITTLE- 322 Query: 392 DFERLMDGAKLLKCSEFGDAIIENM 416 D R D K E A+I + Sbjct: 323 DGIRTPDLGGTAKTRELTQALISRI 347 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 178 bits (451), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 123/393 (31%), Positives = 198/393 (50%), Gaps = 69/393 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + IEGDGIG +++ ++ + AA I W + + + + +P + Sbjct: 57 VTLIEGDGIGPEISQSVKDIFSAA-------NAPIKWEPV---DVTPILKDGKTAIPDDA 106 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G +P + D Sbjct: 107 IESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPYDN---VD 163 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 V+ REN+E Y+GIE + V++ IK ++E ++R Sbjct: 164 TVLIRENTEGEYSGIEHVV----VDGVVQ-------------------SIKLITKEASER 200 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELIDGGPWL 264 ++R A +YA + ++ V +VHK IMK ++G F + ++A++ EF EL+D Sbjct: 201 VLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLK 260 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 V +P + ++L+ P NL GD +SD A +GG+G+ P Sbjct: 261 IVTDPT-------------PYNDKVLVMP---------NLYGDILSDMCAGLIGGLGLTP 298 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A I K + + Sbjct: 299 SGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAGRIQKAIFDTL 358 Query: 385 -NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +T D G K K SE+ +AI++ + Sbjct: 359 AEGKALTGDL-----GGK-AKTSEYAEAIMKKL 385 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 177 bits (448), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 119/336 (35%), Positives = 171/336 (50%), Gaps = 58/336 (17%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY--GQDVWLPAETLDL 91 GDGIG ++T A++ ++ AA ++E+ GE QVY G +P E D Sbjct: 29 GDGIGPEITAAVMSILSAA-----GAHLDAEYVEV--GE---QVYLRGNTSGIPQEAWDS 78 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 151 I RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ + +HP++ D+VI Sbjct: 79 IARTRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYKPIVT-TRHPDM-DVVI 136 Query: 152 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 211 REN ED+YAGIE + + D + +K + + G++R+ R Sbjct: 137 VRENEEDLYAGIEHR-QTQDVAQCLKLI----------------------TRSGSERIAR 173 Query: 212 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNT 271 A EYA + R +T + K NIMK T+G F ++ARE Sbjct: 174 YAFEYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY------------------- 214 Query: 272 GKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE 331 EI I D + + RP +YDV+ NL GD +SD A G +G+ NIG Sbjct: 215 -PEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQMTGSVGLGGSVNIGSG 273 Query: 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 A+FEA HG+AP A +D NP ++L+A MLRH+ Sbjct: 274 GAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHL 308 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 176 bits (446), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 123/386 (31%), Positives = 189/386 (48%), Gaps = 63/386 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +++ A++K+ DAA ER ++ + Q G +P+E Sbjct: 34 VTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVT---------AIQGPGGKWMIPSEA 84 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + + + ++ +KGPL TP+ G S+N+ LR+ DLY +RP +G +P + Sbjct: 85 KESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTD---VN 141 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V REN+E Y+GIE + V++ IK +E +KR Sbjct: 142 IVTIRENTEGEYSGIE----HVIVDGVVQ-------------------SIKLITEGASKR 178 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + A EYA N R +VT VHK NIM+ ++G F Q RE Sbjct: 179 IAEFAFEYARNNHRSNVTAVHKANIMRMSDGLF----LQKCREV---------------- 218 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 + K+I ++ D ++ P+++DV+ NL GD +SD A +GG+G+ P NI Sbjct: 219 AESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNI 278 Query: 329 G-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NA 386 G + A+FE+ HGTAP AG+D NP +++LSA MMLRHMG + A I I + Sbjct: 279 GANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDG 338 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAI 412 K++T D KCS+F + I Sbjct: 339 KSLTKDL------GGNAKCSDFTEEI 358 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 174 bits (442), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 122/403 (30%), Positives = 198/403 (49%), Gaps = 67/403 (16%) Query: 15 TLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKS 74 TL+N + + + I GDGIG +++ ++ +V A + I W Sbjct: 12 TLRNYSSSTSKIQKVTLIPGDGIGPEISESVKRVFSAV-------KAPIEW--------E 56 Query: 75 TQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYY 134 T V + + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 57 TVVVDANTGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCLSI 116 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G + + + V+ REN+E Y+GIE + A+ Sbjct: 117 PGHKTRYNN---VNTVVVRENTEGEYSGIENQPVKGVAQS-------------------- 153 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F + RE Sbjct: 154 ---IKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLF----VKSCRE--- 203 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 + + P+ I +++ D Q++L P + DV+ NL GD +SD A Sbjct: 204 ---------VSTRYPS----IKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDLCA 250 Query: 315 AQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 +GG+G+ P NIG+ A+FEA HGTAP AG++K NP ++ILS+ MMLRH+G A Sbjct: 251 GLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFHEA 310 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I E A+ T+T + D CSE+ D +++ + Sbjct: 311 SII----ENAV-LNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 172 bits (435), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 117/403 (29%), Positives = 202/403 (50%), Gaps = 39/403 (9%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEK 73 I + + VP+ I YI+GDGIG ++T AM+ VV++A+E AY+G R I W +I G + Sbjct: 11 IEFTDSGMVVPDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTE 70 Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRY 133 + + +G ++P +++ I++ +A+K L R LN LR+ L LY +R ++Y Sbjct: 71 AYEKFG--TYVPEDSIKEIQKMYIAMKSTLN--FMPDKRDLNTILRKRLGLYSNIRILKY 126 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +G PV ++ I R+++ + + + S + +I+F+ + G + Sbjct: 127 IEGMDIPVNTFNRLNLTIIRDSTPNSHI---FYHSSESTDDLIRFISDNYG---LNITPD 180 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 GI + P S+ T+++ + A+ Y+ N + +T++ +F ++ A+E+ Sbjct: 181 SGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILESQQNHEFANWCIEEAS---AQEDV 237 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 G E+ LK + F+++++ P +++VI N+ + D L Sbjct: 238 GYEV------LKTRE----------------FMKRLISSPEDFEVILVDNVLSQTLVDYL 275 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 A G I I G++IGDECA+FEA + P AG D +P S ILS ML H+GW EAA Sbjct: 276 A---GTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEAA 332 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I + A + D D + +KCSEF II+ M Sbjct: 333 QIIENAISAAFRDNKIPKDINTRPDISP-IKCSEFSSEIIKRM 374 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 170 bits (431), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 130/390 (33%), Positives = 185/390 (47%), Gaps = 67/390 (17%) Query: 34 GDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVY--GQDVWLPAETLD 90 GDGIG ++ A LKV+ +A E +EI E +VY G + + + Sbjct: 11 GDGIGPEIMDATLKVILEAGAE-----------LEIEKIEIGFKVYSMGNPSGIEPSSWE 59 Query: 91 LIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 150 ++ +V +K P+TTP GGG +SLNV +R+ L LY +RP Y KHP + D+V Sbjct: 60 SLKRTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISYAPFIH-TKHPGI-DLV 117 Query: 151 IFRENSEDIYAGIEWK--ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 I REN ED+Y GIE + DS A K++ + +GT+R Sbjct: 118 IIRENEEDLYGGIEHRQGVDSFQALKIM-------------------------TRQGTER 152 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 ++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 153 IIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKE----------------Y 196 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 P KE I D I A L P +DV+ NL GD +SD G +G+ ANI Sbjct: 197 PQIEKEHWIID-IGSAKLAD---NPQSFDVLVLANLYGDILSDVAVQIAGSVGLGASANI 252 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G E ++FEA HG+AP+ AGQ+ NP ++L+A ML H+G AD + I Sbjct: 253 GHEYSMFEAIHGSAPRRAGQNVANPSGLLLAAVQMLIHIGQNAVADRVYNAWLKTIEEGI 312 Query: 389 VTYDFERLMDGAKLLK--CSEFGDAIIENM 416 TYD R +G +K EF +I+N+ Sbjct: 313 HTYDIFR--EGVSKVKVGTREFARHVIKNL 340 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 168 bits (426), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 121/404 (29%), Positives = 192/404 (47%), Gaps = 58/404 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + + GDGIG V P ++V++A +A I W E + E + LP Sbjct: 4 PTVVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGW-ECWCNEGNA--------LPD 54 Query: 87 ETLDLIREYRVAIKGPLTTP-------------VGGGIRSLN--VALRQELDLYICLRPV 131 T+ L+R++++ + G +T+ G G+ + V +RQ +L +C+RP Sbjct: 55 RTIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPC 114 Query: 132 RYYQGTP---------SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 + G P + P++ D+V+FR+N+E +YAG+EW + + ++ Sbjct: 115 LSFPGNPLNFIRQTTCGGFEEPQV-DVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKF 173 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 E + ++ +++ +R+ AA ++A +VT+ K N+++ T G + Sbjct: 174 AAFANTP-GEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMME 232 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + Q+ ++ EI + DA + P EY VI Sbjct: 233 EVAKQVQKQY--------------------PEIALWSTNIDAQTMWLTKNPEEYGVIVAS 272 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK--VNPGSIILSA 360 NL GD ISDA A VGG+G A NIGDE A+FE THG+APKYA + VNP ++ILSA Sbjct: 273 NLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSA 332 Query: 361 EMMLRHMGWTEAADLIVKGMEGAIN-AKTVTYDFERLMDGAKLL 403 MML H+G +E AD I K + + K TYD R+ G K L Sbjct: 333 AMMLDHIGESEKADRIRKAIADVVKEGKVRTYDMMRIAGGPKSL 376 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 168 bits (425), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 123/393 (31%), Positives = 183/393 (46%), Gaps = 67/393 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + +IEGDGIG +++ ++ K+ AA I W + S +P Sbjct: 39 VSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESC---DVSPIFVNGLTTIPDPA 88 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + I + VA+KGPL TP+G G RSLN+ LR+ L+ +RP + +G + E D Sbjct: 89 VQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---ENVD 145 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+E Y+GIE + IK + + ++R Sbjct: 146 LVLIRENTEGEYSGIEHIVCPGVVQS-----------------------IKLITRDASER 182 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELIDGGPWL 264 ++R A EYA A R V +VHK I + +G F + +L++E ELID Sbjct: 183 VIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLK 242 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA-QVGGIGIA 323 V NP+ DA V C NL GD +SD + G +G+ Sbjct: 243 VVTNPS---------AYTDA-------------VSVCPNLYGDILSDLNSGLSAGSLGLT 280 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 P ANIG + ++FEA HG+AP AGQDK NP +++LS+ MML HMG T AD I + A Sbjct: 281 PSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQI----QNA 336 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + R D A S F +A+I+ + Sbjct: 337 VLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 166 bits (420), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 117/396 (29%), Positives = 192/396 (48%), Gaps = 79/396 (19%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV---YGQDVWLPAET 88 IEGDGIG +V P +K+++ ++ EI GE + YG LP +T Sbjct: 7 IEGDGIGKEVIPEAIKILN-----------ELGEFEIIKGEAGLECLKKYGN--ALPEDT 53 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLN---VALRQELDLYICLRPVRYY-------QGTP 138 ++ +E + + G +T+P G +++ + LR+ LY +RP+ + + Sbjct: 54 IEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIAD 113 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D+VI REN+ED+Y G E + D+A AE+VI Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVGRERLENDTAIAERVI--------------------- 152 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +G++R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 153 ----TRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKH------ 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I D + D+ ++ P ++DVI N+ GD +SD +A + Sbjct: 203 ---------------YNIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP ANIGD+ ALFE HG+AP AG+ NP + ILS M+ ++G E DLI Sbjct: 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + ++ + K VT D LK + GD I+ Sbjct: 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEIL 337 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 165 bits (417), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 122/390 (31%), Positives = 187/390 (47%), Gaps = 65/390 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG----EKSTQVYGQD--- 81 + Y+ GD G D+ L V+ + I W+ G EKS +GQ Sbjct: 17 VCYMPGDDSGFDMMEGALVVL-------LSMDLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 82 -VWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P ET+D IR + +T+ G G +S + +RQ DLYI LRP + S Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPAKTLPDLGS 129 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHC 194 P+K D+V+FREN+ED+Y+ +E+ L EEM G+++ R Sbjct: 130 PLKGDPKIDLVLFRENTEDLYSAVEFHP-----------LPEEMFNLHKGMERFRKMGDV 178 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE--E 252 + + S G +R++RAA EYA + R V +K N+++ T+G K ++A+E + Sbjct: 179 AVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQ 238 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +G I+ ADA ++ P +Y VI N+ GD +SD Sbjct: 239 YGITGIEEN--------------------ADATAMWLIKNPQDYQVIVTSNVFGDILSDE 278 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + GG+G AP NIG+ A+FE G+ PKYA Q +VNP +++L+++MML ++G +A Sbjct: 279 ASQLTGGLGFAPSGNIGENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLGLDQA 338 Query: 373 ADLIVKGMEGAIN-------AKTVTYDFER 395 I E AIN KT+TYD R Sbjct: 339 GQKI----EWAINEVLKENRPKTLTYDILR 364 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 164 bits (415), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 114/366 (31%), Positives = 178/366 (48%), Gaps = 62/366 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIGV+V A L +++ + + ++ G+ + G LP ET Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TALPEET 56 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L+ + E R + G G + V LR+E DL+ LRPV+ G P +P+L D Sbjct: 57 LEAVGEARATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVP--CLYPDL-D 109 Query: 149 MVIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 VI REN+ED+Y G E + + A A+++I + ++ Sbjct: 110 FVIVRENTEDLYVGDEEYTPEGAVAKRII-------------------------TRTASR 144 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ + A +YA VT VHK N++K T+G F+D Y++A E P ++ Sbjct: 145 RISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY---------PQMEAT 195 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 D DA ++ +P E+ I NL GD +SD A +GG+G+AP AN Sbjct: 196 -----------DYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAPSAN 244 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG++ ALFE HG+AP+ AG++ NP ++IL+ +ML+H+ + A I K ++ + Sbjct: 245 IGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTLAEG 304 Query: 388 TVTYDF 393 VT D Sbjct: 305 LVTPDL 310 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 60/392 (15%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + GDG+G ++ ++L+++ A E +I +EI G+K + G + Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA-----GAEIQIDTIEI--GQKIYE-KGWPSGISD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P Sbjct: 54 SGWETLKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDPK----- 108 Query: 147 TDMVIFRENSEDIYAGIEWKA--DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN ED+Y+GIE++ D+ + KVI +E Sbjct: 109 MDIVIIRENEEDLYSGIEYRQTLDTYNCTKVI-------------------------TES 143 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 144 TSERICRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALE------------- 190 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 P+ E I D+ A +I P ++DVI +NL GD ISD A G +G+ Sbjct: 191 ---YPDIESENYIIDIGA----ARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGLGG 243 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIG+E A+FEA HG+AP A QD NP ++ +A ML ++G E A + + Sbjct: 244 SINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTL 303 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D + + +F + II N+ Sbjct: 304 KSGVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 158 bits (400), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 114/350 (32%), Positives = 168/350 (48%), Gaps = 64/350 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +V AVE+ + E Y +V G +P E Sbjct: 41 VTLIPGDGIG--------PLVTGAVEQVMEAMHAPVHFERY------EVLGNMRKVPEEV 86 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 ++ ++ +V +KG L TPVGGG+ SLN+ LR+ELD++ L P V E D Sbjct: 87 IESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNC---INVPGLVTRHENVD 143 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+E Y+G+E +V+ + E + V K CSE R Sbjct: 144 IVVIRENTEGEYSGLE--------HEVVPGVVESLKVIT-----------KFCSE----R 180 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + R A EYA N+R VT VHK NIMK +G F + ++A+ G Sbjct: 181 IARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG-------------- 226 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 I ++I D Q++ +P ++DV+ NL G+ I++ A GG G+ PG N+ Sbjct: 227 ------ITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNV 280 Query: 329 GDECALFE--ATHGTA--PKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G E A+FE A+ G K Q K NP +++LS+ MMLRH+ + AD Sbjct: 281 GAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFAD 330 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 157 bits (398), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 57/366 (15%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 ++GDGIG +V +ML+V+ K + ++ E + + ++P T+ + Sbjct: 8 MKGDGIGPEVVDSMLRVL-----KECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKI 62 Query: 92 IREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 150 + E KGP TT PV G RS+ V LRQ+ DLY +RP + Y K D V Sbjct: 63 LEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLTPDRK----LDCV 118 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 FRE +E +Y G+E K + I I+ + +G++RL+ Sbjct: 119 CFREATEGLYTGVEAK-----------------------ITDDAAIAIRKITRQGSRRLI 155 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 +A+++A + + V K NI+K T+G F W + + Sbjct: 156 DSAVDWANKFNMKKMVAVTKRNILKQTDGIF---------------------WDETQKAV 194 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAPGANI 328 G +I + ++ D QQ+++ +++ V+ NL D IS+ +A VG IG+ ANI Sbjct: 195 EGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELASALVGSIGLIYSANI 254 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN-AK 387 GD A+FEA HG+AP++AGQ+KVNP + +LS M ++G + D I E IN K Sbjct: 255 GDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMADYLGERDVRDAIFAATEQVINEGK 314 Query: 388 TVTYDF 393 VT+D Sbjct: 315 AVTWDI 320 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 118/360 (32%), Positives = 176/360 (48%), Gaps = 69/360 (19%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I IEGDGIG +V PA +V++A + ++E G ++ + G V P ET Sbjct: 5 ICLIEGDGIGHEVIPAARRVLEAT-------GLPLEFVEAEAGWETFERRGTSV--PEET 55 Query: 89 LDLIREYRVAIKGPLTTPVG------GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 ++ I + G T+P G IR L R+ LDLY +RP + P P Sbjct: 56 VEKILSCHATLFGAATSPTRKVPGFFGAIRYL----RRRLDLYANVRPAK---SRPVPGS 108 Query: 143 HPELTDMVIFRENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 P + D+VI REN+E +Y E + D A A+ VI Sbjct: 109 RPGV-DLVIVRENTEGLYVEQERRYLDVAIADAVI------------------------- 142 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S++ ++R+ RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 143 SKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKD---------F 193 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 P + V+ D+I D Q+++RP +DVI NL GD +SD A VGG+G Sbjct: 194 PLVNVQ-----------DIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLG 242 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +AP NIGD A+FE HG+AP AG+ NP + ILSA MML ++G EAA + K ++ Sbjct: 243 LAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVD 302 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 103/282 (36%), Positives = 147/282 (52%), Gaps = 46/282 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW----- 83 + I GDG G ++ A +V++A W Q G DV Sbjct: 5 VTLIRGDGTGPELAEATRRVLEAT-------GVAFDW--------DIQDAGVDVMEQLGT 49 Query: 84 -LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 LP L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S + Sbjct: 50 PLPDSVLESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRFE 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D+V+ REN+ED+YAGIE++ + + ++ +L ++ I+ P GI IKP S Sbjct: 110 N---IDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEP--GGISIKPMS 164 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G++R+VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 165 VPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEY---------- 214 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 +I D I D Q++ +P YDV+ NL Sbjct: 215 ----------PDIEFDDRIVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 154 bits (389), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 123/392 (31%), Positives = 181/392 (46%), Gaps = 71/392 (18%) Query: 34 GDGIGVDVTPAMLKVV-----DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 GDG+G ++ A+L ++ D ++E G + Y E ++ + W Sbjct: 15 GDGVGPEIMEAVLFILKEARADVSIETVDIGHNQ------YKKEWTSGI-APSAW----- 62 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV---KHP 144 + I R+ +K P TP G G +SLNVALRQ L LY+ +RP V Y+ PV KHP Sbjct: 63 -ESISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYF-----PVVGTKHP 116 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 +L D+VI REN ED Y+G+E K S D + +K I + SE Sbjct: 117 DL-DVVIIRENEEDTYSGVEHKL-SEDTHECVK------------------ISTRSASE- 155 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++ A YA A++R VT K NIMK T+G ++A+ G P Sbjct: 156 ---KICAYAFNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAK---------GYP-- 201 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I I D + +I P ++DV+ NL GD +SD ++ G IG+ Sbjct: 202 ---------DIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVSLSSGSIGLTG 252 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIGD A+FEA HG+AP AG++ NP ++ +A ML H+G + A +I + Sbjct: 253 SANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQLDKAGVIRNAFLKTL 312 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + EF AI+ N+ Sbjct: 313 EDGVHTADIYSEKTSLRRASTMEFAQAIVGNL 344 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 152 bits (385), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 116/403 (28%), Positives = 177/403 (43%), Gaps = 77/403 (19%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW--MEIYT 70 + T K + +N + G GIG +++ A+ + AA + I W EIYT Sbjct: 291 RYTFSQKKKSQKQNHKVVLFPGHGIGPEISQAVCDIFAAA-------KVPIDWEHHEIYT 343 Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130 K G + E+L+ + Y+ +KGP TP+G G RSLNV +R++L+L+ +RP Sbjct: 344 --KPINEAGD--LIKEESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRP 399 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 R G +P + D+V REN+E Y+G+E E Sbjct: 400 CRSLAGVKTPYSN---VDLVTIRENTEGEYSGLEHAVVPGVVE----------------- 439 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 +K S+ + + R A E+A N+R V HK +MK +G F + +++ Sbjct: 440 ------NLKIISQPACENIARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKISS 493 Query: 251 E----EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 E E+ E ID KNP +DV+ NL G Sbjct: 494 EYPEIEYTEEQIDTVCMKLSKNPEV------------------------FDVMVMPNLYG 529 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 D +SD A +GG+G+ NI CA++EA HGTAP AG +K NP +++LS MML+ Sbjct: 530 DIVSDLCAGLIGGLGLTASGNISHTCAVYEAVHGTAPDIAGLNKANPTALLLSGVMMLKA 589 Query: 367 MGWTEAADLIV----------KGMEGAINAKTVTYDFERLMDG 399 MG + I K + G + K T D+ + + G Sbjct: 590 MGLQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIG 632 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 123/363 (33%), Positives = 181/363 (49%), Gaps = 66/363 (18%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY--TG 71 ++ N K N + +IP GDGIG +V A + V+D E + + IY G Sbjct: 1 MSTSNKKDNKYQIAVIP---GDGIGKEVMEATISVLD---------ELDVDFDYIYGIAG 48 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131 ++ + +G LP ET+D++R+ + G G + V +RQE+ ++ LRPV Sbjct: 49 DECNEEHG--TPLPQETIDIVRDSDACLFGA----AGETAADVIVKIRQEMKMFANLRPV 102 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + Y T S ++ D +I REN+E +Y AD E EE Sbjct: 103 KSYPNTKSLFEN---VDFMIVRENTEGLYI--------ADQE-------EET-------- 136 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E I + + E +R++ A +YA N+R VT VHK N++K T+G FK Y++ Sbjct: 137 EDGAIAKRVITREAEERIIDYAFQYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEV--- 193 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 GE K P+ E D DA ++ +P E+ V+ NL GD +SD Sbjct: 194 ---GE----------KYPDIDTE----DFYVDATAMYLVTQPQEFQVVVTTNLFGDILSD 236 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 A VGG+G+ P ANIG + ALFE HG+AP AGQ K NP +++LSA MMLR++G + Sbjct: 237 EGAGLVGGLGLIPSANIGADGALFEPVHGSAPDIAGQQKANPIAMMLSAIMMLRYLGEND 296 Query: 372 AAD 374 AAD Sbjct: 297 AAD 299 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 151 bits (382), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 122/391 (31%), Positives = 183/391 (46%), Gaps = 63/391 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG + + A+ ++ A E ++ ME K+ + G + E Sbjct: 23 VTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGME-----KNNKSSGDALH---EA 74 Query: 89 LDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G + +H + Sbjct: 75 IQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT--RHDNV- 131 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D I REN+E Y+G+E ++ E +K +E +K Sbjct: 132 DFAIIRENTEGEYSGLEHQSVPGVVES-----------------------LKIITEYKSK 168 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 169 RIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA------------------ 210 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 N I KD+I D Q + RP ++DV+ NL G +S+ +A VGG G+ PGAN Sbjct: 211 --NGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGAN 268 Query: 328 IGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-N 385 G + ALFE G+ + NP + ILSA +MLRH+G + ADLI I Sbjct: 269 FGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEE 328 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 KT+T D + G+ +F AI+E M Sbjct: 329 GKTLTKD----LGGSA--STGDFTHAILERM 353 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 150 bits (378), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 113/378 (29%), Positives = 169/378 (44%), Gaps = 71/378 (18%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 +GDGIG ++ A + ++A I W ++ G ++ Q G V++ +D Sbjct: 39 FDGDGIGREIVSAAKECIEAT-------GVNIRWEQMDMGYEAMQNTG--VYIDDSHMDA 89 Query: 92 IREYRVAIKGPLTTP----------VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 E V KGPLT P G S N R+ L+ +RPVR G +P Sbjct: 90 FEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVRAPF 149 Query: 142 KHPELTDMVIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 D+V+ REN+ED+Y G E W DA+ V HC +K Sbjct: 150 ND---VDLVVIRENTEDVYTGEETW----VDADTV-----------------HC---VKR 182 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ-LAREEFGGELID 259 S ++R+ + +YA N R VT +HK N+ K ++G F + ++ A + GG Sbjct: 183 ISRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGG---- 238 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL----AA 315 I+ D +AD+ L ++++ P +DV+ C NL GD ++ Sbjct: 239 ---------------IIADDQLADSCLTKLMIEPKSFDVLCCPNLYGDLVNPLSLRINRG 283 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VG +G+ P NIG ALFE HG+AP AG+ NP S ILS MML H+G EA+ Sbjct: 284 MVGSLGLCPSGNIGTHQALFEPAHGSAPDIAGKGIANPTSQILSGCMMLSHLGEFEASQR 343 Query: 376 IVKGMEGAINAKTVTYDF 393 + + + V DF Sbjct: 344 LENALRAMYASGIVPVDF 361 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 111/364 (30%), Positives = 174/364 (47%), Gaps = 46/364 (12%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P++ EG+ +G VT A+ + A I+W + G + Q LP Sbjct: 4 PVVLIQEGE-LGAQVTNALQMAIAAT-------GVDITWQIVDIGGED-----QQGLLPN 50 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 D+IR + A+ GPL P R + +R++LDLY+ LRP + G PS ++ Sbjct: 51 YIFDIIRTAKTAVIGPLMMP--DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNYQN--- 105 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I RE +E IYAGIE++ S +A FL + G K+IR E +GIKP S +G Sbjct: 106 VDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSG-KRIR--EDAAVGIKPISVKGC 162 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +++ A YA R V VH+ + M T+G F + +A+E Sbjct: 163 GQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQE--------------- 207 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I D + Q+++ +P +DV+ NL GD ++ A VGG+ + P A Sbjct: 208 -----FPDIAFADRSIEVICQELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIA 261 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 ++GD+ A+F A T G D P S+IL+ +MLRH+G EAA + +E + + Sbjct: 262 HVGDKYAVFGA-QSTGTDDVGHD---PTSLILAGALMLRHLGEQEAAQRLQAAVEAVVAS 317 Query: 387 KTVT 390 T Sbjct: 318 HVDT 321 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 148 bits (373), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 108/340 (31%), Positives = 160/340 (47%), Gaps = 56/340 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +++ + L +++A + + +I +E G+ + G+ LP ET Sbjct: 7 ISLVTGDGIGPEISESALSILEA-INDNFPLSLEIKKLE--AGDAVLKNTGK--ALPDET 61 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + I+ +K P VG + + V LR+ LDLY +RP + Y PS + D Sbjct: 62 FEAIKNSDACLKAP----VGESAKDVIVYLRRMLDLYANIRPAKSYPNMPS---LRDDVD 114 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN+ED+Y G E+ D DA + + SE+ +KR Sbjct: 115 LVIVRENTEDLYTGEEF--DIGDA----------------------AVAFRIISEKASKR 150 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + A A VT VHK N+MK T+G F ++A Sbjct: 151 IANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVA------------------- 191 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 N ++ +++ DA ++ +P +DVI NL GD +SD A VGG+G+AP ANI Sbjct: 192 -NDFPDVKFEEMYVDACAMNLIRQPQLFDVIVTTNLFGDILSDESAQVVGGLGMAPAANI 250 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 GD LFE HG A AG+ NP S ILS +MML +G Sbjct: 251 GDNFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLDWLG 290 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 148 bits (373), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 127/427 (29%), Positives = 198/427 (46%), Gaps = 84/427 (19%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAV-EKAYKGERKIS 64 V+ AQG + Q + II GDGIG +T ++++ + + +G+ + Sbjct: 26 VMKAQGDFLNYQ-----ALDKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFK 80 Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQ 120 ++ T E+ + +PAE L ++E V +KGP TTP G + S NVA+R+ Sbjct: 81 VIDGLTIERRA---AEHAAIPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRK 137 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFL 179 ELDL+ +RPVR PE D +REN+E YA Sbjct: 138 ELDLFANVRPVRI----------PEQGIDWTFYRENTEGAYA------------------ 169 Query: 180 REEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG 239 +G K I E G+ + G++R++RAA EYA AN + VT V K NI+K T+G Sbjct: 170 ---VGSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDG 226 Query: 240 AFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILL-------R 292 F D ++A++ KD+ AD + I+ R Sbjct: 227 KFLDIFREIAKD-------------------------YKDITADDWYIDIMTAKLIDEKR 261 Query: 293 PAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA--GQDK 350 ++ V+ NL GD I+D A GG+G A ANIG ++FEA HG+AP+ G+D+ Sbjct: 262 RKDFQVMVLPNLYGDIITDEAAEFQGGVGTAGSANIGKRYSMFEAIHGSAPRMVQEGRDQ 321 Query: 351 -VNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 +P S+I + M+L H+G+ + AD + + A++ TVT + +EF Sbjct: 322 YADPCSVIRAGAMLLAHIGYGKEADKLYQ----ALDICTVTEKKLVITGRNTGATGAEFA 377 Query: 410 DAIIENM 416 D I+E + Sbjct: 378 DYIMETI 384 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 146 bits (368), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 112/366 (30%), Positives = 171/366 (46%), Gaps = 62/366 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +V A + +++ K + + G+++ + YG+ LP ET Sbjct: 4 IVVIPGDGIGKEVMEAAMLILE-------KLDLPFEYSYYDAGDEALEKYGK--ALPDET 54 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L+ R+ + G G + V LR+EL + +RP + +G +P L D Sbjct: 55 LEACRKSDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECL--YPGL-D 107 Query: 149 MVIFRENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 +V+ REN+E +Y G E+ D +A +VI + E ++ Sbjct: 108 IVVVRENTECLYMGFEFGFGDVTEAIRVI-------------------------TREASE 142 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A E A R VT +HK N+MK T G F+D ++A++ Sbjct: 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY--------------- 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 EI D DA +++ P +DVI N+ GD +SD A VGG+G+AP AN Sbjct: 188 -----PEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G+ A+FE HG A AG+ NP ++IL+A MMLRH G+ E A + + +E I Sbjct: 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query: 388 TVTYDF 393 T D Sbjct: 303 KKTPDL 308 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 111/379 (29%), Positives = 179/379 (47%), Gaps = 68/379 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I ++G+GIG ++T A ++V++A + W I +++ ++YG LP + Sbjct: 3 IGVLKGNGIGPEITAATIRVIEATGIQP-------EWDFIPIADEAVRLYGHA--LPPQV 53 Query: 89 LDLIREYRVAIKGPL----------TTPVGGGI---RSLNVALRQELDLYICLRPVRYYQ 135 + I++ + IK PL T G + S+N A+R+EL+L++ RP+R Y Sbjct: 54 IQRIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYV 113 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G +H E DMVI RE +ED Y G E + A + IK + Sbjct: 114 GISG--RH-EKMDMVIMREITEDTYIGWEKPLEDGAAAEAIKRV---------------- 154 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 155 ------TRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVAR----- 203 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +IV D++ DA ++ P +DV+ +N GD SD A Sbjct: 204 ---------------LYPDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDIFSDLAAG 248 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 G +G+APGANIGD + FEA HG AP AG NP ++ILS +L H G+ + ++ Sbjct: 249 LAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHAGYGKGSEA 308 Query: 376 IVKGMEGAINA-KTVTYDF 393 I + + I A +T+T D Sbjct: 309 IREAVTRVIEAGRTLTPDL 327 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 143 bits (361), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 110/365 (30%), Positives = 164/365 (44%), Gaps = 59/365 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I IEGDGIG +V PA + V+ A E + S+ E G+ + G LP T Sbjct: 9 IVVIEGDGIGQEVIPAAVAVLQAVDEVGF------SFTEKQAGDDTRDQTG--AALPETT 60 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + + + G G + + LR+ + ++ +RP R Y G + PE TD Sbjct: 61 YEAAADADATLFGA----AGETAADVILPLREAVGSFVNIRPARAYPGVDA--LQPE-TD 113 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V REN+E +Y+G E R E + + +++ Sbjct: 114 LVFLRENTEGVYSGHED-----------------------RLSEDLSTLTRVITTSASEQ 150 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 L A Y D VHK N+M+ T+G F+D ++A Sbjct: 151 LAEYACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVA------------------- 191 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 ++ +V+ DAF ++ L P ++DV+ C NL GD +SD A VGG+G+ P ANI Sbjct: 192 --ASNDVATNEVLMDAFATRVCLNPTQFDVVVCPNLAGDVLSDLAAGLVGGLGLLPSANI 249 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G ALFE HGTAP AG NP + ILSA M+L ++G T+AA + +E +N+ Sbjct: 250 GQTNALFEPVHGTAPDIAGDGIANPSASILSAGMLLEYLGETDAATNVQMAVESVLNSGP 309 Query: 389 VTYDF 393 T D Sbjct: 310 RTPDL 314 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 142 bits (359), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 61/374 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAA----------VEKAYKGERKISWMEIYTGEKSTQVY 78 I I GDGIG +VT +KV++AA Y E +S ++ ++ Sbjct: 6 IGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGAEHYLSTRQVLPDHALEEME 65 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI--RSLNVALRQELDLYICLRPVRYYQG 136 G D L AI P P GI R + + LR D Y +RPVR + Sbjct: 66 GLDALLLG-----------AIGDPRVQP---GILERGILLKLRFHFDQYANIRPVRSF-- 109 Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSA-----DAEKVIKFLREEMGVKKIRFP 191 TP P+ + V+ REN+ED+Y GI D A + + ++ ++ P Sbjct: 110 TPGPLGS---VNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTP-P 165 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + + + + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 166 KRFAMQVAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQ 225 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 E + L+V+N DA +++ P ++ VI C N+ GD +SD Sbjct: 226 Y---ESVS----LRVEN-------------VDALCYKLVRSPGDFRVILCPNMFGDIVSD 265 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 LA GG+G+AP N+GD ++FE HG+AP AGQD+ NP + ILS M+LRH+G T Sbjct: 266 LLAGIGGGMGLAPSGNVGDRLSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS 325 Query: 372 AADLIVKGMEGAIN 385 AA K ME A+ Sbjct: 326 AA----KAMEDAVQ 335 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 137 bits (345), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 109/373 (29%), Positives = 181/373 (48%), Gaps = 61/373 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +V PA +V++ K +++++Y G ++ Q G+ LP ET Sbjct: 26 IGLIPGDGIGKEVIPAGKQVLE---NLNSKHGLSFNFIDLYAGFQTFQETGK--ALPDET 80 Query: 89 LDLIREY-RVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTP-SPVKHP 144 + +++E + A+ G + +P G S VALR+E+ L+ +RPV+ +G P+ Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEGEKGKPI--- 137 Query: 145 ELTDMVIFRENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 DMVI REN+ED+Y IE D A +V K SE Sbjct: 138 ---DMVIVRENTEDLYIKIEKTYIDKATGTRVAD-------------------ATKRISE 175 Query: 204 EGTKRLVRAAIEYAI----ANDRDSVTLVHKGNIMKFTEGAFKDWG---YQLAREEFGGE 256 T+R+ A++ A+ + ++T+ HK N++ ++G F++ Y+ ++++G Sbjct: 176 IATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYG-- 233 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 +I + I D+ + ++ P +DVI NL GD +SD AA Sbjct: 234 -----------------QIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAAL 276 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 VG +G+ P AN+G E + E HG+AP AG+ NP + I S +ML +G EAA I Sbjct: 277 VGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDI 336 Query: 377 VKGMEGAINAKTV 389 K ++ + ++ Sbjct: 337 YKAVDANLREGSI 349 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 135 bits (340), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 114/367 (31%), Positives = 165/367 (44%), Gaps = 73/367 (19%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 I GDGIG +V PA + V+ A + W + Q G+ LP+ TL Sbjct: 11 IPGDGIGREVIPAAVAVLRATGLPFHFENADAGW-------ECFQRQGE--ALPSATLTA 61 Query: 92 IREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL--T 147 R + G + +P G RS V LR+ELDLY +RPV + P +P Sbjct: 62 ARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRRRKV 119 Query: 148 DMVIFRENSEDIYAGIEWKAD---SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+YAG E D +A AE+VI + Sbjct: 120 DLVVVRENTEDVYAGRERVEDDGATAIAERVI-------------------------TRR 154 Query: 205 GTKRLVRAAIEYAIA-----NDRDS----VTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + R++R A + A A N D+ VT+VHK N+++ T G F+ ++A+ Sbjct: 155 ASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAY--- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ I +++ D Q+ RP +DVI NL GD +SD A Sbjct: 212 -----------------PDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACA 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 GG+G+AP AN+G+ ALFE HG AP AG+ NP + I ++L H+ ADL Sbjct: 255 WGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADL 314 Query: 376 IVKGMEG 382 M G Sbjct: 315 -ASAMRG 320 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 134 bits (338), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 105/351 (29%), Positives = 161/351 (45%), Gaps = 65/351 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I IEGDGIG +V PA V++A K ++E G ++ + G V P T Sbjct: 7 ICLIEGDGIGHEVIPAARLVLEAT-------GLKFEFVEAQAGWETFERIGTSV--PEAT 57 Query: 89 LDLIREYRVAIKGPLTTPVG------GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 L+ + + G T+P G IR +R++LDL+ +RP +++ P P Sbjct: 58 LEAVTHTDATLFGAATSPTKKVPGFFGAIRY----MRRKLDLFANVRPAKHH---PVPGS 110 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 P + D+++ REN+E +Y E+ +L E+ + + Sbjct: 111 RPGV-DLIVVRENTEGLY-----------VEQERSYLEGEIAIADTVI-----------T 147 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 + + R+ A A + R + + HK N++ T+G F + L + Sbjct: 148 RKASARIGEYAARLAASRPRKQLHVAHKANVLPMTQGLFMNT-----------VLAEAAR 196 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 + +VK +D+I D Q++ P +DVI NL GD ISD A VGG+GI Sbjct: 197 FPEVKT---------QDIIIDNCAMQLVRNPERFDVIVTTNLFGDIISDLTAGLVGGLGI 247 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 A NIG + A+FE HG+AP AG+ NP + ILS MML H+G EAA Sbjct: 248 AASGNIGIKHAVFEPVHGSAPDIAGKGIANPAATILSGVMMLDHLGEHEAA 298 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 134 bits (336), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 70/382 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK---ISWMEIYTGEKSTQVYGQDVWL 84 +I I DGIG +V PA ++V++AA+ K K ++ + ++ + G ++ Q G+ L Sbjct: 33 VIGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKS--L 90 Query: 85 PAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVR-YYQGTPSP 140 P ET++ ++ + AI G + +P G S VA+R+ +DLY +RP + +G Sbjct: 91 PVETVEALKNKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPCQDLAKGI--- 147 Query: 141 VKHPELTDMVIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 DM+I REN+E +Y E D EK + + Sbjct: 148 -------DMLIVRENTECLYIKKEKLTVDPTTGEKT-------------------AVADR 181 Query: 200 PCSEEGTKRLVRAAIEYAIANDRD---SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 +E +KR+ A + A+ +++ VT+VHK N++ ++G F++ ++++ Sbjct: 182 LITERASKRIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISK------ 235 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 K P E + + D+ + +++L P +YDV+ NL GD +SDA +A Sbjct: 236 ----------KYPQVKTE----EQLVDSMVYKMILDPTQYDVVVAPNLYGDILSDAGSAF 281 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------- 368 VGG+G+ AN+ D AL E HG+AP G+ NP + I + M+LRH+ Sbjct: 282 VGGLGVTASANLSDSFALVEPVHGSAPDIFGKKISNPIATIRACAMLLRHLQEKDPKCSY 341 Query: 369 WTEAADLIVKGMEGAINAKTVT 390 E AD + + + + KTVT Sbjct: 342 LNEIADSMDRAVNVVMPDKTVT 363 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 131 bits (330), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 103/362 (28%), Positives = 171/362 (47%), Gaps = 58/362 (16%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 IEGDGIG ++ PA +KV+DA + K ++ + T + D L+ Sbjct: 6 IEGDGIGREIIPAAVKVLDAFGLEFEKVPLELGYTR--WERTGTAISNND-------LET 56 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 151 I+ + G +TT +S+ + +R+ELDLY +RPV+ G + D +I Sbjct: 57 IKGCDAVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGVTGRNDF-DFII 115 Query: 152 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 211 REN+E +Y+GIE E+G PE + + +G++R+ Sbjct: 116 VRENTEGLYSGIE-----------------EIG------PELSWTK-RVVTRKGSERIAE 151 Query: 212 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNT 271 A + A ++ +T+VHK N++K ++ F D Q A + Sbjct: 152 YACKLA-KKRKNKLTIVHKSNVLK-SDKLFLDVCRQTA---------------------S 188 Query: 272 GKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE 331 + +D++ D+ +++RP YD++ NL GD +SD AA VG +G+ P ANIG++ Sbjct: 189 ANGVEYEDMLVDSMAYNLIMRPERYDIVVTTNLFGDILSDMCAALVGSLGLVPSANIGEK 248 Query: 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTY 391 A FE HG+AP AG+ NP + IL +M+L MG + +I + + + K +T Sbjct: 249 YAFFEPVHGSAPDIAGKGIANPLAAILCVKMLLEWMG-EPRSQIIDEAIAYVLQKKIITP 307 Query: 392 DF 393 D Sbjct: 308 DL 309 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 130 bits (326), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 114/393 (29%), Positives = 180/393 (45%), Gaps = 61/393 (15%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDGIG ++ PA +K++DAAV A I+W E+ G + YG+ P +TLD Sbjct: 29 LHGDGIGPEIVPASVKILDAAVAAAGA--TPIAWTELPLGRSAIDEYGEHT--PTKTLDA 84 Query: 92 IREYRVAIKGPLTTPV-GGGIRS-LNVA--LRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + E + GP + RS LN + +R+ L+ +RP + ++G + V E T Sbjct: 85 LDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNAIV---EGT 141 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+VI REN+E YA A G ++ I + T+ Sbjct: 142 DLVIVRENTEGFYADRNTFA----------------GTGEMMPTPDVAIMHGIITRAATE 185 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A + A D+ VT+VHK N++K T G F+D ++ ++ Sbjct: 186 RIAHEAFQLARTRDK-RVTIVHKANVLKMTTGLFRDVCREVGKQY--------------- 229 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 ++ I D DA ++ R ++DVI N+ GD +SD G +GIAP N Sbjct: 230 -----PDVAINDFHIDAATVHLVRRADKFDVIVTENMFGDILSDLAGEVAGSLGIAPSIN 284 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW-------TEAADLIVKGM 380 A+ +A+HG+AP AG+D NP ++ILS+ M+LR + AAD++ + Sbjct: 285 SSATHAMAQASHGSAPDIAGRDIANPIAMILSSAMLLRWLAAKFDDEKIARAADIVEAAV 344 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + + T D M G CS F DA++ Sbjct: 345 DLTVAEGATTPD----MGGTS--SCSGFADAVV 371 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 130 bits (326), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 110/391 (28%), Positives = 176/391 (45%), Gaps = 65/391 (16%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDG+G +V K +DA E I+W ++ G +G +PA+ +D+ Sbjct: 6 LPGDGVGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADAIDV 56 Query: 92 IREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPEL 146 +R + + G + P + L + +RQELDL++ +RP R +G P P+ + P Sbjct: 57 LRGHDAILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAPHD 116 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 DMV RENSE YAG+ +V + ++ ++ F + G Sbjct: 117 VDMVFVRENSEGEYAGV--------GGRVHRGFGHDVAIESSVF-----------TRRGC 157 Query: 207 KRLVRAAIEYAIANDRDSVTL-VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 +R++R A + +A+ R V + K N +F F W +A E G E Sbjct: 158 ERVIRYA--FGMASARKGVLVNATKSNASRF---GFPFWDEIVA--EVGAEF-------- 202 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 +V+ ++ DA +++ P DV+ NL GD ++D AA GG+G+A Sbjct: 203 -------PGVVVDRMLVDALSARLIRDPGSVDVVVASNLFGDILTDIAAALQGGMGMAAS 255 Query: 326 ANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 AN+ G ALFE HG+AP AG+ NP I SA +ML +G E + ++ +E Sbjct: 256 ANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSAALMLEQLGAGEGSRRLMDALE- 314 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 TV R D +E GDA++ Sbjct: 315 -----TVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 128 bits (321), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 117/405 (28%), Positives = 177/405 (43%), Gaps = 73/405 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ A ++V+DA E + R ++EI G + + G A+ Sbjct: 6 IGLIRGDGIGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTGV-ACAEADV 63 Query: 89 LDLIREYRVAIKGPL-----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L E +KGP+ TP G L LR LD Y +RPVR + G PS V+ Sbjct: 64 RRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRVR- 122 Query: 144 PELTDMVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + D VI REN+E +YA G W A + ++ Sbjct: 123 ADRVDYVIVRENTEGLYASRGKGVGNRW----AVTDTLL--------------------- 157 Query: 198 IKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + EGT R+ R A A A+ VT V K N+++ + F++ ++A Sbjct: 158 ---TTREGTLRVARKAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVA-A 212 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 EF E+ ++ ADA Q ++L P +DV+ N GD +SD Sbjct: 213 EF-------------------PEVELEYRYADAAAQDLVLCPERFDVLVMENFLGDVLSD 253 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 A VGG+G+ P N+GD A FE HG+AP G+++ NP +L+A M+L H+G + Sbjct: 254 LGGATVGGVGLCPAGNVGDGAAYFEPVHGSAPDLVGRNRANPVGQLLAAAMLLDHLGHVD 313 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + + + TV + DG L DA+I + Sbjct: 314 EAARLRRAVSAVLAFGTVRIE----ADGTVLGGAEAVADAVIAAL 354 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 128 bits (321), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 97/361 (26%), Positives = 156/361 (43%), Gaps = 65/361 (18%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 +++G G+G D + +V + + + E++ + +G+D LP T D Sbjct: 6 FVQGGGLGQDQ--------ELSVRRLFAAAKVPVEFEVHLAGRMALEHGKDA-LPKATFD 56 Query: 91 LIREYRVAIKGPLTTPVGGGI----------RSLNVALRQELDLYICLRPVRYYQGTPSP 140 IRE +A+K L P G G+ + NVA R++L L+ +RPV G PS Sbjct: 57 AIRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSR 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 D ++FRE +ED+Y E + + K Sbjct: 117 FTG---VDFLLFREITEDLYTASEHEIVPGVVQS-----------------------FKI 150 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +E R + A + A R +V +HK NI+K +G F + Y++A+E Sbjct: 151 VTEAACLRFFKLAFDTARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEY-------- 202 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 EI KD+I D Q++ RP +++V+A NL GD +SD A VGG+ Sbjct: 203 ------------PEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGAGLVGGV 250 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 N G+ ++EA +G + + D NP +IL A +L+ +G T A I K + Sbjct: 251 STTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETGTAGRIQKAV 310 Query: 381 E 381 E Sbjct: 311 E 311 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 127 bits (319), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 103/377 (27%), Positives = 179/377 (47%), Gaps = 37/377 (9%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 +P I GDGIG +V KV+ AA ++ Y + + W+++ G+ + + Sbjct: 6 VPVIAGDGIGPEVIAEGRKVI-AAAQEVYNFD--VEWIDMPFSADHYVKTGETI--SESS 60 Query: 89 LDLIREYRVAIKGPL--TTPVGGGI--RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 L + +YR G + V G+ + + + +R D Y+ LRPV+ +G +P+K Sbjct: 61 LKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGK 120 Query: 145 ELTDM--VIFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCGIGI 198 D+ + REN+ED Y GI ++ +++ ++ +R+ + G+ + + Sbjct: 121 TAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQL 180 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S+EG KR++ + + A + + ++ V K N++ Y RE F Sbjct: 181 GVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDI--------YGFWREVFTD--- 229 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 K P+ + D + F++ P +DV+ N+ GD I+D A G Sbjct: 230 -----TAAKYPDVKTDFNYVDAVTMWFVKN----PEFFDVVVSPNMFGDIITDLGAMIQG 280 Query: 319 GIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G+G+APG NI E ++FE G+APKY G +KVNP + I + M+L H+G +AA IV Sbjct: 281 GLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGEKQAAAGIV 340 Query: 378 KGMEGAINAKTV-TYDF 393 +E + K + TYD Sbjct: 341 DAIEQNLKEKKIRTYDL 357 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 127 bits (318), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 116/395 (29%), Positives = 174/395 (44%), Gaps = 73/395 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG P ML +V A + + E K T P Sbjct: 47 VTLLPGDGIG----PEMLDIVQKIFTFA---NVPVDFEECQLDSKPTS--------PESD 91 Query: 89 LD----LIREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTPS-PVK 142 LD I+ VAIKG + T I +S NV LR+ LDL+ V + P+ P + Sbjct: 92 LDNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLDLFA---NVLHCVSIPTIPTR 148 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 H + ++V+ REN+E Y+G E + + E +K C+ Sbjct: 149 HKGI-NIVMIRENTEGEYSGHEHETVNGVVE-----------------------SLKICT 184 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E +R+ R A +YAIA++R +T VHK NI K +G F ++A +E+ Sbjct: 185 REKLERISRFAFDYAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEY--------- 235 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 I +I D Q++ RP ++D++ NL G+ IS+ VGG G+ Sbjct: 236 ----------PSITFDSMIVDNASMQLVSRPQQFDIMLMPNLYGNIISNIACGLVGGPGL 285 Query: 323 APGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 G NIGD+ A+FE T T AGQD NP + I + ML ++G TE A+LI + Sbjct: 286 VSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTAFIRAGVDMLHYLGLTEYANLISDALF 345 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AI K + D K S+ +A++ N+ Sbjct: 346 DAIVIKRL-----HTKDIGGTAKTSDVVNAVMRNI 375 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 126 bits (317), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 111/392 (28%), Positives = 183/392 (46%), Gaps = 75/392 (19%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTP---AMLKVVDAAVEKAYKGERKISW-ME 67 K +T Q+ + +P GDGIGV+V M + ++ +++ Y + W ++ Sbjct: 5 KDVTFQHKIIVIP---------GDGIGVEVMSEAEKMFQSLNLPIQRDY-----VDWGIQ 50 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELD 123 Y K+ +V +P + +D +++Y + G P T P + L + +RQ+LD Sbjct: 51 HYL--KTGKV------VPIDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPL-IQMRQQLD 101 Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 ++CLRP +++ G P+P+K E+ D+++ RENSE Y+ I Sbjct: 102 QFLCLRPAKHFPGIPTPLKKCEI-DILVVRENSEGEYSNIG------------------- 141 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 G+ K P+ I + G +R++R A E A R+ VTL K N MK Sbjct: 142 GIFKSGTPDEFAIESAVHTRRGLERVIRYAFE-ASRKRRNHVTLATKSNAMK-------- 192 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 +G L F + ++ P+ E DA +I+ P+++DVI N Sbjct: 193 YGMVLWDSVFEA--------IAMEYPDVTAE----KYYMDALSAEIVKNPSKFDVIVGSN 240 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSA 360 L D ISD G +GIAP ANI E +LFE HG+A AG+ +P + ++ Sbjct: 241 LFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRAS 300 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYD 392 MML +G++E + LI + ++ +I K T D Sbjct: 301 SMMLEFLGYSEESVLIEEAIQSSILQKITTID 332 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 124 bits (312), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 106/368 (28%), Positives = 172/368 (46%), Gaps = 64/368 (17%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P I I GDG+G ++ A++ V++ + + + E G+++ + G V LP Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLET-LSDLMNLPLDLRFFE--AGDETKRKRG--VALPE 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ETL+ + L +G R + + LRQ+LDLY+ LRP + Y P P P Sbjct: 57 ETLNGVMNS----DATLMVAIGESAREVILPLRQKLDLYVNLRPAKSY---PVPRAIPGF 109 Query: 147 TDMVIFRENSEDIYAGIEWKA-DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ I REN+ED+Y W+ D+A + ++ + Sbjct: 110 -DLTIVRENTEDLYVMSGWRGLDTA-------------------------VDLRIITRRA 143 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 ++R+ R YA + V +VHK N++ F++ ++A EE G + Sbjct: 144 SERICRFGYRYARERGKSRVYVVHKANVLGGCM-LFREVCSRVAEEE-------GFDY-- 193 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILL-RPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +++ D+ +I + RP +DVI N+ GD +SD AA +GG+G+ P Sbjct: 194 ------------REMYVDSAAMRIAMDRP--FDVIITTNMFGDILSDLAAAFIGGLGMYP 239 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG+ A+FE HGTAP+ AG++ NP + ILSA MM+ +G + LI + + A Sbjct: 240 SANIGESRAIFEPVHGTAPEIAGKNIANPMATILSAAMMMGWLGHEGGSKLIEEAVRRAC 299 Query: 385 NAKTVTYD 392 T D Sbjct: 300 ELGYTTPD 307 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 124 bits (311), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 104/369 (28%), Positives = 169/369 (45%), Gaps = 60/369 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA-- 86 + I GDGIG ++ A+ + E +S ++I +D +L A Sbjct: 53 VTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKD---------EDSYLGAFN 103 Query: 87 ETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + G + +H Sbjct: 104 EAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT--RHN 161 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI R+N+E Y+ +E + S E +K +EE Sbjct: 162 NV-DLVIIRQNTEGEYSHLEHENVSGVIEN-----------------------LKVTTEE 197 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++ + A ++A +DR VT VHK NIMK +G F +++ Sbjct: 198 ACMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSY------------ 245 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 PN I +I D Q++ P ++DV+ NL G+ +S+ A+ VGG GI P Sbjct: 246 ----PN----IEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVSNIGASLVGGPGIVP 297 Query: 325 GANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 G NIG + A+FE+ + T G+D NP S++ ++ +ML H+ +T ADLI + Sbjct: 298 GENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLEHLEFTAYADLINSAILKV 357 Query: 384 INAKTVTYD 392 + +T D Sbjct: 358 VQRGVLTAD 366 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 124 bits (311), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 94/358 (26%), Positives = 169/358 (47%), Gaps = 60/358 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDG+G ++T ++ + +A I W I + + + V+ E+ Sbjct: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTD---HKEGVYEAVES 80 Query: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L + ++ +KG TP G SLNVALR++LD+Y + + +G + + P++ Sbjct: 81 L---KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--PDI- 134 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+++ REN+E ++G+E ++ E +K + T+ Sbjct: 135 DLIVIRENTEGEFSGLEHESVPGVVES-----------------------LKVMTRPKTE 171 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY-------------- 217 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I + +I D Q + +P ++DV+ ++ G + + AA +GG G+ GAN Sbjct: 218 -----PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 Query: 328 IGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + I Sbjct: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETI 330 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 123 bits (308), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 108/364 (29%), Positives = 156/364 (42%), Gaps = 65/364 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAV---------EKAYKGERKISWMEIYTGEK 73 +P + + GDGIG +V L+V+ AV + + + +I T Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPADVSLDTTQYPFGAGHFLETGQILTDSD 60 Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI--RSLNVALRQELDLYICLRPV 131 + D L R+ R+A GGI R L + LR D YI LRP Sbjct: 61 LAALAQHDAILLGAVGGDPRDARLA----------GGIIERGLLLKLRFAFDHYINLRPT 110 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 G SP+ P D V+ RE +E YAG GV + R Sbjct: 111 ALLPGVASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLR-RGT 150 Query: 192 EH-CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 EH + + G +R VR A E A DR VTLVHK N++ F A W + R Sbjct: 151 EHEIATEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTF---AGSLWQRTVDR 207 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + ++P ++ + + DA + ++ P+ +DVI NL GD I+ Sbjct: 208 -------------VAAEHP----DVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIIT 250 Query: 311 DALAAQVGGIGIAPGANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 D AA GGIG+A N+ G ++FE HG+AP AGQ K +P + ILS ++L H+ Sbjct: 251 DLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHL 310 Query: 368 GWTE 371 G +E Sbjct: 311 GLSE 314 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 123 bits (308), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 119/402 (29%), Positives = 175/402 (43%), Gaps = 70/402 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL---- 84 I I GDG G + LKV+ AA K E + E + +G + +L Sbjct: 19 IAVIPGDGTGPEQVREGLKVLHAAAGK-----------EGFALETTVLDWGGEYYLRTGE 67 Query: 85 --PAETLDLIREYRVAIKGPLTTP-VGGGI--RSLNVALRQELDLYICLRPVRYYQGTPS 139 P + ++ ++ Y G + P V GI + + + LR ELD YI LRPV+ Y G + Sbjct: 68 VLPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKLYPGVET 127 Query: 140 PV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ K PE D V+ REN+E +YAG G K P+ I Sbjct: 128 PIAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTPDEVAIQ 168 Query: 198 IKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + +G +R VR A EY R VTL K N++ F AF W + E G E Sbjct: 169 TSINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTF---AFDLW--ERVFNEVGEE 223 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVI-ADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 D + +D DA ++ P +DVI N+ GD I+D A Sbjct: 224 YPD----------------IERDYAHVDAICMWMVKNPEWFDVIVTDNMFGDIITDLGAM 267 Query: 316 QVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+GIA G N+ E ++FE G+APKY G++ +NP + + + MML +G T AA Sbjct: 268 LQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVINPLAAVCAGAMMLEQLGETGAAA 327 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + ++ K + L G E GD ++ ++ Sbjct: 328 RIEEAVK-----KVCAGHLKSLAAGRMGYGTDEVGDLVVSHL 364 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 122 bits (307), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 94/319 (29%), Positives = 155/319 (48%), Gaps = 52/319 (16%) Query: 97 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 156 A+KG T +G +S NV LR +LDLY + + Y P+ + D+++ REN+ Sbjct: 106 TALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSY---PTVITRHNNVDLIVIRENT 162 Query: 157 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 216 E Y +E + + VI+ IK +++ ++R+ + A +Y Sbjct: 163 EGEYTNLEHE----NIPGVIEM-------------------IKIITKKKSERIAKYAFDY 199 Query: 217 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIV 276 A+ N+R VT VHK NIMK ++G F + E+ +G P EI Sbjct: 200 AMENNRKKVTAVHKANIMKLSDGLFL---------KVCKEVAEGYP-----------EID 239 Query: 277 IKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE 336 D+I D Q++ +P ++DVI NL G+ +S+ AA VGG G+ G N G+ +FE Sbjct: 240 FNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAALVGGPGLPHGENHGNGIHVFE 299 Query: 337 A-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFER 395 + T + A ++ NP S++ +A +LRH+ ++ A LI E I+ K VT + R Sbjct: 300 SGTRNSGMDIATKNIANPMSMLFAATALLRHLQLSKHAQLI----ESCIH-KIVTTNQAR 354 Query: 396 LMDGAKLLKCSEFGDAIIE 414 +D SEF + +++ Sbjct: 355 TVDIGGNTSTSEFFEILVK 373 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 121 bits (303), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 90/289 (31%), Positives = 131/289 (45%), Gaps = 49/289 (16%) Query: 112 RSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPELTDMVIFRENSEDIYAGIEWKADS 169 R + +R DLY +RPVR P+K + D V+FREN+E IY G+ Sbjct: 91 RDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFRENTEGIYVGMG----- 145 Query: 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVH 229 G K P+ I + +G +R++RAA +YA AN R VT+ Sbjct: 146 --------------GQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMAD 191 Query: 230 KGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGK--EIVIKDVIADAFLQ 287 K N M+ EL WL+V + + EI V DA Sbjct: 192 KSNAMRHAH-----------------EL-----WLRVFHEVRAQYPEIQSNHVYVDALCL 229 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD----ECALFEATHGTAP 343 ++ P ++ VI NL GD ++D AA GG+G+A AN+ ALFE HG+AP Sbjct: 230 YVIQDPGQFQVIVTNNLFGDIVTDLGAALQGGLGMAASANVHASDPARVALFEPVHGSAP 289 Query: 344 KYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYD 392 AG+D NP + +L+A ++L H+GW E I + + A++ T D Sbjct: 290 PLAGKDIANPFAAMLTAGLLLAHLGWPEEERRIERWVSQALDQGMCTVD 338 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 120 bits (301), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 105/370 (28%), Positives = 164/370 (44%), Gaps = 68/370 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V+ A ++V+ A+ ++ I + + G + + G P T Sbjct: 15 IAVVPGDGIGPEVSAATVRVLTQALGTSFP----IEFRDYDAGAECFRRTG--TAFPEAT 68 Query: 89 LDLIREYRVAIKG---------PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 R+ + G P T G + ++ +R LDLY +RP+R +G P Sbjct: 69 QVACRQAHAVLHGAAGLPDVLFPDGTEAG---QDFSMKIRAALDLYANVRPIRLMEGAPR 125 Query: 140 PV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + K P+ I REN+E +YA A +R ++ + Sbjct: 126 RLVGKGPDDIRFTIVRENTEGLYA----------ARGGGNIIRGQIATDTLVM------- 168 Query: 198 IKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + EG +R+VR A E A A+ VT+V K N+++ Y RE Sbjct: 169 ----TREGVERIVRYAAELARDGQGAPADGVRRVTIVDKANVLR---------SYAFFRE 215 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 G L D P ++V++ VI DA ++ RP +DVI C NL GD +SD Sbjct: 216 IADGVLADC-PGIEVEH-----------VIVDAMTVHMIERPEHFDVIVCENLFGDILSD 263 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 AA +GG+G+AP IG + F+ +HG+AP AG+ NP + ILS MML +G Sbjct: 264 LGAAIMGGMGLAPSGEIGRDHGYFQGSHGSAPTIAGKGLANPIACILSGAMMLDWLGKRH 323 Query: 372 AADLIVKGME 381 + + + E Sbjct: 324 SDPALTRAAE 333 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 119 bits (299), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 120/419 (28%), Positives = 187/419 (44%), Gaps = 72/419 (17%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEK 73 +T++N L I + GDGIG +V PA L++V+AA A G +++ T Sbjct: 1 MTMKNDTLT------IAVLPGDGIGREVMPACLELVNAATTMA--GAPALAFQ---THNA 49 Query: 74 STQVYGQD-VWLPAETLDLIREYRVAIKGPLTTP---VGGGIRSL-NVALRQELDLYICL 128 Q Y + LPA TLD R+ + G + P G + + LR EL L+ + Sbjct: 50 GAQYYAESGDALPASTLDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGV 109 Query: 129 RPVRYYQGTPSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 RP+R++ G P + P E D V+ RE +E ++ + R G Sbjct: 110 RPIRWFPGLPRVLTDPRAEQIDFVLVREQTEGLF-----------------YAR---GRG 149 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFK 242 +IR E ++ + GT+R+ A + A R +VT V K N+ F AF Sbjct: 150 EIRNDEEAYDTMQ-ITRSGTQRVTEFAFDIARQRKRRGKPGNVTCVDKANV--FQSMAF- 205 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKD-VIADAFLQQILLRPAEYDVIAC 301 ++ +E D + KD DA ++ +P +DV+ Sbjct: 206 ---FRKVFDEVADRHSD----------------LTKDHAYVDALALNMVKKPWTFDVLVT 246 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 N+ GD +SD A +GG+G+AP A+IGD+ LF+ HGTAP AG+ NP ++ LSA Sbjct: 247 ENMFGDILSDLAAGLIGGMGMAPSADIGDKHGLFQPAHGTAPDIAGKGCANPSAMFLSAA 306 Query: 362 MML----RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MML G AD + MEGA+ T++ M+ C+E ++I ++ Sbjct: 307 MMLDWLAAKFGQPTLAD-AARLMEGAVE-HTLSTKLAIPMEYGGNANCAEMTRSVISSL 363 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 119 bits (299), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 110/403 (27%), Positives = 179/403 (44%), Gaps = 59/403 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG++V A L V+ A I W + + E T +PA T Sbjct: 10 ICVLPGDGIGIEVMEAALPVIAALNLPFDLVPADIGW-QCWRAEGET--------VPART 60 Query: 89 LDLIREYRVAIKGPLT-------------TPVGGGIRSLN--VALRQELDLYICLRPVRY 133 +++ + G +T T G R ++ + LRQ LDLY +RPV Sbjct: 61 WEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTD 120 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR-FPE 192 G V+ REN+E +YAG+++ DA + RE +G R + Sbjct: 121 MTGE-------NRFRFVVIRENTEGLYAGLDFGC-IPDALVPLLEEREALGAAWQREGQD 172 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++ + G R+ A EYA N VT V K +++ + AF ++ + Sbjct: 173 DATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSS-AFARGIFEATAQR 231 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + P+ VI++V DA ++ RP + VI N+ GD +SD Sbjct: 232 Y---------------PDVSG--VIENV--DAVALWMVQRPERFGVIVAENMFGDILSDL 272 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 A +GG+G AP N G+ A FE HG+AP +AG +K NPG++ ++ +ML H+G+ Sbjct: 273 GAGVMGGLGFAPSGNFGNSGAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFPTE 332 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + I + + T TYD + G+ ++ G+AI++ Sbjct: 333 SACISQAVSLVSRTSTRTYD----LGGSH--TTAQVGEAIVQQ 369 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 118 bits (295), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 103/355 (29%), Positives = 160/355 (45%), Gaps = 59/355 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +V A + + AA+E G R + GE+ + Q +P + Sbjct: 10 LAVIPGDGIGPEVVAATVPALRAALEA--DGHRLDVTSFDWGGERYLR---QGAAMPPDA 64 Query: 89 LDLIREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 DL+++ + G + P + L + LRQ+LDL + LRPVR + G P+ V+ + Sbjct: 65 ADLVKKTDAVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDTD 124 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI REN+E Y G GV GI + S Sbjct: 125 GVDLVIVRENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRRA 165 Query: 206 TKRLVRAAIEYAIANDRDS-VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R A +A+A R + LV K N M++ GY L W Sbjct: 166 IERAAHQA--FALAGRRSGRLCLVTKSNAMRY--------GYPL--------------WD 201 Query: 265 KVKNPNTGKE---IVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 +V G++ + ++ V+ DA +++ P DV+ NL GD +SD A GG+G Sbjct: 202 RVVR-EVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLASNLFGDILSDLAAVLAGGMG 260 Query: 322 IAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 +AP AN+ + ++E HG+AP AG+ NP + +LS M+L +G T+AA Sbjct: 261 MAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLLSGAMLLEDLGHTDAA 315 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 118 bits (295), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 106/353 (30%), Positives = 145/353 (41%), Gaps = 64/353 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY--TGEKSTQVYGQDVWLPA 86 I I GDGIG +V L V+DA + Y TGE T G D Sbjct: 22 IAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALT---GSD----- 73 Query: 87 ETLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 LD IR A+ G + P G +R + LR ELDLY+ RP R + SP++ Sbjct: 74 --LDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRD 131 Query: 144 P--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 P D VI REN+E +Y+GI G + PE + + Sbjct: 132 PARRAIDCVIVRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLS 172 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD-WGYQLAREEFGGELIDG 260 + G R+ +E+A + R SV LV K N ++ ++ WG +AR Sbjct: 173 TRHGVSRV----LEFAFSAARRSVCLVDKANAVRNGGQLWQRCWGEAVARH--------- 219 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I + D ++ P +DVI N GD +SD AA GG+ Sbjct: 220 ------------PHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDILSDLTAALAGGL 267 Query: 321 GIAPGANIGDEC--ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 G+A AN+ ALFE HG+AP AG NP ILS ++ H+G E Sbjct: 268 GVAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAEHLGRNE 320 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 117 bits (294), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 150/337 (44%), Gaps = 61/337 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I+GDG+G ++ A L +++ Y G ++EI G+ G+ + Sbjct: 3 IAVIKGDGVGPEIMGATLSLLER-----YIGA---DFIEIKAGKSYFIEEGKPI--EDNA 52 Query: 89 LDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 ++ IRE +KGP+ TP G S+N LR+E LY +RP R Y+G Sbjct: 53 IEKIRECDSLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGI-----SIRRI 107 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D ++ REN E +Y G W+ + D I ++ ++ G + Sbjct: 108 DTILVRENLECLYYG--WEVEDEDR----------------------AIAMRVITKRGAE 143 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A A R VT +HK NI+K T+G F D Y++A Sbjct: 144 RISEFAFNLAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVA------------------ 185 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + ++ D I DA +++ +DV+ NL GD +SD A VG IG+ A Sbjct: 186 ---SKFDLRADDEIVDAAGYKLVKLDNAFDVMLTPNLYGDILSDVAAGVVGSIGLCGSAQ 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 IG++ A FE HGT AG+ NP +I++A MML Sbjct: 243 IGEDFAAFEPIHGTGEDIAGKGVANPIGMIIAASMML 279 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 117 bits (292), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 106/346 (30%), Positives = 153/346 (44%), Gaps = 52/346 (15%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 I GDGIG +V LKV+ A A + + E G + G+ LP + Sbjct: 11 IPGDGIGPEVVAEGLKVLSAV---APRHGLTLDTTEYELGAQRWHATGE--VLPDAVEEE 65 Query: 92 IREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPEL 146 +R++ + G + T P G R L + LR Y+ LRPVR Y G +P+ PE Sbjct: 66 LRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVAPED 125 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 DM++ RE +E YAG+ GV + P + G Sbjct: 126 IDMLVVREGTEGPYAGMG-------------------GVLRKGTPHEIATQDSVNTRLGV 166 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+VR A A +TLVHK N++ + A + W Q E G E Sbjct: 167 ERVVRYAFAKAAERPCHKLTLVHKDNVLTY---AGELW--QRVVREVGAEY--------- 212 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ + + DA + +P +DV+ NL GD I+D AA GGIG+A Sbjct: 213 ------PQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGGIGLAASG 266 Query: 327 NI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 NI GD ++FE HG+AP AGQ K +P + ILS +ML H+G+ Sbjct: 267 NINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGY 312 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 107/391 (27%), Positives = 181/391 (46%), Gaps = 50/391 (12%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI--YTGEKSTQVYGQDVWLPAETL 89 +EGDGIG ++ A + V+ AA+ K Y + + + EI + +K + +V AE Sbjct: 9 LEGDGIGPEIAKASVDVLQAAL-KLYDLKVNLVYEEIGFASLKKHKTTFRSEVLKIAEKC 67 Query: 90 D-LIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 D +I P T GG+ V +R+ DLY +RP + G + P D Sbjct: 68 DGMILGTCSHNDYPPTEE--GGLNPSGV-IRKYFDLYANVRPAKNRLGKLE--RFPMGID 122 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 ++ REN+E Y+ + K GV ++ I I+ + +G+ R Sbjct: 123 CLVMRENTEGFYSD----------RNMFK------GVGELMPTPDVAISIRNITRKGSTR 166 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + +YA+ R + +HK N++++++G F + Q+++ K Sbjct: 167 IAEIGFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSK----------------KY 209 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 P E+ K+ I D+ ++ P+ +DVI NL GD +SDA + GG+G+A N Sbjct: 210 P----EVEYKEQIVDSMSAMLIRDPSVFDVILATNLFGDNLSDAASEIAGGLGLAESINA 265 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW---TEAADLIVKGMEGAIN 385 G+ + +A HG+AP AG++ NP S+I S MML +G + I + +E AI+ Sbjct: 266 GENYCIAQAQHGSAPDIAGKNIANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAID 325 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 KT+ R D L ++F D +I N+ Sbjct: 326 -KTIINPKTRTSDIGGNLSTTDFTDVLISNL 355 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 113/395 (28%), Positives = 174/395 (44%), Gaps = 71/395 (17%) Query: 34 GDGIGVDVTPAMLKVVDAAV-EKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI 92 GDGIG + L+V + ++ G+ + + T E+ Q ++ LPAE L+ Sbjct: 54 GDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQ---KNESLPAEVLEAC 110 Query: 93 REYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-T 147 + V +KGP TP G + S N LR+ L LY +RPVR PE Sbjct: 111 KACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRI----------PEKGI 160 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D FREN E Y W G K I+ + + K + G + Sbjct: 161 DWTFFRENIEGEYI---W------------------GNKGIQVDDDLAVDFKVLTRPGAE 199 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ RAA E+A N + +VT+V K NI+K +G F + L +E P + V+ Sbjct: 200 RICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEY---------PGITVR 250 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +E+V D +A Q + + V NL GD ++D A GG+G A +N Sbjct: 251 -----EELV--DSMAAKITDQEFTKGMQ--VFLLPNLYGDIVTDVAAEYQGGLGTASSSN 301 Query: 328 IGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 IGD+ ALFEA HG ++ +P S+I + M+ H+G+ E + +VK ++ Sbjct: 302 IGDQYALFEAIHGVGNFLVQHNRAQYADPCSLIRAMGEMISHIGYPEKKEQLVKALDICT 361 Query: 385 NAK---TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +T D DGA EF D +++ + Sbjct: 362 RTERKVVITTD----KDGA---TAEEFTDYLLDTL 389 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 116 bits (291), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 105/344 (30%), Positives = 152/344 (44%), Gaps = 72/344 (20%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +V ++V+ KA G + + E G Q G + E Sbjct: 4 VAVIPGDGIGPEVIDGAVRVL-----KAVTGRVRFEYYE--GGVDVFQECGSPIR--EED 54 Query: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL- 146 L+ IR + G TTP G RSL + LR+EL LY LR + P+L Sbjct: 55 LEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLRII------------PDLR 102 Query: 147 --TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 ++VI RENSE +Y GI + + ++ + E Sbjct: 103 TGREIVIVRENSEGLYFGIGAVVNGR------------------------AVDVRLITRE 138 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G +R+ R A+E A A +T VHK N++ + F+ ++ RE G E ++ Sbjct: 139 GAERIARFAVEQAKARG-SFITFVHKANVLT-GDKFFR----RIVREVAGEEGVE----- 187 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++D I D+F +++ P E+ VI NL GD +SD G IGI P Sbjct: 188 ------------VRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVP 235 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 N GD ALFE HG+AP AG+ NP ILS M+L ++G Sbjct: 236 SGNYGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLG 279 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 116 bits (290), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 114/384 (29%), Positives = 171/384 (44%), Gaps = 71/384 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD-VWLPAE 87 + I GDGIG ++ P V AA+ IS + T + S++ Y + + + + Sbjct: 4 VALIPGDGIGREIMPG----VAAAISS-------ISDINFVTFDISSERYIKTGIIIKDD 52 Query: 88 TLDLIREYRVAIKGPLTTP-VGGGIRSLNVALR--QELDLYICLRPVRYYQGTPSPVKHP 144 L+ ++ YR + G + P V GI V LR +EL+LY+ +RPVR + Sbjct: 53 ELEELKNYRAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD--------- 103 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + + I REN++D Y D +I R V R I C E Sbjct: 104 DKIKITILRENTQDFYT---------DISGIIPGKRS-FNVNGTRIE----IDGSSCDEV 149 Query: 205 G------TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 + R ++ A + +VT+ K N +K Y L R I Sbjct: 150 YYTMGMLSYRYLKKFFNKAFSICDSTVTVTDKANAVKM---------YNLWRSTAMEAAI 200 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 + KN N E ADA ++L P +Y I NL GD ISD AA VG Sbjct: 201 E-------KNINISFEY------ADALAYNMILNPKKYRYIIAPNLYGDIISDMGAALVG 247 Query: 319 GIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI-- 376 G+G AP ANIGD+ ALFE HG+AP AG+D NP + I++ M+L ++G+ + + +I Sbjct: 248 GLGYAPSANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYLGYRDESRIIND 307 Query: 377 -VKGM--EGAINAKTVTYDFERLM 397 V+ + G N++ + ER M Sbjct: 308 MVRNLYINGVFNSERTSKIIERFM 331 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 101/389 (25%), Positives = 167/389 (42%), Gaps = 67/389 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G P +L V + I + E+ ++S D L Sbjct: 71 VAMLLGDGVG----PELLSYVKEVFQVI---GAPIDFEEVAVNQESEDATFTDALLA--- 120 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 ++ V IKG T G R NVALR L+LY ++ R + P V + D Sbjct: 121 ---MKRNGVGIKGNFATEPGQSSR--NVALRLNLNLYAFVQRCRNF---PGVVTRHQNVD 172 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN+E Y+ +E + E +K + E + R Sbjct: 173 IVIIRENTEGEYSRLEHENVPGVVES-----------------------LKIITREKSTR 209 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + + A +YA+ ++R VT VHK NIMK +G F D +A+ Sbjct: 210 IAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY---------------- 253 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I +I D Q++ +P ++DVI NL G+ + + A VGG G+ G N+ Sbjct: 254 ----PQIEFNHMIIDNTCMQLVTKPQQFDVIVLPNLYGNIVGNVAAGLVGGAGLTTGINL 309 Query: 329 GDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 G + ALFE T + AG++ NP ++L++ ML ++G + A LI + I + Sbjct: 310 GPQNALFEMGTRNSGRSLAGKNIANPCGMLLTSADMLEYLGHIKEAKLIRDSVVDVIGEQ 369 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + R D K S+ +A+++++ Sbjct: 370 KI-----RTADLGGSFKTSKVIEAVLKSL 393 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 115 bits (289), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 96/343 (27%), Positives = 156/343 (45%), Gaps = 48/343 (13%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP--- 85 I + GD IG ++ P ++V+ AA A + I W +I G + G LP Sbjct: 3 IGILNGDDIGHEIVPEAVRVMQAA---AARTGLAIEWQDIPIGRAALDSLGST--LPDGT 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E LD + + + G + P + + LR+ DL+ +RPV+ + P H + Sbjct: 58 IERLDALDGWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPC--LH-Q 114 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI REN+E ++ D V+ G + R I ++ + G Sbjct: 115 GVDLVIVRENNEG------FQPD----RNVVA------GSGEFRPTPDVTISVRVITRNG 158 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + ++ RAA E A A R +T VHK + K G F + +LA E Sbjct: 159 SSKVARAAFELARARRR-HLTAVHKDTVFKLGCGMFAEECRRLAAEY------------- 204 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 ++ + I D F ++++ P YDV+ N+ GD ++D A VGG+G+A G Sbjct: 205 -------PDVTYDEAIVDTFAMRLVMTPQRYDVVVTTNMFGDILTDEAAGLVGGLGMAAG 257 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 G A+ +ATHG+AP AG+ NP ++I+S +M+L +G Sbjct: 258 LCAGPRHAMAQATHGSAPDIAGRGIANPYAMIMSGQMLLDWLG 300 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 114 bits (286), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 102/360 (28%), Positives = 155/360 (43%), Gaps = 52/360 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDG+G +V A KV+ A E G S+ +G+ +P + Sbjct: 8 IAAIPGDGVGKEVVAAAEKVLHTAAE--VHGGLSFSFTAFPWSCDYYLEHGK--MMPEDG 63 Query: 89 LDLIREYRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + ++ A+ P P + L + +R+EL+L I +RP + G SP+ HP Sbjct: 64 IHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHP 123 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D V+ RENSE Y+ + + D +E+ ++ F + + Sbjct: 124 NDFDFVVIRENSEGEYSEVGGRIHRGD---------DEIAIQNAVF-----------TRK 163 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 T+R++R A E A R VT K N + + F D +Q ++ G Sbjct: 164 ATERVMRFAFELA-KKRRSHVTSATKSNGI-YHAMPFWDEVFQQTAADYSG--------- 212 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 I DA + RP +DVI NL GD ++D ++ +G IGIAP Sbjct: 213 ----------IETSSQHIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAP 262 Query: 325 GANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 ANI G ++FE HG+AP AGQ NP I +A++ML H G E I+ ME Sbjct: 263 SANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVME 322 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 114 bits (286), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 105/363 (28%), Positives = 159/363 (43%), Gaps = 56/363 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEK-AYKGERKISWMEIYTGEKSTQVY-GQDVWLPA 86 I I GDGIG +V P ++V++AA K +K + T + S Y Q +P+ Sbjct: 9 IAVIPGDGIGNEVVPEGIRVLEAASAKFGFK-------LAFTTYDWSCARYHSQGSMMPS 61 Query: 87 ETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV-- 141 + ++ +R+ G + P + +L + +R+E D Y+ LRPVR G P P+ Sbjct: 62 DGIERLRDSDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLAN 121 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 K P D I REN+E Y+ + ++ E ++ F Sbjct: 122 KKPGDIDFWIVRENTEGEYSQV--------GGRMFAGTEHEFVTQEAIF----------- 162 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + GT R++R A + A R+ VT K N + F F D + E+ Sbjct: 163 TRRGTDRIMRYAFDLAKKLGRNHVTSATKSNGI-FHSMPFWDERFAAVGAEY-------- 213 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 P+ + D++A F + P +DV+ NL GD +SD G I Sbjct: 214 -------PDIRTDQYHIDILAARFA----MSPERFDVVVGSNLFGDILSDLGPGITGTIA 262 Query: 322 IAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 +AP ANI E ++FE HG+AP AGQ NP I S MML H+G EAA I++ Sbjct: 263 VAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIWSGAMMLEHLGQPEAAAAIMQ 322 Query: 379 GME 381 +E Sbjct: 323 AIE 325 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 114 bits (285), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 105/360 (29%), Positives = 166/360 (46%), Gaps = 50/360 (13%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V LKV+ +K Y + M ++ E Q +G+ +P Sbjct: 6 IAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHAD-MFLWNSEYYLQ-HGR--MMPENG 61 Query: 89 LDLIREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 LD+++ Y + G + P + L + +R+ Y+ LRPV+ +G P H E Sbjct: 62 LDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQE 121 Query: 146 L-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + VI REN+E Y S ++ + +E+ V+ + + Sbjct: 122 RPINFVIVRENAEGEY--------SNSGGRIYQGTDQEIAVQN-----------TIITRK 162 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 GT+R+ R A +YA + V K N + + K W E+I+ + Sbjct: 163 GTERIARYAFQYAKKHGYQKVINATKSNAVVHS---MKLWD----------EVIEH---V 206 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + P+ E D +A F+Q RP VI NL GD +SD +A VGG+GI+P Sbjct: 207 ASEYPDIQLEKYYIDALAAYFVQ----RPDTLQVIVASNLFGDILSDLGSALVGGLGISP 262 Query: 325 GANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 ANI E ++FE HG+AP AG+ K NP + I SA +ML+ +G + A +I+K +E Sbjct: 263 SANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIILKAIE 322 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 114 bits (284), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 102/390 (26%), Positives = 181/390 (46%), Gaps = 60/390 (15%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 IEGDGIG +V +K +++ + + + S+ + G K+ + +G +P ET+D Sbjct: 8 IEGDGIGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MPKETIDS 62 Query: 92 IREYRVAIKGPLTTP----VGGGIRSLN--VALRQELDLYICLRPVRYYQG-TPSPVKHP 144 + + G + P G+R + + LR+E+DLY +RP+ Y G SP+K Sbjct: 63 CLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPIKER 122 Query: 145 EL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 +L + VI+RE + IY G K S + ++ ++C S Sbjct: 123 KLEGVNFVIYRELTGGIYFG--KKGRSKNGKEAY---------------DYCVY-----S 160 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ +R+ + + A + +R +TLV K N+++ + +L RE +D Sbjct: 161 EKEIERIGEMSFKAARSRNR-KMTLVDKANVLETS---------RLWREVIQKMALDYS- 209 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ ++ + D QIL+ P ++DVI N+ GD +SD + +G+ Sbjct: 210 -----------DVDLEFLYIDNAAMQILINPRKFDVILTDNMFGDILSDEASILTSSLGL 258 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 P A+IG + +LFE HG+ P+ G++ NP ILS MML + + +L+ + ++ Sbjct: 259 LPSASIGSKKSLFEPIHGSYPQAKGKNIANPLGCILSVSMMLEYFEMPQEKNLLEEAVKS 318 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 +I K T D ++D E GD I Sbjct: 319 SIQEKICTPDI--ILDDRNSSSTEEVGDYI 346 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 114 bits (284), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 107/368 (29%), Positives = 161/368 (43%), Gaps = 50/368 (13%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ P + +V + IS S + + + + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTFYNIS---------SERYINKGITIKDSE 54 Query: 89 LDLIREYRVAIKGPL-TTPVGGGIRSLNVALR--QELDLYICLRPVRYYQGTPSPVKHPE 145 +D ++ Y G + V GI V LR +ELDLY+ +RP + H Sbjct: 55 IDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITGNNIH-- 112 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIK----FLREEMGVKKIRFPEHCGIGIKPC 201 M I REN ED Y+ I + S + K+ + F + + + + Sbjct: 113 ---MTILRENKEDFYSDI---SGSLNEHKLFRQKGNFYNYNIDINS-ESDDTIYYTMGFL 165 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S + KR A Y IA D ++VT+ K N + Y L RE Sbjct: 166 SRKNLKRFFNMA--YKIA-DTETVTITDKANAVDM---------YSLWRE---------- 203 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++ P GK+I + AD+ ++ P +Y I NL GD +SD +A VGG+G Sbjct: 204 IAIEESEP-AGKKINFE--YADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLG 260 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 AP NIGD ++FE HG+AP AG++ NP + ILS MML+H+ TE A ++ K +E Sbjct: 261 YAPSGNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVE 320 Query: 382 GAINAKTV 389 I T+ Sbjct: 321 NVIRNGTI 328 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 113 bits (283), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 103/384 (26%), Positives = 169/384 (44%), Gaps = 61/384 (15%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 PA+ K TL K + + + G GIG P M++ V+A G+ + + Sbjct: 30 PARCSKRTLHR-KSKIGGRFFVTLLPGHGIG----PEMMRHVEAIFAC---GKVPVDFET 81 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPL-TTPVGGGIRSLNVALRQELDLYI 126 I D + IR VA+KG + TT + N+ LR +L+LY+ Sbjct: 82 IIVDANVGDASSMD-----HAIKSIRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYV 136 Query: 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 + R + G + KH + D+V+ R+N+E Y+ +E + S V++ L+ K Sbjct: 137 NVVHCRNHPGINT--KHKGV-DIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAK 189 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 + ++C EYA + R VT+VHK NIMK T+G F Sbjct: 190 SFQIAKYC-------------------FEYARTHMRKKVTVVHKANIMKLTDGLFLKTCT 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++A+E +I + D+I D Q++ PA++DV+ NL G Sbjct: 231 EVAQEY--------------------PDIELNDIIIDNCCMQLVANPAQFDVMLVPNLYG 270 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + + + VGG G+ G N G E A+FE AT T G++ NP + + +A ML+ Sbjct: 271 NIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVATLYAAVDMLK 330 Query: 366 HMGWTEAADLIVKGMEGAINAKTV 389 H+ + A +I + +E +N V Sbjct: 331 HLELWDHAVVIRRAIEKTVNRDKV 354 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 113 bits (282), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 105/351 (29%), Positives = 149/351 (42%), Gaps = 60/351 (17%) Query: 32 IEGDGIGVDVTPAMLKVVDAA---VEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG +V LKV+ A VE W TGE LP Sbjct: 6 IPGDGIGPEVVAEGLKVLRAVAPDVESTPYDLGASRWQR--TGE----------LLPDTV 53 Query: 89 LDLIREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 LD +R + + G + + P G R L + LR ELD ++ LRP R + G SP+ P Sbjct: 54 LDELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAPG 113 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 DM+ RE +E Y G GV + P + + G Sbjct: 114 AIDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAFG 154 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 +R+VR A E A+A R +TL+HK N++ A W + EE E Sbjct: 155 VERVVRYAFERALARPRRHLTLIHKTNVLTH---AGSLWSRTV--EEVSAEF-------- 201 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 E+ + DA + P +DVI NL GD ++D AA GGIG+A Sbjct: 202 -------PEVTVAYQHVDAASMFFVTDPGRFDVIVTDNLFGDIVTDLAAAVTGGIGLAAS 254 Query: 326 ANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 N+ G ++FE HG+AP AG+ +P + +LS ++L H+G + A Sbjct: 255 GNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSVGLLLDHLGRADQA 305 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 113 bits (282), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 88/323 (27%), Positives = 160/323 (49%), Gaps = 55/323 (17%) Query: 97 VAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 155 + +KG +TT + +S+N +R++LDLY + P + G + +H ++ D+V+ REN Sbjct: 142 IGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT--RHGQV-DLVVIREN 198 Query: 156 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 215 +E Y +E + + + V++ L K +E+ ++R+ + A + Sbjct: 199 TEGEYGSLEHE----NVDGVVESL-------------------KIITEKKSRRIAKFAFD 235 Query: 216 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEI 275 YA+ N+R VT +HK NIMK +G F + +++++ +I Sbjct: 236 YALQNNRRKVTAIHKANIMKLADGLFLETCREISKDY--------------------TDI 275 Query: 276 VIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF 335 + +I D Q++ P ++DV+ NL G+ +S VGGIG+ PG NIGD+ A+F Sbjct: 276 EFESMIIDNCCMQMVTNPQQFDVMVMPNLYGNIVSHIGIGLVGGIGLVPGKNIGDKYAIF 335 Query: 336 EA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDF 393 E+ G ++ NP + ++ +MLRH+G + AD+I + I N K T D Sbjct: 336 ESGARNIGSDLVGLNRANPCGFLFTSALMLRHLGLDDYADIIESAVRTTIKNGKCRTPDI 395 Query: 394 ERLMDGAKLLKCSEFGDAIIENM 416 + G + ++F DA+I+ + Sbjct: 396 Q----GDR--TTADFIDAVIKEI 412 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 112 bits (281), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 116/403 (28%), Positives = 171/403 (42%), Gaps = 66/403 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEK-----AYKGERKISWMEIYTGEKSTQVYGQDVW 83 I I GDGIGV+V P L+ +DA + AY+ I W K Q+ D Sbjct: 43 IAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYE---PIEWASCDYYAKHGQMMPDDWK 99 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV-- 141 +D + A+ P T P + + R+E D Y+ LRP R + G P P+ Sbjct: 100 TQLSGMDAL--LFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAG 157 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + D +I REN+E Y SA + + E V++ F H Sbjct: 158 RKAGDIDFMIVRENTEGEY--------SAVGGTMFEGTEREFVVQQAVFTRH-------- 201 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 GT+R+++ A E A + +T+ K N + + W A E Sbjct: 202 ---GTERVLKFAFELAQRRAK-RLTVATKSNGIAIS----MPWWDARAAE---------- 243 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 + + P+ + D++ F+ Q P +DV+ NL GD +SD A G IG Sbjct: 244 --MAARYPDVAWDKQHIDILCARFVMQ----PDRFDVVVASNLFGDILSDLGPACTGTIG 297 Query: 322 IAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----WTEAA 373 IAP AN+ E +LFE HG+AP AG+ NP ++I SA MM+ +G EA Sbjct: 298 IAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPAREAH 357 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D IV +E + T D M G + E GDAI+ ++ Sbjct: 358 DAIVAAIEHVLKHGPRTRD----MGGRASTR--EVGDAIVAHL 394 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 112 bits (279), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 101/385 (26%), Positives = 164/385 (42%), Gaps = 57/385 (14%) Query: 26 NPI-IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 +PI I + GDGIG++VT A L V + I W E + E + + Sbjct: 5 DPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGW-EFWKKEGAA--------I 55 Query: 85 PAETLDLIREYRVAIKGPLTTP--------VGGGIRSLN-------VALRQELDLYICLR 129 P+ T LI + G +T+ + ++ N + LRQ LDL+ +R Sbjct: 56 PSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVR 115 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 P P + I RENSE +Y G ++ K I L E + Sbjct: 116 PCFSIDDQSKPF------NFCIIRENSEGLYCGFDY----FPLPKAIHSLLAESQHWQTI 165 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 + ++ S+ G RL A ++A+ VTL K N+++ G F ++ Sbjct: 166 PADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLR-ESGEFTRKIFEST 224 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 + + P +I+ D +A ++ P ++ VI N+ GD + Sbjct: 225 AQRY---------------PKIQADILNVDAVALWLIKS----PEKFGVIVAENMFGDIL 265 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD A +GG+G+AP ANIGD+ + FE HG+ P+ ++ NP ++ L+ M+L H G+ Sbjct: 266 SDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGY 324 Query: 370 TEAADLIVKGMEGAINAKT-VTYDF 393 + A IV + I K +TYD Sbjct: 325 PDRAKKIVNAVMQVIKEKRFITYDL 349 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 110 bits (275), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 99/352 (28%), Positives = 166/352 (47%), Gaps = 61/352 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G ++ A+ +V AA E +S ++ E+ + + Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLE----------QV 100 Query: 89 LDLIREYRVAIKGPLTTPV--GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G + +H L Sbjct: 101 LSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT--RHNNL 158 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI RE +E Y+ +E ++ A VI+ L K + + Sbjct: 159 -DLVIIREQTEGEYSSLEHES----ARGVIECL-------------------KIVTRAKS 194 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ + A +YA R VT VHK NIMK +G F ++A EL + K+ Sbjct: 195 QRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVA------EL-----YPKI 243 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 K + +I D Q++ P ++DV+ NL G+ I + A VGG G+ PG Sbjct: 244 K---------FETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE 294 Query: 327 NIGDECALFE--ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 + E A+FE A H A + G++ NP +++LSA MLRH+ + +I Sbjct: 295 SYSAEYAVFETGARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSSMI 345 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 110 bits (275), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 102/346 (29%), Positives = 162/346 (46%), Gaps = 54/346 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG ++ ++V++AA K ++ + +I G S Q +G V PA Sbjct: 3 IVVLPGDGIGPEIMAVAVRVLEAA-SKRFQLDLEIG--HDIAGHASLQRHGATVT-PA-L 57 Query: 89 LDLIREYRVAIKGPLTT-----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ ++ + GP+ T G I R+ELDLY +RP R + G V Sbjct: 58 LEKVKAADGLMLGPMATYDFKDEAKGEINPSKF-FRKELDLYANIRPARTFPGMAHRVGE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 ++ + REN+E YA + +S +E +I P+ I ++ + Sbjct: 117 ---FNLAVVRENTEGFYA--DRNIESGSSEMLIT-------------PDTV-ISLRRITR 157 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+ R+A + A R V++VHK N++K +G F D Q+ARE P Sbjct: 158 LCCERIARSAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVAREF---------PQ 207 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++V D I DA + ++ P +DVI N+ GD +SD A G +G+ Sbjct: 208 VRVD-----------DFIVDAMMAHVVRAPQRFDVIVTTNMFGDILSDLTAELSGSLGLG 256 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 N G + A+ +A HG+AP AG++ NP S+ILSA +L GW Sbjct: 257 GSLNAGKDHAMGQAVHGSAPDIAGRNIANPYSLILSAGQLL---GW 299 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 110 bits (275), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 108/397 (27%), Positives = 169/397 (42%), Gaps = 75/397 (18%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 93 GDGIG + A L V ++K +R + ++ I G + Q+ LP L+ + Sbjct: 45 GDGIGPYIMKAALLVARKLLKKEIADQR-VEFVPI-KGMTIEERARQNKSLPPAVLEACK 102 Query: 94 EYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-TD 148 + +KGP TP G + S N LR++L LY +RP+R PE D Sbjct: 103 ACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRI----------PEKGID 152 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 FREN E Y W G K I + I K S+ G +R Sbjct: 153 WTFFRENIEGEYI---W------------------GNKGICVGDDLAIDFKILSKPGAER 191 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 L R A EYA ++ + ++T+ K NI+K +G F + + +E G Sbjct: 192 LFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPG-------------- 237 Query: 269 PNTGKEIVIKDVIADAFLQQILLRP---AEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I +++ + D+ L L+ P A V NL GD ++D A GG+G A Sbjct: 238 ------IHVREELIDS-LSAKLMDPEFNAGMQVFVLPNLYGDILTDIAAEYQGGLGTASS 290 Query: 326 ANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 +NIGD+ A+FEA HG ++ +P S+I + M+ +G+ E D + K ++ Sbjct: 291 SNIGDQYAMFEAIHGVGVYLVEHNRAQYADPSSLIRAMGEMMAFIGYPEKRDRLFKALDF 350 Query: 383 AINAK---TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +T D DGA EF + ++E + Sbjct: 351 CTKVERKAVITTD----KDGA---TAEEFAEYVVETL 380 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 109 bits (273), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 142/300 (47%), Gaps = 48/300 (16%) Query: 92 IREYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 150 I+ V +KG + T + S NVALR ELD+Y + + Y G + +H ++ D+V Sbjct: 110 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDI-DVV 166 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 I R+N+E YA +E ++ + E +K + + ++R+ Sbjct: 167 IIRQNTEGEYAMLEHESVNGVVE-----------------------SMKVVTADNSERVA 203 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 204 RFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY------------------ 245 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD 330 +I D+I D Q++ +P ++DV+ NL G +S+ + +GG G+ G N GD Sbjct: 246 --PDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLGGAGLLSGRNYGD 303 Query: 331 ECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTV 389 A+FE T T AG++ NP ++I ++ ML H+G A L+ + + IN V Sbjct: 304 HYAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEHLGHQFHASLLRRAINKTINVDRV 363 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 109 bits (272), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 102/388 (26%), Positives = 166/388 (42%), Gaps = 65/388 (16%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + G GIG ++ L+V+ AA +S+ EI+ D E L Sbjct: 43 LTGSGIGPEIMDHTLRVLKAA-------GAPLSY-EIFALSSKDGSKNNDF---DEALTS 91 Query: 92 IREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 150 IR RVA+KG + I+S N+ R+ LDL++ + + + G + K E+ D+ Sbjct: 92 IRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLSN--KFGEI-DIT 148 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 + R+N+E Y +E + + E +K + +RL+ Sbjct: 149 VIRQNTEGEYLMLEHEPRTGSVE-----------------------SLKVLTRFNLERLI 185 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 A +YA+ NDR +T+VH NI K TEG F + ++++ P +K+ Sbjct: 186 EFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSY---------PMIKMN--- 233 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI-G 329 + DV F +I P +DVI NLNG IS+ L +GG G+ G N Sbjct: 234 ------VLDVNVAIF--KIASNPRIFDVILATNLNGSMISNYLNGMLGGPGLTSGINFSA 285 Query: 330 DECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 D A+FE G ++ NP ++I+S +L H+G+ + A++I + T Sbjct: 286 DGIAVFEPGARNKGSSIVGLNRANPIAMIMSGINLLHHLGYNKTAEMIHNSVYA-----T 340 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 + YD R D E D II ++ Sbjct: 341 LVYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 109 bits (272), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 97/352 (27%), Positives = 164/352 (46%), Gaps = 59/352 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P++ + + GDGIG +V +++++ E ++ + GE Q G+ Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY--QRSGE-- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN-------VALRQELDLYICLRPVRYYQ 135 LP D + G + P +R N + LR+ L LY +RP+R Y Sbjct: 57 ALPQSAYDACLASDAVLLGAMGLP---NVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYH 113 Query: 136 GTPSPVK-H-PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +P+K H P D V+ RE++E ++ G + AD +A++ LR Sbjct: 114 EADTPLKGHGPGEIDFVLVRESTEGLFYGRDAIAD-LEADEATNLLR------------- 159 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++R+ R A E A D + +VTL+ K N++ + F+ ++A+E Sbjct: 160 -------ITRSASERVCRLAFETARRRDGKKTVTLIDKANVLS-SMVYFRHVFDEVAKE- 210 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +L +K + V DA ++ RP ++DV+ N+ GD +SD Sbjct: 211 ----------FLDIKAEH---------VYVDAAALFLVRRPQDFDVMVTENMFGDILSDL 251 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 A VGG+G+AP +IGD+ A+F+ +HG+AP AGQ NP ++ LS MML Sbjct: 252 AAGLVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMML 303 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 108 bits (270), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 93/339 (27%), Positives = 147/339 (43%), Gaps = 48/339 (14%) Query: 35 DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIRE 94 DGIG ++ A ++V+ +A + +K + + ++ G S + YG L E L + Sbjct: 9 DGIGPEIVGAAMEVLRSA-DSVFKLDLAFDYDDV--GFTSLEKYG--TTLRDEVLAKAKT 63 Query: 95 YRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 149 Y I G + P GG R+++ R LDLY +RP R S ++ D+ Sbjct: 64 YDGVILGTQSHADYPAPDKGG-RNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTMDL 122 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 VI RE +E Y A+ +M + + HC ++R+ Sbjct: 123 VIMREATEGFYPDRNMTKGWAEL-----MPSPDMAISLRKITRHC-----------SERI 166 Query: 210 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNP 269 R A E A+ + VT +HK N T+G F + +AR+ Sbjct: 167 ARRAFELAMKRKK-KVTAIHKANSFHMTDGLFLECVRDVARD------------------ 207 Query: 270 NTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329 E+ + D++ DA ++ P +DV+ N GD ISD + G +G+A Sbjct: 208 --FPEVRLDDLLIDASTAHLVRAPERFDVLVATNFYGDIISDLASELSGSLGLAGSMMAS 265 Query: 330 DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 D +A HG+AP AGQDK NP S+ILS M+++ MG Sbjct: 266 DTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQWMG 304 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 108 bits (270), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 101/372 (27%), Positives = 163/372 (43%), Gaps = 50/372 (13%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG++V A ++VV+ + G I + I G + +G+ ++ + Sbjct: 49 IASIPGDGIGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVSEDC 104 Query: 89 LDLIREYRVAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTPSPVKHP- 144 LD +R++ + G + P V I L +ALR L LY +RPVR + GT P+ Sbjct: 105 LDTLRKFDAGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTAT 164 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E D ++ RENSE Y+G + G + P + + Sbjct: 165 EGIDWMLVRENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMFTRV 205 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G +R++R A E A + R +T+V K N M+ W ++ E+ P Sbjct: 206 GIERIMRFAFEVAQSRPRKLLTVVTKSNSMR---NGMVLW------DQVAAEVAKDFP-- 254 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ ++ DA +++ +P D I NL+ D +SD AA G IG+AP Sbjct: 255 ---------DVTWDKMLVDAMTVRMVAKPQSIDTIVGTNLHMDILSDLAAALAGSIGVAP 305 Query: 325 GANIG---DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +N+ ++FE HG+A G+ NP + SA ML +G EAA ++ +E Sbjct: 306 SSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLSWLGEKEAAKQLMDCVE 365 Query: 382 GAINAKTVTYDF 393 A +T D Sbjct: 366 KVCAAGILTPDL 377 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 108 bits (269), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 113/405 (27%), Positives = 177/405 (43%), Gaps = 74/405 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V LKV++ +K K K+ + G + +G+ LP ET Sbjct: 3 IAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFG---HIGGDAIDRFGEP--LPEET 57 Query: 89 LDLIREYRVAIKG-----------PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 + E G P P GG+ +ALR+ L+LY +RP++ Y+ Sbjct: 58 KKICLEADAIFLGSVGGPKWDDLPPEKRPEIGGL----LALRKMLNLYANIRPIKVYRSL 113 Query: 138 P--SPVKHPEL---TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 SP+K + D+V RE S +Y G + L EE G + + Sbjct: 114 VHVSPLKEKVIGSGVDLVTVRELSYGVYYGQP------------RGLDEEKGFDTMIY-- 159 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + +R+ R A E A N R VT V K N++ ++ ++ ++ARE Sbjct: 160 ---------DRKTVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREY 208 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 ++ + + D Q++L+P+++DVI N+ GD +SD Sbjct: 209 --------------------PDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDE 248 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 AA G +G+ P A+ GD+ L+E G+AP AG++ NP + ILS MML H G E Sbjct: 249 SAALPGSLGLLPSASFGDKN-LYEPAGGSAPDIAGKNIANPIAQILSLAMMLEHSFGMVE 307 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I + +E I T D D K + S+ GD I + + Sbjct: 308 EARKIERAVELVIEEGYRTRDIAE--DPEKAVSTSQMGDLICKKL 350 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 107 bits (266), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 101/363 (27%), Positives = 157/363 (43%), Gaps = 70/363 (19%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDGIG +V +++A E + + EI G + +G W P + Sbjct: 15 LPGDGIGPEVMAQARDLLEAVAEPSGV---RFELDEIPCGGRFYLEHGARDW-PEDAEAR 70 Query: 92 IREYRVAIKGPLTTP---------VGGGIRSLNVAL---RQELDLYICLRPVRYY----- 134 R V + G + P +G G + + A+ R +LDLY +RPV+ Sbjct: 71 CRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGVAH 130 Query: 135 --QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 GT V PE DMVI REN+E +YAG+ + + V R Sbjct: 131 RISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRL----------- 179 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS-------VTLVHKGNIMKFTEGAFKDWG 245 + G +R++R A E R + VT + K N+++ G Sbjct: 180 --------ITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE---------G 222 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 +L E F + + P+ E+ I DAF Q ++ +P YDV NL Sbjct: 223 CKLFAEVFA--------EVASEYPDIANELAI----VDAFTQWLVTQPEHYDVCVTTNLF 270 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GD ++D + GG+G+A G N+GDE A+FE HG+AP AG+D+ NP +++L+ L Sbjct: 271 GDIVTDLASVLQGGMGMAVGCNVGDEHAMFEPIHGSAPPLAGKDEANPMAMLLATGEALA 330 Query: 366 HMG 368 +G Sbjct: 331 WLG 333 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 106 bits (265), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 104/404 (25%), Positives = 169/404 (41%), Gaps = 65/404 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD------V 82 I I DGIG +V A L+V++A E++ I+T T +G D V Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEAL-------EKRSGDFSIHT---ETFDWGSDYYKKNGV 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTPS 139 +PA+ L+ ++++ G + P V I L + + Q D Y +RP + G Sbjct: 56 MMPADGLEQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITP 115 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+++ P D VI RENSE Y+G +A PE G Sbjct: 116 PLRNCGPGDLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTE 156 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + G R++R A + A A R +T+V K N + + + ++++E Sbjct: 157 VAIFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEF----- 211 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ ++ DA ++ L+P D I NL+ D +SD A Sbjct: 212 ---------------PDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHADILSDLAGALA 256 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+AP ANI E ++FE HG+A G+ NP + +A ML H+G +AA Sbjct: 257 GSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFWTAAQMLEHLGEKDAAT 316 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLK--CSEFGDAIIENM 416 ++ +E A +T D D ++ C + I NM Sbjct: 317 RLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIAGSNILNM 360 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 106 bits (264), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 142/303 (46%), Gaps = 49/303 (16%) Query: 92 IREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 149 IR RVA+KG + T + +S N LR LDLY V +++ P V + D+ Sbjct: 23 IRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYA---NVIHWKSLPGVVTRHKDIDI 79 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 +I REN+E Y+ +E ++ + V++ L+ K +R E+ K E G K+ Sbjct: 80 LIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY---AFKLAQESGRKK- 131 Query: 210 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNP 269 VT VHK NIMK +G F Q RE + + P Sbjct: 132 ---------------VTAVHKANIMKLGDGLF----LQCCRE------------VAARYP 160 Query: 270 NTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329 +I +++I D Q++ RP ++DV+ NL G+ +++ A VGG G+ GAN G Sbjct: 161 ----QITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG 216 Query: 330 DECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 A+FE AT T A ++ NP + +L++ MML H+ A I K + +++ + Sbjct: 217 HVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNEN 276 Query: 389 VTY 391 V + Sbjct: 277 VRF 279 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 106 bits (264), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 98/361 (27%), Positives = 152/361 (42%), Gaps = 51/361 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +V PA + + E G + + G + +G V +PA+ Sbjct: 6 IATIPGDGIGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMMPADG 61 Query: 89 LDLIREYRVAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTPSPVKH-- 143 L+ +R+ + G P + I L + + Q LD Y +RP R G P+K Sbjct: 62 LEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLKRCT 121 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 E D VI RENSE Y+G+ + P + + Sbjct: 122 AEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAATDVSMMTR 162 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R++R A A + R +T+V K N + + + +++RE Sbjct: 163 AGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISRE------------ 210 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + KE+V DA +++ RPA D I NL+ D +SD AA G +GIA Sbjct: 211 --FPDVRWDKELV------DAATARMVNRPASLDTIVATNLHADILSDLAAALAGSLGIA 262 Query: 324 PGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 P NI E ++FE HG+A G+ NP S M+L H+G +AA +++ + Sbjct: 263 PTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGTFWSVVMLLEHLGEHQAAARMMRAV 322 Query: 381 E 381 E Sbjct: 323 E 323 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 103/372 (27%), Positives = 162/372 (43%), Gaps = 64/372 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I+GDGIGVDV A + V++ A++ + GE + EI G + G D+ E Sbjct: 3 IALIKGDGIGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 89 LDLIRE--YRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + + + AI P G S ++ LR LY +RPV+ Y P + P Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 147 T--DMVIFRENSEDIY--AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D+VI RE++E ++ A ++ + ++V LR + Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLR--------------------IT 160 Query: 203 EEGTKRLVRAAIEYAIANDRDS------VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + T +L R A + +A R +T V K N+ FT AF + + EF Sbjct: 161 RKTTTKLHRFA--FNLARKRRERGHPGRLTCVDKANV--FTSLAFFRQIFDEVKSEFA-- 214 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + DA ++ +P E+DV+ N+ GD +SD Sbjct: 215 -----------------DVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGDILSDLAGGL 257 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------W 369 VGG+G+A IGD LF+ HG+AP G+DK NP + ILSA +ML ++ Sbjct: 258 VGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYLAEKLDKPSL 317 Query: 370 TEAADLIVKGME 381 +AA+LI +E Sbjct: 318 ADAAELIDSAVE 329 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 98/355 (27%), Positives = 158/355 (44%), Gaps = 56/355 (15%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGER-KISWMEIYTGEKSTQVYGQDVWLPAETLD 90 I GDGIGVDVT A ++V+ AA + + + W Y E +P + ++ Sbjct: 9 IPGDGIGVDVTDAAMEVLGAAAKGRFAFDTTSFPWSCEYYLEHGRM-------MPEDGIE 61 Query: 91 LIREYRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 +R + A+ P T P + L + +R+ + Y +RP R G P+K E Sbjct: 62 TLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK-AEG 120 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++ REN+E Y+G + E+ V+ F + G Sbjct: 121 FDILCIRENTEGEYSGAGGRVHEGKGN--------EVAVETSVF-----------TRAGV 161 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R++R E A + R +T V K N K++ F D ++ RE L Sbjct: 162 ERILRFGFEQARSR-RGHLTSVTKSNAQKYSM-VFWD---EVTRE------------LAA 204 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + P+ + + + DA ++++ P + DV+ NL GD ++D AA GG+G A A Sbjct: 205 EYPD----VTVSHMHIDAMAAKMVMAPQDLDVVVASNLFGDILTDLGAAIQGGLGFAASA 260 Query: 327 NIG-DECA--LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 NI D A +FE HG+AP AG++ NP + I S ML H+G E + ++ Sbjct: 261 NINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAIWSVAQMLDHLGEAEVSAAVLS 315 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 77/277 (27%), Positives = 127/277 (45%), Gaps = 49/277 (17%) Query: 115 NVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEK 174 N + LDLY + +G +H TD+V+ REN+E Y+G+E + E Sbjct: 102 NYKFYKYLDLYSNITFAFSVEGITQ--RHNN-TDIVVIRENTEGEYSGVEHEVYPGVVE- 157 Query: 175 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 234 IK +++ + R+ A E+A + R VT VHK NIM Sbjct: 158 ----------------------SIKVTTKQASLRIAEYAFEFAHLSGRRKVTAVHKANIM 195 Query: 235 KFTEGAFKDWGYQLA-REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 K +G F ++A R F I +++I D Q++ P Sbjct: 196 KLVDGLFLQACREVAQRYSF---------------------IKYEEMIIDNCCMQLVKNP 234 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF-EATHGTAPKYAGQDKVN 352 ++DV+ NL G + + +A GG+G+A GA+IG + ALF + T AG++ VN Sbjct: 235 TQFDVMVMPNLYGSIVQNVVAGITGGVGMAAGASIGKDHALFSQGCRHTGRDIAGKNVVN 294 Query: 353 PGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTV 389 P ++++S+ ++LRH+G AD I + ++ I K + Sbjct: 295 PSAMLVSSTLLLRHLGLPNFADQICRAVQHTIQDKKI 331 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 104 bits (259), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 93/321 (28%), Positives = 138/321 (42%), Gaps = 71/321 (22%) Query: 119 RQELDLYICLRPVRYYQGTPSPVK--HPEL-----TDMVIFRENSEDIYAGIEWKADSAD 171 R L+LY +RP++ Y G + H ++ DMVI REN+E +YA K Sbjct: 87 RMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDMVIIRENTEGLYAPTGGKLAPGG 146 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS------- 224 V I + + ++++R A E ++ + Sbjct: 147 KADV-------------------AIDTRVITRRACEQVIRHAFELCKRRNKGAPKDGKLR 187 Query: 225 VTLVHKGNIMKFTEGAFKDWGYQLARE---EFGGELIDGGPWLKVKNPNTGKEIVIKDVI 281 VT + K N++ G QL R+ E G E EI I Sbjct: 188 VTAIIKDNVLH---------GCQLFRDVFFEIGAEY---------------PEIEKDTAI 223 Query: 282 ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGT 341 DAF Q ++ +P YDV N+ GD ++D + GG+G+A G NIG A+FE HG+ Sbjct: 224 VDAFTQWLVGQPEYYDVCVTSNMFGDIVTDLASTLQGGMGMAVGGNIGKHNAMFEPIHGS 283 Query: 342 APKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI--------NAKTVTYDF 393 APK+AG+DKVNP ++ILS + L + + + K E +T+TYD Sbjct: 284 APKHAGKDKVNPIAMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYD- 342 Query: 394 ERLMDGAKLLKCSEFGDAIIE 414 L+ + KCSE G AI E Sbjct: 343 --LVGNDRASKCSEVGSAIAE 361 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 103 bits (257), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 98/360 (27%), Positives = 162/360 (45%), Gaps = 62/360 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG P ++ V + A + + E++ + + +D+ Sbjct: 57 VTMIPGDGIG----PELMLHVKSVFRHACV---PVDFEEVHVSSNADE---EDIR---NA 103 Query: 89 LDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + IR RVA+KG + T + +S N LR LDLY V + + P V + Sbjct: 104 IMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYA---NVIHCKSLPGVVTRHKD 160 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I REN+E Y+ +E ++ + V++ L+ K +R E+ Sbjct: 161 IDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY------------- 203 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 A + A + R VT VHK NIMK +G F Q RE + Sbjct: 204 ------AFKLAQESGRKKVTAVHKANIMKLGDGLF----LQCCRE------------VAA 241 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + P +I +++I D Q++ RP ++DV+ NL G+ +++ A VGG G+ GA Sbjct: 242 RYP----QITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGA 297 Query: 327 NIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 N G A+FE AT T A ++ NP + +L++ MML H+ A I K + +++ Sbjct: 298 NYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMD 357 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 103 bits (257), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 99/360 (27%), Positives = 162/360 (45%), Gaps = 62/360 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG P ++ V + A + + E++ + + +D+ Sbjct: 19 VTMIPGDGIG----PELMLHVKSVFRHACV---PVDFEEVHVSSNADE---EDIR---NA 65 Query: 89 LDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + IR RVA+KG + T + +S N LR LDLY V + + P V + Sbjct: 66 IMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYA---NVIHCKSLPGVVTRHKD 122 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I REN+E Y+ +E ++ + V++ L+ K +R E+ K E G Sbjct: 123 IDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY---AFKLAQESGR 175 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K+ VT VHK NIMK +G F Q RE + Sbjct: 176 KK----------------VTAVHKANIMKLGDGLF----LQCCRE------------VAA 203 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + P +I +++I D Q++ RP ++DV+ NL G+ +++ A VGG G+ GA Sbjct: 204 RYP----QITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGA 259 Query: 327 NIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 N G A+FE AT T A ++ NP + +L++ MML H+ A I K + +++ Sbjct: 260 NYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMD 319 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 103 bits (256), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 98/363 (26%), Positives = 154/363 (42%), Gaps = 70/363 (19%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI-YTGEKSTQVYGQDVWLPAE 87 + I GDGIGVDVT +KV+D+A +I W E Y+ E+ + +P + Sbjct: 7 VATIPGDGIGVDVTREAVKVMDSATGG------RIEWTEFDYSCERYAKT---GAMMPPD 57 Query: 88 TLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK-- 142 + + + G + P + L + LR+ + Y+ LRPVR G SP+ Sbjct: 58 APTTLAGFDAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLAGV 117 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E MVI REN+E Y+ I + + + F +E +I Sbjct: 118 SDEALSMVIVRENTEGEYSPIGGVHNRGNQNE---FALQESVFTRI-------------- 160 Query: 203 EEGTKRLVRAAIEYA------IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 G +R++R A E A + + S ++H M + + F + + Sbjct: 161 --GCERIIRYAFELAASAGFRVCSATKSNGIIHS---MPYWDSIFNEIAAEYP------- 208 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 + P+ + DA +++ PA DVI NL GD +SD AA Sbjct: 209 ----------QTPSVSMHV-------DALAARMVSDPASLDVIVASNLFGDILSDLAAAI 251 Query: 317 VGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 GG+G+A NI E ++FE+ HG+AP AGQ NP + IL+ M+L H+ A Sbjct: 252 TGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQILAGAMLLDHLNEPATA 311 Query: 374 DLI 376 + I Sbjct: 312 NKI 314 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 99/343 (28%), Positives = 156/343 (45%), Gaps = 82/343 (23%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +V PA ++++A +Y G K + +++ G ++ + G LP +T Sbjct: 8 IGLIPGDGIGKEVIPAGRRILEAL--PSYLG-LKFEFTDLHAGFETFERTG--AALPDKT 62 Query: 89 LDLIR-EYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 ++++R E A+ G +++P G S VALR++LDLY +RPV+ P+ Sbjct: 63 VEILRNECDGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTVLSAAKPI---- 118 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG-IGIKPCSEE 204 DMVI REN+ED+Y E D+ D KV + ++ R G I ++ Sbjct: 119 --DMVIVRENTEDLYVKEETTRDTPDG-KVAEAIKRISERASHRIATMAGDIALR----- 170 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++ +RAA +I + VT+ HK N++ L Sbjct: 171 --RQKIRAAGAPSI-HQSPLVTITHKSNVL-----------------------------L 198 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++KN VI NL GD +SD AA VG +G+ P Sbjct: 199 RLKN-----------------------------VIVDPNLYGDILSDDAAALVGSLGLVP 229 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 AN+G+ A+ E HG+AP GQ+ NP + + SA +ML + Sbjct: 230 SANVGEGFAIGEPCHGSAPDIMGQNIANPIATLRSAALMLEFL 272 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 97.4 bits (241), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 111/371 (29%), Positives = 165/371 (44%), Gaps = 60/371 (16%) Query: 33 EGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI 92 +G+GIG ++ ++ V+ A++ + GE ++ + G ++ G+ V P ET + I Sbjct: 13 QGEGIGPEIVAPTVQAVELALQAS--GEATPEFVPLLLGREAINATGRIV--PEETWETI 68 Query: 93 REYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 I GP P G + + LR++ DL+ +RPVR G P V HP+L D Sbjct: 69 TGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVR---GVPGAV-HPDL-D 123 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN+E +YA D + MG I + I ++ TK Sbjct: 124 VVIVRENTEGMYA---------DRNML-------MGSGDITVNGEVSLAIGVFTQ--TKI 165 Query: 209 LVRAAIEYAIANDRDSV-TLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 AIA RD V T+ HK N++ T G + A EEFG E Sbjct: 166 RRIVRRAAAIAAARDGVLTVAHKSNVLTETSGRYVAEAKACA-EEFGVE----------- 213 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 ++ V DA +++ RP Y I N+ GD +SD G +GIA N Sbjct: 214 ---------VQPVHIDALCAELVTRPERYATIVAENMFGDILSDLAGGLGGSLGIAGSIN 264 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN-- 385 + + +A HG+AP AGQ NP I+ SA ML +G+ +AA+L +EGA+ Sbjct: 265 ASESQVMAQAAHGSAPDIAGQGIANPAGIMNSAAQMLDSLGYPQAAEL----LEGAVREA 320 Query: 386 -AKTVTYDFER 395 K T D R Sbjct: 321 VVKAPTADLVR 331 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 96.7 bits (239), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 101/381 (26%), Positives = 166/381 (43%), Gaps = 62/381 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE-KSTQVYGQD-VWLPA 86 I I GDGIG++V P ++V++AA K +E T E S Y Q +P Sbjct: 8 IAAIPGDGIGLEVLPEGIRVLEAAALKHGLA------LEFDTFEWASCDYYLQHGKMMPD 61 Query: 87 ETLDLIREYRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + + +++Y A+ P P + + R+E D Y+ +RPVR + G P + Sbjct: 62 DWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALA 121 Query: 143 HPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + ++ D V+ REN+E Y+ + + + E+ +++ F Sbjct: 122 NRKVGDIDFVVVRENTEGEYSSL--------GGIMFENTENEIVIQESIF---------- 163 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G R+++ A + A +R VT K N M + Y R E Sbjct: 164 -TRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAIS------MPYWDKRTEA------- 209 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA-CMNLNGDYISDALAAQVGG 319 + P+ + D++ F+ L+P +DV+ NL GD +SD A G Sbjct: 210 ---MAAHYPHVSWDKQHIDILCARFV----LQPERFDVVVVASNLFGDILSDLGPACAGT 262 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----WTE 371 IGIAP AN+ E +LFE HG+AP G++ NP ++I S +ML +G + Sbjct: 263 IGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDERYQR 322 Query: 372 AADLIVKGMEGAINAKTVTYD 392 A D ++ +E I +VT D Sbjct: 323 AHDDMLNAIERVIADGSVTPD 343 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 96.7 bits (239), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 58/144 (40%), Positives = 78/144 (54%), Gaps = 7/144 (4%) Query: 274 EIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECA 333 EI ++ D ++ P +YDV+ NL GD +SD A VGG+G+ P N+G A Sbjct: 131 EIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGA 190 Query: 334 LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK-GMEGAINAKTVTYD 392 LFE+ HGTAP AG+D NP +++LSA MMLRHM AD I + E K +T D Sbjct: 191 LFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGD 250 Query: 393 FERLMDGAKLLKCSEFGDAIIENM 416 G + KCSEF + I + Sbjct: 251 L-----GGR-AKCSEFTNEICAKL 268 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 96.3 bits (238), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 95/348 (27%), Positives = 151/348 (43%), Gaps = 60/348 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG +VT A LKV+ A E G +++ G + +G+ P T Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLG---LAYEVFPFGGAAIDAFGEP--FPEPT 57 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-RSLN-----VALRQELDLYICLRPVRYYQGTP--SP 140 + E + G + P G+ R + ++LR+ DL+ LRP + + G SP Sbjct: 58 RKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSP 117 Query: 141 VKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +K D++I RE + IY G A+A ++ + E+ Sbjct: 118 LKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEV--------------- 162 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 +R+ R A E A R V V K N+++ G F ++ EE G Sbjct: 163 --------ERVARVAFE-AARKRRKHVVSVDKANVLEV--GEF----WRKTVEEVG---- 203 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 G P ++ ++ DA ++ PA +DV+ N+ GD +SD + G Sbjct: 204 RGYP-----------DVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPG 252 Query: 319 GIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 +G+ P A++G +FE HG+AP AG+ NP + ILSA MML H Sbjct: 253 SLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEH 300 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 96.3 bits (238), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 104/400 (26%), Positives = 174/400 (43%), Gaps = 63/400 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG +V +KV++ EK K+++ E + G + G LPAET Sbjct: 6 VAVLAGDGIGPEVMAEAMKVLNKVQEKF---GFKLNFNEFFVGGAAIDHCGYP--LPAET 60 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPS-- 139 L E + G + P + R + LR+ L+ LRP Y+G Sbjct: 61 LKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFC 120 Query: 140 PVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 P++ + DMV+ RE + IY G + K + + F E +I Sbjct: 121 PLRADIAAKGFDMVVVRELTGGIYFG-QPKGREGEGSQTKAFDTEVYYKYEI-------- 171 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 +R+ RAA E A+ ++ VT V K N+++ + +++ ++A++ Sbjct: 172 ----------ERIARAAFEAAMKRNK-KVTSVDKANVLQ-SSILWRETVTEMAKDY---- 215 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 E+ ++ + D Q++ P +DV+ C N+ GD ISD A Sbjct: 216 ----------------PEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMI 259 Query: 317 VGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A++ + L+E G+AP AG+ NP + ILSA MMLR+ EAAD Sbjct: 260 TGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLNEAAD 319 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 I ++ + + T D L D + + +E G I + Sbjct: 320 AIESAVQKVLASGHRTAD---LADDSTPVSTAEMGTLITQ 356 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 95.9 bits (237), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 100/366 (27%), Positives = 155/366 (42%), Gaps = 65/366 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVD-AAVEKAYKGE-RKISWMEIYTGEKSTQVYGQDVWLPA 86 I + GDGIG DVT A V++ A + E + W Y E + +PA Sbjct: 6 IALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPWSCDYYLENGSM-------MPA 58 Query: 87 ETLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + ++ ++ + + G P P + L + +R+ Y +RP R G P++ Sbjct: 59 DGIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPLR 118 Query: 143 HPELTDMVIFRENSEDIYAG----IEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 D++ REN+E Y+G I AD+ A + F R+ Sbjct: 119 SDGF-DILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRK----------------- 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 G +R++R E A A R + V K N K++ F E+ Sbjct: 161 ------GVERILRFGFEQARAR-RGKLASVTKSNAQKYSM-------------VFWDEIT 200 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 G L + P ++ + DA ++++ P DV+A NL GD ++D AA G Sbjct: 201 HG---LSAEYP----DVEVTSYHIDAMAARMVMAPESLDVVAASNLFGDILTDLGAAIQG 253 Query: 319 GIGIAPGANIG-DECA--LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 G+G A ANI D A +FE HG+AP A NP + I S MML H+G T AA+ Sbjct: 254 GLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLEHLGETAAAEK 313 Query: 376 IVKGME 381 ++ +E Sbjct: 314 VMDAIE 319 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 95.1 bits (235), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 101/353 (28%), Positives = 156/353 (44%), Gaps = 66/353 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++T + ++V++ EK G +S+ G + +G LP +T Sbjct: 5 ITVIPGDGIGKEITDSAVEVLEKVDEKFGLG---LSYTYKDAGGTAYDKFGTP--LPDDT 59 Query: 89 LDLIREYRVAIKGPLTTPVGG--------GIRSLN--VALRQELDLYICLRPVRYYQGTP 138 ++ + A G L VGG +R + LR+ L LY LRPV+ Sbjct: 60 IEACK----ASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALV 115 Query: 139 --SPVKHPEL---TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP+K PEL D+VI RE IY G + +++ + + ++ PE Sbjct: 116 EYSPLK-PELVKGVDLVIVRELIGGIYFGDKCESEQHNGAE------RAWDLENYSVPE- 167 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 R+ + A E A R VT V K N++ + + W +A Sbjct: 168 ------------VDRIAKLAFETAKLR-RGKVTSVDKANVLATS----RLWRRTVA---- 206 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 K + ++ + ++ D Q+ +RP ++DVI NL GD +SD Sbjct: 207 -------------KVAESYPDVELNNLYVDNCAMQLAIRPTQFDVIVTGNLFGDILSDEA 253 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 A G IG+ P A+IG +L+E HG+AP AG+ NP ILSA M+LR+ Sbjct: 254 AVVGGSIGMMPSASIGTSTSLYEPIHGSAPDIAGKGIANPMGTILSAAMLLRY 306 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 94.4 bits (233), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 83/314 (26%), Positives = 139/314 (44%), Gaps = 54/314 (17%) Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I W +++ K G+DV + L+ + ++ IKGP + G +R L R++ Sbjct: 16 IDW-DVFHEHKINSAEGEDV--SPKLLESLCRNKIGIKGPFES--GPCLRKL----RKKF 66 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 L+ + R +G + ++ +L D +I R+ E Y+GIE + Sbjct: 67 QLFAFVAVCRNLEGQNT--RYGKL-DCLIIRDQVEGEYSGIEHRVVP------------- 110 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 GV + IK + EG R+ R EYA N+R +T+ HK NIM+ T+G F Sbjct: 111 -GVMQT---------IKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLTDGTFL 160 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + RE + +I+ ++ D +L++P DV+ Sbjct: 161 S---PMRREAAKYQ----------------DDIMFEERYLDTVCLAMLMKPERKDVLVAS 201 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362 ++ GD ++ A+ +GG + PG +G ++E T AG+D VNP ++LS + Sbjct: 202 SMYGDVLTFMAASIMGGPALCPGFAVGPMGLIYEPIIHTNTNIAGKDIVNPTGMLLSGVL 261 Query: 363 MLRHMGWTEAADLI 376 MLR M E AD I Sbjct: 262 MLREMKLNEYADKI 275 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 94.0 bits (232), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 92/362 (25%), Positives = 147/362 (40%), Gaps = 57/362 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKA--YKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG DVT A +V+ + W + E +P Sbjct: 6 IALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPWSCAFYKETGAM-------MPP 58 Query: 87 ETLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + ++ +R + + G P P + L + +R+ Y +RP R G P+K Sbjct: 59 DGIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK 118 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D++ REN+E Y+G + A+ E+ V+ F + Sbjct: 119 -AEGFDILCIRENTEGEYSGAGGRVHQGTAD--------EVAVETSIF-----------T 158 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R + A R + V K N K++ + + +LA E Sbjct: 159 RTGVERILRFGFDQA-RQRRRKLASVTKSNAQKYSMVLWDEITRELAAEY---------- 207 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + DA ++++ P DV+ NL GD ++D AA GG+G Sbjct: 208 ----------PDVEVTSYHIDAMAARMVMAPESLDVVVASNLFGDILTDLGAAIQGGLGF 257 Query: 323 APGANIG-DECA--LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 A ANI D A +FE HG+AP A NP + I S MML H+G AA +++ Sbjct: 258 AASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLDHLGQARAARKVIEA 317 Query: 380 ME 381 +E Sbjct: 318 LE 319 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 93.6 bits (231), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 97/374 (25%), Positives = 160/374 (42%), Gaps = 64/374 (17%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDGIG ++ L +++ + Y +I E G S +G+ L +TL+ Sbjct: 8 LPGDGIGPEILNGSLSLLEI-ISNKYNFNYQIEHHEF--GGASIDTFGEP--LTEKTLNA 62 Query: 92 IREYRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS--PVK--H 143 + AI GP T + LR+ L+L+ +RP +G S P+K Sbjct: 63 CKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKAER 122 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 E TD+VI RE + IY G ++ +A + + REE+ Sbjct: 123 VEGTDLVIVRELTSGIYFGEPRYFNNHEALDSLTYTREEI-------------------- 162 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+V A + A A+ R +T V K N++ ++ W Sbjct: 163 ---ERIVHVAFKLA-ASRRGKLTSVDKENVLASSK-----------------------LW 195 Query: 264 LKVKN--PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 KV N E+ + ++ DA ++ P ++DVI NL GD +SD + G +G Sbjct: 196 RKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVYENLFGDILSDEASVIPGSLG 255 Query: 322 IAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKG 379 ++P A+ ++ L+E HG+AP AG++ NP +ILS M LR + +AAD + + Sbjct: 256 LSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADELEQH 315 Query: 380 MEGAINAKTVTYDF 393 + I T D Sbjct: 316 IYNMIEHGQTTADL 329 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 100/392 (25%), Positives = 161/392 (41%), Gaps = 77/392 (19%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDGI +++ A+ V DA +I ++ + ++S + G ++ AE Sbjct: 14 LHGDGIARELSQAVHTVADAL-------PFEIEFIPVDLSDESREAKGDAIYDEAEAA-- 64 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 151 +R Y ++K P T S N LR+ + + RPV G + + E + I Sbjct: 65 MRRYGTSLKYPTATTK----ESPNRVLRERCNFAVIHRPVATIPGIQT--HYNERIHLDI 118 Query: 152 FRENSEDIY--AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 R + Y AG D+A + I+ + V RF Sbjct: 119 VRIATGGTYEDAGRRINRDTAVS---IRAIERRPSVLASRFA------------------ 157 Query: 210 VRAAIEYAIANDRDS-VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + +A RDS V K I K T+G F++ +AR+ E Sbjct: 158 ------FRLAQLRDSNVIATSKYTIQKATDGLFQEAARGVARDYPATEF----------- 200 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 ++ + DA L I++RP Y VI C N GD++SD +G IG+ A+ Sbjct: 201 ---------REELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGLIGSIGLGDSASY 251 Query: 329 GDEC------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 + A+F+ GTAP AGQ+K NP + +L+ MLRH+G +++ + + G Sbjct: 252 SFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAMANMLRHIGEHDSSKALRGALFG 311 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 AI A E+ D L SEF I++ Sbjct: 312 AIEAG------EKTADIGGSLNLSEFTQVIVD 337 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 92.4 bits (228), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 97/369 (26%), Positives = 154/369 (41%), Gaps = 67/369 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG ++T A ++ E +I W + + +G V P ET Sbjct: 17 ITLLPGDGIGPEITDACRGLIADVFPHWELTETQIGWSQW-------RAHGNPV--PQET 67 Query: 89 LDLIREYRVAIKGPLTTP---------------VGGGIRSLNVALRQELDLYICLRPVRY 133 + + A+ +T+ G RS + LRQ LDL+ +RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPVTL 127 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAG------IEWKADSADAEKVIKFLREEMGVKK 187 D I REN+E +Y+ + ADS + + + + Sbjct: 128 PGAA---------ADFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARA 178 Query: 188 IRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAN---DRDS-----VTLVHKGNIMKFTEG 239 + + ++ + RL R A + A+A + DS VT+ K NI++ + Sbjct: 179 VDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSAR 238 Query: 240 AFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 + ++A EE+ ++ ADA Q++ PA +DVI Sbjct: 239 VIRGAVEEVA-EEY-------------------PQVAFDFANADAVAMQLVTDPARFDVI 278 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILS 359 NL GD +SD A +GG+G+A AN+GD A+FE HG+AP AG+ NP + +LS Sbjct: 279 IAENLIGDILSDIGAGLIGGLGLAASANVGDNFAVFEPVHGSAPDIAGRGIANPAAFLLS 338 Query: 360 AEMMLRHMG 368 A M H+G Sbjct: 339 AAMCAEHLG 347 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 92.0 bits (227), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 129/285 (45%), Gaps = 53/285 (18%) Query: 116 VALRQELDLYICLRPVRYYQGTP--SPVKH--PELTDMVIFRENSEDIYAGIEWKADSAD 171 +ALR+EL + LRPV SP++ E D++I RE + Y G E + Sbjct: 93 LALRRELGTFANLRPVAAIPALSGSSPLRPGVAEGVDLLIVRELTGGAYFG-EKEEGEER 151 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 231 A + + R E+ +R+ R A E A R V V K Sbjct: 152 ASDLSVYTRGEV-----------------------ERVARVAFEAARGR-RGRVASVDKA 187 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILL 291 N++ + + W + GE+ P ++ ++ V+ DA ++ Sbjct: 188 NVLATS----RLWRRVV------GEVARDYP-----------DVALEHVLVDAAAMHLVT 226 Query: 292 RPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECA--LFEATHGTAPKYAGQD 349 P +DVI NL GD +SD A G +G+ P A++G+ + +FE HG+AP AG+ Sbjct: 227 DPGRFDVILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKG 286 Query: 350 KVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 NP + ILSA MM RH +G EAA+ I +G+E A+ A +T D Sbjct: 287 VANPYAAILSAAMMFRHGLGRPEAAEAIERGVEAAVAAGCLTPDL 331 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 92.0 bits (227), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 92/349 (26%), Positives = 146/349 (41%), Gaps = 68/349 (19%) Query: 56 AYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN 115 AY RK W +I +V+ D+ I +V +KGP T +S++ Sbjct: 111 AYSYLRKEKWSQI-----DPEVHYPDLH------QSILNNKVVLKGPFIT--RDVSKSID 157 Query: 116 VALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMVIFRENSEDIYAGIEWKADSADAEK 174 L + LY + PV+ Q P V P DMV+ REN+E Y+G+E + E Sbjct: 158 RMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMVVVRENTEAEYSGLEHQVQPGVVE- 216 Query: 175 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 234 +K + +G+ R+ + A EYA + R V +HK NIM Sbjct: 217 ----------------------SLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIM 254 Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 K ++G F + Q+A+E +I ++I D + Q++ P Sbjct: 255 KKSDGLFIECCKQVAKEY--------------------PDIQYSELIVDNAVMQLVKNPH 294 Query: 295 EYD--VIACMNLNGDYISDALAAQVGGIGIAPGANIG-----DECALFE-ATHGTAPKYA 346 +D V+ NL G +S+ ++ VGG+G+ G N D +FE A + Sbjct: 295 SFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNATDINKPDAVRVFEQGNRHVAMDIS 354 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI---NAKTVTYD 392 G+ NP +I S+ ML HMG A+ I ++ + N K +T D Sbjct: 355 GRLIANPIGLISSSIQMLDHMGMNTHANRIKFALKETLLNANPKILTPD 403 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 91.7 bits (226), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 95/388 (24%), Positives = 161/388 (41%), Gaps = 68/388 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I G+G+G ++ A+ +V+ A + I W +++ K+ DV E Sbjct: 89 VTLINGEGVGRELMDAVQEVICAV-------KAPIEW-DVHDEFKAKD--SDDV--SPEV 136 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L +R +V IKGP+ + R +R++ + + + +G SP D Sbjct: 137 LKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGD---FD 187 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI R+ E Y+GIE V+ + + IK + G R Sbjct: 188 VVIIRDQMEGDYSGIE--------HLVVPGVMQT---------------IKVSTTAGAAR 224 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + YA+ N R +T+ HK NIM+ T+G F + R E + D Sbjct: 225 IAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF----LEAMRAEADKHVDD--------- 271 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 ++ ++ D + +ILL+P + DV+ ++ GD + +G GI PG ++ Sbjct: 272 ------VLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSV 325 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 +F+ AG+D NP +LSA +MLRH+ + AD + + AI Sbjct: 326 SSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQV----DCAIRKVY 381 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 D R D KCSEF A+ + + Sbjct: 382 KDTDI-RTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 91.7 bits (226), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 100/173 (57%), Gaps = 13/173 (7%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEK 73 I L L +P++ I YIEGDG G ++T AM+ V++A+E AY G + I W +IY G + Sbjct: 3 IKLDGNHLIIPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGRE 62 Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRY 133 + + YG+ +LP E+++ IR+ +KGPL++ + G +N+ +++ L+LY ++ + Sbjct: 63 AYEKYGK--YLPRESIEDIRKTVFVMKGPLSSNING--HDININIKRILNLYTDVKCI-- 116 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 G P + E+ IF + +++Y + DS D++ + ++L++ + Sbjct: 117 -TGLPGLSEGKEI---FIFSPSIDEVY---HFSYDSEDSDMLRQYLQQSFNIS 162 Score = 51.6 bits (122), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 31/92 (33%), Positives = 52/92 (56%), Gaps = 4/92 (4%) Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 GA +GD +LFE+ + G D +P S +L++ MMLR + + +AA LI++ ++ Sbjct: 266 GAILGDFISLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDAA-LILRNALNSV 324 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + L +G LKCS+F DAI++ M Sbjct: 325 YSDGILPASLNLNNG---LKCSDFIDAIVKRM 353 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 90.9 bits (224), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 88/312 (28%), Positives = 135/312 (43%), Gaps = 57/312 (18%) Query: 118 LRQELDLYICLRPVRYYQG-TPSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAE 173 LR++L+L+ LRP + + EL D++I RE + +Y G Sbjct: 98 LRKDLELFANLRPAMVFDALAEASTLKTELVSGLDVMIVRELTGGVYFG----------- 146 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA-IEYAIANDR-DSVTLVHKG 231 + G+ + E G+ + T +VR A + + +A R + V K Sbjct: 147 -------QPRGISALPNGERRGVNTQVYD---THEIVRVAKVAFDLAGKRGKRLCSVEKA 196 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILL 291 N+M+ L REE L P EI + + AD Q++ Sbjct: 197 NVME---------SGLLWREEV--------TKLGADYP----EIALSHMYADNCAMQLVR 235 Query: 292 RPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI------GDECALFEATHGTAPKY 345 +P ++DVI NL GD +SD A G +G+ P A++ G+ A++E HG+AP Sbjct: 236 QPKQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDI 295 Query: 346 AGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK 404 AGQDK NP + ILS MMLR+ E ADL+ + G + T D G L+ Sbjct: 296 AGQDKANPLATILSFSMMLRYSFDLAEEADLVDNAVRGVLAKGLRTGDI--FQPGKTLVG 353 Query: 405 CSEFGDAIIENM 416 + GDA++ M Sbjct: 354 TTGMGDALLAEM 365 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 90.9 bits (224), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 105/387 (27%), Positives = 166/387 (42%), Gaps = 65/387 (16%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDGIG ++ L+++ EK Y E + G S YG L ETL Sbjct: 8 LPGDGIGPEILSGTLELLKLISEK-YHFEYHLESHHF--GGVSIDYYGTP--LTNETLQS 62 Query: 92 IREYRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP--SPVKHP- 144 + AI GP T + LR+ L+L+ +RP +G SP+K Sbjct: 63 CKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDI 122 Query: 145 -ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 E TD+VI RE + IY G +A +K+ +E+ Sbjct: 123 VEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-------------------- 162 Query: 204 EGTKRLVRAAIEYAIANDR-DSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +R+VR I + +AN R +T V K N++ + K W Q+ + Sbjct: 163 ---ERIVR--IAFNLANRRRKKLTSVDKENVL----SSSKLW-RQIVND----------- 201 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 +K P E+ + ++ DA ++ +P ++DVI NL GD +SD + G +G+ Sbjct: 202 -VKKDYP----EVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIPGSLGL 256 Query: 323 APGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGM 380 +P A+ G L+E HG+AP A +DK NP ++LS + LR + +AA+ + + Sbjct: 257 SPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANELESIV 316 Query: 381 EGAINAKTVTYDF---ERLMDGAKLLK 404 I + T D R + KLLK Sbjct: 317 YSFIQSNKTTADLGGQYRTSEIFKLLK 343 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 90.5 bits (223), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 85/330 (25%), Positives = 137/330 (41%), Gaps = 56/330 (16%) Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 E L +R +V IKGP+ + R +R++ + + + +G SP Sbjct: 34 EVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGD--- 84 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI R+ E Y+GIE V+ GV + IK + G Sbjct: 85 FDVVIIRDQMEGDYSGIE--------HLVVP------GVMQT---------IKVSTTAGA 121 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 R+ YA+ N R +T+ HK NIM+ T+G F + R E + D Sbjct: 122 ARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF----LEAMRAEADKHVDD------- 170 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ ++ D + +ILL+P + DV+ ++ GD + +G GI PG Sbjct: 171 --------VLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGY 222 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 ++ +F+ AG+D NP +LSA +MLRH+ + AD + + AI Sbjct: 223 SVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQV----DCAIRK 278 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D R D KCSEF A+ + + Sbjct: 279 VYKDTDI-RTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 89.7 bits (221), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 52/125 (41%), Positives = 72/125 (57%), Gaps = 6/125 (4%) Query: 285 FLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEATHGTAP 343 F + ++ P+++DV+ NL GD +SD A +GG+G+ P NIG + A+FE+ HGTAP Sbjct: 26 FSRGMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAP 85 Query: 344 KYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLL 403 AG+D NP +++LSA MMLRHMG A I I K V + + G Sbjct: 86 DIAGKDMANPTALLLSAVMMLRHMGLHGHAKKIETACFDTIRDKKV---LTKDLGGNP-- 140 Query: 404 KCSEF 408 KCSEF Sbjct: 141 KCSEF 145 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 89.4 bits (220), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 89/305 (29%), Positives = 136/305 (44%), Gaps = 56/305 (18%) Query: 125 YICLRP-VRYYQGTPSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 + LRP + + Q + PE+ D++I RE + IY G Sbjct: 106 FANLRPAICFEQLVDASTLKPEIVSGLDIMIVRELTGGIYFG------------------ 147 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA-IEYAIANDR-DSVTLVHKGNIMKFTE 238 E G+K I E GI + T +VR A + + +A R + VT K N+M+ Sbjct: 148 EPRGIKPIENGERKGINTHSYT---TSEIVRVAKVAFDLARKRSNRVTSCEKSNVME--- 201 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 QL +EE EL D K++ + ++AD Q+L P ++DV Sbjct: 202 ------AGQLWKEEVQ-ELHD----------KEYKDVELSHMLADNCAMQLLKNPKQFDV 244 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDEC------ALFEATHGTAPKYAGQDKVN 352 I NL GD +SD + G +G+ P A++G + A++E HG+AP AG++ N Sbjct: 245 IVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIAN 304 Query: 353 PGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDA 411 P + ILS M LR+ + AD + K ++ +N T D L G K + S GDA Sbjct: 305 PIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDI--LSQGKKEVSTSAMGDA 362 Query: 412 IIENM 416 II + Sbjct: 363 IISKL 367 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 88.6 bits (218), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 104/406 (25%), Positives = 168/406 (41%), Gaps = 71/406 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE-RKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG P ++ V ++KA E + + E+ G + + G V LP E Sbjct: 49 IALLPGDGIG----PEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVG--VPLPEE 102 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR--SLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 T + + G + GG + LR E+ L+ R ++ + P+ Sbjct: 103 TFTAAKLSDAILLGAI-----GGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQ 157 Query: 146 LTD-------------MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 L D M+I RE + IY G E G+ E Sbjct: 158 LVDASTLKKEVAEGVDMMIVRELTGGIYFG------------------EPRGITINENGE 199 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 G+ + + R+ R A E A R + V K N++ A W ++ Sbjct: 200 EVGVSTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWRKRVT--- 251 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 L + P+ + + + D Q++ P ++D I N+ GD +SD Sbjct: 252 ----------ALASEYPD----VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDE 297 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 + G IG+ P A++G+ LFE HG+AP AGQDK NP + ILSA M+L++ +G Sbjct: 298 ASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEE 357 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA I + A+N T D G KL+ C E G+ +++++ Sbjct: 358 KAAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEEVLKSV 401 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 85.1 bits (209), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 101/406 (24%), Positives = 169/406 (41%), Gaps = 85/406 (20%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVE-KAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I G+GIG +V A LK++ + + + + W+ G + + G + P Sbjct: 11 IVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVDYGWL----GATAFEQLGS--YFPQA 64 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR-----YYQGTPSPVK 142 T +L + G ++ GG+ + LR+ D + LRP+R ++ + P K Sbjct: 65 TTELCDGADGIVFGAVSQ---GGL----LELRKHFDFFCNLRPIRSVNSLLHKSSLRPEK 117 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 L D++I RE IY G ++ R G +R+ Sbjct: 118 IQGL-DILIVRELVSGIYFGPSGRSSDE---------RGNYGYHTMRY-----------Y 156 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +E +R+ R A+E A R +T+ HK N + W +L +EE Sbjct: 157 DEEIRRIARKALEQA-QYRRGLLTVAHKENALPHLH-----W-TRLVQEE---------- 199 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 K PN ++++ ++ D Q++L P +DVI NL GD +SD A VG IG+ Sbjct: 200 --ATKFPN----VIVEPMLVDNLAMQMVLNPQRFDVILASNLFGDILSDIGGALVGSIGL 253 Query: 323 APGANI-GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT----------- 370 A++ + L+EA HGTAP AG NP + + +ML+ G Sbjct: 254 LGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLGACVLMLQQWGEVQAAQQIIAAQD 313 Query: 371 -------EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 ADL +G E +N T+ + L++ +++ S+ G Sbjct: 314 RILAKGYRTADLFTQGEEILVNTATLV---DLLLEELSVVQHSQLG 356 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 83.6 bits (205), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 96/394 (24%), Positives = 170/394 (43%), Gaps = 66/394 (16%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 + GDG+G +V + +V+ VE+ Y + Y G + + GQ LP TL Sbjct: 8 LAGDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEYFGGVAIDLTGQP--LPQRTLAA 62 Query: 92 IREYRVAIKGPLTTPVGGGIRSLN----VALRQELDLYICLRPVRYYQGTP--SPVKHPE 145 + G + P + +ALR+ L ++ +RPV T SP+K+ + Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D V+ RE + IY + A + + R E+ Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTEEVATDTLTYHRHEI---------------------- 160 Query: 206 TKRLVRAAIEYAIANDRDS-VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R+V A + +AN R VT + K N+++ + K W + EE + Sbjct: 161 -ERIVSYA--FQLANKRKKKVTSIDKANVLESS----KLW--RTVTEE-----------V 200 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ PN + ++ ++ DA +++ P +DVI NL GD +SD + G +G+ P Sbjct: 201 ALRYPN----VEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLP 256 Query: 325 GANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADLIVKGMEG 382 A+ ++ +L+E HG+AP AG++K NP +++ S MML + G T I + + Sbjct: 257 SASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEEAVSA 316 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + G + + F A+I+ M Sbjct: 317 VLKSGKCTAD----IGGTE--TTTSFTKAVIQEM 344 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 83.6 bits (205), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 106/424 (25%), Positives = 174/424 (41%), Gaps = 69/424 (16%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER-KISWM 66 P+ + T++ P+ I + GDGIG P ++ V ++ A E + + Sbjct: 125 PSSIRLATIRCSAATPPKRYSITLLPGDGIG----PEVISVAKNVLKLAGSLEGIEFGFQ 180 Query: 67 EIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN----------V 116 E+ G + + G V LP ETL + ++ + G +GG N + Sbjct: 181 EMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGA----IGGYKWDSNEKHLKPETGLL 234 Query: 117 ALRQELDLYICLRPV----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADA 172 LR L ++ LRP + + + E D+++ RE + IY G Sbjct: 235 QLRSGLKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFG---------- 284 Query: 173 EKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGN 232 K F + E G E G + + R+ R A E A R + V K N Sbjct: 285 -KPRGFSKNENG-------EEIGFNTEVYATYEIDRIARIAFETA-QKRRGKLCSVDKAN 335 Query: 233 IMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR 292 +++ A W ++ E D + + + D Q++ Sbjct: 336 VLE----ASMLWRKRVT--AMASEYPD---------------VELSHMYVDNAAMQLVRN 374 Query: 293 PAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKV 351 P ++D I N+ GD +SD + G IG+ P A++G+ LFE HG+AP AGQDK Sbjct: 375 PKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKA 434 Query: 352 NPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGD 410 NP + +LSA M+LR+ +G AA I + ++ T D G KL+ C E G+ Sbjct: 435 NPLATVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEA--GTKLVGCKEMGE 492 Query: 411 AIIE 414 +++ Sbjct: 493 QVLK 496 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 82.0 bits (201), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 52/137 (37%), Positives = 77/137 (56%), Gaps = 14/137 (10%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG +++ +++K+ DAA K+ +E T + VY + L E+ Sbjct: 4 ITLIPGDGIGYEISESLVKIFDAA---------KVP-VEFETENAGSDVYEKTGELIPES 53 Query: 89 L-DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L + + ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + Sbjct: 54 LYESVERNKIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRYDN---I 110 Query: 148 DMVIFRENSEDIYAGIE 164 D+ IFREN+E IY G E Sbjct: 111 DLAIFRENTEGIYIGEE 127 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 80.9 bits (198), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 84/308 (27%), Positives = 138/308 (44%), Gaps = 53/308 (17%) Query: 118 LRQELDLYICLRPVRYYQG-TPSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAE 173 LR+++ LY LRP Y S PE+ D++I RE + +Y G + + Sbjct: 96 LRKDMQLYANLRPAICYPALAHSSSLKPEVIEGLDILILRELTGGVYFG--------EPK 147 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNI 233 ++I ++G + R GI + +R+ A E A R+ VT + K N+ Sbjct: 148 EII-----DLGNGQKR-----GIDTQVYDTYEIERIADVAFELA-RTRRNKVTSMEKRNV 196 Query: 234 MKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 MK G L + G + ++ ++ ++ ++ADA Q++ P Sbjct: 197 MK------------------SGVLWNQG--VTARHKEKHADVQLEHMLADAGGMQLVRWP 236 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI-------GDECALFEATHGTAPKYA 346 ++DVI NL GD +SD A G +G+ P A++ G AL+E HG+AP A Sbjct: 237 KQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIA 296 Query: 347 GQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 G+ NP ++I S M LR+ G AD + + G ++ T D +G + Sbjct: 297 GKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDGIRTADI--WSEGNTKVGT 354 Query: 406 SEFGDAII 413 +E GDAI+ Sbjct: 355 TEMGDAIL 362 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 80.1 bits (196), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 92/347 (26%), Positives = 144/347 (41%), Gaps = 57/347 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG ++ + L V++ E+ G + + G Q G E Sbjct: 9 IAVLPGDGIGPEIVASSLHVLEVLNER--MGGIGFDFWHLEGGAAHYQKTG--TAFSDEN 64 Query: 89 LDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--K 142 + ++ + G + P G + + LR E+DLY LRP+R Y P + K Sbjct: 65 MAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDK 124 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D+V+ RE +E I + R ++ R + S Sbjct: 125 RASQIDLVLVREQTEGIL-----------------YSRCRGTIEDDRVAWETMM----IS 163 Query: 203 EEGTKRL----VRAAIEYAIANDR-DSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 GT R+ R A A + R V V + N + T AF R FG E+ Sbjct: 164 RNGTSRVSEFAFRVAERRAKSRRRPGKVLCVDRSNAL--TSMAF-------FRRIFG-EV 213 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + ++P+ + D A +++ P E+DV+ N G +SD A V Sbjct: 214 AE-------RHPSVSADYAYVDTTA----MKLVKSPWEFDVLVTENAFGGILSDLAAGVV 262 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 G +G+AP A+IG++ A+F+ HG+AP AGQ NP + ILS +ML Sbjct: 263 GSLGLAPSADIGEKHAVFQPAHGSAPHIAGQGLANPVAQILSVALML 309 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 78.6 bits (192), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 106/261 (40%), Gaps = 64/261 (24%) Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKV 175 LR+ LDL+ C RP G P P+ P TD+++ RENSE Y Sbjct: 103 LRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEYV-------------- 148 Query: 176 IKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS----------- 224 ++ G P ++ + GT+R++R A E A + Sbjct: 149 -----DQGGRLAAGTPRETATQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAA 203 Query: 225 --------VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIV 276 V +V K N +++ + + ++A E G I Sbjct: 204 ADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPG--------------------IA 243 Query: 277 IKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE----C 332 + DA + + +P ++DV+ NL+GD ++D A GG+G+AP AN+ Sbjct: 244 THHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVP 303 Query: 333 ALFEATHGTAPKYAGQDKVNP 353 LFE THG+AP AG D+ +P Sbjct: 304 PLFEPTHGSAPDIAGADRAHP 324 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 77.8 bits (190), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 100/402 (24%), Positives = 167/402 (41%), Gaps = 60/402 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V KV++ A K + +I+ + G + +G LP T Sbjct: 4 IAILAGDGIGPEVMVEAKKVLNTV---ASKFDFEITTQDYDIGGAAIDNHGN--ALPDST 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPS-P 140 + E + G + P + R + LR DL+ +RP S Sbjct: 59 MAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLS 118 Query: 141 VKHPELT----DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 +++ D+++ RE + DIY G E K + E EE G + + Sbjct: 119 TLRSDISEQGFDVLVIRELTGDIYFG-EPKGRRGEGE-------EETGFDSMFY------ 164 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 S KR+ A + A + + VT V K N++ ++ W Q+ E Sbjct: 165 -----SRREVKRISHLAFQAAQKRN-NKVTSVDKANVLATSQL----W-RQVVEE----- 208 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 + V+ P ++ ++ + D Q++ P ++DV+ C NL GD +SD A Sbjct: 209 -------VAVEYP----DVELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAMI 257 Query: 317 VGGIGIAPGANI-GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A++ D ++E G+AP AG NP + ILSA +MLR+ + AA Sbjct: 258 TGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAAK 317 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + A++ +T D + SE GD I + + Sbjct: 318 AIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 77.4 bits (189), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 84/308 (27%), Positives = 138/308 (44%), Gaps = 53/308 (17%) Query: 118 LRQELDLYICLRPVRYYQGTPSPVK-HPELT---DMVIFRENSEDIYAGIEWKADSADAE 173 LR++L L+ LRP Y S PEL D++I RE + +Y G + + Sbjct: 96 LRKDLQLFANLRPAICYPALASASSLKPELVEGLDILIIRELTGGVYFG--------EPK 147 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNI 233 ++I ++G + R GI + +R+ A E A ++ V + K N+ Sbjct: 148 EII-----DLGNGQKR-----GIDTQVYDTYEIERIAGVAFEMA-RTRQNRVCSMEKRNV 196 Query: 234 MKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 MK G W Q+ E + D + ++ ++ADA Q++ +P Sbjct: 197 MK--SGVL--WN-QVVTETHKAKYSD---------------VQLEHMLADAGGMQLVRQP 236 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI-------GDECALFEATHGTAPKYA 346 ++DVI NL GD +SD A G +G+ P A++ G AL+E HG+AP A Sbjct: 237 KQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIA 296 Query: 347 GQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 G+ NP ++I S M LR+ + AD + K + ++ T D + DG + + Sbjct: 297 GKGIANPIAMIASFAMCLRYSFNMVKEADDLEKAIANVLDKGIRTGDI--MADGCRQVGT 354 Query: 406 SEFGDAII 413 E G+AI+ Sbjct: 355 VEMGEAIL 362 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 76.3 bits (186), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 86/397 (21%), Positives = 168/397 (42%), Gaps = 64/397 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +++ ++V+ A EK K+++ G + G P ET Sbjct: 5 IAVLAGDGIGPEISVQGVEVMSAVCEKF---GHKVNYEYAICGADAIDKVGDP--FPEET 59 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNV-------ALRQELDLYICLRPVRYYQ----GT 137 + + + + P + V A+R++L L+ +RPV+ ++ + Sbjct: 60 YRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKS 119 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P + E D + RE + +Y G +++ D+ A + R E+ Sbjct: 120 PLRAELVEGADFLCIRELTGGMYFGEKYQ-DNDKAYDTNMYTRPEI-------------- 164 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +R+++ EYA+ R +T+V K N++ + + W Q+A+E Sbjct: 165 ---------ERILKVGFEYAMKR-RKHLTVVDKANVL----ASSRLW-RQIAQE------ 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + P + + D A +Q+ P +DV+ N GD ++D + Sbjct: 204 ------MAPQYPEVTTDYMFVDNAAMKMIQE----PKFFDVMVTENTFGDILTDEGSVIS 253 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G +G+ P A+ G+ +FE HG+ P+ G + NP + ILS M+ + LI Sbjct: 254 GSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYFDCKAEGALIR 313 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 K ++ +++A T + + ++G + E G I++ Sbjct: 314 KAVDASLDANVRTPEIQ--VEGGEKFGTKEVGAWIVD 348 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 74.7 bits (182), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 95/363 (26%), Positives = 148/363 (40%), Gaps = 56/363 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME------IYTGEKSTQVYGQDV 82 I I DG+G DV P K + A E E + E + TG+ G+D+ Sbjct: 6 IAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYEAGVEYAVKTGKMCEDNLGEDI 65 Query: 83 WLPAETL-DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 L Y + G++ L LR + I LRP+R +G P+ Sbjct: 66 AKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQF-LRSGMGNSIGLRPLRLRKGIDCPL 124 Query: 142 KHPELTDMVIFRENSEDIY--AGIEWKADSA-DAEKVIKFLREEMGVKKIRFPEHCGIGI 198 ++ E D+++ R+ +E Y G D+A D V + + E +F + C Sbjct: 125 RNREEIDVLLVRQLAEGFYIRPGHMIGEDAAYDTIVVTRNVTE-------KFADTC---- 173 Query: 199 KPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHK-GNIMKFTEGAFKDWGYQLAREEFGGE 256 RL R + D + VTL +K GN+ F D+ ++ E G Sbjct: 174 --------FRLARG--RHGRRQDGKKMVTLGNKHGNVTCF------DFYRKIFTEVSAGY 217 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 P+ G + D +A+ ++ P +DVIAC N+ GD I D A Sbjct: 218 ------------PDIGLQFTQVDALAEHLIKD----PDRFDVIACENMIGDIIGDIGAYI 261 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG+GI P A++G F HGT P+ G+ NP + IL+A ++L +G D + Sbjct: 262 TGGMGITPTADVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTLGNERGDDNL 321 Query: 377 VKG 379 +G Sbjct: 322 RRG 324 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 74.3 bits (181), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 85/391 (21%), Positives = 163/391 (41%), Gaps = 70/391 (17%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 93 GDGIG ++ ++K+V + + YK I+ + Y G S + + + +I+ Sbjct: 9 GDGIGPEIIKQVIKIVKSCIYTGYK----INIIYNYIGGISIDKFNTPI--TNNLISIIK 62 Query: 94 EYRVAIKG---------PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 G + P G ++ LR++ + + +RP++ P K+ Sbjct: 63 YIDTIFLGCVGGYKWNHSIFKPEYGLLK-----LRKKFNFFTNIRPIK------CPFKN- 110 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D++I RE + IY G ++++I + P K +E+ Sbjct: 111 --IDIIIVRELNGGIYYG----KPKGFSKQIIN-----------QIPTWYAYNTKIYNEQ 153 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR-EEFGGELIDGGPW 263 RL R + A+ N + + + K N+++ FK W + +F + Sbjct: 154 EIIRLARISFNLAL-NRKKKLCSIDKSNVLE----TFKLWKKTINYVHKF---------Y 199 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 KVK + + D+I + ++DVI NL GD ISD + G +G+ Sbjct: 200 NKVKLSHIYIDYATIDLIKNF---------NKFDVIITSNLFGDIISDLCSLLTGSLGML 250 Query: 324 PGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGME 381 P +I ++ +LFE HG+AP A ++ NP +LS MM + + + ++ + + Sbjct: 251 PSISINNKSLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYVLNDFKLSNNLYYSIY 310 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 ++ T D ++ + K++ EFGD + Sbjct: 311 KVLSYGFCTIDMKKYIRNFKIVSTEEFGDLV 341 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 73.6 bits (179), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 99/410 (24%), Positives = 174/410 (42%), Gaps = 78/410 (19%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD-VWLPAETLD 90 + GDGIG +V + +++D + + I+ E G Y D V + T+ Sbjct: 9 LPGDGIGTEVMAEVSRLID------WLNKAGIASFETEHGLVGGAAYDADKVAITDATMA 62 Query: 91 LIREYRVAIKGPL-----------TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP- 138 L + I G + P G +R LR++L L+ LRP Y Sbjct: 63 LAQASDAVIFGAVGGPKWDAVPYDARPEAGLLR-----LRKDLALFANLRPAVCYPALAE 117 Query: 139 -SPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 S +K PE+ D++I RE + +Y G E + + + Sbjct: 118 ASSLK-PEVVEGLDIMIVRELTGGVYFG------------------EPKTITDLGNGQKR 158 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 I + +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 159 AIDTQVYDTYEIERIGRVAFDLA-RKRRNKVTSMEKRNVMK-TGVLWNEVITQVHAREY- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 K++ ++ +AD+ ++ P ++DVI NL GD +SD A Sbjct: 216 ------------------KDVQLEHQLADSGGMNLVKWPKQFDVIVTDNLFGDMLSDIAA 257 Query: 315 AQVGGIGIAPGANIG--DEC-----ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH- 366 G +G+ P A++G D+ A++E HG+AP AG+ NP +++ S M LR+ Sbjct: 258 MLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGLANPVAMLASFGMALRYS 317 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E AD + + + + T D + +G+ ++ S+ G+AI++ M Sbjct: 318 LDMGELADKLDEAIAVVLARGLRTADIKS--EGSTVVSTSQMGEAIVQEM 365 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 72.0 bits (175), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 46/131 (35%), Positives = 73/131 (55%), Gaps = 12/131 (9%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 93 G G+G +++ A+ + +AA + I W E + + + GQD+ + A+ LD +R Sbjct: 39 GHGVGPEISVAVQNIFNAA-------DVPIVWDEHHIDVDNAKP-GQDL-ISADALDSLR 89 Query: 94 EYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 153 R +KGP+ TP+G G RSLN+ LR+ L LY +RP G +P + D+V R Sbjct: 90 RNRFGLKGPMATPIGKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---DDVDVVTVR 146 Query: 154 ENSEDIYAGIE 164 EN+E Y+G+E Sbjct: 147 ENTEGEYSGLE 157 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 70.9 bits (172), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 69/312 (22%), Positives = 133/312 (42%), Gaps = 52/312 (16%) Query: 116 VALRQELDLYICLRPVRYYQGTP--SPVKHPELT--DMVIFRENSEDIYAGIEWKADSAD 171 + +R+++ L+ LRP + S +K ++ D++I RE + +Y G Sbjct: 94 LGIRKDMGLFANLRPATVLEALADASTLKAEVVSGLDIMILRELTGGLYFG--------- 144 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 231 + G+ + G + +R+ R A + A ++ + V K Sbjct: 145 ---------QPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFDLARKRNKKLCS-VDKA 194 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILL 291 N+++ T +++ +L +EEF ++ + + D Q++ Sbjct: 195 NVLECTV-LWREEMIKLQKEEF-------------------PDVELTHMYVDNAAMQLVR 234 Query: 292 RPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD------ECALFEATHGTAPKY 345 P ++DV+ N+ GD +SD A G +G+ P A++G+ AL+E HG+AP Sbjct: 235 NPKQFDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDI 294 Query: 346 AGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK 404 AG+D NP + I+S M LR+ ADLI ++ + T D + G + Sbjct: 295 AGKDMANPLATIMSFAMCLRYSFDMAAEADLIETAVKNVLKGGLRTADI--MQPGKAKVS 352 Query: 405 CSEFGDAIIENM 416 + G+A++ + Sbjct: 353 TTVMGEAVVREL 364 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 70.5 bits (171), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 98/414 (23%), Positives = 161/414 (38%), Gaps = 87/414 (21%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GD +G ++T +KV+ A + + K + G + G V LP E Sbjct: 7 IVVLPGDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--VPLPDEA 62 Query: 89 LDLIREYRVAIKGPLTTPV--GGGIRSLN--VALRQELDLYICLRPVRYYQGT---PSPV 141 L+ ++ + G + P G +R + +R+EL LY LRP + + SP+ Sbjct: 63 LEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPI 122 Query: 142 KHPEL---TDMVIFRE---------NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 K P+ TD V+ RE ED G+ W ++ +V + R + Sbjct: 123 K-PQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQH 181 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 P + + + RL R +E I N+ ++ + H Sbjct: 182 EPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQH-------------------- 221 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 +LID + VKNP I+I N+ GD I Sbjct: 222 ------QLIDSAAMILVKNPTHLNGIII-----------------------TSNMFGDII 252 Query: 310 SDALAAQVGGIGIAPGANIGD------ECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363 SD + G +G+ P A++ L+E HG+AP ++KVNP + ILSA MM Sbjct: 253 SDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLP-KNKVNPIATILSAAMM 311 Query: 364 LR-HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L+ + E I ++ ++A T D + G+ +E GDA+ E + Sbjct: 312 LKLSLNLPEEGKAIEDAVKKVLDAGIRTGD----LGGSN--STTEVGDAVAEEV 359 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 69.7 bits (169), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 75/307 (24%), Positives = 134/307 (43%), Gaps = 48/307 (15%) Query: 112 RSLNVALRQELDLYICLRPVRYYQGTP--SPVKHP---ELTDMVIFRENSEDIYAGIEWK 166 R + LR+ + + RPV +G SP+K E D++I RE +Y G + Sbjct: 94 RGALLPLRRRYNTFANFRPVYLPKGLAHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEM 153 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 +AD ++ F+RE + E+ +++V+ E ++ + + Sbjct: 154 GVNADGKR---FVRE----------------VLEYDEDQIRQIVKVGFEVSMKRKK-VMH 193 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 +HK N++K + W ++ EE E+ +K+++ DA Sbjct: 194 NIHKSNVLKSS----VLWN-EIVEEE----------------SKNYPEVEVKNILVDAAA 232 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 + L P +DV+ N+ GD +SD +G +G+ P A G + + +E +HG+AP A Sbjct: 233 TYLCLNPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSYYEPSHGSAPDIA 292 Query: 347 GQDKVNPGSIILSAEMMLR-HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 G+ NP S+I S +ML G + A + M+ T D + + A L+ Sbjct: 293 GKGIANPYSMIGSVALMLEMSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGE-ANLVST 351 Query: 406 SEFGDAI 412 +EFGD + Sbjct: 352 AEFGDLV 358 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 68.6 bits (166), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 84/355 (23%), Positives = 142/355 (40%), Gaps = 71/355 (20%) Query: 25 ENPIIPYIEGDGIG---VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG----EKSTQV 77 E ++ + G+G+G +DV ++L+++ A G+R E+ TG ++ ++ Sbjct: 26 EAFLVGVLPGEGVGPEVIDVALSLLRLLGEAT-----GQR----FEVRTGGPIGRQAERL 76 Query: 78 YGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG- 136 G+ L E D + L P GG LR+ DLY L P+R++ Sbjct: 77 TGRG--LTPEVRDFCAQVFAQGGAVLCGPGGG---RFVYDLRRHFDLYCKLIPLRHWPAL 131 Query: 137 TPSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 + V PE D++I REN+ +Y G EW ++ A R V + R E Sbjct: 132 ADAGVLRPEAARSADVLIVRENASGLYCG-EWGSEGEGAA------RSAYQVCRYRADE- 183 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 +R++R A+ A D V + G + + Sbjct: 184 ------------VERILRTALRLAGQRRGDLVVVTKPGGVPAISA--------------- 216 Query: 254 GGELIDGGPWLKVKNPNTGKE--IVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 W G+ + + + D Q++ P ++DVI C N+ GD + D Sbjct: 217 --------LWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGD 268 Query: 312 ALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + +G G++ N G A+++ HG A AG+D+ NP + S MMLR Sbjct: 269 CGSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLR 323 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 68.2 bits (165), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 97/410 (23%), Positives = 160/410 (39%), Gaps = 71/410 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GD IG ++ +KV+ + ++ + G S +G V + Sbjct: 7 ILVLPGDHIGPEIMAEAIKVLTTI--ETHRPNLHFNLTTDLVGGTSIDTHG--VPITQSV 62 Query: 89 LDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGT---PSPV 141 LD + + G + P G+ S + LRQ LD + LRP + + SP+ Sbjct: 63 LDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASPI 122 Query: 142 KHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + + T ++ REN Y G E K + A + + R E+ Sbjct: 123 REHVVKGTRFIVVRENCGGAYFG-EKKEEEDVASDLWVYTRPEI---------------- 165 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG---AFKDWGYQLAREEFGGE 256 +RL R + A IM +E A W A G Sbjct: 166 -------ERLARVSAAVA--------------RIMGRSEDDNQAATVWSADKANVLASGR 204 Query: 257 LIDGGPWLKVKNPNTGKE---IVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDA 312 L W ++ + KE I ++ +AD+ ++ P ++ VI N GD +SD Sbjct: 205 L-----WRRITSDIFAKEFPDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTFGDILSDI 259 Query: 313 LAAQVGGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 A G +G+ P A++ ++E HG+AP +G+ NP + ILS MMLR Sbjct: 260 SGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQILSVAMMLR 319 Query: 366 H-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 + MG + A + + + ++AK+ R D CS+ GDA+ E Sbjct: 320 YSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCE 369 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 67.8 bits (164), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 117/299 (39%), Gaps = 73/299 (24%) Query: 118 LRQELDLYICLRPVRYYQGT---PSPVKHPEL--TDMVIFRENSEDIYAGIEWKAD-SAD 171 LR+EL Y LRP + + SP+K TD ++ RE + IY G + D S Sbjct: 97 LRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSGY 156 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE---------GTKRLVRAAIEYAIANDR 222 A + R E+ V+ R + P ++ T RL R + I+ + Sbjct: 157 ACDTEPYSRAEI-VRIARLAGFLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEF 215 Query: 223 DSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIA 282 + L H +LID L VKNP +VI Sbjct: 216 PQLQLEH--------------------------QLIDSAAMLLVKNPRALNGVVITS--- 246 Query: 283 DAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD------EC-ALF 335 NL GD ISD + G IG+ P A++G +C ++ Sbjct: 247 --------------------NLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIY 286 Query: 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 E HG+AP +G+ VNP ILS MMLR+ + + AD + ++ AI+ T T D Sbjct: 287 EPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDL 345 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 66.6 bits (161), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 92/234 (39%), Gaps = 51/234 (21%) Query: 125 YICLR------PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 Y+ LR P R + G SP+ D VI RENSE YAG Sbjct: 84 YLPLRSSTSNMPTRVFHGIQSPLH----LDWVIVRENSEGEYAG---------------- 123 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 G P I + G +R+++ A E A + + +T+ K N + Sbjct: 124 ---HGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAARSRAKKHITVATKSNAQR--- 177 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 W ++A E + D + ++ DA +++L P D Sbjct: 178 NGLVVWD-EIAAAEVAAQFPD---------------VTCDKMLVDAMTARVVLTPESLDT 221 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIG---DECALFEATHGTAPKYAGQD 349 I NL+ +SD +A G IGIAP +N+ + ++FE HG+A AG+D Sbjct: 222 IVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKD 275 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 66.2 bits (160), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 88/342 (25%), Positives = 131/342 (38%), Gaps = 67/342 (19%) Query: 92 IREYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQG-TP-SPVKHPELTD 148 +R IK TP G + S N LR+E+D + +R R G TP + V +P Sbjct: 63 MRTCGFGIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIAGVHYP---- 118 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 + I R ED Y +W+ A A + + E + T+ Sbjct: 119 ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHV----------------------TRS 156 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 RA EYA R V+ G W E E +D ++ Sbjct: 157 TCRAVSEYAFRTARAMQARVYGG----------PKWTVSPVYEGMLKEEMDAA---AARH 203 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG------I 322 P+ E V+ D + P V+ +N +GD +SD + G I + Sbjct: 204 PDVAYEPVLIDATYAGLVSGAADEPL---VVPALNRDGDCLSDLVLPMFGSIAGAESVLL 260 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 A N A+ EA HGTAP G+D NP +++L++ +LRH AA+ +G G Sbjct: 261 AFDDNYETHVAMAEAPHGTAPALRGKDVANPMAMLLASGAVLRH-----AAE---RGHPG 312 Query: 383 AINAKTVTYD--FERLMDGAKL------LKCSEFGDAIIENM 416 A A Y+ E + G K +EF DA+IE + Sbjct: 313 AERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDAVIERI 354 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 110/275 (40%), Gaps = 60/275 (21%) Query: 118 LRQELDLYICLRPVRYYQGT---PSPVKHPELT---DMVIFRENSEDIYAGIEWKADSAD 171 LRQ LD + +RP R+Y + SP+K PE+ D V+ REN Y G Sbjct: 98 LRQRLDAFANIRPCRFYASSLLNQSPLK-PEIAAGVDFVLVRENCGGAYFG--------- 147 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 231 K F + ++ C+ + L R +D+ + + Sbjct: 148 --------------TKTEFEDEARTEVERCARV-SAALARTFGRGKNTDDKSPAIVWNAD 192 Query: 232 NIMKFTEGAF-KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQIL 290 G F + + + EF +I + D +AD+ ++ Sbjct: 193 KANVLASGRFWRTVTHDIFEREF-------------------PDIELHDQLADSMAMVMV 233 Query: 291 LRPAEYD-VIACMNLNGDYISDALAAQVGGIGIAPGANI----GDEC---ALFEATHGTA 342 P +++ VI N GD +SD VG +G+ P A++ G E ++EA HG+A Sbjct: 234 KAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSA 293 Query: 343 PKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLI 376 P +G + NP + ILS M+LR+ ADL+ Sbjct: 294 PDISGTGQANPIAQILSLAMLLRYSFSMPRQADLL 328 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 62.4 bits (150), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 93/401 (23%), Positives = 164/401 (40%), Gaps = 68/401 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST---QVYGQDVWLP 85 I + GDGIG + T + K+++ ++K ++ + I T E + + P Sbjct: 7 IAVLPGDGIGPETTRQVYKILNV-IKKQFQ-------INIVTTEHKIGGDAINSEGTPFP 58 Query: 86 AETLDLIREYRV----AIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPV----RYY 134 TL + A+ GP T + G + +ALR+ +L+ LRP+ Sbjct: 59 KSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELK 118 Query: 135 QGTPSPVKH-PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 + +P + P D++ RE + IY G + K S F + V RF Sbjct: 119 ELSPLNINMIPNGIDIIFVRELTGGIYFG-QPKGRSGTGLNEYAF---DTAVYH-RFE-- 171 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 +R+ A + A R V+ + K N++ T +++ LA+ Sbjct: 172 ------------IERIANIAFKLA-QKRRKRVSSIDKANVLH-TSMLWREVVSHLAKNY- 216 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 ++ ++ + D Q++ P+++D+I C NL GD +SD Sbjct: 217 -------------------PDVELEHLYIDNASMQLINNPSKFDIILCPNLFGDILSDEC 257 Query: 314 AAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 A G IG+ P A+I + L+E G+AP A ++ NP + ILS ++ R+ + Sbjct: 258 AMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIAHILSIALLFRYSLKLDH 317 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 A I K + A+ T D + + K + +E GD I Sbjct: 318 IAIKIEKAVSQALMLGYRTIDIAKKHE--KSISTNEMGDII 356 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 60.8 bits (146), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 91/417 (21%), Positives = 157/417 (37%), Gaps = 83/417 (19%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 NGK P + IEG G G V A+ K+ AA+ E + +Y K+ ++ Sbjct: 34 NGKAQRPIR--VTVIEGQGTGPVVLAAVRKIFKAALVPV---EWDYQTLSVYRDHKTNRM 88 Query: 78 YGQDVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + + LD E + + ++P + S ++AL + L+ ++ +R Sbjct: 89 -----TVNPQLLDSAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFN---- 139 Query: 137 TPSPVKHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 S V H ++V RE+ Y+ IE + Sbjct: 140 --SVVGHEPYGPINLVNIREHVSGEYSEIEHLVSPGVVQS-------------------- 177 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK S++ + + + A +YA + +T++HK ++M+ ++G F + RE Sbjct: 178 ---IKTVSKKISVEVAKLAFDYACKHGHSRITVLHKADVMRLSDGIF----LKACRE--- 227 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 + P ++ + D+F + P Y+V+ +L G + Sbjct: 228 ---------VSACYP----DVEYNEEKLDSFCLNVTTNPGRYEVLLTTSLYGAFAGSVCG 274 Query: 315 AQVGGIGIAPGANIGDECALFEA---------TH----GTAPK--YAGQDKVNPGSIILS 359 GG+ P G + +F +H G K Y + +NP II + Sbjct: 275 MMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYGQEQIINPTGIIRA 334 Query: 360 AEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +ML H G A I +E I T D M G CS+F DAII+N+ Sbjct: 335 AALMLDHAGMVVAGRCIAAAVEDTIRQGIRTQD----MGGDA--SCSQFTDAIIKNL 385 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 58.5 bits (140), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 7/81 (8%) Query: 337 ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDFER 395 + HG+APKYAG KVNP +++LS MML+ + EAA I KG++ + AK +TY Sbjct: 3 SVHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKHLTY---- 58 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 D E+ DAII+ M Sbjct: 59 --DAGGTASTDEYADAIIKAM 77 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 57.0 bits (136), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 88/336 (26%), Positives = 136/336 (40%), Gaps = 95/336 (28%) Query: 37 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV-WLPAETLDLIREY 95 I +VT A+ +V+DA Y E Y + G+++ L E +D IR+ Sbjct: 8 IDSNVTNAVHQVMDAMQAPVY--------FETYI------IKGKNMNHLTWEVVDSIRKN 53 Query: 96 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 155 +V + G + + GG R+ELDL+ L G PS +H E D+V+ REN Sbjct: 54 KVCLNGRVNNSLCGG-------ARKELDLFASLVDCFNLNGQPS--RH-ENVDIVVIREN 103 Query: 156 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 215 +E YAG E +V+ + E V +F + R+ + A E Sbjct: 104 TEGEYAGRE--------HEVVPGVIESFQVTMTKF--------------WSDRIAKYAFE 141 Query: 216 YAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN-TGK 273 YA + R VT VH G K + F + ++A+ PN T Sbjct: 142 YAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMY----------------PNITYN 185 Query: 274 EIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI--GIAPGANIGDE 331 EI ++ A + R + S +L A + I G+A G + GD+ Sbjct: 186 EIASRETRA-------IRRHSN--------------SKSLWAIIANIASGVA-GGSFGDD 223 Query: 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 A+FE G K NP +++ S+ MMLRH+ Sbjct: 224 YAIFEQVGSV-----GNHK-NPVALLFSSVMMLRHL 253 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 53.9 bits (128), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 93/381 (24%), Positives = 150/381 (39%), Gaps = 70/381 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V +V++ + E K+ + G S +G+ L A T Sbjct: 8 IVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDF--GGCSIDKHGEP--LTAAT 63 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLN--VALRQELDLYICLRPVRYYQGTP---SP 140 L+ + + G + P V +R +ALR+ L LY +RP + + SP Sbjct: 64 LEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSP 123 Query: 141 VKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 +K P + D+++ RE Y G R+E+G R E Sbjct: 124 LK-PSVARGVDIIVIRELIGGAYFG----------------ERKELGA---RAQEDAAWD 163 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S +R+ R+ + A + V + K N++ + + W ++A E E Sbjct: 164 TMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL----ASSRLW-RKVATETIQNEF 218 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 P LK+ + + D+ I+ P + + VI NL GD +SD + Sbjct: 219 ----PQLKLDHH-----------LVDSASMLIVANPKKLNGVILTENLFGDILSDESSVI 263 Query: 317 VGGIGIAPGANIG-------------DECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363 G +G+ P A++ ++E HG+AP AGQ NP ILSA M+ Sbjct: 264 PGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIANPIGTILSAAML 323 Query: 364 LRHMG-WTEAADLIVKGMEGA 383 W A I +EGA Sbjct: 324 CGTRSVWRSPAKAIEAAVEGA 344 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 62/308 (20%), Positives = 124/308 (40%), Gaps = 55/308 (17%) Query: 112 RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSAD 171 +SL + +LDLY+ + +R + G + P++ D+ + +N+ Y+ +E+ A Sbjct: 133 KSLKIC--NDLDLYVFMTRLRSFPGFK--CRFPDV-DIQVIAQNNIGNYSELEY----AP 183 Query: 172 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 231 + V++ LR + E + +R A E AI R VTL+HK Sbjct: 184 VKGVVEALR-------------------VVTHENVTKYLRHAFEAAIRAGRCRVTLIHKA 224 Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILL 291 N T+GA + ++ E++ I ++ + D + +++ Sbjct: 225 NEWPVTDGAMVEIAEKMHAEDYCS-------------------IKLELMELDDCVNRLIT 265 Query: 292 RPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKV 351 PA +D I + +++ + GG + +GD A+F+ T + Sbjct: 266 DPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGDSHAVFKPLQ-TKLSLTNYSLL 324 Query: 352 NPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFE-------RLMDGAKLLK 404 +P I+ + +L H+G A + KGM + T +F+ + + L+ Sbjct: 325 SPYGIVSTCVDLLNHVGQESCAKSLWKGMLRTMTDGIKTVEFDGPDTGEYVICNIMNKLR 384 Query: 405 CSEFGDAI 412 CS G+ + Sbjct: 385 CSALGENV 392 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 52.4 bits (124), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 10/125 (8%) Query: 297 DVIACMNLNGDYISDALAAQVGGIGIA------PGANIGDEC-ALFEATHGTAPKYAGQD 349 DV+ L GD +SD A + G + PG + C LFE HG+AP+ A +D Sbjct: 220 DVLVTEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRD 279 Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEF 408 +V+P L+ +LRH T A V+ GA+ + TYD + +G + Sbjct: 280 QVDPLGGFLALAALLRHFPATREAGERVRAAVGAVLRSGPWTYDL--VPEGGAAASTGQV 337 Query: 409 GDAII 413 DA++ Sbjct: 338 ADAVL 342 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 50.8 bits (120), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 58/279 (20%), Positives = 115/279 (41%), Gaps = 46/279 (16%) Query: 115 NVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEK 174 ++ L +LDLY+ VR + G + P++ ++ I +N+ +Y+ +E+ Sbjct: 125 SMKLCNDLDLYMFKCRVRSFPGFN--CRFPDV-NIRIIAQNNMGVYSDLEYSP------- 174 Query: 175 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 234 +K + E + V ++EG ++ +R A A+ +R VTL+HK Sbjct: 175 -VKGVVEAISVS---------------TQEGNEKYLRKAFATAVKANRKRVTLIHKSTEW 218 Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 T+GA ++ + D L+++ N ++D I +++ P Sbjct: 219 PITDGAMVSAAKEIHK--------DYEHCLELELMN------VEDCIG-----RLITHPQ 259 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+D I + I+ + GG + IGD A+F+ ++P Sbjct: 260 EFDCIFSSDRYATMIATMCSGICGGANLFSAVEIGDFHAVFKPLQ-VKLSLTNYPILSPY 318 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDF 393 I+ + + H+G+TE D + + M + + T DF Sbjct: 319 GIVNTIVDLFDHLGYTECGDALWEQMLRTMESGIKTKDF 357 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 50.4 bits (119), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 80/361 (22%), Positives = 138/361 (38%), Gaps = 81/361 (22%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI-YTGEKSTQVYGQDVWL 84 P I + GD G ++ L+V+ +V + + + +++ + E + VW Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIR-----QPLQFLDYDLSLENRRATDNKVVW- 58 Query: 85 PAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRP------VRYYQGT 137 E R+ +++K TP + G + S N LR+ L+ + LR +R G Sbjct: 59 --EAAQAARDSGLSLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGV 116 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 SP+ I R +D Y EW+ + + +++ KI Sbjct: 117 YSPI--------AIVRMAVDDAYGSKEWRETTENGDEI------AYRTSKI--------- 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT-----EGAFKDWGYQLAREE 252 ++ RA E+ + + V G KFT EG FK Sbjct: 154 --------SRSTCRAVAEFTFQYAKRTKAKVFGGP--KFTVSATYEGMFK---------- 193 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 E +D + P E+ + ++ DA +L E VI +N +GD +SD Sbjct: 194 ---EELDAA---AKRYP----EVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDM 243 Query: 313 LAAQVGGIGIAPGANIGDEC-------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + G I + +G E + EA HGTAP G++ NP ++IL+ +L Sbjct: 244 VLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLS 303 Query: 366 H 366 + Sbjct: 304 Y 304 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 48.5 bits (114), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 122/309 (39%), Gaps = 42/309 (13%) Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSL--NVALRQELDLYICLRPV 131 +TQ Y V T D R +K +P G IR++ R+ + IC Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSP-NGTIRNILGGTVFREPI---ICKNIP 158 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK---I 188 R G P+ I R D Y ++ AD A K++ ++ GVK+ Sbjct: 159 RLVPGWTKPI--------TIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVY 210 Query: 189 RFPEH-CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247 FP G+G+ ++E + +YAI + + + K I+K +G FKD + Sbjct: 211 NFPAGGVGMGMYN-TDESISGFAHSCFQYAI-QKKWPLYMSTKNTILKAYDGRFKDIFQE 268 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 + + + + W + + +I D++A Q+L + V AC N +GD Sbjct: 269 IFDKHYKTDFDKNKIWYEHR--------LIDDMVA-----QVLKSSGGF-VWACKNYDGD 314 Query: 308 YISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSIILS 359 SD LA G +G+ + + EA HGT ++ + + NP + I + Sbjct: 315 VQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFA 374 Query: 360 AEMMLRHMG 368 L H G Sbjct: 375 WTRGLEHRG 383 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 122/308 (39%), Gaps = 72/308 (23%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 +N P I I GDGIG ++ + ++V+ AA + + ++ + G + + G Sbjct: 1 MNAPHALDIAVIPGDGIGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTGS 56 Query: 81 DVWLPAETLDLIR-EYRVAIKGPLTTPVGGGIRSLN--------VALRQELDLYICLRPV 131 + A TL+ IR Y +KGP+ P G+R + LR LD Y +RP+ Sbjct: 57 --AMSAATLERIRTRYHGVLKGPVGLP---GVRHPDGTEAGLLGGVLRGGLDTYANVRPI 111 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIY--AGIEWKADSADAEKVIKFLREEMGVKKIR 189 G +P++ D VI REN+E +Y G D A A++++ Sbjct: 112 ALLPGVDAPLRG-TAVDYVIVRENTEGLYLSRGRGVGNDRACADQLL------------- 157 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKD 243 + G +R+V A E A A+ VT V K N+++ Sbjct: 158 -----------MTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-------- 198 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 + RE F + + P ++ ADA ++ P +DV+ N Sbjct: 199 -SFAFFREVFD--------EVATRYP----QVEADHRYADAAGHDLVADPGRFDVLVMEN 245 Query: 304 LNGDYISD 311 GD +SD Sbjct: 246 FLGDILSD 253 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 45.4 bits (106), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%) Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++++FR + G+E++++S + ++K E+G ++I PE +GI+ + + Sbjct: 102 NVLLFRYELDMSDTGMEFESNSGEQLALVKTA-AELGPREI--PEQAALGIQAIAPDRVS 158 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 VR A+ D D + + HKGN +K T+G F Sbjct: 159 EFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLF 192 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 43.5 bits (101), Expect = 0.014, Method: Compositional matrix adjust. Identities = 79/383 (20%), Positives = 140/383 (36%), Gaps = 82/383 (21%) Query: 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 91 ++GD IG +V +L + D V +++ G + ++ + G Q D + TL Sbjct: 18 LQGDHIGPEVMAEVLPLFD--VIQSHFGIKVETFERLIGGSCLDQ---HDCPIQESTLQE 72 Query: 92 IREYRVAIKGPLTTP---VGGGIRSLNVA---LRQELDLYICLRPVRYY---QGTPSPVK 142 E + G + P VG R +R+ L+LY +RP + Q S +K Sbjct: 73 ASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLK 132 Query: 143 HPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + +++ REN+ IY G + + D A K L G I I + Sbjct: 133 EHVVRGVNIITLRENAGGIYFGRKQEPDPL-AHKAALSLASSHGPLPI-------ISVDK 184 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + T RL R + I ++ + ++ +L+D Sbjct: 185 ANVMATSRLWRQVVTETIRDE------------------------FPQLMDKLSHQLVDS 220 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 L K+P +V+ + NL GD +SD + G + Sbjct: 221 AAMLLAKDPRKLNGVVLTE-----------------------NLFGDILSDLTSVIPGSL 257 Query: 321 GIA----------PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGW 369 G+ P + +++ G+AP AG+ NP + +S +M R +G Sbjct: 258 GVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIANPIGMFMSFGLMCRWSLGL 317 Query: 370 TEAADLIVKGMEGAINAKTVTYD 392 +AAD I ++ + + T D Sbjct: 318 PKAADAIDSAIKDCLESGQCTRD 340 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 42.4 bits (98), Expect = 0.031, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 26/244 (10%) Query: 112 RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD-MVIFRENSEDIYAGIEWKADSA 170 +S N +R LD I P+ + P V P T ++I R D Y +++ D Sbjct: 271 KSPNATIRNTLDGTIFRAPI-LMKNVPRLV--PSWTKPIIIGRHAHADQYKALDFTVDKP 327 Query: 171 DAEKVIKFLREEMGVKKIR-FPEHCGIGIK---PCSEEGTKRLVRAAIEYAIANDRDSVT 226 V+ F+ + ++ E G G+ ++ K + +YA+ + + + Sbjct: 328 -GRFVMSFIPADKSNPEVHEVYEFKGGGVALGMYNTDASIKGFAHSCFQYAL-DQKMPLY 385 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 L K ++K +G FKD + +E+ + + G W + + +I D++A A Sbjct: 386 LSTKNTVLKKYDGRFKDIFQTIYEKEYKQKFEEAGLWYEHR--------LIDDMVAQA-- 435 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPK 344 ++ + V AC N +GD SD +A G +G+ + + EA HGT + Sbjct: 436 ----IKSSGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTR 491 Query: 345 YAGQ 348 + Q Sbjct: 492 HYRQ 495 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 41.6 bits (96), Expect = 0.050, Method: Composition-based stats. Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 6/90 (6%) Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILS 359 N+ GD +SD A G I +AP +I E +LFE HG+ P G+ NP + Sbjct: 3 NVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQMAR 62 Query: 360 ---AEMMLRHMGWTEAADLIVKGMEGAINA 386 M+L H+G+ E I +E +++ Sbjct: 63 FGVGAMILDHLGYPETGKAIFSVIEKVLSS 92 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 40.8 bits (94), Expect = 0.093, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 7/98 (7%) Query: 274 EIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE-- 331 EI ++ ++ D +++ P +DVI N+ GD I+D A G P ++ E Sbjct: 225 EIELEHMLVDHGAFKLVSSPDAFDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERK 284 Query: 332 ---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 C H + AG + NP +IL+A MML + Sbjct: 285 GIYCP--NQLHQVHEELAGTGRANPVGMILAAAMMLEY 320 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 40.8 bits (94), Expect = 0.099, Method: Compositional matrix adjust. Identities = 53/236 (22%), Positives = 96/236 (40%), Gaps = 36/236 (15%) Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 ++E + A++ A + + L K I+K +G FKD ++ + + + G Sbjct: 187 TDESVRSFAEASMNMAF-QKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKSKYEEAG 245 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 W + + +I D++A A L+ V AC N +GD SD LA G +G Sbjct: 246 IWYEHR--------LIDDMVAYA------LKSEGGYVWACKNYDGDVQSDFLAQGFGSLG 291 Query: 322 IAPGANIGDECALF--EATHGTAPKY------AGQDKVNPGSIILSAEMMLRHMGWTEAA 373 + + + EA HGT ++ G+ N + I + L H + Sbjct: 292 LMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNN 351 Query: 374 DLIVKGME-------GAINAKTVTYDFER-LMDGAKL-----LKCSEFGDAIIENM 416 + ++ E GA+ + +T D ++ G+KL L EF DA+ + + Sbjct: 352 ERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADEL 407 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 528 e-148 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 520 e-146 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 504 e-141 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 475 e-132 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 471 e-131 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 462 e-128 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 454 e-126 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 451 e-125 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 449 e-124 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 445 e-123 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 441 e-122 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 440 e-122 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 428 e-118 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 415 e-114 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 400 e-110 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 398 e-109 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 394 e-108 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 387 e-106 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 384 e-105 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 380 e-104 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 380 e-104 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 379 e-104 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 377 e-103 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 373 e-102 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 368 e-100 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 367 e-100 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 365 2e-99 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 365 2e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 364 3e-99 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 363 9e-99 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 362 1e-98 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 362 1e-98 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 358 2e-97 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 357 3e-97 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 357 4e-97 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 355 2e-96 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 352 2e-95 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 350 6e-95 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 349 1e-94 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 345 1e-93 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 345 2e-93 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 342 1e-92 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 341 3e-92 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 341 3e-92 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 340 7e-92 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 339 1e-91 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 339 1e-91 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 338 2e-91 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 338 2e-91 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 4e-91 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 337 4e-91 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 337 5e-91 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 337 5e-91 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 6e-91 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 7e-91 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 335 2e-90 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 335 2e-90 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 333 5e-90 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 333 6e-90 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 332 1e-89 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 332 1e-89 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 332 2e-89 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 331 2e-89 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 331 3e-89 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 330 8e-89 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 328 3e-88 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 327 5e-88 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 326 8e-88 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 326 1e-87 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 325 2e-87 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 325 2e-87 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 323 1e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 321 2e-86 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 321 3e-86 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 320 7e-86 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 319 1e-85 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 319 1e-85 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 318 2e-85 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 318 2e-85 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 317 4e-85 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 317 5e-85 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 316 7e-85 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 316 1e-84 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 315 3e-84 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 314 4e-84 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 314 5e-84 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 313 6e-84 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 313 1e-83 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 312 2e-83 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 311 2e-83 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 311 3e-83 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 310 6e-83 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 309 1e-82 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 309 1e-82 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 308 3e-82 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 306 7e-82 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 306 9e-82 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 306 1e-81 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 306 1e-81 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 306 1e-81 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 305 2e-81 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 305 2e-81 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 305 2e-81 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 304 3e-81 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 304 4e-81 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 301 2e-80 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 300 5e-80 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 298 2e-79 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 298 2e-79 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 298 3e-79 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 297 5e-79 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 296 8e-79 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 295 2e-78 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 295 2e-78 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 291 3e-77 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 290 5e-77 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 290 6e-77 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 288 2e-76 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 288 3e-76 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 288 3e-76 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 288 3e-76 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 288 4e-76 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 286 1e-75 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 285 2e-75 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 285 3e-75 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 284 3e-75 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 284 4e-75 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 284 5e-75 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 282 1e-74 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 282 2e-74 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 279 2e-73 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 279 2e-73 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 273 7e-72 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 272 2e-71 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 270 7e-71 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 269 1e-70 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 268 2e-70 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 268 3e-70 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 267 5e-70 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 266 9e-70 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 265 2e-69 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 264 3e-69 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 264 6e-69 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 261 3e-68 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 258 3e-67 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 257 5e-67 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 256 9e-67 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 254 4e-66 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 253 9e-66 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 253 1e-65 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 250 6e-65 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 243 1e-62 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 239 2e-61 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 238 4e-61 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 222 2e-56 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 217 7e-55 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 212 1e-53 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 210 7e-53 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 199 1e-49 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 191 3e-47 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 190 7e-47 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 190 7e-47 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 186 1e-45 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 185 2e-45 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 182 2e-44 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 179 1e-43 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 175 2e-42 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 168 3e-40 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 159 2e-37 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 157 7e-37 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 145 2e-33 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 88 6e-16 Sequences not found previously or not previously below threshold: UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 228 3e-58 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 202 1e-50 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 185 2e-45 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 158 4e-37 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 133 1e-29 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 128 4e-28 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 125 3e-27 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 125 4e-27 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 118 5e-25 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 108 3e-22 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 108 4e-22 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 103 9e-21 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 102 4e-20 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 98 7e-19 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 95 6e-18 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 93 2e-17 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 90 1e-16 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 90 2e-16 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 89 2e-16 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 85 6e-15 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 80 2e-13 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 78 5e-13 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 78 7e-13 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 78 7e-13 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 75 4e-12 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 74 8e-12 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 74 9e-12 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 72 3e-11 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 70 1e-10 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 70 1e-10 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 70 2e-10 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 70 2e-10 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 68 8e-10 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 68 8e-10 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 66 3e-09 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 66 3e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 62 5e-08 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 62 5e-08 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 61 8e-08 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 60 2e-07 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 57 2e-06 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 55 3e-06 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 54 8e-06 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 54 9e-06 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 54 1e-05 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 53 3e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 7e-05 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 51 9e-05 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 50 1e-04 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 48 7e-04 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 48 8e-04 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 47 0.001 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 46 0.003 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 45 0.005 UniRef50_P41566 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 42 0.035 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 42 0.058 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 327/416 (78%), Positives = 370/416 (88%), Gaps = 1/416 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + L+VP+NPIIP+IEGDGIGVD++P M+KVVDAAVEKAYKGE Sbjct: 3 YQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+C RPVR+++G PSPVK P DMVIFRENSEDIYAG+EWKA S +AEKVIKFL Sbjct: 123 QLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLT 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++YA+ NDR SVTLVHKGNIMKFTEGA Sbjct: 183 EEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGA 242 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY++AR+EFG EL+DGGPW++ KNP TGK +V+KDVIADA LQQILLRPAEYDVIA Sbjct: 243 FKDWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIA 302 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAA+VGGIGIAPGAN+ D A+FEATHGTAPKYAGQDKVNPGS+ILSA Sbjct: 303 TLNLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSA 362 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGWTEAADLI+KG GAI AKTVTYDFERLMDGA LL CSEFGDA+I M Sbjct: 363 EMMLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 520 bits (1340), Expect = e-146, Method: Composition-based stats. Identities = 307/416 (73%), Positives = 360/416 (86%), Gaps = 1/416 (0%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+ Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAAQVGGIGIAPGAN+GDE A+FEATHGTAPKYAG++KVNPGS+ILSA Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 291/419 (69%), Positives = 348/419 (83%), Gaps = 8/419 (1%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+ Sbjct: 8 LQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query: 65 WMEIYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA 117 W E++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVA Sbjct: 68 WYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 LRQ++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I Sbjct: 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 FL+ E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+T Sbjct: 187 FLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query: 238 EGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 EGAF WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY Sbjct: 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYS 306 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSII 357 VIA MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSII Sbjct: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LSAEMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM Sbjct: 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 475 bits (1223), Expect = e-132, Method: Composition-based stats. Identities = 260/422 (61%), Positives = 313/422 (74%), Gaps = 17/422 (4%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 +KIT LNVP PIIP+I GDGIG D+ A +V+DAAVEKAY GE++I W E+ Sbjct: 2 TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVL 61 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 G+K+ G+ WLP ETLD I+EY +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLR Sbjct: 62 AGQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLR 119 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PVR+++G PSPVK P+ DMVIFREN+EDIYAGIE+K + + +KVI FL+ EMG IR Sbjct: 120 PVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIR 179 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 FPE GIGIKP S+EGT+RLVRAAI+YAI N+R SVTLVHKGNIMKFTEG+FK WGY LA Sbjct: 180 FPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239 Query: 250 REEFGGELIDGGPW-------------LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 EFG ++ + + + +I+IKD IAD FLQQIL RPAE+ Sbjct: 240 LTEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEH 299 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIG--DECALFEATHGTAPKYAGQDKVNPG 354 DV+A MNLNGDYISDALAAQVGGIGIAPGANI A+FEATHGTAPKYAG +KVNP Sbjct: 300 DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPS 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 S+ILS+ +ML H+GW EAAD I +E I +K VTYDF RLMDGA+ + S F D +I+ Sbjct: 360 SVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIK 419 Query: 415 NM 416 N+ Sbjct: 420 NL 421 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 471 bits (1211), Expect = e-131, Method: Composition-based stats. Identities = 221/422 (52%), Positives = 292/422 (69%), Gaps = 10/422 (2%) Query: 2 ESKVVVPAQGKKITLQNG---KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 K+ VP G+KITL+ G ++ VP+NPIIP I GDGIG DV PA KV++AA E Sbjct: 3 YDKIEVPDAGEKITLKEGSEDEIEVPDNPIIPIIHGDGIGKDVGPAAQKVLEAAAE---A 59 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R ISWM +Y GE + + YG+DV LP ET+D IRE+RVAIKGPLTTPVG G RSLNVAL Sbjct: 60 TGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LDLY +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + +EMG + GIG+KP +E+G+KRLVR AI+YA+ +DRD VTLVHKGNIMKFTE Sbjct: 180 VEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F DWG ++A EE+ + + P W + ++ +++++ +ADA LQ + LR Sbjct: 240 GQFGDWGMEVADEEYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+D++A NLNGDY+SDA AQ+GG+GIAPG N G L E HG+APK AGQD NP Sbjct: 300 EFDILAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGKGRMLAEPVHGSAPKRAGQDMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M ++GW +AADLI +E I++ VTYD ER ++ A+ L SE+ D I++ Sbjct: 360 AMILSGRLMFDYLGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVD 419 Query: 415 NM 416 + Sbjct: 420 TI 421 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 235/472 (49%), Positives = 305/472 (64%), Gaps = 56/472 (11%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G+KIT QNG+ VP+NPI+P+I GDG G+D+ PA KV+DAAV KAY G+ Sbjct: 1 MYEKITPPSTGEKITFQNGEPIVPDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGK 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISW ++Y G+++ +YG +LP +TL I+EY +AIKGPLTTP+GGGIRSLNVALRQ Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K P+ D++++REN+EDIY GIEWK S E++I L Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILN 180 Query: 181 EEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 +++ K + P GIGIKP S G++RLVR A+++A+ ++ VTLVHKGNI Sbjct: 181 KDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MK+TEGAF+DWGY+LA +EF E + Sbjct: 241 MKYTEGAFRDWGYELATQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTP 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W + ++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKKAQIVKEVETVINSIWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD CA+FEATHGTAPK+AG DK+NPGS+ILS MML Sbjct: 361 GDYLSDAAAAIVGGLGMGPGANIGDSCAIFEATHGTAPKHAGLDKINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMD-GAKLLKCSEFGDAIIENM 416 +MGW EAADLI +G+ +I VTYD RLM+ + LKCSEF D II+ Sbjct: 421 YMGWQEAADLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQF 472 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 454 bits (1168), Expect = e-126, Method: Composition-based stats. Identities = 207/416 (49%), Positives = 296/416 (71%), Gaps = 3/416 (0%) Query: 2 ESKVVVPAQGKKITL-QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 + VP QG+ I + +NG+ +P PII YI+GDG+G DV P M KVVD+A+ Y+ + Sbjct: 6 YQHINVPEQGQSIKIAKNGQWQIPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAK 65 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI WM++Y GE++ ++Y D W P ET++ +RE ++AIKGPLTTP+GGG RSLNVALRQ Sbjct: 66 RKIHWMQVYNGEQAAKLYDGD-WFPQETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQ 124 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 E+DL++ +R ++ + PSP+K+P LT++ + R++SED+Y+GIEW+A S ++EKV+ FL Sbjct: 125 EMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLC 184 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGV ++RF + CGIGIK S+EG++RLVR AI YA+ N+ +S+TLVHKGN++KFT+GA Sbjct: 185 EEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGA 244 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK WG+ LA+ E+ + G WL + ++IK+VIAD LQQ L+ P ++DV+A Sbjct: 245 FKRWGFALAKREYQAIDDENGRWLHIPR-QGQPPLIIKEVIADNMLQQCLMHPEQFDVVA 303 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 N NGD+++D L+AQVGG+GI P AN+ +E A FE THGT + AGQ+K NP S ILSA Sbjct: 304 TTNQNGDFLADMLSAQVGGVGIMPAANLNNEVAFFEPTHGTFARIAGQNKANPSSSILSA 363 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +ML+ M W EAA+LI +E + A VT+D + L C++F +IE+ Sbjct: 364 VLMLKFMQWHEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEHF 419 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 451 bits (1159), Expect = e-125, Method: Composition-based stats. Identities = 197/421 (46%), Positives = 274/421 (65%), Gaps = 13/421 (3%) Query: 2 ESKVVVPAQGKKITLQN-GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K + P G+ + G+L VP+ +I YIEGDGIG +V A +KV + AVEKAY Sbjct: 19 TGKYIDPPSGEYVKYTGPGQLKVPDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKS 78 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 R+I+W EI GEK+ +++G LP ++++++R+ RV +K PL TPVGGG RS+NV LRQ Sbjct: 79 RQITWYEIVVGEKAEKLFGNR--LPDQSIEVLRKIRVFLKAPLETPVGGGFRSINVTLRQ 136 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ED+YAGIEW +S +A K+ +FLR Sbjct: 137 LFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLR 196 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 E GV + GIGIKP S+ GT+R+ R A+++AI N R VT++HKGNI K+TEGA Sbjct: 197 REFGV---NIRDDAGIGIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGA 253 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK+W +++AR EF ++ + ++++ D IAD LQQ+L R EYDVI Sbjct: 254 FKEWAFEVARNEFREHVVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVIL 313 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A VGG+G+APG ++GD + E HGTAPKY G++ VNP + IL+ Sbjct: 314 APNLNGDYVSDEAAGLVGGLGVAPGLDVGDWGMMAEPVHGTAPKYRGKNYVNPTATILAL 373 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDF-------ERLMDGAKLLKCSEFGDAII 413 E+M R +GW E A+ I+KG+E A T D ER M ++L EF D ++ Sbjct: 374 ELMFRFLGWREVAEYIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVV 433 Query: 414 E 414 E Sbjct: 434 E 434 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 217/422 (51%), Positives = 290/422 (68%), Gaps = 12/422 (2%) Query: 2 ESKVVVPAQGKKITL---QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 KV VPA+G+KI + N +L++PENPI+P I GDGIG DV PA KV++AA A Sbjct: 5 YDKVEVPAEGEKIEVVDEDNDELDIPENPIVPIIHGDGIGKDVGPAAQKVLEAA---ANA 61 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R+ISWM ++ GE + + Y ++ LP +T++ I E+RVAIKGPLTTPVG G RSLNVAL Sbjct: 62 TGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LD Y +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + E+MG + GIGIKP +E G+KRLVR AI+YAI +DRD VTLV KGNIMKFTE Sbjct: 180 VEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F +WG ++A EE+ + + P W + ++ ++++ +ADA LQ + LR Sbjct: 240 GQFTEWGMEVADEEYPDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+ V+A NLNGDY+SDA AQ+GG+GIAPGAN GD L E HG+APK AGQ+ NP Sbjct: 300 EFSVLAMPNLNGDYLSDAAGAQIGGLGIAPGANFGDARVLAEPVHGSAPKRAGQNMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M +MGW +AADL+ +E I++ TVTYD ER ++ A+ L E+ DAI+E Sbjct: 360 AMILSGRLMFDYMGWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVE 419 Query: 415 NM 416 N+ Sbjct: 420 NI 421 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 445 bits (1145), Expect = e-123, Method: Composition-based stats. Identities = 233/473 (49%), Positives = 294/473 (62%), Gaps = 57/473 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180 Query: 181 EEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA--NDRDSVTLVHKGNI 233 +E+ + K + GIGIKP S+ G++RLVR AI +A + VTLVHKGNI Sbjct: 181 DELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MKFTEG F+DWGY+LA EF E + Sbjct: 241 MKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTE 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W N +++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD A+FEATHGTAPK+AG D++NPGS+ILS MML Sbjct: 361 GDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMD--GAKLLKCSEFGDAIIENM 416 MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ + Sbjct: 421 FMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSHF 473 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 441 bits (1134), Expect = e-122, Method: Composition-based stats. Identities = 212/417 (50%), Positives = 283/417 (67%), Gaps = 17/417 (4%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 +K+T+ NG+L VP NP IP+IEGDGIG ++ A V DAAV+KAY G+++++W+ + G Sbjct: 4 EKVTMNNGQLQVPNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAG 63 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131 E + + GQ WLP +TL +REY V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV Sbjct: 64 ETAYKKTGQ--WLPDKTLATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPV 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 YY GTPSPV HPE ++ +FREN+EDIYAGIE D+ DAE+ L ++ + K+RFP Sbjct: 122 TYYPGTPSPVVHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFP 181 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + IKP S++G+ RLV AAI+YA AN+R ++TLVHKGNIMK TEG FK WGY+ A + Sbjct: 182 DTSAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEK 241 Query: 252 E------------FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 + + + +++++ DVI D F QQ LL P ++V+ Sbjct: 242 YGDKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVV 301 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIG--DECALFEATHGTAPKYAGQDKVNPGSII 357 A MNLNGDYISDALAAQVGGIGIAPG NI A+FEATHGTAP++AGQ+K+NP SII Sbjct: 302 ATMNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSII 361 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 LS MM ++GW + ++LI G++ AI + VT DF + D A +L S FG+ + + Sbjct: 362 LSGAMMFDYLGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPD-ATVLSTSGFGEYVAQ 417 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 440 bits (1132), Expect = e-122, Method: Composition-based stats. Identities = 197/417 (47%), Positives = 266/417 (63%), Gaps = 10/417 (2%) Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 + P++G+ +NGKL VP+N I+ Y +GDGIG ++ + KV+DAAV+KAY G R+ Sbjct: 9 DEAKPPSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRR 68 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I W E+ GE++ + G LP TL + RV +KGPLTTPVGGG RSLNV LR L Sbjct: 69 IVWWEVTAGEEAQKECGS--LLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVL 126 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY +RPV++Y G P+P HPE D VIFREN+ED+YAGIEW DS +A+K+ FL++E Sbjct: 127 DLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKE 185 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 G++ GIGIKP S+ T+R VR A+E+AI N VT++HKGNIMK+TEGAF+ Sbjct: 186 FGIE---LTPDTGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFR 242 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKE--IVIKDVIADAFLQQILLRPAEYDVIA 300 W Y L EF ++ + K E I++ D IAD LQQI+ RP EY+VI Sbjct: 243 QWAYDLILSEFRDYVVTEEE-VNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIV 301 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDYISD A VGGIG+A G ++GD A+ E HG+APKYAG++ +NP + ILS Sbjct: 302 TPNLNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSG 361 Query: 361 EMML-RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +L +GW E L+ ++ AI K VTYD R M G + +E+ D +++ + Sbjct: 362 MYLLSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 186/420 (44%), Positives = 265/420 (63%), Gaps = 12/420 (2%) Query: 2 ESKVVVPAQGKKITLQNGK-LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 E K +P +G+ I L+ K L VP+NPIIP+IEGDGIG ++T AML +++ AVEK Y G Sbjct: 13 EGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGS 72 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +KI W+E+ G+K+ + G+ LP ETLD+++E V IKGPL TPVG G+RS+N ALR+ Sbjct: 73 KKIYWVELLAGDKAEEKTGER--LPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRR 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 D Y +RPV Y+ G +P+ +PE D+V+FREN++D+YAG+E+ A + +A+KV +FL Sbjct: 131 AFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLI 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 +EMG K+ FPE GI +KP SE TKR VR A+ YA+ N++ +V ++ KGNIMK TEGA Sbjct: 190 KEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGA 249 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F +W +++A E G + ++ + VI D L Q++L+P +DVI Sbjct: 250 FINWAFEVAEE----PEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVII 305 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A+ +GG G P NIGD ALFE+THGTA AG+ NP S+ LS Sbjct: 306 AQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSG 365 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDF----ERLMDGAKLLKCSEFGDAIIENM 416 MML ++GW EAA + + + T D ++ AK + EF + I + + Sbjct: 366 AMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 162/389 (41%), Positives = 222/389 (57%), Gaps = 40/389 (10%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +VT AM V++A + W+ + G + + YG LP + Sbjct: 5 VTLIPGDGIGPEVTRAMTTVLEA-------SGVDLEWIRVEAGVEVIEKYGTP--LPPQV 55 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L+ IRE RVAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + D Sbjct: 56 LESIRETRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QDID 112 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+ED+YAGIE++ + +A + + G E IGIKP SE G++R Sbjct: 113 LVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGSRR 169 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 +V+ A EYA N R VT VHK NIMKFT+G F ++A+E Sbjct: 170 IVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY---------------- 213 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I +D+I D Q++ +P YDV+ NL GD ISD A +GG+G+APGANI Sbjct: 214 ----PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANI 269 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAK 387 GD A+FEA HG+APKYAGQ+KVNP ++ILS MMLR++G EAA + ++ I K Sbjct: 270 GDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAEGK 329 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VTYD + + + E +AI + Sbjct: 330 YVTYDLAQ----GEPVGTQEMAEAIAARV 354 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 124/390 (31%), Positives = 189/390 (48%), Gaps = 62/390 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A+ ++ + I W + + T+ +P Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFK-------FADVPIKWESVDVTPRPTE--DGRFRMPQS 2028 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 +LD+IR++ + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G +P K+ Sbjct: 2029 SLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYKN---V 2085 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V REN+E Y+GIE + IK +EE ++ Sbjct: 2086 DLVTVRENTEGEYSGIEHVIVDGVVQ-----------------------SIKLITEEASR 2122 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A +YA N R SVT VHK NIM+ ++G F + A Sbjct: 2123 RVARFAFQYAKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAHH--------------- 2167 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +EI D+ D ++ P +DV+ NL GD +SD A +GG+G+ P N Sbjct: 2168 -----REIEFCDMFLDTVCLNLVQDPTRFDVLVMPNLYGDILSDLAAGLIGGLGVTPSGN 2222 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN-A 386 IG+ A+FE+ HGTAP AGQD+ NP +++ SA MMLR+M + ADLI + I A Sbjct: 2223 IGETGAIFESVHGTAPDIAGQDRANPTALLFSAIMMLRYMNLNKHADLIESAVLATIREA 2282 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +T D CS++ I + Sbjct: 2283 KYLTADL------GGRSTCSQYTKEICRQI 2306 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 398 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 114/403 (28%), Positives = 189/403 (46%), Gaps = 67/403 (16%) Query: 15 TLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKS 74 TL+N + + + I GDGIG +++ ++ +V A + I W + Sbjct: 12 TLRNYSSSTSKIQKVTLIPGDGIGPEISESVKRVFSAV-------KAPIEWETVVVDA-- 62 Query: 75 TQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYY 134 + + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 63 ------NTGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCLSI 116 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G + + V+ REN+E Y+GIE + A+ Sbjct: 117 PGHKTRY---NNVNTVVVRENTEGEYSGIENQPVKGVAQ--------------------- 152 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F +++ Sbjct: 153 --SIKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY-- 208 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 I +++ D Q++L P + DV+ NL GD +SD A Sbjct: 209 ------------------PSIKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDLCA 250 Query: 315 AQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 +GG+G+ P NIG+ A+FEA HGTAP AG++K NP ++ILS+ MMLRH+G A Sbjct: 251 GLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFHEA 310 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I + + V + D CSE+ D +++ + Sbjct: 311 SIIENAVLNTLTEGKV-----KTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 119/392 (30%), Positives = 189/392 (48%), Gaps = 62/392 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG +VT A ++V++A K W G ++ + Y + ++P Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIP 52 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + I R+ +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + Sbjct: 53 KELNESIERTRIGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---P 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+V+ REN+E +Y+GIE + E +K +E+ Sbjct: 110 GVDLVVVRENTEGLYSGIEHEVVPGVVE-----------------------SLKIITEKA 146 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R+ + A YA R + +HK NIMK ++G F +++E Sbjct: 147 STRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY------------- 193 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 EI+ + I D Q+++ P +YD++ NL GD +SD A VGG+G+APG Sbjct: 194 -------PEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPG 246 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIG+ ++FEA HG+AP AG++ NP ++I S +MLRH+ +AA+ + + Sbjct: 247 ANIGERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRHLDEQDAANRVKAAVHHVYR 306 Query: 386 AKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D SEF D ++E + Sbjct: 307 EGKHLTRDM------GGTTSTSEFADKVVEAI 332 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 120/391 (30%), Positives = 183/391 (46%), Gaps = 63/391 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA + I W E + Q G +P+E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEERNV--TAIQGPGGKWMIPSE 83 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + + ++ +KGPL TP+ G S+N+ LR+ DLY +RP +G +P Sbjct: 84 AKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DV 140 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++V REN+E Y+GIE + IK +E +K Sbjct: 141 NIVTIRENTEGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASK 177 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A EYA N R +VT VHK NIM+ ++G F ++A Sbjct: 178 RIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA------------------ 219 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + K+I ++ D ++ P+++DV+ NL GD +SD A +GG+G+ P N Sbjct: 220 --ESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGN 277 Query: 328 IGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG A+FE+ HGTAP AG+D NP +++LSA MMLRHMG + A I I Sbjct: 278 IGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKD 337 Query: 387 KT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D KCS+F + I + Sbjct: 338 GKSLTKDL------GGNAKCSDFTEEICRRV 362 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 384 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 111/389 (28%), Positives = 171/389 (43%), Gaps = 66/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V A + +++ K + + G+++ + YG+ LP E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE-------KLDLPFEYSYYDAGDEALEKYGK--ALPDE 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 TL+ R+ + G G + V LR+EL + +RP + +G Sbjct: 54 TLEACRKSDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLY---PGL 106 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E +Y G E+ I+ + E ++ Sbjct: 107 DIVVVRENTECLYMGFEFGFG------------------------DVTEAIRVITREASE 142 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A E A R VT +HK N+MK T G F+D ++A++ Sbjct: 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY--------------- 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 EI D DA +++ P +DVI N+ GD +SD A VGG+G+AP AN Sbjct: 188 -----PEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G+ A+FE HG A AG+ NP ++IL+A MMLRH G+ E A + + +E I Sbjct: 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D LK EF + + + Sbjct: 303 KKTPDL------GGNLKTMEFANEVASLL 325 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 122/395 (30%), Positives = 180/395 (45%), Gaps = 55/395 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + GDGIG ++ A++ V+ A + I GEK Y Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA-------VPLRLETIEIGEKLYNKY-YTY 52 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV 141 + +T I + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + Sbjct: 53 GITEDTWSQIFRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNT-- 110 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 D+VI REN ED+YAGIE+ +K Sbjct: 111 -SAPEIDVVIIRENEEDLYAGIEY-----------------------HHTADTYESVKLI 146 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S G+++++R A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 147 SRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSN------- 199 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + D +++ P ++DVI NL GD +SD A G IG Sbjct: 200 -------------IQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIG 246 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +A ANIG + A+FEA HG+AP AGQ+ NP ++ +A MML H+G TE A I ++ Sbjct: 247 LAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALK 306 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T D + + EF AII N+ Sbjct: 307 KTIEDGIHTADIYNPSISSTKVGTKEFAQAIINNL 341 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 130/409 (31%), Positives = 197/409 (48%), Gaps = 62/409 (15%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A K + NGK ++ I GDGIG ++ + ++++A I W E+ Sbjct: 9 ATMKYVVTPNGK------KLVTLIPGDGIGPEIVESACRLIEAV-------GAPIEW-EV 54 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 S G +P +T++ I+ RV +KGPL TPVG G +S NV LR+ + + + Sbjct: 55 RRAGASVFREGIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRKLFEAFANV 114 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RPVR P+P + D+V+ REN ED+YA IE++ Sbjct: 115 RPVRELPSVPTPYRGRN-IDLVVVRENIEDLYAAIEYRETPGVT---------------- 157 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 I K S +G+++++R A E A A R VT K NI+K TEG F+ ++ Sbjct: 158 -------IAHKLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGWFQHIFEEI 210 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A E +I +I D Q++ P +++VI NLNGD Sbjct: 211 ASEY--------------------PDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLNGDI 250 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 ISD + VGG+G A N G E A+FE HGTAPKYAG++ +NP ++IL+A MMLR++ Sbjct: 251 ISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYID 310 Query: 369 WTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 E A+ I + + + +T D + + + + F DAII N+ Sbjct: 311 EFETAETIEQALIVTLEEGKALTRDV---VGDERAVSTTAFTDAIIANL 356 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 379 bits (974), Expect = e-104, Method: Composition-based stats. Identities = 141/405 (34%), Positives = 204/405 (50%), Gaps = 58/405 (14%) Query: 15 TLQNGKLNVPEN--PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 T K++V E+ +I I GDGIG + A LKV++AA E+ Sbjct: 6 TETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLA--------YEVREAG 57 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 S G +P ET++ IR+ RV +KGPL TPVG G +S NV LR+ + Y +RPVR Sbjct: 58 ASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVR 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + P+P D+V+ REN ED+YAGIE + A+ Sbjct: 118 EFPNVPTPYAG-RGIDLVVVRENVEDLYAGIEHMQTPSVAQ------------------- 157 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +K S +G++++VR A E A A R V K NIMK EG K Q+A+E Sbjct: 158 ----TLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEY 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +I +I D Q++ RP +++VI N+NGD +SD Sbjct: 214 --------------------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDL 253 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + +GG+G AP ANIG+E A+FEA HG+APKYAG++ +NP +++LSA MMLR++ Sbjct: 254 TSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFAT 313 Query: 373 ADLIVKGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI + + +T D G K +E+ +AII+N+ Sbjct: 314 ADLIENALLYTLEEGRVLTGDVVGYDRG---AKTTEYTEAIIQNL 355 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 117/401 (29%), Positives = 191/401 (47%), Gaps = 65/401 (16%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 G+ + IEGDGIG +++ ++ + AA I W + + + Sbjct: 47 GQKGADGKYTVTLIEGDGIGPEISQSVKDIFSAA-------NAPIKWEPVDV---TPILK 96 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 +P + ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G Sbjct: 97 DGKTAIPDDAIESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYK 156 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +P + D V+ REN+E Y+GIE + I Sbjct: 157 TPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQ-----------------------SI 190 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K ++E ++R++R A +YA + ++ V +VHK IMK ++G F + ++A++ Sbjct: 191 KLITKEASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKD------- 243 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQ 316 ++ + D +I+ P Y+ V+ NL GD +SD A Sbjct: 244 -------------FPDVEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGL 290 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GG+G+ P NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A I Sbjct: 291 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAGRI 350 Query: 377 VKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + K +T D K SE+ +AI++ + Sbjct: 351 QKAIFDTLAEGKALTGDL------GGKAKTSEYAEAIMKKL 385 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 109/409 (26%), Positives = 177/409 (43%), Gaps = 62/409 (15%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A + T K + +N + G GIG +++ A+ + AA + I W Sbjct: 287 AMIPRYTFSQKKKSQKQNHKVVLFPGHGIGPEISQAVCDIFAAA-------KVPIDWEHH 339 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 K G + E+L+ + Y+ +KGP TP+G G RSLNV +R++L+L+ + Sbjct: 340 EIYTKPINEAGD--LIKEESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANV 397 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RP R G +P + D+V REN+E Y+G+E E Sbjct: 398 RPCRSLAGVKTPYSN---VDLVTIRENTEGEYSGLEHAVVPGVVE--------------- 439 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S+ + + R A E+A N+R V HK +MK +G F + ++ Sbjct: 440 --------NLKIISQPACENIARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKI 491 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + E EI + D ++ P +DV+ NL GD Sbjct: 492 SSEY--------------------PEIEYTEEQIDTVCMKLSKNPEVFDVMVMPNLYGDI 531 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A +GG+G+ NI CA++EA HGTAP AG +K NP +++LS MML+ MG Sbjct: 532 VSDLCAGLIGGLGLTASGNISHTCAVYEAVHGTAPDIAGLNKANPTALLLSGVMMLKAMG 591 Query: 369 WTEAADLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I + + + K +T D +++ A+I ++ Sbjct: 592 LQKEGFAIEEAVIKTLSEGKFLTGDL------GGKATTTDYTKAVIGHI 634 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 122/389 (31%), Positives = 183/389 (47%), Gaps = 55/389 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG ++ A+L ++ A E +I I GEK + + ++ Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKA-------EARIRLETIEVGEKLYVKH-YSSGISEQS 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELT 147 + I V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + Sbjct: 59 WESIERTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL---HPNL 115 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++ I REN ED+YAGIE+ R + +K S G + Sbjct: 116 NLTIIRENEEDLYAGIEY-----------------------RQTHNMYESVKLISRTGCE 152 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 +++R A EYA+ N+R VT + K NIMKF++G F ++A+E Sbjct: 153 KIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEY--------------- 197 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I + I D ++ +P +DVI NL GD ISD A G +G+A AN Sbjct: 198 -----PQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSAN 252 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG+ A+FEA HG+AP AGQD NP ++ +A MML H+G + A LI + I Sbjct: 253 IGEHYAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDG 312 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D K + EF + +++ + Sbjct: 313 MHTADIYNKDHSTKKVGTKEFAEEVVKRL 341 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 111/389 (28%), Positives = 173/389 (44%), Gaps = 66/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIGV+V A L +++ + + ++ G+ + G LP E Sbjct: 5 KIAVIPGDGIGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TALPEE 55 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 TL+ + E R + G G + V LR+E DL+ LRPV+ G P Sbjct: 56 TLEAVGEARATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLY---PDL 108 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D VI REN+ED+Y G E + + + + ++ Sbjct: 109 DFVIVRENTEDLYVGDE------------------------EYTPEGAVAKRIITRTASR 144 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ + A +YA VT VHK N++K T+G F+D Y++A E Sbjct: 145 RISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY--------------- 189 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 ++ D DA ++ +P E+ I NL GD +SD A +GG+G+AP AN Sbjct: 190 -----PQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAPSAN 244 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG++ ALFE HG+AP+ AG++ NP ++IL+ +ML+H+ + A I K ++ + Sbjct: 245 IGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTLAEG 304 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT D L E I ++ Sbjct: 305 LVTPDL------GGKLGTMEMAAEIARHL 327 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 112/399 (28%), Positives = 186/399 (46%), Gaps = 71/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG +V P +K+++ E ++ G + + YG LP + Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPED 52 Query: 88 TLDLIREYRVAIKGPLTTPVGG---GIRSLNVALRQELDLYICLRPVRYY-------QGT 137 T++ +E + + G +T+P G +S + LR+ LY +RP+ + + Sbjct: 53 TIEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIA 112 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D+VI REN+ED+Y G E R I Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRE------------------------RLENDTAIA 148 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G++R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 149 ERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY----- 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I D + D+ ++ P ++DVI N+ GD +SD +A + Sbjct: 204 ----------------NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP ANIGD+ ALFE HG+AP AG+ NP + ILS M+ ++G E DLI Sbjct: 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ + K VT D LK + GD I+ + Sbjct: 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEILNYI 340 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 117/394 (29%), Positives = 183/394 (46%), Gaps = 63/394 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + +IEGDGIG +++ ++ K+ AA I W S +P Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESCDV---SPIFVNGLTTIP 85 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 + I + VA+KGPL TP+G G RSLN+ LR+ L+ +RP + +G + E Sbjct: 86 DPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---E 142 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+V+ REN+E Y+GIE + IK + + Sbjct: 143 NVDLVLIRENTEGEYSGIEHIVCPGVVQ-----------------------SIKLITRDA 179 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 ++R++R A EYA A R V +VHK I + +G F + +L++E Sbjct: 180 SERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEY------------- 226 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEY--DVIACMNLNGDYISDALAAQ-VGGIGI 322 ++ ++ + D + +++ P+ Y V C NL GD +SD + G +G+ Sbjct: 227 -------PDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGL 279 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 P ANIG + ++FEA HG+AP AGQDK NP +++LS+ MML HMG T AD I + Sbjct: 280 TPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLS 339 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + R D A S F +A+I+ + Sbjct: 340 TIASGP----ENRTGDLAGTATTSSFTEAVIKRL 369 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 121/388 (31%), Positives = 174/388 (44%), Gaps = 55/388 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + GDGIG ++T A++ ++ AA + + GE+ G +P E Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA-------GAHLDAEYVEVGEQVYLR-GNTSGIPQEA 75 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 D I RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P D Sbjct: 76 WDSIARTRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHPDMD 133 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN ED+YAGIE R + +K + G++R Sbjct: 134 VVIVRENEEDLYAGIEH-----------------------RQTQDVAQCLKLITRSGSER 170 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + R A EYA + R +T + K NIMK T+G F ++ARE Sbjct: 171 IARYAFEYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY---------------- 214 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 EI I D + + RP +YDV+ NL GD +SD A G +G+ NI Sbjct: 215 ----PEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQMTGSVGLGGSVNI 270 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G A+FEA HG+AP A +D NP ++L+A MLRH+ A ++ + Sbjct: 271 GSGGAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHLKLDSIAAKVMNAWLCTLEEGI 329 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + F +A+IE + Sbjct: 330 HTVDIAG-AHTKERAGTRRFTEAVIERL 356 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 363 bits (931), Expect = 9e-99, Method: Composition-based stats. Identities = 134/390 (34%), Positives = 189/390 (48%), Gaps = 60/390 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I+GDG+G DV A L V+DA +K I ++ G + + YG + LP ET Sbjct: 8 VAVIKGDGVGPDVINASLLVLDAVKKK---FNLDIEYVPAVAGLNTVEKYGTN--LPKET 62 Query: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 LD ++E +KGP TTP G + S NV +R+ DLY +RP + PS Sbjct: 63 LDTLKETDCVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI---KPNV 119 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 DMVI REN+E +Y+G+++ R + IGI+ + + + Sbjct: 120 DMVIVRENTEGMYSGLDF-----------------------RVNQETTIGIRVITRKACE 156 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+V+ A + A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 157 RIVKYAFKLAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKH--------------- 200 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 ++ D DA Q + +P YDVI NL GD ISD A VGGIG AN Sbjct: 201 -----PDVKADDAHVDAITQWFIKQPEFYDVIVTENLFGDIISDEAAMVVGGIGTGASAN 255 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IGD+ A+FE HG+ PKY G DKVNP I+S +MML M + EA I + + Sbjct: 256 IGDKYAMFEPIHGSVPKYTGMDKVNPIGTIMSVKMMLDWMDYKEAGKAIEDAVYKVLEEG 315 Query: 388 -TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +TYD KCSE G I + Sbjct: 316 KILTYDL------GGTAKCSEVGKEIASKV 339 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 362 bits (930), Expect = 1e-98, Method: Composition-based stats. Identities = 115/388 (29%), Positives = 173/388 (44%), Gaps = 53/388 (13%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG ++ A LKV+ + ++ +I G K + G + + Sbjct: 6 ITVAYGDGIGPEIMDATLKVI-------LEAGAELEIEKIEIGFKVYSM-GNPSGIEPSS 57 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 + ++ +V +K P+TTP GGG +SLNV +R+ L LY +RP Y P D Sbjct: 58 WESLKRTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY--APFIHTKHPGID 115 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN ED+Y GIE + +K + +GT+R Sbjct: 116 LVIIRENEEDLYGGIEHRQGV-----------------------DSFQALKIMTRQGTER 152 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 ++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 153 IIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEY---------------- 196 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I + I D ++ P +DV+ NL GD +SD G +G+ ANI Sbjct: 197 ----PQIEKEHWIIDIGSAKLADNPQSFDVLVLANLYGDILSDVAVQIAGSVGLGASANI 252 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G E ++FEA HG+AP+ AGQ+ NP ++L+A ML H+G AD + I Sbjct: 253 GHEYSMFEAIHGSAPRRAGQNVANPSGLLLAAVQMLIHIGQNAVADRVYNAWLKTIEEGI 312 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 TYD R + EF +I+N+ Sbjct: 313 HTYDIFREGVSKVKVGTREFARHVIKNL 340 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 114/390 (29%), Positives = 181/390 (46%), Gaps = 56/390 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + GDG+G ++ ++L+++ ++ +I I G+K + G + Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEII-------FEAGAEIQIDTIEIGQKIYEK-GWPSGISD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P Sbjct: 54 SGWETLKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----K 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN ED+Y+GIE+ R K +E + Sbjct: 109 MDIVIIRENEEDLYSGIEY-----------------------RQTLDTYNCTKVITESTS 145 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 146 ERICRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEY-------------- 191 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I ++ I D +I P ++DVI +NL GD ISD A G +G+ Sbjct: 192 ------PDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGLGGSI 245 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+E A+FEA HG+AP A QD NP ++ +A ML ++G E A + + + Sbjct: 246 NIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKS 305 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + + +F + II N+ Sbjct: 306 GVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 127/388 (32%), Positives = 181/388 (46%), Gaps = 57/388 (14%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL 89 I GDGIG ++ +++ V+DA W Y G + G LP ET+ Sbjct: 16 TLIPGDGIGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGDP--LPRETI 66 Query: 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 149 I ++A+KGPLTTP GGG RS+NV LR+E +L+ +RP P E D+ Sbjct: 67 QSIHHNKLALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IPGGRFENVDI 122 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 + REN + YA E D P + + G R+ Sbjct: 123 TLIRENLDGFYAAFEHYMPIGD------------------DPHAVAMCAGFNTRTGCHRI 164 Query: 210 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNP 269 +R A EYA+ N R VTLVHK NI+K G F + G ++A+E G Sbjct: 165 IRYAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGR-------------- 210 Query: 270 NTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329 I ++ I DA Q++L P +DVI NL GD +SD +A +GG+G+APG NIG Sbjct: 211 -----IAFEERIVDACAMQLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIG 265 Query: 330 DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME-GAINAKT 388 + A+FEA HG+AP AG+ NP +++L+A MML H+G T+ A + + + Sbjct: 266 KQAAIFEAVHGSAPDIAGKGIANPLALMLAAAMMLDHVGKTDLATRLRNAIRITTLEDGI 325 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D K E A+I + Sbjct: 326 RTPDL------GGTAKTRELTQALISRI 347 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 133/391 (34%), Positives = 190/391 (48%), Gaps = 33/391 (8%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG G ++ A V+D A KI W G+++ + LP T Sbjct: 6 VTLVPGDGSGPELVDAARSVLDHAAR---LSGFKIDWDVHQAGQRALAE--SESLLPDAT 60 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-- 146 L+ IR A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR S + PE Sbjct: 61 LNSIRTNGAALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEEPERPH 119 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAG+E+ S A V++ L G P + +KP + G Sbjct: 120 VDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTPHGC 175 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+V A +A + R V V TEG F ++A Sbjct: 176 ERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARH-------------- 221 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 I + V A ++ P +DV+ NL GD ISD AA VG +G+APGA Sbjct: 222 ------PSIASRTVPVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGA 275 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG A+FEATHG+AP++AG ++NP ++I S M+L H+G E A I +E + A Sbjct: 276 NIGAHHAVFEATHGSAPEFAGSGRLNPTALIFSGCMLLDHLGEHETAARIRAAVEDVVAA 335 Query: 387 K-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T+D A EF A+ + + Sbjct: 336 GEVLTFDLLAPQRSADAATTVEFTRAVTDRL 366 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 357 bits (917), Expect = 4e-97, Method: Composition-based stats. Identities = 114/390 (29%), Positives = 176/390 (45%), Gaps = 65/390 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I IEGDGIG +V PA +V++A + ++E G ++ + G V P ET Sbjct: 5 ICLIEGDGIGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PEET 55 Query: 89 LDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ++ I + G T+P G LR+ LDLY +RP + P P Sbjct: 56 VEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRP---VPGSRPG- 111 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN+E +Y E + I S++ + Sbjct: 112 VDLVIVRENTEGLYVEQERRY------------------------LDVAIADAVISKKAS 147 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 148 ERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKD--------------- 192 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + ++D+I D Q+++RP +DVI NL GD +SD A VGG+G+AP Sbjct: 193 -----FPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSG 247 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIGD A+FE HG+AP AG+ NP + ILSA MML ++G EAA + K ++ + Sbjct: 248 NIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLER 307 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D F +A++E + Sbjct: 308 GPRTPDL------GGDATTEAFTEAVVEAL 331 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 355 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 113/393 (28%), Positives = 176/393 (44%), Gaps = 69/393 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG VT A+ +V++A + + +V G +P E Sbjct: 40 TVTLIPGDGIGPLVTGAVEQVMEAMHAPVHF--------------ERYEVLGNMRKVPEE 85 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 ++ ++ +V +KG L TPVGGG+ SLN+ LR+ELD++ L G V E Sbjct: 86 VIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGL---VTRHENV 142 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E Y+G+E + E +K ++ ++ Sbjct: 143 DIVVIRENTEGEYSGLEHEVVPGVVE-----------------------SLKVITKFCSE 179 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A EYA N+R VT VHK NIMK +G F + ++A+ G Sbjct: 180 RIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG------------- 226 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I ++I D Q++ +P ++DV+ NL G+ I++ A GG G+ PG N Sbjct: 227 -------ITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGN 279 Query: 328 IGDECALFEATHGTA----PKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 +G E A+FE K Q K NP +++LS+ MMLRH+ + AD + ++ Sbjct: 280 VGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQV 339 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I R D E DA+I + Sbjct: 340 IKEGK-----YRTKDLGGDCTTQEVVDAVIAAL 367 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 352 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 171/385 (44%), Gaps = 64/385 (16%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL 89 IEGDGIG ++ PA +KV+DA + + + G + G + L Sbjct: 4 AVIEGDGIGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNNDL 54 Query: 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 149 + I+ + G +TT +S+ + +R+ELDLY +RPV+ G V D Sbjct: 55 ETIKGCDAVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGITG-VTGRNDFDF 113 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 +I REN+E +Y+GIE + + +G++R+ Sbjct: 114 IIVRENTEGLYSGIE------------------------EIGPELSWTKRVVTRKGSERI 149 Query: 210 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNP 269 A + A ++ +T+VHK N++K ++ F D Q A Sbjct: 150 AEYACKLAKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTA-------------------- 187 Query: 270 NTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329 + + +D++ D+ +++RP YD++ NL GD +SD AA VG +G+ P ANIG Sbjct: 188 -SANGVEYEDMLVDSMAYNLIMRPERYDIVVTTNLFGDILSDMCAALVGSLGLVPSANIG 246 Query: 330 DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTV 389 ++ A FE HG+AP AG+ NP + IL +M+L MG + +I + + + K + Sbjct: 247 EKYAFFEPVHGSAPDIAGKGIANPLAAILCVKMLLEWMGEPR-SQIIDEAIAYVLQKKII 305 Query: 390 TYDFERLMDGAKLLKCSEFGDAIIE 414 T D E G+A+ E Sbjct: 306 TPDL------GGTASTMEVGNAVAE 324 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 350 bits (898), Expect = 6e-95, Method: Composition-based stats. Identities = 108/401 (26%), Positives = 167/401 (41%), Gaps = 69/401 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GDGIG +++ + L +++A + + ++ G+ + G+ Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAIND---NFPLSLEIKKLEAGDAVLKNTGK-- 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 LP ET + I+ +K P+ G + + V LR+ LDLY +RP + Y PS Sbjct: 56 ALPDETFEAIKNSDACLKAPV----GESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D+VI REN+ED+Y G E+ + + S Sbjct: 110 -RDDVDLVIVRENTEDLYTGEEFDIG------------------------DAAVAFRIIS 144 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ +KR+ A A VT VHK N+MK T+G F ++A + Sbjct: 145 EKASKRIANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVAND----------- 193 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ +++ DA ++ +P +DVI NL GD +SD A VGG+G+ Sbjct: 194 ---------FPDVKFEEMYVDACAMNLIRQPQLFDVIVTTNLFGDILSDESAQVVGGLGM 244 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EAADL 375 AP ANIGD LFE HG A AG+ NP S ILS +MML +G E Sbjct: 245 APAANIGDNFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLDWLGNKHNDQKCIEVGQK 304 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D EF II + Sbjct: 305 LEDVVYDIVKNNIKTKDI------GGDKTTMEFTKEIISRL 339 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 119/399 (29%), Positives = 173/399 (43%), Gaps = 63/399 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 L + I GDGIG + + A+ ++ A I + EI Sbjct: 15 LKYGGKYTVTLIPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNKSS 67 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 L E + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G + Sbjct: 68 GDAL-HEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT 126 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D I REN+E Y+G+E ++ E +K Sbjct: 127 ---RHDNVDFAIIRENTEGEYSGLEHQSVPGVVE-----------------------SLK 160 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E +KR+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 161 IITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA---------- 210 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 N I KD+I D Q + RP ++DV+ NL G +S+ +A VGG Sbjct: 211 ----------NGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGG 260 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ PGAN G + ALFE G+ + NP + ILSA +MLRH+G + ADLI Sbjct: 261 PGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINA 320 Query: 379 GMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T+T D +F AI+E M Sbjct: 321 ATYSVIEEGKTLTKDL------GGSASTGDFTHAILERM 353 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 104/396 (26%), Positives = 164/396 (41%), Gaps = 63/396 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + I IEGDGIG +V PA V++A K ++E G ++ + G V Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV 53 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P TL+ + + G T+P G +R++LDL+ +RP +++ P Sbjct: 54 --PEATLEAVTHTDATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHHP---VP 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+++ REN+E +Y E I Sbjct: 109 GSRPG-VDLIVVRENTEGLYVEQERSYLEG----------------------EIAIADTV 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + + R+ A A + R + + HK N++ T+G F + A Sbjct: 146 ITRKASARIGEYAARLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAAR--------- 196 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 E+ +D+I D Q++ P +DVI NL GD ISD A VGG+ Sbjct: 197 -----------FPEVKTQDIIIDNCAMQLVRNPERFDVIVTTNLFGDIISDLTAGLVGGL 245 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 GIA NIG + A+FE HG+AP AG+ NP + ILS MML H+G EAA + + Sbjct: 246 GIAASGNIGIKHAVFEPVHGSAPDIAGKGIANPAATILSGVMMLDHLGEHEAARRVEAAV 305 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D +F +A+ ++ Sbjct: 306 DKVLQEGPRTPDL------GGNATTLQFAEAVARSL 335 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 345 bits (886), Expect = 2e-93, Method: Composition-based stats. Identities = 136/395 (34%), Positives = 204/395 (51%), Gaps = 38/395 (9%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDG G ++ A V+D A A + W G+ + + G+ L Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTA---AGSAGFHLDWDVRPAGQGALRSVGE--LL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 PA TLD IR VA+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + Sbjct: 57 PASTLDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAV---D 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+Y+G+E+ ADS A V L E +KP + Sbjct: 114 SGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFG-----HADPGIAFSLKPITPG 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF--TEGAFKDWGYQLAREEFGGELIDGGP 262 G++R+V A+++A N R V + ++ ++ TEG F + +L E Sbjct: 169 GSRRIVAFALDHARKNGRRKVEV--GADVYRYPRTEGLFFEAARELGPEY---------- 216 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 +IV V ++ PA+ DV+ NL GD ISD AA VGG+G+ Sbjct: 217 ----------PDIVTATVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGM 266 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 APGANIGD A+FEATHG+AP++AG +++NP ++ILS M+L H+G A I + Sbjct: 267 APGANIGDRTAVFEATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRS 326 Query: 383 AINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 + VT+D A+ + + + +A+IE + Sbjct: 327 VLEEGRSVTFDLLPPDRAARAVTTTAYAEAVIERL 361 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 100/392 (25%), Positives = 167/392 (42%), Gaps = 62/392 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG ++ A+ + E +S ++I + + E Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFN-------E 104 Query: 88 TLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + G + Sbjct: 105 AITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT---RHN 161 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI R+N+E Y+ +E + S E +K +EE Sbjct: 162 NVDLVIIRQNTEGEYSHLEHENVSGVIE-----------------------NLKVTTEEA 198 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 ++ + A ++A +DR VT VHK NIMK +G F +++ Sbjct: 199 CMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSY------------- 245 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I +I D Q++ P ++DV+ NL G+ +S+ A+ VGG GI PG Sbjct: 246 -------PNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVSNIGASLVGGPGIVPG 298 Query: 326 ANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIG + A+FE+ + T G+D NP S++ ++ +ML H+ +T ADLI + + Sbjct: 299 ENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLEHLEFTAYADLINSAILKVV 358 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D ++F A+ + Sbjct: 359 QRGVLTADV------GGSHTTTQFLSALKSEL 384 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 117/409 (28%), Positives = 187/409 (45%), Gaps = 48/409 (11%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG----EKSTQVYGQ 80 + + Y+ GD G D+ L V+ + I W+ G EKS +GQ Sbjct: 13 DRYKVCYMPGDDSGFDMMEGALVVL-------LSMDLPIDWVRADLGWCMWEKSVNKFGQ 65 Query: 81 DVW----LPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQ 135 +P ET+D IR + +T+ G G +S + +RQ DLYI LRP + Sbjct: 66 GDPRCNTVPPETIDKIRSSDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPAKTLP 125 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K D+V+FREN+ED+Y+ +E+ + + K G+++ R Sbjct: 126 DLGSPLKGDPKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHK------GMERFRKMGDVA 179 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + S G +R++RAA EYA + R V +K N+++ T+G K ++A+E Sbjct: 180 VSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEY--- 236 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 I + ADA ++ P +Y VI N+ GD +SD + Sbjct: 237 ---------------EQYGITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQ 281 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 GG+G AP NIG+ A+FE G+ PKYA Q +VNP +++L+++MML ++G +A Sbjct: 282 LTGGLGFAPSGNIGENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLGLDQAGQK 341 Query: 376 IVKGMEGAI---NAKTVTYDFERLMDGA-----KLLKCSEFGDAIIENM 416 I + + KT+TYD R E AI + + Sbjct: 342 IEWAINEVLKENRPKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 57/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I DGIG +V A L+V++A ++ G+ I G + G V + Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKR--SGDFSIHTETFDWGSDYYKKNG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ ++++ G + P + L + + Q D Y +RP + G P+ Sbjct: 58 PADGLEQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 ++ P D VI RENSE Y+G +A PE G + Sbjct: 118 RNCGPGDLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVA 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G R++R A + A A R +T+V K N + + + ++++E Sbjct: 159 IFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKE-------- 210 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ ++ DA ++ L+P D I NL+ D +SD A G Sbjct: 211 ------------FPDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHADILSDLAGALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+AP ANI E ++FE HG+A G+ NP + +A ML H+G +AA + Sbjct: 259 LGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFWTAAQMLEHLGEKDAATRL 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E A +T D + DA+ E + Sbjct: 319 MSAVERVTEAGILTPDV------GGTADTQQVTDAVCEAI 352 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 340 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 56/398 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG++V A ++VV+ + G I + I G + +G+ ++ Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVS 101 Query: 86 AETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + LD +R++ + G + P + L +ALR L LY +RPVR + GT P+ Sbjct: 102 EDCLDTLRKFDAGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLN 161 Query: 143 HP-ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 E D ++ RENSE Y+G + G + P + Sbjct: 162 TATEGIDWMLVRENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMF 202 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + G +R++R A E A + R +T+V K N M+ + ++A++ Sbjct: 203 TRVGIERIMRFAFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKD---------- 252 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++ ++ DA +++ +P D I NL+ D +SD AA G IG Sbjct: 253 ----------FPDVTWDKMLVDAMTVRMVAKPQSIDTIVGTNLHMDILSDLAAALAGSIG 302 Query: 322 IAPGANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 +AP +N+ ++FE HG+A G+ NP + SA ML +G EAA ++ Sbjct: 303 VAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLSWLGEKEAAKQLMD 362 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E A +T D DA+ + + Sbjct: 363 CVEKVCAAGILTPDL------GGTSNTQGVVDAVKKEI 394 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 98/419 (23%), Positives = 167/419 (39%), Gaps = 59/419 (14%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 P+ + T++ P+ I + GDGIG +V V+ A + + E Sbjct: 125 PSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAGS---LEGIEFGFQE 181 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQE 121 + G + + G V LP ETL + ++ + G + + + LR Sbjct: 182 MPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSG 239 Query: 122 LDLYICLRPVRYYQ----GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 L ++ LRP + + E D+++ RE + IY G Sbjct: 240 LKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFG--------------- 284 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 + G K E G + + R+ R A E A R + V K N+++ + Sbjct: 285 ---KPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFETAQKR-RGKLCSVDKANVLEAS 340 Query: 238 EGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 ++ +A E ++ + + D Q++ P ++D Sbjct: 341 -MLWRKRVTAMASEY--------------------PDVELSHMYVDNAAMQLVRNPKQFD 379 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSI 356 I N+ GD +SD + G IG+ P A++G+ LFE HG+AP AGQDK NP + Sbjct: 380 TIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKANPLAT 439 Query: 357 ILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +LSA M+LR+ +G AA I + ++ T D G KL+ C E G+ +++ Sbjct: 440 VLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEA--GTKLVGCKEMGEQVLK 496 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 112/397 (28%), Positives = 171/397 (43%), Gaps = 57/397 (14%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 ++VP I GDG+G ++ A+L ++ A + + I ++I G + Sbjct: 5 SMSVP----ITVAYGDGVGPEIMEAVLFILKEA-----RADVSIETVDI--GHNQYKKE- 52 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + + I R+ +K P TP G G +SLNVALRQ L LY+ +RP Y P Sbjct: 53 WTSGIAPSAWESISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPV 110 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+VI REN ED Y+G+E K E +K Sbjct: 111 VGTKHPDLDVVIIRENEEDTYSGVEHK-----------------------LSEDTHECVK 147 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + ++++ A YA A++R VT K NIMK T+G ++A+ Sbjct: 148 ISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGY------- 200 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I I D + +I P ++DV+ NL GD +SD ++ G Sbjct: 201 -------------PDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVSLSSGS 247 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 IG+ ANIGD A+FEA HG+AP AG++ NP ++ +A ML H+G + A +I Sbjct: 248 IGLTGSANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQLDKAGVIRNA 307 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D + EF AI+ N+ Sbjct: 308 FLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVGNL 344 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 110/407 (27%), Positives = 171/407 (42%), Gaps = 56/407 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + + + + I I GDG G + LKV+ AA A K + + G + Sbjct: 7 KEDRTTMQKTYKIAVIPGDGTGPEQVREGLKVLHAA---AGKEGFALETTVLDWGGEYYL 63 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRY 133 G+ LP + ++ ++ Y G + P G + + + LR ELD YI LRPV+ Sbjct: 64 RTGE--VLPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKL 121 Query: 134 YQGTPSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 Y G +P+ K PE D V+ REN+E +YAG G K P Sbjct: 122 YPGVETPIAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTP 162 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + I + +G +R VR A EY R VTL K N++ F ++ ++ Sbjct: 163 DEVAIQTSINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGE 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 E +I DA ++ P +DVI N+ GD I+ Sbjct: 223 EY--------------------PDIERDYAHVDAICMWMVKNPEWFDVIVTDNMFGDIIT 262 Query: 311 DALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 D A GG+GIA G N+ E ++FE G+APKY G++ +NP + + + MML +G Sbjct: 263 DLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVINPLAAVCAGAMMLEQLGE 322 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA I + ++ + L G E GD ++ ++ Sbjct: 323 TGAAARIEEAVKKVCAGH-----LKSLAAGRMGYGTDEVGDLVVSHL 364 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 96/400 (24%), Positives = 159/400 (39%), Gaps = 56/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDGIG +V PA + + E G + + G + +G V + Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ +R+ + G P + L + + Q LD Y +RP R G P+ Sbjct: 58 PADGLEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 K E D VI RENSE Y+G+ + P + Sbjct: 118 KRCTAEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAATDVS 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R++R A A + R +T+V K N + + + +++RE Sbjct: 159 MMTRAGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISRE-------- 210 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + DA +++ RPA D I NL+ D +SD AA G Sbjct: 211 ------------FPDVRWDKELVDAATARMVNRPASLDTIVATNLHADILSDLAAALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GIAP NI E ++FE HG+A G+ NP S M+L H+G +AA + Sbjct: 259 LGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGTFWSVVMLLEHLGEHQAAARM 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +E + + D + A+ +++ Sbjct: 319 MRAVESVTADQAL-----HTRDLGGTATTEQVTQAVCQHL 353 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 95/394 (24%), Positives = 160/394 (40%), Gaps = 67/394 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDGIG ++ + V A + + E++ + + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE------DI 62 Query: 86 AETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + IR RVA+KG + T + +S N LR LDLY + + G V Sbjct: 63 RNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTR 119 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 + D++I REN+E Y+ +E ++ + E +K ++ Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------SLKIITK 156 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 157 AKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----------- 205 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 +I +++I D Q++ RP ++DV+ NL G+ +++ A VGG G+ Sbjct: 206 ---------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLV 256 Query: 324 PGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 GAN G A+FE AT T A ++ NP + +L++ MML H+ A I K + Sbjct: 257 AGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLA 316 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +++ + D SE II ++ Sbjct: 317 SMDNEN-----MHTPDIGGQGTTSEAIQDIIRHI 345 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 106/402 (26%), Positives = 169/402 (42%), Gaps = 66/402 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V LKV++ +K K + + G + +G+ LP E Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKKTGKT---FEKVFGHIGGDAIDRFGEP--LPEE 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLYICLRPVRYYQGTP-- 138 T + E G + P + +ALR+ L+LY +RP++ Y+ Sbjct: 57 TKKICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHV 116 Query: 139 SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K D+V RE S +Y G + E G Sbjct: 117 SPLKEKVIGSGVDLVTVRELSYGVYYG-----------------------QPRGLDEEKG 153 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + +R+ R A E A N R VT V K N++ ++ ++ ++ARE Sbjct: 154 FDTMIYDRKTVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREY--- 208 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + D Q++L+P+++DVI N+ GD +SD AA Sbjct: 209 -----------------PDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAA 251 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A+ GD+ L+E G+AP AG++ NP + ILS MML H G E A Sbjct: 252 LPGSLGLLPSASFGDKN-LYEPAGGSAPDIAGKNIANPIAQILSLAMMLEHSFGMVEEAR 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +E I T D + K + S+ GD I + + Sbjct: 311 KIERAVELVIEEGYRTRDIAEDPE--KAVSTSQMGDLICKKL 350 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 97/393 (24%), Positives = 176/393 (44%), Gaps = 65/393 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDG+G ++T ++ + +A I W I + + + V+ Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA-------ENIPIDWETINIKQTD---HKEGVY-- 75 Query: 86 AETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + + Sbjct: 76 -EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--- 131 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+++ REN+E ++G+E ++ E +K + Sbjct: 132 PDIDLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRP 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 T+R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 169 KTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY----------- 217 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I + +I D Q + +P ++DV+ ++ G + + AA +GG G+ Sbjct: 218 --------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVA 269 Query: 325 GANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 GAN G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + Sbjct: 270 GANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHET 329 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T D ++F + II + Sbjct: 330 IAEGKHT-----TRDIGGSSSTTDFTNEIINKL 357 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 118/400 (29%), Positives = 181/400 (45%), Gaps = 69/400 (17%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEK 73 ++ N K N + I I GDGIG +V A + V+D + ++ G++ Sbjct: 1 MSTSNKKDNKYQ---IAVIPGDGIGKEVMEATISVLDEL-------DVDFDYIYGIAGDE 50 Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRY 133 + +G LP ET+D++R+ + G G + V +RQE+ ++ LRPV+ Sbjct: 51 CNEEHGTP--LPQETIDIVRDSDACLFGA----AGETAADVIVKIRQEMKMFANLRPVKS 104 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 Y T S E D +I REN+E +Y + E Sbjct: 105 YPNTKSLF---ENVDFMIVRENTEGLYI-----------------------ADQEEETED 138 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 I + + E +R++ A +YA N+R VT VHK N++K T+G FK Y++ + Sbjct: 139 GAIAKRVITREAEERIIDYAFQYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKY- 197 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 +I +D DA ++ +P E+ V+ NL GD +SD Sbjct: 198 -------------------PDIDTEDFYVDATAMYLVTQPQEFQVVVTTNLFGDILSDEG 238 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 A VGG+G+ P ANIG + ALFE HG+AP AGQ K NP +++LSA MMLR++G +AA Sbjct: 239 AGLVGGLGLIPSANIGADGALFEPVHGSAPDIAGQQKANPIAMMLSAIMMLRYLGENDAA 298 Query: 374 DLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAI 412 D + + KT+T D E A+ Sbjct: 299 DKFDAAILKVLSEGKTLTGDL------GGSATTMEVAQAV 332 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 337 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 100/393 (25%), Positives = 166/393 (42%), Gaps = 69/393 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + GDG+G ++ + +V I + E+ ++S D L Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI-------GAPIDFEEVAVNQESEDATFTDALL- 119 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 ++ V IKG T G S NVALR L+LY ++ R + G V + Sbjct: 120 -----AMKRNGVGIKGNFATEPGQS--SRNVALRLNLNLYAFVQRCRNFPGV---VTRHQ 169 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+VI REN+E Y+ +E + E +K + E Sbjct: 170 NVDIVIIRENTEGEYSRLEHENVPGVVE-----------------------SLKIITREK 206 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R+ + A +YA+ ++R VT VHK NIMK +G F D +A+ Sbjct: 207 STRIAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY------------- 253 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 +I +I D Q++ +P ++DVI NL G+ + + A VGG G+ G Sbjct: 254 -------PQIEFNHMIIDNTCMQLVTKPQQFDVIVLPNLYGNIVGNVAAGLVGGAGLTTG 306 Query: 326 ANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 N+G + ALFE T + AG++ NP ++L++ ML ++G + A LI + I Sbjct: 307 INLGPQNALFEMGTRNSGRSLAGKNIANPCGMLLTSADMLEYLGHIKEAKLIRDSVVDVI 366 Query: 385 -NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K T D K S+ +A+++++ Sbjct: 367 GEQKIRTADL------GGSFKTSKVIEAVLKSL 393 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 337 bits (863), Expect = 7e-91, Method: Composition-based stats. Identities = 94/394 (23%), Positives = 160/394 (40%), Gaps = 67/394 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDGIG ++ + V A + + E++ + + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE------DI 100 Query: 86 AETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + IR RVA+KG + T + +S N LR LDLY + + G V Sbjct: 101 RNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTR 157 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 + D++I REN+E Y+ +E ++ + E +K ++ Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------SLKIITK 194 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 195 AKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----------- 243 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 +I +++I D Q++ RP ++DV+ NL G+ +++ A VGG G+ Sbjct: 244 ---------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLV 294 Query: 324 PGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 GAN G A+FE AT T A ++ NP + +L++ MML H+ A I K + Sbjct: 295 AGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLA 354 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +++ + D SE +I ++ Sbjct: 355 SMDNEN-----MHTPDIGGQGTTSEAIQDVIRHI 383 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 335 bits (860), Expect = 2e-90, Method: Composition-based stats. Identities = 99/406 (24%), Positives = 172/406 (42%), Gaps = 63/406 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG +V +KV++ EK K+++ E + G + G L Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEK---FGFKLNFNEFFVGGAAIDHCGYP--L 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGT 137 PAETL E + G + P + R + LR+ L+ LRP Y+G Sbjct: 57 PAETLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGL 116 Query: 138 P--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 P++ + DMV+ RE + IY G + ++ Sbjct: 117 EKFCPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQ------------------- 157 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ RAA E A+ + VT V K N+++ + +++ ++A++ Sbjct: 158 TKAFDTEVYYKYEIERIARAAFEAAMKRN-KKVTSVDKANVLQ-SSILWRETVTEMAKDY 215 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 E+ ++ + D Q++ P +DV+ C N+ GD ISD Sbjct: 216 --------------------PEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDE 255 Query: 313 LAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 A G +G+ P A++ + L+E G+AP AG+ NP + ILSA MMLR+ Sbjct: 256 AAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLN 315 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EAAD I ++ + + T D D + + +E G I + + Sbjct: 316 EAADAIESAVQKVLASGHRTADL---ADDSTPVSTAEMGTLITQAI 358 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 100/402 (24%), Positives = 156/402 (38%), Gaps = 56/402 (13%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG +V P ++V++AA K K+++ + + Q Sbjct: 1 MITNQQYKIAVIPGDGIGNEVVPEGIRVLEAASAK---FGFKLAFTTYDWS--CARYHSQ 55 Query: 81 DVWLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 +P++ ++ +R+ G + P + +L + +R+E D Y+ LRPVR G Sbjct: 56 GSMMPSDGIERLRDSDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGV 115 Query: 138 PSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ K P D I REN+E Y+ + G Sbjct: 116 PCPLANKKPGDIDFWIVRENTEGEYS-------------------QVGGRMFAGTEHEFV 156 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + GT R++R A + A R+ VT K N + + + + + E Sbjct: 157 TQEAIFTRRGTDRIMRYAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEY--- 213 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I D + + P +DV+ NL GD +SD Sbjct: 214 -----------------PDIRTDQYHIDILAARFAMSPERFDVVVGSNLFGDILSDLGPG 256 Query: 316 QVGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 G I +AP ANI E ++FE HG+AP AGQ NP I S MML H+G EA Sbjct: 257 ITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIWSGAMMLEHLGQPEA 316 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 A I++ +E + D D + G I Sbjct: 317 AAAIMQAIETVLTH----PDRVHTPDLGGRASTQQMGAEIAR 354 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 96/402 (23%), Positives = 158/402 (39%), Gaps = 60/402 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V KV++ K + +I+ + G + +G LP T Sbjct: 4 IAILAGDGIGPEVMVEAKKVLNTVASK---FDFEITTQDYDIGGAAIDNHGN--ALPDST 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + E + G + P + R + LR DL+ +RP S Sbjct: 59 MAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLS 118 Query: 142 K-----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + D+++ RE + DIY G E K + E E G Sbjct: 119 TLRSDISEQGFDVLVIRELTGDIYFG-EPKGRRGEGE------------------EETGF 159 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 S KR+ A + A + + VT V K N++ T ++ ++A E Sbjct: 160 DSMFYSRREVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEY---- 213 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D Q++ P ++DV+ C NL GD +SD A Sbjct: 214 ----------------PDVELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAMI 257 Query: 317 VGGIGIAPGANI-GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A++ D ++E G+AP AG NP + ILSA +MLR+ + AA Sbjct: 258 TGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAAK 317 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + A++ +T D + SE GD I + + Sbjct: 318 AIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 119/422 (28%), Positives = 188/422 (44%), Gaps = 61/422 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P + + GDGIG V P ++V++A +A I W + LP Sbjct: 3 RPTVVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECW---------CNEGNALP 53 Query: 86 AETLDLIREYRVAIKGPLTTP---------------VGGGIRSLNVALRQELDLYICLRP 130 T+ L+R++++ + G +T+ G S V +RQ +L +C+RP Sbjct: 54 DRTIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRP 113 Query: 131 VRYYQGTPSPVKH--------PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 + G P D+V+FR+N+E +YAG+EW + + ++ Sbjct: 114 CLSFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKF 173 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 E + ++ +++ +R+ AA ++A +VT+ K N+++ T G + Sbjct: 174 AAFANTP-GEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMME 232 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + Q+ ++ EI + DA + P EY VI Sbjct: 233 EVAKQVQKQY--------------------PEIALWSTNIDAQTMWLTKNPEEYGVIVAS 272 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQD--KVNPGSIILSA 360 NL GD ISDA A VGG+G A NIGDE A+FE THG+APKYA + VNP ++ILSA Sbjct: 273 NLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSA 332 Query: 361 EMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDFERLMDG-----AKLLKCSEFGDAIIE 414 MML H+G +E AD I K + + K TYD R+ G + DAI+ Sbjct: 333 AMMLDHIGESEKADRIRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILV 392 Query: 415 NM 416 ++ Sbjct: 393 HV 394 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 106/399 (26%), Positives = 183/399 (45%), Gaps = 56/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +V PA +V++ K +++++Y G ++ Q G+ L Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSK---HGLSFNFIDLYAGFQTFQETGK--AL 76 Query: 85 PAETLDLIRE-YRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P ET+ +++E + A+ G + +P G S VALR+E+ L+ +RPV+ +G Sbjct: 77 PDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + DMVI REN+ED+Y IE K Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTY------------------IDKATGTRVADATKRI 173 Query: 202 SEEGTKRLVRAAIEYAIAN----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 SE T+R+ A++ A+ + ++T+ HK N++ ++G F++ ++ Sbjct: 174 SEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEV--------- 224 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 N + +I + I D+ + ++ P +DVI NL GD +SD AA V Sbjct: 225 -------YESNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALV 277 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G +G+ P AN+G E + E HG+AP AG+ NP + I S +ML +G EAA I Sbjct: 278 GSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIY 337 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ + ++ + D + D ++ + Sbjct: 338 KAVDANLREGSI-----KTPDLGGKASTQQVVDDVLSRL 371 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 100/400 (25%), Positives = 162/400 (40%), Gaps = 57/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGIG +V LKV+ +K Y + + +G+ + Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADM--FLWNSEYYLQHGR--MM 57 Query: 85 PAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P LD+++ Y + G + P + L + +R+ Y+ LRPV+ +G P Sbjct: 58 PENGLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 142 KHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 H E + VI REN+E Y+ G + + Sbjct: 118 IHQERPINFVIVRENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTI 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +GT+R+ R A +YA + V K N + + + + +A E Sbjct: 159 ITRKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEY-------- 210 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I ++ DA + RP VI NL GD +SD +A VGG+ Sbjct: 211 ------------PDIQLEKYYIDALAAYFVQRPDTLQVIVASNLFGDILSDLGSALVGGL 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GI+P ANI E ++FE HG+AP AG+ K NP + I SA +ML+ +G + A +I+ Sbjct: 259 GISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIIL 318 Query: 378 KGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E +T D +E G+ I+ + Sbjct: 319 KAIEKVTEHGEKLTEDL------GGNSTTAEMGEEIVRQI 352 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 332 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 100/411 (24%), Positives = 172/411 (41%), Gaps = 66/411 (16%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 PA+ K TL K + + + G GIG + M++ V+A G+ + + Sbjct: 30 PARCSKRTLHR-KSKIGGRFFVTLLPGHGIGPE----MMRHVEAIFAC---GKVPVDFET 81 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPL-TTPVGGGIRSLNVALRQELDLYI 126 I + IR VA+KG + TT + N+ LR +L+LY+ Sbjct: 82 IIVDANVGDASSM-----DHAIKSIRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYV 136 Query: 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 + R + G + + D+V+ R+N+E Y+ +E + S E Sbjct: 137 NVVHCRNHPGINT---KHKGVDIVVIRQNTEGEYSCLEHEVTSGVVE------------- 180 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 +K + + ++ + EYA + R VT+VHK NIMK T+G F Sbjct: 181 ----------SLKIITWAKSFQIAKYCFEYARTHMRKKVTVVHKANIMKLTDGLFLKTCT 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++A+E +I + D+I D Q++ PA++DV+ NL G Sbjct: 231 EVAQEY--------------------PDIELNDIIIDNCCMQLVANPAQFDVMLVPNLYG 270 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + + + VGG G+ G N G E A+FE AT T G++ NP + + +A ML+ Sbjct: 271 NIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVATLYAAVDMLK 330 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+ + A +I + +E +N D D S+ + I++ + Sbjct: 331 HLELWDHAVVIRRAIEKTVNR-----DKVHTKDLGGDATTSKVVENILKEV 376 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 112/413 (27%), Positives = 169/413 (40%), Gaps = 82/413 (19%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V PA + V+ A + G + Q G+ LP+ Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALPS 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 TL R + G + +P G RS V LR+ELDLY +RPV + P +P Sbjct: 57 ATLTAARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 145 EL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D+V+ REN+ED+YAG E D I + + Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGAT----------------------AIAERVIT 152 Query: 203 EEGTKRLVRAAIEYAIANDR---------DSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 + R++R A + A A VT+VHK N+++ T G F+ ++A+ Sbjct: 153 RRASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAY- 211 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 ++ I +++ D Q+ RP +DVI NL GD +SD Sbjct: 212 -------------------PDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVA 252 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 A GG+G+AP AN+G+ ALFE HG AP AG+ NP + I ++L H+ A Sbjct: 253 CAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPA 312 Query: 374 D----------LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D I + + A T D ++ +A++ +M Sbjct: 313 DLASAMRGWSARIQRAIRHVRAAGPHTPDL------GGSAVTTDITNAVLSHM 359 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 94/393 (23%), Positives = 171/393 (43%), Gaps = 69/393 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDGIG ++ + V+ +K I + I ++S+ Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVL-------HKCGAPIDFEVIDIKDESS---------T 130 Query: 86 AETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + ++ + +KG +TT + +S+N +R++LDLY + P + G + Sbjct: 131 DAAIISLKRNGIGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT---RH 187 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+E Y +E + E +K +E+ Sbjct: 188 GQVDLVVIRENTEGEYGSLEHENVDGVVE-----------------------SLKIITEK 224 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ + A +YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 225 KSRRIAKFAFDYALQNNRRKVTAIHKANIMKLADGLFLETCREISKDY------------ 272 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I + +I D Q++ P ++DV+ NL G+ +S VGGIG+ P Sbjct: 273 --------TDIEFESMIIDNCCMQMVTNPQQFDVMVMPNLYGNIVSHIGIGLVGGIGLVP 324 Query: 325 GANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 G NIGD+ A+FE+ G ++ NP + ++ +MLRH+G + AD+I + Sbjct: 325 GKNIGDKYAIFESGARNIGSDLVGLNRANPCGFLFTSALMLRHLGLDDYADIIESAVRTT 384 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I R D ++F DA+I+ + Sbjct: 385 IKNGKC-----RTPDIQGDRTTADFIDAVIKEI 412 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 330 bits (845), Expect = 8e-89, Method: Composition-based stats. Identities = 107/414 (25%), Positives = 172/414 (41%), Gaps = 70/414 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P++ + + + GDGIG ++ + K+ + Sbjct: 30 IQSPSKNQFARYGG-------RHTVTLLPGDGIGPEMLDIVQKIFT-------FANVPVD 75 Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI-RSLNVALRQELD 123 + E K T + I+ VAIKG + T I +S NV LR+ LD Sbjct: 76 FEECQLDSKPT----SPESDLDNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLD 131 Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 L+ + P+ + ++V+ REN+E Y+G E + + E Sbjct: 132 LFANVLHCVSIPTIPT---RHKGINIVMIRENTEGEYSGHEHETVNGVVE---------- 178 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 +K C+ E +R+ R A +YAIA++R +T VHK NI K +G F Sbjct: 179 -------------SLKICTREKLERISRFAFDYAIAHNRKKITAVHKANIQKLADGLFLK 225 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++A +E+ I +I D Q++ RP ++D++ N Sbjct: 226 VVGEIAEKEY-------------------PSITFDSMIVDNASMQLVSRPQQFDIMLMPN 266 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEM 362 L G+ IS+ VGG G+ G NIGD+ A+FE T T AGQD NP + I + Sbjct: 267 LYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTAFIRAGVD 326 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ML ++G TE A+LI + AI K + D K S+ +A++ N+ Sbjct: 327 MLHYLGLTEYANLISDALFDAIVIKRL-----HTKDIGGTAKTSDVVNAVMRNI 375 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 328 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 109/401 (27%), Positives = 177/401 (44%), Gaps = 61/401 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + + GDGIG ++ PA +K++DAAV A I+W E+ G + YG+ Sbjct: 22 KQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGAT--PIAWTELPLGRSAIDEYGEHT-- 77 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG-IRS---LNVALRQELDLYICLRPVRYYQGTPSP 140 P +TLD + E + GP + RS + +R+ L+ +RP + ++G + Sbjct: 78 PTKTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNAI 137 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 V E TD+VI REN+E YA A + + + I Sbjct: 138 V---EGTDLVIVRENTEGFYADRNTFAGTGE----------------MMPTPDVAIMHGI 178 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + T+R+ A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 179 ITRAATERIAHEAFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQY-------- 229 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ I D DA ++ R ++DVI N+ GD +SD G + Sbjct: 230 ------------PDVAINDFHIDAATVHLVRRADKFDVIVTENMFGDILSDLAGEVAGSL 277 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EAA 373 GIAP N A+ +A+HG+AP AG+D NP ++ILS+ M+LR + AA Sbjct: 278 GIAPSINSSATHAMAQASHGSAPDIAGRDIANPIAMILSSAMLLRWLAAKFDDEKIARAA 337 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 D++ ++ + T D CS F DA++ Sbjct: 338 DIVEAAVDLTVAEGATTPDM------GGTSSCSGFADAVVA 372 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 98/402 (24%), Positives = 171/402 (42%), Gaps = 67/402 (16%) Query: 21 LNVPE-----NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 N+P+ + I DGIG + +++V + + E Y + Sbjct: 35 SNIPDATYGGRHTVSLIPADGIGQSLIMGIVEVFQ-------NSGVPVDFEECYITGDTN 87 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQ 135 + + + + A+KG T +G +S NV LR +LDLY + + Y Sbjct: 88 EEKMKSF---NDIKTSVLRNGTALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSYP 144 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 + + D+++ REN+E Y +E + E Sbjct: 145 ---TVITRHNNVDLIVIRENTEGEYTNLEHENIPGVIEM--------------------- 180 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 IK +++ ++R+ + A +YA+ N+R VT VHK NIMK ++G F ++A Sbjct: 181 --IKIITKKKSERIAKYAFDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGY--- 235 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 EI D+I D Q++ +P ++DVI NL G+ +S+ AA Sbjct: 236 -----------------PEIDFNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAA 278 Query: 316 QVGGIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 VGG G+ G N G+ +FE+ T + A ++ NP S++ +A +LRH+ ++ A Sbjct: 279 LVGGPGLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSMLFAATALLRHLQLSKHAQ 338 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LI + K VT + R +D SEF + +++ + Sbjct: 339 LIESCI-----HKIVTTNQARTVDIGGNTSTSEFFEILVKEV 375 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 326 bits (836), Expect = 8e-88, Method: Composition-based stats. Identities = 96/393 (24%), Positives = 173/393 (44%), Gaps = 60/393 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I IEGDGIG +V +K +++ + + + S+ + G K+ + +G +P ET Sbjct: 5 IVVIEGDGIGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MPKET 59 Query: 89 LDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-PSPV 141 +D + + G + P + LR+E+DLY +RP+ Y G SP+ Sbjct: 60 IDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPI 119 Query: 142 KHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 K E + VI+RE + IY G + ++ + Sbjct: 120 KERKLEGVNFVIYRELTGGIYFGKKGRSKNG----------------------KEAYDYC 157 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 SE+ +R+ + + A + +R TLV K N+++ T +++ ++A + Sbjct: 158 VYSEKEIERIGEMSFKAARSRNRKM-TLVDKANVLE-TSRLWREVIQKMALDY------- 208 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ ++ + D QIL+ P ++DVI N+ GD +SD + Sbjct: 209 -------------SDVDLEFLYIDNAAMQILINPRKFDVILTDNMFGDILSDEASILTSS 255 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 +G+ P A+IG + +LFE HG+ P+ G++ NP ILS MML + + +L+ + Sbjct: 256 LGLLPSASIGSKKSLFEPIHGSYPQAKGKNIANPLGCILSVSMMLEYFEMPQEKNLLEEA 315 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 ++ +I K T D ++D E GD I Sbjct: 316 VKSSIQEKICTPDI--ILDDRNSSSTEEVGDYI 346 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 108/416 (25%), Positives = 192/416 (46%), Gaps = 71/416 (17%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEK---AYKGERKISWMEIYTGEKS 74 N + + +I I DGIG +V PA ++V++AA+ K A + + + ++ + G ++ Sbjct: 23 NQQQIRLLSKVIGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWET 82 Query: 75 TQVYGQDVWLPAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPV 131 Q G+ LP ET++ ++ + AI G + +P G S VA+R+ +DLY +RP Sbjct: 83 FQKTGKS--LPVETVEALKNKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPC 140 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + + DM+I REN+E +Y E Sbjct: 141 QDLA---------KGIDMLIVRENTECLYIKKEKLTVDPTT------------------G 173 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDR---DSVTLVHKGNIMKFTEGAFKDWGYQL 248 E + + +E +KR+ A + A+ ++ VT+VHK N++ ++G F++ ++ Sbjct: 174 EKTAVADRLITERASKRIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEI 233 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 +++ ++ ++ + D+ + +++L P +YDV+ NL GD Sbjct: 234 SKKY--------------------PQVKTEEQLVDSMVYKMILDPTQYDVVVAPNLYGDI 273 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SDA +A VGG+G+ AN+ D AL E HG+AP G+ NP + I + M+LRH+ Sbjct: 274 LSDAGSAFVGGLGVTASANLSDSFALVEPVHGSAPDIFGKKISNPIATIRACAMLLRHLQ 333 Query: 369 W--------TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + KTVT D DAII+N+ Sbjct: 334 EKDPKCSYLNEIADSMDRAVNVVMPDKTVT-----TPDLGGKGNTETLVDAIIKNL 384 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 103/399 (25%), Positives = 155/399 (38%), Gaps = 58/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDG+G +V A KV+ A E G S+ +G+ + Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAE--VHGGLSFSFTAFPWSCDYYLEHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + + ++ G + P + L + +R+EL+L I +RP + G SP Sbjct: 60 PEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSP 119 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + HP D V+ RENSE Y+ + + D + I Sbjct: 120 LLHPNDFDFVVIRENSEGEYSEVGGRIHRGD--------------------DEIAIQNAV 159 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + T+R++R A E A R VT K N + + + Q A + G Sbjct: 160 FTRKATERVMRFAFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSG------ 212 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I DA + RP +DVI NL GD ++D ++ +G I Sbjct: 213 --------------IETSSQHIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSI 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GIAP ANI ++FE HG+AP AGQ NP I +A++ML H G E I+ Sbjct: 259 GIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ME T D +E D I + Sbjct: 319 DVMEQVTADGIKTRDI------GGQSTTAEVTDEICSRL 351 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 106/409 (25%), Positives = 170/409 (41%), Gaps = 68/409 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V PA L++V+AA A G + G L Sbjct: 6 DTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHN--AGAQYYAESGD--AL 61 Query: 85 PAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA TLD R+ + G + P G + LR EL L+ +RP+R++ G P Sbjct: 62 PASTLDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 141 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + P E D V+ RE +E ++ G +IR E Sbjct: 122 LTDPRAEQIDFVLVREQTEGLFYAR--------------------GRGEIRNDEE-AYDT 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + GT+R+ A + A R +VT V K N+ + + F+ ++A Sbjct: 161 MQITRSGTQRVTEFAFDIARQRKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVA----- 214 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 + ++ DA ++ +P +DV+ N+ GD +SD A Sbjct: 215 ---------------DRHSDLTKDHAYVDALALNMVKKPWTFDVLVTENMFGDILSDLAA 259 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG------ 368 +GG+G+AP A+IGD+ LF+ HGTAP AG+ NP ++ LSA MML + Sbjct: 260 GLIGGMGMAPSADIGDKHGLFQPAHGTAPDIAGKGCANPSAMFLSAAMMLDWLAAKFGQP 319 Query: 369 -WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA L+ +E ++ K M+ C+E ++I ++ Sbjct: 320 TLADAARLMEGAVEHTLSTK-----LAIPMEYGGNANCAEMTRSVISSL 363 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 323 bits (827), Expect = 1e-86, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 161/407 (39%), Gaps = 64/407 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDGIG++V P ++V++AA K + + E + +G+ + Sbjct: 4 HSFRIAAIPGDGIGLEVLPEGIRVLEAAALK-HGLALEFDTFE-WASCDYYLQHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + +++Y G + P + + R+E D Y+ +RPVR + G P Sbjct: 60 PDDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCA 119 Query: 141 V--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + D V+ REN+E Y+ + G+ I Sbjct: 120 LANRKVGDIDFVVVRENTEGEYSSLG-------------------GIMFENTENEIVIQE 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 + G R+++ A + A +R VT K N M + + +A Sbjct: 161 SIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHY------ 214 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA-CMNLNGDYISDALAAQV 317 + D + +L+P +DV+ NL GD +SD A Sbjct: 215 --------------PHVSWDKQHIDILCARFVLQPERFDVVVVASNLFGDILSDLGPACA 260 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----W 369 G IGIAP AN+ E +LFE HG+AP G++ NP ++I S +ML +G + Sbjct: 261 GTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDERY 320 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A D ++ +E I +VT D L + G AI + + Sbjct: 321 QRAHDDMLNAIERVIADGSVTPDM------GGTLSTQQVGAAISDTL 361 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 161/405 (39%), Gaps = 57/405 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG++V A L V+ A + G + + G+ V P Sbjct: 7 RKRICVLPGDGIGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGETV--P 57 Query: 86 AETLDLIREYRVAIKGPLTTP---------------VGGGIRSLNVALRQELDLYICLRP 130 A T +++ + G +T+ S + LRQ LDLY +RP Sbjct: 58 ARTWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRP 117 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 V G V+ REN+E +YAG+++ +++ + Sbjct: 118 VTDMTG-------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + + ++ + G R+ A EYA N VT V K +++ + + A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ DA ++ RP + VI N+ GD +S Sbjct: 231 RY--------------------PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILS 270 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370 D A +GG+G AP N G+ A FE HG+AP +AG +K NPG++ ++ +ML H+G+ Sbjct: 271 DLGAGVMGGLGFAPSGNFGNSGAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFP 330 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + I + + T TYD ++ G+AI++ Sbjct: 331 TESACISQAVSLVSRTSTRTYDL------GGSHTTAQVGEAIVQQ 369 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats. Identities = 113/398 (28%), Positives = 178/398 (44%), Gaps = 74/398 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I ++G+GIG ++T A ++V++A + W I +++ ++YG LP + Sbjct: 3 IGVLKGNGIGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQV 53 Query: 89 LDLIREYRVAIKGPL----------TTPVGGG---IRSLNVALRQELDLYICLRPVRYYQ 135 + I++ + IK PL T G S+N A+R+EL+L++ RP+R Y Sbjct: 54 IQRIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYV 113 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G E DMVI RE +ED Y G E + A + Sbjct: 114 GISG---RHEKMDMVIMREITEDTYIGWEKPLEDGAAAE--------------------- 149 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 IK + + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 150 -AIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVAR----- 203 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +IV D++ DA ++ P +DV+ +N GD SD A Sbjct: 204 ---------------LYPDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDIFSDLAAG 248 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 G +G+APGANIGD + FEA HG AP AG NP ++ILS +L H G+ + ++ Sbjct: 249 LAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHAGYGKGSEA 308 Query: 376 IVKGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAI 412 I + + I A T+T D + DAI Sbjct: 309 IREAVTRVIEAGRTLTPDL------GGRSTTEQVADAI 340 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 320 bits (820), Expect = 7e-86, Method: Composition-based stats. Identities = 107/406 (26%), Positives = 169/406 (41%), Gaps = 73/406 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + +GDGIG ++ A + ++A I W ++ G ++ Q G V++ Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNTG--VYI 82 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICLRPVRYY 134 +D E V KGPLT P S N R+ L+ +RPVR Sbjct: 83 DDSHMDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSM 142 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G +P D+V+ REN+ED+Y G E D+ Sbjct: 143 PGVRAPF---NDVDLVVIRENTEDVYTGEETWVDADTVH--------------------- 178 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 +K S ++R+ + +YA N R VT +HK N+ K ++G F + ++ A Sbjct: 179 --CVKRISRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAA---- 232 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 I+ D +AD+ L ++++ P +DV+ C NL GD ++ Sbjct: 233 --------------ATDLGGIIADDQLADSCLTKLMIEPKSFDVLCCPNLYGDLVNPLSL 278 Query: 315 ----AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370 VG +G+ P NIG ALFE HG+AP AG+ NP S ILS MML H+G Sbjct: 279 RINRGMVGSLGLCPSGNIGTHQALFEPAHGSAPDIAGKGIANPTSQILSGCMMLSHLGEF 338 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EA+ + + + V DF E A+++++ Sbjct: 339 EASQRLENALRAMYASGIVPVDF------GGQADTKEVVAAVLKHL 378 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 94/397 (23%), Positives = 168/397 (42%), Gaps = 64/397 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 V + + + GDG+G ++ A+ +V AA E +S ++ E+ + Sbjct: 45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLE------ 98 Query: 83 WLPAETLDLIREYRVAIKGPLTTPV--GGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G Sbjct: 99 ----QVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGY--- 151 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+VI RE +E Y+ +E ++ E +K Sbjct: 152 MTRHNNLDLVIIREQTEGEYSSLEHESARGVIE-----------------------CLKI 188 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + ++R+ + A +YA R VT VHK NIMK +G F ++A Sbjct: 189 VTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVA----------- 237 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I + +I D Q++ P ++DV+ NL G+ I + A VGG Sbjct: 238 ---------ELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGA 288 Query: 321 GIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ PG + E A+FE + G++ NP +++LSA MLRH+ + +I Sbjct: 289 GVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ I R D ++F ++I ++ Sbjct: 349 VKKVIKVGK-----VRTRDMGGYSTTTDFIKSVIGHL 380 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 101/401 (25%), Positives = 175/401 (43%), Gaps = 43/401 (10%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + +P I GDGIG +V KV+ AA E + W+++ G+ + Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQE---VYNFDVEWIDMPFSADHYVKTGET--IS 57 Query: 86 AETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +L + +YR G + G + + + +R D Y+ LRPV+ +G +P+ Sbjct: 58 ESSLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPL 117 Query: 142 KHPE--LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCG 195 K D + REN+ED Y GI ++ +++ ++ +R+ + G+ + Sbjct: 118 KGKTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIA 177 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + S+EG KR++ + + A + + ++ V K N++ G +++ A + Sbjct: 178 YQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKY--- 234 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ DA + P +DV+ N+ GD I+D A Sbjct: 235 -----------------PDVKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAM 277 Query: 316 QVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+APG NI E ++FE G+APKY G +KVNP + I + M+L H+G +AA Sbjct: 278 IQGGLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGEKQAAA 337 Query: 375 LIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 IV +E + K TYD S+ G I Sbjct: 338 GIVDAIEQNLKEKKIRTYDL------GGSAGTSDVGTDIAR 372 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 107/399 (26%), Positives = 178/399 (44%), Gaps = 41/399 (10%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +VT +KV++AA + G + Q L Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAGS---LFGFSLELTHYPYGAEHYLSTRQ--VL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P L+ + + G + P G R + + LR D Y +RPVR + TP P+ Sbjct: 57 PDHALEEMEGLDALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSF--TPGPL 114 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI----KFLREEMGVKKIRFPEHCGIG 197 + V+ REN+ED+Y GI D A + ++ + P+ + Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYES--- 228 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + ++ DA +++ P ++ VI C N+ GD +SD LA Sbjct: 229 -----------------VSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIG 271 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP N+GD ++FE HG+AP AGQD+ NP + ILS M+LRH+G T AA + Sbjct: 272 GGMGLAPSGNVGDRLSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETSAAKAME 331 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ ++ E ++ L GDA++ + Sbjct: 332 DAVQRYLSGPV----EELPIEMGGRLGTRGAGDAVVRRL 366 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 101/403 (25%), Positives = 163/403 (40%), Gaps = 66/403 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI-YTGEKSTQVYGQDVWLPAE 87 I I GDGIGV+V P L+ +DA + + ++ I + +GQ +P + Sbjct: 43 IAVIPGDGIGVEVMPEGLRALDAVSRR---FGLRFAYEPIEWASCDYYAKHGQ--MMPDD 97 Query: 88 TLDLIREYRVAIKGPL----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV-- 141 + + G + T P + + R+E D Y+ LRP R + G P P+ Sbjct: 98 WKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAG 157 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + D +I REN+E Y+ A + + E V++ Sbjct: 158 RKAGDIDFMIVRENTEGEYS--------AVGGTMFEGTEREFVVQQA-----------VF 198 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + GT+R+++ A E A +T+ K N + + + ++A Sbjct: 199 TRHGTERVLKFAFELAQRRA-KRLTVATKSNGIAISMPWWDARAAEMAARY--------- 248 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++ D + +++P +DV+ NL GD +SD A G IG Sbjct: 249 -----------PDVAWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIG 297 Query: 322 IAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----WTEAA 373 IAP AN+ E +LFE HG+AP AG+ NP ++I SA MM+ +G EA Sbjct: 298 IAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPAREAH 357 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D IV +E + T D E GDAI+ ++ Sbjct: 358 DAIVAAIEHVLKHGPRTRDM------GGRASTREVGDAIVAHL 394 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 99/404 (24%), Positives = 161/404 (39%), Gaps = 59/404 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V V+ A + + E+ G + + G V L Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGS---LEGLEFDFKEMPVGGAALDLVG--VPL 99 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA------LRQELDLYICLRPVRYYQ--- 135 P ET + + G + LR++L ++ LRP Sbjct: 100 PEETFTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLV 159 Query: 136 -GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 + + E DM+I RE + IY G E G+ E Sbjct: 160 DASTLKKEVAEGVDMMIVRELTGGIYFG------------------EPRGITINENGEEV 201 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 G+ + + R+ R A E A R + V K N++ + ++ LA E Sbjct: 202 GVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDAS-ILWRKRVTALASEY-- 257 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ + + D Q++ P ++D I N+ GD +SD + Sbjct: 258 ------------------PDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEAS 299 Query: 315 AQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G IG+ P A++G+ LFE HG+AP AGQDK NP + ILSA M+L++ +G +A Sbjct: 300 MITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKA 359 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I + A+N T D G KL+ C E G+ +++++ Sbjct: 360 AKRIEDAVVDALNKGFRTGDIYSP--GNKLVGCKEMGEEVLKSV 401 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 317 bits (812), Expect = 5e-85, Method: Composition-based stats. Identities = 103/400 (25%), Positives = 158/400 (39%), Gaps = 61/400 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + I GDGIGVDVT +KV+D+A +I W E + G Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA------TGGRIEWTEFDYSCERYAKTG--A 52 Query: 83 WLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + + G + P + L + LR+ + Y+ LRPVR G S Sbjct: 53 MMPPDAPTTLAGFDAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIAS 112 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ E MVI REN+E Y+ I GV + Sbjct: 113 PLAGVSDEALSMVIVRENTEGEYSPIG-------------------GVHNRGNQNEFALQ 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G +R++R A E A + V K N + + + ++A E Sbjct: 154 ESVFTRIGCERIIRYAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEY----- 207 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + DA +++ PA DVI NL GD +SD AA Sbjct: 208 ---------------PQTPSVSMHVDALAARMVSDPASLDVIVASNLFGDILSDLAAAIT 252 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+A NI E ++FE+ HG+AP AGQ NP + IL+ M+L H+ A+ Sbjct: 253 GGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQILAGAMLLDHLNEPATAN 312 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 I ++ ++ V R D + G AI E Sbjct: 313 KIRLAVDQVLSDGRV-----RTPDLGGTATTEQLGTAIAE 347 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 316 bits (811), Expect = 7e-85, Method: Composition-based stats. Identities = 100/402 (24%), Positives = 166/402 (41%), Gaps = 59/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG ++T + ++V++ EK G +S+ G + +G LP Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLG---LSYTYKDAGGTAYDKFGTP--LP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-- 137 +T++ + + G + + + LR+ L LY LRPV+ Sbjct: 57 DDTIEACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVE 116 Query: 138 PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K + D+VI RE IY G + +++ + Sbjct: 117 YSPLKPELVKGVDLVIVRELIGGIYFGDKCESEQHNGA-------------------ERA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 ++ S R+ + A E A R VT V K N++ T ++ ++A Sbjct: 158 WDLENYSVPEVDRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESY--- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + ++ D Q+ +RP ++DVI NL GD +SD A Sbjct: 213 -----------------PDVELNNLYVDNCAMQLAIRPTQFDVIVTGNLFGDILSDEAAV 255 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G IG+ P A+IG +L+E HG+AP AG+ NP ILSA M+LR+ + AA Sbjct: 256 VGGSIGMMPSASIGTSTSLYEPIHGSAPDIAGKGIANPMGTILSAAMLLRYSLHEEAAAK 315 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I ++ A+ T D + +G + E I E + Sbjct: 316 AIEAAVDKALADGYRTPDLWK--EGFQKANTEEITKVICERI 355 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 102/398 (25%), Positives = 175/398 (43%), Gaps = 62/398 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 +EGDGIG ++ A + V+ AA+ K Y + + + EI G S + + +E L Sbjct: 8 VLEGDGIGPEIAKASVDVLQAAL-KLYDLKVNLVYEEI--GFASLKKH--KTTFRSEVLK 62 Query: 91 LIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + + I G P G + + +R+ DLY +RP + G + P Sbjct: 63 IAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLG--KLERFPMG 120 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D ++ REN+E Y+ GV ++ I I+ + +G+ Sbjct: 121 IDCLVMRENTEGFYSDR----------------NMFKGVGELMPTPDVAISIRNITRKGS 164 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 R+ +YA+ R + +HK N++++++G F + Q++++ Sbjct: 165 TRIAEIGFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKY-------------- 209 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 E+ K+ I D+ ++ P+ +DVI NL GD +SDA + GG+G+A Sbjct: 210 ------PEVEYKEQIVDSMSAMLIRDPSVFDVILATNLFGDNLSDAASEIAGGLGLAESI 263 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------WTEAADLIVKG 379 N G+ + +A HG+AP AG++ NP S+I S MML +G E A +I Sbjct: 264 NAGENYCIAQAQHGSAPDIAGKNIANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDA 323 Query: 380 MEGA-INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ IN KT T D L ++F D +I N+ Sbjct: 324 IDKTIINPKTRTSDI------GGNLSTTDFTDVLISNL 355 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 315 bits (806), Expect = 3e-84, Method: Composition-based stats. Identities = 87/373 (23%), Positives = 149/373 (39%), Gaps = 53/373 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG DVT A +V+ + ++ + G + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHS---GFTLTATPFPWSCAFYKETG--AMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PPDGIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + A++V + Sbjct: 117 LK-AEGFDILCIRENTEGEYSGAGGRVHQGTADEV-------------------AVETSI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R + A R + V K N K++ + + +LA E Sbjct: 157 FTRTGVERILRFGFDQARQRRRK-LASVTKSNAQKYSMVLWDEITRELAAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+ NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVVASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G AA ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLDHLGQARAARKVI 315 Query: 378 KGMEGAINAKTVT 390 + +E T Sbjct: 316 EALERTTARGIGT 328 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 314 bits (805), Expect = 4e-84, Method: Composition-based stats. Identities = 101/393 (25%), Positives = 167/393 (42%), Gaps = 71/393 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I+GDG+G ++ A L +++ + ++EI G+ G+ + Sbjct: 3 IAVIKGDGVGPEIMGATLSLLERYIGA--------DFIEIKAGKSYFIEEGKP--IEDNA 52 Query: 89 LDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 ++ IRE +KGP+ TP G S+N LR+E LY +RP R Y+G Sbjct: 53 IEKIRECDSLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISI-----RRI 107 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D ++ REN E +Y G E + E I ++ ++ G + Sbjct: 108 DTILVRENLECLYYGWEVE------------------------DEDRAIAMRVITKRGAE 143 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A A R VT +HK NI+K T+G F D Y++A Sbjct: 144 RISEFAFNLAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVA------------------ 185 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + ++ D I DA +++ +DV+ NL GD +SD A VG IG+ A Sbjct: 186 ---SKFDLRADDEIVDAAGYKLVKLDNAFDVMLTPNLYGDILSDVAAGVVGSIGLCGSAQ 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW----TEAADLIVKGMEGA 383 IG++ A FE HGT AG+ NP +I++A MML + + + I + ++ Sbjct: 243 IGEDFAAFEPIHGTGEDIAGKGVANPIGMIIAASMMLDWLWERGRSPKRGEKIREAVDSV 302 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +T D + + + I++ + Sbjct: 303 IRDRILTPDL------GGDFRTEQVVEKIVDRL 329 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 314 bits (804), Expect = 5e-84, Method: Composition-based stats. Identities = 105/400 (26%), Positives = 170/400 (42%), Gaps = 62/400 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GD IG ++ P ++V+ AA + I W +I G + G LP Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAART---GLAIEWQDIPIGRAALDSLGST--LPDG 56 Query: 88 TLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 T++ + + GP+ P + + LR+ DL+ +RPV+ + P Sbjct: 57 TIERLDALDGWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---H 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E ++ D G + R I ++ + Sbjct: 114 QGVDLVIVRENNEG------FQPDRNVVA----------GSGEFRPTPDVTISVRVITRN 157 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G+ ++ RAA E A A R +T VHK + K G F + +LA E Sbjct: 158 GSSKVARAAFELARARRR-HLTAVHKDTVFKLGCGMFAEECRRLAAEY------------ 204 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + I D F ++++ P YDV+ N+ GD ++D A VGG+G+A Sbjct: 205 --------PDVTYDEAIVDTFAMRLVMTPQRYDVVVTTNMFGDILTDEAAGLVGGLGMAA 256 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLIV 377 G G A+ +ATHG+AP AG+ NP ++I+S +M+L +G AA LI Sbjct: 257 GLCAGPRHAMAQATHGSAPDIAGRGIANPYAMIMSGQMLLDWLGRRHAEPAATAAARLIE 316 Query: 378 KGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + I + +T D + G AIIE M Sbjct: 317 QAVANMIEERRALTPDL------GGQGTTAGMGSAIIEAM 350 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 100/411 (24%), Positives = 164/411 (39%), Gaps = 62/411 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I + GDGIG++VT A L V + I W + Sbjct: 1 MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAA------ 54 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLY 125 +P+ T LI + G +T+ S + LRQ LDL+ Sbjct: 55 ---IPSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLF 111 Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 +RP P + I RENSE +Y G ++ K I L E Sbjct: 112 ANVRPCFSIDDQSKPF------NFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQH 161 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + + ++ S+ G RL A ++A+ VTL K N+++ + G F Sbjct: 162 WQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRES-GEFTRKI 220 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 ++ + P +I + DA ++ P ++ VI N+ Sbjct: 221 FE---------------STAQRYPKIQADI----LNVDAVALWLIKSPEKFGVIVAENMF 261 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GD +SD A +GG+G+AP ANIGD+ + FE HG+ P+ ++ NP ++ L+ M+L Sbjct: 262 GDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRIR-KNCANPSAMFLTISMLLN 320 Query: 366 HMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIEN 415 H G+ + A IV + I K +TYD ++ +A+IE+ Sbjct: 321 HFGYPDRAKKIVNAVMQVIKEKRFITYDL------GGHATTTDMANAVIEH 365 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 95/400 (23%), Positives = 158/400 (39%), Gaps = 68/400 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG +VT A LKV+ A E G +++ G + +G+ P Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDEAEGLG---LAYEVFPFGGAAIDAFGEP--FPEP 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTP--S 139 T + E + G + P G+ + ++LR+ DL+ LRP + + G S Sbjct: 57 TRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLS 116 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K D++I RE + IY G A+A Sbjct: 117 PLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEA-----------------------WN 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + S+ +R+ R A E A R V V K N+++ E ++ ++ R Sbjct: 154 TERYSKPEVERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ ++ DA ++ PA +DV+ N+ GD +SD + Sbjct: 207 ---------------PDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLP 251 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLI 376 G +G+ P A++G +FE HG+AP AG+ NP + ILSA MML H G E A + Sbjct: 252 GSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKV 311 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ D F ++ ++ Sbjct: 312 EDAVAKALLE-------TPPPDLGGSAGTEAFTATVLRHL 344 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 95/393 (24%), Positives = 156/393 (39%), Gaps = 56/393 (14%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL 89 I GDGIG +V A + + AA+E ++ G + G +P + Sbjct: 11 AVIPGDGIGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAMPPDAA 65 Query: 90 DLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 DL+++ + G + P L + LRQ+LDL + LRPVR + G P+ V+ + Sbjct: 66 DLVKKTDAVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDTDG 125 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN+E Y G GV GI + S Sbjct: 126 VDLVIVRENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRRAI 166 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R A A + LV K N M++ + ++ + Sbjct: 167 ERAAHQAFALAGRRS-GRLCLVTKSNAMRYGYPLWDRVVREVGEQY-------------- 211 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + ++ V+ DA +++ P DV+ NL GD +SD A GG+G+AP A Sbjct: 212 ------PGVELETVLVDAMAARMIQAPRSLDVLLASNLFGDILSDLAAVLAGGMGMAPSA 265 Query: 327 NIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N+ + ++E HG+AP AG+ NP + +LS M+L +G T+AA + + Sbjct: 266 NVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLLSGAMLLEDLGHTDAARRVRDAVADT 325 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D ++ A++ M Sbjct: 326 LRDTRH-----HTADLGGNATTADVASAVLHTM 353 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 169/401 (42%), Gaps = 55/401 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P++ + + GDGIG +V +++++ E ++ + GE Q G+ Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE--YQRSGE-- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 LP D + G + P G + + LR+ L LY +RP+R Y Sbjct: 57 ALPQSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEAD 116 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 +P+K P D V+ RE++E ++ G + AD Sbjct: 117 TPLKGHGPGEIDFVLVRESTEGLFYGRDAIAD---------------------LEADEAT 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + ++R+ R A E A + +VTL+ K N++ + F+ ++A+E Sbjct: 156 NLLRITRSASERVCRLAFETARRRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFL-- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I + V DA ++ RP ++DV+ N+ GD +SD A Sbjct: 213 ------------------DIKAEHVYVDAAALFLVRRPQDFDVMVTENMFGDILSDLAAG 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+AP +IGD+ A+F+ +HG+AP AGQ NP ++ LS MML + E Sbjct: 255 LVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMMLEWLDHPET--R 312 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A A ++ +R D L E D I E + Sbjct: 313 RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAERL 353 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 101/390 (25%), Positives = 168/390 (43%), Gaps = 66/390 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P I I GDG+G ++ A++ V++ + + G+++ + G V LP Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSD---LMNLPLDLRFFEAGDETKRKRG--VALPE 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ETL+ + + + G R + + LRQ+LDLY+ LRP + Y + Sbjct: 57 ETLNGVMNSDATLMVAI----GESAREVILPLRQKLDLYVNLRPAKSYP----VPRAIPG 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+ I REN+ED+Y W+ + ++ + + Sbjct: 109 FDLTIVRENTEDLYVMSGWR------------------------GLDTAVDLRIITRRAS 144 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R YA + V +VHK N++ F++ ++A EE Sbjct: 145 ERICRFGYRYARERGKSRVYVVHKANVLG-GCMLFREVCSRVAEEEGFD----------- 192 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +++ D+ +I + +DVI N+ GD +SD AA +GG+G+ P A Sbjct: 193 ----------YREMYVDSAAMRIAMD-RPFDVIITTNMFGDILSDLAAAFIGGLGMYPSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+ A+FE HGTAP+ AG++ NP + ILSA MM+ +G + LI + + A Sbjct: 242 NIGESRAIFEPVHGTAPEIAGKNIANPMATILSAAMMMGWLGHEGGSKLIEEAVRRACEL 301 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D ++ E G I E M Sbjct: 302 GYTTPDV------GGSMRTKEVGLKISEIM 325 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 310 bits (794), Expect = 6e-83, Method: Composition-based stats. Identities = 101/393 (25%), Positives = 164/393 (41%), Gaps = 63/393 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G +V K +DA E I+W ++ G +G +PA+ Sbjct: 3 VVLLPGDGVGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADA 53 Query: 89 LDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KH 143 +D++R + + G + P + L + +RQELDL++ +RP R +G P P+ + Sbjct: 54 IDVLRGHDAILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRA 113 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 P DMV RENSE YAG+ + F I + Sbjct: 114 PHDVDMVFVRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFTR 154 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R++R A A A + + K N +F + + ++ E Sbjct: 155 RGCERVIRYAFGMASAR-KGVLVNATKSNASRFGFPFWDEIVAEVGAE------------ 201 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 +V+ ++ DA +++ P DV+ NL GD ++D AA GG+G+A Sbjct: 202 --------FPGVVVDRMLVDALSARLIRDPGSVDVVVASNLFGDILTDIAAALQGGMGMA 253 Query: 324 PGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 AN+ ALFE HG+AP AG+ NP I SA +ML +G E + ++ + Sbjct: 254 ASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSAALMLEQLGAGEGSRRLMDAL 313 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E T D +E GDA++ Sbjct: 314 ETVCRRGPRTRDV------GGTATTAEVGDAVV 340 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 90/389 (23%), Positives = 160/389 (41%), Gaps = 71/389 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I G GIG ++T ++ V +A I + V + ++ Sbjct: 35 VTLIPGVGIGPEITNSVKTVFEAL-------HVPIKF----------DVLDNFNFENDDS 77 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 +R+ + G + T N + LDLY + +G + TD Sbjct: 78 KSQLRKNECILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNNTD 132 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+E Y+G+E + E IK +++ + R Sbjct: 133 IVVIRENTEGEYSGVEHEVYPGVVE-----------------------SIKVTTKQASLR 169 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + A E+A + R VT VHK NIMK +G F ++A+ Sbjct: 170 IAEYAFEFAHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSF-------------- 215 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 I +++I D Q++ P ++DV+ NL G + + +A GG+G+A GA+I Sbjct: 216 ------IKYEEMIIDNCCMQLVKNPTQFDVMVMPNLYGSIVQNVVAGITGGVGMAAGASI 269 Query: 329 GDECALF-EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 G + ALF + T AG++ VNP ++++S+ ++LRH+G AD I + ++ I K Sbjct: 270 GKDHALFSQGCRHTGRDIAGKNVVNPSAMLVSSTLLLRHLGLPNFADQICRAVQHTIQDK 329 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D +F +I ++ Sbjct: 330 KI-----KTKDIGGNATTDQFTSEVIRSL 353 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 163/404 (40%), Gaps = 63/404 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + + GDGIG +V L+V+ AV + + + G GQ Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP----ADVSLDTTQYPFGAGHFLETGQ-- 54 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 L L + ++ + G + R L + LR D YI LRP Sbjct: 55 ILTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLP 114 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G SP+ P D V+ RE +E YAG GV + Sbjct: 115 GVASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIA 155 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + G +R VR A E A DR VTLVHK N++ F ++ ++A E Sbjct: 156 TEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEH--- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + DA + ++ P+ +DVI NL GD I+D AA Sbjct: 213 -----------------PDVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAA 255 Query: 316 QVGGIGIAPGANIGDECA---LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 GGIG+A N+ A +FE HG+AP AGQ K +P + ILS ++L H+G +EA Sbjct: 256 ISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEA 315 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + + A R A +E GDAI+ + Sbjct: 316 AARVSAAVSDDLAA--------RATGDAAPRSTAEVGDAILRAL 351 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 308 bits (789), Expect = 3e-82, Method: Composition-based stats. Identities = 89/362 (24%), Positives = 154/362 (42%), Gaps = 54/362 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I GDGIGVDVT A ++V+ AA + G + +G+ + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAAK----GRFAFDTTSFPWSCEYYLEHGR--MM 55 Query: 85 PAETLDLIREYRVAIKGPL----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + G + T P + L + +R+ + Y +RP R G P Sbjct: 56 PEDGIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGP 115 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + +V + Sbjct: 116 LK-AEGFDILCIRENTEGEYSGAGGRVHEGKGNEV-------------------AVETSV 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R E A + R +T V K N K++ + + +LA E Sbjct: 156 FTRAGVERILRFGFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEY-------- 206 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + + DA ++++ P + DV+ NL GD ++D AA GG+ Sbjct: 207 ------------PDVTVSHMHIDAMAAKMVMAPQDLDVVVASNLFGDILTDLGAAIQGGL 254 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP AG++ NP + I S ML H+G E + ++ Sbjct: 255 GFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAIWSVAQMLDHLGEAEVSAAVL 314 Query: 378 KG 379 Sbjct: 315 SA 316 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 306 bits (785), Expect = 7e-82, Method: Composition-based stats. Identities = 89/396 (22%), Positives = 160/396 (40%), Gaps = 64/396 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDG+G +V + +V+ VE+ Y + Y G + + GQ LP T Sbjct: 5 IVCLAGDGVGPEVMESAKEVLH-MVERLY--GHHFHLQDEYFGGVAIDLTGQP--LPQRT 59 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSL----NVALRQELDLYICLRPVRYYQGTP--SPVK 142 L + G + P + +ALR+ L ++ +RPV T SP+K Sbjct: 60 LAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + + D V+ RE + IY + A + + R E Sbjct: 120 NADEIDFVVVRELTGGIYFSYPKERTEEVATDTLTYHRHE-------------------- 159 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +R+V A + A + VT + K N+++ + ++ ++A Sbjct: 160 ---IERIVSYAFQLANKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRY---------- 204 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 + ++ ++ DA +++ P +DVI NL GD +SD + G +G+ Sbjct: 205 ----------PNVEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGM 254 Query: 323 APGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADLIVKGM 380 P A+ ++ +L+E HG+AP AG++K NP +++ S MML + G T I + + Sbjct: 255 LPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEEAV 314 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + F A+I+ M Sbjct: 315 SAVLKSGKCTADI------GGTETTTSFTKAVIQEM 344 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 306 bits (784), Expect = 9e-82, Method: Composition-based stats. Identities = 91/398 (22%), Positives = 167/398 (41%), Gaps = 66/398 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG ++ L +++ K Y +I E G S +G+ L +T Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LTEKT 59 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSL----NVALRQELDLYICLRPVRYYQGTPS--PVK 142 L+ + + G + P + + LR+ L+L+ +RP +G S P+K Sbjct: 60 LNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 143 --HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E TD+VI RE + IY G ++ +A + + Sbjct: 120 AERVEGTDLVIVRELTSGIYFGEPRYFNNHEALDSLTY---------------------- 157 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + E +R+V A + A A+ R +T V K N++ + ++ ++++ Sbjct: 158 -TREEIERIVHVAFKLA-ASRRGKLTSVDKENVL-ASSKLWRKVVNEVSQ---------- 204 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 E+ + ++ DA ++ P ++DVI NL GD +SD + G + Sbjct: 205 ----------LYPEVTVNHLLVDACSMHLITNPKQFDVIVYENLFGDILSDEASVIPGSL 254 Query: 321 GIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVK 378 G++P A+ ++ L+E HG+AP AG++ NP +ILS M LR + +AAD + + Sbjct: 255 GLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADELEQ 314 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I T D L ++ + + + + Sbjct: 315 HIYNMIEHGQTTADL------GGKLNTTDIFEILSQKL 346 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 306 bits (784), Expect = 1e-81, Method: Composition-based stats. Identities = 111/390 (28%), Positives = 178/390 (45%), Gaps = 67/390 (17%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG--QDVWLPAE 87 ++GDGIG +V +ML+V+ + + G + G ++P Sbjct: 6 AVMKGDGIGPEVVDSMLRVLKEC-------NFQSELILCEAGSEQWDKNGRKDASYIPDV 58 Query: 88 TLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 T+ ++ E KGP TT PV G RS+ V LRQ+ DLY +RP + Y + Sbjct: 59 TMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYD----RLTPDRK 114 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D V FRE +E +Y G+E + + I I+ + +G+ Sbjct: 115 LDCVCFREATEGLYTGVE-----------------------AKITDDAAIAIRKITRQGS 151 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +RL+ +A+++A + + V K NI+K T+G F W + Sbjct: 152 RRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGIF---------------------WDET 190 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAP 324 + G +I + ++ D QQ+++ +++ V+ NL D IS+ +A VG IG+ Sbjct: 191 QKAVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELASALVGSIGLIY 250 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIGD A+FEA HG+AP++AGQ+KVNP + +LS M ++G + D I E I Sbjct: 251 SANIGDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMADYLGERDVRDAIFAATEQVI 310 Query: 385 NAKT-VTYDFERLMDGAKLLKCSEFGDAII 413 N VT+D ++ DAII Sbjct: 311 NEGKAVTWDI------GGDASTTQMTDAII 334 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 306 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 112/400 (28%), Positives = 170/400 (42%), Gaps = 63/400 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ A ++V+DA E + R ++EI G + + G V Sbjct: 6 IGLIRGDGIGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTG--VACAEAD 62 Query: 89 LDLIR-EYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +R E +KGP+ TP G L LR LD Y +RPVR + G PS V+ Sbjct: 63 VRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRVR 122 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D VI REN+E +YA + + Sbjct: 123 -ADRVDYVIVRENTEGLYASRGKGVGN----------------------RWAVTDTLLTT 159 Query: 203 EEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 EGT R+ R A A VT V K N+++ + F++ ++A E Sbjct: 160 REGTLRVARKAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAE----- 213 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 E+ ++ ADA Q ++L P +DV+ N GD +SD A Sbjct: 214 ---------------FPEVELEYRYADAAAQDLVLCPERFDVLVMENFLGDVLSDLGGAT 258 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 VGG+G+ P N+GD A FE HG+AP G+++ NP +L+A M+L H+G + A + Sbjct: 259 VGGVGLCPAGNVGDGAAYFEPVHGSAPDLVGRNRANPVGQLLAAAMLLDHLGHVDEAARL 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + TV + DG L DA+I + Sbjct: 319 RRAVSAVLAFGTVRIE----ADGTVLGGAEAVADAVIAAL 354 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 306 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 77/402 (19%), Positives = 160/402 (39%), Gaps = 64/402 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG +++ ++V+ A EK K+++ G + G P Sbjct: 2 DFKIAVLAGDGIGPEISVQGVEVMSAVCEK---FGHKVNYEYAICGADAIDKVGDP--FP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT- 137 ET + + + + P +A+R++L L+ +RPV+ ++ Sbjct: 57 EETYRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLV 116 Query: 138 -PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D + RE + +Y G +++ Sbjct: 117 HKSPLRAELVEGADFLCIRELTGGMYFGEKYQ------------------------DNDK 152 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 153 AYDTNMYTRPEIERILKVGFEYAMKR-RKHLTVVDKANVL-ASSRLWRQIAQEMAPQY-- 208 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 E+ + D +++ P +DV+ N GD ++D + Sbjct: 209 ------------------PEVTTDYMFVDNAAMKMIQEPKFFDVMVTENTFGDILTDEGS 250 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+ P A+ G+ +FE HG+ P+ G + NP + ILS M+ + Sbjct: 251 VISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYFDCKAEGA 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LI K ++ +++A T + + ++G + E G I++ + Sbjct: 311 LIRKAVDASLDANVRTPEIQ--VEGGEKFGTKEVGAWIVDYI 350 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 100/395 (25%), Positives = 160/395 (40%), Gaps = 50/395 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + DGIG ++ A ++V+ +A + +K + + ++ G S + YG L E Sbjct: 3 ILVLPCDGIGPEIVGAAMEVLRSA-DSVFKLDLAFDYDDV--GFTSLEKYG--TTLRDEV 57 Query: 89 LDLIREYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L + Y I G + P GG R+++ R LDLY +RP R S ++ Sbjct: 58 LAKAKTYDGVILGTQSHADYPAPDKGG-RNVSAGFRIGLDLYANVRPARTRPFLTSNMRE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI RE +E Y A+ + I ++ + Sbjct: 117 GRTMDLVIMREATEGFYPDRNMTKGWAE----------------LMPSPDMAISLRKITR 160 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 ++R+ R A E A+ + VT +HK N T+G F + +AR+ Sbjct: 161 HCSERIARRAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARD------------ 207 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 E+ + D++ DA ++ P +DV+ N GD ISD + G +G+A Sbjct: 208 --------FPEVRLDDLLIDASTAHLVRAPERFDVLVATNFYGDIISDLASELSGSLGLA 259 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA--ADLIVKGME 381 D +A HG+AP AGQDK NP S+ILS M+++ MG A L Sbjct: 260 GSMMASDTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQWMGEHHQNPAYLAAAQAM 319 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + R D C FG + + + Sbjct: 320 EAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKVI 354 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 106/397 (26%), Positives = 170/397 (42%), Gaps = 62/397 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIGV+V K+ + I + G + G+ V P Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGKVV--P 60 Query: 86 AETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +D +++Y + G L P + +RQ+LD ++CLRP +++ G P+P+K Sbjct: 61 IDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLK 120 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+++ RENSE Y+ I G+ K P+ I + Sbjct: 121 KCE-IDILVVRENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHT 160 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R A E A R+ VTL K N MK+ + +A E Sbjct: 161 RRGLERVIRYAFE-ASRKRRNHVTLATKSNAMKYGMVLWDSVFEAIAMEY---------- 209 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + DA +I+ P+++DVI NL D ISD G +GI Sbjct: 210 ----------PDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDIISDLTVTVAGSMGI 259 Query: 323 APGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 AP ANI E +LFE HG+A AG+ +P + ++ MML +G++E + LI + Sbjct: 260 APSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASSMMLEFLGYSEESVLIEEA 319 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +I K T D +E G+ I + + Sbjct: 320 IQSSILQKITTIDI------GGTKTTNEVGNFIADYI 350 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 305 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 122/420 (29%), Positives = 193/420 (45%), Gaps = 70/420 (16%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 V+ AQG + Q + II GDGIG +T ++++ + K + K+ + Sbjct: 26 VMKAQGDFLNYQ-----ALDKIIIGVCGGDGIGPAITSQAQRILEYLL-KDDILQGKVEF 79 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQE 121 I G + + +PAE L ++E V +KGP TTP G + S NVA+R+E Sbjct: 80 KVID-GLTIERRAAEHAAIPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKE 138 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDL+ +RPVR + + D +REN+E YA Sbjct: 139 LDLFANVRPVRIPE---------QGIDWTFYRENTEGAYA-------------------- 169 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +G K I E G+ + G++R++RAA EYA AN + VT V K NI+K T+G F Sbjct: 170 -VGSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDGKF 228 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQIL--LRPAEYDVI 299 D ++A++ K+I D D +++ R ++ V+ Sbjct: 229 LDIFREIAKDY--------------------KDITADDWYIDIMTAKLIDEKRRKDFQVM 268 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD I+D A GG+G A ANIG ++FEA HG+AP+ + + +P S+ Sbjct: 269 VLPNLYGDIITDEAAEFQGGVGTAGSANIGKRYSMFEAIHGSAPRMVQEGRDQYADPCSV 328 Query: 357 ILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + M+L H+G+ + AD + + ++ TVT + +EF D I+E + Sbjct: 329 IRAGAMLLAHIGYGKEADKLYQALDIC----TVTEKKLVITGRNTGATGAEFADYIMETI 384 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 86/402 (21%), Positives = 151/402 (37%), Gaps = 62/402 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 N I + GDGIG + T + K+++ + + + I E G + G Sbjct: 3 NNYHIAVLPGDGIGPETTRQVYKILNVIKK---QFQINIVTTEHKIGGDAINSEGTP--F 57 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQGT 137 P TL + + G + P ++ +ALR+ +L+ LRP+ Sbjct: 58 PKSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADEL 117 Query: 138 P--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 SP+ P D++ RE + IY G Sbjct: 118 KELSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLN------------------- 158 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +R+ A + A R V+ + K N++ T +++ LA+ Sbjct: 159 EYAFDTAVYHRFEIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAKNY 216 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 ++ ++ + D Q++ P+++D+I C NL GD +SD Sbjct: 217 --------------------PDVELEHLYIDNASMQLINNPSKFDIILCPNLFGDILSDE 256 Query: 313 LAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 A G IG+ P A+I + L+E G+AP A ++ NP + ILS ++ R+ + Sbjct: 257 CAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIAHILSIALLFRYSLKLD 316 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 A I K + A+ T D + + K + +E GD I Sbjct: 317 HIAIKIEKAVSQALMLGYRTIDIAKKHE--KSISTNEMGDII 356 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 304 bits (778), Expect = 4e-81, Method: Composition-based stats. Identities = 87/371 (23%), Positives = 148/371 (39%), Gaps = 53/371 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG DVT A V++ + A G + G + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENGS--MM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA+ ++ ++ + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PADGIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 ++ + D++ REN+E Y+G + I Sbjct: 117 LRS-DGFDILCIRENTEGEYSGAGGRIHQG-------------------ADNEVAIETAI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +G +R++R E A A R + V K N K++ + + + L+ E Sbjct: 157 FTRKGVERILRFGFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+A NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVAASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G T AA+ ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLEHLGETAAAEKVM 315 Query: 378 KGMEGAINAKT 388 +E Sbjct: 316 DAIETTTARGV 326 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 101/413 (24%), Positives = 159/413 (38%), Gaps = 74/413 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V+ A ++V+ A+ I + + G + + G Sbjct: 11 DGYRIAVVPGDGIGPEVSAATVRVLTQAL----GTSFPIEFRDYDAGAECFRRTG--TAF 64 Query: 85 PAETLDLIREYRVAIKGPLTTPV------GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 P T R+ + G P + ++ +R LDLY +RP+R +G P Sbjct: 65 PEATQVACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAP 124 Query: 139 SPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + K P+ I REN+E +YA Sbjct: 125 RRLVGKGPDDIRFTIVRENTEGLYAARGGGN---------------------IIRGQIAT 163 Query: 197 GIKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + EG +R+VR A E A A+ VT+V K N+++ + F++ + Sbjct: 164 DTLVMTREGVERIVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIADGVLA 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + I ++ VI DA ++ RP +DVI C NL GD +S Sbjct: 223 D--------------------CPGIEVEHVIVDAMTVHMIERPEHFDVIVCENLFGDILS 262 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-- 368 D AA +GG+G+AP IG + F+ +HG+AP AG+ NP + ILS MML +G Sbjct: 263 DLGAAIMGGMGLAPSGEIGRDHGYFQGSHGSAPTIAGKGLANPIACILSGAMMLDWLGKR 322 Query: 369 -----WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA+ I + + A D I + Sbjct: 323 HSDPALTRAAERIREATGAVLKAGR-----AVTPDIGGSGSTESCAAEICATL 370 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 155/404 (38%), Gaps = 64/404 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG + + KV+ E G + +GQ + ++ Sbjct: 8 LLPGDGIGPEAMAEVRKVI---AFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDADME 62 Query: 91 LIREYRVAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVRYYQGTP-SPVKH 143 + G + P + + LR+++ LY LRP Y S Sbjct: 63 KALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSSSLK 122 Query: 144 PELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 PE+ D++I RE + +Y G + + + + GI + Sbjct: 123 PEVIEGLDILILRELTGGVYFGEPKE------------------IIDLGNGQKRGIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ A E A R+ VT + K N+MK + Sbjct: 165 YDTYEIERIADVAFELARTR-RNKVTSMEKRNVMK--------------------SGVLW 203 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 + ++ ++ ++ ++ADA Q++ P ++DVI NL GD +SD A G + Sbjct: 204 NQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFDVILTDNLFGDLLSDVAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ G Sbjct: 264 GMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAE 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + G ++ T D +G + +E GDAI+ Sbjct: 324 ADRLEAAIAGVLDDGIRTADI--WSEGNTKVGTTEMGDAILAKF 365 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 298 bits (764), Expect = 2e-79, Method: Composition-based stats. Identities = 98/403 (24%), Positives = 159/403 (39%), Gaps = 78/403 (19%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG +V +++A E + + EI G + +G W Sbjct: 8 DSYQVVLLPGDGIGPEVMAQARDLLEAVAEPS---GVRFELDEIPCGGRFYLEHGARDW- 63 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRPVR 132 P + R V + G + P G S + R +LDLY +RPV+ Sbjct: 64 PEDAEARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVK 123 Query: 133 YYQGTPSPVK-------HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 G + PE DMVI REN+E +YAG+ + + V Sbjct: 124 LLPGVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASV---------- 173 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKFTE 238 + + G +R++R A E R VT + K N+++ Sbjct: 174 ---------ATDTRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GC 223 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 F + ++A E +I + I DAF Q ++ +P YDV Sbjct: 224 KLFAEVFAEVASEY--------------------PDIANELAIVDAFTQWLVTQPEHYDV 263 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIIL 358 NL GD ++D + GG+G+A G N+GDE A+FE HG+AP AG+D+ NP +++L Sbjct: 264 CVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEHAMFEPIHGSAPPLAGKDEANPMAMLL 323 Query: 359 SAEMMLRHMG-------WTEAADLIVKGMEGAINAK-TVTYDF 393 + L +G A + + + +T D Sbjct: 324 ATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVDL 366 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 97/399 (24%), Positives = 162/399 (40%), Gaps = 65/399 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + G GIG + + + I + + Sbjct: 50 KAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYI-------GAPIDFEVVDI-----DPTM 97 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTP 138 + + I+ V +KG + T S NVALR ELD+Y + + Y G Sbjct: 98 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 157 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + D+VI R+N+E YA +E ++ + E + Sbjct: 158 T---RHKDIDVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SM 191 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K + + ++R+ R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 192 KVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY------ 245 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 +I D+I D Q++ +P ++DV+ NL G +S+ + +G Sbjct: 246 --------------PDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLG 291 Query: 319 GIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G G+ G N GD A+FE T T AG++ NP ++I ++ ML H+G A L+ Sbjct: 292 GAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEHLGHQFHASLLR 351 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + IN D D ++ AI++N+ Sbjct: 352 RAINKTIN-----VDRVLTPDLGGSNTSTDVVGAILQNV 385 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 298 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 107/400 (26%), Positives = 167/400 (41%), Gaps = 61/400 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG +V LKV+ A + + E G + G+ L Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPR---HGLTLDTTEYELGAQRWHATGE--VL 58 Query: 85 PAETLDLIREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P + +R++ + G + T P G R L + LR Y+ LRPVR Y G +P+ Sbjct: 59 PDAVEEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPL 118 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 PE DM++ RE +E YAG+ GV + P Sbjct: 119 AGVAPEDIDMLVVREGTEGPYAGMG-------------------GVLRKGTPHEIATQDS 159 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R+VR A A +TLVHK N++ + ++ ++ E Sbjct: 160 VNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEY------- 212 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + + DA + +P +DV+ NL GD I+D AA GG Sbjct: 213 -------------PQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGG 259 Query: 320 IGIAPGANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 IG+A NI GD ++FE HG+AP AGQ K +P + ILS +ML H+G+ +AA I Sbjct: 260 IGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGYADAAAQI 319 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D + + ++ GD I + + Sbjct: 320 DQAVAE---------DLQERAKNGGVRSTTQIGDDIAQRV 350 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 297 bits (760), Expect = 5e-79, Method: Composition-based stats. Identities = 106/389 (27%), Positives = 159/389 (40%), Gaps = 74/389 (19%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +V ++V+ A + + + G Q G + E Sbjct: 4 VAVIPGDGIGPEVIDGAVRVLKAVTGR-------VRFEYYEGGVDVFQECGSPIR--EED 54 Query: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L+ IR + G TTP G RSL + LR+EL LY LR + + + Sbjct: 55 LEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLRII---PDLRTGRE----- 106 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 +VI RENSE +Y GI + + ++ + EG + Sbjct: 107 -IVIVRENSEGLYFGIGAVVN------------------------GRAVDVRLITREGAE 141 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A+E A A +T VHK N++ + F+ ++A EE Sbjct: 142 RIARFAVEQAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE--------------- 184 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + ++D I D+F +++ P E+ VI NL GD +SD G IGI P N Sbjct: 185 ------GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVPSGN 238 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 GD ALFE HG+AP AG+ NP ILS M+L ++G LI + G + Sbjct: 239 YGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLGLD--GSLIRAAVRGYVVNG 296 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D + + II + Sbjct: 297 ELTPDM------GGRARTEDVVRGIIGEI 319 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 296 bits (759), Expect = 8e-79, Method: Composition-based stats. Identities = 85/346 (24%), Positives = 148/346 (42%), Gaps = 55/346 (15%) Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQE 121 + E++ + + + IR RVA+KG + T + +S N LR Sbjct: 1 DFEEVHVSSNADEE------DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTS 54 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDLY + +++ P V + D++I REN+E Y+ +E ++ + E Sbjct: 55 LDLYANV---IHWKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-------- 103 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +K ++ + R+ A + A + R VT VHK NIMK +G F Sbjct: 104 ---------------SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLF 148 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 ++A +I +++I D Q++ RP ++DV+ Sbjct: 149 LQCCREVAARY--------------------PQITFENMIVDNTTMQLVSRPQQFDVMVM 188 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSA 360 NL G+ +++ A VGG G+ GAN G A+FE AT T A ++ NP + +L++ Sbjct: 189 PNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLAS 248 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCS 406 MML H+ A I K + +++ + V + + + CS Sbjct: 249 CMMLDHLKLHSYATSIRKAVLASMDNENVRFPSHPTLLPRPVSPCS 294 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 295 bits (756), Expect = 2e-78, Method: Composition-based stats. Identities = 94/392 (23%), Positives = 158/392 (40%), Gaps = 66/392 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG ++ L+++ EK Y E + G S YG L Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEK-YHFEYHLESHHF--GGVSIDYYGTP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSL----NVALRQELDLYICLRPVRYYQGTP--S 139 ETL + + G + P + + LR+ L+L+ +RP +G S Sbjct: 57 NETLQSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLS 116 Query: 140 PVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G +A +K+ +E Sbjct: 117 PLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQE--------------- 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +R+VR A A R +T V K N++ + ++ + ++ Sbjct: 162 --------IERIVRIAFNLANRR-RKKLTSVDKENVL-SSSKLWRQIVNDVKKDY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ +P ++DVI NL GD +SD + Sbjct: 207 ---------------PEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ G L+E HG+AP A +DK NP ++LS + LR + +AA+ Sbjct: 252 GSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 + + I + T D + SE Sbjct: 312 LESIVYSFIQSNKTTADL------GGQYRTSE 337 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 103/406 (25%), Positives = 161/406 (39%), Gaps = 63/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V + KV+ + E G S +G + E Sbjct: 8 KILLLPGDGIGPEVIQEVKKVI---LWLNSNKSLDFEIDEDLAGGCSYDKHGTP--ITDE 62 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQG-TPSP 140 E + G + P + R +EL L+ LRP ++ + Sbjct: 63 VFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAS 122 Query: 141 VKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 PE+ D++I RE + IY G E G+K I E GI Sbjct: 123 TLKPEIVSGLDIMIVRELTGGIYFG------------------EPRGIKPIENGERKGIN 164 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + R+ + A + A + VT K N+M+ QL +EE Sbjct: 165 THSYTTSEIVRVAKVAFDLARKRS-NRVTSCEKSNVME---------AGQLWKEEVQEL- 213 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + K++ + ++AD Q+L P ++DVI NL GD +SD + Sbjct: 214 ----------HDKEYKDVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQASMLT 263 Query: 318 GGIGIAPGANIGDEC------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 G +G+ P A++G + A++E HG+AP AG++ NP + ILS M LR+ + Sbjct: 264 GSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSLDLD 323 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + K ++ +N T D L G K + S GDAII + Sbjct: 324 SEADALEKAVQDVLNDGLRTKDI--LSQGKKEVSTSAMGDAIISKL 367 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 165/404 (40%), Gaps = 64/404 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG +V + +++D + G G + V + T+ Sbjct: 8 LLPGDGIGTEVMAEVSRLIDWLNK---AGIASFETEHGLVGGAAYDA--DKVAITDATMA 62 Query: 91 LIREYRVAIKGPLTTPVGGGIRS------LNVALRQELDLYICLRPVRYYQGTP-SPVKH 143 L + I G + P + + LR++L L+ LRP Y + Sbjct: 63 LAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEASSLK 122 Query: 144 PELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 PE+ D++I RE + +Y G E + + + I + Sbjct: 123 PEVVEGLDIMIVRELTGGVYFG------------------EPKTITDLGNGQKRAIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 165 YDTYEIERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREY------- 215 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 K++ ++ +AD+ ++ P ++DVI NL GD +SD A G + Sbjct: 216 ------------KDVQLEHQLADSGGMNLVKWPKQFDVIVTDNLFGDMLSDIAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G A++E HG+AP AG+ NP +++ S M LR+ + E Sbjct: 264 GMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGLANPVAMLASFGMALRYSLDMGEL 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + + + T D + +G+ ++ S+ G+AI++ M Sbjct: 324 ADKLDEAIAVVLARGLRTADIKS--EGSTVVSTSQMGEAIVQEM 365 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 290 bits (743), Expect = 5e-77, Method: Composition-based stats. Identities = 102/400 (25%), Positives = 170/400 (42%), Gaps = 62/400 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++ ++V++AA ++ + + G S Q +G V Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKR---FQLDLEIGHDIAGHASLQRHGATV--TPA 56 Query: 88 TLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ ++ + GP+ T G + + R+ELDLY +RP R + G V Sbjct: 57 LLEKVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV-- 114 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 ++ + REN+E YA E G ++ I ++ + Sbjct: 115 -GEFNLAVVRENTEGFYADR----------------NIESGSSEMLITPDTVISLRRITR 157 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+ R+A + A R V++VHK N++K +G F D Q+ARE Sbjct: 158 LCCERIARSAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVARE------------ 204 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ + D I DA + ++ P +DVI N+ GD +SD A G +G+ Sbjct: 205 --------FPQVRVDDFIVDAMMAHVVRAPQRFDVIVTTNMFGDILSDLTAELSGSLGLG 256 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLI 376 N G + A+ +A HG+AP AG++ NP S+ILSA +L G + AA I Sbjct: 257 GSLNAGKDHAMGQAVHGSAPDIAGRNIANPYSLILSAGQLLGWHGQRKNLPAFALAARAI 316 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ A+ T D L +E G + + + Sbjct: 317 DETATAALQAREGTRD------AGGELGTAEAGQSFVRRL 350 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 290 bits (743), Expect = 6e-77, Method: Composition-based stats. Identities = 102/387 (26%), Positives = 156/387 (40%), Gaps = 64/387 (16%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL 89 I GDGIG +V LKV+ A + G Q G+ LP L Sbjct: 4 AVIPGDGIGPEVVAEGLKVLRAVAP-------DVESTPYDLGASRWQRTGE--LLPDTVL 54 Query: 90 DLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 D +R + + G + P G R L + LR ELD ++ LRP R + G SP+ P Sbjct: 55 DELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAPGA 114 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 DM+ RE +E Y G GV + P + + G Sbjct: 115 IDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAFGV 155 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+VR A E A+A R +TL+HK N++ + +++ E Sbjct: 156 ERVVRYAFERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAE--------------- 200 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 E+ + DA + P +DVI NL GD ++D AA GGIG+A Sbjct: 201 -----FPEVTVAYQHVDAASMFFVTDPGRFDVIVTDNLFGDIVTDLAAAVTGGIGLAASG 255 Query: 327 NI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N+ G ++FE HG+AP AG+ +P + +LS ++L H+G + A + + Sbjct: 256 NLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSVGLLLDHLGRADQARKVNAAVA-- 313 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGD 410 +D D ++ + GD Sbjct: 314 -------FDL-STRDPEAQVRTEDVGD 332 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 288 bits (738), Expect = 2e-76, Method: Composition-based stats. Identities = 87/404 (21%), Positives = 155/404 (38%), Gaps = 64/404 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG + + K++ E G E G + +G + + Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAG---FVTDEGLVGGCAYDAHG--AAISEADMQ 62 Query: 91 LIREYRVAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + G + P + + LR++L L+ LRP Y S Sbjct: 63 KALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLK 122 Query: 145 ----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D++I RE + +Y G + + + + GI + Sbjct: 123 PELVEGLDILIIRELTGGVYFGEPKE------------------IIDLGNGQKRGIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ A E A + V + K N+MK + + + + ++ Sbjct: 165 YDTYEIERIAGVAFEMARTRQ-NRVCSMEKRNVMK-SGVLWNQVVTETHKAKYS------ 216 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ ++ ++ADA Q++ +P ++DVI NL GD +SD A G + Sbjct: 217 -------------DVQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ + Sbjct: 264 GMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNMVKE 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + K + ++ T D + DG + + E G+AI+ Sbjct: 324 ADDLEKAIANVLDKGIRTGDI--MADGCRQVGTVEMGEAILAEF 365 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 288 bits (737), Expect = 3e-76, Method: Composition-based stats. Identities = 102/388 (26%), Positives = 155/388 (39%), Gaps = 60/388 (15%) Query: 39 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 97 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 98 AIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVIF 152 + G L P + R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 212 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 213 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTG 272 A +YA AN R VT+ K N M+ + +++ + Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEVRAQY-------------------- 214 Query: 273 KEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-- 330 EI V DA ++ P ++ VI NL GD ++D AA GG+G+A AN+ Sbjct: 215 PEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGAALQGGLGMAASANVHASD 274 Query: 331 --ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 ALFE HG+AP AG+D NP + +L+A ++L H+GW E I + + A++ Sbjct: 275 PARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLGWPEEERRIERWVSQALDQGM 334 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D L G + E + Sbjct: 335 CTVDV------GGTLGTRAAGAWVREQI 356 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 288 bits (737), Expect = 3e-76, Method: Composition-based stats. Identities = 111/396 (28%), Positives = 169/396 (42%), Gaps = 65/396 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 ++ I IEGDGIG +V PA + V+ A E S+ E G+ + G Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE------VGFSFTEKQAGDDTRDQTG- 53 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP T + + + G G + + LR+ + ++ +RP R Y G + Sbjct: 54 -AALPETTYEAAADADATLFGA----AGETAADVILPLREAVGSFVNIRPARAYPGVDAL 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 TD+V REN+E +Y+G E R E + Sbjct: 109 ---QPETDLVFLRENTEGVYSGHE-----------------------DRLSEDLSTLTRV 142 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +++L A Y D VHK N+M+ T+G F+D ++A Sbjct: 143 ITTSASEQLAEYACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVA----------- 191 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ +V+ DAF ++ L P ++DV+ C NL GD +SD A VGG+ Sbjct: 192 ----------ASNDVATNEVLMDAFATRVCLNPTQFDVVVCPNLAGDVLSDLAAGLVGGL 241 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ P ANIG ALFE HGTAP AG NP + ILSA M+L ++G T+AA + + Sbjct: 242 GLLPSANIGQTNALFEPVHGTAPDIAGDGIANPSASILSAGMLLEYLGETDAATNVQMAV 301 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E +N+ T D +A+IE + Sbjct: 302 ESVLNSGPRTPDL------GGNASTEAVVNAVIEQL 331 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 288 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 92/415 (22%), Positives = 161/415 (38%), Gaps = 68/415 (16%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + K K + + + I G+G+G ++ A+ +V+ A + Sbjct: 62 QDKQKSKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAV-------KA 114 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W +++ K+ + E L +R +V IKGP+ + R +R++ Sbjct: 115 PIEW-DVHDEFKAKDSDD----VSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQ 163 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 + + + +G SP D+VI R+ E Y+GIE + Sbjct: 164 FAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVVPGVMQ-------- 212 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 IK + G R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 213 ---------------TIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 257 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 + A + +++ ++ D + +ILL+P + DV+ Sbjct: 258 LEAMRAEADKHVD-------------------DVLFEERYLDTCILKILLKPHKCDVMVS 298 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 ++ GD + +G GI PG ++ +F+ AG+D NP +LSA Sbjct: 299 SSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAA 358 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MLRH+ + AD ++ AI D R D KCSEF A+ + + Sbjct: 359 LMLRHVKMDKQADQ----VDCAIRKVYKDTDI-RTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 288 bits (736), Expect = 4e-76, Method: Composition-based stats. Identities = 112/397 (28%), Positives = 158/397 (39%), Gaps = 66/397 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V L V+DA + + G+ L Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGS 72 Query: 88 TLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD IR A+ G + P G +R + LR ELDLY+ RP R + SP++ P Sbjct: 73 DLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDP 132 Query: 145 --ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D VI REN+E +Y+GI A + PE + + + Sbjct: 133 ARRAIDCVIVRENTEGLYSGIGGGARTGT-------------------PEEIAVDVDLST 173 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD-WGYQLAREEFGGELIDGG 261 G R++ A A R SV LV K N ++ ++ WG +AR Sbjct: 174 RHGVSRVLEFAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVARH---------- 219 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + D ++ P +DVI N GD +SD AA GG+G Sbjct: 220 -----------PHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDILSDLTAALAGGLG 268 Query: 322 IAPGANIGDEC--ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 +A AN+ ALFE HG+AP AG NP ILS ++ H+G E AD + + Sbjct: 269 VAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAEHLGRNEEADAVRRA 328 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ A VT D L E G A++ + Sbjct: 329 VAAAVAAGRVTPDL------GGPLGTKEVGAAVLAEL 359 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 286 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 89/410 (21%), Positives = 148/410 (36%), Gaps = 73/410 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG ++ + L V++ E+ G + + G Q G Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG--TAFS 61 Query: 86 AETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 E + ++ + G + P G + + LR E+DLY LRP+R Y P + Sbjct: 62 DENMAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVL 121 Query: 142 --KHPELTDMVIFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 K D+V+ RE +E I Y+ + + Sbjct: 122 VDKRASQIDLVLVREQTEGILYS----------------------RCRGTIEDDRVAWET 159 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD-----SVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S GT R+ A A + V V + N + + F+ ++A Sbjct: 160 MMISRNGTSRVSEFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEVAERH- 217 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 + D +++ P E+DV+ N G +SD Sbjct: 218 -------------------PSVSADYAYVDTTAMKLVKSPWEFDVLVTENAFGGILSDLA 258 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM----GW 369 A VG +G+AP A+IG++ A+F+ HG+AP AGQ NP + ILS +ML + G Sbjct: 259 AGVVGSLGLAPSADIGEKHAVFQPAHGSAPHIAGQGLANPVAQILSVALMLDWLADQHGE 318 Query: 370 TE---AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ +E A+ ++ + AII + Sbjct: 319 PRLAHGARILEHAVEKALT-------VVCPVEFGGKDGTAAITKAIIAQI 361 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 285 bits (730), Expect = 2e-75, Method: Composition-based stats. Identities = 100/412 (24%), Positives = 163/412 (39%), Gaps = 65/412 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I ++ GDGIG +V + +V+D + G + G + G + Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQ---TGRTAFEVEDALVGGAAYDAQGTPL 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSL-------NVALRQELDLYICLRPVRYYQ 135 +T+ L + G + P + LR++L+L+ LRP + Sbjct: 58 H--DDTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFD 115 Query: 136 GTPSPVKHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 D++I RE + +Y G + G+ + Sbjct: 116 ALAEASTLKTELVSGLDVMIVRELTGGVYFG------------------QPRGISALPNG 157 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E G+ + R+ + A + A + V K N+M+ G L RE Sbjct: 158 ERRGVNTQVYDTHEIVRVAKVAFDLAGKRG-KRLCSVEKANVME--SGL-------LWRE 207 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 E D EI + + AD Q++ +P ++DVI NL GD +SD Sbjct: 208 EVTKLGAD------------YPEIALSHMYADNCAMQLVRQPKQFDVIVTDNLFGDILSD 255 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 A G +G+ P A++ G+ A++E HG+AP AGQDK NP + ILS MMLR Sbjct: 256 CAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDKANPLATILSFSMMLR 315 Query: 366 H-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E ADL+ + G + T D + G L+ + GDA++ M Sbjct: 316 YSFDLAEEADLVDNAVRGVLAKGLRTGDIFQP--GKTLVGTTGMGDALLAEM 365 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 285 bits (728), Expect = 3e-75, Method: Composition-based stats. Identities = 113/404 (27%), Positives = 199/404 (49%), Gaps = 39/404 (9%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + + VP+ I YI+GDGIG ++T AM+ VV++A+E AY+G R I W +I G Sbjct: 10 YIEFTDSGMVVPDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGT 69 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + +G ++P +++ I++ +A+K L R LN LR+ L LY +R ++ Sbjct: 70 EAYEKFG--TYVPEDSIKEIQKMYIAMKSTL--NFMPDKRDLNTILRKRLGLYSNIRILK 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 Y +G PV ++ I R+++ + + + S + +I+F+ + G + Sbjct: 126 YIEGMDIPVNTFNRLNLTIIRDSTPNSHI---FYHSSESTDDLIRFISDNYG---LNITP 179 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 GI + P S+ T+++ + A+ Y+ N + +T++ F +W + A Sbjct: 180 DSGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEA--- 231 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + +++ + + F+++++ P +++VI N+ + D Sbjct: 232 -----------------SAQEDVGYEVLKTREFMKRLISSPEDFEVILVDNVLSQTLVDY 274 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 LA G I I G++IGDECA+FEA + P AG D +P S ILS ML H+GW EA Sbjct: 275 LA---GTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEA 331 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + A + D D + +KCSEF II+ M Sbjct: 332 AQIIENAISAAFRDNKIPKDINTRPDIS-PIKCSEFSSEIIKRM 374 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 284 bits (727), Expect = 3e-75, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 161/382 (42%), Gaps = 62/382 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + + GDGIG +V A + A A + + + E G + + G V Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTP--VGGGIRSL--NVALRQELDLYICLRPVRYYQGTP 138 ETL E + G + P GG +R +ALR+EL + LRPV Sbjct: 58 --SKETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALS 115 Query: 139 --SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D++I RE + Y G + E Sbjct: 116 GSSPLRPGVAEGVDLLIVRELTGGAYFG------------------------EKEEGEER 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + + +R+ R A E A R V V K N++ T ++ ++AR+ Sbjct: 152 ASDLSVYTRGEVERVARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDY-- 207 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ ++ V+ DA ++ P +DVI NL GD +SD A Sbjct: 208 ------------------PDVALEHVLVDAAAMHLVTDPGRFDVILTENLFGDILSDEAA 249 Query: 315 AQVGGIGIAPGANIGDECA--LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 G +G+ P A++G+ + +FE HG+AP AG+ NP + ILSA MM RH +G E Sbjct: 250 VLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPYAAILSAAMMFRHGLGRPE 309 Query: 372 AADLIVKGMEGAINAKTVTYDF 393 AA+ I +G+E A+ A +T D Sbjct: 310 AAEAIERGVEAAVAAGCLTPDL 331 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 284 bits (727), Expect = 4e-75, Method: Composition-based stats. Identities = 102/276 (36%), Positives = 145/276 (52%), Gaps = 34/276 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDG G ++ A +V++A W G + G LP Sbjct: 5 VTLIRGDGTGPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPDSV 55 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E D Sbjct: 56 LESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF---ENID 112 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +V+ REN+ED+YAGIE++ + + ++ +L ++ I+ P GI IKP S G++R Sbjct: 113 LVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPG--GISIKPMSVPGSER 170 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 +VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 171 IVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEY---------------- 214 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 +I D I D Q++ +P YDV+ NL Sbjct: 215 ----PDIEFDDRIVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 284 bits (726), Expect = 5e-75, Method: Composition-based stats. Identities = 85/401 (21%), Positives = 160/401 (39%), Gaps = 59/401 (14%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIGV+V + +++D K + + E G + V+G Sbjct: 8 ILPGDGIGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPYPAETLEAA 64 Query: 91 LIREYRVA--IKGPLTT--PVGGGIRSLNVALRQELDLYICLRPVRYYQGT-PSPVKHPE 145 L + + + GP P + +R+++ L+ LRP + + E Sbjct: 65 LAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADASTLKAE 124 Query: 146 LT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D++I RE + +Y G + G+ + G + Sbjct: 125 VVSGLDIMILRELTGGLYFG------------------QPRGIDTLPDGTRKGYNTLVYT 166 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +R+ R A + A + + V K N+++ T +++ +L +EEF Sbjct: 167 TPEIQRIGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEF--------- 215 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + + D Q++ P ++DV+ N+ GD +SD A G +G+ Sbjct: 216 ----------PDVELTHMYVDNAAMQLVRNPKQFDVMVTENMFGDILSDCAAMLTGSLGM 265 Query: 323 APGANIGD------ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 P A++G+ AL+E HG+AP AG+D NP + I+S M LR+ ADL Sbjct: 266 LPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANPLATIMSFAMCLRYSFDMAAEADL 325 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I ++ + T D + G + + G+A++ + Sbjct: 326 IETAVKNVLKGGLRTADIMQP--GKAKVSTTVMGEAVVREL 364 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 102/457 (22%), Positives = 171/457 (37%), Gaps = 96/457 (21%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + +Q K L + + GDGIGV++ + ++ A +S Sbjct: 16 IQAASQPSKAFFSQSALQREAIKKVTLLPGDGIGVEICSCVCELFHYANIPIQWDTYLVS 75 Query: 65 WMEIYTG------------EKSTQVYGQD--------VWLPAETL-------------DL 91 G E+ + G+ +L E Sbjct: 76 GSFFGVGSDSSLNPTRNLIEEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQS 135 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMV 150 I +V +KGP T +S++ L + LY + PV+ Q P V P DMV Sbjct: 136 ILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMV 193 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 + REN+E Y+G+E + E +K + +G+ R+ Sbjct: 194 VVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRDGSMRIA 230 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 231 KWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEY------------------ 272 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I ++I D + Q++ P +D V+ NL G +S+ ++ VGG+G+ G N Sbjct: 273 --PDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNA 330 Query: 329 G-----DECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 D +FE A +G+ NP +I S+ ML HMG A+ I ++ Sbjct: 331 TDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMGMNTHANRIKFALKE 390 Query: 383 AI---NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + N K +T D F +A++ ++ Sbjct: 391 TLLNANPKILTPDI------GGTGSSVSFIEAMMRHI 421 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 282 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 102/404 (25%), Positives = 167/404 (41%), Gaps = 71/404 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG + L+V ++ K+ + I G + ++ L Sbjct: 45 DHITVGILPGDGIGPCIMEQALRVAKYLLKDEMASG-KVEFRTIP-GMTIEERVQKNESL 102 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSP 140 PAE L+ + V +KGP TP G S N LR+ L LY +RPVR + Sbjct: 103 PAEVLEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE----- 157 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D FREN E Y G K I+ + + K Sbjct: 158 ----KGIDWTFFRENIEGEYI---------------------WGNKGIQVDDDLAVDFKV 192 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R+ RAA E+A N + +VT+V K NI+K +G F + L +E Sbjct: 193 LTRPGAERICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEY-------- 244 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLR--PAEYDVIACMNLNGDYISDALAAQVG 318 I +++ + D+ +I + V NL GD ++D A G Sbjct: 245 ------------PGITVREELVDSMAAKITDQEFTKGMQVFLLPNLYGDIVTDVAAEYQG 292 Query: 319 GIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADL 375 G+G A +NIGD+ ALFEA HG ++ +P S+I + M+ H+G+ E + Sbjct: 293 GLGTASSSNIGDQYALFEAIHGVGNFLVQHNRAQYADPCSLIRAMGEMISHIGYPEKKEQ 352 Query: 376 IVKGMEGAINAK---TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +VK ++ + +T D + EF D +++ + Sbjct: 353 LVKALDICTRTERKVVITTDKD-------GATAEEFTDYLLDTL 389 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 279 bits (713), Expect = 2e-73, Method: Composition-based stats. Identities = 89/416 (21%), Positives = 159/416 (38%), Gaps = 73/416 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GD IG ++ +KV+ + ++ + G S +G V + Sbjct: 4 TYKILVLPGDHIGPEIMAEAIKVLTTI--ETHRPNLHFNLTTDLVGGTSIDTHG--VPIT 59 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGT---P 138 LD + + G + P G+ S + LRQ LD + LRP + + Sbjct: 60 QSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGA 119 Query: 139 SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP++ + T ++ REN Y G + + E Sbjct: 120 SPIREHVVKGTRFIVVRENCGGAYFGEKKEE------------------------EDVAS 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLA 249 + + +RL R + A R +V K N++ + ++ + Sbjct: 156 DLWVYTRPEIERLARVSAAVARIMGRSEDDNQAATVWSADKANVL-ASGRLWRRITSDIF 214 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDY 308 +EF +I ++ +AD+ ++ P ++ VI N GD Sbjct: 215 AKEF-------------------PDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTFGDI 255 Query: 309 ISDALAAQVGGIGIAPGANI----GDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAE 361 +SD A G +G+ P A++ G+ ++E HG+AP +G+ NP + ILS Sbjct: 256 LSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQILSVA 315 Query: 362 MMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MMLR+ MG + A + + + ++AK+ R D CS+ GDA+ E + Sbjct: 316 MMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCEVL 371 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 279 bits (713), Expect = 2e-73, Method: Composition-based stats. Identities = 93/391 (23%), Positives = 156/391 (39%), Gaps = 65/391 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + G GIG ++ L+V+ AA +S+ K E Sbjct: 40 VTILTGSGIGPEIMDHTLRVLKAA-------GAPLSYEIFALSSKDGSKNNDF----DEA 88 Query: 89 LDLIREYRVAIKGPLT-TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L IR RVA+KG + I+S N+ R+ LDL++ + + + G Sbjct: 89 LTSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLS---NKFGEI 145 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+ + R+N+E Y +E + + E +K + + Sbjct: 146 DITVIRQNTEGEYLMLEHEPRTGSVE-----------------------SLKVLTRFNLE 182 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 RL+ A +YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 183 RLIEFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSY--------------- 227 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I + + + + +I P +DVI NLNG IS+ L +GG G+ G N Sbjct: 228 -----PMIKMNVLDVNVAIFKIASNPRIFDVILATNLNGSMISNYLNGMLGGPGLTSGIN 282 Query: 328 IG-DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 D A+FE G ++ NP ++I+S +L H+G+ + A++I + + Sbjct: 283 FSADGIAVFEPGARNKGSSIVGLNRANPIAMIMSGINLLHHLGYNKTAEMIHNSVYATL- 341 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 YD R D E D II ++ Sbjct: 342 ----VYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 273 bits (699), Expect = 7e-72, Method: Composition-based stats. Identities = 157/219 (71%), Positives = 183/219 (83%), Gaps = 1/219 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + LNVP NPIIP+IEGDGIG+D++P M+KVVDAAV+KAY GE Sbjct: 3 YQKIQVPATGDKITVNADTSLNVPNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISWME+Y GEK+TQVY QD WLP ETLD +++Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+CLRPVR+++G PSPVK P DM IFRENSEDIYAGIEWKA S +A KVIKFL+ Sbjct: 123 QLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLK 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 219 EEMGV KIRF + CGIG+KP S+EGTKRL R A+ A A Sbjct: 183 EEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 272 bits (696), Expect = 2e-71, Method: Composition-based stats. Identities = 102/421 (24%), Positives = 165/421 (39%), Gaps = 78/421 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG ++T A ++ E +I W + + +G V P ET Sbjct: 17 ITLLPGDGIGPEITDACRGLIADVFPHWELTETQIGWSQ-------WRAHGNPV--PQET 67 Query: 89 LDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRY 133 + + A+ +T+ G RS + LRQ LDL+ +RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAG------IEWKADSADAEKVIKFLREEMGVKK 187 G + D I REN+E +Y+ + ADS + + + + Sbjct: 127 LPGAAA--------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARA 178 Query: 188 IRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND--------RDSVTLVHKGNIMKFTEG 239 + + ++ + RL R A + A+A +VT+ K NI++ + Sbjct: 179 VDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSAR 238 Query: 240 AFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 + ++A E ++ ADA Q++ PA +DVI Sbjct: 239 VIRGAVEEVAEEY--------------------PQVAFDFANADAVAMQLVTDPARFDVI 278 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILS 359 NL GD +SD A +GG+G+A AN+GD A+FE HG+AP AG+ NP + +LS Sbjct: 279 IAENLIGDILSDIGAGLIGGLGLAASANVGDNFAVFEPVHGSAPDIAGRGIANPAAFLLS 338 Query: 360 AEMMLRHMGWT----EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 A M H+G A + + + A +D SEF A+ Sbjct: 339 AAMCAEHLGAPVSELAPAAKLREAVYAATRT-------APTLDLGGTATTSEFVAAVRAE 391 Query: 416 M 416 + Sbjct: 392 L 392 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 270 bits (690), Expect = 7e-71, Method: Composition-based stats. Identities = 105/399 (26%), Positives = 170/399 (42%), Gaps = 70/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +++G G+G D ++ ++ AA + + + G + + +G+D LP Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAA-------KVPVEFEVHLAGRMALE-HGKD-ALPKA 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR----------SLNVALRQELDLYICLRPVRYYQGT 137 T D IRE +A+K L P G G+ + NVA R++L L+ +RPV G Sbjct: 54 TFDAIRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGI 113 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 PS D ++FRE +ED+Y E + + Sbjct: 114 PSRFT---GVDFLLFREITEDLYTASEHEIVPGVVQ-----------------------S 147 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 K +E R + A + A R +V +HK NI+K +G F + Y++A+E Sbjct: 148 FKIVTEAACLRFFKLAFDTARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEY----- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 EI KD+I D Q++ RP +++V+A NL GD +SD A V Sbjct: 203 ---------------PEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGAGLV 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+ N G+ ++EA +G + + D NP +IL A +L+ +G T A I Sbjct: 248 GGVSTTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETGTAGRIQ 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E + + R D + F DAI+ M Sbjct: 308 KAVETVLLEGRI-----RTRDIGGTATTTAFTDAIVSRM 341 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 269 bits (689), Expect = 1e-70, Method: Composition-based stats. Identities = 98/387 (25%), Positives = 154/387 (39%), Gaps = 48/387 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ P + +V + IS S + + + + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTFYNIS---------SERYINKGITIKDSE 54 Query: 89 LDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 +D ++ Y G + G + + + LR+ELDLY+ +RP + Sbjct: 55 IDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----N 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 M I REN ED Y+ I + + + + S + Sbjct: 110 NIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKN 169 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 KR A + A D ++VT+ K N + Y L RE E G + Sbjct: 170 LKRFFNMAYKIA---DTETVTITDKANAVDM---------YSLWREIAIEESEPAGKKIN 217 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + AD+ ++ P +Y I NL GD +SD +A VGG+G AP Sbjct: 218 FEY-------------ADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPS 264 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 NIGD ++FE HG+AP AG++ NP + ILS MML+H+ TE A ++ K +E I Sbjct: 265 GNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVENVIR 324 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAI 412 T+ ++ EF + + Sbjct: 325 NGTI------PIESGGNAGTHEFINKV 345 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 165/402 (41%), Gaps = 73/402 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + A L V ++K ++++ ++ I G + Q+ LP Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKE-IADQRVEFVPIK-GMTIEERARQNKSLPPA 96 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ + + +KGP TP G S N LR++L LY +RP+R + Sbjct: 97 VLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE-------- 148 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 + D FREN E Y G K I + I K S+ Sbjct: 149 -KGIDWTFFRENIEGEYI---------------------WGNKGICVGDDLAIDFKILSK 186 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +RL R A EYA ++ + ++T+ K NI+K +G F + + +E Sbjct: 187 PGAERLFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEY----------- 235 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPA---EYDVIACMNLNGDYISDALAAQVGGI 320 I +++ + D+ ++ + P V NL GD ++D A GG+ Sbjct: 236 ---------PGIHVREELIDSLSAKL-MDPEFNAGMQVFVLPNLYGDILTDIAAEYQGGL 285 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLIV 377 G A +NIGD+ A+FEA HG ++ +P S+I + M+ +G+ E D + Sbjct: 286 GTASSSNIGDQYAMFEAIHGVGVYLVEHNRAQYADPSSLIRAMGEMMAFIGYPEKRDRLF 345 Query: 378 KGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ +T D + EF + ++E + Sbjct: 346 KALDFCTKVERKAVITTDKD-------GATAEEFAEYVVETL 380 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 268 bits (685), Expect = 3e-70, Method: Composition-based stats. Identities = 100/407 (24%), Positives = 161/407 (39%), Gaps = 67/407 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDGIGVDV A + V++ A++ + GE + EI G + G D+ E Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLDIEDGGE 59 Query: 88 TLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + G + P G S ++ LR LY +RPV+ Y P + Sbjct: 60 --ERAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLAD 117 Query: 144 PE--LTDMVIFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+VI RE++E + Y+ K + + + Sbjct: 118 PRAAGIDLVILRESTEGLFYSAAAHKR-------------------SLVVNDDEVQDVLR 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + + T +L R A A +T V K N+ FT AF + + EF Sbjct: 159 ITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANV--FTSLAFFRQIFDEVKSEFA-- 214 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + DA ++ +P E+DV+ N+ GD +SD Sbjct: 215 -----------------DVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGDILSDLAGGL 257 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT------ 370 VGG+G+A IGD LF+ HG+AP G+DK NP + ILSA +ML ++ Sbjct: 258 VGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYLAEKLDKPSL 317 Query: 371 -EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA+LI +E + R ++ + ++ + Sbjct: 318 ADAAELIDSAVETGFWHNAL-----RPIEFGGDMGTRAVTKELLGRV 359 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 267 bits (683), Expect = 5e-70, Method: Composition-based stats. Identities = 102/345 (29%), Positives = 159/345 (46%), Gaps = 38/345 (11%) Query: 47 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 106 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGEDQQ-----GLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 107 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSG---KRIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 VH+ + M T+G F + +A+E +I D + Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQE--------------------FPDIAFADRSIEVIC 222 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 Q+++ +P +DV+ NL GD ++ A VGG+ + P A++GD+ A+F T Sbjct: 223 QELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVF-GAQSTGTDDV 280 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTY 391 G D P S+IL+ +MLRH+G EAA + +E + + T Sbjct: 281 GHD---PTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVDTT 322 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 266 bits (681), Expect = 9e-70, Method: Composition-based stats. Identities = 87/407 (21%), Positives = 157/407 (38%), Gaps = 71/407 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GD +G ++T +KV+ A + + K + G + G V LP E Sbjct: 6 KIVVLPGDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--VPLPDE 61 Query: 88 TLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTP---SP 140 L+ ++ + G + P G + +R+EL LY LRP + + SP Sbjct: 62 ALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSP 121 Query: 141 VK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +K + TD V+ RE IY G + D + Sbjct: 122 IKPQFAKGTDFVVVRELVGGIYFGKRKEDD----------------------GDGVAWDS 159 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +R+ R A A+ ++ + + K N++ + ++ + + EF Sbjct: 160 EQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVL-ASSRLWRKTVEETIKNEF---- 214 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 + ++ + D+ ++ P + +I N+ GD ISD + Sbjct: 215 ---------------PTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVI 259 Query: 317 VGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGW 369 G +G+ P A++ L+E HG+AP ++KVNP + ILSA MML+ + Sbjct: 260 PGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-PKNKVNPIATILSAAMMLKLSLNL 318 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E I ++ ++A T D +E GDA+ E + Sbjct: 319 PEEGKAIEDAVKKVLDAGIRTGDL------GGSNSTTEVGDAVAEEV 359 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 86/368 (23%), Positives = 145/368 (39%), Gaps = 61/368 (16%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +DA E + I W +++ K+ + E L +R +V IKGP+ + Sbjct: 1 MDAVQEVICAVKAPIEW-DVHDEFKAKDSDD----VSPEVLKSLRANKVGIKGPVDS--- 52 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 53 ---RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVV 106 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + G R+ YA+ N R +T+ Sbjct: 107 PGVMQ-----------------------TIKVSTTAGAARIAEFVFNYAVKNKRKRITVA 143 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +++ ++ D + + Sbjct: 144 HKANIMRMTDGNFLEAMRAEADKHVD-------------------DVLFEERYLDTCILK 184 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 ILL+P + DV+ ++ GD + +G GI PG ++ +F+ AG+ Sbjct: 185 ILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGK 244 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408 D NP +LSA +MLRH+ + AD ++ AI D R D KCSEF Sbjct: 245 DLANPTGPLLSAALMLRHVKMDKQADQ----VDCAIRKVYKDTDI-RTPDVGGKAKCSEF 299 Query: 409 GDAIIENM 416 A+ + + Sbjct: 300 VKAVCDCL 307 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 264 bits (676), Expect = 3e-69, Method: Composition-based stats. Identities = 102/410 (24%), Positives = 157/410 (38%), Gaps = 86/410 (20%) Query: 42 TPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAI 99 LKV+ A E I W ++ G + G W P++ + + Sbjct: 1 MREGLKVLHAVSEPLG-----IEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLIL 54 Query: 100 KGPLTTPVGGGIR-------------SLNVALRQELDLYICLRPVRYYQGTPSPVKH--- 143 G + P G S + R L+LY +RP++ Y G + Sbjct: 55 LGAVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHK 114 Query: 144 ----PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 DMVI REN+E +YA K V I + Sbjct: 115 QIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKADV-------------------AIDTR 155 Query: 200 PCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 156 VITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEY 214 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 EI I DAF Q ++ +P YDV N+ GD ++D Sbjct: 215 --------------------PEIEKDTAIVDAFTQWLVGQPEYYDVCVTSNMFGDIVTDL 254 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + GG+G+A G NIG A+FE HG+APK+AG+DKVNP ++ILS + L + + Sbjct: 255 ASTLQGGMGMAVGGNIGKHNAMFEPIHGSAPKHAGKDKVNPIAMILSVKEGLEWLAARKD 314 Query: 373 ADLIVKGMEGAI--------NAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 + K E +T+TYD + + KCSE G AI E Sbjct: 315 DATLTKAAEAIEAAVVEVLEKGETLTYDL---VGNDRASKCSEVGSAIAE 361 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 264 bits (674), Expect = 6e-69, Method: Composition-based stats. Identities = 86/403 (21%), Positives = 163/403 (40%), Gaps = 61/403 (15%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V +KV+ ++ + ++ G + G P ET Sbjct: 6 IALLAGDGIGPEVMKEAVKVLKLIEQR--NEDVNFELNDVLFGAAAYFAMGH--AFPDET 61 Query: 89 LDLIREYRVAIKGPLTTPVGGG---------IRSLNVALRQELDLYICLRPVRYYQGTP- 138 + +KG + R + LR+ + + RPV +G Sbjct: 62 KAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAH 121 Query: 139 -SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP+K E D++I RE +Y G + +AD ++ ++ + E Sbjct: 122 FSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLE------------- 168 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 E+ +++V+ E ++ + + +HK N++K + + + + ++ Sbjct: 169 ------YDEDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKNY-- 218 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 E+ +K+++ DA + L P +DV+ N+ GD +SD Sbjct: 219 ------------------PEVEVKNILVDAAATYLCLNPGMFDVMVMENMFGDILSDQGG 260 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGWTEAA 373 +G +G+ P A G + + +E +HG+AP AG+ NP S+I S +ML G + A Sbjct: 261 GILGSLGLMPSACKGPDKSYYEPSHGSAPDIAGKGIANPYSMIGSVALMLEMSFGLEKEA 320 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + M+ T D + + A L+ +EFGD + + Sbjct: 321 KNLWAAMQAVFENGYSTSDLSKEGE-ANLVSTAEFGDLVCAEL 362 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 261 bits (668), Expect = 3e-68, Method: Composition-based stats. Identities = 88/417 (21%), Positives = 149/417 (35%), Gaps = 69/417 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGIG +V +V++ + E K+ + G S +G+ L Sbjct: 4 RTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDF--GGCSIDKHGEP--L 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQGTP- 138 A TL+ + + G + P G +ALR+ L LY +RP + + Sbjct: 60 TAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLL 119 Query: 139 --SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP+K D+++ RE Y G + R E Sbjct: 120 AYSPLKPSVARGVDIIVIRELIGGAYFGERKELG-------------------ARAQEDA 160 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 S +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 161 AWDTMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL-ASSRLWRKVATETIQNEF- 218 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ + + D+ I+ P + + VI NL GD +SD Sbjct: 219 ------------------PQLKLDHHLVDSASMLIVANPKKLNGVILTENLFGDILSDES 260 Query: 314 AAQVGGIGIAPGANIGDEC-------------ALFEATHGTAPKYAGQDKVNPGSIILSA 360 + G +G+ P A++ ++E HG+AP AGQ NP ILSA Sbjct: 261 SVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIANPIGTILSA 320 Query: 361 EMMLRHMG-WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 M+ W A I +EGA + R D K + G ++E + Sbjct: 321 AMLCGTRSVWRSPAKAIEAAVEGARRQGDR-REGLRTADLGGSSKTKDIGHKVVEIL 376 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 77/388 (19%), Positives = 152/388 (39%), Gaps = 58/388 (14%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG ++ ++K+V + + Y KI+ + Y G S + + + Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCIYTGY----KINIIYNYIGGISIDKFNTP--ITNNLIS 59 Query: 91 LIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 +I+ G + + LR++ + + +RP++ P K+ Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFKN--- 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I RE + IY G ++ P K +E+ Sbjct: 111 IDIIIVRELNGGIYYGKPKGFSKQIINQI---------------PTWYAYNTKIYNEQEI 155 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 RL R + A+ N + + + K N+++ FK W + Sbjct: 156 IRLARISFNLAL-NRKKKLCSIDKSNVLET----FKLWKKTINYVH-------------- 196 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ + + D ++ ++DVI NL GD ISD + G +G+ P Sbjct: 197 ---KFYNKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGMLPSI 253 Query: 327 NIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAI 384 +I ++ +LFE HG+AP A ++ NP +LS MM + + + ++ + + + Sbjct: 254 SINNKSLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYVLNDFKLSNNLYYSIYKVL 313 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAI 412 + T D ++ + K++ EFGD + Sbjct: 314 SYGFCTIDMKKYIRNFKIVSTEEFGDLV 341 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 257 bits (657), Expect = 5e-67, Method: Composition-based stats. Identities = 90/397 (22%), Positives = 155/397 (39%), Gaps = 63/397 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVE-KAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I G+GIG +V A LK++ + + + + W+ G + + G + Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVDYGWL----GATAFEQLGS--YF 61 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP-SPVKH 143 P T +L + G ++ + + LR+ D + LRP+R Sbjct: 62 PQATTELCDGADGIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 144 PELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 PE D++I RE IY G ++ R G +R+ + Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDE---------RGNYGYHTMRYYDE------- 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ R A+E A R +T+ HK N + W + E Sbjct: 159 ----EIRRIARKALEQA-QYRRGLLTVAHKENALPH-----LHWTRLVQEE--------- 199 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++++ ++ D Q++L P +DVI NL GD +SD A VG I Sbjct: 200 --------ATKFPNVIVEPMLVDNLAMQMVLNPQRFDVILASNLFGDILSDIGGALVGSI 251 Query: 321 GIAPGANIG-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ A++ + L+EA HGTAP AG NP + + +ML+ G +AA I+ Sbjct: 252 GLLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLGACVLMLQQWGEVQAAQQIIAA 311 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + L+ + D ++E + Sbjct: 312 QDRILAKGYRTADLFTQGEEI-LVNTATLVDLLLEEL 347 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 256 bits (655), Expect = 9e-67, Method: Composition-based stats. Identities = 101/407 (24%), Positives = 161/407 (39%), Gaps = 109/407 (26%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V PA ++++A K + +++ G ++ + G L Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEAL---PSYLGLKFEFTDLHAGFETFERTG--AAL 58 Query: 85 PAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P +T++++R E A+ G +++P G S VALR++LDLY +RPV+ P Sbjct: 59 PDKTVEILRNECDGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTVLSAAKP- 117 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 DMVI REN+ED+Y E D+ D + IK Sbjct: 118 -----IDMVIVRENTEDLYVKEETTRDTPDGK--------------------VAEAIKRI 152 Query: 202 SEEGTKRLVRAAIEYAIANDR------------DSVTLVHKGNIMKFTEGAFKDWGYQLA 249 SE + R+ A + A+ + VT+ HK N++ Sbjct: 153 SERASHRIATMAGDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL--------------- 197 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 + +K+VI D NL GD + Sbjct: 198 -------------------------LRLKNVIVD------------------PNLYGDIL 214 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD AA VG +G+ P AN+G+ A+ E HG+AP GQ+ NP + + SA +ML + Sbjct: 215 SDDAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIMGQNIANPIATLRSAALMLEFLDE 274 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I ++ + + D K +E + I+ + Sbjct: 275 EAAAAKIYAAVDANLTEGKL-----LSPDLGGTAKTTEVIEDILRRL 316 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 254 bits (650), Expect = 4e-66, Method: Composition-based stats. Identities = 86/412 (20%), Positives = 149/412 (36%), Gaps = 86/412 (20%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GD IG ++ LK++ E+ + +IS+ G S G + E L+ Sbjct: 9 VLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYG--LIGGASLDKTGS--AITDEVLE 64 Query: 91 LIREYRVAIKGPLTTPVGGGIRSLN------VALRQELDLYICLRPVRYYQGT---PSPV 141 + G + P + + LRQ LD + +RP R+Y + SP+ Sbjct: 65 TAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQSPL 124 Query: 142 KHPEL---TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 K PE+ D V+ REN Y G + + + Sbjct: 125 K-PEIAAGVDFVLVRENCGGAYFGTKTEFEDE---------------------------- 155 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVT---------LVHKGNIMKFTEGAFKDWGYQLA 249 + +R R + A R T K N++ + ++ + + Sbjct: 156 ---ARTEVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL-ASGRFWRTVTHDIF 211 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDY 308 EF +I + D +AD+ ++ P +++ VI N GD Sbjct: 212 EREF-------------------PDIELHDQLADSMAMVMVKAPTKFNGVIHTDNTFGDI 252 Query: 309 ISDALAAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 +SD VG +G+ P A++ ++EA HG+AP +G + NP + ILS Sbjct: 253 LSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSAPDISGTGQANPIAQILSLA 312 Query: 362 MMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 M+LR+ ADL+ + + + R D + GDA+ Sbjct: 313 MLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIRTKDLGGSASTQDVGDAV 364 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 253 bits (646), Expect = 9e-66, Method: Composition-based stats. Identities = 91/408 (22%), Positives = 154/408 (37%), Gaps = 71/408 (17%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GD G +V +KV+ A + K + G S + L E Sbjct: 6 IVVFGGDHCGPEVVLEAIKVLKAIETNSPSAG-KFNLQNHLLGGASIDKHNDP--LTDEA 62 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSL-----NVALRQELDLYICLRPVRYYQGT---PSP 140 L+ + + G + P G ++ + LR+EL Y LRP + + SP Sbjct: 63 LNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSP 122 Query: 141 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +K TD ++ RE + IY G + D Sbjct: 123 LKAEVCRGTDFIVVRELTGGIYFGDRTEDD----------------------GSGYACDT 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +P S R+ R A A+A + V + K N++ T ++ + +EF Sbjct: 161 EPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF---- 215 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 ++ ++ + D+ ++ P + V+ NL GD ISD + Sbjct: 216 ---------------PQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVI 260 Query: 317 VGGIGIAPGANIGDEC-------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MG 368 G IG+ P A++G ++E HG+AP +G+ VNP ILS MMLR+ + Sbjct: 261 PGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLN 320 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + AD + ++ AI+ T T D S+ G+A++ + Sbjct: 321 LPKEADAVEAAVKAAIDNGTKTKDL------GGNATTSDMGNAVVAEL 362 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 253 bits (645), Expect = 1e-65, Method: Composition-based stats. Identities = 82/346 (23%), Positives = 141/346 (40%), Gaps = 55/346 (15%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +++ V+ + I W +++ K G+DV + L+ + ++ IKGP + G Sbjct: 2 IESLVKVFSTVQVPIDW-DVFHEHKINSAEGEDV--SPKLLESLCRNKIGIKGPFES--G 56 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 +R LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 57 PCLR----KLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + EG R+ R EYA N+R +T+ Sbjct: 110 PGVMQ-----------------------TIKVSTAEGADRMARYVFEYAKKNNRKKITVA 146 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +I+ ++ D Sbjct: 147 HKANIMRLTDGTFLSPMRREAAKY-------------------QDDIMFEERYLDTVCLA 187 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 +L++P DV+ ++ GD ++ A+ +GG + PG +G ++E T AG+ Sbjct: 188 MLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPGFAVGPMGLIYEPIIHTNTNIAGK 247 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA-KTVTYDF 393 D VNP ++LS +MLR M E AD I + T D Sbjct: 248 DIVNPTGMLLSGVLMLREMKLNEYADKICCAVSTVFRETDCRTKDL 293 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 250 bits (639), Expect = 6e-65, Method: Composition-based stats. Identities = 99/381 (25%), Positives = 162/381 (42%), Gaps = 57/381 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG ++ P + + + I+++ + G + + + Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS--------DINFVTFDISSERYIKTG--IIIKDDE 53 Query: 89 LDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 L+ ++ YR + G + P G + + + LR+EL+LY+ +RPVR + + Sbjct: 54 LEELKNYRAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------D 104 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 + I REN++D Y I + V E G G+ Sbjct: 105 KIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGML-------- 156 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R ++ A + +VT+ K N +K ++ + A E Sbjct: 157 SYRYLKKFFNKAFSICDSTVTVTDKANAVKMYN-LWRSTAMEAAIE-------------- 201 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 K I I ADA ++L P +Y I NL GD ISD AA VGG+G AP Sbjct: 202 -------KNINISFEYADALAYNMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPS 254 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME---- 381 ANIGD+ ALFE HG+AP AG+D NP + I++ M+L ++G+ + + +I + Sbjct: 255 ANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYLGYRDESRIINDMVRNLYI 314 Query: 382 -GAINAKTVTYDFERLMDGAK 401 G N++ + ER M K Sbjct: 315 NGVFNSERTSKIIERFMTITK 335 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 243 bits (620), Expect = 1e-62, Method: Composition-based stats. Identities = 97/429 (22%), Positives = 164/429 (38%), Gaps = 98/429 (22%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG +V A ++A A ++ W + +PA+ Sbjct: 10 VAVMPGDGIGPEVMAATRHALEALPGPALVL-TELGWPAHAWHRDHGE------MMPADW 62 Query: 89 LDLIREYRVAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 + Y + G L P G + + LR+ LDL+ C RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 138 PSPVKHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ P TD+++ RENSE Y ++ G P Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTPRETA 163 Query: 196 IGIKPCSEEGTKRLVRAAIEYA----------IANDR---------DSVTLVHKGNIMKF 236 ++ + GT+R++R A E A + R +V +V K N +++ Sbjct: 164 TQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQY 223 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 + + ++A E I + DA + + +P ++ Sbjct: 224 AGELWSEVFAEVAAEY--------------------PGIATHHELIDACCMKFVSQPWQF 263 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE----CALFEATHGTAPKYAGQDKVN 352 DV+ NL+GD ++D A GG+G+AP AN+ LFE THG+AP AG D+ + Sbjct: 264 DVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGADRAH 323 Query: 353 PGSIILSAEMMLRHMGWTE-----AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 P +++L+A ML MG + +A + + + I G C+E Sbjct: 324 PAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAEH-----------GMGGRGCAE 372 Query: 408 FGDAIIENM 416 G A+ + + Sbjct: 373 VGRAVAQRI 381 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 239 bits (609), Expect = 2e-61, Method: Composition-based stats. Identities = 94/397 (23%), Positives = 152/397 (38%), Gaps = 71/397 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGI +++ A+ V DA +I ++ + ++S + G ++ Sbjct: 7 NRYSIVELHGDGIARELSQAVHTVADAL-------PFEIEFIPVDLSDESREAKGDAIY- 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E +R Y ++K P T S N LR+ + + RPV G + + Sbjct: 59 -DEAEAAMRRYGTSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQT--HYN 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E + I R + Y R + I+ Sbjct: 112 ERIHLDIVRIATGGTY-----------------------EDAGRRINRDTAVSIRAIERR 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 + R A A D +V K I K T+G F++ +AR+ E Sbjct: 149 PSVLASRFAFRLAQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDYPATE-------- 199 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + DA L I++RP Y VI C N GD++SD +G IG+ Sbjct: 200 ------------FREELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGLIGSIGLGD 247 Query: 325 GANIGDE------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 A+ + A+F+ GTAP AGQ+K NP + +L+ MLRH+G +++ + Sbjct: 248 SASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAMANMLRHIGEHDSSKALRG 307 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + GAI A T D L SEF I++ Sbjct: 308 ALFGAIEAGEKTADI------GGSLNLSEFTQVIVDR 338 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 238 bits (606), Expect = 4e-61, Method: Composition-based stats. Identities = 81/415 (19%), Positives = 149/415 (35%), Gaps = 79/415 (19%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 NGK P + IEG G G V A+ K+ AA+ E + +Y K+ ++ Sbjct: 34 NGKAQRPIR--VTVIEGQGTGPVVLAAVRKIFKAALVPV---EWDYQTLSVYRDHKTNRM 88 Query: 78 YGQDVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + + LD E + + ++P + S ++AL + L+ ++ +R G Sbjct: 89 T-----VNPQLLDSAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG 143 Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + ++V RE+ Y+ IE + Sbjct: 144 ----HEPYGPINLVNIREHVSGEYSEIEHLVSPGVVQ----------------------- 176 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 IK S++ + + + A +YA + +T++HK ++M+ ++G F +++ Sbjct: 177 SIKTVSKKISVEVAKLAFDYACKHGHSRITVLHKADVMRLSDGIFLKACREVSACY---- 232 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + D+F + P Y+V+ +L G + Sbjct: 233 ----------------PDVEYNEEKLDSFCLNVTTNPGRYEVLLTTSLYGAFAGSVCGMM 276 Query: 317 VGGIGIAPGANIGDECALFEA---------THGTAPKY------AGQDKVNPGSIILSAE 361 GG+ P G + +F +H + +NP II +A Sbjct: 277 SGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYGQEQIINPTGIIRAAA 336 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +ML H G A I +E I T D CS+F DAII+N+ Sbjct: 337 LMLDHAGMVVAGRCIAAAVEDTIRQGIRTQDM------GGDASCSQFTDAIIKNL 385 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 80/423 (18%), Positives = 149/423 (35%), Gaps = 90/423 (21%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 ++ + P+ + ++GD IG +V +L + D K+ E G Sbjct: 3 RSSGKDAPKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSH---FGIKVETFERLIGGSCLD 59 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTP---VGGGIRSL---NVALRQELDLYICLRP 130 + D + TL E + G + P VG R + +R+ L+LY +RP Sbjct: 60 QH--DCPIQESTLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRP 117 Query: 131 VRYYQGTP---SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 + S +K +++ REN+ IY G + + D Sbjct: 118 AKIISERQLELSSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH------------- 164 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 +AA+ A ++ + V K N+M T ++ Sbjct: 165 -------------------------KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVV 198 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNL 304 + R+EF + + + D+ + P + + V+ NL Sbjct: 199 TETIRDEFPQLMDK-----------------LSHQLVDSAAMLLAKDPRKLNGVVLTENL 241 Query: 305 NGDYISDALAAQVGGIGIAPGANI-GDEC---------ALFEATHGTAPKYAGQDKVNPG 354 GD +SD + G +G+ A I G +++ G+AP AG+ NP Sbjct: 242 FGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIANPI 301 Query: 355 SIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + +S +M R +G +AAD I ++ + + T D L + G A+ Sbjct: 302 GMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV------GGTLSTQQAGSALR 355 Query: 414 ENM 416 +++ Sbjct: 356 QSI 358 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 222 bits (566), Expect = 2e-56, Method: Composition-based stats. Identities = 88/406 (21%), Positives = 152/406 (37%), Gaps = 56/406 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + E ++ + G+G+G +V L ++ E G+R G ++ + Sbjct: 18 RGTGTERGEAFLVGVLPGEGVGPEVIDVALSLLRLLGEAT--GQRFEVRTGGPIGRQAER 75 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + G+ L E D + L P GG LR+ DLY L P+R++ Sbjct: 76 LTGRG--LTPEVRDFCAQVFAQGGAVLCGPGGGRFVY---DLRRHFDLYCKLIPLRHWPA 130 Query: 137 T-PSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + V PE D++I REN+ +Y G EW ++ A R V + R E Sbjct: 131 LADAGVLRPEAARSADVLIVRENASGLYCG-EWGSEGEGAA------RSAYQVCRYRADE 183 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +R++R A+ A R + +V K + + D +A E Sbjct: 184 -------------VERILRTALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGEH 229 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + + + D Q++ P ++DVI C N+ GD + D Sbjct: 230 GA--------------------VRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGDC 269 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 + +G G++ N G A+++ HG A AG+D+ NP + S MMLR Sbjct: 270 GSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLRESFRLP 329 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + + T D + + G A+ ++ Sbjct: 330 ALADALETAIARTLARGVRTADIQGAQP--TAVGTRAMGQALCASL 373 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 217 bits (552), Expect = 7e-55, Method: Composition-based stats. Identities = 92/382 (24%), Positives = 147/382 (38%), Gaps = 52/382 (13%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 93 G+GIG ++ ++ V+ A++ GE ++ + G ++ G+ V P ET + I Sbjct: 14 GEGIGPEIVAPTVQAVELALQA--SGEATPEFVPLLLGREAINATGRIV--PEETWETIT 69 Query: 94 EYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 149 I GP P G + + LR++ DL+ +RPVR G P D+ Sbjct: 70 GLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP-----DLDV 124 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 209 VI REN+E +YA S D + + + + Sbjct: 125 VIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAIAAARD---- 180 Query: 210 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNP 269 +T+ HK N++ T G + A E Sbjct: 181 -------------GVLTVAHKSNVLTETSGRYVAEAKACAEEF----------------- 210 Query: 270 NTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329 + ++ V DA +++ RP Y I N+ GD +SD G +GIA N Sbjct: 211 ----GVEVQPVHIDALCAELVTRPERYATIVAENMFGDILSDLAGGLGGSLGIAGSINAS 266 Query: 330 DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTV 389 + + +A HG+AP AGQ NP I+ SA ML +G+ +AA+L+ + A+ K Sbjct: 267 ESQVMAQAAHGSAPDIAGQGIANPAGIMNSAAQMLDSLGYPQAAELLEGAVREAV-VKAP 325 Query: 390 TYDFERLMDGAKLLKCSEFGDA 411 T D R A + D Sbjct: 326 TADLVREAAAADPETATPVADE 347 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 93/413 (22%), Positives = 148/413 (35%), Gaps = 72/413 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME------IYTGEKSTQVY 78 + I I DG+G DV P K + A E E + E + TG+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYEAGVEYAVKTGKMCEDNL 61 Query: 79 GQDVWLPAETL-DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 G+D+ L Y + G++ L LR + I LRP+R +G Sbjct: 62 GEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQF-LRSGMGNSIGLRPLRLRKGI 120 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+++ E D+++ R+ +E Y E Sbjct: 121 DCPLRNREEIDVLLVRQLAEGFYIRPGH-----------------------MIGEDAAYD 157 Query: 198 IKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHK-GNIMKFTEGAFKDWGYQLAR 250 + T++ A + + VTL +K GN+ F D+ ++ Sbjct: 158 TIVVTRNVTEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCF------DFYRKIFT 211 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 E G +I ++ DA + ++ P +DVIAC N+ GD I Sbjct: 212 EVSAG----------------YPDIGLQFTQVDALAEHLIKDPDRFDVIACENMIGDIIG 255 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-- 368 D A GG+GI P A++G F HGT P+ G+ NP + IL+A ++L +G Sbjct: 256 DIGAYITGGMGITPTADVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTLGNE 315 Query: 369 -----WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A LI K +E + T R D +A+ + M Sbjct: 316 RGDDNLRRGARLIEKAVEYNL-----TTGGPRTKDLGGTANTFATAEAVFKAM 363 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 210 bits (535), Expect = 7e-53, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 129/362 (35%), Gaps = 73/362 (20%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V A +A E ++W + V + Sbjct: 16 YKIAAIRGDGIGPEVIEAGNY--QSAEETNRVAWILLNWPS--------RTLSGAVRITR 65 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 T D+ P+++ S + LR + P R + G SP+ Sbjct: 66 NTADI---------SPISSSTFLWFSSY-LPLRSST---SNM-PTRVFHGIQSPLH---- 107 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D VI RENSE YAG G P I + G Sbjct: 108 LDWVIVRENSEGEYAGHG-------------------GRSYAGKPWEVATDISIFTRHGV 148 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+++ A E A + + +T+ K N + ++A E + Sbjct: 149 ERIMKFAFEAARSRAKKHITVATKSNAQRNG----LVVWDEIAAAEVAAQF--------- 195 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ ++ DA +++L P D I NL+ +SD +A G IGIAP + Sbjct: 196 ------PDVTCDKMLVDAMTARVVLTPESLDTIVPTNLHAGILSDLASALAGSIGIAPTS 249 Query: 327 NIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N+ ++FE HG+A AG+D + ML +G AA +++ +E Sbjct: 250 NLDPTRENPSMFEPVHGSAFDIAGKDLA----TFWTVAEMLSWLGQKGAAAELLECVESV 305 Query: 384 IN 385 Sbjct: 306 CK 307 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 145/420 (34%), Gaps = 68/420 (16%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 ++L+NG I I GDG+G ++T + + A E R + E G Sbjct: 3 DIVSLRNGS----RIYTIALIPGDGVGPEITREAVLTLKRAGE---VYGRSFQFTEAIAG 55 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR------SLNVALRQELDLY 125 + LP E+L E + G L G++ S+ LR L L Sbjct: 56 TAALDR--GQCPLPRESLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLR 113 Query: 126 ICLRPVRYYQGTP--SPVK---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +RP + + P+K + D++I R+ + ++ Sbjct: 114 SDIRPCFFAEALRELCPLKEEIRKKGMDILIIRDIAGGMFT------------------- 154 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 G + E + R A + A + R VT + K I+ + Sbjct: 155 -TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQLAASRKRK-VTSLDKA-ILLSSSVL 211 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 ++ + R+ EI ++ ++ D +++ P +DVI Sbjct: 212 WRQILEETHRDY--------------------PEIELEHMLVDHGAFKLVSSPDAFDVIV 251 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEA--THGTAPKYAGQDKVNPGSII 357 N+ GD I+D A G P ++ + ++ H + AG + NP +I Sbjct: 252 ASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPVGMI 311 Query: 358 LSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L+A MML + G A+ + + + + G + + G+A+ E + Sbjct: 312 LAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGR--PCWSGGEQTADTAAIGEAVRECL 369 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 179/404 (44%), Gaps = 52/404 (12%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I L L +P++ I YIEGDG G ++T AM+ V++A+E AY G + I W +IY G Sbjct: 2 YIKLDGNHLIIPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGR 61 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + YG+ +LP E+++ IR+ +KGPL++ + G +N+ +++ L+LY ++ + Sbjct: 62 EAYEKYGK--YLPRESIEDIRKTVFVMKGPLSSNING--HDININIKRILNLYTDVKCIT 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G E ++ IF + +++Y + DS D++ + ++L++ + Sbjct: 118 GLPGLS------EGKEIFIFSPSIDEVY---HFSYDSEDSDMLRQYLQQSFNIS---IGG 165 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 I +K S R+++ A + A + L ++ Sbjct: 166 DSDIFLKGTSRY---RIIKIASKIAE-------------------ISSLYGIKRTLVADD 203 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + G + + EI + D + + +++ + I Sbjct: 204 YTGSHAPLWVYNTLNKMEMPVEIENLYNLYDEMTSE-----SRFNIFIPDSRLSSLIIKI 258 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + A+ GA +GD +LFE+ + G D +P S +L++ MMLR + + +A Sbjct: 259 INART-----FFGAILGDFISLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDA 313 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ + + ++ LKCS+F DAI++ M Sbjct: 314 ALILRNALNSVYSDGI----LPASLNLNNGLKCSDFIDAIVKRM 353 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 191 bits (486), Expect = 3e-47, Method: Composition-based stats. Identities = 79/381 (20%), Positives = 130/381 (34%), Gaps = 96/381 (25%) Query: 37 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 I +VT A+ +V+DA Y E L E +D IR+ + Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYF-------------ETYIIKGKNMNHLTWEVVDSIRKNK 54 Query: 97 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 156 V + G + + GG R+ELDL+ L G PS E D+V+ REN+ Sbjct: 55 VCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS---RHENVDIVVIRENT 104 Query: 157 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 216 E YAG E + E ++ + R+ + A EY Sbjct: 105 EGEYAGREHEVVPGVIESFQVT----------------------MTKFWSDRIAKYAFEY 142 Query: 217 AIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEI 275 A + R VT VH G K + F + ++A+ I Sbjct: 143 AHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMY--------------------PNI 182 Query: 276 VIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF 335 + + + + R + + I++ + GG + GD+ A+F Sbjct: 183 TYNE--IASRETRAIRRHSNSKSLWA------IIANIASGVAGG-------SFGDDYAIF 227 Query: 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFER 395 E + NP +++ S+ MMLRH+ AD + + I+ Sbjct: 228 EQVGSVG------NHKNPVALLFSSVMMLRHLLLPLFADRLKTAVTRVISEGKC------ 275 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 G E D++I N+ Sbjct: 276 ---GNSNTTTQEVVDSVIANL 293 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 190 bits (483), Expect = 7e-47, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 112/303 (36%), Gaps = 62/303 (20%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 +N P I I GDGIG ++ + ++V+ AA + + ++ + G + + G Sbjct: 1 MNAPHALDIAVIPGDGIGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTGS 56 Query: 81 DVWLPAETLDLIR-EYRVAIKGPLTT-----PVGGGIRSLNVALRQELDLYICLRPVRYY 134 + A TL+ IR Y +KGP+ P G L LR LD Y +RP+ Sbjct: 57 --AMSAATLERIRTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALL 114 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G +P++ D VI REN+E +Y + + Sbjct: 115 PGVDAPLRG-TAVDYVIVRENTEGLYLSRGRGVGN----------------------DRA 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 + G +R+V A E A VT V K N+++ + F++ ++ Sbjct: 152 CADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEV 210 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A ++ ADA ++ P +DV+ N GD Sbjct: 211 ATRY--------------------PQVEADHRYADAAGHDLVADPGRFDVLVMENFLGDI 250 Query: 309 ISD 311 +SD Sbjct: 251 LSD 253 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 190 bits (483), Expect = 7e-47, Method: Composition-based stats. Identities = 60/183 (32%), Positives = 85/183 (46%), Gaps = 27/183 (14%) Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 + ++G F +A++ EI ++ D ++ P Sbjct: 112 RMSDGLFLRCVRDMAQK--------------------FPEIQFEEKYLDTVCLNMVQNPG 151 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 +YDV+ NL GD +SD A VGG+G+ P N+G ALFE+ HGTAP AG+D NP Sbjct: 152 KYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPT 211 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAII 413 +++LSA MMLRHM AD I + I K +T D KCSEF + I Sbjct: 212 ALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDL------GGRAKCSEFTNEIC 265 Query: 414 ENM 416 + Sbjct: 266 AKL 268 Score = 51.2 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 19/45 (42%), Gaps = 7/45 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 + I GDGIG +++ A+ K+ AA I W + Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDV 84 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 82/408 (20%), Positives = 145/408 (35%), Gaps = 78/408 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P I + GD G ++ L+V+ +V + + + +++ ++ + V Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIR-----QPLQFLDYDLSLENRRATDNKVV-- 57 Query: 86 AETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRP------VRYYQGTP 138 E R+ +++K TP + G + S N LR+ L+ + LR +R G Sbjct: 58 WEAAQAARDSGLSLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVY 117 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 SP + I R +D Y EW+ + + + Sbjct: 118 SP--------IAIVRMAVDDAYGSKEWRETTENG-------------------DEIAYRT 150 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S + + +YA + V K + EG FK+ A+ Sbjct: 151 SKISRSTCRAVAEFTFQYA-KRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRY------ 203 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 E+ + ++ DA +L E VI +N +GD +SD + G Sbjct: 204 --------------PEVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDMVLQMYG 249 Query: 319 GIGIAPGANIGDECA-------LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH--MGW 369 I + +G E + EA HGTAP G++ NP ++IL+ +L + + Sbjct: 250 SIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLSYGRIPQ 309 Query: 370 TEAADL-IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E A I + + I T D + SEF D +I + Sbjct: 310 AEKASRAIYESVFETIYEGKATPDL------GGQMTTSEFTDEVIRRV 351 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 79/399 (19%), Positives = 130/399 (32%), Gaps = 86/399 (21%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GD G +V +KV+ A + K + E G S +V+ + A Sbjct: 6 IVVFGGDHCGPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAKALA 64 Query: 89 LDLIREYR--VAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGT---PSPVK 142 + AI GP P + LR+EL Y LRP + + SP+K Sbjct: 65 AAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDSSPLK 124 Query: 143 HP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 TD ++ RE + IY G + D + Sbjct: 125 ADVCRGTDFIVVRELTGGIYFGARTEDD----------------------GSGFAMDTDA 162 Query: 201 CSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 S +R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 163 YSRAEIERIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF------ 215 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQVG 318 ++ + + D+ ++ P + V+ NL GD ISD + G Sbjct: 216 -------------PQLEVGHQLIDSAAMLMVKSPRALNGVVVTSNLFGDIISDEASVIPG 262 Query: 319 GIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIV 377 IG VNP ILS MMLR+ + + A + Sbjct: 263 SIG--------------------------AGIVNPIGTILSVAMMLRYSLNLPKEAAAVE 296 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A++ T T D + DA++ + Sbjct: 297 AAVRTALDNGTRTKDL------GGSAGTFQMADAVVVEL 329 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 123/337 (36%), Gaps = 55/337 (16%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRF---P 161 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDYCS---------- 248 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I ++ + D + +++ PA +D I + +++ + GG + Sbjct: 249 ---------IKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSA 299 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 +GD A+F+ T ++P I+ + +L H+G A + KGM + Sbjct: 300 IELGDSHAVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQESCAKSLWKGMLRTMT 358 Query: 386 AKTVTYDFE-------RLMDGAKLLKCSEFGDAIIEN 415 T +F+ + + L+CS G+ + + Sbjct: 359 DGIKTVEFDGPDTGEYVICNIMNKLRCSALGENVEKK 395 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 112/309 (36%), Gaps = 53/309 (17%) Query: 107 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166 V + ++ L +LDLY+ VR + G ++ I +N+ +Y+ +E+ Sbjct: 117 VDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRF---PDVNIRIIAQNNMGVYSDLEYS 173 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 E I ++EG ++ +R A A+ +R VT Sbjct: 174 PVKGVVE-----------------------AISVSTQEGNEKYLRKAFATAVKANRKRVT 210 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 L+HK T+GA ++ ++ + ++ + + + Sbjct: 211 LIHKSTEWPITDGAMVSAAKEIHKDYEHC-------------------LELELMNVEDCI 251 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 +++ P E+D I + I+ + GG + IGD A+F+ Sbjct: 252 GRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFSAVEIGDFHAVFKPLQ-VKLSLT 310 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDF-------ERLMDG 399 ++P I+ + + H+G+TE D + + M + + T DF + + Sbjct: 311 NYPILSPYGIVNTIVDLFDHLGYTECGDALWEQMLRTMESGIKTKDFGGEDSGEYVICNI 370 Query: 400 AKLLKCSEF 408 L+C F Sbjct: 371 INRLRCRGF 379 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 87/410 (21%), Positives = 143/410 (34%), Gaps = 72/410 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +PE I +EGD G ++ ++V+D + ++ + V Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGV 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTP--S 139 ++ +R IK TP G + S N LR+E+D + +R R G + Sbjct: 56 V--SDAAAAMRTCGFGIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIA 113 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V +P + I R ED Y +W+ A A + + E Sbjct: 114 GVHYP----ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEH----------------- 152 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + + + A A A M+ W E E +D Sbjct: 153 -VTRSTCRAVSEYAFRTARA--------------MQARVYGGPKWTVSPVYEGMLKEEMD 197 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILL-RPAEYDVIACMNLNGDYISDALAAQVG 318 ++ + V+ DA ++ E V+ +N +GD +SD + G Sbjct: 198 AAAAR-------HPDVAYEPVLIDATYAGLVSGAADEPLVVPALNRDGDCLSDLVLPMFG 250 Query: 319 GIGIAPGA------NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM----- 367 I A N A+ EA HGTAP G+D NP +++L++ +LRH Sbjct: 251 SIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVANPMAMLLASGAVLRHAAERGH 310 Query: 368 -GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G A+ I + + AI T D +EF DA+IE + Sbjct: 311 PGAERASRAIYESVLEAIATGIKTPDL------GGHAGTTEFTDAVIERI 354 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 175 bits (444), Expect = 2e-42, Method: Composition-based stats. Identities = 77/400 (19%), Positives = 136/400 (34%), Gaps = 74/400 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G +V +++ E+ GE ++ G ++ G LPA T Sbjct: 4 VALLPGDGVGEEVLDGPTRLLRLLAER---GEVEV-TGPWPVGARAAAETGD--VLPAGT 57 Query: 89 LDLIREYRVAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTPSPVK 142 L + G + P G R LR+ DL I +R + Sbjct: 58 LAACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVR----------EIP 107 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + ++ + R Y G + + D + LR + Sbjct: 108 FADGRELTVVRNLIGGSYGGADDRVLREDGSEAADVLR--------------------LT 147 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E +V A + + V K N + T ++ +ARE Sbjct: 148 RERVAEVVHTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARER---------- 196 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 I ++ D ++ DV+ L GD +SD A + G + Sbjct: 197 -----------GIEVEHRYVDRAAFELGSGAPVPDVLVTEGLLGDILSDLAAGRAGSPAL 245 Query: 323 APGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA-D 374 A++ G LFE HG+AP+ A +D+V+P L+ +LRH T A + Sbjct: 246 CGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPLGGFLALAALLRHFPATREAGE 305 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 + + + + TYD + +G + DA++ Sbjct: 306 RVRAAVGAVLRSGPWTYDL--VPEGGAAASTGQVADAVLA 343 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 168 bits (426), Expect = 3e-40, Method: Composition-based stats. Identities = 53/133 (39%), Positives = 71/133 (53%), Gaps = 6/133 (4%) Query: 285 FLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAP 343 F + ++ P+++DV+ NL GD +SD A +GG+G+ P NIG A+FE+ HGTAP Sbjct: 26 FSRGMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAP 85 Query: 344 KYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLL 403 AG+D NP +++LSA MMLRHMG A I I K V D Sbjct: 86 DIAGKDMANPTALLLSAVMMLRHMGLHGHAKKIETACFDTIRDKKV-----LTKDLGGNP 140 Query: 404 KCSEFGDAIIENM 416 KCSEF I + Sbjct: 141 KCSEFTADICRRV 153 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 159 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 134/370 (36%), Gaps = 54/370 (14%) Query: 74 STQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN--VALRQELDLYICLRPV 131 +TQ Y V T D R +K +P G IR++ R+ + IC Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSP-NGTIRNILGGTVFREPI---ICKNIP 158 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 R G P + I R D Y ++ AD A K++ ++ GVK+ Sbjct: 159 RLVPGWTKP--------ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVY 210 Query: 192 EHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 G+ ++E + +YAI + + + K I+K +G FKD ++ Sbjct: 211 NFPAGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEI 269 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + + + W + + D + Q+L + V AC N +GD Sbjct: 270 FDKHYKTDFDKNKIW-------------YEHRLIDDMVAQVLKSSGGF-VWACKNYDGDV 315 Query: 309 ISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILSA 360 SD LA G +G+ + + EA HGT ++ + + NP + I + Sbjct: 316 QSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAW 375 Query: 361 EMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK-------CS 406 L H G A ++ K + + +T D + G +K + Sbjct: 376 TRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTT 435 Query: 407 EFGDAIIENM 416 +F D I N+ Sbjct: 436 DFLDTIKSNL 445 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 158 bits (399), Expect = 4e-37, Method: Composition-based stats. Identities = 68/393 (17%), Positives = 128/393 (32%), Gaps = 68/393 (17%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDG G + + + +D K+S + + LP+ Sbjct: 10 FQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGA---GTALPS 66 Query: 87 ETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG--TPSPVKH 143 TL R+ + P G + LRQEL+ + +RPVR+ Sbjct: 67 TTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSSYK 126 Query: 144 PELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 PE+ D+ FR+ + +Y G +A + P Sbjct: 127 PEVVEQLDITFFRDLTSGVYYGRRKEAG----------------------DDGEAYDTTP 164 Query: 201 CSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 S + +R+ R A YA+ + V + K N+M T ++ + EF Sbjct: 165 YSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF------ 217 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQVG 318 ++ ++ V+ D + P + +I N+ GD +SD +G Sbjct: 218 -------------PQVPLRHVLVDTASMILSSDPLSLNGIILTENMFGDILSDQAGGILG 264 Query: 319 GIGIAPGANIGD--------ECALFEATH-GTAPKYAGQDKVNPGSIILSAEMMLR-HMG 368 + A + +FE + K G P I + +ML +G Sbjct: 265 SPDVLASAAVSAIRRGGSRGTPGIFEPFNLNPGGKTVG-----PLGSIQAVGLMLELSLG 319 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 ++ + K + ++ + R +D Sbjct: 320 LAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 157 bits (397), Expect = 7e-37, Method: Composition-based stats. Identities = 51/185 (27%), Positives = 84/185 (45%), Gaps = 13/185 (7%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + + A +L P+ + G G+G +++ A+ + +AA + Sbjct: 8 YASSAIRATASPRSLSTSASTSPQ-FTVTLFPGHGVGPEISVAVQNIFNAA-------DV 59 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W E + + GQD + A+ LD +R R +KGP+ TP+G G RSLN+ LR+ Sbjct: 60 PIVWDEHHI-DVDNAKPGQD-LISADALDSLRRNRFGLKGPMATPIGKGYRSLNLTLRKA 117 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RP G +P + D+V REN+E Y+G+E E + E Sbjct: 118 LGLYANVRPCVSIPGVQTPY---DDVDVVTVRENTEGEYSGLEHVVYPGVVESLKVITPE 174 Query: 182 EMGVK 186 + + Sbjct: 175 RVNAR 179 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 145 bits (366), Expect = 2e-33, Method: Composition-based stats. Identities = 51/185 (27%), Positives = 86/185 (46%), Gaps = 33/185 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +++ +++K+ DAA + + + G + G+ +P Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAA-------KVPVEFETENAGSDVYEKTGE--LIPES 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + Sbjct: 54 LYESVERNKIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNI 110 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+ IFREN+E IY G E + I +K +++G++ Sbjct: 111 DLAIFRENTEGIYIGEEKYENEEKT---------------------SAIAVKRITKKGSE 149 Query: 208 RLVRA 212 L++ Sbjct: 150 ELLKV 154 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 80/424 (18%), Positives = 141/424 (33%), Gaps = 70/424 (16%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAV-EKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +V+ A + EK I M + V + + Sbjct: 187 PVVEMDG------DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTI--DA 238 Query: 89 LDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPV------RY 133 I+ + V +K TP ++ S N +R LD I P+ R Sbjct: 239 ALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPILMKNVPRL 298 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 P ++I R D Y +++ D + ++ + E Sbjct: 299 VPSWTKP--------IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEF 350 Query: 194 CGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 G G+ ++ K + +YA+ + L K ++K +G FKD + Sbjct: 351 KGGGVALGMYNTDASIKGFAHSCFQYALDQKMP-LYLSTKNTVLKKYDGRFKDIFQTIYE 409 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 +E+ + + G W + + D + Q + + V AC N +GD S Sbjct: 410 KEYKQKFEEAGLW-------------YEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQS 455 Query: 311 DALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILSAEM 362 D +A G +G+ + + EA HGT ++ Q + NP + I + Sbjct: 456 DVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTR 515 Query: 363 MLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK-----CSEFGD 410 L H E + + + A +T D + G KL +F D Sbjct: 516 SLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMD 575 Query: 411 AIIE 414 + Sbjct: 576 KLAR 579 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 128 bits (321), Expect = 4e-28, Method: Composition-based stats. Identities = 83/433 (19%), Positives = 148/433 (34%), Gaps = 75/433 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 +NPI+ DG M +V+ + +K ++ G V Sbjct: 9 QNPIVEM---DG------DEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVT 59 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV--- 131 + E+ + ++Y VAIK TP + RS N +R L+ + P+ Sbjct: 60 V--ESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCK 117 Query: 132 ---RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI---KFLREEMGV 185 R G P + I R D Y + A K++ + E+ Sbjct: 118 NIPRLVPGWTKP--------ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEF 169 Query: 186 KKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244 + F G+ + + + + R A++ A + + L K I+K +G FKD Sbjct: 170 EVYNFTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDI 228 Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 ++ + + + G W + + D + L Y V AC N Sbjct: 229 FQEVYEANWKSKYEEAGIW-------------YEHRLIDDMVAYALKSEGGY-VWACKNY 274 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYA------GQDKVNPGSI 356 +GD SD LA G +G+ + + EA HGT ++ G+ N + Sbjct: 275 DGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIAS 334 Query: 357 ILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK----- 404 I + L H + + + GA+ + +T D ++ L Sbjct: 335 IFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYL 394 Query: 405 -CSEFGDAIIENM 416 EF DA+ + + Sbjct: 395 NTEEFIDAVADEL 407 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 125 bits (314), Expect = 3e-27, Method: Composition-based stats. Identities = 63/371 (16%), Positives = 129/371 (34%), Gaps = 55/371 (14%) Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLN--VALRQELDLYICLR 129 ++ + YG V T D R +K +P G IR++ R+ + + Sbjct: 117 AEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSP-NGTIRNILGGTVFREPI-----VI 170 Query: 130 PV--RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR--EEMGV 185 P R G P ++I R D Y + +++ + V Sbjct: 171 PAIPRLVPGWTKP--------IIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPESV 222 Query: 186 KKIRFPEHCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244 + F G+ + +++ + ++ + A+ + + K I+K +G FKD Sbjct: 223 QVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNTILKRYDGRFKDI 281 Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 ++ E+ E K I + + D + Q++ + ++A N Sbjct: 282 FQEIYEAEYKKEFD-------------AKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNY 327 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSI 356 +GD SD +A G +G+ + + F EA HGT ++ + + NP + Sbjct: 328 DGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQKGRETSTNPIAS 387 Query: 357 ILSAEMMLRHMGWTE-------AADLIVKG-MEGAINAKTVTYDFERLMDGAKL---LKC 405 I + L G + A+ + + +E +T D + + Sbjct: 388 IFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTT 447 Query: 406 SEFGDAIIENM 416 E+ A+ + Sbjct: 448 REYMAAVERRL 458 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 125 bits (313), Expect = 4e-27, Method: Composition-based stats. Identities = 69/412 (16%), Positives = 144/412 (34%), Gaps = 60/412 (14%) Query: 43 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV--TKDAAEAIKKHNVGVKC 73 Query: 102 PLTTPVGGGI---------RSLNVALRQELDLYICLR---PVRYYQGTPSPVKHPELTDM 149 TP + +S N +R L + R + S P + Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVF-REAIICKNIPRLVSGWVKP----I 128 Query: 150 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI---RFPEHCGIGIKPCSEEGT 206 +I R D Y ++ ++ + F E G+ + +++ + Sbjct: 129 IIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKS 188 Query: 207 -KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + ++ + A++ + L K I+K +G FKD ++ +++ + W Sbjct: 189 IEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW-- 245 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + + D + Q + + + AC N +GD SD++A G +G+ Sbjct: 246 -----------YEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLGMMTS 293 Query: 326 ANIGDECAL--FEATHGTAPKY-----AGQDKV-NPGSIILSAEMMLRH---MGWTEA-- 372 + + EA HGT ++ GQ+ NP + I + L H + + Sbjct: 294 VLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELA 353 Query: 373 --ADLIVKGMEGAINAKTVTYDFERLMDGAKLL------KCSEFGDAIIENM 416 A+ + + I A +T D + G + EF D + EN+ Sbjct: 354 FFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENL 405 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 118 bits (295), Expect = 5e-25, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 79/226 (34%), Gaps = 27/226 (11%) Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E + S++G + +R A + A R VTL++K ++G+ + +L Sbjct: 13 EGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCH 72 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 ++ + + +++ P +D + ++S Sbjct: 73 YKDCLELELMEVEE-------------------AISRLMTEPTYFDCLFASERYATFLSA 113 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG + IGD A+F+ T ++ I+ + + +H+G + Sbjct: 114 ICSGVCGGANLFSAVEIGDHHAVFKPLQ-TKLSLTNYANLSAYGIVSTIVDLFQHLGHDK 172 Query: 372 AADLIVKGMEGAINAKTVTYDF-------ERLMDGAKLLKCSEFGD 410 AD + ++ +N T +F + + L+C G Sbjct: 173 CADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLRCRALGK 218 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 108 bits (271), Expect = 3e-22, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 50/134 (37%), Gaps = 11/134 (8%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 P+ + T++ P+ I + GDGIG +V V+ A + + E Sbjct: 24 PSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAGS---LEGIEFGFQE 80 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQE 121 + G + + G V LP ETL + ++ + G + + + LR Sbjct: 81 MPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSG 138 Query: 122 LDLYICLRPVRYYQ 135 L ++ LRP Sbjct: 139 LKVFANLRPASVLP 152 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 108 bits (269), Expect = 4e-22, Method: Composition-based stats. Identities = 65/402 (16%), Positives = 133/402 (33%), Gaps = 47/402 (11%) Query: 43 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 M +++ ++ + G V + ++ + + VA+K Sbjct: 48 DEMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQVTV--DSAEATKRLGVAVKC 105 Query: 102 PLTTPVGGGI---------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 152 TP + +S N +R LD + P+ +G P + + + Sbjct: 106 ATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRGID-PCVKNWVRPITLA 163 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLRE--EMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 R D+Y E + +++ + E F E + + + Sbjct: 164 RHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVVEGMHNLDASIESFA 223 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 RA ++A+A +D V K I K + FKD ++ ++ G Sbjct: 224 RACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAARFEAAG--------- 273 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD 330 I + D + +++ + + AC N +GD +SD +++ G + + Sbjct: 274 ----IEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTSVLASP 328 Query: 331 E-CALFEATHGTAPKYAGQDKV------NPGSIILSAEMMLRHMGWTE-------AADLI 376 +EA HGT ++ + N + I + LR + AD + Sbjct: 329 HGYWEYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADLAAFADAL 388 Query: 377 VKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIENM 416 + I + +T D R+ L F A+ E++ Sbjct: 389 EQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDL 430 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 103 bits (258), Expect = 9e-21, Method: Composition-based stats. Identities = 71/418 (16%), Positives = 131/418 (31%), Gaps = 95/418 (22%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ +K I G + V L + Sbjct: 15 PVVELDG------DEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTL--DA 66 Query: 89 LDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPS 139 + I++Y V +K TP + S N +R L + P+ P Sbjct: 67 AEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPAIPR 125 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR--EEMGVKKIRFPEHCGIG 197 V + ++I R D Y + D+ +++ + + +K FP G+ Sbjct: 126 LVPSWKQP-IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKGGKPEVIKVYDFPAEGGVA 184 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 FKD ++ ++ E Sbjct: 185 QT----------------------------------------QFKDIFQEIYEAQYRKEF 204 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 G W + + D + Q++ Y +IA N +GD SD +A Sbjct: 205 EAAGIW-------------YEHRLIDDMVAQMIKSEGGY-IIAMKNYDGDVQSDIVAQGF 250 Query: 318 GGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGW 369 G +G+ I + F EA HGT ++ + + NP + I + L G Sbjct: 251 GSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQKGRETSTNPIASIYAWTQGLIKRGE 310 Query: 370 TE-------AADLIVKGMEGAI-NAKTVTYDF---ERLMDGAKLLKCSEFGDAIIENM 416 + A+ + K + +T D + D + + +E+ DA+ + Sbjct: 311 LDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQGKKDRSAWVTTNEYLDAVERRL 368 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 102 bits (253), Expect = 4e-20, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 8/122 (6%) Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSII 357 N+ GD +SD A G I +AP +I E +LFE HG+ P G+ NP + Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 358 L---SAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 M+L H+G+ E I +E +++ + D K + G AI Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGA--GNAPLTPDLGGSAKTDDLGKAIAA 118 Query: 415 NM 416 + Sbjct: 119 AI 120 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 97.8 bits (242), Expect = 7e-19, Method: Composition-based stats. Identities = 80/429 (18%), Positives = 142/429 (33%), Gaps = 89/429 (20%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 +NPI+ DG M +V+ +K + G + V Sbjct: 84 QNPIVEM---DG------DEMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDKVT 134 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV--- 131 + E+ + +Y VA+K TP + RS N +R L+ + P+ Sbjct: 135 V--ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCL 192 Query: 132 ---RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 R G P + I R D Y + K+I + ++ Sbjct: 193 NIPRIVPGWKKP--------ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLEL 244 Query: 189 RFPE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + G+ + + + + R +++ A A + + L K I+K +G FKD Sbjct: 245 DVYDFKGPGVALAMYNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIF 303 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 ++ E++ + + W + + D + + Y V AC N + Sbjct: 304 QEVYEEKWKQKFEEHSIW-------------YEHRLIDDMVAYAVKSEGGY-VWACKNYD 349 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKY-----AGQDKV-NPGSIILS 359 GD SD + EA HGT ++ GQ+ N + I + Sbjct: 350 GDLSSD------------------GKTLEAEAAHGTVTRHFRLFQKGQETSTNSIASIFA 391 Query: 360 AEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKL-----LKCSE 407 L H G + + + A +T D L+ G K+ L E Sbjct: 392 WTRGLEHRAKLDKNEGLLDFVHKLEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNTEE 451 Query: 408 FGDAIIENM 416 F DA+ +N+ Sbjct: 452 FIDAVAQNL 460 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 94.7 bits (234), Expect = 6e-18, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 127/423 (30%), Gaps = 75/423 (17%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 97 G ++T ++ ++ A + W E K+ V + ++ + + Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTA--WREFDLRAKNRDDTEDQVL--RDVIEAGKAVKA 73 Query: 98 AIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 K P TP ++ S N A+R+ + R + G K P + Sbjct: 74 IFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE 133 Query: 149 MVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 R YA G + + + + + Sbjct: 134 ----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNP 189 Query: 203 EEGTKRLVRAAIEYAIANDRDSVT--LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + L R + +T +V K + K+ E F ++ EE+ + +D Sbjct: 190 YDNVHELARFFFGRCLEA---KITPYVVTKKTVFKWQE-PFWQIMKKVFDEEYKSKFVDA 245 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 G + +++DA +++ +A N +GD ++D LA Sbjct: 246 GVMKSGD--------ELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSP 297 Query: 321 GIAPGANIG--DECAL---FEATHGTAPKY------AGQDKVNPGSII--LSAEMMLRHM 367 G +G + L FEA+HGT + +NP ++ L M Sbjct: 298 GFITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAM----- 352 Query: 368 GWTEAAD--------------LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 AAD + + T D G L +F DA+ Sbjct: 353 --NHAADVHNVDKERTLAFTAKMRAVIHQLFREGKGTRDLS----GPSGLTTEQFVDAVA 406 Query: 414 ENM 416 E + Sbjct: 407 ERL 409 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 93.2 bits (230), Expect = 2e-17, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 45/128 (35%), Gaps = 26/128 (20%) Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 2 LHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE---- 54 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 +K ++ + R+ A + A V VHK NI K Sbjct: 55 -------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLG 95 Query: 238 EGAFKDWG 245 +G F Sbjct: 96 DGPFLQCC 103 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 90.5 bits (223), Expect = 1e-16, Method: Composition-based stats. Identities = 65/429 (15%), Positives = 129/429 (30%), Gaps = 78/429 (18%) Query: 38 GVDVTP-AMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 G ++T A +++ +E + SW K+ + + ++ + Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS---SWETFDLSCKARDDSDDATLI--DAVEAGKRIG 143 Query: 97 VAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 K P TP ++ S N A+R+ + R + +G K+ L Sbjct: 144 AIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQVLF 203 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE--- 204 + R Y G W + + ++ ++ G + C Sbjct: 204 E----RHAVGGEY-GAGWNEV-GEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNP 257 Query: 205 --GTKRLVRAAIEYAIANDRDSVT--LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + L + + + VT +V K + K+ EG F ++ + + E + Sbjct: 258 YDNVRELAHLFFKRCLEH---KVTPYIVTKKTVFKWQEG-FWATMKRVFDDTYKDEFLKA 313 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 G + + +I+DA Q++ +A N +GD ++D +A Sbjct: 314 GLLDRSGG-------ELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSP 366 Query: 321 GIAPGANIG---DECAL---FEATHGTAPKYAGQDKV------NPGSII--LSAEM---- 362 G +G D L FEA+HGT NP ++ L M Sbjct: 367 GFITSNLVGVSDDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAA 426 Query: 363 ---------------MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 M ++ + + + T D G + Sbjct: 427 QLEYDAKPNDVEAKRMYEYV--NNFTNTLRMALHNTFRYGQGTRDMC----GPTGFTTED 480 Query: 408 FGDAIIENM 416 F + + Sbjct: 481 FIAKVAWRL 489 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 90.1 bits (222), Expect = 2e-16, Method: Composition-based stats. Identities = 31/134 (23%), Positives = 51/134 (38%), Gaps = 17/134 (12%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I GDGIG ++ ++ E + + ++ ST Sbjct: 50 RHTVTLIPGDGIGPEL-------LNHVRELFRFSCVPVDFEVVHVNSSSTSEDDIS---- 98 Query: 86 AETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + IR VA+KG + T + +S N LR LDLY + + G + K+ Sbjct: 99 -NAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKN 157 Query: 144 PELTDMVIFRENSE 157 D++I E SE Sbjct: 158 ---IDIIIILEKSE 168 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 89.3 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 42/310 (13%), Positives = 94/310 (30%), Gaps = 63/310 (20%) Query: 115 NVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEK 174 + LR+E+ Y +RP + + + P+ G+ A Sbjct: 47 LLKLRKEMGTYGSMRPCFFASDS---LVAPQGR--------------GVPRHRLCHCARA 89 Query: 175 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 234 ++L + + + +P S +R A + + N++ Sbjct: 90 HRRYL-----LWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVL 144 Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 T ++ + +EF ++ ++ + ++ + ++ P Sbjct: 145 -ATSRFWRKVMTETFEKEF-------------------PDLKVEHQLINSAVMIMVKNPT 184 Query: 295 EYD-VIACMNLNGDYISDALAAQVGGIGIAPGANIG-------DECALFEATHGTAPKYA 346 + V+ L GD ISDA IG+ P A++ ++E H Sbjct: 185 GLNGVVVTSTLFGDIISDAARVIPDSIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLV 242 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCS 406 + + + S W +D + ++ V R + Sbjct: 243 SRARASSTPSARSC-------PWPCFSDTL----STSLRRLWVPPWSLRTKELGGGANTK 291 Query: 407 EFGDAIIENM 416 E G+A+I + Sbjct: 292 ELGEAVINEV 301 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 88.2 bits (217), Expect = 6e-16, Method: Composition-based stats. Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 7/81 (8%) Query: 337 ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-NAKTVTYDFER 395 + HG+APKYAG KVNP +++LS MML+ + EAA I KG++ + AK +TYD Sbjct: 3 SVHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKHLTYD--- 59 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 E+ DAII+ M Sbjct: 60 ---AGGTASTDEYADAIIKAM 77 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 84.7 bits (208), Expect = 6e-15, Method: Composition-based stats. Identities = 70/409 (17%), Positives = 125/409 (30%), Gaps = 78/409 (19%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I G DG V A ++ + K I++ ++ ++ P Sbjct: 225 TVIAGYDG----VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANP---PERA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L P R L L ++L Y G P H Sbjct: 278 L-------------WGVPDNTTGRKL-YKLVKQLKRY----------GIPVRNAH----- 308 Query: 149 MVIFRENSEDIYAGIEWKA--DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ G ++ + A + ++K + + + R + I + E Sbjct: 309 VSISRMSAGG---GDQYGSFNMPAQEDGILKVVVDGVEKHARRVSQGDPILLMSNDHEAI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V A ++ V K M++ + F + RE + Sbjct: 366 KDWVSQVFRDA-SSKHKEVYFGLKREYMEY-DEVFSTVINDVRRELAADHTSPPAFMIMR 423 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + L +++ P + NL+GD SD AA G + A Sbjct: 424 PSSQ---------------LIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSI 468 Query: 327 NIGDECAL-FEATHGTAPKYA-------GQDK-VNPGSIILSAEMMLRHMGWTE------ 371 + FEA HGTA G+D NP ++I + L +G E Sbjct: 469 IESKSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALL 528 Query: 372 -AADLIVKGMEGAINAKTVTYDF---ERLMDGAKLLKCSEFGDAIIENM 416 + + ++ + VT D + L+ F D+I + + Sbjct: 529 DYSARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRL 577 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 79.7 bits (195), Expect = 2e-13, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 47/126 (37%), Gaps = 11/126 (8%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GD IG ++ LK + VE+ + ++ + S + + + LD Sbjct: 9 VLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYG--LLAGASLDKTNEP--ITDKVLD 64 Query: 91 LIREYRVAIKGPLTTPVGGGIRSLN------VALRQELDLYICLRPVRYYQGTPSPVKHP 144 + G + P + + LRQ LD + +RP R+ + + P Sbjct: 65 AALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSL-VEQSP 123 Query: 145 ELTDMV 150 +DMV Sbjct: 124 LKSDMV 129 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 78.2 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 39/117 (33%), Gaps = 15/117 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ KV+D K + I G S G V L E Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTK---YGHSFLYEAILMGGCSIDATG--VPLTDE 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRS----------LNVALRQELDLYICLRPVRYY 134 + + + G + + LR+ L+L+ LRP Y Sbjct: 59 AIAAAKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 77.8 bits (190), Expect = 7e-13, Method: Composition-based stats. Identities = 70/403 (17%), Positives = 131/403 (32%), Gaps = 80/403 (19%) Query: 34 GDGIGVDVTPAMLKVVDAAVEKAYKGERKI-----SWMEIYTGEKSTQVYGQDVWLPAET 88 G G G ++ +V+ K Y + ++ +T S + + ET Sbjct: 13 GHGTGRELVAVFERVIQTLA-KQYSVNFEFVRSSSTYHSYHTLTVSGEDKNLITHIADET 71 Query: 89 LDLIREY-----RVAIKGPLTTPVGGGIRSLNVAL-RQELDLYICLRPVRYYQGTPSPVK 142 +Y A G + I + ++ L RQ L + V+ Sbjct: 72 TKDAIDYQQFCENAAGSG-IAAIFRTAIHAQSLYLVRQHLQ--------------AAKVE 116 Query: 143 HPELTD---MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 H L D +++ R+ ++ YAG + Sbjct: 117 HFSLGDGNALLMVRDEAQGFYAGD----------------------NTYSADQLSITRTT 154 Query: 200 PCSEEGTKRLVRAAIEYAIAN-----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 S+ R++R A++ A N VT+ +K +G F+ W Q + +FG Sbjct: 155 SFSKPVFDRIIRFALDRAAENWGPENVPKKVTMAYK---FHLFDGVFQAWEPQ-WKAQFG 210 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 + P + + + +I +++P +N G S Sbjct: 211 IDFDFIQPDTLNR-SLMANGVQGRCIIIAGNEYADVIQP------VFLNWFGQ--STPET 261 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAA 373 + + P N + ++ HG+A A + VNP + I +A +L RH G Sbjct: 262 MYAENVYLRPDVN---GLSEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGIQ 318 Query: 374 DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L + ++ + K T D LK E D ++ + Sbjct: 319 KLTEQAIQSLLQRKLTTPDQ------GGSLKTEETVDHFLQAI 355 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 77.8 bits (190), Expect = 7e-13, Method: Composition-based stats. Identities = 63/404 (15%), Positives = 127/404 (31%), Gaps = 79/404 (19%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + G+G G ++T +V+ + + + IY S + ET Sbjct: 6 VGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADAVTEET 65 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVA-----LRQELDLYICLRPVRYYQGTPSPVKH 143 L YR K ++ V R+ A +R++L ++ T SP Sbjct: 66 LSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQA------IKVEHFTLSPTSS 119 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 +++ R+ ++ Y+G S DA + + Sbjct: 120 -----ILLVRDQAQGFYSGTNSVNTSKDAVSRTAHFSKAIFA------------------ 156 Query: 204 EGTKRLVRAAIEYAIA--NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 R++ A+ A +SVT+V+K +G F W + Sbjct: 157 ----RILSYALGRANQLWGGTNSVTMVYK---FHLFDGLFHTWATE------------WE 197 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 V + + +D++A + ++++ N D + L + G +G Sbjct: 198 RTFGVNIRFVQGDTMNRDLLAFGV--------SGHNLLISGNEYADIMQTILLDRFG-LG 248 Query: 322 IAPGANIGDEC--------ALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEA 372 A + + ++ HG+A G+ VNP + I +A +L G + Sbjct: 249 AQESACAENVYLHPDVQGLSEYQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQAGCSGL 308 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D F +A ++ + Sbjct: 309 KQRVDCVLGDLGARGIGTPDQ------GGTATTERFVEAFLQGL 346 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 75.5 bits (184), Expect = 4e-12, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 30/68 (44%) Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408 + NP ++ +A ML ++G A LI + T D + + + EF Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVGTKEF 65 Query: 409 GDAIIENM 416 +A+I+N+ Sbjct: 66 AEAVIDNL 73 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 74.3 bits (181), Expect = 8e-12, Method: Composition-based stats. Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Query: 335 FEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 +E G+AP AG++ NP + ILS M++R+ M +D I + + T D Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 394 ERLMDGAKLLKCSEFGDAI 412 D K ++ GD I Sbjct: 71 AN--DKEKCESTNDIGDII 87 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 74.3 bits (181), Expect = 9e-12, Method: Composition-based stats. Identities = 38/197 (19%), Positives = 70/197 (35%), Gaps = 22/197 (11%) Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ---ILLRPAEYDV 298 K+ + L RE + + L+++ + + +Q ++ P + + Sbjct: 381 KEVYFGLKREFVNYDEVYSSIILEIRKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGL 440 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKV------ 351 NL+GD SD AA G + A + LFEA HGTA + Sbjct: 441 YPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTLLFEAPHGTAHDLYLRYLETDGKEA 500 Query: 352 --NPGSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERL---MDG 399 N ++I + L + E A+ + + + T+T D + + Sbjct: 501 NFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIETVAQGTITGDLKGKTLAPES 560 Query: 400 AKLLKCSEFGDAIIENM 416 ++ F DAI N+ Sbjct: 561 ETVVDMYGFLDAIESNL 577 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 72.4 bits (176), Expect = 3e-11, Method: Composition-based stats. Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 3/75 (4%) Query: 339 HGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLM 397 G+AP AG++ NP + ILS M++R+ M + AD I + A+ T D + Sbjct: 1 GGSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVN 60 Query: 398 DGAKLLKCSEFGDAI 412 + + S+ GD I Sbjct: 61 E--THISTSDMGDVI 73 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 70.5 bits (171), Expect = 1e-10, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 36/90 (40%), Gaps = 5/90 (5%) Query: 16 LQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 ++ + I + GDG+G +V P + V+ A S+ E+ G + Sbjct: 30 IRCAANTPKKRYTIAVLPGDGVGNEVIPVAVDVLCLAGS---LEGIDFSFEELPIGGVAL 86 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTT 105 + G V LP ETL ++ + G + Sbjct: 87 DLVG--VPLPKETLIRAKQSDALLLGAVGW 114 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 70.5 bits (171), Expect = 1e-10, Method: Composition-based stats. Identities = 78/467 (16%), Positives = 134/467 (28%), Gaps = 132/467 (28%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 +NPI+ DG M +++ +K + G + V Sbjct: 64 QNPIVEM---DG------DEMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVT 114 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV--- 131 + E+ + +Y VA+K TP + RS N +R L+ + P+ Sbjct: 115 V--ESAEATLKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCX 172 Query: 132 ---RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 R G P + I R D Y + + K++ ++ Sbjct: 173 NVPRIVPGWKKP--------ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVEL 224 Query: 189 RFPE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + GI + + + + R +++ A A + + L K I+K +G Sbjct: 225 NVYDFKGPGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGR----- 278 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 + + D + L Y V AC N + Sbjct: 279 -------------------------------YEHRLIDDMVAYALKSDGGY-VWACKNYD 306 Query: 306 GDYISDALAA---------------------------------QVGG----IGIAPGANI 328 GD SD LA G I I+ Sbjct: 307 GDVQSDLLAQGFLLHMRNERSDYPVXLHLVKSYPILFVLSRIRFFGSYDFSIAISGKQLS 366 Query: 329 GDECAL-FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGWTEAADL------ 375 D L EA HGT ++ Q + N + I + L H + + Sbjct: 367 SDGKTLEAEAAHGTVTRHFRQYQKGLETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVH 426 Query: 376 -IVKGMEGAINAKTVTYDFERLMDGAKL-----LKCSEFGDAIIENM 416 + + + +T D L+ G K L EF D + N+ Sbjct: 427 KLEAACIETVESGNMTKDLAILIHGPKASXEFYLNTEEFIDTVAHNL 473 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 69.7 bits (169), Expect = 2e-10, Method: Composition-based stats. Identities = 65/396 (16%), Positives = 118/396 (29%), Gaps = 49/396 (12%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAV-EKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + I G G G ++ V + V E A + + ++ S Sbjct: 5 DPLRIGVAIGHGTGPELA----TVFEHVVRELASRYSLGVEFVRSDRIYHSYNSLPLADE 60 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSP 140 T D+ E I R L V R + LY +R + + Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYA-VR--QQLEAVKVE 117 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + +++ R+ ++ Y G D+ + R+ + I F Sbjct: 118 CFDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHFRKGVFQHIIAFSLERAREKWG 177 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 G SV LV+K +G W +EFG ++ Sbjct: 178 YDLGGI----------------KSVFLVYK---FHLFDGLLLSWARD-WTKEFGIKVEFI 217 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 P +N + +IA I+ I N + + + Sbjct: 218 QPDTMNRN-LIAFGVHRCLMIAGNEYADIMQ------TIFLEKFNMRVQETSCSE---NV 267 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 + P N + ++ THG+A G+ VNP + I +A +L G I + Sbjct: 268 YLKPVLN---RLSEYQTTHGSADDITGKGIVNPSATIRAAAAILERFG---GCVGIDAKV 321 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +N + + D L + F D + + Sbjct: 322 DDTLN--ILQKNKSGTPDQGGNLTTAAFVDVFLRTL 355 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 69.7 bits (169), Expect = 2e-10, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GD IG +V ++ V+ + E ++ + E+ G + G+ ++ Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILST--YRLEFTELDWGTARYKRTGK--YM 62 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQEL 122 PA+ L ++ + I G + P IR L+ +R+ Sbjct: 63 PADGLSTLKTFHAGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 67.8 bits (164), Expect = 8e-10, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 37/107 (34%), Gaps = 13/107 (12%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG+++T +KV+ A K +R S G + Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSAFSLK----KRTFDLRSELIDGCSIDTDGTPITKT 417 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLY 125 + + + + P G+R + LR+ ++ + Sbjct: 418 --VIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 67.8 bits (164), Expect = 8e-10, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 42/106 (39%), Gaps = 14/106 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 E I GDG+ ++ ++ V+ A I + I E + + Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI-------GAPIDFETILFSEV---QHSSSAKV 112 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYIC 127 + + I R+ + G L +P G +++L++ LR+ LDL Sbjct: 113 -EDVIKSINRNRICLMGALMSPDVSYSGELQNLHMKLRKGLDLIAN 157 Score = 66.2 bits (160), Expect = 2e-09, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 NP ++++ A MLRH+ ++ I + + A V R D EF Sbjct: 155 IANPTAMLMCASKMLRHVNLQHYSESIRNAIREVLAAGKV-----RTRDLGGSSSTHEFT 209 Query: 410 DAIIENM 416 DA+I+ + Sbjct: 210 DAVIKAI 216 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 65.8 bits (159), Expect = 3e-09, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 71/210 (33%), Gaps = 23/210 (10%) Query: 112 RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK-AD 168 RS N +R L+ + P + S K P + I R D Y + Sbjct: 32 RSPNGTIRNILNGTVFREPILCKNVPRILSGWKKP----ICIGRHAFGDQYRATDTIING 87 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTL 227 + V E + + G+ + + + + R +++ A++ + + L Sbjct: 88 PGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLYL 146 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 K I+K +G FKD ++ K K I + + D + Sbjct: 147 STKNTILKKYDGRFKDIFQEV-------------YEEKWKEKFEENSIWYEHRLIDDMVA 193 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQV 317 + Y V AC N +GD SD LA Sbjct: 194 YAVKSEGGY-VWACKNYDGDVQSDFLAQIF 222 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 65.8 bits (159), Expect = 3e-09, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 9/80 (11%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG +++ ++ K+ +AA I W + + +P++ Sbjct: 28 VTLIPGDGIGPEISSSVQKIFEAA-------NAPIEWDPVDV--TPVKGDDGIFRIPSKC 78 Query: 89 LDLIREYRVAIKGPLTTPVG 108 ++L+R ++ +KGPL TP Sbjct: 79 IELMRINKIGLKGPLATPNW 98 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 61.6 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 334 LFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADL 375 +FE HG+AP AG++ NP + I S ML RH G A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 61.6 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 33/84 (39%), Gaps = 4/84 (4%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG + P L+V DAA + + + + +G+ P Sbjct: 3 SYRIAVIPGDGIGKEAVPERLRVPDAAARR-FGFALHCGHFDF-ASSDTRARHGK--LRP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGG 109 + D +R Y G + P G Sbjct: 59 DDRFDTLRGYDALFFGAVGRPDTG 82 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 60.8 bits (146), Expect = 8e-08, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 11/81 (13%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG ++T ++ ++ + I W + S+ G+D++ Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV-------NAPIEWEQYNVSGMSSA--GEDLF--K 57 Query: 87 ETLDLIREYRVAIKGPLTTPV 107 + ++ +R RV +KG L TP+ Sbjct: 58 QAVESLRRNRVGLKGILFTPI 78 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 60.1 bits (144), Expect = 2e-07, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 46/143 (32%), Gaps = 28/143 (19%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + R A+ + + + + +LDLY+ R + G Sbjct: 104 DEYFHSVLRNRTAV--HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKCRF---P 158 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ I+ +E+ E + S++G Sbjct: 159 GVDIQLIGQNNMGIFNELEYSPVEGVVE-----------------------ALSVVSQKG 195 Query: 206 TKRLVRAAIEYAIANDRDSVTLV 228 + +R A + A R VTL+ Sbjct: 196 NDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 56.6 bits (135), Expect = 2e-06, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 32/80 (40%), Gaps = 4/80 (5%) Query: 337 ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERL 396 HG AP G NP +++++ +L G+ E A + +E A + Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVENQIESAFYENRD----QTT 264 Query: 397 MDGAKLLKCSEFGDAIIENM 416 D +L ++ ++E + Sbjct: 265 PDQGGVLNTEKYMAMMVECI 284 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 55.4 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 47/313 (15%), Positives = 98/313 (31%), Gaps = 73/313 (23%) Query: 27 PIIPYIEGDGIGVD---VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + ++GD + V L ++ ++V E+ G + + Sbjct: 2 YKLAILKGD---KESSSVIDRALGIIKSSV----NDSTAFEVTELPFGVNGVLSFNEP-- 52 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRP-VRYYQGTP 138 LP +TL ++ Y + G L VG ++ VALR+ Y+ + + Q + Sbjct: 53 LPNQTLRELKNYDGILVGALNQEVGTDSLLSVQESLVALRK----YLNITLACKAVQISD 108 Query: 139 -----SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 SP+K+ TD +I R V Sbjct: 109 NNVDASPLKNQIVRDTDFIIV-----------------------QSAKRANDHVDGNISV 145 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + + ++++ A E A+ N + +VT+V + +T + ++A+ Sbjct: 146 DDFAQDTITYEQREVEQVITAGFERAM-NRKRAVTVVTPFDSF-YTSKIWALTAEKIAK- 202 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 ++V+ V + I+ +P DV+ +++ Sbjct: 203 -------------------IYPDVVVNYVSLSCVISTIIQQPTSLDVVVAPKWVDQVLNE 243 Query: 312 ALAAQVGGIGIAP 324 G P Sbjct: 244 ESQKITGLPETVP 256 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 54.3 bits (129), Expect = 8e-06, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 83/219 (37%), Gaps = 34/219 (15%) Query: 162 GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND 221 G+E++++S + ++K E + PE +GI+ + + VR A+ D Sbjct: 116 GMEFESNSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLD 172 Query: 222 RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVI 281 D + + HKGN +K T+G F + +++ I + +I Sbjct: 173 VDDLVVAHKGNSIKHTDGLFALTAAE-----------------TLESLAGAAGIAWRSLI 215 Query: 282 ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG--IGIAPGANIGDECALFEATH 339 D +++ P +Y I + D ++ ALA Q+ +G+ + LF H Sbjct: 216 IDHMAAELVRNPLDYRAILTHSSFADLLAAALAGQMTTDQLGVCTTYDPAGR-PLFG--H 272 Query: 340 GTAPKYAGQDKVNP--------GSIILSAEMMLRHMGWT 370 A + D +P S + + + H+ Sbjct: 273 DPALDTSAPD-ADPERWRVRRLASTLAAGAALAEHLRLP 310 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 54.3 bits (129), Expect = 9e-06, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 22/51 (43%), Gaps = 3/51 (5%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 I + GDGIG ++ +KV++ A EK + G + +G Sbjct: 12 ILILPGDGIGPEIMTEAVKVLELANEK---YQLGFELTHDVIGGAAIDKHG 59 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 53.5 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 5/72 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA R +E G K ++Y V L E Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIE---GYKFNEMYLDTVCLNIE 62 Query: 88 T--LDLIREYRV 97 T I+ Sbjct: 63 TACFATIKCSDF 74 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 52.7 bits (125), Expect = 3e-05, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 25/52 (48%) Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MGW EA LI +E A + T D R M + L EFG+ I+ + Sbjct: 1 EYMGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYIMSVL 52 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.2 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 15/52 (28%), Positives = 22/52 (42%) Query: 224 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEI 275 VT +HK NIMK +G F +LA++ E + P+ I Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKDFPQLERRGSESGIDTDKPDVCFNI 130 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 50.8 bits (120), Expect = 9e-05, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 26/59 (44%), Gaps = 5/59 (8%) Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++L++ +ML H+ + A++I + +N + +D SE +I+ Sbjct: 1 MLLASCLMLDHLKLHDYANMIRSAILTTMNETRL-----HTVDIGGQGTTSEVVQSIMR 54 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 50.4 bits (119), Expect = 1e-04, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 34/105 (32%), Gaps = 29/105 (27%) Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + +G+ +GD LF + ++ NP + +L++ MML H+ Sbjct: 25 VGPELMAAVGVIECLKLGD--GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHL---- 78 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D C +F +A+I + Sbjct: 79 -----------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 47.7 bits (112), Expect = 7e-04, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 32/89 (35%), Gaps = 6/89 (6%) Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G LFE + ++KVNP +I S ++L G E A I + A Sbjct: 1 MGIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFGLQEEAGAIQMAVNSAGERG 58 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D C + GD + + Sbjct: 59 MYTTLDTLPKDIN----CDQLGDYLAAAI 83 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 47.7 bits (112), Expect = 8e-04, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 82/263 (31%), Gaps = 46/263 (17%) Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKP--CSEEGTKRLVRAAIEYAIAN---DRD 223 AD +++ E G G + S E T++L+ A+ A Sbjct: 146 DADGARLLLVRDEAQGFYTGGNTHTPGHVSRTTEFSREITEQLLAYALRRAREEWPEGPA 205 Query: 224 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIAD 283 + + +K +GA W A E + D Sbjct: 206 RIVMAYK---FHLLDGALDAWVRDFAARENIEVGVFQP---------------------D 241 Query: 284 AFLQQILLRP-AEYDVIACMNLNGDYISDALAAQVGGIGIAP---GANIGDECALFE--- 336 + ++ P + V+ N D + L + G G N+ + A+ E Sbjct: 242 TVNRNLVAHPPEDRTVLLAGNEWADIMHLVLLDRYGS-GRQEDHCTRNVHLDPAVAELVE 300 Query: 337 --ATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADLIVKGMEGAINAKTVTYDF 393 HG+A G+D +NP + + +A + R++G T A + A T D Sbjct: 301 YQTVHGSADDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGVRTPDQ 360 Query: 394 ERLMDGAKLLKCSEFGDAIIENM 416 + DA IE + Sbjct: 361 ------GGKHSTTGVVDAFIEEL 377 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 47.3 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 34/152 (22%), Positives = 60/152 (39%), Gaps = 29/152 (19%) Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 + HKGN +K+T+G F +A++E + D G I+ + +I D Sbjct: 1 MTHKGNSIKYTDGLFAV----VAKQELEKLIGDSG-------------IIQESLIIDHMA 43 Query: 287 QQILLRPAEYDVIACMN---------LNGDYISDALAAQVGGIGIAPGANIGDECALFEA 337 ++ P +Y I L+G +D IG A G + AL A Sbjct: 44 AELTRNPQDYRAILTHGAFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDPA 102 Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 H AP+ ++ S++L+ ++ H+ Sbjct: 103 RHTRAPEAEAAGRLR--SVLLAGSLLADHLDQ 132 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 45.8 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 18/28 (64%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEK 55 I + GDGIG ++ A L+V++A EK Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 45.0 bits (105), Expect = 0.005, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 20/44 (45%), Gaps = 7/44 (15%) Query: 30 PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEK 73 GDGIG ++ ++ +V AA + I W E + G + Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAA-------DVVIDWDEQFVGTE 83 >UniRef50_P41566 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3G_PIG Length = 106 Score = 42.3 bits (98), Expect = 0.035, Method: Composition-based stats. Identities = 7/21 (33%), Positives = 14/21 (66%) Query: 348 QDKVNPGSIILSAEMMLRHMG 368 ++ NP + +L++ MML H+ Sbjct: 86 KNIANPTATLLASCMMLDHLK 106 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 41.6 bits (96), Expect = 0.058, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 18/50 (36%), Gaps = 3/50 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 I + GDGIG ++ L+V++A EK G Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKT---GFDYEIDRRPFGGADIDA 50 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 465 e-129 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 454 e-126 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 440 e-122 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 436 e-120 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 427 e-118 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 419 e-116 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 418 e-115 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 417 e-115 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 415 e-114 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 415 e-114 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 409 e-113 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 407 e-112 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 402 e-110 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 402 e-110 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 394 e-108 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 391 e-107 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 386 e-106 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 383 e-105 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 381 e-104 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 380 e-104 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 380 e-104 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 373 e-102 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 372 e-101 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 366 e-100 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 365 2e-99 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 364 3e-99 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 364 4e-99 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 364 4e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 362 2e-98 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 361 2e-98 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 360 5e-98 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 360 8e-98 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 359 9e-98 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 357 3e-97 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 356 1e-96 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 356 1e-96 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 355 2e-96 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 352 1e-95 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 352 1e-95 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 352 2e-95 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 352 2e-95 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 351 3e-95 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 349 1e-94 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 349 1e-94 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 348 2e-94 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 348 2e-94 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 348 2e-94 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 348 3e-94 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 344 3e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 344 4e-93 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 342 2e-92 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 340 5e-92 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 340 6e-92 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 340 7e-92 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 338 2e-91 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 338 2e-91 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 338 2e-91 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 338 2e-91 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 338 3e-91 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 337 6e-91 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 337 6e-91 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 336 8e-91 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 336 1e-90 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 334 4e-90 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 333 5e-90 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 333 6e-90 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 333 6e-90 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 333 7e-90 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 332 2e-89 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 332 2e-89 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 332 2e-89 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 330 5e-89 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 330 7e-89 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 330 7e-89 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 330 7e-89 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 328 2e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 328 2e-88 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 328 2e-88 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 328 2e-88 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 328 2e-88 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 328 3e-88 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 327 4e-88 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 327 4e-88 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 326 9e-88 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 326 1e-87 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 325 2e-87 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 324 3e-87 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 323 6e-87 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 323 1e-86 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 321 2e-86 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 320 5e-86 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 318 2e-85 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 318 2e-85 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 318 3e-85 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 317 5e-85 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 316 9e-85 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 316 1e-84 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 315 1e-84 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 315 2e-84 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 314 5e-84 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 313 7e-84 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 312 2e-83 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 312 2e-83 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 311 2e-83 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 311 2e-83 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 311 3e-83 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 311 3e-83 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 310 5e-83 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 310 6e-83 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 309 1e-82 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 309 1e-82 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 306 8e-82 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 305 2e-81 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 305 2e-81 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 305 3e-81 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 305 3e-81 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 303 1e-80 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 303 1e-80 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 301 3e-80 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 300 6e-80 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 300 7e-80 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 299 1e-79 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 299 2e-79 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 299 2e-79 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 296 7e-79 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 295 2e-78 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 291 2e-77 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 291 4e-77 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 288 2e-76 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 286 8e-76 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 284 5e-75 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 283 7e-75 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 281 3e-74 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 280 7e-74 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 280 9e-74 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 279 1e-73 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 276 1e-72 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 272 2e-71 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 268 3e-70 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 268 4e-70 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 267 4e-70 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 266 1e-69 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 263 9e-69 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 259 1e-67 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 258 2e-67 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 258 2e-67 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 257 6e-67 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 256 1e-66 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 252 1e-65 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 252 2e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 248 3e-64 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 245 3e-63 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 244 5e-63 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 243 9e-63 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 240 5e-62 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 240 9e-62 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 234 4e-60 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 228 3e-58 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 225 2e-57 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 224 4e-57 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 221 3e-56 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 219 2e-55 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 218 4e-55 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 216 2e-54 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 214 4e-54 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 211 5e-53 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 211 6e-53 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 205 2e-51 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 204 4e-51 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 199 1e-49 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 199 2e-49 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 192 2e-47 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 191 4e-47 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 190 1e-46 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 187 9e-46 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 184 5e-45 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 177 5e-43 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 173 1e-41 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 172 3e-41 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 169 2e-40 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 169 2e-40 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 167 1e-39 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 157 5e-37 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 157 7e-37 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 152 2e-35 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 146 2e-33 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 145 2e-33 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 143 9e-33 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 136 1e-30 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 135 4e-30 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 120 1e-25 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 119 3e-25 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 114 6e-24 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 114 1e-23 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 113 1e-23 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 102 2e-20 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 100 2e-19 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 89 4e-16 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 89 4e-16 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 88 8e-16 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 87 1e-15 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 86 3e-15 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 82 5e-14 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 82 5e-14 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 78 5e-13 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 78 5e-13 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 77 1e-12 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 75 3e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 75 6e-12 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 75 6e-12 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 75 6e-12 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 72 5e-11 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 67 1e-09 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 65 5e-09 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 64 9e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 64 1e-08 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 63 2e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 61 6e-08 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 59 3e-07 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 59 4e-07 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 58 7e-07 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 55 3e-06 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 55 5e-06 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 6e-05 Sequences not found previously or not previously below threshold: UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 50 1e-04 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 49 5e-04 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 48 6e-04 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 48 7e-04 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 47 0.001 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 47 0.001 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 47 0.001 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 46 0.002 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 44 0.007 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 42 0.034 UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyalop... 42 0.040 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 327/416 (78%), Positives = 370/416 (88%), Gaps = 1/416 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + L+VP+NPIIP+IEGDGIGVD++P M+KVVDAAVEKAYKGE Sbjct: 3 YQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+C RPVR+++G PSPVK P DMVIFRENSEDIYAG+EWKA S +AEKVIKFL Sbjct: 123 QLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLT 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++YA+ NDR SVTLVHKGNIMKFTEGA Sbjct: 183 EEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGA 242 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY++AR+EFG EL+DGGPW++ KNP TGK +V+KDVIADA LQQILLRPAEYDVIA Sbjct: 243 FKDWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIA 302 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAA+VGGIGIAPGAN+ D A+FEATHGTAPKYAGQDKVNPGS+ILSA Sbjct: 303 TLNLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSA 362 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGWTEAADLI+KG GAI AKTVTYDFERLMDGA LL CSEFGDA+I M Sbjct: 363 EMMLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 307/416 (73%), Positives = 360/416 (86%), Gaps = 1/416 (0%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+ Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 +NLNGDY+SDALAAQVGGIGIAPGAN+GDE A+FEATHGTAPKYAG++KVNPGS+ILSA Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 440 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 291/419 (69%), Positives = 346/419 (82%), Gaps = 8/419 (1%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+ Sbjct: 8 LQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query: 65 WMEIYTGEKSTQVYGQD-------VWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA 117 W E++ GEK Q + WL +T++ I Y+V+IKGPLTTP+G G RSLNVA Sbjct: 68 WYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query: 118 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 177 LRQ++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I Sbjct: 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query: 178 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 237 FL+ E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+T Sbjct: 187 FLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query: 238 EGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD 297 EGAF WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY Sbjct: 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYS 306 Query: 298 VIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSII 357 VIA MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSII Sbjct: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LSAEMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM Sbjct: 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 436 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 221/422 (52%), Positives = 291/422 (68%), Gaps = 10/422 (2%) Query: 2 ESKVVVPAQGKKITLQNGK---LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 K+ VP G+KITL+ G + VP+NPIIP I GDGIG DV PA KV++AA E Sbjct: 3 YDKIEVPDAGEKITLKEGSEDEIEVPDNPIIPIIHGDGIGKDVGPAAQKVLEAAAE---A 59 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R ISWM +Y GE + + YG+DV LP ET+D IRE+RVAIKGPLTTPVG G RSLNVAL Sbjct: 60 TGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LDLY +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + +EMG + GIG+KP +E+G+KRLVR AI+YA+ +DRD VTLVHKGNIMKFTE Sbjct: 180 VEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F DWG ++A EE+ + + P W + ++ +++++ +ADA LQ + LR Sbjct: 240 GQFGDWGMEVADEEYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+D++A NLNGDY+SDA AQ+GG+GIAPG N G L E HG+APK AGQD NP Sbjct: 300 EFDILAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGKGRMLAEPVHGSAPKRAGQDMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M ++GW +AADLI +E I++ VTYD ER ++ A+ L SE+ D I++ Sbjct: 360 AMILSGRLMFDYLGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVD 419 Query: 415 NM 416 + Sbjct: 420 TI 421 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 427 bits (1098), Expect = e-118, Method: Composition-based stats. Identities = 261/422 (61%), Positives = 314/422 (74%), Gaps = 17/422 (4%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 +KIT LNVP PIIP+I GDGIG D+ A +V+DAAVEKAY GE++I W E+ Sbjct: 2 TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVL 61 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 G+K+ G+ WLP ETLD I+EY +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLR Sbjct: 62 AGQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLR 119 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 PVR+++G PSPVK P+ DMVIFREN+EDIYAGIE+K + + +KVI FL+ EMG IR Sbjct: 120 PVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIR 179 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 FPE GIGIKP S+EGT+RLVRAAI+YAI N+R SVTLVHKGNIMKFTEG+FK WGY LA Sbjct: 180 FPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239 Query: 250 REEFGGELIDGGPWLK-------------VKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 EFG ++ + + + +I+IKD IAD FLQQIL RPAE+ Sbjct: 240 LTEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEH 299 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE--CALFEATHGTAPKYAGQDKVNPG 354 DV+A MNLNGDYISDALAAQVGGIGIAPGANI E A+FEATHGTAPKYAG +KVNP Sbjct: 300 DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPS 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 S+ILS+ +ML H+GW EAAD I +E I +K VTYDF RLMDGA+ + S F D +I+ Sbjct: 360 SVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIK 419 Query: 415 NM 416 N+ Sbjct: 420 NL 421 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 419 bits (1078), Expect = e-116, Method: Composition-based stats. Identities = 206/415 (49%), Positives = 295/415 (71%), Gaps = 3/415 (0%) Query: 2 ESKVVVPAQGKKITL-QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 + VP QG+ I + +NG+ +P PII YI+GDG+G DV P M KVVD+A+ Y+ + Sbjct: 6 YQHINVPEQGQSIKIAKNGQWQIPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAK 65 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKI WM++Y GE++ ++Y W P ET++ +RE ++AIKGPLTTP+GGG RSLNVALRQ Sbjct: 66 RKIHWMQVYNGEQAAKLY-DGDWFPQETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQ 124 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 E+DL++ +R ++ + PSP+K+P LT++ + R++SED+Y+GIEW+A S ++EKV+ FL Sbjct: 125 EMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLC 184 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 EEMGV ++RF + CGIGIK S+EG++RLVR AI YA+ N+ +S+TLVHKGN++KFT+GA Sbjct: 185 EEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGA 244 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK WG+ LA+ E+ + G WL + ++IK+VIAD LQQ L+ P ++DV+A Sbjct: 245 FKRWGFALAKREYQAIDDENGRWLHIPR-QGQPPLIIKEVIADNMLQQCLMHPEQFDVVA 303 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 N NGD+++D L+AQVGG+GI P AN+ +E A FE THGT + AGQ+K NP S ILSA Sbjct: 304 TTNQNGDFLADMLSAQVGGVGIMPAANLNNEVAFFEPTHGTFARIAGQNKANPSSSILSA 363 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 +ML+ M W EAA+LI +E + A VT+D + L C++F +IE+ Sbjct: 364 VLMLKFMQWHEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 235/471 (49%), Positives = 304/471 (64%), Gaps = 56/471 (11%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G+KIT QNG+ VP+NPI+P+I GDG G+D+ PA KV+DAAV KAY G+ Sbjct: 1 MYEKITPPSTGEKITFQNGEPIVPDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGK 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISW ++Y G+++ +YG +LP +TL I+EY +AIKGPLTTP+GGGIRSLNVALRQ Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K P+ D++++REN+EDIY GIEWK S E++I L Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 ++ K + P GIGIKP S G++RLVR A+++A+ ++ VTLVHKGNI Sbjct: 181 KDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MK+TEGAF+DWGY+LA +EF E + Sbjct: 241 MKYTEGAFRDWGYELATQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTP 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W + ++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKKAQIVKEVETVINSIWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD CA+FEATHGTAPK+AG DK+NPGS+ILS MML Sbjct: 361 GDYLSDAAAAIVGGLGMGPGANIGDSCAIFEATHGTAPKHAGLDKINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA-KLLKCSEFGDAIIEN 415 +MGW EAADLI +G+ +I VTYD RLM+ + LKCSEF D II+ Sbjct: 421 YMGWQEAADLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 417 bits (1072), Expect = e-115, Method: Composition-based stats. Identities = 196/423 (46%), Positives = 274/423 (64%), Gaps = 13/423 (3%) Query: 2 ESKVVVPAQGKKITLQN-GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K + P G+ + G+L VP+ +I YIEGDGIG +V A +KV + AVEKAY Sbjct: 19 TGKYIDPPSGEYVKYTGPGQLKVPDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKS 78 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 R+I+W EI GEK+ +++G LP ++++++R+ RV +K PL TPVGGG RS+NV LRQ Sbjct: 79 RQITWYEIVVGEKAEKLFGN--RLPDQSIEVLRKIRVFLKAPLETPVGGGFRSINVTLRQ 136 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ED+YAGIEW +S +A K+ +FLR Sbjct: 137 LFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLR 196 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 E GV + GIGIKP S+ GT+R+ R A+++AI N R VT++HKGNI K+TEGA Sbjct: 197 REFGV---NIRDDAGIGIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGA 253 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 FK+W +++AR EF ++ + ++++ D IAD LQQ+L R EYDVI Sbjct: 254 FKEWAFEVARNEFREHVVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVIL 313 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A VGG+G+APG ++GD + E HGTAPKY G++ VNP + IL+ Sbjct: 314 APNLNGDYVSDEAAGLVGGLGVAPGLDVGDWGMMAEPVHGTAPKYRGKNYVNPTATILAL 373 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERL-------MDGAKLLKCSEFGDAII 413 E+M R +GW E A+ I+KG+E A T D R M ++L EF D ++ Sbjct: 374 ELMFRFLGWREVAEYIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVV 433 Query: 414 ENM 416 E + Sbjct: 434 EII 436 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 196/416 (47%), Positives = 263/416 (63%), Gaps = 8/416 (1%) Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62 + P++G+ +NGKL VP+N I+ Y +GDGIG ++ + KV+DAAV+KAY G R+ Sbjct: 9 DEAKPPSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRR 68 Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122 I W E+ GE++ + G LP TL + RV +KGPLTTPVGGG RSLNV LR L Sbjct: 69 IVWWEVTAGEEAQKECG--SLLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVL 126 Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 DLY +RPV++Y G P+P HPE D VIFREN+ED+YAGIEW DS +A+K+ FL++E Sbjct: 127 DLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKE 185 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 G I GIGIKP S+ T+R VR A+E+AI N VT++HKGNIMK+TEGAF+ Sbjct: 186 FG---IELTPDTGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFR 242 Query: 243 DWGYQLAREEFGGELIDGGPWLK-VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 W Y L EF ++ +I++ D IAD LQQI+ RP EY+VI Sbjct: 243 QWAYDLILSEFRDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVT 302 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 NLNGDYISD A VGGIG+A G ++GD A+ E HG+APKYAG++ +NP + ILS Sbjct: 303 PNLNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSGM 362 Query: 362 MML-RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +L +GW E L+ ++ AI K VTYD R M G + +E+ D +++ + Sbjct: 363 YLLSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 216/422 (51%), Positives = 289/422 (68%), Gaps = 12/422 (2%) Query: 2 ESKVVVPAQGKKITL---QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYK 58 KV VPA+G+KI + N +L++PENPI+P I GDGIG DV PA KV++AA Sbjct: 5 YDKVEVPAEGEKIEVVDEDNDELDIPENPIVPIIHGDGIGKDVGPAAQKVLEAAA---NA 61 Query: 59 GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 R+ISWM ++ GE + + Y ++ LP +T++ I E+RVAIKGPLTTPVG G RSLNVAL Sbjct: 62 TGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHRVAIKGPLTTPVGAGFRSLNVAL 119 Query: 119 RQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKF 178 RQ LD Y +RP Y G PSP+K PE DMV FREN+ED+YAGIEW+A + + E+V +F Sbjct: 120 RQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREF 179 Query: 179 LREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTE 238 + E+MG + GIGIKP +E G+KRLVR AI+YAI +DRD VTLV KGNIMKFTE Sbjct: 180 VEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTE 239 Query: 239 GAFKDWGYQLAREEFGGELIDGGP---WLKVKNPNTGKE-IVIKDVIADAFLQQILLRPA 294 G F +WG ++A EE+ + + P W + ++ ++++ +ADA LQ + LR Sbjct: 240 GQFTEWGMEVADEEYPDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTD 299 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 E+ V+A NLNGDY+SDA AQ+GG+GIAPGAN GD L E HG+APK AGQ+ NP Sbjct: 300 EFSVLAMPNLNGDYLSDAAGAQIGGLGIAPGANFGDARVLAEPVHGSAPKRAGQNMANPT 359 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 ++ILS +M +MGW +AADL+ +E I++ TVTYD ER ++ A+ L E+ DAI+E Sbjct: 360 AMILSGRLMFDYMGWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVE 419 Query: 415 NM 416 N+ Sbjct: 420 NI 421 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 409 bits (1051), Expect = e-113, Method: Composition-based stats. Identities = 186/420 (44%), Positives = 264/420 (62%), Gaps = 12/420 (2%) Query: 2 ESKVVVPAQGKKITLQNGK-LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 E K +P +G+ I L+ K L VP+NPIIP+IEGDGIG ++T AML +++ AVEK Y G Sbjct: 13 EGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGS 72 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +KI W+E+ G+K+ + G+ LP ETLD+++E V IKGPL TPVG G+RS+N ALR+ Sbjct: 73 KKIYWVELLAGDKAEEKTGE--RLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRR 130 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 D Y +RPV Y+ G +P+ +PE D+V+FREN++D+YAG+E+ A + +A+KV +FL Sbjct: 131 AFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLI 189 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 +EMG K+ FPE GI +KP SE TKR VR A+ YA+ N++ +V ++ KGNIMK TEGA Sbjct: 190 KEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGA 249 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F +W +++A E G + ++ + VI D L Q++L+P +DVI Sbjct: 250 FINWAFEVAEE----PEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVII 305 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGDY+SD A+ +GG G P NIGD ALFE+THGTA AG+ NP S+ LS Sbjct: 306 AQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSG 365 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFE----RLMDGAKLLKCSEFGDAIIENM 416 MML ++GW EAA + + + T D + AK + EF + I + + Sbjct: 366 AMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 212/419 (50%), Positives = 284/419 (67%), Gaps = 17/419 (4%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 +K+T+ NG+L VP NP IP+IEGDGIG ++ A V DAAV+KAY G+++++W+ + G Sbjct: 4 EKVTMNNGQLQVPNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAG 63 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131 E + + GQ WLP +TL +REY V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV Sbjct: 64 ETAYKKTGQ--WLPDKTLATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPV 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 YY GTPSPV HPE ++ +FREN+EDIYAGIE D+ DAE+ L ++ + K+RFP Sbjct: 122 TYYPGTPSPVVHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFP 181 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + IKP S++G+ RLV AAI+YA AN+R ++TLVHKGNIMK TEG FK WGY+ A + Sbjct: 182 DTSAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEK 241 Query: 252 E------------FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVI 299 + + + +++++ DVI D F QQ LL P ++V+ Sbjct: 242 YGDKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVV 301 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGD--ECALFEATHGTAPKYAGQDKVNPGSII 357 A MNLNGDYISDALAAQVGGIGIAPG NI A+FEATHGTAP++AGQ+K+NP SII Sbjct: 302 ATMNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSII 361 Query: 358 LSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LS MM ++GW + ++LI G++ AI + VT DF + D A +L S FG+ + + + Sbjct: 362 LSGAMMFDYLGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPD-ATVLSTSGFGEYVAQLI 419 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 233/472 (49%), Positives = 293/472 (62%), Gaps = 57/472 (12%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 +I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180 Query: 181 EE-----MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS--VTLVHKGNI 233 +E + K + GIGIKP S+ G++RLVR AI +A + VTLVHKGNI Sbjct: 181 DELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNI 240 Query: 234 MKFTEGAFKDWGYQLAREEFGGELID---------------------------------- 259 MKFTEG F+DWGY+LA EF E + Sbjct: 241 MKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTE 300 Query: 260 --------------GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 W N +++++ D IAD+ QQI RP EY ++A MNLN Sbjct: 301 EKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLN 360 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GDY+SDA AA VGG+G+ PGANIGD A+FEATHGTAPK+AG D++NPGS+ILS MML Sbjct: 361 GDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLE 420 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIEN 415 MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ + Sbjct: 421 FMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 402 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 161/391 (41%), Positives = 221/391 (56%), Gaps = 40/391 (10%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +VT AM V++A + W+ + G + + YG LP Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA-------SGVDLEWIRVEAGVEVIEKYGTP--LPP 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + L+ IRE RVAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + Sbjct: 54 QVLESIRETRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QD 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + +A + + G E IGIKP SE G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGS 167 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+V+ A EYA N R VT VHK NIMKFT+G F ++A+E Sbjct: 168 RRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY-------------- 213 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I +D+I D Q++ +P YDV+ NL GD ISD A +GG+G+APGA Sbjct: 214 ------PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGA 267 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIGD A+FEA HG+APKYAGQ+KVNP ++ILS MMLR++G EAA + ++ I Sbjct: 268 NIGDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAE 327 Query: 387 K-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VTYD + + + E +AI + Sbjct: 328 GKYVTYDLAQ----GEPVGTQEMAEAIAARV 354 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 394 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 118/391 (30%), Positives = 187/391 (47%), Gaps = 60/391 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG +VT A ++V++A K W G ++ + Y + ++P Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIP 52 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + I R+ +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + Sbjct: 53 KELNESIERTRIGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---P 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+V+ REN+E +Y+GIE + E +K +E+ Sbjct: 110 GVDLVVVRENTEGLYSGIEHEVVPGVVE-----------------------SLKIITEKA 146 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R+ + A YA R + +HK NIMK ++G F +++E Sbjct: 147 STRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY------------- 193 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 EI+ + I D Q+++ P +YD++ NL GD +SD A VGG+G+APG Sbjct: 194 -------PEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPG 246 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIG+ ++FEA HG+AP AG++ NP ++I S +MLRH+ +AA+ + + Sbjct: 247 ANIGERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRHLDEQDAANRVKAAVHHVYR 306 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D SEF D ++E + Sbjct: 307 EGKH-----LTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 391 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 67/405 (16%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 TL+N + + + I GDGIG +++ ++ +V A I W + Sbjct: 10 FSTLRNYSSSTSKIQKVTLIPGDGIGPEISESVKRVFSAVKA-------PIEWETVVVDA 62 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 63 N--------TGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCL 114 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G + + V+ REN+E Y+GIE + Sbjct: 115 SIPGHKTRY---NNVNTVVVRENTEGEYSGIENQPVKG---------------------- 149 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F +++ Sbjct: 150 -VAQSIKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY 208 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 I +++ D Q++L P + DV+ NL GD +SD Sbjct: 209 --------------------PSIKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDL 248 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 A +GG+G+ P NIG+ A+FEA HGTAP AG++K NP ++ILS+ MMLRH+G Sbjct: 249 CAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFH 308 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + + V + D CSE+ D +++ + Sbjct: 309 EASIIENAVLNTLTEGKV-----KTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 124/398 (31%), Positives = 189/398 (47%), Gaps = 62/398 (15%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + I GDGIG +++ A+ ++ + I W + + T+ Sbjct: 1970 KSSSTTIKTVALIPGDGIGPEISAAVQEIFK-------FADVPIKWESVDVTPRPTE--D 2020 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P +LD+IR++ + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G + Sbjct: 2021 GRFRMPQSSLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYET 2080 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 P K D+V REN+E Y+GIE + IK Sbjct: 2081 PYK---NVDLVTVRENTEGEYSGIEHVIVDGVVQ-----------------------SIK 2114 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +EE ++R+ R A +YA N R SVT VHK NIM+ ++G F + A Sbjct: 2115 LITEEASRRVARFAFQYAKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAH-------- 2166 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +EI D+ D ++ P +DV+ NL GD +SD A +GG Sbjct: 2167 ------------HREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNLYGDILSDLAAGLIGG 2214 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 +G+ P NIG+ A+FE+ HGTAP AGQD+ NP +++ SA MMLR+M + ADLI Sbjct: 2215 LGVTPSGNIGETGAIFESVHGTAPDIAGQDRANPTALLFSAIMMLRYMNLNKHADLIESA 2274 Query: 380 MEGAINA-KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I K +T D CS++ I + Sbjct: 2275 VLATIREAKYLTADL------GGRSTCSQYTKEICRQI 2306 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 122/395 (30%), Positives = 180/395 (45%), Gaps = 55/395 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + GDGIG ++ A++ V+ A + I GEK Y Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA-------VPLRLETIEIGEKLYNKY-YTY 52 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV 141 + +T I + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + Sbjct: 53 GITEDTWSQIFRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNT-- 110 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 D+VI REN ED+YAGIE+ +K Sbjct: 111 -SAPEIDVVIIRENEEDLYAGIEYH-----------------------HTADTYESVKLI 146 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 S G+++++R A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 147 SRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYS-------- 198 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + D +++ P ++DVI NL GD +SD A G IG Sbjct: 199 ------------NIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIG 246 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 +A ANIG + A+FEA HG+AP AGQ+ NP ++ +A MML H+G TE A I ++ Sbjct: 247 LAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALK 306 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I T D + + EF AII N+ Sbjct: 307 KTIEDGIHTADIYNPSISSTKVGTKEFAQAIINNL 341 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 119/390 (30%), Positives = 180/390 (46%), Gaps = 61/390 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA I W E + Q G +P+E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA-------PIQWEERNV--TAIQGPGGKWMIPSE 83 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + + ++ +KGPL TP+ G S+N+ LR+ DLY +RP +G +P Sbjct: 84 AKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DV 140 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++V REN+E Y+GIE + IK +E +K Sbjct: 141 NIVTIRENTEGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASK 177 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A EYA N R +VT VHK NIM+ ++G F ++A Sbjct: 178 RIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE----------------- 220 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + K+I ++ D ++ P+++DV+ NL GD +SD A +GG+G+ P N Sbjct: 221 ---SCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGN 277 Query: 328 IGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG A+FE+ HGTAP AG+D NP +++LSA MMLRHMG + A I I Sbjct: 278 IGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKD 337 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 D KCS+F + I + Sbjct: 338 GK-----SLTKDLGGNAKCSDFTEEICRRV 362 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 109/389 (28%), Positives = 169/389 (43%), Gaps = 66/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V A + +++ + + G+++ + YG+ LP E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL-------DLPFEYSYYDAGDEALEKYGK--ALPDE 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 TL+ R+ + G + V LR+EL + +RP + +G Sbjct: 54 TLEACRKSDAVLFGAAG----ETAADVIVRLRRELGTFANVRPAKAIEGIECLY---PGL 106 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E +Y G E+ I+ + E ++ Sbjct: 107 DIVVVRENTECLYMGFEFGFG------------------------DVTEAIRVITREASE 142 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A E A R VT +HK N+MK T G F+D ++A++ Sbjct: 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY--------------- 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 EI D DA +++ P +DVI N+ GD +SD A VGG+G+AP AN Sbjct: 188 -----PEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G+ A+FE HG A AG+ NP ++IL+A MMLRH G+ E A + + +E I Sbjct: 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D LK EF + + + Sbjct: 303 KKTPDL------GGNLKTMEFANEVASLL 325 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 107/408 (26%), Positives = 174/408 (42%), Gaps = 60/408 (14%) Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68 A + T K + +N + G GIG +++ A+ + AA + I W Sbjct: 287 AMIPRYTFSQKKKSQKQNHKVVLFPGHGIGPEISQAVCDIFAAA-------KVPIDWEHH 339 Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128 K G + E+L+ + Y+ +KGP TP+G G RSLNV +R++L+L+ + Sbjct: 340 EIYTKPINEAGD--LIKEESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANV 397 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RP R G +P D+V REN+E Y+G+E E Sbjct: 398 RPCRSLAGVKTPYS---NVDLVTIRENTEGEYSGLEHAVVPGVVE--------------- 439 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S+ + + R A E+A N+R V HK +MK +G F + ++ Sbjct: 440 --------NLKIISQPACENIARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKI 491 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 + E EI + D ++ P +DV+ NL GD Sbjct: 492 SSEY--------------------PEIEYTEEQIDTVCMKLSKNPEVFDVMVMPNLYGDI 531 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A +GG+G+ NI CA++EA HGTAP AG +K NP +++LS MML+ MG Sbjct: 532 VSDLCAGLIGGLGLTASGNISHTCAVYEAVHGTAPDIAGLNKANPTALLLSGVMMLKAMG 591 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I + + ++ D +++ A+I ++ Sbjct: 592 LQKEGFAIEEAVIKTLSEGK-----FLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 373 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 131/417 (31%), Positives = 197/417 (47%), Gaps = 62/417 (14%) Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 ME A K + NGK + I GDGIG ++ + ++++A Sbjct: 1 MEQSGGSGATMKYVVTPNGKKL------VTLIPGDGIGPEIVESACRLIEAV-------G 47 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 I W G + G +P +T++ I+ RV +KGPL TPVG G +S NV LR+ Sbjct: 48 APIEWEVRRAGASVFRE-GIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRK 106 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 + + +RPVR P+P + D+V+ REN ED+YA IE++ Sbjct: 107 LFEAFANVRPVRELPSVPTPYRG-RNIDLVVVRENIEDLYAAIEYRETPGVT-------- 157 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 I K S +G+++++R A E A A R VT K NI+K TEG Sbjct: 158 ---------------IAHKLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGW 202 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 F+ ++A E +I +I D Q++ P +++VI Sbjct: 203 FQHIFEEIASEY--------------------PDIEANHLIIDNCAHQLVKAPEQFEVIV 242 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360 NLNGD ISD + VGG+G A N G E A+FE HGTAPKYAG++ +NP ++IL+A Sbjct: 243 TTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTA 302 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 MMLR++ E A+ I + + + +T D + + + + F DAII N+ Sbjct: 303 VMMLRYIDEFETAETIEQALIVTLEEGKALTRDV---VGDERAVSTTAFTDAIIANL 356 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 372 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 115/400 (28%), Positives = 188/400 (47%), Gaps = 63/400 (15%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 G+ + IEGDGIG +++ ++ + AA I W + + + Sbjct: 47 GQKGADGKYTVTLIEGDGIGPEISQSVKDIFSAA-------NAPIKWEPVDV---TPILK 96 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 +P + ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G Sbjct: 97 DGKTAIPDDAIESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYK 156 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 +P + D V+ REN+E Y+GIE + I Sbjct: 157 TPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQ-----------------------SI 190 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K ++E ++R++R A +YA + ++ V +VHK IMK ++G F + ++A++ Sbjct: 191 KLITKEASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDF------ 244 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQ 316 ++ + D +I+ P Y+ V+ NL GD +SD A Sbjct: 245 --------------PDVEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGL 290 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GG+G+ P NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A I Sbjct: 291 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAGRI 350 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D K SE+ +AI++ + Sbjct: 351 QKAIFDTLAEGK-----ALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 139/405 (34%), Positives = 203/405 (50%), Gaps = 58/405 (14%) Query: 15 TLQNGKLNVPE--NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 T K++V E +I I GDGIG + A LKV++AA +++ G Sbjct: 6 TETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKA-------PLAYEVREAGA 58 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 + G +P ET++ IR+ RV +KGPL TPVG G +S NV LR+ + Y +RPVR Sbjct: 59 SVFRR-GIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVR 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + P+P D+V+ REN ED+YAGIE + Sbjct: 118 EFPNVPTPYAG-RGIDLVVVRENVEDLYAGIEHMQTPS---------------------- 154 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 +K S +G++++VR A E A A R V K NIMK EG K Q+A+E Sbjct: 155 -VAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEY 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 +I +I D Q++ RP +++VI N+NGD +SD Sbjct: 214 --------------------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDL 253 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + +GG+G AP ANIG+E A+FEA HG+APKYAG++ +NP +++LSA MMLR++ Sbjct: 254 TSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFAT 313 Query: 373 ADLIVKGMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI + + +T D G K +E+ +AII+N+ Sbjct: 314 ADLIENALLYTLEEGRVLTGDVVGYDRG---AKTTEYTEAIIQNL 355 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 115/392 (29%), Positives = 174/392 (44%), Gaps = 53/392 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG ++ A LKV+ + ++ +I G K + G + Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVI-------LEAGAELEIEKIEIGFKVYSM-GNPSGI 53 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + ++ +V +K P+TTP GGG +SLNV +R+ L LY +RP Y P Sbjct: 54 EPSSWESLKRTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY--APFIHTKH 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN ED+Y GIE + +K + + Sbjct: 112 PGIDLVIIRENEEDLYGGIEHRQG-----------------------VDSFQALKIMTRQ 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 GT+R++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 149 GTERIIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEY------------ 196 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I + I D ++ P +DV+ NL GD +SD G +G+ Sbjct: 197 --------PQIEKEHWIIDIGSAKLADNPQSFDVLVLANLYGDILSDVAVQIAGSVGLGA 248 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG E ++FEA HG+AP+ AGQ+ NP ++L+A ML H+G AD + I Sbjct: 249 SANIGHEYSMFEAIHGSAPRRAGQNVANPSGLLLAAVQMLIHIGQNAVADRVYNAWLKTI 308 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 TYD R + EF +I+N+ Sbjct: 309 EEGIHTYDIFREGVSKVKVGTREFARHVIKNL 340 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 121/389 (31%), Positives = 182/389 (46%), Gaps = 55/389 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I GDGIG ++ A+L ++ A + I I GEK + + ++ Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEAR-------IRLETIEVGEKLYVKH-YSSGISEQS 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELT 147 + I V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + Sbjct: 59 WESIERTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL---HPNL 115 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 ++ I REN ED+YAGIE+ R + +K S G + Sbjct: 116 NLTIIRENEEDLYAGIEY-----------------------RQTHNMYESVKLISRTGCE 152 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 +++R A EYA+ N+R VT + K NIMKF++G F ++A+E Sbjct: 153 KIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEY--------------- 197 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 +I + I D ++ +P +DVI NL GD ISD A G +G+A AN Sbjct: 198 -----PQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSAN 252 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG+ A+FEA HG+AP AGQD NP ++ +A MML H+G + A LI + I Sbjct: 253 IGEHYAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDG 312 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D K + EF + +++ + Sbjct: 313 MHTADIYNKDHSTKKVGTKEFAEEVVKRL 341 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 364 bits (934), Expect = 4e-99, Method: Composition-based stats. Identities = 112/399 (28%), Positives = 186/399 (46%), Gaps = 71/399 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG +V P +K+++ E ++ G + + YG LP + Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPED 52 Query: 88 TLDLIREYRVAIKGPLTTPVGG---GIRSLNVALRQELDLYICLRPVRYY-------QGT 137 T++ +E + + G +T+P G +S + LR+ LY +RP+ + + Sbjct: 53 TIEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIA 112 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + D+VI REN+ED+Y G E R I Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRE------------------------RLENDTAIA 148 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G++R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 149 ERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY----- 203 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 I D + D+ ++ P ++DVI N+ GD +SD +A + Sbjct: 204 ----------------NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP ANIGD+ ALFE HG+AP AG+ NP + ILS M+ ++G E DLI Sbjct: 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ + K VT D LK + GD I+ + Sbjct: 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEILNYI 340 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 364 bits (934), Expect = 4e-99, Method: Composition-based stats. Identities = 98/425 (23%), Positives = 169/425 (39%), Gaps = 59/425 (13%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 121 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 177 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 178 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 235 Query: 118 LRQELDLYICLRPVRYYQ----GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAE 173 LR L ++ LRP + + E D+++ RE + IY G Sbjct: 236 LRSGLKVFANLRPASVLPQLVDASTLKKEVAEGVDLMVVRELTGGIYFG----------- 284 Query: 174 KVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNI 233 + G K E G + + R+ R A E A R + V K N+ Sbjct: 285 -------KPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFETAQKR-RGKLCSVDKANV 336 Query: 234 MKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRP 293 ++ + ++ +A E ++ + + D Q++ P Sbjct: 337 LEASM-LWRKRVTAMASEY--------------------PDVELSHMYVDNAAMQLVRNP 375 Query: 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVN 352 ++D I N+ GD +SD + G IG+ P A++G+ LFE HG+AP AGQDK N Sbjct: 376 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKAN 435 Query: 353 PGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDA 411 P + +LSA M+LR+ +G AA I + ++ T D G KL+ C E G+ Sbjct: 436 PLATVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEA--GTKLVGCKEMGEQ 493 Query: 412 IIENM 416 +++ + Sbjct: 494 VLKAV 498 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 362 bits (929), Expect = 2e-98, Method: Composition-based stats. Identities = 121/388 (31%), Positives = 174/388 (44%), Gaps = 55/388 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + GDGIG ++T A++ ++ AA + + GE+ G +P E Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA-------GAHLDAEYVEVGEQVYLR-GNTSGIPQEA 75 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 D I RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P D Sbjct: 76 WDSIARTRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHPDMD 133 Query: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 +VI REN ED+YAGIE R + +K + G++R Sbjct: 134 VVIVRENEEDLYAGIEH-----------------------RQTQDVAQCLKLITRSGSER 170 Query: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 + R A EYA + R +T + K NIMK T+G F ++ARE Sbjct: 171 IARYAFEYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY---------------- 214 Query: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 EI I D + + RP +YDV+ NL GD +SD A G +G+ NI Sbjct: 215 ----PEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQMTGSVGLGGSVNI 270 Query: 329 GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 G A+FEA HG+AP A +D NP ++L+A MLRH+ A ++ + Sbjct: 271 GSGGAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHLKLDSIAAKVMNAWLCTLEEGI 329 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + F +A+IE + Sbjct: 330 HTVDIAG-AHTKERAGTRRFTEAVIERL 356 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 110/392 (28%), Positives = 174/392 (44%), Gaps = 66/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIGV+V A L +++ + + ++ G+ + G L Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TAL 52 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ETL+ + E R + G + V LR+E DL+ LRPV+ G P Sbjct: 53 PEETLEAVGEARATLFGAAG----ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY--- 105 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D VI REN+ED+Y G E + + + + Sbjct: 106 PDLDFVIVRENTEDLYVGDE------------------------EYTPEGAVAKRIITRT 141 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ + A +YA VT VHK N++K T+G F+D Y++A E Sbjct: 142 ASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY------------ 189 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ D DA ++ +P E+ I NL GD +SD A +GG+G+AP Sbjct: 190 --------PQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAP 241 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG++ ALFE HG+AP+ AG++ NP ++IL+ +ML+H+ + A I K ++ + Sbjct: 242 SANIGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTL 301 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT D L E I ++ Sbjct: 302 AEGLVTPDL------GGKLGTMEMAAEIARHL 327 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 360 bits (924), Expect = 5e-98, Method: Composition-based stats. Identities = 114/392 (29%), Positives = 176/392 (44%), Gaps = 65/392 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I IEGDGIG +V PA +V++A + ++E G ++ + G V P Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PE 53 Query: 87 ETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 ET++ I + G T+P G LR+ LDLY +RP + P P Sbjct: 54 ETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRP---VPGSRP 110 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+VI REN+E +Y E + I S++ Sbjct: 111 -GVDLVIVRENTEGLYVEQERR------------------------YLDVAIADAVISKK 145 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 ++R+ RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 146 ASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDF------------ 193 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++D+I D Q+++RP +DVI NL GD +SD A VGG+G+AP Sbjct: 194 --------PLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAP 245 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 NIGD A+FE HG+AP AG+ NP + ILSA MML ++G EAA + K ++ + Sbjct: 246 SGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVL 305 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D F +A++E + Sbjct: 306 ERGPRTPDL------GGDATTEAFTEAVVEAL 331 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 360 bits (923), Expect = 8e-98, Method: Composition-based stats. Identities = 118/410 (28%), Positives = 184/410 (44%), Gaps = 63/410 (15%) Query: 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY 69 Q + +IEGDGIG +++ ++ K+ AA I W Sbjct: 20 QPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESCD 72 Query: 70 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 129 S +P + I + VA+KGPL TP+G G RSLN+ LR+ L+ +R Sbjct: 73 V---SPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVR 129 Query: 130 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 189 P + +G + E D+V+ REN+E Y+GIE + Sbjct: 130 PAKSIEGFKTTY---ENVDLVLIRENTEGEYSGIEHIVCPGVVQ---------------- 170 Query: 190 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 IK + + ++R++R A EYA A R V +VHK I + +G F + +L+ Sbjct: 171 -------SIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELS 223 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY--DVIACMNLNGD 307 +E ++ ++ + D + +++ P+ Y V C NL GD Sbjct: 224 KEY--------------------PDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGD 263 Query: 308 YISDALAAQ-VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 +SD + G +G+ P ANIG + ++FEA HG+AP AGQDK NP +++LS+ MML H Sbjct: 264 ILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNH 323 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 MG T AD I + I + R D A S F +A+I+ + Sbjct: 324 MGLTNHADQIQNAVLSTIASG----PENRTGDLAGTATTSSFTEAVIKRL 369 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 359 bits (922), Expect = 9e-98, Method: Composition-based stats. Identities = 100/404 (24%), Positives = 156/404 (38%), Gaps = 56/404 (13%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG +V P ++V++AA K K+++ + Q Sbjct: 1 MITNQQYKIAVIPGDGIGNEVVPEGIRVLEAASAK---FGFKLAFTTYDWSCARY--HSQ 55 Query: 81 DVWLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 +P++ ++ +R+ G + P + +L + +R+E D Y+ LRPVR G Sbjct: 56 GSMMPSDGIERLRDSDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGV 115 Query: 138 PSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ K P D I REN+E Y+ + G Sbjct: 116 PCPLANKKPGDIDFWIVRENTEGEYS-------------------QVGGRMFAGTEHEFV 156 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + GT R++R A + A R+ VT K N + + + + + E Sbjct: 157 TQEAIFTRRGTDRIMRYAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEY--- 213 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I D + + P +DV+ NL GD +SD Sbjct: 214 -----------------PDIRTDQYHIDILAARFAMSPERFDVVVGSNLFGDILSDLGPG 256 Query: 316 QVGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 G I +AP ANI E ++FE HG+AP AGQ NP I S MML H+G EA Sbjct: 257 ITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIWSGAMMLEHLGQPEA 316 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I++ +E + D D + G I + Sbjct: 317 AAAIMQAIETVLTH----PDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 103/389 (26%), Positives = 174/389 (44%), Gaps = 64/389 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + IEGDGIG ++ PA +KV+DA + + + G + G + Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNN 52 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 L+ I+ + G +TT +S+ + +R+ELDLY +RPV+ G + V Sbjct: 53 DLETIKGCDAVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGI-TGVTGRNDF 111 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D +I REN+E +Y+GIE + + +G++ Sbjct: 112 DFIIVRENTEGLYSGIE------------------------EIGPELSWTKRVVTRKGSE 147 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A + A ++ +T+VHK N++K ++ F D Q A Sbjct: 148 RIAEYACKLAKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTA------------------ 187 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 + + +D++ D+ +++RP YD++ NL GD +SD AA VG +G+ P AN Sbjct: 188 ---SANGVEYEDMLVDSMAYNLIMRPERYDIVVTTNLFGDILSDMCAALVGSLGLVPSAN 244 Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 IG++ A FE HG+AP AG+ NP + IL +M+L MG + +I + + + K Sbjct: 245 IGEKYAFFEPVHGSAPDIAGKGIANPLAAILCVKMLLEWMGEPR-SQIIDEAIAYVLQKK 303 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D E G+A+ E + Sbjct: 304 IITPDL------GGTASTMEVGNAVAEYV 326 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 133/394 (33%), Positives = 191/394 (48%), Gaps = 60/394 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I+GDG+G DV A L V+DA +K I ++ G + + YG + L Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKK---FNLDIEYVPAVAGLNTVEKYGTN--L 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 P ETLD ++E +KGP TTP G + S NV +R+ DLY +RP + PS Sbjct: 59 PKETLDTLKETDCVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--- 115 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 DMVI REN+E +Y+G++++ + + IGI+ + Sbjct: 116 KPNVDMVIVRENTEGMYSGLDFRVN-----------------------QETTIGIRVITR 152 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + +R+V+ A + A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 153 KACERIVKYAFKLAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKK------------ 199 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ D DA Q + +P YDVI NL GD ISD A VGGIG Sbjct: 200 --------HPDVKADDAHVDAITQWFIKQPEFYDVIVTENLFGDIISDEAAMVVGGIGTG 251 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 ANIGD+ A+FE HG+ PKY G DKVNP I+S +MML M + EA I + Sbjct: 252 ASANIGDKYAMFEPIHGSVPKYTGMDKVNPIGTIMSVKMMLDWMDYKEAGKAIEDAVYKV 311 Query: 384 INAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +TYD KCSE G I + Sbjct: 312 LEEGKILTYDL------GGTAKCSEVGKEIASKV 339 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 56/398 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIG++V A ++VV+ + G I + I G + +G+ ++ Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVS 101 Query: 86 AETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + LD +R++ + G + P + L +ALR L LY +RPVR + GT P+ Sbjct: 102 EDCLDTLRKFDAGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLN 161 Query: 143 HP-ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 E D ++ RENSE Y+G + G + P + Sbjct: 162 TATEGIDWMLVRENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMF 202 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + G +R++R A E A + R +T+V K N M+ + ++A++ Sbjct: 203 TRVGIERIMRFAFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDF--------- 253 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++ ++ DA +++ +P D I NL+ D +SD AA G IG Sbjct: 254 -----------PDVTWDKMLVDAMTVRMVAKPQSIDTIVGTNLHMDILSDLAAALAGSIG 302 Query: 322 IAPGANIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 +AP +N+ ++FE HG+A G+ NP + SA ML +G EAA ++ Sbjct: 303 VAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLSWLGEKEAAKQLMD 362 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E A +T D DA+ + + Sbjct: 363 CVEKVCAAGILTPDL------GGTSNTQGVVDAVKKEI 394 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 355 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 114/390 (29%), Positives = 181/390 (46%), Gaps = 56/390 (14%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P + GDG+G ++ ++L+++ ++ +I I G+K + G + Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEII-------FEAGAEIQIDTIEIGQKIYEK-GWPSGISD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 + ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P Sbjct: 54 SGWETLKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----K 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+VI REN ED+Y+GIE+ R K +E + Sbjct: 109 MDIVIIRENEEDLYSGIEY-----------------------RQTLDTYNCTKVITESTS 145 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 146 ERICRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEY-------------- 191 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +I ++ I D +I P ++DVI +NL GD ISD A G +G+ Sbjct: 192 ------PDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGLGGSI 245 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+E A+FEA HG+AP A QD NP ++ +A ML ++G E A + + + Sbjct: 246 NIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKS 305 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D + + +F + II N+ Sbjct: 306 GVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 99/406 (24%), Positives = 172/406 (42%), Gaps = 63/406 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ + + GDGIG +V +KV++ EK K+++ E + G + G L Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEK---FGFKLNFNEFFVGGAAIDHCGYP--L 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGT 137 PAETL E + G + P + R + LR+ L+ LRP Y+G Sbjct: 57 PAETLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGL 116 Query: 138 P--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 P++ + DMV+ RE + IY G + + + Sbjct: 117 EKFCPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGS-------------------Q 157 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ RAA E A+ + VT V K N+++ + +++ ++A++ Sbjct: 158 TKAFDTEVYYKYEIERIARAAFEAAMKRN-KKVTSVDKANVLQ-SSILWRETVTEMAKDY 215 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 E+ ++ + D Q++ P +DV+ C N+ GD ISD Sbjct: 216 --------------------PEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDE 255 Query: 313 LAAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 A G +G+ P A++ + L+E G+AP AG+ NP + ILSA MMLR+ Sbjct: 256 AAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLN 315 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EAAD I ++ + + T D D + + +E G I + + Sbjct: 316 EAADAIESAVQKVLASGHRTADLA---DDSTPVSTAEMGTLITQAI 358 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 104/396 (26%), Positives = 164/396 (41%), Gaps = 63/396 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + I IEGDGIG +V PA V++A K ++E G ++ + G V Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV 53 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P TL+ + + G T+P G +R++LDL+ +RP +++ P Sbjct: 54 --PEATLEAVTHTDATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHHP---VP 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+++ REN+E +Y E I Sbjct: 109 GSRP-GVDLIVVRENTEGLYVEQERSYLEG----------------------EIAIADTV 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + + R+ A A + R + + HK N++ T+G F + A Sbjct: 146 ITRKASARIGEYAARLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARF-------- 197 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 E+ +D+I D Q++ P +DVI NL GD ISD A VGG+ Sbjct: 198 ------------PEVKTQDIIIDNCAMQLVRNPERFDVIVTTNLFGDIISDLTAGLVGGL 245 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 GIA NIG + A+FE HG+AP AG+ NP + ILS MML H+G EAA + + Sbjct: 246 GIAASGNIGIKHAVFEPVHGSAPDIAGKGIANPAATILSGVMMLDHLGEHEAARRVEAAV 305 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D +F +A+ ++ Sbjct: 306 DKVLQEGPRTPDL------GGNATTLQFAEAVARSL 335 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 352 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 57/400 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I DGIG +V A L+V++A ++ G+ I G + G V + Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKR--SGDFSIHTETFDWGSDYYKKNG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ ++++ G + P + L + + Q D Y +RP + G P+ Sbjct: 58 PADGLEQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 ++ P D VI RENSE Y+G +A PE G + Sbjct: 118 RNCGPGDLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVA 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G R++R A + A A R +T+V K N + + + ++++E Sbjct: 159 IFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ ++ DA ++ L+P D I NL+ D +SD A G Sbjct: 212 -------------PDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHADILSDLAGALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+AP ANI E ++FE HG+A G+ NP + +A ML H+G +AA + Sbjct: 259 LGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFWTAAQMLEHLGEKDAATRL 318 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E A +T D + DA+ E + Sbjct: 319 MSAVERVTEAGILTPDV------GGTADTQQVTDAVCEAI 352 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 352 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 99/399 (24%), Positives = 160/399 (40%), Gaps = 55/399 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGIG +V LKV+ +K Y + + +G+ + Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADM--FLWNSEYYLQHGR--MM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P LD+++ Y + G + P + L + +R+ Y+ LRPV+ +G P Sbjct: 58 PENGLDILKNYDAILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 142 KHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 H E + VI REN+E Y+ G + + Sbjct: 118 IHQERPINFVIVRENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTI 158 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +GT+R+ R A +YA + V K N + + + + +A E Sbjct: 159 ITRKGTERIARYAFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEY-------- 210 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I ++ DA + RP VI NL GD +SD +A VGG+ Sbjct: 211 ------------PDIQLEKYYIDALAAYFVQRPDTLQVIVASNLFGDILSDLGSALVGGL 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GI+P ANI E ++FE HG+AP AG+ K NP + I SA +ML+ +G + A +I+ Sbjct: 259 GISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQIWSAALMLQSLGREDLASIIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K +E D +E G+ I+ + Sbjct: 319 KAIEKVTEHGEK-----LTEDLGGNSTTAEMGEEIVRQI 352 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 107/401 (26%), Positives = 166/401 (41%), Gaps = 69/401 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GDGIG +++ + L +++A + + ++ G+ + G+ Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAIND---NFPLSLEIKKLEAGDAVLKNTGK-- 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 LP ET + I+ +K P+ + + V LR+ LDLY +RP + Y PS Sbjct: 56 ALPDETFEAIKNSDACLKAPVG----ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 + D+VI REN+ED+Y G E+ + + S Sbjct: 110 -RDDVDLVIVRENTEDLYTGEEFDIG------------------------DAAVAFRIIS 144 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 E+ +KR+ A A VT VHK N+MK T+G F ++A + Sbjct: 145 EKASKRIANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDF---------- 194 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ +++ DA ++ +P +DVI NL GD +SD A VGG+G+ Sbjct: 195 ----------PDVKFEEMYVDACAMNLIRQPQLFDVIVTTNLFGDILSDESAQVVGGLGM 244 Query: 323 APGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EAADL 375 AP ANIGD LFE HG A AG+ NP S ILS +MML +G E Sbjct: 245 APAANIGDNFGLFEPVHGAAFDIAGKQIANPTSFILSIKMMLDWLGNKHNDQKCIEVGQK 304 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D EF II + Sbjct: 305 LEDVVYDIVKNNIKTKDI------GGDKTTMEFTKEIISRL 339 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 113/393 (28%), Positives = 176/393 (44%), Gaps = 69/393 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG VT A+ +V++A + + +V G +P E Sbjct: 40 TVTLIPGDGIGPLVTGAVEQVMEAMHAPVHF--------------ERYEVLGNMRKVPEE 85 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 ++ ++ +V +KG L TPVGGG+ SLN+ LR+ELD++ L G V E Sbjct: 86 VIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGL---VTRHENV 142 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E Y+G+E + E +K ++ ++ Sbjct: 143 DIVVIRENTEGEYSGLEHEVVPGVVE-----------------------SLKVITKFCSE 179 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ R A EYA N+R VT VHK NIMK +G F + ++A+ G Sbjct: 180 RIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG------------- 226 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I ++I D Q++ +P ++DV+ NL G+ I++ A GG G+ PG N Sbjct: 227 -------ITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGN 279 Query: 328 IGDECALFEATHGTA----PKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 +G E A+FE K Q K NP +++LS+ MMLRH+ + AD + ++ Sbjct: 280 VGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQV 339 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I R D E DA+I + Sbjct: 340 IKEGK-----YRTKDLGGDCTTQEVVDAVIAAL 367 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 109/407 (26%), Positives = 170/407 (41%), Gaps = 56/407 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + + + + I I GDG G + LKV+ AA K + + G + Sbjct: 7 KEDRTTMQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGK---EGFALETTVLDWGGEYYL 63 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRY 133 G+ LP + ++ ++ Y G + P G + + + LR ELD YI LRPV+ Sbjct: 64 RTGE--VLPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKL 121 Query: 134 YQGTPSPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 Y G +P+ K PE D V+ REN+E +YAG G K P Sbjct: 122 YPGVETPIAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTP 162 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + I + +G +R VR A EY R VTL K N++ F ++ ++ Sbjct: 163 DEVAIQTSINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGE 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 E +I DA ++ P +DVI N+ GD I+ Sbjct: 223 EY--------------------PDIERDYAHVDAICMWMVKNPEWFDVIVTDNMFGDIIT 262 Query: 311 DALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 D A GG+GIA G N+ E ++FE G+APKY G++ +NP + + + MML +G Sbjct: 263 DLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVINPLAAVCAGAMMLEQLGE 322 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA I + ++ + L G E GD ++ ++ Sbjct: 323 TGAAARIEEAVKKVCAGH-----LKSLAAGRMGYGTDEVGDLVVSHL 364 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 98/401 (24%), Positives = 159/401 (39%), Gaps = 58/401 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDGIG +V PA + + E G + + G + +G V + Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMM 57 Query: 85 PAETLDLIREYRVAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 PA+ L+ +R+ + G P + L + + Q LD Y +RP R G P+ Sbjct: 58 PADGLEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 K E D VI RENSE Y+G+ + P + Sbjct: 118 KRCTAEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAATDVS 158 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R++R A A + R +T+V K N + + + +++RE Sbjct: 159 MMTRAGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREF------- 211 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + DA +++ RPA D I NL+ D +SD AA G Sbjct: 212 -------------PDVRWDKELVDAATARMVNRPASLDTIVATNLHADILSDLAAALAGS 258 Query: 320 IGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +GIAP NI E ++FE HG+A G+ NP S M+L H+G +AA + Sbjct: 259 LGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGTFWSVVMLLEHLGEHQAAARM 318 Query: 377 VKGMEGAINAKTVTYDFE-RLMDGAKLLKCSEFGDAIIENM 416 ++ +E T D D + A+ +++ Sbjct: 319 MRAVESV------TADQALHTRDLGGTATTEQVTQAVCQHL 353 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 130/394 (32%), Positives = 187/394 (47%), Gaps = 31/394 (7%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G ++ A V+D A KI W G+++ + L Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAA---RLSGFKIDWDVHQAGQRALAE--SESLL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQ-GTPSPVKH 143 P TL+ IR A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR + Sbjct: 57 PDATLNSIRTNGAALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLPIASTQEEPE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+V+ REN+ED+YAG+E+ S A V++ L G P + +KP + Sbjct: 117 RPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTP 172 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R+V A +A + R V V TEG F ++A Sbjct: 173 HGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAAR------------ 220 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 I + V A ++ P +DV+ NL GD ISD AA VG +G+A Sbjct: 221 --------HPSIASRTVPVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVA 272 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 PGANIG A+FEATHG+AP++AG ++NP ++I S M+L H+G E A I +E Sbjct: 273 PGANIGAHHAVFEATHGSAPEFAGSGRLNPTALIFSGCMLLDHLGEHETAARIRAAVEDV 332 Query: 384 INAK-TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A +T+D A EF A+ + + Sbjct: 333 VAAGEVLTFDLLAPQRSADAATTVEFTRAVTDRL 366 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 127/397 (31%), Positives = 183/397 (46%), Gaps = 59/397 (14%) Query: 23 VPENPII--PYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I I GDGIG ++ +++ V+DA W Y G + G Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGD 59 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP ET+ I ++A+KGPLTTP GGG RS+NV LR+E +L+ +RP P Sbjct: 60 P--LPRETIQSIHHNKLALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IP 113 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D+ + REN + YA E D P + Sbjct: 114 GGRFENVDITLIRENLDGFYAAFEHYMPIGD------------------DPHAVAMCAGF 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G R++R A EYA+ N R VTLVHK NI+K G F + G ++A+E Sbjct: 156 NTRTGCHRIIRYAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I ++ I DA Q++L P +DVI NL GD +SD +A +GG+ Sbjct: 208 -----------EGRIAFEERIVDACAMQLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGL 256 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+APG NIG + A+FEA HG+AP AG+ NP +++L+A MML H+G T+ A + + Sbjct: 257 GLAPGGNIGKQAAIFEAVHGSAPDIAGKGIANPLALMLAAAMMLDHVGKTDLATRLRNAI 316 Query: 381 E-GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D K E A+I + Sbjct: 317 RITTLEDGIRTPDL------GGTAKTRELTQALISRI 347 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 105/402 (26%), Positives = 168/402 (41%), Gaps = 66/402 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG +V LKV++ +K + + + G + +G+ LP E Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKK---TGKTFEKVFGHIGGDAIDRFGEP--LPEE 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLYICLRPVRYYQGTP-- 138 T + E G + P + +ALR+ L+LY +RP++ Y+ Sbjct: 57 TKKICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHV 116 Query: 139 SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K D+V RE S +Y G E G Sbjct: 117 SPLKEKVIGSGVDLVTVRELSYGVYYGQP-----------------------RGLDEEKG 153 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + +R+ R A E A N R VT V K N++ ++ ++ ++ARE Sbjct: 154 FDTMIYDRKTVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREY--- 208 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + D Q++L+P+++DVI N+ GD +SD AA Sbjct: 209 -----------------PDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAA 251 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A+ GD+ L+E G+AP AG++ NP + ILS MML H G E A Sbjct: 252 LPGSLGLLPSASFGDKN-LYEPAGGSAPDIAGKNIANPIAQILSLAMMLEHSFGMVEEAR 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +E I T D + K + S+ GD I + + Sbjct: 311 KIERAVELVIEEGYRTRDIAEDPE--KAVSTSQMGDLICKKL 350 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 93/402 (23%), Positives = 154/402 (38%), Gaps = 60/402 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I + GDGIG +V KV++ K + +I+ + G + +G LP T Sbjct: 4 IAILAGDGIGPEVMVEAKKVLNTVASK---FDFEITTQDYDIGGAAIDNHGN--ALPDST 58 Query: 89 LDLIREYRVAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + E + G + P + R + LR DL+ +RP S Sbjct: 59 MAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLS 118 Query: 142 K-----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + D+++ RE + DIY G E G Sbjct: 119 TLRSDISEQGFDVLVIRELTGDIYFGEPKGRRGEG-------------------EEETGF 159 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 S KR+ A + A + + VT V K N++ T ++ ++A E Sbjct: 160 DSMFYSRREVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEY---- 213 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D Q++ P ++DV+ C NL GD +SD A Sbjct: 214 ----------------PDVELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAMI 257 Query: 317 VGGIGIAPGANIG-DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G +G+ P A++ D ++E G+AP AG NP + ILSA +MLR+ + AA Sbjct: 258 TGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAAK 317 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + A++ +T D + SE GD I + + Sbjct: 318 AIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 116/398 (29%), Positives = 169/398 (42%), Gaps = 61/398 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 L + I GDGIG + + A+ ++ A I + EI Sbjct: 15 LKYGGKYTVTLIPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNKSS 67 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 L E + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G + Sbjct: 68 GDAL-HEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT 126 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D I REN+E Y+G+E ++ E +K Sbjct: 127 ---RHDNVDFAIIRENTEGEYSGLEHQSVPGVVE-----------------------SLK 160 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E +KR+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 161 IITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDA----- 215 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 I KD+I D Q + RP ++DV+ NL G +S+ +A VGG Sbjct: 216 ---------------ITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGG 260 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ PGAN G + ALFE G+ + NP + ILSA +MLRH+G + ADLI Sbjct: 261 PGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINA 320 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I D +F AI+E M Sbjct: 321 ATYSVIEEGK-----TLTKDLGGSASTGDFTHAILERM 353 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 111/392 (28%), Positives = 172/392 (43%), Gaps = 64/392 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V A + V+D + ++ G++ + +G L Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDEL-------DVDFDYIYGIAGDECNEEHGTP--L 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 P ET+D++R+ + G + V +RQE+ ++ LRPV+ Y T S Sbjct: 60 PQETIDIVRDSDACLFGAAG----ETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E D +I REN+E +Y + E I + + E Sbjct: 113 ENVDFMIVRENTEGLYIA-----------------------DQEEETEDGAIAKRVITRE 149 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R++ A +YA N+R VT VHK N++K T+G FK Y++ + Sbjct: 150 AEERIIDYAFQYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKY------------ 197 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +I +D DA ++ +P E+ V+ NL GD +SD A VGG+G+ P Sbjct: 198 --------PDIDTEDFYVDATAMYLVTQPQEFQVVVTTNLFGDILSDEGAGLVGGLGLIP 249 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 ANIG + ALFE HG+AP AGQ K NP +++LSA MMLR++G +AAD + + Sbjct: 250 SANIGADGALFEPVHGSAPDIAGQQKANPIAMMLSAIMMLRYLGENDAADKFDAAILKVL 309 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D E A+ + Sbjct: 310 SEGK-----TLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 340 bits (873), Expect = 5e-92, Method: Composition-based stats. Identities = 106/399 (26%), Positives = 183/399 (45%), Gaps = 56/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +V PA +V++ K +++++Y G ++ Q G+ L Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSK---HGLSFNFIDLYAGFQTFQETGK--AL 76 Query: 85 PAETLDLIRE-YRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P ET+ +++E + A+ G + +P G S VALR+E+ L+ +RPV+ +G Sbjct: 77 PDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + DMVI REN+ED+Y IE K Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDK------------------ATGTRVADATKRI 173 Query: 202 SEEGTKRLVRAAIEYAIAN----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 SE T+R+ A++ A+ + ++T+ HK N++ ++G F++ ++ Sbjct: 174 SEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYE------- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 N + +I + I D+ + ++ P +DVI NL GD +SD AA V Sbjct: 227 ---------SNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALV 277 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G +G+ P AN+G E + E HG+AP AG+ NP + I S +ML +G EAA I Sbjct: 278 GSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIY 337 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ + ++ + D + D ++ + Sbjct: 338 KAVDANLREGSI-----KTPDLGGKASTQQVVDDVLSRL 371 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 111/397 (27%), Positives = 168/397 (42%), Gaps = 57/397 (14%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 ++VP I GDG+G ++ A+L ++ A +S + G + Sbjct: 5 SMSVP----ITVAYGDGVGPEIMEAVLFILKEARA-------DVSIETVDIGHNQYKKE- 52 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + + I R+ +K P TP G G +SLNVALRQ L LY+ +RP Y P Sbjct: 53 WTSGIAPSAWESISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPV 110 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+VI REN ED Y+G+E K E +K Sbjct: 111 VGTKHPDLDVVIIRENEEDTYSGVEHK-----------------------LSEDTHECVK 147 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + ++++ A YA A++R VT K NIMK T+G ++A+ Sbjct: 148 ISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGY------- 200 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I I D + +I P ++DV+ NL GD +SD ++ G Sbjct: 201 -------------PDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVSLSSGS 247 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 IG+ ANIGD A+FEA HG+AP AG++ NP ++ +A ML H+G + A +I Sbjct: 248 IGLTGSANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQLDKAGVIRNA 307 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T D + EF AI+ N+ Sbjct: 308 FLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVGNL 344 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 340 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 105/399 (26%), Positives = 157/399 (39%), Gaps = 58/399 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GDG+G +V A KV+ A E G S+ +G+ + Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAE--VHGGLSFSFTAFPWSCDYYLEHGK--MM 59 Query: 85 PAETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + + + ++ G + P + L + +R+EL+L I +RP + G SP Sbjct: 60 PEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSP 119 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + HP D V+ RENSE Y+ E+G + R + I Sbjct: 120 LLHPNDFDFVVIRENSEGEYS--------------------EVGGRIHRGDDEIAIQNAV 159 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + + T+R++R A E A R VT K N + + + Q A + G Sbjct: 160 FTRKATERVMRFAFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSG------ 212 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I DA + RP +DVI NL GD ++D ++ +G I Sbjct: 213 --------------IETSSQHIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSI 258 Query: 321 GIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GIAP ANI ++FE HG+AP AGQ NP I +A++ML H G E I+ Sbjct: 259 GIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKIL 318 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ME T D +E D I + Sbjct: 319 DVMEQVTADGIKTRDI------GGQSTTAEVTDEICSRL 351 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 116/413 (28%), Positives = 186/413 (45%), Gaps = 48/413 (11%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE----KSTQ 76 + + Y+ GD G D+ L V+ + I W+ G KS Sbjct: 9 KERKDRYKVCYMPGDDSGFDMMEGALVVL-------LSMDLPIDWVRADLGWCMWEKSVN 61 Query: 77 VYGQDV----WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPV 131 +GQ +P ET+D IR + +T+ G G +S + +RQ DLYI LRP Sbjct: 62 KFGQGDPRCNTVPPETIDKIRSSDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPA 121 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + SP+K D+V+FREN+ED+Y+ +E+ + + K G+++ R Sbjct: 122 KTLPDLGSPLKGDPKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHK------GMERFRKM 175 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 + + S G +R++RAA EYA + R V +K N+++ T+G K ++A+E Sbjct: 176 GDVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKE 235 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 I + ADA ++ P +Y VI N+ GD +SD Sbjct: 236 YEQY------------------GITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSD 277 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG+G AP NIG+ A+FE G+ PKYA Q +VNP +++L+++MML ++G + Sbjct: 278 EASQLTGGLGFAPSGNIGENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLGLDQ 337 Query: 372 AADLIVKGMEGAINA---KTVTYDFERLMDGA-----KLLKCSEFGDAIIENM 416 A I + + KT+TYD R E AI + + Sbjct: 338 AGQKIEWAINEVLKENRPKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 99/405 (24%), Positives = 161/405 (39%), Gaps = 59/405 (14%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + I + GDGIG +V V+ A + + E+ G + + G V Sbjct: 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAG---SLEGLEFDFKEMPVGGAALDLVG--VP 98 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVA------LRQELDLYICLRPVRYYQ-- 135 LP ET + + G + LR++L ++ LRP Sbjct: 99 LPEETFTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQL 158 Query: 136 --GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 + + E DM+I RE + IY G E G+ E Sbjct: 159 VDASTLKKEVAEGVDMMIVRELTGGIYFG------------------EPRGITINENGEE 200 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 G+ + + R+ R A E A R + V K N++ + ++ LA E Sbjct: 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEY- 257 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 ++ + + D Q++ P ++D I N+ GD +SD Sbjct: 258 -------------------PDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEA 298 Query: 314 AAQVGGIGIAPGANIGD-ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 + G IG+ P A++G+ LFE HG+AP AGQDK NP + ILSA M+L++ +G + Sbjct: 299 SMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEK 358 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I + A+N T D G KL+ C E G+ +++++ Sbjct: 359 AAKRIEDAVVDALNKGFRTGDIYSP--GNKLVGCKEMGEEVLKSV 401 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 98/407 (24%), Positives = 158/407 (38%), Gaps = 66/407 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVW 83 + I I GDGIGV+V P L+ +DA + + ++ I +GQ Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRR---FGLRFAYEPIEWASCDYYAKHGQ--M 93 Query: 84 LPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + G + P + + R+E D Y+ LRP R + G P Sbjct: 94 MPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 153 Query: 140 PV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ + D +I REN+E Y+ + G + Sbjct: 154 PLAGRKAGDIDFMIVRENTEGEYSAVG-------------------GTMFEGTEREFVVQ 194 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + GT+R+++ A E A +T+ K N + + + ++A Sbjct: 195 QAVFTRHGTERVLKFAFELAQRRA-KRLTVATKSNGIAISMPWWDARAAEMAARY----- 248 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ D + +++P +DV+ NL GD +SD A Sbjct: 249 ---------------PDVAWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACT 293 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-----W 369 G IGIAP AN+ E +LFE HG+AP AG+ NP ++I SA MM+ +G Sbjct: 294 GTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPA 353 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 EA D IV +E + T D E GDAI+ ++ Sbjct: 354 REAHDAIVAAIEHVLKHGPRTRDM------GGRASTREVGDAIVAHL 394 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 95/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 10 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE-- 60 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 61 ----DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 116 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 117 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 150 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 151 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 205 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 206 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 250 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 251 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 310 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE II ++ Sbjct: 311 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDIIRHI 345 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 338 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 98/397 (24%), Positives = 165/397 (41%), Gaps = 62/397 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I GDGIG ++ A+ + + + E+ + + Sbjct: 47 YGGRNTVTLIPGDGIGPEMVVAVQDIFRHI-------GVPVDFEELNLSGLDIKDEDSYL 99 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 E + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + G + Sbjct: 100 GAFNEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT- 158 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 D+VI R+N+E Y+ +E + S E +K Sbjct: 159 --RHNNVDLVIIRQNTEGEYSHLEHENVSGVIE-----------------------NLKV 193 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +EE ++ + A ++A +DR VT VHK NIMK +G F +++ Sbjct: 194 TTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSY-------- 245 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 I +I D Q++ P ++DV+ NL G+ +S+ A+ VGG Sbjct: 246 ------------PNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVSNIGASLVGGP 293 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 GI PG NIG + A+FE+ + T G+D NP S++ ++ +ML H+ +T ADLI Sbjct: 294 GIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLEHLEFTAYADLINSA 353 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + +T D ++F A+ + Sbjct: 354 ILKVVQRGVLTADV------GGSHTTTQFLSALKSEL 384 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 337 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 94/400 (23%), Positives = 160/400 (40%), Gaps = 67/400 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I GDGIG ++ + V A + + E++ + + Sbjct: 48 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEE-- 98 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGT 137 + IR RVA+KG + T +S N LR LDLY + + G Sbjct: 99 ----DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV 154 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 V + D++I REN+E Y+ +E ++ + E Sbjct: 155 ---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-----------------------S 188 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 +K ++ + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 189 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY----- 243 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 +I +++I D Q++ RP ++DV+ NL G+ +++ A V Sbjct: 244 ---------------PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLV 288 Query: 318 GGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 GG G+ GAN G A+FE AT T A ++ NP + +L++ MML H+ A I Sbjct: 289 GGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 348 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + +++ + + D SE +I ++ Sbjct: 349 RKAVLASMDNENM-----HTPDIGGQGTTSEAIQDVIRHI 383 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 337 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 155/400 (38%), Gaps = 68/400 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG +VT A LKV+ A E +++ G + +G+ P Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDE---AEGLGLAYEVFPFGGAAIDAFGEP--FPEP 56 Query: 88 TLDLIREYRVAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP--S 139 T + E + G + P G + ++LR+ DL+ LRP + + G S Sbjct: 57 TRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLS 116 Query: 140 PVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K D++I RE + IY G A+ Sbjct: 117 PLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAE-----------------------AWN 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + S+ +R+ R A E A R V V K N+++ E ++ ++ R Sbjct: 154 TERYSKPEVERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ ++ DA ++ PA +DV+ N+ GD +SD + Sbjct: 207 ---------------PDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLP 251 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLI 376 G +G+ P A++G +FE HG+AP AG+ NP + ILSA MML H G E A + Sbjct: 252 GSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKV 311 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ D F ++ ++ Sbjct: 312 EDAVAKALLE-------TPPPDLGGSAGTEAFTATVLRHL 344 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 95/408 (23%), Positives = 160/408 (39%), Gaps = 66/408 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVW 83 + I I GDGIG++V P ++V++AA K + + +G+ Sbjct: 4 HSFRIAAIPGDGIGLEVLPEGIRVLEAAALK---HGLALEFDTFEWASCDYYLQHGK--M 58 Query: 84 LPAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + +++Y G + P + + R+E D Y+ +RPVR + G P Sbjct: 59 MPDDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPC 118 Query: 140 PVKHPE--LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 + + + D V+ REN+E Y+ + G+ I Sbjct: 119 ALANRKVGDIDFVVVRENTEGEYSSLG-------------------GIMFENTENEIVIQ 159 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G R+++ A + A +R VT K N M + + +A Sbjct: 160 ESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHY----- 214 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA-CMNLNGDYISDALAAQ 316 + D + +L+P +DV+ NL GD +SD A Sbjct: 215 ---------------PHVSWDKQHIDILCARFVLQPERFDVVVVASNLFGDILSDLGPAC 259 Query: 317 VGGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-- 371 G IGIAP AN+ E +LFE HG+AP G++ NP ++I S +ML +G + Sbjct: 260 AGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDER 319 Query: 372 ---AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A D ++ +E I +VT D L + G AI + + Sbjct: 320 YQRAHDDMLNAIERVIADGSVTPDM------GGTLSTQQVGAAISDTL 361 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 336 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 99/402 (24%), Positives = 165/402 (41%), Gaps = 59/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG ++T + ++V++ EK +S+ G + +G LP Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEK---FGLGLSYTYKDAGGTAYDKFGTP--LP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTP- 138 +T++ + + G + + + LR+ L LY LRPV+ Sbjct: 57 DDTIEACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVE 116 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K + D+VI RE IY G + +++ + Sbjct: 117 YSPLKPELVKGVDLVIVRELIGGIYFGDKCESEQHNGA-------------------ERA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 ++ S R+ + A E A R VT V K N++ T ++ ++A Sbjct: 158 WDLENYSVPEVDRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESY--- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + ++ D Q+ +RP ++DVI NL GD +SD A Sbjct: 213 -----------------PDVELNNLYVDNCAMQLAIRPTQFDVIVTGNLFGDILSDEAAV 255 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAAD 374 G IG+ P A+IG +L+E HG+AP AG+ NP ILSA M+LR+ + AA Sbjct: 256 VGGSIGMMPSASIGTSTSLYEPIHGSAPDIAGKGIANPMGTILSAAMLLRYSLHEEAAAK 315 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I ++ A+ T D + +G + E I E + Sbjct: 316 AIEAAVDKALADGYRTPDLWK--EGFQKANTEEITKVICERI 355 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 100/399 (25%), Positives = 167/399 (41%), Gaps = 69/399 (17%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + GDG+G ++ + +V I + E+ ++S Sbjct: 62 KACYGGRHTVAMLLGDGVGPELLSYVKEVFQVI-------GAPIDFEEVAVNQESEDATF 114 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + L ++ V IKG T G S NVALR L+LY ++ R + G Sbjct: 115 T------DALLAMKRNGVGIKGNFAT--EPGQSSRNVALRLNLNLYAFVQRCRNFPGV-- 164 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V + D+VI REN+E Y+ +E + E +K Sbjct: 165 -VTRHQNVDIVIIRENTEGEYSRLEHENVPGVVE-----------------------SLK 200 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + E + R+ + A +YA+ ++R VT VHK NIMK +G F D +A+ Sbjct: 201 IITREKSTRIAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY------- 253 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I +I D Q++ +P ++DVI NL G+ + + A VGG Sbjct: 254 -------------PQIEFNHMIIDNTCMQLVTKPQQFDVIVLPNLYGNIVGNVAAGLVGG 300 Query: 320 IGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ G N+G + ALFE T + AG++ NP ++L++ ML ++G + A LI Sbjct: 301 AGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGMLLTSADMLEYLGHIKEAKLIRD 360 Query: 379 GMEGAI-NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I K T D K S+ +A+++++ Sbjct: 361 SVVDVIGEQKIRTADL------GGSFKTSKVIEAVLKSL 393 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 103/401 (25%), Positives = 158/401 (39%), Gaps = 61/401 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + I GDGIGVDVT +KV+D+A +I W E + G Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA------TGGRIEWTEFDYSCERYAKTG--A 52 Query: 83 WLPAETLDLIREYRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 +P + + + + G + P + L + LR+ + Y+ LRPVR G S Sbjct: 53 MMPPDAPTTLAGFDAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIAS 112 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+ E MVI REN+E Y+ I GV + Sbjct: 113 PLAGVSDEALSMVIVRENTEGEYSPIG-------------------GVHNRGNQNEFALQ 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + G +R++R A E A + V K N + + + ++A E Sbjct: 154 ESVFTRIGCERIIRYAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEY----- 207 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + DA +++ PA DVI NL GD +SD AA Sbjct: 208 ---------------PQTPSVSMHVDALAARMVSDPASLDVIVASNLFGDILSDLAAAIT 252 Query: 318 GGIGIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+A NI E ++FE+ HG+AP AGQ NP + IL+ M+L H+ A+ Sbjct: 253 GGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQILAGAMLLDHLNEPATAN 312 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 I ++ ++ V R D + G AI E Sbjct: 313 KIRLAVDQVLSDGRV-----RTPDLGGTATTEQLGTAIAEA 348 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 107/399 (26%), Positives = 179/399 (44%), Gaps = 41/399 (10%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG +VT +KV++AA + G + Q L Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAG---SLFGFSLELTHYPYGAEHYLSTRQ--VL 56 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P L+ + + G + P G R + + LR D Y +RPVR + TP P+ Sbjct: 57 PDHALEEMEGLDALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSF--TPGPL 114 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI----KFLREEMGVKKIRFPEHCGIG 197 + V+ REN+ED+Y GI D A + ++ + P+ + Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQY----- 226 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + ++ DA +++ P ++ VI C N+ GD +SD LA Sbjct: 227 ---------------ESVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIG 271 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+G+AP N+GD ++FE HG+AP AGQD+ NP + ILS M+LRH+G T AA + Sbjct: 272 GGMGLAPSGNVGDRLSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETSAAKAME 331 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ ++ E ++ L GDA++ + Sbjct: 332 DAVQRYLSG----PVEELPIEMGGRLGTRGAGDAVVRRL 366 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 135/393 (34%), Positives = 199/393 (50%), Gaps = 34/393 (8%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDG G ++ A V+D A + W G+ + + G+ L Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAA---GSAGFHLDWDVRPAGQGALRSVGE--LL 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 PA TLD IR VA+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + Sbjct: 57 PASTLDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAV---D 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+Y+G+E+ ADS A V L E +KP + Sbjct: 114 SGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHA-----DPGIAFSLKPITPG 168 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G++R+V A+++A N R V + TEG F + +L E Sbjct: 169 GSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEY------------ 216 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 +IV V ++ PA+ DV+ NL GD ISD AA VGG+G+AP Sbjct: 217 --------PDIVTATVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAP 268 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 GANIGD A+FEATHG+AP++AG +++NP ++ILS M+L H+G A I + + Sbjct: 269 GANIGDRTAVFEATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRSVL 328 Query: 385 NAKT-VTYDFERLMDGAKLLKCSEFGDAIIENM 416 VT+D A+ + + + +A+IE + Sbjct: 329 EEGRSVTFDLLPPDRAARAVTTTAYAEAVIERL 361 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 96/400 (24%), Positives = 176/400 (44%), Gaps = 60/400 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I IEGDGIG +V +K +++ + + + S+ + G K+ + +G +P Sbjct: 2 KKNIVVIEGDGIGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-P 138 ET+D + + G + P + LR+E+DLY +RP+ Y G Sbjct: 57 KETIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINK 116 Query: 139 SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP+K E + VI+RE + IY G + ++ + Sbjct: 117 SPIKERKLEGVNFVIYRELTGGIYFGKKGRSKNGK----------------------EAY 154 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 SE+ +R+ + + A + +R +TLV K N+++ T +++ ++A + Sbjct: 155 DYCVYSEKEIERIGEMSFKAARSRNRK-MTLVDKANVLE-TSRLWREVIQKMALDYS--- 209 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ ++ + D QIL+ P ++DVI N+ GD +SD + Sbjct: 210 -----------------DVDLEFLYIDNAAMQILINPRKFDVILTDNMFGDILSDEASIL 252 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 +G+ P A+IG + +LFE HG+ P+ G++ NP ILS MML + + +L+ Sbjct: 253 TSSLGLLPSASIGSKKSLFEPIHGSYPQAKGKNIANPLGCILSVSMMLEYFEMPQEKNLL 312 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + ++ +I K T D ++D E GD I + + Sbjct: 313 EEAVKSSIQEKICTPDI--ILDDRNSSSTEEVGDYIEKYI 350 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 100/400 (25%), Positives = 175/400 (43%), Gaps = 41/400 (10%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + +P I GDGIG +V KV+ AA E + W+++ G+ + Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQE---VYNFDVEWIDMPFSADHYVKTGE--TIS 57 Query: 86 AETLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +L + +YR G + G + + + +R D Y+ LRPV+ +G +P+ Sbjct: 58 ESSLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPL 117 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCG 195 K D + REN+ED Y GI ++ +++ ++ +R+ + G+ + Sbjct: 118 KGKTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIA 177 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + S+EG KR++ + + A + + ++ V K N++ G +++ A + Sbjct: 178 YQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKY--- 234 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ DA + P +DV+ N+ GD I+D A Sbjct: 235 -----------------PDVKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAM 277 Query: 316 QVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 GG+G+APG NI E ++FE G+APKY G +KVNP + I + M+L H+G +AA Sbjct: 278 IQGGLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGEKQAAA 337 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 IV +E + K + R D S+ G I Sbjct: 338 GIVDAIEQNLKEKKI-----RTYDLGGSAGTSDVGTDIAR 372 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 110/411 (26%), Positives = 165/411 (40%), Gaps = 78/411 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V PA + V+ A + G + Q G+ LP+ Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALPS 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 TL R + G + +P G RS V LR+ELDLY +RPV Sbjct: 57 ATLTAARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRR 116 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 D+V+ REN+ED+YAG E D I + + Sbjct: 117 RKVDLVVVRENTEDVYAGRERVEDDGA----------------------TAIAERVITRR 154 Query: 205 GTKRLVRAAIEYAIAN---------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + R++R A + A A VT+VHK N+++ T G F+ ++A+ Sbjct: 155 ASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAY--- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ I +++ D Q+ RP +DVI NL GD +SD A Sbjct: 212 -----------------PDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACA 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD- 374 GG+G+AP AN+G+ ALFE HG AP AG+ NP + I ++L H+ AD Sbjct: 255 WGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADL 314 Query: 375 ---------LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + + A T D ++ +A++ +M Sbjct: 315 ASAMRGWSARIQRAIRHVRAAGPHTPDL------GGSAVTTDITNAVLSHM 359 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 332 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 97/398 (24%), Positives = 176/398 (44%), Gaps = 65/398 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDG+G ++T ++ + +A I W I + + + Sbjct: 23 KKYGGRFTVTLIPGDGVGKEITDSVRTIFEA-------ENIPIDWETINIKQTD---HKE 72 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 V+ E ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + Sbjct: 73 GVY---EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT 129 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 + D+++ REN+E ++G+E ++ E +K Sbjct: 130 RI---PDIDLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLK 163 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 164 VMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY------ 217 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q + +P ++DV+ ++ G + + AA +GG Sbjct: 218 -------------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 G+ GAN G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K Sbjct: 265 PGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISK 324 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I T D ++F + II + Sbjct: 325 AVHETIAEGKHT-----TRDIGGSSSTTDFTNEIINKL 357 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 84/397 (21%), Positives = 151/397 (38%), Gaps = 64/397 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDG+G +V + +V+ + Y G + + GQ LP Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVE---RLYGHHFHLQDEYFGGVAIDLTGQP--LPQR 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTP--SPV 141 TL + G + P + +ALR+ L ++ +RPV T SP+ Sbjct: 59 TLAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPL 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 K+ + D V+ RE + IY + E Sbjct: 119 KNADEIDFVVVRELTGGIYFSYPKER-----------------------TEEVATDTLTY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +R+V A + A + VT + K N+++ + ++ ++A Sbjct: 156 HRHEIERIVSYAFQLANKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRY--------- 204 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 + ++ ++ DA +++ P +DVI NL GD +SD + G +G Sbjct: 205 -----------PNVEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLG 253 Query: 322 IAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKG 379 + P A+ ++ +L+E HG+AP AG++K NP +++ S MML G T I + Sbjct: 254 MLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEEA 313 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D + F A+I+ M Sbjct: 314 VSAVLKSGKCTADI------GGTETTTSFTKAVIQEM 344 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 330 bits (846), Expect = 7e-89, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 152/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 ++ I I GDGIG DVT A +V+ + ++ + G + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHS---GFTLTATPFPWSCAFYKETG--AMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PPDGIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + A + + Sbjct: 117 LK-AEGFDILCIRENTEGEYSGAGGRVHQGTA-------------------DEVAVETSI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R + A R + V K N K++ + + +LA E Sbjct: 157 FTRTGVERILRFGFDQARQRRRK-LASVTKSNAQKYSMVLWDEITRELAAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+ NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVVASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G AA ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLDHLGQARAARKVI 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + +E T + A++ + Sbjct: 316 EALERTTARGIGTVP--------GKNRTETITAAVLAAL 346 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 330 bits (846), Expect = 7e-89, Method: Composition-based stats. Identities = 95/395 (24%), Positives = 157/395 (39%), Gaps = 56/395 (14%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +V A + + AA+E ++ G + G +P + Sbjct: 9 RLAVIPGDGIGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAMPPD 63 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 DL+++ + G + P L + LRQ+LDL + LRPVR + G P+ V+ Sbjct: 64 AADLVKKTDAVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E Y G GV GI + S Sbjct: 124 DGVDLVIVRENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRR 164 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 +R A A + LV K N M++ + ++ + Sbjct: 165 AIERAAHQAFALAGRRS-GRLCLVTKSNAMRYGYPLWDRVVREVGEQY------------ 211 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++ V+ DA +++ P DV+ NL GD +SD A GG+G+AP Sbjct: 212 --------PGVELETVLVDAMAARMIQAPRSLDVLLASNLFGDILSDLAAVLAGGMGMAP 263 Query: 325 GANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 AN+ + ++E HG+AP AG+ NP + +LS M+L +G T+AA + + Sbjct: 264 SANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLLSGAMLLEDLGHTDAARRVRDAVA 323 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D ++ A++ M Sbjct: 324 DTLRDTRH-----HTADLGGNATTADVASAVLHTM 353 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 330 bits (845), Expect = 7e-89, Method: Composition-based stats. Identities = 98/411 (23%), Positives = 171/411 (41%), Gaps = 66/411 (16%) Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67 PA+ K TL K + + + G GIG ++ + + G+ + + Sbjct: 30 PARCSKRTLHR-KSKIGGRFFVTLLPGHGIGPEMMRHVEAIF-------ACGKVPVDFET 81 Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPL-TTPVGGGIRSLNVALRQELDLYI 126 I G + + IR VA+KG + TT + N+ LR +L+LY+ Sbjct: 82 IIVDAN----VGDASSM-DHAIKSIRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYV 136 Query: 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 + R + G + + D+V+ R+N+E Y+ +E + S E Sbjct: 137 NVVHCRNHPGINT---KHKGVDIVVIRQNTEGEYSCLEHEVTSGVVE------------- 180 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 +K + + ++ + EYA + R VT+VHK NIMK T+G F Sbjct: 181 ----------SLKIITWAKSFQIAKYCFEYARTHMRKKVTVVHKANIMKLTDGLFLKTCT 230 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 ++A+E +I + D+I D Q++ PA++DV+ NL G Sbjct: 231 EVAQEY--------------------PDIELNDIIIDNCCMQLVANPAQFDVMLVPNLYG 270 Query: 307 DYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + + + VGG G+ G N G E A+FE AT T G++ NP + + +A ML+ Sbjct: 271 NIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVATLYAAVDMLK 330 Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+ + A +I + +E +N D D S+ + I++ + Sbjct: 331 HLELWDHAVVIRRAIEKTVNR-----DKVHTKDLGGDATTSKVVENILKEV 376 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 107/412 (25%), Positives = 169/412 (41%), Gaps = 73/412 (17%) Query: 19 GKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY 78 + + + +GDGIG ++ A + ++A I W ++ G ++ Q Sbjct: 26 QRAQSTQAHTVLTFDGDGIGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNT 78 Query: 79 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICL 128 G V++ +D E V KGPLT P S N R+ L+ + Sbjct: 79 G--VYIDDSHMDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANV 136 Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188 RPVR G +P D+V+ REN+ED+Y G E D Sbjct: 137 RPVRSMPGVRAPF---NDVDLVVIRENTEDVYTGEETWVD-------------------- 173 Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 +K S ++R+ + +YA N R VT +HK N+ K ++G F + ++ Sbjct: 174 ---ADTVHCVKRISRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHER 230 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A I+ D +AD+ L ++++ P +DV+ C NL GD Sbjct: 231 AA------------------ATDLGGIIADDQLADSCLTKLMIEPKSFDVLCCPNLYGDL 272 Query: 309 ISDALA----AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364 ++ VG +G+ P NIG ALFE HG+AP AG+ NP S ILS MML Sbjct: 273 VNPLSLRINRGMVGSLGLCPSGNIGTHQALFEPAHGSAPDIAGKGIANPTSQILSGCMML 332 Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G EA+ + + + V DF E A+++++ Sbjct: 333 SHLGEFEASQRLENALRAMYASGIVPVDF------GGQADTKEVVAAVLKHL 378 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 106/414 (25%), Positives = 171/414 (41%), Gaps = 70/414 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + P++ + + + GDGIG ++ + K+ + Sbjct: 30 IQSPSKNQFARYGG-------RHTVTLLPGDGIGPEMLDIVQKIF-------TFANVPVD 75 Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELD 123 + E K T + I+ VAIKG + T +S NV LR+ LD Sbjct: 76 FEECQLDSKPT----SPESDLDNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLD 131 Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 L+ + P+ + ++V+ REN+E Y+G E + + E Sbjct: 132 LFANVLHCVSIPTIPT---RHKGINIVMIRENTEGEYSGHEHETVNGVVE---------- 178 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 +K C+ E +R+ R A +YAIA++R +T VHK NI K +G F Sbjct: 179 -------------SLKICTREKLERISRFAFDYAIAHNRKKITAVHKANIQKLADGLFLK 225 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++A +E+ I +I D Q++ RP ++D++ N Sbjct: 226 VVGEIAEKEY-------------------PSITFDSMIVDNASMQLVSRPQQFDIMLMPN 266 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEM 362 L G+ IS+ VGG G+ G NIGD+ A+FE T T AGQD NP + I + Sbjct: 267 LYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTAFIRAGVD 326 Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ML ++G TE A+LI + AI K + D K S+ +A++ N+ Sbjct: 327 MLHYLGLTEYANLISDALFDAIVIKRL-----HTKDIGGTAKTSDVVNAVMRNI 375 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 108/416 (25%), Positives = 192/416 (46%), Gaps = 71/416 (17%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEK---AYKGERKISWMEIYTGEKS 74 N + + +I I DGIG +V PA ++V++AA+ K A + + + ++ + G ++ Sbjct: 23 NQQQIRLLSKVIGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWET 82 Query: 75 TQVYGQDVWLPAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPV 131 Q G+ LP ET++ ++ + AI G + +P G S VA+R+ +DLY +RP Sbjct: 83 FQKTGKS--LPVETVEALKNKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPC 140 Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 + + DM+I REN+E +Y E Sbjct: 141 QDL---------AKGIDMLIVRENTECLYIKKEKLTVDPT------------------TG 173 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDR---DSVTLVHKGNIMKFTEGAFKDWGYQL 248 E + + +E +KR+ A + A+ ++ VT+VHK N++ ++G F++ ++ Sbjct: 174 EKTAVADRLITERASKRIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEI 233 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 +++ ++ ++ + D+ + +++L P +YDV+ NL GD Sbjct: 234 SKKY--------------------PQVKTEEQLVDSMVYKMILDPTQYDVVVAPNLYGDI 273 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SDA +A VGG+G+ AN+ D AL E HG+AP G+ NP + I + M+LRH+ Sbjct: 274 LSDAGSAFVGGLGVTASANLSDSFALVEPVHGSAPDIFGKKISNPIATIRACAMLLRHLQ 333 Query: 369 W--------TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + KTVT D DAII+N+ Sbjct: 334 EKDPKCSYLNEIADSMDRAVNVVMPDKTVT-----TPDLGGKGNTETLVDAIIKNL 384 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 117/422 (27%), Positives = 186/422 (44%), Gaps = 61/422 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P + + GDGIG V P ++V++A +A I W + LP Sbjct: 3 RPTVVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECW---------CNEGNALP 53 Query: 86 AETLDLIREYRVAIKGPLTTPVGG---------------GIRSLNVALRQELDLYICLRP 130 T+ L+R++++ + G +T+ S V +RQ +L +C+RP Sbjct: 54 DRTIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRP 113 Query: 131 VRYYQGTPSPVKHP--------ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182 + G P D+V+FR+N+E +YAG+EW + + ++ Sbjct: 114 CLSFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKF 173 Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242 E + ++ +++ +R+ AA ++A +VT+ K N+++ T G + Sbjct: 174 AAFANT-PGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMME 232 Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302 + Q+ ++ EI + DA + P EY VI Sbjct: 233 EVAKQVQKQY--------------------PEIALWSTNIDAQTMWLTKNPEEYGVIVAS 272 Query: 303 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQD--KVNPGSIILSA 360 NL GD ISDA A VGG+G A NIGDE A+FE THG+APKYA + VNP ++ILSA Sbjct: 273 NLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSA 332 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGA-----KLLKCSEFGDAIIE 414 MML H+G +E AD I K + + TYD R+ G + DAI+ Sbjct: 333 AMMLDHIGESEKADRIRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILV 392 Query: 415 NM 416 ++ Sbjct: 393 HV 394 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 93/398 (23%), Positives = 167/398 (41%), Gaps = 69/398 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + V+ I + I ++S+ Sbjct: 82 SQYGGRYTVTLIPGDGIGPEMARHVKTVLHKC-------GAPIDFEVIDIKDESS----- 129 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ++ + +KG +TT +S+N +R++LDLY + P + G Sbjct: 130 ----TDAAIISLKRNGIGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGV-- 183 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+V+ REN+E Y +E + E +K Sbjct: 184 -WTRHGQVDLVVIRENTEGEYGSLEHENVDGVVE-----------------------SLK 219 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 +E+ ++R+ + A +YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 220 IITEKKSRRIAKFAFDYALQNNRRKVTAIHKANIMKLADGLFLETCREISKDY------- 272 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 +I + +I D Q++ P ++DV+ NL G+ +S VGG Sbjct: 273 -------------TDIEFESMIIDNCCMQMVTNPQQFDVMVMPNLYGNIVSHIGIGLVGG 319 Query: 320 IGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 IG+ PG NIGD+ A+FE+ G ++ NP + ++ +MLRH+G + AD+I Sbjct: 320 IGLVPGKNIGDKYAIFESGARNIGSDLVGLNRANPCGFLFTSALMLRHLGLDDYADIIES 379 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + I R D ++F DA+I+ + Sbjct: 380 AVRTTIKNGKC-----RTPDIQGDRTTADFIDAVIKEI 412 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 328 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 89/401 (22%), Positives = 161/401 (40%), Gaps = 66/401 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG ++ L +++ K Y +I E G S +G+ L Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPS-- 139 +TL+ + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 EKTLNACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLS 116 Query: 140 PVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G ++ + + Sbjct: 117 PLKAERVEGTDLVIVRELTSGIYFGEPRYFNNHE-----------------------ALD 153 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + E +R+V A + A + R +T V K N++ + ++ ++ Sbjct: 154 SLTYTREEIERIVHVAFKLAASR-RGKLTSVDKENVL-ASSKLWRKVVNEV--------- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ P ++DVI NL GD +SD + Sbjct: 203 -----------SQLYPEVTVNHLLVDACSMHLITNPKQFDVIVYENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ ++ L+E HG+AP AG++ NP +ILS M LR + +AAD Sbjct: 252 GSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSLAMCLRESLNQPDAADE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + I T D L ++ + + + + Sbjct: 312 LEQHIYNMIEHGQTTADL------GGKLNTTDIFEILSQKL 346 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 101/393 (25%), Positives = 164/393 (41%), Gaps = 63/393 (16%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDG+G +V K +DA E I+W ++ G +G +PA+ Sbjct: 3 VVLLPGDGVGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADA 53 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KH 143 +D++R + + G + P + L + +RQELDL++ +RP R +G P P+ + Sbjct: 54 IDVLRGHDAILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRA 113 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 P DMV RENSE YAG+ + F I + Sbjct: 114 PHDVDMVFVRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFTR 154 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +R++R A A A + + K N +F + + ++ E Sbjct: 155 RGCERVIRYAFGMASAR-KGVLVNATKSNASRFGFPFWDEIVAEVGAEF----------- 202 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 +V+ ++ DA +++ P DV+ NL GD ++D AA GG+G+A Sbjct: 203 ---------PGVVVDRMLVDALSARLIRDPGSVDVVVASNLFGDILTDIAAALQGGMGMA 253 Query: 324 PGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 AN+ ALFE HG+AP AG+ NP I SA +ML +G E + ++ + Sbjct: 254 ASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSAALMLEQLGAGEGSRRLMDAL 313 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E T D +E GDA++ Sbjct: 314 ETVCRRGPRTRDV------GGTATTAEVGDAVV 340 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 102/409 (24%), Positives = 165/409 (40%), Gaps = 68/409 (16%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V PA L++V+AA A G + G L Sbjct: 6 DTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHN--AGAQYYAESGD--AL 61 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA TLD R+ + G + P G + LR EL L+ +RP+R++ G P Sbjct: 62 PASTLDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 141 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + P E D V+ RE +E ++ + Sbjct: 122 LTDPRAEQIDFVLVREQTEGLFYARGRGEIR---------------------NDEEAYDT 160 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + GT+R+ A + A R +VT V K N+ + + F+ ++A Sbjct: 161 MQITRSGTQRVTEFAFDIARQRKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRHS- 218 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ DA ++ +P +DV+ N+ GD +SD A Sbjct: 219 -------------------DLTKDHAYVDALALNMVKKPWTFDVLVTENMFGDILSDLAA 259 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG------ 368 +GG+G+AP A+IGD+ LF+ HGTAP AG+ NP ++ LSA MML + Sbjct: 260 GLIGGMGMAPSADIGDKHGLFQPAHGTAPDIAGKGCANPSAMFLSAAMMLDWLAAKFGQP 319 Query: 369 -WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA L+ +E ++ K M+ C+E ++I ++ Sbjct: 320 TLADAARLMEGAVEHTLSTK-----LAIPMEYGGNANCAEMTRSVISSL 363 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 326 bits (836), Expect = 9e-88, Method: Composition-based stats. Identities = 105/397 (26%), Positives = 170/397 (42%), Gaps = 62/397 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I I GDGIGV+V K+ + I + G + G+ V P Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGKVV--P 60 Query: 86 AETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 + +D +++Y + G L P + +RQ+LD ++CLRP +++ G P+P+K Sbjct: 61 IDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLK 120 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+++ RENSE Y+ I G+ K P+ I + Sbjct: 121 KCE-IDILVVRENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHT 160 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G +R++R A E + R+ VTL K N MK+ + +A E Sbjct: 161 RRGLERVIRYAFEASRKR-RNHVTLATKSNAMKYGMVLWDSVFEAIAMEY---------- 209 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 ++ + DA +I+ P+++DVI NL D ISD G +GI Sbjct: 210 ----------PDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDIISDLTVTVAGSMGI 259 Query: 323 APGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 AP ANI E +LFE HG+A AG+ +P + ++ MML +G++E + LI + Sbjct: 260 APSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASSMMLEFLGYSEESVLIEEA 319 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ +I K T D +E G+ I + + Sbjct: 320 IQSSILQKITTIDI------GGTKTTNEVGNFIADYI 350 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 161/405 (39%), Gaps = 57/405 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG++V A L V+ A + G + + G+ V P Sbjct: 7 RKRICVLPGDGIGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGETV--P 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR---------------SLNVALRQELDLYICLRP 130 A T +++ + G +T+ S + LRQ LDLY +RP Sbjct: 58 ARTWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRP 117 Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 V G V+ REN+E +YAG+++ +++ + Sbjct: 118 VTDMTG-------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + + ++ + G R+ A EYA N VT V K +++ + + A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ DA ++ RP + VI N+ GD +S Sbjct: 231 RY--------------------PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILS 270 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370 D A +GG+G AP N G+ A FE HG+AP +AG +K NPG++ ++ +ML H+G+ Sbjct: 271 DLGAGVMGGLGFAPSGNFGNSGAYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFP 330 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + I + + T TYD ++ G+AI++ Sbjct: 331 TESACISQAVSLVSRTSTRTYDL------GGSHTTAQVGEAIVQQ 369 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 96/397 (24%), Positives = 167/397 (42%), Gaps = 62/397 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I DGIG + +++V + + E Y + + + Sbjct: 40 ATYGGRHTVSLIPADGIGQSLIMGIVEVFQ-------NSGVPVDFEECYITGDTNEEKMK 92 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + + A+KG T +G +S NV LR +LDLY + + Y + Sbjct: 93 SF---NDIKTSVLRNGTALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSYP---TV 146 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+++ REN+E Y +E + E IK Sbjct: 147 ITRHNNVDLIVIRENTEGEYTNLEHENIPGVIEM-----------------------IKI 183 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +++ ++R+ + A +YA+ N+R VT VHK NIMK ++G F ++A Sbjct: 184 ITKKKSERIAKYAFDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGY-------- 235 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 EI D+I D Q++ +P ++DVI NL G+ +S+ AA VGG Sbjct: 236 ------------PEIDFNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAALVGGP 283 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ G N G+ +FE+ T + A ++ NP S++ +A +LRH+ ++ A LI Sbjct: 284 GLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSMLFAATALLRHLQLSKHAQLIESC 343 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + K VT + R +D SEF + +++ + Sbjct: 344 I-----HKIVTTNQARTVDIGGNTSTSEFFEILVKEV 375 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 86/408 (21%), Positives = 153/408 (37%), Gaps = 62/408 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + N I + GDGIG + T + K+++ + + + I E G + G Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKK---QFQINIVTTEHKIGGDAINSEGTP- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQ 135 P TL + + G + P ++ +ALR+ +L+ LRP+ Sbjct: 57 -FPKSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLAD 115 Query: 136 GTP--SPVKH---PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190 SP+ P D++ RE + IY G Sbjct: 116 ELKELSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGL------------------ 157 Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 +R+ A + A R V+ + K N++ T +++ LA+ Sbjct: 158 -NEYAFDTAVYHRFEIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAK 214 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 ++ ++ + D Q++ P+++D+I C NL GD +S Sbjct: 215 NY--------------------PDVELEHLYIDNASMQLINNPSKFDIILCPNLFGDILS 254 Query: 311 DALAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MG 368 D A G IG+ P A+I + L+E G+AP A ++ NP + ILS ++ R+ + Sbjct: 255 DECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIAHILSIALLFRYSLK 314 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A I K + A+ T D + + K + +E GD I + Sbjct: 315 LDHIAIKIEKAVSQALMLGYRTIDIAKKHE--KSISTNEMGDIIAALI 360 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 323 bits (829), Expect = 6e-87, Method: Composition-based stats. Identities = 105/403 (26%), Positives = 174/403 (43%), Gaps = 61/403 (15%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + + + GDGIG ++ PA +K++D A G I+W E+ G + YG+ Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILD--AAVAAAGATPIAWTELPLGRSAIDEYGEHT- 77 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPS 139 P +TLD + E + GP + + + +R+ L+ +RP + ++G + Sbjct: 78 -PTKTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNA 136 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 V E TD+VI REN+E YA A + + + I Sbjct: 137 IV---EGTDLVIVRENTEGFYADRNTFAGTGE----------------MMPTPDVAIMHG 177 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + T+R+ A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 178 IITRAATERIAHEAFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQY------- 229 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ I D DA ++ R ++DVI N+ GD +SD G Sbjct: 230 -------------PDVAINDFHIDAATVHLVRRADKFDVIVTENMFGDILSDLAGEVAGS 276 Query: 320 IGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT-------EA 372 +GIAP N A+ +A+HG+AP AG+D NP ++ILS+ M+LR + A Sbjct: 277 LGIAPSINSSATHAMAQASHGSAPDIAGRDIANPIAMILSSAMLLRWLAAKFDDEKIARA 336 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD++ ++ + T D CS F DA++ Sbjct: 337 ADIVEAAVDLTVAEGATTPDM------GGTSSCSGFADAVVAA 373 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 323 bits (827), Expect = 1e-86, Method: Composition-based stats. Identities = 100/409 (24%), Positives = 161/409 (39%), Gaps = 63/409 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V + KV+ E G S +G + Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLN---SNKSLDFEIDEDLAGGCSYDKHGTP--I 59 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQG-T 137 E E + G + P + R +EL L+ LRP ++ Sbjct: 60 TDEVFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLV 119 Query: 138 PSPVKHPE---LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 + PE D++I RE + IY G E G+K I E Sbjct: 120 DASTLKPEIVSGLDIMIVRELTGGIYFG------------------EPRGIKPIENGERK 161 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 GI + R+ + A + A + VT K N+M+ + +K+ +L +E+ Sbjct: 162 GINTHSYTTSEIVRVAKVAFDLARKRS-NRVTSCEKSNVMEAGQ-LWKEEVQELHDKEYK 219 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ + ++AD Q+L P ++DVI NL GD +SD + Sbjct: 220 -------------------DVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQAS 260 Query: 315 AQVGGIGIAPGANIGDEC------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++G + A++E HG+AP AG++ NP + ILS M LR+ + Sbjct: 261 MLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSL 320 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + K ++ +N T D G K + S GDAII + Sbjct: 321 DLDSEADALEKAVQDVLNDGLRTKDILSQ--GKKEVSTSAMGDAIISKL 367 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 89/406 (21%), Positives = 153/406 (37%), Gaps = 64/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + + KV+ E G + +GQ + Sbjct: 5 KLLLLPGDGIGPEAMAEVRKVI---AFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDA 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ + G + P + + + LR+++ LY LRP Y Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 142 KHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 E D++I RE + +Y G + + + GI Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIID------------------LGNGQKRGID 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ A E A R+ VT + K N+MK Sbjct: 162 TQVYDTYEIERIADVAFELARTR-RNKVTSMEKRNVMK--------------------SG 200 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 + + ++ ++ ++ ++ADA Q++ P ++DVI NL GD +SD A Sbjct: 201 VLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFDVILTDNLFGDLLSDVAAMLT 260 Query: 318 GGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGW 369 G +G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ G Sbjct: 261 GSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASLAMCLRYSFGL 320 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + + G ++ T D +G + +E GDAI+ Sbjct: 321 VAEADRLEAAIAGVLDDGIRTADI--WSEGNTKVGTTEMGDAILAK 364 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 169/401 (42%), Gaps = 55/401 (13%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P++ + + GDGIG +V +++++ E ++ + GE Q G+ Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE--YQRSGE-- 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 LP D + G + P G + + LR+ L LY +RP+R Y Sbjct: 57 ALPQSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEAD 116 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 +P+K P D V+ RE++E ++ G + AD Sbjct: 117 TPLKGHGPGEIDFVLVRESTEGLFYGRDAIAD---------------------LEADEAT 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + ++R+ R A E A + +VTL+ K N++ + F+ ++A+E Sbjct: 156 NLLRITRSASERVCRLAFETARRRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFL-- 212 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 +I + V DA ++ RP ++DV+ N+ GD +SD A Sbjct: 213 ------------------DIKAEHVYVDAAALFLVRRPQDFDVMVTENMFGDILSDLAAG 254 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+AP +IGD+ A+F+ +HG+AP AGQ NP ++ LS MML + E Sbjct: 255 LVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMMLEWLDHPET--R 312 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A A ++ +R D L E D I E + Sbjct: 313 RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAERL 353 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 172/402 (42%), Gaps = 60/402 (14%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 N +EGDGIG ++ A + V+ AA++ + K++ + G S + + Sbjct: 3 NLKFLVLEGDGIGPEIAKASVDVLQAALK---LYDLKVNLVYEEIGFASLKKH--KTTFR 57 Query: 86 AETLDLIREYRVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 +E L + + I G + P G + + +R+ DLY +RP + G Sbjct: 58 SEVLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF 117 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 P D ++ REN+E Y+ GV ++ I I+ Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNM----------------FKGVGELMPTPDVAISIRNI 159 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + +G+ R+ +YA+ R + +HK N++++++G F + Q++++ Sbjct: 160 TRKGSTRIAEIGFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKY--------- 209 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 E+ K+ I D+ ++ P+ +DVI NL GD +SDA + GG+G Sbjct: 210 -----------PEVEYKEQIVDSMSAMLIRDPSVFDVILATNLFGDNLSDAASEIAGGLG 258 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-------WTEAAD 374 +A N G+ + +A HG+AP AG++ NP S+I S MML +G E A Sbjct: 259 LAESINAGENYCIAQAQHGSAPDIAGKNIANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQ 318 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +I ++ I R D L ++F D +I N+ Sbjct: 319 MIEDAIDKTIIN-----PKTRTSDIGGNLSTTDFTDVLISNL 355 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 87/399 (21%), Positives = 153/399 (38%), Gaps = 61/399 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG DVT A V++ + A G + G + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENG--SMM 56 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 PA+ ++ ++ + + G + P + L + +R+ Y +RP R G P Sbjct: 57 PADGIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 ++ + D++ REN+E Y+G + I Sbjct: 117 LRS-DGFDILCIRENTEGEYSGAGGRIHQG-------------------ADNEVAIETAI 156 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +G +R++R E A A R + V K N K++ + + + L+ E Sbjct: 157 FTRKGVERILRFGFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEY-------- 207 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + DA ++++ P DV+A NL GD ++D AA GG+ Sbjct: 208 ------------PDVEVTSYHIDAMAARMVMAPESLDVVAASNLFGDILTDLGAAIQGGL 255 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP A NP + I S MML H+G T AA+ ++ Sbjct: 256 GFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAIWSGAMMLEHLGETAAAEKVM 315 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +E + +++ + Sbjct: 316 DAIETTTARGV--------GAIPGKDRTDAITASVLSAL 346 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 87/362 (24%), Positives = 151/362 (41%), Gaps = 54/362 (14%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + I GDGIGVDVT A ++V+ AA + G + +G+ + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAAK----GRFAFDTTSFPWSCEYYLEHGR--MM 55 Query: 85 PAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 P + ++ +R + G + P + L + +R+ + Y +RP R G P Sbjct: 56 PEDGIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGP 115 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +K E D++ REN+E Y+G + + Sbjct: 116 LK-AEGFDILCIRENTEGEYSGAGGRVHEGK-------------------GNEVAVETSV 155 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + G +R++R E A + R +T V K N K++ + + +LA E Sbjct: 156 FTRAGVERILRFGFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEY-------- 206 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + + DA ++++ P + DV+ NL GD ++D AA GG+ Sbjct: 207 ------------PDVTVSHMHIDAMAAKMVMAPQDLDVVVASNLFGDILTDLGAAIQGGL 254 Query: 321 GIAPGANIGDE---CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G A ANI + ++FE HG+AP AG++ NP + I S ML H+G E + ++ Sbjct: 255 GFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAIWSVAQMLDHLGEAEVSAAVL 314 Query: 378 KG 379 Sbjct: 315 SA 316 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 317 bits (813), Expect = 5e-85, Method: Composition-based stats. Identities = 98/411 (23%), Positives = 161/411 (39%), Gaps = 62/411 (15%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + I + GDGIG++VT A L V + I W + Sbjct: 1 MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAA------ 54 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLY 125 +P+ T LI + G +T+ S + LRQ LDL+ Sbjct: 55 ---IPSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLF 111 Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 +RP P + I RENSE +Y G ++ K I L E Sbjct: 112 ANVRPCFSIDDQSKP------FNFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQH 161 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 + + ++ S+ G RL A ++A+ VTL K N+++ + + Sbjct: 162 WQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIF 221 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLN 305 A+ +I + DA ++ P ++ VI N+ Sbjct: 222 ESTAQRY--------------------PKIQADILNVDAVALWLIKSPEKFGVIVAENMF 261 Query: 306 GDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 GD +SD A +GG+G+AP ANIGD+ + FE HG+ P+ ++ NP ++ L+ M+L Sbjct: 262 GDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRI-RKNCANPSAMFLTISMLLN 320 Query: 366 HMGWTEAADLIVKGMEGAINAKT-VTYDFERLMDGAKLLKCSEFGDAIIEN 415 H G+ + A IV + I K +TYD ++ +A+IE+ Sbjct: 321 HFGYPDRAKKIVNAVMQVIKEKRFITYDL------GGHATTTDMANAVIEH 365 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 316 bits (810), Expect = 9e-85, Method: Composition-based stats. Identities = 89/409 (21%), Positives = 162/409 (39%), Gaps = 64/409 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + GDGIG +V + +++D + G + V + Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIA---SFETEHGLVGGAAYDA--DKVAIT 57 Query: 86 AETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTP- 138 T+ L + I G + P + + LR++L L+ LRP Y Sbjct: 58 DATMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAE 117 Query: 139 -SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 S +K E D++I RE + +Y G + + Sbjct: 118 ASSLKPEVVEGLDIMIVRELTGGVYFGEPKTITD------------------LGNGQKRA 159 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 I + +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 160 IDTQVYDTYEIERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYK- 216 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ ++ +AD+ ++ P ++DVI NL GD +SD A Sbjct: 217 ------------------DVQLEHQLADSGGMNLVKWPKQFDVIVTDNLFGDMLSDIAAM 258 Query: 316 QVGGIGIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-M 367 G +G+ P A++ G A++E HG+AP AG+ NP +++ S M LR+ + Sbjct: 259 LTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGLANPVAMLASFGMALRYSL 318 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E AD + + + + T D + +G+ ++ S+ G+AI++ M Sbjct: 319 DMGELADKLDEAIAVVLARGLRTADIK--SEGSTVVSTSQMGEAIVQEM 365 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 110/398 (27%), Positives = 173/398 (43%), Gaps = 72/398 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I ++G+GIG ++T A ++V++A + W I +++ ++YG LP + Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQ 52 Query: 88 TLDLIREYRVAIKGPL-------------TTPVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I++ + IK PL T S+N A+R+EL+L++ RP+R Y Sbjct: 53 VIQRIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGY 112 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G E DMVI RE +ED Y G E + A Sbjct: 113 VGISG---RHEKMDMVIMREITEDTYIGWEKPLEDGAA---------------------- 147 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 IK + + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 148 AEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLY-- 205 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 +IV D++ DA ++ P +DV+ +N GD SD A Sbjct: 206 ------------------PDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDIFSDLAA 247 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+APGANIGD + FEA HG AP AG NP ++ILS +L H G+ + ++ Sbjct: 248 GLAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHAGYGKGSE 307 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAI 412 I + + I A D + DAI Sbjct: 308 AIREAVTRVIEAGR-----TLTPDLGGRSTTEQVADAI 340 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 158/400 (39%), Gaps = 66/400 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG ++ L+++ EK + + + G S YG L Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYH---FEYHLESHHFGGVSIDYYGTP--LT 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTP--S 139 ETL + + G + P + LR+ L+L+ +RP +G S Sbjct: 57 NETLQSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLS 116 Query: 140 PVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 P+K E TD+VI RE + IY G +A +K Sbjct: 117 PLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLK-------------------- 156 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S + +R+VR A A R +T V K N++ + ++ + ++ Sbjct: 157 ---YSSQEIERIVRIAFNLANRR-RKKLTSVDKENVL-SSSKLWRQIVNDVKKDY----- 206 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 E+ + ++ DA ++ +P ++DVI NL GD +SD + Sbjct: 207 ---------------PEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIP 251 Query: 318 GGIGIAPGANIGDECA-LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADL 375 G +G++P A+ G L+E HG+AP A +DK NP ++LS + LR + +AA+ Sbjct: 252 GSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANE 311 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + I + T D + SE + E Sbjct: 312 LESIVYSFIQSNKTTADL------GGQYRTSEIFKLLKEK 345 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 315 bits (808), Expect = 2e-84, Method: Composition-based stats. Identities = 100/390 (25%), Positives = 167/390 (42%), Gaps = 66/390 (16%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 P I I GDG+G ++ A++ V++ + + G+++ + G V LP Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSD---LMNLPLDLRFFEAGDETKRKRG--VALPE 56 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ETL+ + + + R + + LRQ+LDLY+ LRP + Y + Sbjct: 57 ETLNGVMNSDATLMVAIG----ESAREVILPLRQKLDLYVNLRPAKSYP----VPRAIPG 108 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+ I REN+ED+Y W+ + ++ + + Sbjct: 109 FDLTIVRENTEDLYVMSGWR------------------------GLDTAVDLRIITRRAS 144 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ R YA + V +VHK N++ F++ ++A EE Sbjct: 145 ERICRFGYRYARERGKSRVYVVHKANVLG-GCMLFREVCSRVAEEEGFD----------- 192 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 +++ D+ +I + +DVI N+ GD +SD AA +GG+G+ P A Sbjct: 193 ----------YREMYVDSAAMRIAMDRP-FDVIITTNMFGDILSDLAAAFIGGLGMYPSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 NIG+ A+FE HGTAP+ AG++ NP + ILSA MM+ +G + LI + + A Sbjct: 242 NIGESRAIFEPVHGTAPEIAGKNIANPMATILSAAMMMGWLGHEGGSKLIEEAVRRACEL 301 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D ++ E G I E M Sbjct: 302 GYTTPDV------GGSMRTKEVGLKISEIM 325 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 314 bits (804), Expect = 5e-84, Method: Composition-based stats. Identities = 77/402 (19%), Positives = 160/402 (39%), Gaps = 64/402 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I + GDGIG +++ ++V+ A EK K+++ G + G P Sbjct: 2 DFKIAVLAGDGIGPEISVQGVEVMSAVCEK---FGHKVNYEYAICGADAIDKVGDP--FP 56 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT- 137 ET + + + + P +A+R++L L+ +RPV+ ++ Sbjct: 57 EETYRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLV 116 Query: 138 -PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D + RE + +Y G +++ Sbjct: 117 HKSPLRAELVEGADFLCIRELTGGMYFGEKYQ------------------------DNDK 152 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 153 AYDTNMYTRPEIERILKVGFEYAMKR-RKHLTVVDKANVL-ASSRLWRQIAQEMAPQY-- 208 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 E+ + D +++ P +DV+ N GD ++D + Sbjct: 209 ------------------PEVTTDYMFVDNAAMKMIQEPKFFDVMVTENTFGDILTDEGS 250 Query: 315 AQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAAD 374 G +G+ P A+ G+ +FE HG+ P+ G + NP + ILS M+ + Sbjct: 251 VISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYFDCKAEGA 310 Query: 375 LIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 LI K ++ +++A T + + ++G + E G I++ + Sbjct: 311 LIRKAVDASLDANVRTPEIQ--VEGGEKFGTKEVGAWIVDYI 350 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 97/395 (24%), Positives = 154/395 (38%), Gaps = 48/395 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + DGIG ++ A ++V+ +A + +++ G S + YG L E Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSAD---SVFKLDLAFDYDDVGFTSLEKYG--TTLRDE 56 Query: 88 TLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L + Y I G G R+++ R LDLY +RP R S ++ Sbjct: 57 VLAKAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMRE 116 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI RE +E Y A+ + I ++ + Sbjct: 117 GRTMDLVIMREATEGFYPDRNMTKGWAE----------------LMPSPDMAISLRKITR 160 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 ++R+ R A E A+ + VT +HK N T+G F + +AR+ Sbjct: 161 HCSERIARRAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDF----------- 208 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 E+ + D++ DA ++ P +DV+ N GD ISD + G +G+A Sbjct: 209 ---------PEVRLDDLLIDASTAHLVRAPERFDVLVATNFYGDIISDLASELSGSLGLA 259 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA--ADLIVKGME 381 D +A HG+AP AGQDK NP S+ILS M+++ MG A L Sbjct: 260 GSMMASDTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQWMGEHHQNPAYLAAAQAM 319 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + R D C FG + + + Sbjct: 320 EAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKVI 354 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 88/390 (22%), Positives = 158/390 (40%), Gaps = 73/390 (18%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK-ISWMEIYTGEKSTQVYGQDVWLPAE 87 + I G GIG ++T ++ V +A ++ + Sbjct: 35 VTLIPGVGIGPEITNSVKTVFEALHVPIKFDVLDNFNFE------------------NDD 76 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + +R+ + G + T N + LDLY + +G + T Sbjct: 77 SKSQLRKNECILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNNT 131 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+V+ REN+E Y+G+E + E IK +++ + Sbjct: 132 DIVVIRENTEGEYSGVEHEVYPGVVE-----------------------SIKVTTKQASL 168 Query: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 R+ A E+A + R VT VHK NIMK +G F ++A+ Sbjct: 169 RIAEYAFEFAHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSF------------- 215 Query: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 I +++I D Q++ P ++DV+ NL G + + +A GG+G+A GA+ Sbjct: 216 -------IKYEEMIIDNCCMQLVKNPTQFDVMVMPNLYGSIVQNVVAGITGGVGMAAGAS 268 Query: 328 IGDECALF-EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA 386 IG + ALF + T AG++ VNP ++++S+ ++LRH+G AD I + ++ I Sbjct: 269 IGKDHALFSQGCRHTGRDIAGKNVVNPSAMLVSSTLLLRHLGLPNFADQICRAVQHTIQD 328 Query: 387 KTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K + + D +F +I ++ Sbjct: 329 KKI-----KTKDIGGNATTDQFTSEVIRSL 353 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 101/394 (25%), Positives = 166/394 (42%), Gaps = 71/394 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDG+G ++ A L +++ ++EI G+ G+ + Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLE--------RYIGADFIEIKAGKSYFIEEGKP--IEDN 51 Query: 88 TLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 ++ IRE +KGP+ TP G S+N LR+E LY +RP R Y+G Sbjct: 52 AIEKIRECDSLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISIR-----R 106 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D ++ REN E +Y G E + E I ++ ++ G Sbjct: 107 IDTILVRENLECLYYGWEVE------------------------DEDRAIAMRVITKRGA 142 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+ A A R VT +HK NI+K T+G F D Y++A + Sbjct: 143 ERISEFAFNLAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-------------- 188 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ D I DA +++ +DV+ NL GD +SD A VG IG+ A Sbjct: 189 -------DLRADDEIVDAAGYKLVKLDNAFDVMLTPNLYGDILSDVAAGVVGSIGLCGSA 241 Query: 327 NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW----TEAADLIVKGMEG 382 IG++ A FE HGT AG+ NP +I++A MML + + + I + ++ Sbjct: 242 QIGEDFAAFEPIHGTGEDIAGKGVANPIGMIIAASMMLDWLWERGRSPKRGEKIREAVDS 301 Query: 383 AINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + +T D + + + I++ + Sbjct: 302 VIRDRILTPDL------GGDFRTEQVVEKIVDRL 329 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 104/399 (26%), Positives = 166/399 (41%), Gaps = 60/399 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GD IG ++ P ++V+ AA + I W +I G + G LP Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAAR---TGLAIEWQDIPIGRAALDSLG--STLPDG 56 Query: 88 TLDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 T++ + + GP+ P + + LR+ DL+ +RPV+ + P Sbjct: 57 TIERLDALDGWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---H 113 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 + D+VI REN+E A S + R I ++ + Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGE----------------FRPTPDVTISVRVITRN 157 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G+ ++ RAA E A A R +T VHK + K G F + +LA E Sbjct: 158 GSSKVARAAFELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEY------------ 204 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + I D F ++++ P YDV+ N+ GD ++D A VGG+G+A Sbjct: 205 --------PDVTYDEAIVDTFAMRLVMTPQRYDVVVTTNMFGDILTDEAAGLVGGLGMAA 256 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLIV 377 G G A+ +ATHG+AP AG+ NP ++I+S +M+L +G AA LI Sbjct: 257 GLCAGPRHAMAQATHGSAPDIAGRGIANPYAMIMSGQMLLDWLGRRHAEPAATAAARLIE 316 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + I + D + G AIIE M Sbjct: 317 QAVANMIEERR-----ALTPDLGGQGTTAGMGSAIIEAM 350 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 87/403 (21%), Positives = 155/403 (38%), Gaps = 64/403 (15%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG + + K++ E G E G + +G + + Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAG---FVTDEGLVGGCAYDAHG--AAISEADMQ 62 Query: 91 LIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + G + P + + + LR++L L+ LRP Y S Sbjct: 63 KALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLK 122 Query: 145 ----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 E D++I RE + +Y G + + + GI + Sbjct: 123 PELVEGLDILIIRELTGGVYFGEPKEIID------------------LGNGQKRGIDTQV 164 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 +R+ A E A ++ V + K N+MK + + + + ++ Sbjct: 165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMK-SGVLWNQVVTETHKAKYS------ 216 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ ++ ++ADA Q++ +P ++DVI NL GD +SD A G + Sbjct: 217 -------------DVQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSL 263 Query: 321 GIAPGANI-------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 G+ P A++ G AL+E HG+AP AG+ NP ++I S M LR+ + Sbjct: 264 GMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNMVKE 323 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 AD + K + ++ T D DG + + E G+AI+ Sbjct: 324 ADDLEKAIANVLDKGIRTGDIM--ADGCRQVGTVEMGEAILAE 364 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 94/397 (23%), Positives = 167/397 (42%), Gaps = 64/397 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 V + + + GDG+G ++ A+ +V AA E +S ++ E+ Sbjct: 45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL------- 97 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 + L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G Sbjct: 98 ---EQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGY--- 151 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + D+VI RE +E Y+ +E ++ E +K Sbjct: 152 MTRHNNLDLVIIREQTEGEYSSLEHESARGVIE-----------------------CLKI 188 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + ++R+ + A +YA R VT VHK NIMK +G F ++A Sbjct: 189 VTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY-------- 240 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 +I + +I D Q++ P ++DV+ NL G+ I + A VGG Sbjct: 241 ------------PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGA 288 Query: 321 GIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKG 379 G+ PG + E A+FE + G++ NP +++LSA MLRH+ + +I Sbjct: 289 GVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348 Query: 380 MEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ++ I R D ++F ++I ++ Sbjct: 349 VKKVIKVGK-----VRTRDMGGYSTTTDFIKSVIGHL 380 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 87/419 (20%), Positives = 153/419 (36%), Gaps = 73/419 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD IG ++ +KV+ ++ + G S +G V Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIE--THRPNLHFNLTTDLVGGTSIDTHG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG----GGIRSLNVALRQELDLYICLRPV-RYYQGT 137 + LD + + G + P S + LRQ LD + LRP Sbjct: 57 PITQSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSL 116 Query: 138 --PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP++ + T ++ REN Y G + + E Sbjct: 117 VGASPIREHVVKGTRFIVVRENCGGAYFGEKKEE------------------------ED 152 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGY 246 + + +RL R + A R +V K N++ + ++ Sbjct: 153 VASDLWVYTRPEIERLARVSAAVARIMGRSEDDNQAATVWSADKANVL-ASGRLWRRITS 211 Query: 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLN 305 + +EF +I ++ +AD+ ++ P ++ VI N Sbjct: 212 DIFAKEF-------------------PDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTF 252 Query: 306 GDYISDALAAQVGGIGIAPGANIGD-------ECALFEATHGTAPKYAGQDKVNPGSIIL 358 GD +SD A G +G+ P A++ ++E HG+AP +G+ NP + IL Sbjct: 253 GDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQIL 312 Query: 359 SAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 S MMLR+ MG + A + + + ++AK+ R D CS+ GDA+ E + Sbjct: 313 SVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCEVL 371 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 310 bits (795), Expect = 5e-83, Method: Composition-based stats. Identities = 105/400 (26%), Positives = 165/400 (41%), Gaps = 61/400 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I GDGIG +V LKV+ A + + E G + G+ L Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPR---HGLTLDTTEYELGAQRWHATGE--VL 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P + +R++ + G + P R L + LR Y+ LRPVR Y G +P+ Sbjct: 59 PDAVEEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPL 118 Query: 142 KH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 PE DM++ RE +E YAG+ GV + P Sbjct: 119 AGVAPEDIDMLVVREGTEGPYAGMG-------------------GVLRKGTPHEIATQDS 159 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + G +R+VR A A +TLVHK N++ + ++ ++ E Sbjct: 160 VNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEY------- 212 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 ++ + + DA + +P +DV+ NL GD I+D AA GG Sbjct: 213 -------------PQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGG 259 Query: 320 IGIAPGANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376 IG+A NI GD ++FE HG+AP AGQ K +P + ILS +ML H+G+ +AA I Sbjct: 260 IGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGYADAAAQI 319 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + D + + ++ GD I + + Sbjct: 320 DQAVAE---------DLQERAKNGGVRSTTQIGDDIAQRV 350 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 310 bits (794), Expect = 6e-83, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 163/404 (40%), Gaps = 63/404 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + + GDGIG +V L+V+ AV + + + G GQ Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPA----DVSLDTTQYPFGAGHFLETGQ-- 54 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 L L + ++ + G + R L + LR D YI LRP Sbjct: 55 ILTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLP 114 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 G SP+ P D V+ RE +E YAG GV + Sbjct: 115 GVASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIA 155 Query: 196 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + + G +R VR A E A DR VTLVHK N++ F ++ ++A E Sbjct: 156 TEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAE---- 211 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 ++ + + DA + ++ P+ +DVI NL GD I+D AA Sbjct: 212 ----------------HPDVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAA 255 Query: 316 QVGGIGIAPGANIGDECA---LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 GGIG+A N+ A +FE HG+AP AGQ K +P + ILS ++L H+G +EA Sbjct: 256 ISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEA 315 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + + A T D +E GDAI+ + Sbjct: 316 AARVSAAVSDDLAA-RATGDAAPR-------STAEVGDAILRAL 351 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 309 bits (792), Expect = 1e-82, Method: Composition-based stats. Identities = 101/413 (24%), Positives = 159/413 (38%), Gaps = 74/413 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I + GDGIG +V+ A ++V+ A+ I + + G + + G Sbjct: 11 DGYRIAVVPGDGIGPEVSAATVRVLTQAL----GTSFPIEFRDYDAGAECFRRTG--TAF 64 Query: 85 PAETLDLIREYRVAIKGPLTTPV------GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 P T R+ + G P + ++ +R LDLY +RP+R +G P Sbjct: 65 PEATQVACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAP 124 Query: 139 SPV--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + K P+ I REN+E +YA Sbjct: 125 RRLVGKGPDDIRFTIVRENTEGLYAARGGGN---------------------IIRGQIAT 163 Query: 197 GIKPCSEEGTKRLVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 + EG +R+VR A E A A+ VT+V K N+++ + F++ + Sbjct: 164 DTLVMTREGVERIVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIADGVLA 222 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + I ++ VI DA ++ RP +DVI C NL GD +S Sbjct: 223 D--------------------CPGIEVEHVIVDAMTVHMIERPEHFDVIVCENLFGDILS 262 Query: 311 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG-- 368 D AA +GG+G+AP IG + F+ +HG+AP AG+ NP + ILS MML +G Sbjct: 263 DLGAAIMGGMGLAPSGEIGRDHGYFQGSHGSAPTIAGKGLANPIACILSGAMMLDWLGKR 322 Query: 369 -----WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T AA+ I + + A D I + Sbjct: 323 HSDPALTRAAERIREATGAVLKAGR-----AVTPDIGGSGSTESCAAEICATL 370 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 98/405 (24%), Positives = 159/405 (39%), Gaps = 78/405 (19%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 ++ + + GDGIG +V +++A E + + EI G + +G Sbjct: 6 AKDSYQVVLLPGDGIGPEVMAQARDLLEAVAEPS---GVRFELDEIPCGGRFYLEHGARD 62 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRP 130 W P + R V + G + P G S + R +LDLY +RP Sbjct: 63 W-PEDAEARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRP 121 Query: 131 VRYYQGTPSPVK-------HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 V+ G + PE DMVI REN+E +YAG+ + + V Sbjct: 122 VKLLPGVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASV-------- 173 Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKF 236 + + G +R++R A E R VT + K N+++ Sbjct: 174 -----------ATDTRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE- 221 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 F + ++A E +I + I DAF Q ++ +P Y Sbjct: 222 GCKLFAEVFAEVASEY--------------------PDIANELAIVDAFTQWLVTQPEHY 261 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSI 356 DV NL GD ++D + GG+G+A G N+GDE A+FE HG+AP AG+D+ NP ++ Sbjct: 262 DVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEHAMFEPIHGSAPPLAGKDEANPMAM 321 Query: 357 ILSAEMMLRHMGWTE-------AADLIVKGMEGAINAK-TVTYDF 393 +L+ L +G A + + + +T D Sbjct: 322 LLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVDL 366 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 106/391 (27%), Positives = 158/391 (40%), Gaps = 74/391 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDGIG +V ++V+ A + + + G Q G + Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR-------VRFEYYEGGVDVFQECGSP--IRE 52 Query: 87 ETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E L+ IR + G TTP G RSL + LR+EL LY LR + Sbjct: 53 EDLEEIRRSDAVLFGATTTPFDLPGYRSLILTLRKELGLYANLR---IIPDLRT------ 103 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 ++VI RENSE +Y GI + + ++ + EG Sbjct: 104 GREIVIVRENSEGLYFGIGAVVNG------------------------RAVDVRLITREG 139 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 +R+ R A+E A A +T VHK N++ + F+ ++A EE Sbjct: 140 AERIARFAVEQAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE------------- 184 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + ++D I D+F +++ P E+ VI NL GD +SD G IGI P Sbjct: 185 --------GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGSIGIVPS 236 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 N GD ALFE HG+AP AG+ NP ILS M+L ++G LI + G + Sbjct: 237 GNYGDGIALFEPVHGSAPDIAGKGIANPIGAILSGAMLLDYLGLD--GSLIRAAVRGYVV 294 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +T D + + II + Sbjct: 295 NGELTPDM------GGRARTEDVVRGIIGEI 319 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 305 bits (782), Expect = 2e-81, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 168/401 (41%), Gaps = 63/401 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ A ++V+DA E + R ++EI G + + G V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTG--VACAEA 61 Query: 88 TLDLIR-EYRVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 + +R E +KGP+ TP G L LR LD Y +RPVR + G PS V Sbjct: 62 DVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRV 121 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + D VI REN+E +YA Sbjct: 122 -RADRVDYVIVRENTEGLYASRGKGVG----------------------NRWAVTDTLLT 158 Query: 202 SEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 255 + EGT R+ R A A VT V K N+++ + F++ ++A E Sbjct: 159 TREGTLRVARKAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEF--- 214 Query: 256 ELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAA 315 E+ ++ ADA Q ++L P +DV+ N GD +SD A Sbjct: 215 -----------------PEVELEYRYADAAAQDLVLCPERFDVLVMENFLGDVLSDLGGA 257 Query: 316 QVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADL 375 VGG+G+ P N+GD A FE HG+AP G+++ NP +L+A M+L H+G + A Sbjct: 258 TVGGVGLCPAGNVGDGAAYFEPVHGSAPDLVGRNRANPVGQLLAAAMLLDHLGHVDEAAR 317 Query: 376 IVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + + TV + + + G DA+I + Sbjct: 318 LRRAVSAVLAFGTVRIEADGTVLGGA----EAVADAVIAAL 354 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 305 bits (782), Expect = 2e-81, Method: Composition-based stats. Identities = 109/393 (27%), Positives = 176/393 (44%), Gaps = 65/393 (16%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG--QDVW 83 + ++GDGIG +V +ML+V+ + + G + G + Sbjct: 2 SKKAAVMKGDGIGPEVVDSMLRVLKEC-------NFQSELILCEAGSEQWDKNGRKDASY 54 Query: 84 LPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 +P T+ ++ E KGP TT PV G RS+ V LRQ+ DLY +RP + Y + Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYD----RLT 110 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D V FRE +E +Y G+E + + I I+ + Sbjct: 111 PDRKLDCVCFREATEGLYTGVE-----------------------AKITDDAAIAIRKIT 147 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 +G++RL+ +A+++A + + V K NI+K T+G F Sbjct: 148 RQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGIF--------------------- 186 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGI 320 W + + G +I + ++ D QQ+++ +++ V+ NL D IS+ +A VG I Sbjct: 187 WDETQKAVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELASALVGSI 246 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ ANIGD A+FEA HG+AP++AGQ+KVNP + +LS M ++G + D I Sbjct: 247 GLIYSANIGDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMADYLGERDVRDAIFAAT 306 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 E IN D ++ DAII Sbjct: 307 EQVINEGK-----AVTWDIGGDASTTQMTDAII 334 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 305 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 95/412 (23%), Positives = 163/412 (39%), Gaps = 65/412 (15%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I ++ GDGIG +V + +V+D G + G + G + Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLN---QTGRTAFEVEDALVGGAAYDAQGTPL 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQ 135 +T+ L + G + P + LR++L+L+ LRP + Sbjct: 58 H--DDTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFD 115 Query: 136 GTPSPVKHP----ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 D++I RE + +Y G + G+ + Sbjct: 116 ALAEASTLKTELVSGLDVMIVRELTGGVYFG------------------QPRGISALPNG 157 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E G+ + R+ + A + A + V K N+M+ + +++ +L + Sbjct: 158 ERRGVNTQVYDTHEIVRVAKVAFDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGAD 215 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 EI + + AD Q++ +P ++DVI NL GD +SD Sbjct: 216 Y--------------------PEIALSHMYADNCAMQLVRQPKQFDVIVTDNLFGDILSD 255 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 A G +G+ P A++ G+ A++E HG+AP AGQDK NP + ILS MMLR Sbjct: 256 CAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDKANPLATILSFSMMLR 315 Query: 366 H-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E ADL+ + G + T D + G L+ + GDA++ M Sbjct: 316 YSFDLAEEADLVDNAVRGVLAKGLRTGDIFQP--GKTLVGTTGMGDALLAEM 365 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 305 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 97/399 (24%), Positives = 162/399 (40%), Gaps = 65/399 (16%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 K + + G GIG + + + I + + Sbjct: 50 KAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYI-------GAPIDFEVVDI-----DPTM 97 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTP 138 + + I+ V +KG + T S NVALR ELD+Y + + Y G Sbjct: 98 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 157 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + + D+VI R+N+E YA +E ++ + E + Sbjct: 158 T---RHKDIDVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SM 191 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 K + + ++R+ R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 192 KVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY------ 245 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 +I D+I D Q++ +P ++DV+ NL G +S+ + +G Sbjct: 246 --------------PDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLG 291 Query: 319 GIGIAPGANIGDECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G G+ G N GD A+FE T T AG++ NP ++I ++ ML H+G A L+ Sbjct: 292 GAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEHLGHQFHASLLR 351 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + IN D D ++ AI++N+ Sbjct: 352 RAINKTIN-----VDRVLTPDLGGSNTSTDVVGAILQNV 385 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 88/406 (21%), Positives = 164/406 (40%), Gaps = 63/406 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIGV+V + +++D K + + E G + V+G PAE Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPY--PAE 59 Query: 88 TLDLIREYRVAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-PSP 140 TL+ + G + P + + +R+++ L+ LRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 141 VKHPE---LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 E D++I RE + +Y G + G+ + G Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFG------------------QPRGIDTLPDGTRKGYN 161 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + +R+ R A + A + + V K N+++ T +++ +L +EEF Sbjct: 162 TLVYTTPEIQRIGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEF---- 215 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 ++ + + D Q++ P ++DV+ N+ GD +SD A Sbjct: 216 ---------------PDVELTHMYVDNAAMQLVRNPKQFDVMVTENMFGDILSDCAAMLT 260 Query: 318 GGIGIAPGANIGD------ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 G +G+ P A++G+ AL+E HG+AP AG+D NP + I+S M LR+ Sbjct: 261 GSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANPLATIMSFAMCLRYSFDMA 320 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 ADLI ++ + T D + G + + G+A++ + Sbjct: 321 AEADLIETAVKNVLKGGLRTADIMQP--GKAKVSTTVMGEAVVREL 364 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 85/412 (20%), Positives = 155/412 (37%), Gaps = 71/412 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + I + GD +G ++T +KV+ A + + K + G + G V Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--V 56 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVR-----Y 133 LP E L+ ++ + G + P G + +R+EL LY LRP Sbjct: 57 PLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSL 116 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 +P + + TD V+ RE IY G + D + Sbjct: 117 LDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDG----------------------DG 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R+ R A A+ ++ + + K N++ + ++ + + E Sbjct: 155 VAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVL-ASSRLWRKTVEETIKNE 213 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISD 311 F + ++ + D+ ++ P + +I N+ GD ISD Sbjct: 214 F-------------------PTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISD 254 Query: 312 ALAAQVGGIGIAPGANI------GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR 365 + G +G+ P A++ L+E HG+AP ++KVNP + ILSA MML+ Sbjct: 255 EASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-PKNKVNPIATILSAAMMLK 313 Query: 366 -HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + E I ++ ++A T D +E GDA+ E + Sbjct: 314 LSLNLPEEGKAIEDAVKKVLDAGIRTGDL------GGSNSTTEVGDAVAEEV 359 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 301 bits (771), Expect = 3e-80, Method: Composition-based stats. Identities = 102/388 (26%), Positives = 155/388 (39%), Gaps = 60/388 (15%) Query: 39 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 97 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 98 AIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVIF 152 + G L P + R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 153 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 212 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 213 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTG 272 A +YA AN R VT+ K N M+ + +++ + Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEVRAQY-------------------- 214 Query: 273 KEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGD-- 330 EI V DA ++ P ++ VI NL GD ++D AA GG+G+A AN+ Sbjct: 215 PEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGAALQGGLGMAASANVHASD 274 Query: 331 --ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKT 388 ALFE HG+AP AG+D NP + +L+A ++L H+GW E I + + A++ Sbjct: 275 PARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLGWPEEERRIERWVSQALDQGM 334 Query: 389 VTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D L G + E + Sbjct: 335 CTVDV------GGTLGTRAAGAWVREQI 356 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 300 bits (769), Expect = 6e-80, Method: Composition-based stats. Identities = 100/394 (25%), Positives = 158/394 (40%), Gaps = 68/394 (17%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 + + + + GDGIG +V A + A A + + + E G + + G V Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV 57 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTP 138 ETL E + G + P G + +ALR+EL + LRPV Sbjct: 58 --SKETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALS 115 Query: 139 --SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 SP++ E D++I RE + Y G + E Sbjct: 116 GSSPLRPGVAEGVDLLIVRELTGGAYFG------------------------EKEEGEER 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + + +R+ R A E A R V V K N++ T ++ ++AR+ Sbjct: 152 ASDLSVYTRGEVERVARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDY-- 207 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALA 314 ++ ++ V+ DA ++ P +DVI NL GD +SD A Sbjct: 208 ------------------PDVALEHVLVDAAAMHLVTDPGRFDVILTENLFGDILSDEAA 249 Query: 315 AQVGGIGIAPGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTE 371 G +G+ P A++G+ +FE HG+AP AG+ NP + ILSA MM RH +G E Sbjct: 250 VLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPYAAILSAAMMFRHGLGRPE 309 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKC 405 AA+ I +G+E A+ A +T D Sbjct: 310 AAEAIERGVEAAVAAGCLTPDL------GGSSGT 337 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 300 bits (768), Expect = 7e-80, Method: Composition-based stats. Identities = 88/415 (21%), Positives = 148/415 (35%), Gaps = 73/415 (17%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I + GDGIG ++ + L V++ E+ G + + G Q G Sbjct: 1 MKRDLRFHIAVLPGDGIGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG- 57 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQG 136 E + ++ + G + P G + + LR E+DLY LRP+R Y Sbjct: 58 -TAFSDENMAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPS 116 Query: 137 TPSPV--KHPELTDMVIFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 P + K D+V+ RE +E I Y+ + + Sbjct: 117 LPRVLVDKRASQIDLVLVREQTEGILYS----------------------RCRGTIEDDR 154 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDR-----DSVTLVHKGNIMKFTEGAFKDWGYQL 248 S GT R+ A A + V V + N + + F+ ++ Sbjct: 155 VAWETMMISRNGTSRVSEFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEV 213 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A + D +++ P E+DV+ N G Sbjct: 214 AER--------------------HPSVSADYAYVDTTAMKLVKSPWEFDVLVTENAFGGI 253 Query: 309 ISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMG 368 +SD A VG +G+AP A+IG++ A+F+ HG+AP AGQ NP + ILS +ML + Sbjct: 254 LSDLAAGVVGSLGLAPSADIGEKHAVFQPAHGSAPHIAGQGLANPVAQILSVALMLDWLA 313 Query: 369 -------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ +E A+ ++ + AII + Sbjct: 314 DQHGEPRLAHGARILEHAVEKALT-------VVCPVEFGGKDGTAAITKAIIAQI 361 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 299 bits (766), Expect = 1e-79, Method: Composition-based stats. Identities = 101/400 (25%), Positives = 170/400 (42%), Gaps = 62/400 (15%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++ ++V++AA ++ + + G S Q +G + Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKR---FQLDLEIGHDIAGHASLQRHG--ATVTPA 56 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ ++ + GP+ T G + + R+ELDLY +RP R + G V Sbjct: 57 LLEKVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV-- 114 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 ++ + REN+E YA E G ++ I ++ + Sbjct: 115 -GEFNLAVVRENTEGFYADRN----------------IESGSSEMLITPDTVISLRRITR 157 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 +R+ R+A + A R V++VHK N++K +G F D Q+ARE Sbjct: 158 LCCERIARSAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVAREF----------- 205 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 ++ + D I DA + ++ P +DVI N+ GD +SD A G +G+ Sbjct: 206 ---------PQVRVDDFIVDAMMAHVVRAPQRFDVIVTTNMFGDILSDLTAELSGSLGLG 256 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE-------AADLI 376 N G + A+ +A HG+AP AG++ NP S+ILSA +L G + AA I Sbjct: 257 GSLNAGKDHAMGQAVHGSAPDIAGRNIANPYSLILSAGQLLGWHGQRKNLPAFALAARAI 316 Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A+ A+ T D L +E G + + + Sbjct: 317 DETATAALQAREGTRD------AGGELGTAEAGQSFVRRL 350 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 102/393 (25%), Positives = 158/393 (40%), Gaps = 64/393 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +V LKV+ A + G Q G+ LP Sbjct: 2 RLAVIPGDGIGPEVVAEGLKVLRAVAP-------DVESTPYDLGASRWQRTGE--LLPDT 52 Query: 88 TLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD +R + + G + P G R L + LR ELD ++ LRP R + G SP+ P Sbjct: 53 VLDELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAP 112 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 DM+ RE +E Y G GV + P + + Sbjct: 113 GAIDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAF 153 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G +R+VR A E A+A R +TL+HK N++ + +++ E Sbjct: 154 GVERVVRYAFERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEF------------ 201 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 E+ + DA + P +DVI NL GD ++D AA GGIG+A Sbjct: 202 --------PEVTVAYQHVDAASMFFVTDPGRFDVIVTDNLFGDIVTDLAAAVTGGIGLAA 253 Query: 325 GANI---GDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 N+ G ++FE HG+AP AG+ +P + +LS ++L H+G + A + + Sbjct: 254 SGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSVGLLLDHLGRADQARKVNAAVA 313 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +D D ++ + GD + Sbjct: 314 ---------FDLS-TRDPEAQVRTEDVGDRLAA 336 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 110/396 (27%), Positives = 168/396 (42%), Gaps = 65/396 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 ++ I IEGDGIG +V PA + V+ A E S+ E G+ + G Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE------VGFSFTEKQAGDDTRDQTG- 53 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 140 LP T + + + G + + LR+ + ++ +RP R Y G + Sbjct: 54 -AALPETTYEAAADADATLFGAAG----ETAADVILPLREAVGSFVNIRPARAYPGVDAL 108 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 TD+V REN+E +Y+G E R E + Sbjct: 109 ---QPETDLVFLRENTEGVYSGHE-----------------------DRLSEDLSTLTRV 142 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + +++L A Y D VHK N+M+ T+G F+D ++A Sbjct: 143 ITTSASEQLAEYACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVAA---------- 192 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ +V+ DAF ++ L P ++DV+ C NL GD +SD A VGG+ Sbjct: 193 -----------SNDVATNEVLMDAFATRVCLNPTQFDVVVCPNLAGDVLSDLAAGLVGGL 241 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 G+ P ANIG ALFE HGTAP AG NP + ILSA M+L ++G T+AA + + Sbjct: 242 GLLPSANIGQTNALFEPVHGTAPDIAGDGIANPSASILSAGMLLEYLGETDAATNVQMAV 301 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 E +N+ T D +A+IE + Sbjct: 302 ESVLNSGPRTPDL------GGNASTEAVVNAVIEQL 331 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 296 bits (759), Expect = 7e-79, Method: Composition-based stats. Identities = 89/411 (21%), Positives = 149/411 (36%), Gaps = 71/411 (17%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + G S + L Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAG-KFNLQNHLLGGASIDKHNDP--LT 59 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG-----IRSLNVALRQELDLYICLRPVR-----YYQ 135 E L+ + + G + P G + LR+EL Y LRP Sbjct: 60 DEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVD 119 Query: 136 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 +P + TD ++ RE + IY G + D + Sbjct: 120 SSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSG----------------------YA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 +P S R+ R A A+ N V + K N++ T ++ + +EF Sbjct: 158 CDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ ++ + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 + G IG+ P A++G ++E HG+AP +G+ VNP ILS MMLR+ Sbjct: 258 SVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRY 317 Query: 367 -MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + AD + ++ AI+ T T D S+ G+A++ + Sbjct: 318 SLNLPKEADAVEAAVKAAIDNGTKTKDL------GGNATTSDMGNAVVAEL 362 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 88/418 (21%), Positives = 149/418 (35%), Gaps = 69/418 (16%) Query: 24 PENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 I + GDGIG +V +V++ + E K+ + G S +G+ Sbjct: 3 KRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDF--GGCSIDKHGEP-- 58 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQGTP 138 L A TL+ + + G + P G +ALR+ L LY +RP + + Sbjct: 59 LTAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSL 118 Query: 139 ---SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 193 SP+K D+++ RE Y G + R E Sbjct: 119 LAYSPLKPSVARGVDIIVIRELIGGAYFGERKELG-------------------ARAQED 159 Query: 194 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 160 AAWDTMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL-ASSRLWRKVATETIQNEF 218 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDA 312 ++ + + D+ I+ P + + VI NL GD +SD Sbjct: 219 -------------------PQLKLDHHLVDSASMLIVANPKKLNGVILTENLFGDILSDE 259 Query: 313 LAAQVGGIGIAPGANIGDEC-------------ALFEATHGTAPKYAGQDKVNPGSIILS 359 + G +G+ P A++ ++E HG+AP AGQ NP ILS Sbjct: 260 SSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIANPIGTILS 319 Query: 360 AEMMLRHMG-WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A M+ W A I +EGA + R D K + G ++E + Sbjct: 320 AAMLCGTRSVWRSPAKAIEAAVEGARRQGDR-REGLRTADLGGSSKTKDIGHKVVEIL 376 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 119/420 (28%), Positives = 190/420 (45%), Gaps = 70/420 (16%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 V+ AQG + + II GDGIG +T ++++ ++ K+ + Sbjct: 26 VMKAQGDFLNY-----QALDKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQG-KVEF 79 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQE 121 I G + + +PAE L ++E V +KGP TTP + S NVA+R+E Sbjct: 80 KVID-GLTIERRAAEHAAIPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKE 138 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDL+ +RPVR + + D +REN+E YA Sbjct: 139 LDLFANVRPVRIPE---------QGIDWTFYRENTEGAYA-------------------- 169 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +G K I E G+ + G++R++RAA EYA AN + VT V K NI+K T+G F Sbjct: 170 -VGSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDGKF 228 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQIL--LRPAEYDVI 299 D ++A++ K+I D D +++ R ++ V+ Sbjct: 229 LDIFREIAKDY--------------------KDITADDWYIDIMTAKLIDEKRRKDFQVM 268 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD I+D A GG+G A ANIG ++FEA HG+AP+ + + +P S+ Sbjct: 269 VLPNLYGDIITDEAAEFQGGVGTAGSANIGKRYSMFEAIHGSAPRMVQEGRDQYADPCSV 328 Query: 357 ILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I + M+L H+G+ + AD + + ++ TVT + +EF D I+E + Sbjct: 329 IRAGAMLLAHIGYGKEADKLYQALDIC----TVTEKKLVITGRNTGATGAEFADYIMETI 384 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 291 bits (744), Expect = 4e-77, Method: Composition-based stats. Identities = 108/396 (27%), Positives = 154/396 (38%), Gaps = 64/396 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +V L V+DA + + G+ L Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGS 72 Query: 88 TLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 LD IR A+ G + P G +R + LR ELDLY+ RP R + SP++ P Sbjct: 73 DLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDP 132 Query: 145 --ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 D VI REN+E +Y+GI G + PE + + + Sbjct: 133 ARRAIDCVIVRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLST 173 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 G R++ A A R SV LV K N ++ ++ + Sbjct: 174 RHGVSRVLEFAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVAR----------- 218 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 I + D ++ P +DVI N GD +SD AA GG+G+ Sbjct: 219 ---------HPHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDILSDLTAALAGGLGV 269 Query: 323 APGANIGD--ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 A AN+ ALFE HG+AP AG NP ILS ++ H+G E AD + + + Sbjct: 270 AASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAEHLGRNEEADAVRRAV 329 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ A VT D L E G A++ + Sbjct: 330 AAAVAAGRVTPDL------GGPLGTKEVGAAVLAEL 359 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 100/457 (21%), Positives = 167/457 (36%), Gaps = 96/457 (21%) Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64 + +Q K L + + GDGIGV++ + ++ A +S Sbjct: 16 IQAASQPSKAFFSQSALQREAIKKVTLLPGDGIGVEICSCVCELFHYANIPIQWDTYLVS 75 Query: 65 WMEIYTGEKS-----------------------------TQVYGQDVWLPA----ETLDL 91 G S + P + Sbjct: 76 GSFFGVGSDSSLNPTRNLIEEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQS 135 Query: 92 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMV 150 I +V +KGP T +S++ L + LY + PV+ Q P V P DMV Sbjct: 136 ILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMV 193 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 210 + REN+E Y+G+E + E +K + +G+ R+ Sbjct: 194 VVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRDGSMRIA 230 Query: 211 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPN 270 + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 231 KWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEY------------------ 272 Query: 271 TGKEIVIKDVIADAFLQQILLRPAEYD--VIACMNLNGDYISDALAAQVGGIGIAPGANI 328 +I ++I D + Q++ P +D V+ NL G +S+ ++ VGG+G+ G N Sbjct: 273 --PDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNA 330 Query: 329 G-----DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEG 382 D +FE A +G+ NP +I S+ ML HMG A+ I ++ Sbjct: 331 TDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMGMNTHANRIKFALKE 390 Query: 383 AI---NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + N K +T D F +A++ ++ Sbjct: 391 TLLNANPKILTPDI------GGTGSSVSFIEAMMRHI 421 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 286 bits (733), Expect = 8e-76, Method: Composition-based stats. Identities = 86/406 (21%), Positives = 163/406 (40%), Gaps = 61/406 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG +V +KV+ ++ + ++ G + G P Sbjct: 3 TYNIALLAGDGIGPEVMKEAVKVLKLIEQR--NEDVNFELNDVLFGAAAYFAMGH--AFP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGG---------IRSLNVALRQELDLYICLRPVRYYQG 136 ET + +KG + R + LR+ + + RPV +G Sbjct: 59 DETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKG 118 Query: 137 TP--SPVKHP---ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191 SP+K E D++I RE +Y G + +AD ++ ++ + E Sbjct: 119 LAHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLE---------- 168 Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E+ +++V+ E ++ + + +HK N++K + + + + ++ Sbjct: 169 ---------YDEDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKN 217 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 E+ +K+++ DA + L P +DV+ N+ GD +SD Sbjct: 218 Y--------------------PEVEVKNILVDAAATYLCLNPGMFDVMVMENMFGDILSD 257 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGWT 370 +G +G+ P A G + + +E +HG+AP AG+ NP S+I S +ML G Sbjct: 258 QGGGILGSLGLMPSACKGPDKSYYEPSHGSAPDIAGKGIANPYSMIGSVALMLEMSFGLE 317 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + A + M+ T D + + A L+ +EFGD + + Sbjct: 318 KEAKNLWAAMQAVFENGYSTSDLSKEGE-ANLVSTAEFGDLVCAEL 362 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 284 bits (726), Expect = 5e-75, Method: Composition-based stats. Identities = 84/415 (20%), Positives = 146/415 (35%), Gaps = 84/415 (20%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GD IG ++ LK++ E+ + +IS+ G S G + E Sbjct: 6 KLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISY--GLIGGASLDKTG--SAITDE 61 Query: 88 TLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGT---P 138 L+ + G + P + LRQ LD + +RP R+Y + Sbjct: 62 VLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQ 121 Query: 139 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 SP+K D V+ REN Y G + + + Sbjct: 122 SPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDE-------------------------- 155 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDS---------VTLVHKGNIMKFTEGAFKDWGYQ 247 + +R R + A R V K N++ + ++ + Sbjct: 156 -----ARTEVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL-ASGRFWRTVTHD 209 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNG 306 + EF +I + D +AD+ ++ P +++ VI N G Sbjct: 210 IFEREF-------------------PDIELHDQLADSMAMVMVKAPTKFNGVIHTDNTFG 250 Query: 307 DYISDALAAQVGGIGIAPGANIG-------DECALFEATHGTAPKYAGQDKVNPGSIILS 359 D +SD VG +G+ P A++ ++EA HG+AP +G + NP + ILS Sbjct: 251 DILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSAPDISGTGQANPIAQILS 310 Query: 360 AEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 M+LR+ ADL+ + + + R D + GDA+ Sbjct: 311 LAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 283 bits (724), Expect = 7e-75, Method: Composition-based stats. Identities = 89/415 (21%), Positives = 153/415 (36%), Gaps = 68/415 (16%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + K K + + + I G+G+G ++ A+ +V+ A Sbjct: 62 QDKQKSKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKA------- 114 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W + E L +R +V IKGP+ + R +R++ Sbjct: 115 PIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQ 163 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 + + + +G SP D+VI R+ E Y+GIE + Sbjct: 164 FAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVVPGVMQT------- 213 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 IK + G R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 214 ----------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 257 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 + A + +++ ++ D + +ILL+P + DV+ Sbjct: 258 LEAMRAEADKHVD-------------------DVLFEERYLDTCILKILLKPHKCDVMVS 298 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 361 ++ GD + +G GI PG ++ +F+ AG+D NP +LSA Sbjct: 299 SSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAA 358 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MLRH+ + AD + + D R D KCSEF A+ + + Sbjct: 359 LMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 85/346 (24%), Positives = 145/346 (41%), Gaps = 55/346 (15%) Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG--GGIRSLNVALRQE 121 + E++ + + + IR RVA+KG + T +S N LR Sbjct: 1 DFEEVHVSSNADEE------DIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTS 54 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 LDLY + + G V + D++I REN+E Y+ +E ++ + E Sbjct: 55 LDLYANVIHWKSLPGV---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-------- 103 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 +K ++ + R+ A + A + R VT VHK NIMK +G F Sbjct: 104 ---------------SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLF 148 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 ++A +I +++I D Q++ RP ++DV+ Sbjct: 149 LQCCREVAARY--------------------PQITFENMIVDNTTMQLVSRPQQFDVMVM 188 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQDKVNPGSIILSA 360 NL G+ +++ A VGG G+ GAN G A+FE AT T A ++ NP + +L++ Sbjct: 189 PNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLAS 248 Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCS 406 MML H+ A I K + +++ + V + + + CS Sbjct: 249 CMMLDHLKLHSYATSIRKAVLASMDNENVRFPSHPTLLPRPVSPCS 294 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 280 bits (716), Expect = 7e-74, Method: Composition-based stats. Identities = 91/387 (23%), Positives = 152/387 (39%), Gaps = 48/387 (12%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I I GDGIG ++ P + +V + +++ + G + + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDP-------SVNFTFYNISSERYINKG--ITIKDSE 54 Query: 89 LDLIREYRVAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 +D ++ Y G + G + + + LR+ELDLY+ +RP + Sbjct: 55 IDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----N 109 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 M I REN ED Y+ I + + + + S + Sbjct: 110 NIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKN 169 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 KR A + A D ++VT+ K N + +++ + Sbjct: 170 LKRFFNMAYKIA---DTETVTITDKANAVDMYS-LWREIAIE------------------ 207 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 + I AD+ ++ P +Y I NL GD +SD +A VGG+G AP Sbjct: 208 ---ESEPAGKKINFEYADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPS 264 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 NIGD ++FE HG+AP AG++ NP + ILS MML+H+ TE A ++ K +E I Sbjct: 265 GNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVENVIR 324 Query: 386 AKTVTYDFERLMDGAKLLKCSEFGDAI 412 T+ ++ EF + + Sbjct: 325 NGTI------PIESGGNAGTHEFINKV 345 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 280 bits (715), Expect = 9e-74, Method: Composition-based stats. Identities = 102/422 (24%), Positives = 165/422 (39%), Gaps = 78/422 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I + GDGIG ++T A ++ E +I W + + +G V P E Sbjct: 16 RITLLPGDGIGPEITDACRGLIADVFPHWELTETQIGWSQ-------WRAHGNPV--PQE 66 Query: 88 TLDLIREYRVAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVR 132 T + + A+ +T+ G RS + LRQ LDL+ +RPV Sbjct: 67 TWETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV- 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAG------IEWKADSADAEKVIKFLREEMGVK 186 G + D I REN+E +Y+ + ADS + + + + Sbjct: 126 TLPGAAA--------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVAR 177 Query: 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND--------RDSVTLVHKGNIMKFTE 238 + + ++ + RL R A + A+A +VT+ K NI++ + Sbjct: 178 AVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSA 237 Query: 239 GAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDV 298 + ++A E ++ ADA Q++ PA +DV Sbjct: 238 RVIRGAVEEVAEEY--------------------PQVAFDFANADAVAMQLVTDPARFDV 277 Query: 299 IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIIL 358 I NL GD +SD A +GG+G+A AN+GD A+FE HG+AP AG+ NP + +L Sbjct: 278 IIAENLIGDILSDIGAGLIGGLGLAASANVGDNFAVFEPVHGSAPDIAGRGIANPAAFLL 337 Query: 359 SAEMMLRHMGWT----EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 SA M H+G A + + + A +D SEF A+ Sbjct: 338 SAAMCAEHLGAPVSELAPAAKLREAVYAATRT-------APTLDLGGTATTSEFVAAVRA 390 Query: 415 NM 416 + Sbjct: 391 EL 392 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 75/388 (19%), Positives = 150/388 (38%), Gaps = 58/388 (14%) Query: 31 YIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD 90 + GDGIG ++ ++K+V + + KI+ + Y G S + + + Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCI----YTGYKINIIYNYIGGISIDKFNTP--ITNNLIS 59 Query: 91 LIREYRVAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 +I+ G + + LR++ + + +RP++ P K Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---N 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D++I RE + IY G + P K +E+ Sbjct: 111 IDIIIVRELNGGIYYGKPKGFSKQII---------------NQIPTWYAYNTKIYNEQEI 155 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 RL R + A+ N + + + K N+++ T +K + + Sbjct: 156 IRLARISFNLAL-NRKKKLCSIDKSNVLE-TFKLWKKTINYVHKFY-------------- 199 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ + + D ++ ++DVI NL GD ISD + G +G+ P Sbjct: 200 ------NKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGMLPSI 253 Query: 327 NIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAI 384 +I ++ +LFE HG+AP A ++ NP +LS MM + + + ++ + + + Sbjct: 254 SINNKSLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYVLNDFKLSNNLYYSIYKVL 313 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAI 412 + T D ++ + K++ EFGD + Sbjct: 314 SYGFCTIDMKKYIRNFKIVSTEEFGDLV 341 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 276 bits (706), Expect = 1e-72, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 143/278 (51%), Gaps = 34/278 (12%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + I GDG G ++ A +V++A W G + G LP Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPD 53 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E Sbjct: 54 SVLESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF---EN 110 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D+V+ REN+ED+YAGIE++ + + ++ +L ++ E GI IKP S G+ Sbjct: 111 IDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRP--NALIKEPGGISIKPMSVPGS 168 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEY-------------- 214 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304 +I D I D Q++ +P YDV+ NL Sbjct: 215 ------PDIEFDDRIVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 93/399 (23%), Positives = 156/399 (39%), Gaps = 65/399 (16%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + + G GIG ++ L+V+ AA +S+ K Sbjct: 32 SKYGGKTNVTILTGSGIGPEIMDHTLRVLKAA-------GAPLSYEIFALSSKDGSKNND 84 Query: 81 DVWLPAETLDLIREYRVAIKGPLT-TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 E L IR RVA+KG + I+S N+ R+ LDL++ + + + G Sbjct: 85 F----DEALTSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLS- 139 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 D+ + R+N+E Y +E + + E +K Sbjct: 140 --NKFGEIDITVIRQNTEGEYLMLEHEPRTGSVE-----------------------SLK 174 Query: 200 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELID 259 + +RL+ A +YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 175 VLTRFNLERLIEFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSY------- 227 Query: 260 GGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG 319 I + + + + +I P +DVI NLNG IS+ L +GG Sbjct: 228 -------------PMIKMNVLDVNVAIFKIASNPRIFDVILATNLNGSMISNYLNGMLGG 274 Query: 320 IGIAPGANIG-DECALFEA-THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 G+ G N D A+FE G ++ NP ++I+S +L H+G+ + A++I Sbjct: 275 PGLTSGINFSADGIAVFEPGARNKGSSIVGLNRANPIAMIMSGINLLHHLGYNKTAEMIH 334 Query: 378 KGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + YD R D E D II ++ Sbjct: 335 NSVYATL-----VYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 268 bits (685), Expect = 3e-70, Method: Composition-based stats. Identities = 85/396 (21%), Positives = 150/396 (37%), Gaps = 61/396 (15%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I G+GIG +V A LK++ + + + G + + G + P Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAK---IQGFTLQVDYGWLGATAFEQLG--SYFP 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGT----PSPV 141 T +L + G ++ + + LR+ D + LRP+R Sbjct: 63 QATTELCDGADGIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRP 115 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + + D++I RE IY G ++ + G Sbjct: 116 EKIQGLDILIVRELVSGIYFGPSGRSSDE--------------------RGNYGYHTMRY 155 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 +E +R+ R A+E A R +T+ HK N + + + A + Sbjct: 156 YDEEIRRIARKALEQAQYR-RGLLTVAHKENALPHLH--WTRLVQEEATKF--------- 203 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 ++++ ++ D Q++L P +DVI NL GD +SD A VG IG Sbjct: 204 -----------PNVIVEPMLVDNLAMQMVLNPQRFDVILASNLFGDILSDIGGALVGSIG 252 Query: 322 IAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM 380 + A++ L+EA HGTAP AG NP + + +ML+ G +AA I+ Sbjct: 253 LLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLGACVLMLQQWGEVQAAQQIIAAQ 312 Query: 381 EGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D + L+ + D ++E + Sbjct: 313 DRILAKGYRTADLFTQGEEI-LVNTATLVDLLLEEL 347 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 268 bits (684), Expect = 4e-70, Method: Composition-based stats. Identities = 95/407 (23%), Positives = 157/407 (38%), Gaps = 67/407 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I+GDGIGVDV A + V++ A++ + GE + EI G + G D + Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLD--IEDG 57 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 + G + P G S ++ LR LY +RPV+ Y P + Sbjct: 58 GEERAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLAD 117 Query: 144 PE--LTDMVIFRENSED-IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 P D+VI RE++E Y+ K + + + Sbjct: 118 PRAAGIDLVILRESTEGLFYSAAAHKRS-------------------LVVNDDEVQDVLR 158 Query: 201 CSEEGTKRLVRAAIEYAIAND----RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 + + T +L R A A +T V K N+ + F+ ++ E Sbjct: 159 ITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSEFA--- 214 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + DA ++ +P E+DV+ N+ GD +SD Sbjct: 215 -----------------DVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGDILSDLAGGL 257 Query: 317 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT------ 370 VGG+G+A IGD LF+ HG+AP G+DK NP + ILSA +ML ++ Sbjct: 258 VGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYLAEKLDKPSL 317 Query: 371 -EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +AA+LI +E + R ++ + ++ + Sbjct: 318 ADAAELIDSAVETGFWHNAL-----RPIEFGGDMGTRAVTKELLGRV 359 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 103/423 (24%), Positives = 169/423 (39%), Gaps = 79/423 (18%) Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65 P + L ++ + + GDGIG + L+V ++ K+ + Sbjct: 34 QAPGRKDFKKL--------DHITVGILPGDGIGPCIMEQALRVAKYLLKDEMASG-KVEF 84 Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP----VGGGIRSLNVALRQE 121 I G + ++ LPAE L+ + V +KGP TP + S N LR+ Sbjct: 85 RTIP-GMTIEERVQKNESLPAEVLEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRA 143 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RPVR + + D FREN E Y Sbjct: 144 LQLYAAVRPVRIPE---------KGIDWTFFRENIEGEYI-------------------- 174 Query: 182 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 G K I+ + + K + G +R+ RAA E+A N + +VT+V K NI+K +G F Sbjct: 175 -WGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNF 233 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR--PAEYDVI 299 + L +E I +++ + D+ +I + V Sbjct: 234 LKTAHALEKEY--------------------PGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 300 ACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSI 356 NL GD ++D A GG+G A +NIGD+ ALFEA HG ++ +P S+ Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQYALFEAIHGVGNFLVQHNRAQYADPCSL 333 Query: 357 ILSAEMMLRHMGWTEAADLIVKGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 I + M+ H+G+ E + +VK ++ +T D + EF D ++ Sbjct: 334 IRAMGEMISHIGYPEKKEQLVKALDICTRTERKVVITTDKD-------GATAEEFTDYLL 386 Query: 414 ENM 416 + + Sbjct: 387 DTL 389 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 266 bits (680), Expect = 1e-69, Method: Composition-based stats. Identities = 100/411 (24%), Positives = 156/411 (37%), Gaps = 86/411 (20%) Query: 42 TPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAI 99 LKV+ A E I W ++ G + G W P++ + + Sbjct: 1 MREGLKVLHAVSEP-----LGIEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLIL 54 Query: 100 KGPLTTPVGGGIR-------------SLNVALRQELDLYICLRPVRYYQGTPSPVK---- 142 G + P G S + R L+LY +RP++ Y G + Sbjct: 55 LGAVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHK 114 Query: 143 ---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 199 DMVI REN+E +YA K I + Sbjct: 115 QIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKA-------------------DVAIDTR 155 Query: 200 PCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 156 VITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEY 214 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 EI I DAF Q ++ +P YDV N+ GD ++D Sbjct: 215 --------------------PEIEKDTAIVDAFTQWLVGQPEYYDVCVTSNMFGDIVTDL 254 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + GG+G+A G NIG A+FE HG+APK+AG+DKVNP ++ILS + L + + Sbjct: 255 ASTLQGGMGMAVGGNIGKHNAMFEPIHGSAPKHAGKDKVNPIAMILSVKEGLEWLAARKD 314 Query: 373 ADLIVK-------GMEGAINAK-TVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + K + + T+TYD + + KCSE G AI E Sbjct: 315 DATLTKAAEAIEAAVVEVLEKGETLTYDL---VGNDRASKCSEVGSAIAEA 362 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 263 bits (672), Expect = 9e-69, Method: Composition-based stats. Identities = 75/423 (17%), Positives = 145/423 (34%), Gaps = 90/423 (21%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 ++ + P+ + ++GD IG +V +L + D K+ E G Sbjct: 3 RSSGKDAPKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSH---FGIKVETFERLIGGSCLD 59 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRP 130 + + TL E + G + P + + +R+ L+LY +RP Sbjct: 60 QHDCP--IQESTLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRP 117 Query: 131 VRYYQGTP---SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185 + S +K +++ REN+ IY G + + D Sbjct: 118 AKIISERQLELSSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH------------- 164 Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245 +AA+ A ++ + V K N+M T ++ Sbjct: 165 -------------------------KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVV 198 Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNL 304 + R+EF + + + D+ + P + + V+ NL Sbjct: 199 TETIRDEFPQLMD-----------------KLSHQLVDSAAMLLAKDPRKLNGVVLTENL 241 Query: 305 NGDYISDALAAQVGGIGIAPGANIGDEC----------ALFEATHGTAPKYAGQDKVNPG 354 GD +SD + G +G+ A I +++ G+AP AG+ NP Sbjct: 242 FGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIANPI 301 Query: 355 SIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413 + +S +M R +G +AAD I ++ + + T D L + G A+ Sbjct: 302 GMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV------GGTLSTQQAGSALR 355 Query: 414 ENM 416 +++ Sbjct: 356 QSI 358 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 93/363 (25%), Positives = 153/363 (42%), Gaps = 52/363 (14%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + I GDGIG ++ P + + + I+++ + G + + + Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS--------DINFVTFDISSERYIKTG--IIIKDDE 53 Query: 89 LDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 L+ ++ YR + G + P G + + + LR+EL+LY+ +RPVR + + Sbjct: 54 LEELKNYRAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------D 104 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 + I REN++D Y I + V E G G+ Sbjct: 105 KIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGML-------- 156 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + R ++ A + +VT+ K N +K ++ + A E Sbjct: 157 SYRYLKKFFNKAFSICDSTVTVTDKANAVKMYN-LWRSTAMEAAIE-------------- 201 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 K I I ADA ++L P +Y I NL GD ISD AA VGG+G AP Sbjct: 202 -------KNINISFEYADALAYNMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPS 254 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 ANIGD+ ALFE HG+AP AG+D NP + I++ M+L ++G+ + + +I + Sbjct: 255 ANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYLGYRDESRIINDMVRNLYI 314 Query: 386 AKT 388 Sbjct: 315 NGV 317 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 100/377 (26%), Positives = 161/377 (42%), Gaps = 66/377 (17%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +++G G+G D ++ ++ AA + + + G + + +G+D LP Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAA-------KVPVEFEVHLAGRMALE-HGKD-ALPKA 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGG----------IRSLNVALRQELDLYICLRPVRYYQGT 137 T D IRE +A+K L P G G + NVA R++L L+ +RPV G Sbjct: 54 TFDAIRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGI 113 Query: 138 PSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 197 PS D ++FRE +ED+Y E + + Sbjct: 114 PSRFT---GVDFLLFREITEDLYTASEHEIVPGVVQ-----------------------S 147 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 K +E R + A + A R +V +HK NI+K +G F + Y++A+E Sbjct: 148 FKIVTEAACLRFFKLAFDTARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEY----- 202 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 EI KD+I D Q++ RP +++V+A NL GD +SD A V Sbjct: 203 ---------------PEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGAGLV 247 Query: 318 GGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIV 377 GG+ N G+ ++EA +G + + D NP +IL A +L+ +G T A I Sbjct: 248 GGVSTTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETGTAGRIQ 307 Query: 378 KGMEGAINAK-TVTYDF 393 K +E + T D Sbjct: 308 KAVETVLLEGRIRTRDI 324 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 100/407 (24%), Positives = 162/407 (39%), Gaps = 109/407 (26%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I I GDGIG +V PA ++++A K + +++ G ++ + G L Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEAL---PSYLGLKFEFTDLHAGFETFERTG--AAL 58 Query: 85 PAETLDLIR-EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 P +T++++R E A+ G +++P G S VALR++LDLY +RPV+ + Sbjct: 59 PDKTVEILRNECDGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTV------L 112 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + DMVI REN+ED+Y E D+ D + IK Sbjct: 113 SAAKPIDMVIVRENTEDLYVKEETTRDTPDGK--------------------VAEAIKRI 152 Query: 202 SEEGTKRLVRAAIEYAIANDR------------DSVTLVHKGNIMKFTEGAFKDWGYQLA 249 SE + R+ A + A+ + VT+ HK N++ Sbjct: 153 SERASHRIATMAGDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL--------------- 197 Query: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 + +K+VI D NL GD + Sbjct: 198 -------------------------LRLKNVIVD------------------PNLYGDIL 214 Query: 310 SDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 SD AA VG +G+ P AN+G+ A+ E HG+AP GQ+ NP + + SA +ML + Sbjct: 215 SDDAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIMGQNIANPIATLRSAALMLEFLDE 274 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AA I ++ + + D K +E + I+ + Sbjct: 275 EAAAAKIYAAVDANLTEGKL-----LSPDLGGTAKTTEVIEDILRRL 316 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 257 bits (656), Expect = 6e-67, Method: Composition-based stats. Identities = 113/404 (27%), Positives = 198/404 (49%), Gaps = 39/404 (9%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + + VP+ I YI+GDGIG ++T AM+ VV++A+E AY+G R I W +I G Sbjct: 10 YIEFTDSGMVVPDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGT 69 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + +G ++P +++ I++ +A+K L R LN LR+ L LY +R ++ Sbjct: 70 EAYEKFG--TYVPEDSIKEIQKMYIAMKSTL--NFMPDKRDLNTILRKRLGLYSNIRILK 125 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 Y +G PV ++ I R+++ + + + S + +I+F+ + G + Sbjct: 126 YIEGMDIPVNTFNRLNLTIIRDSTPNSHI---FYHSSESTDDLIRFISDNYG---LNITP 179 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 GI + P S+ T+++ + A+ Y+ N + +T++ F +W + A Sbjct: 180 DSGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEA--- 231 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + +++ + + F+++++ P +++VI N+ + D Sbjct: 232 -----------------SAQEDVGYEVLKTREFMKRLISSPEDFEVILVDNVLSQTLVDY 274 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 LA G I I G++IGDECA+FEA + P AG D +P S ILS ML H+GW EA Sbjct: 275 LA---GTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEA 331 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A +I + A + D D +KCSEF II+ M Sbjct: 332 AQIIENAISAAFRDNKIPKDINTRPDI-SPIKCSEFSSEIIKRM 374 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 256 bits (654), Expect = 1e-66, Method: Composition-based stats. Identities = 97/402 (24%), Positives = 164/402 (40%), Gaps = 73/402 (18%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GDGIG + A L V ++K +R + ++ I G + Q+ LP Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQR-VEFVPIK-GMTIEERARQNKSLPPA 96 Query: 88 TLDLIREYRVAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 L+ + + +KGP TP + S N LR++L LY +RP+R + Sbjct: 97 VLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE-------- 148 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 + D FREN E Y G K I + I K S+ Sbjct: 149 -KGIDWTFFRENIEGEYI---------------------WGNKGICVGDDLAIDFKILSK 186 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 G +RL R A EYA ++ + ++T+ K NI+K +G F + + +E Sbjct: 187 PGAERLFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEY----------- 235 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPA---EYDVIACMNLNGDYISDALAAQVGGI 320 I +++ + D+ +++ P V NL GD ++D A GG+ Sbjct: 236 ---------PGIHVREELIDSLSAKLM-DPEFNAGMQVFVLPNLYGDILTDIAAEYQGGL 285 Query: 321 GIAPGANIGDECALFEATHGTAPKYAGQDK---VNPGSIILSAEMMLRHMGWTEAADLIV 377 G A +NIGD+ A+FEA HG ++ +P S+I + M+ +G+ E D + Sbjct: 286 GTASSSNIGDQYAMFEAIHGVGVYLVEHNRAQYADPSSLIRAMGEMMAFIGYPEKRDRLF 345 Query: 378 KGME---GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 K ++ +T D + EF + ++E + Sbjct: 346 KALDFCTKVERKAVITTDKD-------GATAEEFAEYVVETL 380 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 102/355 (28%), Positives = 160/355 (45%), Gaps = 38/355 (10%) Query: 47 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 106 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGE-----DQQGLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 107 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 167 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 226 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSGK---RIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 VH+ + M T+G F + +A+E +I D + Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQEF--------------------PDIAFADRSIEVIC 222 Query: 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA 346 Q+++ +P +DV+ NL GD ++ A VGG+ + P A++GD+ A+F T Sbjct: 223 QELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVF-GAQSTGTDDV 280 Query: 347 GQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 G D P S+IL+ +MLRH+G EAA + +E + + T + Sbjct: 281 GHD---PTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVDTTADLNPVGFEG 332 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 96/429 (22%), Positives = 163/429 (37%), Gaps = 98/429 (22%) Query: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + + GDGIG +V A ++A + E+ + +PA+ Sbjct: 10 VAVMPGDGIGPEVMAATRHALEAL------PGPALVLTELGWPAHAWHR-DHGEMMPADW 62 Query: 89 LDLIREYRVAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRYYQGT 137 + Y + G L P G + + LR+ LDL+ C RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 138 PSPVKHPEL--TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 P P+ P TD+++ RENSE Y ++ G P Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTPRETA 163 Query: 196 IGIKPCSEEGTKRLVRAAIEYA----------IANDR---------DSVTLVHKGNIMKF 236 ++ + GT+R++R A E A + R +V +V K N +++ Sbjct: 164 TQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQY 223 Query: 237 TEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEY 296 + + ++A E I + DA + + +P ++ Sbjct: 224 AGELWSEVFAEVAAEY--------------------PGIATHHELIDACCMKFVSQPWQF 263 Query: 297 DVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE----CALFEATHGTAPKYAGQDKVN 352 DV+ NL+GD ++D A GG+G+AP AN+ LFE THG+AP AG D+ + Sbjct: 264 DVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGADRAH 323 Query: 353 PGSIILSAEMMLRHMGWTE-----AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 P +++L+A ML MG + +A + + + I G C+E Sbjct: 324 PAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE-----------HGMGGRGCAE 372 Query: 408 FGDAIIENM 416 G A+ + + Sbjct: 373 VGRAVAQRI 381 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 248 bits (634), Expect = 3e-64, Method: Composition-based stats. Identities = 83/368 (22%), Positives = 138/368 (37%), Gaps = 61/368 (16%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +DA E + I W + E L +R +V IKGP+ + Sbjct: 1 MDAVQEVICAVKAPIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS--- 52 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 53 ---RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVV 106 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + G R+ YA+ N R +T+ Sbjct: 107 PGVMQT-----------------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVA 143 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +++ ++ D + + Sbjct: 144 HKANIMRMTDGNFLEAMRAEADKHVD-------------------DVLFEERYLDTCILK 184 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 ILL+P + DV+ ++ GD + +G GI PG ++ +F+ AG+ Sbjct: 185 ILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGK 244 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408 D NP +LSA +MLRH+ + AD + + D R D KCSEF Sbjct: 245 DLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKD----TDI-RTPDVGGKAKCSEF 299 Query: 409 GDAIIENM 416 A+ + + Sbjct: 300 VKAVCDCL 307 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 245 bits (625), Expect = 3e-63, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 145/420 (34%), Gaps = 68/420 (16%) Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71 ++L+NG I I GDG+G ++T + + A E R + E G Sbjct: 3 DIVSLRNGS----RIYTIALIPGDGVGPEITREAVLTLKRAGE---VYGRSFQFTEAIAG 55 Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR------SLNVALRQELDLY 125 + LP E+L E + G L G++ S+ LR L L Sbjct: 56 TAALDR--GQCPLPRESLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLR 113 Query: 126 ICLRPVRYYQGTP--SPVK---HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +RP + + P+K + D++I R+ + ++ Sbjct: 114 SDIRPCFFAEALRELCPLKEEIRKKGMDILIIRDIAGGMFT------------------- 154 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240 G + E + R A + A + R VT + K I+ + Sbjct: 155 -TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQLAASRKRK-VTSLDKA-ILLSSSVL 211 Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300 ++ + R+ EI ++ ++ D +++ P +DVI Sbjct: 212 WRQILEETHRDY--------------------PEIELEHMLVDHGAFKLVSSPDAFDVIV 251 Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIG-DECALFEA--THGTAPKYAGQDKVNPGSII 357 N+ GD I+D A G P ++ + ++ H + AG + NP +I Sbjct: 252 ASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPVGMI 311 Query: 358 LSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L+A MML + G A+ + + + + G + + G+A+ E + Sbjct: 312 LAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGRP--CWSGGEQTADTAAIGEAVRECL 369 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 244 bits (622), Expect = 5e-63, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 134/346 (38%), Gaps = 55/346 (15%) Query: 49 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 108 +++ V+ + I W + + + + + L+ + ++ IKGP + Sbjct: 2 IESLVKVFSTVQVPIDWDVFH---EHKINSAEGEDVSPKLLESLCRNKIGIKGPFESGPC 58 Query: 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 168 LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 59 ------LRKLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 169 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 228 + IK + EG R+ R EYA N+R +T+ Sbjct: 110 PGVMQT-----------------------IKVSTAEGADRMARYVFEYAKKNNRKKITVA 146 Query: 229 HKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQ 288 HK NIM+ T+G F + A + +I+ ++ D Sbjct: 147 HKANIMRLTDGTFLSPMRREAAKY-------------------QDDIMFEERYLDTVCLA 187 Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQ 348 +L++P DV+ ++ GD ++ A+ +GG + PG +G ++E T AG+ Sbjct: 188 MLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPGFAVGPMGLIYEPIIHTNTNIAGK 247 Query: 349 DKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINA-KTVTYDF 393 D VNP ++LS +MLR M E AD I + T D Sbjct: 248 DIVNPTGMLLSGVLMLREMKLNEYADKICCAVSTVFRETDCRTKDL 293 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 243 bits (620), Expect = 9e-63, Method: Composition-based stats. Identities = 157/219 (71%), Positives = 183/219 (83%), Gaps = 1/219 (0%) Query: 2 ESKVVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60 K+ VPA G KIT+ + LNVP NPIIP+IEGDGIG+D++P M+KVVDAAV+KAY GE Sbjct: 3 YQKIQVPATGDKITVNADTSLNVPNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGE 62 Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120 RKISWME+Y GEK+TQVY QD WLP ETLD +++Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct: 63 RKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180 +LDLY+CLRPVR+++G PSPVK P DM IFRENSEDIYAGIEWKA S +A KVIKFL+ Sbjct: 123 QLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLK 182 Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 219 EEMGV KIRF + CGIG+KP S+EGTKRL R A+ A A Sbjct: 183 EEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 84/406 (20%), Positives = 150/406 (36%), Gaps = 56/406 (13%) Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76 + E ++ + G+G+G +V L ++ E G+R G ++ + Sbjct: 18 RGTGTERGEAFLVGVLPGEGVGPEVIDVALSLLRLLGEA--TGQRFEVRTGGPIGRQAER 75 Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + G+ L E D + L P GG LR+ DLY L P+R++ Sbjct: 76 LTGRG--LTPEVRDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPA 130 Query: 137 T-PSPVKHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 + V PE D++I REN+ +Y G EW ++ A + Sbjct: 131 LADAGVLRPEAARSADVLIVRENASGLYCG-EWGSEGEGAAR------------------ 171 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + + +R++R A+ A R + +V K + + D +A E Sbjct: 172 -SAYQVCRYRADEVERILRTALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGE- 228 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + + + D Q++ P ++DVI C N+ GD + D Sbjct: 229 -------------------HGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGDC 269 Query: 313 LAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWT 370 + +G G++ N G A+++ HG A AG+D+ NP + S MMLR Sbjct: 270 GSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLRESFRLP 329 Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + + + T D + + G A+ ++ Sbjct: 330 ALADALETAIARTLARGVRTADIQGA--QPTAVGTRAMGQALCASL 373 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 240 bits (612), Expect = 9e-62, Method: Composition-based stats. Identities = 93/397 (23%), Positives = 151/397 (38%), Gaps = 71/397 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 I + GDGI +++ A+ V DA +I ++ + ++S + G ++ Sbjct: 7 NRYSIVELHGDGIARELSQAVHTVADALP-------FEIEFIPVDLSDESREAKGDAIY- 58 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 E +R Y ++K P T S N LR+ + + RPV G + + Sbjct: 59 -DEAEAAMRRYGTSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQT--HYN 111 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 E + I R + Y R + I+ Sbjct: 112 ERIHLDIVRIATGGTY-----------------------EDAGRRINRDTAVSIRAIERR 148 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 + R A A D +V K I K T+G F++ +AR+ Sbjct: 149 PSVLASRFAFRLAQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDY------------ 195 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 ++ + DA L I++RP Y VI C N GD++SD +G IG+ Sbjct: 196 --------PATEFREELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGLIGSIGLGD 247 Query: 325 GANIGDE------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVK 378 A+ + A+F+ GTAP AGQ+K NP + +L+ MLRH+G +++ + Sbjct: 248 SASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAMANMLRHIGEHDSSKALRG 307 Query: 379 GMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + GAI A T D L SEF I++ Sbjct: 308 ALFGAIEAGEKTADI------GGSLNLSEFTQVIVDR 338 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 234 bits (597), Expect = 4e-60, Method: Composition-based stats. Identities = 80/415 (19%), Positives = 143/415 (34%), Gaps = 79/415 (19%) Query: 18 NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 NGK P + IEG G G V A+ K+ AA+ + W Sbjct: 34 NGKAQRP--IRVTVIEGQGTGPVVLAAVRKIFKAAL-------VPVEWDYQTLSVYRDHK 84 Query: 78 YGQDVWLPAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG 136 + P LD E + + ++P + S ++AL + L+ ++ +R G Sbjct: 85 TNRMTVNPQ-LLDSAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG 143 Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196 + ++V RE+ Y+ IE + Sbjct: 144 ----HEPYGPINLVNIREHVSGEYSEIEHLVSPGVVQ----------------------- 176 Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256 IK S++ + + + A +YA + +T++HK ++M+ ++G F +++ Sbjct: 177 SIKTVSKKISVEVAKLAFDYACKHGHSRITVLHKADVMRLSDGIFLKACREVSACY---- 232 Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316 ++ + D+F + P Y+V+ +L G + Sbjct: 233 ----------------PDVEYNEEKLDSFCLNVTTNPGRYEVLLTTSLYGAFAGSVCGMM 276 Query: 317 VGGIGIAPGANIGDECALFEA---------THGTAPKYAGQ------DKVNPGSIILSAE 361 GG+ P G + +F +H + +NP II +A Sbjct: 277 SGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYGQEQIINPTGIIRAAA 336 Query: 362 MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +ML H G A I +E I T D CS+F DAII+N+ Sbjct: 337 LMLDHAGMVVAGRCIAAAVEDTIRQGIRTQDM------GGDASCSQFTDAIIKNL 385 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 87/416 (20%), Positives = 142/416 (34%), Gaps = 78/416 (18%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I DG+G DV P K + A E E + E G + G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE--AGVEYAVKTGK--MC 57 Query: 85 PAETLDLIREYRVAIKGPLTT----------PVGGGIRSLNVALRQELDLYICLRPVRYY 134 + I + + G P + LR + I LRP+R Sbjct: 58 EDNLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLR 117 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 +G P+++ E D+++ R+ +E Y E Sbjct: 118 KGIDCPLRNREEIDVLLVRQLAEGFYIRPGH-----------------------MIGEDA 154 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHK-GNIMKFTEGAFKDWGYQ 247 + T++ A + VTL +K GN+ F ++ + Sbjct: 155 AYDTIVVTRNVTEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCF--DFYRKIFTE 212 Query: 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGD 307 ++ +I ++ DA + ++ P +DVIAC N+ GD Sbjct: 213 VSAGY--------------------PDIGLQFTQVDALAEHLIKDPDRFDVIACENMIGD 252 Query: 308 YISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM 367 I D A GG+GI P A++G F HGT P+ G+ NP + IL+A ++L + Sbjct: 253 IIGDIGAYITGGMGITPTADVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTL 312 Query: 368 G-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G A LI K +E + T R D +A+ + M Sbjct: 313 GNERGDDNLRRGARLIEKAVEYNL-----TTGGPRTKDLGGTANTFATAEAVFKAM 363 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 82/435 (18%), Positives = 150/435 (34%), Gaps = 74/435 (17%) Query: 25 ENPIIP--YIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + +E DG M +++ EK I G + Sbjct: 42 KRIKVAKPVVEMDG------DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV- 131 V + ++ ++Y VA+K TP + +S N +R L + P+ Sbjct: 96 VTI--DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 153 Query: 132 -----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 R G P + I R D Y ++ AD A K++ ++ GVK Sbjct: 154 CKNIPRLVPGWTKP--------ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVK 205 Query: 187 KIRFPEHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 + G+ ++E + +YAI + + + K I+K +G FKD Sbjct: 206 EWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKD 264 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ + + + W + + D + Q+L + V AC N Sbjct: 265 IFQEIFDKHYKTDFDKNKIW-------------YEHRLIDDMVAQVLKSSGGF-VWACKN 310 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNPGS 355 +GD SD LA G +G+ + + EA HGT ++ + + NP + Sbjct: 311 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 370 Query: 356 IILSAEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL----- 403 I + L H G + A ++ K + + +T D + G + Sbjct: 371 SIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEH 430 Query: 404 --KCSEFGDAIIENM 416 ++F D I N+ Sbjct: 431 FLNTTDFLDTIKSNL 445 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 224 bits (572), Expect = 4e-57, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 129/362 (35%), Gaps = 73/362 (20%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 I I GDGIG +V A +A E ++W V + Sbjct: 16 YKIAAIRGDGIGPEVIEAGNY--QSAEETNRVAWILLNWPSRTLSGA--------VRITR 65 Query: 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 146 T D+ P+++ S + LR + P R + G SP+ Sbjct: 66 NTADI---------SPISSSTFLWFSSY-LPLRSS---TSNM-PTRVFHGIQSPLH---- 107 Query: 147 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 D VI RENSE YAG G P I + G Sbjct: 108 LDWVIVRENSEGEYAGHG-------------------GRSYAGKPWEVATDISIFTRHGV 148 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 +R+++ A E A + + +T+ K N + + ++A E + Sbjct: 149 ERIMKFAFEAARSRAKKHITVATKSNAQRNGLVVWD----EIAAAEVAAQF--------- 195 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 ++ ++ DA +++L P D I NL+ +SD +A G IGIAP + Sbjct: 196 ------PDVTCDKMLVDAMTARVVLTPESLDTIVPTNLHAGILSDLASALAGSIGIAPTS 249 Query: 327 NIGD---ECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N+ ++FE HG+A AG+D + ML +G AA +++ +E Sbjct: 250 NLDPTRENPSMFEPVHGSAFDIAGKDLA----TFWTVAEMLSWLGQKGAAAELLECVESV 305 Query: 384 IN 385 Sbjct: 306 CK 307 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 77/404 (19%), Positives = 131/404 (32%), Gaps = 90/404 (22%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I GD G +V +KV+ A + K + E G S +V+ + Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAK 61 Query: 86 AETLDLIREYRVAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQGT--- 137 A + + G + P G + LR+EL Y LRP + + Sbjct: 62 ALAAAKAADAILL--GAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVD 119 Query: 138 PSPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 195 SP+K TD ++ RE + IY G + D + Sbjct: 120 SSPLKADVCRGTDFIVVRELTGGIYFGARTEDDGSG----------------------FA 157 Query: 196 IGIKPCSEEGTKRLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 254 + S +R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 158 MDTDAYSRAEIERIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF- 215 Query: 255 GELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDAL 313 ++ + + D+ ++ P + V+ NL GD ISD Sbjct: 216 ------------------PQLEVGHQLIDSAAMLMVKSPRALNGVVVTSNLFGDIISDEA 257 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEA 372 + G IG VNP ILS MMLR+ + + Sbjct: 258 SVIPGSIG--------------------------AGIVNPIGTILSVAMMLRYSLNLPKE 291 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A + + A++ T T D + DA++ + Sbjct: 292 AAAVEAAVRTALDNGTRTKDL------GGSAGTFQMADAVVVEL 329 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 93/388 (23%), Positives = 149/388 (38%), Gaps = 52/388 (13%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + +G+GIG ++ ++ V+ A++ GE ++ + G ++ G+ V P E Sbjct: 8 RLGVWQGEGIGPEIVAPTVQAVELALQA--SGEATPEFVPLLLGREAINATGRIV--PEE 63 Query: 88 TLDLIREYRVAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 143 T + I I GP P G + + LR++ DL+ +RPVR G P Sbjct: 64 TWETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP--- 120 Query: 144 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 203 D+VI REN+E +YA S D + + + Sbjct: 121 --DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAI--- 175 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 A +T+ HK N++ T G + A E Sbjct: 176 --------------AAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF----------- 210 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + ++ V DA +++ RP Y I N+ GD +SD G +GIA Sbjct: 211 ----------GVEVQPVHIDALCAELVTRPERYATIVAENMFGDILSDLAGGLGGSLGIA 260 Query: 324 PGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGA 383 N + + +A HG+AP AGQ NP I+ SA ML +G+ +AA+L+ + A Sbjct: 261 GSINASESQVMAQAAHGSAPDIAGQGIANPAGIMNSAAQMLDSLGYPQAAELLEGAVREA 320 Query: 384 INAKTVTYDFERLMDGAKLLKCSEFGDA 411 + K T D R A + D Sbjct: 321 VV-KAPTADLVREAAAADPETATPVADE 347 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 218 bits (554), Expect = 4e-55, Method: Composition-based stats. Identities = 79/433 (18%), Positives = 145/433 (33%), Gaps = 64/433 (14%) Query: 19 GKLNVPENPII--PYIEGDGIGVDVTPAMLKVVDA-AVEKAYKGERKISWMEIYTGEKST 75 K++ + + P +E DG M +V+ A EK I M + Sbjct: 174 NKMSGFQRIKVDQPVVEMDG------DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHR 227 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYI 126 V + + I+ + V +K TP ++ S N +R LD I Sbjct: 228 DKTDDQVTI--DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTI 285 Query: 127 CLRPV--RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184 P+ + P ++I R D Y +++ D + ++ Sbjct: 286 FRAPILMKNVPRLVPSWTKP----IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSN 341 Query: 185 VKKIRFPE--HCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241 + E G+ + ++ K + +YA+ + L K ++K +G F Sbjct: 342 PEVHEVYEFKGGGVALGMYNTDASIKGFAHSCFQYALDQKM-PLYLSTKNTVLKKYDGRF 400 Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301 KD + +E+ + + G W + + D + Q + + V AC Sbjct: 401 KDIFQTIYEKEYKQKFEEAGLW-------------YEHRLIDDMVAQAIKSSGGF-VWAC 446 Query: 302 MNLNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYAGQDK------VNP 353 N +GD SD +A G +G+ + + EA HGT ++ Q + NP Sbjct: 447 KNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTSTNP 506 Query: 354 GSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK-- 404 + I + L H E + + + A +T D + G KL Sbjct: 507 IASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRD 566 Query: 405 ---CSEFGDAIIE 414 +F D + Sbjct: 567 YLCTEDFMDKLAR 579 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 82/434 (18%), Positives = 145/434 (33%), Gaps = 76/434 (17%) Query: 28 IIPY----IEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 I +E DG M +V+ + +K ++ G V Sbjct: 5 KITVQNPIVEMDG------DEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKV 58 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV-- 131 + E+ + ++Y VAIK TP + RS N +R L+ + P+ Sbjct: 59 TV--ESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMC 116 Query: 132 ----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR---EEMG 184 R G P + I R D Y + A K++ E+ Sbjct: 117 KNIPRLVPGWTKP--------ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTE 168 Query: 185 VKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 + F G+ + + + + R A++ A + + L K I+K +G FKD Sbjct: 169 FEVYNFTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKD 227 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ + + + G W + + D + L Y V AC N Sbjct: 228 IFQEVYEANWKSKYEEAGIW-------------YEHRLIDDMVAYALKSEGGY-VWACKN 273 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECAL--FEATHGTAPKYA------GQDKVNPGS 355 +GD SD LA G +G+ + + EA HGT ++ G+ N + Sbjct: 274 YDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIA 333 Query: 356 IILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK---- 404 I + L H + + + GA+ + +T D ++ L Sbjct: 334 SIFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHY 393 Query: 405 --CSEFGDAIIENM 416 EF DA+ + + Sbjct: 394 LNTEEFIDAVADEL 407 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 214 bits (546), Expect = 4e-54, Method: Composition-based stats. Identities = 66/411 (16%), Positives = 139/411 (33%), Gaps = 58/411 (14%) Query: 43 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 101 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV--TKDAAEAIKKHNVGVKC 73 Query: 102 PLTTPVGGGI---------RSLNVALRQELDLYICL--RPVRYYQGTPSPVKHPELTDMV 150 TP + +S N +R L + + S P ++ Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP----II 129 Query: 151 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI---RFPEHCGIGIKPCSE-EGT 206 I R D Y ++ ++ + F E G+ + ++ + Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 + ++ + A++ + L K I+K +G FKD ++ +++ + W Sbjct: 190 EDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW--- 245 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + + D + Q + + + AC N +GD SD++A G +G+ Sbjct: 246 ----------YEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLGMMTSV 294 Query: 327 NIGDECAL--FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGWTE------- 371 + + EA HGT ++ + NP + I + L H + Sbjct: 295 LVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAF 354 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLL------KCSEFGDAIIENM 416 A+ + + I A +T D + G + EF D + EN+ Sbjct: 355 FANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENL 405 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 211 bits (537), Expect = 5e-53, Method: Composition-based stats. Identities = 81/408 (19%), Positives = 141/408 (34%), Gaps = 78/408 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 P I + GD G ++ L+V+ +V + + +++ ++ + V Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIRQ-----PLQFLDYDLSLENRRATDNKVV-- 57 Query: 86 AETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQ------GTP 138 E R+ +++K TP G + S N LR+ L+ + LR R G Sbjct: 58 WEAAQAARDSGLSLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVY 117 Query: 139 SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 SP + I R +D Y EW+ + + Sbjct: 118 SP--------IAIVRMAVDDAYGSKEWRETTE-------------------NGDEIAYRT 150 Query: 199 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S + + +YA + V K + EG FK+ A+ Sbjct: 151 SKISRSTCRAVAEFTFQYA-KRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRY------ 203 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 E+ + ++ DA +L E VI +N +GD +SD + G Sbjct: 204 --------------PEVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDMVLQMYG 249 Query: 319 GIGIAPGANIGDECA-------LFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT- 370 I + +G E + EA HGTAP G++ NP ++IL+ +L + Sbjct: 250 SIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLSYGRIPQ 309 Query: 371 --EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +A+ I + + I T D + SEF D +I + Sbjct: 310 AEKASRAIYESVFETIYEGKATPDL------GGQMTTSEFTDEVIRRV 351 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 211 bits (536), Expect = 6e-53, Method: Composition-based stats. Identities = 85/408 (20%), Positives = 140/408 (34%), Gaps = 68/408 (16%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +PE I +EGD G ++ ++V+D + ++ + V Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGV 55 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 ++ +R IK TP G + S N LR+E+D + +R R G Sbjct: 56 V--SDAAAAMRTCGFGIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIA 113 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + I R ED Y +W+ A A + + Sbjct: 114 GVHYP--ISIVRMAIEDAYGAKQWREGDAGAA------------------DEVAYRTEHV 153 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + + A A A + V K + EG K+ A Sbjct: 154 TRSTCRAVSEYAFRTARAM-QARVYGGPKWTVSPVYEGMLKEEMDAAAAR---------- 202 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILL-RPAEYDVIACMNLNGDYISDALAAQVGGI 320 ++ + V+ DA ++ E V+ +N +GD +SD + G I Sbjct: 203 ----------HPDVAYEPVLIDATYAGLVSGAADEPLVVPALNRDGDCLSDLVLPMFGSI 252 Query: 321 GIAPGA------NIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM------G 368 A N A+ EA HGTAP G+D NP +++L++ +LRH G Sbjct: 253 AGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVANPMAMLLASGAVLRHAAERGHPG 312 Query: 369 WTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A+ I + + AI T D +EF DA+IE + Sbjct: 313 AERASRAIYESVLEAIATGIKTPDL------GGHAGTTEFTDAVIERI 354 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 63/383 (16%), Positives = 128/383 (33%), Gaps = 62/383 (16%) Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQE 121 G + V + E + I++Y V +K TP + S N +R Sbjct: 101 GIEYRDQTDDKVTV--EAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNI 158 Query: 122 LDLYICLRPV------RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKV 175 L + P+ R G P ++I R D Y + ++ Sbjct: 159 LGGTVFREPIVIPAIPRLVPGWTKP--------IIIGRHAFGDQYRATDRVIPGPGKLEL 210 Query: 176 IKFLREEMG--VKKIRFPEHCGIGIKPC-SEEGTKRLVRAAIEYAIANDRDSVTLVHKGN 232 + V+ F G+ + +++ + ++ + A+ + + K Sbjct: 211 VYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNT 269 Query: 233 IMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR 292 I+K +G FKD ++ E+ E G W + + D + Q++ Sbjct: 270 ILKRYDGRFKDIFQEIYEAEYKKEFDAKGIW-------------YEHRLIDDMVAQMIKS 316 Query: 293 PAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQDK 350 + ++A N +GD SD +A G +G+ + + F EA HGT ++ + + Sbjct: 317 EGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQ 375 Query: 351 ------VNPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAI-NAKTVTYDFERL 396 NP + I + L G + A+ + + + +T D Sbjct: 376 KGRETSTNPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALS 435 Query: 397 MDGAKL---LKCSEFGDAIIENM 416 + + E+ A+ + Sbjct: 436 CGRKEREAWVTTREYMAAVERRL 458 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 204 bits (519), Expect = 4e-51, Method: Composition-based stats. Identities = 72/403 (17%), Positives = 130/403 (32%), Gaps = 74/403 (18%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 86 + + GDG+G +V +++ E+ G ++ G LPA Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVE----VTGPWPVGARAAAETGD--VLPA 55 Query: 87 ETLDLIREYRVAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTPSP 140 TL + G + P G R LR+ DL I +R Sbjct: 56 GTLAACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVR----------E 105 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + + ++ + R Y G + + D + + Sbjct: 106 IPFADGRELTVVRNLIGGSYGGADDRVLREDGSE--------------------AADVLR 145 Query: 201 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDG 260 + E +V A + + V K N + T ++ +ARE Sbjct: 146 LTRERVAEVVHTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARE--------- 195 Query: 261 GPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320 + I ++ D ++ DV+ L GD +SD A + G Sbjct: 196 ------------RGIEVEHRYVDRAAFELGSGAPVPDVLVTEGLLGDILSDLAAGRAGSP 243 Query: 321 GIAPGANIGDE-------CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAA 373 + A++ LFE HG+AP+ A +D+V+P L+ +LRH T A Sbjct: 244 ALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPLGGFLALAALLRHFPATREA 303 Query: 374 -DLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 + + + + + TYD +G + DA++ Sbjct: 304 GERVRAAVGAVLRSGPWTYDLV--PEGGAAASTGQVADAVLAA 344 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 69/395 (17%), Positives = 128/395 (32%), Gaps = 68/395 (17%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + + GDG G + + + +D K+S + G L Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDF---GGVALAAGAGTAL 64 Query: 85 PAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG--TPSPV 141 P+ TL R+ + P G + LRQEL+ + +RPVR+ Sbjct: 65 PSTTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 142 KHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 PE+ D+ FR+ + +Y G +A + Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAG----------------------DDGEAYDT 162 Query: 199 KPCSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 P S + +R+ R A YA+ + V + K N+M T ++ + EF Sbjct: 163 TPYSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF---- 217 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYD-VIACMNLNGDYISDALAAQ 316 ++ ++ V+ D + P + +I N+ GD +SD Sbjct: 218 ---------------PQVPLRHVLVDTASMILSSDPLSLNGIILTENMFGDILSDQAGGI 262 Query: 317 VGGIGIAPGANIGD--------ECALFEATH-GTAPKYAGQDKVNPGSIILSAEMMLR-H 366 +G + A + +FE + K G P I + +ML Sbjct: 263 LGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNPGGKTVG-----PLGSIQAVGLMLELS 317 Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK 401 +G ++ + K + ++ + R +D Sbjct: 318 LGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 80/395 (20%), Positives = 133/395 (33%), Gaps = 103/395 (26%) Query: 23 VPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV 82 +P + I +VT A+ +V+DA Y E Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQAPVYF-------------ETYIIKGKNMN 40 Query: 83 WLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK 142 L E +D IR+ +V + G + + GG R+ELDL+ L G PS Sbjct: 41 HLTWEVVDSIRKNKVCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS--- 90 Query: 143 HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 E D+V+ REN+E YAG E + E + Sbjct: 91 RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT----------------------MT 128 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 + + R+ + A EYA + R VT VH G K + F + ++A+ Sbjct: 129 KFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMY--------- 179 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 I + + + + R + + I++ + GG Sbjct: 180 -----------PNITYNE--IASRETRAIRRHSNSKSLWA------IIANIASGVAGG-- 218 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + GD+ A+FE + NP +++ S+ MMLRH+ AD + + Sbjct: 219 -----SFGDDYAIFEQVGSVG------NHKNPVALLFSSVMMLRHLLLPLFADRLKTAVT 267 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 I+ G E D++I N+ Sbjct: 268 RVISEGKC---------GNSNTTTQEVVDSVIANL 293 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 58/182 (31%), Positives = 82/182 (45%), Gaps = 25/182 (13%) Query: 235 KFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPA 294 + ++G F +A++ EI ++ D ++ P Sbjct: 112 RMSDGLFLRCVRDMAQKF--------------------PEIQFEEKYLDTVCLNMVQNPG 151 Query: 295 EYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPG 354 +YDV+ NL GD +SD A VGG+G+ P N+G ALFE+ HGTAP AG+D NP Sbjct: 152 KYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPT 211 Query: 355 SIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 +++LSA MMLRHM AD I + I D KCSEF + I Sbjct: 212 ALLLSAVMMLRHMELNTYADKIERAAFETIKEGK-----YLTGDLGGRAKCSEFTNEICA 266 Query: 415 NM 416 + Sbjct: 267 KL 268 Score = 57.0 bits (136), Expect = 1e-06, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 21/57 (36%), Gaps = 7/57 (12%) Query: 14 ITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 T + + I GDGIG +++ A+ K+ AA I W + Sbjct: 35 ATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDV 84 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 191 bits (486), Expect = 4e-47, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 111/303 (36%), Gaps = 62/303 (20%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 +N P I I GDGIG ++ + ++V+ AA + + ++ + G + + G Sbjct: 1 MNAPHALDIAVIPGDGIGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTG- 55 Query: 81 DVWLPAETLDLIR-EYRVAIKGPLTTP-----VGGGIRSLNVALRQELDLYICLRPVRYY 134 + A TL+ IR Y +KGP+ P G L LR LD Y +RP+ Sbjct: 56 -SAMSAATLERIRTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALL 114 Query: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 194 G +P++ D VI REN+E +Y + Sbjct: 115 PGVDAPLRG-TAVDYVIVRENTEGLYLSRGRGVG----------------------NDRA 151 Query: 195 GIGIKPCSEEGTKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQL 248 + G +R+V A E A VT V K N+++ + F++ ++ Sbjct: 152 CADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEV 210 Query: 249 AREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDY 308 A ++ ADA ++ P +DV+ N GD Sbjct: 211 ATRY--------------------PQVEADHRYADAAGHDLVADPGRFDVLVMENFLGDI 250 Query: 309 ISD 311 +SD Sbjct: 251 LSD 253 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 190 bits (482), Expect = 1e-46, Method: Composition-based stats. Identities = 77/431 (17%), Positives = 140/431 (32%), Gaps = 88/431 (20%) Query: 25 ENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQD 81 + + P +E DG M +V+ +K + G + Sbjct: 79 DRVKVQNPIVEMDG------DEMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDK 132 Query: 82 VWLPAETLDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV- 131 V + E+ + +Y VA+K TP + RS N +R L+ + P+ Sbjct: 133 VTV--ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPIL 190 Query: 132 -----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 R G P + I R D Y + K+I + Sbjct: 191 CLNIPRIVPGWKKP--------ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPL 242 Query: 187 KIRFPE--HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 ++ + G+ + + + + R +++ A A + + L K I+K +G FKD Sbjct: 243 ELDVYDFKGPGVALAMYNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKD 301 Query: 244 WGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303 ++ E++ + + W + + D + + Y V AC N Sbjct: 302 IFQEVYEEKWKQKFEEHSIW-------------YEHRLIDDMVAYAVKSEGGY-VWACKN 347 Query: 304 LNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYA------GQDKVNPGSII 357 +GD SD + EA HGT ++ + N + I Sbjct: 348 YDGDLSSD------------------GKTLEAEAAHGTVTRHFRLFQKGQETSTNSIASI 389 Query: 358 LSAEMMLRHM-------GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKL-----LKC 405 + L H G + + + A +T D L+ G K+ L Sbjct: 390 FAWTRGLEHRAKLDKNEGLLDFVHKLEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNT 449 Query: 406 SEFGDAIIENM 416 EF DA+ +N+ Sbjct: 450 EEFIDAVAQNL 460 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 187 bits (474), Expect = 9e-46, Method: Composition-based stats. Identities = 91/404 (22%), Positives = 179/404 (44%), Gaps = 52/404 (12%) Query: 13 KITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I L L +P++ I YIEGDG G ++T AM+ V++A+E AY G + I W +IY G Sbjct: 2 YIKLDGNHLIIPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGR 61 Query: 73 KSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVR 132 ++ + YG+ +LP E+++ IR+ +KGPL++ + G +N+ +++ L+LY ++ + Sbjct: 62 EAYEKYGK--YLPRESIEDIRKTVFVMKGPLSSNING--HDININIKRILNLYTDVKCIT 117 Query: 133 YYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 G E ++ IF + +++Y + DS D++ + ++L++ + Sbjct: 118 GLPGLS------EGKEIFIFSPSIDEVY---HFSYDSEDSDMLRQYLQQSFNIS---IGG 165 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 I +K S R+++ A + A + L ++ Sbjct: 166 DSDIFLKGTSRY---RIIKIASKIAEISS-------------------LYGIKRTLVADD 203 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 + G + + EI + D + + +++ + I Sbjct: 204 YTGSHAPLWVYNTLNKMEMPVEIENLYNLYDEMTSE-----SRFNIFIPDSRLSSLIIKI 258 Query: 313 LAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEA 372 + A+ GA +GD +LFE+ + G D +P S +L++ MMLR + + +A Sbjct: 259 INART-----FFGAILGDFISLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDA 313 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A ++ + + + + LKCS+F DAI++ M Sbjct: 314 ALILRNALNSVYSDGILPASL----NLNNGLKCSDFIDAIVKRM 353 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 184 bits (467), Expect = 5e-45, Method: Composition-based stats. Identities = 68/415 (16%), Positives = 141/415 (33%), Gaps = 53/415 (12%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ ++ + G V + ++ Sbjct: 41 PLVEMDG------DEMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQVTV--DS 92 Query: 89 LDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPVRYYQGTPS 139 + + VA+K TP + +S N +R LD + P+ +G Sbjct: 93 AEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRGID- 150 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK--IRFPEHCGIG 197 P + + + R D+Y E + +++ + ++ F E + Sbjct: 151 PCVKNWVRPITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVVE 210 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 + + RA ++A+A +D V K I K + FKD ++ ++ Sbjct: 211 GMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAARF 269 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 G I + D + +++ + + AC N +GD +SD +++ Sbjct: 270 EAAG-------------IEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAF 315 Query: 318 GGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKV------NPGSIILSAEMMLRHMGWT 370 G + + +EA HGT ++ + N + I + LR Sbjct: 316 GSLAMMTSVLASPHGYWEYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAEL 375 Query: 371 E-------AADLIVKGMEGAINAKTVTYDFERL--MDGAKLLKCSEFGDAIIENM 416 + AD + + I + +T D R+ ++ L F A+ E++ Sbjct: 376 DGLADLAAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDL 430 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 177 bits (450), Expect = 5e-43, Method: Composition-based stats. Identities = 71/418 (16%), Positives = 130/418 (31%), Gaps = 95/418 (22%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ +K I G + V L + Sbjct: 15 PVVELDG------DEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTL--DA 66 Query: 89 LDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPS 139 + I++Y V +K TP + S N +R L + P+ P Sbjct: 67 AEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPAIPR 125 Query: 140 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR--EEMGVKKIRFPEHCGIG 197 V + ++I R D Y + D+ +++ + + +K FP G+ Sbjct: 126 LVPSWKQ-PIIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKGGKPEVIKVYDFPAEGGVA 184 Query: 198 IKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 FKD ++ ++ E Sbjct: 185 QT----------------------------------------QFKDIFQEIYEAQYRKEF 204 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQV 317 G W + + D + Q++ Y +IA N +GD SD +A Sbjct: 205 EAAGIW-------------YEHRLIDDMVAQMIKSEGGY-IIAMKNYDGDVQSDIVAQGF 250 Query: 318 GGIGIAPGANIGDECALF--EATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMGW 369 G +G+ I + F EA HGT ++ + + NP + I + L G Sbjct: 251 GSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQKGRETSTNPIASIYAWTQGLIKRGE 310 Query: 370 TE-------AADLIVKGMEGAI-NAKTVTYDFE---RLMDGAKLLKCSEFGDAIIENM 416 + A+ + K + +T D D + + +E+ DA+ + Sbjct: 311 LDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQGKKDRSAWVTTNEYLDAVERRL 368 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 173 bits (438), Expect = 1e-41, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 122/416 (29%), Gaps = 61/416 (14%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 97 G ++T ++ ++ A + W E K+ V + ++ + + Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTA--WREFDLRAKNRDDTEDQVL--RDVIEAGKAVKA 73 Query: 98 AIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 K P TP ++ S N A+R+ + R + G K P + Sbjct: 74 IFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE 133 Query: 149 MVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 202 R YA G + + + + + Sbjct: 134 ----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNP 189 Query: 203 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGP 262 + L R + +V K + K+ E + ++ EE+ + +D G Sbjct: 190 YDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFW-QIMKKVFDEEYKSKFVDAGV 247 Query: 263 WLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGI 322 + +++DA +++ +A N +GD ++D LA G Sbjct: 248 MKSGD--------ELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGF 299 Query: 323 APGANIG--DECAL---FEATHGTAPKY------AGQDKVNPGSII--LSAEMMLRHMGW 369 +G + L FEA+HGT + +NP ++ L M H Sbjct: 300 ITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAM--NHAAD 357 Query: 370 TE---------AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + T D L +F DA+ E + Sbjct: 358 VHNVDKERTLAFTAKMRAVIHQLFREGKGTRDLSGPS----GLTTEQFVDAVAERL 409 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 172 bits (435), Expect = 3e-41, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 122/337 (36%), Gaps = 55/337 (16%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRF---P 161 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 206 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLK 265 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDYCS---------- 248 Query: 266 VKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPG 325 I ++ + D + +++ PA +D I + +++ + GG + Sbjct: 249 ---------IKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSA 299 Query: 326 ANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIN 385 +GD A+F+ T ++P I+ + +L H+G A + KGM + Sbjct: 300 IELGDSHAVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQESCAKSLWKGMLRTMT 358 Query: 386 AKTVTYDFERL-------MDGAKLLKCSEFGDAIIEN 415 T +F+ + L+CS G+ + + Sbjct: 359 DGIKTVEFDGPDTGEYVICNIMNKLRCSALGENVEKK 395 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 169 bits (429), Expect = 2e-40, Method: Composition-based stats. Identities = 52/129 (40%), Positives = 69/129 (53%), Gaps = 6/129 (4%) Query: 289 ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAG 347 ++ P+++DV+ NL GD +SD A +GG+G+ P NIG A+FE+ HGTAP AG Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAG 89 Query: 348 QDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407 +D NP +++LSA MMLRHMG A I I K V D KCSE Sbjct: 90 KDMANPTALLLSAVMMLRHMGLHGHAKKIETACFDTIRDKKV-----LTKDLGGNPKCSE 144 Query: 408 FGDAIIENM 416 F I + Sbjct: 145 FTADICRRV 153 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 169 bits (427), Expect = 2e-40, Method: Composition-based stats. Identities = 58/426 (13%), Positives = 123/426 (28%), Gaps = 72/426 (16%) Query: 38 GVDVTPAMLKVVDAAVEKAYKGERKIS-WMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 G ++T +++ + + + IS W K+ + + ++ + Sbjct: 89 GEEMTHYATQLL---LNQWIEPYFDISSWETFDLSCKARDDSDDATLI--DAVEAGKRIG 143 Query: 97 VAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 K P TP ++ S N A+R+ + R + +G K+ L Sbjct: 144 AIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQVLF 203 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC----GIGIKPCSE 203 + R Y G W ++ + + + Sbjct: 204 E----RHAVGGEY-GAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPY 258 Query: 204 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPW 263 + + L + + + +V K + K+ EG + ++ + + E + G Sbjct: 259 DNVRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFW-ATMKRVFDDTYKDEFLKAGLL 316 Query: 264 LKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + + +I+DA Q++ +A N +GD ++D +A G Sbjct: 317 DRSGG-------ELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFI 369 Query: 324 PGANIG---DECAL---FEATHGTAPKYAGQDKV------NPGSII--LSAEM------- 362 +G D L FEA+HGT NP ++ L M Sbjct: 370 TSNLVGVSDDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLE 429 Query: 363 ------------MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGD 410 M ++ + + + T D +F Sbjct: 430 YDAKPNDVEAKRMYEYV--NNFTNTLRMALHNTFRYGQGTRDMCGP----TGFTTEDFIA 483 Query: 411 AIIENM 416 + + Sbjct: 484 KVAWRL 489 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 167 bits (422), Expect = 1e-39, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 121/332 (36%), Gaps = 54/332 (16%) Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 144 + + + R A+ + V + ++ L +LDLY+ VR + G Sbjct: 97 TDDFYNSVLRNRSAV--HVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRF--- 151 Query: 145 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 204 ++ I +N+ +Y+ +E+ E I ++E Sbjct: 152 PDVNIRIIAQNNMGVYSDLEYSPVKGVVE-----------------------AISVSTQE 188 Query: 205 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWL 264 G ++ +R A A+ +R VTL+HK T+GA ++ ++ Sbjct: 189 GNEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHC--------- 239 Query: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 + ++ + + + +++ P E+D I + I+ + GG + Sbjct: 240 ----------LELELMNVEDCIGRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFS 289 Query: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 IGD A+F+ ++P I+ + + H+G+TE D + + M + Sbjct: 290 AVEIGDFHAVFKPLQ-VKLSLTNYPILSPYGIVNTIVDLFDHLGYTECGDALWEQMLRTM 348 Query: 385 NAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + T DF D + + C+ II + Sbjct: 349 ESGIKTKDFGGE-DSGEYVICN-----IINRL 374 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 157 bits (398), Expect = 5e-37, Method: Composition-based stats. Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 13/185 (7%) Query: 2 ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGER 61 + + A +L P+ + G G+G +++ A+ + +AA + Sbjct: 8 YASSAIRATASPRSLSTSASTSPQ-FTVTLFPGHGVGPEISVAVQNIFNAA-------DV 59 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 121 I W E + + A+ LD +R R +KGP+ TP+G G RSLN+ LR+ Sbjct: 60 PIVWDEHHIDVD--NAKPGQDLISADALDSLRRNRFGLKGPMATPIGKGYRSLNLTLRKA 117 Query: 122 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 181 L LY +RP G +P + D+V REN+E Y+G+E E + E Sbjct: 118 LGLYANVRPCVSIPGVQTPY---DDVDVVTVRENTEGEYSGLEHVVYPGVVESLKVITPE 174 Query: 182 EMGVK 186 + + Sbjct: 175 RVNAR 179 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 157 bits (397), Expect = 7e-37, Method: Composition-based stats. Identities = 77/462 (16%), Positives = 131/462 (28%), Gaps = 129/462 (27%) Query: 30 PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 P +E DG M +++ +K + G + V + E+ Sbjct: 66 PIVEMDG------DEMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVTV--ES 117 Query: 89 LDLIREYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPV------RY 133 + +Y VA+K TP + RS N +R L+ + P+ R Sbjct: 118 AEATLKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCXNVPRI 177 Query: 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE- 192 G P + I R D Y + + K++ ++ + Sbjct: 178 VPGWKKP--------ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDF 229 Query: 193 -HCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250 GI + + + + R +++ A A + + L K I+K +G Sbjct: 230 KGPGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG----------- 277 Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310 + + D + L Y V AC N +GD S Sbjct: 278 -------------------------RYEHRLIDDMVAYALKSDGGY-VWACKNYDGDVQS 311 Query: 311 DALAA---------------------------------QVG----GIGIAPGANIGDECA 333 D LA G I I+ D Sbjct: 312 DLLAQGFLLHMRNERSDYPVXLHLVKSYPILFVLSRIRFFGSYDFSIAISGKQLSSDGKT 371 Query: 334 L-FEATHGTAPKYAGQDK------VNPGSIILSAEMMLRHMG-------WTEAADLIVKG 379 L EA HGT ++ Q + N + I + L H + + Sbjct: 372 LEAEAAHGTVTRHFRQYQKGLETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVHKLEAA 431 Query: 380 MEGAINAKTVTYDFERLMDGAKL-----LKCSEFGDAIIENM 416 + + +T D L+ G K L EF D + N+ Sbjct: 432 CIETVESGNMTKDLAILIHGPKASXEFYLNTEEFIDTVAHNL 473 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 95/321 (29%), Gaps = 63/321 (19%) Query: 104 TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGI 163 P + LR+E+ Y +RP + + + P+ G+ Sbjct: 36 GAPATSRPERGLLKLRKEMGTYGSMRPCFFASDS---LVAPQG--------------RGV 78 Query: 164 EWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRD 223 A ++L + + + +P S +R A Sbjct: 79 PRHRLCHCARAHRRYL-----LWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDK 133 Query: 224 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIAD 283 + + N++ T ++ + +EF ++ ++ + + Sbjct: 134 KLWSLDNANVL-ATSRFWRKVMTETFEKEF-------------------PDLKVEHQLIN 173 Query: 284 AFLQQILLRPAEYD-VIACMNLNGDYISDALAAQVGGIGIAPGANIG-------DECALF 335 + + ++ P + V+ L GD ISDA IG+ P A++ ++ Sbjct: 174 SAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPDSIGLLPSASLSGIPDGNRKSNDIY 233 Query: 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFER 395 E H + + + S W +D + ++ V R Sbjct: 234 EPIH--VLPLVSRARASSTPSARSC-------PWPCFSDTL----STSLRRLWVPPWSLR 280 Query: 396 LMDGAKLLKCSEFGDAIIENM 416 + E G+A+I + Sbjct: 281 TKELGGGANTKELGEAVINEV 301 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats. Identities = 63/407 (15%), Positives = 127/407 (31%), Gaps = 79/407 (19%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + + G+G G ++T +V+ + + + IY S + Sbjct: 3 SIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADAVT 62 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRS-----LNVALRQELDLYICLRPVRYYQGTPSP 140 ETL YR K ++ V R+ +R++L ++ T SP Sbjct: 63 EETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQA------IKVEHFTLSP 116 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 +++ R+ ++ Y+G S DA Sbjct: 117 TSS-----ILLVRDQAQGFYSGTNSVNTSKDAVSR----------------------TAH 149 Query: 201 CSEEGTKRLVRAAIEYAIAN--DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 258 S+ R++ A+ A +SVT+V+K +G F W + Sbjct: 150 FSKAIFARILSYALGRANQLWGGTNSVTMVYK---FHLFDGLFHTWATE----------- 195 Query: 259 DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVG 318 V + + +D++A + ++++ N D + L + G Sbjct: 196 -WERTFGVNIRFVQGDTMNRDLLAFGV--------SGHNLLISGNEYADIMQTILLDRFG 246 Query: 319 GIGIAPGANIGDEC--------ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLR-HMGW 369 +G A + + ++ HG+A G+ VNP + I +A +L G Sbjct: 247 -LGAQESACAENVYLHPDVQGLSEYQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQAGC 305 Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + + + T D F +A ++ + Sbjct: 306 SGLKQRVDCVLGDLGARGIGTPDQ------GGTATTERFVEAFLQGL 346 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 145 bits (366), Expect = 2e-33, Method: Composition-based stats. Identities = 53/203 (26%), Positives = 91/203 (44%), Gaps = 33/203 (16%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG +++ +++K+ DAA + + + G + G+ +P Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAA-------KVPVEFETENAGSDVYEKTGE--LIPES 53 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 + + ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + Sbjct: 54 LYESVERNKIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNI 110 Query: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 D+ IFREN+E IY G E + I +K +++G++ Sbjct: 111 DLAIFRENTEGIYIGEEKYENEEKT---------------------SAIAVKRITKKGSE 149 Query: 208 RLVRAAIEYAIANDRDSVTLVHK 230 L++ + + + L K Sbjct: 150 ELLKVLLNMQRIMEFRKLQLFIK 172 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 143 bits (361), Expect = 9e-33, Method: Composition-based stats. Identities = 63/395 (15%), Positives = 115/395 (29%), Gaps = 47/395 (11%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I G G G ++ VV + + ++ S Sbjct: 5 DPLRIGVAIGHGTGPELATVFEHVVRELASR---YSLGVEFVRSDRIYHSYNSLPLADES 61 Query: 85 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSPV 141 T D+ E I R L V R + LY +R + + Sbjct: 62 QNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYA-VR--QQLEAVKVEC 118 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 201 + +++ R+ ++ Y G D+ + R+ + I F Sbjct: 119 FDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHFRKGVFQHIIAFSLERAREKWGY 178 Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 G SV LV+K +G W +EFG ++ Sbjct: 179 DLGGI----------------KSVFLVYK---FHLFDGLLLSWARD-WTKEFGIKVEFIQ 218 Query: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 P +N + +IA I+ I N + + + Sbjct: 219 PDTMNRN-LIAFGVHRCLMIAGNEYADIMQ------TIFLEKFNMRVQETSCSE---NVY 268 Query: 322 IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGME 381 + P N + ++ THG+A G+ VNP + I +A +L G I ++ Sbjct: 269 LKPVLN---RLSEYQTTHGSADDITGKGIVNPSATIRAAAAILERFG---GCVGIDAKVD 322 Query: 382 GAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +N + + D L + F D + + Sbjct: 323 DTLN--ILQKNKSGTPDQGGNLTTAAFVDVFLRTL 355 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 136 bits (343), Expect = 1e-30, Method: Composition-based stats. Identities = 65/404 (16%), Positives = 133/404 (32%), Gaps = 64/404 (15%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI-----SWMEIYTGEKSTQVYG 79 + + G G G ++ +V+ K Y + ++ +T S + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLA-KQYSVNFEFVRSSSTYHSYHTLTVSGEDKN 62 Query: 80 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 139 + ET +Y+ + + + R+ A LY+ +R ++ Q Sbjct: 63 LITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHA----QSLYL-VR--QHLQAAKV 115 Query: 140 PVKHPELTD-MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 198 + +++ R+ ++ YAG + + Sbjct: 116 EHFSLGDGNALLMVRDEAQGFYAGDNTYS----------------------ADQLSITRT 153 Query: 199 KPCSEEGTKRLVRAAIEYAIAN-----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 253 S+ R++R A++ A N VT+ +K +G F+ W Q + +F Sbjct: 154 TSFSKPVFDRIIRFALDRAAENWGPENVPKKVTMAYK---FHLFDGVFQAWEPQ-WKAQF 209 Query: 254 GGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDAL 313 G + P + + + +I +++P +N G S Sbjct: 210 GIDFDFIQPD-TLNRSLMANGVQGRCIIIAGNEYADVIQP------VFLNWFGQ--STPE 260 Query: 314 AAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEA 372 + + P N + ++ HG+A A + VNP + I +A +L RH G Sbjct: 261 TMYAENVYLRPDVN---GLSEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGI 317 Query: 373 ADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 L + ++ + K T D LK E D ++ + Sbjct: 318 QKLTEQAIQSLLQRKLTTPDQ------GGSLKTEETVDHFLQAI 355 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 135 bits (339), Expect = 4e-30, Method: Composition-based stats. Identities = 67/409 (16%), Positives = 119/409 (29%), Gaps = 78/409 (19%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 I G DG V A ++ + K I++ ++ ++ P Sbjct: 225 TVIAGYDG----VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANP---PERA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L P R L ++L Y PVR Sbjct: 278 L-------------WGVPDNTTGRK-LYKLVKQLKRYGI--PVRNAH------------- 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A + ++K + + + R + I + E Sbjct: 309 VSISRMSAGGGDQY---GSFNMPAQEDGILKVVVDGVEKHARRVSQGDPILLMSNDHEAI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V A ++ V K M++ + F + RE + Sbjct: 366 KDWVSQVFRDA-SSKHKEVYFGLKREYMEY-DEVFSTVINDVRRELAADHTSPPAFMIMR 423 Query: 267 KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGA 326 + L +++ P + NL+GD SD AA G + A Sbjct: 424 PSSQ---------------LIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSI 468 Query: 327 NIGDECAL-FEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHMGWTE------ 371 + FEA HGTA + NP ++I + L +G E Sbjct: 469 IESKSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALL 528 Query: 372 -AADLIVKGMEGAINAKTVTYDF---ERLMDGAKLLKCSEFGDAIIENM 416 + + ++ + VT D + L+ F D+I + + Sbjct: 529 DYSARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRL 577 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 120 bits (301), Expect = 1e-25, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 51/138 (36%), Gaps = 11/138 (7%) Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 + P+ + T++ P+ I + GDGIG +V V+ A + Sbjct: 20 SLSKPSSIRLATIRCSAATPPKRYSITLLPGDGIGPEVISVAKNVLKLAG---SLEGIEF 76 Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG------IRSLNVA 117 + E+ G + + G V LP ETL + ++ + G + + + Sbjct: 77 GFQEMPVGGCALDLTG--VPLPEETLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQ 134 Query: 118 LRQELDLYICLRPVRYYQ 135 LR L ++ LRP Sbjct: 135 LRSGLKVFANLRPASVLP 152 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 119 bits (297), Expect = 3e-25, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 79/225 (35%), Gaps = 30/225 (13%) Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251 E + S++G + +R A + A R VTL++K ++G+ + +L Sbjct: 13 EGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCH 72 Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311 ++ + + +++ P +D + ++S Sbjct: 73 YKDCLELELMEVEE-------------------AISRLMTEPTYFDCLFASERYATFLSA 113 Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + GG + IGD A+F+ T ++ I+ + + +H+G + Sbjct: 114 ICSGVCGGANLFSAVEIGDHHAVFKPLQ-TKLSLTNYANLSAYGIVSTIVDLFQHLGHDK 172 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 AD + ++ +N T + + G+ +I N+ Sbjct: 173 CADALWCELKRTMNEGIRTK------EFGG----QDTGEYVICNI 207 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 114 bits (285), Expect = 6e-24, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 8/122 (6%) Query: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEC---ALFEATHGTAPKYAGQDKVNPGSII 357 N+ GD +SD A G I +AP +I E +LFE HG+ P G+ NP + Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 358 L---SAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414 M+L H+G+ E I +E +++ D K + G AI Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPL--TPDLGGSAKTDDLGKAIAA 118 Query: 415 NM 416 + Sbjct: 119 AI 120 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 114 bits (284), Expect = 1e-23, Method: Composition-based stats. Identities = 62/412 (15%), Positives = 120/412 (29%), Gaps = 84/412 (20%) Query: 30 PYIEG-DGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 + G DG V A ++ + + + + + ++ ++ P Sbjct: 225 TVVPGYDG----VMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNP---PQRA 277 Query: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 L + + +K L Q+L Y G P + Sbjct: 278 LWGVPDNVSGMK--------------LYKLVQQLKHY----------GLP-----ERKAN 308 Query: 149 MVIFRENSED--IYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 206 + I R ++ Y A +IK + + + I E Sbjct: 309 VSISRMSAGGGDQYGSYNTPAPEDG---IIKVIMDGEEKHARTVKSNDPILFMSNDRESI 365 Query: 207 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKV 266 K V+ A + + + L RE + + L++ Sbjct: 366 KDWVKQVFRDAALYKK--------------------EVYFGLKREFVNYDEVYSSIILEI 405 Query: 267 KNPNTGKEIVIKDVIADAFLQQ---ILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIA 323 + + + +Q ++ P + + NL+GD SD AA G + A Sbjct: 406 RKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATA 465 Query: 324 PGANIGDECA-LFEATHGTAPKYAGQDK--------VNPGSIILSAEMMLRHM------- 367 + LFEA HGTA + N ++I + L + Sbjct: 466 SSVIKSKDGTLLFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNA 525 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERL---MDGAKLLKCSEFGDAIIENM 416 E A+ + + + T+T D + + ++ F DAI N+ Sbjct: 526 PLAEYAEALKAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESNL 577 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 76/210 (36%), Gaps = 23/210 (10%) Query: 112 RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169 RS N +R L+ + P + S K P + I R D Y + + Sbjct: 32 RSPNGTIRNILNGTVFREPILCKNVPRILSGWKKP----ICIGRHAFGDQYRATDTIING 87 Query: 170 ADAEKVIKFLR-EEMGVKKIRFPEHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTL 227 K++ E + + G+ + + + + R +++ A++ + + L Sbjct: 88 PGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLYL 146 Query: 228 VHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQ 287 K I+K +G FKD ++ E++ + + W + + D + Sbjct: 147 STKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIW-------------YEHRLIDDMVA 193 Query: 288 QILLRPAEYDVIACMNLNGDYISDALAAQV 317 + Y V AC N +GD SD LA Sbjct: 194 YAVKSEGGY-VWACKNYDGDVQSDFLAQIF 222 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 102 bits (255), Expect = 2e-20, Method: Composition-based stats. Identities = 29/139 (20%), Positives = 49/139 (35%), Gaps = 17/139 (12%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++ + ++ + + ++ ST Sbjct: 45 AKYGGRHTVTLIPGDGIGPELLNHVRELFR-------FSCVPVDFEVVHVNSSSTSEDDI 97 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTPV--GGGIRSLNVALRQELDLYICLRPVRYYQGTP 138 + IR VA+KG + T +S N LR LDLY + + G Sbjct: 98 S-----NAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQ 152 Query: 139 SPVKHPELTDMVIFRENSE 157 + + D++I E SE Sbjct: 153 T---RHKNIDIIIILEKSE 168 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 99.8 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 26/129 (20%) Query: 117 ALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVI 176 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 1 MLHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE--- 54 Query: 177 KFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 236 +K ++ + R+ A + A V VHK NI K Sbjct: 55 --------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKL 94 Query: 237 TEGAFKDWG 245 +G F Sbjct: 95 GDGPFLQCC 103 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 88.6 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 51/148 (34%), Gaps = 12/148 (8%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + + GD IG ++ LK + VE+ + ++ + S + + + Sbjct: 6 KLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRY--GLLAGASLDKTNEP--ITDK 61 Query: 88 TLDLIREYRVAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTPSPV 141 LD + G + P + LRQ LD + +RP R + + Sbjct: 62 VLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCR-FCASSLVE 120 Query: 142 KHPELTDMVIFRENSEDIYAGIEWKADS 169 + P +DMV N + YA Sbjct: 121 QSPLKSDMVNG-VNFGEQYAARSRSTGG 147 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 88.6 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 44/322 (13%), Positives = 98/322 (30%), Gaps = 71/322 (22%) Query: 27 PIIPYIEGDGIGVD---VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVW 83 + ++GD + V L ++ + + E+ G + + Sbjct: 2 YKLAILKGD---KESSSVIDRALGIIKS----SVNDSTAFEVTELPFGVNGVLSFNEP-- 52 Query: 84 LPAETLDLIREYRVAIKGP----LTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP- 138 LP +TL ++ Y + G + T ++ VALR+ L++ + + Q + Sbjct: 53 LPNQTLRELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLA---CKAVQISDN 109 Query: 139 ----SPVKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 192 SP+K+ TD +I R V + Sbjct: 110 NVDASPLKNQIVRDTDFIIV-----------------------QSAKRANDHVDGNISVD 146 Query: 193 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 252 + ++++ A E A+ R VT+V + +T + ++A+ Sbjct: 147 DFAQDTITYEQREVEQVITAGFERAMNRKRA-VTVVTPFDSF-YTSKIWALTAEKIAK-- 202 Query: 253 FGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDA 312 ++V+ V + I+ +P DV+ +++ Sbjct: 203 ------------------IYPDVVVNYVSLSCVISTIIQQPTSLDVVVAPKWVDQVLNEE 244 Query: 313 LAAQVGGIGIAPGANIGDECAL 334 G P + + + Sbjct: 245 SQKITGLPETVPVSMKNNSGQM 266 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 87.8 bits (216), Expect = 8e-16, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 41/79 (51%), Gaps = 5/79 (6%) Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLM 397 HG+APKYAG KVNP +++LS MML+ + EAA I KG++ + Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKH-----LTY 58 Query: 398 DGAKLLKCSEFGDAIIENM 416 D E+ DAII+ M Sbjct: 59 DAGGTASTDEYADAIIKAM 77 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 87.0 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 59/409 (14%), Positives = 118/409 (28%), Gaps = 81/409 (19%) Query: 27 PIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ---DVW 83 P + G G G +V +V+ + + + +Y S + Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAG 90 Query: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD---LYICLRPVRYYQGTPSP 140 +P + + A V R ++ LY+ +R + + Sbjct: 91 VPE--IRRLSAEDAA--HYEEWLRARARAGTRVVFRTAINAQSLYL-VR--QRLRAVKVD 143 Query: 141 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 200 + +++ R+ ++ Y G + Sbjct: 144 TLDADGARLLLVRDEAQGFYTGGNTHTPGHVSR------------------------TTE 179 Query: 201 CSEEGTKRLVRAAIEYAIA---NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 257 S E T++L+ A+ A + + +K +GA W A E Sbjct: 180 FSREITEQLLAYALRRAREEWPEGPARIVMAYK---FHLLDGALDAWVRDFAARENIEVG 236 Query: 258 IDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLR-PAEYDVIACMNLNGDYISDALAAQ 316 + D + ++ P + V+ N D + L + Sbjct: 237 VFQP---------------------DTVNRNLVAHPPEDRTVLLAGNEWADIMHLVLLDR 275 Query: 317 VGGIGIAP---GANIGDECAL-----FEATHGTAPKYAGQDKVNPGSIILSAEMML-RHM 367 G G N+ + A+ ++ HG+A G+D +NP + + +A + R++ Sbjct: 276 YGS-GRQEDHCTRNVHLDPAVAELVEYQTVHGSADDLEGRDLLNPVATLRAAAAIAERYV 334 Query: 368 GWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 G T A + A T D + DA IE + Sbjct: 335 GCTGAEAATEAALARLAAAGVRTPDQ------GGKHSTTGVVDAFIEEL 377 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 85.9 bits (211), Expect = 3e-15, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 39/117 (33%), Gaps = 15/117 (12%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 I I GDGIG ++ KV+D K + I G S G V L E Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTK---YGHSFLYEAILMGGCSIDATG--VPLTDE 58 Query: 88 TLDLIREYRVAIKGPLTTPVGGGIRS----------LNVALRQELDLYICLRPVRYY 134 + + + G + + LR+ L+L+ LRP Y Sbjct: 59 AIAAAKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 81.6 bits (200), Expect = 5e-14, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 5/103 (4%) Query: 16 LQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKST 75 ++ + I + GDG+G +V P + V+ A S+ E+ G + Sbjct: 30 IRCAANTPKKRYTIAVLPGDGVGNEVIPVAVDVLCLAG---SLEGIDFSFEELPIGGVAL 86 Query: 76 QVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVAL 118 + G V LP ETL ++ + G + I +++ Sbjct: 87 DLVG--VPLPKETLIRAKQSDALLLGAVGWYGIITITFVHLKF 127 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 81.6 bits (200), Expect = 5e-14, Method: Composition-based stats. Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Query: 335 FEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDF 393 +E G+AP AG++ NP + ILS M++R+ M +D I + + T D Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 394 ERLMDGAKLLKCSEFGDAI 412 D K ++ GD I Sbjct: 71 AN--DKEKCESTNDIGDII 87 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 78.2 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 30/72 (41%) Query: 345 YAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLK 404 + NP ++ +A ML ++G A LI + T D + + + Sbjct: 2 ICRXNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVG 61 Query: 405 CSEFGDAIIENM 416 EF +A+I+N+ Sbjct: 62 TKEFAEAVIDNL 73 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 78.2 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 + I I GD IG +V ++ V+ + E ++ + E+ G + G+ ++ Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQE--ILSTYRLEFTELDWGTARYKRTGK--YM 62 Query: 85 PAETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQEL 122 PA+ L ++ + I G + P IR L+ +R+ Sbjct: 63 PADGLSTLKTFHAGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 77.0 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 46/136 (33%), Gaps = 6/136 (4%) Query: 283 DAFLQQILLRPAEYDV--IACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHG 340 DA + + + + + A+ + A ++ + HG Sbjct: 153 DANVLSFIKHSQYSKANQVVSSMEGANVLKALYASIYKSLNRAHTLIEVEDGYITMPMHG 212 Query: 341 TAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 AP G NP +++++ +L G+ E A + +E A + D Sbjct: 213 HAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVENQIESAFYENR----DQTTPDQG 268 Query: 401 KLLKCSEFGDAIIENM 416 +L ++ ++E + Sbjct: 269 GVLNTEKYMAMMVECI 284 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 75.5 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%) Query: 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWTEAADLIVKGMEGAINAKTVTYDFERLMD 398 G+AP AG++ NP + ILS M++R+ M + AD I + A+ T D + + Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVNE 61 Query: 399 GAKLLKCSEFGDAIIENM 416 + S+ GD I + Sbjct: 62 --THISTSDMGDVISNIL 77 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409 NP ++++ A MLRH+ ++ I + + A V R D EF Sbjct: 155 IANPTAMLMCASKMLRHVNLQHYSESIRNAIREVLAAGKV-----RTRDLGGSSSTHEFT 209 Query: 410 DAIIENM 416 DA+I+ + Sbjct: 210 DAVIKAI 216 Score = 72.0 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 41/106 (38%), Gaps = 14/106 (13%) Query: 25 ENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWL 84 E I GDG+ ++ ++ V+ A S ++ + K Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAIGAPIDFETILFSEVQHSSSAKV---------- 112 Query: 85 PAETLDLIREYRVAIKGPLTTP---VGGGIRSLNVALRQELDLYIC 127 + + I R+ + G L +P G +++L++ LR+ LDL Sbjct: 113 -EDVIKSINRNRICLMGALMSPDVSYSGELQNLHMKLRKGLDLIAN 157 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 37/107 (34%), Gaps = 13/107 (12%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 I + GDGIG+++T +KV+ A K +R S G + Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSAFSLK----KRTFDLRSELIDGCSIDTDGTP--IT 415 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIR-------SLNVALRQELDLY 125 + + + + P G+R + LR+ ++ + Sbjct: 416 KTVIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 74.7 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 59/344 (17%), Positives = 120/344 (34%), Gaps = 63/344 (18%) Query: 39 VD--VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 96 + V PA L+++++A +W ++ G R+ Sbjct: 18 PEASVLPAALELLESA-------GLTANWR--IVAGQAPDGDGG------------RKPE 56 Query: 97 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 156 + P P G L A R+ + + V+ ++++FR Sbjct: 57 AGLLPPFAEP-GASAYGLARAARRAWGGTFSV-----IERRGPLVRSDGTVNVLLFRYEL 110 Query: 157 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 216 + G+E++++S + ++K E + PE +GI+ + + VR A+ Sbjct: 111 DMSDTGMEFESNSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGM 167 Query: 217 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIV 276 D D + + HKGN +K T+G F + +++ I Sbjct: 168 CRRLDVDDLVVAHKGNSIKHTDGLFALTAAE-----------------TLESLAGAAGIA 210 Query: 277 IKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG--IGIAPGANIGDECAL 334 + +I D +++ P +Y I + D ++ ALA Q+ +G+ + L Sbjct: 211 WRSLIIDHMAAELVRNPLDYRAILTHSSFADLLAAALAGQMTTDQLGVCTTYDPAGRP-L 269 Query: 335 FEATHGTAPKYAGQDKVNP--------GSIILSAEMMLRHMGWT 370 F H A + D +P S + + + H+ Sbjct: 270 F--GHDPALDTSAPD-ADPERWRVRRLASTLAAGAALAEHLRLP 310 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 71.6 bits (174), Expect = 5e-11, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 9/81 (11%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ ++ K+ +AA I W + + +P++ Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA-------NAPIEWDPVDV--TPVKGDDGIFRIPSK 77 Query: 88 TLDLIREYRVAIKGPLTTPVG 108 ++L+R ++ +KGPL TP Sbjct: 78 CIELMRINKIGLKGPLATPNW 98 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 67.0 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 33/86 (38%), Gaps = 11/86 (12%) Query: 21 LNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80 + I GDGIG ++T ++ ++ + I W + S Sbjct: 3 TKYGGVYTVTLIPGDGIGNEITDSVKEIFEYV-------NAPIEWEQYNVSGMS----SA 51 Query: 81 DVWLPAETLDLIREYRVAIKGPLTTP 106 L + ++ +R RV +KG L TP Sbjct: 52 GEDLFKQAVESLRRNRVGLKGILFTP 77 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 65.1 bits (157), Expect = 5e-09, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 33/86 (38%), Gaps = 4/86 (4%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP 85 + I I GDGIG + P L+V DAA + + + + +G+ P Sbjct: 3 SYRIAVIPGDGIGKEAVPERLRVPDAAARR-FGFALHCGHFDF-ASSDTRARHGK--LRP 58 Query: 86 AETLDLIREYRVAIKGPLTTPVGGGI 111 + D +R Y G + P G Sbjct: 59 DDRFDTLRGYDALFFGAVGRPDTGAA 84 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 64.3 bits (155), Expect = 9e-09, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 46/143 (32%), Gaps = 28/143 (19%) Query: 86 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 145 E + R A+ + + + + +LDLY+ R + G Sbjct: 104 DEYFHSVLRNRTAV--HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKCRF---P 158 Query: 146 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 205 D+ + +N+ I+ +E+ E + S++G Sbjct: 159 GVDIQLIGQNNMGIFNELEYSPVEGVVE-----------------------ALSVVSQKG 195 Query: 206 TKRLVRAAIEYAIANDRDSVTLV 228 + +R A + A R VTL+ Sbjct: 196 NDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 63.5 bits (153), Expect = 1e-08, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 334 LFEATHGTAPKYAGQDKVNPGSIILSAEMML-RHMGWTEAADL 375 +FE HG+AP AG++ NP + I S ML RH G A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 62.8 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 33/152 (21%), Positives = 58/152 (38%), Gaps = 29/152 (19%) Query: 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286 + HKGN +K+T+G F +A++E + D G I+ + +I D Sbjct: 1 MTHKGNSIKYTDGLFAV----VAKQELEKLIGDSG-------------IIQESLIIDHMA 43 Query: 287 QQILLRPAEYDVIACMN---------LNGDYISDALAAQVGGIGIAPGANIGDECALFEA 337 ++ P +Y I L+G +D IG A G + AL A Sbjct: 44 AELTRNPQDYRAILTHGAFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDPA 102 Query: 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369 H AP+ ++ +L+ ++ H+ Sbjct: 103 RHTRAPEAEAAGRLRSV--LLAGSLLADHLDQ 132 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.2 bits (147), Expect = 6e-08, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 34/105 (32%), Gaps = 29/105 (27%) Query: 312 ALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTE 371 + +G+ +GD LF + ++ NP + +L++ MML H+ Sbjct: 25 VGPELMAAVGVIECLKLGD--GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHL---- 78 Query: 372 AADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 + D C +F +A+I + Sbjct: 79 -----------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 58.9 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 5/72 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87 + I GDGIG +++ A++K+ DAA R +E G K ++Y V L E Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIE---GYKFNEMYLDTVCLNIE 62 Query: 88 T--LDLIREYRV 97 T I+ Sbjct: 63 TACFATIKCSDF 74 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 58.5 bits (140), Expect = 4e-07, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 23/54 (42%), Gaps = 3/54 (5%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 79 + I + GDGIG ++ +KV++ A EK + G + +G Sbjct: 9 SKQILILPGDGIGPEIMTEAVKVLELANEK---YQLGFELTHDVIGGAAIDKHG 59 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 57.8 bits (138), Expect = 7e-07, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 32/89 (35%), Gaps = 6/89 (6%) Query: 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAK 387 +G LFE + ++KVNP +I S ++L G E A I + A Sbjct: 1 MGIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFGLQEEAGAIQMAVNSAGERG 58 Query: 388 TVTYDFERLMDGAKLLKCSEFGDAIIENM 416 T D C + GD + + Sbjct: 59 MYTTLDTLPKDI----NCDQLGDYLAAAI 83 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 55.5 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 27/61 (44%), Gaps = 5/61 (8%) Query: 356 IILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIEN 415 ++L++ +ML H+ + A++I + +N + +D SE +I+ Sbjct: 1 MLLASCLMLDHLKLHDYANMIRSAILTTMNETRL-----HTVDIGGQGTTSEVVQSIMRI 55 Query: 416 M 416 + Sbjct: 56 I 56 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 55.1 bits (131), Expect = 5e-06, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 25/52 (48%) Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 +MGW EA LI +E A + T D R M + L EFG+ I+ + Sbjct: 1 EYMGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYIMSVL 52 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.2 bits (121), Expect = 6e-05, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%) Query: 220 NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEI 275 + VT +HK NIMK +G F +LA++ E + P+ I Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLERRGSESGIDTDKPDVCFNI 130 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 50.4 bits (119), Expect = 1e-04, Method: Composition-based stats. Identities = 21/138 (15%), Positives = 43/138 (31%), Gaps = 23/138 (16%) Query: 5 VVVPAQGKKITLQNGKLNVPENPII--PYIEGDGIGVDVTPAMLKVV-DAAVEKAYKGER 61 + + + +N + + P +E DG M +++ + EK Sbjct: 25 LAPATTCQSLQQRNYGD---KRIKVSQPVVEMDG------DEMTRIIWEFIKEKLILSNV 75 Query: 62 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI---------R 112 + G V + ++ ++Y VA+K TP + + Sbjct: 76 DVELKYYDLGLPYRDQTDDQVTI--DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWK 133 Query: 113 SLNVALRQELDLYICLRP 130 S N +R L + P Sbjct: 134 SPNGTIRNILGGTVFREP 151 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 48.5 bits (114), Expect = 5e-04, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 18/28 (64%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEK 55 I + GDGIG ++ A L+V++A EK Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 48.1 bits (113), Expect = 6e-04, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 7/71 (9%) Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70 G I++ + GDGIG ++ ++ +V AA + I W E + Sbjct: 28 GPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAA-------DVVIDWDEQFV 80 Query: 71 GEKSTQVYGQD 81 G + Sbjct: 81 GTEVDPRTNSS 91 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 47.7 bits (112), Expect = 7e-04, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 29/84 (34%), Gaps = 14/84 (16%) Query: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 ++E A++ A + + L K I+K +G FKD ++ + + + G Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 262 PWLKVKNPNTGKEIVIKDVIADAF 285 W + + D Sbjct: 60 IW-------------YEHRLIDDM 70 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 47.4 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 18/50 (36%), Gaps = 3/50 (6%) Query: 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV 77 I + GDGIG ++ L+V++A EK G Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEK---TGFDYEIDRRPFGGADIDA 50 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 47.4 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 11/32 (34%) Query: 20 KLNVPENPIIPYIEGDGIGVDVTPAMLKVVDA 51 + I GDGIG ++ + V Sbjct: 106 SAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 47.0 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 17/51 (33%), Gaps = 5/51 (9%) Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 H+G E A+ I +E +N D R EF A + Sbjct: 39 HVGEGEKANAIRNAVEKVLN-----IDNVRTGGLGGSATTKEFTAATERRL 84 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 46.2 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 26/78 (33%), Gaps = 13/78 (16%) Query: 352 NPGSIILSAEMMLRHMGWTE-------AADLIVKGMEGAINAKTVTYDFERLMDGAKLL- 403 NP + I + L T+ A+ + + I A +T D + G Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 404 -----KCSEFGDAIIENM 416 EF + + EN+ Sbjct: 66 CSDYLNTFEFMEKLGENL 83 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 44.3 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 24/82 (29%), Gaps = 13/82 (15%) Query: 348 QDKVNPGSIILSAEMMLRHMG-------WTEAADLIVKGMEGAINAKTVTYDFERLMDGA 400 + NP + I + L A + + ++ A ++ D + G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 401 KLLK-----CSE-FGDAIIENM 416 + SE D E + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERL 84 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 42.4 bits (98), Expect = 0.034, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 17/47 (36%), Gaps = 4/47 (8%) Query: 26 NPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE 72 I + GDGIG ++ ++V+D K + G Sbjct: 2 TKHIAILRGDGIGSEIVAETVRVLD----KLIAQGLDAGYEYAPLGG 44 >UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyaloperonospora parasitica RepID=Q6UB50_9STRA Length = 55 Score = 42.0 bits (97), Expect = 0.040, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 18/50 (36%), Gaps = 2/50 (4%) Query: 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 A LI K +E + T D D + ++ G AII M Sbjct: 3 FQMETEAQLIEKAVEQVLLDGMRTGDL--TKDKSAVVGTKTMGAAIIAKM 50 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.311 0.134 0.358 Lambda K H 0.267 0.0413 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,363,993,457 Number of Sequences: 3077464 Number of extensions: 95903922 Number of successful extensions: 257136 Number of sequences better than 1.0e-01: 236 Number of HSP's better than 0.1 without gapping: 578 Number of HSP's successfully gapped in prelim test: 66 Number of HSP's that attempted gapping in prelim test: 253624 Number of HSP's gapped (non-prelim): 753 length of query: 416 length of database: 1,040,396,356 effective HSP length: 131 effective length of query: 285 effective length of database: 637,248,572 effective search space: 181615843020 effective search space used: 181615843020 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 94 (40.8 bits)