BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (337 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bac... 475 e-132 UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Prot... 387 e-106 UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteri... 379 e-103 UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bact... 343 7e-93 UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseud... 331 2e-89 UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacte... 325 2e-87 UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocar... 320 5e-86 UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfi... 283 5e-75 UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodoco... 276 5e-73 UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta pr... 252 2e-65 UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellul... 236 7e-61 UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkho... 232 2e-59 UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salin... 230 5e-59 UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea Rep... 176 1e-42 UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseob... 169 1e-40 UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio ... 161 3e-38 UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ... 157 5e-37 UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimon... 148 2e-34 UniRef50_D1UDJ3 Acetaldehyde dehydrogenase (Acetylating), 4-hydr... 148 3e-34 UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octade... 139 2e-31 UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=M... 138 3e-31 UniRef50_C9Z9I1 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Ta... 125 2e-27 UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax... 122 2e-26 UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=... 116 1e-24 UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Ta... 109 1e-22 UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legione... 100 9e-20 UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 96 1e-18 UniRef50_C1BE00 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Ta... 96 2e-18 UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legione... 96 2e-18 UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q... 93 1e-17 UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 92 3e-17 UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 90 1e-16 UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria Re... 88 4e-16 UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geob... 86 2e-15 UniRef50_A2U042 HMGL-like protein n=1 Tax=Polaribacter sp. MED15... 86 3e-15 UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=... 85 3e-15 UniRef50_UPI0001AECE16 pyruvate carboxyltransferase n=1 Tax=Stre... 84 6e-15 UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacter... 81 5e-14 UniRef50_Q4HR83 4-hydroxy-2-ketovalerate aldolase, putative n=2 ... 80 7e-14 UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C... 80 7e-14 UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostri... 79 3e-13 UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenom... 79 3e-13 UniRef50_B1T1D8 Pyruvate carboxyltransferase n=1 Tax=Burkholderi... 75 3e-12 UniRef50_C5CLY8 Pyruvate carboxyltransferase n=1 Tax=Variovorax ... 73 1e-11 UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacte... 71 5e-11 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 71 7e-11 UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostri... 70 9e-11 UniRef50_D0LRX4 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 70 1e-10 UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter l... 70 1e-10 UniRef50_C4Z863 HMGL family protein n=4 Tax=Bacteria RepID=C4Z86... 70 1e-10 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 69 2e-10 UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria Re... 69 2e-10 UniRef50_C4Z4L3 Putative uncharacterized protein n=1 Tax=Eubacte... 69 2e-10 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 69 2e-10 UniRef50_Q12KS9 Pyruvate carboxyltransferase n=2 Tax=Gammaproteo... 69 2e-10 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 69 3e-10 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 69 3e-10 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 68 5e-10 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 67 6e-10 UniRef50_B3QVI9 Pyruvate carboxyltransferase n=5 Tax=Bacteroidet... 67 1e-09 UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma pr... 67 1e-09 UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synech... 66 1e-09 UniRef50_Q1IEM5 Putative uncharacterized protein n=1 Tax=Pseudom... 65 3e-09 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 65 3e-09 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 65 5e-09 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 64 5e-09 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 64 7e-09 UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 T... 64 1e-08 UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular ... 64 1e-08 UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase ... 63 1e-08 UniRef50_Q24S97 Putative uncharacterized protein n=1 Tax=Desulfi... 63 1e-08 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 62 2e-08 UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryante... 62 3e-08 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 62 3e-08 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 62 3e-08 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 62 4e-08 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 62 4e-08 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 61 5e-08 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 61 5e-08 UniRef50_D0FNJ3 Conserved uncharacterized protein n=2 Tax=Erwini... 61 6e-08 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 61 7e-08 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 61 7e-08 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 61 7e-08 UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 61 7e-08 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 60 8e-08 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 60 8e-08 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 60 8e-08 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 60 1e-07 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 60 1e-07 UniRef50_Q0FWC0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 59 2e-07 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 59 2e-07 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 59 2e-07 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 59 3e-07 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 59 3e-07 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 59 3e-07 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 59 4e-07 UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides... 58 4e-07 UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteri... 58 4e-07 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 58 5e-07 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 58 5e-07 UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphapro... 57 7e-07 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 57 7e-07 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 57 7e-07 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 57 8e-07 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 57 8e-07 UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia... 57 9e-07 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 57 1e-06 UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga ma... 56 1e-06 UniRef50_Q21QR6 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Proteoba... 56 1e-06 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 56 2e-06 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 56 2e-06 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 56 2e-06 UniRef50_Q120B4 Hydroxymethylglutaryl-CoA lyase n=7 Tax=Bacteria... 56 2e-06 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 55 2e-06 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 55 3e-06 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 55 3e-06 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 55 3e-06 UniRef50_A7VV06 Putative uncharacterized protein n=1 Tax=Clostri... 55 3e-06 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 55 3e-06 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 55 3e-06 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 55 4e-06 UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyr... 55 4e-06 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 55 4e-06 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 55 4e-06 UniRef50_Q0QFQ4 Putative uncharacterized protein hbzL n=1 Tax=Ps... 55 4e-06 UniRef50_A9IXU0 Putative uncharacterized protein n=1 Tax=Bartone... 55 5e-06 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 55 5e-06 UniRef50_Q0RGT1 Putative aldolase n=1 Tax=Frankia alni ACN14a Re... 54 6e-06 UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Ta... 54 6e-06 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 54 6e-06 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 54 7e-06 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 54 8e-06 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 54 9e-06 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 54 1e-05 UniRef50_D1VPY0 Putative uncharacterized protein n=1 Tax=Frankia... 53 1e-05 UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferrop... 53 1e-05 UniRef50_D1PP40 Putative uncharacterized protein n=1 Tax=Subdoli... 53 1e-05 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 53 1e-05 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 53 2e-05 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 53 2e-05 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 53 2e-05 UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 53 2e-05 UniRef50_B0T0Z5 Pyruvate carboxyltransferase n=3 Tax=Bacteria Re... 52 2e-05 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 52 3e-05 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 52 3e-05 UniRef50_C5AMG4 MhpE-like protein n=1 Tax=Burkholderia glumae BG... 52 3e-05 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 52 3e-05 UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=St... 52 3e-05 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 52 4e-05 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 52 4e-05 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 52 4e-05 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 51 5e-05 UniRef50_C1YV80 Isopropylmalate/homocitrate/citramalate synthase... 51 6e-05 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 51 6e-05 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 51 6e-05 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 51 7e-05 UniRef50_Q2S361 3-hydroxy-3-methylglutaryl-CoA lyase n=1 Tax=Sal... 51 7e-05 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 51 7e-05 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 51 7e-05 UniRef50_C0FY13 Putative uncharacterized protein n=1 Tax=Rosebur... 51 8e-05 UniRef50_C0WJX1 Possible pyruvate carboxylase n=1 Tax=Corynebact... 50 8e-05 UniRef50_A1WEM7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Verminep... 50 9e-05 UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria Re... 50 9e-05 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 50 1e-04 UniRef50_D1Y2H6 Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase)... 50 1e-04 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 50 1e-04 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 50 1e-04 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 50 1e-04 UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 50 1e-04 UniRef50_UPI0001B521AE 2-isopropylmalate synthase n=1 Tax=Strept... 50 2e-04 UniRef50_C5EHC6 Pyruvate carboxylase subunit B n=2 Tax=Clostridi... 50 2e-04 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 49 2e-04 UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curviba... 49 2e-04 UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular... 49 2e-04 UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus... 49 2e-04 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 49 2e-04 UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, s... 49 2e-04 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 49 2e-04 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 49 3e-04 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 49 3e-04 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 49 3e-04 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 49 3e-04 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 49 4e-04 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 49 4e-04 UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax... 49 4e-04 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 48 4e-04 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 48 4e-04 UniRef50_D2SNE9 HMG-CoA lyase-like protein n=1 Tax=Streptomyces ... 48 4e-04 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 48 4e-04 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 48 4e-04 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 48 5e-04 UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier ... 48 5e-04 UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermu... 48 5e-04 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 48 6e-04 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 48 6e-04 UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular... 47 7e-04 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 47 9e-04 UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece ... 47 0.001 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 47 0.001 UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 47 0.001 UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 47 0.001 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 47 0.001 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 47 0.001 UniRef50_B9K1B8 Alpha-amylase-related protein n=13 Tax=Rhizobium... 47 0.001 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 47 0.001 UniRef50_Q46TI7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Ralstoni... 47 0.001 UniRef50_UPI0001C30DEA pyruvate carboxyltransferase n=1 Tax=Cone... 47 0.001 UniRef50_A6LCK8 Carboxylase, putative n=7 Tax=Bacteroidales RepI... 47 0.001 UniRef50_C5BFR7 3-hydroxy-3-methylglutaryl-CoA lyase n=4 Tax=Bac... 46 0.001 UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus ... 46 0.002 UniRef50_C3WDK2 Pyruvate carboxyltransferase n=6 Tax=Bacteria Re... 46 0.002 UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 46 0.002 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 46 0.002 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 46 0.002 UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase ... 46 0.002 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 46 0.002 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 46 0.002 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 46 0.002 UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 46 0.002 UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=... 45 0.003 UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Po... 45 0.004 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 45 0.004 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 45 0.004 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 45 0.004 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 45 0.005 UniRef50_A8RV44 Putative uncharacterized protein n=1 Tax=Clostri... 45 0.005 UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystinea... 45 0.005 UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase... 45 0.005 UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces ... 44 0.006 UniRef50_B1G528 Pyruvate carboxyltransferase n=2 Tax=Proteobacte... 44 0.006 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 44 0.006 UniRef50_B8IFJ3 Pyruvate carboxyltransferase n=3 Tax=Alphaproteo... 44 0.007 UniRef50_C4JI85 Pyruvate carboxylase n=1 Tax=Uncinocarpus reesii... 44 0.007 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 44 0.008 UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria Re... 44 0.008 UniRef50_B9LMV8 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 44 0.008 UniRef50_Q3IQK7 Homolog to 2-isopropylmalate synthase, homocitra... 44 0.009 UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copr... 44 0.009 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 44 0.009 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 44 0.009 UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkhold... 44 0.010 UniRef50_B2V325 Pyruvate carboxylase n=9 Tax=Clostridiales RepID... 44 0.010 UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatr... 44 0.011 UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geother... 44 0.012 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 44 0.012 UniRef50_Q2F685 Hydroxymethylglutaryl-CoA lyase isoform 1 n=2 Ta... 43 0.012 UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 43 0.013 UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus s... 43 0.014 UniRef50_Q8ELJ7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Oceanoba... 43 0.014 UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera ... 43 0.014 >UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bacteria RepID=HOA1_FRASN Length = 377 Score = 475 bits (1222), Expect = e-132, Method: Compositional matrix adjust. Identities = 228/328 (69%), Positives = 258/328 (78%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 LY+ DVTLRDGMHA+RH+YS+E R IA ALD + V +IEVAHGDGL GSS NYG GAH+ Sbjct: 27 LYVQDVTLRDGMHAVRHRYSVETARTIATALDASGVRAIEVAHGDGLAGSSINYGIGAHT 86 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D EWIEA V +A +LLLPGIGT+ DL+ A G R VRVATHCTEAD+SAQHI Sbjct: 87 DWEWIEAVTASVTNAIPTSLLLPGIGTVRDLRQAHALGIRSVRVATHCTEADISAQHISA 146 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 AR+LGMD GFLMMSHM P LA+QA+LME YGA C+YV DSGG + M D+RDRFRA Sbjct: 147 ARDLGMDVAGFLMMSHMAAPAELARQARLMESYGAHCVYVTDSGGRLTMDDVRDRFRAYS 206 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L P T+TG+HAHHNL LGVAN++ AVE G R+DASLAG GAGAGN PLE FIA AD Sbjct: 207 DVLDPATETGIHAHHNLGLGVANTVVAVENGATRVDASLAGQGAGAGNCPLEAFIAVADL 266 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 +GW+HG +L+ LMD ADD+VRPLQDRPVRVDRETL LGYAGVYSSFLRH E AA RYGL Sbjct: 267 MGWKHGCELFGLMDTADDVVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAAATRYGLD 326 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDL 333 IL E+G+R MVGGQEDMIVDVALDL Sbjct: 327 TRTILAEVGRRGMVGGQEDMIVDVALDL 354 >UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Proteobacteria RepID=HOA3_AZOSB Length = 346 Score = 387 bits (993), Expect = e-106, Method: Compositional matrix adjust. Identities = 193/337 (57%), Positives = 247/337 (73%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + G ++ + D+TLRDGMH RH +LE ++ IA+ LD A + IEV HGDGL GSS NYG Sbjct: 3 LRGTRITVHDMTLRDGMHPKRHLMTLEQMKTIAQGLDQAGIPLIEVTHGDGLGGSSVNYG 62 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F AH+D E++ A ++K AK++ LLLPGIGT+ LK A + G +RVATHCTEADVS Sbjct: 63 FPAHTDEEYLGAVIPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRVATHCTEADVSE 122 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 QHI+YAR+LGMDTVGFLMM+HM +PE L +QAKLME YGA CIYV DS G + ++ R Sbjct: 123 QHIRYARKLGMDTVGFLMMAHMNSPEGLVQQAKLMESYGANCIYVTDSAGHLLPDTVKAR 182 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 A++A LKPET+ G H HHNL++GVANSIAA+E G RIDA+ AG+GAGAGN P+EV I Sbjct: 183 IGAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVLI 242 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 A D +G + G D++ + D A+DLV P+ D P+R+DR+ L LGYAGVY SFL + A Sbjct: 243 AVCDLMGIETGVDVFKIQDVAEDLVVPIMDFPIRIDRDALTLGYAGVYGSFLLFAKRAEK 302 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 +YG+ A +ILVE+G+R MVGGQEDMI D A+ L K Sbjct: 303 KYGVPAREILVEMGRRGMVGGQEDMIEDTAITLAKAK 339 >UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteria RepID=HOA_GEOTN Length = 342 Score = 379 bits (972), Expect = e-103, Method: Compositional matrix adjust. Identities = 184/334 (55%), Positives = 243/334 (72%), Gaps = 2/334 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + ++I++V LRDG HAI HQY++E V +A+ALD+A V IEV+HGDGL GSS YG Sbjct: 5 RDIWITEVALRDGSHAINHQYTVEQVVSVAQALDEANVPYIEVSHGDGLAGSSLQYGLSR 64 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 ++E IEAA V K AKIA LLLPGIGTI +L A + G ++VR+ATH TEAD+SAQHI Sbjct: 65 TDEMELIEAAVSVCKKAKIAVLLLPGIGTIRELDAAAKRGVKMVRIATHVTEADISAQHI 124 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 A+ELG++ VGFLMMSHM + E L +QAKLME YGA +YVVDS GA+ ++ +R RA Sbjct: 125 TRAKELGLEAVGFLMMSHMASTEKLVEQAKLMESYGADVVYVVDSAGALLPHEVTERIRA 184 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 LK L E G H H+NLSL +AN++AA++EG RID S+ +GAGAGN EV +A Sbjct: 185 LKQSLGIE--IGFHGHNNLSLAMANTLAAIQEGATRIDGSVRCLGAGAGNTQTEVLVAVL 242 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 D++G + G DLY +MD A+++V P+ P + R++L LGYAGVYSSF H E AA R+G Sbjct: 243 DRIGLKTGVDLYKMMDLAEEIVAPILQVPQEITRDSLILGYAGVYSSFRLHAERAAKRFG 302 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + + DILVELGKR++VGGQEDMI+D+A ++ + K Sbjct: 303 VDSRDILVELGKRKVVGGQEDMIIDIAAEIASKK 336 >UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bacteria RepID=HOA1_MYCSJ Length = 363 Score = 343 bits (879), Expect = 7e-93, Method: Compositional matrix adjust. Identities = 168/329 (51%), Positives = 219/329 (66%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D +LRDG H RHQ++ + V I ALD A V IEV HGDGL GSSFNYGF + Sbjct: 15 MTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQ 74 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 E I+ AA+ K AKIA L+LPG+GT D+K A G + R+ATHCTEADVS QH AR Sbjct: 75 ELIKLAAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLAR 134 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 ELG++TVGFLMMSH PE LA+QA++M G C+YVVDS GA+ + +RDR AL AE Sbjct: 135 ELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAE 194 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLG 247 L + Q G H H NL LGVANS+ AV G +ID S GAGAGNAP+E I DK+G Sbjct: 195 LGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIG 254 Query: 248 WQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAV 307 + G D + + DAA+++V P +DR L +GY+GVYSSFL+H + RYG+ A Sbjct: 255 VKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVPAH 314 Query: 308 DILVELGKRRMVGGQEDMIVDVALDLRNN 336 +L G+R+++GGQED ++D+AL+++ Sbjct: 315 QLLHRAGQRKLIGGQEDQLIDIALEIKRE 343 >UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseudomonas pseudoalcaligenes RepID=HOA1_PSEPS Length = 347 Score = 331 bits (849), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 167/334 (50%), Positives = 218/334 (65%), Gaps = 1/334 (0%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + GK + + D++L MH + +LE + + LD R+ IE+ DGL G S NY Sbjct: 3 LQGKNVTLYDMSLLXFMHPNPYHITLEQMIAVPTVLDAPRIPLIEITLRDGLGGRSINYV 62 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F AH D E++ A +K AK++ LLLPGIGT+ L A G + VATHCTEADVS Sbjct: 63 FPAHIDEEYLRAVIPRLKQAKVSALLLPGIGTVDHLNMALDCGVSTILVATHCTEADVSE 122 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKL-MEGYGATCIYVVDSGGAMNMSDIRD 179 HI +R LG DTVGFLMM+HM A A+L ++ YGA CIY DS G M ++ + Sbjct: 123 HHIGMSRMLGADTVGFLMMAHMIRRGKSAGAARLDVKCYGANCIYCTDSAGYMLPDEVSE 182 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 + L+AEL P T+ G H HHN+ + +ANS+A G RID S+AG+GAGAGN PLEVF Sbjct: 183 KIGLLRAELNPATEIGFHGHHNMGMAIANSLAGHRGGASRIDGSVAGLGAGAGNTPLEVF 242 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 +A ++G + G DLY +MD A+DLV P+ D+P+RVDR+ L LGYAGVYSSFL + A Sbjct: 243 VAVCKRMGVETGIDLYKIMDVAEDLVVPMMDQPIRVDRDALTLGYAGVYSSFLLFAQRAE 302 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDL 333 +YG+ A DILVELG+R VGGQEDMI D+ALD+ Sbjct: 303 KKYGVPARDILVELGRRGTVGGQEDMIEDLALDM 336 >UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacteria RepID=HOA2_RHOOB Length = 347 Score = 325 bits (832), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 165/330 (50%), Positives = 220/330 (66%), Gaps = 2/330 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDGM ++ HQ++ +NV IA+ LD A V +IEVAHG GL SS YGF A Sbjct: 7 KKITIVDTTLRDGMSSVSHQFTPQNVADIARGLDRAGVGTIEVAHGIGLGASSIQYGFAA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D +++ AA D V++A IA L +PGI T+ +L+ A AG + VRVA HCTEAD Q + Sbjct: 67 ATDPDYVRAAVDAVENADIAALYVPGIATLAELQKAIDAGIKTVRVAVHCTEADCGQQPV 126 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 ++A+E G+ + FLMMSH PE LA+QA ++ YGA +YVVDS GAM DR A Sbjct: 127 EWAKEQGLTVMTFLMMSHKLDPEPLAEQAAKLDSYGADVVYVVDSAGAMVPRHAGDRVAA 186 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + + G HAH+NL +G+AN++ A E G ID SL G+GA AGNA EV AA Sbjct: 187 LRQAISAD--IGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTEVLAAAF 244 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 ++ GW G DL+ L+D A+ +V PL P VD L LGYAGVYS+F + AA ++G Sbjct: 245 ERAGWDTGVDLFPLIDTAEHIVAPLMKEPQIVDETALILGYAGVYSTFFHPTKRAAKKFG 304 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDL 333 + A DIL+ELG+R ++GGQEDMI+DVA +L Sbjct: 305 VPARDILMELGRRGVIGGQEDMIIDVASEL 334 >UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocardia farcinica RepID=HOA2_NOCFA Length = 346 Score = 320 bits (819), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 164/330 (49%), Positives = 218/330 (66%), Gaps = 2/330 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDGM ++ H+++ +V IA LD A V +IEVAHG GL SS YGF A Sbjct: 6 RTVTLVDTTLRDGMSSVSHRFTPNDVAAIAAGLDRAGVRTIEVAHGIGLGASSIQYGFAA 65 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D E++ AA D V HA IA L +PGI T+ +L+ A +AG R VRVA HCTEAD + Q + Sbjct: 66 ATDPEYVRAAVDAVDHADIAVLYVPGIATLAELRAAVEAGIRTVRVAVHCTEADCAQQPV 125 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 ++A++ G+ + FLMMSH PE LA+QA +E YGA +YVVDS GAM DR A Sbjct: 126 EWAKDHGLTVMTFLMMSHKLDPEPLAEQAVKLESYGADVVYVVDSAGAMVPRHAGDRVAA 185 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + E G HAH+NL +G+AN++ A E G ID SL G+GA AGNA EV AA Sbjct: 186 LRRAISAE--IGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTEVLAAAF 243 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 ++ GW G +L+ L+D A+ +V PL P VD L LGYAGVYS+F + AAA++G Sbjct: 244 ERAGWHTGVELFPLIDTAEQVVAPLMTEPQIVDETALVLGYAGVYSTFFHPTKRAAAKFG 303 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDL 333 + DIL+ELG+R ++GGQEDMIVDVA +L Sbjct: 304 VPTRDILLELGRRGVIGGQEDMIVDVASEL 333 >UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD Length = 333 Score = 283 bits (725), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 145/334 (43%), Positives = 206/334 (61%), Gaps = 2/334 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D+TLRDG HA HQ++ E + +A+ +D V +IE HG+GL GS+ YGF A Sbjct: 2 KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFGHGNGLGGSALQYGFAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D E++EA A VVK+A ++ ++LPG+GT H+L A + GA+ R+ T TE D++ QHI Sbjct: 62 ATDREYMEAVAPVVKNADLSIIILPGVGTRHELHLAKEFGAKYARMCTQITEVDIAEQHI 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A++LGM + L + + ++ + ++ E YGA IY++D GG +R A Sbjct: 122 KMAKQLGMIPIAVLPCAGIIPVKDTVRYTQMAESYGAEVIYLLDGGGYQLPEQTYERIAA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 +K + + G H H+NL L VANS AAVE G + ID L G GAGAGN P E+F A Sbjct: 182 MKKAV--DVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFGAGAGNCPTEIFAAVM 239 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 D++ G DLY MD A+ +RPL R + VD + + LGYAG YSSFL + A ARYG Sbjct: 240 DRMEIDCGIDLYKTMDIAEQYLRPLMPRAMEVDNDRIMLGYAGCYSSFLLFAQRAGARYG 299 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + DI+ E+G+R+ GQED+ +DVA L K Sbjct: 300 VDPRDIIKEIGRRQCTEGQEDICIDVAYALAQKK 333 >UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus jostii RHA1 RepID=Q8KZT0_RHOSR Length = 359 Score = 276 bits (707), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 161/332 (48%), Positives = 200/332 (60%), Gaps = 10/332 (3%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG HA HQ++ VR +ALD A V+ IEV HGDGL GS+FNYGF SDL Sbjct: 12 IVDTTLRDGSHAQSHQFTESQVRDTVRALDGAGVEVIEVTHGDGLGGSTFNYGFSRISDL 71 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 E ++ AAD + AKIA LL+PGIGT DL+ A GA VVR+ATHCTEADVS QH + AR Sbjct: 72 ELVQVAADTAEQAKIAVLLVPGIGTADDLRKAADRGAEVVRIATHCTEADVSLQHFEIAR 131 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 +LGM T GFLMM+H TTPE LA+QA+LM G YV DS GA+ M + +DRF AL E Sbjct: 132 DLGMQTCGFLMMAHRTTPEELARQARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALITE 191 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLG 247 + + G H H N+SLGVANS+ A E G ID SL +GAG+GN+P E+ A D++ Sbjct: 192 VGDDAWVGYHGHQNMSLGVANSVIAYEAGVRYIDGSLCALGAGSGNSPTELLAAIFDRMN 251 Query: 248 WQHGTDLYALMDAADDLVRPLQDRPVR-VDRETLALGYAGV----YSSFLRHC-ETAAAR 301 + A D R P V R+++ + V YSSFL H + Sbjct: 252 IRD----RARRDGDIGCSRDSWCGPTSTVGRKSIGMRSCRVGSAWYSSFLLHAGDRGRPV 307 Query: 302 YGLSAVDILVELGKRRMVGGQEDMIVDVALDL 333 + A + V VGGQEDMI+DVA+ L Sbjct: 308 WRSGARESCVAAANWGYVGGQEDMIIDVAIQL 339 >UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta proteobacterium KB13 RepID=B6BTH8_9PROT Length = 337 Score = 252 bits (643), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 132/336 (39%), Positives = 193/336 (57%), Gaps = 3/336 (0%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ ISD TLRDG HAI+H++S +++ K D AR+ +EV HG+G+ SS G Sbjct: 1 MESKKILISDPTLRDGSHAIKHKFSKDDISNYCKLADKARIPIVEVGHGNGIGASSLQLG 60 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTI-HDLKNAWQAGARVVRVATHCTEADVS 119 SD + + A +K +K+ ++PG TI D+ A G V R+ATHCTE+D+S Sbjct: 61 ESLLSDFDMLSTARKNLKKSKLGVHVIPGFATIDKDILPAVDVGVDVFRIATHCTESDLS 120 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 +HI + R+ ++ G LMM+HM E L QAK +E YGA + +DS G+ + I++ Sbjct: 121 ERHISFLRKKNLEVWGCLMMAHMVDTETLIDQAKKIENYGADGVIFMDSAGSFIPNQIKE 180 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R L +EL G H H+NL+L VANS+ A++ G +DA AG GAGAGN LEV Sbjct: 181 RVEGLVSELN--IMVGFHGHNNLNLAVANSLEAIQSGATLVDACSAGFGAGAGNTQLEVL 238 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 I K + D L+D A+ ++ V +++ GY GV+S FL A Sbjct: 239 IPVLLKQNFDTNIDFNGLLDLAEFVISKFGKSTSSVHIDSMISGYYGVFSGFLVPVRRVA 298 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 Y +S +DI ELG+R ++ GQED+I++VA +R+ Sbjct: 299 LEYKISPIDIFKELGRRNIIAGQEDLIIEVANSIRD 334 >UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG Length = 340 Score = 236 bits (603), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 132/330 (40%), Positives = 183/330 (55%), Gaps = 1/330 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG HA+ H+ L +R+ A+A D ARV +EV HG+GL SS G A Sbjct: 2 KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVGHGNGLGASSLQVGLAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D + + ++H+++ T +LPG GT DL+ A G V RV H TEA ++ H+ Sbjct: 62 ATDDAMLSTVREALRHSRLGTFMLPGWGTSDDLRRAISHGVDVFRVGVHATEASLAEHHL 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + R+ G + LMMSHM +P LA+QA GYGA + ++DS G D+ R A Sbjct: 122 GFLRDAGAEAHCVLMMSHMASPGELAEQAARAVGYGAQAVGIMDSAGHFLPPDVTARIGA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 + E H H+NL + VANS+AA E G ID G GAGAGN LEV + Sbjct: 182 I-VEAVGTVPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGAGNTQLEVLVPVL 240 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 ++ G+ G DLYAL+DAAD R L P ++ G AGV+S F A G Sbjct: 241 ERSGFATGIDLYALLDAADLAERELMPAPPVPASMSIVSGLAGVFSGFKHRVVELAGAAG 300 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDL 333 + ++ ELG+R+ + GQED+IVDV +L Sbjct: 301 VDPREVFFELGRRQAIAGQEDLIVDVVAEL 330 >UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkholderia RepID=HOA_BURP0 Length = 347 Score = 232 bits (591), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 131/332 (39%), Positives = 187/332 (56%), Gaps = 2/332 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ISD TLRDG HAIRHQ S + A+A D+A +D +EV HG+GL GSS G Sbjct: 2 ILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGNGLGGSSCLLGQTPIG 61 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D +E A ++ +++ +PG+G D+ A + G VVRVATHCTEA+VSA+ I+ Sbjct: 62 DRLMLETARAALRTSRLGVHFIPGLGKAADISLALEIGVDVVRVATHCTEANVSARFIEQ 121 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 R G G LMMSHM P+ L QAKLME YGA + ++DS G S +R + L Sbjct: 122 TRTAGRTAFGVLMMSHMAPPDTLLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLV 181 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L + G HAH+NL L VANS+ A+E G +DA + G GAGAGN LE +AA ++ Sbjct: 182 DGL--DIDVGFHAHNNLGLAVANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMER 239 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 G T +M A L + + +A G G++S ++ H + AA +G++ Sbjct: 240 EGHDTRTTFERVMTLARGTETFLNPKTPHIQPANIASGLYGLFSGYVPHIQKAAQEFGVN 299 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L +R++V GQED+I++ A L + Sbjct: 300 EFELYKRLAERKLVAGQEDIIIEEASRLARER 331 >UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salinispora arenicola CNS-205 RepID=HOA2_SALAI Length = 348 Score = 230 bits (587), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 133/326 (40%), Positives = 185/326 (56%), Gaps = 3/326 (0%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 KL I D TLRDG HA+ HQ ++ A+A ++A VD +EV HG+GL SS G A Sbjct: 4 KLQICDSTLRDGNHAVAHQLGRADISAYARAAEEAGVDVLEVGHGNGLGASSIQVGIAAV 63 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEADVSAQHI 123 SD E + AA ++++++ L +PG ++ DLK A G VRV HCTEADV+ Q I Sbjct: 64 SDAEMLRAAKAELRNSRLGVLSIPGFASVERDLKPALDCGVDEVRVGAHCTEADVTRQQI 123 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 R +G+ G L+MSHM + L +QA LM+ YGA + ++DS GA +R++ Sbjct: 124 TMLRSMGVRVKGLLLMSHMASAGKLVEQAGLMQEYGAEAVVLMDSAGAYTPEMVREKVGE 183 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L +L + G HAH+NL L V NSI AV G +D + G GAGAGNAP+E+ A Sbjct: 184 LVEKL--DIAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGAGNAPIELVAANL 241 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + L+ +DAAD D T+A G AGV+S F A+ R+G Sbjct: 242 HVEQIEARIKLFDALDAADTAEERFVKHVPTNDGVTIASGIAGVFSGFAAPVRRASRRFG 301 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDV 329 + +IL+ELG+RR+V GQED I++V Sbjct: 302 VDPREILLELGRRRVVAGQEDTIIEV 327 >UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS Length = 352 Score = 176 bits (445), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 97/331 (29%), Positives = 172/331 (51%), Gaps = 3/331 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG +++ ++ + I L+ + + IEV HG G S+ YG Sbjct: 3 KKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVGHGLGFNASNSGYGKST 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 SD E++ AA + + + +PGI + DL+ A + G +RV T T+ S + I Sbjct: 63 QSDEEYMIAAKESLSKSMYGMFCIPGIAKLSDLELAKKHGMGFIRVGTDVTKVHQSEKFI 122 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ LG M S++ P+ A K E +G +Y+VDS G M SD+ + + + Sbjct: 123 KKAKNLGFFVASNFMKSYVMPPDKFASIVKQSEEFGTDMVYIVDSAGGMFSSDLLEYYNS 182 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 ++ E G H H NL + ++NS+ A + G + ID+SL G+G +GNA EV + A Sbjct: 183 IRNV--SEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGIGRSSGNACTEVLVMAL 240 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 K G++ D ++L +A + V PL + ++ + ++ GYA +SS++ H ++++ Sbjct: 241 KKKGFKIDVDFHSLFEAGQECVYPLINNSNKLPLDIVS-GYADFHSSYMHHIMKYSSKFK 299 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 + + +++E K + E + +A L+ Sbjct: 300 VDPLLLIIEYSKINKIDIDEKKLEQIAKKLK 330 >UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseobacter sp. SK209-2-6 RepID=A4F0P9_9RHOB Length = 352 Score = 169 bits (429), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 106/329 (32%), Positives = 165/329 (50%), Gaps = 2/329 (0%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLRDG + I Q++ + I ALD A IEV HG G+ S A SD Sbjct: 9 VLDCTLRDGSYVIDFQFTSADTESIGGALDQAGFPYIEVGHGVGMGASETGNNVAAASDA 68 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 +++ AAA V K +PG+ + ++ A G +RV T +AD + I+ AR Sbjct: 69 DYMAAAAKSVTSGKWGMFCIPGVANLDHVRLAADHGIGFIRVGTDVAQADSAIPFIELAR 128 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 +LG++ M S++ PE A YGA +Y+VDS G M ++R +A K+ Sbjct: 129 KLGIEVFANFMKSYVLEPEAFGALAARSYDYGAEMVYLVDSAGGMLPHEVRAYLQAAKSA 188 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLG 247 PE G H H NL L VANS+ ++EEG +D SL G G +GN E+F+ A + G Sbjct: 189 -APELPLGFHGHDNLGLAVANSLVSLEEGAAMVDTSLQGFGRSSGNTATELFLGATIRSG 247 Query: 248 WQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAV 307 ++ + +MD + LVRPL +R + +A G A +SS++ A + + Sbjct: 248 YEAFAEPIEVMDLGETLVRPLIERRGFCSLD-IAAGQALFHSSYMPKILRVAKQNRVDPR 306 Query: 308 DILVELGKRRMVGGQEDMIVDVALDLRNN 336 +++EL K V ++++ +A +L N Sbjct: 307 RLIIELCKHDKVNAPDELLSRLAAELSEN 335 >UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR Length = 354 Score = 161 bits (407), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 100/326 (30%), Positives = 167/326 (51%), Gaps = 4/326 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I + TLRDG + I Q+S +N IA ALD+A + IEV HG GL + G Sbjct: 1 MNNPK--ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHGVGLGATEKKIG 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 SD ++++AA+ V + K +PGI T+ L+ A +R+ + + S Sbjct: 59 VALESDEVYMKSAAESVTNGKWGMFAIPGIATLEHLEMAKNYDMDFIRIGSTIEDFPKSE 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + A+ GM T M S+ PE+LA+ +KL G +YVVDS G M ++++ Sbjct: 119 AFVSSAKSQGMMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSAGGMLPNEVKLY 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 A+ AE K + G H H+NL LG+ N++AA+E G ID SL G G AGN E + Sbjct: 179 VEAILAE-KSDAVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGFGRSAGNTTTEQML 237 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 ++G + D +MD ++L++P+ ++ +T++ G A +SS++ + Sbjct: 238 GCLARMGLEGNIDPIKVMDIGEELIKPMIEKRGLTSIDTVS-GMALFHSSYMPVIHEMST 296 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMI 326 +Y + ++ + +V + +++ Sbjct: 297 KYRVDPRQLISAVCSEDIVNAESELV 322 >UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ferrooxidans DSM 13031 RepID=Q0YTT0_9CHLB Length = 681 Score = 157 bits (397), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 101/311 (32%), Positives = 159/311 (51%), Gaps = 5/311 (1%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG + I +Q++ + IA L+ + ++ IEV HG GL G A +DL Sbjct: 10 ILDTTLRDGSYTIGYQFTADETALIAHGLELSGINYIEVGHGLGLGADRAGKGAQAVTDL 69 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 ++ A ++ ++ A+ +PGIG + DLK G VRV D + I+ A+ Sbjct: 70 VYMRACSNAIRRARFGFFYIPGIGELSDLKLLADEGGAFVRVGVSLDAIDQACHAIREAK 129 Query: 128 ELGMDTVGFLMMSH-MTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 LG++ +M + + E+ + +E GA +YVVDS G M S++ + ++ Sbjct: 130 RLGLEVWANIMKIYAYSLKESREGSLRFVEA-GADGVYVVDSAGGMLPSEVAEYVSEIRK 188 Query: 187 ELK---PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 E + G H H NLSL A S++AV GCD +D SL G+G GNA EV Sbjct: 189 EFTLAGVSARIGFHGHDNLSLSTACSLSAVGAGCDIVDGSLLGIGRSIGNAATEVLAMVL 248 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + G++ G + + D A+ +RP ++ R ALG+A ++S FL E AA +Y Sbjct: 249 CRAGYETGVNAWNAGDLAEKTIRPFLEQRWRHSSLEQALGFAQIHSGFLPLLEKAALQYQ 308 Query: 304 LSAVDILVELG 314 +S D+++ LG Sbjct: 309 ISLRDVVLVLG 319 >UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0IC26_VIBHO Length = 355 Score = 148 bits (374), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 99/319 (31%), Positives = 160/319 (50%), Gaps = 2/319 (0%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I + TLRDG + I Q+S + I KALD A + IEV HG GL S N G +D Sbjct: 7 ILECTLRDGSYEIDFQFSKKQTSDICKALDTAGFELIEVGHGVGLGASEKNIGVALETDE 66 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 ++EAAA+ VK+ K +PGI H L A +R+ + + S++ I A+ Sbjct: 67 VYMEAAANNVKNGKWGMFAIPGIAEKHHLDIASDYDMDFIRIGSTIEDFPKSSEFIDKAK 126 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 L M T M S+ + PE LA + G +YVVDS G M +++++ A+KAE Sbjct: 127 SLSMMTCVNFMKSYTSKPEKLAIASSAAFEMGVDVVYVVDSAGGMLPNEVKNYVEAIKAE 186 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLG 247 G H H+NL LG+ N++AA+ G ID SL G G AGN E + ++G Sbjct: 187 -NTNAIVGFHGHNNLGLGIGNALAALNAGASIIDTSLQGFGRSAGNTTTEQMLGCLARMG 245 Query: 248 WQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAV 307 + D +MD ++L++PL ++ +T++ G + +SS++ + +Y + Sbjct: 246 IEGKIDPIVVMDIGEELIKPLIEKRGLTSLDTVS-GISLFHSSYMPTIHDMSVKYRVDPR 304 Query: 308 DILVELGKRRMVGGQEDMI 326 ++V + +V +++ Sbjct: 305 LLIVSVCSEDIVNANAELV 323 >UniRef50_D1UDJ3 Acetaldehyde dehydrogenase (Acetylating), 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Burkholderia sp. CCGE1001 RepID=D1UDJ3_9BURK Length = 281 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 72/99 (72%), Positives = 84/99 (84%), Gaps = 1/99 (1%) Query: 235 PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRH 294 P V I+ + G HG ++ L+DAADD+VRPLQ+RPVRVDRETLALGYAGVYSSFLRH Sbjct: 168 PARVRIST-KRQGLNHGCNVKQLIDAADDIVRPLQERPVRVDRETLALGYAGVYSSFLRH 226 Query: 295 CETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDL 333 E AAA+YGLSA DI+VELG+RRMVGGQEDMIVDVAL++ Sbjct: 227 TEAAAAKYGLSAFDIMVELGRRRMVGGQEDMIVDVALEM 265 >UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB Length = 830 Score = 139 bits (349), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 92/330 (27%), Positives = 156/330 (47%), Gaps = 12/330 (3%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG + ++L+ R + L ++ IEV HG GL + +D Sbjct: 3 ILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGHGIGLGATEKGISPAVETDQ 62 Query: 68 EWIEAAADVVKH-----AKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 ++++AAA V+ AK +PGI ++ + A +R+ + +++ Sbjct: 63 DYMKAAALAVEESGSQKAKWGMFCIPGIAELNHIDLAHDHNMGFIRIGVTVEDINLARSF 122 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 ++ +++LG+ M S+ ++P+ + +GA Y+VDS G M +D+ D FR Sbjct: 123 VEKSKKLGLYVCVNFMKSYTSSPQEFSAAVAQAASFGADIAYLVDSAGTMVPADVEDYFR 182 Query: 183 ALK-AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 ++ + P G H H+NL L N+ A EG +D S+ GMG GN E F+A Sbjct: 183 TVRRNSILP---LGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTEHFLA 239 Query: 242 AADKLGWQHGTDLYALMDAADDLVRP-LQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 K G H D LMD ++ VRP L D + +D +A G AG +SS++ + + Sbjct: 240 LLGKQGIAHNLDPIGLMDLSEKYVRPKLTD--IGIDSVDVACGLAGFHSSYMSVIKKYSL 297 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 Y + +++EL K E ++ + A Sbjct: 298 EYDIDPRRLIIELCKETRDAAPEKLVKEKA 327 >UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=Mycobacterium tuberculosis complex RepID=A5U8E4_MYCTA Length = 336 Score = 138 bits (348), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 93/314 (29%), Positives = 159/314 (50%), Gaps = 8/314 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + ++ A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGP-AA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIH--DLKNAWQAGARVVRVATHCTEADVSAQ 121 H+D E+ AA VV++A++ +++P + I DL + R+ +AT E ++ Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIAT---EFELVMP 123 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++ A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R Sbjct: 124 FVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYV 183 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 AL+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +A Sbjct: 184 EALRG--ASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVA 241 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAAR 301 A + G DL + DAA + + +D ++ G+ G+ S + H AA + Sbjct: 242 ALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQ 301 Query: 302 YGLSAVDILVELGK 315 GLS ++ + K Sbjct: 302 AGLSVSHVIRQTAK 315 >UniRef50_C9Z9I1 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Streptomyces scabiei 87.22 RepID=C9Z9I1_STRSW Length = 114 Score = 125 bits (315), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 57/89 (64%), Positives = 73/89 (82%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++Y+ DVTLRDGMHA+RH+ S +V +I ALD+A VD+IE+AHGDGL GSS NYG G+H Sbjct: 4 QIYVQDVTLRDGMHAVRHRISPVDVARIVTALDEAGVDAIEIAHGDGLAGSSVNYGPGSH 63 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTI 93 +D EWIE AA V+K A++ TLLLPG+GTI Sbjct: 64 TDWEWIETAASVLKRARLTTLLLPGVGTI 92 >UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Mycobacterium tuberculosis KZN 4207 RepID=UPI0001B44BFA Length = 483 Score = 122 bits (307), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 129/244 (52%), Gaps = 8/244 (3%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + ++ A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGP-AA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIH--DLKNAWQAGARVVRVATHCTEADVSAQ 121 H+D E+ AA VV++A++ +++P + I DL + R+ +AT E ++ Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIAT---EFELVMP 123 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++ A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R Sbjct: 124 FVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYV 183 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 AL+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +A Sbjct: 184 EALRG--ASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVA 241 Query: 242 AADK 245 A + Sbjct: 242 ALQR 245 Score = 96.7 bits (239), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 101/209 (48%), Gaps = 2/209 (0%) Query: 107 VRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +R+ TE ++ ++ A+ G++ L+ SH+ P+ LA K G +YVV Sbjct: 256 LRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVV 315 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G D R AL+ + G H H+NL++ VAN++ A + G D +D +L G Sbjct: 316 DTTGTFLPEDARRYVEALRG--ASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMG 373 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAG 286 G GAGN +E +AA + G DL + DAA + + +D ++ G+ G Sbjct: 374 FGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHG 433 Query: 287 VYSSFLRHCETAAARYGLSAVDILVELGK 315 + S + H AA + GLS ++ + K Sbjct: 434 LDSLQVEHLRAAAQQAGLSVSHVIRQTAK 462 >UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34E31 Length = 351 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 93/341 (27%), Positives = 158/341 (46%), Gaps = 14/341 (4%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N KK+ + D TLRDG + + +S E + L +V IE + G+ G+ GF Sbjct: 17 NKKKIQLMDCTLRDGANVVGKGFSAEITDMVLDGLTSCKVPIIEFGNAGGI-GAYEVAGF 75 Query: 62 -GAHSDLEWIEAAADVV-KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 A +D E++E A + + ++I L + A + G +RV + ++ Sbjct: 76 TNALTDSEYLEIAKKYLNRGSEIGMFLNAKRYREKYVDMAAENGLAFLRVGADAGDGSIA 135 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 Q I ++ GM M +++ T + LA++ K +E G I ++DS G M + + Sbjct: 136 LQAIADIKKRGMKAYYSAMKAYLLTADELAEEGKRLEEAGLDEITIMDSAGTMLPEQVAE 195 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R L + H H+NL L AN+IAA E G D +D L GM AGN P E+ Sbjct: 196 YTRKLSEAVS--IPVAFHCHNNLGLSAANAIAAFENGADILDCGLMGMARSAGNLPTEIC 253 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDR-----PVR-VDRETLALGYAGVYSSFLR 293 A +LG DLY ++ + + P ++ PV+ +D + LGY+G +SSF++ Sbjct: 254 AAMMRRLGQMEEIDLYGMLSFIKNRLEPAMEKHSYHNPVKPLD---VVLGYSGCHSSFVK 310 Query: 294 HCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 + A G+ ++ E+ + ++++ A LR Sbjct: 311 TFQAVAEEKGVDLFRLICEVSEIDKKSPSKELMEQTADKLR 351 >UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XTF5_DESMR Length = 345 Score = 109 bits (273), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 89/333 (26%), Positives = 151/333 (45%), Gaps = 13/333 (3%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + + + TLRDG + + E A+ L IEV HG GL G+ Y G Sbjct: 2 KNVTLLECTLRDGAYKVDFMIDQETCCAFAEKLVRIGFQDIEVGHGLGL-GAYRQYSAG- 59 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D + A + +++ + +P +G D + A G +RV S + Sbjct: 60 FTDEALYKRLAPLAARSRLYSFFIPSVGKPDDFRMARDYGLYGLRVGAEPVYVLDSIPTL 119 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ LG +M S+ TP+ AK + ++ + IY+VDS G M ++R RA Sbjct: 120 EAAKSLGYFVALNVMKSYTVTPDGFAKLVETVKDF-VDVIYLVDSAGHMLPEELRAYVRA 178 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA- 242 ++ + G H H+NL L VA+++ ++EG ID +L G+G GN P E +A Sbjct: 179 IQDRVG-MIALGYHGHNNLGLAVASALELLDEGVQYIDTTLTGIGRSGGNIPTETMLAVL 237 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQD------RPVRVDRETLALGYAGVYSSFLRHCE 296 A K G Q+ +D + L + R ++ + + E + GYAG +SS+ Sbjct: 238 AKKYGVQYCSDDFLLQTLG--VARQFREYVLSKGKSLDFRSEDILFGYAGFHSSYEDLLR 295 Query: 297 TAAARYGLSAVDILVELGKRRMVGGQEDMIVDV 329 A R G ++++ +R V E ++ D+ Sbjct: 296 REAERQGQDFHQAILDVSRREQVCLTEAILTDI 328 >UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legionella pneumophila RepID=Q5ZS38_LEGPH Length = 295 Score = 100 bits (248), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 70/235 (29%), Positives = 113/235 (48%), Gaps = 4/235 (1%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D +LRDG H + +++++I LD++ ++ IE+ + +G N G Sbjct: 6 ILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQ 65 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 +++ ++K AKIA ++ P DL G +++R+ + + I+ A+ Sbjct: 66 DYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPLIKLAK 125 Query: 128 ELGMDT-VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 L +T V + +S+ T E L + + + IY DS G++ I ++ Sbjct: 126 NLNFETSVNIIHISYYTESE-LDSLIEEVSEHEPDMIYFADSNGSLFPDRINCLYKKYTR 184 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 + K G HAH NL L AN++AAV G IDASLAGMG G GN E FIA Sbjct: 185 QYK--VSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIA 237 >UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J6G8_9BACL Length = 322 Score = 96.3 bits (238), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/274 (24%), Positives = 134/274 (48%), Gaps = 9/274 (3%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDG---LQGSSF 57 M K I D T+RDG +S+E V+++ L++A VD +E+ + + L+G+ Sbjct: 1 MKANKCKIVDCTIRDGGLVNNWDFSVEFVQKLYAGLNEAGVDYMEIGYKNSPKLLKGAD- 59 Query: 58 NYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD 117 G D +++ K++ L+ G +D+ ++ ++RVA + + D Sbjct: 60 EAGPWRFLDDDFLRKVIPQKGTTKLSALVDIGRVDENDILPRSESLLDLIRVACYIKDVD 119 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + Q +Q + G +T +M L + ++++ +Y+VDS G+++ D+ Sbjct: 120 KALQLVQLFHDRGYETTLNIMALSNVMEHELLEAFEMIKDSVVDVVYIVDSYGSLDYKDM 179 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 K L P + G+H H+N+ L +N++ A E G + +DAS+ GMG AGN P E Sbjct: 180 EHLVNKFKTHL-PGKRLGVHTHNNMQLAFSNTLVAAENGVELLDASVYGMGRAAGNCPTE 238 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 + + ++ L +++ ++L+ PL+++ Sbjct: 239 LLVTHLKGTNYK----LRPVLEVLEELLIPLREK 268 >UniRef50_C1BE00 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus opacus B4 RepID=C1BE00_RHOOB Length = 201 Score = 96.3 bits (238), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 48/68 (70%), Positives = 52/68 (76%) Query: 88 PGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPEN 147 PGIGTI +LK G R VRVATH TEADVSAQHI ARELGMD G LMMSHM +P + Sbjct: 134 PGIGTIDELKLVHSLGVRSVRVATHATEADVSAQHISAARELGMDVSGVLMMSHMASPTH 193 Query: 148 LAKQAKLM 155 LA+QAKLM Sbjct: 194 LAEQAKLM 201 >UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legionella RepID=C6N5U6_9GAMM Length = 302 Score = 95.9 bits (237), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/266 (28%), Positives = 129/266 (48%), Gaps = 15/266 (5%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ + D +LRDG H + + +I ALD + ++ IE+ + +G N G Sbjct: 2 NKKIQLLDASLRDGGHRTNFHFQDGALEEILPALDRSGIEYIEIGYRNGSLHPINNLGRA 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D E++ ++ +AK+A + P DL G ++R+ + Sbjct: 62 GWCDKEYLLFCRALILNAKMAVMAHPENVNQDDLLELKNCGVDLLRICIAKDHFSSAIPV 121 Query: 123 IQYARELGMD-TVGFLMMSHMTTPE--NLAKQAKLMEGYGATCIYVVDSGGAM---NMSD 176 I+ A+++G++ ++ F+ +S+ T E + +A L + IY DS G++ +++ Sbjct: 122 IKIAKQIGLEVSINFIHISYYTNAELDAVIAEASLQQ---PDIIYFADSNGSLLPSRINE 178 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 I DR+ A G HAH N+ L AN++AA+ G IDASLAGMG G GN Sbjct: 179 IYDRYINQYA-----IPFGFHAHDNIGLAQANALAAMNAGVHFIDASLAGMGKGTGNLKT 233 Query: 237 EVFIAAADKLGWQHGTDLYALMDAAD 262 E FIA + + DL+ ++ AA+ Sbjct: 234 EFFIAYLHAINIKK-YDLHDILYAAN 258 >UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q8KT71_PHOLU Length = 312 Score = 93.2 bits (230), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 107/233 (45%), Gaps = 4/233 (1%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 DVTLRDG + ++ E + +AL + V+ E+ + +G N G S + Sbjct: 6 DVTLRDGGYLNNFNFTTEYAIKHVEALTKSGVEWFEIGYRNGSFKPISNIGLTGMSPDSY 65 Query: 70 IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAREL 129 I V AK+ + P D+ G ++R+ + + AR Sbjct: 66 IRDIHQSVPEAKLVVIAHPHNINADDIYAMKTNGVSLLRLCIKADNPQPCLELCEIARAT 125 Query: 130 GMDT-VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAEL 188 GM + F S ++ + + + AK E GA IY+ DS G++ + F LK+ Sbjct: 126 GMAVGINFTRASQLSISK-IIEIAKQCEQAGADIIYLADSNGSLFPEQVAQMFYKLKS-- 182 Query: 189 KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 + Q G H H NL L ANSI A+ G + ID+SL+GMG GAGN LE +++ Sbjct: 183 ATQVQLGFHPHDNLGLATANSIEAMRAGVNFIDSSLSGMGKGAGNLNLESWLS 235 >UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJA2_FIBSS Length = 313 Score = 92.0 bits (227), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 127/268 (47%), Gaps = 10/268 (3%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNYGFGAHSD 66 + D T+RDG +H +SLE VR++ L A VD +E+ + + + YG D Sbjct: 8 VLDCTIRDGGLVNKHDFSLEFVRRLYTLLTAAGVDYMEMGYKNSPELFDPKEYGPWKFCD 67 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIH--DLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 + + D + +K+ ++ +G ++ +K A ++ ++ RVA++ D + Sbjct: 68 DDLLWKVKDGID-SKMKMAVMADVGRVNMDAVKPASESPYQMFRVASYVKNIDKGISMVN 126 Query: 125 YARELGMDT-VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 ++G +T + + +S PE ++ E A +Y+VDS GA DI Sbjct: 127 AFHDMGYETTLNIMAVSRDRGPELDEALHQVNEECKADVLYLVDSFGAFYQEDIDKELAR 186 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 K +K + G H H+N L +N+I A+ D +D S++GMG GAGN E+ + Sbjct: 187 YKGIVK-NKKFGFHGHNNQQLAFSNTIQAIINHVDYLDGSVSGMGRGAGNCTTELLLGFL 245 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDR 271 + DL ++DA +L PLQ + Sbjct: 246 KNPKY----DLRPVLDAIQELFLPLQSK 269 >UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWI0_PAESJ Length = 320 Score = 89.7 bits (221), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/276 (25%), Positives = 134/276 (48%), Gaps = 11/276 (3%) Query: 1 MNGKKLY--ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDG---LQGS 55 MN K + I D T+RDG +S+E V+ + L++A VD +E+ + + L+G+ Sbjct: 1 MNSKTSHCKIVDCTIRDGGLVNNWDFSVEFVQHLYNTLNEAGVDYMEIGYKNSPKLLKGA 60 Query: 56 SFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 G D +++ + K++ L+ G +D+ ++ ++RVA + + Sbjct: 61 D-TAGPWRFLDDNFLKQVIPNKGNTKLSALVDIGRVDENDILPRSESLLDLIRVACYIQD 119 Query: 116 ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMS 175 D + Q +Q E G +T +M L + +L++ +Y+VDS G++ + Sbjct: 120 VDKALQLVQLFHERGYETTLNIMALSNVMENQLIEAFELIKESVVDVVYIVDSYGSLKPN 179 Query: 176 DIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 D + L P + G+H H+N+ L AN++ A E+G + +DAS+ GMG AGN Sbjct: 180 DYSYLIEKFQHHL-PNKRLGIHTHNNMQLAFANTLLAAEKGVELLDASVYGMGRAAGNCN 238 Query: 236 LEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 E+ +A + ++ ++D + + PL+++ Sbjct: 239 TELLVANLQNAKY----NVRPVLDMIEKYMIPLREK 270 >UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=C5S7B1_CHRVI Length = 327 Score = 88.2 bits (217), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 120/244 (49%), Gaps = 7/244 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNYGFG 62 +L + D T+RDG HQ+S + VR + +A +A +D +E+ + + + +G Sbjct: 12 PELKVLDCTVRDGGLVNAHQFSDDFVRAVYRACVEAGIDYMEIGYKNSPKVFPKEKFGPW 71 Query: 63 AH---SDLEWIEAAADVVKHA-KIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEAD 117 H +DL+ + D K K+A + G + A ++ ++RVA + + Sbjct: 72 RHCDEADLKRVVGDHDPEKTGLKLAAMADAGKSDWETQIVPAAESPLSMIRVAFYAHQVS 131 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + I+YA +LG +T LM T + + + AT + +VDS G + I Sbjct: 132 EAVDMIRYAHDLGYETTANLMAVSNITEAEIDTVLESIAPTPATTMVIVDSFGYLYREQI 191 Query: 178 RDRFRALKAELKPE-TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 +R + L+ + G+HAH+NL L AN+I A+ GC+R+DA++ G G GAGN Sbjct: 192 DRLYRKYTSALEGTGKEIGIHAHNNLQLAFANTIEAIILGCNRVDATMYGFGRGAGNCHT 251 Query: 237 EVFI 240 E+ + Sbjct: 252 ELLL 255 >UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001788D72 Length = 321 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 126/267 (47%), Gaps = 9/267 (3%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDG---LQGSSFNYGFGAH 64 I D T+RDG +S+E V+ + L++A VD +E+ + + L+G+ G Sbjct: 9 IVDCTIRDGGLVNNWDFSVEFVQNLYAGLNEAGVDYMEIGYKNSPKLLKGAD-QAGPWRF 67 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D E++ K++ L+ G D+ ++ ++RVA + + D + +Q Sbjct: 68 LDDEFLREVIPHKGKTKLSALVDIGRVDEDDILPREESLLDLIRVACYIKDVDKALALVQ 127 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 + G +T +M L + +++ +Y+VDS G+++ D+ Sbjct: 128 TFHDRGYETTLNIMALSNVMENELLEAFEMIRESVVDVVYIVDSYGSLDHKDMEYLVNKF 187 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 K L P + G+H H+N+ L +N++ A + G + +DAS+ GMG AGN P E+ + Sbjct: 188 KTHL-PNKRLGVHTHNNMQLAFSNTLVAADLGVELLDASVYGMGRAAGNCPTELLVTHLK 246 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDR 271 ++ L ++D + + PL+++ Sbjct: 247 GTKYE----LRPVLDIIERFMIPLREK 269 >UniRef50_A2U042 HMGL-like protein n=1 Tax=Polaribacter sp. MED152 RepID=A2U042_9FLAO Length = 516 Score = 85.5 bits (210), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 119/260 (45%), Gaps = 29/260 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHG----DGLQGSSFN 58 K I D TLRDG + + E V+ +++ +D +EV + +G G F Sbjct: 2 NKTFKILDCTLRDGGYYTNWDFDRELVKTYCSSMESLPIDYVEVGYRSIPLEGYLGEYFY 61 Query: 59 YGFGAHSDLEWIEAAADVV--------KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVA 110 +L+ + + +V + + + LL P G I ++R+A Sbjct: 62 CPDFVMKELKQMMPSKKLVIILNEKDIRASHVPELLKPCQGYI-----------SMIRIA 110 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC--IYVVDS 168 + + + + + +G + V F +M +M+ + L+E + Y+VDS Sbjct: 111 VDPANFERAIELAKAIKVMGFE-VAFNVM-YMSEWKEDNSFLDLLEDLDSIIDYFYMVDS 168 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + D++D R +K+ K Q G H H+NL + +AN+I A+ EGC+ +DA++ GMG Sbjct: 169 FGGVFQDDVKDIIRLVKS--KTNVQLGFHGHNNLEMALANTITAINEGCEIVDATITGMG 226 Query: 229 AGAGNAPLEVFIAAADKLGW 248 GAGN E+ I + G+ Sbjct: 227 RGAGNLRTELLITFLNSKGY 246 >UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=Q4ZRW6_PSEU2 Length = 342 Score = 85.1 bits (209), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 81/268 (30%), Positives = 125/268 (46%), Gaps = 5/268 (1%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I DVTLRDG + ++ + + I L +A VD E+ + G +G + Sbjct: 6 ILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDVGA 65 Query: 68 EWIEAAADVVK-HAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYA 126 +IE A K ++A ++ P T DL + G ++RV + D + A Sbjct: 66 VFIEKIAQAAKGRIELAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLSLA 125 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 R+ G + TP ++ A EG GA + DS G M +D+ F L + Sbjct: 126 RDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLFSRLSS 185 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 L G HAH+NLSL +AN+ AA+E G + ID S+ GMG GAGN L + +A ++ Sbjct: 186 RLL--VPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYLERT 243 Query: 247 GWQHGTDLYALMDAADDLVR--PLQDRP 272 G HG DL +++ ++ R P + P Sbjct: 244 GVSHGYDLVKVIELSEATARAIPQNNMP 271 >UniRef50_UPI0001AECE16 pyruvate carboxyltransferase n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AECE16 Length = 109 Score = 84.3 bits (207), Expect = 6e-15, Method: Composition-based stats. Identities = 40/65 (61%), Positives = 44/65 (67%) Query: 46 VAHGDGLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR 105 +AHG+GL GSS YG GAH+D EWIEA DVV A TLLLPGIGT HDL+ G R Sbjct: 2 IAHGEGLSGSSITYGVGAHTDWEWIEAVCDVVTRAVPTTLLLPGIGTPHDLRQTHTLGIR 61 Query: 106 VVRVA 110 V VA Sbjct: 62 SVHVA 66 >UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK Length = 534 Score = 81.3 bits (199), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 96/351 (27%), Positives = 149/351 (42%), Gaps = 65/351 (18%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG + +S + Q A+ A + +IE+ L+ SSF+ Sbjct: 5 DCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELGL-RSLKNSSFS----------- 52 Query: 70 IEAAADVVKHAKIATLLLPGIGTIHDL--------KNAWQAGARV-------------VR 108 A A ++TL LP TI + KNA Q ++ VR Sbjct: 53 --GACAYTTDAFLSTLDLPPSMTIGVMVNGSELVGKNAGQQALQLLFPSPASESPVDLVR 110 Query: 109 VATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQ-AKLMEGYGATCIYVVD 167 +A H E + + +E G D VGF +M E+ K AKL Y +Y D Sbjct: 111 IACHVHEFAEALPAASWLKERGYD-VGFNLMQIANCSESEIKALAKLANNYPLDVLYFAD 169 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 S G+M+ D + L++E + G+H H NL L ++N++ A++EG +D+++ GM Sbjct: 170 SMGSMSPDDAAQIIQWLRSEW--QGALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGM 227 Query: 228 GAGAGNA---PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY 284 G G GNA L + IAA + +L LM + +P+Q + G+ Sbjct: 228 GRGPGNARTEELAIEIAARTR----KPANLIPLMTLLREHFKPMQ----------VKYGW 273 Query: 285 AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 +L A +YG+ I LG R G+ED++ + LRN Sbjct: 274 GTNPYYYL------AGKYGIHPTYIQEMLGDSRF--GEEDILAVIEY-LRN 315 >UniRef50_Q4HR83 4-hydroxy-2-ketovalerate aldolase, putative n=2 Tax=Campylobacter RepID=Q4HR83_CAMUP Length = 330 Score = 80.5 bits (197), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 116/256 (45%), Gaps = 11/256 (4%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG H ++ E +RQI L +A +D IEV LQ F + + Sbjct: 5 ILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGL---LQNHQCGVDFSIFNSI 61 Query: 68 EWIEAAADVV--KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 ++++ + K++K + +L + L A +R+A + + ++ + Sbjct: 62 DFVDQCLSSIEKKNSKFSLMLRTDRVDFNKL--AKSPKVDFIRIALYQEHLNDIKRYGEK 119 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 A+ELG + + + +P + K +E I +VD+ G+ +++ + Sbjct: 120 AKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLVDTFGSFTLNEFEKVLKIFD 179 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIAA 242 L P G+H H NL+L ++ + A + +R ID+SL+GMG GN E+F Sbjct: 180 KNLSPNITLGIHLHQNLNLALSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELFANY 239 Query: 243 ADKLGWQHGTDLYALM 258 ++ + H ++ L+ Sbjct: 240 LNQ-NFNHQYNIEKLL 254 >UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C68 RepID=D0ANI5_ENTFC Length = 527 Score = 80.5 bits (197), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 112/245 (45%), Gaps = 22/245 (8%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG + ++ +N ++I L ++ ++ IE G + +N ++ L Sbjct: 6 ILDCTLRDGGYCNNWEFGFDNTKKIISGLIESGIEIIEC--GFLTNKTVYNKNVTKYTTL 63 Query: 68 EWIEAAADVVKHAKIATLLLP-GIGTIHDLKNAWQAGARVVRVATH---CTEADVSAQHI 123 E + + K+ ++ G I DL + + +R+A H C EA + Sbjct: 64 EELAQIIPEKREGKLFVAMMNYGEYNIEDLPDYDGSSIDGIRIAFHKKNCNEA------L 117 Query: 124 QYARELGMDTVGFL-----MMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + RE+ G+L M+S T E K + + Y+VDS G M D+ Sbjct: 118 KLCREIKKK--GYLVFVQAMVSLNYTDEEFLAVIKNVNQFKPYAFYIVDSFGMMKGKDLT 175 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAP 235 F ++ L+ + Q G H+H+N+ L +N+ + +R ID+S+ GMG GAGN Sbjct: 176 RLFYMIEHNLEKDIQIGFHSHNNMQLAYSNAQKLITVQTNRSLIIDSSVYGMGRGAGNLN 235 Query: 236 LEVFI 240 E+F+ Sbjct: 236 TELFV 240 >UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FUY3_9FIRM Length = 431 Score = 78.6 bits (192), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/239 (25%), Positives = 109/239 (45%), Gaps = 14/239 (5%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG + ++ +N+ I + L DA VD IE+ D + F+ + Sbjct: 8 DCTLRDGGYVNDWKFGHDNLVGIFERLVDANVDIIEIGFLDDRR--PFDIDRSIMPNTAC 65 Query: 70 IEAAADVVKHAKIATLLLPGIGT-----IHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 E V+H + + + GT I +++ G RV+ EA ++ + Sbjct: 66 AEKIWKDVEHKNVMVVGMIDYGTCDISNIQPCCDSFLDGIRVIFKEHLMKEA---MEYCR 122 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 ++LG L+ T E++ + +L+ + +VD+ G + + + + + L Sbjct: 123 QIKKLGYKVFAQLVSVTTYTKESMLELIELVNDVKPYAVSMVDTYGLLKPNTLLEYYEIL 182 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR----IDASLAGMGAGAGNAPLEVF 239 + PE Q G HAH+N L AN++A V + + +D +L GMG AGNAP+E+ Sbjct: 183 DEYVYPEVQIGFHAHNNFQLAYANALAFVSKPNKKHDIVVDGTLFGMGKSAGNAPIELL 241 >UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LXD4_9FIRM Length = 538 Score = 78.6 bits (192), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/270 (26%), Positives = 126/270 (46%), Gaps = 13/270 (4%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G++L + D TLRDG + ++ + + +I + L + V+ IEV D + SSF+ G Sbjct: 2 GERLLL-DCTLRDGGYVNNWEFGYDRIVEIFERLVSSGVEFIEVGFLD--EKSSFDRGRT 58 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGT--IHDLKNAWQAGARVVRVATHCTEADVSA 120 D + + V L + GT I L+ + +RV ++ + + Sbjct: 59 VLPDTASVSRMFEGVSKGDALVLGMIDYGTCSIERLEPCEETFLDGIRVIFKESKMEAAL 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + ++LG ++ T E LA+ AKL+ +VD+ G ++ + Sbjct: 119 KFYAEVKKLGYKVFAQMVSVTTYTDEKLAEYAKLVNEVMPYATSMVDTYGLLDEEHLCHI 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLE 237 + L A L P+ + G HAH+N LG AN+ + +R D +L GMG AGNAPLE Sbjct: 179 YGILDANLDPQIRVGYHAHNNFQLGYANAKHFLSLDSERGLLADGTLYGMGKSAGNAPLE 238 Query: 238 VFIAAADKLGWQHGT--DLYALMDAADDLV 265 + + +K + G D+ +++A D+++ Sbjct: 239 LLMMFRNK---KQGARYDVNQVLEAIDNVI 265 >UniRef50_B1T1D8 Pyruvate carboxyltransferase n=1 Tax=Burkholderia ambifaria MEX-5 RepID=B1T1D8_9BURK Length = 304 Score = 75.1 bits (183), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 69/238 (28%), Positives = 107/238 (44%), Gaps = 8/238 (3%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH--GDGLQGSSFNYGFGAHSDL 67 D TLRDG + H +S + I L + VD IEV + L+ + H+ L Sbjct: 18 DCTLRDGGYINDHDFSAPQIDAILTRLIASGVDVIEVGYFRRRNLERHAATIAHCPHAFL 77 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 + A V + ++ PG DL VVR D +A + A+ Sbjct: 78 ASLARQAPV----RYGVMVPPGDVEAADLDELADLPVSVVRFTCTDRNLDKAAALGERAK 133 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 LG+ T G + +P LA+ + + G +Y DS GA++ +D+ D ++ Sbjct: 134 RLGLTTCGNITRVSECSPAQLAEVTRTLAAAGFDTLYAADSNGALHPTDVTDIVGEMRRH 193 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 Q G HAH +L L VAN++AA+ G +D ++ G+G G GNA +EV +A K Sbjct: 194 FT--GQLGFHAHDSLHLAVANALAAMSAGASWVDGTIGGVGKGGGNAAIEVLLAEVSK 249 >UniRef50_C5CLY8 Pyruvate carboxyltransferase n=1 Tax=Variovorax paradoxus S110 RepID=C5CLY8_VARPS Length = 313 Score = 73.2 bits (178), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 136/304 (44%), Gaps = 41/304 (13%) Query: 1 MNGKK-LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ K+ ++I+DV RDG+ + E ++ + L +A + SIE A + + Sbjct: 1 MSAKEAIHITDVAPRDGLQNQAIRVGTEGKLRLIELLAEAGLRSIEAA--SFVSPKAVPQ 58 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA--- 116 A L ++A + A + T +L + + L+ A AGA+ + V TE Sbjct: 59 MADAGELLPQVQA-----RFAALRTSVL--VPNLKGLERAHAAGAKEIAVVLSATETMNR 111 Query: 117 -----------DVSAQHIQYARELGMDT-----VGFLMMSHMTTP-ENLAKQAKLMEGYG 159 +VS Q I AR LG+ T V F TP + + + + M Sbjct: 112 KNINMGLDQATEVSEQTIAAARALGLRTRAYVAVAFDCPFEGETPLDEVLRLSARMHAAA 171 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 A I + D+ G+ + +++R AL+ + P + +H H +GVAN+ AA+E G R Sbjct: 172 ADEIVIADTIGSASPGQVKERILALRG-VVPIERLAVHLHDTRGMGVANAWAALEAGVRR 230 Query: 220 IDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA----DDLVRPLQ 269 DAS+ G+G AGN E + A++ G+ G L L+ A D+L RPL Sbjct: 231 FDASVGGIGGCPFAPGAAGNLATEDLVLMAERSGFATGISLAGLLAAVDFAQDELQRPLG 290 Query: 270 DRPV 273 R + Sbjct: 291 GRAI 294 >UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MS84_9FIRM Length = 528 Score = 71.2 bits (173), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 8/242 (3%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG + ++ EN++ + L A +D IE + F+ Sbjct: 2 KRIRILDCTLRDGGYINNWKFGYENIKDTVRRLIQAGIDIIEAGYLSS--KGDFSADESQ 59 Query: 64 HSDLEWIEA--AADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 +S ++ I+ AD K+ IA ++ G L G +RV H ++A + + Sbjct: 60 YSSVDAIKRILPADR-KNTLIAVMINCGDYDAELLPQYDGTGPDCIRVCFHKSQALQAVE 118 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 + +E G M++ + + + Y+VDS G+M D+ F Sbjct: 119 LCRKIKEKGYKVYFQPMVALSYSDAEYLGLIGMANKFRPDGFYIVDSHGSMKQKDVARFF 178 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEV 238 ++ L E G H+H+NL L +N+ D ID+S+ GMG GAGN E+ Sbjct: 179 YLIENNLDKEIAVGFHSHNNLQLSYSNAQYLTALHTDHNLIIDSSIMGMGRGAGNLNTEL 238 Query: 239 FI 240 F+ Sbjct: 239 FV 240 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 70.9 bits (172), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 115/264 (43%), Gaps = 43/264 (16%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG A +S+++ + +ALD +D IE G GS+ Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEA----GNPGSN-------P 51 Query: 65 SDLEWIEAAADV-VKHAKIATL-------LLPGIGTIHDLKNAWQAGARVVRVA-----T 111 DLE+ E V +KH+K+ + P +L + QAG V + Sbjct: 52 KDLEFFELVKSVELKHSKLVAFGSTRRKDVAPE--EDQNLISLLQAGTEYVSIFGKSWDF 109 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMS--------------HMTTPENLAKQAKLMEG 157 H T D+ ++ E+ DT+ FL + PE + K + Sbjct: 110 HVT--DIIKTTLENNLEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYALEALKAAKD 167 Query: 158 YGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 GA + + D+ G +I + +K +L + + G+HAH+++ GVANSIAAVE G Sbjct: 168 GGAEILTLCDTNGGCFPEEISRITKEVKEKL-GDIKIGIHAHNDMGFGVANSIAAVEAGA 226 Query: 218 DRIDASLAGMGAGAGNAPLEVFIA 241 ++ + G G GNA L IA Sbjct: 227 LQVQGTFLGYGERCGNANLSTIIA 250 >UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVP8_9CLOT Length = 336 Score = 70.1 bits (170), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 60/270 (22%), Positives = 119/270 (44%), Gaps = 13/270 (4%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVA---HGDGLQGSSFNYGF 61 K+++ D TLRDG + ++ ++I L + + IE+ HG + S+ F Sbjct: 3 KIHLLDCTLRDGGYVNNWEFDNGVAKEIVNGLYKSGIHVIEIGIMGHGGKVGKST---KF 59 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 + + E + + K K A +L D+ + ++R+A +E + Sbjct: 60 ASFKEAESL--LENRKKDCKYAIMLNQAEAASFDIPARSEKTVDMIRLAYFKSEFQNAIV 117 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 + ++ G + M + M + + + + + Y+VDS + DI Sbjct: 118 LAKSLKDKGYEVFLQAMATFMYSDDEMNDMLRQINDMKPKAFYIVDSFSNLFPEDIARMA 177 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEV 238 + + +L + G HAH+N+ + +N+I ++ DR ID S+ GMG GAGN P+E+ Sbjct: 178 KQVLLKLDKDIDFGFHAHNNIQMAFSNAITFMDVESDRDIYIDGSIYGMGRGAGNVPIEL 237 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPL 268 + +K + +L L+ D ++P+ Sbjct: 238 LMDYLNKK--EKLYNLEVLLKTYQDYIKPI 265 >UniRef50_D0LRX4 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LRX4_HALO1 Length = 311 Score = 70.1 bits (170), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 114/232 (49%), Gaps = 20/232 (8%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS-DLE 68 DVTLR+ A + + +++ +A+ L A++D +E+ + ++ +++ A + Sbjct: 6 DVTLREVGEASGYAFDIDDAIGLAQQLSAAKLDGVEIGY---VRPRAWSGPPSAQTCSPT 62 Query: 69 WIEAAADVVKHAKIATLL----LPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 +IE + A++A + +P G + L+ G ++R+A ++ + Sbjct: 63 YIERLRQALGSARLAVFVHLHEIPAGGLVA-LR---PLGVDLIRLAVAADRPEILRERAA 118 Query: 125 YARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 R LG++ +V + M+ P + + ++ E GA+ YV DS G++ F Sbjct: 119 ELRALGIEFSVNAIRMTE-HEPARIVELGRIAEDVGASMFYVADSNGSLYPL----LFAK 173 Query: 184 LKAELKPETQT--GMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 L A+L+ E G H H NLSL +AN+I A+ G + ID SLAG G G GN Sbjct: 174 LAAQLRTELSIPLGAHLHDNLSLAMANAIVALSHGFEWIDGSLAGAGKGGGN 225 >UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter lovleyi SZ RepID=B3E4J8_GEOLS Length = 531 Score = 70.1 bits (170), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 107/243 (44%), Gaps = 13/243 (5%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG + L +++ I LD A VD +E+ D + S++ Sbjct: 2 KSIQILDCTLRDGGFVNDWNFGLGSMKSIISRLDKAGVDMVEIGFID--ERRSYDPNRAI 59 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGI---GTIHDLKNAWQAGARV--VRVATHCTEADV 118 D + +A V++ I L+ G+ GT K A + + + +RV + D Sbjct: 60 QPDTQSFQA---VLQGLDIRNSLILGMVDYGTCDIDKIAPKEHSYIDGIRVIFKKKDQDA 116 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + +++Q + G + + E + + G + +VD+ G M+ D+ Sbjct: 117 ALRYLQQIKAKGYKIYVNPVSITGYSDEEICSLIGKINGLDPEGVSIVDTYGLMHRKDLL 176 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAP 235 FR L G HAH+N L ANSI E +R ID+SL GMG GAGNA Sbjct: 177 HYFRLFDKYLSNHITLGYHAHNNFQLVYANSIELCELLGERNIIIDSSLYGMGKGAGNAN 236 Query: 236 LEV 238 E+ Sbjct: 237 TEL 239 >UniRef50_C4Z863 HMGL family protein n=4 Tax=Bacteria RepID=C4Z863_EUBR3 Length = 323 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 3/138 (2%) Query: 106 VVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 +VRVAT+ + + + I+ A+ G + +M T +L + ++ A IY+ Sbjct: 117 MVRVATYVHQMPAAIEMIEDAKSKGYEVTCNIMAISNTQESDLDQALDMVAKSSADGIYI 176 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQ--TGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 VDS GA+ IR R E+ GMHAH+N L AN+I A +G +DA+ Sbjct: 177 VDSYGALYPEQIR-RIAEKYTEIAEANGKFVGMHAHNNQQLAFANTIEAAAQGVSLLDAT 235 Query: 224 LAGMGAGAGNAPLEVFIA 241 + GMG GAGN +E+ ++ Sbjct: 236 MMGMGRGAGNCAMELLLS 253 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 69.3 bits (168), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 102/237 (43%), Gaps = 4/237 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ + D TLRDG + +IA LD VD IE +G + Sbjct: 15 MQSKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVK 74 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA-DVS 119 +++ L+ V I +G +H R+ + E ++ Sbjct: 75 SISNAGLDTTVCGLARVLKKDIDACFESDVGLVHTFVPTSDV-QRIYTIKKSREEVIQLA 133 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 + +QY ++ G+ + M + T PE L + K ++ G I V D+ G M S + Sbjct: 134 VEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYR 193 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 + + + AE+ +H H++ L VANS+ AVE G ++ ++ G+G AGNA L Sbjct: 194 QIKGIAAEIT--IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADL 248 >UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B5W6H6_SPIMA Length = 548 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 85/328 (25%), Positives = 141/328 (42%), Gaps = 26/328 (7%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG + + V A++ A VD +E+ L+ F G A++ ++ Sbjct: 18 DCTLRDGGYYNAWDFPRHIVIDYLNAMEAAGVDIVELGF-RSLKNQGFK-GACAYTTDDF 75 Query: 70 IEAAADVVKHAKIATLL--------LPGIGTIHDL--KNAWQAGARVVRVATHCTEADVS 119 + + + + I ++ +P T+ L + A + R+VR A H E Sbjct: 76 LRSLP-LPERLTIGVMVNGAELLGDMPLEQTLEHLFPETAATSPVRLVRFACHIHEFQQV 134 Query: 120 AQHIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + +E G VGF LM P+ + ++ Y +Y DS G+MN Sbjct: 135 LPASTWLKERGFQ-VGFNLMQVADRLPQEIETLSQQACNYPLDVLYFADSMGSMNPQHTL 193 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 + L+ + G+H H N+ + + N++ A+E G +DA++ GMG G GNA E Sbjct: 194 EIINRLRTHW--QGALGIHTHDNMGMALQNTLQALEAGVTWLDATVTGMGRGPGNAKTEY 251 Query: 239 FIAAADKLGW--QHGTDLYALMDAADDLVRPLQDRPVRVDRETLAL-GYAGVYSSFLRHC 295 A +LG Q L LM + RPLQ+ L G G++ S+++ Sbjct: 252 L---ALELGQRRQKPCSLVRLMSLIEGFFRPLQNTHGWGTNTYYYLAGKHGIHPSYIQSM 308 Query: 296 ETAAARYGLSAVDILVELGKRRMVGGQE 323 +RY S DIL + R+ GG++ Sbjct: 309 -LGDSRY--SPEDILAVIEHLRVEGGKK 333 >UniRef50_C4Z4L3 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z4L3_EUBE2 Length = 326 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 109/242 (45%), Gaps = 13/242 (5%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV---AHGDGLQGSSF-NYGFGA 63 + D TLRDG +++ E V+ + +A A VD +E A D F + F Sbjct: 17 VMDCTLRDGGLVNNFEFTDEFVKDLYEANVAAGVDYMEFGYKADKDIFDEKEFGKWKFCK 76 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTI-HDLKNAWQAGARVVRVATHCTEADVSAQH 122 D+ I D KI+ + G + D+ ++ +VRVAT+ + + Sbjct: 77 EEDIRAIVGENDT--PLKISVMADVGRTNMKRDIPPKSESVVDMVRVATYINTIPAAIEM 134 Query: 123 IQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR--- 178 Y ++G + TV + +S E L A IY+VDS G++ +R Sbjct: 135 ANYCSDMGYEVTVNIMAISTAGENELDLALELLASQSKAQYIYLVDSYGSLYPEQVRRLA 194 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 D++ +K K G+HAH+N L AN+I A G +DA+++GMG GAGN E+ Sbjct: 195 DKY--IKIAEKYGKSVGIHAHNNQQLAFANTIEACSIGVSLLDATVSGMGRGAGNCYSEL 252 Query: 239 FI 240 + Sbjct: 253 LL 254 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 38/261 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + +L ++A AL D VD IE + + Sbjct: 16 RQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAG-----------FPIAS 64 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 D E + A ++ A I L D+ AW+A + H A SA H Sbjct: 65 PGDFESVRQIATTIRGATICGL---ARCAEKDIDRAWEALKTAPQARIHVFLA-TSAIHR 120 Query: 124 QYARELGMDTVGFLMM-------SHMT----TPENLAKQ-----AKLMEG---YGATCIY 164 ++ + D + + SH +PE+ + +++E GAT I Sbjct: 121 EFKLRMTPDEIVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTIN 180 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGM---HAHHNLSLGVANSIAAVEEGCDRID 221 V D+ G +I DRF+ L+ + P + H H +L + VANS+AAV+ G +I+ Sbjct: 181 VPDTVGYTTPGEIYDRFKMLRDRV-PNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIE 239 Query: 222 ASLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGNA LE + A Sbjct: 240 CTINGIGERAGNAALEELVMA 260 >UniRef50_Q12KS9 Pyruvate carboxyltransferase n=2 Tax=Gammaproteobacteria RepID=Q12KS9_SHEDO Length = 539 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 116/251 (46%), Gaps = 20/251 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVA----HGDGLQGS---- 55 K I D TLRDG + + E V A+ +++D +E+ G G Sbjct: 2 KNFSILDCTLRDGGYYNNWDFCPEVVSAYLDAMAKSKIDYVELGLRNFPKKGFDGPFAYT 61 Query: 56 --SFNYGFGAHSDLEW-IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 SF G G S + + A V A + + I + +A ++ ++VRVA H Sbjct: 62 TESFLKGLGLPSGPTYGVMVDAKTVLDAPMT--IEQAIDKL--FVDASKSPIKLVRVAAH 117 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGAT-CIYVVDSGG 170 E + S ++ + G VG+ +M P E +A +AK+ + + +Y DS G Sbjct: 118 FHEVEHSGPIVKALKAKGY-IVGYNLMQAGGKPNEVIAAKAKVASQWNSLDSLYFADSLG 176 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 M+ +++ +AL+ E + G+H H+N+ + N++ A E G + +D ++ GMG G Sbjct: 177 NMDATEVTRIVKALRTEWSGDI--GIHTHNNMGKALDNTLTAKELGVNWLDVTVTGMGRG 234 Query: 231 AGNAPLEVFIA 241 AGNA E +A Sbjct: 235 AGNAQTESLLA 245 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 119/283 (42%), Gaps = 42/283 (14%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E +A+ LDD VD IE Y F + Sbjct: 11 RVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAG-----------YPFASD 59 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D E + A K++ I L I A + R R+ T + + V H++ Sbjct: 60 GDFEAVHEIAKRSKNSVICGLSRASHKDIDRCAEAIKPAERG-RIHTFLSTSPV---HMK 115 Query: 125 YARELGMDTVGFLMMSHMTTPEN-------------------LAKQAKLMEGYGATCIYV 165 Y ++ V +++S +T N L + + GAT I + Sbjct: 116 YKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINL 175 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPET---QTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ G + R+ FR ++ E P + + +H H++L + VANS+A V G +I+ Sbjct: 176 PDTVGYAVPEEYREMFRKVR-ETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIEC 234 Query: 223 SLAGMGAGAGNAPLEVFIAA----ADKLGWQHGTDLYALMDAA 261 ++ G+G AGNA LE + A DKL + + + L A+ Sbjct: 235 TINGIGERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHAS 277 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 77/263 (29%), Positives = 118/263 (44%), Gaps = 40/263 (15%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+++ I D TLRDG + +L Q+A+AL D VD IE GF Sbjct: 5 GQRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEA-------------GFA 51 Query: 63 AHS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR------VATHCT 114 A S DLE I+A V+ +A+L G D++ +W+A A R +AT Sbjct: 52 AASPGDLEAIQAVGRQVEGPIVASLSRCNKG---DIEASWKALADAPRRRCHVFLATSPI 108 Query: 115 EADV------------SAQHIQYARELGMDTVGFLMM-SHMTTPENLAKQAKLMEGYGAT 161 D S ++ ARE D V F S T E LA+ + + G Sbjct: 109 HRDFKLKLAKDEIIKRSVDGVKLARE-KFDDVEFSAEDSARTELEFLAEVVERVIEAGVG 167 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + + D+ G S + R L+ ++ + +H H++L + VANS+A V EG + Sbjct: 168 TVNIPDTVGYALPSTYAETIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQ 227 Query: 220 IDASLAGMGAGAGNAPLEVFIAA 242 ++ ++ G+G AGNA LE + A Sbjct: 228 VECTINGIGERAGNASLEEIVMA 250 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 67.8 bits (164), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 116/283 (40%), Gaps = 42/283 (14%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E IA LDD VD IE + + Sbjct: 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAG-----------FPIASD 59 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D E + A K+A I L G I A + R R+ T + + V H++ Sbjct: 60 GDFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIRPAKRG-RIHTFLSTSPV---HMK 115 Query: 125 YARELGMDTVGFLMMSHMTTPEN-------------------LAKQAKLMEGYGATCIYV 165 Y ++ V L++S +T N L + + GA+ I + Sbjct: 116 YKLQMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINI 175 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGM---HAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ G + D F+ ++ E P + + H H++L + VANS+A V G +I+ Sbjct: 176 PDTVGYAVPEEYYDLFKRVR-ETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIEC 234 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAA 261 ++ G+G AGNA LE + A DKL + + D L A+ Sbjct: 235 TINGIGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHAS 277 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 67.4 bits (163), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 113/274 (41%), Gaps = 34/274 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDG + QIAK LD VD IE +G Sbjct: 2 RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTI--HDLKNAWQAGARVVRVATHCTEADV--- 118 + E ++ A++ +AKI G+ + D+ A +A +V V ++ V Sbjct: 53 --EFEAVKEIANLGLNAKIC-----GLARVVKKDIDQAIKADVDIVHVFIPTSKIQVEHT 105 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 S ++Y + G++ + M + T + L + K +E G I V D Sbjct: 106 IKKTPDEIVQLSVDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPD 165 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G D + LK L +H H++ L AN+ AAV G D + ++ G+ Sbjct: 166 TVGIATPFRFYDMIKKLKEHLN--VPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGL 223 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA 261 G AGNAPLE +A G++ + L++ + Sbjct: 224 GERAGNAPLEEVVALLYAEGFKTNIRMEYLVETS 257 >UniRef50_B3QVI9 Pyruvate carboxyltransferase n=5 Tax=Bacteroidetes/Chlorobi group RepID=B3QVI9_CHLT3 Length = 510 Score = 66.6 bits (161), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 119/266 (44%), Gaps = 13/266 (4%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLRDG + + E V++ + + VD +E+ + L + F + Sbjct: 3 VLDCTLRDGGYYTNWDFDGELVQKYFSSFEKLPVDYLEIGY-RSLPEKEYRGRFYYLPNF 61 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV---RVATHCTEADVSAQHIQ 124 I+ + K+ +A +L +L A V+ R+A D + + Sbjct: 62 V-IDEITQLSKNKLLAIMLNEKSVQPKNLDKILDGLAPVISLIRLAVDPKNFDSALLLGE 120 Query: 125 YARELGMDTVGFLM-MSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 R+ G D LM MS E+ + + G A+ + +VDS G M ++ Sbjct: 121 AIRKRGFDVAFNLMYMSKYANDESFLGKLSSLNGL-ASYVNMVDSYGGMVPEQVKILIHN 179 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV---FI 240 +K+ + G H H+N+ L ANS+AA++ GC+ +D ++ GMG GAGN E+ ++ Sbjct: 180 VKSYCR--EAIGFHPHNNMELAFANSLAAIDAGCEIVDTTVMGMGRGAGNLRTELLLTYM 237 Query: 241 AAADKLGWQHGTDLYALMDAADDLVR 266 A+ +KL L +L++A L R Sbjct: 238 ASKNKLELDFNV-LASLIEAWMPLYR 262 >UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YPG1_9GAMM Length = 304 Score = 66.6 bits (161), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 120/288 (41%), Gaps = 42/288 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I+DV RDG+ S+E Q+ A+ D V IEV F + Sbjct: 3 ETVVITDVGPRDGLQNQPQVLSVEQRLQLVNAIADCGVPQIEVGS------------FVS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKN---AWQAGARVVRVATHCT------ 114 + + V A + P I I ++K A ++G + V + + + Sbjct: 51 PKAVPAMAGTGQVFSALDAAEFVTPTIALIPNMKGYELARESGVKTVTMVVYASDGMAQK 110 Query: 115 -------EAD-VSAQHIQYARELGMDTVGFLMMSH------MTTPENLAKQAKLMEGYGA 160 EA+ V+ ++ A+E G++ + + ++ T P + GA Sbjct: 111 NVGMSMAEAELVTLDILKLAKEDGIEVIATIAVAFECPFDGATDPAVVKNIVAKFLAAGA 170 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + + D+ GA + +R+ L A E Q G H H ++G+AN AAVE G R Sbjct: 171 DQLVLADTVGAAHPQQVRELTATLVASHGAE-QLGCHFHDTRAMGLANVYAAVESGIRRF 229 Query: 221 DASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD 262 D+S+AG+G +GN + ++G++ G DL LM A+D Sbjct: 230 DSSIAGLGGCPFSPGASGNVATDDIAMMLQQMGFKTGIDLGKLMQASD 277 >UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synechococcus sp. WH 8102 RepID=Q7U935_SYNPX Length = 540 Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 107/263 (40%), Gaps = 31/263 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSF---- 57 N + I D TLRDG + +S E + +A A++D IE+ L + F Sbjct: 3 NERTFKILDCTLRDGGYYNNWNFSDELIENYVRASLAAKIDVIEIGFRSSLN-NKFKGAC 61 Query: 58 ---------NYGFGAHSDLEWIEAAADVVKHAKIATLL-----LPGIGTIHDLKNAWQAG 103 N F +D+ + +++ + I LL P I +I Sbjct: 62 AYSSDLFLENLPFLNGTDIAVMVNGSEICRTDSIPRLLEKLFPKPAISSI---------- 111 Query: 104 ARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 +VR+A H +E ++ + G +M ++ + + + Sbjct: 112 VSIVRIACHFSELSRVLSATRWLADHGYKICINIMQISDRKYADIKEITSMASDCPIDVL 171 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 Y DS G++ DI + + E G+H H+N+ + + N++ A EEG + +D++ Sbjct: 172 YFADSTGSLKPDDISRIVEWFRTGWQREL--GIHTHNNMGIALQNTLRAYEEGVNWLDST 229 Query: 224 LAGMGAGAGNAPLEVFIAAADKL 246 ++GMG G GNA E + + L Sbjct: 230 VSGMGRGPGNAKTEELVIETETL 252 >UniRef50_Q1IEM5 Putative uncharacterized protein n=1 Tax=Pseudomonas entomophila L48 RepID=Q1IEM5_PSEE4 Length = 340 Score = 65.5 bits (158), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/183 (33%), Positives = 79/183 (43%), Gaps = 24/183 (13%) Query: 137 LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM 196 LM + TPE LA+ + T +Y DS G M + F + EL P G Sbjct: 152 LMQAAELTPEQLAQDLPALAVEPVTALYFADSFGRMLPEQVHRLFSRAR-ELTP-LPLGF 209 Query: 197 HAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYA 256 HAH N L VAN+ AA++ G D + AG+G GAGNAP E K G + + A Sbjct: 210 HAHDNYGLAVANTQAALDAGARHADGTFAGIGRGAGNAPTETL--GLLKSGTREMAECEA 267 Query: 257 LMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHC--ETAAARY-------GLSAV 307 + + + PL R T GY+ Y S RH T A R GL + Sbjct: 268 FL---AEHIEPL--------RLTANWGYSPTYRSQARHNVHPTYAQRLFEGTPLTGLERI 316 Query: 308 DIL 310 DIL Sbjct: 317 DIL 319 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 65.5 bits (158), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 52/267 (19%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + +L+ ++A+ L+ VD +E GF A Sbjct: 7 RIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEA-------------GFPAS 53 Query: 65 S--DLEWIEAAADVVKHAKIATLL--LPGIGTIHDLKNAWQAGARVVRVATHC---TEAD 117 S D E ++A A VK ++A L +P D+ AW+A V+VA + T Sbjct: 54 SQGDFEAVQAIARAVKGVEVAGLCRAMPA-----DIDRAWEA----VKVAENPRIHTFLA 104 Query: 118 VSAQHIQYARELGMDTVGFLMMSHM-------------------TTPENLAKQAKLMEGY 158 S H+QY D V + ++ + + P+ L + + + Sbjct: 105 TSPVHMQYKLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINA 164 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM---HAHHNLSLGVANSIAAVEE 215 GAT I V D+ G + R + E P + + H H++L +GVAN++AA++ Sbjct: 165 GATTINVPDTVGYAQPEEFGRLIRYV-IENTPNSHKAVFSVHCHNDLGMGVANTLAALKA 223 Query: 216 GCDRIDASLAGMGAGAGNAPLEVFIAA 242 G + + +++G+G AGNA LE + A Sbjct: 224 GARQAEVTISGIGERAGNASLEEIVMA 250 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 64.7 bits (156), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 108/255 (42%), Gaps = 35/255 (13%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLRDG + +S ++ RQIA LD+ IE GF +SD Sbjct: 60 VFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEA-------------GFPVNSDA 106 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV-----------ATHCTEA 116 E+ EA D+ T L + D++ A +G +V + H T Sbjct: 107 EF-EAVRDIASSTSTTTCGLARV-VDADIEAALDSGVEMVHTFVSTSDVQIEDSMHATRD 164 Query: 117 DV---SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 +V + + ++ E G + M + T + L + + + G I + D+ G Sbjct: 165 EVVERAVESVERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVAT 224 Query: 174 MSDIRDRFRALKAELKPET--QTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + RFRA+ ++ T + +H H + L AN++A +E G D+ S+ +G A Sbjct: 225 PT----RFRAMIEKVCAHTDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERA 280 Query: 232 GNAPLEVFIAAADKL 246 GNA E F+ A + L Sbjct: 281 GNAAYEEFVMAVESL 295 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 64.3 bits (155), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 75/259 (28%), Positives = 116/259 (44%), Gaps = 33/259 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K L I+D TLRDG A ++L IAKALD+A VD IE G G+S Sbjct: 7 KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEA--GIPAMGAS------- 57 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 IEA +V+ ++ A ++ I D+ A + GA+ V ++ + ++A+ Sbjct: 58 -----EIEAIRQIVQQSQTARVIPWCRMKISDVDKALETGAKTVHLSISSSPFQMAAKFP 112 Query: 123 --------------IQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 I YA++ G+D +VG S L ++E GA I D Sbjct: 113 DLSAADILGLCQKVISYAKDRGLDVSVGAEDASRAEI-SFLTDLLGVIEEAGAFRIRFAD 171 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G ++ + L ++ P H H +L L ANS+AA++ G ++ G+ Sbjct: 172 TLGILDPFATYEIISQLH-QISP-LDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGL 229 Query: 228 GAGAGNAPLEVFIAAADKL 246 G AGNAPLE + AA + Sbjct: 230 GERAGNAPLEQVVIAASHI 248 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 63.9 bits (154), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 113/256 (44%), Gaps = 40/256 (15%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + + +IAK L+ VD +E GF A Sbjct: 3 KINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEA-------------GFPAS 49 Query: 65 S--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 S D E + A A+ +K+A + L D+ AW A V H A S H Sbjct: 50 SQGDFEGVRAIANTIKNASVTGL---ARAKKSDIDYAWDALKEAVEPRLHIFLA-TSPIH 105 Query: 123 IQYARELGMDTV---GFLMMSHMT--------TPENLAKQ-----AKLMEGY---GATCI 163 + Y + + V M+S+ + + E+ ++ K++E GAT I Sbjct: 106 MTYKLKKTPEQVIQTAVDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVI 165 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGM--HAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G + D F+ ++ ++ + + H H +L + VAN+IAAVE G +++ Sbjct: 166 NLPDTVGYTTPQEYGDLFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVE 225 Query: 222 ASLAGMGAGAGNAPLE 237 ++ G+G AGNA LE Sbjct: 226 GTINGIGERAGNASLE 241 >UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Bacteroides vulgatus ATCC 8482 RepID=A6L7H4_BACV8 Length = 525 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 76/328 (23%), Positives = 139/328 (42%), Gaps = 17/328 (5%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + ++ +R+I + L A +D +E L+ ++ Sbjct: 3 KIQLLDCTLRDGGYINNFRFGKYAIRKILQQLTHAGLDIVECGF---LEDGEYDEDTSIF 59 Query: 65 SDLEWIEAAADVVKHAK--IATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + E I A+ +H + ++ G + L + +RV H E + + ++ Sbjct: 60 NAAEQI-ASLLPNEHGRTMFVAMVCYGEYDLSQLSPCTRNSIDGIRVTFHYDEVEGALEY 118 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + +E G + + T L + + Y+VD+ G M+ +DI F Sbjct: 119 CREIKEKGYKVFVQPVGTSSYTDIQLLHLIEKVNELQPYSFYLVDTLGLMHKNDIARFFY 178 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI---DASLAGMGAGAGNAPLEVF 239 + L G H+H+NL L +NS E DR+ DAS+ GMG GAGN E+ Sbjct: 179 LINTNLDKSINMGFHSHNNLQLSFSNSQEFFEYVGDRVISLDASIYGMGRGAGNLNTELI 238 Query: 240 I-AAADKLGWQHGTDLYALMDAADDL---VRPLQDRPVRVDRETLAL-GYAGVYSSFLRH 294 D+ G + + L++ D+ +R + V A+ G Y+S+L Sbjct: 239 ANYVNDREGHMYAIE--PLLEVVDEFIIHIRQKHEWGYTVPYYLAAINGCHPNYASYLAQ 296 Query: 295 CETAAARYGLSAVDILVELGKRRMVGGQ 322 +T A + +SA+ ++ + KR + + Sbjct: 297 KQTLAVK-EISAILHMIPVEKRSLYNKE 323 >UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular organisms RepID=A1VTK3_POLNA Length = 744 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 79/308 (25%), Positives = 125/308 (40%), Gaps = 53/308 (17%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ IS+V RDG+ +++ + + AL A V IEVA Sbjct: 31 MYSPEILISEVGPRDGLQSVKACMPTADKLRWIDALYAAGVREIEVAS------------ 78 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKN------AWQAGARVVRVATHCT 114 F L + AA+VV+HA + LPG+ + + N A AG + V + Sbjct: 79 FVPARLLPQMADAAEVVRHA----ITLPGLRVMALVPNRRGAEAALAAGVHKLTVPVSAS 134 Query: 115 EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT------------- 161 A S +++ RE ++ V + ++ +A + +G T Sbjct: 135 AAH-SLANVRRTREEMVEEVRAIAALRRDLAPHVGLEAGISTAFGCTLQGLVAEDDVIRL 193 Query: 162 ---CIY-------VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIA 211 CI + D+ G N + +R FR L+AE+ H H+ LG+AN +A Sbjct: 194 AAQCIAAGADESGLSDTVGYANPAQVRRLFRRLRAEIG-RHAGAAHMHNTRGLGLANCLA 252 Query: 212 AVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV 265 A EEG DASL G+G +GN E + + +G + G DL L+ A L Sbjct: 253 AYEEGVRTFDASLGGLGGCPYAPGASGNVVTEDLVFMFEAMGLRTGIDLEKLIAARAPLK 312 Query: 266 RPLQDRPV 273 L P+ Sbjct: 313 AGLPGEPL 320 >UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS Length = 535 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 102/260 (39%), Gaps = 35/260 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + SL + QIA+ LD D IE G S Sbjct: 2 KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIE----GGWPNPS------NP 51 Query: 65 SDLEWIEAAADV-VKHAKIATL---LLPGIGTIHD----------------LKNAWQAGA 104 +D E+ + DV +KHAKIA PGI +D +W Sbjct: 52 TDEEFFKLIKDVKLKHAKIAAFGSTRRPGILPENDPLLQALIKSEAPVKTIFGKSWDLHV 111 Query: 105 RVVRVATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGAT 161 V T D+ + Y +E + + + PE + K E A Sbjct: 112 TDVIRTTLEENLDMIESSVAYLKEHSEEVIYDAEHFFDGYKANPEYALETLKAAELGHAD 171 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 CI + D+ G +I + + K + + T G+H H++ L VANSI AV+ GC + Sbjct: 172 CIVLCDTNGGTMPWEIEEIVK--KVQTRISTPLGIHVHNDSGLAVANSIYAVKAGCVMVQ 229 Query: 222 ASLAGMGAGAGNAPLEVFIA 241 + G G GNA L A Sbjct: 230 GVVNGYGERCGNANLTTIAA 249 >UniRef50_Q24S97 Putative uncharacterized protein n=1 Tax=Desulfitobacterium hafniense Y51 RepID=Q24S97_DESHY Length = 547 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 131/302 (43%), Gaps = 43/302 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ + D T+RDG + + +E V + KA A V+ E+ G + Sbjct: 5 KQFIMLDCTVRDGGYINNWAFPIEIVASMYKASSTAGVEIFEI----GFLSEDTSLPLWR 60 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVA------THCTE-- 115 S ++ + A+I+ +L + L + G V+R+A C Sbjct: 61 QSPAWAVKQVTQEYQGAQISAILEANTVGMK-LGIPEETGIDVLRIALNKDKVVECIPKM 119 Query: 116 ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT-CIYVVDSGGAMNM 174 AD AQ +L M G+ T + KL++ G I + DS G++ Sbjct: 120 ADYKAQGYTVFVQL-MGITGY-------TDIEILNICKLLDECGYIDYINIGDSYGSL-- 169 Query: 175 SDIRDRFRALKAELKPET--QTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + +R + + +K T + G+HAH+N+ LG+AN +AAV G + +D SL GMG G G Sbjct: 170 --LPERTTEIISMMKRNTRLKVGLHAHNNMQLGMANVLAAVAAGANIVDGSLYGMGRGGG 227 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY------AG 286 N PLE+ ++ K D Y ++ D + R + +R+ R+ GY +G Sbjct: 228 NVPLELLLSYYGK----KFPDCYDVLPVLDFIDRYM----IRI-RQEFEWGYTLNNLLSG 278 Query: 287 VY 288 VY Sbjct: 279 VY 280 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 111/261 (42%), Gaps = 38/261 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + S+E +IA L +VD IE + + Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEA-----------GFPITS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIH--DLKNAWQA--GARVVRVATHCTEADVS 119 D E + A V+ IA G+ IH D++ AW+A +R R+ T +D+ Sbjct: 51 EGDFEAVSRIASEVEGPVIA-----GLARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLH 105 Query: 120 AQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 +H ++ A+ L + M + T LA+ GA I Sbjct: 106 IEHQMRSTREEILSGAAEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVI 165 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G ++ R LK + E +H H +L + VANS+A VE G +++ Sbjct: 166 NIADTVGYTTPAEFAAFLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVE 225 Query: 222 ASLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGNA LE + A Sbjct: 226 VAVNGIGERAGNASLEEVVMA 246 >UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LKZ4_9FIRM Length = 534 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 118/286 (41%), Gaps = 38/286 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I D TLRDG + ++ ++ I L+DA VD IE G Sbjct: 14 MNTTK--ILDCTLRDGGYINNWKFGGRTIKSIISNLEDAGVDIIEC-------------G 58 Query: 61 FGAHSD-------LEWIEAAADVV--KHAKIA-TLLLPGIGTIHDLKNAWQA-GARVVRV 109 F D +E AD++ K A I+ +++ + L GA ++R+ Sbjct: 59 FIRKEDHSSDSSVFSSMEQVADIIAPKKANISYAIMIEQHNHVDKLIPENDGNGADIIRI 118 Query: 110 A---THCTEADVSAQH-IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 EA V+ +H I ++ + VG + E+L K K + Y+ Sbjct: 119 TFRRKEWEEAKVAIKHLICKGYKVCVQPVGTVTYDD----ESLLKLIKDVNQIKPYAFYL 174 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDA 222 VD+ G M D+R F + L E G H+H+NL + AN+ + R +D Sbjct: 175 VDTLGVMYRHDMRRFFYLIDNNLSKEICLGFHSHNNLQMSFANAQEMMRLAKQRSIIVDT 234 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 S GMG G GN E+F +K ++ L +++ D + P+ Sbjct: 235 SCYGMGRGVGNLATELFADYVNK-TIEYRYALTPILNIVDKYLMPV 279 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 67/257 (26%), Positives = 109/257 (42%), Gaps = 40/257 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG + +L +IA+ L+ VD IE GF A Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEA-------------GFPA 48 Query: 64 HS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 S D + ++A A V++ + L D+ AW+A H A S Sbjct: 49 ASKGDFQAVQAIAQTVRNCSVTGL---SRSVQSDIDAAWEALKDGAEPRLHVFIA-TSPI 104 Query: 122 HIQYARELGMDTV------------GFLMMSHMTTPE----NLAKQAKLMEGY---GATC 162 H+QY + + V + + + + +L A ++E GA Sbjct: 105 HMQYKLRMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANV 164 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM--HAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G + D F LK ++ + + H H +L + VANS+AA+E G +I Sbjct: 165 INIPDTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQI 224 Query: 221 DASLAGMGAGAGNAPLE 237 + ++ G+G AGNA +E Sbjct: 225 EGTINGIGERAGNAAIE 241 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 109/256 (42%), Gaps = 29/256 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 L +SD TLRDG ++S+++ IAKAL DA V IE + G+ Sbjct: 16 PLILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEA-----------GFPAGSE 64 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQH- 122 ++E + V +I L G I A A R V + + +H Sbjct: 65 REIEAVRRICAEVPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHK 124 Query: 123 IQYARELGMDTVG---------FLMMSHMTTPENLAKQAKLMEGY------GATCIYVVD 167 + ++ +D +G FL ++ + + A L + Y GAT I D Sbjct: 125 LGKSKAQCLDMIGRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPD 184 Query: 168 SGGAMNMSDIRDRFRALKAELKPE-TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 + G + +R R R L A P + +H H++L L AN++AAV G D + ++ G Sbjct: 185 TLGVLTPEAVRRRVRMLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGG 244 Query: 227 MGAGAGNAPLEVFIAA 242 +G AGNA LE + A Sbjct: 245 IGERAGNAALEETVMA 260 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 61.6 bits (148), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 71/270 (26%), Positives = 115/270 (42%), Gaps = 37/270 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG S+E+ +IA LD VD IE + + Sbjct: 3 EKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIE-----------GGWPWAN 51 Query: 64 HSDLEWIEAAADVV-KHAKIATL---LLPGIGTIHD--LKNAWQAGARVVRVATHCTEAD 117 D+E+ A +V+ + A++ PG D L +AG +V + + Sbjct: 52 PKDMEFFLRAREVIWRQARLVAFGRTRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLH 111 Query: 118 VSAQ-HIQYARELGM--DTVGFLMMSHM--------------TTPENLAKQAKLMEGYGA 160 V+A A L M D+V FL+ + P+ + K GA Sbjct: 112 VTAALGTTLAENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYALETLKAAAKAGA 171 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + I + D+ G +I + ++ E+ + G+HAH++ L VAN++AAV GC ++ Sbjct: 172 SWIVLCDTNGGCLPWEIEEAVARVRQEI--QVPVGIHAHNDGDLAVANTLAAVTAGCRQV 229 Query: 221 DASLAGMGAGAGNAPL-EVFIAAADKLGWQ 249 ++ G G GNA L V K+G+Q Sbjct: 230 QGTINGFGERCGNADLCSVMPNLELKMGYQ 259 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 61.6 bits (148), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 47/261 (18%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+Y+ D TLRDG + + E IAK L+ RVD +E QG Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQGD-------- 53 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ----AGARVVRVATHCTEADVS 119 EA ++ + K ++++ G D+ ++ A ++ + + ++ Sbjct: 54 ------FEAVREISRQIKDSSVVALGRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHIT 107 Query: 120 AQHIQYAR---ELGMDTVGF-----------LMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + + ++G+D V + L + + E + + + + GATC+ + Sbjct: 108 KKFNKNPEDILQMGVDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNI 167 Query: 166 VDS---------GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 D+ GG ++ I DR + + P +H H++ L AN++AAV G Sbjct: 168 PDTVGFAVPELFGGLIHQ--IYDRLQ----NVAPHVLLSVHCHNDSGLATANTLAAVRNG 221 Query: 217 CDRIDASLAGMGAGAGNAPLE 237 ++++ ++ G+G AGN LE Sbjct: 222 ANKVECTINGIGERAGNTSLE 242 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 61.2 bits (147), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 72/267 (26%), Positives = 106/267 (39%), Gaps = 52/267 (19%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ + D TLRDG A +++ +A L D VD IE GF A Sbjct: 11 RVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEA-------------GFAAS 57 Query: 65 S--DLEWIEAAADVVKHAKIATL--------------LLPG----------IGTIHDLKN 98 S D E I A V +L LLP IH Sbjct: 58 SPGDEEAIRTIAREVVGPTFCSLSRALESDIDAAARALLPAKRKRCHIFLATSPIHRAAK 117 Query: 99 AWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY 158 + +VV +A + + YA + D V F + T ++ + + Sbjct: 118 LKKTREQVVEIAH---------KAVSYASTI-FDEVEFSPEDAIRTEQDFLHEVCIAAAE 167 Query: 159 -GATCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEE 215 GA + + D+ G +I F LKA LK P+ H H +L LGVAN++AA+E Sbjct: 168 AGARTLNIPDTVGYTTPKEIYQIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEA 227 Query: 216 GCDRIDASLAGMGAGAGNAPLEVFIAA 242 G +I+ ++ G+G AGNA LE + A Sbjct: 228 GARQIEVTINGIGERAGNAALEEVVMA 254 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 61.2 bits (147), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 67/257 (26%), Positives = 109/257 (42%), Gaps = 26/257 (10%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH-GDGLQGSSFNY 59 M +++YI D TLRDG +S+E+ + I L++ VD +E + G ++F Sbjct: 104 MARERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAF-- 161 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHD--------LKNAWQAGARVVRVAT 111 F A + K A ++ PG+ ++ + +W VR+A Sbjct: 162 -FKRRQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAVCFVAKSWDYH---VRLAL 217 Query: 112 HCTE--------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 CT A V+A + RE +D F + PE AK GA + Sbjct: 218 GCTNEENLESITASVTAARMA-GREALVDCEHFFD-GYKANPEYALACAKAAYSAGARWV 275 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G ++ A+KA + P G+HAH++ VA S+AA++ G + + Sbjct: 276 VLCDTNGGTQPLEVAAIVEAVKA-VVPGESLGIHAHNDTEQAVAVSLAAIDAGVRHVQGT 334 Query: 224 LAGMGAGAGNAPLEVFI 240 L G+G GNA L I Sbjct: 335 LNGIGERCGNANLVSLI 351 >UniRef50_D0FNJ3 Conserved uncharacterized protein n=2 Tax=Erwinia pyrifoliae RepID=D0FNJ3_ERWPY Length = 333 Score = 60.8 bits (146), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 45/146 (30%), Positives = 67/146 (45%), Gaps = 3/146 (2%) Query: 93 IHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENL-AKQ 151 IH LK + ++RVAT + D Q G LM + E + A Sbjct: 98 IHILKKPARPVIDIIRVATKFNQLDNIDQLCNIISASGYRVALNLMQIDLACEEEVTAVF 157 Query: 152 AKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIA 211 K+ +Y+ DS G+M + + LK E+ G HAH+N+ + + NS+ Sbjct: 158 EKISSIKSIETVYLADSFGSMPPQRVAELITRLK-EIT-SANIGFHAHNNMGMALINSMT 215 Query: 212 AVEEGCDRIDASLAGMGAGAGNAPLE 237 A++ G + ID + AGMG GAGNA E Sbjct: 216 AIQAGANWIDTTFAGMGRGAGNAATE 241 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 60.8 bits (146), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 108/263 (41%), Gaps = 35/263 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ + D TLRDG + +L ++A+AL + VD IE + Sbjct: 34 MTPDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAG-----------FP 82 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 + D E + A K + I L G + D+ A +A A R H S Sbjct: 83 VASKGDFESVNEIAKNTKGSVICALARSG--GVKDIAAAGEALAPAERKRIH-NFISTSP 139 Query: 121 QHIQYARELGMDTVGFLMMS-------------------HMTTPENLAKQAKLMEGYGAT 161 H++Y + +TV L+ S T P+ L + + GAT Sbjct: 140 LHMKYKLRMEPETVLELITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGAT 199 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQT--GMHAHHNLSLGVANSIAAVEEGCDR 219 I + D+ G D+ F L+ + Q H H++L L VAN++A++ G + Sbjct: 200 TINIPDTVGYATPEDMEKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQ 259 Query: 220 IDASLAGMGAGAGNAPLEVFIAA 242 ++ ++ G+G AGNA LE + A Sbjct: 260 VECTINGIGERAGNAALEEIVMA 282 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 60.8 bits (146), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 115/290 (39%), Gaps = 44/290 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG +++ IAK L VD IE + + Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPG-----------FPLTS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 D E ++ A V+ I I D+ W+A + C +S+ I Sbjct: 51 PGDFEAVQRIAREVEGPYICGF---SRAIIRDIDETWKA---IKDAQKKCFHIFISSSDI 104 Query: 124 QYARELG--------------------MDTVGFLMM-SHMTTPENLAKQAKLMEGYGATC 162 Q +LG D V + M + T E L + + GAT Sbjct: 105 QIKHQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATV 164 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G + + + ++ ++ + +H H++L + VANSI A G +I Sbjct: 165 INIPDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQI 224 Query: 221 DASLAGMGAGAGNAPLEVFI----AAADKLGWQHGTDLYALMDAADDLVR 266 + ++ G+G AGNA LE + A D LG++ G DL L + + R Sbjct: 225 ECTINGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSR 274 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 60.8 bits (146), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 128/294 (43%), Gaps = 49/294 (16%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + R +S + R+IA LDD IE GF +S Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEA-------------GFPVNS 56 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTI--HDLKNAWQAGARVVRV-----------ATH 112 D E+ EA +D+ A + G+ + D+ A +G +V V + H Sbjct: 57 DAEF-EAVSDI---AAATNTTVCGLARVVEGDIDAAIDSGVEMVHVFVSTSDVQLEDSMH 112 Query: 113 CTEADVSAQHI---QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 T + + + + ++ G++ + M + T P+ L + + + G I + D+ Sbjct: 113 ATRQEAKQRAVAAVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTC 172 Query: 170 G-AMNMSDIRDRF-RALKAELK-PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G AM S F + +KA + + + +H H + + AN++ E G ++ S+ G Sbjct: 173 GVAMPTS-----FGKTVKAVVNATDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNG 227 Query: 227 MGAGAGNAPLEVFIAAADKL-GWQHGTD------LYALMDAADDLVRPLQDRPV 273 +G AGNA E + A + + G G D L +++ A D+ P ++PV Sbjct: 228 IGERAGNAAYEEVVMAVESVYGVDTGIDTTQITKLARIVEEASDIPVPA-NKPV 280 >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 60.8 bits (146), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 117/268 (43%), Gaps = 42/268 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG A++ S++ QIA AL+ VD +EV GF Sbjct: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEV-------------GFPV 49 Query: 64 HS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADV- 118 S D E ++ A +K++++ L D+ A++A A R+ T + + Sbjct: 50 SSPGDFESVQTIARQIKNSRVCGL---ARCVEKDIDAAYEALRVADAYRIHTFLATSPMH 106 Query: 119 ---------------SAQHIQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGATC 162 + + I+ AR D V F TP ++L + + GAT Sbjct: 107 IATKLRSTLPEVIERAVKMIRRARNY-TDDVEFSCEDGGRTPIDDLCRVVEAAINAGATT 165 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM---HAHHNLSLGVANSIAAVEEGCDR 219 I + D+ G + + F AL+A + P + H H +L + V N++AAV G + Sbjct: 166 INIPDTVGYTLPYEYANIFSALRARV-PNIDKAILSVHTHDDLGMAVGNALAAVNAGARQ 224 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKLG 247 I+ ++ G+G AGN LE I A G Sbjct: 225 IEGAMNGLGERAGNCALEETIMAIKTRG 252 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 60.5 bits (145), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 109/262 (41%), Gaps = 33/262 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N ++ I D TLRDG + +LE IA L VD IE + F Sbjct: 4 NPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAG-----------FPF 52 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVS 119 + D + + A V T+ + D+K ++A A R+ T +D+ Sbjct: 53 ASPGDFKAVNKIASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIH 112 Query: 120 AQH----------------IQYARELGMDTVGFLMM-SHMTTPENLAKQAKLMEGYGATC 162 +H + YA+ L +D + F + + P+ L + +L GAT Sbjct: 113 LKHKLKKSRKDVLQIVPEMVNYAKSL-VDDIEFSCEDASRSDPDFLYEVIQLAISAGATT 171 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G S+ + + + E +H H++L L VAN + AV+ G ++ Sbjct: 172 INIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQL 231 Query: 221 DASLAGMGAGAGNAPLEVFIAA 242 + ++ G+G AGNA LE + A Sbjct: 232 ECTINGIGERAGNASLEELVMA 253 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 60.5 bits (145), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 108/255 (42%), Gaps = 32/255 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K YI D TLRDG + +S ++AK +DDA + IE G A Sbjct: 3 EKKYIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEA-------------GIPA 49 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA--- 120 + E E ++++ K A + + D+ N++ ++ + + + + Sbjct: 50 MGNYEK-ETISEIMSQRKNALISTWNRMSRDDINNSFDCHPDIIHITAPISYIHIYSKLN 108 Query: 121 -----------QHIQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + A++ G + TVGF S + A L+ G + D+ Sbjct: 109 KNKKWLRNTLQECVFMAKDKGYEVTVGFEDASRADIT-FIISMANLLADMGVKSVRFADT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + R +K + + G+HAH++L + +ANS+ A + G ID ++ G+G Sbjct: 168 VGVLTPARTYQCIREIKENV--DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGGIG 225 Query: 229 AGAGNAPLEVFIAAA 243 AGN L FI AA Sbjct: 226 ERAGNCDLYQFILAA 240 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 60.5 bits (145), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 77/294 (26%), Positives = 119/294 (40%), Gaps = 57/294 (19%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K +YI D TLRDG ++ E +IA+ LD+ + IE GF Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEA-------------GFPI 68 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC------TEAD 117 S+ E AD+VK T+ G+ D+ +A + + A C T Sbjct: 69 VSERE-----ADIVK-----TIANEGLNA--DILALCRALKKDIDKAIECDVDGIITFIA 116 Query: 118 VSAQH--------------------IQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLME 156 S H ++YA+E G+ V F TP E+L K K E Sbjct: 117 TSPLHLKYKFNNKSLDEILEMGVEAVEYAKEHGL-FVAFSAEDATRTPIEDLIKVHKAAE 175 Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GA +++ D+ G + + LK LK + G+H H++ V NSI + G Sbjct: 176 EAGADRVHIADTTGCATPQSMEFICKTLKENLK-KAHIGVHCHNDFGFAVINSIYGLIGG 234 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 + ++ G+G AGNA LE I A L + DL ++ +L R +++ Sbjct: 235 AKAVSTTVNGIGERAGNAALEELIMA---LTVLYDVDLGLNLEVLPELCRMVEE 285 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 60.1 bits (144), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 74/336 (22%), Positives = 130/336 (38%), Gaps = 41/336 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++Y+ D TLRDG Q S +IAKAL+ VD IE + + Sbjct: 7 RVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAG-----------FPISSP 55 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D + + + V+ I L G I A Q R R+ T +D+ ++ Sbjct: 56 GDFQSVVEMSKAVQEPIICALTRANKGDIDSAVAALQYAKRP-RIHTGIGSSDMHIKYKF 114 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++YA++ D + + LA+ + + GAT + + D+ Sbjct: 115 NSTREKILERAVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPDT 174 Query: 169 GGAMNMSDIRDRFRALKAELKPETQT--GMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + LK +K Q +H H++L L AN++A + G +I+ ++ G Sbjct: 175 NGYCLPDQYGSKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTING 234 Query: 227 MGAGAGNAPLE---VFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRET 279 +G AGN LE + + LG + D ++ + R P+Q + + Sbjct: 235 IGERAGNTALEEVVMILKTHHALGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNA 294 Query: 280 LALGYAGVYSSFLRHCET----AAARYGLSAVDILV 311 A FL+H E G+++ DI++ Sbjct: 295 FAHSSGIHQDGFLKHRENYEIMNPEDVGINSADIIL 330 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 113/271 (41%), Gaps = 36/271 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLR+G ++++ +IAKAL D V IE H Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHP------------AVS 50 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR--VVRVATHCTEADVS--- 119 D+ E +VK K + +G +K + A V R+A +D+ Sbjct: 51 PDI--YEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVNRIAIFYGVSDLHLKA 108 Query: 120 -------------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 A+ I YA+ G+ T + L +K GA + + Sbjct: 109 KHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIA 168 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + S ++ F AL E+ P + +HAH++L L VAN++AA+E G I A++ G Sbjct: 169 DTVGILYPSKTKELFSALTREV-PNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNG 227 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 +G G PL+ AA + + G ++ L Sbjct: 228 LGERVGIVPLQQIAAA---IKYHFGIEVVKL 255 >UniRef50_Q0FWC0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FWC0_9RHOB Length = 337 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 9/114 (7%) Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 G +CIY+ D+ GA + +R A++ P+ +H H LG+AN++A +E G Sbjct: 201 GQPPSCIYLCDTIGAADPLQVRALVEAVRTRW-PDYPVALHLHDTRGLGIANAMAGLELG 259 Query: 217 CDRIDASLAGMG--------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD 262 R DAS+ G+G + AGN E D++G + G D+ AL+ A Sbjct: 260 VARFDASVGGLGGCPFAGNRSAAGNIATEELALLCDRMGIETGIDIPALLGVAQ 313 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 124/301 (41%), Gaps = 25/301 (8%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG ++E IA+ALDD VD IE G + G F A Sbjct: 2 LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEA--GTAIAGEE---EFRAVK 56 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------DVS 119 ++ A++ A+I + + + A + + + T ++S Sbjct: 57 EIANAGLKAEICSFARIKEIDIDAVANADADSVFMVAPSSDIHIKTKFPNKSGDDIIEMS 116 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQA-KLMEGYGATCIYVVDSGGAMNMSDIR 178 + ++YA+E G+ V F N K + + GA + D+ G + Sbjct: 117 VKAVEYAKERGL-IVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAE 175 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 R L +E H H++ L AN+I AV+ G I ++ G+G AGNAPLE Sbjct: 176 CIMRELTSEFN--VPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEE 233 Query: 239 FIAAADKL-GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY------AGVYSSF 291 + A + G + + D + LV L P+ +++ +GY +G+++S Sbjct: 234 VVLALETFYGIKTKIRKEKIYDTS-KLVEALTRFPIALNKPI--VGYNAFMHESGIHTSA 290 Query: 292 L 292 L Sbjct: 291 L 291 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 76/278 (27%), Positives = 118/278 (42%), Gaps = 47/278 (16%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +KL I D TLRDG A ++E ++AK L+ VD IE GF A Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEA-------------GFAA 58 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 S ++ EA +V K K +T+ D++ A +A A R H A S H+ Sbjct: 59 ASKGDF-EAVNEVAKEVKNSTVCSLARALHSDIERAGEALAPAERKRIHTFIA-TSPIHM 116 Query: 124 QY--------ARELGMDTVGFLMM-----------SHMTTPENLAKQAKLMEGYGATCIY 164 +Y E +D V F + + E L + + + GA I Sbjct: 117 EYKLRMTPEQVLERAVDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTIN 176 Query: 165 VVDSGG-------AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 V D+ G +SDI + + + +H H++L L VANS+ AV+ G Sbjct: 177 VPDTVGYAVPEEFGQLISDILNNVPNIDKAV-----ISVHCHNDLGLAVANSLTAVKNGA 231 Query: 218 DRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLY 255 ++ +++ G+G AGNA LE + A K+ + D+Y Sbjct: 232 GQVHSTINGIGERAGNAALEEVVMAI-KVRKDYFKDVY 268 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 58.5 bits (140), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 63/246 (25%), Positives = 103/246 (41%), Gaps = 34/246 (13%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG + +S+E I ALD A+V IE G A Sbjct: 9 IIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEA-------------GIPAMGKQ 55 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-IQYA 126 E E ++ + L+ + DLK + G + V V+ + D+ +H +Q + Sbjct: 56 E-CEDLKLMLNLPIKSNLIAWNRANLEDLKASIDCGFKFVHVSLPVS--DLHIEHKLQKS 112 Query: 127 RELGMDTVG----FLMMSHMTT-----------PENLAKQAKLMEGYGATCIYVVDSGGA 171 R +D + +L +T PE L + A + YGA I D+ G Sbjct: 113 RTWVLDQLKKCMEYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGC 172 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ + + + P + +HAH++ L VAN++AA + G ++ G+G A Sbjct: 173 LDHFTTYRKIKEIADHSPPPVE--IHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERA 230 Query: 232 GNAPLE 237 GNA +E Sbjct: 231 GNASME 236 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 58.5 bits (140), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 110/260 (42%), Gaps = 40/260 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ I D TLRDG + + +IA+ L VD +E + + Sbjct: 9 NQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAG-----------FPIAS 57 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIH--DLKNAWQA--GARVVRVATHCTEADVS 119 D E +E A V+ IA G+ IH D+ AW A A R+ T + +D+ Sbjct: 58 PGDFEAVETIARQVEGPVIA-----GLARIHVGDIDAAWNALRDASRPRIHTFVSTSDIH 112 Query: 120 AQH-IQYARE--LGM------------DTVGFLMM-SHMTTPENLAKQAKLMEGYGATCI 163 +H ++ RE +G+ D V F M + + E A+ ++ GAT I Sbjct: 113 IEHQMRSTREDVIGLTRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTI 172 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKP---ETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + D+ G M F EL P + +H H +L L VANS A V G ++ Sbjct: 173 NIPDTVG-YTMPHEYTAFLGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQV 231 Query: 221 DASLAGMGAGAGNAPLEVFI 240 + ++ G+G AGNA LE + Sbjct: 232 ECAINGLGERAGNASLEEIV 251 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 58.5 bits (140), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 111/256 (43%), Gaps = 38/256 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ + D TLRDG + + IAK L+ VD IE GF A Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEA-------------GFPA 48 Query: 64 HS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVS 119 S D ++ A +K+ + L G D+ AW+A V R+ +D+ Sbjct: 49 SSRGDFLAVQEIARTIKNCSVTGLARSVKG---DIDAAWEALKDGVSPRIHIFIATSDIH 105 Query: 120 AQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 +H ++YA+E + T LA+ + + GA+ I Sbjct: 106 LKHKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVI 165 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGM--HAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G + + + F+ +K + ++ + H H +L + VANS++A+E G D+I+ Sbjct: 166 NLPDTVGYLTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIE 225 Query: 222 ASLAGMGAGAGNAPLE 237 ++ G+G AGNA LE Sbjct: 226 CAINGIGERAGNAALE 241 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 58.5 bits (140), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 125/308 (40%), Gaps = 58/308 (18%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K++ D TLRDG +S+++ IA+ LDD +D IE G GS+ Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIE----GGWPGSN-------P 50 Query: 65 SDLEWIEAAADV-VKHAKIATLLLPGIGTIHDLKNAWQAGARV---VRVATHCTEADVSA 120 D ++ + ++ +KH+K L G+ KN + V V T + Sbjct: 51 KDKDFFARSGELNLKHSK-----LTAFGSTRFAKNPVEEDRNVKALVEAGTPVVSIFGKS 105 Query: 121 QHIQYARELGM----------DTVGFLMMSHMTTPENLAKQAKLMEGY------------ 158 + R LG+ DTVG++ H E + +GY Sbjct: 106 WDLHVRRALGISLEENLVLISDTVGYI---HGHGREVVYDAEHFFDGYTADPDYALRTLE 162 Query: 159 -----GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQ--TGMHAHHNLSLGVANSIA 211 GA+ + + D+ G + R + AE++ G+H H++ L VAN+IA Sbjct: 163 AAHKAGASVLCLCDTNGGT----VTGRLVEIVAEVRKRFDGIIGIHTHNDGDLAVANTIA 218 Query: 212 AVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD-KLGWQH-GTDLYALMDAADDLVRPLQ 269 AVE G + + G G GNA L IA + KLG G + A + + + L Sbjct: 219 AVEAGATHVQGCMNGYGERCGNANLASVIANLELKLGHTTVGPEKLAGLSSTCRFIAELA 278 Query: 270 DRPVRVDR 277 + P+R D+ Sbjct: 279 NLPLRNDQ 286 >UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides RepID=C3PVE7_9BACE Length = 528 Score = 58.2 bits (139), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 111/271 (40%), Gaps = 16/271 (5%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG + + + I K L+ A D IEV D + F+ E Sbjct: 3 DCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEVGFLDDRR--EFDINRSIMPSTEA 60 Query: 70 IEAAADVVKHAKIATLLLPGIGT-----IHDLKNAWQAGARVVRVATHCTEADVSAQHI- 123 I VK K + + GT I + + G RV+ +A + I Sbjct: 61 INKIFGSVKKGKAIPVAMIDFGTCSLDSIGSCDSTFIDGIRVIFKKEKIDQALPFCKAIK 120 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + +L + + S + E + + ++ + Y + +VD+ G ++ S + F Sbjct: 121 EKGYKLFIQAISITAYSDIEMLEYVNRINEI-KPYAFS---IVDTYGLLDNSSMARYFYL 176 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI---DASLAGMGAGAGNAPLEVFI 240 + L P + G H H+N LG +N+I +E+ R D+++ GMG AGN E+ Sbjct: 177 IDNNLDPSIKMGYHEHNNFQLGFSNTIKFLEKSTKRTLVADSTVYGMGKSAGNCASELLA 236 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 ++ H DL L++ D + P+ + Sbjct: 237 MHLNEYYGGH-YDLNQLLEIVDTDLMPIYQK 266 >UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B7ANX1_9BACE Length = 538 Score = 58.2 bits (139), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 62/280 (22%), Positives = 118/280 (42%), Gaps = 16/280 (5%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG I ++S + +R I++ L D+ +D +EV + F Sbjct: 2 KNISILDCTLRDGGRVINCEFSDDEIRDISRRLSDSNIDIVEVGFLRDSKKVHFEGNSTF 61 Query: 64 HSDLE----WIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV--VRVATHCTEAD 117 +D+ +++ ++ + + T+ G RV + + + D Sbjct: 62 FTDVNQIAPYLDKSSGNCMYVAFIDYGMFDFDTLGQCDGTSVDGIRVGFTKKDYYSSRDD 121 Query: 118 V-SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + +I AR + G +S+ + + + L+ +VD+ GAM D Sbjct: 122 IIRCLNIVKARGYKLFVQGVNSLSY--SDKEMLDLVDLVNEVHPYSFGIVDTYGAMYEDD 179 Query: 177 IRDRFRALKAELKPETQTGMHAHHN--LSLGVANSIAAVEEGCDRI--DASLAGMGAGAG 232 ++ + + + + H+H+N LS +A SI + + I DA+L GMG AG Sbjct: 180 LQRIYALINNNMHKDICIDFHSHNNYQLSFSLAQSIIRLSDSVRHIIIDATLNGMGKVAG 239 Query: 233 NAPLEVFI-AAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 N E+ + KL + D ++D DD + P +++ Sbjct: 240 NLNTELIVDYMVRKLNCNY--DFEQILDIIDDYIYPYKEK 277 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 58.2 bits (139), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 69/257 (26%), Positives = 110/257 (42%), Gaps = 32/257 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 +L I D TLRDG A + +IA+ L+ RVD+IE GF A Sbjct: 16 RLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEA-------------GFAAA 62 Query: 65 S--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV---VRVATHCT--EAD 117 S D E I A ++++ + +L G I A + R + +AT EA Sbjct: 63 SPGDSEAIRLIASEIRNSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREAK 122 Query: 118 VSAQHIQYAREL---------GMDTVGFLMMSHM-TTPENLAKQAKLMEGYGATCIYVVD 167 + + + + D + F + T P+ L + GA + V D Sbjct: 123 LRMSRREVLQTIERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVPD 182 Query: 168 SGGAMNMSDIRDRFRALKAEL-KPE-TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G +IR F L A + +P+ H H++L L V+NS+AAV+ G +++ ++ Sbjct: 183 TVGYSEPDEIRAVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAIN 242 Query: 226 GMGAGAGNAPLEVFIAA 242 G+G AGN LE + A Sbjct: 243 GIGERAGNCSLEEIVMA 259 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 57.8 bits (138), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 128/305 (41%), Gaps = 55/305 (18%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + + E ++A+ L+ D IE GF A Sbjct: 6 RVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEA-------------GFAAA 52 Query: 65 S--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 S D E + A A + + + +L D++ A +A A + H A S H Sbjct: 53 SPGDFEAVNAIAKTITKSTVCSL---SRAIERDIRQAGKAVAPAPKKRIHTFIA-TSPIH 108 Query: 123 IQY-------------------ARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGATC 162 ++Y ARE D V F + + + LA+ + GAT Sbjct: 109 MEYKLKMKPKQVIEAAVKAVKIAREY-TDDVEFSCEDALRSQIDFLAEICGAVIEAGATT 167 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTG------MHAHHNLSLGVANSIAAVEEG 216 I + D+ G + FR EL +T G H H++L L VANS+AA++ G Sbjct: 168 INIPDTVGYSIPYKTEEFFR----ELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGG 223 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRPLQDRP 272 +++ ++ G+G AGNA +E + A D G + G D ++ ++ LV + P Sbjct: 224 ARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSS-KLVSTITGYP 282 Query: 273 VRVDR 277 V+ ++ Sbjct: 283 VQPNK 287 >UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphaproteobacteria RepID=Q28KR2_JANSC Length = 319 Score = 57.4 bits (137), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 70/140 (50%), Gaps = 7/140 (5%) Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 E GM T + PE +A+ A+ + GA + + D+ G + +R RA++AE Sbjct: 146 EGGMATAFGCPFEGVVPPEQVARIARRYQDLGAKRVSLGDTTGMATPTTVRAAVRAIRAE 205 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG-----AGA-GNAPLEVFIA 241 P + +H H+ +G+A +A + EG DA++ G+G AGA GN E + Sbjct: 206 -APGVEICLHFHNTRGVGLACVMAGLAEGVSYFDAAIGGLGGCPFAAGATGNICTEDLVY 264 Query: 242 AADKLGWQHGTDLYALMDAA 261 ++ G++ G DL AL+ A Sbjct: 265 LLEESGYRTGVDLEALISVA 284 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 57.4 bits (137), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 109/260 (41%), Gaps = 45/260 (17%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+++ D TLRDG + S + +IA+ LD +D IE G G++ Sbjct: 4 KIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIE----GGWPGAN-------P 52 Query: 65 SDLEWIEAAADV-VKHAKIATLLLPGIGTIH----------DLKNAWQAGARVVRV-ATH 112 + E+ A V +++AK+A G+ H L +GARV V Sbjct: 53 VETEFFNAMRGVGLRNAKLA-----AFGSTHHPSHTPETDPTLTALISSGARVAAVFGKS 107 Query: 113 CTEADVSAQHIQYARELGM--DTVGFL---MMSHMTTPENLAKQAKLMEGY--------- 158 C A I R L + +++ FL M E+ K + Y Sbjct: 108 CPRHVEVALGISRERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALAVLRTAW 167 Query: 159 --GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GA C+ + D+ G +I R ++ L P G+HAH++ L VANS+AAV G Sbjct: 168 EHGADCLVLCDTNGGTMPEEISSIIRTVRERL-PHALLGIHAHNDCELAVANSLAAVNSG 226 Query: 217 CDRIDASLAGMGAGAGNAPL 236 ++ ++ G+G GNA L Sbjct: 227 AIQVQGTVNGIGERCGNANL 246 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 57.4 bits (137), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 112/286 (39%), Gaps = 47/286 (16%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG +SL++ I + LD+ VD +E Y Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGG-----------YPLSN 50 Query: 64 HSDLEWIEAAADV-VKHAKIATLLL---PGIGTIHD--LKNAWQAGARVVRVA-----TH 112 D E+ D+ +KH K+ + GI D ++ +GA VV + H Sbjct: 51 EKDAEYFRRVQDLNLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFH 110 Query: 113 CTE-------------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG 159 T+ AD A + RE+ D F PE A+ + G Sbjct: 111 VTDVLRVTLEENLAMIADSVAYIVGAGREVIYDAEHFFD-GWKANPEYAAETIRAAAKAG 169 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKP-ETQTGMHAHHNLSLGVANSIAAVEEGCD 218 A + + D+ G +I + A L G+H H++ L VANS+AAV+ G Sbjct: 170 ARMVVMCDTNGGSLPEEIAEYAAKAIAALTEFNVPVGIHTHNDGDLAVANSLAAVDAGAV 229 Query: 219 RIDASLAGMGAGAGNAPLEVFIA----------AADKLGWQHGTDL 254 ++ ++ G G GNA L IA G+QH T+L Sbjct: 230 QVQGTINGFGERCGNADLISVIANLGLKRKGYEVIGGAGYQHLTEL 275 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 57.0 bits (136), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 102/261 (39%), Gaps = 47/261 (18%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 L ISD TLRDG +S+ + IA+AL+ A VD IE + G Sbjct: 8 SPLIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEA-----------GFPAGG 56 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA-----------GARVVRVATH 112 ++E + A I L D+ AWQA G + H Sbjct: 57 AGEIEAVRQVAAATARPLIMALCR---AVDADVDAAWQALGDAPAERRGVGVFLATSPLH 113 Query: 113 ------CTEAD---VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY----- 158 T+A + A + YAR+ F ++ + + A L E Y Sbjct: 114 RRHKLGKTKAQCLAMIASSVAYARQR------FARVTFGCEDGSRTEPAFLREAYTAAMD 167 Query: 159 -GATCIYVVDSGGAMNMSDIRDRFRALKAELKPE-TQTGMHAHHNLSLGVANSIAAVEEG 216 GAT I D+ G + R R L +P + H H++L L AN++AA+ G Sbjct: 168 AGATAIGFPDTVGVLTPETARRRIAMLVRLAQPRGVKVRAHFHNDLGLATANTLAAIAAG 227 Query: 217 CDRIDASLAGMGAGAGNAPLE 237 D + ++ G+G AGNA LE Sbjct: 228 ADIVHLTVGGIGERAGNAALE 248 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 57.0 bits (136), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 99/240 (41%), Gaps = 4/240 (1%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I D TLRDG ++E IA+ LD VD+IE G + Sbjct: 14 ENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRRIV 73 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA-DVSAQH 122 LE V I + G+ IH R ++ E D + Sbjct: 74 ELGLEANICGLARVLREDIDAAIDCGVDYIHTFIGTSPL-HREYKLKMSPDEIIDRAVFG 132 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 ++YA E G+ + T + L + + E GA I V D+ G M + Sbjct: 133 VEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAMNHLVS 192 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 LK EL+ +H H++ L VANS+AAVE G ++ A++ G+G AGNA LE + A Sbjct: 193 RLKEELR--VPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALEEVVMA 250 >UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CL40_9FIRM Length = 528 Score = 57.0 bits (136), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 76/332 (22%), Positives = 135/332 (40%), Gaps = 65/332 (19%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG + ++ + + Q + L + VD +E+ GF + D + Sbjct: 8 DCTLRDGGYLNDWEFGYKMICQTVRQLIASNVDYVEL-------------GFLRNEDYQ- 53 Query: 70 IEAAADVVKHAKIATLLLPGIG-----TIHDLKNAWQA-------GARVVRVATHCTEAD 117 V +H K A +LP T+ L N + G + R+ + D Sbjct: 54 --PDRTVFRHVKDAYHILPKDCKNTRFTLMSLHNKYDISQLEDYDGGPIQRIRVTFHDYD 111 Query: 118 VSAQHIQYAR-------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 V + ++Y R E+ + + + S E L K ++ T +VD+ G Sbjct: 112 VE-EGLEYCRKVMEKGYEVACNPINIMGYSDGELLEILRKVNEI----HPTVFSIVDTFG 166 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVA-----NSIAAVEEGCDRIDASLA 225 +M +D+ + + L + G+H H NLSL + +I + C ID SL Sbjct: 167 SMKRNDLIRLYSLCENNLSKDITIGLHLHENLSLSYSLAQEFLNIKSYSRNC-VIDGSLL 225 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYA 285 GMG GN +E+ + + + ++ ++DA DD + P++ R++ GY+ Sbjct: 226 GMGRVPGNLCIELILDYLNN-NYAKTYNIDPILDAIDDYIVPIK----RLE----PWGYS 276 Query: 286 GVYSSFLRHCETAAARYGL--SAVDILVELGK 315 YS +A+Y L + + L+ GK Sbjct: 277 TAYS--------LSAKYNLHRNYAEFLLNKGK 300 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 113/278 (40%), Gaps = 51/278 (18%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV---AHGDGLQGSSFNYGFG 62 + I D TLRDG +SLE + IA+ LDD V +E A G Q S Sbjct: 9 IIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECGIPAMGREEQRS------- 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 ++A D+ HA++ T + D++ + Q G V ++ VS H Sbjct: 62 -------VKALVDLGLHARLITW---NRALVDDIRASLQCGVNAVDISL-----SVSDLH 106 Query: 123 IQ--------YARELGMDTVGFLMMSHMTTP-----------ENLAKQAKLMEGYGATCI 163 I+ + RE +GF + + L + +L GA Sbjct: 107 IRHKLRKDRHWVREQLKRALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRF 166 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G ++ ++ R L + + + +H H++L + AN+IA V G I+ + Sbjct: 167 RFCDTLGLLDPFVTFEKIRYLTQRVDLDIE--VHTHNDLGMATANAIAGVRAGARFINTT 224 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA 261 + G+G AGNA LE + +G +H + +D + Sbjct: 225 VNGLGERAGNAALEEVV-----MGLKHACGVKCPIDTS 257 >UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ Length = 355 Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 65/282 (23%), Positives = 115/282 (40%), Gaps = 47/282 (16%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDG-----------LQGSS 56 I D TLR+G+ A +++E ++AK + +A VD V+H ++ + Sbjct: 2 IIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESEVEVTRIIVERNY 61 Query: 57 FNYGFGA----HSDLEWIEAA-ADVVKHAKIATLLL-PGIGTIHDLKNAWQAGARVVRVA 110 F Y FG D++ I + A++ + L+ + I N + G ++ V Sbjct: 62 FKYVFGLGRALKEDIDLIASTGANISTYIPFEPQLVNKSLDVIKYAVNTYGKGKLIIEVG 121 Query: 111 -THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 T+ T ++S N+ K AK +E G I + DS Sbjct: 122 ITNITAYELS---------------------------NIVKLAKTLEELGVDRIQLADSL 154 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + + +K +K +H H+++ VANSI++V G D +DA++ G+G Sbjct: 155 GKATPKLMYNIVNNVKHTVK--IPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGE 212 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 G A L ++ D L DA + L + + D+ Sbjct: 213 RNGIADLATIAMILRNDSYRINIDFEKLRDAYNYLAKLIIDK 254 >UniRef50_Q21QR6 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Proteobacteria RepID=Q21QR6_RHOFD Length = 308 Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 127/304 (41%), Gaps = 54/304 (17%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 ++I+DV RDG+ + S N ++ +AL DA V S+E F + Sbjct: 4 IFITDVAPRDGLQSQAVTVSTSNKLRLIRALADAGVRSVEATS------------FVSPK 51 Query: 66 DLEWIEAAADVVKHAKI--------ATLLLPGIGTIHDLKNAWQAGARVVRVATHCT--- 114 + + AA+V+ + + L+P I L+ A GAR + V T Sbjct: 52 AVPQMADAAEVIAGLRFLESETGLRTSALVP---NIKGLERATAVGAREIAVVISATKTM 108 Query: 115 ----------EADVSAQ-HIQYARELGMDTVGFLMMS------HMTTPENLAKQAKLMEG 157 EA+ + + + AR G+ T ++ ++ +T P+ + + A M Sbjct: 109 NLKNINMNLAEAEENCKATLHAARASGLATRAYIAVAWECPFEGVTDPDTVVRLAAAMRV 168 Query: 158 YGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 GA I + D+ GA + R L A+ P +H H +G AN+ AA+E G Sbjct: 169 AGAGEIVIADTIGAAAPGQVAALLRVL-AQSIPLDMLAVHFHDTRGMGAANAYAALEAGV 227 Query: 218 DRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD----DLVRP 267 R DAS+ G+G AGN E + A + G+ G +L L+ A D L RP Sbjct: 228 RRFDASVGGIGGCPFAPGAAGNLATEDLVMLAHQCGFTTGINLDVLLLAVDMSEAFLGRP 287 Query: 268 LQDR 271 L R Sbjct: 288 LGGR 291 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 56.2 bits (134), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 61/260 (23%), Positives = 113/260 (43%), Gaps = 25/260 (9%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D TLR+GM A ++L+ +IA+++ + G++ + +Y S++ Sbjct: 2 LTDDTLREGMQAPGIAFTLDEKIRIAQSISKS-----------GIKRALVSYPSAHESEV 50 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI---- 123 E D+ H T L G D+ + G++V H D I Sbjct: 51 EAARKITDL--HLFDDTYSL-GRSIKEDVDSIISTGSKV---TLHLPFGDYDINKICDVV 104 Query: 124 QYARELGMDTVGFLMMSHMT-TPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 +YA + D+V ++ + E + AK + GA+ + + D+ G + D Sbjct: 105 KYASDHS-DSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVS 163 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K LK + + +H H++ L +ANSIA +E GCD +D ++ G+G G A + Sbjct: 164 YIKQNLKVKVE--VHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIADTASIASY 221 Query: 243 ADKLGWQHGTDLYALMDAAD 262 +K G++ + L D Sbjct: 222 LEKAGYEDKINFEMLRKTYD 241 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 56.2 bits (134), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 101/260 (38%), Gaps = 29/260 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +L + D TLRDG + ++AK L VD IE QG Sbjct: 3 MTANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQG------ 56 Query: 61 FGAHSDLEWIEAAADVVKHAKIATL--LLPG--------------IGTIHDLKNAWQAGA 104 D E + A VK KI L LP IH Q Sbjct: 57 -----DFESVSEIAAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHR 111 Query: 105 RVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 R ++ + ++ A+ D + T PE LAK + + GAT + Sbjct: 112 RFKLAKDEEEIVRIAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVN 171 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + R L ++ + +H H++L L V+NS+AA++ G +++ Sbjct: 172 IPDTVGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEG 231 Query: 223 SLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGNA LE I A Sbjct: 232 TINGIGERAGNAALEEIIMA 251 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 112/256 (43%), Gaps = 38/256 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ D TLRDG + + + IAK L+ V+ IE GF A Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEA-------------GFPA 48 Query: 64 HS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVS 119 S D ++ A +K+ +A L G D+ AW+A V R+ +D+ Sbjct: 49 SSRGDFLGVQEIARTIKNCSVAGLARCVKG---DIDAAWEALKDGVEPRLHVFIATSDIH 105 Query: 120 AQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 +H ++YA+E + T + LA+ + + GA+ I Sbjct: 106 LKHKLKKTREEVVEQAVAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVI 165 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGM--HAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G + + + F+ +K + + + H H +L + VANS+AA+E G D+I+ Sbjct: 166 NLPDTVGYLAPKEYGNIFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIE 225 Query: 222 ASLAGMGAGAGNAPLE 237 ++ G+G AGNA LE Sbjct: 226 TAVNGIGERAGNAALE 241 >UniRef50_Q120B4 Hydroxymethylglutaryl-CoA lyase n=7 Tax=Bacteria RepID=Q120B4_POLSJ Length = 317 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/115 (32%), Positives = 58/115 (50%), Gaps = 11/115 (9%) Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 G +Y+ D+ G N +I+ R A++ E+ P+ G+H H +G AN AA++ G Sbjct: 178 GVALPAVYLADTMGWANPEEIKRRIGAVR-EIVPDASIGLHLHDTRGVGGANIYAALQMG 236 Query: 217 CDRIDASLAGM----------GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA 261 D+S+AG+ G AGN E + +LG + G DL AL++AA Sbjct: 237 VRLFDSSVAGLGGCPFAGHQHGGAAGNICTEDMVFMCQELGIETGIDLEALIEAA 291 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 66/270 (24%), Positives = 113/270 (41%), Gaps = 31/270 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I+D TLRDG A ++LE IAK LD V +EV G A Sbjct: 3 KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEV-------------GIPAM 49 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ-HI 123 + E + A + A LL I D+K + G V +A + ++A+ H Sbjct: 50 GEEE-MRAICAISNLGLKANLLAWNRAVISDIKASVACGMERVHIAIPVSGIQIAAKFHG 108 Query: 124 QYARELG--MDTVGFLMMSHMTTP----------ENLAKQAKLM-EGYGATCIYVVDSGG 170 Q+ L D + F + + EN L + +GA+ D+ G Sbjct: 109 QWRVSLQRLKDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVG 168 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ + + L + L + +H H++ + AN++A ++ G ++ ++ G+G Sbjct: 169 VLDPFTTYGKVKLLVSALTIPVE--VHTHNDFGMATANALAGIKAGASSVNTTVIGLGER 226 Query: 231 AGNAPLEVFIAAADKL-GWQHGTDLYALMD 259 AGNA LE + A ++ G G D L++ Sbjct: 227 AGNAALEEVVMAIKRIYGVDMGIDTPRLLE 256 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 55.5 bits (132), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 30/252 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + +S + +IA+ LD V+ IE+ G A Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIEL-------------GIPAM 49 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA-------- 116 +E ++A + + A L + D++ + + + + ++ Sbjct: 50 GGIE-VDAISSIASLDLKARLTTWNRLHLSDIRASLSCRVKNLHICAPVSDIQIEYKLNK 108 Query: 117 ------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 D + I+YA++ G + PE L + A L + GA + D+ G Sbjct: 109 SRLWVLDCLKRAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVG 168 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + LK +LK E + H H++ L AN++AAV G ID ++ G+G Sbjct: 169 VLEPFSTYRELSWLKDKLKIELE--FHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGER 226 Query: 231 AGNAPLEVFIAA 242 AGNA +E +AA Sbjct: 227 AGNANMEEVVAA 238 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 55.5 bits (132), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/260 (22%), Positives = 113/260 (43%), Gaps = 31/260 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + + I D TLRDG A++ S++ QIA +L++ +D IEV + Sbjct: 1 MNSQ-VIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVG-----------FP 48 Query: 61 FGAHSDLEWIEAAADVVKHAKIATL-------LLPGIGTIHDLKNAWQAGARVVRVATHC 113 + D + ++ + +K+++I +L + +H NA++ + H Sbjct: 49 ISSPGDFKSVQTISKNIKNSRICSLARCLDKDIDAAAEAMHS-SNAFRIHIFLATSILHM 107 Query: 114 TEA---------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 D++ ++ A D + TT +NL + + + G I Sbjct: 108 ESKLKKNFDQIIDMAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G +++ L + ++ +H H++L + V NSI+A++ G +I+ Sbjct: 168 IPDTVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEG 227 Query: 223 SLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGN LE I A Sbjct: 228 TINGIGERAGNTALEEVIIA 247 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 68/269 (25%), Positives = 114/269 (42%), Gaps = 57/269 (21%) Query: 4 KKLYISDVTLRDGMHA----IRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 +K+ D TLRDG A ++H LE +A L+ A +++IE Sbjct: 6 RKITFLDTTLRDGEQAPGNSLKHGEKLE----LALMLEKAGIETIET------------- 48 Query: 60 GFGAHSDLEWI--EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-----VVRVAT- 111 GF A S ++I + + ++K + AT + D+ + QAG ++ VAT Sbjct: 49 GFPASSKEDFISTQKISKILKTSNFATF---SRTKLEDIDLSIQAGGTSEKHILMLVATG 105 Query: 112 ---HCTEA---------DVSAQHIQYARELGMDTVGFLM-------MSHMTTPENLAKQA 152 H + + + + YARE G+ V + ++ N+A Q+ Sbjct: 106 SDLHLEKKRKMSRQDGIEEIKKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQS 165 Query: 153 KLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAA 212 GA I + D+ G +DI D + K + + +H H++L L V NS A Sbjct: 166 ------GANQIILADTTGYAMPNDIYDLVKLSKRCISKSIKLSVHCHNDLGLAVINSYYA 219 Query: 213 VEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 + G D I ++ G+G AGN +E +A Sbjct: 220 ILAGADEIQGTIGGIGERAGNTSIEQVLA 248 >UniRef50_A7VV06 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV06_9CLOT Length = 520 Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 121/293 (41%), Gaps = 34/293 (11%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG---FGAHSD 66 D TLRDG + ++ + I + L D+ D +EV L+ S++ F ++ Sbjct: 7 DCTLRDGGYINDWKFGYRTAKSIIQKLVDSNADYVEVGF---LRNCSYDKNATLFNNIAE 63 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYA 126 L+ I K+ K + L I L+ VRV H + D + ++ Sbjct: 64 LKKILPREQ--KNTKFTVMALHNKYDITKLE-PNDGTVEAVRVTFHDYDIDEGLEFVKKV 120 Query: 127 RELGM----DTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 E G + + + S NL ++ ++ Y + +VD+ G+M SD+ + Sbjct: 121 MEKGYKCFCNPINIMGYSDQEIL-NLIQKINQIKPYAFS---IVDTFGSMIKSDLLRIYS 176 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANS-----IAAVEEGCDRIDASLAGMGAGAGNAPLE 237 L+ L G+H H NLSL + + + V C ID SL GMG GN LE Sbjct: 177 LLEHNLDKSIVIGLHLHENLSLSYSLAQEFIGMRNVNRDC-VIDGSLMGMGRVPGNLCLE 235 Query: 238 VFIAAADKL-GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYS 289 + + +K ++ D +++DA DD + + R+ GY YS Sbjct: 236 LIMDYMNKYDSVKYNVD--SVLDAIDDHILAI--------RKESPWGYTTEYS 278 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 115/269 (42%), Gaps = 48/269 (17%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +K+ + D TLRDG + ++ +IAK L VD IE G Sbjct: 1 MGDRKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEA-------------G 47 Query: 61 FGAHSDLEWIEAAADVVKH--AKIATLLLPGIGTI--HDLKNAWQA--GARVVRVATHCT 114 F A S+ + + VKH I +++ G+ D+ ++A A+ R+ Sbjct: 48 FPAASNGNF-----EAVKHIAENIDDVVVAGLSRCVKSDIDKTYEALKNAKKSRIHLFIA 102 Query: 115 EADVSAQHIQY--------ARELGMDTVGF-------LMMS----HMTTPENLAKQAKLM 155 +D+ H++Y A ++ +D+V + + S T + L K + Sbjct: 103 TSDI---HLKYKLKISRDEALKMAVDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEV 159 Query: 156 EGYGATCIYVVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAV 213 GA I + D+ G + +K + K +H H++L + V NS++A+ Sbjct: 160 VDAGAKIINIPDTVGYAVPKEFEKLVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSAL 219 Query: 214 EEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 E G D+++ ++ G+G AGNA LE I A Sbjct: 220 ENGADQVEVTVCGIGERAGNASLEEVIMA 248 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 77/272 (28%), Positives = 112/272 (41%), Gaps = 38/272 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + L + D TLRDG +SL + IA+ALD A V IEV G A Sbjct: 5 RTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEV-------------GIAA 51 Query: 64 HSDLEWIEAAA--DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 + W E A VV AT ++ +HDL A + G + V A + A + Sbjct: 52 ---MGWAEVAEIRAVVAEIAHATPVVWCRLRMHDLDMAQKTGVKRVHFAVPTSTAQLEGK 108 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 +A + A + G+ + T P+ L + A++ GA + D Sbjct: 109 LRVDRDWILRETAALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIAD 168 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTG--MHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + + + D FR L AEL MHAH++ + AN+I A G + ++ Sbjct: 169 T---LGLLDPLGAFR-LVAELSARISLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVN 224 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 G+G AGNA E AA + G G DL AL Sbjct: 225 GLGERAGNAACEEVGAALEAGGIDTGLDLCAL 256 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 55.1 bits (131), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 104/260 (40%), Gaps = 40/260 (15%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 NGK + I D TLRDG ++L+ IA LDD V+ IE G GS+ Sbjct: 7 NGKTIEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIE----GGWPGSN----- 57 Query: 62 GAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTI-----HDLKNAWQAGARV--------- 106 DLE+ + ++++KIA I ++LK + A V Sbjct: 58 --PKDLEFFKLIKKHELRNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSS 115 Query: 107 --VRVATHCTEAD---VSAQHIQYARELGMDTVGFLMMSHM-----TTPENLAKQAKLME 156 V +C+ D + + + RE G+ T + H PE + K E Sbjct: 116 FHVEKILNCSLEDNLEMIYDSLIFLRESGLQT--YFDAEHFFDGYNINPEYAIQTVKTAE 173 Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 I + D+ G M I + +K E + G H H++ VAN+++AV G Sbjct: 174 EAKVNTIVLCDTNGGMLPHQIERVVKKIKKN--SEVKIGFHGHNDTGCAVANTVSAVVAG 231 Query: 217 CDRIDASLAGMGAGAGNAPL 236 I ++ G+G GNA L Sbjct: 232 ATHIQGTINGLGERTGNADL 251 >UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU Length = 265 Score = 54.7 bits (130), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/258 (22%), Positives = 110/258 (42%), Gaps = 38/258 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I D TLRDG + +++E +IAK LD+ + IE G A Sbjct: 3 RNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIEC-------------GIPA 49 Query: 64 HSDLEW--IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA- 120 +E I+A K+A I+T I D+K + ++ ++ ++ + Sbjct: 50 MGCMEQEIIKAIKANTKNALISTW---NRLNIDDIKASMNCKPHIIHISVPVSDLQIYEN 106 Query: 121 -------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I Y +E G D L + + + + + L+E G I D Sbjct: 107 LNKDKKWIEENLIKCIYYTKEQGYDVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYSD 166 Query: 168 SGGAMNMSDIRDRFRALK--AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G +++ ++ ++ + LK E +HAH++ + + S+ AV+ G + +D +L Sbjct: 167 TVGILSLLKTKNVVNEIRRNSNLKVE----IHAHNDFGMALGISVEAVKNGAEFVDCTLD 222 Query: 226 GMGAGAGNAPLEVFIAAA 243 G+G GN L+ F+ + Sbjct: 223 GIGERTGNCSLQEFLKIS 240 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 54.7 bits (130), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 69/258 (26%), Positives = 107/258 (41%), Gaps = 32/258 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +L I DVTLRDG +S IAK L VD +E+A +G Sbjct: 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET----V 62 Query: 64 HSDLEWIEAAADVVKHAKIATL-LLPGIGTIHDLKNAWQAGARVVRVAT----HCTE--- 115 +EW E +I L + G T+ +K++ GARV+ + T H E Sbjct: 63 QKIIEWAETEQLT---ERIEILGFVDGNKTVDWIKDS---GARVLNLLTKGSLHHLEKQL 116 Query: 116 --------ADVSAQHIQYARELGMDTVGFL---MMSHMTTPENLAKQAKLMEGYGATCIY 164 ADVS I+YA + G+ +L +P+ + K + I+ Sbjct: 117 NKTPKEFFADVSIV-IEYAIKNGLKINVYLEDWSNGFRNSPDYVEALVKHLSKERIERIF 175 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ G ++ + +L + P H H++ L VANS+ A+ G + AS+ Sbjct: 176 LPDTLGVLSPEETFQGVDSL-VQKYPNLHFEFHGHNDYDLSVANSLQAIRAGVKGLHASM 234 Query: 225 AGMGAGAGNAPLEVFIAA 242 G+G AGN PLE + Sbjct: 235 NGLGERAGNTPLEALVTT 252 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 54.7 bits (130), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 66/281 (23%), Positives = 115/281 (40%), Gaps = 32/281 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I+D TLRDG A + + IA LD V IEV G Sbjct: 1 MN-SSITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEV-------------G 46 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A +E EA ++ A LL D+ + + G + + ++ ++ ++A Sbjct: 47 IPAMGAVE-TEAIRAMLSLGLRAHLLGWNRAVPSDILASIRCGLKRIHISVPVSDRQIAA 105 Query: 121 --------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 Q ++ A E G+ + T+ E + + A++ + +G Sbjct: 106 KFQGDRPRLLRQLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYC 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + R L + + MH H +L + AN++A + G ++ ++ G Sbjct: 166 DTVGVLDPFSTYKQIRRLVRAI--DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNG 223 Query: 227 MGAGAGNAPL-EVFIAAADKLGWQHGTDLYALMDAADDLVR 266 +G AGNAPL EV +A LG G D L + + + R Sbjct: 224 LGERAGNAPLEEVVMALRCTLGIDVGVDTRRLRELSQQVAR 264 >UniRef50_Q0QFQ4 Putative uncharacterized protein hbzL n=1 Tax=Pseudomonas alcaligenes RepID=Q0QFQ4_PSEAC Length = 225 Score = 54.7 bits (130), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 7/119 (5%) Query: 152 AKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIA 211 A+ +E G+ + + D+ G + S + +A + P T+ +H H+ +G+AN +A Sbjct: 63 ARYIEAMGSNGVTLCDTTGMAHPSQVFALTQAFRKRW-PATELTLHFHNTRGMGLANVLA 121 Query: 212 AVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 A++ G D+ D SL G+G +GN E A + +G++ G DL LM AA L Sbjct: 122 AIDAGADQFDVSLGGIGGCPYAPGASGNICSEEIAHALECMGYETGIDLVRLMAAAHRL 180 >UniRef50_A9IXU0 Putative uncharacterized protein n=1 Tax=Bartonella tribocorum CIP 105476 RepID=A9IXU0_BART1 Length = 119 Score = 54.7 bits (130), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 7/79 (8%) Query: 160 ATCIY-----VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVE 214 A CI+ V S G++ + D + + P + G HAH NL + +ANSIAAVE Sbjct: 6 AFCIWPILMEVFYSNGSL-LPDTVTQLVQKTKSITP-LEIGFHAHDNLGIAMANSIAAVE 63 Query: 215 EGCDRIDASLAGMGAGAGN 233 G ID SL GMG GAGN Sbjct: 64 AGASFIDGSLMGMGKGAGN 82 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 54.7 bits (130), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 70/264 (26%), Positives = 112/264 (42%), Gaps = 43/264 (16%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH------------ 48 + ++ I D TLRDG + S +A+ALD+ VD IE Sbjct: 7 ITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMA 66 Query: 49 --GDGLQGSSFNYGFGA---HSDLEW----IEAAADVVKHAKIATLLLPGIGTIHDLKNA 99 G L+ S + + +D+E +EAAA+ H ++T L H L+ Sbjct: 67 LIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPL---HREHKLRMT 123 Query: 100 WQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGY 158 + VR +H+ AR +D V F T + L + ++ Sbjct: 124 REQVLESVR------------KHVSLARSY-IDDVEFSAEDATRTELDYLIEVSRAAISA 170 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQT---GMHAHHNLSLGVANSIAAV 213 GAT I + D+ G +IR+ F+ + A + P H H++L L VANS+AA+ Sbjct: 171 GATTINLPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAI 230 Query: 214 EEGCDRIDASLAGMGAGAGNAPLE 237 E G +++ ++ G+G AGN LE Sbjct: 231 EGGARQVECTVNGIGERAGNCSLE 254 >UniRef50_Q0RGT1 Putative aldolase n=1 Tax=Frankia alni ACN14a RepID=Q0RGT1_FRAAA Length = 240 Score = 54.3 bits (129), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 47/142 (33%), Positives = 66/142 (46%), Gaps = 3/142 (2%) Query: 103 GARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 G +VRV + + ++ AR+ G+ T L + P LA GA Sbjct: 19 GVGLVRVLAPGLDLVPALPYLAAARDAGLLTAVNLTHTSRADPARLALAVSRAAQAGAGL 78 Query: 163 IYVVDSGGAMNMSDIRDRFRAL---KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 +Y+ DS G++ D+ R A E P G HAH NL L ANS AA++ G Sbjct: 79 VYLADSNGSLYPEDVTRRVSAAVHAATEQGPGPVIGFHAHDNLGLAFANSCAALDAGATA 138 Query: 220 IDASLAGMGAGAGNAPLEVFIA 241 +DAS+ G+G G GN LE+ A Sbjct: 139 LDASIGGIGKGGGNLRLELIAA 160 >UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Tax=cellular organisms RepID=B4U857_HYDS0 Length = 619 Score = 54.3 bits (129), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 31/292 (10%) Query: 4 KKLYISDVTLRDGMHA-IRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +KLY +DV+LRDG+ + + + E++ + LD S+EV G++F+ Sbjct: 2 EKLYFTDVSLRDGIQSLLATRVRTEDMLPALEILDKCGFWSLEVWG-----GATFDVCLR 56 Query: 63 AHSDLEW--IEAAADVVKHAKIATLL----LPGIGTIHD------LKNAWQAGARVVRVA 110 + W ++ ++ K+ K+ LL + G D +K ++ G V R+ Sbjct: 57 YLKEDPWERLKQFKNITKNTKLEMLLRGQNIVGYRNYPDDVVEAFVKKSYDNGVEVFRIF 116 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTP----ENLAKQAKLMEGYGATCIYVV 166 + + I+ + L G L S+ T+P E K AK + G I + Sbjct: 117 DALNDVRNMRKAIETGKSLNAIVKGVL--SYTTSPVHTVEYYVKIAKDLVNMGIDIISIK 174 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVAN--SIAAVEEGCDRIDASL 224 D G + D +ALK E K +H H + +AN + A+E G D + Sbjct: 175 DQSGILTPKMAFDLVKALKQEFK----LPIHIHTQTTAELANMSQLKALEAGATMFDTAF 230 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD 276 + + + E I + G+Q D AL + A ++ R ++ + + D Sbjct: 231 YSLSSQTSHPSGETMIHVFKEFGYQIDVD-QALYEEAGNVFREVRKKYKKYD 281 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 54.3 bits (129), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 116/267 (43%), Gaps = 54/267 (20%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG + + E +IA+ L+ RVD IE GF A S Sbjct: 5 LIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEA-------------GFPAAS 51 Query: 66 --DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADV--- 118 D E ++A A +K + I L G D++ A +A GA R+ T + + Sbjct: 52 NGDFEAVKAVAAAIKGSTICGLARAIEG---DIRRAGEALRGANSARIHTFIATSPIHME 108 Query: 119 -------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQ-----AKLMEGY-- 158 + + +++AR+ D V F +PE+ + +++E Sbjct: 109 KKLRMSPDQVVEQAVKAVKFARQY-TDDVEF-------SPEDAGRSDITFLCRVLEAVID 160 Query: 159 -GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQT--GMHAHHNLSLGVANSIAAVEE 215 GA + + D+ G + R L+ + + +H H++L L VANS++AV Sbjct: 161 AGAGTVNIPDTVGYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMN 220 Query: 216 GCDRIDASLAGMGAGAGNAPLEVFIAA 242 G +++ ++ G+G AGNA LE + A Sbjct: 221 GARQVECTVNGLGERAGNASLEEVVMA 247 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 53.9 bits (128), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 102/250 (40%), Gaps = 37/250 (14%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH------------------GDG 51 D TLR+G +S++ +IA+AL DA V IE H G Sbjct: 6 DSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETVLKSIKSIMELKSSG 65 Query: 52 LQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATL-LLPGIGTIHDLKNAWQAGARVVRVA 110 + S+ AHS + + DV I + + GI +H + +R+ Sbjct: 66 IIRSTI----VAHS--RAVRSDIDVAASLNIDMIAIFYGISDLHLKYKTLKTREDAIRII 119 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPEN-LAKQAKLMEGYGATCIYVVDSG 169 I YAR G++ V F T N L A+ GA I + D+ Sbjct: 120 VDS---------IDYARSYGLN-VRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTV 169 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G +N F+ + ++K + +HAH++L + VANSIAA G I +++ G+G Sbjct: 170 GILNPDTSYKLFKMIIKDVK-NVEFDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGE 228 Query: 230 GAGNAPLEVF 239 +G P ++ Sbjct: 229 RSGITPTQII 238 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 53.9 bits (128), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 113/250 (45%), Gaps = 26/250 (10%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIE-----VAHGDGLQGSSFNY 59 ++ I D TLRDG A +++ +IA+ LD+ V+ IE V+ G+ + + Sbjct: 18 EIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGER-KAAREMV 76 Query: 60 GFGAHSDL----EWIEAAADVVKHAKIATL-LLPGIGTIHDLKNAWQAGARVVRVATHCT 114 G S+L ++ D + + ++ L G +H R ++ T Sbjct: 77 SLGFSSELCGLARVVQKDIDALIDSDLSYAHLFIGTSPLH----------RDYKLKKSKT 126 Query: 115 EA-DVSAQHIQYARELGMDTVGFLMMSHMTTPEN-LAKQAKLMEGYGATCIYVVDSGGAM 172 E S + ++YA++ G+ V F T N L + K +E GA I V D+ G + Sbjct: 127 EILSQSMEMVEYAKDHGLK-VEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGIL 185 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 S R R L+ ++ +H H++ L V+NS+ +EEG ++ ++ G+G AG Sbjct: 186 VPSTTRTLIRTLRKKIN--LPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAG 243 Query: 233 NAPLEVFIAA 242 N LE + + Sbjct: 244 NTSLEELVVS 253 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 53.5 bits (127), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 113/274 (41%), Gaps = 63/274 (22%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS-- 65 I D TLRDG + + + IA+ L VD IE GF A S Sbjct: 89 IFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEA-------------GFPAASKD 135 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTI-----HDLKNAWQA--GARVVRVATHCTEADV 118 D E ++ A+ V + +P I + D++ AW+A A+ R+ T +D+ Sbjct: 136 DFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDI 195 Query: 119 SAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAK--LME---- 156 ++ +++AR LG + V F +PE+ + + L E Sbjct: 196 HLKYKLKKSKEEVIEIARNMVRFARSLGCEDVEF-------SPEDAGRSEREYLYEILGE 248 Query: 157 --GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQ------TGMHAHHNLSLGVAN 208 GAT + + D+ G S+ F L A++K T H ++L L AN Sbjct: 249 VIKAGATTLNIPDTVGITLPSE----FGQLIADIKANTPGIQNVIISTHCQNDLGLSTAN 304 Query: 209 SIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +++ G +++ ++ G+G AGNA LE + A Sbjct: 305 TLSGAHSGARQVEVTINGIGERAGNASLEEVVMA 338 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 62/263 (23%), Positives = 109/263 (41%), Gaps = 51/263 (19%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG A + E ++A L++ VD IE GF A Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIET-------------GFPA 48 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-----VVRVATHC----- 113 S ++ EA + K + + D++ + ++G R + VAT Sbjct: 49 SSKFDY-EATKLISKEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLK 107 Query: 114 TEADVSAQH--------IQYARE-------LGMDTVG---FLMMSHMTTPENLAKQAKLM 155 + ++S +++A++ +G++ F M +T A Sbjct: 108 NKRNISRSQAIEEVINTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFA------ 161 Query: 156 EGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEE 215 GA I + D+ G S+ + + ++++ H H++L L AN++A +E Sbjct: 162 ---GAHQIILADTTGYATPSEFKKLIQFIRSKTGDGISISTHCHNDLGLAHANTLAGIEG 218 Query: 216 GCDRIDASLAGMGAGAGNAPLEV 238 G D + +L G+G AGNA LE+ Sbjct: 219 GADEVQVTLGGIGERAGNASLEM 241 >UniRef50_D1VPY0 Putative uncharacterized protein n=1 Tax=Frankia sp. EuI1c RepID=D1VPY0_9ACTO Length = 80 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/59 (54%), Positives = 38/59 (64%), Gaps = 3/59 (5%) Query: 278 ETLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 ETL LGYA VYS+FLR+ ETAA R+GL ILV+ RR+V E V L LR+N Sbjct: 6 ETLTLGYAEVYSAFLRYAETAAHRHGLDTRSILVD---RRLVECAELSQVQAKLGLRDN 61 >UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E183 Length = 345 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 96/227 (42%), Gaps = 19/227 (8%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D TLR+GM S + ++AK + A + VA+ AH Sbjct: 2 LTDDTLREGMQTPGFAMSYDEKIELAKLISSAGIKRALVAYPP------------AHK-- 47 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV-VRVATHCTEADVSAQHIQYA 126 E A +V + G D+ + GA + + + ++I+YA Sbjct: 48 SEFEVTAAIVDGKYFQQVFGLGRTVKEDIDMINETGANISLHLPFKLDNMGQVYENIKYA 107 Query: 127 RELG-MDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 LG + +GF+ + M + E + K ME + + D+ G MN + I++ F A K Sbjct: 108 CTLGKIVEIGFVDID-MFSVEQITKFCHKMEELNVDVVQLPDTRGKMNPAAIKNVFEAAK 166 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + H H++ + VAN+I+A+ G D ID ++ G G G Sbjct: 167 KATNIKIEA--HCHNDYGMAVANTISAISAGVDYIDTTIFGTGERNG 211 >UniRef50_D1PP40 Putative uncharacterized protein n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PP40_9FIRM Length = 519 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 55/108 (50%), Gaps = 4/108 (3%) Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---ID 221 +VD+ G+M D+ L P+ + G+H H N++L + +++ R +D Sbjct: 164 IVDTFGSMRRRDLERIVSLADHNLAPDIRLGLHLHENMALSFCLAQEFIDKPLLRDKTVD 223 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ 269 ASL GMG GN P+E+ ++ G H DL +MDA D + P++ Sbjct: 224 ASLMGMGRAPGNLPIELVADYRNETGSCH-YDLDEIMDAIQDHIAPIK 270 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 108/266 (40%), Gaps = 48/266 (18%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + + QIA+ L VD IE + + Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAG-----------FPITS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSAQ 121 D E + A VK +A L + D++ AW A A R+ T +D+ Sbjct: 51 PGDKEAVSLIAREVKGVVVAAL---ARASALDIETAWDAIKDAESPRIHTFIATSDI--- 104 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQ--------------------AKLMEGY--- 158 H++Y ++ +TV + LAK+ +++E Sbjct: 105 HLKYKLKMDRETV----VERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKA 160 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRAL--KAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GAT I + D+ G + + + K + +H H +L L VANS+AA++ G Sbjct: 161 GATTINIPDTVGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNG 220 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAA 242 +++ ++ G+G AGN LE + A Sbjct: 221 ARQVECTINGIGERAGNCSLEEIVMA 246 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 69/284 (24%), Positives = 116/284 (40%), Gaps = 50/284 (17%) Query: 10 DVTLRDGMH----AIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 D TLRDG A+ LE RQ+AK RVD +EV + + Sbjct: 89 DTTLRDGEQSPGAALTPPQKLEIARQLAKL----RVDIMEVG-----------FPVSSEE 133 Query: 66 DLEWIEAAADVV-KHAKIATLLLPGIGTI-----HDLKNAWQA--GARVVRVATHCTEAD 117 + E I+ A V T +P I I D++ W+A A+ RV + ++ Sbjct: 134 EFEAIKTIAKTVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSE 193 Query: 118 VSAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY--G 159 + ++ ++YA+ LG + F T ++ + L E G Sbjct: 194 IHMKYKLKKTKEEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKI-LGESIKAG 252 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKP---ETQTGMHAHHNLSLGVANSIAAVEEG 216 AT + D+ G +NM A E P + +H H++L + AN+I+ + G Sbjct: 253 ATTVGFADTVG-INMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAG 311 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDA 260 +++ ++ G+G +GNAPLE + A G +Y +D+ Sbjct: 312 ARQVEVTINGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDS 355 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 101/248 (40%), Gaps = 19/248 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+YI D TLRDG +SLE+ +IA+ LDD + IE G N F Sbjct: 3 EKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIE--GGWPYANPKDNLFFQK 60 Query: 64 HSDLEWIEAA-----------ADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 + + A V + ++ +L+ + +W T Sbjct: 61 AKKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTL 120 Query: 113 CTEADVSAQHIQYARELGMDTVGF----LMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ + ++Y + +D V F + + PE + + GA + + D+ Sbjct: 121 EENLNMIYETVEYLKRY-VDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDT 179 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G +I + + +K K + G+HAH++ VANS+ AV G ++ ++ G+G Sbjct: 180 NGGTLPHEIYEITKKVKERFK-DANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIG 238 Query: 229 AGAGNAPL 236 GNA L Sbjct: 239 ERTGNANL 246 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 105/260 (40%), Gaps = 46/260 (17%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K + D TLRDG +Y+ E +IA+ LD A ++SI+ GF A Sbjct: 16 KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDA-------------GFAAT 62 Query: 65 SDLEW--IEAAADVVKHAKIAT---------------------LLLPGIGTIHDLKNAWQ 101 S+ E I D+ +I + L +PG D+ + Sbjct: 63 SEEERLSIRKICDLGLKMRIMSMCRVIREDIDFASSCGVEGVILFIPG----SDIHLKAK 118 Query: 102 AGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPEN-LAKQAKLMEGYGA 160 G + V + + + A I+YA++ G+ V F + T N L + E GA Sbjct: 119 FGEDIPAVRKNIVQKAMDA--IKYAKDKGL-FVEFGVEDSTRTDFNVLLEILSQAEQEGA 175 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + D+ G + + + L LK G+H H+++ L AN+IA + G Sbjct: 176 DILGTTDTIGYLTPERTYNFIKKLVRNLK--LPIGVHCHNDMGLATANTIAGLLAGGGYC 233 Query: 221 DASLAGMGAGAGNAPLEVFI 240 ++ GMG AGNA LE I Sbjct: 234 SPTVNGMGERAGNASLEEVI 253 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 110/269 (40%), Gaps = 52/269 (19%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG A++ S++ QIA AL+ VD +EV GF Sbjct: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEV-------------GFP 48 Query: 63 AHS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 S D E ++ A +K++++ L I D+ A R+ T S Sbjct: 49 VSSPGDFESVQTIARTIKNSRVCALARCVEKDI-DVAAESLKVAEAFRIHTFIA---TSP 104 Query: 121 QHI-------------------QYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGA 160 HI + AR D V F TP +LA+ + GA Sbjct: 105 MHIATKLRSTLDEVIERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGA 163 Query: 161 TCIYVVDSGG-------AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAV 213 T I + D+ G A +S + DR + + +H H +L + V N++AAV Sbjct: 164 TTINIPDTVGYTMPFEYANIISGLYDRVPNIDKAI-----ISVHTHDDLGIAVGNALAAV 218 Query: 214 EEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 G +++ ++ G+G AGN LE I A Sbjct: 219 HAGARQVEGAMNGIGERAGNCALEEVIMA 247 >UniRef50_B0T0Z5 Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B0T0Z5_CAUSK Length = 301 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 57/112 (50%), Gaps = 7/112 (6%) Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 G I + D+ G + +R R A++A P+ + +H H + G+AN+ A VE G D Sbjct: 169 GVPEIAIADTIGVADPWTVRRRVEAVRAA-APDVRLRLHFHDTRNTGLANAYAGVEAGVD 227 Query: 219 RIDASLAGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 +DAS+ G+G GN E + ++ G++ G DL AL++ D+ Sbjct: 228 VLDASVGGLGGCPFAPNATGNIGTEDLVYMLERAGFETGYDLSALIEIGRDI 279 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 52.4 bits (124), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 66/253 (26%), Positives = 102/253 (40%), Gaps = 41/253 (16%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIE-----VAHGD--------- 50 K+ I D TLRDG +S+++ IA LD+ VD IE V+ D Sbjct: 31 KVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQDATAITEISK 90 Query: 51 -GLQGSSFNYGFGAHSDLEW-IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR 108 GL+ + + +D++ ++ AD G I ++ G ++ Sbjct: 91 LGLKSKIYTFARAMKADIDMALQCGAD---------------GVIIEV----PIGYPKLK 131 Query: 109 VATHCTEADV---SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAK-LMEGYGATCIY 164 T DV SA I YA+E G+ V F + +L K +M+ I Sbjct: 132 TQFGWTWEDVVKKSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIG 191 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 +VD+ G I+ R L E +H H++ +GVA +AAV G + + Sbjct: 192 LVDTMGCATPEAIKYMVRWLTK--MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCA 249 Query: 225 AGMGAGAGNAPLE 237 G+G GNA LE Sbjct: 250 NGLGERTGNAALE 262 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 52.4 bits (124), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 69/258 (26%), Positives = 114/258 (44%), Gaps = 28/258 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV-----AHGDGLQGSSFN 58 K+++I D TLRDG A S E IAK L D VD IE + GD + + Sbjct: 3 KRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPGDFMAVQRIS 62 Query: 59 Y--------GFGAHSDLEWIEAAADVVKHAKIATL-LLPGIGTIHDLKNAWQAGARVVRV 109 GF A + E I+AA + A+ L + +IH ++ +V+++ Sbjct: 63 QEVHGVEICGF-ARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQLRKSREQVIKI 121 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMM-SHMTTPENLAKQAKLMEGYGATCIYVVDS 168 A + I Y ++ +D F M + T E L + + GAT I + D+ Sbjct: 122 AR---------EMIAYGKQF-VDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPDT 171 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + F + ++ + + H H++L L VANS+AA+ G +++ ++ G Sbjct: 172 VGYALPEEYGAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVNG 231 Query: 227 MGAGAGNAPLEVFIAAAD 244 +G AGN LE + A + Sbjct: 232 VGERAGNCSLEELVMAIE 249 >UniRef50_C5AMG4 MhpE-like protein n=1 Tax=Burkholderia glumae BGR1 RepID=C5AMG4_BURGB Length = 305 Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 62/243 (25%), Positives = 103/243 (42%), Gaps = 11/243 (4%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + + D TLRDG + H +S + I L + VD IEV + Sbjct: 11 ARAVTLLDCTLRDGGYLNGHDFSAPQIDAILTRLLASGVDVIEVGYFRRRNVERHPSTVI 70 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 A ++ + A + + A ++ PG DL + VVR CT+ ++ Sbjct: 71 ARCPPAFLASLART-QAVRYAVMVPPGDAEPADLDELAELPVSVVRFT--CTDQNLPKVL 127 Query: 123 I--QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + A LG+ + + LA + + G +Y DS GA+ D Sbjct: 128 ALGERAARLGLVVCANITRVSERSHSQLAALTRALAEAGFDTVYAADSNGAL----YPDE 183 Query: 181 FRALKAELKPET--QTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 A+ E++ Q G HAH +L L AN++AA+ G +D ++ G+G G GNA +EV Sbjct: 184 VAAIVGEMRRHFTGQIGFHAHDSLHLAFANALAAMRAGASWVDGTIGGVGKGGGNAAIEV 243 Query: 239 FIA 241 ++ Sbjct: 244 LLS 246 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/249 (21%), Positives = 104/249 (41%), Gaps = 32/249 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++++ D TLRDG + + +A+ L +A V IE G A Sbjct: 3 QRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIET-------------GVPA 49 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 + E E A +VK + I DL+ + G R V + ++ ++ Q + Sbjct: 50 MGEDEQ-ETIARIVKLNLPTRVTTWNRAVISDLEASLNCGVRSVAICLPSSDQQIT-QKL 107 Query: 124 QYARELGMDTVGFLMM---------------SHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + +R+ +D +G + + P+ L + E + + D+ Sbjct: 108 RQSRQWVLDQMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ + F L + L + +HAH++L + AN+++A++ G ++ G+G Sbjct: 168 LGILDPIRTFNLFDRLTSSLSIPLE--IHAHNDLGMATANTVSAIQAGAKAASVTVCGLG 225 Query: 229 AGAGNAPLE 237 AGNAPLE Sbjct: 226 ERAGNAPLE 234 >UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8 Length = 381 Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 98/250 (39%), Gaps = 23/250 (9%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH----GDGLQGSSFNYGFGA 63 I D T+RDGM + SL +++ K ++ ++S+EV D F Sbjct: 4 IQDNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDEFNIHQFRDILSP 63 Query: 64 HSDL--------EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 +L + I+ + H + +LLP I +H + + ++ C + Sbjct: 64 EKELVVLTRLNEKEIKKIVKLKIHNLVVKILLP-ISDLHIKEKLNFSNKYYIQKIKDCLD 122 Query: 116 ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMS 175 I + G+D T+ E L + +++ Y + D+ G Sbjct: 123 -------ILKKDKKGVDIC--FEDGTRTSREKLKEYMEIISKYQVRTVTFADTVGCSTPL 173 Query: 176 DIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 + D F + H H++L L AN++AA+ G +I+ + G+G AGNAP Sbjct: 174 EYGDIFNYFVKKY-SNIIFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGERAGNAP 232 Query: 236 LEVFIAAADK 245 +E I K Sbjct: 233 IEEIITILTK 242 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 51.6 bits (122), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 110/273 (40%), Gaps = 51/273 (18%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDGM ++++ ++A+ LDD V IE G GS+ Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIE----GGWPGSN------- 50 Query: 64 HSDLEWIEAAADV-VKHAK-------------------IATLLLPGIGTIHDLKNAWQAG 103 D+++ E AA + K+A+ I LL G + + W Sbjct: 51 PRDVQFFEKAAKIDFKNARLTAFGSTRRAGLAVEKDDNIRLLLECGAPAVALVGKTWDL- 109 Query: 104 ARVVRVATHCTEADVSAQHIQYA------RELGMDTVGFL----------MMSHMTTPEN 147 + V ++ E+++ H A RE+ D F + +T + Sbjct: 110 -HITEVMSNTLESNLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQA 168 Query: 148 LAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVA 207 A L + G + V++ A + + DRF + Q G+H H++ +L VA Sbjct: 169 GADAVILCDTNGGALPHDVEAITAEVCTTLADRFPG--PDGGSTVQVGIHTHNDSNLAVA 226 Query: 208 NSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 NSIAA+ G + ++ G G GNA L I Sbjct: 227 NSIAAIRAGARIVQGTINGYGERCGNADLTSII 259 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 51.6 bits (122), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 65/273 (23%), Positives = 111/273 (40%), Gaps = 42/273 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++Y D TLRDG + +L+ ++A L+ VD +E GF A Sbjct: 3 NRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEA-------------GFPA 49 Query: 64 HS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVS 119 S D E ++ A ++A L G D+ W+A AR R+ + + + Sbjct: 50 SSPGDFESVQRIAAQAGDIQVAGLARCVAG---DIDRCWEAIKNARNPRIHIFLSTSPLH 106 Query: 120 AQH-------------IQYARELGM--DTVGFLMMSH-MTTPENLAKQAKLMEGYGATCI 163 +H ++ + M D V F + PE L + + + GAT + Sbjct: 107 MRHKLRKDPDDVLRMAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTV 166 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQT--GMHAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G ++ R + + + +H H++L L VAN++AA G + + Sbjct: 167 NLPDTVGYAQPAEYAARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAE 226 Query: 222 ASLAGMGAGAGNAPLEVFI----AAADKLGWQH 250 +L G+G AGNA LE + D G +H Sbjct: 227 VTLNGIGERAGNASLEEVVMNLRVRQDYFGLEH 259 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 51.6 bits (122), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 60/277 (21%), Positives = 109/277 (39%), Gaps = 45/277 (16%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 ++ K + + D TLRDG ++L + +IA LD+ V+ IE G GS+ Sbjct: 28 VSKKSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIE----GGWPGSN---- 79 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTI--------HDLK--------------- 97 D E+ + +K K++ + G+ D+ Sbjct: 80 ---PKDEEFFKE----IKKYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIF 132 Query: 98 -NAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAK 153 +W A V T D+ I Y R G+ + P+ + K Sbjct: 133 GKSWSLHATEVLKVTKQDNLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYALEVVK 192 Query: 154 LMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAV 213 E GA I + D+ G ++ + + ++ L + G+HAH+++ VANS+ A+ Sbjct: 193 TAESAGADVIALADTNGGTPPFEVYEITKKVREVL--HVKLGIHAHNDIGCAVANSLMAI 250 Query: 214 EEGCDRIDASLAGMGAGAGNAPL-EVFIAAADKLGWQ 249 + G + ++ G+G GNA L ++ K+G+ Sbjct: 251 KAGARHVQGTINGIGERTGNADLIQIIPTLVLKMGFN 287 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 51.2 bits (121), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 68/259 (26%), Positives = 105/259 (40%), Gaps = 46/259 (17%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + SD TLRDG QIAKAL+ A V S++ G SS + Sbjct: 30 VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDA----GFPASS-------QA 78 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQH-- 122 D++ I++ V+K + L G + A R V+ C + + Q Sbjct: 79 DIDAIQSMVGVIKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKL 138 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAK--LMEGY------GA 160 IQYA E D V F +PE+ ++ L E Y GA Sbjct: 139 EKSKSEVLKLIVDSIQYAAE-KFDIVAF-------SPEDASRTEVDFLCEVYREAIAAGA 190 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCD 218 T I D+ G + +D ++ E+ +H H++L L VAN++A ++ G + Sbjct: 191 TTIGFPDTVGILTPWKAQDFICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGAN 250 Query: 219 RIDASLAGMGAGAGNAPLE 237 + ++ G+G AGNA LE Sbjct: 251 VVQCTVNGIGERAGNAALE 269 >UniRef50_C1YV80 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YV80_NOCDA Length = 328 Score = 51.2 bits (121), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 97/241 (40%), Gaps = 24/241 (9%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ I DVTLRDG + +++ VR+ K L + V +EV + G Sbjct: 11 RRPRILDVTLRDGGYLNDWRFTDATVREHTKVLGEVGVPYVEVGYISDDPGREPT----- 65 Query: 64 HSDLEWIEAAADVVKH-------AKIATLLLPGIGTIHDLKNAWQAGARV---VRVATHC 113 + A D+++ A++ +L + ++ + A V VR+ Sbjct: 66 ------LRCAPDLLRQVGEDAGPARVVAMLAVNGRSPDEVAALLRPRAEVLDVVRLTCLL 119 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGGAM 172 D + R G+ L+ P LA A+ + G A +Y+ DS GA+ Sbjct: 120 ERLDHVLAAAEAVRASGVTCSLNLISVTAYEPGELAGAAERVARAGVADWLYLADSRGAL 179 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + F ++A G H H NL VANS A+E G D +D SL G G G G Sbjct: 180 LPEHAAELFAGVRAAWP--GLAGFHGHDNLGHAVANSRIALEAGFDLVDGSLHGYGLGGG 237 Query: 233 N 233 N Sbjct: 238 N 238 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 109/255 (42%), Gaps = 32/255 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH------------- 48 N KK+ + D TLR+G ++ + QIA LD VD IE++ Sbjct: 23 NPKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEISPVVSNDHKEATKTI 82 Query: 49 -GDGLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV 107 GL+ ++G D I+ + D AK L GI IH LK+ R+ Sbjct: 83 IKQGLKADIVSHGRALKED---IDVSLDC--DAKWCAAYL-GISDIH-LKDKL----RIS 131 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 R + + + ++YA+ G+ + PE L K K +E G I + D Sbjct: 132 REDA----MERAVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPD 187 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + + + + ++ + + H H+++ VAN+ +A + G D+I ++ G+ Sbjct: 188 TVGILRPIGMYNFVKKVRDSI--DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGI 245 Query: 228 GAGAGNAPL-EVFIA 241 G G PL EV +A Sbjct: 246 GERTGIPPLAEVAVA 260 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 110/257 (42%), Gaps = 40/257 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG + E IA+ L VD IE GF Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEP-------------GFAI 48 Query: 64 HSDLEW--IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 S E+ I+ + +++ +I I A Q A+ R+ + +D+ Sbjct: 49 SSPGEFAAIQQISRELQNVEICGFARAVKVDIDAAVKATQDAAKR-RLHLFISSSDIHLS 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEG---YGATC 162 H I YA++ +D + F M + + +L+E GAT Sbjct: 108 HQIRKTRSEVVQIARDMISYAKQF-VDEIQFAAMDSTRSDRDFV--IELVEAAIESGATI 164 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G +++ D F +++ + + + + H H++L + VANS+AAV+ G ++ Sbjct: 165 INLPDTLGYALPNEMVDLFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQV 224 Query: 221 DASLAGMGAGAGNAPLE 237 + ++ G+G AGN LE Sbjct: 225 EVTVNGVGERAGNCSLE 241 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 50.8 bits (120), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 10/100 (10%) Query: 148 LAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM----HAHHNLS 203 LA+ + +E +GA D+ G I D F+ + K T M H H++ Sbjct: 143 LAEYIRTIEAHGADRFRFCDTVG------ILDPFKTYELTAKIREITSMDIEIHTHNDFG 196 Query: 204 LGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 + AN++AAV G ++ ++ G+G AGNAPLE I A+ Sbjct: 197 MATANALAAVRAGATHVNTTVIGLGERAGNAPLEEIIMAS 236 >UniRef50_Q2S361 3-hydroxy-3-methylglutaryl-CoA lyase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S361_SALRD Length = 307 Score = 50.8 bits (120), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 13/143 (9%) Query: 123 IQYARELGMDT-VGFLMMSHMTTP-----ENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 ++YA E G+ +GF + P + + ++ G + + DS G + Sbjct: 128 VRYAHEHGLAVQMGFQTVFGYQAPGDTPLDQVVDMSRHFADLGVESLSLADSTGLAHPRM 187 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG------AG 230 I++R RA++A + +T +H H LG+AN AA++ G +R D SLAGMG Sbjct: 188 IKERVRAVQAAIG-DTPLVLHLHDTRGLGLANVYAALQCGVERFDTSLAGMGGCPFIDGA 246 Query: 231 AGNAPLEVFIAAADKLGWQHGTD 253 GN E D LG + G D Sbjct: 247 TGNIATEDTAYLLDGLGIETGVD 269 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 50.8 bits (120), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 106/255 (41%), Gaps = 34/255 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG ++ E IA+ L D VD +EV G G Sbjct: 10 KKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEV--GIPTMGGDEK----- 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 +A ++VK +++ + D++ + G V VA + +D+ QH Sbjct: 63 -------KAIKEIVKRNLKPSIMAWNRAVVSDIEQSIDCG--VDAVAISISVSDIHIQHK 113 Query: 123 IQYARELGMDT----VGFLMMSHMTTPEN-----------LAKQAKLMEGYGATCIYVVD 167 ++ +RE +++ V F + + N L + + GA D Sbjct: 114 LKTSREWVLESMVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCD 173 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G M IRD + + + + + MH H + + AN++A ++ G + ++ G+ Sbjct: 174 TVGIMEPFKIRDDIKYIYDKTGFDIE--MHTHDDFGMATANAVAGIKGGASHVGVTVNGL 231 Query: 228 GAGAGNAPLEVFIAA 242 G AGNA LE I A Sbjct: 232 GERAGNAALEEVIMA 246 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 50.8 bits (120), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 108/269 (40%), Gaps = 44/269 (16%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHG----DGLQGSSFNYGFGA 63 + D TLR+G Y+ E +IA ALD+ VD IE+ H D +G G Sbjct: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------D 117 + +L + H++ I D+ + G V + +EA Sbjct: 62 NVEL---------LAHSR---------ALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFR 103 Query: 118 VSAQH--------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 ++ H I+YA++ G+ + T NL + +L + I V D+ Sbjct: 104 ITLDHALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTT 163 Query: 170 GAMNMSDIRDRFRAL-KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G+ + RF L K + +H H++L L +AN+I +E G +DA++ G+G Sbjct: 164 GSTHPL----RFYTLVKKIVNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLG 219 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 AG L I L + +G Y L Sbjct: 220 ERAGIVDLAQIITV---LYYHYGIKKYRL 245 >UniRef50_C0FY13 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans DSM 16841 RepID=C0FY13_9FIRM Length = 492 Score = 50.8 bits (120), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 8/112 (7%) Query: 165 VVDSGGAMNMSDIRDRFRAL-KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---I 220 +VD+ G+M D+ DR +L L + + G+H H N++L + + V+ +R + Sbjct: 130 IVDTFGSMKRRDL-DRIVSLVDNNLSKDIRVGLHLHENMALSFSLAQRFVDCHLNRPITV 188 Query: 221 DASLAGMGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRPLQDR 271 D SL GMG GN P+E+ ++ + ++ D LMDA D ++P++++ Sbjct: 189 DGSLLGMGRIPGNLPIELIADYVNEYVDNRYNIDF--LMDAIQDYIQPIKEK 238 >UniRef50_C0WJX1 Possible pyruvate carboxylase n=1 Tax=Corynebacterium accolens ATCC 49725 RepID=C0WJX1_9CORY Length = 518 Score = 50.4 bits (119), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 75/321 (23%), Positives = 132/321 (41%), Gaps = 34/321 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRD +I + I LDD E H D + F+ Sbjct: 29 RKINIIDTTLRDAHQSI--WATRMTTSHILSLLDDITNAGFE--HVDLVAPIQFDVSVRY 84 Query: 64 HSDLEWI------EAAAD------VVKHAKIATL-LLPGIGTIHDLKNAWQAGARVVRVA 110 + W E AA +++ +A+ LP ++ + + G RV+ Sbjct: 85 LKEDPWERVRLVHENAAPGTKFRALIRSKNLASFDFLPDDAILNWTERLYANGFRVIGSF 144 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTP---ENLAKQ--AKLMEGYGATCIYV 165 + D Q ++ A+ELG +T G L S+ +P ++L K+ +L+E I + Sbjct: 145 DGLNDIDNIDQGLKLAKELGAETFGAL--SYCLSPVHTDDLYKRKATELLERTDVDRIML 202 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+GG + ++ A+++ + + +H H L + A E G D I S+A Sbjct: 203 KDAGGLLTPDRLKTLIPAIRSSIG-DVPLEVHTHSLTGLSPLTYLYAAELGVDSIHTSIA 261 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL---QDRPVRVDRETLAL 282 + G G + + LG+ D +D+A + ++ + +D+PV V R L Sbjct: 262 PLANGPGQPATQAVVRDLRALGYTVDVD-DERIDSASERIQEIADTEDKPVGVPRAFDGL 320 Query: 283 GY-----AGVYSSFLRHCETA 298 Y G+ ++F ETA Sbjct: 321 HYMHQLPGGMLTNFESQLETA 341 >UniRef50_A1WEM7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WEM7_VEREI Length = 332 Score = 50.4 bits (119), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 63/138 (45%), Gaps = 7/138 (5%) Query: 133 TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPET 192 + G M M+ L A+ +E +GA + + D+ G + AL+A P T Sbjct: 153 SFGCPMEGDMSEATVLDGCARFIEQFGAQGVTLCDTTGMAYPGQVFALTCALRARW-PGT 211 Query: 193 QTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKL 246 + +H H +G+AN +AA++ G D SL G+G +GN E A + + Sbjct: 212 ELTLHFHDTRGMGLANVMAAIDAGATHFDVSLGGLGGCPYAPGASGNVCSEGIAHALECM 271 Query: 247 GWQHGTDLYALMDAADDL 264 G+ G DL L+ AA L Sbjct: 272 GYDTGIDLALLIAAAQRL 289 >UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria RepID=Q1IM73_ACIBL Length = 520 Score = 50.4 bits (119), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 20/273 (7%) Query: 3 GKKLYISDVTLRDGMHAIR-HQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 G+ + ++D+ LRD ++ + ++E++ + LD+A S+E G++F+ Sbjct: 19 GRIIEVTDLILRDAHQSLMATRMAMEDMVPACEDLDNAGYWSLEC-----WGGATFDSCI 73 Query: 62 GAHSDLEW--IEAAADVVKHAKIATLL----LPGIGTIHD------LKNAWQAGARVVRV 109 ++ W + ++ K+ LL L G D + A + G V RV Sbjct: 74 RFLNEDPWERLRQFKKLLPKTKLQMLLRGQNLLGYRHYEDSVVERFVAKAAENGMDVFRV 133 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFL--MMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I+ ++ G G + +S + T + AK ++ G I + D Sbjct: 134 FDALNDIRNLQTSIKAVKKTGKHAQGTISYTISPVHTITAFVEMAKQLKEMGCDSICIKD 193 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + D + +K + +H H + + + + AVE GCD +D +++ M Sbjct: 194 MAGLLKPQPAYDLVKGIKEACGDDMLVHVHCHATTGVTLVSLMKAVEAGCDMVDTAISAM 253 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDA 260 G G+ P E F+ + G++ D+ ++ A Sbjct: 254 CLGPGHNPTESFVEMLEGTGFETKLDMARILKA 286 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 58/248 (23%), Positives = 109/248 (43%), Gaps = 32/248 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ D T+RDG I ++++ ++A+AL+ V +IE GF A Sbjct: 10 QITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEA-------------GFPAA 56 Query: 65 S--DLEWIEAAADVVKHAKI---ATLLLPGIGTI--------HDLKNAWQAGARVVRV-A 110 S D + + + VV AK+ A L+ I + H + + + A + V R Sbjct: 57 SKKDFDAVVEISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYK 116 Query: 111 THCTEADVSAQ---HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 H + +++ + I+Y + + + + + T PE LA+ + GAT I + D Sbjct: 117 LHMSPSEIIEKVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPD 176 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQT--GMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + + F L+ ++ Q H H++L + AN++A + G I ++ Sbjct: 177 TVGYATPYEYGELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTIN 236 Query: 226 GMGAGAGN 233 G+G AGN Sbjct: 237 GIGERAGN 244 >UniRef50_D1Y2H6 Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y2H6_9BACT Length = 300 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 52/111 (46%), Gaps = 7/111 (6%) Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ G + R A++ E ++ +H H +G+AN A+EEG +D+SL Sbjct: 177 IADTAGISTPENTRRVVTAIR-EYTDLSKVSLHMHDTYGMGLANCYVAMEEGITMMDSSL 235 Query: 225 AGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ 269 AGMG GN E + DK+G + G DL L A ++ +Q Sbjct: 236 AGMGGCPFVPGAKGNIATEDLVYMLDKMGVETGYDLNKLNQTAAEMAAEIQ 286 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 61/282 (21%), Positives = 111/282 (39%), Gaps = 34/282 (12%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 ++ D TLRDG A + + ++A+ L + +D IEV G A + Sbjct: 6 FLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEV-------------GIPAMGE 52 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVA-------------THC 113 E ++V+ + + D++ A GA + +A T+ Sbjct: 53 DEC-NTIQNIVRLKLRPIISVWSRAIKKDIEQASTLGATCIHIAFPLSDIQLQAINKTYG 111 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGATCIYVVDSGGAM 172 D ++ IQ A+ L + V P + + + + E YG + D+ G + Sbjct: 112 WVEDTFSKTIQCAKNL-FERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGIL 170 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + R +K + K HAH++ + AN++ A + G + + ++ G+G AG Sbjct: 171 TPIQTIEIIRTIKKK-KTNMNIDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAG 229 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQD 270 NA LE + ++ + DL L D + RPL D Sbjct: 230 NAALEEILMGLRQINGKTKYDLSTLFDLCRYVSVISGRPLPD 271 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/283 (22%), Positives = 116/283 (40%), Gaps = 43/283 (15%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I++V RDG+ + S+E+ + +AL + ++E G + + G Sbjct: 2 KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEA--GSFVSPKAVPQMAGT- 58 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKN---AWQAGARVVRVATHCTEA----- 116 DL + V++A G + ++K A AGA VV V TE Sbjct: 59 DDLFALLPERSAVRYA----------GLVPNMKGYELAVAAGANVVNVVLSVTETMNQKN 108 Query: 117 ---------DVSAQHIQYARELGMDTVGFLMMSH------MTTPENLAKQAKLMEGYGAT 161 +V I+ R G++ +L ++ + P +A+ AK +E GA+ Sbjct: 109 IRMSLPQTVEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGAS 168 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 I + D+ GA N +R + +E+ + + H H + +AN AA++ G D Sbjct: 169 KIIIADTIGAANPEHVRRLLNGVISEVGSDILS-CHFHDTRGIALANITAALDHGIREFD 227 Query: 222 ASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALM 258 S+ G+G GN E + + +G G + + L+ Sbjct: 228 TSIGGLGGCPFSPGATGNVATEDVVLLLNSMGHDTGINPFDLV 270 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 67/274 (24%), Positives = 111/274 (40%), Gaps = 63/274 (22%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS-- 65 + D TLRDG + + + IA+ L VD IE GF A S Sbjct: 91 VFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEA-------------GFPAASKD 137 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTI-----HDLKNAWQA--GARVVRVATHCTEADV 118 D E ++ A+ V + +P I + D++ AW A A+ R+ T +D+ Sbjct: 138 DFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDI 197 Query: 119 SAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAK--LME---- 156 ++ +++AR LG + V F +PE+ + + L E Sbjct: 198 HLEYKLKKTKAEVIEIARSMVRFARSLGCEDVEF-------SPEDAGRSEREYLYEILGE 250 Query: 157 --GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQ------TGMHAHHNLSLGVAN 208 GAT + + D+ G S+ F L +LK T H ++L L AN Sbjct: 251 VIKAGATTLNIPDTVGITLPSE----FGQLITDLKANTPGIENVVISTHCQNDLGLSTAN 306 Query: 209 SIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +++ G +++ ++ G+G AGNA LE + A Sbjct: 307 TLSGAHAGARQMEVTINGIGERAGNASLEEVVMA 340 >UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN Length = 370 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 62/129 (48%), Gaps = 7/129 (5%) Query: 144 TPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLS 203 TP+ + + +K + G G I + D+ G ++ ++ E+ P +H H Sbjct: 226 TPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGA-LAVHCHDTYG 284 Query: 204 LGVANSIAAVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 +AN + A++ G + +D++++G+G +GN E I + LG G +LY + Sbjct: 285 QALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKV 344 Query: 258 MDAADDLVR 266 M+A D + + Sbjct: 345 MEAGDFICK 353 >UniRef50_UPI0001B521AE 2-isopropylmalate synthase n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B521AE Length = 233 Score = 49.7 bits (117), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/124 (32%), Positives = 66/124 (53%), Gaps = 7/124 (5%) Query: 116 ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN-- 173 +D +A+ ++YAR LG+D + L+M T + + ++ G GAT + + D GAM+ Sbjct: 12 SDAAARLVRYARSLGLDVIVPLLMVSYLTEDAHEEAVTVLTGAGATELTLFDGPGAMSPE 71 Query: 174 -MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + R R L P+ + G+H H+ L VA ++AAV G ++ S+ G G G Sbjct: 72 AYAPLVHRTRTLA----PDVEVGLHPHNTFGLAVACAVAAVRAGATAVELSVNGYCGGPG 127 Query: 233 NAPL 236 NA L Sbjct: 128 NADL 131 >UniRef50_C5EHC6 Pyruvate carboxylase subunit B n=2 Tax=Clostridiales RepID=C5EHC6_9FIRM Length = 465 Score = 49.7 bits (117), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 78/185 (42%), Gaps = 27/185 (14%) Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 G+ A+ D + +E + A I L+ + DL+N ++ R V+ A E Sbjct: 110 GYKAYPD-DVVEKFVEKAAAAGIDVFLI--FDALQDLRNC-ESAFRAVKKAGKKIEGS-- 163 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 IQY +S T E + K E G + ++V D G M + D Sbjct: 164 ---IQYN------------ISPFHTIEKFVENGKEQEKMGVSLLHVEDMAGLMTPAAAYD 208 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSI--AAVEEGCDRIDASLAGMGAGAGNAPLE 237 +ALKAELK +H H + + G+A A+ G D +D ++ M G + P+E Sbjct: 209 LIKALKAELK----VPIHLHCHCTGGMAEMAYWEAIRAGVDGLDVCVSSMSMGPAHPPIE 264 Query: 238 VFIAA 242 F+ A Sbjct: 265 SFVTA 269 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 105/259 (40%), Gaps = 49/259 (18%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG +S E+ +IA+ L + V+ IE G+ S Sbjct: 29 QKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEA----GMPAVS------- 77 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV-------------RVA 110 D + IE A KI D+ A GA + + A Sbjct: 78 KDDAQAIEEIAKRNLGPKIMVFCR---AMREDVDRAVDCGADGIVLEAPSGYPKLKYQFA 134 Query: 111 THCTEADVS---AQHIQYARELGM-------DTV--GFLMMSHMTTPENLAKQAKLMEGY 158 + TE ++ I YA+E G+ DT + + T N+ QAK Sbjct: 135 SKWTEESLTEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLT--NVTTQAK----- 187 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 + VVD+ G++ + +R R ++ + + +H H++ LG A + AAVEEG Sbjct: 188 -PDSVTVVDTTGSITPTAMRFLVRQVRETIALPLE--VHTHNDFGLGTATTFAAVEEGVQ 244 Query: 219 RIDASLAGMGAGAGNAPLE 237 + + + G+G GN LE Sbjct: 245 VVHSCINGLGERTGNTALE 263 >UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK Length = 285 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 40/235 (17%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 KL I D TLRDG + + + +IA+ L+ RVD IE GF A Sbjct: 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEA-------------GFAAS 50 Query: 65 S--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEA---- 116 S D E ++ A+ +K + + +L D+ A +A GA R+ T + Sbjct: 51 SNGDFEAVQLIANSIKDSTVCSL---SRANDRDIARAAEALKGANSARIHTFIATSALHM 107 Query: 117 ------------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + + Q +++AR L D + + P+ L + + + GA+ I Sbjct: 108 EKKLRMTPEQVLEQAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGM---HAHHNLSLGVANSIAAVEEG 216 V D+ G + ++ F E P + + H H++L + VANS+A V+ G Sbjct: 168 VPDTVG-YAVPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIG 221 >UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD Length = 314 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 72/168 (42%), Gaps = 13/168 (7%) Query: 123 IQYARELGMDTVGFLMMSH------MTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 I ARE G+D G++ M + E + + + G T + + D+ G + Sbjct: 143 IARAREAGLDVRGYVSMCFGDPWEGIVPTEQVVTVGRRLLDAGCTQLSLGDTIGVATAAA 202 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG------AG 230 + A +H H +AN++AA+ +G +DAS G+G + Sbjct: 203 VERLLDAFIEGGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDASAGGLGGCPYAESA 262 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRVDR 277 GN E + D LG +HG DL AL++ + + R L + P RV R Sbjct: 263 TGNLATEDLVWLLDGLGVEHGVDLDALVETSRWMSRQLGRSSPSRVVR 310 >UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI Length = 311 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 8/117 (6%) Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + V D+ G N + + F LK L PE H H + +AN +A+++ G DR D Sbjct: 185 LSVADTIGMANPKESFELFSLLKKTL-PEVLMTAHFHDTRKMALANILASLQAGVDRFDT 243 Query: 223 SLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPV 273 S G+G +GNA E + ++G + G DL +L AA +LV P R + Sbjct: 244 SAGGLGGCPFAPGASGNAATEDVVFMLHQMGIETGVDLDSLT-AAVNLVAPHLSRTI 299 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 65/260 (25%), Positives = 103/260 (39%), Gaps = 36/260 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I D TLRDG + SL+ +IA+AL VD IE GF Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEA-------------GFPV 51 Query: 64 HSDLEW--IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 +E+ + A VK IA L I A + + R+ + + V Q Sbjct: 52 SGPMEFEAVRRIATEVKGPIIAALARTHTLDIDQAAKALEKAEK-PRIHVFTSASKVHLQ 110 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQA-KLMEGYGATCIY 164 + ++YAR +D V F M K+ ++ GAT I Sbjct: 111 YMLRKTEEEVLEMADRMVRYARRY-VDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTIN 169 Query: 165 VVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + R ++ E+ + H H +L + AN++A VE G +I+ Sbjct: 170 IPDTTGYGTPQEYGALIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIEC 229 Query: 223 SLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGN LE + A Sbjct: 230 TINGIGERAGNCALEEVVMA 249 >UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI Length = 974 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 28/158 (17%) Query: 94 HDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAK 153 +D+ AW+A ++ + E ++ + ++YAR LG D V F +PE+ + + Sbjct: 65 NDISTAWEA-YKLKKSEKEVIE--IAREMVKYARSLGCDDVEF-------SPEDAGRSER 114 Query: 154 ------LME--GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQ------TGMHAH 199 L E GAT + + D+ G + + F L A++K T H Sbjct: 115 EFLYKILGEVIKAGATTLNIPDTVGYT----VPNEFGQLIADIKSNTPGIENVIISTHCQ 170 Query: 200 HNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 ++L L AN+IA G +++ ++ G+G AGNA LE Sbjct: 171 NDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLE 208 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 69/263 (26%), Positives = 107/263 (40%), Gaps = 41/263 (15%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + +LE IA+ L VD IE + F + Sbjct: 7 RVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAG-----------FPFASQ 55 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR--VATHCTEADVSAQH 122 D ++ A V + + + D+K A A R + T +D+ +H Sbjct: 56 GDFSAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEH 115 Query: 123 ----------------IQYARELGMDTVGFLMM-SHMTTPENLAKQAKLMEGYGATCIYV 165 + YAR L +D V F + + PE L + + GA I + Sbjct: 116 KLRKSRAEVLAIVPEMVAYARSL-VDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINI 174 Query: 166 VDSGGAMNMSDIRDRFRALKAELK---P---ETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 D+ G S+ F AL A + P E +H H++L L VAN + AV+ G + Sbjct: 175 PDTVGFTTPSE----FGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQ 230 Query: 220 IDASLAGMGAGAGNAPLEVFIAA 242 + ++ G+G AGNA LE + A Sbjct: 231 FECTINGIGERAGNAALEELVMA 253 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 48.9 bits (115), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 101/240 (42%), Gaps = 16/240 (6%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M K+ I+D TLR+G A ++S+ + IA ALD VD IE+ H L G Y Sbjct: 1 MQRKRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHP--LAGP---YE 55 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGT-------IHDLKNAWQAGARVV-RVATH 112 + + A ++ HA+ + + I N ARV+ R T Sbjct: 56 HQRTEAVAKLGLGAKIIAHARAHRTDIEAVSRTGATWVGIFLGVNDITTKARVIGRSTTE 115 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + A ++ A++ G++ + T L GA I D+ G Sbjct: 116 LIR--MVADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICYADTLGIA 173 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 +++ + +K+E P+ + +H H + L +ANS+AA++ G D I S+ +G G Sbjct: 174 EPAEVARKVTLMKSEF-PDAEVEVHLHDDRGLAMANSLAAIDAGVDSISVSVNALGERCG 232 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 48.9 bits (115), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 22/245 (8%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLR+G ++ + IAK LD VD IE+ + F +H Sbjct: 40 IIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNP-----------FASHQAR 88 Query: 68 EWIEAAADVVKHAKIATL-------LLPGIGTIHDLKNAWQAGARVVRVATHCTEA---- 116 E A A++ AKI + + T D + + A + +R +H Sbjct: 89 EDCRAIANLGLKAKIVAHTRCHMDDVRACVETGIDGVSMYMATSEALRRHSHGKSVQAVI 148 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 D + + I++ ++ GM+ + + L ++ G + + D+ G Sbjct: 149 DSAREVIEFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGIATPFQ 208 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 + + A+++ +KPET H H++ +AN++ A++ G I+ + G+G G PL Sbjct: 209 VAETVAAVRSIIKPETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERNGITPL 268 Query: 237 EVFIA 241 F+A Sbjct: 269 GGFLA 273 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/263 (23%), Positives = 106/263 (40%), Gaps = 49/263 (18%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 N + + I D TLRDG ++ + +IAK L DA V+ IE G Sbjct: 25 FNRENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEA-------------G 71 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTI-----HDLKNAWQAGARVVRVATHCTE 115 F A S+ D +K K + I ++ +D+ ++ +R++ + ++ Sbjct: 72 FPAVSN--------DEMKSIKKINHDMENICSLARCNRNDIDKVIESDSRIIHLFIATSD 123 Query: 116 A--------------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT 161 D + I YAR GM + F T + KQ ++ Sbjct: 124 IHMKYKLKKTREQVFDSIMESIDYARSYGMRII-FSPEDATRTSMDFLKQ--IVSSIKVE 180 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGM--HAHHNLSLGVANSIAAVEEGCDR 219 I D+ G MN + ++K T TG+ H H++ + AN++A + G + Sbjct: 181 TINFPDTIGIMNPISMY----YFINKIKSFTSTGISIHCHNDFGMATANTLAGLMAGANE 236 Query: 220 IDASLAGMGAGAGNAPLEVFIAA 242 ++ G+G AGNA LE +++ Sbjct: 237 AQVTVNGIGERAGNASLEEVVSS 259 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 102/251 (40%), Gaps = 30/251 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 +L+I D TLRDG Q + Q+AKAL+ VD IE G F Sbjct: 4 RLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGD-FKSVVEIS 62 Query: 65 SDLEW-------------IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVAT 111 + W I+ AA+ ++ AK + GIGT ++ Sbjct: 63 KAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIH-TGIGT----------SDSHIKYKF 111 Query: 112 HCTEADVSAQHI---QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + T ++ + I +YA++ D + + T E LA+ + + GAT + + D+ Sbjct: 112 NSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDT 171 Query: 169 GGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + + L + H H++L + AN++ V G +++ ++ G Sbjct: 172 TGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTING 231 Query: 227 MGAGAGNAPLE 237 +G AGN LE Sbjct: 232 IGERAGNTSLE 242 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 48.5 bits (114), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 6/119 (5%) Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 GAT + + D+ G N + + R + G+H H+ LG+AN++A + G Sbjct: 175 GATEMVLADTTGMANPRQVAETVRGFYRTFGEDIPLGLHFHNTRGLGLANAVAGYDAGVR 234 Query: 219 RIDASLAGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 R D+++ G+G GN E + ++G GTDL L+ A + + + R Sbjct: 235 RFDSAVGGLGGCPFAPKATGNICTEDLVHMFHEMGIDTGTDLDGLITLAQQVEKWMGKR 293 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 48.5 bits (114), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 22/51 (43%), Positives = 32/51 (62%) Query: 196 MHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 H H++L + AN+IAA+E G + ++ G+G AGNAPLE + AA L Sbjct: 195 FHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAGNAPLEQVVVAAGTL 245 >UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PPD2_9SPIO Length = 624 Score = 48.5 bits (114), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 6/129 (4%) Query: 137 LMMSHMTTP----ENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPET 192 + +S TTP + A+ AK +GA I + D G + D D A+K K Sbjct: 142 MAISFATTPYHTIDKYAELAKTYTEFGADSICIKDMAGLLKPFDAFDLVTAIKK--KTSI 199 Query: 193 QTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGT 252 +H H L VA + A E G D +D +++ M G ++P E + G Sbjct: 200 PINIHTHATTGLSVATLLKAAEAGADILDTAISSMSMGTSHSPTETMVEIFRGTEMDTGL 259 Query: 253 DLYALMDAA 261 D+ L++ A Sbjct: 260 DINLLLEIA 268 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 56/247 (22%), Positives = 103/247 (41%), Gaps = 24/247 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 ++I D TLRDG Q + Q+A++L+ VD IE G FN Sbjct: 11 VFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPGD-FNSVIEISK 69 Query: 66 DLEW-------------IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 + W I+ AA+ +++AK + GIGT + + + Sbjct: 70 SVTWTIICALTRAIEKDIDIAAESLQYAK-RKRIHTGIGT-----SPYHIKYKFNSTQDE 123 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 E V++ ++YA++ D + + T LA+ + + GA + + D+ G Sbjct: 124 ILERAVAS--VKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVNIPDTTGYC 181 Query: 173 NMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + + L +K H H++L + AN+I+ + G +++ ++ G+G Sbjct: 182 LPEEYGAKIKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEVTINGIGER 241 Query: 231 AGNAPLE 237 AGN LE Sbjct: 242 AGNTSLE 248 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 64/272 (23%), Positives = 113/272 (41%), Gaps = 48/272 (17%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG +S E +A LD ++ IE GF S Sbjct: 23 IEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEA-------------GFPVVS 69 Query: 66 --DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 + E ++ A+ +++I L G D+ A + +V + ++ + ++ Sbjct: 70 ADEKEIVKEIANQGFNSRICCLSRAVKG---DVDAALECDVDIVSIFIAMSDMHLKYKYH 126 Query: 123 -------------IQYARELGMDTVGFLMMSHMTTPENLAKQA--KLMEGYGATCIYVVD 167 I+YA + G+ V F TP KQA ++ Y + + D Sbjct: 127 RSLEDMLGCAKEAIEYATDHGLK-VRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLAD 185 Query: 168 SGGAMNMSD----IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + G +N + + + F+++ T +H H +L + AN++AA E G ++ + Sbjct: 186 TVGILNPTTTNYLVSEIFKSVN------TAICIHCHDDLGMATANTLAAAEAGAKQLHTT 239 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLY 255 + +G AGNA LE + A L Q+G + Y Sbjct: 240 VNAIGERAGNASLEEVLVA---LRVQYGIERY 268 >UniRef50_D2SNE9 HMG-CoA lyase-like protein n=1 Tax=Streptomyces fradiae RepID=D2SNE9_STRFR Length = 333 Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 98/230 (42%), Gaps = 16/230 (6%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ++DVTLRDG + H ++ + + +A+ A V IEV + + G++F Sbjct: 20 VQVTDVTLRDGGYLNDHSWTADRAHAVVRAVSAAGVRRIEVGYANA--GAAFPS------ 71 Query: 66 DLEWIEAAADVVKHAKIAT--LLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 D+V A AT +++ G D G VR A + Sbjct: 72 ----PALLGDLVAAAGPATVVMMVKPFGDEPDWAALAGRGVGAVRFPVAVARAAELGPVL 127 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 AR G++T L+ +++ A GA +YV DS G++ + RA Sbjct: 128 DRARRAGLETAVNLIRVSAEALDSVVGAAVAAAELGAGTLYVADSNGSLTPHATDELVRA 187 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 L + G H H NL L +ANS+AA+ G +DAS G+G G GN Sbjct: 188 LCRAVP--VPIGFHGHDNLRLALANSLAALRAGAAHVDASFDGIGKGGGN 235 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 26/245 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG + +++ +IA L D VD IE GF A Sbjct: 27 KRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIET-------------GFAA 73 Query: 64 HSDLEWI------EAAADVVKHAK-----IATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 S E + E + + A+ I +++ GI IH + + Sbjct: 74 VSSEESMAIRKIHEMDGNFISLARCNRHDIDSVIDTGIDNIHLFIATSDIHIKYKLKTSR 133 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + I YAR G++ + + T L GA I + D+ G M Sbjct: 134 ENIMEKIVDSIDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIM 193 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 N + + +K K + +H H++ + AN++AA+ G D ++ G+G AG Sbjct: 194 NPISMYNFIHEIKNRTK--SCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAG 251 Query: 233 NAPLE 237 NA LE Sbjct: 252 NAALE 256 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 108/268 (40%), Gaps = 51/268 (19%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG ++ E IA+ L V SIE GF A Sbjct: 18 KEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEA-------------GFPA 64 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 S E+ EA + + ++ D+ A A + V ++ + Sbjct: 65 VSQGEF-EAVKAIAREGLGPEIVALARANKRDIDKALDADVDAIHVFIAASDIHLKYKLR 123 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPEN--------LAKQAKLMEGYGAT 161 + + ++YA+ G+ TV F +PE+ L + + GA Sbjct: 124 MTREEALRRAVEAVEYAKSHGV-TVEF-------SPEDGTRADLNYLYTMVEAVVDAGAD 175 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQ---TGMHAHHNLSLGVANSIAAVEEGCD 218 + + D+ G M + R + L + P + +H H++ L VANSIA +E G Sbjct: 176 RVDIPDTVGVMTPT----RMKYLIKFILPAAKGRIVSVHCHNDFGLAVANSIAGIEAGAR 231 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAADKL 246 + ++ G+G AGNA LE +AA + L Sbjct: 232 QAHVTVNGIGERAGNAALEEVVAALEFL 259 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 48.1 bits (113), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/57 (40%), Positives = 33/57 (57%) Query: 196 MHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGT 252 HAH++L + AN+ +A+E GCD + S+ G+G AGNA LE A G H + Sbjct: 202 FHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGERAGNAALEELAIALKLSGRYHSS 258 >UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=15 Tax=Bacteria RepID=Q2RIA5_MOOTA Length = 643 Score = 47.8 bits (112), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 64/283 (22%), Positives = 115/283 (40%), Gaps = 27/283 (9%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +L I+D TLRDG ++ + + ++ I + +D S+EV G++F+ Sbjct: 29 QLKITDTTLRDGHQSLWATRMTTADMLPIIEKIDSVGYHSLEV-----WGGATFDVCMRF 83 Query: 64 HSDLEWIEAAADVVKHAKIATL-------------LLPGIGTIHDLKNAWQAGARVVRVA 110 + W E + K+A+ L L P + A G ++R+ Sbjct: 84 LDEDPW-ERLRTLKKYARRTPLQMLLRAQSLVGYQLYPDDVVRAFIARAAANGIDIIRIF 142 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++ A++ G+ G ++ +S + T E+ K A +E G I + D Sbjct: 143 DALNDLRNMEVPVEAAKKEGVHVQGTVVYTISPVHTTEHYLKTALELESMGVDSICIKDM 202 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + + K +L Q +H+H+ L V + A G D +D + + Sbjct: 203 AGLLAPFEAYKLVKLFKEKLHVPVQ--LHSHYIGGLAVGAYLEAARAGVDVVDTASVPLA 260 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPL 268 GA P+E + A + + G DL L + A DDL R L Sbjct: 261 FGASQPPVETVVRALEGTPYDTGLDLNLLFEIARYFDDLRREL 303 >UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MGG7_RHOM4 Length = 311 Score = 47.8 bits (112), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/178 (26%), Positives = 77/178 (43%), Gaps = 12/178 (6%) Query: 94 HDLKNAWQAGARVVRVATHCTEADVS-AQHIQYARELGMDTVGFLMMSHMTTPENLAKQA 152 H L NA A VR A EA + A H +LG+ TV T + + + A Sbjct: 108 HSLANANMTVAEAVRQA----EAMIRLAHHYDMQPQLGLQTVFGYKQPGDTPLQRIRELA 163 Query: 153 KLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAA 212 + G + D+ G + I++ A++ E+ +T +H H +G+AN +AA Sbjct: 164 RRFVDLGLESFSLADTTGMAHPVQIQEYVEAVREEIG-DTPLVLHLHDTRGMGLANVLAA 222 Query: 213 VEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 ++ G R D SL G+G GN E + + +G + G D + + A +L Sbjct: 223 LQCGVTRFDTSLGGLGGCPFIPGATGNIATEDTVYMLEAMGVRTGIDYRRVAELALEL 280 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 47.8 bits (112), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 2/102 (1%) Query: 143 TTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELK-PETQT-GMHAHH 200 T PE L + + GAT I + D+ G S+ D + L P+ T H H Sbjct: 153 TDPEFLCEVVQAAAEAGATTINIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHD 212 Query: 201 NLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +L L AN++A + G +++ ++ G+G AGNA LE + A Sbjct: 213 DLGLATANTLAGIRAGARQVECTINGIGERAGNAALEEIVMA 254 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 47.8 bits (112), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 62/264 (23%), Positives = 106/264 (40%), Gaps = 33/264 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV---AHGD------------ 50 + I+D TLRDG A ++ E +IAK L +A D +E+ A G+ Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAEREDIRAILSL 61 Query: 51 GLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVA 110 GL ++ SDLE A + K L +P + A + + +V Sbjct: 62 GLPLRLMSWNRATQSDLE-----ASLACGMKAVDLSIP----VSTKMVAAKFRGKYAKVL 112 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 ++ E + A++ G+ + + L + L GA + D+ G Sbjct: 113 SNLEET------LTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVG 166 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + R+L+ + MH H++ + VANSIA +E G ++ ++ G+G Sbjct: 167 ILTPLQTYRAIRSLRRHCTLPVE--MHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGER 224 Query: 231 AGNAPLE-VFIAAADKLGWQHGTD 253 AGNA E V ++ + G D Sbjct: 225 AGNAGFEQVLLSLIGQFGQNRTLD 248 >UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular organisms RepID=PYCB_METTH Length = 568 Score = 47.4 bits (111), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 68/164 (41%), Gaps = 4/164 (2%) Query: 96 LKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFL--MMSHMTTPENLAKQAK 153 ++ +++ G V R+ + I+ ARE G + +S T E+ A+ Sbjct: 102 IEKSYENGVDVFRIFDALNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFAR 161 Query: 154 LMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAV 213 +E + + D G ++ D + RALK E + +H H + + AA Sbjct: 162 ELEALECDSVAIKDMAGLISPHDAYELVRALKEET--DLMVNLHCHCTSGMTPMSYYAAC 219 Query: 214 EEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 E G D +D +++ + GA P E +AA + G DL L Sbjct: 220 EAGVDILDTAISPLSWGASQPPTESIVAALRDTPYDTGLDLEIL 263 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 47.0 bits (110), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 107/276 (38%), Gaps = 52/276 (18%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKAL-DDARVDSIEVAHGDGLQG----- 54 M + + I D TLRDG +S IA+ L + +VD IEVA +G Sbjct: 1 MTSRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAV 60 Query: 55 SSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 GA+ L+ IE V A I ++ QAGARV+ + T + Sbjct: 61 KKITDWAGANGFLDKIEVLTFVDGDASINWMV--------------QAGARVMNLLTKGS 106 Query: 115 EADVSAQH--------------IQYARELGMDTVGFL---MMSHMTTPENLAKQAKLMEG 157 ++ Q ++ A + G+ +L ++ E + + + Sbjct: 107 LNHLTHQLKKSPEAHFEDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLST 166 Query: 158 YGATCIYVVDSGGAMN-------MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSI 210 I + D+ G + + +I DR+ P+ H H++ LGVAN + Sbjct: 167 LPVKRILLPDTLGILTPFESYTFIKEIVDRY--------PDQHFEFHGHNDYDLGVANVM 218 Query: 211 AAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 A+ G + ++ GMG GNAPL IA + L Sbjct: 219 EALRAGVQGLHLTVNGMGERTGNAPLASTIAVINDL 254 >UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO Length = 277 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/279 (20%), Positives = 115/279 (41%), Gaps = 27/279 (9%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D T+RDG + S ++A+ L++A+VD IEV+ Y Sbjct: 5 SEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVS-----------YPAK 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + D + I A + +K++ + L + I ++ +R R+ + + Sbjct: 54 SQQDFDEIVAVSREIKNSIVCALSNLSVQEIERAATGLKSASRG-RIHLYSNVNLAKKEP 112 Query: 123 IQYARELGMDTVGFLMMSHM-------------TTPENLAKQAKLMEGYGATCIYVVDSG 169 ++ L M G + + + + L + ++ GA I + DS Sbjct: 113 LKRQEALSMIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINIPDSL 172 Query: 170 GAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + ++ + + ++ +H H + + NS+ A+E G +I+ SL G+ Sbjct: 173 GVLLPAEFAQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECSLNGL 232 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR 266 GA GNA L+ I D+ + + + A++LV+ Sbjct: 233 GARKGNANLKSVIKEIDQNPTYKTSVILEKIPPAEELVK 271 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 58/249 (23%), Positives = 103/249 (41%), Gaps = 30/249 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N K + D TLR+G + E +IA+ALDD VD IE+ + S Sbjct: 33 NVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSR----- 87 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG----------ARVVRVAT 111 + EA + AKI T + + D + A + G ++ +R + Sbjct: 88 ------KDCEAICKLGLKAKILTHIR---CHMDDARVAVETGVDGVDVVIGTSKFLRQYS 138 Query: 112 HCTEADVSAQH----IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 H + + A+ I++ + G++ S + +L K ++ G + + D Sbjct: 139 HGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIAD 198 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G N + + R LK+ + + + H H++ +AN+ A+E G ID S+ G+ Sbjct: 199 TVGCANPRQVYELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGARLIDVSVLGI 256 Query: 228 GAGAGNAPL 236 G G PL Sbjct: 257 GERNGITPL 265 >UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA Length = 303 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 63/296 (21%), Positives = 113/296 (38%), Gaps = 50/296 (16%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I +V RDG I+ ++ +I +L++A + IE+ +SF Sbjct: 5 EKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEI--------TSF------ 50 Query: 64 HSDLEWIEAAAD-------VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA 116 + +WI D VK + ++ ++NA +GA V+ V +EA Sbjct: 51 -VNPKWIPQMVDSKEICETCVKKNERKYEVIVLCPNKKGIENAISSGAEVISVVISVSEA 109 Query: 117 DVSAQHIQYARE------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGY 158 A + E L + TV PE +++ + + Sbjct: 110 HNKANVNRTVEESFKELEEMVYKYPNMKFRLDLATVFGCPFGEEIKPERVSELIEKAKKI 169 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 G I + D+ G N + + +K ++ E +H H +G+AN + A++ G Sbjct: 170 GVKEIMLADTVGLGNPVLVEKILKQVKEQVGTENII-LHIHDTRGMGLANMLVALQLGYS 228 Query: 219 RIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGT---DLYALMDAADDLV 265 + S+ G+G AGN E F+ + +G H LY +D D V Sbjct: 229 IFETSIGGLGGCPFAPGAAGNVATEDFVNMLNGMGINHNIHLEKLYHTLDLIDQYV 284 >UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PWR8_9CLOT Length = 303 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/292 (21%), Positives = 116/292 (39%), Gaps = 44/292 (15%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY--G 60 G ++ + +V RDG+ +++ E ++ K L DA + +E+ +SF + Sbjct: 4 GDRIKVVEVGPRDGLQNLKNWIPTEVKIKLIKDLIDAGIKEMEM--------TSFVHPKA 55 Query: 61 FGAHSDLEWI-EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---- 115 D E + +A D + +I T L + + K A+ G R + +E Sbjct: 56 IPQMKDAEAVTKAVIDELNEKEIRTFAL--VPNLVGAKKAYGCGLREITYVISASEKHNL 113 Query: 116 --------------ADVSAQHIQYARELGMDT-VGFLMMSHMTTPE--NLAKQAKLMEGY 158 AD+ A+ L + T G M + NL + A E Sbjct: 114 ANINRTVQQSLEGLADIRAELPDIQIRLDVATAFGCPFMGQVGEDLVINLIRSA---EKI 170 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 G I + D+ G N + + + + E + G+H H +G+AN +AA+E G Sbjct: 171 GINTITLCDTIGIANPKQVYELSQKVSKEFQ-NIPVGLHLHDTRGMGIANYLAAIEAGIS 229 Query: 219 RIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 + S+ G+G AGN E + +++ + DL AL+ + +L Sbjct: 230 VFETSIGGLGGCPFAPGAAGNTATEDLVNMLNEIKVETNIDLNALVSISKEL 281 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/271 (25%), Positives = 107/271 (39%), Gaps = 40/271 (14%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 Y+ D TLRDG A +SL + IA L + IEV G A + Sbjct: 7 YLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEV-------------GIPAMGE 53 Query: 67 LEW--IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT---------- 114 E I A + + +I T G DL+ A ++GA + + Sbjct: 54 CERQHIRAISQLDLDCRILTW---GRAVREDLRAASKSGADGFHFSLPASPLHLRIWKKN 110 Query: 115 EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLM----EGYGATCIYVVDSGG 170 E V + A+E DT + + KL + GA+ + + D+ G Sbjct: 111 ERWVLRTMSELAKE-AADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIADTTG 169 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +N D D F + + + HAH++L + VAN+++A G ++ G+G Sbjct: 170 RLNPIDTLDLFCDITKNASIDLE--FHAHNDLGMAVANTVSAFIGGATCASVTVNGLGER 227 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAA 261 AGNA LE + +H TD+ MDA+ Sbjct: 228 AGNAALEEV-----SMALKHSTDIDIPMDAS 253 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/259 (26%), Positives = 107/259 (41%), Gaps = 36/259 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG A + ++A+ L+ A VD +E G SS S Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEA----GFAASS-------SS 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRV-------ATHCTE- 115 D E I + V+ + +L +G HD++ A +A AR R+ + H E Sbjct: 58 DFEAIRRISCCVRGCVVCSLAR-AVG--HDVRKAAKALEFARHPRIHVFIGSSSLHIEEK 114 Query: 116 --------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 D +A ++ AR D S P L AK GAT + V D Sbjct: 115 LRMHPLDVVDRAAAMVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTD 174 Query: 168 SGG---AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + G +SD+ + +H H+++ L +AN++AA+ + + ++ Sbjct: 175 TVGHGIPEQLSDVAGML-CRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTV 233 Query: 225 AGMGAGAGNAPLEVFIAAA 243 G+G AGNA LE + AA Sbjct: 234 TGIGERAGNAALEEVVVAA 252 >UniRef50_B9K1B8 Alpha-amylase-related protein n=13 Tax=Rhizobium/Agrobacterium group RepID=B9K1B8_AGRVS Length = 1082 Score = 47.0 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 46/149 (30%), Positives = 63/149 (42%), Gaps = 19/149 (12%) Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 R+ F EL + + A +L L + IA V E R D LA + LE Sbjct: 530 RNPFAIFHYELSKKHE----ARLDLKLELQEGIALVREALARADGQLA--------SDLE 577 Query: 238 VFIAAADKLGWQHGTDL------YALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSF 291 IA ++ Q DL +ALMD AD L+ +P+ VD E L G+A Y F Sbjct: 578 QLIAHLEQTSEQQRADLLLQADTFALMDRADARPFRLRSQPLPVDAERLEAGFASWYQLF 637 Query: 292 LRHCETAAARYGLSAVDILVELGKRRMVG 320 R R+G A D++ L R +G Sbjct: 638 PRSQSGDPDRHGTFA-DVIKRLPAIRAMG 665 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/249 (22%), Positives = 104/249 (41%), Gaps = 32/249 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH--------------GDG 51 + I D TLRDG +S + QIA+ L++ VD+IE+ + Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYAKDIDEIIAVSQV 66 Query: 52 LQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVAT 111 ++GS+ G+ I AA ++ A+ +++ + + + + + + Sbjct: 67 IKGSTLCALAGSQET--EINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDKNSILSTLKK 124 Query: 112 HCTEADVSAQHIQY-ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 ++A +Q+ A + + FL + T E+ GA I + DS G Sbjct: 125 QISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIES-----------GAKIISIPDSLG 173 Query: 171 AMNMSDIRDRFRALKAELKPETQ---TGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 D + + L + P+ Q +H H++L V NS+ +E G +I+ ++ G+ Sbjct: 174 VALPEDFYNLLQKLYQNI-PQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGL 232 Query: 228 GAGAGNAPL 236 GA GNA L Sbjct: 233 GARKGNANL 241 >UniRef50_Q46TI7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Ralstonia eutropha JMP134 RepID=Q46TI7_RALEJ Length = 321 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/122 (32%), Positives = 59/122 (48%), Gaps = 6/122 (4%) Query: 142 MTTPENLAKQAKLME---GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHA 198 +T P + A A L E GA I + D+ G + +R +A+ + E G+H Sbjct: 157 LTGPADEAAIACLAETLAAAGADDIVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHL 216 Query: 199 HHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALM 258 + LG+AN++AAVE G + ASL G+G GN E + +G G DL AL+ Sbjct: 217 LNTRGLGLANALAAVEAGMTVVHASLGGLG---GNVVTEDLAFLLESIGIPTGIDLDALI 273 Query: 259 DA 260 A Sbjct: 274 AA 275 >UniRef50_UPI0001C30DEA pyruvate carboxyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C30DEA Length = 310 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 58/130 (44%), Gaps = 13/130 (10%) Query: 152 AKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIA 211 A+ + G + D+ G N +R F AEL + + H H+ G+AN +A Sbjct: 168 ARALHDLGCEEVGFGDTTGMANPVQVRAFFARATAELGEQVELTAHFHNTRGQGLANVLA 227 Query: 212 AVEEGCDRIDASLAGMG---------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA- 261 A++ GC ++S +G GN E ++ ++G + G DL AL+ A+ Sbjct: 228 ALDAGCRSFESSFGELGGCPQSGPTHPATGNIASEDLVSMLHEMGVETGIDLAALIGASR 287 Query: 262 ---DDLVRPL 268 D L RPL Sbjct: 288 AARDVLGRPL 297 >UniRef50_A6LCK8 Carboxylase, putative n=7 Tax=Bacteroidales RepID=A6LCK8_PARD8 Length = 525 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/296 (21%), Positives = 114/296 (38%), Gaps = 39/296 (13%) Query: 4 KKLYISDVTLRDGMH-AIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY-GF 61 +KL I D+TLRDG A + S + ++ DA ++EV G + S Y G Sbjct: 3 RKLLIRDLTLRDGQQSAFATRMSQAQIDRVLPYYKDAGFYAMEV-WGGAVPDSVMRYLGE 61 Query: 62 GAHSDLEWIEAAADVVKHAKIATLL----LPGIGTIHD------LKNAWQAGARVVRVAT 111 LE I+ + +K++ L L G D +N+ ++G ++R+ Sbjct: 62 NPWDRLEIIKEK--IGNSSKLSALSRGRNLFGYNPYPDEIIEGFCRNSIRSGIDIMRIFD 119 Query: 112 HCTEADVSAQHIQYARELGMDT---VGFLMMSH-------------------MTTPENLA 149 + D I+Y ++ G + + + H + T E Sbjct: 120 ALNDVDNVKSTIRYVKKFGGKADCAICYTIDPHHSPVERIKAALHGRPLHKPVFTNEYFL 179 Query: 150 KQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANS 209 +A +E GA I + D G + + + R K LK H H G+A+ Sbjct: 180 NKALQLESLGADMITLKDMSGLIPPARTAELVRLFKKSLK--VPVDFHTHCTPGYGLASV 237 Query: 210 IAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV 265 ++A+ G D +D ++ G +E+ KLG + D+ A+ +L+ Sbjct: 238 VSAIINGVDIVDTNIWNFAGGPAAPAVELVYIFCKKLGIELDLDMDAIAKINKELL 293 >UniRef50_C5BFR7 3-hydroxy-3-methylglutaryl-CoA lyase n=4 Tax=Bacteria RepID=C5BFR7_EDWI9 Length = 314 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 G + + D+ G N + + L+ L P +H H+ + +AN AA+ +G Sbjct: 178 GISRFTLCDTIGVANPRQTVELLQQLRLAL-PGLDPALHMHNTHGMALANIYAAISQGVT 236 Query: 219 RIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 R +++ G+G AGNA E + D++G HG DL L+ D L Sbjct: 237 RFESAAGGLGGCPFAPGAAGNAATEDLVNMLDRMGIAHGVDLGRLLQVVDRL 288 >UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A943_IGNH4 Length = 488 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 107/268 (39%), Gaps = 23/268 (8%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDD-----ARVDSIEVAHGDGLQGSSF-- 57 +++I+D T RDG A R Y++E + ++ K L + ++ + E + Sbjct: 63 EIWITDTTFRDGQQA-REPYTVEQIVRLYKYLHELGGPLGKIKTTEFFLYTEKDKEAVRR 121 Query: 58 --NYGFGAHSDLEWIEAAADVVKHAKIATLLLPGI-GTIHDLKNAWQAGARVVRVATHCT 114 G+ WI A + + K A L GI +I D ++ A +V Sbjct: 122 VKELGYKYPIPTGWIRAKKEELSLVKEAGLEETGILASISDYHIYFKFKASRGKVVEKYL 181 Query: 115 EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC-IYVVDSGG--- 170 A + + ++ + + + P + K KL E YG + D+ G Sbjct: 182 SVVEEALKMDIIPRVHLEDITRANIFEVVVP-FVRKLMKLSERYGLPVKVRYPDTLGVGV 240 Query: 171 ----AMNMSDIRDRFRALKAEL-KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 AM I L+ P H H++ LGVAN+++A G + +L Sbjct: 241 PIVEAMLPRSIPKLTWVLRHVCGVPSEWLEFHGHNDFHLGVANAVSAWLYGAGLNNGTLL 300 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTD 253 G+G AGN P+E + A +L +HG D Sbjct: 301 GIGERAGNVPIEALVFAYAQL--KHGFD 326 >UniRef50_C3WDK2 Pyruvate carboxyltransferase n=6 Tax=Bacteria RepID=C3WDK2_FUSMR Length = 302 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 61/286 (21%), Positives = 116/286 (40%), Gaps = 40/286 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I +V RDG +I+ S E ++I + + ++ V I++ F + Sbjct: 6 RIEIIEVGPRDGFQSIKEFISTEEKKKIIEGIIESGVKKIQLT------------SFVSP 53 Query: 65 SDLEWIEAAADVVKH--AKIATLLLPG-IGTIHDLKNAWQAGAR----VVRVATHCTEAD 117 + ++ A ++ K+ K L + +K A++ G R V+ V+ +A+ Sbjct: 54 KHIPQMQDAEEIAKYFLNKYPELEFSALVPNYRGVKRAYEMGLRNIAYVISVSEGHNKAN 113 Query: 118 VSAQHIQYARELGMDTVGF----LMMSHMTT---P-------ENLAKQAKLMEGYGATCI 163 V+ + EL F + + TT P + + K G I Sbjct: 114 VNRSVDESFVELEKILADFPDINITLDAATTFGCPFDGEVSYDKVDSYVKRAYDLGIRTI 173 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N I D + E + + +H H ++G+ NS A+++G + AS Sbjct: 174 NLCDTIGISNPKQI-DELLTILLEKYKDIEFQVHIHDTRNMGMLNSYIAIKKGIKHVQAS 232 Query: 224 LAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADD 263 L GMG +GN E F+ DK+ + G + L++ A + Sbjct: 233 LGGMGGCPFAPGASGNLSTEDFVYMLDKINIETGINFKKLVNIAKE 278 >UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM Length = 315 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 62/280 (22%), Positives = 110/280 (39%), Gaps = 37/280 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ I +V LRDG+ + ++ E ++ + A IEV G + + Sbjct: 1 MLPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEV--GSFMSPKAVPQM 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 E +E V A IA L ++ A G + V++ + A A Sbjct: 59 ANTDEVYEKLEKVPGVEYRALIANL--------RGVERAIACGCKKVKLNVSASRAHNLA 110 Query: 121 Q--------------HIQYARELGMDTVGFLMMSHMTTPEN---LAKQAKLMEGYGATCI 163 + A+E G++ G + M+ + + + A ++E Y A I Sbjct: 111 NLNRTPEESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKEIPIGAVASIVEAYMAVGI 170 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELK---PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + A M+ + + + A +K P+ +H H+ LG+AN +A ++ G + Sbjct: 171 NEISLSDASGMA-FPPQVQEICAYMKKHYPKNMWWLHFHNTRGLGMANILAGMQSGFTQF 229 Query: 221 DASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDL 254 D+S AG+G AGN E + ++ G G D Sbjct: 230 DSSFAGVGGCPFVPGAAGNVATEDVLNLCEESGIDTGIDF 269 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 4/111 (3%) Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 VVD+ G + + A+K+ + + +H H + LGVANSI + G D + ++ Sbjct: 190 VVDTMGGLAPHTVPYLIDAIKSRIDKPLE--VHFHDDFGLGVANSIMGLAAGADVVHTTI 247 Query: 225 AGMGAGAGNAPLE-VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR 274 + G AGNA E + +A G+ G D Y+ + + L+R D PVR Sbjct: 248 SACGERAGNAAYEHLALALLTMYGYDLGLD-YSKIYSLSKLLRSFIDLPVR 297 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 98/236 (41%), Gaps = 23/236 (9%) Query: 8 ISDVTLRDGMH-AIRHQYSLENVRQIAKALDDARVDSIEVAHGD-GLQGSSFNYGFGAHS 65 I D TLR+G A +S E +IAK L +D IEV H ++ A S Sbjct: 4 IVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVSIEQKQIVREIVA-S 62 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA--------D 117 +L V+ HA+ L I + + W + T T A + Sbjct: 63 NL------CPVIAHARAN---LADIEAVKETSAQWVGIFLGINEETRLTRARWTISKIFN 113 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQA-KLMEGYGATCIYVVDSGGAMNMSD 176 + + YA+ LG+ V + T L K + GA CI D+ G M ++ Sbjct: 114 CIKESVMYAKTLGLK-VRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVGIMEPNE 172 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + LK++ +H H++ L +AN++AA + G +RI +S+ G+G G Sbjct: 173 VTETIEKLKSDFS-TVPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGERCG 227 >UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD Length = 421 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 63/144 (43%), Gaps = 4/144 (2%) Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 S I +A G++ + +TPE L + +GA+ + + D+ G + R Sbjct: 152 STAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPAGTR 211 Query: 179 DRFRA---LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 R L L + H H++ L + N++ A+E G R+ G+G GNAP Sbjct: 212 ALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTGNAP 271 Query: 236 LEVFIAAADKLGWQHGTDLYALMD 259 +E+ + LGW DL L+D Sbjct: 272 VELLLLNLKLLGWID-QDLTRLVD 294 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 103/255 (40%), Gaps = 22/255 (8%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG-- 62 ++ I+D TLRDG ++ QIA AL D VD IEV G G Sbjct: 33 RVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEV--GTPAMGRDEQEAIRRI 90 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIH------DLKNAWQAGARVVRVATHCTEA 116 A + L A ++ + + G+ ++ + A + G + RV T+ Sbjct: 91 AKAGLPLRVIAWCRMRRGDVDDAIASGVSIVNLSAPVSRFQIAAKFGGSLPRVVAAVTDV 150 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 I YAR G++ S T + L + GA D+ G ++ Sbjct: 151 ------IGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLGVLDPIS 204 Query: 177 IRDRFRALK--AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNA 234 IR A++ +L E H H +L L AN++AA+E G ++ G+G AGNA Sbjct: 205 IRAAIEAVRRITDLPIE----FHGHDDLGLATANTLAALEAGASAASVTVNGLGERAGNA 260 Query: 235 PLEVFIAAADKLGWQ 249 PLE A D L Q Sbjct: 261 PLEQIAVALDSLFAQ 275 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/111 (30%), Positives = 56/111 (50%), Gaps = 14/111 (12%) Query: 132 DTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPE 191 DTVG L M ENL K K G +++ A+N S +K+ ++ Sbjct: 212 DTVGILTPKKM---ENLIKDLK--SG--------LETNKAINNSSTLTNQINIKSNMQMP 258 Query: 192 TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 + +H H++ L VANS++A E+G +I ++ G+G AGN L F+++ Sbjct: 259 VLS-VHCHNDFGLAVANSLSAFEQGVSQIHCTVNGIGERAGNTDLAEFVSS 308 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 96/247 (38%), Gaps = 32/247 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVA---------------HG 49 ++++ D TLRDG +S E +A ALD V+ IE G Sbjct: 3 QVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMGVDEQKAVRAVLG 62 Query: 50 DGLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV 109 GL+ + SD+E A + A + P + IH Q R Sbjct: 63 AGLRARVLAWNRAHPSDIE-----ASLACGATCLQISFP-VSDIH-----LQHKLGRTRS 111 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +V A + RE+ + + P L AK E GA + D+ Sbjct: 112 WLLARLEEVMALAVAPGREVAVGAED----ASRADPAFLRLFAKKAEEAGACRLRYCDTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G ++ RD L +L + HAH++ + AN++AAV+ G +D ++ G+G Sbjct: 168 GVLDPFRSRDAVSDLTHKLNIPLE--FHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGE 225 Query: 230 GAGNAPL 236 AGNA L Sbjct: 226 RAGNASL 232 >UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. Mg1 RepID=B4VB43_9ACTO Length = 474 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 46/93 (49%) Query: 148 LAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVA 207 +A A+ M G GA + + D+ GA S + FR ++AE E H H++L LG+A Sbjct: 208 MAHYARAMTGAGAGLVVLADTVGAQLPSGCAEMFRRVRAEAGSEVVLASHLHNDLGLGLA 267 Query: 208 NSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 N++ A+ G +S G+ AG E + Sbjct: 268 NTLEALAAGVRVASSSWLGIAERAGMVATEQLL 300 >UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=Q1IW44_DEIGD Length = 436 Score = 45.4 bits (106), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/56 (46%), Positives = 31/56 (55%) Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 R L A P Q H H++ L VAN +AAV GC I+ +L G G GNAPLE Sbjct: 239 RELVAAGVPGEQLEFHPHNDTHLVVANCLAAVIAGCAAINGTLLGKGERTGNAPLE 294 >UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MJY3_9BACT Length = 405 Score = 45.1 bits (105), Expect = 0.004, Method: Compositional matrix adjust. Identities = 19/47 (40%), Positives = 32/47 (68%) Query: 196 MHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +H H++L L VANS+ A+E+G +++ ++ G+G AGN LE + A Sbjct: 100 VHCHNDLGLAVANSLIAIEQGARQVECTINGLGERAGNTSLEEVVMA 146 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 45.1 bits (105), Expect = 0.004, Method: Compositional matrix adjust. Identities = 67/294 (22%), Positives = 114/294 (38%), Gaps = 44/294 (14%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K I D TLR+G +++ E+ +I L+ +++ IEV H G A Sbjct: 2 KPFQILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHP----------GISA 51 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA--- 120 + E V + A+ A +L+ T+ ++ A +A A V + + + Sbjct: 52 LDE----EICRKVAQSARRAQILMHARATVEEVHAAKRAKADWVGIWASINDVSIQTKFR 107 Query: 121 ------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 Q + A++LG+ + + T E ++ GA I + D+ Sbjct: 108 HHEESYILEKVQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + E E + +H H++ L AN++AA++ G IDA++ G+G Sbjct: 168 VGIWEPDTCKKIVTRAIEEFGCEIE--VHLHNDFGLAQANALAAIDAGASVIDATILGIG 225 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV---------RPLQDRPV 273 AG L A KL H L D +LV RP + RP+ Sbjct: 226 ERAGITDLIQLTVALQKLRNDHRYSL----DRIPELVQAIRLTTGYRPDELRPI 275 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 45.1 bits (105), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 7/129 (5%) Query: 145 PENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSL 204 P+ L K A++ + GA + + D+ G ++ R + E + HAH +L L Sbjct: 172 PDFLCKVAEVAKEAGAFRLRLADTLGVLDPFSAYALVRRVANATDLEIE--FHAHDDLGL 229 Query: 205 GVANSIAAVEEGCDRIDASLAGMGAGAGNAPL-EVFIAAADKLGWQHGTDLYALMDAADD 263 AN++AAV G ++AG+G AGNA L EV IA + G D +AL A Sbjct: 230 ATANTLAAVTGGARHASVTVAGLGERAGNAALEEVAIALRQTARSETGIDPHALRPLAQK 289 Query: 264 LV----RPL 268 ++ RP+ Sbjct: 290 VMEAAGRPM 298 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 106/267 (39%), Gaps = 56/267 (20%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV---AHGDG----------- 51 + I+D TLRDG + + +IA+AL +A V +E A G+ Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQ 77 Query: 52 ---------LQGSSFNYGFGAHSDLEWIE---AAADVVKHAKIATLLLPGIGTIHDLKNA 99 + +S A ++W++ A+D+++ K+ P I LK Sbjct: 78 LPDTVMMSWCRMNSAEIHDSARVGMDWVDISVPASDLLREQKLHR---PWPAVIASLKPL 134 Query: 100 WQAGARV-VRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY 158 Q R+ +RV C +A SA E L A++ Sbjct: 135 VQLAHRLGMRVCMGCEDASRSAD------------------------ETLHMLAEVAADL 170 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 G + D+ G ++ R AL+ + +HAH++L + AN++AAV G Sbjct: 171 GIERMRFADTLGILDPFSTFTRISALRQHWHGGLE--IHAHNDLGMATANTLAAVRAGAT 228 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAADK 245 ++ ++ G+G AGNA LE + D+ Sbjct: 229 HVNTTVLGLGERAGNAALESVTLSLDR 255 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 44.7 bits (104), Expect = 0.005, Method: Compositional matrix adjust. Identities = 28/80 (35%), Positives = 43/80 (53%), Gaps = 4/80 (5%) Query: 159 GATCIYVVDSGGAMNMSDIRDRF-RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 G T + D+ G ++ DR R ++A P +HAH + L AN+IAAV+ G Sbjct: 175 GVTRLRWADTVGLLDPVSAYDRLGRLVRAVPGPWE---IHAHDDFGLATANTIAAVQAGF 231 Query: 218 DRIDASLAGMGAGAGNAPLE 237 + ++ G+G AGNAP+E Sbjct: 232 TWVSTTVLGLGERAGNAPIE 251 >UniRef50_A8RV44 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RV44_9CLOT Length = 533 Score = 44.7 bits (104), Expect = 0.005, Method: Compositional matrix adjust. Identities = 68/312 (21%), Positives = 126/312 (40%), Gaps = 51/312 (16%) Query: 28 NVRQIAKALDDARVDSIE---VAHGDGLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIAT 84 N+ ++ L+ A VD IE + + D ++GS+ + +E +K+ K Sbjct: 25 NIHKMIHGLEMANVDIIECGFLKNADYIKGST---------SFQRVEDIIPFLKNKKKGK 75 Query: 85 LLLPGIGT-IHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELG----------MDT 133 + + +DLK + R + C + + + YA ++ +DT Sbjct: 76 TYVALVDYGRYDLKYLSEYDRRSIDAIRVCFKKNEIGLVLDYAAQIRAKGYQVCVQHVDT 135 Query: 134 VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQ 193 +GF E + + + + VVD+ GAM D+ L + Sbjct: 136 MGFF-------DEEIIDFIEKVNEFKPLAYSVVDTFGAMYEEDMLHYTGLADQYLSKDIL 188 Query: 194 TGMHAHHNLSLGVANSIAAVEEGCDR----IDASLAGMGAGAGNAPLEVFIAAADKLGWQ 249 G HAH+NL L AN+ + + + +DASL G G AGNA E+ +K + Sbjct: 189 LGFHAHNNLMLADANAQSYINKMSAHRDVVVDASLFGCGRSAGNAHTELIAQFINK-KHE 247 Query: 250 HGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY------AGVYSSFLRHCETAAARYG 303 ++ L+D D ++ Q E + GY AG+Y++ + + R+ Sbjct: 248 EKYNIDELLDLIDTVIASAQ--------EVTSWGYSIPYFIAGIYNAHTFNVKQLLKRHN 299 Query: 304 LSAVDI--LVEL 313 + + D+ ++EL Sbjct: 300 IKSKDLRGIIEL 311 >UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystineae RepID=D0LGL9_HALO1 Length = 424 Score = 44.7 bits (104), Expect = 0.005, Method: Compositional matrix adjust. Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 16/162 (9%) Query: 81 KIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA-DVSAQHIQYARELGMDTVGFLMM 139 +I L G I +W + R+ +EA D++A+H + DT Sbjct: 125 EIEVLTFIGSSPIRQYAESWD----LERMLNFSSEAIDLAARHNLPVTFVTEDTT----- 175 Query: 140 SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR----ALKAELKPETQTG 195 + PE L + + +GA + + D+ G I + R L+A +P+ Sbjct: 176 --RSRPEVLDQMFRNAIEHGANRLCLCDTVGHSTPDGIHNLIRFTRNLLEAMGRPDVGID 233 Query: 196 MHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 H H++ LGV N+I A+E G R+ + G+G GNA L+ Sbjct: 234 WHGHNDRGLGVVNTIFAIEYGASRVHGTAMGLGERVGNAALD 275 >UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB Length = 456 Score = 44.7 bits (104), Expect = 0.005, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 99/239 (41%), Gaps = 29/239 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D +LR+G I+ + +E +A+ + + VD IE H + S + +L Sbjct: 5 IIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHP---KISPY--------EL 53 Query: 68 EWIEAAA-----DVVKHAKIATLLLPGIGTIHDLKNAWQ---AGARVVRVATHC------ 113 E + A V+ HA+ + I + + AW A V +AT Sbjct: 54 ERVRAVVRVSPLPVLAHARCRS---EDIDAVAESGAAWVGMFASFNPVSLATKFGGMGKD 110 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + I+YA+ G+ + + T +L + + GA I DS GA+ Sbjct: 111 QVLALFEASIRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGALL 170 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 S+ D L+ E + + Q H H++ L +A+S+ A+ G + I S G+G AG Sbjct: 171 PSETYDILALLRHEFR-QVQFEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAG 228 >UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces RepID=D1WUS8_9ACTO Length = 359 Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust. Identities = 21/45 (46%), Positives = 30/45 (66%) Query: 192 TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 ++ +H+H+ L L VANS+AAV G I A++ G+G GNAPL Sbjct: 179 SEIEIHSHNMLGLAVANSLAAVRAGARWISATVGGIGERGGNAPL 223 >UniRef50_B1G528 Pyruvate carboxyltransferase n=2 Tax=Proteobacteria RepID=B1G528_9BURK Length = 319 Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust. Identities = 78/331 (23%), Positives = 129/331 (38%), Gaps = 52/331 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYS----LENVRQIAKA--------------LDDARVDSIE 45 +K+ + +V LRDG+ +R S LE R++ +A + D++E Sbjct: 5 EKVTVREVGLRDGLQMVRTILSTEQKLEWCRRMVEAGSVEIEVTSFVPPKIVPQFADAVE 64 Query: 46 VAHG----DGLQGSSFNYGF-GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW 100 VA G GL ++ GA E V +K+ +L H+LKN Sbjct: 65 VARGALDITGLHAAALVPNLKGAQRAFE--------VGLSKVHYVL--SASNEHNLKNVR 114 Query: 101 QAGARVV----RVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLME 156 + A V R+ + +A+ I G+ T +S + + + Sbjct: 115 RTTAESVEDFARIVLERDTVERTARRITLG--AGVATAFGCTISGRVEESGVLGLVETLL 172 Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GA I + D+ G N ++ R + A + + H H LG+AN +AA++ G Sbjct: 173 EAGADEITIADTVGYANPRQVKALMREVLA-ITRDVPVACHFHDTRGLGLANVVAALDAG 231 Query: 217 CDRIDASLAGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 D+SL G+G GN E + + G+ G ++ AL+ + + L Sbjct: 232 VRSFDSSLGGLGGCPFAPNATGNINTEDTVFLLESEGFDTGINIDALLAIRETIAGWLPG 291 Query: 271 RPVRVDRETLALGYAGVYSSF-LRHCETAAA 300 P T A+ AGV +F LR E A Sbjct: 292 EPF-----TGAIARAGVPKTFDLREAEMLPA 317 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 99/250 (39%), Gaps = 28/250 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEV------AHGDGLQG 54 M + I DVTLRDG ++ + + IA LD ++ IE AH + Sbjct: 1 MKPWHIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEKEMVR 60 Query: 55 SSFNYGFGA------HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVV 107 + G A + E ++AA D + I + P DL ++ R V Sbjct: 61 NISRLGLSAKICGLSRACREDVDAALDA-EVDMIGLFIAPS-----DLHLKYKHKKPRDV 114 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 VA + D + H R D + T P+ L + + AT + D Sbjct: 115 VVANALEQLDYAVDHGLIVRFGAED-------ASRTDPDILVDIYRQAADHKATYVTYAD 167 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + ++ + L K MHAH++L AN++ A E G ++ ++ G+ Sbjct: 168 TTGCLTPLEVATVMKDLVP--KTPIPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNGL 225 Query: 228 GAGAGNAPLE 237 G AGNA LE Sbjct: 226 GERAGNARLE 235 >UniRef50_B8IFJ3 Pyruvate carboxyltransferase n=3 Tax=Alphaproteobacteria RepID=B8IFJ3_METNO Length = 313 Score = 44.3 bits (103), Expect = 0.007, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 43/96 (44%), Gaps = 13/96 (13%) Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG----- 228 S+ RF +KA +HAH LG+AN AA EG DAS AG+G Sbjct: 198 FSEAPSRFPEVKA-------WALHAHDTYGLGLANVHAAYREGVRIFDASFAGLGGCPFA 250 Query: 229 -AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADD 263 GN E + +++G G DL AL+ A D Sbjct: 251 PGATGNVATEDLVWMFERMGVATGVDLAALVSVARD 286 >UniRef50_C4JI85 Pyruvate carboxylase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JI85_UNCRE Length = 1131 Score = 43.9 bits (102), Expect = 0.007, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 93/241 (38%), Gaps = 37/241 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K I+D T RDG Q SL R +K LD +Y + A Sbjct: 544 RKTLITDTTWRDG------QQSLLATRVRSKDLDAI--------------AKHVSYAYQA 583 Query: 64 HSDLE-WIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 LE W A DV + LLP H +K A G + RV + + Sbjct: 584 AYSLECWGGATFDV-----MLRFLLPDNALFHFVKLAKDTGVDIFRVFDSLNDLENLKVG 638 Query: 123 IQYARELGMDTVGFLMMS-HMTTPEN-------LAKQAKLMEGYGATCIYVVDSGGAMNM 174 I+ G G +M + M P N L +L+E YG+ I + G M Sbjct: 639 IEAVHAAGGLVEGAVMYTGDMLEPGNKYNLEYYLGIVDRLVE-YGSHVIAIKSMSGVMKP 697 Query: 175 SDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNA 234 + R +A++ P+ MH H G A +A VEEG D +D ++ + +G+ + Sbjct: 698 AAGRALVKAIRLRY-PDIPIHMHTHDTNGTGTATMLACVEEGADIVDTAIDSL-SGSTSQ 755 Query: 235 P 235 P Sbjct: 756 P 756 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust. Identities = 63/260 (24%), Positives = 105/260 (40%), Gaps = 31/260 (11%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIE---VAHGDGLQGSSFNYGFGAHSD 66 D TLR+G ++LE ++IA +L VD IE V D + + G + Sbjct: 4 DTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGWVGQDDLALFAGYARTLGGDTA 63 Query: 67 LE-W-------IEAAADV-VKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD 117 L W IE AA++ +K I +P + +H K ++R Sbjct: 64 LSVWSPCREKDIEVAAELGLKRINIG---VP-VSDLHIEKRLDSDRQAILRKL------- 112 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKL-MEGYGATCIYVVDSGGAMNMSD 176 A ++ A++ G + V + + A L E GA+ + + DS G + Sbjct: 113 --AAAVRTAKDCGFEYVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQLTPLA 170 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 + R + +L +H H + + ANS A+E G D D S+ G+G +G A Sbjct: 171 MEKLVRKFREKL--HIDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSGIAAT 228 Query: 237 EVFIAAADKLGWQHGTDLYA 256 E +A +L + G Y+ Sbjct: 229 EELVA---RLALREGNTRYS 245 >UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria RepID=A8ZRW8_DESOH Length = 681 Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust. Identities = 66/283 (23%), Positives = 112/283 (39%), Gaps = 34/283 (12%) Query: 6 LYISDVTLRDG---MHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN--YG 60 L I D++LRDG + A R + E++ +A +D+ ++EV G++F+ + Sbjct: 25 LKIMDLSLRDGHQSLFATRGR--TEDMLPVAGLMDEVGFWAVEV-----WGGATFDTMHR 77 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLL----LPGIGTIHD------LKNAWQAGARVVRVA 110 F E I K ++ LL L G D ++ A + G V R Sbjct: 78 FLNEDPWERIRTLKRYFKKTPLSMLLRGQNLVGYRNYADDVARAFVERAAENGMDVFRTF 137 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTP---------ENLAKQAKLMEGYGAT 161 + ++ ++ G G + S MT P E +AK +E GA Sbjct: 138 DALNDFRNFETVVEVIKKCGKHFQGTICYS-MTEPRLGGEVYNVEYFVTKAKELESMGAD 196 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 I + D G + DI + +ALK +KP H+H L + + AVE G D +D Sbjct: 197 TICIKDMAGLVAPYDIFNVVKALKESVKPPIH--FHSHFTSGLAPMSHLKAVEAGVDILD 254 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 L+ + +E + + G D+ L++ + L Sbjct: 255 TCLSPYAYRTSHPAVEPMVMSLLGTNRDTGFDINKLVEITEIL 297 >UniRef50_B9LMV8 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LMV8_HALLT Length = 314 Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust. Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 53/286 (18%) Query: 7 YISDVTL-----RDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 Y SDVTL RDG + + +I AL + VD IE+ +SF + Sbjct: 4 YPSDVTLVEMLPRDGFQRLDEFVPTDEKVEIIDALSETGVDEIEI--------TSFTHPK 55 Query: 62 GAHSDLEWIEAAADVVKHAKIA--TLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 + + E A + +H + L+ +G ++ A AG V +V T ++ Sbjct: 56 AVPTLRDADEVAQRIERHDDVTYRALVPNAVG----MERAIDAG--VDKVNALVTVSETY 109 Query: 120 AQHIQ--YAREL--GMDTV-------GFLMMSHMTTPENLAKQAKL-MEGYGATCIYVVD 167 ++H Q E+ G++ + G + + M T + ++ ME + VVD Sbjct: 110 SEHNQNMTVEEILTGVEEIVEMAEGTGIEVEAGMGTSFYCPYEGRIPMEDTLSVVDRVVD 169 Query: 168 SG----------GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 +G G + +I + + + + P+ G+H H + +AN++ A++ G Sbjct: 170 AGVDEVTLATTMGLADPVEIEEMYTTV-FDRHPDLDAGLHLHDTNGMSLANTLVAMQCGV 228 Query: 218 DRIDASLAGMG---------AGAGNAPLEVFIAAADKLGWQHGTDL 254 DR DAS G+G G GN P E + ++ + D Sbjct: 229 DRFDASHCGLGGGVVLPDGLGGVGNTPTEDLVQMLTRMDLETNADF 274 >UniRef50_Q3IQK7 Homolog to 2-isopropylmalate synthase, homocitrate synthase n=1 Tax=Natronomonas pharaonis DSM 2160 RepID=Q3IQK7_NATPD Length = 296 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 22/49 (44%), Positives = 31/49 (63%) Query: 192 TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 T+ G+ ++ G AN+I A E G DR+DAS+AG+GA AG A E + Sbjct: 182 TRAGVRFRDDVGCGTANAIVAAETGIDRVDASVAGVGARAGLAATEELV 230 >UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT Length = 532 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 62/260 (23%), Positives = 105/260 (40%), Gaps = 46/260 (17%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKAL-DDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I D TLRDG + IA+ L D VD IEVA +G Sbjct: 13 KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMLLHDINVDRIEVASARVSEGEK------ 66 Query: 63 AHSDLEWIEAAADVVKHAKIATLL--LPGIGTIHDLKNA-W--QAGARVVRVA-----TH 112 +A A + ++AK L + +G + + K+ W + G V+ + H Sbjct: 67 --------DAVARICRYAKTIGKLDSVEVLGFVDNNKSVDWIAECGGHVINLLAKGSYKH 118 Query: 113 CTE--ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAK-----------LMEGYG 159 CT+ +H+ + ++ T+G+ + T L + +M+ Sbjct: 119 CTQQLKMSPEEHLAHIKQ----TIGYALSKGFTVNLYLEDWSSGMRDSRDYLFMMMDELV 174 Query: 160 ATCI---YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 I + D+ G +N + R + P + HAH++ L V+NS+AAV G Sbjct: 175 KQPIKRFLLPDTLGILNPLQCVEYMRQM-VRRYPNSHFDFHAHNDYDLAVSNSLAAVLSG 233 Query: 217 CDRIDASLAGMGAGAGNAPL 236 + ++ G+G GNAPL Sbjct: 234 AKGLHVTVNGLGERCGNAPL 253 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 115/277 (41%), Gaps = 46/277 (16%) Query: 2 NG-KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 NG +++ I D TLRDG + E+ +IA+ALD+ V IE G GS+ Sbjct: 27 NGERRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIE----GGWPGSN---- 78 Query: 61 FGAHSDLEWIEAAA-DVVKHAKIAT------------------LLL----PGIGTIHDLK 97 D+ + E A +HA+I LLL P + TI Sbjct: 79 ---PKDMAFFERARHQQWRHARITAFGSTRRAGGTVEEDVNLRLLLEAETPAV-TIVGKA 134 Query: 98 NAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKL 154 + +Q RV+ T + A+ + + + G + + + P+ + Sbjct: 135 SPFQV--RVILGTTLDENLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALAVLRA 192 Query: 155 MEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQT-GMHAHHNLSLGVANSIAAV 213 GA + + D+ G + RA++ L + T G+H H++ L VAN+IAAV Sbjct: 193 ACDAGADAVVLCDTNGGTLTDPL---VRAVRHALSSVSCTVGIHTHNDCELAVANTIAAV 249 Query: 214 EEGCDRIDASLAGMGAGAGNAPLEVFIAAAD-KLGWQ 249 G + ++ G+G GNA L I + KLG++ Sbjct: 250 LAGAMHVQGTMNGLGERIGNANLCSIIPILEYKLGYR 286 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 91/305 (29%), Positives = 127/305 (41%), Gaps = 53/305 (17%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 +L++ D TLRDG A +S + IA+AL +ARV +EV G+ + G GA Sbjct: 8 RLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEV----GIPAA----GAGAI 59 Query: 65 SDLEWIEAAADVVK-HAKIATLL--LPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 D I A AD V A+I T LPG D+ A AR RV VS Sbjct: 60 DD---INAVADAVAGRARIITWCRALPG-----DI-----ALARACRVTGVHLSFPVSNI 106 Query: 122 HIQY------------------ARE-LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 H++ ARE TVG S P LA+ A A Sbjct: 107 HMRIWGATPATVLASLDELTAAAREHFDQVTVGAQDASR-ADPGFLAEFAAAAARTPAVR 165 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK---PETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + + D+ G + D+ L + L+ P +HAH++L L AN++AA G Sbjct: 166 LRLADTVGFLTP----DKTAGLTSHLRHAAPALPVEIHAHNDLGLATANTLAAFSAGASA 221 Query: 220 IDASLAGMGAGAGNAPL-EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRE 278 ++ G+G AGNA L EV +A G G D ++ + LV RPV V + Sbjct: 222 ASLTVNGLGERAGNAALEEVVMALKVAQGIDCGIDTSRFVELS-ALVARASRRPVPVQKP 280 Query: 279 TLALG 283 + G Sbjct: 281 VVGAG 285 >UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK Length = 338 Score = 43.5 bits (101), Expect = 0.010, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 112/290 (38%), Gaps = 48/290 (16%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG-- 60 G+ ++I+DV +RDG+ +E V + + A +D I + ++ +SF Sbjct: 9 GESVWINDVVMRDGLQ-------MEPV-FVPTSEKVALIDEIGHCGLNRIEATSFTSAKA 60 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGT-------------------IHDLKNAWQ 101 A SD E + + V + A L+L G H+L N Sbjct: 61 IPALSDAEAVMHEIERVPGVRYAALVLNRRGAERALECGVDELNLGVSASETHNLANTRM 120 Query: 102 AGARVVR----VATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEG 157 A+ VR + C D A + A G G + + + N A Sbjct: 121 TRAQAVRALLDITAFCR--DRLAIGVSIATAFGCPMEGAIDIDSVLDIGNQFVAA----- 173 Query: 158 YGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 G I + D+ G N ++ AL A + T +H H+ +G+AN +A ++ G Sbjct: 174 -GVRGITLCDTTGMANPRQVKAVCGALAARWRGIELT-LHLHNTRGMGLANVVAGLDAGI 231 Query: 218 DRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA 261 DASL G+G +GN E + D +G+ G DL L+ A Sbjct: 232 RHFDASLGGLGGCPFAPGASGNICTEDLVHMLDAMGYATGVDLERLIACA 281 >UniRef50_B2V325 Pyruvate carboxylase n=9 Tax=Clostridiales RepID=B2V325_CLOBA Length = 1146 Score = 43.5 bits (101), Expect = 0.010, Method: Composition-based stats. Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 4/123 (3%) Query: 151 QAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSI 210 +AK +E GA + + D + + ALK E+ +H H GVA + Sbjct: 692 KAKEIEKMGAHILAIKDMSALLKPYAAKKLITALKNEVSIPIH--LHTHDTTGNGVATVL 749 Query: 211 AAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD--DLVRPL 268 A + G D ID + M L +AA + G D+ + +D D VRP+ Sbjct: 750 MAADAGVDIIDTTFNSMSGLTSQPALNSIVAALNNTDRDTGIDIRGIQKLSDYWDAVRPV 809 Query: 269 QDR 271 D+ Sbjct: 810 YDQ 812 >UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT Length = 399 Score = 43.5 bits (101), Expect = 0.011, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 98/256 (38%), Gaps = 45/256 (17%) Query: 4 KKLY-ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK++ + D TLR+G SLE + I L +D +E G Sbjct: 29 KKVFMLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETG------------SVG 76 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +LE + A +H + L I +L+ A ++ A VS H Sbjct: 77 RDEELETLIKYAR--QHHGSTKISLWSPCRIQELEYADSLDPDIISAAL-----PVSDLH 129 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY---------------------GAT 161 I+ + LG+D G L + T +AKL G G Sbjct: 130 IE--KRLGLDRCGALRLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVW 187 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + + D+ G M ++ + R + +L + H H++ + AN++ A+ G D +D Sbjct: 188 RVRLSDTLGVMEPGELMEAVRPFREKL--DISLAFHGHNDFGMATANALTALSCGVDYVD 245 Query: 222 ASLAGMGAGAGNAPLE 237 SL G+G AG A LE Sbjct: 246 VSLLGIGERAGIARLE 261 >UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD Length = 389 Score = 43.5 bits (101), Expect = 0.012, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 8/133 (6%) Query: 149 AKQAKLMEGYGATC------IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNL 202 +++A LM Y A + + D+ G + R ++ + E H H++ Sbjct: 154 SEEADLMAVYRAVSDLGVHRVGLADTVGVATPRQVYTLVREVRKVIHAECGIEFHGHNDT 213 Query: 203 SLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLY--ALMDA 260 V+N+ A+E G ID ++ G+G G PL F+A Q D Y L+ Sbjct: 214 GCAVSNAYEAIEAGATHIDTTILGIGERNGITPLGGFLARMFTFDPQGLIDKYNLELLPE 273 Query: 261 ADDLVRPLQDRPV 273 D L+ L D P+ Sbjct: 274 LDRLIARLVDLPI 286 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 43.5 bits (101), Expect = 0.012, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 3/88 (3%) Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 GA I D+ G + + +R L P +H H++ L VANS+A + G Sbjct: 156 GAERICACDTVGILTPERSYEFYRGLSELGAP---LSVHCHNDFGLAVANSLAGLRAGAS 212 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAADKL 246 + A++ G+G AGNA LE + A L Sbjct: 213 EVHATINGIGERAGNAALEEVVVALKSL 240 >UniRef50_Q2F685 Hydroxymethylglutaryl-CoA lyase isoform 1 n=2 Tax=Bombyx mori RepID=Q2F685_BOMMO Length = 338 Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 66/147 (44%), Gaps = 13/147 (8%) Query: 145 PENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSL 204 P+N+AK + G + + D+ G +R + KPE Q +H H Sbjct: 179 PKNIAKITEQWIAMGCYEVSLGDTMGVGTAGSVRRLLHEILTVAKPE-QLALHFHDTYGQ 237 Query: 205 GVANSIAAVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALM 258 G++N +A +E G +D+S++G+G +GN E + LG DL ++ Sbjct: 238 GLSNLLAGLELGIKTVDSSISGLGGCPYARGASGNLATEDLVYFLYGLGVNTDVDLVKII 297 Query: 259 DA----ADDLVRPLQDRPVRV--DRET 279 +A ++ L +P + + RV DR T Sbjct: 298 EAGRYISNFLGKPTESKVNRVISDRFT 324 >UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN Length = 325 Score = 43.1 bits (100), Expect = 0.013, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 61/134 (45%), Gaps = 7/134 (5%) Query: 144 TPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLS 203 +P +A+ K G I + D+ G ++D A+ E+ P +H H Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEV-PLAALAVHCHDTYG 239 Query: 204 LGVANSIAAVEEGCDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYAL 257 +AN++ A++ G +D+S+AG+G +GN E + + LG G +L L Sbjct: 240 QALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKL 299 Query: 258 MDAADDLVRPLQDR 271 ++A + + + L + Sbjct: 300 LEAGNFICQALNRK 313 >UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ2_9SYNE Length = 411 Score = 43.1 bits (100), Expect = 0.014, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 38/79 (48%), Gaps = 1/79 (1%) Query: 195 GMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE-VFIAAADKLGWQHGTD 253 +H H+++ L + N+I AV G I + G+G AGNAP+E V + GW+ Sbjct: 213 SVHFHNDMGLALENTIQAVCAGARGISGTFGGIGERAGNAPIEQVLKGLRSRFGWEVAGI 272 Query: 254 LYALMDAADDLVRPLQDRP 272 Y +D D + RP Sbjct: 273 DYDALDQVVDYLHAQGHRP 291 >UniRef50_Q8ELJ7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Oceanobacillus iheyensis RepID=Q8ELJ7_OCEIH Length = 318 Score = 43.1 bits (100), Expect = 0.014, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D+ G + + LK E P MH H+ + +AN+I+A+++G R D+ Sbjct: 179 VSLADTTGMATPKQVYETLGVLK-ETYPTLTFSMHFHNTRGMALANTISALQQGVIRFDS 237 Query: 223 SLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 S+AG+G +GN E + + G G +L +++ A ++ Sbjct: 238 SIAGLGGCPYAPGASGNVATEDLVHFLHENGVDTGINLSSVITTAKEV 285 >UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT Length = 554 Score = 43.1 bits (100), Expect = 0.014, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 73/165 (44%), Gaps = 11/165 (6%) Query: 104 ARVVRVATHCTEADVSAQHIQYARELGMDT---VGFLMMSHMTTPENLAKQAKLMEGYGA 160 A V + ++ S +++++ E DT + H+ A K++ A Sbjct: 148 ATVQSIKEEASKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWQPAADEKVILNLPA 207 Query: 161 TCIYVVDSGGAMNMSDIRDRF-RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 T V+ + +D+ + F R LK+E + +HAH+++ VA++ A++ G R Sbjct: 208 T----VERRPPTHYADMIELFQRKLKSE---QAIISLHAHNDMGCAVASTQLAIQAGAHR 260 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 ++ +L G G +GN L + LG G D LM+ + + Sbjct: 261 VEGTLFGQGERSGNVDLITLVLNLQYLGIDTGLDFSDLMNITEQI 305 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteri... 363 6e-99 UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bac... 360 3e-98 UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Prot... 352 1e-95 UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacte... 349 8e-95 UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocar... 346 7e-94 UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfi... 343 4e-93 UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bact... 338 1e-91 UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseud... 333 7e-90 UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta pr... 316 8e-85 UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea Rep... 306 9e-82 UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodoco... 300 4e-80 UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseob... 299 1e-79 UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkho... 295 2e-78 UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio ... 294 4e-78 UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellul... 293 6e-78 UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octade... 286 6e-76 UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salin... 283 5e-75 UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimon... 279 1e-73 UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ... 276 9e-73 UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=... 250 5e-65 UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=M... 248 2e-64 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 246 1e-63 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 245 1e-63 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 241 2e-62 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 240 6e-62 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 238 2e-61 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 237 3e-61 UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 236 6e-61 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 236 6e-61 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 236 1e-60 UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 236 1e-60 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 234 3e-60 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 234 3e-60 UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Ta... 232 9e-60 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 232 9e-60 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 232 1e-59 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 231 4e-59 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 229 9e-59 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 229 9e-59 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 229 1e-58 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 228 2e-58 UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 228 3e-58 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 228 3e-58 UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geob... 227 5e-58 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 227 6e-58 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 227 6e-58 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 226 1e-57 UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacter... 225 2e-57 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 225 2e-57 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 224 3e-57 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 224 3e-57 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 224 5e-57 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 224 5e-57 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 223 8e-57 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 222 9e-57 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 222 2e-56 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 222 2e-56 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 221 2e-56 UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q... 221 3e-56 UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria Re... 221 3e-56 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 221 3e-56 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 220 5e-56 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 219 9e-56 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 219 1e-55 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 218 2e-55 UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 T... 218 3e-55 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 217 3e-55 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 217 5e-55 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 216 7e-55 UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C... 216 7e-55 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 216 9e-55 UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legione... 216 1e-54 UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 216 1e-54 UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 214 2e-54 UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synech... 214 3e-54 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 214 4e-54 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 214 5e-54 UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria Re... 213 6e-54 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 212 1e-53 UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostri... 212 1e-53 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 211 2e-53 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 211 4e-53 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 210 6e-53 UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legione... 210 6e-53 UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacte... 209 1e-52 UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides... 207 3e-52 UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostri... 207 5e-52 UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax... 206 7e-52 UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter l... 206 8e-52 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 206 9e-52 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 206 9e-52 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 205 2e-51 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 205 2e-51 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 204 4e-51 UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=... 204 6e-51 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 203 6e-51 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 203 6e-51 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 203 7e-51 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 203 9e-51 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 202 1e-50 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 202 1e-50 UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenom... 202 2e-50 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 202 2e-50 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 202 2e-50 UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryante... 202 2e-50 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 201 3e-50 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 201 4e-50 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 201 5e-50 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 200 7e-50 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 200 7e-50 UniRef50_C4Z863 HMGL family protein n=4 Tax=Bacteria RepID=C4Z86... 199 2e-49 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 198 2e-49 UniRef50_Q4HR83 4-hydroxy-2-ketovalerate aldolase, putative n=2 ... 197 3e-49 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 197 3e-49 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 197 4e-49 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 197 5e-49 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 197 6e-49 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 196 8e-49 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 196 8e-49 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 195 2e-48 UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteri... 195 2e-48 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 195 2e-48 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 194 3e-48 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 194 3e-48 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 194 3e-48 UniRef50_C4Z4L3 Putative uncharacterized protein n=1 Tax=Eubacte... 194 3e-48 UniRef50_Q24S97 Putative uncharacterized protein n=1 Tax=Desulfi... 194 5e-48 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 193 7e-48 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 191 3e-47 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 191 3e-47 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 189 9e-47 UniRef50_B3QVI9 Pyruvate carboxyltransferase n=5 Tax=Bacteroidet... 189 1e-46 UniRef50_A7VV06 Putative uncharacterized protein n=1 Tax=Clostri... 189 1e-46 UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia... 188 3e-46 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 187 4e-46 UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, s... 187 4e-46 UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece ... 187 4e-46 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 187 5e-46 UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curviba... 187 5e-46 UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyr... 187 6e-46 UniRef50_A2U042 HMGL-like protein n=1 Tax=Polaribacter sp. MED15... 187 6e-46 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 187 7e-46 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 186 8e-46 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 185 2e-45 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 185 2e-45 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 184 3e-45 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 183 7e-45 UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase ... 183 9e-45 UniRef50_Q12KS9 Pyruvate carboxyltransferase n=2 Tax=Gammaproteo... 183 1e-44 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 183 1e-44 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 182 2e-44 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 182 2e-44 UniRef50_D0FNJ3 Conserved uncharacterized protein n=2 Tax=Erwini... 181 2e-44 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 179 2e-43 UniRef50_B1T1D8 Pyruvate carboxyltransferase n=1 Tax=Burkholderi... 178 2e-43 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 177 4e-43 UniRef50_C5AMG4 MhpE-like protein n=1 Tax=Burkholderia glumae BG... 176 9e-43 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 176 1e-42 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 175 3e-42 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 174 4e-42 UniRef50_C1YV80 Isopropylmalate/homocitrate/citramalate synthase... 172 1e-41 UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga ma... 171 4e-41 UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma pr... 170 4e-41 UniRef50_D1PP40 Putative uncharacterized protein n=1 Tax=Subdoli... 170 5e-41 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 169 1e-40 UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria Re... 168 3e-40 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 167 4e-40 UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier ... 167 4e-40 UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular ... 167 5e-40 UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 167 6e-40 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 166 1e-39 UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferrop... 165 3e-39 UniRef50_D0LRX4 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 163 7e-39 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 161 3e-38 UniRef50_Q1IEM5 Putative uncharacterized protein n=1 Tax=Pseudom... 160 5e-38 UniRef50_C5CLY8 Pyruvate carboxyltransferase n=1 Tax=Variovorax ... 160 5e-38 UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 160 7e-38 UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax... 159 1e-37 UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=St... 159 1e-37 UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 159 2e-37 UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus... 158 3e-37 UniRef50_A1WEM7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Verminep... 155 1e-36 UniRef50_B0T0Z5 Pyruvate carboxyltransferase n=3 Tax=Bacteria Re... 154 5e-36 UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Ta... 153 1e-35 UniRef50_C0WJX1 Possible pyruvate carboxylase n=1 Tax=Corynebact... 152 1e-35 UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular... 152 2e-35 UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermu... 151 4e-35 UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular... 150 5e-35 UniRef50_A6LCK8 Carboxylase, putative n=7 Tax=Bacteroidales RepI... 148 2e-34 Sequences not found previously or not previously below threshold: UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales... 222 1e-56 UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase... 215 2e-54 UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora ... 213 8e-54 UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 207 5e-52 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 205 2e-51 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 201 4e-50 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 199 1e-49 UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methano... 197 5e-49 UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methyla... 197 7e-49 UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase... 195 2e-48 UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrige... 193 7e-48 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 189 1e-46 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 187 5e-46 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 182 1e-44 UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota... 182 1e-44 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 179 1e-43 UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga le... 179 2e-43 UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO 178 2e-43 UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 178 3e-43 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 177 4e-43 UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria Rep... 177 6e-43 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 177 6e-43 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 174 3e-42 UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferrop... 174 5e-42 UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillu... 174 6e-42 UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcu... 172 2e-41 UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectria... 170 6e-41 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 169 1e-40 UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clost... 169 1e-40 UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transf... 168 2e-40 UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase... 167 4e-40 UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus... 167 5e-40 UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus... 167 6e-40 UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 166 1e-39 UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 165 3e-39 UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella ... 162 1e-38 UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae R... 162 2e-38 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 162 2e-38 UniRef50_C5VE99 Pyruvate carboxylase subunit B n=3 Tax=Corynebac... 161 3e-38 UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geother... 161 3e-38 UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transf... 160 4e-38 UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase ... 158 2e-37 UniRef50_B0TEI2 Oxaloacetate decarboxylase, alpha subunit n=27 T... 158 3e-37 UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copr... 158 3e-37 UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospi... 158 3e-37 UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma l... 157 4e-37 UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepI... 157 5e-37 UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular orga... 156 9e-37 UniRef50_C5A1I6 Pyruvate carboxylase subunit B (PycB) n=18 Tax=A... 154 4e-36 UniRef50_D1B6M4 Pyruvate carboxylase n=2 Tax=Synergistaceae RepI... 154 5e-36 UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 153 7e-36 UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicr... 152 1e-35 UniRef50_Q7NM88 Oxaloacetate decarboxylase alpha chain n=1 Tax=G... 152 2e-35 UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase ... 152 2e-35 UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasil... 152 2e-35 UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 151 4e-35 UniRef50_B1G528 Pyruvate carboxyltransferase n=2 Tax=Proteobacte... 150 6e-35 UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria Re... 150 9e-35 UniRef50_B2A6U5 Conserved carboxylase region n=10 Tax=Bacteria R... 149 1e-34 UniRef50_Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit... 149 2e-34 UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkhold... 148 3e-34 >UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteria RepID=HOA_GEOTN Length = 342 Score = 363 bits (931), Expect = 6e-99, Method: Composition-based stats. Identities = 184/338 (54%), Positives = 246/338 (72%), Gaps = 3/338 (0%) Query: 1 MNGKK-LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ ++ ++I++V LRDG HAI HQY++E V +A+ALD+A V IEV+HGDGL GSS Y Sbjct: 1 MSSERDIWITEVALRDGSHAINHQYTVEQVVSVAQALDEANVPYIEVSHGDGLAGSSLQY 60 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 G ++E IEAA V K AKIA LLLPGIGTI +L A + G ++VR+ATH TEAD+S Sbjct: 61 GLSRTDEMELIEAAVSVCKKAKIAVLLLPGIGTIRELDAAAKRGVKMVRIATHVTEADIS 120 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 AQHI A+ELG++ VGFLMMSHM + E L +QAKLME YGA +YVVDS GA+ ++ + Sbjct: 121 AQHITRAKELGLEAVGFLMMSHMASTEKLVEQAKLMESYGADVVYVVDSAGALLPHEVTE 180 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R RALK L + G H H+NLSL +AN++AA++EG RID S+ +GAGAGN EV Sbjct: 181 RIRALKQSLG--IEIGFHGHNNLSLAMANTLAAIQEGATRIDGSVRCLGAGAGNTQTEVL 238 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 +A D++G + G DLY +MD A+++V P+ P + R++L LGYAGVYSSF H E AA Sbjct: 239 VAVLDRIGLKTGVDLYKMMDLAEEIVAPILQVPQEITRDSLILGYAGVYSSFRLHAERAA 298 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 R+G+ + DILVELGKR++VGGQEDMI+D+A ++ + K Sbjct: 299 KRFGVDSRDILVELGKRKVVGGQEDMIIDIAAEIASKK 336 >UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bacteria RepID=HOA1_FRASN Length = 377 Score = 360 bits (925), Expect = 3e-98, Method: Composition-based stats. Identities = 228/328 (69%), Positives = 258/328 (78%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 LY+ DVTLRDGMHA+RH+YS+E R IA ALD + V +IEVAHGDGL GSS NYG GAH+ Sbjct: 27 LYVQDVTLRDGMHAVRHRYSVETARTIATALDASGVRAIEVAHGDGLAGSSINYGIGAHT 86 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D EWIEA V +A +LLLPGIGT+ DL+ A G R VRVATHCTEAD+SAQHI Sbjct: 87 DWEWIEAVTASVTNAIPTSLLLPGIGTVRDLRQAHALGIRSVRVATHCTEADISAQHISA 146 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 AR+LGMD GFLMMSHM P LA+QA+LME YGA C+YV DSGG + M D+RDRFRA Sbjct: 147 ARDLGMDVAGFLMMSHMAAPAELARQARLMESYGAHCVYVTDSGGRLTMDDVRDRFRAYS 206 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L P T+TG+HAHHNL LGVAN++ AVE G R+DASLAG GAGAGN PLE FIA AD Sbjct: 207 DVLDPATETGIHAHHNLGLGVANTVVAVENGATRVDASLAGQGAGAGNCPLEAFIAVADL 266 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 +GW+HG +L+ LMD ADD+VRPLQDRPVRVDRETL LGYAGVYSSFLRH E AA RYGL Sbjct: 267 MGWKHGCELFGLMDTADDVVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAAATRYGLD 326 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDL 333 IL E+G+R MVGGQEDMIVDVALDL Sbjct: 327 TRTILAEVGRRGMVGGQEDMIVDVALDL 354 >UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Proteobacteria RepID=HOA3_AZOSB Length = 346 Score = 352 bits (902), Expect = 1e-95, Method: Composition-based stats. Identities = 193/337 (57%), Positives = 247/337 (73%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + G ++ + D+TLRDGMH RH +LE ++ IA+ LD A + IEV HGDGL GSS NYG Sbjct: 3 LRGTRITVHDMTLRDGMHPKRHLMTLEQMKTIAQGLDQAGIPLIEVTHGDGLGGSSVNYG 62 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F AH+D E++ A ++K AK++ LLLPGIGT+ LK A + G +RVATHCTEADVS Sbjct: 63 FPAHTDEEYLGAVIPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRVATHCTEADVSE 122 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 QHI+YAR+LGMDTVGFLMM+HM +PE L +QAKLME YGA CIYV DS G + ++ R Sbjct: 123 QHIRYARKLGMDTVGFLMMAHMNSPEGLVQQAKLMESYGANCIYVTDSAGHLLPDTVKAR 182 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 A++A LKPET+ G H HHNL++GVANSIAA+E G RIDA+ AG+GAGAGN P+EV I Sbjct: 183 IGAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVLI 242 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 A D +G + G D++ + D A+DLV P+ D P+R+DR+ L LGYAGVY SFL + A Sbjct: 243 AVCDLMGIETGVDVFKIQDVAEDLVVPIMDFPIRIDRDALTLGYAGVYGSFLLFAKRAEK 302 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 +YG+ A +ILVE+G+R MVGGQEDMI D A+ L K Sbjct: 303 KYGVPAREILVEMGRRGMVGGQEDMIEDTAITLAKAK 339 >UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacteria RepID=HOA2_RHOOB Length = 347 Score = 349 bits (896), Expect = 8e-95, Method: Composition-based stats. Identities = 167/337 (49%), Positives = 222/337 (65%), Gaps = 5/337 (1%) Query: 1 MNG---KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSF 57 MN KK+ I D TLRDGM ++ HQ++ +NV IA+ LD A V +IEVAHG GL SS Sbjct: 1 MNTPAQKKITIVDTTLRDGMSSVSHQFTPQNVADIARGLDRAGVGTIEVAHGIGLGASSI 60 Query: 58 NYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD 117 YGF A +D +++ AA D V++A IA L +PGI T+ +L+ A AG + VRVA HCTEAD Sbjct: 61 QYGFAAATDPDYVRAAVDAVENADIAALYVPGIATLAELQKAIDAGIKTVRVAVHCTEAD 120 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 Q +++A+E G+ + FLMMSH PE LA+QA ++ YGA +YVVDS GAM Sbjct: 121 CGQQPVEWAKEQGLTVMTFLMMSHKLDPEPLAEQAAKLDSYGADVVYVVDSAGAMVPRHA 180 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 DR AL+ + + G HAH+NL +G+AN++ A E G ID SL G+GA AGNA E Sbjct: 181 GDRVAALRQAISAD--IGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTE 238 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 V AA ++ GW G DL+ L+D A+ +V PL P VD L LGYAGVYS+F + Sbjct: 239 VLAAAFERAGWDTGVDLFPLIDTAEHIVAPLMKEPQIVDETALILGYAGVYSTFFHPTKR 298 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 AA ++G+ A DIL+ELG+R ++GGQEDMI+DVA +L Sbjct: 299 AAKKFGVPARDILMELGRRGVIGGQEDMIIDVASELA 335 >UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocardia farcinica RepID=HOA2_NOCFA Length = 346 Score = 346 bits (888), Expect = 7e-94, Method: Composition-based stats. Identities = 163/332 (49%), Positives = 218/332 (65%), Gaps = 2/332 (0%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + + D TLRDGM ++ H+++ +V IA LD A V +IEVAHG GL SS YGF Sbjct: 5 TRTVTLVDTTLRDGMSSVSHRFTPNDVAAIAAGLDRAGVRTIEVAHGIGLGASSIQYGFA 64 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 A +D E++ AA D V HA IA L +PGI T+ +L+ A +AG R VRVA HCTEAD + Q Sbjct: 65 AATDPEYVRAAVDAVDHADIAVLYVPGIATLAELRAAVEAGIRTVRVAVHCTEADCAQQP 124 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 +++A++ G+ + FLMMSH PE LA+QA +E YGA +YVVDS GAM DR Sbjct: 125 VEWAKDHGLTVMTFLMMSHKLDPEPLAEQAVKLESYGADVVYVVDSAGAMVPRHAGDRVA 184 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 AL+ + + G HAH+NL +G+AN++ A E G ID SL G+GA AGNA EV AA Sbjct: 185 ALRRAIS--AEIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTEVLAAA 242 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 ++ GW G +L+ L+D A+ +V PL P VD L LGYAGVYS+F + AAA++ Sbjct: 243 FERAGWHTGVELFPLIDTAEQVVAPLMTEPQIVDETALVLGYAGVYSTFFHPTKRAAAKF 302 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 G+ DIL+ELG+R ++GGQEDMIVDVA +L Sbjct: 303 GVPTRDILLELGRRGVIGGQEDMIVDVASELA 334 >UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD Length = 333 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 145/334 (43%), Positives = 206/334 (61%), Gaps = 2/334 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D+TLRDG HA HQ++ E + +A+ +D V +IE HG+GL GS+ YGF A Sbjct: 2 KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFGHGNGLGGSALQYGFAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D E++EA A VVK+A ++ ++LPG+GT H+L A + GA+ R+ T TE D++ QHI Sbjct: 62 ATDREYMEAVAPVVKNADLSIIILPGVGTRHELHLAKEFGAKYARMCTQITEVDIAEQHI 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A++LGM + L + + ++ + ++ E YGA IY++D GG +R A Sbjct: 122 KMAKQLGMIPIAVLPCAGIIPVKDTVRYTQMAESYGAEVIYLLDGGGYQLPEQTYERIAA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 +K + + G H H+NL L VANS AAVE G + ID L G GAGAGN P E+F A Sbjct: 182 MKKAV--DVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFGAGAGNCPTEIFAAVM 239 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 D++ G DLY MD A+ +RPL R + VD + + LGYAG YSSFL + A ARYG Sbjct: 240 DRMEIDCGIDLYKTMDIAEQYLRPLMPRAMEVDNDRIMLGYAGCYSSFLLFAQRAGARYG 299 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + DI+ E+G+R+ GQED+ +DVA L K Sbjct: 300 VDPRDIIKEIGRRQCTEGQEDICIDVAYALAQKK 333 >UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bacteria RepID=HOA1_MYCSJ Length = 363 Score = 338 bits (868), Expect = 1e-91, Method: Composition-based stats. Identities = 168/331 (50%), Positives = 220/331 (66%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ++D +LRDG H RHQ++ + V I ALD A V IEV HGDGL GSSFNYGF Sbjct: 13 VRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTP 72 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 + E I+ AA+ K AKIA L+LPG+GT D+K A G + R+ATHCTEADVS QH Sbjct: 73 EQELIKLAAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGL 132 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 ARELG++TVGFLMMSH PE LA+QA++M G C+YVVDS GA+ + +RDR AL Sbjct: 133 ARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALV 192 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 AEL + Q G H H NL LGVANS+ AV G +ID S GAGAGNAP+E I DK Sbjct: 193 AELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDK 252 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 +G + G D + + DAA+++V P +DR L +GY+GVYSSFL+H + RYG+ Sbjct: 253 IGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVP 312 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A +L G+R+++GGQED ++D+AL+++ Sbjct: 313 AHQLLHRAGQRKLIGGQEDQLIDIALEIKRE 343 >UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseudomonas pseudoalcaligenes RepID=HOA1_PSEPS Length = 347 Score = 333 bits (853), Expect = 7e-90, Method: Composition-based stats. Identities = 167/338 (49%), Positives = 219/338 (64%), Gaps = 1/338 (0%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + GK + + D++L MH + +LE + + LD R+ IE+ DGL G S NY Sbjct: 3 LQGKNVTLYDMSLLXFMHPNPYHITLEQMIAVPTVLDAPRIPLIEITLRDGLGGRSINYV 62 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F AH D E++ A +K AK++ LLLPGIGT+ L A G + VATHCTEADVS Sbjct: 63 FPAHIDEEYLRAVIPRLKQAKVSALLLPGIGTVDHLNMALDCGVSTILVATHCTEADVSE 122 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKL-MEGYGATCIYVVDSGGAMNMSDIRD 179 HI +R LG DTVGFLMM+HM A A+L ++ YGA CIY DS G M ++ + Sbjct: 123 HHIGMSRMLGADTVGFLMMAHMIRRGKSAGAARLDVKCYGANCIYCTDSAGYMLPDEVSE 182 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 + L+AEL P T+ G H HHN+ + +ANS+A G RID S+AG+GAGAGN PLEVF Sbjct: 183 KIGLLRAELNPATEIGFHGHHNMGMAIANSLAGHRGGASRIDGSVAGLGAGAGNTPLEVF 242 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 +A ++G + G DLY +MD A+DLV P+ D+P+RVDR+ L LGYAGVYSSFL + A Sbjct: 243 VAVCKRMGVETGIDLYKIMDVAEDLVVPMMDQPIRVDRDALTLGYAGVYSSFLLFAQRAE 302 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 +YG+ A DILVELG+R VGGQEDMI D+ALD+ + Sbjct: 303 KKYGVPARDILVELGRRGTVGGQEDMIEDLALDMSRAR 340 >UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta proteobacterium KB13 RepID=B6BTH8_9PROT Length = 337 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 132/337 (39%), Positives = 193/337 (57%), Gaps = 3/337 (0%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ ISD TLRDG HAI+H++S +++ K D AR+ +EV HG+G+ SS G Sbjct: 1 MESKKILISDPTLRDGSHAIKHKFSKDDISNYCKLADKARIPIVEVGHGNGIGASSLQLG 60 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEADVS 119 SD + + A +K +K+ ++PG TI D+ A G V R+ATHCTE+D+S Sbjct: 61 ESLLSDFDMLSTARKNLKKSKLGVHVIPGFATIDKDILPAVDVGVDVFRIATHCTESDLS 120 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 +HI + R+ ++ G LMM+HM E L QAK +E YGA + +DS G+ + I++ Sbjct: 121 ERHISFLRKKNLEVWGCLMMAHMVDTETLIDQAKKIENYGADGVIFMDSAGSFIPNQIKE 180 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R L +EL G H H+NL+L VANS+ A++ G +DA AG GAGAGN LEV Sbjct: 181 RVEGLVSEL--NIMVGFHGHNNLNLAVANSLEAIQSGATLVDACSAGFGAGAGNTQLEVL 238 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 I K + D L+D A+ ++ V +++ GY GV+S FL A Sbjct: 239 IPVLLKQNFDTNIDFNGLLDLAEFVISKFGKSTSSVHIDSMISGYYGVFSGFLVPVRRVA 298 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 Y +S +DI ELG+R ++ GQED+I++VA +R+ Sbjct: 299 LEYKISPIDIFKELGRRNIIAGQEDLIIEVANSIRDK 335 >UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS Length = 352 Score = 306 bits (783), Expect = 9e-82, Method: Composition-based stats. Identities = 97/335 (28%), Positives = 172/335 (51%), Gaps = 3/335 (0%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ I D TLRDG +++ ++ + I L+ + + IEV HG G S+ YG Sbjct: 2 SKKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVGHGLGFNASNSGYGKS 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 SD E++ AA + + + +PGI + DL+ A + G +RV T T+ S + Sbjct: 62 TQSDEEYMIAAKESLSKSMYGMFCIPGIAKLSDLELAKKHGMGFIRVGTDVTKVHQSEKF 121 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I+ A+ LG M S++ P+ A K E +G +Y+VDS G M SD+ + + Sbjct: 122 IKKAKNLGFFVASNFMKSYVMPPDKFASIVKQSEEFGTDMVYIVDSAGGMFSSDLLEYYN 181 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +++ E G H H NL + ++NS+ A + G + ID+SL G+G +GNA EV + A Sbjct: 182 SIRN--VSEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGIGRSSGNACTEVLVMA 239 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 K G++ D ++L +A + V PL + ++ + + GYA +SS++ H ++++ Sbjct: 240 LKKKGFKIDVDFHSLFEAGQECVYPLINNSNKLPLD-IVSGYADFHSSYMHHIMKYSSKF 298 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + + +++E K + E + +A L+ + Sbjct: 299 KVDPLLLIIEYSKINKIDIDEKKLEQIAKKLKRKQ 333 >UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus jostii RHA1 RepID=Q8KZT0_RHOSR Length = 359 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 161/336 (47%), Positives = 201/336 (59%), Gaps = 10/336 (2%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG HA HQ++ VR +ALD A V+ IEV HGDGL GS+FNYGF S Sbjct: 10 VRIVDTTLRDGSHAQSHQFTESQVRDTVRALDGAGVEVIEVTHGDGLGGSTFNYGFSRIS 69 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 DLE ++ AAD + AKIA LL+PGIGT DL+ A GA VVR+ATHCTEADVS QH + Sbjct: 70 DLELVQVAADTAEQAKIAVLLVPGIGTADDLRKAADRGAEVVRIATHCTEADVSLQHFEI 129 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 AR+LGM T GFLMM+H TTPE LA+QA+LM G YV DS GA+ M + +DRF AL Sbjct: 130 ARDLGMQTCGFLMMAHRTTPEELARQARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALI 189 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 E+ + G H H N+SLGVANS+ A E G ID SL +GAG+GN+P E+ A D+ Sbjct: 190 TEVGDDAWVGYHGHQNMSLGVANSVIAYEAGVRYIDGSLCALGAGSGNSPTELLAAIFDR 249 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPV-RVDRETLALGYAGV----YSSFLRHC-ETAA 299 + + A D R P V R+++ + V YSSFL H + Sbjct: 250 MNIRD----RARRDGDIGCSRDSWCGPTSTVGRKSIGMRSCRVGSAWYSSFLLHAGDRGR 305 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + A + V VGGQEDMI+DVA+ L Sbjct: 306 PVWRSGARESCVAAANWGYVGGQEDMIIDVAIQLAK 341 >UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseobacter sp. SK209-2-6 RepID=A4F0P9_9RHOB Length = 352 Score = 299 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 165/330 (50%), Gaps = 2/330 (0%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + I Q++ + I ALD A IEV HG G+ S A SD Sbjct: 8 KVLDCTLRDGSYVIDFQFTSADTESIGGALDQAGFPYIEVGHGVGMGASETGNNVAAASD 67 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYA 126 +++ AAA V K +PG+ + ++ A G +RV T +AD + I+ A Sbjct: 68 ADYMAAAAKSVTSGKWGMFCIPGVANLDHVRLAADHGIGFIRVGTDVAQADSAIPFIELA 127 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 R+LG++ M S++ PE A YGA +Y+VDS G M ++R +A K+ Sbjct: 128 RKLGIEVFANFMKSYVLEPEAFGALAARSYDYGAEMVYLVDSAGGMLPHEVRAYLQAAKS 187 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 PE G H H NL L VANS+ ++EEG +D SL G G +GN E+F+ A + Sbjct: 188 A-APELPLGFHGHDNLGLAVANSLVSLEEGAAMVDTSLQGFGRSSGNTATELFLGATIRS 246 Query: 247 GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSA 306 G++ + +MD + LVRPL +R + +A G A +SS++ A + + Sbjct: 247 GYEAFAEPIEVMDLGETLVRPLIERRGFCSLD-IAAGQALFHSSYMPKILRVAKQNRVDP 305 Query: 307 VDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +++EL K V ++++ +A +L N Sbjct: 306 RRLIIELCKHDKVNAPDELLSRLAAELSEN 335 >UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkholderia RepID=HOA_BURP0 Length = 347 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 131/332 (39%), Positives = 187/332 (56%), Gaps = 2/332 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ISD TLRDG HAIRHQ S + A+A D+A +D +EV HG+GL GSS G Sbjct: 2 ILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGNGLGGSSCLLGQTPIG 61 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D +E A ++ +++ +PG+G D+ A + G VVRVATHCTEA+VSA+ I+ Sbjct: 62 DRLMLETARAALRTSRLGVHFIPGLGKAADISLALEIGVDVVRVATHCTEANVSARFIEQ 121 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 R G G LMMSHM P+ L QAKLME YGA + ++DS G S +R + L Sbjct: 122 TRTAGRTAFGVLMMSHMAPPDTLLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLV 181 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L + G HAH+NL L VANS+ A+E G +DA + G GAGAGN LE +AA ++ Sbjct: 182 DGL--DIDVGFHAHNNLGLAVANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMER 239 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 G T +M A L + + +A G G++S ++ H + AA +G++ Sbjct: 240 EGHDTRTTFERVMTLARGTETFLNPKTPHIQPANIASGLYGLFSGYVPHIQKAAQEFGVN 299 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L +R++V GQED+I++ A L + Sbjct: 300 EFELYKRLAERKLVAGQEDIIIEEASRLARER 331 >UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR Length = 354 Score = 294 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 101/336 (30%), Positives = 169/336 (50%), Gaps = 4/336 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I + TLRDG + I Q+S +N IA ALD+A + IEV HG GL + G Sbjct: 1 MNNPK--ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHGVGLGATEKKIG 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 SD ++++AA+ V + K +PGI T+ L+ A +R+ + + S Sbjct: 59 VALESDEVYMKSAAESVTNGKWGMFAIPGIATLEHLEMAKNYDMDFIRIGSTIEDFPKSE 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + A+ GM T M S+ PE+LA+ +KL G +YVVDS G M ++++ Sbjct: 119 AFVSSAKSQGMMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSAGGMLPNEVKLY 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 A+ AE K + G H H+NL LG+ N++AA+E G ID SL G G AGN E + Sbjct: 179 VEAILAE-KSDAVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGFGRSAGNTTTEQML 237 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 ++G + D +MD ++L++P+ ++ +T++ G A +SS++ + Sbjct: 238 GCLARMGLEGNIDPIKVMDIGEELIKPMIEKRGLTSIDTVS-GMALFHSSYMPVIHEMST 296 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +Y + ++ + +V + +++ A + Sbjct: 297 KYRVDPRQLISAVCSEDIVNAESELVEHHAKAIAEA 332 >UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG Length = 340 Score = 293 bits (750), Expect = 6e-78, Method: Composition-based stats. Identities = 131/331 (39%), Positives = 183/331 (55%), Gaps = 1/331 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG HA+ H+ L +R+ A+A D ARV +EV HG+GL SS G A Sbjct: 2 KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVGHGNGLGASSLQVGLAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D + + ++H+++ T +LPG GT DL+ A G V RV H TEA ++ H+ Sbjct: 62 ATDDAMLSTVREALRHSRLGTFMLPGWGTSDDLRRAISHGVDVFRVGVHATEASLAEHHL 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + R+ G + LMMSHM +P LA+QA GYGA + ++DS G D+ R A Sbjct: 122 GFLRDAGAEAHCVLMMSHMASPGELAEQAARAVGYGAQAVGIMDSAGHFLPPDVTARIGA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 + + H H+NL + VANS+AA E G ID G GAGAGN LEV + Sbjct: 182 IVEAVGT-VPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGAGNTQLEVLVPVL 240 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 ++ G+ G DLYAL+DAAD R L P ++ G AGV+S F A G Sbjct: 241 ERSGFATGIDLYALLDAADLAERELMPAPPVPASMSIVSGLAGVFSGFKHRVVELAGAAG 300 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 + ++ ELG+R+ + GQED+IVDV +L Sbjct: 301 VDPREVFFELGRRQAIAGQEDLIVDVVAELS 331 >UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB Length = 830 Score = 286 bits (733), Expect = 6e-76, Method: Composition-based stats. Identities = 89/335 (26%), Positives = 154/335 (45%), Gaps = 8/335 (2%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 I D TLRDG + ++L+ R + L ++ IEV HG GL + +D Sbjct: 2 KILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGHGIGLGATEKGISPAVETD 61 Query: 67 LEWIEAAADVV-----KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 ++++AAA V + AK +PGI ++ + A +R+ + +++ Sbjct: 62 QDYMKAAALAVEESGSQKAKWGMFCIPGIAELNHIDLAHDHNMGFIRIGVTVEDINLARS 121 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++ +++LG+ M S+ ++P+ + +GA Y+VDS G M +D+ D F Sbjct: 122 FVEKSKKLGLYVCVNFMKSYTSSPQEFSAAVAQAASFGADIAYLVDSAGTMVPADVEDYF 181 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 R ++ G H H+NL L N+ A EG +D S+ GMG GN E F+A Sbjct: 182 RTVRRN--SILPLGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTEHFLA 239 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAAR 301 K G H D LMD ++ VRP + +D +A G AG +SS++ + + Sbjct: 240 LLGKQGIAHNLDPIGLMDLSEKYVRPKLTD-IGIDSVDVACGLAGFHSSYMSVIKKYSLE 298 Query: 302 YGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 Y + +++EL K E ++ + A ++ Sbjct: 299 YDIDPRRLIIELCKETRDAAPEKLVKEKAEIIKKQ 333 >UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salinispora arenicola CNS-205 RepID=HOA2_SALAI Length = 348 Score = 283 bits (725), Expect = 5e-75, Method: Composition-based stats. Identities = 133/326 (40%), Positives = 185/326 (56%), Gaps = 3/326 (0%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 KL I D TLRDG HA+ HQ ++ A+A ++A VD +EV HG+GL SS G A Sbjct: 4 KLQICDSTLRDGNHAVAHQLGRADISAYARAAEEAGVDVLEVGHGNGLGASSIQVGIAAV 63 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEADVSAQHI 123 SD E + AA ++++++ L +PG ++ DLK A G VRV HCTEADV+ Q I Sbjct: 64 SDAEMLRAAKAELRNSRLGVLSIPGFASVERDLKPALDCGVDEVRVGAHCTEADVTRQQI 123 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 R +G+ G L+MSHM + L +QA LM+ YGA + ++DS GA +R++ Sbjct: 124 TMLRSMGVRVKGLLLMSHMASAGKLVEQAGLMQEYGAEAVVLMDSAGAYTPEMVREKVGE 183 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L +L + G HAH+NL L V NSI AV G +D + G GAGAGNAP+E+ A Sbjct: 184 LVEKL--DIAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGAGNAPIELVAANL 241 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + L+ +DAAD D T+A G AGV+S F A+ R+G Sbjct: 242 HVEQIEARIKLFDALDAADTAEERFVKHVPTNDGVTIASGIAGVFSGFAAPVRRASRRFG 301 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDV 329 + +IL+ELG+RR+V GQED I++V Sbjct: 302 VDPREILLELGRRRVVAGQEDTIIEV 327 >UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0IC26_VIBHO Length = 355 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 101/334 (30%), Positives = 164/334 (49%), Gaps = 3/334 (0%) Query: 4 KKL-YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + I + TLRDG + I Q+S + I KALD A + IEV HG GL S N G Sbjct: 2 KNIPTILECTLRDGSYEIDFQFSKKQTSDICKALDTAGFELIEVGHGVGLGASEKNIGVA 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +D ++EAAA+ VK+ K +PGI H L A +R+ + + S++ Sbjct: 62 LETDEVYMEAAANNVKNGKWGMFAIPGIAEKHHLDIASDYDMDFIRIGSTIEDFPKSSEF 121 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I A+ L M T M S+ + PE LA + G +YVVDS G M +++++ Sbjct: 122 IDKAKSLSMMTCVNFMKSYTSKPEKLAIASSAAFEMGVDVVYVVDSAGGMLPNEVKNYVE 181 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 A+KAE G H H+NL LG+ N++AA+ G ID SL G G AGN E + Sbjct: 182 AIKAE-NTNAIVGFHGHNNLGLGIGNALAALNAGASIIDTSLQGFGRSAGNTTTEQMLGC 240 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 ++G + D +MD ++L++PL ++ +T++ G + +SS++ + +Y Sbjct: 241 LARMGIEGKIDPIVVMDIGEELIKPLIEKRGLTSLDTVS-GISLFHSSYMPTIHDMSVKY 299 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + ++V + +V +++ A + Sbjct: 300 RVDPRLLIVSVCSEDIVNANAELVEKHAKLIAEE 333 >UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ferrooxidans DSM 13031 RepID=Q0YTT0_9CHLB Length = 681 Score = 276 bits (705), Expect = 9e-73, Method: Composition-based stats. Identities = 99/313 (31%), Positives = 158/313 (50%), Gaps = 3/313 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + I +Q++ + IA L+ + ++ IEV HG GL G A + Sbjct: 8 VDILDTTLRDGSYTIGYQFTADETALIAHGLELSGINYIEVGHGLGLGADRAGKGAQAVT 67 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 DL ++ A ++ ++ A+ +PGIG + DLK G VRV D + I+ Sbjct: 68 DLVYMRACSNAIRRARFGFFYIPGIGELSDLKLLADEGGAFVRVGVSLDAIDQACHAIRE 127 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 A+ LG++ +M + + + + + GA +YVVDS G M S++ + ++ Sbjct: 128 AKRLGLEVWANIMKIYAYSLKESREGSLRFVEAGADGVYVVDSAGGMLPSEVAEYVSEIR 187 Query: 186 AEL---KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 E + G H H NLSL A S++AV GCD +D SL G+G GNA EV Sbjct: 188 KEFTLAGVSARIGFHGHDNLSLSTACSLSAVGAGCDIVDGSLLGIGRSIGNAATEVLAMV 247 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 + G++ G + + D A+ +RP ++ R ALG+A ++S FL E AA +Y Sbjct: 248 LCRAGYETGVNAWNAGDLAEKTIRPFLEQRWRHSSLEQALGFAQIHSGFLPLLEKAALQY 307 Query: 303 GLSAVDILVELGK 315 +S D+++ LG Sbjct: 308 QISLRDVVLVLGH 320 >UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34E31 Length = 351 Score = 250 bits (639), Expect = 5e-65, Method: Composition-based stats. Identities = 88/337 (26%), Positives = 150/337 (44%), Gaps = 6/337 (1%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N KK+ + D TLRDG + + +S E + L +V IE + G+ Sbjct: 17 NKKKIQLMDCTLRDGANVVGKGFSAEITDMVLDGLTSCKVPIIEFGNAGGIGAYEVAGFT 76 Query: 62 GAHSDLEWIEAAADVV-KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A +D E++E A + + ++I L + A + G +RV + ++ Sbjct: 77 NALTDSEYLEIAKKYLNRGSEIGMFLNAKRYREKYVDMAAENGLAFLRVGADAGDGSIAL 136 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 Q I ++ GM M +++ T + LA++ K +E G I ++DS G M + + Sbjct: 137 QAIADIKKRGMKAYYSAMKAYLLTADELAEEGKRLEEAGLDEITIMDSAGTMLPEQVAEY 196 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 R L + H H+NL L AN+IAA E G D +D L GM AGN P E+ Sbjct: 197 TRKLSEAVS--IPVAFHCHNNLGLSAANAIAAFENGADILDCGLMGMARSAGNLPTEICA 254 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPV---RVDRETLALGYAGVYSSFLRHCET 297 A +LG DLY ++ + + P ++ V + LGY+G +SSF++ + Sbjct: 255 AMMRRLGQMEEIDLYGMLSFIKNRLEPAMEKHSYHNPVKPLDVVLGYSGCHSSFVKTFQA 314 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A G+ ++ E+ + ++++ A LR Sbjct: 315 VAEEKGVDLFRLICEVSEIDKKSPSKELMEQTADKLR 351 >UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=Mycobacterium tuberculosis complex RepID=A5U8E4_MYCTA Length = 336 Score = 248 bits (633), Expect = 2e-64, Method: Composition-based stats. Identities = 91/312 (29%), Positives = 157/312 (50%), Gaps = 4/312 (1%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + ++ A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQG-PAA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 H+D E+ AA VV++A++ +++P + I + A +R+ TE ++ + Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDY-LDFLRICVIATEFELVMPFV 125 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R A Sbjct: 126 ERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA 185 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +AA Sbjct: 186 LRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAAL 243 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + G DL + DAA + + +D ++ G+ G+ S + H AA + G Sbjct: 244 QRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAG 303 Query: 304 LSAVDILVELGK 315 LS ++ + K Sbjct: 304 LSVSHVIRQTAK 315 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 246 bits (627), Expect = 1e-63, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 129/338 (38%), Gaps = 41/338 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++Y+ D TLRDG Q S +IAKAL+ VD IE G Sbjct: 5 PNRVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPG-------- 56 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D + + + V+ I L G I A Q A+ R+ T +D+ ++ Sbjct: 57 ---DFQSVVEMSKAVQEPIICALTRANKGDIDSAVAALQY-AKRPRIHTGIGSSDMHIKY 112 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 ++YA++ D + + LA+ + + GAT + + Sbjct: 113 KFNSTREKILERAVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIP 172 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + LK +K + +H H++L L AN++A + G +I+ ++ Sbjct: 173 DTNGYCLPDQYGSKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTI 232 Query: 225 AGMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGN LE + LG + D ++ + R P+Q + + Sbjct: 233 NGIGERAGNTALEEVVMILKTHHALGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQ 292 Query: 278 ETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV 311 A FL+H E G+++ DI++ Sbjct: 293 NAFAHSSGIHQDGFLKHRENYEIMNPEDVGINSADIIL 330 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 119/312 (38%), Gaps = 34/312 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDG + QIAK LD VD IE +G Sbjct: 2 RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 + E ++ A++ +AKI L D+ A +A +V V ++ V Sbjct: 53 --EFEAVKEIANLGLNAKICGL---ARVVKKDIDQAIKADVDIVHVFIPTSKIQVEHTIK 107 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 S ++Y + G++ + M + T + L + K +E G I V D+ Sbjct: 108 KTPDEIVQLSVDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G D + LK L +H H++ L AN+ AAV G D + ++ G+G Sbjct: 168 GIATPFRFYDMIKKLKEHL--NVPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGE 225 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGNAPLE +A G++ + L++ + + R + V + Sbjct: 226 RAGNAPLEEVVALLYAEGFKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESG 285 Query: 286 GVYSSFLRHCET 297 L+ T Sbjct: 286 IHAHGVLKDART 297 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 76/320 (23%), Positives = 120/320 (37%), Gaps = 38/320 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E IA LDD VD IE + Sbjct: 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGF-----------PIASD 59 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D E + A K+A I L G I A + R R+ T + + V ++ Sbjct: 60 GDFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIRPAKRG-RIHTFLSTSPVHMKYKL 118 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + AR D T + L + + GA+ I + D+ Sbjct: 119 QMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDT 178 Query: 169 GGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + D F+ ++ + + +H H++L + VANS+A V G +I+ ++ G Sbjct: 179 VGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTING 238 Query: 227 MGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE + A DKL + + D L A+ + P+Q V R Sbjct: 239 IGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRN 298 Query: 279 TLALGYAGVYSSFLRHCETA 298 A L++ +T Sbjct: 299 AFAHESGIHQDGMLKNAQTY 318 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 240 bits (612), Expect = 6e-62, Method: Composition-based stats. Identities = 80/363 (22%), Positives = 139/363 (38%), Gaps = 44/363 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E +A+ LDD VD IE + F + Sbjct: 11 RVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGY-----------PFASD 59 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D E + A K++ I L I A + R R+ T + + V ++ Sbjct: 60 GDFEAVHEIAKRSKNSVICGLSRASHKDIDRCAEAIKPAERG-RIHTFLSTSPVHMKYKL 118 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + AR D + T + L + + GAT I + D+ Sbjct: 119 QMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDT 178 Query: 169 GGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + R+ FR ++ + + + +H H++L + VANS+A V G +I+ ++ G Sbjct: 179 VGYAVPEEYREMFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTING 238 Query: 227 MGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE + A DKL + + + L A+ + P+Q V R Sbjct: 239 IGERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRN 298 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A +++ +T G+ ++ +GK G + ++ L Sbjct: 299 AFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLV--MGKHSGRAGLIHKLEELGYKLS 356 Query: 335 NNK 337 N+ Sbjct: 357 RNQ 359 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 116/302 (38%), Gaps = 7/302 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ + D TLRDG + +IA LD VD IE +G + Sbjct: 15 MQSKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVK 74 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 +++ L+ V I +G +H + ++ Sbjct: 75 SISNAGLDTTVCGLARVLKKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSREEVIQLAV 134 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + +QY ++ G+ + M + T PE L + K ++ G I V D+ G M S + + Sbjct: 135 EAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYRQ 194 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 + + AE+ +H H++ L VANS+ AVE G ++ ++ G+G AGNA L + Sbjct: 195 IKGIAAEIT--IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADLSQTV 252 Query: 241 AAADKL-GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGVYSSFLRHC 295 + + G + L++ + + L V + + L Sbjct: 253 MSLTSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHSQGVLEKS 312 Query: 296 ET 297 +T Sbjct: 313 DT 314 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 237 bits (606), Expect = 3e-61, Method: Composition-based stats. Identities = 80/365 (21%), Positives = 136/365 (37%), Gaps = 48/365 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + + +IAK L+ VD +E QG Sbjct: 3 KINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQG---------- 52 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVSA-- 120 D E + A A+ +K+A + L D+ AW A V R+ + + Sbjct: 53 -DFEGVRAIANTIKNASVTGL---ARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTY 108 Query: 121 --------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + YA + + + L K + + GAT I + Sbjct: 109 KLKKTPEQVIQTAVDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLP 168 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + D F+ ++ ++ + H H +L + VAN+IAAVE G +++ ++ Sbjct: 169 DTVGYTTPQEYGDLFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTI 228 Query: 225 AGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVD 276 G+G AGNA LE A DK + L + +D + + + V Sbjct: 229 NGIGERAGNASLEEIAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVG 288 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 R A L++ T G+ + +++ LGK +D I + + Sbjct: 289 RNAFAHESGIHQDGVLKNASTYEIITPELVGIQSNNLV--LGKHSGRHAFKDKIEQLGYE 346 Query: 333 LRNNK 337 L +K Sbjct: 347 LAEDK 351 >UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J6G8_9BACL Length = 322 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 130/273 (47%), Gaps = 7/273 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSSFN 58 M K I D T+RDG +S+E V+++ L++A VD +E+ + + + + Sbjct: 1 MKANKCKIVDCTIRDGGLVNNWDFSVEFVQKLYAGLNEAGVDYMEIGYKNSPKLLKGADE 60 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 G D +++ K++ L+ G +D+ ++ ++RVA + + D Sbjct: 61 AGPWRFLDDDFLRKVIPQKGTTKLSALVDIGRVDENDILPRSESLLDLIRVACYIKDVDK 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + Q +Q + G +T +M L + ++++ +Y+VDS G+++ D+ Sbjct: 121 ALQLVQLFHDRGYETTLNIMALSNVMEHELLEAFEMIKDSVVDVVYIVDSYGSLDYKDME 180 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 K L P + G+H H+N+ L +N++ A E G + +DAS+ GMG AGN P E+ Sbjct: 181 HLVNKFKTHL-PGKRLGVHTHNNMQLAFSNTLVAAENGVELLDASVYGMGRAAGNCPTEL 239 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 + L +++ ++L+ PL+++ Sbjct: 240 LVTHLKG----TNYKLRPVLEVLEELLIPLREK 268 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 79/366 (21%), Positives = 140/366 (38%), Gaps = 44/366 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 ++ I D TLRDG + + E ++A+ L+ D IE Sbjct: 3 QANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFA-----------A 51 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 + D E + A A + + + +L I A A A R+ T + + + Sbjct: 52 ASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGKAV-APAPKKRIHTFIATSPIHME 110 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + ++ ARE D + + + LA+ + GAT I + Sbjct: 111 YKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINI 170 Query: 166 VDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + FR L A+ + H H++L L VANS+AA++ G +++ + Sbjct: 171 PDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECT 230 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 + G+G AGNA +E + A D G + G D ++ ++ + P+Q V Sbjct: 231 VNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIV 290 Query: 276 DRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 + L+H ET A G SA + LGK + + D+ + Sbjct: 291 GANAFSHESGIHQDGVLKHRETYEIMSAESVGWSANRL--SLGKLSGRNAFKTKLADLGI 348 Query: 332 DLRNNK 337 +L + + Sbjct: 349 ELESEE 354 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 236 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 71/366 (19%), Positives = 135/366 (36%), Gaps = 48/366 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + + QIA+ L VD IE + Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGF-----------PITS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSAQ 121 D E + A VK +A L + D++ AW A A R+ T +D+ + Sbjct: 51 PGDKEAVSLIAREVKGVVVAAL---ARASALDIETAWDAIKDAESPRIHTFIATSDIHLK 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + ++ A++ D + + + L + + GAT I + Sbjct: 108 YKLKMDRETVVERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINI 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + ++ +H H +L L VANS+AA++ G +++ + Sbjct: 168 PDTVGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECT 227 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 + G+G AGN LE + A D L + G + + + P+Q V Sbjct: 228 INGIGERAGNCSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIV 287 Query: 276 DRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 + + L+ T G+ ++ LGK ++ ++++ Sbjct: 288 GKNAFSHESGIHQDGVLKERTTYEIMNPRLVGIPESRLV--LGKHSGRHALKERLLELGY 345 Query: 332 DLRNNK 337 +L + Sbjct: 346 ELTEEQ 351 >UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWI0_PAESJ Length = 320 Score = 236 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 131/275 (47%), Gaps = 9/275 (3%) Query: 1 MNGKK--LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSS 56 MN K I D T+RDG +S+E V+ + L++A VD +E+ + + + + Sbjct: 1 MNSKTSHCKIVDCTIRDGGLVNNWDFSVEFVQHLYNTLNEAGVDYMEIGYKNSPKLLKGA 60 Query: 57 FNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA 116 G D +++ + K++ L+ G +D+ ++ ++RVA + + Sbjct: 61 DTAGPWRFLDDNFLKQVIPNKGNTKLSALVDIGRVDENDILPRSESLLDLIRVACYIQDV 120 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 D + Q +Q E G +T +M L + +L++ +Y+VDS G++ +D Sbjct: 121 DKALQLVQLFHERGYETTLNIMALSNVMENQLIEAFELIKESVVDVVYIVDSYGSLKPND 180 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 + L P + G+H H+N+ L AN++ A E+G + +DAS+ GMG AGN Sbjct: 181 YSYLIEKFQHHL-PNKRLGIHTHNNMQLAFANTLLAAEKGVELLDASVYGMGRAAGNCNT 239 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 E+ +A + ++ ++D + + PL+++ Sbjct: 240 ELLVANLQNAKY----NVRPVLDMIEKYMIPLREK 270 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 234 bits (598), Expect = 3e-60, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 123/334 (36%), Gaps = 45/334 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG +++ IAK L VD IE + Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGF-----------PLTS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATH--CTEADVSAQ 121 D E ++ A V+ I I D+ W+A + H + +D+ + Sbjct: 51 PGDFEAVQRIAREVEGPYICGF---SRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIK 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 H + +A++ + M + T E L + + GAT I + Sbjct: 108 HQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINI 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + ++ ++ + +H H++L + VANSI A G +I+ + Sbjct: 168 PDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECT 227 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRV 275 + G+G AGNA LE + D LG++ G DL L + + R P+ V Sbjct: 228 INGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIV 287 Query: 276 DRETLALGYAGVYSSFLRHCETAAARYGLSAVDI 309 + L+ T + + Sbjct: 288 GKNVFTHESGIHQDGVLKERSTYEV---IDPRLV 318 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 80/367 (21%), Positives = 132/367 (35%), Gaps = 48/367 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG + +L ++A AL D VD IE Sbjct: 15 TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGF-----------PIA 63 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 + D E + A ++ A I L D+ AW+A A R+ + + Sbjct: 64 SPGDFESVRQIATTIRGATICGLARCAE---KDIDRAWEALKTAPQARIHVFLATSAIHR 120 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + ++ A D + T + L + + GAT I Sbjct: 121 EFKLRMTPDEIVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTIN 180 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 V D+ G +I DRF+ L+ + + H H +L + VANS+AAV+ G +I+ Sbjct: 181 VPDTVGYTTPGEIYDRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIEC 240 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLG----WQHGTDLYALMDAADDLVRP----LQDRPVR 274 ++ G+G AGNA LE + A Q + L+ + + + +Q Sbjct: 241 TINGIGERAGNAALEELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAI 300 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V R A L+ T G + D++ LGK D + Sbjct: 301 VGRNAFAHESGIHQDGMLKERTTYEIMSPEEVGFTKTDLV--LGKHSGRAALADRAKQLG 358 Query: 331 LDLRNNK 337 + L + Sbjct: 359 MTLTGEQ 365 >UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XTF5_DESMR Length = 345 Score = 232 bits (593), Expect = 9e-60, Method: Composition-based stats. Identities = 87/339 (25%), Positives = 152/339 (44%), Gaps = 15/339 (4%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQG-SSFNYGFG 62 K + + + TLRDG + + E A+ L IEV HG GL ++ GF Sbjct: 2 KNVTLLECTLRDGAYKVDFMIDQETCCAFAEKLVRIGFQDIEVGHGLGLGAYRQYSAGF- 60 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +D + A + +++ + +P +G D + A G +RV S Sbjct: 61 --TDEALYKRLAPLAARSRLYSFFIPSVGKPDDFRMARDYGLYGLRVGAEPVYVLDSIPT 118 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 ++ A+ LG +M S+ TP+ AK + ++ + IY+VDS G M ++R R Sbjct: 119 LEAAKSLGYFVALNVMKSYTVTPDGFAKLVETVKDF-VDVIYLVDSAGHMLPEELRAYVR 177 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 A++ + G H H+NL L VA+++ ++EG ID +L G+G GN P E +A Sbjct: 178 AIQDRVG-MIALGYHGHNNLGLAVASALELLDEGVQYIDTTLTGIGRSGGNIPTETMLAV 236 Query: 243 A-DKLGWQHGTDLYALMDAADDLVRPLQD------RPVRVDRETLALGYAGVYSSFLRHC 295 K G Q+ +D + L + R ++ + + E + GYAG +SS+ Sbjct: 237 LAKKYGVQYCSDDFLLQTLG--VARQFREYVLSKGKSLDFRSEDILFGYAGFHSSYEDLL 294 Query: 296 ETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A R G ++++ +R V E ++ D+ ++ Sbjct: 295 RREAERQGQDFHQAILDVSRREQVCLTEAILTDIFREIS 333 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 232 bits (593), Expect = 9e-60, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 105/263 (39%), Gaps = 31/263 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N ++ I D TLRDG + +LE IA L VD IE F Sbjct: 4 NPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGF-----------PF 52 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVS 119 + D + + A V T+ + D+K ++A + R+ T +D+ Sbjct: 53 ASPGDFKAVNKIASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIH 112 Query: 120 AQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 +H + YA+ L D + + P+ L + +L GAT I Sbjct: 113 LKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTI 172 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G S+ + + + E +H H++L L VAN + AV+ G +++ Sbjct: 173 NIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLE 232 Query: 222 ASLAGMGAGAGNAPLEVFIAAAD 244 ++ G+G AGNA LE + A Sbjct: 233 CTINGIGERAGNASLEELVMALH 255 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 120/323 (37%), Gaps = 42/323 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ + D TLRDG + + IAK L+ VD IE +G Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVSAQ 121 D ++ A +K+ + L G D+ AW+A V R+ +D+ + Sbjct: 53 --DFLAVQEIARTIKNCSVTGLARSVKG---DIDAAWEALKDGVSPRIHIFIATSDIHLK 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 H ++YA+E + T LA+ + + GA+ I + Sbjct: 108 HKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINL 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + F+ +K + + H H +L + VANS++A+E G D+I+ + Sbjct: 168 PDTVGYLTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECA 227 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTD-------LYALMDAADDLV-RPLQDRPVRV 275 + G+G AGNA LE A H D L D L + V Sbjct: 228 INGIGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIV 287 Query: 276 DRETLALGYAGVYSSFLRHCETA 298 A FL+ T Sbjct: 288 GDNAFAHESGIHQDGFLKEKSTY 310 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 231 bits (588), Expect = 4e-59, Method: Composition-based stats. Identities = 72/325 (22%), Positives = 117/325 (36%), Gaps = 38/325 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +L + D TLRDG + ++AK L VD IE Sbjct: 3 MTANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGF-----------P 51 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 + D E + A VK KI L I A +A A R+ + + Sbjct: 52 VISQGDFESVSEIAAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHR 111 Query: 121 ----------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + ++ A+ D + T PE LAK + + GAT + Sbjct: 112 RFKLAKDEEEIVRIAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVN 171 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + R L ++ + +H H++L L V+NS+AA++ G +++ Sbjct: 172 IPDTVGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEG 231 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLG-----WQHGTDLYALMDAADDLVRP----LQDRPV 273 ++ G+G AGNA LE I A + G L ++ + + R +Q Sbjct: 232 TINGIGERAGNAALEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKA 291 Query: 274 RVDRETLALGYAGVYSSFLRHCETA 298 V A L+ ET Sbjct: 292 VVGENAFAHAAGIHQDGILKKRETY 316 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 76/365 (20%), Positives = 138/365 (37%), Gaps = 48/365 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + +L+ ++A+ L+ VD +E QG Sbjct: 7 RIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQG---------- 56 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSAQH 122 D E ++A A VK ++A L D+ AW+A A R+ T + V Q+ Sbjct: 57 -DFEAVQAIARAVKGVEVAGLC---RAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQY 112 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +++A + + + + P+ L + + + GAT I V Sbjct: 113 KLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVP 172 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQ--TGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + R + + +H H++L +GVAN++AA++ G + + ++ Sbjct: 173 DTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTI 232 Query: 225 AGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVRVD 276 +G+G AGNA LE + A G L L P+ V Sbjct: 233 SGIGERAGNASLEEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVG 292 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 A L++ ET G + D+++ GK ++ + ++ Sbjct: 293 ANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLVI--GKHSGRNAVKNKLDELGYR 350 Query: 333 LRNNK 337 L + Sbjct: 351 LEEAQ 355 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 111/304 (36%), Gaps = 34/304 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I D TLRDG ++ E IA+ L V SIE QG Sbjct: 17 PKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQG-------- 68 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV---- 118 + E ++A A +I L D+ A A + V ++ + Sbjct: 69 ---EFEAVKAIAREGLGPEIVAL---ARANKRDIDKALDADVDAIHVFIAASDIHLKYKL 122 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++YA+ G+ L + + GA + + D+ Sbjct: 123 RMTREEALRRAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDT 182 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G M + ++ + + K +H H++ L VANSIA +E G + ++ G+G Sbjct: 183 VGVMTPTRMKYLIKFILPAAKGRI-VSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIG 241 Query: 229 AGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALG 283 AGNA LE +AA + L + G + L + + + + P+ V + Sbjct: 242 ERAGNAALEEVVAALEFLLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHE 301 Query: 284 YAGV 287 Sbjct: 302 SGIH 305 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 229 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 70/324 (21%), Positives = 117/324 (36%), Gaps = 37/324 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ + D TLRDG + +L ++A+AL + VD IE +G Sbjct: 34 MTPDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKG------ 87 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E + A K + I L G A A R+ + + + Sbjct: 88 -----DFESVNEIAKNTKGSVICALARSGGVKDIAAAGEALAPAERKRIHNFISTSPLHM 142 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ AR L D T P+ L + + GAT I Sbjct: 143 KYKLRMEPETVLELITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTIN 202 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G D+ F L+ + + H H++L L VAN++A++ G +++ Sbjct: 203 IPDTVGYATPEDMEKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVEC 262 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVR 274 ++ G+G AGNA LE + A D+ + G L+ + L +Q Sbjct: 263 TINGIGERAGNAALEEIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAI 322 Query: 275 VDRETLALGYAGVYSSFLRHCETA 298 V R A L++ T Sbjct: 323 VGRNAFAHESGIHQDGVLKNAATY 346 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 115/320 (35%), Gaps = 36/320 (11%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN + + I D TLRDG ++E IA+ LD VD+IE Sbjct: 10 MNLPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGF----------- 58 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT----- 114 + ++ I ++ A I L D+ A G + + Sbjct: 59 PAASPGEMNSIRRIVELGLEANICGL---ARVLREDIDAAIDCGVDYIHTFIGTSPLHRE 115 Query: 115 ---------EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 D + ++YA E G+ + T + L + + E GA I V Sbjct: 116 YKLKMSPDEIIDRAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINV 175 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G M + LK EL+ +H H++ L VANS+AAVE G ++ A++ Sbjct: 176 PDTVGVMIPRAMNHLVSRLKEELR--VPISVHCHNDFGLAVANSLAAVEAGASQVHATVN 233 Query: 226 GMGAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETL 280 G+G AGNA LE + A + L++ ++ + + + V Sbjct: 234 GLGERAGNAALEEVVMALITRYDLPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAF 293 Query: 281 ALGYAGVYSSFLRHCETAAA 300 A L ET Sbjct: 294 AHEAGIHVHGVLEKAETYEP 313 >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 69/324 (21%), Positives = 123/324 (37%), Gaps = 42/324 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG A++ S++ QIA AL+ VD +EV G Sbjct: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 D E ++ A +K++++ L D+ A++A A R+ T + + Sbjct: 54 ---DFESVQTIARQIKNSRVCGL---ARCVEKDIDAAYEALRVADAYRIHTFLATSPMHI 107 Query: 121 ----------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + I+ AR D T ++L + + GAT I Sbjct: 108 ATKLRSTLPEVIERAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + + F AL+A + + +H H +L + V N++AAV G +I+ Sbjct: 168 IPDTVGYTLPYEYANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEG 227 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVR 274 ++ G+G AGN LE I A + + + + + P+ Sbjct: 228 AMNGLGERAGNCALEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAI 287 Query: 275 VDRETLALGYAGVYSSFLRHCETA 298 + A L++ E Sbjct: 288 IGSNAFAHSSGIHQDGVLKNRENY 311 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 122/319 (38%), Gaps = 36/319 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I+D TLRDG A + + IA LD V IEV Sbjct: 1 MNS-SITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVG------------- 46 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A +E EA ++ A LL D+ + + G + + ++ ++ ++A Sbjct: 47 IPAMGAVET-EAIRAMLSLGLRAHLLGWNRAVPSDILASIRCGLKRIHISVPVSDRQIAA 105 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + ++ A E G+ + T+ E + + A++ + +G Sbjct: 106 KFQGDRPRLLRQLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYC 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + R L + + MH H +L + AN++A + G ++ ++ G Sbjct: 166 DTVGVLDPFSTYKQIRRLVRAI--DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNG 223 Query: 227 MGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLA 281 +G AGNAPLE + A LG G D L + + + R PL V A Sbjct: 224 LGERAGNAPLEEVVMALRCTLGIDVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFA 283 Query: 282 LGYAGVYSSFLRHCETAAA 300 + LR +T Sbjct: 284 HESGIHAAGVLRDPQTYEP 302 >UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001788D72 Length = 321 Score = 227 bits (578), Expect = 5e-58, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 123/267 (46%), Gaps = 7/267 (2%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSSFNYGFGAH 64 I D T+RDG +S+E V+ + L++A VD +E+ + + + + G Sbjct: 8 KIVDCTIRDGGLVNNWDFSVEFVQNLYAGLNEAGVDYMEIGYKNSPKLLKGADQAGPWRF 67 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D E++ K++ L+ G D+ ++ ++RVA + + D + +Q Sbjct: 68 LDDEFLREVIPHKGKTKLSALVDIGRVDEDDILPREESLLDLIRVACYIKDVDKALALVQ 127 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 + G +T +M L + +++ +Y+VDS G+++ D+ Sbjct: 128 TFHDRGYETTLNIMALSNVMENELLEAFEMIRESVVDVVYIVDSYGSLDHKDMEYLVNKF 187 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 K L P + G+H H+N+ L +N++ A + G + +DAS+ GMG AGN P E+ + Sbjct: 188 KTHL-PNKRLGVHTHNNMQLAFSNTLVAADLGVELLDASVYGMGRAAGNCPTELLVTHLK 246 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDR 271 +L ++D + + PL+++ Sbjct: 247 G----TKYELRPVLDIIERFMIPLREK 269 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 227 bits (578), Expect = 6e-58, Method: Composition-based stats. Identities = 75/369 (20%), Positives = 130/369 (35%), Gaps = 52/369 (14%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG + + + IA+ L VD IE + Sbjct: 89 VRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGF-----------PAASKD 137 Query: 66 DLEWIEAAADVV-----KHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADV 118 D E ++ A+ V ++ + + D++ AW A A+ R+ T +D+ Sbjct: 138 DFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDI 197 Query: 119 SAQ----------------HIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGAT 161 + +++AR LG + V F + + E L + + GAT Sbjct: 198 HLEYKLKKTKAEVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGAT 257 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + + D+ G S+ LKA H ++L L AN+++ G + Sbjct: 258 TLNIPDTVGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQ 317 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKL------GWQHGTDLYALMDAADDLVR----PLQ 269 ++ ++ G+G AGNA LE + A G G D ++ + + Q Sbjct: 318 MEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQ 377 Query: 270 DRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAV-DILVELGKRRMVGGQED 324 V A L+H T GL D + LGK +D Sbjct: 378 PHKAIVGANAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKD 437 Query: 325 MIVDVALDL 333 + +V +L Sbjct: 438 RLTEVHSNL 446 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 227 bits (578), Expect = 6e-58, Method: Composition-based stats. Identities = 74/371 (19%), Positives = 131/371 (35%), Gaps = 52/371 (14%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + + + IA+ L VD IE + Sbjct: 87 VRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGF-----------PAASKD 135 Query: 66 DLEWIEAAADVV-----KHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADV 118 D E ++ A+ V ++ + + D++ AW+A A+ R+ T +D+ Sbjct: 136 DFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDI 195 Query: 119 SAQ----------------HIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGAT 161 + +++AR LG + V F + + E L + + GAT Sbjct: 196 HLKYKLKKSKEEVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGAT 255 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + + D+ G S+ +KA H ++L L AN+++ G + Sbjct: 256 TLNIPDTVGITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQ 315 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKL------GWQHGTDLYALMDAADDLVR----PLQ 269 ++ ++ G+G AGNA LE + A G G D ++ + + Q Sbjct: 316 VEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQ 375 Query: 270 DRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAV-DILVELGKRRMVGGQED 324 V A L+H T GL D + LGK +D Sbjct: 376 PHKAIVGANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKD 435 Query: 325 MIVDVALDLRN 335 + ++ L + Sbjct: 436 RLNELGYVLDD 446 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 126/341 (36%), Gaps = 47/341 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +KL I D TLRDG A ++E ++AK L+ VD IE +G Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKG--------- 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV--VRVATHCTEADVSAQ 121 D E + A VK++ + +L D++ A +A A R+ T + + + Sbjct: 63 --DFEAVNEVAKEVKNSTVCSL---ARALHSDIERAGEALAPAERKRIHTFIATSPIHME 117 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + +Q+AR D + + E L + + + GA I V Sbjct: 118 YKLRMTPEQVLERAVDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINV 177 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + + +H H++L L VANS+ AV+ G ++ ++ Sbjct: 178 PDTVGYAVPEEFGQLISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHST 237 Query: 224 LAGMGAGAGNAPLEVFIAAADKLG-----WQHGTDLYALMDAADDLVR----PLQDRPVR 274 + G+G AGNA LE + A + + + L R +Q Sbjct: 238 INGIGERAGNAALEEVVMAIKVRKDYFKDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAI 297 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV 311 V A L ET A G+ + I++ Sbjct: 298 VGDNAFAHEAGIHQHGLLAKRETYEIMKAEDVGVPSSKIVL 338 >UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK Length = 534 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 82/338 (24%), Positives = 140/338 (41%), Gaps = 35/338 (10%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 D TLRDG + +S + Q A+ A + +IE+ L+ SSF+ G A++ Sbjct: 4 LDCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELGL-RSLKNSSFS-GACAYTTDA 61 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHDL----------KNAWQAGARVVRVATHCTEADV 118 ++ D+ I ++ + A ++ +VR+A H E Sbjct: 62 FLSTL-DLPPSMTIGVMVNGSELVGKNAGQQALQLLFPSPASESPVDLVRIACHVHEFAE 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + + +E G D LM + + AKL Y +Y DS G+M+ D Sbjct: 121 ALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAA 180 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 + L++E + G+H H NL L ++N++ A++EG +D+++ GMG G GNA E Sbjct: 181 QIIQWLRSEW--QGALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEE 238 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETA 298 + +L LM + +P+Q + G+ +L Sbjct: 239 LAIEIAAR-TRKPANLIPLMTLLREHFKPMQ----------VKYGWGTNPYYYL------ 281 Query: 299 AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A +YG+ I LG R G+ED++ + LRN Sbjct: 282 AGKYGIHPTYIQEMLGDSRF--GEEDILAVIEY-LRNE 316 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 34/260 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG + +L +IA+ L+ VD IE +G Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV--VRVATHCTEADVSAQ 121 D + ++A A V++ + L D+ AW+A R+ + + Q Sbjct: 53 --DFQAVQAIAQTVRNCSVTGL---SRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQ 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + ++YA++ + + LA + + GA I + Sbjct: 108 YKLRMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINI 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + D F LK ++ + H H +L + VANS+AA+E G +I+ + Sbjct: 168 PDTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGT 227 Query: 224 LAGMGAGAGNAPLEVFIAAA 243 + G+G AGNA +E A Sbjct: 228 INGIGERAGNAAIEEVAVAL 247 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 78/367 (21%), Positives = 138/367 (37%), Gaps = 50/367 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ D TLRDG + + + IAK L+ V+ IE +G Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVSAQ 121 D ++ A +K+ +A L G D+ AW+A V R+ +D+ + Sbjct: 53 --DFLGVQEIARTIKNCSVAGLARCVKG---DIDAAWEALKDGVEPRLHVFIATSDIHLK 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 H ++YA+E + T + LA+ + + GA+ I + Sbjct: 108 HKLKKTREEVVEQAVAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINL 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + F+ +K + H H +L + VANS+AA+E G D+I+ + Sbjct: 168 PDTVGYLAPKEYGNIFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETA 227 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRP----LQDRPVRV 275 + G+G AGNA LE A D + L + +D + + + V Sbjct: 228 VNGIGERAGNAALEEIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVV 287 Query: 276 DRETLALGYAGVYSSFLRHCETAAARYGLSAVDI-----LVELGKRRMVGGQEDMIVDVA 330 A FL+ T +S + ++ LGK +D + + Sbjct: 288 GNNAFAHESGIHQDGFLKEKTTYEI---ISPELVGVTTDVLVLGKHSGRHAFKDRMKTLG 344 Query: 331 LDLRNNK 337 L + Sbjct: 345 FKLTEEE 351 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 120/357 (33%), Gaps = 40/357 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I D TLRDG + SL+ +IA+AL VD IE Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPM--------- 55 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ-- 121 + E + A VK IA L I A + A R+ + + V Q Sbjct: 56 --EFEAVRRIATEVKGPIIAALARTHTLDIDQAAKALEK-AEKPRIHVFTSASKVHLQYM 112 Query: 122 --------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 ++YAR D E + + ++ GAT I + D Sbjct: 113 LRKTEEEVLEMADRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPD 172 Query: 168 SGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + R ++ E+ + H H +L + AN++A VE G +I+ ++ Sbjct: 173 TTGYGTPQEYGALIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTIN 232 Query: 226 GMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGN LE + A D + + + + R P+ V Sbjct: 233 GIGERAGNCALEEVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGD 292 Query: 278 ETLALGYAGVYSSFLRHCETAA--ARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 A ++H T + ++ LGK + + D+ Sbjct: 293 NAFAHESGIHQDGVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYK 349 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 224 bits (570), Expect = 5e-57, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 135/377 (35%), Gaps = 59/377 (15%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG + + +IA+ L RVD +EV + Sbjct: 85 VRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSE-----------E 133 Query: 66 DLEWIEAAADVVKH------AKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEAD 117 + E I+ A V + + + D++ W+A A+ RV + ++ Sbjct: 134 EFEAIKTIAKTVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSE 193 Query: 118 VSAQH----------------IQYARELGMDTVGFLMMSHMTTP-ENLAKQAKLMEGYGA 160 + ++ ++YA+ LG + F T + + K GA Sbjct: 194 IHMKYKLKKTKEEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGA 253 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCD 218 T + D+ G + + + + +H H++L + AN+I+ + G Sbjct: 254 TTVGFADTVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGAR 313 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAADKL------GWQHGTDLYALMDAADDLVR----PL 268 +++ ++ G+G +GNAPLE + A G D +M + + + Sbjct: 314 QVEVTINGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYV 373 Query: 269 QDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDI-LVELGKRRMVGGQ----- 322 Q V L++ T LS D+ +V+ +V G+ Sbjct: 374 QPHKPIVGDNCFVHESGIHQDGILKNRSTYEI---LSPEDVGIVKSENSGIVLGKLSGRH 430 Query: 323 --EDMIVDVALDLRNNK 337 +D + ++ ++ + K Sbjct: 431 AVKDRLKELGYEISDEK 447 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 224 bits (570), Expect = 5e-57, Method: Composition-based stats. Identities = 79/362 (21%), Positives = 137/362 (37%), Gaps = 44/362 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG + + E +IA+ L+ RVD IE ++ Sbjct: 5 LIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGF-----------PAASNG 53 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ---- 121 D E ++A A +K + I L G I A + GA R+ T + + + Sbjct: 54 DFEAVKAVAAAIKGSTICGLARAIEGDIRRAGEALR-GANSARIHTFIATSPIHMEKKLR 112 Query: 122 ------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +++AR+ D + + L + + + GA + + D+ Sbjct: 113 MSPDQVVEQAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTV 172 Query: 170 GAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + R L+ + + +H H++L L VANS++AV G +++ ++ G+ Sbjct: 173 GYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGL 232 Query: 228 GAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRET 279 G AGNA LE + A D ++ A+ + P+Q V Sbjct: 233 GERAGNASLEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANA 292 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 A L+H ET A G A +L LGK + ++ ++L + Sbjct: 293 FAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLL--LGKHSGRNAFRSRLAELGIELES 350 Query: 336 NK 337 + Sbjct: 351 EE 352 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 223 bits (568), Expect = 8e-57, Method: Composition-based stats. Identities = 84/365 (23%), Positives = 138/365 (37%), Gaps = 44/365 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+++ I D TLRDG + +L Q+A+AL D VD IE Sbjct: 5 GQRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFA-----------AA 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC--------- 113 + DLE I+A V+ +A+L G D++ +W+A A R H Sbjct: 54 SPGDLEAIQAVGRQVEGPIVASLSRCNKG---DIEASWKALADAPRRRCHVFLATSPIHR 110 Query: 114 ---------TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 S ++ ARE D S T E LA+ + + G + Sbjct: 111 DFKLKLAKDEIIKRSVDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVN 170 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G S + R L+ ++ + +H H++L + VANS+A V EG +++ Sbjct: 171 IPDTVGYALPSTYAETIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVEC 230 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVR 274 ++ G+G AGNA LE + A LG G L + + + +Q Sbjct: 231 TINGIGERAGNASLEEIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAI 290 Query: 275 VDRETLALGYAGVYSSFLRHCETAA--ARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 V + A L + ET + + LGK +D ++ + Sbjct: 291 VGQNAFAHEAGIHQHGMLTNRETYEIMRPEEVGFARSQLVLGKHSGRHALKDRLLALGYQ 350 Query: 333 LRNNK 337 L + Sbjct: 351 LDEAQ 355 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 222 bits (567), Expect = 9e-57, Method: Composition-based stats. Identities = 76/339 (22%), Positives = 121/339 (35%), Gaps = 42/339 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+++I D TLRDG A S E IAK L D VD IE G Sbjct: 2 TKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA-- 120 D ++ + V +I I A QA R R+ + + + Sbjct: 54 ---DFMAVQRISQEVHGVEICGFARAVKEDIDAAVRATQAAERR-RLHMFLSSSSIHLDF 109 Query: 121 -------QHIQYAREL------GMDTVGF-LMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 Q I+ ARE+ +D F M + T E L + + GAT I + Sbjct: 110 QLRKSREQVIKIAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIP 169 Query: 167 DSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + F + + + + H H++L L VANS+AA+ G +++ ++ Sbjct: 170 DTVGYALPEEYGAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTV 229 Query: 225 AGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVD 276 G+G AGN LE + A + L + + + + R P+ V Sbjct: 230 NGVGERAGNCSLEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVG 289 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV 311 R L+ T G+ I++ Sbjct: 290 RNAFQHEAGIHQDGLLKERSTYEIMDPESLGVPRNMIIL 328 >UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA Length = 491 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 116/314 (36%), Gaps = 35/314 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + + +IAK LD+ VD IE +G Sbjct: 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKG----------- 51 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E I+ +A+I + + D+ A + V + + + Sbjct: 52 EREGIKLITKEGLNAEICSFV---RALPVDIDAALECDVDSVHLVVPTSPIHMKYKLRKT 108 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + ++YA+E G+ + + L K E GA + V D+ G Sbjct: 109 EDEVLETALKAVEYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGV 168 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + ++ F+ + + +H H++ + AN+ +AV G + ++ G+G A Sbjct: 169 LTPQKSQELFKKITENV--NLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERA 226 Query: 232 GNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 GNA LE +AA L G+ + L + + + R P+ V A Sbjct: 227 GNASLEEVVAALKILYGYDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGI 286 Query: 287 VYSSFLRHCETAAA 300 +++ ET Sbjct: 287 HVDGLIKNTETYEP 300 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 118/324 (36%), Gaps = 39/324 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + +Y D TLRDG + +L+ ++A L+ VD +E G Sbjct: 1 MNNR-VYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPG------ 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E ++ A ++A L G I A + AR R+ + + + Sbjct: 54 -----DFESVQRIAAQAGDIQVAGLARCVAGDIDRCWEAIK-NARNPRIHIFLSTSPLHM 107 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 +H ++ + + PE L + + + GAT + Sbjct: 108 RHKLRKDPDDVLRMAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTVN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G ++ R + + + +H H++L L VAN++AA G + + Sbjct: 168 LPDTVGYAQPAEYAARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAEV 227 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMD----AADDLVRPLQDRPVR 274 +L G+G AGNA LE + D G +H L + + +P+ + Sbjct: 228 TLNGIGERAGNASLEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNKAI 287 Query: 275 VDRETLALGYAGVYSSFLRHCETA 298 V A L++ ET Sbjct: 288 VGANAFAHESGIHQDGMLKNRETY 311 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 119/322 (36%), Gaps = 40/322 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I D TLRDG + + +IA+ L VD +E Sbjct: 8 PNQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGF-----------PIA 56 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + D E +E A V+ IA L +G I NA + +R R+ T + +D+ +H Sbjct: 57 SPGDFEAVETIARQVEGPVIAGLARIHVGDIDAAWNALRDASR-PRIHTFVSTSDIHIEH 115 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + +A++ D M + + E A+ ++ GAT I + Sbjct: 116 QMRSTREDVIGLTRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIP 175 Query: 167 DSGGAMNMSDIRDRFRALKAELKP---ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + L EL P + +H H +L L VANS A V G +++ + Sbjct: 176 DTVGYTMPHEYTAFLGRL-YELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECA 234 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR--------PLQDRPVRV 275 + G+G AGNA LE + G D A+ R +Q V Sbjct: 235 INGLGERAGNASLEEIVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIV 294 Query: 276 DRETLALGYAGVYSSFLRHCET 297 R A L++ ET Sbjct: 295 GRNAFAHESGIHQDGVLKNRET 316 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 221 bits (564), Expect = 2e-56, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 108/303 (35%), Gaps = 7/303 (2%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I D TLRDG A +++ +IA+ LD+ V+ IE+ G Sbjct: 16 PDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAAREM 75 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 V I L+ + H + S + Sbjct: 76 VSLGFSSELCGLARVVQKDIDALIDSDLSYAHLFIGTSPLHRDYKLKKSKTEILSQSMEM 135 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 ++YA++ G+ + T L + K +E GA I V D+ G + S R R Sbjct: 136 VEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTTRTLIR 195 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 L+ ++ +H H++ L V+NS+ +EEG ++ ++ G+G AGN LE + + Sbjct: 196 TLRKKI--NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTSLEELVVS 253 Query: 243 AD-KLGWQHGTDLYALMDAADDL----VRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 G D L D ++ + + V A L++ T Sbjct: 254 LKIAYGANLTVDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIHVDGILKNSST 313 Query: 298 AAA 300 Sbjct: 314 YEP 316 >UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q8KT71_PHOLU Length = 312 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 70/256 (27%), Positives = 111/256 (43%), Gaps = 2/256 (0%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 DVTLRDG + ++ E + +AL + V+ E+ + +G N G S Sbjct: 5 IDVTLRDGGYLNNFNFTTEYAIKHVEALTKSGVEWFEIGYRNGSFKPISNIGLTGMSPDS 64 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARE 128 +I V AK+ + P D+ G ++R+ + + AR Sbjct: 65 YIRDIHQSVPEAKLVVIAHPHNINADDIYAMKTNGVSLLRLCIKADNPQPCLELCEIARA 124 Query: 129 LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAEL 188 GM + + + + AK E GA IY+ DS G++ + F LK+ Sbjct: 125 TGMAVGINFTRASQLSISKIIEIAKQCEQAGADIIYLADSNGSLFPEQVAQMFYKLKSA- 183 Query: 189 KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGW 248 + Q G H H NL L ANSI A+ G + ID+SL+GMG GAGN LE +++ + Sbjct: 184 -TQVQLGFHPHDNLGLATANSIEAMRAGVNFIDSSLSGMGKGAGNLNLESWLSFLNLSQN 242 Query: 249 QHGTDLYALMDAADDL 264 DL + + ++L Sbjct: 243 SKQYDLERVFNQLNEL 258 >UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B5W6H6_SPIMA Length = 548 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 80/336 (23%), Positives = 136/336 (40%), Gaps = 22/336 (6%) Query: 1 MNGKKL--YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 MN L D TLRDG + + V A++ A VD +E+ L+ F Sbjct: 7 MNQPTLDFCFLDCTLRDGGYYNAWDFPRHIVIDYLNAMEAAGVDIVELGF-RSLKNQGFK 65 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLL--------LPGIGTIHDL--KNAWQAGARVVR 108 G A++ +++ + + + I ++ +P T+ L + A + R+VR Sbjct: 66 -GACAYTTDDFLRSL-PLPERLTIGVMVNGAELLGDMPLEQTLEHLFPETAATSPVRLVR 123 Query: 109 VATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 A H E + +E G LM P+ + ++ Y +Y DS Sbjct: 124 FACHIHEFQQVLPASTWLKERGFQVGFNLMQVADRLPQEIETLSQQACNYPLDVLYFADS 183 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G+MN + L+ + G+H H N+ + + N++ A+E G +DA++ GMG Sbjct: 184 MGSMNPQHTLEIINRLRTHW--QGALGIHTHDNMGMALQNTLQALEAGVTWLDATVTGMG 241 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLAL-GYAGV 287 G GNA E + Q L LM + RPLQ+ L G G+ Sbjct: 242 RGPGNAKTEYLALELGQRR-QKPCSLVRLMSLIEGFFRPLQNTHGWGTNTYYYLAGKHGI 300 Query: 288 YSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQE 323 + S+++ + S DIL + R+ GG++ Sbjct: 301 HPSYIQSMLGDS---RYSPEDILAVIEHLRVEGGKK 333 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 117/329 (35%), Gaps = 43/329 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + ++ I D TLRDG + S +A+ALD+ VD IE Sbjct: 7 ITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGF-----------P 55 Query: 61 FGAHSDLEWIEAAADVVKHAKI--ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 + SD + + ++ + A L I A +A A R+ + + + Sbjct: 56 ASSQSDRDAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAAN-PRLHVFLSTSPL 114 Query: 119 SAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 +H + AR D + T + L + ++ GAT Sbjct: 115 HREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATT 174 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKP-----ETQTGMHAHHNLSLGVANSIAAVEEGC 217 I + D+ G +IR+ F+ + A + H H++L L VANS+AA+E G Sbjct: 175 INLPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGA 234 Query: 218 DRIDASLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQ 269 +++ ++ G+G AGN LE + ++ + L R P+Q Sbjct: 235 RQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQ 294 Query: 270 DRPVRVDRETLALGYAGVYSSFLRHCETA 298 V A LRH T Sbjct: 295 RNKAIVGANAFAHESGIHQHGMLRHRGTY 323 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 68/338 (20%), Positives = 124/338 (36%), Gaps = 42/338 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG + E IA+ L VD IE G Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 + I+ + +++ +I I A Q A+ R+ + +D+ H Sbjct: 53 --EFAAIQQISRELQNVEICGFARAVKVDIDAAVKATQDAAKR-RLHLFISSSDIHLSHQ 109 Query: 123 ---------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 I YA++ + M S + + + + + GAT I + D Sbjct: 110 IRKTRSEVVQIARDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPD 169 Query: 168 SGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G +++ D F +++ + + + H H++L + VANS+AAV+ G +++ ++ Sbjct: 170 TLGYALPNEMVDLFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVN 229 Query: 226 GMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGN LE + L + + + + + R P+ V R Sbjct: 230 GVGERAGNCSLEELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGR 289 Query: 278 ETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV 311 L+ T G+S I++ Sbjct: 290 NAFQHESGIHQDGLLKDRSTYEIMDPEAMGISRSMIIL 327 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 219 bits (559), Expect = 9e-56, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 110/285 (38%), Gaps = 33/285 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K +YI D TLRDG ++ E +IA+ LD+ + IE + Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSER--------- 72 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS---- 119 + + ++ A+ +A I L D+ A + + + + Sbjct: 73 --EADIVKTIANEGLNADILALC---RALKKDIDKAIECDVDGIITFIATSPLHLKYKFN 127 Query: 120 -----------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++YA+E G+ + T E+L K K E GA +++ D+ Sbjct: 128 NKSLDEILEMGVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADT 187 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + LK LK G+H H++ V NSI + G + ++ G+G Sbjct: 188 TGCATPQSMEFICKTLKENLKK-AHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIG 246 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPV 273 AGNA LE I A L + DL ++ +L R +++ Sbjct: 247 ERAGNAALEELIMALTVL---YDVDLGLNLEVLPELCRMVEEYSG 288 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 219 bits (559), Expect = 1e-55, Method: Composition-based stats. Identities = 69/369 (18%), Positives = 134/369 (36%), Gaps = 48/369 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +K+ + D TLRDG + ++ +IAK L VD IE Sbjct: 1 MGDRKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGF-----------P 49 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADV 118 ++ + E ++ A+ + +A L D+ ++A A+ R+ +D+ Sbjct: 50 AASNGNFEAVKHIAENIDDVVVAGL---SRCVKSDIDKTYEALKNAKKSRIHLFIATSDI 106 Query: 119 SAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 ++ ++YA + + T + L K + GA Sbjct: 107 HLKYKLKISRDEALKMAVDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKI 166 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G + +K + K +H H++L + V NS++A+E G D++ Sbjct: 167 INIPDTVGYAVPKEFEKLVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQV 226 Query: 221 DASLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRP 272 + ++ G+G AGNA LE I A + H + + + LQ Sbjct: 227 EVTVCGIGERAGNASLEEVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNK 286 Query: 273 VRVDRETL----ALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVD 328 V + GV ++ + G++ I +GK E + + Sbjct: 287 AIVGSNAFRHTAGIHQHGVINNKATYEIMRPEDIGITTDHI--SMGKLSGRNAFELKLKN 344 Query: 329 VALDLRNNK 337 + +L ++ Sbjct: 345 MGYELSRDE 353 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 66/368 (17%), Positives = 133/368 (36%), Gaps = 49/368 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+Y+ D TLRDG + + E IAK L+ RVD +E QG Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA----RVVRVATHCTEADVS 119 D E + + +K + + L G D+ +++ ++ + + ++ Sbjct: 53 --DFEAVREISRQIKDSSVVAL---GRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHIT 107 Query: 120 AQH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + + YA+ L + + E + + + + GATC+ + Sbjct: 108 KKFNKNPEDILQMGVDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNI 167 Query: 166 VDSGGAMNMSDIRDRFRALK---AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ G + + P +H H++ L AN++AAV G ++++ Sbjct: 168 PDTVGFAVPELFGGLIHQIYDRLQNVAPHVLLSVHCHNDSGLATANTLAAVRNGANKVEC 227 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRPL----QDRPVR 274 ++ G+G AGN LE + + + A+ + + + R + Q Sbjct: 228 TINGIGERAGNTSLEEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKAL 287 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV--ELGKRRMVGGQEDMIVD 328 V A L+ E + G +DI++ GK + + + Sbjct: 288 VGENAFAHSSGIHQDGLLKSKEVYEIFEPSDIGAPPMDIVLTARSGKHAFEYISKKLGYE 347 Query: 329 VALDLRNN 336 +A ++ N Sbjct: 348 IAPEVLNE 355 >UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Bacteroides vulgatus ATCC 8482 RepID=A6L7H4_BACV8 Length = 525 Score = 218 bits (555), Expect = 3e-55, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 134/326 (41%), Gaps = 13/326 (3%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + ++ +R+I + L A +D +E + + F A Sbjct: 3 KIQLLDCTLRDGGYINNFRFGKYAIRKILQQLTHAGLDIVECGFLEDGEYDEDTSIFNAA 62 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 + + + ++ G + L + +RV H E + + ++ + Sbjct: 63 EQIASL--LPNEHGRTMFVAMVCYGEYDLSQLSPCTRNSIDGIRVTFHYDEVEGALEYCR 120 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 +E G + + T L + + Y+VD+ G M+ +DI F + Sbjct: 121 EIKEKGYKVFVQPVGTSSYTDIQLLHLIEKVNELQPYSFYLVDTLGLMHKNDIARFFYLI 180 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI---DASLAGMGAGAGNAPLEVFIA 241 L G H+H+NL L +NS E DR+ DAS+ GMG GAGN E+ Sbjct: 181 NTNLDKSINMGFHSHNNLQLSFSNSQEFFEYVGDRVISLDASIYGMGRGAGNLNTELIAN 240 Query: 242 AA-DKLGWQHGTDLYALMDAADD---LVRPLQDRPVRVDRETLAL-GYAGVYSSFLRHCE 296 D+ G + + L++ D+ +R + V A+ G Y+S+L + Sbjct: 241 YVNDREGHMYAIE--PLLEVVDEFIIHIRQKHEWGYTVPYYLAAINGCHPNYASYLAQKQ 298 Query: 297 TAAARYGLSAVDILVELGKRRMVGGQ 322 T A + +SA+ ++ + KR + + Sbjct: 299 TLAVK-EISAILHMIPVEKRSLYNKE 323 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 217 bits (554), Expect = 3e-55, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 126/326 (38%), Gaps = 43/326 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN ++ I D TLRDG A++ S++ QIA +L++ +D IEV G Sbjct: 1 MNS-QVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPG------ 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTE--- 115 D + ++ + +K+++I +L D+ A +A + R+ Sbjct: 54 -----DFKSVQTISKNIKNSRICSL---ARCLDKDIDAAAEAMHSSNAFRIHIFLATSIL 105 Query: 116 -------------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 D++ ++ A D + TT +NL + + + G Sbjct: 106 HMESKLKKNFDQIIDMAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKT 165 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G +++ L + ++ +H H++L + V NSI+A++ G +I Sbjct: 166 INIPDTVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQI 225 Query: 221 DASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRP 272 + ++ G+G AGN LE I A D LG + + + + P+ Sbjct: 226 EGTINGIGERAGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNK 285 Query: 273 VRVDRETLALGYAGVYSSFLRHCETA 298 V A L++ + Sbjct: 286 AIVGSNAFAHSSGIHQDGVLKNRKNY 311 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 217 bits (553), Expect = 5e-55, Method: Composition-based stats. Identities = 67/370 (18%), Positives = 130/370 (35%), Gaps = 50/370 (13%) Query: 1 MNGKK-LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 +N K ++I D TLRDG Q + Q+A++L+ VD IE G Sbjct: 5 LNEKNSVFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPG----- 59 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEAD 117 D + + V I L D+ A ++ A+ R+ T + Sbjct: 60 ------DFNSVIEISKSVTWTIICALT---RAIEKDIDIAAESLQYAKRKRIHTGIGTSP 110 Query: 118 VSAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT 161 ++ ++YA++ D + + T LA+ + + GA Sbjct: 111 YHIKYKFNSTQDEILERAVASVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAK 170 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + + D+ G + + + L +K H H++L + AN+I+ + G + Sbjct: 171 VVNIPDTTGYCLPEEYGAKIKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQ 230 Query: 220 IDASLAGMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLV----RPLQDRP 272 ++ ++ G+G AGN LE + +L + + + + P+Q Sbjct: 231 VEVTINGIGERAGNTSLEEVVMIIKSHKELNIGTNINTKHIYPISRMISSLMNMPVQPNK 290 Query: 273 VRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDI-----LVELGKRRMVGGQEDMIV 327 V R A L++ E + DI ++ L R + + Sbjct: 291 AIVGRNAFAHSSGIHQDGILKNRENYEI---IDPKDIGIDNNIIALTARSGRAALKYRLN 347 Query: 328 DVALDLRNNK 337 + ++L K Sbjct: 348 ILGIELSQKK 357 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 216 bits (551), Expect = 7e-55, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 124/333 (37%), Gaps = 41/333 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K+ I+D TLRDG A ++LE IAK LD V +EV Sbjct: 1 MN--KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVG------------- 45 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A + E + A + A LL I D+K + G V +A + ++A Sbjct: 46 IPAMGEEE-MRAICAISNLGLKANLLAWNRAVISDIKASVACGMERVHIAIPVSGIQIAA 104 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + I +A + G+ S L A + +GA+ Sbjct: 105 KFHGQWRVSLQRLKDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFC 164 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + + L + L +H H++ + AN++A ++ G ++ ++ G Sbjct: 165 DTVGVLDPFTTYGKVKLLVSALT--IPVEVHTHNDFGMATANALAGIKAGASSVNTTVIG 222 Query: 227 MGAGAGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLA 281 +G AGNA LE + A ++ G G D L++ + + + V T A Sbjct: 223 LGERAGNAALEEVVMAIKRIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFA 282 Query: 282 L----GYAGVYSSFLRHCETAAARYGLSAVDIL 310 GV + + A G ++ Sbjct: 283 HESGIHAHGVLQNPDTYEPFAPEEVGWERRLVV 315 >UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C68 RepID=D0ANI5_ENTFC Length = 527 Score = 216 bits (551), Expect = 7e-55, Method: Composition-based stats. Identities = 71/340 (20%), Positives = 139/340 (40%), Gaps = 16/340 (4%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I D TLRDG + ++ +N ++I L ++ ++ IE + +N Sbjct: 1 MN--NVQILDCTLRDGGYCNNWEFGFDNTKKIISGLIESGIEIIECGFLT--NKTVYNKN 56 Query: 61 FGAHSDLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 ++ LE + + K+ ++ G I DL + + +R+A H + + Sbjct: 57 VTKYTTLEELAQIIPEKREGKLFVAMMNYGEYNIEDLPDYDGSSIDGIRIAFHKKNCNEA 116 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 + + ++ G M+S T E K + + Y+VDS G M D+ Sbjct: 117 LKLCREIKKKGYLVFVQAMVSLNYTDEEFLAVIKNVNQFKPYAFYIVDSFGMMKGKDLTR 176 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPL 236 F ++ L+ + Q G H+H+N+ L +N+ + +R ID+S+ GMG GAGN Sbjct: 177 LFYMIEHNLEKDIQIGFHSHNNMQLAYSNAQKLITVQTNRSLIIDSSVYGMGRGAGNLNT 236 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR----VDRETLALGYAGVYSSFL 292 E+F+ + + L L+ D+++ + + + Y+S+L Sbjct: 237 ELFVEYLNDNAGKK-YQLKPLLYIIDEILNSFYQKSYWGYSLPNYISAVHNAHPNYASYL 295 Query: 293 RHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 + T +I + + + V + I D+ Sbjct: 296 SYKNTLTIEA---MNEIFEMMDEEKKVSYDKQYIEDLYYK 332 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 216 bits (550), Expect = 9e-55, Method: Composition-based stats. Identities = 83/365 (22%), Positives = 136/365 (37%), Gaps = 48/365 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + S+E +IA L +VD IE + Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGF-----------PITS 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSAQ 121 D E + A V+ IA L D++ AW+A +R R+ T +D+ + Sbjct: 51 EGDFEAVSRIASEVEGPVIAGL---ARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIE 107 Query: 122 H----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 H ++ A+ L + M + T LA+ GA I + Sbjct: 108 HQMRSTREEILSGAAEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINI 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQ--TGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G ++ R LK + + +H H +L + VANS+A VE G +++ + Sbjct: 168 ADTVGYTTPAEFAAFLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVA 227 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 + G+G AGNA LE + A D G + G + L + + + + V Sbjct: 228 VNGIGERAGNASLEEVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVV 287 Query: 276 DRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 R L+ T A GL +I LGK ++ + D+ Sbjct: 288 GRNAFLHESGIHQDGVLKDRRTFEIMKPADIGLEGTNIF--LGKHSGRHALKEALADLGY 345 Query: 332 DLRNN 336 L Sbjct: 346 TLEGE 350 >UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legionella pneumophila RepID=Q5ZS38_LEGPH Length = 295 Score = 216 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 5/264 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I D +LRDG H + +++++I LD++ ++ IE+ + +G N G Sbjct: 1 MNP--VSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIG 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 +++ ++K AKIA ++ P DL G +++R+ + + Sbjct: 59 KAGMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAV 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I+ A+ L +T ++ T L + + + IY DS G++ I Sbjct: 119 PLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDMIYFADSNGSLFPDRINCL 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 ++ + K G HAH NL L AN++AAV G IDASLAGMG G GN E FI Sbjct: 179 YKKYTRQYK--VSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFI 236 Query: 241 AAADKLGWQHGTDLYALMDAADDL 264 A + +L ++ AA+ + Sbjct: 237 AYLHANNIKK-YNLEDVLTAANYV 259 >UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJA2_FIBSS Length = 313 Score = 216 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 126/287 (43%), Gaps = 16/287 (5%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNY 59 M + + + D T+RDG +H +SLE VR++ L A VD +E+ + + + Y Sbjct: 1 MYYETIKVLDCTIRDGGLVNKHDFSLEFVRRLYTLLTAAGVDYMEMGYKNSPELFDPKEY 60 Query: 60 GFGAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 G D + + D + K+A + G + +K A ++ ++ RVA++ D Sbjct: 61 GPWKFCDDDLLWKVKDGIDSKMKMAVMADVGRVNMDAVKPASESPYQMFRVASYVKNIDK 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHM-TTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + ++G +T +M PE ++ E A +Y+VDS GA DI Sbjct: 121 GISMVNAFHDMGYETTLNIMAVSRDRGPELDEALHQVNEECKADVLYLVDSFGAFYQEDI 180 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 K + + G H H+N L +N+I A+ D +D S++GMG GAGN E Sbjct: 181 DKELARYKG-IVKNKKFGFHGHNNQQLAFSNTIQAIINHVDYLDGSVSGMGRGAGNCTTE 239 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY 284 + + + DL ++DA +L PLQ + GY Sbjct: 240 LLLGFLKNPKY----DLRPVLDAIQELFLPLQSK--------YEWGY 274 >UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7 Length = 492 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 113/314 (35%), Gaps = 35/314 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG S +IA LD+ V+ IE +G Sbjct: 2 VNIFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKG----------- 50 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E I+ A+ +A+I++ + D+ A V + ++ + Sbjct: 51 EREAIKLVAEQKLNAEISSFV---RALPVDIDAALSCNVDSVHLVVPTSDLHMEYKLRKT 107 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + YA+E G+ + + E L + K E A I + D+ G Sbjct: 108 REENLKDAMHAVDYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGI 167 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + + +KA + +H H++ + AN+++A+ G D+ ++ G+G A Sbjct: 168 LTPVKSMELIKTMKAAVT--IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERA 225 Query: 232 GNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVRPLQ----DRPVRVDRETLALGYAG 286 GNA LE + + L + L + + + ++ V A Sbjct: 226 GNASLEEVVMSLKSLYDMETNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGI 285 Query: 287 VYSSFLRHCETAAA 300 ++ ET Sbjct: 286 HVDGLMKSTETYEP 299 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 119/324 (36%), Gaps = 42/324 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG A++ S++ QIA AL+ VD +EV G Sbjct: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 D E ++ A +K++++ L D+ A ++ A R+ T + + Sbjct: 54 ---DFESVQTIARTIKNSRVCAL---ARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHI 107 Query: 121 Q----------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ AR D + T +LA+ + GAT I Sbjct: 108 ATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + + L + + +H H +L + V N++AAV G +++ Sbjct: 168 IPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEG 227 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RPLQDRPVR 274 ++ G+G AGN LE I A + + + + + + P+ Sbjct: 228 AMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAI 287 Query: 275 VDRETLALGYAGVYSSFLRHCETA 298 V A L++ E Sbjct: 288 VGTGAFAHSSGIHQDGVLKNRENY 311 >UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synechococcus sp. WH 8102 RepID=Q7U935_SYNPX Length = 540 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 70/347 (20%), Positives = 131/347 (37%), Gaps = 39/347 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGS------ 55 N + I D TLRDG + +S E + +A A++D IE+ L Sbjct: 3 NERTFKILDCTLRDGGYYNNWNFSDELIENYVRASLAAKIDVIEIGFRSSLNNKFKGACA 62 Query: 56 ------SFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV 109 N F +D+ + +++ + I LL K A + +VR+ Sbjct: 63 YSSDLFLENLPFLNGTDIAVMVNGSEICRTDSIPRLLEKLFP-----KPAISSIVSIVRI 117 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 A H +E ++ + G +M ++ + + +Y DS Sbjct: 118 ACHFSELSRVLSATRWLADHGYKICINIMQISDRKYADIKEITSMASDCPIDVLYFADST 177 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G++ DI + + + G+H H+N+ + + N++ A EEG + +D++++GMG Sbjct: 178 GSLKPDDISRIVEWFRTGWQR--ELGIHTHNNMGIALQNTLRAYEEGVNWLDSTVSGMGR 235 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYS 289 G GNA E + + L + LM + + D+ G+ Sbjct: 236 GPGNAKTEELVIETETLR-DGNVNYVPLMALSRQ----------KFDKLKAQYGWGPHPY 284 Query: 290 SFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +L + +YG+ I + R ED+I V L++ Sbjct: 285 YYL------SGKYGIHPSYIQEMINDARYD--DEDIIA-VTNQLKSE 322 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 214 bits (545), Expect = 4e-54, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 120/304 (39%), Gaps = 19/304 (6%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG ++E IA+ALDD VD IE + F A Sbjct: 2 LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAGTAIAGEEE-----FRAVK 56 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------ADVS 119 ++ A++ A+I + + + A + + + T ++S Sbjct: 57 EIANAGLKAEICSFARIKEIDIDAVANADADSVFMVAPSSDIHIKTKFPNKSGDDIIEMS 116 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 + ++YA+E G+ S + + + GA + D+ G + Sbjct: 117 VKAVEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAEC 176 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R L +E H H++ L AN+I AV+ G I ++ G+G AGNAPLE Sbjct: 177 IMRELTSEF--NVPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEEV 234 Query: 240 IAAADKL-GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLA----LGYAGVYSSFLRH 294 + A + G + + D + LV L P+ +++ + + +G+++S L Sbjct: 235 VLALETFYGIKTKIRKEKIYDTS-KLVEALTRFPIALNKPIVGYNAFMHESGIHTSALLR 293 Query: 295 CETA 298 A Sbjct: 294 NAKA 297 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 214 bits (544), Expect = 5e-54, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 113/332 (34%), Gaps = 40/332 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +L+I D TLRDG Q + Q+AKAL+ VD IE G Sbjct: 2 SDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D + + + V I L I A + R R+ T +D ++ Sbjct: 54 ---DFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALRFAKRG-RIHTGIGTSDSHIKY 109 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +YA++ D + + T E LA+ + + GAT + + Sbjct: 110 KFNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIP 169 Query: 167 DSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + + + L + H H++L + AN++ V G +++ ++ Sbjct: 170 DTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTI 229 Query: 225 AGMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDR 277 G+G AGN LE + + + + P+Q V R Sbjct: 230 NGIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGR 289 Query: 278 ETLALGYAGVYSSFLRHCETAAARYGLSAVDI 309 A L++ +T + D+ Sbjct: 290 NAFAHSSGIHQDGVLKNAQTYEI---IDPKDV 318 >UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=C5S7B1_CHRVI Length = 327 Score = 213 bits (543), Expect = 6e-54, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 134/314 (42%), Gaps = 21/314 (6%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNYGF 61 +L + D T+RDG HQ+S + VR + +A +A +D +E+ + + + +G Sbjct: 11 RPELKVLDCTVRDGGLVNAHQFSDDFVRAVYRACVEAGIDYMEIGYKNSPKVFPKEKFGP 70 Query: 62 GAHSDLEWIEAAA----DVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEA 116 H D ++ K+A + G + A ++ ++RVA + + Sbjct: 71 WRHCDEADLKRVVGDHDPEKTGLKLAAMADAGKSDWETQIVPAAESPLSMIRVAFYAHQV 130 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + I+YA +LG +T LM T + + + AT + +VDS G + Sbjct: 131 SEAVDMIRYAHDLGYETTANLMAVSNITEAEIDTVLESIAPTPATTMVIVDSFGYLYREQ 190 Query: 177 IRDRFRALKAEL-KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 I +R + L + G+HAH+NL L AN+I A+ GC+R+DA++ G G GAGN Sbjct: 191 IDRLYRKYTSALEGTGKEIGIHAHNNLQLAFANTIEAIILGCNRVDATMYGFGRGAGNCH 250 Query: 236 LEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVY--SSFLR 293 E+ + ++ + +++ + PL R L G + Y + L Sbjct: 251 TELLLGFLRNPKFE----VRPVIEVIQKYLFPL--------RRELDWGPSIPYNLTGQLN 298 Query: 294 HCETAAARYGLSAV 307 +A + Sbjct: 299 QHPRSAIEWREGPT 312 >UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN Length = 576 Score = 213 bits (542), Expect = 8e-54, Method: Composition-based stats. Identities = 63/331 (19%), Positives = 111/331 (33%), Gaps = 46/331 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++L + D TLRDG + + + IA+AL VD E G Sbjct: 31 KERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPG-------- 82 Query: 63 AHSDLEWIEAAADVVK-------HAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHC 113 D + + A A + + T+ D++ + A A R+ T Sbjct: 83 ---DFDAVSAIAKEIGPITAGRPTGEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFL 139 Query: 114 TEADVSAQH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEG 157 +D+ Q+ +++A+ L D + + P+ L + Sbjct: 140 ATSDIHLQYKLKISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIK 199 Query: 158 YGATCIYVVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEE 215 GAT + + D+ G + F L + H H++L L AN++AAV+ Sbjct: 200 AGATTLNIPDTVGYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQG 259 Query: 216 GCDRIDASLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RP 267 G + + ++ G+G AGN LE + A D + + + Sbjct: 260 GARQAEVTINGIGERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMS 319 Query: 268 LQDRPVRVDRETLALGYAGVYSSFLRHCETA 298 +Q V A L+H T Sbjct: 320 IQPNKAIVGSNAFAHESGIHQDGVLKHQATY 350 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 99/259 (38%), Gaps = 31/259 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + +LE IA+ L VD IE F + Sbjct: 7 RVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGF-----------PFASQ 55 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV--RVATHCTEADVSAQH 122 D ++ A V + + + D+K A A R+ T +D+ +H Sbjct: 56 GDFSAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEH 115 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + YAR L D + + PE L + + GA I + Sbjct: 116 KLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIP 175 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G S+ + + E +H H++L L VAN + AV+ G + + ++ Sbjct: 176 DTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTI 235 Query: 225 AGMGAGAGNAPLEVFIAAA 243 G+G AGNA LE + A Sbjct: 236 NGIGERAGNAALEELVMAL 254 >UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FUY3_9FIRM Length = 431 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 130/300 (43%), Gaps = 10/300 (3%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + + D TLRDG + ++ +N+ I + L DA VD IE+ D F+ Sbjct: 3 NIRLLDCTLRDGGYVNDWKFGHDNLVGIFERLVDANVDIIEIGFLD--DRRPFDIDRSIM 60 Query: 65 SDLEWIEAAADVVKHAKIAT--LLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + E V+H + ++ G I +++ + +RV + ++ Sbjct: 61 PNTACAEKIWKDVEHKNVMVVGMIDYGTCDISNIQPCCDSFLDGIRVIFKEHLMKEAMEY 120 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + ++LG L+ T E++ + +L+ + +VD+ G + + + + + Sbjct: 121 CRQIKKLGYKVFAQLVSVTTYTKESMLELIELVNDVKPYAVSMVDTYGLLKPNTLLEYYE 180 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD----RIDASLAGMGAGAGNAPLEV 238 L + PE Q G HAH+N L AN++A V + +D +L GMG AGNAP+E+ Sbjct: 181 ILDEYVYPEVQIGFHAHNNFQLAYANALAFVSKPNKKHDIVVDGTLFGMGKSAGNAPIEL 240 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLAL-GYAGVYSSFLRHCET 297 + ++ + + A++++ ++ + ++ + L + S+L + E Sbjct: 241 LAMSLNE-DFNKNYQINAMLESVEESIMDFFEQSPWGYKMFFYLCALNKCHPSYLSYYEK 299 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 114/324 (35%), Gaps = 42/324 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ + D TLRDG A +++ +A L D VD IE G Sbjct: 9 PNRVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPG-------- 60 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 D E I A V +L D+ A +A R H A Sbjct: 61 ---DEEAIRTIAREVVGPTFCSL---SRALESDIDAAARALLPAKRKRCHIFLATSPIHR 114 Query: 117 ------------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 +++ + + YA + + + T + L + GA + Sbjct: 115 AAKLKKTREQVVEIAHKAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLN 174 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G +I F LKA LK P+ H H +L LGVAN++AA+E G +I+ Sbjct: 175 IPDTVGYTTPKEIYQIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEV 234 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRP----LQDRPVR 274 ++ G+G AGNA LE + A + G + L A+ L R + Sbjct: 235 TINGIGERAGNAALEEVVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAV 294 Query: 275 VDRETLALGYAGVYSSFLRHCETA 298 V R A L T Sbjct: 295 VGRNAFAHESGIHQHGMLTDARTY 318 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 211 bits (536), Expect = 4e-53, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 103/254 (40%), Gaps = 30/254 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + +S + +IA+ LD V+ IE G A Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIE-------------LGIPAM 49 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ--- 121 +E ++A + + A L + D++ + + + + ++ + + Sbjct: 50 GGIE-VDAISSIASLDLKARLTTWNRLHLSDIRASLSCRVKNLHICAPVSDIQIEYKLNK 108 Query: 122 -----------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 I+YA++ G + PE L + A L + GA + D+ G Sbjct: 109 SRLWVLDCLKRAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVG 168 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + LK +LK + H H++ L AN++AAV G ID ++ G+G Sbjct: 169 VLEPFSTYRELSWLKDKLK--IELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGER 226 Query: 231 AGNAPLEVFIAAAD 244 AGNA +E +AA Sbjct: 227 AGNANMEEVVAAIR 240 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 210 bits (535), Expect = 6e-53, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 102/290 (35%), Gaps = 9/290 (3%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I D TLRDG + +++ +IA L D VD IE S Sbjct: 26 KKRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKI 85 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D +I A I +++ GI IH + + + Sbjct: 86 HEMDGNFISLAR--CNRHDIDSVIDTGIDNIHLFIATSDIHIKYKLKTSRENIMEKIVDS 143 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I YAR G++ + + T L GA I + D+ G MN + + Sbjct: 144 IDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYNFIH 203 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K K +H H++ + AN++AA+ G D ++ G+G AGNA LE + + Sbjct: 204 EIKNRTKS--CISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALEEVVLS 261 Query: 243 ADKL-GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 G ++ + + + +Q V + Sbjct: 262 VHAFTDCSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIH 311 >UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legionella RepID=C6N5U6_9GAMM Length = 302 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 72/264 (27%), Positives = 118/264 (44%), Gaps = 4/264 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN KK+ + D +LRDG H + + +I ALD + ++ IE+ + +G N G Sbjct: 1 MN-KKIQLLDASLRDGGHRTNFHFQDGALEEILPALDRSGIEYIEIGYRNGSLHPINNLG 59 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E++ ++ +AK+A + P DL G ++R+ + Sbjct: 60 RAGWCDKEYLLFCRALILNAKMAVMAHPENVNQDDLLELKNCGVDLLRICIAKDHFSSAI 119 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I+ A+++G++ + T L IY DS G++ S I + Sbjct: 120 PVIKIAKQIGLEVSINFIHISYYTNAELDAVIAEASLQQPDIIYFADSNGSLLPSRINEI 179 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 + + G HAH N+ L AN++AA+ G IDASLAGMG G GN E FI Sbjct: 180 YDRYINQYA--IPFGFHAHDNIGLAQANALAAMNAGVHFIDASLAGMGKGTGNLKTEFFI 237 Query: 241 AAADKLGWQHGTDLYALMDAADDL 264 A + + DL+ ++ AA+ + Sbjct: 238 AYLHAINIKK-YDLHDILYAANYV 260 >UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MS84_9FIRM Length = 528 Score = 209 bits (533), Expect = 1e-52, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 122/303 (40%), Gaps = 17/303 (5%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG + ++ EN++ + L A +D IE + F+ Sbjct: 2 KRIRILDCTLRDGGYINNWKFGYENIKDTVRRLIQAGIDIIEAGYLSSKG--DFSADESQ 59 Query: 64 HSDLEWIEAAADVV-KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +S ++ I+ K+ IA ++ G L G +RV H ++A + + Sbjct: 60 YSSVDAIKRILPADRKNTLIAVMINCGDYDAELLPQYDGTGPDCIRVCFHKSQALQAVEL 119 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + +E G M++ + + + Y+VDS G+M D+ F Sbjct: 120 CRKIKEKGYKVYFQPMVALSYSDAEYLGLIGMANKFRPDGFYIVDSHGSMKQKDVARFFY 179 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVF 239 ++ L E G H+H+NL L +N+ D ID+S+ GMG GAGN E+F Sbjct: 180 LIENNLDKEIAVGFHSHNNLQLSYSNAQYLTALHTDHNLIIDSSIMGMGRGAGNLNTELF 239 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 + ++ ++ + D+ + + T A GY+ S +L Sbjct: 240 VEYLNETA-GADYSTEPILCSIDNTIARI--------YMTTAWGYS--LSGYLSAKYRCH 288 Query: 300 ARY 302 Y Sbjct: 289 QNY 291 >UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides RepID=C3PVE7_9BACE Length = 528 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 116/314 (36%), Gaps = 9/314 (2%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 D TLRDG + + + I K L+ A D IEV D F+ E Sbjct: 2 LDCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEVGFLD--DRREFDINRSIMPSTE 59 Query: 69 WIEAAADVVKHAKI--ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYA 126 I VK K ++ G ++ + + +RV + D + + Sbjct: 60 AINKIFGSVKKGKAIPVAMIDFGTCSLDSIGSCDSTFIDGIRVIFKKEKIDQALPFCKAI 119 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 +E G + + + + + +VD+ G ++ S + F + Sbjct: 120 KEKGYKLFIQAISITAYSDIEMLEYVNRINEIKPYAFSIVDTYGLLDNSSMARYFYLIDN 179 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIAAA 243 L P + G H H+N LG +N+I +E+ R D+++ GMG AGN E+ Sbjct: 180 NLDPSIKMGYHEHNNFQLGFSNTIKFLEKSTKRTLVADSTVYGMGKSAGNCASELLAMHL 239 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVR-VDRETLALGYAGVYSSFLRHCETAAARY 302 ++ H DL L++ D + P+ + + + S++++ + Sbjct: 240 NEYYGGH-YDLNQLLEIVDTDLMPIYQKHYWGYKYDFYIASMQRCHPSYVQYLLKKSTLS 298 Query: 303 GLSAVDILVELGKR 316 S +IL + + Sbjct: 299 VSSINEILSSIPEE 312 >UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVP8_9CLOT Length = 336 Score = 207 bits (527), Expect = 5e-52, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 127/305 (41%), Gaps = 19/305 (6%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K+++ D TLRDG + ++ ++I L + + IE+ + Sbjct: 1 MN--KIHLLDCTLRDGGYVNNWEFDNGVAKEIVNGLYKSGIHVIEIGIMGHGGKVGKSTK 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F + + E + + K K A +L D+ + ++R+A +E + Sbjct: 59 FASFKEAESL--LENRKKDCKYAIMLNQAEAASFDIPARSEKTVDMIRLAYFKSEFQNAI 116 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + ++ G + M + M + + + + + Y+VDS + DI Sbjct: 117 VLAKSLKDKGYEVFLQAMATFMYSDDEMNDMLRQINDMKPKAFYIVDSFSNLFPEDIARM 176 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLE 237 + + +L + G HAH+N+ + +N+I ++ DR ID S+ GMG GAGN P+E Sbjct: 177 AKQVLLKLDKDIDFGFHAHNNIQMAFSNAITFMDVESDRDIYIDGSIYGMGRGAGNVPIE 236 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 + + +K + +L L+ D ++P+ ++ GY + +L + Sbjct: 237 LLMDYLNKK--EKLYNLEVLLKTYQDYIKPIFEQYF--------WGYT--HPYYLTASKD 284 Query: 298 AAARY 302 + Y Sbjct: 285 MNSVY 289 >UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ Length = 379 Score = 207 bits (526), Expect = 5e-52, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 108/303 (35%), Gaps = 34/303 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + YI D TLRDG + + +IA+ LD+ VD IE Sbjct: 2 RDFYIVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAG-----------IPIMG 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 + + I + AKI L D+ + GA+ + +A ++ + Sbjct: 51 EEEKDVIREIIAMNGKAKI---LTWNRMKKMDVDASLACGAKYIHIAVPASDIHIFQKLR 107 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + Y E G + + L + + GA + D+ Sbjct: 108 KDRKWVIQQVQEVVSYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTL 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + + + + + H H++ + ANS++A + G ID S+ G+G Sbjct: 168 GILTPITTYQAIKRICDYI--DADLEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGE 225 Query: 230 GAGNAPLEVFIAAADK-LGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRETLALGYA 285 AGN LE + L H ++ +++ + + R + + +++ + Sbjct: 226 RAGNTALEEIVMTLKYLLKSNHPFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHES 285 Query: 286 GVY 288 G++ Sbjct: 286 GIH 288 >UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Mycobacterium tuberculosis KZN 4207 RepID=UPI0001B44BFA Length = 483 Score = 206 bits (525), Expect = 7e-52, Method: Composition-based stats. Identities = 79/271 (29%), Positives = 136/271 (50%), Gaps = 7/271 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + ++ A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQG-PAA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 H+D E+ AA VV++A++ +++P + I + A +R+ TE ++ + Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDY-LDFLRICVIATEFELVMPFV 125 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R A Sbjct: 126 ERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA 185 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +AA Sbjct: 186 LRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAAL 243 Query: 244 DKLGWQHGT-DLYAL--MDAADDLVRPLQDR 271 + D + + +LV P +R Sbjct: 244 QRRDLAGDYLDFLRICVIATEFELVMPFVER 274 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 81/318 (25%), Positives = 133/318 (41%), Gaps = 24/318 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + +Y+ D T G + E+ R+ +AL + V N Sbjct: 163 RIVYVVDTT---G------TFLPEDARRYVEALR--GASDVSVGF-----HGHNNLAMAV 206 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ------AGARVVRVATHCTEAD 117 + LE +A AD + + G I L A Q +R+ TE + Sbjct: 207 ANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRDLAGDYLDFLRICVIATEFE 266 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + ++ A+ G++ L+ SH+ P+ LA K G +YVVD+ G D Sbjct: 267 LVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDA 326 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 R AL+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E Sbjct: 327 RRYVEALRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIE 384 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 +AA + G DL + DAA + + +D ++ G+ G+ S + H Sbjct: 385 CLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRA 444 Query: 298 AAARYGLSAVDILVELGK 315 AA + GLS ++ + K Sbjct: 445 AAQQAGLSVSHVIRQTAK 462 >UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter lovleyi SZ RepID=B3E4J8_GEOLS Length = 531 Score = 206 bits (525), Expect = 8e-52, Method: Composition-based stats. Identities = 76/341 (22%), Positives = 139/341 (40%), Gaps = 15/341 (4%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG + L +++ I LD A VD +E+ D + S++ Sbjct: 2 KSIQILDCTLRDGGFVNDWNFGLGSMKSIISRLDKAGVDMVEIGFID--ERRSYDPNRAI 59 Query: 64 HSDLEWIEAAAD--VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 D + +A ++++ I ++ G I + + +RV + D + + Sbjct: 60 QPDTQSFQAVLQGLDIRNSLILGMVDYGTCDIDKIAPKEHSYIDGIRVIFKKKDQDAALR 119 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++Q + G + + E + + G + +VD+ G M+ D+ F Sbjct: 120 YLQQIKAKGYKIYVNPVSITGYSDEEICSLIGKINGLDPEGVSIVDTYGLMHRKDLLHYF 179 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEV 238 R L G HAH+N L ANSI E +R ID+SL GMG GAGNA E+ Sbjct: 180 RLFDKYLSNHITLGYHAHNNFQLVYANSIELCELLGERNIIIDSSLYGMGKGAGNANTEL 239 Query: 239 FIAAADKLGWQHGTDLYALMDAAD-DLVRPLQDRPVRVDRETLALG---YAGVYSSFLRH 294 ++ ++ L++A D D+++ P Y+ +L Sbjct: 240 IAMYYNE-NINSKYEVEHLLEAIDVDILKEYAKAPWGYSLSYYLAASNDCHPDYAKYLLS 298 Query: 295 CETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 +T A + S ++L L + ++I + ++ ++ Sbjct: 299 KKTLAVK---SVNELLTSLPVTHKLAFNRELIERLYVEYQD 336 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 206 bits (524), Expect = 9e-52, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 117/319 (36%), Gaps = 37/319 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L +SD TLRDG ++S+++ IAKAL DA V IE G + Sbjct: 17 LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSER----------- 65 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQH-- 122 ++E + V +I L G I A A R V + + +H Sbjct: 66 EIEAVRRICAEVPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHKL 125 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + YAR+ + T P L + + GAT I D+ Sbjct: 126 GKSKAQCLDMIGRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDT 185 Query: 169 GGAMNMSDIRDRFRALKAELKPE-TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + +R R R L A P + +H H++L L AN++AAV G D + ++ G+ Sbjct: 186 LGVLTPEAVRRRVRMLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGI 245 Query: 228 GAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRET 279 G AGNA LE + A + G D L + R PL V Sbjct: 246 GERAGNAALEETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANI 305 Query: 280 LALGYAGVYSSFLRHCETA 298 A L+H +T Sbjct: 306 FATSAGVHQDGLLKHPDTY 324 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 206 bits (524), Expect = 9e-52, Method: Composition-based stats. Identities = 54/271 (19%), Positives = 99/271 (36%), Gaps = 32/271 (11%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + +S ++ RQIA LD+ IE + Sbjct: 59 RVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDA-----------E 107 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-------- 118 E + A T D++ A +G +V ++ + Sbjct: 108 FEAVRDIASSTS----TTTCGLARVVDADIEAALDSGVEMVHTFVSTSDVQIEDSMHATR 163 Query: 119 ------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + ++ E G + M + T + L + + + G I + D+ G Sbjct: 164 DEVVERAVESVERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVA 223 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + R + A + + +H H + L AN++A +E G D+ S+ +G AG Sbjct: 224 TPTRFRAMIEKVCAH--TDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAG 281 Query: 233 NAPLEVFIAAADKLGW-QHGTDLYALMDAAD 262 NA E F+ A + L G D + + ++ Sbjct: 282 NAAYEEFVMAVESLYQTDTGIDTTRITELSN 312 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 56/306 (18%), Positives = 116/306 (37%), Gaps = 39/306 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 N + + I D TLRDG ++ + +IAK L DA V+ IE Sbjct: 25 FNRENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAG------------- 71 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-- 118 F A S+ E +++ + + + + +D+ ++ +R++ + ++ + Sbjct: 72 FPAVSNDE-MKSIKKI--NHDMENICSLARCNRNDIDKVIESDSRIIHLFIATSDIHMKY 128 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + I YAR GM + + T+ + L + ++ I Sbjct: 129 KLKKTREQVFDSIMESIDYARSYGMRIIFSPEDATRTSMDFLKQ---IVSSIKVETINFP 185 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G MN + +K+ +H H++ + AN++A + G + ++ G Sbjct: 186 DTIGIMNPISMYYFINKIKSFTSTG--ISIHCHNDFGMATANTLAGLMAGANEAQVTVNG 243 Query: 227 MGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRP---LQDRPVRVDRETLAL 282 +G AGNA LE +++ L + L + + + + + E Sbjct: 244 IGERAGNASLEEVVSSIYGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFS 303 Query: 283 GYAGVY 288 AG++ Sbjct: 304 HEAGIH 309 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 103/315 (32%), Gaps = 36/315 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ + D TLRDG + E +IA +D D IE + Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSA-----------ITSE 50 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------ 118 + E I A+I + D+ A V + ++ + Sbjct: 51 GEREGIRKITSEGLRAEICSF---ARAVREDIDAAISCDVDSVHLVVPTSDLHLEHKLRK 107 Query: 119 --------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + +YA + G+ S + + L + GA I D+ G Sbjct: 108 TREEVLEQAVDCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVG 167 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + +R L +H H++ L VANS+A + G + A++ G+G Sbjct: 168 ILTPERSYEFYRGLSE---LGAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGER 224 Query: 231 AGNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALGYA 285 AGNA LE + A L ++ L + + + R LQ V A Sbjct: 225 AGNAALEEVVVALKSLYDVDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESG 284 Query: 286 GVYSSFLRHCETAAA 300 L+ ET Sbjct: 285 IHADGVLKKAETYEP 299 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 62/261 (23%), Positives = 101/261 (38%), Gaps = 30/261 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +L I D TLRDG A + +IA+ L+ RVD+IE Sbjct: 13 QPDRLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFA-----------A 61 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 + D E I A ++++ + +L G I A + R R+ + + + Sbjct: 62 ASPGDSEAIRLIASEIRNSTLCSLARATEGDIDAAAKALEPAHR-KRLHIFLATSPIHRE 120 Query: 122 H------------IQYAREL---GMDTVGFLMMSH-MTTPENLAKQAKLMEGYGATCIYV 165 I+ + D + F T P+ L + GA + V Sbjct: 121 AKLRMSRREVLQTIERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNV 180 Query: 166 VDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G +IR F L A + H H++L L V+NS+AAV+ G +++ + Sbjct: 181 PDTVGYSEPDEIRAVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECA 240 Query: 224 LAGMGAGAGNAPLEVFIAAAD 244 + G+G AGN LE + A Sbjct: 241 INGIGERAGNCSLEEIVMALQ 261 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 204 bits (519), Expect = 4e-51, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 107/281 (38%), Gaps = 32/281 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 KK+ I D TLRDG ++ E IA+ L D VD +EV Sbjct: 8 TNKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVG-------------I 54 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 E +A ++VK +++ + D++ + G V ++ ++ + Sbjct: 55 PTMGGDEK-KAIKEIVKRNLKPSIMAWNRAVVSDIEQSIDCGVDAVAISISVSDIHIQHK 113 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + +++A++ G+ + + L + + GA D Sbjct: 114 LKTSREWVLESMVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCD 173 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G M IRD + + + + + H H + + AN++A ++ G + ++ G+ Sbjct: 174 TVGIMEPFKIRDDIKYIYDKTGFDIEM--HTHDDFGMATANAVAGIKGGASHVGVTVNGL 231 Query: 228 GAGAGNAPLEVFIAAA-DKLGWQ-HGTDLYALMDAADDLVR 266 G AGNA LE I A G+ G + + + + R Sbjct: 232 GERAGNAALEEVIMALMLVYGYNGDGINTQMFREVSQYVSR 272 >UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=Q4ZRW6_PSEU2 Length = 342 Score = 204 bits (518), Expect = 6e-51, Method: Composition-based stats. Identities = 84/309 (27%), Positives = 137/309 (44%), Gaps = 3/309 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG + ++ + + I L +A VD E+ + G +G + Sbjct: 4 VKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDV 63 Query: 66 DLEWIEAAADVVK-HAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 +IE A K ++A ++ P T DL + G ++RV + D + Sbjct: 64 GAVFIEKIAQAAKGRIELAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLS 123 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 AR+ G + TP ++ A EG GA + DS G M +D+ F L Sbjct: 124 LARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLFSRL 183 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 + L G HAH+NLSL +AN+ AA+E G + ID S+ GMG GAGN L + +A + Sbjct: 184 SSRLL--VPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYLE 241 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGL 304 + G HG DL +++ ++ R + + + LG + R+ L Sbjct: 242 RTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQL 301 Query: 305 SAVDILVEL 313 ++ +E+ Sbjct: 302 TSEYRAIEV 310 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 203 bits (517), Expect = 6e-51, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 117/308 (37%), Gaps = 37/308 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++++ D TLRDG + + +A+ L +A V IE Sbjct: 2 RQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETG-------------VP 48 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 A + E E A +VK + I DL+ + G R V + ++ ++ + Sbjct: 49 AMGEDEQ-ETIARIVKLNLPTRVTTWNRAVISDLEASLNCGVRSVAICLPSSDQQITQKL 107 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ A+ G+ V L + P+ L + E + + D+ Sbjct: 108 RQSRQWVLDQMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ + F L + L +HAH++L + AN+++A++ G ++ G+G Sbjct: 168 LGILDPIRTFNLFDRLTSSLS--IPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLG 225 Query: 229 AGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV-----RPLQDRPVRVDRETLAL 282 AGNAPLE A + +L AL+ A LV RP+ V R+ Sbjct: 226 ERAGNAPLEEVALALRQCCAADTRINL-ALLPALCRLVSWSTRRPIPFSKPVVGRDAFTH 284 Query: 283 GYAGVYSS 290 + Sbjct: 285 ASSIHVDG 292 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 203 bits (517), Expect = 6e-51, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 111/298 (37%), Gaps = 32/298 (10%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 ++ D TLRDG A + + ++A+ L + +D IEV A + Sbjct: 6 FLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVG-------------IPAMGE 52 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA---------- 116 E ++V+ + + D++ A GA + +A ++ Sbjct: 53 DE-CNTIQNIVRLKLRPIISVWSRAIKKDIEQASTLGATCIHIAFPLSDIQLQAINKTYG 111 Query: 117 ---DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 D ++ IQ A+ L + + + + + E YG + D+ G + Sbjct: 112 WVEDTFSKTIQCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILT 171 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + R +K + K HAH++ + AN++ A + G + + ++ G+G AGN Sbjct: 172 PIQTIEIIRTIKKK-KTNMNIDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGN 230 Query: 234 APLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 A LE + ++ + DL L D + RPL D + ++ Sbjct: 231 AALEEILMGLRQINGKTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIH 288 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 203 bits (517), Expect = 7e-51, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 122/305 (40%), Gaps = 36/305 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLR+G ++++ +IAKAL D V IE H Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIY-------- 54 Query: 65 SDLEWIEAAADVVKHAKIAT-LLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 E I+ + K I + ++ D++ A + + + ++ + A+H Sbjct: 55 ---EGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVNRIAIFYGVSDLHLKAKHK 111 Query: 123 -------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 I YA+ G+ T + L +K GA + + D+ Sbjct: 112 ATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTV 171 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + S ++ F AL E+ P + +HAH++L L VAN++AA+E G I A++ G+G Sbjct: 172 GILYPSKTKELFSALTREV-PNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGE 230 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYAL--MDAADDLVRPLQDRP----VRVDRETLALG 283 G PL+ AA + G ++ L + LV P + + L Sbjct: 231 RVGIVPLQQIAAAIK---YHFGIEVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLH 287 Query: 284 YAGVY 288 AGV+ Sbjct: 288 KAGVH 292 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 203 bits (516), Expect = 9e-51, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 105/349 (30%), Gaps = 51/349 (14%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG A ++ IA L D VD IE + Sbjct: 5 ITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQT--------- 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH--- 122 E + A V L I A G R+ T +DV + Sbjct: 56 --EAVTRIATEVDGPVTCALARTKEDDIDAAGEALADGTDT-RLHTFIATSDVHIEAKFD 112 Query: 123 --------------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 I+ A + + T PE L + + GAT Sbjct: 113 KLGNTMAEKREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATT 172 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPE--TQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G S+ D + L H H +L L AN++A + G ++ Sbjct: 173 INIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQV 232 Query: 221 DASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRP 272 + ++ G+G AGNA LE + A D L + + P+Q Sbjct: 233 ECTINGIGERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNK 292 Query: 273 VRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRR 317 V + L T A G A I LG+ Sbjct: 293 AIVGSNAFSHEAGIHQHGVLEERTTYEIMSATDVGQDAEQI--RLGRHS 339 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 111/314 (35%), Gaps = 35/314 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG +SLE + IA+ LDD V +E A Sbjct: 9 IIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECG-------------IPAMG 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ- 124 E + +V A L+ + D++ + Q G V ++ ++ + + + Sbjct: 56 REEQ-RSVKALVDLGLHARLITWNRALVDDIRASLQCGVNAVDISLSVSDLHIRHKLRKD 114 Query: 125 -------------YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 +A++ + + + L + +L GA D+ G Sbjct: 115 RHWVREQLKRALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGL 174 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ ++ R L + + + H H++L + AN+IA V G I+ ++ G+G A Sbjct: 175 LDPFVTFEKIRYLTQRVDLDIEV--HTHNDLGMATANAIAGVRAGARFINTTVNGLGERA 232 Query: 232 GNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAG 286 GNA LE + G + D ++ + + RP+ V A Sbjct: 233 GNAALEEVVMGLKHACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGL 292 Query: 287 VYSSFLRHCETAAA 300 L+ Sbjct: 293 HVDGVLKDPRNYEP 306 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 116/328 (35%), Gaps = 43/328 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 ++ K + + D TLRDG ++L + +IA LD+ V+ IE Sbjct: 28 VSKKSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGS--------- 78 Query: 61 FGAHSDLEWIEAAADV-VKHAKIATLLLPGIGT---IHDLK----------------NAW 100 D E+ + + A+IA D+ +W Sbjct: 79 --NPKDEEFFKEIKKYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIFGKSW 136 Query: 101 QAGARVVRVATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEG 157 A V T D+ I Y R G+ + P+ + K E Sbjct: 137 SLHATEVLKVTKQDNLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYALEVVKTAES 196 Query: 158 YGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGC 217 GA I + D+ G ++ + + ++ L + G+HAH+++ VANS+ A++ G Sbjct: 197 AGADVIALADTNGGTPPFEVYEITKKVREVL--HVKLGIHAHNDIGCAVANSLMAIKAGA 254 Query: 218 DRIDASLAGMGAGAGNAPLEVFIAAA-DKLGWQ--HGTDLYALMDAADDLVRPLQDRPVR 274 + ++ G+G GNA L I K+G+ G D + +V + P Sbjct: 255 RHVQGTINGIGERTGNADLIQIIPTLVLKMGFNVLKGRDSLRKLREVSRIVYEILGLPPN 314 Query: 275 VDRETLA----LGYAGVYSSFLRHCETA 298 + + AGV+ + A Sbjct: 315 PYQPYVGDNAFAHKAGVHVDAVMKVPRA 342 >UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LXD4_9FIRM Length = 538 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 141/332 (42%), Gaps = 15/332 (4%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + ++ + + +I + L + V+ IEV D + SSF+ G D Sbjct: 5 LLLDCTLRDGGYVNNWEFGYDRIVEIFERLVSSGVEFIEVGFLD--EKSSFDRGRTVLPD 62 Query: 67 LEWIEAAADVVKH--AKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 + + V A + ++ G +I L+ + +RV ++ + + + Sbjct: 63 TASVSRMFEGVSKGDALVLGMIDYGTCSIERLEPCEETFLDGIRVIFKESKMEAALKFYA 122 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 ++LG ++ T E LA+ AKL+ +VD+ G ++ + + L Sbjct: 123 EVKKLGYKVFAQMVSVTTYTDEKLAEYAKLVNEVMPYATSMVDTYGLLDEEHLCHIYGIL 182 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIA 241 A L P+ + G HAH+N LG AN+ + +R D +L GMG AGNAPLE+ + Sbjct: 183 DANLDPQIRVGYHAHNNFQLGYANAKHFLSLDSERGLLADGTLYGMGKSAGNAPLELLMM 242 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETL----ALGYAGVYSSFLRHCET 297 +K D+ +++A D+++ + + ++ Y L + T Sbjct: 243 FRNK-KQGARYDVNQVLEAIDNVILDIYQKQYWGYNLFFYIASSMHCHPNYVKNLMNKRT 301 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDV 329 + + DIL L + + E I + Sbjct: 302 LSVKQ---IRDILSSLEVSKSLLYDEAYIEKL 330 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 105/260 (40%), Gaps = 31/260 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK YI D TLRDG + +S ++AK +DDA + IE Sbjct: 1 MKEKK-YIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAG------------- 46 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A + E E ++++ K A + + D+ N++ ++ + + + + Sbjct: 47 IPAMGNYEK-ETISEIMSQRKNALISTWNRMSRDDINNSFDCHPDIIHITAPISYIHIYS 105 Query: 121 --------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + A++ G + + + A L+ G + Sbjct: 106 KLNKNKKWLRNTLQECVFMAKDKGYEVTVGFEDASRADITFIISMANLLADMGVKSVRFA 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + + R +K + + G+HAH++L + +ANS+ A + G ID ++ G Sbjct: 166 DTVGVLTPARTYQCIREIKENV--DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGG 223 Query: 227 MGAGAGNAPLEVFIAAADKL 246 +G AGN L FI AA + Sbjct: 224 IGERAGNCDLYQFILAAGGI 243 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 66/340 (19%), Positives = 122/340 (35%), Gaps = 49/340 (14%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N KK+ + D TLR+G ++ + QIA LD VD IE++ Sbjct: 23 NPKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEISPVVSNDHK------ 76 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 EA ++K A ++ G D+ + A+ ++ + Sbjct: 77 ---------EATKTIIKQGLKADIVSHGRALKEDIDVSLDCDAKWCAAYLGISDIHLKDK 127 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + ++YA+ G+ + PE L K K +E G I + D Sbjct: 128 LRISREDAMERAVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPD 187 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + + + + ++ + + H H+++ VAN+ +A + G D+I ++ G+ Sbjct: 188 TVGILRPIGMYNFVKKVRDSI--DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGI 245 Query: 228 GAGAGNAPLEVFIAAADKLG-------WQHGTDLYALMDAADDLVRPLQDRPVRVDRETL 280 G G PL A L DL L++ ++P +P+ Sbjct: 246 GERTGIPPLAEVAVALTYLYKSPNDFRLDMLLDLSRLIEEY-TTIKPYDSKPIVGSSAYK 304 Query: 281 ALGYAGVYSSFLRHCETAAARYG-LSAVDILVELGKRRMV 319 AG + L A Y + +G RR + Sbjct: 305 --HKAGTH---LAAILRNPAAYEPIPPR----AVGNRRRI 335 >UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LKZ4_9FIRM Length = 534 Score = 202 bits (513), Expect = 2e-50, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 127/327 (38%), Gaps = 13/327 (3%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I D TLRDG + ++ ++ I L+DA VD IE SS + Sbjct: 14 MNTTK--ILDCTLRDGGYINNWKFGGRTIKSIISNLEDAGVDIIECGFIRKEDHSSDSSV 71 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F + + I A + A ++ + GA ++R+ E + + Sbjct: 72 FSSMEQVADI--IAPKKANISYAIMIEQHNHVDKLIPENDGNGADIIRITFRRKEWEEAK 129 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I++ G + + E+L K K + Y+VD+ G M D+R Sbjct: 130 VAIKHLICKGYKVCVQPVGTVTYDDESLLKLIKDVNQIKPYAFYLVDTLGVMYRHDMRRF 189 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLE 237 F + L E G H+H+NL + AN+ + R +D S GMG G GN E Sbjct: 190 FYLIDNNLSKEICLGFHSHNNLQMSFANAQEMMRLAKQRSIIVDTSCYGMGRGVGNLATE 249 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQ-DRPVRVDRETL---ALGYAGVYSSFLR 293 +F +K ++ L +++ D + P+ ++ D + Y+++L Sbjct: 250 LFADYVNKT-IEYRYALTPILNIVDKYLMPVYAEQRWGYDLPYFLAATVKCHPNYAAYLM 308 Query: 294 HCETAAARYGLSAVDILVELGKRRMVG 320 +T + + L+ + +R Sbjct: 309 KKDTIGIE-KIERILSLIPVEERNEYN 334 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 201 bits (511), Expect = 3e-50, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 105/276 (38%), Gaps = 31/276 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I+D TLRDG A ++ E +IAK L +A D +E+ A Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIG-------------IPAMG 48 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH--- 122 + E E ++ L+ T DL+ + G + V ++ + V+A+ Sbjct: 49 EAER-EDIRAILSLGLPLRLMSWNRATQSDLEASLACGMKAVDLSIPVSTKMVAAKFRGK 107 Query: 123 -----------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A++ G+ + + L + L GA + D+ G Sbjct: 108 YAKVLSNLEETLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGI 167 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + R+L+ MH H++ + VANSIA +E G ++ ++ G+G A Sbjct: 168 LTPLQTYRAIRSLRRHCT--LPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERA 225 Query: 232 GNAPLE-VFIAAADKLGWQHGTDLYALMDAADDLVR 266 GNA E V ++ + G D L + + Sbjct: 226 GNAGFEQVLLSLIGQFGQNRTLDSTILKALVQKVAK 261 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 201 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 69/372 (18%), Positives = 127/372 (34%), Gaps = 63/372 (16%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 I D TLRDG + ++ +IA LD+ V++IE ++ + Sbjct: 52 EIFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGF-----------PITSNGE 100 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD--------- 117 E ++ + +A I L D+ + + + Sbjct: 101 FEAVKKIKQLDLNATICGLSRCSN---KDIDAVIDCDLDRIHLFIATSPLHREYKLKKSK 157 Query: 118 -----VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 ++ I YA+E G+ + T + L + K I + D+ G + Sbjct: 158 EQILNKISESIIYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGIL 217 Query: 173 NMSDIRDRFRALKAELKPETQT---------------------GMHAHHNLSLGVANSIA 211 + + + LK+ L+ +H H++ L VANS++ Sbjct: 218 TPKKMENLIKDLKSGLETNKAINNSSTLTNQINIKSNMQMPVLSVHCHNDFGLAVANSLS 277 Query: 212 AVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL-GWQ---HGTDLYALMDAADDLV-- 265 A E+G +I ++ G+G AGN L F+++ L G + L D + + Sbjct: 278 AFEQGVSQIHCTVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHY 337 Query: 266 --RPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQE 323 P+ V R A + + T +S D+ KRR+V G+ Sbjct: 338 TNIPIAPNKPLVGRNAFAHESGIHTHGVIANALTYEP---ISPFDV---GNKRRLVLGKH 391 Query: 324 DMIVDVALDLRN 335 + L L+ Sbjct: 392 AGAHSIKLKLQE 403 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 201 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 108/277 (38%), Gaps = 33/277 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG +S E +A LD ++ IE + Sbjct: 23 IEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGF-----------PVVSAD 71 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E ++ A+ +++I L G D+ A + +V + ++ + Sbjct: 72 EKEIVKEIANQGFNSRICCLSRAVKG---DVDAALECDVDIVSIFIAMSDMHLKYKYHRS 128 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLME-GYGATCIYVVDSGG 170 + + I+YA + G+ + T E L + K +E Y + + D+ G Sbjct: 129 LEDMLGCAKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVG 188 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +N + + + T +H H +L + AN++AA E G ++ ++ +G Sbjct: 189 ILNPTTTNYLVSEIFKSV--NTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGER 246 Query: 231 AGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVR 266 AGNA LE + A + G + D L ++ + Sbjct: 247 AGNASLEEVLVALRVQYGIE-RYDTTKLNSLSEMVSE 282 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 201 bits (510), Expect = 5e-50, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 111/311 (35%), Gaps = 36/311 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + R +S + R+IA LDD IE Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDA----------- 58 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E + A A T+ D+ A +G +V V ++ + Sbjct: 59 EFEAVSDIAA----ATNTTVCGLARVVEGDIDAAIDSGVEMVHVFVSTSDVQLEDSMHAT 114 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++ ++ G++ + M + T P+ L + + + G I + D+ G Sbjct: 115 RQEAKQRAVAAVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGV 174 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + +A+ + + +H H + + AN++ E G ++ S+ G+G A Sbjct: 175 AMPTSFGKTVKAVVNA--TDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERA 232 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 GNA E + A + G G D + A + P+ R A Sbjct: 233 GNAAYEEVVMAVESVYGVDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGI 292 Query: 287 VYSSFLRHCET 297 + + + +T Sbjct: 293 HAAGVIENADT 303 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 122/294 (41%), Gaps = 33/294 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K L I+D TLRDG A ++L IAKALD+A VD IE A Sbjct: 7 KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAG-------------IPA 53 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 E IEA +V+ ++ A ++ I D+ A + GA+ V ++ + ++A+ Sbjct: 54 MGASE-IEAIRQIVQQSQTARVIPWCRMKISDVDKALETGAKTVHLSISSSPFQMAAKFP 112 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 I YA++ G+D + L ++E GA I D+ Sbjct: 113 DLSAADILGLCQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADT 172 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ + L + + H H +L L ANS+AA++ G ++ G+G Sbjct: 173 LGILDPFATYEIISQLHQISPLDIE--FHGHDDLGLATANSLAAIKAGAKGASVTVLGLG 230 Query: 229 AGAGNAPLE-VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLA 281 AGNAPLE V IAA+ G + L + A V R + D+ + Sbjct: 231 ERAGNAPLEQVVIAASHIAGKETRILPEKLYNLAQ-YVAQAAGRTIPPDKAIVG 283 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 117/320 (36%), Gaps = 38/320 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ D T+RDG I ++++ ++A+AL+ V +IE + Sbjct: 10 QITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGF-----------PAASK 58 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D + + + VV AK+ L I + A Q A+ + + V + Sbjct: 59 KDFDAVVEISKVVHTAKVVGLARLVRQDIDAVVAATQQ-AKHPMIHVFIATSPVHRTYKL 117 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 I+Y + + + + + T PE LA+ + GAT I + D+ Sbjct: 118 HMSPSEIIEKVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPDT 177 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + F L+ ++ + H H++L + AN++A + G I ++ G Sbjct: 178 VGYATPYEYGELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTING 237 Query: 227 MGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRE 278 +G AGN + AA Q L +D + P+ + R Sbjct: 238 IGERAGNVDIIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGRN 297 Query: 279 TLALGYAGVYSSFLRHCETA 298 A +L++ ET Sbjct: 298 AFAHESGIHQDGYLKNPETY 317 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 122/342 (35%), Gaps = 39/342 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M + I DVTLRDG ++ + + IA LD ++ IE Sbjct: 1 MKPWHIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEK---- 56 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 E + + + AKI L D+ A A ++ + ++ + Sbjct: 57 -------EMVRNISRLGLSAKICGLSRACR---EDVDAALDAEVDMIGLFIAPSDLHLKY 106 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +H + YA + G+ + T P+ L + + AT + Sbjct: 107 KHKKPRDVVVANALEQLDYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYA 166 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + ++ + L K MHAH++L AN++ A E G ++ ++ G Sbjct: 167 DTTGCLTPLEVATVMKDLVP--KTPIPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNG 224 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLAL 282 +G AGNA LE + + G DL + ++ + + + V A Sbjct: 225 LGERAGNARLEEVLVSLVLKGGITRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAH 284 Query: 283 GYAGVYSSFLRHCETA----AARYGLSAVDIL-VELGKRRMV 319 ++ L + ET GL IL GKR +V Sbjct: 285 ESGIHIAAILENPETYEFIPPELLGLERRFILGKHTGKRALV 326 >UniRef50_C4Z863 HMGL family protein n=4 Tax=Bacteria RepID=C4Z863_EUBR3 Length = 323 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 129/309 (41%), Gaps = 18/309 (5%) Query: 1 MNGK-KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFN 58 M + + + D T+RDG ++ + + + +A A +D +E + + Sbjct: 8 MTARPDIRVLDATIRDGGLVNNFMFTDDFINALYRANVKAGIDYMEFGYKASKELFDVNK 67 Query: 59 YGFGAHSDLEWIEAAA-DVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEA 116 +G D I D KI+ + G D+ + +VRVAT+ + Sbjct: 68 FGKWKFCDEAAIREIVGDNNSDMKISVMADVGRCDYKKDILPREDSVIDMVRVATYVHQM 127 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + + I+ A+ G + +M T +L + ++ A IY+VDS GA+ Sbjct: 128 PAAIEMIEDAKSKGYEVTCNIMAISNTQESDLDQALDMVAKSSADGIYIVDSYGALYPEQ 187 Query: 177 IRDRFRALKAELKPETQ-TGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 IR + + GMHAH+N L AN+I A +G +DA++ GMG GAGN Sbjct: 188 IRRIAEKYTEIAEANGKFVGMHAHNNQQLAFANTIEAAAQGVSLLDATMMGMGRGAGNCA 247 Query: 236 LEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVY--SSFLR 293 +E+ ++ + +++ ++ ++ + PL++ GY Y + L Sbjct: 248 MELLLSFLKNPKY----NVFPVLKFIEEHMLPLKESG-------AVWGYDIPYLLTGRLN 296 Query: 294 HCETAAARY 302 +AA Y Sbjct: 297 QHPSAAIDY 305 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 122/307 (39%), Gaps = 21/307 (6%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+YI D TLRDG +SLE+ +IA+ LDD + IE + + Sbjct: 2 AEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQKA 61 Query: 63 AHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC 113 + + + A V + ++ +L+ + +W T Sbjct: 62 KKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTLE 121 Query: 114 TEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 ++ + ++Y + + + + + PE + + GA + + D+ G Sbjct: 122 ENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTNG 181 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +I + + +K K + G+HAH++ VANS+ AV G ++ ++ G+G Sbjct: 182 GTLPHEIYEITKKVKERFK-DANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGER 240 Query: 231 AGNAPLEVFIAAAD-KLGWQHGT--DLYALMDAADDLVRPLQDRPVRVDRETLA----LG 283 GNA L I KLG+ +L L + A + V + + P+ + + Sbjct: 241 TGNANLCSIIPNLQLKLGFDVIPQENLKKLTELA-NFVAEIINMPLPRNMPYVGESAFAH 299 Query: 284 YAGVYSS 290 GV++S Sbjct: 300 KGGVHAS 306 >UniRef50_Q4HR83 4-hydroxy-2-ketovalerate aldolase, putative n=2 Tax=Campylobacter RepID=Q4HR83_CAMUP Length = 330 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 132/326 (40%), Gaps = 13/326 (3%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I D TLRDG H ++ E +RQI L +A +D IEV LQ F Sbjct: 2 NIQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGL---LQNHQCGVDFSIF 58 Query: 65 SDLEWIEAAADVV--KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + +++++ + K++K + +L + L + + +R+A + + ++ Sbjct: 59 NSIDFVDQCLSSIEKKNSKFSLMLRTDRVDFNKLAKSPK--VDFIRIALYQEHLNDIKRY 116 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + A+ELG + + + +P + K +E I +VD+ G+ +++ + Sbjct: 117 GEKAKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLVDTFGSFTLNEFEKVLK 176 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVF 239 L P G+H H NL+L ++ + A + +R ID+SL+GMG GN E+F Sbjct: 177 IFDKNLSPNITLGIHLHQNLNLALSLAAKATKLIINRDLIIDSSLSGMGRVPGNLQSELF 236 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 ++ + H ++ L+ + + + + ++ E Sbjct: 237 ANYLNQ-NFNHQYNIEKLLSLTALIEEFKILNRWGYNPIYMYSASLNIDRTYPEFFEKMG 295 Query: 300 --ARYGLSAVDILVELGKRRMVGGQE 323 L+ I E G +E Sbjct: 296 FCIENNLNLQKICKEKGIGSKFNEEE 321 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 104/281 (37%), Gaps = 35/281 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K + D TLRDG +Y+ E +IA+ LD A ++SI+ + + Sbjct: 16 KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLS------ 69 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 I D+ +I ++ D+ A G V + ++ + A+ Sbjct: 70 -----IRKICDLGLKMRIMSMC---RVIREDIDFASSCGVEGVILFIPGSDIHLKAKFGE 121 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 I+YA++ G+ + S T L + E GA + Sbjct: 122 DIPAVRKNIVQKAMDAIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTT 181 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + + + L LK G+H H+++ L AN+IA + G ++ G Sbjct: 182 DTIGYLTPERTYNFIKKLVRNLK--LPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNG 239 Query: 227 MGAGAGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVR 266 MG AGNA LE I L D L + + + + Sbjct: 240 MGERAGNASLEEVIMILKVLYNQDLKYDTKILGELSKTVEK 280 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 197 bits (501), Expect = 4e-49, Method: Composition-based stats. Identities = 78/339 (23%), Positives = 125/339 (36%), Gaps = 41/339 (12%) Query: 1 MNG-KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M + L + D TLRDG +SL + IA+ALD A V IEV Sbjct: 1 MTPDRTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVG------------ 48 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV- 118 A E + VV AT ++ +HDL A + G + V A + A + Sbjct: 49 -IAAMGWAE-VAEIRAVVAEIAHATPVVWCRLRMHDLDMAQKTGVKRVHFAVPTSTAQLE 106 Query: 119 -------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 +A + A + G+ + T P+ L + A++ GA + Sbjct: 107 GKLRVDRDWILRETAALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRI 166 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G ++ L A + MHAH++ + AN+I A G + ++ Sbjct: 167 ADTLGLLDPLGAFRLVAELSARIS--LPIEMHAHNDFGMATANTIMAAHAGATHLSVTVN 224 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ-----DRPVRVDRETL 280 G+G AGNA E AA + G G DL AL + + + + +P+ D Sbjct: 225 GLGERAGNAACEEVGAALEAGGIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLF 284 Query: 281 ALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMV 319 A + L+ +T G+ R + Sbjct: 285 AHESGIHVDAILKRADTYE-----DPRCAPARFGRERQI 318 >UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034 Length = 497 Score = 197 bits (501), Expect = 5e-49, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 112/322 (34%), Gaps = 43/322 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + +IA LD+ V+SIE + Sbjct: 2 KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSA-----------ITSE 50 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------ 118 + E I+A +A+I + I D+ + V + ++ + Sbjct: 51 GEREAIKAITSQGLNAEIVSFSRTLI---KDVDYCLECDVDAVNIVVPTSDLHLQYKLKK 107 Query: 119 --------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + +YA++ G+ S T + L K K GA I D+ G Sbjct: 108 TQDEMLEDAVKVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLG 167 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + ++ H H++ L VAN+++A++ G R A++ G+G Sbjct: 168 ILTPLKSFNFYKQF---TDLGVPVSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGER 224 Query: 231 AGNAPLEVFIAAA--------DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 AGNA LE + + ++ ++ + + + + R L V Sbjct: 225 AGNAALEEVVVSLYTLYKDESNERKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGEN 284 Query: 279 TLALGYAGVYSSFLRHCETAAA 300 A +++ T Sbjct: 285 AFAHESGIHADGVIKNSATYEP 306 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 197 bits (500), Expect = 5e-49, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 108/295 (36%), Gaps = 33/295 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG +S+++ IA LD+ VD IE + Sbjct: 31 KVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGM-----------PAVSP 79 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC----------- 113 D I + + +KI T D+ A Q GA V + Sbjct: 80 QDATAITEISKLGLKSKIYTF---ARAMKADIDMALQCGADGVIIEVPIGYPKLKTQFGW 136 Query: 114 ---TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAK-LMEGYGATCIYVVDSG 169 SA I YA+E G+ V F + +L K +M+ I +VD+ Sbjct: 137 TWEDVVKKSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIGLVDTM 196 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G I+ R L E +H H++ +GVA +AAV G + + G+G Sbjct: 197 GCATPEAIKYMVRWLTK--MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGLGE 254 Query: 230 GAGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALG 283 GNA LE + L G+ L + + L+ + + ++ L G Sbjct: 255 RTGNAALEELMMGLHLLYGYDTQYKLGKIPELGA-LIAERSNISIARNKPVLGHG 308 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 197 bits (500), Expect = 6e-49, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 104/283 (36%), Gaps = 35/283 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+ I D TLRDG +S E+ +IA+ L + V+ IE + Sbjct: 28 PQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSKD-------- 79 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVA------------ 110 D + IE A KI D+ A GA + + Sbjct: 80 ---DAQAIEEIAKRNLGPKIMVFC---RAMREDVDRAVDCGADGIVLEAPSGYPKLKYQF 133 Query: 111 ----THCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLM-EGYGATCIYV 165 T + + I YA+E G+ F + L + + + V Sbjct: 134 ASKWTEESLTEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVTTQAKPDSVTV 193 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 VD+ G++ + +R R ++ + +H H++ LG A + AAVEEG + + + Sbjct: 194 VDTTGSITPTAMRFLVRQVRETIA--LPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCIN 251 Query: 226 GMGAGAGNAPLEVFIAAADKL-GWQHG-TDLYALMDAADDLVR 266 G+G GN LE L G + + L + + ++ R Sbjct: 252 GLGERTGNTALEEIALGLKLLYGIELPKFNFQKLSELSQEVQR 294 >UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4 Length = 380 Score = 197 bits (500), Expect = 7e-49, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 107/306 (34%), Gaps = 35/306 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MNGK + ++D TLRDG A +S QI K L + IE + Sbjct: 1 MNGK-ILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCK------- 52 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS- 119 +++E + +I G T DL+ + V ++ ++ +S Sbjct: 53 ----TEMEAFHKILSLGLKVRIVA---WGRMTNEDLQAVKSSRVSTVNLSIPLSDIQIST 105 Query: 120 -------------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +++ ARE+G++ S L + ++ + GA Sbjct: 106 KLRTNRKQVLEKIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYA 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ LK H H + + ANSIAA G I A+L G Sbjct: 166 DTVGILDPLCTYQTLSRLKK--WTSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCG 223 Query: 227 MGAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRETLAL 282 +G AGN LE + G DL L L + + E + L Sbjct: 224 LGERAGNGALEEIAFFLALRENVDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFL 283 Query: 283 GYAGVY 288 +G++ Sbjct: 284 HESGIH 289 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 108/276 (39%), Gaps = 31/276 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 I D TLRDG + +S+E I ALD A+V IE A Sbjct: 7 FEIIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAG-------------IPAMG 53 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS------ 119 E E ++ + L+ + DLK + G + V V+ ++ + Sbjct: 54 KQE-CEDLKLMLNLPIKSNLIAWNRANLEDLKASIDCGFKFVHVSLPVSDLHIEHKLQKS 112 Query: 120 --------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++Y + + + + PE L + A + YGA I D+ G Sbjct: 113 RTWVLDQLKKCMEYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGC 172 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ + + + P +HAH++ L VAN++AA + G ++ G+G A Sbjct: 173 LDHFTTYRKIKEIADHSPP--PVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERA 230 Query: 232 GNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVR 266 GNA +E + + + G +L AL A+ + + Sbjct: 231 GNASMEETAFSLKRFYNYDCGIELEALPFLAEMVSK 266 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 119/301 (39%), Gaps = 30/301 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLR+G +S++ +IA+AL DA V IE H + + Sbjct: 2 IGLLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSE-----------T 50 Query: 66 DLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD------- 117 L+ I++ ++ I +T++ D+ A ++ + ++ Sbjct: 51 VLKSIKSIMELKSSGIIRSTIVAHSRAVRSDIDVAASLNIDMIAIFYGISDLHLKYKTLK 110 Query: 118 -------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + I YAR G++ + T L A+ GA I + D+ G Sbjct: 111 TREDAIRIIVDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVG 170 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +N F+ + ++K + +HAH++L + VANSIAA G I +++ G+G Sbjct: 171 ILNPDTSYKLFKMIIKDVK-NVEFDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGER 229 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP---LQDRPVRVDRETLALGYAGV 287 +G P ++ A + DL L ++ + + + V + +GV Sbjct: 230 SGITPTQIIGPALKYHYNEAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGV 289 Query: 288 Y 288 + Sbjct: 290 H 290 >UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI Length = 418 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 119/338 (35%), Gaps = 42/338 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ +SD TLRDG E R+IA AL+ A + S++ + Sbjct: 28 RIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGF-----------PASSQ 76 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQH- 122 D + I A V+K + L G + A A R V+ + + ++ Sbjct: 77 QDFDAIRLMAQVIKRPVMTALCRTVEGDVDAADEALAGLAPHKRGVSLFIGTSPLHREYK 136 Query: 123 ---------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 ++YA + + T + L + + GAT I D Sbjct: 137 LRKSRTEVLSIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPD 196 Query: 168 SGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + R + + + +H H++L L VANS+A + G + ++ Sbjct: 197 TVGVLTPERAYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVN 256 Query: 226 GMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGNA LE A ++ G + +L + + P+ R Sbjct: 257 GIGERAGNAALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGR 316 Query: 278 ETLALGYAGVYSSFLRHCETA----AARYGLSAVDILV 311 A L+H +T G A+++++ Sbjct: 317 TIFATEAGIHQDGLLKHPDTYLPYRPEVVGGPAIELVL 354 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 114/310 (36%), Gaps = 34/310 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+ D TLRDG A + ++A L+ A +++IE + Sbjct: 5 KRKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSK--------- 55 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNA---------------WQAGARVV 107 D + + ++K + AT + I A Sbjct: 56 --EDFISTQKISKILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKK 113 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 R + + + + YARE G+ V + + + + + + GA I + Sbjct: 114 RKMSRQDGIEEIKKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQSGANQIILA 173 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G +DI D + K + + +H H++L L V NS A+ G D I ++ G Sbjct: 174 DTTGYAMPNDIYDLVKLSKRCISKSIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGG 233 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGT-------DLYALMDAADDLVRPLQDRPVRVDRET 279 +G AGN +E +A G +LY + + + + ++R + + + Sbjct: 234 IGERAGNTSIEQVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKY 293 Query: 280 LALGYAGVYS 289 + AG++ Sbjct: 294 VFSTAAGIHQ 303 >UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B7ANX1_9BACE Length = 538 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 71/348 (20%), Positives = 131/348 (37%), Gaps = 19/348 (5%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG I ++S + +R I++ L D+ +D +EV + F Sbjct: 2 KNISILDCTLRDGGRVINCEFSDDEIRDISRRLSDSNIDIVEVGFLRDSKKVHFEGNSTF 61 Query: 64 HSDLEWIEA-AADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVAT----HCTEADV 118 +D+ I + + G+ L +RV + + D Sbjct: 62 FTDVNQIAPYLDKSSGNCMYVAFIDYGMFDFDTLGQCDGTSVDGIRVGFTKKDYYSSRDD 121 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + + + G + S + + + L+ +VD+ GAM D++ Sbjct: 122 IIRCLNIVKARGYKLFVQGVNSLSYSDKEMLDLVDLVNEVHPYSFGIVDTYGAMYEDDLQ 181 Query: 179 DRFRALKAELKPETQTGMHAHHNLSL--GVANSIAAVEEGCDR--IDASLAGMGAGAGNA 234 + + + + H+H+N L +A SI + + IDA+L GMG AGN Sbjct: 182 RIYALINNNMHKDICIDFHSHNNYQLSFSLAQSIIRLSDSVRHIIIDATLNGMGKVAGNL 241 Query: 235 PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRH 294 E+ + + D ++D DD + P +++ ++ G+Y S + Sbjct: 242 NTELIVDYMVR-KLNCNYDFEQILDIIDDYIYPYKEKDFW--GYSIPALIGGMYQSHPNN 298 Query: 295 CETAAARYGLSAVDI-----LVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L DI ++E KR D I + L+ NK Sbjct: 299 VLYLTNKFRLQTKDIKNLLSMIEPAKRTRY--DYDNIERIYLEYSGNK 344 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 106/319 (33%), Gaps = 37/319 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L ISD TLRDG +S+ + IA+AL+ A VD IE G G Sbjct: 10 LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAG----------- 58 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW-QAGARVVRVATHCTEADVSAQH-- 122 ++E + A I L + A A A V + + +H Sbjct: 59 EIEAVRQVAAATARPLIMALCRAVDADVDAAWQALGDAPAERRGVGVFLATSPLHRRHKL 118 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + YAR+ T P L + GAT I D+ Sbjct: 119 GKTKAQCLAMIASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDT 178 Query: 169 GGAMNMSDIRDRFRAL-KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + R R L + + H H++L L AN++AA+ G D + ++ G+ Sbjct: 179 VGVLTPETARRRIAMLVRLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGI 238 Query: 228 GAGAGNAPLEVFIAAADKLGWQH----GTDLYALMDAADDLVRP----LQDRPVRVDRET 279 G AGNA LE + A Q+ D L + + L Sbjct: 239 GERAGNAALEETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANV 298 Query: 280 LALGYAGVYSSFLRHCETA 298 A L+H +T Sbjct: 299 FATAAGVHQDGLLKHPDTY 317 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 114/310 (36%), Gaps = 40/310 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G Y+ E +IA ALD+ VD IE+ H + Sbjct: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSE-------------- 47 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA----------- 116 + + + LL I D+ + G V + +EA Sbjct: 48 DVFRGMKLIAEQGLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLD 107 Query: 117 ---DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + ++ I+YA++ G+ + T NL + +L + I V D+ G+ + Sbjct: 108 HALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTH 167 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + + + +H H++L L +AN+I +E G +DA++ G+G AG Sbjct: 168 PLRFYTLVKKI---VNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGI 224 Query: 234 APLEVFIAAADKLGWQHGTDLYA--LMDAADDLVRPLQDRPVRVDRETLA----LGYAGV 287 L I + +G Y L+ +LV + + + + AG+ Sbjct: 225 VDLAQIITVL---YYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGL 281 Query: 288 YSSFLRHCET 297 + S + Sbjct: 282 HVSAVLKDPR 291 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 73/372 (19%), Positives = 137/372 (36%), Gaps = 36/372 (9%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +++YI D TLRDG +S+E+ + I L++ VD +E + + + Sbjct: 104 MARERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFK 163 Query: 61 FGAHSDLEWI------EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 + +++ A V +++LL + + +W R+ T+ Sbjct: 164 RRQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAVCFVAKSWDYHVRLALGCTNEE 223 Query: 115 EADVSAQHIQYARELGMD---TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + AR G + + PE AK GA + + D+ G Sbjct: 224 NLESITASVTAARMAGREALVDCEHFFDGYKANPEYALACAKAAYSAGARWVVLCDTNGG 283 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ A+KA + P G+HAH++ VA S+AA++ G + +L G+G Sbjct: 284 TQPLEVAAIVEAVKA-VVPGESLGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGERC 342 Query: 232 GNAPLEVFIAAADKLGW-----QHGTDLYALMDAA-------DDLVRPLQDRPVRVDRET 279 GNA L I + + G +L D L RP ++ Sbjct: 343 GNANLVSLIPTLVLKPYWAERFELGIKPASLKSITRISRAFDDILNRPATEQAPYTGTSA 402 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAV----------DILVELGKRRMVGGQEDM 325 A S+ ++ +T G S + + EL +R + ++D+ Sbjct: 403 FATKAGIHASALMKEPQTYEHIPPESVGNSRRVMVSDQGGKSNFIAELERRGIRVAKDDV 462 Query: 326 IVDVALDLRNNK 337 +D + L + Sbjct: 463 RLDTLIALVKER 474 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 98/258 (37%), Gaps = 30/258 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + SD TLRDG QIAKAL+ A V S++ + + Sbjct: 30 VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGF-----------PASSQA 78 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQH-- 122 D++ I++ V+K + L G + A R V+ C + + Q Sbjct: 79 DIDAIQSMVGVIKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKL 138 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 IQYA E + T + L + + GAT I D+ Sbjct: 139 EKSKSEVLKLIVDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDT 198 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + +D ++ E+ +H H++L L VAN++A ++ G + + ++ G Sbjct: 199 VGILTPWKAQDFICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNG 258 Query: 227 MGAGAGNAPLEVFIAAAD 244 +G AGNA LE A Sbjct: 259 IGERAGNAALEEVAMALH 276 >UniRef50_C4Z4L3 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z4L3_EUBE2 Length = 326 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 114/269 (42%), Gaps = 9/269 (3%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNYGFGAH 64 + + D TLRDG +++ E V+ + +A A VD +E + +G Sbjct: 15 IKVMDCTLRDGGLVNNFEFTDEFVKDLYEANVAAGVDYMEFGYKADKDIFDEKEFGKWKF 74 Query: 65 SDLEWIEAAADVVKHA-KIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEADVSAQH 122 E I A KI+ + G + D+ ++ +VRVAT+ + + Sbjct: 75 CKEEDIRAIVGENDTPLKISVMADVGRTNMKRDIPPKSESVVDMVRVATYINTIPAAIEM 134 Query: 123 IQYARELGMDTVGFLM-MSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 Y ++G + +M +S E L A IY+VDS G++ +R Sbjct: 135 ANYCSDMGYEVTVNIMAISTAGENELDLALELLASQSKAQYIYLVDSYGSLYPEQVRRLA 194 Query: 182 -RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 + +K K G+HAH+N L AN+I A G +DA+++GMG GAGN E+ + Sbjct: 195 DKYIKIAEKYGKSVGIHAHNNQQLAFANTIEACSIGVSLLDATVSGMGRGAGNCYSELLL 254 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQ 269 + ++ ++ + + PL+ Sbjct: 255 GFLRNPKF----NIVPVLKFIEKHMVPLK 279 >UniRef50_Q24S97 Putative uncharacterized protein n=1 Tax=Desulfitobacterium hafniense Y51 RepID=Q24S97_DESHY Length = 547 Score = 194 bits (492), Expect = 5e-48, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 119/290 (41%), Gaps = 10/290 (3%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ + D T+RDG + + +E V + KA A V+ E+ + Sbjct: 5 KQFIMLDCTVRDGGYINNWAFPIEIVASMYKASSTAGVEIFEIGFLS----EDTSLPLWR 60 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 S ++ + A+I+ +L + L + G V+R+A + + + Sbjct: 61 QSPAWAVKQVTQEYQGAQISAILEANTVGMK-LGIPEETGIDVLRIALNKDKVVECIPKM 119 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGGAMNMSDIRDRFR 182 + G LM T + KL++ G I + DS G++ + Sbjct: 120 ADYKAQGYTVFVQLMGITGYTDIEILNICKLLDECGYIDYINIGDSYGSLLPERTTEIIS 179 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K + + G+HAH+N+ LG+AN +AAV G + +D SL GMG G GN PLE+ ++ Sbjct: 180 MMKRNTR--LKVGLHAHNNMQLGMANVLAAVAAGANIVDGSLYGMGRGGGNVPLELLLSY 237 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRVDRETLALGYAGVYSSF 291 K + D+ ++D D + + Q+ L G + + Sbjct: 238 YGK-KFPDCYDVLPVLDFIDRYMIRIRQEFEWGYTLNNLLSGVYECHPYY 286 >UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY Length = 508 Score = 193 bits (491), Expect = 7e-48, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 100/308 (32%), Gaps = 36/308 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDG A + + IA++L+ A V IE G Sbjct: 13 RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAGER------- 65 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 + I D+ A++ + G D+ A V + ++ + Sbjct: 66 ----QAISRVTDLELDARVTSFC---RGMESDIDLALDCDVDGVHIVVPASDRHIEDKVG 118 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +A+ + YA++ + + L + GA I D+ Sbjct: 119 TSHEDNLEKTAELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTV 178 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + L H H +L LGVAN++AAV G D + ++ G+G Sbjct: 179 GHTGPERTAEAVGRL----ADVGPVSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGE 234 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGN LE A + +L L D A + R L + Sbjct: 235 RAGNVALEEVAIALSHVYDVETLELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESG 294 Query: 286 GVYSSFLR 293 L+ Sbjct: 295 IHTDGTLK 302 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 193 bits (491), Expect = 7e-48, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 120/347 (34%), Gaps = 26/347 (7%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+ I D TLRDG S+E+ +IA LD VD IE + Sbjct: 2 AEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLRA 61 Query: 63 AHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC 113 A + A + + G+ +W T Sbjct: 62 REVIWRQARLVAFGRTRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLHVTAALGTTLA 121 Query: 114 TEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + + + G++ + P+ + K GA+ I + D+ G Sbjct: 122 ENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYALETLKAAAKAGASWIVLCDTNG 181 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +I + ++ E+ + G+HAH++ L VAN++AAV GC ++ ++ G G Sbjct: 182 GCLPWEIEEAVARVRQEI--QVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGFGER 239 Query: 231 AGNAPLEVFIAAAD-KLGWQ-HGTDLYALMDAADDLVRPLQDRPVRVDRETLAL----GY 284 GNA L + + K+G+Q A + V + + ++ + Sbjct: 240 CGNADLCSVMPNLELKMGYQCLPPGQLAFLTEVSRYVSEIANVVPAGNQPFVGYSAFAHK 299 Query: 285 AGVYSSFLRHCETA-----AARYGLSAVDILV-ELGKRRMVGGQEDM 325 G++ S + + G ++ + G + E+M Sbjct: 300 GGIHVSAVLKAPDTYEHIRPQQVGNERRVLMSDQAGASNLRCKAEEM 346 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 191 bits (485), Expect = 3e-47, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 102/272 (37%), Gaps = 30/272 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + ++I D TLRDG A ++ E + IA L + V+ +E+ + Sbjct: 12 KRPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYP------------A 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE-----AD 117 S+ + + ++ + L D+ A + + V ++ +E D Sbjct: 60 ISSEEQAV--ITEIARMQLPLRLTSWARAKWEDIDAAIRCKTQGVHISFPLSELYLQLMD 117 Query: 118 VSAQHIQ--------YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + ++ A++ + T P+ L + + GA I + D+ Sbjct: 118 KPYEWVEEQLHLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTV 177 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + +K + HAH++L + AN+ +A+E GCD + S+ G+G Sbjct: 178 GIATPLHLMQLISRIKKAVP--ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGE 235 Query: 230 GAGNAPLEVFIAAADKLG-WQHGTDLYALMDA 260 AGNA LE A G + L + Sbjct: 236 RAGNAALEELAIALKLSGRYHSSIKTERLQEL 267 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 191 bits (485), Expect = 3e-47, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 102/294 (34%), Gaps = 44/294 (14%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 NGK + I D TLRDG ++L+ IA LDD V+ IE Sbjct: 7 NGKTIEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGS---------- 56 Query: 62 GAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIHD-------------------LKNAWQ 101 DLE+ + ++++KIA I + Sbjct: 57 -NPKDLEFFKLIKKHELRNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSS 115 Query: 102 AGARVVRVATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGY 158 + + ++ + + RE G+ T + PE + K E Sbjct: 116 FHVEKILNCSLEDNLEMIYDSLIFLRESGLQTYFDAEHFFDGYNINPEYAIQTVKTAEEA 175 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 I + D+ G M I + +K E + G H H++ VAN+++AV G Sbjct: 176 KVNTIVLCDTNGGMLPHQIERVVKKIKKN--SEVKIGFHGHNDTGCAVANTVSAVVAGAT 233 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAAD-KLGWQHG-------TDLYALMDAADDL 264 I ++ G+G GNA L I + KL + + L D ++ + Sbjct: 234 HIQGTINGLGERTGNADLCQVIPNLEMKLKKKTRNIQKKQIINFGKLRDISNYI 287 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 189 bits (481), Expect = 9e-47, Method: Composition-based stats. Identities = 70/350 (20%), Positives = 117/350 (33%), Gaps = 36/350 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDGM ++++ ++A+ LDD V IE + A Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAA 61 Query: 64 HSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 D + A V K I LL G + + W V T + Sbjct: 62 KIDFKNARLTAFGSTRRAGLAVEKDDNIRLLLECGAPAVALVGKTWDLHITEVMSNTLES 121 Query: 115 EADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 ++ + Y + G + E K GA + + D+ G Sbjct: 122 NLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQAGADAVILCDTNGG 181 Query: 172 MNMSDIRDRFRALKAELKPE---------TQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ + L Q G+H H++ +L VANSIAA+ G + Sbjct: 182 ALPHDVEAITAEVCTTLADRFPGPDGGSTVQVGIHTHNDSNLAVANSIAAIRAGARIVQG 241 Query: 223 SLAGMGAGAGNAPLEVFIAAA-DKLGWQ--HGTDLYALMDAADDLVR-----PLQDRPVR 274 ++ G G GNA L I K+ + +L L + + P+ RP Sbjct: 242 TINGYGERCGNADLTSIIPILAAKMEYDCITPENLKKLRKVSRFVSETANMTPVNSRP-- 299 Query: 275 VDRETLALGYAGVYSSFLRHCETA-----AARYGLSAVDILVELGKRRMV 319 ++ G++ S + A G ++ +L R V Sbjct: 300 FVGKSAFSHKGGLHVSAIMKNPRAYEHMDPELVGNKRRVLISDLSGRSNV 349 >UniRef50_B3QVI9 Pyruvate carboxyltransferase n=5 Tax=Bacteroidetes/Chlorobi group RepID=B3QVI9_CHLT3 Length = 510 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 116/267 (43%), Gaps = 13/267 (4%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + + E V++ + + VD +E+ + L + F + Sbjct: 2 KVLDCTLRDGGYYTNWDFDGELVQKYFSSFEKLPVDYLEIGY-RSLPEKEYRGRFYYLPN 60 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV---RVATHCTEADVSAQHI 123 I+ + K+ +A +L +L A V+ R+A D + Sbjct: 61 F-VIDEITQLSKNKLLAIMLNEKSVQPKNLDKILDGLAPVISLIRLAVDPKNFDSALLLG 119 Query: 124 QYARELGMDTVGFLM-MSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + R+ G D LM MS E+ + + G A+ + +VDS G M ++ Sbjct: 120 EAIRKRGFDVAFNLMYMSKYANDESFLGKLSSLNGL-ASYVNMVDSYGGMVPEQVKILIH 178 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K+ + G H H+N+ L ANS+AA++ GC+ +D ++ GMG GAGN E+ + Sbjct: 179 NVKSYCRE--AIGFHPHNNMELAFANSLAAIDAGCEIVDTTVMGMGRGAGNLRTELLLTY 236 Query: 243 A---DKLGWQHGTDLYALMDAADDLVR 266 +KL L +L++A L R Sbjct: 237 MASKNKLELDFNV-LASLIEAWMPLYR 262 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 112/316 (35%), Gaps = 36/316 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++++ D TLRDG +S E +A ALD V+ IE A Sbjct: 2 PQVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAG-------------IPA 48 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 E +A V+ A +L D++ + GA ++++ ++ + Sbjct: 49 MGVDEQ-KAVRAVLGAGLRARVLAWNRAHPSDIEASLACGATCLQISFPVSDIHLQHKLG 107 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + A G + + P L AK E GA + D+ Sbjct: 108 RTRSWLLARLEEVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G ++ RD L +L HAH++ + AN++AAV+ G +D ++ G+G Sbjct: 168 GVLDPFRSRDAVSDLTHKL--NIPLEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGE 225 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYS 289 AGNA L G + + + + + + VR + Y Sbjct: 226 RAGNASLSAVA-----RGLRQFYGMEVVREETELAMLEGWVNSVRKRAAFFSRDYGLTLG 280 Query: 290 SFLRHCETAAA-RYGL 304 +F R RY L Sbjct: 281 AFNRALRNGEQTRYRL 296 >UniRef50_A7VV06 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV06_9CLOT Length = 520 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 66/339 (19%), Positives = 129/339 (38%), Gaps = 15/339 (4%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG + ++ + I + L D+ D +EV L+ S++ + Sbjct: 3 IRLLDCTLRDGGYINDWKFGYRTAKSIIQKLVDSNADYVEVGF---LRNCSYDKNATLFN 59 Query: 66 DLEWIEAAADVV-KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 ++ ++ K+ K + L I L+ VRV H + D + ++ Sbjct: 60 NIAELKKILPREQKNTKFTVMALHNKYDITKLEP-NDGTVEAVRVTFHDYDIDEGLEFVK 118 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 E G + + + + + + +VD+ G+M SD+ + L Sbjct: 119 KVMEKGYKCFCNPINIMGYSDQEILNLIQKINQIKPYAFSIVDTFGSMIKSDLLRIYSLL 178 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD------RIDASLAGMGAGAGNAPLEV 238 + L G+H H NLSL + + + G ID SL GMG GN LE+ Sbjct: 179 EHNLDKSIVIGLHLHENLSLSYSLAQEFI--GMRNVNRDCVIDGSLMGMGRVPGNLCLEL 236 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQ-DRPVRVDRETLALGYAGVYSSFLRHCET 297 + +K ++ +++DA DD + ++ + P E ++ ++ + Sbjct: 237 IMDYMNKYD-SVKYNVDSVLDAIDDHILAIRKESPWGYTTEYSLSAKYNLHRNYAEYLIG 295 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 IL + K + E I + L+ ++ Sbjct: 296 KGQLKAKDINHILSNISKDKKTAFDEAYIERLYLEYQDK 334 >UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CL40_9FIRM Length = 528 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 121/319 (37%), Gaps = 25/319 (7%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + D TLRDG + ++ + + Q + L + VD +E+ F Sbjct: 4 IQTLDCTLRDGGYLNDWEFGYKMICQTVRQLIASNVDYVELGFLRNEDYQPDRTVFRHVK 63 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D K+ + + L I L++ + +RV H + + ++ + Sbjct: 64 D--AYHILPKDCKNTRFTLMSLHNKYDISQLEDYDGGPIQRIRVTFHDYDVEEGLEYCRK 121 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 E G + + + L + + + T +VD+ G+M +D+ + + Sbjct: 122 VMEKGYEVACNPINIMGYSDGELLEILRKVNEIHPTVFSIVDTFGSMKRNDLIRLYSLCE 181 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCD----RIDASLAGMGAGAGNAPLEVFIA 241 L + G+H H NLSL + + + ID SL GMG GN +E+ + Sbjct: 182 NNLSKDITIGLHLHENLSLSYSLAQEFLNIKSYSRNCVIDGSLLGMGRVPGNLCIELILD 241 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAAR 301 + + ++ ++DA DD + P++ GY+ YS +A+ Sbjct: 242 YLNN-NYAKTYNIDPILDAIDDYIVPIKRLE--------PWGYSTAYS--------LSAK 284 Query: 302 YGL--SAVDILVELGKRRM 318 Y L + + L+ GK + Sbjct: 285 YNLHRNYAEFLLNKGKLKA 303 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 58/315 (18%), Positives = 111/315 (35%), Gaps = 34/315 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG A + E ++A L++ VD IE + Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKF--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLP------------GIGTIHDLKNA---WQAGARVVR 108 D E + + V + IAT G H ++ + R Sbjct: 53 --DYEATKLISKEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKR 110 Query: 109 VATHCTEADVSAQHIQYARELG-MDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + +++A++ + + + + + + GA I + D Sbjct: 111 NISRSQAIEEVINTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILAD 170 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G S+ + + ++++ H H++L L AN++A +E G D + +L G+ Sbjct: 171 TTGYATPSEFKKLIQFIRSKTGDGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGI 230 Query: 228 GAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALG 283 G AGNA LE+ + + L L +L + + + R G Sbjct: 231 GERAGNASLEMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIG---LDIPRNQPVFG 287 Query: 284 YAGVYSSFLRHCETA 298 ++ H + Sbjct: 288 TYAFSTAAGIHQQGV 302 >UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI Length = 974 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 98/250 (39%), Gaps = 23/250 (9%) Query: 24 YSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEWIEAAADVVKHA--- 80 + + IA+ L VD IE + DL+ ++ A V +A Sbjct: 1 MTSKEKLDIARQLAKLGVDIIEAGF-----------PAASKDDLDAVKIIAKEVGNAVDE 49 Query: 81 --KIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGF-L 137 + + +D+ AW+A + +++ + ++YAR LG D V F Sbjct: 50 NGHVPVICGLARCNRNDISTAWEA---YKLKKSEKEVIEIAREMVKYARSLGCDDVEFSP 106 Query: 138 MMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTG 195 + + E L K + GAT + + D+ G ++ +K+ Sbjct: 107 EDAGRSEREFLYKILGEVIKAGATTLNIPDTVGYTVPNEFGQLIADIKSNTPGIENVIIS 166 Query: 196 MHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF-IAAADKLGWQHGTDL 254 H ++L L AN+IA G +++ ++ G+G AGNA LE + G T L Sbjct: 167 THCQNDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLEEVCLIYRLAPGLCTDTQL 226 Query: 255 YALMDAADDL 264 +++ + +L Sbjct: 227 NGVINLSMNL 236 >UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO Length = 277 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 117/285 (41%), Gaps = 29/285 (10%) Query: 1 MN--GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 MN +++ I D T+RDG + S ++A+ L++A+VD IEV++ Sbjct: 1 MNNLSEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVSY---------- 50 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT---- 114 + D + I A + +K++ + L + I ++ +R R+ + Sbjct: 51 -PAKSQQDFDEIVAVSREIKNSIVCALSNLSVQEIERAATGLKSASRG-RIHLYSNVNLA 108 Query: 115 ---------EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + Q + AR D + + + L + ++ GA I + Sbjct: 109 KKEPLKRQEALSMIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINI 168 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 DS G + ++ + + ++ +H H + + NS+ A+E G +I+ S Sbjct: 169 PDSLGVLLPAEFAQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECS 228 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 L G+GA GNA L+ I D+ + + + A++LV+ + Sbjct: 229 LNGLGARKGNANLKSVIKEIDQNPTYKTSVILEKIPPAEELVKQI 273 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 119/316 (37%), Gaps = 47/316 (14%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG A +S+++ + +ALD +D IE + Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGS-----------NP 51 Query: 65 SDLEWIEAAADV-VKHAKIAT-------------------LLLPGIGTIHDLKNAWQAGA 104 DLE+ E V +KH+K+ LL G + +W Sbjct: 52 KDLEFFELVKSVELKHSKLVAFGSTRRKDVAPEEDQNLISLLQAGTEYVSIFGKSWDFHV 111 Query: 105 RVVRVATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGAT 161 + T ++ + + + G + + PE + K + GA Sbjct: 112 TDIIKTTLENNLEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYALEALKAAKDGGAE 171 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + + D+ G +I + +K +L + + G+HAH+++ GVANSIAAVE G ++ Sbjct: 172 ILTLCDTNGGCFPEEISRITKEVKEKLG-DIKIGIHAHNDMGFGVANSIAAVEAGALQVQ 230 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYA-----LMDAADDLVRPLQDRPVRVD 276 + G G GNA L IA + +L L+ + ++ + + + Sbjct: 231 GTFLGYGERCGNANLSTIIANLQ---LKKDYELVPREKLGLLTSTARIIAEISNITIEDS 287 Query: 277 RETLA----LGYAGVY 288 + G++ Sbjct: 288 MPYIGKNAFAHKGGMH 303 >UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK Length = 285 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 54/232 (23%), Positives = 95/232 (40%), Gaps = 34/232 (14%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 KL I D TLRDG + + + +IA+ L+ RVD IE G Sbjct: 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNG---------- 53 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEA------ 116 D E ++ A+ +K + + +L D+ A +A GA R+ T + Sbjct: 54 -DFEAVQLIANSIKDSTVCSL---SRANDRDIARAAEALKGANSARIHTFIATSALHMEK 109 Query: 117 ----------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + Q +++AR L D + + P+ L + + + GA+ I V Sbjct: 110 KLRMTPEQVLEQAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTINVP 169 Query: 167 DSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEG 216 D+ G + + L+ + + +H H++L + VANS+A V+ G Sbjct: 170 DTVGYAVPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIG 221 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 125/354 (35%), Gaps = 40/354 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I+D TLRDG + + +IA+AL +A V +E A Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGT-------------PALG 64 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 + E + A + + ++ ++ ++ + G V ++ ++ Sbjct: 65 EEECVRLAI-LRRQLPDTVMMSWCRMNSAEIHDSARVGMDWVDISVPASDLLREQKLHRP 123 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 +Q A LGM + + E L A++ G + D+ G Sbjct: 124 WPAVIASLKPLVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGI 183 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ R AL+ + HAH++L + AN++AAV G ++ ++ G+G A Sbjct: 184 LDPFSTFTRISALRQHWHGGLEI--HAHNDLGMATANTLAAVRAGATHVNTTVLGLGERA 241 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSS 290 GNA LE + D+ L G D L A LV R + V + G + S Sbjct: 242 GNAALESVTLSLDRCLHLDCGIDFTEL-PALCRLVAAAAGRTIDVQHPLVG-GQVFTHES 299 Query: 291 FLRH--CETAAARY-GLSA----VDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L Y G+ + + LGK + + L + Sbjct: 300 GLHVAALLRDPRSYQGIDPSLVGREFNLVLGKHSGRQAVSGICARLGYILSETQ 353 >UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU Length = 265 Score = 187 bits (474), Expect = 6e-46, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 110/273 (40%), Gaps = 34/273 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + I D TLRDG + +++E +IAK LD+ + IE Sbjct: 2 KRNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIECG-------------IP 48 Query: 63 AHS--DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS- 119 A + E I+A K+A I+T I D+K + ++ ++ ++ + Sbjct: 49 AMGCMEQEIIKAIKANTKNALIST---WNRLNIDDIKASMNCKPHIIHISVPVSDLQIYE 105 Query: 120 -------------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + I Y +E G D L + + + + + L+E G I Sbjct: 106 NLNKDKKWIEENLIKCIYYTKEQGYDVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYS 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G +++ ++ ++ + +HAH++ + + S+ AV+ G + +D +L G Sbjct: 166 DTVGILSLLKTKNVVNEIRRN--SNLKVEIHAHNDFGMALGISVEAVKNGAEFVDCTLDG 223 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMD 259 +G GN L+ F+ + + + ++ Sbjct: 224 IGERTGNCSLQEFLKISRNFECDYEMNNDNVIK 256 >UniRef50_A2U042 HMGL-like protein n=1 Tax=Polaribacter sp. MED152 RepID=A2U042_9FLAO Length = 516 Score = 187 bits (474), Expect = 6e-46, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 16/294 (5%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGD----GLQGSS 56 MN K I D TLRDG + + E V+ +++ +D +EV + G G Sbjct: 1 MN-KTFKILDCTLRDGGYYTNWDFDRELVKTYCSSMESLPIDYVEVGYRSIPLEGYLGEY 59 Query: 57 FNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA 116 F +L+ + + +V I + +L Q ++R+A Sbjct: 60 FYCPDFVMKELKQMMPSKKLV---IILNEKDIRASHVPELLKPCQGYISMIRIAVDPANF 116 Query: 117 DVSAQHIQYARELGMDTVGFLM-MSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMS 175 + + + + + +G + +M MS + + ++ Y+VDS G + Sbjct: 117 ERAIELAKAIKVMGFEVAFNVMYMSEWKEDNSFLDLLEDLDSI-IDYFYMVDSFGGVFQD 175 Query: 176 DIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 D++D R +K+ K Q G H H+NL + +AN+I A+ EGC+ +DA++ GMG GAGN Sbjct: 176 DVKDIIRLVKS--KTNVQLGFHGHNNLEMALANTITAINEGCEIVDATITGMGRGAGNLR 233 Query: 236 LEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYS 289 E+ I + G+ G L L ++ L ++G YS Sbjct: 234 TELLITFLNSKGYD-GIPFGDLSQTV-TLFEEMKKEYGWGTN--LPYMFSGAYS 283 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 103/277 (37%), Gaps = 28/277 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG +S + QIA+ L++ VD+IE+ + Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYA-----------K 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-------VVRVATHCTEAD- 117 D++ I A + V+K + + L I+ + + + +V + + D Sbjct: 56 DIDEIIAVSQVIKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDK 115 Query: 118 -----VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + I A+ + L + + GA I + DS G Sbjct: 116 NSILSTLKKQISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVA 175 Query: 173 NMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 D + + L + +H H++L V NS+ +E G +I+ ++ G+GA Sbjct: 176 LPEDFYNLLQKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGAR 235 Query: 231 AGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR 266 GNA L + + + + L+ +L++ Sbjct: 236 KGNANLTKVVNLIQSHHSYYTTIN-HNLIPKISELIK 271 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 186 bits (473), Expect = 8e-46, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 40/307 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 I D TLR+G ++ + IAK LD VD IE F +H Sbjct: 38 FEIIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIE-----------LVNPFASHQ 86 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA--------- 116 E A A++ AKI + D++ + G V + +EA Sbjct: 87 AREDCRAIANLGLKAKIVAHT---RCHMDDVRACVETGIDGVSMYMATSEALRRHSHGKS 143 Query: 117 -----DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 D + + I++ ++ GM+ + + L ++ G + + D+ G Sbjct: 144 VQAVIDSAREVIEFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGI 203 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + A+++ +KPET H H++ +AN++ A++ G I+ + G+G Sbjct: 204 ATPFQVAETVAAVRSIIKPETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERN 263 Query: 232 GNAPLEVFIA---AADKLGWQHGTDLYALMD------AADDLVRPLQDRPVRVDRETLAL 282 G PL F+A D+ ++ DL L AA + P + + + Sbjct: 264 GITPLGGFLARMYTLDRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNY---ITGSSAFT 320 Query: 283 GYAGVYS 289 AGV+S Sbjct: 321 HKAGVHS 327 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 114/304 (37%), Gaps = 20/304 (6%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGS--------S 56 K++ D TLRDG +S+++ IA+ LDD +D IE Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGE 61 Query: 57 FNYGFGAHSDLEWIEAAADVVKHAK-IATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 N + A + V+ + + L+ G + +W R + Sbjct: 62 LNLKHSKLTAFGSTRFAKNPVEEDRNVKALVEAGTPVVSIFGKSWDLHVRRALGISLEEN 121 Query: 116 ADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + + Y G + V + P+ + + GA+ + + D+ G Sbjct: 122 LVLISDTVGYIHGHGREVVYDAEHFFDGYTADPDYALRTLEAAHKAGASVLCLCDTNGGT 181 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + ++ + G+H H++ L VAN+IAAVE G + + G G G Sbjct: 182 VTGRLVEIVAEVRKRF--DGIIGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGERCG 239 Query: 233 NAPLEVFIAAAD-KLGWQH-GTDLYALMDAADDLVRPLQDRPVRVDRETLA----LGYAG 286 NA L IA + KLG G + A + + + L + P+R D+ + G Sbjct: 240 NANLASVIANLELKLGHTTVGPEKLAGLSSTCRFIAELANLPLRNDQPFVGKSAFAHKGG 299 Query: 287 VYSS 290 V+ S Sbjct: 300 VHVS 303 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 111/321 (34%), Gaps = 42/321 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG A + ++A+ L+ A VD +E + S Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFA-----------ASSSS 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHC---------- 113 D E I + V+ + +L HD++ A +A AR R+ Sbjct: 58 DFEAIRRISCCVRGCVVCSL---ARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEK 114 Query: 114 ------TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 D +A ++ AR D S P L AK GAT + V D Sbjct: 115 LRMHPLDVVDRAAAMVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTD 174 Query: 168 SGGAMNMSDIRDRFRALKAE--LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + D L + +H H+++ L +AN++AA+ + + ++ Sbjct: 175 TVGHGIPEQLSDVAGMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVT 234 Query: 226 GMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDR 277 G+G AGNA LE + AA G D + A R L V Sbjct: 235 GIGERAGNAALEEVVVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGC 294 Query: 278 ETLALGYAGVYSSFLRHCETA 298 A +++ T Sbjct: 295 HAFAHASGIHQDGVIKNRRTY 315 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 60/349 (17%), Positives = 121/349 (34%), Gaps = 41/349 (11%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 I D TLRDG +S + I K LD V IE ++ Sbjct: 2 IIDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAG-----------IPVMGLAE 50 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA---------- 116 E+ ++ A+I + I D++ + AGA + ++ ++ Sbjct: 51 SRMFESIMELGLDARI---IAWNRALIGDVQASIAAGANSIEISLPMSDVQINTKLNKTR 107 Query: 117 ----DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 D + + + + + LA+ + +E +GA D+ G + Sbjct: 108 GWILDQVKSVLDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGIL 167 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + ++ + + H H++ + AN++AAV G ++ ++ G+G AG Sbjct: 168 DPFKTYELTAKIREITSMDIEI--HTHNDFGMATANALAAVRAGATHVNTTVIGLGERAG 225 Query: 233 NAPLEVFIAA-ADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 NAPLE I A G D + ++ + R L + + Sbjct: 226 NAPLEEIIMASRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIH 285 Query: 288 YSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L++ + A ++ ++ R +V G + + + L Sbjct: 286 TDGVLKNPKNYEA---FDPAELNMQ---RNLVFGNQSGLAVLKYILEQE 328 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 183 bits (465), Expect = 7e-45, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 102/254 (40%), Gaps = 30/254 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N K + D TLR+G + E +IA+ALDD VD IE+ + S + Sbjct: 33 NVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD--- 89 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------ 115 EA + AKI T + + D + A + G V V ++ Sbjct: 90 --------CEAICKLGLKAKILTHI---RCHMDDARVAVETGVDGVDVVIGTSKFLRQYS 138 Query: 116 --------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 A + + I++ + G++ S + +L K ++ G + + D Sbjct: 139 HGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIAD 198 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G N + + R LK+ + + + H H++ +AN+ A+E G ID S+ G+ Sbjct: 199 TVGCANPRQVYELIRTLKSVVSCDIE--CHFHNDTGCAIANAYTALEGGARLIDVSVLGI 256 Query: 228 GAGAGNAPLEVFIA 241 G G PL +A Sbjct: 257 GERNGITPLGGLMA 270 >UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS Length = 535 Score = 183 bits (464), Expect = 9e-45, Method: Composition-based stats. Identities = 68/263 (25%), Positives = 101/263 (38%), Gaps = 35/263 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + SL + QIA+ LD D IE + Sbjct: 2 KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPNPSN----------P 51 Query: 65 SDLEWIEAAADV-VKHAKIATLL---LPGIGTIHD----------------LKNAWQAGA 104 +D E+ + DV +KHAKIA PGI +D +W Sbjct: 52 TDEEFFKLIKDVKLKHAKIAAFGSTRRPGILPENDPLLQALIKSEAPVKTIFGKSWDLHV 111 Query: 105 RVVRVATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGAT 161 V T D+ + Y +E + + + PE + K E A Sbjct: 112 TDVIRTTLEENLDMIESSVAYLKEHSEEVIYDAEHFFDGYKANPEYALETLKAAELGHAD 171 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 CI + D+ G +I + + ++ + T G+H H++ L VANSI AV+ GC + Sbjct: 172 CIVLCDTNGGTMPWEIEEIVKKVQTRIS--TPLGIHVHNDSGLAVANSIYAVKAGCVMVQ 229 Query: 222 ASLAGMGAGAGNAPLEVFIAAAD 244 + G G GNA L A Sbjct: 230 GVVNGYGERCGNANLTTIAADLK 252 >UniRef50_Q12KS9 Pyruvate carboxyltransferase n=2 Tax=Gammaproteobacteria RepID=Q12KS9_SHEDO Length = 539 Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 122/304 (40%), Gaps = 19/304 (6%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K I D TLRDG + + E V A+ +++D +E+ + F+ F Sbjct: 2 KNFSILDCTLRDGGYYNNWDFCPEVVSAYLDAMAKSKIDYVELGLRN-FPKKGFDGPFAY 60 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGI----------GTIHDLKNAWQAGARVVRVATHC 113 + E + ++ +A ++ ++VRVA H Sbjct: 61 TT--ESFLKGLGLPSGPTYGVMVDAKTVLDAPMTIEQAIDKLFVDASKSPIKLVRVAAHF 118 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGA-TCIYVVDSGGAM 172 E + S ++ + G LM + E +A +AK+ + + +Y DS G M Sbjct: 119 HEVEHSGPIVKALKAKGYIVGYNLMQAGGKPNEVIAAKAKVASQWNSLDSLYFADSLGNM 178 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + +++ +AL+ E + G+H H+N+ + N++ A E G + +D ++ GMG GAG Sbjct: 179 DATEVTRIVKALRTEWSGD--IGIHTHNNMGKALDNTLTAKELGVNWLDVTVTGMGRGAG 236 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALG-YAGVYSSF 291 NA E +A + + ++ + +Q LG V+ ++ Sbjct: 237 NAQTESLLAVLSNVTNYYL--PSSVYELVIRHFEQMQKVSGWGSSLLYFLGAQNDVHPTY 294 Query: 292 LRHC 295 +++ Sbjct: 295 IQNL 298 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 119/314 (37%), Gaps = 35/314 (11%) Query: 6 LYISDVTLRDGMH-AIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I D TLR+G A +S E +IAK L +D IEV H Sbjct: 2 VQIVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVS------------ 49 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE--------- 115 +E + ++V + + ++ + D++ + A+ V + E Sbjct: 50 --IEQKQIVREIVA-SNLCPVIAHARANLADIEAVKETSAQWVGIFLGINEETRLTRARW 106 Query: 116 -----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + + YA+ LG+ + T L + GA CI D+ G Sbjct: 107 TISKIFNCIKESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVG 166 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 M +++ + LK++ +H H++ L +AN++AA + G +RI +S+ G+G Sbjct: 167 IMEPNEVTETIEKLKSDFST-VPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGER 225 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSS 290 G + G + ++ V PV ++ ++ G A ++++ Sbjct: 226 CGITDTLGLLVNLYYKGLR-SLPSGEIIQRTSKYVAAFSRYPVNFNQP-ISGGNAFIHTA 283 Query: 291 FLRH--CETAAARY 302 L + + Y Sbjct: 284 HLHQKAVKRDPSSY 297 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 116/315 (36%), Gaps = 35/315 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + +++D TLRDG A ++ +IA+AL A V IE Sbjct: 30 ARTAFLNDTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGT-------------P 76 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS--- 119 A D E IE +V + + DL A AG V ++ ++ + Sbjct: 77 AMGDEE-IETLRSIVSLKLPLRVAAWCRMSEEDLFAAVSAGVTYVNLSIPTSDRQLKGKL 135 Query: 120 -----------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + A +LG + P+ L K A++ + GA + + D+ Sbjct: 136 NRDRDWALGALRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADT 195 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ R + + + HAH +L L AN++AAV G ++AG+G Sbjct: 196 LGVLDPFSAYALVRRVANA--TDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLG 253 Query: 229 AGAGNAPLEVFIAAADKLGW-QHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 AGNA LE A + + G D +AL A ++ RP+ V + Sbjct: 254 ERAGNAALEEVAIALRQTARSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHE 313 Query: 284 YAGVYSSFLRHCETA 298 S L+ T Sbjct: 314 SGIHVSGLLKDRGTY 328 >UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD Length = 531 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 103/308 (33%), Gaps = 38/308 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + + D TLRDG A + +IA+ LD + ++ IE +G Sbjct: 22 TVQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEG---------- 71 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------ 118 + E I + A + + G D++ A G V + ++ + Sbjct: 72 -ERETIRQVTGLDLDATVTSF---ARGVKSDIELAVDCGVDGVTIVVPASDQHIETKVGS 127 Query: 119 --------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 +A+ ++YA++ + E L + + GA D+ G Sbjct: 128 TRSEVVTTTAELVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVG 187 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 N + L A L P H H +L L + N ++ G D + ++ G+G Sbjct: 188 HANPETTYEYVSRL-AALGP---VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGER 243 Query: 231 AGNAPLEVF-IAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGN LE IA A + T L L A + + PL + Sbjct: 244 AGNVALEEVAIALAHGYDIETAT-LDQLYSLAQTVSQATNIPLPPNKAVIGENAFTHESG 302 Query: 286 GVYSSFLR 293 L+ Sbjct: 303 IHTDGTLK 310 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 108/307 (35%), Gaps = 34/307 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M K+ I+D TLR+G A ++S+ + IA ALD VD IE+ H Sbjct: 1 MQRKRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRT- 59 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE----- 115 EA A + AKI D++ + GA V + + Sbjct: 60 ----------EAVAKLGLGAKIIAH---ARAHRTDIEAVSRTGATWVGIFLGVNDITTKA 106 Query: 116 ----------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + A ++ A++ G++ + T L GA I Sbjct: 107 RVIGRSTTELIRMVADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICY 166 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G +++ + +K+E P+ + +H H + L +ANS+AA++ G D I S+ Sbjct: 167 ADTLGIAEPAEVARKVTLMKSEF-PDAEVEVHLHDDRGLAMANSLAAIDAGVDSISVSVN 225 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLA 281 +G G L + G + D+ L + + P V Sbjct: 226 ALGERCGITDLATLLVNLGFRGERALPDISELRALSRLVAMSSNTPFDALRPIVGDNAFK 285 Query: 282 LGYAGVY 288 G Sbjct: 286 HGSKLHQ 292 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 98/286 (34%), Gaps = 28/286 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 ++I D TLRDG A + +A LD A VD +EV + Sbjct: 7 VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQ--------- 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA----- 120 + I+A A + + D+ + V ++ ++ + A Sbjct: 58 --DEIKAIAGLNPDCLLTA---WCRALKDDIDQSLLCNVTGVHISFPVSDIHLEAMGKTR 112 Query: 121 --------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 I YA + + L + GA + + D+ G Sbjct: 113 SWVLNQLSVLIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLA 172 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 S + + L H H++L + AN+IAA+E G + ++ G+G AG Sbjct: 173 RPSQVENMVHVLSKAAGK-MALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAG 231 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRE 278 NAPLE + AA L + + V +RP+ D+ Sbjct: 232 NAPLEQVVVAAGTLDSRSTCVDARRLSEICRYVAEAVNRPIPADQP 277 >UniRef50_D0FNJ3 Conserved uncharacterized protein n=2 Tax=Erwinia pyrifoliae RepID=D0FNJ3_ERWPY Length = 333 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 112/315 (35%), Gaps = 28/315 (8%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M + + D T RDG + + + V A+ + VD +E + + Sbjct: 1 MTNSNVILLDCTFRDGGYYTNWNFDEDLVNIYYSAIIETDVDIMEAGYISVDASDCGRFK 60 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDL-----KNAWQAGARVVRVATHCTE 115 S ++ A I + + + HD+ K + ++RVAT + Sbjct: 61 VENISGFNFLSVIPGKSWAAMIDSKSILCLENWHDIVIHILKKPARPVIDIIRVATKFNQ 120 Query: 116 ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGGAMNM 174 D Q G LM + E + + + +Y+ DS G+M Sbjct: 121 LDNIDQLCNIISASGYRVALNLMQIDLACEEEVTAVFEKISSIKSIETVYLADSFGSMPP 180 Query: 175 SDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNA 234 + + LK G HAH+N+ + + NS+ A++ G + ID + AGMG GAGNA Sbjct: 181 QRVAELITRLKEITSAN--IGFHAHNNMGMALINSMTAIQAGANWIDTTFAGMGRGAGNA 238 Query: 235 PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRH 294 E K G + A D L++ D+ + T G +Y Sbjct: 239 ATEELSELIKKPGTET--------PAVDVLLKRHMDKL----KTTYNWGGGVLY------ 280 Query: 295 CETAAARYGLSAVDI 309 A + + + Sbjct: 281 --RRAGKKKIHPTYV 293 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 93/264 (35%), Gaps = 31/264 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + D TLRDG A ++ IA ALD V IE + Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGM-----------GVT 70 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ- 124 + + + A+I + D++ A G + ++ + ++ + Sbjct: 71 ERDVLREILATDPKAEI---VGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLERD 127 Query: 125 --YAR-----------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 +AR + GM + + A + G T + D+ G Sbjct: 128 RAWARRRVRDCVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGL 187 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ DR L + +HAH + L AN+IAAV+ G + ++ G+G A Sbjct: 188 LDPVSAYDRLGRLVRAVPG--PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERA 245 Query: 232 GNAPLEVFIAAADKLGWQHGTDLY 255 GNAP+E A L + DL Sbjct: 246 GNAPIEEVAMALRHL-LKLPIDLD 268 >UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT Length = 415 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 109/306 (35%), Gaps = 42/306 (13%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN +++ I DVTLRDG ++ + IA+ LD V IEV Sbjct: 32 MNLPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSG------ 85 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT----- 114 D + + + AK L D+K A + GA + T Sbjct: 86 -----EDQRVFKRLSKMNLKAKKIAL---ARIMDEDVKLAAECGADGLFYETSINPYFVK 137 Query: 115 ---------EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQA--KLMEGYGATCI 163 D + + A+ELG+ + K +L++ I Sbjct: 138 YVLGLDSKEFIDRIIKGAKLAKELGLFVEFCGWDTFRINNLEWIKTVYTELLKNVEVDQI 197 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G + + R +K E P +H H++ L A ++ A+ G + ++ S Sbjct: 198 GISDTFGQAHPFTVNFLVRKMK-EWFPSIPLSIHVHNDYGLATATALMAIASGAEAVETS 256 Query: 224 LAGMGAGAGNAPLEVFIAAADK-LGWQHGTDLYALM-------DAADDLVRPLQDRPVRV 275 +G GNA E IA + LG + D L + + V P ++P+ Sbjct: 257 FNCLGERTGNASTEEVIAGIEMILGIKTNVDCQELYRVSKMIQEVSKMHVAP--NKPIVG 314 Query: 276 DRETLA 281 DR + Sbjct: 315 DRIFDS 320 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 102/278 (36%), Gaps = 36/278 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M Y+ D TLRDG A +SL + IA L + IEV Sbjct: 1 MYPDNRYLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVG------------- 47 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A + E + + + +L G DL+ A ++GA + + + Sbjct: 48 IPAMGECER-QHIRAISQLDLDCRILTWGRAVREDLRAASKSGADGFHFSLPASPLHLRI 106 Query: 121 Q----------HIQYARELGMDTVGFLM----MSHMTTPENLAKQAKLMEGYGATCIYVV 166 + A+E DT + + + L + GA+ + + Sbjct: 107 WKKNERWVLRTMSELAKEA-ADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIA 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G +N D D F + HAH++L + VAN+++A G ++ G Sbjct: 166 DTTGRLNPIDTLDLFCDITKNAS--IDLEFHAHNDLGMAVANTVSAFIGGATCASVTVNG 223 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 +G AGNA LE A +H TD+ MDA+ Sbjct: 224 LGERAGNAALEEVSMAL-----KHSTDIDIPMDASHYY 256 >UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO Length = 373 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 109/299 (36%), Gaps = 34/299 (11%) Query: 10 DVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEW 69 D TLRDG +S E I AL +A V SIE+ A E Sbjct: 9 DTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIG-------------IPAMGGEE- 54 Query: 70 IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----------- 118 ++ VV A L++ G D++ + G V V + + Sbjct: 55 LDFIKSVVDRQDEARLVVWHRGVREDVERSLDLGFTSVHVGLPTSAGHLKASVRKDRTWL 114 Query: 119 ---SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMS 175 + ++ A++ G T L + A ++ GA + + D+ G + Sbjct: 115 LATARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPE 174 Query: 176 DIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 +R A+ + + HAH++ L AN++A ++ G ++ +G AG A Sbjct: 175 AYGERVAAVLSA--ADIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMAD 232 Query: 236 LEVFIAAADKLG-WQHGTDLYALMDAADDLVRPLQDRPV---RVDRETLALGYAGVYSS 290 L + A KL G DL L + + + + + + + +G++++ Sbjct: 233 LAQVVVALKKLYDRDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIHAN 291 >UniRef50_B1T1D8 Pyruvate carboxyltransferase n=1 Tax=Burkholderia ambifaria MEX-5 RepID=B1T1D8_9BURK Length = 304 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 69/244 (28%), Positives = 109/244 (44%), Gaps = 8/244 (3%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAH--GDGLQGSSFNYGFG 62 + + D TLRDG + H +S + I L + VD IEV + L+ + Sbjct: 13 TVTLLDCTLRDGGYINDHDFSAPQIDAILTRLIASGVDVIEVGYFRRRNLERHAATIAHC 72 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 H+ L + A V + ++ PG DL VVR D +A Sbjct: 73 PHAFLASLARQAPV----RYGVMVPPGDVEAADLDELADLPVSVVRFTCTDRNLDKAAAL 128 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + A+ LG+ T G + +P LA+ + + G +Y DS GA++ +D+ D Sbjct: 129 GERAKRLGLTTCGNITRVSECSPAQLAEVTRTLAAAGFDTLYAADSNGALHPTDVTDIVG 188 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 ++ Q G HAH +L L VAN++AA+ G +D ++ G+G G GNA +EV +A Sbjct: 189 EMRRHFTG--QLGFHAHDSLHLAVANALAAMSAGASWVDGTIGGVGKGGGNAAIEVLLAE 246 Query: 243 ADKL 246 K Sbjct: 247 VSKT 250 >UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1 Length = 429 Score = 178 bits (451), Expect = 3e-43, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 103/277 (37%), Gaps = 30/277 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG A +++ +AK L A VD ++ Sbjct: 12 KPVEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPA--------- 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE-------- 115 D+E ++ A+IA P D+ A A A V + + Sbjct: 63 --DMEAMQEMVAAGLRARIAATARP---LARDIVAAEMANAHEVFMFLPTSALRMEQTLG 117 Query: 116 ------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLM-EGYGATCIYVVDS 168 + + GM + + PE L + + + + + D+ Sbjct: 118 ITRDQAISLFCSGAEEVCSRGMTLNLVFEDATRSRPEMLTEIVRQVHAQADVRRVILADT 177 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + R +++E+ + H H++ L VAN++AAV G + ++ G+G Sbjct: 178 VGCAIPAAMEALTRTVRSEIDADIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIG 237 Query: 229 AGAGNAPL-EVFIAAADKLGWQHGTDLYALMDAADDL 264 AGNA L E + L +HG D + L+ + + Sbjct: 238 ERAGNADLAETVAGLSLLLQREHGVDPHQLVALQEAV 274 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 177 bits (450), Expect = 4e-43, Method: Composition-based stats. Identities = 70/355 (19%), Positives = 128/355 (36%), Gaps = 23/355 (6%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQG----- 54 M + + I D TLRDG +S IA+ L + +VD IEVA +G Sbjct: 1 MTSRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAV 60 Query: 55 SSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 GA+ L+ IE V A I ++ G ++ L + Sbjct: 61 KKITDWAGANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEA 120 Query: 115 EADVSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++ A + G+ +L ++ E + + + I + D+ G Sbjct: 121 HFEDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLSTLPVKRILLPDTLGI 180 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + + + P+ H H++ LGVAN + A+ G + ++ GMG Sbjct: 181 LTPFESYTFIKEIVDR-YPDQHFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERT 239 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY----AG 286 GNAPL IA + + + + LV + ++ + AG Sbjct: 240 GNAPLASTIAVINDLMPECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQTAG 299 Query: 287 VYS-----SFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +++ + L + R+G L LGK E+ + D+ + L + Sbjct: 300 IHADGDKKNNLYFSKLMPERFG---RQRLYALGKTSGKANIENNLRDLGISLSDA 351 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 177 bits (449), Expect = 4e-43, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 115/318 (36%), Gaps = 30/318 (9%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 +L++ D TLRDG A +S + IA+AL +ARV +EV Sbjct: 8 RLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVG-----------IPAAGA 56 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA---- 120 ++ I A AD V A A ++ D+ A V ++ + + Sbjct: 57 GAIDDINAVADAV--AGRARIITWCRALPGDIALARACRVTGVHLSFPVSNIHMRIWGAT 114 Query: 121 ---------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ARE + P LA+ A A + + D+ G Sbjct: 115 PATVLASLDELTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADTVGF 174 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + L+ P +HAH++L L AN++AA G ++ G+G A Sbjct: 175 LTPDKTAGLTSHLRHA-APALPVEIHAHNDLGLATANTLAAFSAGASAASLTVNGLGERA 233 Query: 232 GNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSS 290 GNA LE + A G G D ++ + LV RPV V + + G A ++ S Sbjct: 234 GNAALEEVVMALKVAQGIDCGIDTSRFVELSA-LVARASRRPVPVQKPVVGAG-AFLHES 291 Query: 291 FLRHCETAAARYGLSAVD 308 + R D Sbjct: 292 GIHCAGLLRDRRSYEPFD 309 >UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH Length = 391 Score = 177 bits (448), Expect = 6e-43, Method: Composition-based stats. Identities = 74/342 (21%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG ++ R IA+AL A V +EV A Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVG-------------VPAMG 65 Query: 66 DLEW--IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 + E I A A V+K A ++ DL A + G + + +E +SA+ Sbjct: 66 EEERADIRAVAAVLKTA---APVVWCRLRAEDLAAAQRTGVVRLHIGVPVSERQISAKLG 122 Query: 124 Q---YAREL-----------GMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + R+ G + P LA+ A + GA + D+ Sbjct: 123 KDAAWVRDKVEKLVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTL 182 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G ++ + + H H++L + ANS+AA G + ++ G+G Sbjct: 183 GVLDPFAAHELVGRVVTRCP--LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGE 240 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYA 285 AGNA LE AA + G G L L ++ + RPL + V Sbjct: 241 RAGNAALEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECG 300 Query: 286 GVYSSFLRHCETA------AARYGLSAVDILVELGKRRMVGG 321 ++ T R+G S + +GK G Sbjct: 301 IHVDGLMKDRATYESADLRPERFGRSHR---IAIGKHSSAAG 339 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 177 bits (448), Expect = 6e-43, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 105/276 (38%), Gaps = 31/276 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K I D TLR+G +++ E+ +I L+ +++ IEV H G A Sbjct: 2 KPFQILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHP----------GISA 51 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 D E A + A+I L+ T+ ++ A +A A V + + + Sbjct: 52 L-DEEICRKVAQSARRAQI---LMHARATVEEVHAAKRAKADWVGIWASINDVSIQTKFR 107 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 Q + A++LG+ + + T E ++ GA I + D+ Sbjct: 108 HHEESYILEKVQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + E E + H H++ L AN++AA++ G IDA++ G+G Sbjct: 168 VGIWEPDTCKKIVTRAIEEFGCEIEV--HLHNDFGLAQANALAAIDAGASVIDATILGIG 225 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 AG L A KL H L + + + Sbjct: 226 ERAGITDLIQLTVALQKLRNDHRYSLDRIPELVQAI 261 >UniRef50_C5AMG4 MhpE-like protein n=1 Tax=Burkholderia glumae BGR1 RepID=C5AMG4_BURGB Length = 305 Score = 176 bits (447), Expect = 9e-43, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 97/243 (39%), Gaps = 3/243 (1%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + + D TLRDG + H +S + I L + VD IEV + Sbjct: 11 ARAVTLLDCTLRDGGYLNGHDFSAPQIDAILTRLLASGVDVIEVGYFRRRNVERHPSTVI 70 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 A ++ + A + + A ++ PG DL + VVR Sbjct: 71 ARCPPAFLASLART-QAVRYAVMVPPGDAEPADLDELAELPVSVVRFTCTDQNLPKVLAL 129 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + A LG+ + + LA + + G +Y DS GA+ ++ Sbjct: 130 GERAARLGLVVCANITRVSERSHSQLAALTRALAEAGFDTVYAADSNGALYPDEVAAIVG 189 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 ++ Q G HAH +L L AN++AA+ G +D ++ G+G G GNA +EV ++ Sbjct: 190 EMRRHFTG--QIGFHAHDSLHLAFANALAAMRAGASWVDGTIGGVGKGGGNAAIEVLLSE 247 Query: 243 ADK 245 K Sbjct: 248 LAK 250 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 176 bits (446), Expect = 1e-42, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 134/338 (39%), Gaps = 27/338 (7%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D TLR+GM A ++L+ +IA+++ + + + + +Y S++ Sbjct: 2 LTDDTLREGMQAPGIAFTLDEKIRIAQSISKSGI-----------KRALVSYPSAHESEV 50 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV-VRVATHCTEADVSAQHIQYA 126 E D+ +L G D+ + G++V + + + + ++YA Sbjct: 51 EAARKITDLHLFDDTYSL---GRSIKEDVDSIISTGSKVTLHLPFGDYDINKICDVVKYA 107 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 + ++ E + AK + GA+ + + D+ G + D +K Sbjct: 108 SDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVSYIKQ 167 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 LK + +H H++ L +ANSIA +E GCD +D ++ G+G G A + +K Sbjct: 168 NLK--VKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIADTASIASYLEKA 225 Query: 247 GWQHGTDLYAL---MDAADDLV------RPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 G++ + L D +L+ R D R L++ +S + Sbjct: 226 GYEDKINFEMLRKTYDLMSELILRKAGYRFFADNMPIFGRNVLSITAGTHSTSKVFPNSR 285 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + + ++ + ++ + E + + +++ Sbjct: 286 VSLNVYAGSR-LVASILRKNGIEPDERKVKLLVSKIKD 322 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 175 bits (443), Expect = 3e-42, Method: Composition-based stats. Identities = 77/342 (22%), Positives = 128/342 (37%), Gaps = 54/342 (15%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG +SL++ I + LD+ VD +E + Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGY-----------PLSN 50 Query: 64 HSDLEWIEAAADV-VKHAKIATLLLPGI-----GTIHDLKNAWQAGARVVRVA-----TH 112 D E+ D+ +KH K+ + ++ +GA VV + H Sbjct: 51 EKDAEYFRRVQDLNLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFH 110 Query: 113 CTE-------------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG 159 T+ AD A + RE+ D F PE A+ + G Sbjct: 111 VTDVLRVTLEENLAMIADSVAYIVGAGREVIYDAEHFF-DGWKANPEYAAETIRAAAKAG 169 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKP-ETQTGMHAHHNLSLGVANSIAAVEEGCD 218 A + + D+ G +I + A L G+H H++ L VANS+AAV+ G Sbjct: 170 ARMVVMCDTNGGSLPEEIAEYAAKAIAALTEFNVPVGIHTHNDGDLAVANSLAAVDAGAV 229 Query: 219 RIDASLAGMGAGAGNAPLEVFIA----------AADKLGWQHGTDLYALMDAADDLVRPL 268 ++ ++ G G GNA L IA G+QH T+L + ++ R Sbjct: 230 QVQGTINGFGERCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNR-- 287 Query: 269 QDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG-LSAVDI 309 ++ V + A G++ + AA+ Y + + Sbjct: 288 RNNQAFVGQSAFA-HKGGMH---VHAINRAASSYEHIDPQSV 325 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 174 bits (442), Expect = 3e-42, Method: Composition-based stats. Identities = 74/324 (22%), Positives = 118/324 (36%), Gaps = 38/324 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I+D TLRDG ++ QIA AL D VD IEV A Sbjct: 33 RVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGT-------------PAM 79 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 E EA + K ++ D+ +A +G +V ++ + ++A+ Sbjct: 80 GRDEQ-EAIRRIAKAGLPLRVIAWCRMRRGDVDDAIASGVSIVNLSAPVSRFQIAAKFGG 138 Query: 123 ------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 I YAR G++ S T + L + GA D+ G Sbjct: 139 SLPRVVAAVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLG 198 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ IR A++ + H H +L L AN++AA+E G ++ G+G Sbjct: 199 VLDPISIRAAIEAVRR--ITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGER 256 Query: 231 AGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYA 285 AGNAPLE A D L L AL ++ + R + V ++ Sbjct: 257 AGNAPLEQIAVALDSLFAQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESG 316 Query: 286 GVYSSFLRHCETAAARYGLSAVDI 309 L+ + A LS + Sbjct: 317 IHVDGILKSKDCYEA---LSPRRL 337 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 174 bits (441), Expect = 4e-42, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 108/285 (37%), Gaps = 33/285 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG + + +A+ + + + IE Sbjct: 30 IKIHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVSA------------ 77 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 E A +++VK + + D+K A G + + E Sbjct: 78 --EDARAVSEIVKRRLPTEIFGFARCMVDDVKRAADCGVSGIVIEIPSNEEMIREAYGWS 135 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGG 170 ++S + + A+ G+ TV F + + + K + G + VVD+ G Sbjct: 136 LEKAVELSVKATKAAQGAGLYTVFFPIDMTRANIDWVLKLIGQVAADGHMDALAVVDTMG 195 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + A+K+ + +H H + LGVANSI + G D + +++ G Sbjct: 196 GLAPHTVPYLIDAIKSRIDK--PLEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGER 253 Query: 231 AGNAPLEVF-IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR 274 AGNA E +A G+ G D Y+ + + L+R D PVR Sbjct: 254 AGNAAYEHLALALLTMYGYDLGLD-YSKIYSLSKLLRSFIDLPVR 297 >UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5 Length = 377 Score = 174 bits (440), Expect = 5e-42, Method: Composition-based stats. Identities = 56/305 (18%), Positives = 99/305 (32%), Gaps = 37/305 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLR+G ++ +IA+ L DA V IE H Sbjct: 4 KVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYS------- 56 Query: 65 SDLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------- 116 I+ D+ I + ++ D+ +A G + + ++ Sbjct: 57 ----AIKEIMDMKASGMINSEIIAHSRAVNSDIDSAASLGVDRIAIFYGVSDIHLDNKTH 112 Query: 117 -------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 D+ I YA G+ + T L + GA + + D+ Sbjct: 113 RSRTEALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTL 172 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + F L + H H+++ + +AN +AA E G I +++ G+G Sbjct: 173 GILTPEKTAYIFNNLSD--IKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGE 230 Query: 230 GAGNAPLEVFIAAADKLGWQHGTD------LYALMDAADDLVRPLQDRPVRVDRETLALG 283 G P + + + G D L L + + V T Sbjct: 231 RVGIIPTQALGVLLN---YHLGVDAINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTH 287 Query: 284 YAGVY 288 +GV+ Sbjct: 288 KSGVH 292 >UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT Length = 392 Score = 174 bits (440), Expect = 6e-42, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 104/323 (32%), Gaps = 41/323 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 D TLRDG + + + L V IEV + + Sbjct: 14 FVDTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKV------ 67 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA------- 120 ++ A + D A + G R V ++ ++ ++ Sbjct: 68 --------LLSLPVPAEIFPWLRPVEEDFDAALRLGFRRVHISFPTSDLHMAVLRRVGRE 119 Query: 121 QHIQYAR-------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + + R E G L + L K ++ G + D+ G + Sbjct: 120 ETLDRVRRAVCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHH 179 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 ++ +R AL +H H++L L AN++AA G + ++ G+G AGN Sbjct: 180 PLEMSERISAL---ASCGLPIEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGN 236 Query: 234 APLEVFIAAA--DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 A +E A G + G D L + L R L V + +G+ Sbjct: 237 AAMEEVAFALAFSGEGGETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGS-RIFHHSSGI 295 Query: 288 YSSFLRHCETAAARYGLSAVDIL 310 + + + Y L +++ Sbjct: 296 H---VDGVIKEPSNYELFPPELV 315 >UniRef50_C1YV80 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YV80_NOCDA Length = 328 Score = 172 bits (437), Expect = 1e-41, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 105/275 (38%), Gaps = 16/275 (5%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I DVTLRDG + +++ VR+ K L + V +EV + G Sbjct: 10 PRRPRILDVTLRDGGYLNDWRFTDATVREHTKVLGEVGVPYVEVGYISDDPGREPTL--- 66 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA---RVVRVATHCTEADVS 119 + + + A++ +L + ++ + A VVR+ D Sbjct: 67 -RCAPDLLRQVGEDAGPARVVAMLAVNGRSPDEVAALLRPRAEVLDVVRLTCLLERLDHV 125 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGGAMNMSDIR 178 + R G+ L+ P LA A+ + G A +Y+ DS GA+ Sbjct: 126 LAAAEAVRASGVTCSLNLISVTAYEPGELAGAAERVARAGVADWLYLADSRGALLPEHAA 185 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 + F ++A G H H NL VANS A+E G D +D SL G G G GN L Sbjct: 186 ELFAGVRAAWPGLA--GFHGHDNLGHAVANSRIALEAGFDLVDGSLHGYGLGGGNTDLAE 243 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPV 273 +A + D L A+ + + P Sbjct: 244 ALALVGE------VDRPRLASLAERVAAEMPPPPP 272 >UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM Length = 418 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 117/316 (37%), Gaps = 32/316 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ + D T+R+G + + + IAKALD+ +D IE+ F Sbjct: 37 PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL------------IPFL 84 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV-----------RVAT 111 + D E + D+ +AK+ + + D A + V +V Sbjct: 85 SKDDEEAAKELVDMGLNAKLLSFVSWKK---EDTDLALKLDLEGVVLDFVGNPWQGKVFW 141 Query: 112 HCTEADVSAQHIQ---YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++ + + YA++ G+ V + + + K + I + D+ Sbjct: 142 NLKPEEIIERGVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDT 201 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + LK +T +H H++ L A ++ AV G + + ++ G+G Sbjct: 202 YGDALPWAMEYVMKRLKKA-ADKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLG 260 Query: 229 AGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGV 287 G LE A + LG + +L L + + +V + V V++ + Sbjct: 261 ERVGLLSLEEIAVALEFLLGVKTNINLEKLYEIS-KIVEEISKVKVAVNKPIVGANQFKY 319 Query: 288 YSSFLRHCETAAARYG 303 + ++ A G Sbjct: 320 TAGWITWMHRKAREAG 335 >UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ Length = 355 Score = 171 bits (433), Expect = 4e-41, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 105/269 (39%), Gaps = 21/269 (7%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLR+G+ A +++E ++AK + +A VD V+H + Sbjct: 2 IIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESE------------ 49 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-VATHCTEADVSAQHIQYA 126 +E +V+ + G D+ GA + + + S I+YA Sbjct: 50 --VEVTRIIVERNYFKYVFGLGRALKEDIDLIASTGANISTYIPFEPQLVNKSLDVIKYA 107 Query: 127 REL----GMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + + N+ K AK +E G I + DS G + + Sbjct: 108 VNTYGKGKLIIEVGITNITAYELSNIVKLAKTLEELGVDRIQLADSLGKATPKLMYNIVN 167 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K +K +H H+++ VANSI++V G D +DA++ G+G G A L Sbjct: 168 NVKHTVK--IPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGERNGIADLATIAMI 225 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDR 271 ++ D L DA + L + + D+ Sbjct: 226 LRNDSYRINIDFEKLRDAYNYLAKLIIDK 254 >UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YPG1_9GAMM Length = 304 Score = 170 bits (432), Expect = 4e-41, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 120/299 (40%), Gaps = 19/299 (6%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG-- 60 + + I+DV RDG+ S+E Q+ A+ D V IEV + G Sbjct: 2 SETVVITDVGPRDGLQNQPQVLSVEQRLQLVNAIADCGVPQIEVGSFVSPKAVPAMAGTG 61 Query: 61 --FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD- 117 F A E++ ++ + K L + G V EA+ Sbjct: 62 QVFSALDAAEFVTPTIALIPNMKGYELARESGVKTVTMVVYASDGMAQKNVGMSMAEAEL 121 Query: 118 VSAQHIQYARELGMDTVGFLMMSH------MTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 V+ ++ A+E G++ + + ++ T P + GA + + D+ GA Sbjct: 122 VTLDILKLAKEDGIEVIATIAVAFECPFDGATDPAVVKNIVAKFLAAGADQLVLADTVGA 181 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG--- 228 + +R+ L A E Q G H H ++G+AN AAVE G R D+S+AG+G Sbjct: 182 AHPQQVRELTATLVASHGAE-QLGCHFHDTRAMGLANVYAAVESGIRRFDSSIAGLGGCP 240 Query: 229 ---AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY 284 +GN + ++G++ G DL LM A+D L + L +T GY Sbjct: 241 FSPGASGNVATDDIAMMLQQMGFKTGIDLGKLMQASD-LAQRLTGTAPGGRSKTWLQGY 298 >UniRef50_D1PP40 Putative uncharacterized protein n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PP40_9FIRM Length = 519 Score = 170 bits (432), Expect = 5e-41, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 109/287 (37%), Gaps = 13/287 (4%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH- 64 + + D TLRDG + ++ + R+I ++L A D +EV ++G + Sbjct: 4 IKLLDCTLRDGGYINDWRWGFGSARRIIQSLTRAGTDLVEVGFLRNVEGYDPDVTVCNTI 63 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 +L + H + + + I L G ++R+ H + + Sbjct: 64 EELNRLLPDEGQRGHTLYSGMAMRSNYDISKLSPYDGHGIELIRITAHDYDIRDGMDFAR 123 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 + G + ++L + +VD+ G+M D+ Sbjct: 124 EVKARGYKLSINPINIMGYNDKDLLWIFDQVNAIHPWQFSIVDTFGSMRRRDLERIVSLA 183 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIA 241 L P+ + G+H H N++L + +++ R +DASL GMG GN P+E+ Sbjct: 184 DHNLAPDIRLGLHLHENMALSFCLAQEFIDKPLLRDKTVDASLMGMGRAPGNLPIELVAD 243 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVY 288 ++ G H DL +MDA D + P++ GY Y Sbjct: 244 YRNETGSCH-YDLDEIMDAIQDHIAPIKGES--------EWGYTPAY 281 >UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectriaceae RepID=C7YY11_NECH7 Length = 398 Score = 170 bits (431), Expect = 6e-41, Method: Composition-based stats. Identities = 55/278 (19%), Positives = 109/278 (39%), Gaps = 32/278 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 I D TLR+G + E +IA+ALD+ V+ +E+ + S + Sbjct: 119 NFSIIDTTLREGEQFATAHFDTETKIKIAQALDEFGVEYLELTSPAASEQSKLD------ 172 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE--------- 115 +A + AKI + + D + A Q G + + + Sbjct: 173 -----CQAICKLGLKAKILCHI---RCNMDDARIAVQTGVDGINMCIGTSAQLMKHSHGK 224 Query: 116 -----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 A + + IQ+A+ G++ S + + K L++ GA + + D+ G Sbjct: 225 DLDWIAKKATEVIQFAQSHGVEVRFSGEDSFRSDFSEIIKLYSLVDRLGAQRVGIADTVG 284 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ ++ L+ + + + H H++ V+N+ A+E G ID ++ G+G Sbjct: 285 GATWREVDEKISTLRQVISCDIE--THFHNDTGCAVSNAFTALEAGATHIDTTVLGIGER 342 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYAL--MDAADDLVR 266 G L +A+ + + Y L + A ++LV Sbjct: 343 NGITSLGGLMASLMYSEHKSVLNKYKLEKLAALEELVA 380 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 118/339 (34%), Gaps = 48/339 (14%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+++ D TLRDG + S + +IA+ LD +D IE Sbjct: 2 STKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPG-----------A 50 Query: 63 AHSDLEWIEAAADV-VKHAKIATLLLPGIG-----TIHDLKNAWQAGARV---------- 106 + E+ A V +++AK+A T L +GARV Sbjct: 51 NPVETEFFNAMRGVGLRNAKLAAFGSTHHPSHTPETDPTLTALISSGARVAAVFGKSCPR 110 Query: 107 -VRVATHCTE------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG 159 V VA + S ++ E E + +G Sbjct: 111 HVEVALGISRERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALAVLRTAWEHG 170 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 A C+ + D+ G +I R ++ L P G+HAH++ L VANS+AAV G + Sbjct: 171 ADCLVLCDTNGGTMPEEISSIIRTVRERL-PHALLGIHAHNDCELAVANSLAAVNSGAIQ 229 Query: 220 IDASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDL-----VRPLQD 270 + ++ G+G GNA L I G L L A + + P + Sbjct: 230 VQGTVNGIGERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRR 289 Query: 271 RPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDI 309 +P + GV+ S + + AA + + Sbjct: 290 QPFVGNAAFA--HKGGVHVSAI--MKEAALYEHIDPSLV 324 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 169 bits (428), Expect = 1e-40, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 104/279 (37%), Gaps = 19/279 (6%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + E+ +IA+ALD+ V IE + Sbjct: 30 RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERAR 89 Query: 64 H--------SDLEWIEAAADVV-KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 H + A V + + LL + + A RV+ T Sbjct: 90 HQQWRHARITAFGSTRRAGGTVEEDVNLRLLLEAETPAVTIVGKASPFQVRVILGTTLDE 149 Query: 115 EADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A+ + + + G + + + P+ + GA + + D+ G Sbjct: 150 NLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALAVLRAACDAGADAVVLCDTNGG 209 Query: 172 MNMSDIRDRFRALKAELKP-ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 RA++ L G+H H++ L VAN+IAAV G + ++ G+G Sbjct: 210 TL---TDPLVRAVRHALSSVSCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGER 266 Query: 231 AGNAPLEVFIAAAD-KLGWQHGT--DLYALMDAADDLVR 266 GNA L I + KLG++ +L L + + + Sbjct: 267 IGNANLCSIIPILEYKLGYRCLPPGNLRKLTETSRYVAE 305 >UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clostridium RepID=NIFVA_CLOPA Length = 269 Score = 169 bits (428), Expect = 1e-40, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 110/280 (39%), Gaps = 32/280 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG S+++ +IAK + + V IE A Sbjct: 3 INIVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAG-------------IPAMG 49 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 E I + + + + + + D+ + + G +V +++ ++ Sbjct: 50 GDEKI-SVSKIAALGLPSKIAAWNRMSTKDIDTSIECGVDIVHISSPVSDLQIKTKLEKD 108 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 A+ + + YA E + L S L + +++ G + D+ G Sbjct: 109 RKWVAENLKRTVIYALEKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGI 168 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 M ++ + + ++ ++ + + H H++ + ++NS AA + G D ++ GMG A Sbjct: 169 MEPKELYSQIKKIRDKVPIDIEI--HVHNDFGMAISNSFAAFKAGAKFADCTITGMGERA 226 Query: 232 GNAPLEVFIAAADKLGWQHGT--DLYALMDAADDLVRPLQ 269 GN F+ +L + D +++ +++ + L+ Sbjct: 227 GNCDFLKFVKVIQELTGEKIYTGDFEDIIEKENEIKKILR 266 >UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3 Length = 547 Score = 168 bits (426), Expect = 2e-40, Method: Composition-based stats. Identities = 62/323 (19%), Positives = 106/323 (32%), Gaps = 28/323 (8%) Query: 1 MNGKK--LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 M KK L++ D TLRDG SL + IA+ LD + IE Sbjct: 1 MATKKTSLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQF 60 Query: 59 YGFGAHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV 109 + LE E A V + +L G + +W Sbjct: 61 FWQLQEEPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQ 120 Query: 110 ATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + + I Y R G + + P+ + GA + + Sbjct: 121 TSLAENLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMC 180 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQ------TGMHAHHNLSLGVANSIAAVEEGCDRI 220 D+ G I + ++ L + Q G+HAH++ VANS+ AVE G + Sbjct: 181 DTNGGTLPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMV 240 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHG-TDLYAL--MDAADDLVRPLQDRPVRVDR 277 ++ G G GNA L I +L + + L + + L+ + + Sbjct: 241 QGTINGYGERCGNANLCTLIPNL-QLKLDYDCIEPEKLAHLTSTSRLISEIVNLAPDDHA 299 Query: 278 ETLA----LGYAGVYSSFLRHCE 296 + G++ S ++ Sbjct: 300 PFVGRSAFAHKGGIHVSAVQRNP 322 >UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria RepID=Q1IM73_ACIBL Length = 520 Score = 168 bits (425), Expect = 3e-40, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 116/282 (41%), Gaps = 22/282 (7%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 G+ + ++D+ LRD ++ + ++E++ + LD+A S+E G++F+ Sbjct: 19 GRIIEVTDLILRDAHQSLMATRMAMEDMVPACEDLDNAGYWSLEC-----WGGATFDSCI 73 Query: 62 GAHSDLEW--IEAAADVVKHAKIATLLL----PGIGTIHD------LKNAWQAGARVVRV 109 ++ W + ++ K+ LL G D + A + G V RV Sbjct: 74 RFLNEDPWERLRQFKKLLPKTKLQMLLRGQNLLGYRHYEDSVVERFVAKAAENGMDVFRV 133 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFL--MMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I+ ++ G G + +S + T + AK ++ G I + D Sbjct: 134 FDALNDIRNLQTSIKAVKKTGKHAQGTISYTISPVHTITAFVEMAKQLKEMGCDSICIKD 193 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + D + +K + +H H + + + + AVE GCD +D +++ M Sbjct: 194 MAGLLKPQPAYDLVKGIKEACGDDMLVHVHCHATTGVTLVSLMKAVEAGCDMVDTAISAM 253 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL--VRP 267 G G+ P E F+ + G++ D+ ++ A +RP Sbjct: 254 CLGPGHNPTESFVEMLEGTGFETKLDMARILKARRYFEKIRP 295 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 167 bits (424), Expect = 4e-40, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 120/296 (40%), Gaps = 30/296 (10%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +L I DVTLRDG +S IAK L VD +E+A +G Sbjct: 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET----V 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH- 122 +EW E + + +I + G T+ +K +GARV+ + T + + Q Sbjct: 63 QKIIEWAET-EQLTERIEILGFVD-GNKTVDWIK---DSGARVLNLLTKGSLHHLEKQLN 117 Query: 123 -------------IQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVV 166 I+YA + G+ +L +P+ + K + I++ Sbjct: 118 KTPKEFFADVSIVIEYAIKNGLKINVYLEDWSNGFRNSPDYVEALVKHLSKERIERIFLP 177 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + +L + P H H++ L VANS+ A+ G + AS+ G Sbjct: 178 DTLGVLSPEETFQGVDSLVQK-YPNLHFEFHGHNDYDLSVANSLQAIRAGVKGLHASMNG 236 Query: 227 MGAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLA 281 +G AGN PLE + DK + + A+ +A+ LV + + +R + Sbjct: 237 LGERAGNTPLEALVTTIHDKSQAKTNINELAITEASR-LVEVFSGKRISANRPIVG 291 >UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB Length = 456 Score = 167 bits (424), Expect = 4e-40, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 102/275 (37%), Gaps = 37/275 (13%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D +LR+G I+ + +E +A+ + + VD IE H Sbjct: 5 IIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHPKISPYE------------ 52 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH----- 122 +E VV+ + + L D+ ++GA V + ++ + Sbjct: 53 --LERVRAVVRVSPLPVLAHA-RCRSEDIDAVAESGAAWVGMFASFNPVSLATKFGGMGK 109 Query: 123 ----------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 I+YA+ G+ + + T +L + + GA I DS GA+ Sbjct: 110 DQVLALFEASIRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGAL 169 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 S+ D L+ E + + Q H H++ L +A+S+ A+ G + I S G+G AG Sbjct: 170 LPSETYDILALLRHEFR-QVQFEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAG 228 Query: 233 NAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVR 266 A + + G D +D A L Sbjct: 229 VTDTFQLAALLESRFG-----DASRRLDKARQLSE 258 >UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=15 Tax=Bacteria RepID=Q2RIA5_MOOTA Length = 643 Score = 167 bits (424), Expect = 4e-40, Method: Composition-based stats. Identities = 73/341 (21%), Positives = 135/341 (39%), Gaps = 35/341 (10%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +L I+D TLRDG ++ + + ++ I + +D S+EV G++F+ Sbjct: 29 QLKITDTTLRDGHQSLWATRMTTADMLPIIEKIDSVGYHSLEV-----WGGATFDVCMRF 83 Query: 64 HSDLEWIEAAADVVKHAKIATL-------------LLPGIGTIHDLKNAWQAGARVVRVA 110 + W E + K+A+ L L P + A G ++R+ Sbjct: 84 LDEDPW-ERLRTLKKYARRTPLQMLLRAQSLVGYQLYPDDVVRAFIARAAANGIDIIRIF 142 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++ A++ G+ G ++ +S + T E+ K A +E G I + D Sbjct: 143 DALNDLRNMEVPVEAAKKEGVHVQGTVVYTISPVHTTEHYLKTALELESMGVDSICIKDM 202 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + + K +L +H+H+ L V + A G D +D + + Sbjct: 203 AGLLAPFEAYKLVKLFKEKL--HVPVQLHSHYIGGLAVGAYLEAARAGVDVVDTASVPLA 260 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRETLALGY- 284 GA P+E + A + + G DL L + A DDL R L V R T + Sbjct: 261 FGASQPPVETVVRALEGTPYDTGLDLNLLFEIARYFDDLRRELGYER-GVTRITDMWVFQ 319 Query: 285 ----AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + + A ++ ++L E+ + R G Sbjct: 320 HQVPGGMISNLVSQLKEQKAADRIN--EVLAEIPRVRADLG 358 >UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT Length = 543 Score = 167 bits (423), Expect = 5e-40, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 113/315 (35%), Gaps = 26/315 (8%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ + D TLRDG + +S E+ ++IA+ L +D IE + + F Sbjct: 8 RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASP--TDDCFFEL 65 Query: 64 HSDLEW-----------IEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 D W + +A L+ G + +W Sbjct: 66 MRDRAWSHSRLVAFGSTARPGHPASEDPGLARLVACGADAVCIFGKSWDLHVTTGLGIDL 125 Query: 113 CTEADVSAQHIQYARELGMDTVGF----LMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 T D+ + + + + L +DTV F + + + GA + + D+ Sbjct: 126 QTNLDLVRESVAWLK-LHVDTVLFDAEHFFDGYAANRDYAMQVLAAAADAGADSLVLCDT 184 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G I R + A P+ G+HAH++ + VAN+++AV G + ++ G+G Sbjct: 185 NGGSLPEQIGACVRQVVAR-YPDLTIGIHAHNDSEMAVANAVSAVSAGASHVQGTINGLG 243 Query: 229 AGAGNAPLEVFIAAAD-KLGWQHGT------DLYALMDAADDLVRPLQDRPVRVDRETLA 281 GN L I K+G G L L +++ L + + Sbjct: 244 ERCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQNAF 303 Query: 282 LGYAGVYSSFLRHCE 296 G++ S +R Sbjct: 304 AHKGGIHVSAVRKAS 318 >UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular organisms RepID=A1VTK3_POLNA Length = 744 Score = 167 bits (423), Expect = 5e-40, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 128/330 (38%), Gaps = 48/330 (14%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ IS+V RDG+ +++ + + AL A V IEVA Sbjct: 31 MYSPEILISEVGPRDGLQSVKACMPTADKLRWIDALYAAGVREIEVAS------------ 78 Query: 61 FGAHSDLEWIEAAADVVKHA-KIATL-LLPGIGTIHDLKNAWQAGARVVRVATHCTEAD- 117 F L + AA+VV+HA + L ++ + + A AG + V + A Sbjct: 79 FVPARLLPQMADAAEVVRHAITLPGLRVMALVPNRRGAEAALAAGVHKLTVPVSASAAHS 138 Query: 118 ------VSAQHIQYAR---------------ELGMDTVGFLMMSHMTTPENLAKQAKLME 156 + ++ R E G+ T + + +++ + A Sbjct: 139 LANVRRTREEMVEEVRAIAALRRDLAPHVGLEAGISTAFGCTLQGLVAEDDVIRLAAQCI 198 Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GA + D+ G N + +R FR L+AE+ H H+ LG+AN +AA EEG Sbjct: 199 AAGADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAG-AAHMHNTRGLGLANCLAAYEEG 257 Query: 217 CDRIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 DASL G+G +GN E + + +G + G DL L+ A L L Sbjct: 258 VRTFDASLGGLGGCPYAPGASGNVVTEDLVFMFEAMGLRTGIDLEKLIAARAPLKAGLPG 317 Query: 271 RPVRVDRETLALGYAGVYSSFLRHCETAAA 300 P+ AG+ F++ AA Sbjct: 318 EPLYGLTPE-----AGLPKGFVQGARMAAP 342 >UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM Length = 315 Score = 167 bits (422), Expect = 6e-40, Method: Composition-based stats. Identities = 57/292 (19%), Positives = 108/292 (36%), Gaps = 37/292 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ I +V LRDG+ + ++ E ++ + A IEV + + Sbjct: 1 MLPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEVG--SFMSPKAVPQM 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 E +E V A IA L ++ A G + V++ + A A Sbjct: 59 ANTDEVYEKLEKVPGVEYRALIANL--------RGVERAIACGCKKVKLNVSASRAHNLA 110 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPEN------LAKQAKLMEGYGA 160 + A+E G++ G + M+ + + +A + G Sbjct: 111 NLNRTPEESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKEIPIGAVASIVEAYMAVGI 170 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G +++ +K +H H+ LG+AN +A ++ G + Sbjct: 171 NEISLSDASGMAFPPQVQEICAYMKKHYPKNMWW-LHFHNTRGLGMANILAGMQSGFTQF 229 Query: 221 DASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR 266 D+S AG+G AGN E + ++ G G D ++ + + + Sbjct: 230 DSSFAGVGGCPFVPGAAGNVATEDVLNLCEESGIDTGIDFDKALEVSRRVAQ 281 >UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. G11MC16 RepID=B4BIN3_9BACI Length = 300 Score = 167 bits (422), Expect = 6e-40, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 101/280 (36%), Gaps = 31/280 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DV+ RDG+ + S E R + + L + + IE + Sbjct: 4 VQIIDVSPRDGLQNEQVIVSSEKKRMLIEMLVKSNIRKIEATSFV------HPLKVPQMA 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS------ 119 D E + + + ++ L +P + K + V AT Sbjct: 58 DAEQVLKLCEELSEIELVAL-IPNLKGFQRAKQTKISEINWVTAATETFNYKNIGMSIED 116 Query: 120 -----AQHIQYARELGMDTVGFLMMSHMT------TPENLAKQAKLMEGYGATCIYVVDS 168 Q +Q +R L + + +S +P + + GA I + D+ Sbjct: 117 NFAQFKQLVQESRTLNITICFSIAVSFGCPYEGKVSPVKVISLVERAIEAGANRIGIADT 176 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G +++ + + +H H +G+AN+ AA+E G + S +G+G Sbjct: 177 IGIATPKQVKELLTEVL-HIAKSIPIAIHLHDTRGMGLANAYAALEAGVKIFETSASGIG 235 Query: 229 ------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD 262 AGN E + +++G + G D L+DAAD Sbjct: 236 GCPFAPGAAGNLATEDLVYMFERMGVKTGIDFEKLLDAAD 275 >UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO Length = 495 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 105/307 (34%), Gaps = 30/307 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TL G + LE +IA LD VD IE +G Sbjct: 2 IRIFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGEKRVVREVVR- 60 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH--- 122 + + + D+K A + G V + + + + Sbjct: 61 ------NVKRLSRSGLSPEVCALARAIREDVKAAVETGVDSVNIFIPASRLLLERAYGMR 114 Query: 123 -----------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A+ + TV F + + L ++ E GA I + D GA Sbjct: 115 EEEARERVREAVSLAKSHDL-TVEFTAEDAGRSDDLLWDLCRIAEESGADRINLSDPVGA 173 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 M D + K ++ ++L + ANS++A G D+I S+ G+G A Sbjct: 174 MLPDDAKKIVLEAKKRIRKPISVTFS--NDLGMATANSLSAAIAGADQIHVSVNGLGPKA 231 Query: 232 GNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 G APLE + KL G + L ++ + R P+ + V AG Sbjct: 232 GIAPLEQVVVGLKKLAGLDTNVKMELLPSVSEAVERISGIPISEISPIVGPLVFTY-EAG 290 Query: 287 VYSSFLR 293 V+ S + Sbjct: 291 VHVSAIS 297 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I++V RDG+ + S+E+ + +AL + ++E + G Sbjct: 2 KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGSFVSPKAVPQMAG---T 58 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE--------- 115 DL + V++A + + + + A AGA VV V TE Sbjct: 59 DDLFALLPERSAVRYAGL-------VPNMKGYELAVAAGANVVNVVLSVTETMNQKNIRM 111 Query: 116 -----ADVSAQHIQYARELGMDTVGFLMMSHMT------TPENLAKQAKLMEGYGATCIY 164 +V I+ R G++ +L ++ P +A+ AK +E GA+ I Sbjct: 112 SLPQTVEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGASKII 171 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ GA N +R + +E+ + H H + +AN AA++ G D S+ Sbjct: 172 IADTIGAANPEHVRRLLNGVISEVGSDI-LSCHFHDTRGIALANITAALDHGIREFDTSI 230 Query: 225 AGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR 274 G+G GN E + + +G G + + L+ L L P+ Sbjct: 231 GGLGGCPFSPGATGNVATEDVVLLLNSMGHDTGINPFDLVPVVC-LAEQLTGVPLG 285 >UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS Length = 518 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 53/328 (16%), Positives = 109/328 (33%), Gaps = 30/328 (9%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K + DVTLRDG A+ ++ + + L V EV + + Sbjct: 4 TRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESVMEL 63 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 A + E +V K+ ++ L D++ W+A A R+ T + +S Sbjct: 64 AKLTAQMAEEGDEVAKNVVVSGL---ARCIESDIQRCWEAVQYAPHPRIHTFLATSPLSM 120 Query: 121 QHI-----QYARELGMDTVGFLMM----------------SHMTTPENLAKQAKLMEGYG 159 +++ + +E + V F + + + K + G Sbjct: 121 ENVLHMTPEQVKEKAVKCVKFAKSLVGDRGDVEFSAEHFGDCLENMDFVIDVLKAVVEAG 180 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 AT I + ++ D+ + + L +H H++L + A ++ + G + Sbjct: 181 ATTINLPNTVERYRPKLYVDQVKQVYEALPKNITISVHCHNDLGMATAATVESFFVGATQ 240 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 ++ +L G+G GN G G L + + A + P+ R + Sbjct: 241 LEVALNGLGERCGNTNFYEVAIGLHNSGVDTGLHLERIYETAILVSHWSGVPIYIRAPLI 300 Query: 276 DRETLALGYAGVYSSFLRHCETAAARYG 303 E + + + Y Sbjct: 301 GTEAIVHRSGIHQDGASKTKDMKKGAYR 328 >UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E183 Length = 345 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 100/258 (38%), Gaps = 17/258 (6%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D TLR+GM S + ++AK + A + + + Y S+ Sbjct: 2 LTDDTLREGMQTPGFAMSYDEKIELAKLISSAGI-----------KRALVAYPPAHKSEF 50 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV-VRVATHCTEADVSAQHIQYA 126 E A +V + G D+ + GA + + + ++I+YA Sbjct: 51 E---VTAAIVDGKYFQQVFGLGRTVKEDIDMINETGANISLHLPFKLDNMGQVYENIKYA 107 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 LG + M + E + K ME + + D+ G MN + I++ F A K Sbjct: 108 CTLGKIVEIGFVDIDMFSVEQITKFCHKMEELNVDVVQLPDTRGKMNPAAIKNVFEAAKK 167 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 + H H++ + VAN+I+A+ G D ID ++ G G G A K Sbjct: 168 A--TNIKIEAHCHNDYGMAVANTISAISAGVDYIDTTIFGTGERNGIADSITLADYLMKN 225 Query: 247 GWQHGTDLYALMDAADDL 264 + D+ ++ A + + Sbjct: 226 NLEKSLDIKGIIKAYNYV 243 >UniRef50_D0LRX4 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LRX4_HALO1 Length = 311 Score = 163 bits (413), Expect = 7e-39, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 110/260 (42%), Gaps = 5/260 (1%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + DVTLR+ A + + +++ +A+ L A++D +E+ + + Sbjct: 4 LLDVTLREVGEASGYAFDIDDAIGLAQQLSAAKLDGVEIGYVR--PRAWSGPPSAQTCSP 61 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYAR 127 +IE + A++A + L G ++R+A ++ + R Sbjct: 62 TYIERLRQALGSARLAVFVHLHEIPAGGLVALRPLGVDLIRLAVAADRPEILRERAAELR 121 Query: 128 ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAE 187 LG++ + P + + ++ E GA+ YV DS G++ L+ E Sbjct: 122 ALGIEFSVNAIRMTEHEPARIVELGRIAEDVGASMFYVADSNGSLYPLLFAKLAAQLRTE 181 Query: 188 LKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLG 247 L G H H NLSL +AN+I A+ G + ID SLAG G G GN E +A ++ Sbjct: 182 LS--IPLGAHLHDNLSLAMANAIVALSHGFEWIDGSLAGAGKGGGNLATE-RLALHLQVA 238 Query: 248 WQHGTDLYALMDAADDLVRP 267 L L D A++ +P Sbjct: 239 HGRRFGLAQLADLAEEWAQP 258 >UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella RepID=B0TW82_FRAP2 Length = 526 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 108/300 (36%), Gaps = 51/300 (17%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M+ KK+YI D TLRDG + S E+ A + +D +E Sbjct: 1 MDKKKIYIFDTTLRDGQQSPGAGMSFEDNIAYADLANKLNIDVLEAGFPS---------- 50 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIG---------TIHDLKNAWQAGARVVRVAT 111 +++D E + + + K + +++ G+ T+ L+ + G V + Sbjct: 51 -ASNTDFEIVNTISKRMAE-KNSNMIIAGLCQLRKNQVEITMDALRPSLAIGKARVHMYL 108 Query: 112 HCT----------------EADVSAQHIQYARELGMDTVGFLMMSHMT---TPENLAKQA 152 + I+ A + G + V F + T + + Sbjct: 109 PVDPNLAQASLGSKNDNEQNIKNVYELIKLASDQGFE-VEFSAEGYSRLGDTFDYVTDVF 167 Query: 153 KLMEGYGATCIYVVDSGGAMNMSDIRDRF--------RALKAELK-PETQTGMHAHHNLS 203 + G T I D+ G + + F +K E H H++L Sbjct: 168 RAAVSAGVTVINCPDTIGGACERENDNYFVKNMTKHAEIIKKEFPDKNIIWSAHCHNDLG 227 Query: 204 LGVANSIAAVEEG-CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD 262 L + NS+ AV +G +++ + G+G AGNA LE + + G Q Y ++ A+ Sbjct: 228 LALENSMNAVFDGPATQVEGCINGVGERAGNASLEQCVMFINLFGKQKDCHFYNDINIAN 287 >UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae RepID=B9YLN5_ANAAZ Length = 394 Score = 162 bits (410), Expect = 2e-38, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 108/310 (34%), Gaps = 41/310 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLR+G +S + IA+ LD +D IEV + + Sbjct: 2 IQILDSTLREGEQTPGVYFSPKTKLVIAQFLDRIGIDIIEVGNPAVDTEIAL-------- 53 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT----------- 114 I A+ AKI L I ++ A + + + Sbjct: 54 ---AINQIANAGLKAKIGAHSLCKI---DSVQKALDCDVDFLGIFFSVSPQRLYRDYNIC 107 Query: 115 ---EADVSAQHIQYARELGMD-TVGFLMMSHMTTP-ENLAKQAKLMEGYGATCIYVVDSG 169 D + I YAR D + + + +P EN+ AK GA I + D+ Sbjct: 108 LERAIDKIVEVISYARTQKSDLLIRYTPEDTVRSPIENVIAAAKAAVQAGANIISIADTT 167 Query: 170 GAMNMSD----IRDRFRALKAELKPET---QTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 G N I + +K EL E Q +H H++ L +AN + A G D ID Sbjct: 168 GYTNPFHPQRSIYFYVKTVKEELGKEGLYPQIEVHCHNDKGLALANVLDAYRAGADIIDV 227 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLGWQHGT-DLYALMDAADDLVRP---LQDRPVRVDRE 278 ++ G+G AG L + + + L L D D + V + Sbjct: 228 AVMGLGERAGIVDLAELLINLIDMDEEGNFWQLNYLKDLYDFVSEQSHISIPPHQAVTGK 287 Query: 279 TLALGYAGVY 288 YAGV+ Sbjct: 288 YAFTHYAGVH 297 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 162 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 102/301 (33%), Gaps = 38/301 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G ++LE ++IA +L VD IE+ DL Sbjct: 2 LIDTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGWVG-------------QDDL 48 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS-------- 119 A + L + D++ A + G + + + ++ + Sbjct: 49 ALFAGYARTLGGD--TALSVWSPCREKDIEVAAELGLKRINIGVPVSDLHIEKRLDSDRQ 106 Query: 120 ------AQHIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 A ++ A++ G + V L + A E GA+ + + DS G + Sbjct: 107 AILRKLAAAVRTAKDCGFEYVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQL 166 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + R + +L +H H + + ANS A+E G D D S+ G+G +G Sbjct: 167 TPLAMEKLVRKFREKL--HIDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSG 224 Query: 233 NAPLEVFIAAADKLGWQHGT------DLYALMDAADDLVRPLQDRPVRVDRETLALGYAG 286 A E +A D ++ AA + P V D G Sbjct: 225 IAATEELVARLALREGNTRYSTTVLKDACMVVGAAAKVAIPRTKAVVGTDIFACESGLHT 284 Query: 287 V 287 Sbjct: 285 H 285 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 106/291 (36%), Gaps = 35/291 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I +V RDG+ + + S+E ++ + + + IE + A + Sbjct: 13 VEICEVGPRDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKKL------VPAMA 66 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D E + AA + +IA L L + + A Q V+ + ++A + Sbjct: 67 DAEEVMAAWHRREGVRIAGLAL----SRSGITRALQTPIDVLHITISASDAFNKRNANKT 122 Query: 126 ARE-------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 E + T S E + + GAT + + Sbjct: 123 VAEGLSDLLPVVGEASTHLPVVTVISTSFGCPFSGDVQMETVFSVCESFLKAGATEMVLA 182 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G N + + R + G+H H+ LG+AN++A + G R D+++ G Sbjct: 183 DTTGMANPRQVAETVRGFYRTFGEDIPLGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGG 242 Query: 227 MG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 +G GN E + ++G GTDL L+ A + + + R Sbjct: 243 LGGCPFAPKATGNICTEDLVHMFHEMGIDTGTDLDGLITLAQQVEKWMGKR 293 >UniRef50_C5VE99 Pyruvate carboxylase subunit B n=3 Tax=Corynebacterium RepID=C5VE99_9CORY Length = 516 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 59/342 (17%), Positives = 134/342 (39%), Gaps = 28/342 (8%) Query: 1 MNGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ +K+ +++V LRD ++ + +LE++ +D A S+E G++F+ Sbjct: 24 MSPRKIGVTEVALRDAHQSLFATRMALEDMVAACDDIDKAGFWSVEC-----WGGATFDA 78 Query: 60 GFGAHSDLEW--IEAAADVVKHAKIATLLL----PGIGTIHD------LKNAWQAGARVV 107 ++ W + +++ ++++ LL G D ++ + + G V Sbjct: 79 CIRFLNEDPWKRLRTFRELMPNSRLQMLLRGQNLLGYRHYEDMVVDKFVEKSKENGMDVF 138 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYV 165 RV + + + +++G G + +S + + K A + GA I + Sbjct: 139 RVFDALNDPRNLERAMTAVKKVGGHAQGTICYTVSPLHDVDGYIKLAGQLLDMGADSIAL 198 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D + D R +K + Q +H H + + + A+E G D +D +++ Sbjct: 199 KDMAALLKPQPAYDIIRGVKDTYGDDVQINVHCHSTTGVTLVTLMKAIEAGADVVDTAIS 258 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL------VRPLQDRPVRVDRET 279 + G G+ P E + + G+ D+ L+ D R + + + Sbjct: 259 SLSLGPGHNPTESLVEMLEGTGYTADLDMDRLIKIRDHFKTIRPKYREFESKTLVDTNIF 318 Query: 280 LALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 L+ G+ S+ + A + +++ E+ + R G Sbjct: 319 LSQIPGGMLSNMESQLQAQGAGDRID--EVMEEVPRVRAAAG 358 >UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD Length = 389 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 111/303 (36%), Gaps = 36/303 (11%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLR+G R + + +IA+ LD + +EV G +D Sbjct: 17 IIDSTLREGEQFARGNFKTGDKIEIARLLDAFGAEFLEVTTP--------MVGAQTQAD- 67 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------------ 115 I + +AKI T + + D++ A G + + + Sbjct: 68 --IRRLTSLGLNAKILTHV---RCHLEDVQRAVDLGVDGLDLLFGTSSFLREFSHGKSIA 122 Query: 116 --ADVSAQHIQYARELG--MDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 D +++ I + ++ ++ + + +L + + G + + D+ G Sbjct: 123 QIIDTASEVIGWIKQNHPDLEIRFSAEDTFRSEEADLMAVYRAVSDLGVHRVGLADTVGV 182 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + R ++ + E H H++ V+N+ A+E G ID ++ G+G Sbjct: 183 ATPRQVYTLVREVRKVIHAECGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGERN 242 Query: 232 GNAPLEVFIAAADKLGWQHGTDLY--ALMDAADDLVRPLQDRPVR----VDRETLALGYA 285 G PL F+A Q D Y L+ D L+ L D P+ + E A Sbjct: 243 GITPLGGFLARMFTFDPQGLIDKYNLELLPELDRLIARLVDLPIPWNNYLTGEFAYNHKA 302 Query: 286 GVY 288 G++ Sbjct: 303 GMH 305 >UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO Length = 534 Score = 160 bits (406), Expect = 4e-38, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 92/263 (34%), Gaps = 37/263 (14%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 ++ D TLRDG ++ + IA+ LDD V IE Sbjct: 11 FHVFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPG-----------ANPR 59 Query: 66 DLEWIEAAADVV--KHAKIATL-----LLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 D E+ A + KHA++ H +K +GA+V+ + + V Sbjct: 60 DTEFFARARQEIDFKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHV 119 Query: 119 -----------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT 161 + H++ + PE + GA Sbjct: 120 ELALRTTLDENLAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGAD 179 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + + D+ G M + I+ + A+ + G+HA + VAN++AAV+ G + Sbjct: 180 VVVLCDTNGGMLPAQIQAVVATVLADTG--ARLGIHAQDDTGCAVANTLAAVDAGATHVQ 237 Query: 222 ASLAGMGAGAGNAPLEVFIAAAD 244 + G G GNA L +AA + Sbjct: 238 CTANGYGERVGNANLFPVVAALE 260 >UniRef50_Q1IEM5 Putative uncharacterized protein n=1 Tax=Pseudomonas entomophila L48 RepID=Q1IEM5_PSEE4 Length = 340 Score = 160 bits (406), Expect = 5e-38, Method: Composition-based stats. Identities = 82/335 (24%), Positives = 125/335 (37%), Gaps = 45/335 (13%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 + + D T RDG ++S V + VD +E+ + + + ++ Sbjct: 4 QTQSFVLMDCTFRDGGFQTDWRFSDAMVGRYFGMCQATGVDIVEMGYLNLDPAAGVSHLG 63 Query: 62 GAHSDLEWIEAAADV---VKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 + E + + + A ++ L QA A V+ A + + Sbjct: 64 SFKALPESLSDVQRQQVDLGPMRAAVMIDA----WRILDQPAQAAAEVIMAAIRRSPFPI 119 Query: 119 SAQHIQ-----------YAREL---GMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + I A+ L + + LM + TPE LA+ + T +Y Sbjct: 120 AILRIAAMSSQLAGSLALAKALAGQELAVMINLMQAAELTPEQLAQDLPALAVEPVTALY 179 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 DS G M + F + EL P G HAH N L VAN+ AA++ G D + Sbjct: 180 FADSFGRMLPEQVHRLFSRAR-ELTP-LPLGFHAHDNYGLAVANTQAALDAGARHADGTF 237 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY 284 AG+G GAGNAP E K G + + A + + + PL R T GY Sbjct: 238 AGIGRGAGNAPTETLG--LLKSGTREMAECEAFL---AEHIEPL--------RLTANWGY 284 Query: 285 AGVYSSFLRHC--ETAAARY-------GLSAVDIL 310 + Y S RH T A R GL +DIL Sbjct: 285 SPTYRSQARHNVHPTYAQRLFEGTPLTGLERIDIL 319 >UniRef50_C5CLY8 Pyruvate carboxyltransferase n=1 Tax=Variovorax paradoxus S110 RepID=C5CLY8_VARPS Length = 313 Score = 160 bits (406), Expect = 5e-38, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 135/304 (44%), Gaps = 41/304 (13%) Query: 1 MNGKK-LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ K+ ++I+DV RDG+ + E ++ + L +A + SIE A + + Sbjct: 1 MSAKEAIHITDVAPRDGLQNQAIRVGTEGKLRLIELLAEAGLRSIEAA--SFVSPKAVPQ 58 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA--- 116 A L ++A ++ + + + + L+ A AGA+ + V TE Sbjct: 59 MADAGELLPQVQARFAALRTSVL-------VPNLKGLERAHAAGAKEIAVVLSATETMNR 111 Query: 117 -----------DVSAQHIQYARELGMDTVGFLMMSHM------TTPENLAKQAKLMEGYG 159 +VS Q I AR LG+ T ++ ++ T + + + + M Sbjct: 112 KNINMGLDQATEVSEQTIAAARALGLRTRAYVAVAFDCPFEGETPLDEVLRLSARMHAAA 171 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 A I + D+ G+ + +++R AL+ + P + +H H +GVAN+ AA+E G R Sbjct: 172 ADEIVIADTIGSASPGQVKERILALRG-VVPIERLAVHLHDTRGMGVANAWAALEAGVRR 230 Query: 220 IDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA----DDLVRPLQ 269 DAS+ G+G AGN E + A++ G+ G L L+ A D+L RPL Sbjct: 231 FDASVGGIGGCPFAPGAAGNLATEDLVLMAERSGFATGISLAGLLAAVDFAQDELQRPLG 290 Query: 270 DRPV 273 R + Sbjct: 291 GRAI 294 >UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PWR8_9CLOT Length = 303 Score = 160 bits (405), Expect = 7e-38, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 110/291 (37%), Gaps = 34/291 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G ++ + +V RDG+ +++ E ++ K L DA + +E+ + Sbjct: 4 GDRIKVVEVGPRDGLQNLKNWIPTEVKIKLIKDLIDAGIKEMEMTSFVHPKA------IP 57 Query: 63 AHSDLEWI-EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------ 115 D E + +A D + +I T L + + K A+ G R + +E Sbjct: 58 QMKDAEAVTKAVIDELNEKEIRTFAL--VPNLVGAKKAYGCGLREITYVISASEKHNLAN 115 Query: 116 ------------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 AD+ A+ L + T + + + E G I Sbjct: 116 INRTVQQSLEGLADIRAELPDIQIRLDVATAFGCPFMGQVGEDLVINLIRSAEKIGINTI 175 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N + + + + E + G+H H +G+AN +AA+E G + S Sbjct: 176 TLCDTIGIANPKQVYELSQKVSKEFQ-NIPVGLHLHDTRGMGIANYLAAIEAGISVFETS 234 Query: 224 LAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 + G+G AGN E + +++ + DL AL+ + +L L Sbjct: 235 IGGLGGCPFAPGAAGNTATEDLVNMLNEIKVETNIDLNALVSISKELEEKL 285 >UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PPD2_9SPIO Length = 624 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 115/305 (37%), Gaps = 39/305 (12%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ ISD+ LRD ++ + + ++ I LD S+E G++F+ Sbjct: 4 KVRISDLVLRDAHQSLHATRMTTADMLPICSKLDSVGYWSLEA-----WGGATFDACIRF 58 Query: 64 HSDLEW--IEAAADVVKHAKIATLLL----PGIGTIHD------LKNAWQAGARVVRVAT 111 ++ W + + + + I LL G D +K A G V R+ Sbjct: 59 LNEDPWERLRSLHKALPNTPIMMLLRGQNLLGYRHYADDVVDAFVKAAADNGVGVFRIFD 118 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMSHMTTP----ENLAKQAKLMEGYGATCIYVVD 167 + + A++ G + +S TTP + A+ AK +GA I + D Sbjct: 119 ALNDPRNLKRAADAAKKTGKHVQ--MAISFATTPYHTIDKYAELAKTYTEFGADSICIKD 176 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + D D A+K K +H H L VA + A E G D +D +++ M Sbjct: 177 MAGLLKPFDAFDLVTAIKK--KTSIPINIHTHATTGLSVATLLKAAEAGADILDTAISSM 234 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGV 287 G ++P E + G D+ L++ A R ++ YA Sbjct: 235 SMGTSHSPTETMVEIFRGTEMDTGLDINLLLEIAA-YFREVRK------------HYAQF 281 Query: 288 YSSFL 292 SSFL Sbjct: 282 ESSFL 286 >UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8 Length = 381 Score = 159 bits (402), Expect = 1e-37, Method: Composition-based stats. Identities = 55/306 (17%), Positives = 111/306 (36%), Gaps = 36/306 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D T+RDGM + SL +++ K ++ ++S+EV ++ F H Sbjct: 2 IRIQDNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDE-----FNIHQ 56 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ---- 121 + + ++V L I + + VV++ ++ + + Sbjct: 57 FRDILSPEKELV------VLTRLNEKEIKKIVK-LKIHNLVVKILLPISDLHIKEKLNFS 109 Query: 122 ---HIQYARE---------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +IQ ++ G+D T+ E L + +++ Y + D+ Sbjct: 110 NKYYIQKIKDCLDILKKDKKGVDICF--EDGTRTSREKLKEYMEIISKYQVRTVTFADTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + D F + H H++L L AN++AA+ G +I+ + G+G Sbjct: 168 GCSTPLEYGDIFNYFVKKYS-NIIFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGE 226 Query: 230 GAGNAPLEVFIAAADKLGWQ----HGTDLYAL-MDAADDLVRPLQDRPVRVDRETLALGY 284 AGNAP+E I K + D+Y ++ + L + + + Sbjct: 227 RAGNAPIEEIITILTKKQIESTEFTLPDVYKTSINISKILDFQISENKPIIGENIFKHES 286 Query: 285 AGVYSS 290 Sbjct: 287 GIHQDG 292 >UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA Length = 303 Score = 159 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 113/293 (38%), Gaps = 37/293 (12%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN +K+ I +V RDG I+ ++ +I +L++A + IE+ +SF Sbjct: 1 MNLPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEI--------TSFVN 52 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 ++ E VK + ++ ++NA +GA V+ V +EA Sbjct: 53 PKWIPQMVDSKEICETCVKKNERKYEVIVLCPNKKGIENAISSGAEVISVVISVSEAHNK 112 Query: 120 AQHIQYARE------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGAT 161 A + E L + TV PE +++ + + G Sbjct: 113 ANVNRTVEESFKELEEMVYKYPNMKFRLDLATVFGCPFGEEIKPERVSELIEKAKKIGVK 172 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 I + D+ G N + + +K ++ E +H H +G+AN + A++ G + Sbjct: 173 EIMLADTVGLGNPVLVEKILKQVKEQVGTENII-LHIHDTRGMGLANMLVALQLGYSIFE 231 Query: 222 ASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYAL---MDAADDLV 265 S+ G+G AGN E F+ + +G H L L +D D V Sbjct: 232 TSIGGLGGCPFAPGAAGNVATEDFVNMLNGMGINHNIHLEKLYHTLDLIDQYV 284 >UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ Length = 435 Score = 158 bits (400), Expect = 2e-37, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 114/326 (34%), Gaps = 14/326 (4%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + DVTLRDG A+R + L+ I K L V IEV + Sbjct: 42 FFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCSRLSSIA 101 Query: 67 LEWIE---AAADVVKHAKIA--TLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 + + + V K KI+ + IH + + V + + ++ Sbjct: 102 PDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKVLEKISE 161 Query: 122 HIQYARELG--MDTVGFLMMSHMTTPENL---AKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + +A+ L + F + ENL + + YGA I + ++ Sbjct: 162 SVSFAKSLVGSKGEIQFSGEHFGDSLENLDFAVEAFRTALNYGADIINLPNTVERYRPWL 221 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 +A++ L + +H H++L + A ++ + G +++ +L G+G AGN Sbjct: 222 FVSMVKAVRNVLPENAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLGERAGNTNT 281 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAGVYSSFL 292 A G +L A+ + + + P+ ++ V + ++ Sbjct: 282 YEVAIALHNCGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVISHRSGIYQDGVA 341 Query: 293 RHCETAAARYGLSAVDILVELGKRRM 318 + + Y ++ + R+ Sbjct: 342 KTRHLSKGAYRAFNATLIGRPEEDRI 367 >UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI Length = 311 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 115/314 (36%), Gaps = 47/314 (14%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ + +V RDG+ ++ + Q +AL +A + +E+ F Sbjct: 17 PKKVTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTS------------FV 64 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 + + ++ A+++V+ + + + + + V V + + Sbjct: 65 SPKWVPQMKDASEIVESCLNSERDIVLAPNRKGVDRVLETKGKAVAVFVGVSNSFNKKNI 124 Query: 117 --------DVSAQHIQYARELGMDTV------GFLMMSHMTTPENLAKQAKLMEGYGATC 162 + + +E G + P+ + + G Sbjct: 125 NKTTAESLEELKPIVGELKEKGYFVRACISTSFYCPYEGKIPPQETLQLCREFVDMGVDE 184 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + V D+ G N + + F LK L PE H H + +AN +A+++ G DR D Sbjct: 185 LSVADTIGMANPKESFELFSLLKKTL-PEVLMTAHFHDTRKMALANILASLQAGVDRFDT 243 Query: 223 SLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD 276 S G+G +GNA E + ++G + G DL +L AA +LV P R + Sbjct: 244 SAGGLGGCPFAPGASGNAATEDVVFMLHQMGIETGVDLDSL-TAAVNLVAPHLSRTIDT- 301 Query: 277 RETLALGYAGVYSS 290 GY + +S Sbjct: 302 ------GYYKLQTS 309 >UniRef50_B0TEI2 Oxaloacetate decarboxylase, alpha subunit n=27 Tax=cellular organisms RepID=B0TEI2_HELMI Length = 643 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 63/340 (18%), Positives = 135/340 (39%), Gaps = 31/340 (9%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I++ TLRDG ++ + LE++ I + +D S+EV G++F+ Sbjct: 5 RRVKITETTLRDGHQSLWATRMRLEDMLPIVEKMDKVGYHSVEV-----WGGATFDVCMR 59 Query: 63 AHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 ++ W + + + LL P + A + G ++R+ Sbjct: 60 YLNEDPWERLRILKKYFRRTPLQMLLRGQSLVGYTHYPDDVVEAFVHKAVENGIDIIRIF 119 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + +++A++ G ++ +S + T E+ + A + GA + + D Sbjct: 120 DALNDIRNMEAPMRHAKKAGAHVQAAIVYTISPVHTMEHYVETALQLAEMGADSLCIKDM 179 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + R+ +K ++ +H H+ + V + VE G D ID + + Sbjct: 180 AGLLLPFKSRELVTLIKEKV--NLPLQLHTHYIGGMAVGALLKGVEAGADIIDCASLPLA 237 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRETLALGYA 285 G P+E + A + G D++ + + +DL + L + + + Sbjct: 238 FGPSQPPVETLVRAFSDTPYDPGLDIHRIFEITQYFEDLRKRLGYKRGITGLNDMLVFDH 297 Query: 286 ----GVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ ++ + E AR+ L+ D+L E+ K R G Sbjct: 298 QVPGGMITNLITQLEEQKARHRLN--DVLHEMPKVRADFG 335 >UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT Length = 532 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 91/269 (33%), Gaps = 11/269 (4%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKAL-DDARVDSIEVAHGDGLQGSSFNYGF- 61 K++ I D TLRDG + IA+ L D VD IEVA +G Sbjct: 13 KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMLLHDINVDRIEVASARVSEGEKDAVARI 72 Query: 62 ----GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD 117 L+ +E V + + + G I+ L + Sbjct: 73 CRYAKTIGKLDSVEVLGFVDNNKSVDWIAECGGHVINLLAKGSYKHCTQQLKMSPEEHLA 132 Query: 118 VSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNM 174 Q I YA G +L + + L + + D+ G +N Sbjct: 133 HIKQTIGYALSKGFTVNLYLEDWSSGMRDSRDYLFMMMDELVKQPIKRFLLPDTLGILNP 192 Query: 175 SDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNA 234 + R + P + HAH++ L V+NS+AAV G + ++ G+G GNA Sbjct: 193 LQCVEYMRQMVRR-YPNSHFDFHAHNDYDLAVSNSLAAVLSGAKGLHVTVNGLGERCGNA 251 Query: 235 PLEVF-IAAADKLGWQHGTDLYALMDAAD 262 PL + D + L D + Sbjct: 252 PLASVQVILKDMFEAKTNIKEDRLNDISR 280 >UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT Length = 304 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 94/302 (31%), Gaps = 41/302 (13%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 D T+RDG + + I L V IEV D Sbjct: 20 FVDTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPC-------------LGDH 66 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS-------A 120 E IE ++ L D ++A G + V V+ ++A + Sbjct: 67 E-IEDLRALLSLPVPVELFPWLRPLEADFESALGLGFKRVHVSFPTSDAHRASVQNMGRP 125 Query: 121 QHIQYARE-------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 ++ R+ G L + + L + + G + D+ G + Sbjct: 126 DIVERVRKTVLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHH 185 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 ++I +R L E +H H++L + AN+++A G + ++ G+G AGN Sbjct: 186 PAEIIERISELSKE---GLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGN 242 Query: 234 APLEVFIAAADK------LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 A +E A L DL L + L R L V Sbjct: 243 AAMEEVAFALACERGDPSLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHS 302 Query: 284 YA 285 Sbjct: 303 SG 304 >UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI Length = 506 Score = 157 bits (398), Expect = 4e-37, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 96/273 (35%), Gaps = 12/273 (4%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKAL-DDARVDSIEVAHGDGLQGS---- 55 M + + I D TLRDG +S +A+ L + +VD +E+A G Sbjct: 1 MKRRYIEIMDTTLRDGEQTSGVSFSASEKLALAQLLLTEVKVDRVEIASARVSAGELEAV 60 Query: 56 -SFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 + ++ +E V A + L G ++ L T Sbjct: 61 QQITRWADSIGLIDKVEVLTFVDGQASLDWLQASGAKVMNLLTKGSLNHLTHQLKKTPGE 120 Query: 115 EADVSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 Q + A +LG+ +L +P+ + + + + + D+ G Sbjct: 121 HFTDIGQVVCAAGKLGVKANVYLEDWSNGMRNSPDYVFQYLDFLNTQPILRVLLPDTLGV 180 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + ++ L P HAH++ L +AN + A+ G I ++ G+G A Sbjct: 181 LTPAESYSFVHQLVTR-YPNLHFDFHAHNDYDLSIANVMEAIRAGAHGIHLTVNGLGERA 239 Query: 232 GNAPLEVFIAAADKL--GWQHGTDLYALMDAAD 262 GNAPL IA + G +L + Sbjct: 240 GNAPLASAIAVLRDFMPEVRTGVVEKSLYQVSK 272 >UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT Length = 577 Score = 157 bits (397), Expect = 5e-37, Method: Composition-based stats. Identities = 65/391 (16%), Positives = 114/391 (29%), Gaps = 89/391 (22%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ D TLRDG S E+ +IA LD + IE Sbjct: 6 SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPG-----------A 54 Query: 63 AHSDLEWIEAAA-DVVKHAKIATLLLPGIGTIHDLK-------------------NAWQA 102 D+++ D +K ++I H +W Sbjct: 55 NPKDVQFFWQLQEDPLKLSQIVAFCSTRRPHTHAADEPMLQDILAAGSSWVTIFGKSWDL 114 Query: 103 GARVVRVATHCTEADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYG 159 T + I++ R G + + + + K G Sbjct: 115 HVTTGLKTTLEENLAMIRDTIEFFRSQGRRVIYDAEHWFDGYKHNRDYALQTLKAAMAAG 174 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKA--------------------------------- 186 A + + D+ G ++ + + Sbjct: 175 AEWLVLCDTNGGTLPHEVSQIVQDVVKVTRDWGRINSKLDQSGQVVSEEVEKSTNSLPNT 234 Query: 187 -----ELKPETQ-TGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 L G+H H++ + VAN++AAV G + ++ G G GNA L I Sbjct: 235 QYPIPNLPFPIPQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLI 294 Query: 241 AAAD-KLGWQHGTD--LYALMDAADDLVRPLQ----DRPVRVDRETLALGYAGVYSSFLR 293 KLG+ T+ L L +A+ + + + V R A G++ S + Sbjct: 295 PNLQLKLGYSCITEHQLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFA-HKGGIHVSAV- 352 Query: 294 HCETAAARYG-LSAVDILVELGKRRMVGGQE 323 E Y + + G RR + E Sbjct: 353 --ERNPLTYEHIQPEQV----GNRRRIVISE 377 >UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO Length = 662 Score = 156 bits (395), Expect = 9e-37, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 114/344 (33%), Gaps = 34/344 (9%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 D TLRDG + + ++ +A+ L V IE + + S L Sbjct: 67 YDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTSSGLA 126 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHD--LKNAWQAGARVVRVATHCTE----------- 115 AAA K A G+ D LK A V + + Sbjct: 127 D-RAAAGGTKLAAFGMTRRRGVTADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLGVSP 185 Query: 116 ------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + S H+ A + + PE K A GA + + D+ Sbjct: 186 EENIAMIEESVAHLVAAGKEVLVDCEHYFDGRKANPEFAVKCAAAAAKSGAKFVVLCDTN 245 Query: 170 GAMNMSDIRDRFRALKAEL---KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G D+ + R +K + + G+H H++ SL VANSIAAV G + + G Sbjct: 246 GGTLPWDVEEFTREVKEAVDATGADCSVGIHCHNDTSLAVANSIAAVRGGATMVQGCVNG 305 Query: 227 MGAGAGNAPLEVFIAAAD-KLGWQHGTD-----LYALMDAADDLVRPLQDRPVRVDRETL 280 G GNA L V A + K+G + L + A L QD + Sbjct: 306 YGERTGNADLLVVAANLELKMGRTALPEGSLQRLTQVSAAVAKLCSQHQDPRQPYMGSSA 365 Query: 281 ALGYAGVYSSFLRHCET-----AAARYGLSAVDILVELGKRRMV 319 G++ + L+ G A ++ EL R + Sbjct: 366 FAHKGGLHVAALQKMPASYNHIVPTLVGNEARSVISELSGRGNI 409 >UniRef50_A1WEM7 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WEM7_VEREI Length = 332 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 111/292 (38%), Gaps = 44/292 (15%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+++ + +V +RDG+ A + + AL DA + IE F Sbjct: 12 GRRIALHEVGMRDGLQAETAFVPTDEKIALIDALADAGMRKIEAT------------AFV 59 Query: 63 AHSDLEWIEAAADVVKHA--KIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 + + + A+ V++ + + + + A AGA + + +E+ A Sbjct: 60 SPQAIPALRDASAVLRAIGRRPGVIYSALVPNAGGAERAIDAGADELNLVMSASESHNLA 119 Query: 121 QHIQYARELGMDT----------------------VGFLMMSHMTTPENLAKQAKLMEGY 158 ++ R + G M M+ L A+ +E + Sbjct: 120 N-LKMTRAQSFEALSGVSRIARQARVRVNISLSCSFGCPMEGDMSEATVLDGCARFIEQF 178 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 GA + + D+ G + AL+A P T+ +H H +G+AN +AA++ G Sbjct: 179 GAQGVTLCDTTGMAYPGQVFALTCALRARW-PGTELTLHFHDTRGMGLANVMAAIDAGAT 237 Query: 219 RIDASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 D SL G+G +GN E A + +G+ G DL L+ AA L Sbjct: 238 HFDVSLGGLGGCPYAPGASGNVCSEGIAHALECMGYDTGIDLALLIAAAQRL 289 >UniRef50_C5A1I6 Pyruvate carboxylase subunit B (PycB) n=18 Tax=Archaea RepID=C5A1I6_THEGJ Length = 595 Score = 154 bits (389), Expect = 4e-36, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 128/337 (37%), Gaps = 34/337 (10%) Query: 5 KLYISDVTLRDGMHA-IRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ I D T RD + I + + +++ +IA+ +D S+EV G++F+ Sbjct: 3 KVDIIDTTFRDAHQSLIATRLTTDDMLKIAETMDRIGFYSMEV-----WGGATFDVCIRY 57 Query: 64 HSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 + W + + ++ K+ LL P ++ A + G + R+ Sbjct: 58 LKEDPWERLRLLREHIRKTKLQMLLRGQNVVGYKHYPDDVVEKFVELAHKNGIDIFRIFD 117 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMSH--MTTPENLAKQAKLMEGYGATCIYVVDSG 169 + I+ A+E+G + G + + + T E K+ + + I + D Sbjct: 118 ALNDVRNMEVAIRKAKEVGAEVQGAIAYTTGKVFTLEYYMKKVEELLKLDVDVITIKDMA 177 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + I + +K +H H + VA + VE G D ID +++ + Sbjct: 178 GLLTPWKIYELVSEIKETYG--IPVNVHTHSTTGMAVAVYLKGVEAGADYIDTAISPLAF 235 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRET------LALG 283 G ++ A + H D + + L + L+++ + + L Sbjct: 236 GTAQPGIQTIWHALPEAVGSH-LDRELIHRVSRYLKKLLEEKYWGLLHKETLIVNPYVLK 294 Query: 284 Y---AGVYSSFLRHCETAAARYGLSAVDILVELGKRR 317 Y G++S+ + + A L ++L E+ + R Sbjct: 295 YQVPGGMFSNLIAQLKEMNALDRLD--EVLEEIPRVR 329 >UniRef50_D1B6M4 Pyruvate carboxylase n=2 Tax=Synergistaceae RepID=D1B6M4_THEAS Length = 507 Score = 154 bits (389), Expect = 5e-36, Method: Composition-based stats. Identities = 65/342 (19%), Positives = 129/342 (37%), Gaps = 32/342 (9%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +++ I++ RD +I + E++ IA+A+D S+EV G++F+ Sbjct: 44 PRRIGITETAFRDAHQSIMATRLRTEDMIPIAEAMDQVGYHSMEV-----WGGATFDACM 98 Query: 62 GAHSDLEWIEAAADVVK--HAKIATLLL----------PGIGTIHDLKNAWQAGARVVRV 109 + W + + K+ LL +K A G ++R+ Sbjct: 99 RFLDEDPWERLRELRRRMPNTKLQMLLRGQNLVGYRHYADDVVREFVKRAVGNGIDIIRI 158 Query: 110 ATHCTEADVSAQHIQYARELG--MDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + G + +S + T E+ KQA+ M GA I + D Sbjct: 159 FDALNDLRNMEVAADQVKREGAHLQLAISYTISPVHTLESFVKQAEDMVSMGADSICIKD 218 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G ++ ++ A+K+ + +H+H+ +A++ G D +D +++ Sbjct: 219 MAGLLSPTEAGKLVSAIKSRIG-RVPLQVHSHYTSGFAAMTYLASIMAGADVVDCAISPF 277 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR-------VDRETL 280 G E +AA + G L L+ A+ R L+++ + VD L Sbjct: 278 SMGTSQPATETMVAALAGGAFDTGLSLEKLLPVAEHFSR-LREKYSKLIMGVQGVDINIL 336 Query: 281 ALGY-AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+YS+ + A + L ++L E+ + R G Sbjct: 337 IYQVPGGMYSNLQSQLKEQGALHKL--REVLEEVPRVRKEMG 376 >UniRef50_B0T0Z5 Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B0T0Z5_CAUSK Length = 301 Score = 154 bits (388), Expect = 5e-36, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 107/290 (36%), Gaps = 28/290 (9%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + I +V RDG+ ++ + + L+ A IEV G Sbjct: 2 SRFIQIVEVGPRDGLQNEALSLPVDEKLALIRRLEAAGAKRIEVVSFVNPNRVPQMAGA- 60 Query: 63 AHSDLEWIEAAADVVKHAKIATL--------LLPGIGTIHDLKNAWQAGARVVRVATHCT 114 E + A ++H++I + + ++ G + T T Sbjct: 61 ----EEIMAALKPDLEHSRIGLVLNMRGWERCVAAQCDEANVVVCATDGFGLANQGTTAT 116 Query: 115 EADVSAQHI--QYARE------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + I + A E + + + + + + G I + Sbjct: 117 QQVDALAAIVERQAVEGGPPITMTLSVAFGCPFDGEVSEDQVVAIVREAASMGVPEIAIA 176 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + +R R A++A P+ + +H H + G+AN+ A VE G D +DAS+ G Sbjct: 177 DTIGVADPWTVRRRVEAVRAA-APDVRLRLHFHDTRNTGLANAYAGVEAGVDVLDASVGG 235 Query: 227 MGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 +G GN E + ++ G++ G DL AL++ D+ L Sbjct: 236 LGGCPFAPNATGNIGTEDLVYMLERAGFETGYDLSALIEIGRDISARLGK 285 >UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE Length = 312 Score = 153 bits (387), Expect = 7e-36, Method: Composition-based stats. Identities = 53/290 (18%), Positives = 101/290 (34%), Gaps = 35/290 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + +++V+ RDG I E I + + + V +IEV + Sbjct: 15 VTLTEVSPRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVTSFVSPKA------IPQMK 68 Query: 66 DLEWI-EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D + E A + K+ + + L I + + A G R V + Sbjct: 69 DAAIVAEYAVAMAKNTDVNIMAL--IPNVKGAERALSCGIRKVNYIISASPLHNKKNMNR 126 Query: 123 ---------IQYARE-------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + LG+ T +++ + G + Sbjct: 127 TPQESFEALCELKKNFPEADVTLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSFTLC 186 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G N + +K + Q +H H+ + +AN AA+ +G DR ++++ G Sbjct: 187 DTIGVANPRQVETLLHEVKKNFS-DIQLALHLHNTHGMALANIYAAMLQGVDRFESAIGG 245 Query: 227 MG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 +G AGNA E + +++ DL L+D A+ +R L Sbjct: 246 LGGCPFAPGAAGNAATEDLVNMLNRMEINSNIDLAKLLDVANQ-IRELVP 294 >UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Tax=cellular organisms RepID=B4U857_HYDS0 Length = 619 Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats. Identities = 74/339 (21%), Positives = 133/339 (39%), Gaps = 37/339 (10%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +KLY +DV+LRDG+ ++ + E++ + LD S+EV G++F+ Sbjct: 2 EKLYFTDVSLRDGIQSLLATRVRTEDMLPALEILDKCGFWSLEV-----WGGATFDVCLR 56 Query: 63 AHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 + W ++ ++ K+ K+ LL P +K ++ G V R+ Sbjct: 57 YLKEDPWERLKQFKNITKNTKLEMLLRGQNIVGYRNYPDDVVEAFVKKSYDNGVEVFRIF 116 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + I+ + L G L S + T E K AK + G I + D Sbjct: 117 DALNDVRNMRKAIETGKSLNAIVKGVLSYTTSPVHTVEYYVKIAKDLVNMGIDIISIKDQ 176 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANS--IAAVEEGCDRIDASLAG 226 G + D +ALK E K +H H + +AN + A+E G D + Sbjct: 177 SGILTPKMAFDLVKALKQEFK----LPIHIHTQTTAELANMSQLKALEAGATMFDTAFYS 232 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR-------PVRVDRET 279 + + + E I + G+Q D AL + A ++ R ++ + P D Sbjct: 233 LSSQTSHPSGETMIHVFKEFGYQIDVD-QALYEEAGNVFREVRKKYKKYDTLPPYPDVSV 291 Query: 280 LALGY-AGVYSSFLRHCETAAARYGLSAVDILVELGKRR 317 L G+ S+F+ + L ++L E+ + R Sbjct: 292 LTHQVPGGMISNFISQLKEQNLEDKLE--EVLKEVARVR 328 >UniRef50_C0WJX1 Possible pyruvate carboxylase n=1 Tax=Corynebacterium accolens ATCC 49725 RepID=C0WJX1_9CORY Length = 518 Score = 152 bits (385), Expect = 1e-35, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 140/341 (41%), Gaps = 34/341 (9%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + +K+ I D TLRD +I + + ++ + + +A + H D + F+ Sbjct: 27 SERKINIIDTTLRDAHQSIWATRMTTSHILSLLDDITNAGFE-----HVDLVAPIQFDVS 81 Query: 61 FGAHSDLEWIE------------AAADVVKHAKIATL-LLPGIGTIHDLKNAWQAGARVV 107 + W +++ +A+ LP ++ + + G RV+ Sbjct: 82 VRYLKEDPWERVRLVHENAAPGTKFRALIRSKNLASFDFLPDDAILNWTERLYANGFRVI 141 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFL--MMSHMTTPENLAKQA-KLMEGYGATCIY 164 + D Q ++ A+ELG +T G L +S + T + ++A +L+E I Sbjct: 142 GSFDGLNDIDNIDQGLKLAKELGAETFGALSYCLSPVHTDDLYKRKATELLERTDVDRIM 201 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+GG + ++ A+++ + + +H H L + A E G D I S+ Sbjct: 202 LKDAGGLLTPDRLKTLIPAIRSSIG-DVPLEVHTHSLTGLSPLTYLYAAELGVDSIHTSI 260 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL---QDRPVRVDRETLA 281 A + G G + + LG+ D +D+A + ++ + +D+PV V R Sbjct: 261 APLANGPGQPATQAVVRDLRALGYTVDVD-DERIDSASERIQEIADTEDKPVGVPRAFDG 319 Query: 282 LGY-----AGVYSSFLRHCETAAARYGLSAVDILVELGKRR 317 L Y G+ ++F ETA G ++L E+ + R Sbjct: 320 LHYMHQLPGGMLTNFESQLETAGL--GDRFEELLYEVARVR 358 >UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD Length = 373 Score = 152 bits (385), Expect = 1e-35, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 97/288 (33%), Gaps = 37/288 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G E +IA + D V+ IE+ Sbjct: 2 LIDTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGWMGQEGLD------------ 49 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS-------- 119 E + L + D+ A + + ++ ++ Sbjct: 50 ---EVVKALRGRGVTCDLSVWSPCRTVDVYRAAGLSIDTINIGLPVSDLHIAERLRTDRD 106 Query: 120 ------AQHIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + A G+ + L + A++ + GA I + D+ G M Sbjct: 107 GLTRMLRETVGLAHSCGIRRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVM 166 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + I + R + + + +H H++ + AN+I A+E G D S+ G+G +G Sbjct: 167 TPTRIAELVRFFAQSV--DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSG 224 Query: 233 NAPLEVFIAAADKLGWQHGTDLYA--LMDAADDLVRPLQDRPVRVDRE 278 + LE G D+Y L+ A DLV PV +R Sbjct: 225 ISALEEVAGHLR---LVQGYDIYDMNLVRALCDLVAEYARIPVARNRP 269 >UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular organisms RepID=PYCB_METTH Length = 568 Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 130/344 (37%), Gaps = 38/344 (11%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + + + RD ++ + ++ IA+ +D S+E G++F+ Sbjct: 2 KGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEA-----WGGATFDTCIR 56 Query: 63 AHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 ++ W + + VK I LL P ++ +++ G V R+ Sbjct: 57 YLNEDPWERLRELKEHVKRTPIQMLLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIF 116 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + I+ ARE G + +S T E+ A+ +E + + D Sbjct: 117 DALNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFARELEALECDSVAIKDM 176 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ D + RALK E + +H H + + AA E G D +D +++ + Sbjct: 177 AGLISPHDAYELVRALKEE--TDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLS 234 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR------PVRVDRETLAL 282 GA P E +AA + G DL ++ ++ + P+ +T L Sbjct: 235 WGASQPPTESIVAALRDTPYDTGLDLE-ILKNIKKYFEEIRKKYSSILDPIAEQIDTDVL 293 Query: 283 GY---AGVYSSFLRHC--ETAAARYGLSAVDILVELGKRRMVGG 321 Y G+ S+ + + A RY ++L E+ + R G Sbjct: 294 IYQIPGGMLSNLVAQLKEQNALDRY----EEVLEEMPRVRKDMG 333 >UniRef50_Q7NM88 Oxaloacetate decarboxylase alpha chain n=1 Tax=Gloeobacter violaceus RepID=Q7NM88_GLOVI Length = 508 Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 129/339 (38%), Gaps = 29/339 (8%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ ++D T RD ++ + + + +A ++ S+EV G++F+ Sbjct: 21 RVGVTDTTFRDAHQSLLATRMTTAQMLPVASRMNRIGFHSMEV-----WGGATFDACIRF 75 Query: 64 HSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 + W ++ + ++ L+ P ++ + G ++R Sbjct: 76 LGEDPWERLKVLRREMPDTRLQMLVRGQNLLGYRHYPDDIVERFIRRSVANGIDIIRTFD 135 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + I+ +E G G L+ +S + ++ A+ + G + + D Sbjct: 136 ALNDVRNMRKTIETGKECGAHVQGTLVYTVSPVHDVDHYMAVARDLVAMGIDSLCIKDMA 195 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + RAL+ + MHAH + A++ G + +D +++ + Sbjct: 196 GLLKPDAAGRLVRALRPVVGTLLPIQMHAHSLSGMASMAYWEAIQMGANAVDTAISPLAL 255 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPLQDRPVR---VDRETLALG 283 G+ E + + G D+ AL+D A + + R + P+R +D L+ Sbjct: 256 GSSQPATETMVVVLRDTPFDTGLDIDALVDVAESIERIFRDAGNAPIRQTIIDTRVLSHQ 315 Query: 284 Y-AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ ++ L + A + L ++L EL + R G Sbjct: 316 VPGGMITNLLAQLDQQRASHRL--QEVLRELPRVRADFG 352 >UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD Length = 421 Score = 152 bits (383), Expect = 2e-35, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 118/326 (36%), Gaps = 18/326 (5%) Query: 6 LYISDVTLRDGMHAIRH-QYSLENVRQIAKALDDARVDSIEVAHGD-GLQGSSFNYGFGA 63 + I+D TLRDGM A ++E R + + + V ++ + G Sbjct: 30 VEINDETLRDGMQATAVTSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVVTLAR 89 Query: 64 HSDLEWIEA---AADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 H E + A H+ I ++ + G+ +R + D Sbjct: 90 HIREEALRLEPNCAARTLHSDIVPIVEAVQRAGQPIVVHTFIGSSPLRQCAEAWDLDFIL 149 Query: 121 Q----HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + I +A G++ + +TPE L + +GA+ + + D+ G + Sbjct: 150 RSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPAG 209 Query: 177 IRDRFRA---LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 R R L L + H H++ L + N++ A+E G R+ G+G GN Sbjct: 210 TRALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTGN 269 Query: 234 APLEVFIAAADKLGWQHGTDLYALMD----AADDLVRPLQDRPVRVDRETLALGYAGVYS 289 AP+E+ + LGW DL L+D A P+ V + GV+S Sbjct: 270 APVELLLLNLKLLGW-IDQDLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAFRTA-TGVHS 327 Query: 290 SFLRHCETAAARYGLSAVDILVELGK 315 + + + + V G+ Sbjct: 328 AAIIKALERGDDWLADHIYSSVPAGE 353 >UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasilense RepID=NIFV_AZOBR Length = 376 Score = 152 bits (383), Expect = 2e-35, Method: Composition-based stats. Identities = 73/348 (20%), Positives = 128/348 (36%), Gaps = 52/348 (14%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M G + I+D RDG ++L+ IA+ALD+A V +E+ Sbjct: 1 MAGSTI-INDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIG-----------IP 48 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 + E I A A + A++ +HD ++ A ++ ++ ++ Sbjct: 49 AMGREERERIRAVASLGLKARLMVWCR-----MHDTDLKARSTAVAPSLSVPVSDIHITK 103 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + ++ AR+ G++ S + L A + + Sbjct: 104 KLNGSRAWALREIERKVKTARDHGLEVSLGGEDSSRADMDFLIAAATVAQR---PRFRFA 160 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVAN---SIAAVEEGCDRIDAS 223 D+ G ++ + + G HAH L A ++AAV G ++ + Sbjct: 161 DTLGVLDPFQHARL---HLTAAATDPEIGYHAH-TPRLANATAWVTLAAVLGGATHVNTT 216 Query: 224 LAGMGAGAGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVRPLQDRPVRVD----RE 278 + G+G AGNAPLE + + L G G D AL A DLV +RPV V+ R+ Sbjct: 217 VNGLGERAGNAPLEEVVVSLKVLYGQDCGVDTRAL-GAISDLVERASNRPVAVNKSIVRD 275 Query: 279 TLALGYAGVY-----SSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 + AG++ + + R+G S + R G Sbjct: 276 AVFTHEAGIHVDGLLTDRAPTRISTPPRWGASTASCWASIPARGGEDG 323 >UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1 Length = 554 Score = 151 bits (381), Expect = 4e-35, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 126/366 (34%), Gaps = 39/366 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA-- 63 + D TLRDG ++ + IA+ LDD V IE L + + Sbjct: 17 FQVYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRARTE 76 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGI-----GTIHDLKNAWQAGARVVRVATHCT---E 115 + + A + + P + + ++ R V A + Sbjct: 77 LTLRNAVLVAFGATRKPESRVEADPQVLALLEAETPAVCLVAKSHVRHVSEALRTSLDEN 136 Query: 116 ADVSAQHIQYARELGMDTV---GFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + + R G + P+ + ++ GA + + D+ G M Sbjct: 137 LAMIRDTVAFFRREGRRVFLDAEHFFDGYAADPQYAVECVRVAAESGAEVVVLCDTNGGM 196 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 I D + G+H H + VAN++AAV+ G ++ + G G G Sbjct: 197 LPPRIADVVHEVAERTG--VPLGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGYGERCG 254 Query: 233 NAPLEVFIAAAD-KLGWQHGTDLYALMDAAD--DLVRPLQDRPVRVDRETLAL----GYA 285 NA L +A + K+G + L + + + ++P R ++ + L A Sbjct: 255 NANLITVVANLELKMGRRV-LPPGRLAELGRVSHAIAEVANQPPRANQPYVGLSAFAHKA 313 Query: 286 GVYSSFLR-----HCETAAARYGLSAVDILVELGKRRMV-----------GGQEDMIVDV 329 G+++S ++ + A G ++ E+ R V GQ D + + Sbjct: 314 GLHASAIKVSPDLYQHIDPALVGNDMRMLVSEMAGRASVELKSRQLGFDLSGQRDAVSRI 373 Query: 330 ALDLRN 335 ++N Sbjct: 374 VERVKN 379 >UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MGG7_RHOM4 Length = 311 Score = 151 bits (381), Expect = 4e-35, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 108/297 (36%), Gaps = 38/297 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I +V RDG E + + L +A V I+V +D Sbjct: 9 ICEVGPRDGFQYETTFIPTERKVAVIERLVEAGVRRIQVTSFV------HPKWVPQMADA 62 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD---------- 117 E + + L L + ++ A AG R V ++ + Sbjct: 63 EEVCRRLPDRDDVIFSGLAL----NVKGVERAHAAGLRYVDLSIATHDEHSLANANMTVA 118 Query: 118 ----VSAQHIQYAR------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I+ A +LG+ TV T + + + A+ G + D Sbjct: 119 EAVRQAEAMIRLAHHYDMQPQLGLQTVFGYKQPGDTPLQRIRELARRFVDLGLESFSLAD 178 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + I++ A++ E+ +T +H H +G+AN +AA++ G R D SL G+ Sbjct: 179 TTGMAHPVQIQEYVEAVREEIG-DTPLVLHLHDTRGMGLANVLAALQCGVTRFDTSLGGL 237 Query: 228 G------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRVDR 277 G GN E + + +G + G D + + A +L L ++ P R R Sbjct: 238 GGCPFIPGATGNIATEDTVYMLEAMGVRTGIDYRRVAELALELEAFLGKELPGRQTR 294 >UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD Length = 314 Score = 150 bits (380), Expect = 5e-35, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 109/306 (35%), Gaps = 37/306 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I +V RDG+ R ++ + L DA + ++E Sbjct: 19 PERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEATSFV------HPKWVP 72 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 +D E + A + L+ L A AG V V TE+ Sbjct: 73 QLADAEELLARLRRRDGVRYPVLV----PNERGLDRALAAGVTHVAVFASATESFARRNL 128 Query: 117 --------DVSAQHIQYARELGMDTVGFLMMSHMTTPE------NLAKQAKLMEGYGATC 162 + I ARE G+D G++ M E + + + G T Sbjct: 129 NSGLDAQFAMFEPVIARAREAGLDVRGYVSMCFGDPWEGIVPTEQVVTVGRRLLDAGCTQ 188 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D+ G + + A +H H +AN++AA+ +G +DA Sbjct: 189 LSLGDTIGVATAAAVERLLDAFIEGGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDA 248 Query: 223 SLAGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRV 275 S G+G GN E + D LG +HG DL AL++ + + R L + P RV Sbjct: 249 SAGGLGGCPYAESATGNLATEDLVWLLDGLGVEHGVDLDALVETSRWMSRQLGRSSPSRV 308 Query: 276 DRETLA 281 R Sbjct: 309 VRALSG 314 >UniRef50_B1G528 Pyruvate carboxyltransferase n=2 Tax=Proteobacteria RepID=B1G528_9BURK Length = 319 Score = 150 bits (380), Expect = 6e-35, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 109/294 (37%), Gaps = 26/294 (8%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-------- 53 +K+ + +V LRDG+ +R S E + + + +A IEV + Sbjct: 3 TREKVTVREVGLRDGLQMVRTILSTEQKLEWCRRMVEAGSVEIEVTSFVPPKIVPQFADA 62 Query: 54 -----GSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKN----AWQAGA 104 G+ G A + + ++ A + + H+LKN ++ Sbjct: 63 VEVARGALDITGLHAAALVPNLKGAQRAFEVGLSKVHYVLSASNEHNLKNVRRTTAESVE 122 Query: 105 RVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 R+ + +A+ I G+ T +S + + + GA I Sbjct: 123 DFARIVLERDTVERTARRITLG--AGVATAFGCTISGRVEESGVLGLVETLLEAGADEIT 180 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ G N ++ R + A + + H H LG+AN +AA++ G D+SL Sbjct: 181 IADTVGYANPRQVKALMREVLA-ITRDVPVACHFHDTRGLGLANVVAALDAGVRSFDSSL 239 Query: 225 AGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP 272 G+G GN E + + G+ G ++ AL+ + + L P Sbjct: 240 GGLGGCPFAPNATGNINTEDTVFLLESEGFDTGINIDALLAIRETIAGWLPGEP 293 >UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria RepID=A8ZRW8_DESOH Length = 681 Score = 150 bits (378), Expect = 9e-35, Method: Composition-based stats. Identities = 73/349 (20%), Positives = 132/349 (37%), Gaps = 42/349 (12%) Query: 6 LYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 L I D++LRDG ++ + E++ +A +D+ ++EV G++F+ Sbjct: 25 LKIMDLSLRDGHQSLFATRGRTEDMLPVAGLMDEVGFWAVEV-----WGGATFDTMHRFL 79 Query: 65 SDLEW--IEAAADVVKHAKIATLLL----PGIGTIHD------LKNAWQAGARVVRVATH 112 ++ W I K ++ LL G D ++ A + G V R Sbjct: 80 NEDPWERIRTLKRYFKKTPLSMLLRGQNLVGYRNYADDVARAFVERAAENGMDVFRTFDA 139 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSHMTTP---------ENLAKQAKLMEGYGATCI 163 + ++ ++ G G + S MT P E +AK +E GA I Sbjct: 140 LNDFRNFETVVEVIKKCGKHFQGTICYS-MTEPRLGGEVYNVEYFVTKAKELESMGADTI 198 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D G + DI + +ALK +KP H+H L + + AVE G D +D Sbjct: 199 CIKDMAGLVAPYDIFNVVKALKESVKP--PIHFHSHFTSGLAPMSHLKAVEAGVDILDTC 256 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR--------PVRV 275 L+ + +E + + G D+ L++ + L + + + V Sbjct: 257 LSPYAYRTSHPAVEPMVMSLLGTNRDTGFDINKLVEITEILEEKVMPKYRQFLNEPTMSV 316 Query: 276 DRETLALGY--AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 + L G+ S+ + A L+ ++ EL + R GQ Sbjct: 317 IDINVLLHQTPGGMLSNLFGQLKEMDALDRLN--EVYKELPRVRKDLGQ 363 >UniRef50_B2A6U5 Conserved carboxylase region n=10 Tax=Bacteria RepID=B2A6U5_NATTJ Length = 633 Score = 149 bits (376), Expect = 1e-34, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 110/291 (37%), Gaps = 23/291 (7%) Query: 6 LYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I+D +LRD ++ + ++ I + +D+ S+E+ G++F+ Sbjct: 3 VKITDTSLRDAHQSLFATRMRTGDMVPILETIDNVGFHSLEM-----WGGATFDSCMRFL 57 Query: 65 SDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 + W + VK+ K+ LL P +K G ++R+ Sbjct: 58 DEDPWERLRVIRKYVKNTKLQMLLRGQNIVGYKNYPDDVLEEFIKKTVANGMDIIRIFDA 117 Query: 113 CTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + I++ + G G + +S + + AK ++ G I V D G Sbjct: 118 VNDLRNMEKAIEFTKREGAHAQGTICYTISPVHNNNVFVQFAKDLKETGCDSICVKDMAG 177 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ D + LK E+ +H+H + I ++E G D +D +++ G Sbjct: 178 LLSPYKGYDLVKRLKEEVG--LPVQIHSHSTSGMATTTYIKSIEAGADIVDTTISPFALG 235 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLA 281 P+E A + + D AL + + + + ++ + + + Sbjct: 236 TSQPPVEPVEAMLSETEKELELDGDALTEMS-EYFKGMKKKYEKYSKLAFT 285 >UniRef50_Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit n=56 Tax=Bacteria RepID=5S_PROFR Length = 505 Score = 149 bits (375), Expect = 2e-34, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 132/341 (38%), Gaps = 30/341 (8%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +++ I+++ LRD ++ + ++E++ +D A S+E G++++ Sbjct: 11 PREVGITELVLRDAHQSLMATRMAMEDMVGACADIDAAGYWSVEC-----WGGATYDSCI 65 Query: 62 GAHSDLEW--IEAAADVVKHAKIATLLL----PGIGTIHD------LKNAWQAGARVVRV 109 ++ W + ++ ++++ LL G +D + + + G V RV Sbjct: 66 RFLNEDPWERLRTFRKLMPNSRLQMLLRGQNLLGYRHYNDEVVDRFVDKSAENGMDVFRV 125 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLM--MSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + A + ++ G G + +S + T E K A + GA I + D Sbjct: 126 FDAMNDPRNMAHAMAAVKKAGKHAQGTICYTISPVHTVEGYVKLAGQLLDMGADSIALKD 185 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + D +A+K +TQ +H H + + + A+E G D +D +++ M Sbjct: 186 MAALLKPQPAYDIIKAIKDTYGQKTQINLHCHSTTGVTEVSLMKAIEAGVDVVDTAISSM 245 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY--- 284 G G+ P E + G+ D L D + ++ + + + +TL Sbjct: 246 SLGPGHNPTESVAEMLEGTGYTTNLDYDRL-HKIRDHFKAIRPKYKKFESKTLVDTSIFK 304 Query: 285 ----AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ A + +++ E+ + R G Sbjct: 305 SQIPGGMLSNMESQLRAQGAEDKMD--EVMAEVPRVRKAAG 343 >UniRef50_A6LCK8 Carboxylase, putative n=7 Tax=Bacteroidales RepID=A6LCK8_PARD8 Length = 525 Score = 148 bits (374), Expect = 2e-34, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 116/327 (35%), Gaps = 37/327 (11%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +KL I D+TLRDG + + S + ++ DA ++EV G G Sbjct: 3 RKLLIRDLTLRDGQQSAFATRMSQAQIDRVLPYYKDAGFYAMEVWGGAVPDSVMRYLGEN 62 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 LE I+ + +K++ L P +N+ ++G ++R+ Sbjct: 63 PWDRLEIIKE--KIGNSSKLSALSRGRNLFGYNPYPDEIIEGFCRNSIRSGIDIMRIFDA 120 Query: 113 CTEADVSAQHIQYARELG--MDTVGFLMMSHMTTP--------------------ENLAK 150 + D I+Y ++ G D + +P E Sbjct: 121 LNDVDNVKSTIRYVKKFGGKADCAICYTIDPHHSPVERIKAALHGRPLHKPVFTNEYFLN 180 Query: 151 QAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSI 210 +A +E GA I + D G + + + R K LK H H G+A+ + Sbjct: 181 KALQLESLGADMITLKDMSGLIPPARTAELVRLFKKSLK--VPVDFHTHCTPGYGLASVV 238 Query: 211 AAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 +A+ G D +D ++ G +E+ KLG + D+ A+ +L+ ++ Sbjct: 239 SAIINGVDIVDTNIWNFAGGPAAPAVELVYIFCKKLGIELDLDMDAIAKINKELLTIRKE 298 Query: 271 RPVRVDRETLALGYAGVYSSFLRHCET 297 V + + V SF + Sbjct: 299 LSVFDTAKKFPRPFNPVEDSFPAEIDR 325 >UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK Length = 338 Score = 148 bits (373), Expect = 3e-34, Method: Composition-based stats. Identities = 61/332 (18%), Positives = 111/332 (33%), Gaps = 41/332 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+ ++I+DV +RDG+ + + ++ IE + Sbjct: 9 GESVWINDVVMRDGLQMEPVFVPTSEKVALIDEIGHCGLNRIEATSFTSAKA------IP 62 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV---- 118 A SD E + + V + A L+L G + A + G + + +E Sbjct: 63 ALSDAEAVMHEIERVPGVRYAALVLNRRG----AERALECGVDELNLGVSASETHNLANT 118 Query: 119 ---SAQHIQYARELG------------MDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 AQ ++ ++ + T M +++ G I Sbjct: 119 RMTRAQAVRALLDITAFCRDRLAIGVSIATAFGCPMEGAIDIDSVLDIGNQFVAAGVRGI 178 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N ++ AL A + + +H H+ +G+AN +A ++ G DAS Sbjct: 179 TLCDTTGMANPRQVKAVCGALAARWR-GIELTLHLHNTRGMGLANVVAGLDAGIRHFDAS 237 Query: 224 LAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDR 277 L G+G +GN E + D +G+ G DL L+ A V Sbjct: 238 LGGLGGCPFAPGASGNICTEDLVHMLDAMGYATGVDLERLIACARR-----MPGLVGHGV 292 Query: 278 ETLALGYAGVYSSFLRHCETAAARYGLSAVDI 309 F + A R A ++ Sbjct: 293 PGQVQHAGAWDHRFPPPADLEATRERALAREL 324 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfi... 290 6e-77 UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacte... 289 7e-77 UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteri... 287 4e-76 UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocar... 284 4e-75 UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bac... 274 2e-72 UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Prot... 272 2e-71 UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bact... 270 4e-71 UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea Rep... 268 2e-70 UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta pr... 267 4e-70 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 265 1e-69 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 265 1e-69 UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseud... 261 3e-68 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 259 1e-67 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 258 2e-67 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 258 2e-67 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 257 3e-67 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 257 4e-67 UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octade... 256 6e-67 UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseob... 256 8e-67 UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales... 256 1e-66 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 254 3e-66 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 253 5e-66 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 253 6e-66 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 253 7e-66 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 252 2e-65 UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio ... 251 3e-65 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 251 3e-65 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 251 4e-65 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 250 5e-65 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 250 5e-65 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 250 5e-65 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 249 9e-65 UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellul... 249 1e-64 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 249 1e-64 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 249 1e-64 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 248 2e-64 UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase... 246 9e-64 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 246 1e-63 UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkho... 246 1e-63 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 244 5e-63 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 244 5e-63 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 243 7e-63 UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 243 7e-63 UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salin... 243 7e-63 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 242 1e-62 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 242 2e-62 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 241 3e-62 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 240 5e-62 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 240 7e-62 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 239 1e-61 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 239 1e-61 UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimon... 239 1e-61 UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ... 239 1e-61 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 239 1e-61 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 237 4e-61 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 237 5e-61 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 236 6e-61 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 236 1e-60 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 236 1e-60 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 235 1e-60 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 235 2e-60 UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora ... 234 2e-60 UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 233 6e-60 UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methano... 232 9e-60 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 232 1e-59 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 231 2e-59 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 231 2e-59 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 231 3e-59 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 230 5e-59 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 230 6e-59 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 230 7e-59 UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodoco... 229 1e-58 UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methyla... 227 5e-58 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 227 6e-58 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 226 7e-58 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 226 7e-58 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 225 2e-57 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 224 3e-57 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 224 3e-57 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 224 5e-57 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 222 2e-56 UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 221 3e-56 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 220 5e-56 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 219 1e-55 UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=... 218 2e-55 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 217 3e-55 UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrige... 217 6e-55 UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota... 215 2e-54 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 215 2e-54 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 214 4e-54 UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=M... 213 7e-54 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 213 7e-54 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 213 8e-54 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 212 1e-53 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 211 3e-53 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 210 6e-53 UniRef50_B0TEI2 Oxaloacetate decarboxylase, alpha subunit n=27 T... 210 8e-53 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 209 1e-52 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 208 3e-52 UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase... 208 3e-52 UniRef50_C5A1I6 Pyruvate carboxylase subunit B (PycB) n=18 Tax=A... 207 4e-52 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 207 4e-52 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 207 4e-52 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 207 4e-52 UniRef50_Q7NM88 Oxaloacetate decarboxylase alpha chain n=1 Tax=G... 207 4e-52 UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q... 207 5e-52 UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria Re... 207 5e-52 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 206 7e-52 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 206 7e-52 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 206 7e-52 UniRef50_C5VE99 Pyruvate carboxylase subunit B n=3 Tax=Corynebac... 206 8e-52 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 206 9e-52 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 206 1e-51 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 206 1e-51 UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier ... 206 1e-51 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 205 2e-51 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 205 2e-51 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 205 2e-51 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 204 3e-51 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 204 4e-51 UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax... 204 5e-51 UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillu... 204 5e-51 UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C... 203 7e-51 UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 203 7e-51 UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacill... 203 9e-51 UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular... 202 1e-50 UniRef50_D1B6M4 Pyruvate carboxylase n=2 Tax=Synergistaceae RepI... 202 2e-50 UniRef50_C0QLF7 Pcb n=1 Tax=Desulfobacterium autotrophicum HRM2 ... 201 4e-50 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 201 5e-50 UniRef50_B2A6U5 Conserved carboxylase region n=10 Tax=Bacteria R... 201 5e-50 UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenom... 200 5e-50 UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutar... 200 6e-50 UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostri... 200 8e-50 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 199 8e-50 UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria Re... 199 9e-50 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 199 1e-49 UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides... 199 1e-49 UniRef50_P13187 Oxaloacetate decarboxylase alpha chain n=404 Tax... 199 1e-49 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 199 1e-49 UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria Re... 199 2e-49 UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Ta... 199 2e-49 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 199 2e-49 UniRef50_C1DTS7 Pyruvate carboxylase subunit B (Pyruvic carboxyl... 198 2e-49 UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legione... 197 4e-49 UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 197 4e-49 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 197 5e-49 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 197 5e-49 UniRef50_C0X8H4 Pyruvate carboxylase n=24 Tax=Bacilli RepID=C0X8... 197 6e-49 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 196 8e-49 UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legione... 196 8e-49 UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transf... 195 2e-48 UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO 195 3e-48 UniRef50_B7GA98 Precursor of carboxylase pyruvate carboxylase n=... 194 3e-48 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 194 3e-48 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 194 3e-48 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 194 3e-48 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 194 3e-48 UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geob... 194 4e-48 UniRef50_Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit... 194 4e-48 UniRef50_P32327 Pyruvate carboxylase 2 n=326 Tax=cellular organi... 193 7e-48 UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga le... 193 7e-48 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 193 9e-48 UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 193 1e-47 UniRef50_UPI0001C37344 hypothetical protein RflaF_17007 n=1 Tax=... 192 1e-47 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 192 1e-47 UniRef50_C7MMV3 Acetyl-CoA carboxylase, biotin carboxyl carrier ... 192 1e-47 UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostri... 192 1e-47 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 192 2e-47 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 192 2e-47 UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synech... 192 2e-47 UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 191 2e-47 UniRef50_B1ZXN8 Pyruvate carboxylase n=5 Tax=Bacteria RepID=B1ZX... 191 2e-47 UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacter... 191 3e-47 UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Ta... 191 4e-47 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 191 4e-47 UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria Rep... 190 4e-47 UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 190 5e-47 UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferrop... 190 5e-47 UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus... 190 6e-47 UniRef50_B0TK18 Oxaloacetate decarboxylase alpha subunit n=37 Ta... 190 6e-47 UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 T... 190 7e-47 UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacte... 190 8e-47 UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... 189 1e-46 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 189 1e-46 UniRef50_C8P007 Oxaloacetate decarboxylase, alpha subunit n=1 Ta... 189 2e-46 UniRef50_A6UE85 Pyruvate carboxylase n=111 Tax=Bacteria RepID=A6... 189 2e-46 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 188 2e-46 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 188 2e-46 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 188 2e-46 UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 188 3e-46 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 188 3e-46 UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepI... 187 4e-46 UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 187 4e-46 UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryante... 187 5e-46 UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 187 7e-46 UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter l... 187 7e-46 UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular... 187 7e-46 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 186 9e-46 UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellul... 186 1e-45 UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Ba... 186 1e-45 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 186 1e-45 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 186 1e-45 UniRef50_B2UP73 Methylmalonyl-CoA carboxytransferase n=4 Tax=Ver... 186 1e-45 UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria... 185 2e-45 UniRef50_C5T2M7 Pyruvate carboxyltransferase n=1 Tax=Acidovorax ... 185 2e-45 UniRef50_Q07TZ1 Pyruvate carboxylase n=41 Tax=Bacteria RepID=Q07... 185 2e-45 UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteri... 185 3e-45 UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepI... 184 3e-45 UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular ... 184 3e-45 UniRef50_D2R6U4 Pyruvate carboxylase n=6 Tax=cellular organisms ... 184 4e-45 UniRef50_B2V325 Pyruvate carboxylase n=9 Tax=Clostridiales RepID... 184 4e-45 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 184 4e-45 UniRef50_C1D9E0 Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular... 184 5e-45 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 184 5e-45 UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase ... 183 7e-45 UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=... 183 7e-45 UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax... 183 8e-45 UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteri... 183 9e-45 UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 183 1e-44 UniRef50_B8LCZ8 Predicted protein n=3 Tax=Eukaryota RepID=B8LCZ8... 182 1e-44 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 182 1e-44 UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 182 1e-44 UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus... 182 1e-44 UniRef50_A7LNE9 Pyruvate carboxylase n=5 Tax=cellular organisms ... 182 1e-44 UniRef50_A4TE53 Pyruvate carboxylase n=40 Tax=Actinobacteria (cl... 182 2e-44 UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 182 2e-44 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 182 2e-44 UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria Re... 181 4e-44 UniRef50_B6QTB6 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyas... 181 4e-44 UniRef50_Q49WN9 Pyruvate carboxylase n=48 Tax=Bacteria RepID=Q49... 181 4e-44 UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcu... 180 4e-44 UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular orga... 180 4e-44 UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus... 180 4e-44 UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobac... 180 5e-44 UniRef50_C5EHC6 Pyruvate carboxylase subunit B n=2 Tax=Clostridi... 180 6e-44 UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia... 180 6e-44 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 180 7e-44 UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma l... 180 7e-44 UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospi... 180 8e-44 UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 180 8e-44 UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma pr... 180 8e-44 UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 180 9e-44 UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkhold... 179 1e-43 UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicr... 179 1e-43 UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacte... 179 1e-43 UniRef50_Q039M6 Pyruvate carboxylase n=9 Tax=Lactobacillaceae Re... 179 2e-43 UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria Rep... 179 2e-43 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 179 2e-43 UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira Re... 179 2e-43 UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 179 2e-43 Sequences not found previously or not previously below threshold: >UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD Length = 333 Score = 290 bits (742), Expect = 6e-77, Method: Composition-based stats. Identities = 145/334 (43%), Positives = 206/334 (61%), Gaps = 2/334 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D+TLRDG HA HQ++ E + +A+ +D V +IE HG+GL GS+ YGF A Sbjct: 2 KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFGHGNGLGGSALQYGFAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D E++EA A VVK+A ++ ++LPG+GT H+L A + GA+ R+ T TE D++ QHI Sbjct: 62 ATDREYMEAVAPVVKNADLSIIILPGVGTRHELHLAKEFGAKYARMCTQITEVDIAEQHI 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A++LGM + L + + ++ + ++ E YGA IY++D GG +R A Sbjct: 122 KMAKQLGMIPIAVLPCAGIIPVKDTVRYTQMAESYGAEVIYLLDGGGYQLPEQTYERIAA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 +K + + G H H+NL L VANS AAVE G + ID L G GAGAGN P E+F A Sbjct: 182 MKKAV--DVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFGAGAGNCPTEIFAAVM 239 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 D++ G DLY MD A+ +RPL R + VD + + LGYAG YSSFL + A ARYG Sbjct: 240 DRMEIDCGIDLYKTMDIAEQYLRPLMPRAMEVDNDRIMLGYAGCYSSFLLFAQRAGARYG 299 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + DI+ E+G+R+ GQED+ +DVA L K Sbjct: 300 VDPRDIIKEIGRRQCTEGQEDICIDVAYALAQKK 333 >UniRef50_C1B8I0 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacteria RepID=HOA2_RHOOB Length = 347 Score = 289 bits (741), Expect = 7e-77, Method: Composition-based stats. Identities = 167/337 (49%), Positives = 222/337 (65%), Gaps = 5/337 (1%) Query: 1 MNG---KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSF 57 MN KK+ I D TLRDGM ++ HQ++ +NV IA+ LD A V +IEVAHG GL SS Sbjct: 1 MNTPAQKKITIVDTTLRDGMSSVSHQFTPQNVADIARGLDRAGVGTIEVAHGIGLGASSI 60 Query: 58 NYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD 117 YGF A +D +++ AA D V++A IA L +PGI T+ +L+ A AG + VRVA HCTEAD Sbjct: 61 QYGFAAATDPDYVRAAVDAVENADIAALYVPGIATLAELQKAIDAGIKTVRVAVHCTEAD 120 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 Q +++A+E G+ + FLMMSH PE LA+QA ++ YGA +YVVDS GAM Sbjct: 121 CGQQPVEWAKEQGLTVMTFLMMSHKLDPEPLAEQAAKLDSYGADVVYVVDSAGAMVPRHA 180 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 DR AL+ + + G HAH+NL +G+AN++ A E G ID SL G+GA AGNA E Sbjct: 181 GDRVAALRQAISAD--IGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTE 238 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 V AA ++ GW G DL+ L+D A+ +V PL P VD L LGYAGVYS+F + Sbjct: 239 VLAAAFERAGWDTGVDLFPLIDTAEHIVAPLMKEPQIVDETALILGYAGVYSTFFHPTKR 298 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 AA ++G+ A DIL+ELG+R ++GGQEDMI+DVA +L Sbjct: 299 AAKKFGVPARDILMELGRRGVIGGQEDMIIDVASELA 335 >UniRef50_A4IT42 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteria RepID=HOA_GEOTN Length = 342 Score = 287 bits (735), Expect = 4e-76, Method: Composition-based stats. Identities = 184/338 (54%), Positives = 246/338 (72%), Gaps = 3/338 (0%) Query: 1 MNGKK-LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ ++ ++I++V LRDG HAI HQY++E V +A+ALD+A V IEV+HGDGL GSS Y Sbjct: 1 MSSERDIWITEVALRDGSHAINHQYTVEQVVSVAQALDEANVPYIEVSHGDGLAGSSLQY 60 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 G ++E IEAA V K AKIA LLLPGIGTI +L A + G ++VR+ATH TEAD+S Sbjct: 61 GLSRTDEMELIEAAVSVCKKAKIAVLLLPGIGTIRELDAAAKRGVKMVRIATHVTEADIS 120 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 AQHI A+ELG++ VGFLMMSHM + E L +QAKLME YGA +YVVDS GA+ ++ + Sbjct: 121 AQHITRAKELGLEAVGFLMMSHMASTEKLVEQAKLMESYGADVVYVVDSAGALLPHEVTE 180 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R RALK L + G H H+NLSL +AN++AA++EG RID S+ +GAGAGN EV Sbjct: 181 RIRALKQSLG--IEIGFHGHNNLSLAMANTLAAIQEGATRIDGSVRCLGAGAGNTQTEVL 238 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 +A D++G + G DLY +MD A+++V P+ P + R++L LGYAGVYSSF H E AA Sbjct: 239 VAVLDRIGLKTGVDLYKMMDLAEEIVAPILQVPQEITRDSLILGYAGVYSSFRLHAERAA 298 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 R+G+ + DILVELGKR++VGGQEDMI+D+A ++ + K Sbjct: 299 KRFGVDSRDILVELGKRKVVGGQEDMIIDIAAEIASKK 336 >UniRef50_Q5YV93 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocardia farcinica RepID=HOA2_NOCFA Length = 346 Score = 284 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 163/332 (49%), Positives = 218/332 (65%), Gaps = 2/332 (0%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + + D TLRDGM ++ H+++ +V IA LD A V +IEVAHG GL SS YGF Sbjct: 5 TRTVTLVDTTLRDGMSSVSHRFTPNDVAAIAAGLDRAGVRTIEVAHGIGLGASSIQYGFA 64 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 A +D E++ AA D V HA IA L +PGI T+ +L+ A +AG R VRVA HCTEAD + Q Sbjct: 65 AATDPEYVRAAVDAVDHADIAVLYVPGIATLAELRAAVEAGIRTVRVAVHCTEADCAQQP 124 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 +++A++ G+ + FLMMSH PE LA+QA +E YGA +YVVDS GAM DR Sbjct: 125 VEWAKDHGLTVMTFLMMSHKLDPEPLAEQAVKLESYGADVVYVVDSAGAMVPRHAGDRVA 184 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 AL+ + + G HAH+NL +G+AN++ A E G ID SL G+GA AGNA EV AA Sbjct: 185 ALRRAIS--AEIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNAQTEVLAAA 242 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 ++ GW G +L+ L+D A+ +V PL P VD L LGYAGVYS+F + AAA++ Sbjct: 243 FERAGWHTGVELFPLIDTAEQVVAPLMTEPQIVDETALVLGYAGVYSTFFHPTKRAAAKF 302 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 G+ DIL+ELG+R ++GGQEDMIVDVA +L Sbjct: 303 GVPTRDILLELGRRGVIGGQEDMIVDVASELA 334 >UniRef50_A8LAA1 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bacteria RepID=HOA1_FRASN Length = 377 Score = 274 bits (702), Expect = 2e-72, Method: Composition-based stats. Identities = 228/329 (69%), Positives = 258/329 (78%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 LY+ DVTLRDGMHA+RH+YS+E R IA ALD + V +IEVAHGDGL GSS NYG GAH+ Sbjct: 27 LYVQDVTLRDGMHAVRHRYSVETARTIATALDASGVRAIEVAHGDGLAGSSINYGIGAHT 86 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D EWIEA V +A +LLLPGIGT+ DL+ A G R VRVATHCTEAD+SAQHI Sbjct: 87 DWEWIEAVTASVTNAIPTSLLLPGIGTVRDLRQAHALGIRSVRVATHCTEADISAQHISA 146 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 AR+LGMD GFLMMSHM P LA+QA+LME YGA C+YV DSGG + M D+RDRFRA Sbjct: 147 ARDLGMDVAGFLMMSHMAAPAELARQARLMESYGAHCVYVTDSGGRLTMDDVRDRFRAYS 206 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L P T+TG+HAHHNL LGVAN++ AVE G R+DASLAG GAGAGN PLE FIA AD Sbjct: 207 DVLDPATETGIHAHHNLGLGVANTVVAVENGATRVDASLAGQGAGAGNCPLEAFIAVADL 266 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 +GW+HG +L+ LMD ADD+VRPLQDRPVRVDRETL LGYAGVYSSFLRH E AA RYGL Sbjct: 267 MGWKHGCELFGLMDTADDVVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAAATRYGLD 326 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLR 334 IL E+G+R MVGGQEDMIVDVALDL Sbjct: 327 TRTILAEVGRRGMVGGQEDMIVDVALDLV 355 >UniRef50_A1K893 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Proteobacteria RepID=HOA3_AZOSB Length = 346 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 192/333 (57%), Positives = 245/333 (73%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ + D+TLRDGMH RH +LE ++ IA+ LD A + IEV HGDGL GSS NYGF AH Sbjct: 7 RITVHDMTLRDGMHPKRHLMTLEQMKTIAQGLDQAGIPLIEVTHGDGLGGSSVNYGFPAH 66 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 +D E++ A ++K AK++ LLLPGIGT+ LK A + G +RVATHCTEADVS QHI+ Sbjct: 67 TDEEYLGAVIPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRVATHCTEADVSEQHIR 126 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 YAR+LGMDTVGFLMM+HM +PE L +QAKLME YGA CIYV DS G + ++ R A+ Sbjct: 127 YARKLGMDTVGFLMMAHMNSPEGLVQQAKLMESYGANCIYVTDSAGHLLPDTVKARIGAV 186 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 +A LKPET+ G H HHNL++GVANSIAA+E G RIDA+ AG+GAGAGN P+EV IA D Sbjct: 187 RAALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVLIAVCD 246 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGL 304 +G + G D++ + D A+DLV P+ D P+R+DR+ L LGYAGVY SFL + A +YG+ Sbjct: 247 LMGIETGVDVFKIQDVAEDLVVPIMDFPIRIDRDALTLGYAGVYGSFLLFAKRAEKKYGV 306 Query: 305 SAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 A +ILVE+G+R MVGGQEDMI D A+ L K Sbjct: 307 PAREILVEMGRRGMVGGQEDMIEDTAITLAKAK 339 >UniRef50_A3Q4B9 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bacteria RepID=HOA1_MYCSJ Length = 363 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 168/331 (50%), Positives = 220/331 (66%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ++D +LRDG H RHQ++ + V I ALD A V IEV HGDGL GSSFNYGF Sbjct: 13 VRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTP 72 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 + E I+ AA+ K AKIA L+LPG+GT D+K A G + R+ATHCTEADVS QH Sbjct: 73 EQELIKLAAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGL 132 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 ARELG++TVGFLMMSH PE LA+QA++M G C+YVVDS GA+ + +RDR AL Sbjct: 133 ARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALV 192 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 AEL + Q G H H NL LGVANS+ AV G +ID S GAGAGNAP+E I DK Sbjct: 193 AELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDK 252 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 +G + G D + + DAA+++V P +DR L +GY+GVYSSFL+H + RYG+ Sbjct: 253 IGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVP 312 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A +L G+R+++GGQED ++D+AL+++ Sbjct: 313 AHQLLHRAGQRKLIGGQEDQLIDIALEIKRE 343 >UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS Length = 352 Score = 268 bits (685), Expect = 2e-70, Method: Composition-based stats. Identities = 97/335 (28%), Positives = 172/335 (51%), Gaps = 3/335 (0%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ I D TLRDG +++ ++ + I L+ + + IEV HG G S+ YG Sbjct: 2 SKKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVGHGLGFNASNSGYGKS 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 SD E++ AA + + + +PGI + DL+ A + G +RV T T+ S + Sbjct: 62 TQSDEEYMIAAKESLSKSMYGMFCIPGIAKLSDLELAKKHGMGFIRVGTDVTKVHQSEKF 121 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I+ A+ LG M S++ P+ A K E +G +Y+VDS G M SD+ + + Sbjct: 122 IKKAKNLGFFVASNFMKSYVMPPDKFASIVKQSEEFGTDMVYIVDSAGGMFSSDLLEYYN 181 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +++ E G H H NL + ++NS+ A + G + ID+SL G+G +GNA EV + A Sbjct: 182 SIRN--VSEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGIGRSSGNACTEVLVMA 239 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 K G++ D ++L +A + V PL + ++ + + GYA +SS++ H ++++ Sbjct: 240 LKKKGFKIDVDFHSLFEAGQECVYPLINNSNKLPLD-IVSGYADFHSSYMHHIMKYSSKF 298 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + + +++E K + E + +A L+ + Sbjct: 299 KVDPLLLIIEYSKINKIDIDEKKLEQIAKKLKRKQ 333 >UniRef50_B6BTH8 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta proteobacterium KB13 RepID=B6BTH8_9PROT Length = 337 Score = 267 bits (682), Expect = 4e-70, Method: Composition-based stats. Identities = 132/337 (39%), Positives = 193/337 (57%), Gaps = 3/337 (0%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ ISD TLRDG HAI+H++S +++ K D AR+ +EV HG+G+ SS G Sbjct: 1 MESKKILISDPTLRDGSHAIKHKFSKDDISNYCKLADKARIPIVEVGHGNGIGASSLQLG 60 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIH-DLKNAWQAGARVVRVATHCTEADVS 119 SD + + A +K +K+ ++PG TI D+ A G V R+ATHCTE+D+S Sbjct: 61 ESLLSDFDMLSTARKNLKKSKLGVHVIPGFATIDKDILPAVDVGVDVFRIATHCTESDLS 120 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 +HI + R+ ++ G LMM+HM E L QAK +E YGA + +DS G+ + I++ Sbjct: 121 ERHISFLRKKNLEVWGCLMMAHMVDTETLIDQAKKIENYGADGVIFMDSAGSFIPNQIKE 180 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVF 239 R L +EL G H H+NL+L VANS+ A++ G +DA AG GAGAGN LEV Sbjct: 181 RVEGLVSEL--NIMVGFHGHNNLNLAVANSLEAIQSGATLVDACSAGFGAGAGNTQLEVL 238 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAA 299 I K + D L+D A+ ++ V +++ GY GV+S FL A Sbjct: 239 IPVLLKQNFDTNIDFNGLLDLAEFVISKFGKSTSSVHIDSMISGYYGVFSGFLVPVRRVA 298 Query: 300 ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 Y +S +DI ELG+R ++ GQED+I++VA +R+ Sbjct: 299 LEYKISPIDIFKELGRRNIIAGQEDLIIEVANSIRDK 335 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 78/365 (21%), Positives = 136/365 (37%), Gaps = 48/365 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + + +IAK L+ VD +E QG Sbjct: 3 KINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQG---------- 52 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVV----RVATHCTEADV-- 118 D E + A A+ +K+A + L D+ AW A V + + + Sbjct: 53 -DFEGVRAIANTIKNASVTGL---ARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTY 108 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + YA + + + L K + + GAT I + Sbjct: 109 KLKKTPEQVIQTAVDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLP 168 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + D F+ ++ ++ + H H +L + VAN+IAAVE G +++ ++ Sbjct: 169 DTVGYTTPQEYGDLFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTI 228 Query: 225 AGMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVRP----LQDRPVRVD 276 G+G AGNA LE A + K + L + +D + + + V Sbjct: 229 NGIGERAGNASLEEIAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVG 288 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 R A L++ T G+ + +++ LGK +D I + + Sbjct: 289 RNAFAHESGIHQDGVLKNASTYEIITPELVGIQSNNLV--LGKHSGRHAFKDKIEQLGYE 346 Query: 333 LRNNK 337 L +K Sbjct: 347 LAEDK 351 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 76/358 (21%), Positives = 131/358 (36%), Gaps = 43/358 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDG + QIAK LD VD IE +G Sbjct: 2 RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------- 116 + E ++ A++ +AKI L D+ A +A +V V ++ Sbjct: 53 --EFEAVKEIANLGLNAKICGL---ARVVKKDIDQAIKADVDIVHVFIPTSKIQVEHTIK 107 Query: 117 -------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +S ++Y + G++ + M + T + L + K +E G I V D+ Sbjct: 108 KTPDEIVQLSVDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G D + LK L +H H++ L AN+ AAV G D + ++ G+G Sbjct: 168 GIATPFRFYDMIKKLKEHL--NVPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGE 225 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALGYA 285 AGNAPLE +A G++ + L++ + + R + V + Sbjct: 226 RAGNAPLEEVVALLYAEGFKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESG 285 Query: 286 GVYSSFLRHCETA------AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L+ T G + +GK + ++ D + + K Sbjct: 286 IHAHGVLKDARTFEPGIITPEMVGHKRRIV---VGKHAGRHQIKKILEDAGYVVDDEK 340 >UniRef50_Q4F8H9 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseudomonas pseudoalcaligenes RepID=HOA1_PSEPS Length = 347 Score = 261 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 169/340 (49%), Positives = 220/340 (64%), Gaps = 3/340 (0%) Query: 1 MN--GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 MN GK + + D++L MH + +LE + + LD R+ IE+ DGL G S N Sbjct: 1 MNLQGKNVTLYDMSLLXFMHPNPYHITLEQMIAVPTVLDAPRIPLIEITLRDGLGGRSIN 60 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 Y F AH D E++ A +K AK++ LLLPGIGT+ L A G + VATHCTEADV Sbjct: 61 YVFPAHIDEEYLRAVIPRLKQAKVSALLLPGIGTVDHLNMALDCGVSTILVATHCTEADV 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKL-MEGYGATCIYVVDSGGAMNMSDI 177 S HI +R LG DTVGFLMM+HM A A+L ++ YGA CIY DS G M ++ Sbjct: 121 SEHHIGMSRMLGADTVGFLMMAHMIRRGKSAGAARLDVKCYGANCIYCTDSAGYMLPDEV 180 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 ++ L+AEL P T+ G H HHN+ + +ANS+A G RID S+AG+GAGAGN PLE Sbjct: 181 SEKIGLLRAELNPATEIGFHGHHNMGMAIANSLAGHRGGASRIDGSVAGLGAGAGNTPLE 240 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 VF+A ++G + G DLY +MD A+DLV P+ D+P+RVDR+ L LGYAGVYSSFL + Sbjct: 241 VFVAVCKRMGVETGIDLYKIMDVAEDLVVPMMDQPIRVDRDALTLGYAGVYSSFLLFAQR 300 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 A +YG+ A DILVELG+R VGGQEDMI D+ALD+ + Sbjct: 301 AEKKYGVPARDILVELGRRGTVGGQEDMIEDLALDMSRAR 340 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 77/365 (21%), Positives = 138/365 (37%), Gaps = 42/365 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 ++ I D TLRDG + + E ++A+ L+ D IE G Sbjct: 3 QANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPG------- 55 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEADV-- 118 D E + A A + + + +L I A A + + + + Sbjct: 56 ----DFEAVNAIAKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEY 111 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + ++ ARE D + + + LA+ + GAT I + Sbjct: 112 KLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIP 171 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + FR L A+ + H H++L L VANS+AA++ G +++ ++ Sbjct: 172 DTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTV 231 Query: 225 AGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVD 276 G+G AGNA +E + A D G + G D ++ ++ + P+Q V Sbjct: 232 NGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVG 291 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 + L+H ET A G SA + LGK + + D+ ++ Sbjct: 292 ANAFSHESGIHQDGVLKHRETYEIMSAESVGWSANRL--SLGKLSGRNAFKTKLADLGIE 349 Query: 333 LRNNK 337 L + + Sbjct: 350 LESEE 354 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 66/363 (18%), Positives = 128/363 (35%), Gaps = 42/363 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + + QIA+ L VD IE G Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW-QAGARVVRVATHCTEADV---- 118 D E + A VK +A L I +A A + + ++ + Sbjct: 53 --DKEAVSLIAREVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKL 110 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++ A++ D + + + L + + GAT I + D+ Sbjct: 111 KMDRETVVERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDT 170 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + + ++ +H H +L L VANS+AA++ G +++ ++ G Sbjct: 171 VGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTING 230 Query: 227 MGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRE 278 +G AGN LE + A L + G + + + P+Q V + Sbjct: 231 IGERAGNCSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKN 290 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 + L+ T G+ ++ LGK ++ ++++ +L Sbjct: 291 AFSHESGIHQDGVLKERTTYEIMNPRLVGIPESRLV--LGKHSGRHALKERLLELGYELT 348 Query: 335 NNK 337 + Sbjct: 349 EEQ 351 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 81/367 (22%), Positives = 132/367 (35%), Gaps = 48/367 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG + +L ++A AL D VD IE G Sbjct: 15 TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPG-------- 66 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSA 120 D E + A ++ A I L D+ AW+A A R+ + + Sbjct: 67 ---DFESVRQIATTIRGATICGL---ARCAEKDIDRAWEALKTAPQARIHVFLATSAIHR 120 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + ++ A D + T + L + + GAT I Sbjct: 121 EFKLRMTPDEIVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTIN 180 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 V D+ G +I DRF+ L+ + + H H +L + VANS+AAV+ G +I+ Sbjct: 181 VPDTVGYTTPGEIYDRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIEC 240 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVRP----LQDRPVR 274 ++ G+G AGNA LE + A Q + L+ + + + +Q Sbjct: 241 TINGIGERAGNAALEELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAI 300 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V R A L+ T G + D++ LGK D + Sbjct: 301 VGRNAFAHESGIHQDGMLKERTTYEIMSPEEVGFTKTDLV--LGKHSGRAALADRAKQLG 358 Query: 331 LDLRNNK 337 + L + Sbjct: 359 MTLTGEQ 365 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 71/362 (19%), Positives = 123/362 (33%), Gaps = 39/362 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + I D TLRDG + SL+ +IA+AL VD IE Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPM--------- 55 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEAD----- 117 + E + A VK IA L I A + A + V T ++ Sbjct: 56 --EFEAVRRIATEVKGPIIAALARTHTLDIDQAAKALEKAEKPRIHVFTSASKVHLQYML 113 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ + ++YAR D E + + ++ GAT I + D+ Sbjct: 114 RKTEEEVLEMADRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPDT 173 Query: 169 GGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + R ++ E+ + H H +L + AN++A VE G +I+ ++ G Sbjct: 174 TGYGTPQEYGALIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTING 233 Query: 227 MGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGN LE + A + + + + R P+ V Sbjct: 234 IGERAGNCALEEVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDN 293 Query: 279 TLALGYAGVYSSFLRHCETAAARYG--LSAVDILVELGKRRMVGGQEDMIVDVALD-LRN 335 A ++H T + ++ LGK + + D+ L Sbjct: 294 AFAHESGIHQDGVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSE 353 Query: 336 NK 337 + Sbjct: 354 EE 355 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 73/364 (20%), Positives = 130/364 (35%), Gaps = 44/364 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG +++ IAK L VD IE G Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW-QAGARVVRVATHCTEA------ 116 D E ++ A V+ I I I + A A + + ++ Sbjct: 53 --DFEAVQRIAREVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQL 110 Query: 117 --------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ + +A++ + M + T E L + + GAT I + D+ Sbjct: 111 GKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDT 170 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + + ++ ++ + +H H++L + VANSI A G +I+ ++ G Sbjct: 171 VGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTING 230 Query: 227 MGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE + D LG++ G DL L + + R P+ V + Sbjct: 231 VGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKN 290 Query: 279 TLALGYAGVYSSFLRHCETAAARYGLSAV-----DILVELGKRRMVGGQEDMIVDVALDL 333 L+ T + D ++ LGK + + DL Sbjct: 291 VFTHESGIHQDGVLKERSTYEV---IDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDL 347 Query: 334 RNNK 337 + Sbjct: 348 DEER 351 >UniRef50_B5KC29 AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB Length = 830 Score = 256 bits (655), Expect = 6e-67, Method: Composition-based stats. Identities = 89/335 (26%), Positives = 155/335 (46%), Gaps = 8/335 (2%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 I D TLRDG + ++L+ R + L ++ IEV HG GL + +D Sbjct: 2 KILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGHGIGLGATEKGISPAVETD 61 Query: 67 LEWIEAAADVVK-----HAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 ++++AAA V+ AK +PGI ++ + A +R+ + +++ Sbjct: 62 QDYMKAAALAVEESGSQKAKWGMFCIPGIAELNHIDLAHDHNMGFIRIGVTVEDINLARS 121 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++ +++LG+ M S+ ++P+ + +GA Y+VDS G M +D+ D F Sbjct: 122 FVEKSKKLGLYVCVNFMKSYTSSPQEFSAAVAQAASFGADIAYLVDSAGTMVPADVEDYF 181 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIA 241 R ++ G H H+NL L N+ A EG +D S+ GMG GN E F+A Sbjct: 182 RTVRRNSI--LPLGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTEHFLA 239 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAAR 301 K G H D LMD ++ VRP + + +D +A G AG +SS++ + + Sbjct: 240 LLGKQGIAHNLDPIGLMDLSEKYVRP-KLTDIGIDSVDVACGLAGFHSSYMSVIKKYSLE 298 Query: 302 YGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 Y + +++EL K E ++ + A ++ Sbjct: 299 YDIDPRRLIIELCKETRDAAPEKLVKEKAEIIKKQ 333 >UniRef50_A4F0P9 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseobacter sp. SK209-2-6 RepID=A4F0P9_9RHOB Length = 352 Score = 256 bits (654), Expect = 8e-67, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 165/330 (50%), Gaps = 2/330 (0%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + I Q++ + I ALD A IEV HG G+ S A SD Sbjct: 8 KVLDCTLRDGSYVIDFQFTSADTESIGGALDQAGFPYIEVGHGVGMGASETGNNVAAASD 67 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYA 126 +++ AAA V K +PG+ + ++ A G +RV T +AD + I+ A Sbjct: 68 ADYMAAAAKSVTSGKWGMFCIPGVANLDHVRLAADHGIGFIRVGTDVAQADSAIPFIELA 127 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 R+LG++ M S++ PE A YGA +Y+VDS G M ++R +A K+ Sbjct: 128 RKLGIEVFANFMKSYVLEPEAFGALAARSYDYGAEMVYLVDSAGGMLPHEVRAYLQAAKS 187 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 PE G H H NL L VANS+ ++EEG +D SL G G +GN E+F+ A + Sbjct: 188 A-APELPLGFHGHDNLGLAVANSLVSLEEGAAMVDTSLQGFGRSSGNTATELFLGATIRS 246 Query: 247 GWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSA 306 G++ + +MD + LVRPL +R + +A G A +SS++ A + + Sbjct: 247 GYEAFAEPIEVMDLGETLVRPLIERRGFCSLD-IAAGQALFHSSYMPKILRVAKQNRVDP 305 Query: 307 VDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +++EL K V ++++ +A +L N Sbjct: 306 RRLIIELCKHDKVNAPDELLSRLAAELSEN 335 >UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA Length = 491 Score = 256 bits (653), Expect = 1e-66, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 128/355 (36%), Gaps = 42/355 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + + +IAK LD+ VD IE +G Sbjct: 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKG----------- 51 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E I+ +A+I + + D+ A + V + + + Sbjct: 52 EREGIKLITKEGLNAEICSFV---RALPVDIDAALECDVDSVHLVVPTSPIHMKYKLRKT 108 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + ++YA+E G+ + + L K E GA + V D+ G Sbjct: 109 EDEVLETALKAVEYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGV 168 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + ++ F+ + + +H H++ + AN+ +AV G + ++ G+G A Sbjct: 169 LTPQKSQELFKKITENV--NLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERA 226 Query: 232 GNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 GNA LE +AA G+ + L + + + R P+ V A Sbjct: 227 GNASLEEVVAALKILYGYDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGI 286 Query: 287 VYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 +++ ET G I LGK + + + +++ + + Sbjct: 287 HVDGLIKNTETYEPIKPEMVGNRRRII---LGKHSGRKALKYKLDLMGINVSDEQ 338 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats. Identities = 81/363 (22%), Positives = 134/363 (36%), Gaps = 44/363 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E IA LDD VD IE G Sbjct: 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDG---------- 60 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH-- 122 D E + A K+A I L G I A + A+ R+ T + + V ++ Sbjct: 61 -DFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIR-PAKRGRIHTFLSTSPVHMKYKL 118 Query: 123 --------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + AR D T + L + + GA+ I + D+ Sbjct: 119 QMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDT 178 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + D F+ ++ + + +H H++L + VANS+A V G +I+ ++ G Sbjct: 179 VGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTING 238 Query: 227 MGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE + A KL + + D L A+ + P+Q V R Sbjct: 239 IGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRN 298 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A L++ +T G+ ++ +GK + ++ L Sbjct: 299 AFAHESGIHQDGMLKNAQTYEIMLPETVGVKQTSLV--MGKHSGRHAFIHKLEEMGHKLS 356 Query: 335 NNK 337 +N+ Sbjct: 357 SNQ 359 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 253 bits (647), Expect = 5e-66, Method: Composition-based stats. Identities = 70/352 (19%), Positives = 122/352 (34%), Gaps = 41/352 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I D TLRDG ++ E IA+ L V SIE QG Sbjct: 17 PKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQG-------- 68 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV---- 118 + E ++A A +I L D+ A A + V ++ + Sbjct: 69 ---EFEAVKAIAREGLGPEIVAL---ARANKRDIDKALDADVDAIHVFIAASDIHLKYKL 122 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++YA+ G+ L + + GA + + D+ Sbjct: 123 RMTREEALRRAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDT 182 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G M + ++ + + K +H H++ L VANSIA +E G + ++ G+G Sbjct: 183 VGVMTPTRMKYLIKFILPAAKGRI-VSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIG 241 Query: 229 AGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALG 283 AGNA LE +AA L + G + L + + + + P+ V + Sbjct: 242 ERAGNAALEEVVAALEFLLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHE 301 Query: 284 YAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 + + T G + LGK G E + + Sbjct: 302 SGIHVHGVINNPFTYEPIQPEMVGQRRRIV---LGKHSGRHGVEYALKTLGY 350 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 253 bits (647), Expect = 6e-66, Method: Composition-based stats. Identities = 76/361 (21%), Positives = 126/361 (34%), Gaps = 43/361 (11%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN + + I D TLRDG ++E IA+ LD VD+IE G Sbjct: 10 MNLPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPG----- 64 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 ++ I ++ A I L D+ A G + + Sbjct: 65 ------EMNSIRRIVELGLEANICGL---ARVLREDIDAAIDCGVDYIHTFIGTSPLHRE 115 Query: 120 AQH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + ++YA E G+ + T + L + + E GA I V Sbjct: 116 YKLKMSPDEIIDRAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINV 175 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G M + LK EL+ +H H++ L VANS+AAVE G ++ A++ Sbjct: 176 PDTVGVMIPRAMNHLVSRLKEELR--VPISVHCHNDFGLAVANSLAAVEAGASQVHATVN 233 Query: 226 GMGAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETL 280 G+G AGNA LE + A + L++ ++ + + + V Sbjct: 234 GLGERAGNAALEEVVMALITRYDLPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAF 293 Query: 281 ALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A L ET G + LGK + + ++++ Sbjct: 294 AHEAGIHVHGVLEKAETYEPITPEMVGHKRRIV---LGKHTGANALRSKLQEYGIEMKEE 350 Query: 337 K 337 + Sbjct: 351 Q 351 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 253 bits (646), Expect = 7e-66, Method: Composition-based stats. Identities = 72/363 (19%), Positives = 136/363 (37%), Gaps = 42/363 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ + D TLRDG + + IAK L+ VD IE +G Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-VVRVATHCTEADV---- 118 D ++ A +K+ + L G I A + G + + ++ + Sbjct: 53 --DFLAVQEIARTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKL 110 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++YA+E + T LA+ + + GA+ I + D+ Sbjct: 111 KMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDT 170 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + + F+ +K + + H H +L + VANS++A+E G D+I+ ++ G Sbjct: 171 VGYLTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAING 230 Query: 227 MGAGAGNAPLEVFIAAADKLG----WQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE A +L+ L +D + + + V Sbjct: 231 IGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDN 290 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A FL+ T G++A ++ LGK +D + + Sbjct: 291 AFAHESGIHQDGFLKEKSTYEIISPELVGVTADALV--LGKHSGRHAFKDRLNTLGFQFD 348 Query: 335 NNK 337 +++ Sbjct: 349 SDE 351 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 72/364 (19%), Positives = 131/364 (35%), Gaps = 44/364 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG + +L +IA+ L+ VD IE +G Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-VVRVATHCTEADV---- 118 D + ++A A V++ + L I A + GA + V + + Sbjct: 53 --DFQAVQAIAQTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKL 110 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++YA++ + + LA + + GA I + D+ Sbjct: 111 RMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDT 170 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + D F LK ++ + H H +L + VANS+AA+E G +I+ ++ G Sbjct: 171 VGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTING 230 Query: 227 MGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRE 278 +G AGNA +E A + +L + + + + + V + Sbjct: 231 IGERAGNAAIEEVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKN 290 Query: 279 TLALGYAGVYSSFLRHCETAAARYGLSAVDILVE-----LGKRRMVGGQEDMIVDVALDL 333 A L+ T +S + V+ LGK I ++ L Sbjct: 291 AFAHESGIHQDGVLKEKTTYEI---ISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSL 347 Query: 334 RNNK 337 + Sbjct: 348 TEEE 351 >UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR Length = 354 Score = 251 bits (640), Expect = 3e-65, Method: Composition-based stats. Identities = 101/336 (30%), Positives = 168/336 (50%), Gaps = 4/336 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I + TLRDG + I Q+S +N IA ALD+A + IEV HG GL + G Sbjct: 1 MNNPK--ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHGVGLGATEKKIG 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 SD ++++AA+ V + K +PGI T+ L+ A +R+ + + S Sbjct: 59 VALESDEVYMKSAAESVTNGKWGMFAIPGIATLEHLEMAKNYDMDFIRIGSTIEDFPKSE 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + A+ GM T M S+ PE+LA+ +KL G +YVVDS G M ++++ Sbjct: 119 AFVSSAKSQGMMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSAGGMLPNEVKLY 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 A+ AE K + G H H+NL LG+ N++AA+E G ID SL G G AGN E + Sbjct: 179 VEAILAE-KSDAVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGFGRSAGNTTTEQML 237 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 ++G + D +MD ++L++P+ ++ +T+ G A +SS++ + Sbjct: 238 GCLARMGLEGNIDPIKVMDIGEELIKPMIEKRGLTSIDTV-SGMALFHSSYMPVIHEMST 296 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +Y + ++ + +V + +++ A + Sbjct: 297 KYRVDPRQLISAVCSEDIVNAESELVEHHAKAIAEA 332 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 251 bits (640), Expect = 3e-65, Method: Composition-based stats. Identities = 79/365 (21%), Positives = 139/365 (38%), Gaps = 48/365 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + E +A+ LDD VD IE + G Sbjct: 11 RVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDG---------- 60 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSAQH 122 D E + A K++ I L + D+ +A A R+ T + + V ++ Sbjct: 61 -DFEAVHEIAKRSKNSVICGL---SRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKY 116 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + AR D + T + L + + GAT I + Sbjct: 117 KLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLP 176 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + R+ FR ++ + + + +H H++L + VANS+A V G +I+ ++ Sbjct: 177 DTVGYAVPEEYREMFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTI 236 Query: 225 AGMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVD 276 G+G AGNA LE + A KL + + + L A+ + P+Q V Sbjct: 237 NGIGERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVG 296 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 R A +++ +T G+ ++ +GK G + ++ Sbjct: 297 RNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLV--MGKHSGRAGLIHKLEELGYK 354 Query: 333 LRNNK 337 L N+ Sbjct: 355 LSRNQ 359 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 251 bits (640), Expect = 4e-65, Method: Composition-based stats. Identities = 73/362 (20%), Positives = 127/362 (35%), Gaps = 43/362 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ + D TLRDG + +L ++A+AL + VD IE +G Sbjct: 34 MTPDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKG------ 87 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E + A K + I L G A A R+ + + + Sbjct: 88 -----DFESVNEIAKNTKGSVICALARSGGVKDIAAAGEALAPAERKRIHNFISTSPLHM 142 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ AR L D T P+ L + + GAT I Sbjct: 143 KYKLRMEPETVLELITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTIN 202 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G D+ F L+ + + H H++L L VAN++A++ G +++ Sbjct: 203 IPDTVGYATPEDMEKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVEC 262 Query: 223 SLAGMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDL----VRPLQDRPVR 274 ++ G+G AGNA LE + A + + G L+ + L +Q Sbjct: 263 TINGIGERAGNAALEEIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAI 322 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V R A L++ T G + ++ +GK D + + Sbjct: 323 VGRNAFAHESGIHQDGVLKNAATYEIMTPESVGWTRSSLV--MGKHSGRAAFRDKLKVLG 380 Query: 331 LD 332 + Sbjct: 381 YE 382 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 250 bits (639), Expect = 5e-65, Method: Composition-based stats. Identities = 78/378 (20%), Positives = 128/378 (33%), Gaps = 56/378 (14%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N ++ I D TLRDG + +LE IA L VD IE F Sbjct: 4 NPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFP-----------F 52 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVS 119 + D + + A V T+ + D+K ++A A R+ T +D+ Sbjct: 53 ASPGDFKAVNKIASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIH 112 Query: 120 A----------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 + + YA+ L D + + P+ L + +L GAT I Sbjct: 113 LKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTI 172 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G S+ + + + E +H H++L L VAN + AV+ G +++ Sbjct: 173 NIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLE 232 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQ---------------HGTDLYALMDAADDLV- 265 ++ G+G AGNA LE + A + + + Sbjct: 233 CTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSN 292 Query: 266 ---RPLQDRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRM 318 +Q V A L++ T A GLS I LGK Sbjct: 293 LTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKI--SLGKLSG 350 Query: 319 VGGQEDMIVDVALDLRNN 336 + ++ DL Sbjct: 351 RSAVRARLEEMGYDLSRE 368 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 250 bits (639), Expect = 5e-65, Method: Composition-based stats. Identities = 76/365 (20%), Positives = 136/365 (37%), Gaps = 48/365 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I D TLRDG + +L+ ++A+ L+ VD +E QG Sbjct: 7 RIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQG---------- 56 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSAQ- 121 D E ++A A VK ++A L D+ AW+A A R+ T + V Q Sbjct: 57 -DFEAVQAIARAVKGVEVAGL---CRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQY 112 Query: 122 ---------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +++A + + + + P+ L + + + GAT I V Sbjct: 113 KLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVP 172 Query: 167 DSGGAMNMSDIRDRFRALKAELKPE--TQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + R + +H H++L +GVAN++AA++ G + + ++ Sbjct: 173 DTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTI 232 Query: 225 AGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVRVD 276 +G+G AGNA LE + A G L L P+ V Sbjct: 233 SGIGERAGNASLEEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVG 292 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 A L++ ET G + D++ +GK ++ + ++ Sbjct: 293 ANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLV--IGKHSGRNAVKNKLDELGYR 350 Query: 333 LRNNK 337 L + Sbjct: 351 LEEAQ 355 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 250 bits (639), Expect = 5e-65, Method: Composition-based stats. Identities = 70/361 (19%), Positives = 131/361 (36%), Gaps = 42/361 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ + D TLRDG + +IA LD VD IE +G Sbjct: 15 MQSKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEG------ 68 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE----- 115 D E +++ ++ + L D+ +++ +V ++ Sbjct: 69 -----DKESVKSISNAGLDTTVCGL---ARVLKKDIDACFESDVGLVHTFVPTSDVQRIY 120 Query: 116 ---------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 ++ + +QY ++ G+ + M + T PE L + K ++ G I V Sbjct: 121 TIKKSREEVIQLAVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVP 180 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G M S + + + + AE+ +H H++ L VANS+ AVE G ++ ++ G Sbjct: 181 DTVGVMVPSAMYRQIKGIAAEIT--IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTING 238 Query: 227 MGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLA 281 +G AGNA L + + G + L++ + + L V + + Sbjct: 239 IGERAGNADLSQTVMSLTSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFS 298 Query: 282 LGYAGVYSSFLRHCET-----AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L +T I+ LGK + + + +N Sbjct: 299 HESGIHSQGVLEKSDTFEPGIMTPEMVGHRRRIV--LGKHTGKHAVKQSLESAGIKTNDN 356 Query: 337 K 337 + Sbjct: 357 Q 357 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 249 bits (636), Expect = 9e-65, Method: Composition-based stats. Identities = 80/369 (21%), Positives = 129/369 (34%), Gaps = 46/369 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +L + D TLRDG + ++AK L VD IE QG Sbjct: 3 MTANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQG------ 56 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E + A VK KI L I A +A A R+ + + Sbjct: 57 -----DFESVSEIAAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHR 111 Query: 121 ----------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + ++ A+ D + T PE LAK + + GAT + Sbjct: 112 RFKLAKDEEEIVRIAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVN 171 Query: 165 VVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + R L + + +H H++L L V+NS+AA++ G +++ Sbjct: 172 IPDTVGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEG 231 Query: 223 SLAGMGAGAGNAPLEVFIAAADKL-----GWQHGTDLYALMDAADDLVRP----LQDRPV 273 ++ G+G AGNA LE I A + G L ++ + + R +Q Sbjct: 232 TINGIGERAGNAALEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKA 291 Query: 274 RVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVE-----LGKRRMVGGQEDMIVD 328 V A L+ ET + I E L K E+ + Sbjct: 292 VVGENAFAHAAGIHQDGILKKRETYEI---IDPKIIGWEQSELPLTKHSGRAALENRLKI 348 Query: 329 VALDLRNNK 337 + +L + Sbjct: 349 LGFELEKEE 357 >UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG Length = 340 Score = 249 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 131/331 (39%), Positives = 183/331 (55%), Gaps = 1/331 (0%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG HA+ H+ L +R+ A+A D ARV +EV HG+GL SS G A Sbjct: 2 KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVGHGNGLGASSLQVGLAA 61 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D + + ++H+++ T +LPG GT DL+ A G V RV H TEA ++ H+ Sbjct: 62 ATDDAMLSTVREALRHSRLGTFMLPGWGTSDDLRRAISHGVDVFRVGVHATEASLAEHHL 121 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + R+ G + LMMSHM +P LA+QA GYGA + ++DS G D+ R A Sbjct: 122 GFLRDAGAEAHCVLMMSHMASPGELAEQAARAVGYGAQAVGIMDSAGHFLPPDVTARIGA 181 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 + + H H+NL + VANS+AA E G ID G GAGAGN LEV + Sbjct: 182 IVEAVGT-VPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGAGNTQLEVLVPVL 240 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 ++ G+ G DLYAL+DAAD R L P ++ G AGV+S F A G Sbjct: 241 ERSGFATGIDLYALLDAADLAERELMPAPPVPASMSIVSGLAGVFSGFKHRVVELAGAAG 300 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 + ++ ELG+R+ + GQED+IVDV +L Sbjct: 301 VDPREVFFELGRRQAIAGQEDLIVDVVAELS 331 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 249 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 69/376 (18%), Positives = 125/376 (33%), Gaps = 52/376 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + I D TLRDG + + + IA+ L VD IE + Sbjct: 84 PNYVRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASK--------- 134 Query: 63 AHSDLEWIEAAADVVKHAK-----IATLLLPGIGTIHDLKNAWQ----AGARVVRVATHC 113 D E ++ A+ V + + + D++ AW+ A + Sbjct: 135 --DDFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIAT 192 Query: 114 TEAD--------------VSAQHIQYARELGM-DTVGFLMMSHMTTPENLAKQAKLMEGY 158 ++ ++ +++AR LG D + + E L + + Sbjct: 193 SDIHLKYKLKKSKEEVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKA 252 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEG 216 GAT + + D+ G S+ +KA H ++L L AN+++ G Sbjct: 253 GATTLNIPDTVGITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSG 312 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQ------HGTDLYALMDAADDLV----R 266 +++ ++ G+G AGNA LE + A G G D ++ + + Sbjct: 313 ARQVEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGM 372 Query: 267 PLQDRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSA-VDILVELGKRRMVGG 321 Q V A L+H T GL D + LGK Sbjct: 373 QTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHA 432 Query: 322 QEDMIVDVALDLRNNK 337 +D + ++ L + + Sbjct: 433 LKDRLNELGYVLDDGQ 448 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 249 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 65/374 (17%), Positives = 128/374 (34%), Gaps = 53/374 (14%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG + + +IA+ L RVD +EV + Sbjct: 85 VRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSE-----------E 133 Query: 66 DLEWIEAAADVVKH------AKIATLLLPGIGTIHDLKNAWQAG----ARVVRVATHCTE 115 + E I+ A V + + + D++ W+A V + T +E Sbjct: 134 EFEAIKTIAKTVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSE 193 Query: 116 ADV--------------SAQHIQYARELGMDTVGF-LMMSHMTTPENLAKQAKLMEGYGA 160 + + ++YA+ LG + F T + + K GA Sbjct: 194 IHMKYKLKKTKEEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGA 253 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCD 218 T + D+ G + + + + +H H++L + AN+I+ + G Sbjct: 254 TTVGFADTVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGAR 313 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAADKL------GWQHGTDLYALMDAADDL----VRPL 268 +++ ++ G+G +GNAPLE + A G D +M + + + Sbjct: 314 QVEVTINGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYV 373 Query: 269 QDRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVD-ILVELGKRRMVGGQE 323 Q V L++ T G+ + + LGK + Sbjct: 374 QPHKPIVGDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVK 433 Query: 324 DMIVDVALDLRNNK 337 D + ++ ++ + K Sbjct: 434 DRLKELGYEISDEK 447 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 248 bits (633), Expect = 2e-64, Method: Composition-based stats. Identities = 73/363 (20%), Positives = 132/363 (36%), Gaps = 42/363 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ D TLRDG + + + IAK L+ V+ IE +G Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-VVRVATHCTEAD----- 117 D ++ A +K+ +A L G I A + G + V ++ Sbjct: 53 --DFLGVQEIARTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKL 110 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++YA+E + T + LA+ + + GA+ I + D+ Sbjct: 111 KKTREEVVEQAVAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDT 170 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + + + F+ +K + H H +L + VANS+AA+E G D+I+ ++ G Sbjct: 171 VGYLAPKEYGNIFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNG 230 Query: 227 MGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRE 278 +G AGNA LE A + L + +D + + + V Sbjct: 231 IGERAGNAALEEIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVVGNN 290 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A FL+ T G++ ++ LGK +D + + L Sbjct: 291 AFAHESGIHQDGFLKEKTTYEIISPELVGVTTDVLV--LGKHSGRHAFKDRMKTLGFKLT 348 Query: 335 NNK 337 + Sbjct: 349 EEE 351 >UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7 Length = 492 Score = 246 bits (628), Expect = 9e-64, Method: Composition-based stats. Identities = 64/354 (18%), Positives = 125/354 (35%), Gaps = 40/354 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG S +IA LD+ V+ IE +G Sbjct: 2 VNIFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKG----------- 50 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E I+ A+ +A+I++ + D+ A V + ++ + Sbjct: 51 EREAIKLVAEQKLNAEISSFV---RALPVDIDAALSCNVDSVHLVVPTSDLHMEYKLRKT 107 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + YA+E G+ + + E L + K E A I + D+ G Sbjct: 108 REENLKDAMHAVDYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGI 167 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + + +KA + +H H++ + AN+++A+ G D+ ++ G+G A Sbjct: 168 LTPVKSMELIKTMKAAVT--IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERA 225 Query: 232 GNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVRPL----QDRPVRVDRETLALGYAG 286 GNA LE + + L + L + + + + V A Sbjct: 226 GNASLEEVVMSLKSLYDMETNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGI 285 Query: 287 VYSSFLRHCETA---AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ ET + I+ LGK + + + + L + + Sbjct: 286 HVDGLMKSTETYEPIGPEVVGNRRKII--LGKHSGKAALKYKLELMNIGLSHEQ 337 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 246 bits (628), Expect = 1e-63, Method: Composition-based stats. Identities = 70/372 (18%), Positives = 123/372 (33%), Gaps = 52/372 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + D TLRDG + + + IA+ L VD IE + Sbjct: 86 PNYVRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASK--------- 136 Query: 63 AHSDLEWIEAAADVVKHAK-----IATLLLPGIGTIHDLKNAWQA----GARVVRVATHC 113 D E ++ A+ V + + + D++ AW A + Sbjct: 137 --DDFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIAT 194 Query: 114 TEAD--------------VSAQHIQYARELGM-DTVGFLMMSHMTTPENLAKQAKLMEGY 158 ++ ++ +++AR LG D + + E L + + Sbjct: 195 SDIHLEYKLKKTKAEVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKA 254 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEG 216 GAT + + D+ G S+ LKA H ++L L AN+++ G Sbjct: 255 GATTLNIPDTVGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAG 314 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQ------HGTDLYALMDAADDLV----R 266 +++ ++ G+G AGNA LE + A G G D ++ + + Sbjct: 315 ARQMEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGM 374 Query: 267 PLQDRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSA-VDILVELGKRRMVGG 321 Q V A L+H T GL D + LGK Sbjct: 375 QTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHA 434 Query: 322 QEDMIVDVALDL 333 +D + +V +L Sbjct: 435 LKDRLTEVHSNL 446 >UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkholderia RepID=HOA_BURP0 Length = 347 Score = 246 bits (627), Expect = 1e-63, Method: Composition-based stats. Identities = 131/332 (39%), Positives = 187/332 (56%), Gaps = 2/332 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + ISD TLRDG HAIRHQ S + A+A D+A +D +EV HG+GL GSS G Sbjct: 2 ILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGNGLGGSSCLLGQTPIG 61 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D +E A ++ +++ +PG+G D+ A + G VVRVATHCTEA+VSA+ I+ Sbjct: 62 DRLMLETARAALRTSRLGVHFIPGLGKAADISLALEIGVDVVRVATHCTEANVSARFIEQ 121 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 R G G LMMSHM P+ L QAKLME YGA + ++DS G S +R + L Sbjct: 122 TRTAGRTAFGVLMMSHMAPPDTLLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLV 181 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 L + G HAH+NL L VANS+ A+E G +DA + G GAGAGN LE +AA ++ Sbjct: 182 DGL--DIDVGFHAHNNLGLAVANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMER 239 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLS 305 G T +M A L + + +A G G++S ++ H + AA +G++ Sbjct: 240 EGHDTRTTFERVMTLARGTETFLNPKTPHIQPANIASGLYGLFSGYVPHIQKAAQEFGVN 299 Query: 306 AVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L +R++V GQED+I++ A L + Sbjct: 300 EFELYKRLAERKLVAGQEDIIIEEASRLARER 331 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 244 bits (622), Expect = 5e-63, Method: Composition-based stats. Identities = 76/368 (20%), Positives = 132/368 (35%), Gaps = 50/368 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +KL I D TLRDG A ++E ++AK L+ VD IE +G Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKG--------- 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA----RVVRVATHCTEADV- 118 D E + A VK++ + +L D++ A +A A + + + + Sbjct: 63 --DFEAVNEVAKEVKNSTVCSL---ARALHSDIERAGEALAPAERKRIHTFIATSPIHME 117 Query: 119 -------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + +Q+AR D + + E L + + + GA I V Sbjct: 118 YKLRMTPEQVLERAVDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINV 177 Query: 166 VDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G + + + + +H H++L L VANS+ AV+ G ++ ++ Sbjct: 178 PDTVGYAVPEEFGQLISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHST 237 Query: 224 LAGMGAGAGNAPLEVFIAAADKLG-----WQHGTDLYALMDAADDLVR----PLQDRPVR 274 + G+G AGNA LE + A + + + L R +Q Sbjct: 238 INGIGERAGNAALEEVVMAIKVRKDYFKDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAI 297 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V A L ET A G+ + I+ LGK + + ++ Sbjct: 298 VGDNAFAHEAGIHQHGLLAKRETYEIMKAEDVGVPSSKIV--LGKHSGRHAFKTRLEELG 355 Query: 331 LD-LRNNK 337 L + Sbjct: 356 YKNLSEEE 363 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 244 bits (622), Expect = 5e-63, Method: Composition-based stats. Identities = 73/361 (20%), Positives = 131/361 (36%), Gaps = 41/361 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++Y+ D TLRDG Q S +IAKAL+ VD IE G Sbjct: 5 PNRVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPG-------- 56 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEADV--- 118 D + + + V+ I L G I A Q A + ++ + Sbjct: 57 ---DFQSVVEMSKAVQEPIICALTRANKGDIDSAVAALQYAKRPRIHTGIGSSDMHIKYK 113 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + ++YA++ D + + LA+ + + GAT + + D Sbjct: 114 FNSTREKILERAVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPD 173 Query: 168 SGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + LK +K + +H H++L L AN++A + G +I+ ++ Sbjct: 174 TNGYCLPDQYGSKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTIN 233 Query: 226 GMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 G+G AGN LE + LG + D ++ + R P+Q + + Sbjct: 234 GIGERAGNTALEEVVMILKTHHALGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQN 293 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A FL+H E G+++ DI+ L R + + + ++ Sbjct: 294 AFAHSSGIHQDGFLKHRENYEIMNPEDVGINSADII--LTARSGRHALKHHLERLGYEIE 351 Query: 335 N 335 Sbjct: 352 R 352 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 243 bits (620), Expect = 7e-63, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 136/362 (37%), Gaps = 44/362 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG + + E +IA+ L+ RVD IE G Sbjct: 5 LIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNG----------- 53 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ---- 121 D E ++A A +K + I L G I A + GA R+ T + + + Sbjct: 54 DFEAVKAVAAAIKGSTICGLARAIEGDIRRAGEALR-GANSARIHTFIATSPIHMEKKLR 112 Query: 122 ------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 +++AR+ D + + L + + + GA + + D+ Sbjct: 113 MSPDQVVEQAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTV 172 Query: 170 GAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + R L+ + + +H H++L L VANS++AV G +++ ++ G+ Sbjct: 173 GYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGL 232 Query: 228 GAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRET 279 G AGNA LE + A D ++ A+ + P+Q V Sbjct: 233 GERAGNASLEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANA 292 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 A L+H ET A G A +L LGK + ++ ++L + Sbjct: 293 FAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLL--LGKHSGRNAFRSRLAELGIELES 350 Query: 336 NK 337 + Sbjct: 351 EE 352 >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 243 bits (620), Expect = 7e-63, Method: Composition-based stats. Identities = 72/359 (20%), Positives = 132/359 (36%), Gaps = 44/359 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG A++ S++ QIA AL+ VD +EV G Sbjct: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 D E ++ A +K++++ L D+ A++A A R+ T + + Sbjct: 54 ---DFESVQTIARQIKNSRVCGL---ARCVEKDIDAAYEALRVADAYRIHTFLATSPMHI 107 Query: 121 ----------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + I+ AR D T ++L + + GAT I Sbjct: 108 ATKLRSTLPEVIERAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + + F AL+A + + +H H +L + V N++AAV G +I+ Sbjct: 168 IPDTVGYTLPYEYANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEG 227 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLG----WQHGTDLYALMDAADDLVR----PLQDRPVR 274 ++ G+G AGN LE I A G + + + + P+ Sbjct: 228 AMNGLGERAGNCALEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAI 287 Query: 275 VDRETLALGYAGVYSSFLRHCETAAA--RYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 + A L++ E + + + L R + + ++ Sbjct: 288 IGSNAFAHSSGIHQDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGY 346 >UniRef50_A8M6W8 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salinispora arenicola CNS-205 RepID=HOA2_SALAI Length = 348 Score = 243 bits (620), Expect = 7e-63, Method: Composition-based stats. Identities = 133/326 (40%), Positives = 183/326 (56%), Gaps = 3/326 (0%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 KL I D TLRDG HA+ HQ ++ A+A ++A VD +EV HG+GL SS G A Sbjct: 4 KLQICDSTLRDGNHAVAHQLGRADISAYARAAEEAGVDVLEVGHGNGLGASSIQVGIAAV 63 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIG-TIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 SD E + AA ++++++ L +PG DLK A G VRV HCTEADV+ Q I Sbjct: 64 SDAEMLRAAKAELRNSRLGVLSIPGFASVERDLKPALDCGVDEVRVGAHCTEADVTRQQI 123 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 R +G+ G L+MSHM + L +QA LM+ YGA + ++DS GA +R++ Sbjct: 124 TMLRSMGVRVKGLLLMSHMASAGKLVEQAGLMQEYGAEAVVLMDSAGAYTPEMVREKVGE 183 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L +L + G HAH+NL L V NSI AV G +D + G GAGAGNAP+E+ A Sbjct: 184 LVEKL--DIAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGAGNAPIELVAANL 241 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + L+ +DAAD D T+A G AGV+S F A+ R+G Sbjct: 242 HVEQIEARIKLFDALDAADTAEERFVKHVPTNDGVTIASGIAGVFSGFAAPVRRASRRFG 301 Query: 304 LSAVDILVELGKRRMVGGQEDMIVDV 329 + +IL+ELG+RR+V GQED I++V Sbjct: 302 VDPREILLELGRRRVVAGQEDTIIEV 327 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 242 bits (618), Expect = 1e-62, Method: Composition-based stats. Identities = 73/360 (20%), Positives = 130/360 (36%), Gaps = 44/360 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K+ I+D TLRDG A ++LE IAK LD V +EV + Sbjct: 1 MN--KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGE------- 51 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 E + A + A LL I D+K + G V +A + ++A Sbjct: 52 -------EEMRAICAISNLGLKANLLAWNRAVISDIKASVACGMERVHIAIPVSGIQIAA 104 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + I +A + G+ S L A + +GA+ Sbjct: 105 KFHGQWRVSLQRLKDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFC 164 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + + L + L +H H++ + AN++A ++ G ++ ++ G Sbjct: 165 DTVGVLDPFTTYGKVKLLVSALT--IPVEVHTHNDFGMATANALAGIKAGASSVNTTVIG 222 Query: 227 MGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLA 281 +G AGNA LE + A + G G D L++ + + + V T A Sbjct: 223 LGERAGNAALEEVVMAIKRIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFA 282 Query: 282 LGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L++ +T G + +GK +++ + L + Sbjct: 283 HESGIHAHGVLQNPDTYEPFAPEEVGWERRLV---VGKHSGRHSVSNLLEQHGIFLNPEE 339 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 83/367 (22%), Positives = 139/367 (37%), Gaps = 48/367 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+++ I D TLRDG + +L Q+A+AL D VD IE G Sbjct: 5 GQRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFAAASPG-------- 56 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR--VATHCTEADVSA 120 DLE I+A V+ +A+L D++ +W+A A R + + Sbjct: 57 ---DLEAIQAVGRQVEGPIVASL---SRCNKGDIEASWKALADAPRRRCHVFLATSPIHR 110 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ ARE D S T E LA+ + + G + Sbjct: 111 DFKLKLAKDEIIKRSVDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVN 170 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G S + R L+ ++ + +H H++L + VANS+A V EG +++ Sbjct: 171 IPDTVGYALPSTYAETIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVEC 230 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVR 274 ++ G+G AGNA LE + A LG G L + + + +Q Sbjct: 231 TINGIGERAGNASLEEIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAI 290 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V + A L + ET G + ++ LGK +D ++ + Sbjct: 291 VGQNAFAHEAGIHQHGMLTNRETYEIMRPEEVGFARSQLV--LGKHSGRHALKDRLLALG 348 Query: 331 LDLRNNK 337 L + Sbjct: 349 YQLDEAQ 355 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 241 bits (615), Expect = 3e-62, Method: Composition-based stats. Identities = 68/367 (18%), Positives = 129/367 (35%), Gaps = 45/367 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN ++Y D TLRDG + +L+ ++A L+ VD +E G Sbjct: 1 MN-NRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPG------ 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEA-- 116 D E ++ A ++A L D+ W+A AR R+ + + Sbjct: 54 -----DFESVQRIAAQAGDIQVAGL---ARCVAGDIDRCWEAIKNARNPRIHIFLSTSPL 105 Query: 117 --------------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 ++ + ++ + + PE L + + + GAT Sbjct: 106 HMRHKLRKDPDDVLRMAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATT 165 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + + D+ G ++ R + + + +H H++L L VAN++AA G + Sbjct: 166 VNLPDTVGYAQPAEYAARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQA 225 Query: 221 DASLAGMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRP 272 + +L G+G AGNA LE + G +H L + L P+ + Sbjct: 226 EVTLNGIGERAGNASLEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNK 285 Query: 273 VRVDRETLALGYAGVYSSFLRHCETAAA--RYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V A L++ ET + + + +GK + + Sbjct: 286 AIVGANAFAHESGIHQDGMLKNRETYEIMTPQSVGRTESNLVIGKHSGRNAVRNKFEAMG 345 Query: 331 LDLRNNK 337 L +++ Sbjct: 346 YKLDDDQ 352 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 66/369 (17%), Positives = 127/369 (34%), Gaps = 48/369 (13%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +K+ + D TLRDG + ++ +IAK L VD IE G Sbjct: 1 MGDRKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGFPAASNG------ 54 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA----RVVRVATHCTEA 116 + E ++ A+ + +A L D+ ++A + + ++ Sbjct: 55 -----NFEAVKHIAENIDDVVVAGL---SRCVKSDIDKTYEALKNAKKSRIHLFIATSDI 106 Query: 117 D--------------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 ++ ++YA + + T + L K + GA Sbjct: 107 HLKYKLKISRDEALKMAVDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKI 166 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G + +K + K +H H++L + V NS++A+E G D++ Sbjct: 167 INIPDTVGYAVPKEFEKLVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQV 226 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQ----HGTDLYALMDAADDLVR----PLQDRP 272 + ++ G+G AGNA LE I A + H + + + LQ Sbjct: 227 EVTVCGIGERAGNASLEEVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNK 286 Query: 273 VRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVD 328 V + + T G++ I +GK E + + Sbjct: 287 AIVGSNAFRHTAGIHQHGVINNKATYEIMRPEDIGITTDHI--SMGKLSGRNAFELKLKN 344 Query: 329 VALDLRNNK 337 + +L ++ Sbjct: 345 MGYELSRDE 353 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 240 bits (612), Expect = 7e-62, Method: Composition-based stats. Identities = 71/357 (19%), Positives = 123/357 (34%), Gaps = 42/357 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K +YI D TLRDG ++ E +IA+ LD+ + IE + Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSER--------- 72 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD------ 117 + + ++ A+ +A I L D+ A + + + Sbjct: 73 --EADIVKTIANEGLNADILAL---CRALKKDIDKAIECDVDGIITFIATSPLHLKYKFN 127 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++YA+E G+ + T E+L K K E GA +++ D+ Sbjct: 128 NKSLDEILEMGVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADT 187 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + LK LK G+H H++ V NSI + G + ++ G+G Sbjct: 188 TGCATPQSMEFICKTLKENLKK-AHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIG 246 Query: 229 AGAGNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALG 283 AGNA LE I A L G +L L + + + V A Sbjct: 247 ERAGNAALEELIMALTVLYDVDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHE 306 Query: 284 YAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + + + T + GL + LGK + + +D Sbjct: 307 SGIHVDAVIENPLTYEPFLPEKIGLKRNIL---LGKHSGCRAVAYKLKLMGIDYDRE 360 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 72/364 (19%), Positives = 123/364 (33%), Gaps = 42/364 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+++I D TLRDG A S E IAK L D VD IE G Sbjct: 2 TKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW-QAGARVVRVATHCTEAD---- 117 D ++ + V +I I A A R + + + Sbjct: 54 ---DFMAVQRISQEVHGVEICGFARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQ 110 Query: 118 ----------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 ++ + I Y ++ M + T E L + + GAT I + D Sbjct: 111 LRKSREQVIKIAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPD 170 Query: 168 SGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + F + + + + H H++L L VANS+AA+ G +++ ++ Sbjct: 171 TVGYALPEEYGAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVN 230 Query: 226 GMGAGAGNAPLEVFIAAADKLG----WQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGN LE + A + + + + + R P+ V R Sbjct: 231 GVGERAGNCSLEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVGR 290 Query: 278 ETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDL 333 L+ T G+ I+ LGK + + + + L Sbjct: 291 NAFQHEAGIHQDGLLKERSTYEIMDPESLGVPRNMII--LGKHSGRHAIKHRVNEFGIQL 348 Query: 334 RNNK 337 + + Sbjct: 349 TDEQ 352 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 71/358 (19%), Positives = 129/358 (36%), Gaps = 43/358 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I+D TLRDG A + + IA LD V IEV + Sbjct: 1 MNSS-ITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVGIPAMGAVET---- 55 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 E I A + A + D+ + + G + + ++ ++ ++A Sbjct: 56 -------EAIRAMLSLGLRAHLLG---WNRAVPSDILASIRCGLKRIHISVPVSDRQIAA 105 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + ++ A E G+ + T+ E + + A++ + +G Sbjct: 106 KFQGDRPRLLRQLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYC 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + R L + + MH H +L + AN++A + G ++ ++ G Sbjct: 166 DTVGVLDPFSTYKQIRRLVRAI--DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNG 223 Query: 227 MGAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLA 281 +G AGNAPLE + A LG G D L + + + R PL V A Sbjct: 224 LGERAGNAPLEEVVMALRCTLGIDVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFA 283 Query: 282 LGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + LR +T G + LGK ++ + + + Sbjct: 284 HESGIHAAGVLRDPQTYEPFPPEAVGSQRRLV---LGKHSGRHLLLQILKEHGIPVEQ 338 >UniRef50_D0IC26 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0IC26_VIBHO Length = 355 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 101/334 (30%), Positives = 164/334 (49%), Gaps = 3/334 (0%) Query: 4 KKL-YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + I + TLRDG + I Q+S + I KALD A + IEV HG GL S N G Sbjct: 2 KNIPTILECTLRDGSYEIDFQFSKKQTSDICKALDTAGFELIEVGHGVGLGASEKNIGVA 61 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +D ++EAAA+ VK+ K +PGI H L A +R+ + + S++ Sbjct: 62 LETDEVYMEAAANNVKNGKWGMFAIPGIAEKHHLDIASDYDMDFIRIGSTIEDFPKSSEF 121 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I A+ L M T M S+ + PE LA + G +YVVDS G M +++++ Sbjct: 122 IDKAKSLSMMTCVNFMKSYTSKPEKLAIASSAAFEMGVDVVYVVDSAGGMLPNEVKNYVE 181 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 A+KAE G H H+NL LG+ N++AA+ G ID SL G G AGN E + Sbjct: 182 AIKAE-NTNAIVGFHGHNNLGLGIGNALAALNAGASIIDTSLQGFGRSAGNTTTEQMLGC 240 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 ++G + D +MD ++L++PL ++ +T++ G + +SS++ + +Y Sbjct: 241 LARMGIEGKIDPIVVMDIGEELIKPLIEKRGLTSLDTVS-GISLFHSSYMPTIHDMSVKY 299 Query: 303 GLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + ++V + +V +++ A + Sbjct: 300 RVDPRLLIVSVCSEDIVNANAELVEKHAKLIAEE 333 >UniRef50_Q0YTT0 Pyruvate carboxyltransferase n=1 Tax=Chlorobium ferrooxidans DSM 13031 RepID=Q0YTT0_9CHLB Length = 681 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 100/321 (31%), Positives = 159/321 (49%), Gaps = 3/321 (0%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + I +Q++ + IA L+ + ++ IEV HG GL G A + Sbjct: 8 VDILDTTLRDGSYTIGYQFTADETALIAHGLELSGINYIEVGHGLGLGADRAGKGAQAVT 67 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 DL ++ A ++ ++ A+ +PGIG + DLK G VRV D + I+ Sbjct: 68 DLVYMRACSNAIRRARFGFFYIPGIGELSDLKLLADEGGAFVRVGVSLDAIDQACHAIRE 127 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 A+ LG++ +M + + + + + GA +YVVDS G M S++ + ++ Sbjct: 128 AKRLGLEVWANIMKIYAYSLKESREGSLRFVEAGADGVYVVDSAGGMLPSEVAEYVSEIR 187 Query: 186 AEL---KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 E + G H H NLSL A S++AV GCD +D SL G+G GNA EV Sbjct: 188 KEFTLAGVSARIGFHGHDNLSLSTACSLSAVGAGCDIVDGSLLGIGRSIGNAATEVLAMV 247 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARY 302 + G++ G + + D A+ +RP ++ R ALG+A ++S FL E AA +Y Sbjct: 248 LCRAGYETGVNAWNAGDLAEKTIRPFLEQRWRHSSLEQALGFAQIHSGFLPLLEKAALQY 307 Query: 303 GLSAVDILVELGKRRMVGGQE 323 +S D+++ LG E Sbjct: 308 QISLRDVVLVLGHDAKRHISE 328 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 239 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 66/344 (19%), Positives = 121/344 (35%), Gaps = 16/344 (4%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I D TLRDG + +++ +IA L D VD IE S Sbjct: 26 KKRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKI 85 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D +I A I +++ GI IH + + + Sbjct: 86 HEMDGNFISLAR--CNRHDIDSVIDTGIDNIHLFIATSDIHIKYKLKTSRENIMEKIVDS 143 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 I YAR G++ + + T L GA I + D+ G MN + + Sbjct: 144 IDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYNFIH 203 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 +K ++ +H H++ + AN++AA+ G D ++ G+G AGNA LE + + Sbjct: 204 EIKNR--TKSCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALEEVVLS 261 Query: 243 ADKL-GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 G ++ + + + +Q V + + + ET Sbjct: 262 VHAFTDCSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIHVHGLINNPET 321 Query: 298 A----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 GL+ + LGK + ++ + +++ Sbjct: 322 YEPIDPGILGLNRRIV---LGKHSGTTSLKYILESHGIKKSDDE 362 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 67/363 (18%), Positives = 130/363 (35%), Gaps = 42/363 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG + E IA+ L VD IE G Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAW-QAGARVVRVATHCTEAD----- 117 + I+ + +++ +I I A A R + + ++ Sbjct: 53 --EFAAIQQISRELQNVEICGFARAVKVDIDAAVKATQDAAKRRLHLFISSSDIHLSHQI 110 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ I YA++ + M S + + + + + GAT I + D+ Sbjct: 111 RKTRSEVVQIARDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPDT 170 Query: 169 GGAMNMSDIRDRFRALKA--ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G +++ D F +++ + + H H++L + VANS+AAV+ G +++ ++ G Sbjct: 171 LGYALPNEMVDLFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVNG 230 Query: 227 MGAGAGNAPLEVFIAAADKLG----WQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGN LE + + + + + + R P+ V R Sbjct: 231 VGERAGNCSLEELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGRN 290 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 L+ T G+S I+ LG+ + + + + + Sbjct: 291 AFQHESGIHQDGLLKDRSTYEIMDPEAMGISRSMII--LGRHSGRHAIKHRLSEYGIAVA 348 Query: 335 NNK 337 +N+ Sbjct: 349 DNE 351 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 237 bits (604), Expect = 5e-61, Method: Composition-based stats. Identities = 81/359 (22%), Positives = 131/359 (36%), Gaps = 44/359 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I D TLRDG + + +IA+ L VD +E G Sbjct: 8 PNQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGFPIASPG-------- 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 D E +E A V+ IA L +G I NA + A R+ T + +D+ +H Sbjct: 60 ---DFEAVETIARQVEGPVIAGLARIHVGDIDAAWNALRD-ASRPRIHTFVSTSDIHIEH 115 Query: 123 ----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + +A++ D M + + E A+ ++ GAT I + Sbjct: 116 QMRSTREDVIGLTRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIP 175 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + L + +H H +L L VANS A V G +++ ++ Sbjct: 176 DTVGYTMPHEYTAFLGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECAI 235 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYA----LMDAADDLVRP----LQDRPVRVD 276 G+G AGNA LE + G D A + A+ + R +Q V Sbjct: 236 NGLGERAGNASLEEIVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIVG 295 Query: 277 RETLALGYAGVYSSFLRHCET----AAARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 R A L++ ET A GL + ++ LGK D + + + Sbjct: 296 RNAFAHESGIHQDGVLKNRETFEIMDATSIGLDSNSLV--LGKHSGRHALRDALAQLGI 352 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 67/363 (18%), Positives = 120/363 (33%), Gaps = 41/363 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +L+I D TLRDG Q + Q+AKAL+ VD IE G Sbjct: 2 SDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNA---------------WQAGARVV 107 D + + + V I L I A + + Sbjct: 54 ---DFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYK 110 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 +T + + +YA++ D + + T E LA+ + + GAT + + D Sbjct: 111 FNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPD 170 Query: 168 SGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + + + L + H H++L + AN++ V G +++ ++ Sbjct: 171 TTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTIN 230 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQ---HGTDLYALMDAADDLV----RPLQDRPVRVDRE 278 G+G AGN LE + + + + P+Q V R Sbjct: 231 GIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRN 290 Query: 279 TLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A L++ +T G+ I+ L R + + + +DL Sbjct: 291 AFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIV--LTARSGRAALKHRLHVLGVDLE 348 Query: 335 NNK 337 K Sbjct: 349 QEK 351 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 236 bits (602), Expect = 1e-60, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 120/343 (34%), Gaps = 12/343 (3%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I D TLRDG A +++ +IA+ LD+ V+ IE+ G Sbjct: 16 PDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAAREM 75 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 V I L+ + H + S + Sbjct: 76 VSLGFSSELCGLARVVQKDIDALIDSDLSYAHLFIGTSPLHRDYKLKKSKTEILSQSMEM 135 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 ++YA++ G+ + T L + K +E GA I V D+ G + S R R Sbjct: 136 VEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTTRTLIR 195 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAA 242 L+ ++ +H H++ L V+NS+ +EEG ++ ++ G+G AGN LE + + Sbjct: 196 TLRKKI--NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTSLEELVVS 253 Query: 243 AD-KLGWQHGTDLYALMDAADDL----VRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 G D L D ++ + + V A L++ T Sbjct: 254 LKIAYGANLTVDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIHVDGILKNSST 313 Query: 298 A---AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 A I LGK + + + +++ + Sbjct: 314 YEPIAPEIVGHKRRI--ALGKHTGHAAIKSKLEEFNIEVTQKQ 354 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 236 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 68/362 (18%), Positives = 136/362 (37%), Gaps = 45/362 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN ++ I D TLRDG A++ S++ QIA +L++ +D IEV G Sbjct: 1 MNS-QVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPG------ 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTE--- 115 D + ++ + +K+++I +L D+ A +A + R+ Sbjct: 54 -----DFKSVQTISKNIKNSRICSL---ARCLDKDIDAAAEAMHSSNAFRIHIFLATSIL 105 Query: 116 -------------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 D++ ++ A D + TT +NL + + + G Sbjct: 106 HMESKLKKNFDQIIDMAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKT 165 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G +++ L + ++ +H H++L + V NSI+A++ G +I Sbjct: 166 INIPDTVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQI 225 Query: 221 DASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRP 272 + ++ G+G AGN LE I A D LG + + + + P+ Sbjct: 226 EGTINGIGERAGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNK 285 Query: 273 VRVDRETLALGYAGVYSSFLRHCETAA--ARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V A L++ + + ++ + L R + + ++ Sbjct: 286 AIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMG 345 Query: 331 LD 332 Sbjct: 346 YR 347 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 65/367 (17%), Positives = 127/367 (34%), Gaps = 49/367 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++I D TLRDG Q + Q+A++L+ VD IE G Sbjct: 8 KNSVFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPG-------- 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 D + + V I L D+ A ++ A+ R+ T + Sbjct: 60 ---DFNSVIEISKSVTWTIICALT---RAIEKDIDIAAESLQYAKRKRIHTGIGTSPYHI 113 Query: 121 QH----------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ ++YA++ D + + T LA+ + + GA + Sbjct: 114 KYKFNSTQDEILERAVASVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVN 173 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + + + L +K H H++L + AN+I+ + G +++ Sbjct: 174 IPDTTGYCLPEEYGAKIKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEV 233 Query: 223 SLAGMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 ++ G+G AGN LE + +L + + + + P+Q V Sbjct: 234 TINGIGERAGNTSLEEVVMIIKSHKELNIGTNINTKHIYPISRMISSLMNMPVQPNKAIV 293 Query: 276 DRETLALGYAGVYSSFLRHCETAAARYGLSAVDI-----LVELGKRRMVGGQEDMIVDVA 330 R A L++ E + DI ++ L R + + + Sbjct: 294 GRNAFAHSSGIHQDGILKNRENYEI---IDPKDIGIDNNIIALTARSGRAALKYRLNILG 350 Query: 331 LDLRNNK 337 ++L K Sbjct: 351 IELSQKK 357 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 235 bits (600), Expect = 2e-60, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 119/353 (33%), Gaps = 37/353 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L I D TLRDG ++E IA+ALDD VD IE Sbjct: 2 LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAG-----------TAIAGEE 50 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + ++ A+ A+I + D+ A A V + ++ + Sbjct: 51 EFRAVKEIANAGLKAEICSF---ARIKEIDIDAVANADADSVFMVAPSSDIHIKTKFPNK 107 Query: 119 --------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 S + ++YA+E G+ S + + + GA + D+ G Sbjct: 108 SGDDIIEMSVKAVEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVG 167 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + R L +E H H++ L AN+I AV+ G I ++ G+G Sbjct: 168 VLTPEKAECIMRELTSEF--NVPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGER 225 Query: 231 AGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGNAPLE + A + G + + D + + P+ V Sbjct: 226 AGNAPLEEVVLALETFYGIKTKIRKEKIYDTSKLVEALTRFPIALNKPIVGYNAFMHESG 285 Query: 286 GVYSSFLRHCETA-AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 S+ LR+ + + + GK +I ++ + + Sbjct: 286 IHTSALLRNAKAYEPISPEMIGRKRAIVHGKHSGKASIMRLIEELGYEASGEQ 338 >UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN Length = 576 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 68/361 (18%), Positives = 116/361 (32%), Gaps = 38/361 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++L + D TLRDG + + + IA+AL VD E G Sbjct: 31 KERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPGDFDAVSAI 90 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA--GARVVRVATHCTEADVSA 120 A I + T+ D++ + A A R+ T +D+ Sbjct: 91 AKE----IGPITAGRPTGEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFLATSDIHL 146 Query: 121 Q----------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 Q +++A+ L D + + P+ L + GAT + Sbjct: 147 QYKLKISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIKAGATTLN 206 Query: 165 VVDSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + F L + H H++L L AN++AAV+ G + + Sbjct: 207 IPDTVGYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQGGARQAEV 266 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVR 274 ++ G+G AGN LE + A D + + + +Q Sbjct: 267 TINGIGERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMSIQPNKAI 326 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V A L+H T GLS ++ LGK + + Sbjct: 327 VGSNAFAHESGIHQDGVLKHQATYEIMLPESVGLSENKMV--LGKHSGRHAYSKRLQQLG 384 Query: 331 L 331 Sbjct: 385 Y 385 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 233 bits (595), Expect = 6e-60, Method: Composition-based stats. Identities = 67/363 (18%), Positives = 129/363 (35%), Gaps = 44/363 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I D TLRDG A++ S++ QIA AL+ VD +EV G Sbjct: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------- 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEADVSA 120 D E ++ A +K++++ L D+ A ++ A R+ T + + Sbjct: 54 ---DFESVQTIARTIKNSRVCAL---ARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHI 107 Query: 121 Q----------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 ++ AR D + T +LA+ + GAT I Sbjct: 108 ATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 Query: 165 VVDSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G + + L + + +H H +L + V N++AAV G +++ Sbjct: 168 IPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEG 227 Query: 223 SLAGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLV----RPLQDRPVR 274 ++ G+G AGN LE I A + + + + + + P+ Sbjct: 228 AMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAI 287 Query: 275 VDRETLALGYAGVYSSFLRHCETAAA--RYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 V A L++ E + + + L R + + ++ Sbjct: 288 VGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQ 347 Query: 333 LRN 335 + Sbjct: 348 ESD 350 >UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034 Length = 497 Score = 232 bits (593), Expect = 9e-60, Method: Composition-based stats. Identities = 66/360 (18%), Positives = 125/360 (34%), Gaps = 44/360 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + +IA LD+ V+SIE +G Sbjct: 2 KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSAITSEG---------- 51 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------ 118 + E I+A +A+I + I D+ + V + ++ + Sbjct: 52 -EREAIKAITSQGLNAEIVSF---SRTLIKDVDYCLECDVDAVNIVVPTSDLHLQYKLKK 107 Query: 119 --------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + +YA++ G+ S T + L K K GA I D+ G Sbjct: 108 TQDEMLEDAVKVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLG 167 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + ++ H H++ L VAN+++A++ G R A++ G+G Sbjct: 168 ILTPLKSFNFYKQFTD---LGVPVSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGER 224 Query: 231 AGNAPLEVFIAAADKLG--------WQHGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 AGNA LE + + L ++ + + + + R L V Sbjct: 225 AGNAALEEVVVSLYTLYKDESNERKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGEN 284 Query: 279 TLALGYAGVYSSFLRHCETA-AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 A +++ T L +GK G + + ++ L++ + Sbjct: 285 AFAHESGIHADGVIKNSATYEPIMPELVGHRRKFVIGKHVGTKGLNNRLEELGLEVNKKQ 344 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 50/366 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + S+E +IA L +VD IE +G Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGFPITSEG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA----RVVRVATHCTEADV- 118 D E + A V+ IA L D++ AW+A + ++ + Sbjct: 53 --DFEAVSRIASEVEGPVIAGL---ARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIE 107 Query: 119 -------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 +A+ ++ A+ L + M + T LA+ GA I + Sbjct: 108 HQMRSTREEILSGAAEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINI 167 Query: 166 VDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 D+ G ++ R LK + E +H H +L + VANS+A VE G +++ + Sbjct: 168 ADTVGYTTPAEFAAFLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVA 227 Query: 224 LAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRV 275 + G+G AGNA LE + A D G + G + L + + + + V Sbjct: 228 VNGIGERAGNASLEEVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVV 287 Query: 276 DRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVE-----LGKRRMVGGQEDMIVDVA 330 R L+ T + DI +E LGK ++ + D+ Sbjct: 288 GRNAFLHESGIHQDGVLKDRRTFEI---MKPADIGLEGTNIFLGKHSGRHALKEALADLG 344 Query: 331 LDLRNN 336 L Sbjct: 345 YTLEGE 350 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 117/356 (32%), Gaps = 43/356 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ + D TLRDG + E +IA +D D IE +G Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEG---------- 51 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD------- 117 + E I A+I + D+ A V + ++ Sbjct: 52 -EREGIRKITSEGLRAEICSF---ARAVREDIDAAISCDVDSVHLVVPTSDLHLEHKLRK 107 Query: 118 -------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + +YA + G+ S + + L + GA I D+ G Sbjct: 108 TREEVLEQAVDCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVG 167 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + +R L +H H++ L VANS+A + G + A++ G+G Sbjct: 168 ILTPERSYEFYRGLSE---LGAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGER 224 Query: 231 AGNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGNA LE + A L ++ L + + + R LQ V A Sbjct: 225 AGNAALEEVVVALKSLYDVDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESG 284 Query: 286 GVYSSFLRHCETAAARYGLSAVDILV----ELGKRRMVGGQEDMIVDVALDLRNNK 337 L+ ET ++ + +GK + ++ + + ++K Sbjct: 285 IHADGVLKKAETYEP---ITPEMVGHGRGFVMGKHIGTHALRKRLDELGMKVADDK 337 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 79/363 (21%), Positives = 119/363 (32%), Gaps = 44/363 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ + D TLRDG A +++ +A L D VD IE G Sbjct: 9 PNRVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPG-------- 60 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA-- 120 D E I A V +L I A A+ R + + Sbjct: 61 ---DEEAIRTIAREVVGPTFCSLSRALESDIDAAARAL-LPAKRKRCHIFLATSPIHRAA 116 Query: 121 --------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + YA + + + T + L + GA + + Sbjct: 117 KLKKTREQVVEIAHKAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLNIP 176 Query: 167 DSGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G +I F LKA LK P+ H H +L LGVAN++AA+E G +I+ ++ Sbjct: 177 DTVGYTTPKEIYQIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEVTI 236 Query: 225 AGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVRP----LQDRPVRVD 276 G+G AGNA LE + A G + L A+ L R + V Sbjct: 237 NGIGERAGNAALEEVVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAVVG 296 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 R A L T G +++ LGK + D Sbjct: 297 RNAFAHESGIHQHGMLTDARTYEIMRPEDVGAEKSNLV--LGKHSGRHAIAKQAAALGFD 354 Query: 333 LRN 335 L Sbjct: 355 LDE 357 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 62/360 (17%), Positives = 126/360 (35%), Gaps = 43/360 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 KK+ I D TLRDG ++ E IA+ L D VD +EV Sbjct: 8 TNKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVGIPTMGG-------- 59 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 + +A ++VK +++ + D++ + G V ++ ++ + Sbjct: 60 ------DEKKAIKEIVKRNLKPSIMAWNRAVVSDIEQSIDCGVDAVAISISVSDIHIQHK 113 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + +++A++ G+ + + L + + GA D Sbjct: 114 LKTSREWVLESMVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCD 173 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G M IRD + + + + MH H + + AN++A ++ G + ++ G+ Sbjct: 174 TVGIMEPFKIRDDIKYIYDKTGFD--IEMHTHDDFGMATANAVAGIKGGASHVGVTVNGL 231 Query: 228 GAGAGNAPLEVFIAAADKLGWQH--GTDLYALMDAADDLV----RPLQDRPVRVDRETLA 281 G AGNA LE I A + + G + + + + R L V A Sbjct: 232 GERAGNAALEEVIMALMLVYGYNGDGINTQMFREVSQYVSRASGRELPIWKAIVGTNMFA 291 Query: 282 LGYAGVYSSFLRHCETAAARYGLSAVDILVE----LGKRRMVGGQEDMIVDVALDLRNNK 337 ++ + A + +E +GK + + +L ++ Sbjct: 292 HESGIHADGAIKDPKNYEA---FDPDIVGLERQIVIGKHSGRASIINKFREYNRELTEDE 348 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 230 bits (587), Expect = 5e-59, Method: Composition-based stats. Identities = 77/370 (20%), Positives = 126/370 (34%), Gaps = 47/370 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 ++ I D TLRDG + S +A+ALD+ VD IE Q Sbjct: 8 TTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQ-------- 59 Query: 62 GAHSDLEWIEAAADVVKHAKI--ATLLLPGIGTIHDLKNAWQAGA-RVVRVATHCTEADV 118 SD + + ++ + A L I A +A A + V + Sbjct: 60 ---SDRDAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHR 116 Query: 119 --------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 +H+ AR D + T + L + ++ GAT I Sbjct: 117 EHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTIN 176 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP-----ETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 + D+ G +IR+ F+ + A + H H++L L VANS+AA+E G + Sbjct: 177 LPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQ 236 Query: 220 IDASLAGMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDR 271 ++ ++ G+G AGN LE + ++ + L R P+Q Sbjct: 237 VECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRN 296 Query: 272 PVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIV 327 V A LRH T G D + LG+ E + Sbjct: 297 KAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWE--DSQMVLGRHSGRAAVEARLR 354 Query: 328 DVALDLRNNK 337 + L ++ Sbjct: 355 ALGFWLEEDE 364 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 73/377 (19%), Positives = 121/377 (32%), Gaps = 56/377 (14%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ I D TLRDG + +LE IA+ L VD IE F Sbjct: 5 PGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFP-----------FA 53 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA----RVVRVATHCTEAD- 117 + D ++ A V + + + D+K A A R + ++ Sbjct: 54 SQGDFSAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHL 113 Query: 118 -------------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + + + YAR L D + + PE L + + GA I Sbjct: 114 EHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTIN 173 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKP--ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + D+ G S+ + + E +H H++L L VAN + AV+ G + + Sbjct: 174 IPDTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFEC 233 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLGWQ---------------HGTDLYALMDAADDLV-- 265 ++ G+G AGNA LE + A + + + Sbjct: 234 TINGIGERAGNAALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNL 293 Query: 266 --RPLQDRPVRVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMV 319 +Q V A L++ T A GL+ I LGK Sbjct: 294 TGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRI--SLGKLSGR 351 Query: 320 GGQEDMIVDVALDLRNN 336 + ++ DL Sbjct: 352 SAVRARLEELGYDLTRE 368 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 230 bits (586), Expect = 7e-59, Method: Composition-based stats. Identities = 66/359 (18%), Positives = 124/359 (34%), Gaps = 41/359 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M + I DVTLRDG ++ + + IA LD ++ IE Sbjct: 1 MKPWHIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAH------ 54 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD--- 117 + E + + + AKI L D+ A A ++ + ++ Sbjct: 55 -----EKEMVRNISRLGLSAKICGLSRACR---EDVDAALDAEVDMIGLFIAPSDLHLKY 106 Query: 118 -----------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + + YA + G+ + T P+ L + + AT + Sbjct: 107 KHKKPRDVVVANALEQLDYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYA 166 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + ++ + L + MHAH++L AN++ A E G ++ ++ G Sbjct: 167 DTTGCLTPLEVATVMKDLVPKTP--IPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNG 224 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLAL 282 +G AGNA LE + + G DL + ++ + + + V A Sbjct: 225 LGERAGNARLEEVLVSLVLKGGITRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAH 284 Query: 283 GYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L + ET GL I LGK ++ + + + Sbjct: 285 ESGIHIAAILENPETYEFIPPELLGLERRFI---LGKHTGKRALVHILTSFGYHITDEQ 340 >UniRef50_Q8KZT0 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus jostii RHA1 RepID=Q8KZT0_RHOSR Length = 359 Score = 229 bits (584), Expect = 1e-58, Method: Composition-based stats. Identities = 158/335 (47%), Positives = 200/335 (59%), Gaps = 8/335 (2%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG HA HQ++ VR +ALD A V+ IEV HGDGL GS+FNYGF S Sbjct: 10 VRIVDTTLRDGSHAQSHQFTESQVRDTVRALDGAGVEVIEVTHGDGLGGSTFNYGFSRIS 69 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 DLE ++ AAD + AKIA LL+PGIGT DL+ A GA VVR+ATHCTEADVS QH + Sbjct: 70 DLELVQVAADTAEQAKIAVLLVPGIGTADDLRKAADRGAEVVRIATHCTEADVSLQHFEI 129 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 AR+LGM T GFLMM+H TTPE LA+QA+LM G YV DS GA+ M + +DRF AL Sbjct: 130 ARDLGMQTCGFLMMAHRTTPEELARQARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALI 189 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADK 245 E+ + G H H N+SLGVANS+ A E G ID SL +GAG+GN+P E+ A D+ Sbjct: 190 TEVGDDAWVGYHGHQNMSLGVANSVIAYEAGVRYIDGSLCALGAGSGNSPTELLAAIFDR 249 Query: 246 LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGV----YSSFLRHC-ETAAA 300 + + + + D V R+++ + V YSSFL H + Sbjct: 250 MNIRDRARRDGDIGCSRD---SWCGPTSTVGRKSIGMRSCRVGSAWYSSFLLHAGDRGRP 306 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + A + V VGGQEDMI+DVA+ L Sbjct: 307 VWRSGARESCVAAANWGYVGGQEDMIIDVAIQLAK 341 >UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4 Length = 380 Score = 227 bits (579), Expect = 5e-58, Method: Composition-based stats. Identities = 69/360 (19%), Positives = 114/360 (31%), Gaps = 43/360 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MNGK + ++D TLRDG A +S QI K L + IE + Sbjct: 1 MNGK-ILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCK------- 52 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-- 118 +++E + +I G T DL+ + V ++ ++ + Sbjct: 53 ----TEMEAFHKILSLGLKVRIVA---WGRMTNEDLQAVKSSRVSTVNLSIPLSDIQIST 105 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +++ ARE+G++ S L + ++ + GA Sbjct: 106 KLRTNRKQVLEKIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYA 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ LK H H + + ANSIAA G I A+L G Sbjct: 166 DTVGILDPLCTYQTLSRLKK--WTSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCG 223 Query: 227 MGAGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDA----ADDLVRPLQDRPVRVDRETLA 281 +G AGN LE + G DL L + R + + E Sbjct: 224 LGERAGNGALEEIAFFLALRENVDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFL 283 Query: 282 LGYAGVYSSFLRHCETAAARYGLSAVDILVE----LGKRRMVGGQEDMIVDVALDLRNNK 337 L++ + I + LGK + + L K Sbjct: 284 HESGIHVDGILKNPRNYEP---FNPSIIGRKHRFTLGKHSGRKSVLWTYEKLGITLSEQK 340 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 227 bits (578), Expect = 6e-58, Method: Composition-based stats. Identities = 55/349 (15%), Positives = 120/349 (34%), Gaps = 47/349 (13%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N + + I D TLRDG ++ + +IAK L DA V+ IE Sbjct: 26 NRENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSN-------- 77 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 + +++ + + + + +D+ ++ +R++ + ++ + Sbjct: 78 ------DEMKSIKKI--NHDMENICSLARCNRNDIDKVIESDSRIIHLFIATSDIHMKYK 129 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I YAR GM + + T+ + L + + I D Sbjct: 130 LKKTREQVFDSIMESIDYARSYGMRIIFSPEDATRTSMDFLKQI---VSSIKVETINFPD 186 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G MN + +K+ +H H++ + AN++A + G + ++ G+ Sbjct: 187 TIGIMNPISMYYFINKIKSFTSTG--ISIHCHNDFGMATANTLAGLMAGANEAQVTVNGI 244 Query: 228 GAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRPL----QDRPVRVDRETLAL 282 G AGNA LE +++ L + L + + Q + Sbjct: 245 GERAGNASLEEVVSSIYGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSH 304 Query: 283 GYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIV 327 + + +T +GL+ ++ GK + ++ Sbjct: 305 EAGIHVQGIINNPKTYEAINPEIFGLNRRIVI---GKHSGKAAIKYILE 350 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 226 bits (577), Expect = 7e-58, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 129/366 (35%), Gaps = 49/366 (13%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+Y+ D TLRDG + + E IAK L+ RVD +E QG Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQG--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR----VVRVATHCTEADVS 119 D E + + +K + + L G D+ +++ ++ + + ++ Sbjct: 53 --DFEAVREISRQIKDSSVVAL---GRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHIT 107 Query: 120 AQ--------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + + YA+ L + + E + + + + GATC+ + Sbjct: 108 KKFNKNPEDILQMGVDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNI 167 Query: 166 VDSGGAMNMSDIRDRFRAL---KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ G + + P +H H++ L AN++AAV G ++++ Sbjct: 168 PDTVGFAVPELFGGLIHQIYDRLQNVAPHVLLSVHCHNDSGLATANTLAAVRNGANKVEC 227 Query: 223 SLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVRPL----QDRPVR 274 ++ G+G AGN LE + + + A+ + + + R + Q Sbjct: 228 TINGIGERAGNTSLEEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKAL 287 Query: 275 VDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 V A L+ E + G +DI+ L R E + + Sbjct: 288 VGENAFAHSSGIHQDGLLKSKEVYEIFEPSDIGAPPMDIV--LTARSGKHAFEYISKKLG 345 Query: 331 LDLRNN 336 ++ Sbjct: 346 YEIAPE 351 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 226 bits (577), Expect = 7e-58, Method: Composition-based stats. Identities = 61/356 (17%), Positives = 120/356 (33%), Gaps = 45/356 (12%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + D TLRDG + +S ++ RQIA LD+ IE + Sbjct: 59 RVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDA-----------E 107 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-------- 118 E + A T D++ A +G +V ++ + Sbjct: 108 FEAVRDIASSTS----TTTCGLARVVDADIEAALDSGVEMVHTFVSTSDVQIEDSMHATR 163 Query: 119 ------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + ++ E G + M + T + L + + + G I + D+ G Sbjct: 164 DEVVERAVESVERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVA 223 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + R + A + + +H H + L AN++A +E G D+ S+ +G AG Sbjct: 224 TPTRFRAMIEKVCAH--TDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAG 281 Query: 233 NAPLEVFIAAADKLGW-QHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 NA E F+ A + L G D + + ++ + V + Sbjct: 282 NAAYEEFVMAVESLYQTDTGIDTTRITELSNVVEEKSGMATPGNKPVVGDNAFSHESGIH 341 Query: 288 YSSFLRHCETA------AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + + + +T G I LGK + + ++ + +++ Sbjct: 342 AAGVIENSDTFEPGVMTPEMVGAERRLI---LGKHTGTHSVRERLAELGFEPTDDQ 394 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 69/360 (19%), Positives = 122/360 (33%), Gaps = 46/360 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K + D TLRDG +Y+ E +IA+ LD A ++SI+ + + Sbjct: 16 KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLS------ 69 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------ 118 I D+ +I ++ D+ A G V + ++ + Sbjct: 70 -----IRKICDLGLKMRIMSM---CRVIREDIDFASSCGVEGVILFIPGSDIHLKAKFGE 121 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + I+YA++ G+ + S T L + E GA + Sbjct: 122 DIPAVRKNIVQKAMDAIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTT 181 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + + + L LK G+H H+++ L AN+IA + G ++ G Sbjct: 182 DTIGYLTPERTYNFIKKLVRNLK--LPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNG 239 Query: 227 MGAGAGNAPLEVFIAAADKLGW-QHGTDLYALMDAADDLVRP----LQDRPVRVDRETLA 281 MG AGNA LE I L D L + + + + + V + + Sbjct: 240 MGERAGNASLEEVIMILKVLYNQDLKYDTKILGELSKTVEKYSGISMDIFKPIVGQNAYS 299 Query: 282 LGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L+ T G S E+GK + ++ +L + Sbjct: 300 HESGIHVHGMLKDINTYELFDPQLVGHSRKY---EMGKHAGKHTIQHILKTNGFELSEEE 356 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 67/350 (19%), Positives = 123/350 (35%), Gaps = 42/350 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG +SLE + IA+ LDD V +E A Sbjct: 9 IIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECG-------------IPAMG 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 E + +V A L+ + D++ + Q G V ++ ++ + Sbjct: 56 REEQ-RSVKALVDLGLHARLITWNRALVDDIRASLQCGVNAVDISLSVSDLHIRHKLRKD 114 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + +A++ + + + L + +L GA D+ G Sbjct: 115 RHWVREQLKRALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGL 174 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ ++ R L + + +H H++L + AN+IA V G I+ ++ G+G A Sbjct: 175 LDPFVTFEKIRYLTQRV--DLDIEVHTHNDLGMATANAIAGVRAGARFINTTVNGLGERA 232 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAG 286 GNA LE + G + D ++ + + RP+ V A Sbjct: 233 GNAALEEVVMGLKHACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGL 292 Query: 287 VYSSFLRHCETAAARYGLSAVDI----LVELGKRRMVGGQEDMIVDVALD 332 L+ ++ L+ LGK G + + LD Sbjct: 293 HVDGVLKDPRNYEP---FEPHEVGSSRLLVLGKHTGRHGLAARVKGLGLD 339 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 119/355 (33%), Gaps = 42/355 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG +S E +A LD ++ IE Sbjct: 23 IEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVS-----------AD 71 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E ++ A+ +++I L D+ A + +V + ++ + Sbjct: 72 EKEIVKEIANQGFNSRICCL---SRAVKGDVDAALECDVDIVSIFIAMSDMHLKYKYHRS 128 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLME-GYGATCIYVVDSGG 170 + + I+YA + G+ + T E L + K +E Y + + D+ G Sbjct: 129 LEDMLGCAKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVG 188 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +N + + + H H +L + AN++AA E G ++ ++ +G Sbjct: 189 ILNPTTTNYLVSEIFKSVNTAICI--HCHDDLGMATANTLAAAEAGAKQLHTTVNAIGER 246 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP--LQD--RPVRVDRETLALGYAG 286 AGNA LE + A D L ++ + + V + Sbjct: 247 AGNASLEEVLVALRVQYGIERYDTTKLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGI 306 Query: 287 VYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L T G + +GK + +I + L + Sbjct: 307 HVAAILEEPRTYELFLPEMVGGKRNLV---VGKHTGKKALKGIINSIGFCLEREE 358 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 224 bits (570), Expect = 5e-57, Method: Composition-based stats. Identities = 70/372 (18%), Positives = 126/372 (33%), Gaps = 63/372 (16%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 I D TLRDG + ++ +IA LD+ V++IE G + Sbjct: 52 EIFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGFPITSNG-----------E 100 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD--------- 117 E ++ + +A I L D+ + + + Sbjct: 101 FEAVKKIKQLDLNATICGLSRCSN---KDIDAVIDCDLDRIHLFIATSPLHREYKLKKSK 157 Query: 118 -----VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 ++ I YA+E G+ + T + L + K I + D+ G + Sbjct: 158 EQILNKISESIIYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGIL 217 Query: 173 NMSDIRDRFRALKAELKPETQT---------------------GMHAHHNLSLGVANSIA 211 + + + LK+ L+ +H H++ L VANS++ Sbjct: 218 TPKKMENLIKDLKSGLETNKAINNSSTLTNQINIKSNMQMPVLSVHCHNDFGLAVANSLS 277 Query: 212 AVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL-GWQH---GTDLYALMDAADDLV-- 265 A E+G +I ++ G+G AGN L F+++ L G + L D + + Sbjct: 278 AFEQGVSQIHCTVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHY 337 Query: 266 --RPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQE 323 P+ V R A + + T +S D+ KRR+V G+ Sbjct: 338 TNIPIAPNKPLVGRNAFAHESGIHTHGVIANALTYEP---ISPFDVG---NKRRLVLGKH 391 Query: 324 DMIVDVALDLRN 335 + L L+ Sbjct: 392 AGAHSIKLKLQE 403 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 64/355 (18%), Positives = 123/355 (34%), Gaps = 42/355 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I+D TLRDG + + +IA+AL +A V +E Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPA-------------LG 64 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 + E + A + + ++ ++ ++ + G V ++ ++ Sbjct: 65 EEECVRLAI-LRRQLPDTVMMSWCRMNSAEIHDSARVGMDWVDISVPASDLLREQKLHRP 123 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 +Q A LGM + + E L A++ G + D+ G Sbjct: 124 WPAVIASLKPLVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGI 183 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ R AL+ +HAH++L + AN++AAV G ++ ++ G+G A Sbjct: 184 LDPFSTFTRISALRQHWHGG--LEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERA 241 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAG 286 GNA LE + D+ L G D L + R + + V + Sbjct: 242 GNAALESVTLSLDRCLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGL 301 Query: 287 VYSSFLRHCETAAARYGLSA----VDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ LR + G+ + + LGK + + L + Sbjct: 302 HVAALLRDPRSY---QGIDPSLVGREFNLVLGKHSGRQAVSGICARLGYILSETQ 353 >UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ Length = 379 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 58/354 (16%), Positives = 119/354 (33%), Gaps = 36/354 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + YI D TLRDG + + +IA+ LD+ VD IE Sbjct: 2 RDFYIVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAG-----------IPIMG 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS---- 119 + + I + AKI T D+ + GA+ + +A ++ + Sbjct: 51 EEEKDVIREIIAMNGKAKILT---WNRMKKMDVDASLACGAKYIHIAVPASDIHIFQKLR 107 Query: 120 ----------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + Y E G + + L + + GA + D+ Sbjct: 108 KDRKWVIQQVQEVVSYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTL 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + + + + + H H++ + ANS++A + G ID S+ G+G Sbjct: 168 GILTPITTYQAIKRICDYIDAD--LEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGE 225 Query: 230 GAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALGY 284 AGN LE + L H ++ +++ ++ + + + V + + Sbjct: 226 RAGNTALEEIVMTLKYLLKSNHPFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHES 285 Query: 285 AGVYSSFLRHCETAAA-RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L++ + G + LGK + ++ + + + Sbjct: 286 GIHVDGLLKNPTVYESFSPGEIGRKRKIVLGKHSGRTTVIYRLQEMGIKVTPKE 339 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 68/357 (19%), Positives = 123/357 (34%), Gaps = 40/357 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++++ D TLRDG + + +A+ L +A V IE Sbjct: 2 RQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETG-------------VP 48 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------- 115 A + E E A +VK + I DL+ + G R V + ++ Sbjct: 49 AMGEDEQ-ETIARIVKLNLPTRVTTWNRAVISDLEASLNCGVRSVAICLPSSDQQITQKL 107 Query: 116 -------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 D ++ A+ G+ V L + P+ L + E + + D+ Sbjct: 108 RQSRQWVLDQMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ + F L + L +HAH++L + AN+++A++ G ++ G+G Sbjct: 168 LGILDPIRTFNLFDRLTSSLS--IPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLG 225 Query: 229 AGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 AGNAPLE A +L L + RP+ V R+ Sbjct: 226 ERAGNAPLEEVALALRQCCAADTRINLALLPALCRLVSWSTRRPIPFSKPVVGRDAFTHA 285 Query: 284 YAGVYSSFLR---HCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + + + E Y I GK +++ DL + Sbjct: 286 SSIHVDGLNKDRSNYEAYPPEYVGRRHRI--AFGKYSGRKLLAELLKAQGHDLDQEE 340 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 219 bits (558), Expect = 1e-55, Method: Composition-based stats. Identities = 69/362 (19%), Positives = 108/362 (29%), Gaps = 49/362 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG A ++ IA L D VD IE + Sbjct: 5 ITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQT--------- 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGAR-VVRVATHCTEADV------ 118 E + A V L I A G + ++ + Sbjct: 56 --EAVTRIATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDK 113 Query: 119 ---------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 + + I+ A + + T PE L + + GAT I Sbjct: 114 LGNTMAEKREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTI 173 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPE--TQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + D+ G S+ D + L H H +L L AN++A + G +++ Sbjct: 174 NIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVE 233 Query: 222 ASLAGMGAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPV 273 ++ G+G AGNA LE + A D L + + P+Q Sbjct: 234 CTINGIGERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKA 293 Query: 274 RVDRETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDV 329 V + L T A G A I LG+ G + + + Sbjct: 294 IVGSNAFSHEAGIHQHGVLEERTTYEIMSATDVGQDAEQI--RLGRHSGRHGLFNRLEAM 351 Query: 330 AL 331 Sbjct: 352 GY 353 >UniRef50_UPI0001C34E31 hypothetical protein ClM62_09706 n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34E31 Length = 351 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 88/337 (26%), Positives = 150/337 (44%), Gaps = 6/337 (1%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N KK+ + D TLRDG + + +S E + L +V IE + G+ Sbjct: 17 NKKKIQLMDCTLRDGANVVGKGFSAEITDMVLDGLTSCKVPIIEFGNAGGIGAYEVAGFT 76 Query: 62 GAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 A +D E++E A + + ++I L + A + G +RV + ++ Sbjct: 77 NALTDSEYLEIAKKYLNRGSEIGMFLNAKRYREKYVDMAAENGLAFLRVGADAGDGSIAL 136 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 Q I ++ GM M +++ T + LA++ K +E G I ++DS G M + + Sbjct: 137 QAIADIKKRGMKAYYSAMKAYLLTADELAEEGKRLEEAGLDEITIMDSAGTMLPEQVAEY 196 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 R L + H H+NL L AN+IAA E G D +D L GM AGN P E+ Sbjct: 197 TRKLSEAVS--IPVAFHCHNNLGLSAANAIAAFENGADILDCGLMGMARSAGNLPTEICA 254 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDR---PVRVDRETLALGYAGVYSSFLRHCET 297 A +LG DLY ++ + + P ++ V + LGY+G +SSF++ + Sbjct: 255 AMMRRLGQMEEIDLYGMLSFIKNRLEPAMEKHSYHNPVKPLDVVLGYSGCHSSFVKTFQA 314 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLR 334 A G+ ++ E+ + ++++ A LR Sbjct: 315 VAEEKGVDLFRLICEVSEIDKKSPSKELMEQTADKLR 351 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 217 bits (554), Expect = 3e-55, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 126/350 (36%), Gaps = 34/350 (9%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 ++ D TLRDG A + + ++A+ L + +D IEV A + Sbjct: 6 FLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVG-------------IPAMGE 52 Query: 67 LEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA---------- 116 E ++V+ + + D++ A GA + +A ++ Sbjct: 53 DE-CNTIQNIVRLKLRPIISVWSRAIKKDIEQASTLGATCIHIAFPLSDIQLQAINKTYG 111 Query: 117 ---DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 D ++ IQ A+ L + + + + + E YG + D+ G + Sbjct: 112 WVEDTFSKTIQCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILT 171 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + R +K + K HAH++ + AN++ A + G + + ++ G+G AGN Sbjct: 172 PIQTIEIIRTIKKK-KTNMNIDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGN 230 Query: 234 APLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGVYS 289 A LE + ++ + DL L D + RPL D + ++ Sbjct: 231 AALEEILMGLRQINGKTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIHTQ 290 Query: 290 SFLRHCETAAARYG--LSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + L G L + GK D++ +++ ++ Sbjct: 291 AILSDILAFQPFNGDILGREKCSILFGKHSGKRAIIDLLKRQNIEVEESR 340 >UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY Length = 508 Score = 217 bits (552), Expect = 6e-55, Method: Composition-based stats. Identities = 64/348 (18%), Positives = 111/348 (31%), Gaps = 37/348 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + + + D TLRDG A + + IA++L+ A V IE G Sbjct: 13 RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAG--------- 63 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS---- 119 + + I D+ A++ + G D+ A V + ++ + Sbjct: 64 --ERQAISRVTDLELDARVTSF---CRGMESDIDLALDCDVDGVHIVVPASDRHIEDKVG 118 Query: 120 ----------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 A+ + YA++ + + L + GA I D+ Sbjct: 119 TSHEDNLEKTAELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTV 178 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + L H H +L LGVAN++AAV G D + ++ G+G Sbjct: 179 GHTGPERTAEAVGRL----ADVGPVSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGE 234 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 AGN LE A + +L L D A + R L + Sbjct: 235 RAGNVALEEVAIALSHVYDVETLELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESG 294 Query: 286 GVYSSFLRHCETAAARY-GLSAVDILVELGKRRMVGGQEDMIVDVALD 332 L+ + + + LGK G + + ++ Sbjct: 295 IHTDGTLKDDKMYEPYAPETVGRERRLALGKHTGRAGVTATLEEHGVE 342 >UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD Length = 531 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 64/355 (18%), Positives = 111/355 (31%), Gaps = 43/355 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + + D TLRDG A + +IA+ LD + ++ IE +G Sbjct: 22 TVQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEGER-------- 73 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS----- 119 E V AT+ G D++ A G V + ++ + Sbjct: 74 ------ETIRQVTGLDLDATVTSFARGVKSDIELAVDCGVDGVTIVVPASDQHIETKVGS 127 Query: 120 ---------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 A+ ++YA++ + E L + + GA D+ G Sbjct: 128 TRSEVVTTTAELVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVG 187 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 N + L A L P H H +L L + N ++ G D + ++ G+G Sbjct: 188 HANPETTYEYVSRL-AALGP---VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGER 243 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 AGN LE A L L A + + PL + Sbjct: 244 AGNVALEEVAIALAHGYDIETATLDQLYSLAQTVSQATNIPLPPNKAVIGENAFTHESGI 303 Query: 287 VYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L+ + G + LGK G + + + +D+ ++ Sbjct: 304 HTDGTLKDKTMYEPYSPSSVGRERRLV---LGKHAGRAGVQAALDEHRIDVSEDE 355 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 70/356 (19%), Positives = 125/356 (35%), Gaps = 38/356 (10%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLR+G ++++ +IAKAL D V IE H Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSP----------- 51 Query: 65 SDLEWIEAAADVVKHAKIAT-LLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 E I+ + K I + ++ D++ A + + + ++ + Sbjct: 52 DIYEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVNRIAIFYGVSDLHLKAKHK 111 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 A+ I YA+ G+ T + L +K GA + + D+ Sbjct: 112 ATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTV 171 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + S ++ F AL E+ P + +HAH++L L VAN++AA+E G I A++ G+G Sbjct: 172 GILYPSKTKELFSALTREV-PNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGE 230 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYA 285 G PL+ AA L L + + + P+ Sbjct: 231 RVGIVPLQQIAAAIKYHFGIEVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAG 290 Query: 286 GVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + L T +G + K D + + + + + Sbjct: 291 VHVAGVLNDPRTYEFMPPETFG---RTRDYTIDKYTGKHALRDKYEKLGVKISDAE 343 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 214 bits (545), Expect = 4e-54, Method: Composition-based stats. Identities = 72/360 (20%), Positives = 122/360 (33%), Gaps = 42/360 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +L I D TLRDG A + +IA+ L+ RVD+IE G Sbjct: 13 QPDRLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFAAASPG------- 65 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEADVSA 120 D E I A ++++ + +L G I A + A + + + + A Sbjct: 66 ----DSEAIRLIASEIRNSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREA 121 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + +++A + + T P+ L + GA + V Sbjct: 122 KLRMSRREVLQTIERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVP 181 Query: 167 DSGGAMNMSDIRDRFRALKAEL--KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G +IR F L A + H H++L L V+NS+AAV+ G +++ ++ Sbjct: 182 DTVGYSEPDEIRAVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAI 241 Query: 225 AGMGAGAGNAPLEVFIAAADK----LGWQHGTDLYALMDAADDLVR----PLQDRPVRVD 276 G+G AGN LE + A D + A+ L R + V Sbjct: 242 NGIGERAGNCSLEEIVMALQVRADIFPAISHVDATKIWSASQRLARVTGSAVAPNKAIVG 301 Query: 277 RETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 + A + T G ++ LGK + + Sbjct: 302 KNAFAHEAGIHQHGMISDRRTYEIMTPESVGAPGSALV--LGKHSGKHALVQRLAKLGYQ 359 >UniRef50_A5U8E4 4-hydroxy-2-oxovalerate aldolase MhpE n=10 Tax=Mycobacterium tuberculosis complex RepID=A5U8E4_MYCTA Length = 336 Score = 213 bits (543), Expect = 7e-54, Method: Composition-based stats. Identities = 93/312 (29%), Positives = 159/312 (50%), Gaps = 4/312 (1%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + G++ G A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTI-GAAAAQGPAA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 H+D E+ AA VV++A++ +++P + I + A +R+ TE ++ + Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDY-LDFLRICVIATEFELVMPFV 125 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R A Sbjct: 126 ERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA 185 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +AA Sbjct: 186 LRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAAL 243 Query: 244 DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYG 303 + G DL + DAA + + +D ++ G+ G+ S + H AA + G Sbjct: 244 QRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAG 303 Query: 304 LSAVDILVELGK 315 LS ++ + K Sbjct: 304 LSVSHVIRQTAK 315 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 213 bits (542), Expect = 7e-54, Method: Composition-based stats. Identities = 69/356 (19%), Positives = 118/356 (33%), Gaps = 40/356 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + SD TLRDG QIAKAL+ A V S++ Q Sbjct: 30 VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGFPASSQA----------- 78 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA---GARVVRVATHCTEAD----- 117 D++ I++ V+K + L G + A R V + + Sbjct: 79 DIDAIQSMVGVIKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKL 138 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + IQYA E + T + L + + GAT I D+ Sbjct: 139 EKSKSEVLKLIVDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDT 198 Query: 169 GGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G + +D ++ E+ +H H++L L VAN++A ++ G + + ++ G Sbjct: 199 VGILTPWKAQDFICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNG 258 Query: 227 MGAGAGNAPLEVFIAAADKLGWQ----HGTDLYALMDAADDLVR----PLQDRPVRVDRE 278 +G AGNA LE A + H D+ L + L Sbjct: 259 IGERAGNAALEEVAMALHLHQEEYQRPHQLDVSQLAPLCKLVAELTGIALSPMKPVAGSN 318 Query: 279 TLALGYAGVYSSFLRHCETAAA--RYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 A L++ +T + I + LG+ + ++ + Sbjct: 319 IFATEAGIHQDGLLKNPDTYLPYRPETVGETGIRLVLGRHSGRKAILHRLHELGKE 374 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 213 bits (542), Expect = 8e-54, Method: Composition-based stats. Identities = 68/351 (19%), Positives = 134/351 (38%), Gaps = 25/351 (7%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+YI D TLRDG +SLE+ +IA+ LDD + IE + + Sbjct: 2 AEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQKA 61 Query: 63 AHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC 113 + + + A V + ++ +L+ + +W T Sbjct: 62 KKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTLE 121 Query: 114 TEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 ++ + ++Y + + + + + PE + + GA + + D+ G Sbjct: 122 ENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTNG 181 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +I + + +K + G+HAH++ VANS+ AV G ++ ++ G+G Sbjct: 182 GTLPHEIYEITKKVKERF-KDANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGER 240 Query: 231 AGNAPLEVFIAAAD-KLGWQ--HGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 GNA L I KLG+ +L L + A+ + PL V A Sbjct: 241 TGNANLCSIIPNLQLKLGFDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESAFAHK 300 Query: 284 YAGVYSSFLRHCETA----AARYGLSAVDILVEL-GKRRMVGGQEDMIVDV 329 S+ L++ +T G + +L G+ +V ++ +++ Sbjct: 301 GGVHASAVLKNAKTYEHINPELVGNKRKITVSDLAGRSNLVHKLKEFGIEI 351 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 122/350 (34%), Gaps = 41/350 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG + R +S + R+IA LDD IE Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDA----------- 58 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 + E + A + + L D+ A +G +V V ++ + Sbjct: 59 EFEAVSDIAAAT-NTTVCGL---ARVVEGDIDAAIDSGVEMVHVFVSTSDVQLEDSMHAT 114 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++ ++ G++ + M + T P+ L + + + G I + D+ G Sbjct: 115 RQEAKQRAVAAVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGV 174 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + +A+ + + +H H + + AN++ E G ++ S+ G+G A Sbjct: 175 AMPTSFGKTVKAVVNA--TDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERA 232 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 GNA E + A + G G D + A + P+ R A Sbjct: 233 GNAAYEEVVMAVESVYGVDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGI 292 Query: 287 VYSSFLRHCETAAARYGLSAVDILVE----LGKRRMVGGQEDMIVDVALD 332 + + + +T ++ + E LGK +V+ D Sbjct: 293 HAAGVIENADTFETGV-MTPEMVGAEREFVLGKHTGTHSVRKHLVEAGFD 341 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 119/334 (35%), Gaps = 41/334 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L +SD TLRDG ++S+++ IAKAL DA V IE G + Sbjct: 17 LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSER----------- 65 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA---RVVRVATHCTEAD----- 117 ++E + V +I L G I A A R V + + Sbjct: 66 EIEAVRRICAEVPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHKL 125 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + + YAR+ + T P L + + GAT I D+ Sbjct: 126 GKSKAQCLDMIGRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDT 185 Query: 169 GGAMNMSDIRDRFRALKA-ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + +R R R L A + +H H++L L AN++AAV G D + ++ G+ Sbjct: 186 LGVLTPEAVRRRVRMLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGI 245 Query: 228 GAGAGNAPLEVFIAAA----DKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRET 279 G AGNA LE + A + G D L + R PL V Sbjct: 246 GERAGNAALEETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANI 305 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAVDI 309 A L+H +T G + + Sbjct: 306 FATSAGVHQDGLLKHPDTYLPFRPEAVGADGIRL 339 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 210 bits (535), Expect = 6e-53, Method: Composition-based stats. Identities = 79/359 (22%), Positives = 133/359 (37%), Gaps = 43/359 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 + K L I+D TLRDG A ++L IAKALD+A VD IE Sbjct: 5 SDKHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAGIPAMGASE------ 58 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 IEA +V+ ++ A ++ I D+ A + GA+ V ++ + ++A+ Sbjct: 59 --------IEAIRQIVQQSQTARVIPWCRMKISDVDKALETGAKTVHLSISSSPFQMAAK 110 Query: 122 ---------------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 I YA++ G+D + L ++E GA I Sbjct: 111 FPDLSAADILGLCQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFA 170 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G ++ + L + H H +L L ANS+AA++ G ++ G Sbjct: 171 DTLGILDPFATYEIISQLHQISPLD--IEFHGHDDLGLATANSLAAIKAGAKGASVTVLG 228 Query: 227 MGAGAGNAPLEVFI-AAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLA 281 +G AGNAPLE + AA+ G + L + A + R + V Sbjct: 229 LGERAGNAPLEQVVIAASHIAGKETRILPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQ 288 Query: 282 LGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + LR+ + + G + LGK + + + + + Sbjct: 289 HESGIHVAGLLRNPASYEALNPEKLG---RQREIVLGKHSGRAAIRHALSLLGIKAQED 344 >UniRef50_B0TEI2 Oxaloacetate decarboxylase, alpha subunit n=27 Tax=cellular organisms RepID=B0TEI2_HELMI Length = 643 Score = 210 bits (534), Expect = 8e-53, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 118/336 (35%), Gaps = 23/336 (6%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I++ TLRDG ++ + LE++ I + +D S+EV G Sbjct: 5 RRVKITETTLRDGHQSLWATRMRLEDMLPIVEKMDKVGYHSVEVWGGATFDVCMRYLN-- 62 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E + + + LL P + A + G ++R+ Sbjct: 63 -EDPWERLRILKKYFRRTPLQMLLRGQSLVGYTHYPDDVVEAFVHKAVENGIDIIRIFDA 121 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + +++A++ G ++ S + T E+ + A + GA + + D G Sbjct: 122 LNDIRNMEAPMRHAKKAGAHVQAAIVYTISPVHTMEHYVETALQLAEMGADSLCIKDMAG 181 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + R+ +K ++ +H H+ + V + VE G D ID + + G Sbjct: 182 LLLPFKSRELVTLIKEKV--NLPLQLHTHYIGGMAVGALLKGVEAGADIIDCASLPLAFG 239 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV---RPLQDRPVRVDRETLALGYAGV 287 P+E + A + G D++ + + + L + + + V Sbjct: 240 PSQPPVETLVRAFSDTPYDPGLDIHRIFEITQYFEDLRKRLGYKRGITGLNDMLVFDHQV 299 Query: 288 YSSFLRHCETAAARYGLSAV--DILVELGKRRMVGG 321 + + T D+L E+ K R G Sbjct: 300 PGGMITNLITQLEEQKARHRLNDVLHEMPKVRADFG 335 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 209 bits (532), Expect = 1e-52, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 124/351 (35%), Gaps = 32/351 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLR+G +S++ +IA+AL DA V IE H + Sbjct: 2 IGLLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETV---------- 51 Query: 66 DLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD------- 117 L+ I++ ++ I +T++ D+ A ++ + ++ Sbjct: 52 -LKSIKSIMELKSSGIIRSTIVAHSRAVRSDIDVAASLNIDMIAIFYGISDLHLKYKTLK 110 Query: 118 -------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + I YAR G++ + T L A+ GA I + D+ G Sbjct: 111 TREDAIRIIVDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVG 170 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +N F+ + ++ + +HAH++L + VANSIAA G I +++ G+G Sbjct: 171 ILNPDTSYKLFKMIIKDV-KNVEFDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGER 229 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALGYAG 286 +G P ++ A + DL L ++ + + + + Sbjct: 230 SGITPTQIIGPALKYHYNEAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGV 289 Query: 287 VYSSFLRHCETAAARYG-LSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + + ET L + + ++ + L + Sbjct: 290 HIAGIINKPETYEFMDPCLFGNKRYYTISSYSGRHAVITRLQELGISLNDE 340 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 66/356 (18%), Positives = 113/356 (31%), Gaps = 32/356 (8%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDGM ++++ ++A+ LDD V IE + A Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAA 61 Query: 64 HSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 D + A V K I LL G + + W V T + Sbjct: 62 KIDFKNARLTAFGSTRRAGLAVEKDDNIRLLLECGAPAVALVGKTWDLHITEVMSNTLES 121 Query: 115 EADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 ++ + Y + G + E K GA + + D+ G Sbjct: 122 NLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQAGADAVILCDTNGG 181 Query: 172 MNMSDIRDRFRALKAELKPE---------TQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 D+ + L Q G+H H++ +L VANSIAA+ G + Sbjct: 182 ALPHDVEAITAEVCTTLADRFPGPDGGSTVQVGIHTHNDSNLAVANSIAAIRAGARIVQG 241 Query: 223 SLAGMGAGAGNAPLEVFIAAA---DKLGWQHGTDLYALMDAADDLVRPL---QDRPVRVD 276 ++ G G GNA L I + +L L + + Sbjct: 242 TINGYGERCGNADLTSIIPILAAKMEYDCITPENLKKLRKVSRFVSETANMTPVNSRPFV 301 Query: 277 RETLALGYAGVYSSFLRHCETA-----AARYGLSAVDILVELGKRRMVGGQEDMIV 327 ++ G++ S + A G ++ +L R V + + Sbjct: 302 GKSAFSHKGGLHVSAIMKNPRAYEHMDPELVGNKRRVLISDLSGRSNVTYKARELG 357 >UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI Length = 418 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 69/359 (19%), Positives = 122/359 (33%), Gaps = 44/359 (12%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ +SD TLRDG E R+IA AL+ A + S++ Q Sbjct: 28 RIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGFPASSQQ---------- 77 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQA---GARVVRVATHCTEAD---- 117 D + I A V+K + L G + A R V + + Sbjct: 78 -DFDAIRLMAQVIKRPVMTALCRTVEGDVDAADEALAGLAPHKRGVSLFIGTSPLHREYK 136 Query: 118 ----------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + ++YA + + T + L + + GAT I D Sbjct: 137 LRKSRTEVLSIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPD 196 Query: 168 SGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + R + + + +H H++L L VANS+A + G + ++ Sbjct: 197 TVGVLTPERAYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVN 256 Query: 226 GMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDR 277 G+G AGNA LE A + G + +L + + P+ R Sbjct: 257 GIGERAGNAALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGR 316 Query: 278 ETLALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 A L+H +T G A++++ LG+ G + ++ Sbjct: 317 TIFATEAGIHQDGLLKHPDTYLPYRPEVVGGPAIELV--LGRHSGKGAVAHHLQNLGYQ 373 >UniRef50_C5A1I6 Pyruvate carboxylase subunit B (PycB) n=18 Tax=Archaea RepID=C5A1I6_THEGJ Length = 595 Score = 207 bits (528), Expect = 4e-52, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 122/339 (35%), Gaps = 30/339 (8%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ I D T RD ++ + + +++ +IA+ +D S+EV G + Sbjct: 3 KVDIIDTTFRDAHQSLIATRLTTDDMLKIAETMDRIGFYSMEVWGGATFD---VCIRYLK 59 Query: 64 HSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATHC 113 E + + ++ K+ LL P ++ A + G + R+ Sbjct: 60 EDPWERLRLLREHIRKTKLQMLLRGQNVVGYKHYPDDVVEKFVELAHKNGIDIFRIFDAL 119 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMSHM--TTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + I+ A+E+G + G + + T E K+ + + I + D G Sbjct: 120 NDVRNMEVAIRKAKEVGAEVQGAIAYTTGKVFTLEYYMKKVEELLKLDVDVITIKDMAGL 179 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + I + +K +H H + VA + VE G D ID +++ + G Sbjct: 180 LTPWKIYELVSEIKETYG--IPVNVHTHSTTGMAVAVYLKGVEAGADYIDTAISPLAFGT 237 Query: 232 GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR-------VDRETLALGY 284 ++ A + H D + + L + L+++ + + Sbjct: 238 AQPGIQTIWHALPEAVGSH-LDRELIHRVSRYLKKLLEEKYWGLLHKETLIVNPYVLKYQ 296 Query: 285 --AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G++S+ + + A L ++L E+ + R G Sbjct: 297 VPGGMFSNLIAQLKEMNALDRLD--EVLEEIPRVREDLG 333 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 207 bits (527), Expect = 4e-52, Method: Composition-based stats. Identities = 66/360 (18%), Positives = 129/360 (35%), Gaps = 37/360 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ D T+RDG I ++++ ++A+AL+ V +IE + Sbjct: 8 TNQITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGFPAASKK-------- 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEADVSAQ 121 D + + + VV AK+ L I + A Q A ++ V + + + Sbjct: 60 ---DFDAVVEISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYK 116 Query: 122 H--------------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 I+Y + + + + + T PE LA+ + GAT I + D Sbjct: 117 LHMSPSEIIEKVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPD 176 Query: 168 SGGAMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 + G + + F L+ ++ + H H++L + AN++A + G I ++ Sbjct: 177 TVGYATPYEYGELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTIN 236 Query: 226 GMGAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDR 277 G+G AGN + AA Q L +D + P+ + R Sbjct: 237 GIGERAGNVDIIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGR 296 Query: 278 ETLALGYAGVYSSFLRHCETAAA-RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A +L++ ET R + + LGK + ++ + + Sbjct: 297 NAFAHESGIHQDGYLKNPETYEILRPEMVGTQASLPLGKLSGSHAVMNQLLSLGYHISRQ 356 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 207 bits (527), Expect = 4e-52, Method: Composition-based stats. Identities = 67/348 (19%), Positives = 116/348 (33%), Gaps = 48/348 (13%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 + K + + D TLRDG ++L + +IA LD+ V+ IE Sbjct: 29 SKKSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPK------- 81 Query: 62 GAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIH-------------------DLKNAWQ 101 D E+ + + A+IA + +W Sbjct: 82 ----DEEFFKEIKKYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIFGKSWS 137 Query: 102 AGARVVRVATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGY 158 A V T D+ I Y R G+ + P+ + K E Sbjct: 138 LHATEVLKVTKQDNLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYALEVVKTAESA 197 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 GA I + D+ G ++ + + ++ L + G+HAH+++ VANS+ A++ G Sbjct: 198 GADVIALADTNGGTPPFEVYEITKKVREVL--HVKLGIHAHNDIGCAVANSLMAIKAGAR 255 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAA---DKLGWQHGTD-LYALMDAADDLVRPL---QDR 271 + ++ G+G GNA L I G D L L + + + L + Sbjct: 256 HVQGTINGIGERTGNADLIQIIPTLVLKMGFNVLKGRDSLRKLREVSRIVYEILGLPPNP 315 Query: 272 PVRVDRETLALGYAGVYSSFLRHCETA-----AARYGLSAVDILVELG 314 + AGV+ + A G ++ EL Sbjct: 316 YQPYVGDNAFAHKAGVHVDAVMKVPRAYEHVDPLLVGNDRKFVISELS 363 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 207 bits (527), Expect = 4e-52, Method: Composition-based stats. Identities = 76/358 (21%), Positives = 126/358 (35%), Gaps = 42/358 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + +++D TLRDG A ++ +IA+AL A V IE Sbjct: 30 ARTAFLNDTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGTPAMG---------- 79 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV---- 118 E IE +V + + DL A AG V ++ ++ + Sbjct: 80 ----DEEIETLRSIVSLKLPLRVAAWCRMSEEDLFAAVSAGVTYVNLSIPTSDRQLKGKL 135 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + A +LG + P+ L K A++ + GA + + D+ Sbjct: 136 NRDRDWALGALRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADT 195 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G ++ R + + + HAH +L L AN++AAV G ++AG+G Sbjct: 196 LGVLDPFSAYALVRRVANA--TDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLG 253 Query: 229 AGAGNAPLEVFIAAADKLGW-QHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 AGNA LE A + + G D +AL A ++ RP+ V + Sbjct: 254 ERAGNAALEEVAIALRQTARSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHE 313 Query: 284 YAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 S L+ T G S + LGK + + D L + + Sbjct: 314 SGIHVSGLLKDRGTYEALSPEMLGRSHRVV---LGKHSGLAAILKALSDQGLAVDEAR 368 >UniRef50_Q7NM88 Oxaloacetate decarboxylase alpha chain n=1 Tax=Gloeobacter violaceus RepID=Q7NM88_GLOVI Length = 508 Score = 207 bits (527), Expect = 4e-52, Method: Composition-based stats. Identities = 53/340 (15%), Positives = 120/340 (35%), Gaps = 25/340 (7%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 + ++ ++D T RD ++ + + + +A ++ S+EV G G Sbjct: 18 STSRVGVTDTTFRDAHQSLLATRMTTAQMLPVASRMNRIGFHSMEVWGGATFDACIRFLG 77 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 E ++ + ++ L+ P ++ + G ++R Sbjct: 78 ---EDPWERLKVLRREMPDTRLQMLVRGQNLLGYRHYPDDIVERFIRRSVANGIDIIRTF 134 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + I+ +E G G L+ S + ++ A+ + G + + D Sbjct: 135 DALNDVRNMRKTIETGKECGAHVQGTLVYTVSPVHDVDHYMAVARDLVAMGIDSLCIKDM 194 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + RAL+ + MHAH + A++ G + +D +++ + Sbjct: 195 AGLLKPDAAGRLVRALRPVVGTLLPIQMHAHSLSGMASMAYWEAIQMGANAVDTAISPLA 254 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ-----DRPVRVDRETLALG 283 G+ E + + G D+ AL+D A+ + R + + + Sbjct: 255 LGSSQPATETMVVVLRDTPFDTGLDIDALVDVAESIERIFRDAGNAPIRQTIIDTRVLSH 314 Query: 284 Y--AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ ++ L + A + L ++L EL + R G Sbjct: 315 QVPGGMITNLLAQLDQQRASHRL--QEVLRELPRVRADFG 352 >UniRef50_Q8KT71 MhpE-like protein n=4 Tax=Proteobacteria RepID=Q8KT71_PHOLU Length = 312 Score = 207 bits (527), Expect = 5e-52, Method: Composition-based stats. Identities = 70/256 (27%), Positives = 111/256 (43%), Gaps = 2/256 (0%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 DVTLRDG + ++ E + +AL + V+ E+ + +G N G S Sbjct: 5 IDVTLRDGGYLNNFNFTTEYAIKHVEALTKSGVEWFEIGYRNGSFKPISNIGLTGMSPDS 64 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARE 128 +I V AK+ + P D+ G ++R+ + + AR Sbjct: 65 YIRDIHQSVPEAKLVVIAHPHNINADDIYAMKTNGVSLLRLCIKADNPQPCLELCEIARA 124 Query: 129 LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAEL 188 GM + + + + AK E GA IY+ DS G++ + F LK+ Sbjct: 125 TGMAVGINFTRASQLSISKIIEIAKQCEQAGADIIYLADSNGSLFPEQVAQMFYKLKSA- 183 Query: 189 KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGW 248 + Q G H H NL L ANSI A+ G + ID+SL+GMG GAGN LE +++ + Sbjct: 184 -TQVQLGFHPHDNLGLATANSIEAMRAGVNFIDSSLSGMGKGAGNLNLESWLSFLNLSQN 242 Query: 249 QHGTDLYALMDAADDL 264 DL + + ++L Sbjct: 243 SKQYDLERVFNQLNEL 258 >UniRef50_Q1IM73 Conserved carboxylase region n=7 Tax=Bacteria RepID=Q1IM73_ACIBL Length = 520 Score = 207 bits (526), Expect = 5e-52, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 125/341 (36%), Gaps = 27/341 (7%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 G+ + ++D+ LRD ++ + ++E++ + LD+A S+E G F Sbjct: 19 GRIIEVTDLILRDAHQSLMATRMAMEDMVPACEDLDNAGYWSLECWGGATFDSC---IRF 75 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 E + ++ K+ LL + A + G V RV Sbjct: 76 LNEDPWERLRQFKKLLPKTKLQMLLRGQNLLGYRHYEDSVVERFVAKAAENGMDVFRVFD 135 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + I+ ++ G G + S + T + AK ++ G I + D Sbjct: 136 ALNDIRNLQTSIKAVKKTGKHAQGTISYTISPVHTITAFVEMAKQLKEMGCDSICIKDMA 195 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + D + +K + +H H + + + + AVE GCD +D +++ M Sbjct: 196 GLLKPQPAYDLVKGIKEACGDDMLVHVHCHATTGVTLVSLMKAVEAGCDMVDTAISAMCL 255 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY----- 284 G G+ P E F+ + G++ D+ ++ A ++ R + + Sbjct: 256 GPGHNPTESFVEMLEGTGFETKLDMARILK-ARRYFEKIRPRYKEFLSDITGVETEIFKS 314 Query: 285 ---AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 G+ S+ + A L ++L+E+ R G Sbjct: 315 QIPGGMISNMESQLKGQGAGDKL--QEVLLEVPNVRKDSGF 353 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 206 bits (525), Expect = 7e-52, Method: Composition-based stats. Identities = 60/348 (17%), Positives = 120/348 (34%), Gaps = 41/348 (11%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 I D TLRDG +S + I K LD V IE ++ Sbjct: 3 IDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAG-----------IPVMGLAES 51 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------------ 115 E+ ++ A+I I D++ + AGA + ++ ++ Sbjct: 52 RMFESIMELGLDARIIA---WNRALIGDVQASIAAGANSIEISLPMSDVQINTKLNKTRG 108 Query: 116 --ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 D + + + + + LA+ + +E +GA D+ G ++ Sbjct: 109 WILDQVKSVLDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGILD 168 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + ++ + + H H++ + AN++AAV G ++ ++ G+G AGN Sbjct: 169 PFKTYELTAKIREITSMDIEI--HTHNDFGMATANALAAVRAGATHVNTTVIGLGERAGN 226 Query: 234 APLEVFIAA-ADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGVY 288 APLE I A G D + ++ + R L + + Sbjct: 227 APLEEIIMASRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIHT 286 Query: 289 SSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L++ + A ++ ++ R +V G + + + L Sbjct: 287 DGVLKNPKNYEA---FDPAELNMQ---RNLVFGNQSGLAVLKYILEQE 328 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 206 bits (525), Expect = 7e-52, Method: Composition-based stats. Identities = 76/362 (20%), Positives = 115/362 (31%), Gaps = 43/362 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 L ISD TLRDG +S+ + IA+AL+ A VD IE G G Sbjct: 10 LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAG----------- 58 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ---AGARVVRVATHCTEAD----- 117 ++E + A I L + A A R V V + Sbjct: 59 EIEAVRQVAAATARPLIMALCRAVDADVDAAWQALGDAPAERRGVGVFLATSPLHRRHKL 118 Query: 118 ---------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + A + YAR+ T P L + GAT I D+ Sbjct: 119 GKTKAQCLAMIASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDT 178 Query: 169 GGAMNMSDIRDRFRALKA-ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + R R L + H H++L L AN++AA+ G D + ++ G+ Sbjct: 179 VGVLTPETARRRIAMLVRLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGI 238 Query: 228 GAGAGNAPLEVFIAAADKLGWQH----GTDLYALMDAADDLVRP----LQDRPVRVDRET 279 G AGNA LE + A Q+ D L + + L Sbjct: 239 GERAGNAALEETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANV 298 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 A L+H +T G + + L ++ + L Sbjct: 299 FATAAGVHQDGLLKHPDTYLPFRPELVGAEGIRL--PLSPLSGKAALALRYTELGIALSA 356 Query: 336 NK 337 ++ Sbjct: 357 DE 358 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 206 bits (525), Expect = 7e-52, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 122/351 (34%), Gaps = 26/351 (7%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+ I D TLRDG S+E+ +IA LD VD IE + Sbjct: 2 AEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLRA 61 Query: 63 AHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC 113 A + A + + G+ +W T Sbjct: 62 REVIWRQARLVAFGRTRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLHVTAALGTTLA 121 Query: 114 TEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + + + G++ + P+ + K GA+ I + D+ G Sbjct: 122 ENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYALETLKAAAKAGASWIVLCDTNG 181 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +I + ++ E+ + G+HAH++ L VAN++AAV GC ++ ++ G G Sbjct: 182 GCLPWEIEEAVARVRQEI--QVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGFGER 239 Query: 231 AGNAPLEVFIAAAD-KLGWQHGT--DLYALMDAADDLVRP---LQDRPVRVDRETLALGY 284 GNA L + + K+G+Q L L + + + + + Sbjct: 240 CGNADLCSVMPNLELKMGYQCLPPGQLAFLTEVSRYVSEIANVVPAGNQPFVGYSAFAHK 299 Query: 285 AGVYSSFLRHCET-----AAARYGLSAVDILV-ELGKRRMVGGQEDMIVDV 329 G++ S + + G ++ + G + E+M +++ Sbjct: 300 GGIHVSAVLKAPDTYEHIRPQQVGNERRVLMSDQAGASNLRCKAEEMGLEL 350 >UniRef50_C5VE99 Pyruvate carboxylase subunit B n=3 Tax=Corynebacterium RepID=C5VE99_9CORY Length = 516 Score = 206 bits (525), Expect = 8e-52, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 132/342 (38%), Gaps = 28/342 (8%) Query: 1 MNGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M+ +K+ +++V LRD ++ + +LE++ +D A S+E G++F+ Sbjct: 24 MSPRKIGVTEVALRDAHQSLFATRMALEDMVAACDDIDKAGFWSVEC-----WGGATFDA 78 Query: 60 GFGAHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVV 107 ++ W + +++ ++++ LL + ++ + + G V Sbjct: 79 CIRFLNEDPWKRLRTFRELMPNSRLQMLLRGQNLLGYRHYEDMVVDKFVEKSKENGMDVF 138 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYV 165 RV + + + +++G G + S + + K A + GA I + Sbjct: 139 RVFDALNDPRNLERAMTAVKKVGGHAQGTICYTVSPLHDVDGYIKLAGQLLDMGADSIAL 198 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D + D R +K + Q +H H + + + A+E G D +D +++ Sbjct: 199 KDMAALLKPQPAYDIIRGVKDTYGDDVQINVHCHSTTGVTLVTLMKAIEAGADVVDTAIS 258 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL------VRPLQDRPVRVDRET 279 + G G+ P E + + G+ D+ L+ D R + + + Sbjct: 259 SLSLGPGHNPTESLVEMLEGTGYTADLDMDRLIKIRDHFKTIRPKYREFESKTLVDTNIF 318 Query: 280 LALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 L+ G+ S+ + A + +++ E+ + R G Sbjct: 319 LSQIPGGMLSNMESQLQAQGAGDRID--EVMEEVPRVRAAAG 358 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 206 bits (524), Expect = 9e-52, Method: Composition-based stats. Identities = 58/357 (16%), Positives = 119/357 (33%), Gaps = 40/357 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + ++I D TLRDG A ++ E + IA L + V+ +E+ + Sbjct: 12 KRPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYPAISSEEQ------ 65 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 ++ + L D+ A + + V ++ +E Sbjct: 66 --------AVITEIARMQLPLRLTSWARAKWEDIDAAIRCKTQGVHISFPLSELYLQLMD 117 Query: 117 -------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + A++ + T P+ L + + GA I + D+ Sbjct: 118 KPYEWVEEQLHLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTV 177 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + +K + HAH++L + AN+ +A+E GCD + S+ G+G Sbjct: 178 GIATPLHLMQLISRIKKAVP--ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGE 235 Query: 230 GAGNAPLEVFIAAADKLGWQH-GTDLYALMDAADDLVRP----LQDRPVRVDRETLALGY 284 AGNA LE A G H L + + + ++D+ + Sbjct: 236 RAGNAALEELAIALKLSGRYHSSIKTERLQELCGIVAKASNRNIEDQKPVIGASVFRHES 295 Query: 285 AGV----YSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + L + G +++ +GK + ++ + + + Sbjct: 296 GIHCNALLKNPLSYQPFLPGEIGRDNYELV--IGKHSGSAAIQHVLAGNGIAIDRKE 350 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 206 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 57/320 (17%), Positives = 107/320 (33%), Gaps = 35/320 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 KK+ I D TLRDG A + E ++A L++ VD IE + Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKF--------- 52 Query: 64 HSDLEWIEAAADVVKHAKIATLLLP------------GIGTIHDLKNA---WQAGARVVR 108 D E + + V + IAT G H ++ + R Sbjct: 53 --DYEATKLISKEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKR 110 Query: 109 VATHCTEADVSAQHIQYAREL-GMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + +++A++ + + + + + + GA I + D Sbjct: 111 NISRSQAIEEVINTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILAD 170 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G S+ + + ++++ H H++L L AN++A +E G D + +L G+ Sbjct: 171 TTGYATPSEFKKLIQFIRSKTGDGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGI 230 Query: 228 GAGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRET 279 G AGNA LE+ + L L +L + Sbjct: 231 GERAGNASLEMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIGLDIPRNQPVFGTYA 290 Query: 280 LALGYAGVYSSFLRHCETAA 299 + L + +T Sbjct: 291 FSTAAGIHQQGVLANPDTYE 310 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 206 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 112/290 (38%), Gaps = 31/290 (10%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I D TLRDG + +S + +IA+ LD V+ IE+ Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIELGIPAMGGI---------- 52 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA-------- 116 +++ I + A + A++ T + D++ + + + + ++ Sbjct: 53 -EVDAISSIASLDLKARLTT---WNRLHLSDIRASLSCRVKNLHICAPVSDIQIEYKLNK 108 Query: 117 ------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 D + I+YA++ G + PE L + A L + GA + D+ G Sbjct: 109 SRLWVLDCLKRAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVG 168 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + LK +LK + H H++ L AN++AAV G ID ++ G+G Sbjct: 169 VLEPFSTYRELSWLKDKLK--IELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGER 226 Query: 231 AGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRET 279 AGNA +E +AA G + + + R + + + Sbjct: 227 AGNANMEEVVAAIRMSCGIGMNWANDKMKALSSYVARASNRKMPKTFHDF 276 >UniRef50_Q2RIA5 Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=15 Tax=Bacteria RepID=Q2RIA5_MOOTA Length = 643 Score = 206 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 122/337 (36%), Gaps = 27/337 (8%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +L I+D TLRDG ++ + + ++ I + +D S+EV G Sbjct: 29 QLKITDTTLRDGHQSLWATRMTTADMLPIIEKIDSVGYHSLEVWGGATFDVCMRFLD--- 85 Query: 64 HSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATHC 113 E + + + LL P + A G ++R+ Sbjct: 86 EDPWERLRTLKKYARRTPLQMLLRAQSLVGYQLYPDDVVRAFIARAAANGIDIIRIFDAL 145 Query: 114 TEADVSAQHIQYARELGMDTVGF--LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++ A++ G+ G +S + T E+ K A +E G I + D G Sbjct: 146 NDLRNMEVPVEAAKKEGVHVQGTVVYTISPVHTTEHYLKTALELESMGVDSICIKDMAGL 205 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + + K +L +H+H+ L V + A G D +D + + GA Sbjct: 206 LAPFEAYKLVKLFKEKL--HVPVQLHSHYIGGLAVGAYLEAARAGVDVVDTASVPLAFGA 263 Query: 232 GNAPLEVFIAAADKLGWQHGTDLYALMDAADDL--VRPLQDRPVRVDRETLALGY----- 284 P+E + A + + G DL L + A +R V R T + Sbjct: 264 SQPPVETVVRALEGTPYDTGLDLNLLFEIARYFDDLRRELGYERGVTRITDMWVFQHQVP 323 Query: 285 AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + + A ++ ++L E+ + R G Sbjct: 324 GGMISNLVSQLKEQKAADRIN--EVLAEIPRVRADLG 358 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 71/384 (18%), Positives = 126/384 (32%), Gaps = 63/384 (16%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 NGK + I D TLRDG ++L+ IA LDD V+ IE Sbjct: 7 NGKTIEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPK------- 59 Query: 62 GAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIHD-------------------LKNAWQ 101 DLE+ + ++++KIA I + Sbjct: 60 ----DLEFFKLIKKHELRNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSS 115 Query: 102 AGARVVRVATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGY 158 + + ++ + + RE G+ T + PE + K E Sbjct: 116 FHVEKILNCSLEDNLEMIYDSLIFLRESGLQTYFDAEHFFDGYNINPEYAIQTVKTAEEA 175 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 I + D+ G M I + +K E + G H H++ VAN+++AV G Sbjct: 176 KVNTIVLCDTNGGMLPHQIERVVKKIKKN--SEVKIGFHGHNDTGCAVANTVSAVVAGAT 233 Query: 219 RIDASLAGMGAGAGNAPLEVFIAAA-DKLGWQHG-------TDLYALMDAADDLVRPLQD 270 I ++ G+G GNA L I KL + + L D ++ + + Sbjct: 234 HIQGTINGLGERTGNADLCQVIPNLEMKLKKKTRNIQKKQIINFGKLRDISNYINELVNI 293 Query: 271 R---PVRVDRETLALGYAGVY-SSFLRHCETA----AARYGLSAVDILVEL-GKRRMVGG 321 + AG++ L+ + + + EL GK ++ Sbjct: 294 NSFDHQPYFGKFAFSHKAGLHVDGMLKSSKAYEHINPEIFKSERSFTISELSGKANIIAL 353 Query: 322 QE----------DMIVDVALDLRN 335 + I+D+ +++ Sbjct: 354 SKKFNFQIDKDDKRIIDILEEIKK 377 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 65/354 (18%), Positives = 115/354 (32%), Gaps = 39/354 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 ++I D TLRDG A + +A LD A VD +EV + Sbjct: 7 VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQ--------- 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA----- 120 + I+A A + + D+ + V ++ ++ + A Sbjct: 58 --DEIKAIAGLNPDCLLTA---WCRALKDDIDQSLLCNVTGVHISFPVSDIHLEAMGKTR 112 Query: 121 --------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 I YA + + L + GA + + D+ G Sbjct: 113 SWVLNQLSVLIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLA 172 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 S + + L H H++L + AN+IAA+E G + ++ G+G AG Sbjct: 173 RPSQVENMVHVLSKAAGK-MALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAG 231 Query: 233 NAPLEVFIAAADKLG-WQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 NAPLE + AA L D L + + RP+ + Sbjct: 232 NAPLEQVVVAAGTLDSRSTCVDARRLSEICRYVAEAVNRPIPADQPITGQAVFTHESGIH 291 Query: 288 YSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 + L++ +T G ++ +G+ G ++ + L K Sbjct: 292 CAGILKNPDTYQPFNPETVGRERAQLV--IGRHSGSGMIRHVLAKAGVRLEEGK 343 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 71/372 (19%), Positives = 135/372 (36%), Gaps = 36/372 (9%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M +++YI D TLRDG +S+E+ + I L++ VD +E + + + Sbjct: 104 MARERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFK 163 Query: 61 FGAHSDLEWI------EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 + +++ A V +++LL + + +W R+ T+ Sbjct: 164 RRQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAVCFVAKSWDYHVRLALGCTNEE 223 Query: 115 EADVSAQHIQYARELGMDT---VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + AR G + + PE AK GA + + D+ G Sbjct: 224 NLESITASVTAARMAGREALVDCEHFFDGYKANPEYALACAKAAYSAGARWVVLCDTNGG 283 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ A+K + P G+HAH++ VA S+AA++ G + +L G+G Sbjct: 284 TQPLEVAAIVEAVK-AVVPGESLGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGERC 342 Query: 232 GNAPLEVFIAAADKLGW-----QHGTDLYALMDAAD-------DLVRPLQDRPVRVDRET 279 GNA L I + + G +L L RP ++ Sbjct: 343 GNANLVSLIPTLVLKPYWAERFELGIKPASLKSITRISRAFDDILNRPATEQAPYTGTSA 402 Query: 280 LALGYAGVYSSFLRHCETA----AARYGLSAV----------DILVELGKRRMVGGQEDM 325 A S+ ++ +T G S + + EL +R + ++D+ Sbjct: 403 FATKAGIHASALMKEPQTYEHIPPESVGNSRRVMVSDQGGKSNFIAELERRGIRVAKDDV 462 Query: 326 IVDVALDLRNNK 337 +D + L + Sbjct: 463 RLDTLIALVKER 474 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 62/336 (18%), Positives = 114/336 (33%), Gaps = 40/336 (11%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N KK+ + D TLR+G ++ + QIA LD VD IE++ Sbjct: 23 NPKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEISPVVSNDHK------ 76 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV--- 118 E + A I + G D+ + A+ ++ + Sbjct: 77 ------EATKTIIKQGLKADIVSH---GRALKEDIDVSLDCDAKWCAAYLGISDIHLKDK 127 Query: 119 -----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + ++YA+ G+ + PE L K K +E G I + D Sbjct: 128 LRISREDAMERAVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPD 187 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + + + + ++ + + H H+++ VAN+ +A + G D+I ++ G+ Sbjct: 188 TVGILRPIGMYNFVKKVRDSI--DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGI 245 Query: 228 GAGAGNAPLEVFIAAADKLGWQHG-TDLYALMDAADDLVRPLQDRPV----RVDRETLAL 282 G G PL A L L L+D + + +P V Sbjct: 246 GERTGIPPLAEVAVALTYLYKSPNDFRLDMLLDLSRLIEEYTTIKPYDSKPIVGSSAYKH 305 Query: 283 GYAGVYSSFLRHCETA----AARYGLSAVDILVELG 314 ++ LR+ G + EL Sbjct: 306 KAGTHLAAILRNPAAYEPIPPRAVGNRRRIVFGELA 341 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 204 bits (518), Expect = 4e-51, Method: Composition-based stats. Identities = 56/343 (16%), Positives = 109/343 (31%), Gaps = 20/343 (5%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN---- 58 +K+ D TLRDG A + ++A L+ A +++IE + + Sbjct: 5 KRKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSKEDFISTQKI 64 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 S+ I + + R + + Sbjct: 65 SKILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKKRKMSRQDGIEE 124 Query: 119 SAQHIQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + + YARE G+ + + + + + + GA I + D+ G +DI Sbjct: 125 IKKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQSGANQIILADTTGYAMPNDI 184 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 D + K + + +H H++L L V NS A+ G D I ++ G+G AGN +E Sbjct: 185 YDLVKLSKRCISKSIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGGIGERAGNTSIE 244 Query: 238 VFIAAADKLG----WQHGTDLYALMDAADDLVRPL----QDRPVRVDRETLALGYAGVYS 289 +A G + L + L + + + Sbjct: 245 QVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKYVFSTAAGIHQQ 304 Query: 290 SFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVD 328 L +T +G + ++ K +D++ Sbjct: 305 GILNDPKTYEFVLPEDWG-RTREFYID--KHSGKSILKDVVEK 344 >UniRef50_C8PPD2 Oxaloacetate decarboxylase alpha subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PPD2_9SPIO Length = 624 Score = 204 bits (518), Expect = 5e-51, Method: Composition-based stats. Identities = 65/338 (19%), Positives = 115/338 (34%), Gaps = 29/338 (8%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K+ ISD+ LRD ++ + + ++ I LD S+E G F Sbjct: 4 KVRISDLVLRDAHQSLHATRMTTADMLPICSKLDSVGYWSLEAWGGATFDAC---IRFLN 60 Query: 64 HSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATHC 113 E + + + + I LL +K A G V R+ Sbjct: 61 EDPWERLRSLHKALPNTPIMMLLRGQNLLGYRHYADDVVDAFVKAAADNGVGVFRIFDAL 120 Query: 114 TEADVSAQHIQYARELGMDTVGFLMMS--HMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + A++ G + + T + A+ AK +GA I + D G Sbjct: 121 NDPRNLKRAADAAKKTGKHVQMAISFATTPYHTIDKYAELAKTYTEFGADSICIKDMAGL 180 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + D D A+K + +H H L VA + A E G D +D +++ M G Sbjct: 181 LKPFDAFDLVTAIKKK--TSIPINIHTHATTGLSVATLLKAAEAGADILDTAISSMSMGT 238 Query: 232 GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY------- 284 ++P E + G D+ L++ A R ++ + + L Sbjct: 239 SHSPTETMVEIFRGTEMDTGLDINLLLEIAA-YFREVRKHYAQFESSFLGADTRILVSQV 297 Query: 285 -AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ A + A +L E+ + G Sbjct: 298 PGGMLSNLENQLRDLKASDKMDA--VLKEIPIVQKDCG 333 >UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT Length = 392 Score = 204 bits (518), Expect = 5e-51, Method: Composition-based stats. Identities = 57/349 (16%), Positives = 104/349 (29%), Gaps = 44/349 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 D TLRDG + + + L V IEV + + Sbjct: 14 FVDTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKV------ 67 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS-------- 119 ++ A + D A + G R V ++ ++ ++ Sbjct: 68 --------LLSLPVPAEIFPWLRPVEEDFDAALRLGFRRVHISFPTSDLHMAVLRRVGRE 119 Query: 120 ------AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + + E G L + L K ++ G + D+ G + Sbjct: 120 ETLDRVRRAVCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHH 179 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 ++ +R AL +H H++L L AN++AA G + ++ G+G AGN Sbjct: 180 PLEMSERISAL---ASCGLPIEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGN 236 Query: 234 APLEVFIAAA--DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 A +E A G + G D L + L R L V Sbjct: 237 AAMEEVAFALAFSGEGGETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGSRIFHHSSGIH 296 Query: 288 YSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 ++ GL I+ + G ++++ + Sbjct: 297 VDGVIKEPSNYELFPPELVGLKRKIIVT---HQTGRAGIKNVLERMGYR 342 >UniRef50_D0ANI5 Predicted protein n=1 Tax=Enterococcus faecium C68 RepID=D0ANI5_ENTFC Length = 527 Score = 203 bits (517), Expect = 7e-51, Method: Composition-based stats. Identities = 67/340 (19%), Positives = 135/340 (39%), Gaps = 10/340 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I D TLRDG + ++ +N ++I L ++ ++ IE + +N Sbjct: 1 MN--NVQILDCTLRDGGYCNNWEFGFDNTKKIISGLIESGIEIIECGFLTN--KTVYNKN 56 Query: 61 FGAHSDLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 ++ LE + + K+ ++ G I DL + + +R+A H + + Sbjct: 57 VTKYTTLEELAQIIPEKREGKLFVAMMNYGEYNIEDLPDYDGSSIDGIRIAFHKKNCNEA 116 Query: 120 AQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRD 179 + + ++ G M+S T E K + + Y+VDS G M D+ Sbjct: 117 LKLCREIKKKGYLVFVQAMVSLNYTDEEFLAVIKNVNQFKPYAFYIVDSFGMMKGKDLTR 176 Query: 180 RFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPL 236 F ++ L+ + Q G H+H+N+ L +N+ + +R ID+S+ GMG GAGN Sbjct: 177 LFYMIEHNLEKDIQIGFHSHNNMQLAYSNAQKLITVQTNRSLIIDSSVYGMGRGAGNLNT 236 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR-PVRVDRETLALGYAGVYSSFLRHC 295 E+F+ + + L L+ D+++ + + ++ + Sbjct: 237 ELFVEYLNDNAGK-KYQLKPLLYIIDEILNSFYQKSYWGYSLPNYISAVHNAHPNYASYL 295 Query: 296 ETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + +I + + + V + I D+ Sbjct: 296 SYKNTLTIEAMNEIFEMMDEEKKVSYDKQYIEDLYYKYME 335 >UniRef50_C6J6G8 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J6G8_9BACL Length = 322 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 130/276 (47%), Gaps = 7/276 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSSFN 58 M K I D T+RDG +S+E V+++ L++A VD +E+ + + + + Sbjct: 1 MKANKCKIVDCTIRDGGLVNNWDFSVEFVQKLYAGLNEAGVDYMEIGYKNSPKLLKGADE 60 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 G D +++ K++ L+ G +D+ ++ ++RVA + + D Sbjct: 61 AGPWRFLDDDFLRKVIPQKGTTKLSALVDIGRVDENDILPRSESLLDLIRVACYIKDVDK 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + Q +Q + G +T +M L + ++++ +Y+VDS G+++ D+ Sbjct: 121 ALQLVQLFHDRGYETTLNIMALSNVMEHELLEAFEMIKDSVVDVVYIVDSYGSLDYKDME 180 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 K L P + G+H H+N+ L +N++ A E G + +DAS+ GMG AGN P E+ Sbjct: 181 HLVNKFKTHL-PGKRLGVHTHNNMQLAFSNTLVAAENGVELLDASVYGMGRAAGNCPTEL 239 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVR 274 + L +++ ++L+ PL+++ Sbjct: 240 LVTHLKG----TNYKLRPVLEVLEELLIPLREKEEW 271 >UniRef50_C6CWI0 Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWI0_PAESJ Length = 320 Score = 203 bits (516), Expect = 9e-51, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 135/307 (43%), Gaps = 15/307 (4%) Query: 1 MNGKK--LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSS 56 MN K I D T+RDG +S+E V+ + L++A VD +E+ + + + + Sbjct: 1 MNSKTSHCKIVDCTIRDGGLVNNWDFSVEFVQHLYNTLNEAGVDYMEIGYKNSPKLLKGA 60 Query: 57 FNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA 116 G D +++ + K++ L+ G +D+ ++ ++RVA + + Sbjct: 61 DTAGPWRFLDDNFLKQVIPNKGNTKLSALVDIGRVDENDILPRSESLLDLIRVACYIQDV 120 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 D + Q +Q E G +T +M L + +L++ +Y+VDS G++ +D Sbjct: 121 DKALQLVQLFHERGYETTLNIMALSNVMENQLIEAFELIKESVVDVVYIVDSYGSLKPND 180 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 + L P + G+H H+N+ L AN++ A E+G + +DAS+ GMG AGN Sbjct: 181 YSYLIEKFQHHL-PNKRLGIHTHNNMQLAFANTLLAAEKGVELLDASVYGMGRAAGNCNT 239 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCE 296 E+ +A ++ ++D + + PL+++ + + L Sbjct: 240 ELLVANLQNAK----YNVRPVLDMIEKYMIPLREKEEWGYIIPY------MITGMLDEHP 289 Query: 297 TAAARYG 303 +A Sbjct: 290 RSAMALR 296 >UniRef50_O27179 Pyruvate carboxylase subunit B n=36 Tax=cellular organisms RepID=PYCB_METTH Length = 568 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 117/340 (34%), Gaps = 30/340 (8%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + + + RD ++ + ++ IA+ +D S+E G Sbjct: 2 KGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLN-- 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E + + VK I LL P ++ +++ G V R+ Sbjct: 60 -EDPWERLRELKEHVKRTPIQMLLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDA 118 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + I+ ARE G + S T E+ A+ +E + + D G Sbjct: 119 LNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFARELEALECDSVAIKDMAG 178 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ D + RALK E + +H H + + AA E G D +D +++ + G Sbjct: 179 LISPHDAYELVRALKEE--TDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWG 236 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRET---------LA 281 A P E +AA + G DL ++ ++ + + + Sbjct: 237 ASQPPTESIVAALRDTPYDTGLDLE-ILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIY 295 Query: 282 LGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + + A ++L E+ + R G Sbjct: 296 QIPGGMLSNLVAQLKEQNALDRYE--EVLEEMPRVRKDMG 333 >UniRef50_D1B6M4 Pyruvate carboxylase n=2 Tax=Synergistaceae RepID=D1B6M4_THEAS Length = 507 Score = 202 bits (513), Expect = 2e-50, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 123/341 (36%), Gaps = 30/341 (8%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +++ I++ RD +I + E++ IA+A+D S+EV G++F+ Sbjct: 44 PRRIGITETAFRDAHQSIMATRLRTEDMIPIAEAMDQVGYHSMEV-----WGGATFDACM 98 Query: 62 GAHSDLEWIEAAADV--VKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRV 109 + W + + K+ LL +K A G ++R+ Sbjct: 99 RFLDEDPWERLRELRRRMPNTKLQMLLRGQNLVGYRHYADDVVREFVKRAVGNGIDIIRI 158 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVD 167 + + G + S + T E+ KQA+ M GA I + D Sbjct: 159 FDALNDLRNMEVAADQVKREGAHLQLAISYTISPVHTLESFVKQAEDMVSMGADSICIKD 218 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G ++ ++ A+K+ + +H+H+ +A++ G D +D +++ Sbjct: 219 MAGLLSPTEAGKLVSAIKSRIGR-VPLQVHSHYTSGFAAMTYLASIMAGADVVDCAISPF 277 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDR-------ETL 280 G E +AA + G L L+ A+ R + + + Sbjct: 278 SMGTSQPATETMVAALAGGAFDTGLSLEKLLPVAEHFSRLREKYSKLIMGVQGVDINILI 337 Query: 281 ALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+YS+ + A + L ++L E+ + R G Sbjct: 338 YQVPGGMYSNLQSQLKEQGALHKL--REVLEEVPRVRKEMG 376 >UniRef50_C0QLF7 Pcb n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QLF7_DESAH Length = 683 Score = 201 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 117/349 (33%), Gaps = 36/349 (10%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 L I D++LRDG ++ + E++ +A+ +D ++EV G + F Sbjct: 22 KNPLKIMDLSLRDGHQSLFATRGRTEDMIPVAERMDAVGFWAVEVWGGATFDSM---HRF 78 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 E I K + LL + A + G V R Sbjct: 79 LNEDPWERIRTLKRYFKKTPFSMLLRGQNLVGYRNYADDVAKAFVNRACENGMDVFRTFD 138 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMS--------HMTTPENLAKQAKLMEGYGATCI 163 + + + G G + S + T E +AK + GA I Sbjct: 139 ALNDYRNFEAVVPVIKSCGKHFQGSICYSLTEPRMGGTVYTLEYYVNKAKELVDLGADSI 198 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D G M D D +ALK + + +H+H + + AVE G D +D Sbjct: 199 CIKDMAGLMAPYDAFDLVKALKESV--DIPINLHSHFTSGMAPMTHLKAVEAGVDILDTC 256 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRET---- 279 L + LE + + G D+ L + L + + + + +T Sbjct: 257 LTPYAYRTSHPALEPMVMSLIGTDRDTGFDIETLASINETLEKEILPKYRHLLDDTKVSV 316 Query: 280 ----LALGY--AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 + L G+ S+ + A LS ++ +L + R GQ Sbjct: 317 IDINVLLHQTPGGMLSNLVNQLRDMDALDRLS--EVFEQLPRVRKELGQ 363 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 201 bits (510), Expect = 5e-50, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 107/310 (34%), Gaps = 35/310 (11%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G Y+ E +IA ALD+ VD IE+ H + Sbjct: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDV-----------F 50 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------------ 115 ++ A+ + ++ I D+ + G V + +E Sbjct: 51 RGMKLIAEQGLNVELLAH---SRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLD 107 Query: 116 --ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + ++ I+YA++ G+ + T NL + +L + I V D+ G+ + Sbjct: 108 HALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTH 167 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + + + +H H++L L +AN+I +E G +DA++ G+G AG Sbjct: 168 PLRFYTLVKKI---VNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGI 224 Query: 234 APLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL----QDRPVRVDRETLALGYAGVYS 289 L I L L ++ + Q V S Sbjct: 225 VDLAQIITVLYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVS 284 Query: 290 SFLRHCETAA 299 + L+ Sbjct: 285 AVLKDPRFYE 294 >UniRef50_B2A6U5 Conserved carboxylase region n=10 Tax=Bacteria RepID=B2A6U5_NATTJ Length = 633 Score = 201 bits (510), Expect = 5e-50, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 118/337 (35%), Gaps = 29/337 (8%) Query: 6 LYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I+D +LRD ++ + ++ I + +D+ S+E+ G Sbjct: 3 VKITDTSLRDAHQSLFATRMRTGDMVPILETIDNVGFHSLEMWGGATFDSCMRFLD---E 59 Query: 65 SDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATHCT 114 E + VK+ K+ LL P +K G ++R+ Sbjct: 60 DPWERLRVIRKYVKNTKLQMLLRGQNIVGYKNYPDDVLEEFIKKTVANGMDIIRIFDAVN 119 Query: 115 EADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + I++ + G G + S + + AK ++ G I V D G + Sbjct: 120 DLRNMEKAIEFTKREGAHAQGTICYTISPVHNNNVFVQFAKDLKETGCDSICVKDMAGLL 179 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + D + LK E+ +H+H + I ++E G D +D +++ G Sbjct: 180 SPYKGYDLVKRLKEEVG--LPVQIHSHSTSGMATTTYIKSIEAGADIVDTTISPFALGTS 237 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY-------- 284 P+E A + + D AL + ++ + ++ + + + + Sbjct: 238 QPPVEPVEAMLSETEKELELDGDALTEMSE-YFKGMKKKYEKYSKLAFTVDTNVLNYQVP 296 Query: 285 AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ A A + L E+ K R G Sbjct: 297 GGMISNLTSQLSDANAIEKYD--EALQEIPKVREELG 331 >UniRef50_C9LXD4 Putative uncharacterized protein n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LXD4_9FIRM Length = 538 Score = 200 bits (509), Expect = 5e-50, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 141/334 (42%), Gaps = 9/334 (2%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLRDG + ++ + + +I + L + V+ IEV D + SSF+ G D Sbjct: 6 LLDCTLRDGGYVNNWEFGYDRIVEIFERLVSSGVEFIEVGFLD--EKSSFDRGRTVLPDT 63 Query: 68 EWIEAAADVVKH--AKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 + + V A + ++ G +I L+ + +RV ++ + + + Sbjct: 64 ASVSRMFEGVSKGDALVLGMIDYGTCSIERLEPCEETFLDGIRVIFKESKMEAALKFYAE 123 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 ++LG ++ T E LA+ AKL+ +VD+ G ++ + + L Sbjct: 124 VKKLGYKVFAQMVSVTTYTDEKLAEYAKLVNEVMPYATSMVDTYGLLDEEHLCHIYGILD 183 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIAA 242 A L P+ + G HAH+N LG AN+ + +R D +L GMG AGNAPLE + Sbjct: 184 ANLDPQIRVGYHAHNNFQLGYANAKHFLSLDSERGLLADGTLYGMGKSAGNAPLE-LLMM 242 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGV-YSSFLRHCETAAAR 301 D+ +++A D+++ + + + + + +++++ Sbjct: 243 FRNKKQGARYDVNQVLEAIDNVILDIYQKQYWGYNLFFYIASSMHCHPNYVKNLMNKRTL 302 Query: 302 YGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 DIL L + + E I + + ++ Sbjct: 303 SVKQIRDILSSLEVSKSLLYDEAYIEKLYREYQS 336 >UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutaryl-coa lyase n=1 Tax=Nasonia vitripennis RepID=UPI00015B4E2A Length = 327 Score = 200 bits (509), Expect = 6e-50, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 97/302 (32%), Gaps = 37/302 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I +V RDG+ IR E ++ L + S+EV + + Sbjct: 27 VRIVEVGPRDGLQNIRKVLPTETKIELINRLSQTGLRSVEVTSFVSPK------WVPQMA 80 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 D + + + + + L + + L A + G + V + T +E Sbjct: 81 DSAEVYQGVEKNPNVEYSVL----VPNLKGLDKALKLGVKEVVLFTAASETFNQKNINCS 136 Query: 116 ----ADVSAQHIQYARELGMD------TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + + +E + + P N+A A+ + G + + Sbjct: 137 IAESLKNCKEITKICKEKKIKARAVISCIAGCPYEGEIKPVNVANVAEALLDMGCYEVGL 196 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPET-QTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 D+ G + F LK + + +H H +AN + +G D+S+ Sbjct: 197 GDTIGVATPKKMAHLFEELKKMTGGDVWRFAVHCHDTYGQAIANIYECLRQGIRVFDSSV 256 Query: 225 AGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRE 278 AG+G GN E + G++ G DL L+ + + Sbjct: 257 AGLGGCPYAPGASGNVSTEDLVYLLHGEGFETGVDLDKLIQVGQFISEQIPSTNHSKAGS 316 Query: 279 TL 280 + Sbjct: 317 AV 318 >UniRef50_C0FUY3 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FUY3_9FIRM Length = 431 Score = 200 bits (508), Expect = 8e-50, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 140/334 (41%), Gaps = 11/334 (3%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + + D TLRDG + ++ +N+ I + L DA VD IE+ D F+ Sbjct: 3 NIRLLDCTLRDGGYVNDWKFGHDNLVGIFERLVDANVDIIEIGFLD--DRRPFDIDRSIM 60 Query: 65 SDLEWIEAAADVV--KHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 + E V K+ + ++ G I +++ + +RV + ++ Sbjct: 61 PNTACAEKIWKDVEHKNVMVVGMIDYGTCDISNIQPCCDSFLDGIRVIFKEHLMKEAMEY 120 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + ++LG L+ T E++ + +L+ + +VD+ G + + + + + Sbjct: 121 CRQIKKLGYKVFAQLVSVTTYTKESMLELIELVNDVKPYAVSMVDTYGLLKPNTLLEYYE 180 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD----RIDASLAGMGAGAGNAPLEV 238 L + PE Q G HAH+N L AN++A V + +D +L GMG AGNAP+E+ Sbjct: 181 ILDEYVYPEVQIGFHAHNNFQLAYANALAFVSKPNKKHDIVVDGTLFGMGKSAGNAPIEL 240 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLAL-GYAGVYSSFLRHCET 297 + ++ + + A++++ ++ + ++ + L + S+L + E Sbjct: 241 LAMSLNE-DFNKNYQINAMLESVEESIMDFFEQSPWGYKMFFYLCALNKCHPSYLSYYEK 299 Query: 298 AAARYGLSAVDILVELGKR-RMVGGQEDMIVDVA 330 DIL E+ + + + ++ Sbjct: 300 KENLSISKLNDILSEIEPVPKKLLYDKKSADELY 333 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 199 bits (507), Expect = 8e-50, Method: Composition-based stats. Identities = 59/336 (17%), Positives = 109/336 (32%), Gaps = 42/336 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I+D TLRDG A ++ E +IAK L +A D +E+ + + Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAERED------- 54 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 ++ L+ T DL+ + G + V ++ + Sbjct: 55 -------IRAILSLGLPLRLMSWNRATQSDLEASLACGMKAVDLSIPVSTKMVAAKFRGK 107 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + + A++ G+ + + L + L GA + D+ G Sbjct: 108 YAKVLSNLEETLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGI 167 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + R+L+ MH H++ + VANSIA +E G ++ ++ G+G A Sbjct: 168 LTPLQTYRAIRSLRRHCT--LPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERA 225 Query: 232 GNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 GNA E + + + G D L + + L V Sbjct: 226 GNAGFEQVLLSLIGQFGQNRTLDSTILKALVQKVAKAAGVALAPTAPVVGSRLFWHESGI 285 Query: 287 VYSSFLR----HCETAAARYGLSAVDILVELGKRRM 318 + + + G S +GK Sbjct: 286 HADGNQKSEGLYEPFSPELVGASREY---PIGKHSG 318 >UniRef50_A8ZRW8 Conserved carboxylase region n=6 Tax=Bacteria RepID=A8ZRW8_DESOH Length = 681 Score = 199 bits (507), Expect = 9e-50, Method: Composition-based stats. Identities = 68/348 (19%), Positives = 124/348 (35%), Gaps = 36/348 (10%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 L I D++LRDG ++ + E++ +A +D+ ++EV G + F Sbjct: 23 NPLKIMDLSLRDGHQSLFATRGRTEDMLPVAGLMDEVGFWAVEVWGGATFDTM---HRFL 79 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E I K ++ LL ++ A + G V R Sbjct: 80 NEDPWERIRTLKRYFKKTPLSMLLRGQNLVGYRNYADDVARAFVERAAENGMDVFRTFDA 139 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGATCIY 164 + ++ ++ G G + S + E +AK +E GA I Sbjct: 140 LNDFRNFETVVEVIKKCGKHFQGTICYSMTEPRLGGEVYNVEYFVTKAKELESMGADTIC 199 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D G + DI + +ALK +KP H+H L + + AVE G D +D L Sbjct: 200 IKDMAGLVAPYDIFNVVKALKESVKP--PIHFHSHFTSGLAPMSHLKAVEAGVDILDTCL 257 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP--------VRVD 276 + + +E + + G D+ L++ + L + + + V Sbjct: 258 SPYAYRTSHPAVEPMVMSLLGTNRDTGFDINKLVEITEILEEKVMPKYRQFLNEPTMSVI 317 Query: 277 RETLALGY--AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 + L G+ S+ + A L+ ++ EL + R GQ Sbjct: 318 DINVLLHQTPGGMLSNLFGQLKEMDALDRLN--EVYKELPRVRKDLGQ 363 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 80/357 (22%), Positives = 132/357 (36%), Gaps = 45/357 (12%) Query: 1 MNG-KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M + L + D TLRDG +SL + IA+ALD A V IEV Sbjct: 1 MTPDRTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVG-----------I 49 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---- 115 +++ I A + HA +HDL A + G + V A + Sbjct: 50 AAMGWAEVAEIRAVVAEIAHATPVV---WCRLRMHDLDMAQKTGVKRVHFAVPTSTAQLE 106 Query: 116 ----------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 +A + A + G+ + T P+ L + A++ GA + Sbjct: 107 GKLRVDRDWILRETAALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRI 166 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G ++ L A + MHAH++ + AN+I A G + ++ Sbjct: 167 ADTLGLLDPLGAFRLVAELSARIS--LPIEMHAHNDFGMATANTIMAAHAGATHLSVTVN 224 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD-----RPVRVDRETL 280 G+G AGNA E AA + G G DL AL + + + + +P+ D Sbjct: 225 GLGERAGNAACEEVGAALEAGGIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLF 284 Query: 281 ALGYAGVYSSFLRHCETA------AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 A + L+ +T AR+G + + +GK G +++ L Sbjct: 285 AHESGIHVDAILKRADTYEDPRCAPARFG---RERQIVIGKHSGSAGLRAALLEAGL 338 >UniRef50_C3PVE7 Pyruvate carboxyltransferase n=2 Tax=Bacteroides RepID=C3PVE7_9BACE Length = 528 Score = 199 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 124/334 (37%), Gaps = 9/334 (2%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLRDG + + + I K L+ A D IEV D F+ Sbjct: 1 MLDCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEVGFLD--DRREFDINRSIMPST 58 Query: 68 EWIEAAADVVKHAK--IATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 E I VK K ++ G ++ + + +RV + D + + Sbjct: 59 EAINKIFGSVKKGKAIPVAMIDFGTCSLDSIGSCDSTFIDGIRVIFKKEKIDQALPFCKA 118 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 +E G + + + + + +VD+ G ++ S + F + Sbjct: 119 IKEKGYKLFIQAISITAYSDIEMLEYVNRINEIKPYAFSIVDTYGLLDNSSMARYFYLID 178 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVFIAA 242 L P + G H H+N LG +N+I +E+ R D+++ GMG AGN E+ Sbjct: 179 NNLDPSIKMGYHEHNNFQLGFSNTIKFLEKSTKRTLVADSTVYGMGKSAGNCASELLAMH 238 Query: 243 ADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRVDRETLALGYAGVYSSFLRHCETAAAR 301 ++ H DL L++ D + P+ Q + + S++++ + Sbjct: 239 LNEYYGGH-YDLNQLLEIVDTDLMPIYQKHYWGYKYDFYIASMQRCHPSYVQYLLKKSTL 297 Query: 302 YGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 S +IL + + + + I LD +N Sbjct: 298 SVSSINEILSSIPEEIKLLYNKQWIEQAYLDYQN 331 >UniRef50_P13187 Oxaloacetate decarboxylase alpha chain n=404 Tax=cellular organisms RepID=DCOA_KLEPN Length = 596 Score = 199 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 59/341 (17%), Positives = 119/341 (34%), Gaps = 33/341 (9%) Query: 5 KLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + I+DV LRD ++ + L+++ +A LDD S+E G++F+ Sbjct: 2 TVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLEC-----WGGATFDACIRF 56 Query: 64 HSDLEWIE--AAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 + W+ + + LL ++ A + G V RV Sbjct: 57 LGEDPWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFD 116 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + +Q R G G L S T + + + G + + D Sbjct: 117 AMNDPRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTEQLLETGVDSVAIKDMS 176 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G + + +K + +H H + + A+E G D +D +++ M A Sbjct: 177 GILTPHAAFELVSEIKKRY--DVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSA 234 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRV--------DRETLA 281 G+ E +A + G D++ L ++ R ++ + R +A Sbjct: 235 TYGHPATEALVATLAGTPYDTGLDIHKL-ESIAAYFREVRKKYHAFEGQLKGTDSRILVA 293 Query: 282 LGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 G+ ++ + +A + L ++L E+ + R G Sbjct: 294 QVPGGMLTNLEGQLKQQSAAHRLD--EVLAEIPRVREDLGF 332 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 199 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 67/346 (19%), Positives = 110/346 (31%), Gaps = 39/346 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + D TLRDG A ++ IA ALD V IE + Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMG-----------VT 70 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ- 124 + + + A+I D++ A G + ++ + ++ + Sbjct: 71 ERDVLREILATDPKAEIVG---WCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLERD 127 Query: 125 --YAR-----------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 +AR + GM + + A + G T + D+ G Sbjct: 128 RAWARRRVRDCVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGL 187 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ DR L + +HAH + L AN+IAAV+ G + ++ G+G A Sbjct: 188 LDPVSAYDRLGRLVRAVPG--PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERA 245 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV-RPLQ-DRPVRVDRETLALGYAGVY 288 GNAP+E A L D + A +V PL + V A Sbjct: 246 GNAPIEEVAMALRHLLKLPIDLDTTSFRTLAQLVVGWPLPAGKKAVVGESVFAHESGIHV 305 Query: 289 SSFLRHCETAA---ARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 LRH T G + +GK + + Sbjct: 306 HGILRHPATYEPFDPEVGGRRR---LTVGKHSGRASLRHALEQCGI 348 >UniRef50_B5W6H6 Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B5W6H6_SPIMA Length = 548 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 122/333 (36%), Gaps = 16/333 (4%) Query: 1 MNGKK--LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 MN D TLRDG + + V A++ A VD +E+ Sbjct: 7 MNQPTLDFCFLDCTLRDGGYYNAWDFPRHIVIDYLNAMEAAGVDIVELGFRSLKNQGFKG 66 Query: 59 YGFGAHSDLEWIEAAADV------VKHAKIATLLLPGIGTIHDL-KNAWQAGARVVRVAT 111 D + V A++ + H + A + R+VR A Sbjct: 67 ACAYTTDDFLRSLPLPERLTIGVMVNGAELLGDMPLEQTLEHLFPETAATSPVRLVRFAC 126 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 H E + +E G LM P+ + ++ Y +Y DS G+ Sbjct: 127 HIHEFQQVLPASTWLKERGFQVGFNLMQVADRLPQEIETLSQQACNYPLDVLYFADSMGS 186 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 MN + L+ + G+H H N+ + + N++ A+E G +DA++ GMG G Sbjct: 187 MNPQHTLEIINRLRTHW--QGALGIHTHDNMGMALQNTLQALEAGVTWLDATVTGMGRGP 244 Query: 232 GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP-VRVDRETLALGYAGVYSS 290 GNA E + Q L LM + RPLQ+ + G G++ S Sbjct: 245 GNAKTEYLALELGQR-RQKPCSLVRLMSLIEGFFRPLQNTHGWGTNTYYYLAGKHGIHPS 303 Query: 291 FLRHCETAAARYGLSAVDILVELGKRRMVGGQE 323 +++ + S DIL + R+ GG++ Sbjct: 304 YIQSMLGDS---RYSPEDILAVIEHLRVEGGKK 333 >UniRef50_C4XTF5 Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XTF5_DESMR Length = 345 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 85/339 (25%), Positives = 149/339 (43%), Gaps = 9/339 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + + + TLRDG + + E A+ L IEV HG GL Sbjct: 2 KNVTLLECTLRDGAYKVDFMIDQETCCAFAEKLVRIGFQDIEVGHGLGLGAYRQYS--AG 59 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 +D + A + +++ + +P +G D + A G +RV S + Sbjct: 60 FTDEALYKRLAPLAARSRLYSFFIPSVGKPDDFRMARDYGLYGLRVGAEPVYVLDSIPTL 119 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ LG +M S+ TP+ AK + ++ + IY+VDS G M ++R RA Sbjct: 120 EAAKSLGYFVALNVMKSYTVTPDGFAKLVETVKDF-VDVIYLVDSAGHMLPEELRAYVRA 178 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 ++ + G H H+NL L VA+++ ++EG ID +L G+G GN P E +A Sbjct: 179 IQDRVG-MIALGYHGHNNLGLAVASALELLDEGVQYIDTTLTGIGRSGGNIPTETMLAVL 237 Query: 244 -DKLGWQHGTD--LYALMDAADDLVRPL--QDRPVRVDRETLALGYAGVYSSFLRHCETA 298 K G Q+ +D L + A + + + + E + GYAG +SS+ Sbjct: 238 AKKYGVQYCSDDFLLQTLGVARQFREYVLSKGKSLDFRSEDILFGYAGFHSSYEDLLRRE 297 Query: 299 AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 A R G ++++ +R V E ++ D+ ++ ++ Sbjct: 298 AERQGQDFHQAILDVSRREQVCLTEAILTDIFREISASQ 336 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 104/306 (33%), Gaps = 39/306 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +K+ I D TLRDG +S E+ +IA+ L + V+ IE + Sbjct: 28 PQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSK--------- 78 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVR-------------- 108 D + IE A KI D+ A GA + Sbjct: 79 --DDAQAIEEIAKRNLGPKIMVFCRAMR---EDVDRAVDCGADGIVLEAPSGYPKLKYQF 133 Query: 109 --VATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLM-EGYGATCIYV 165 T + + I YA+E G+ F + L + + + V Sbjct: 134 ASKWTEESLTEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVTTQAKPDSVTV 193 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 VD+ G++ + +R R ++ + +H H++ LG A + AAVEEG + + + Sbjct: 194 VDTTGSITPTAMRFLVRQVRETIA--LPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCIN 251 Query: 226 GMGAGAGNAPLEVFIAAAD-KLGWQ-HGTDLYALMDAADDLVRP----LQDRPVRVDRET 279 G+G GN LE G + + L + + ++ R L V Sbjct: 252 GLGERTGNTALEEIALGLKLLYGIELPKFNFQKLSELSQEVQRMSGKTLAQNKPVVGLLP 311 Query: 280 LALGYA 285 Sbjct: 312 FTREIG 317 >UniRef50_C1DTS7 Pyruvate carboxylase subunit B (Pyruvic carboxylase B) n=9 Tax=Bacteria RepID=C1DTS7_SULAA Length = 647 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 60/344 (17%), Positives = 122/344 (35%), Gaps = 31/344 (9%) Query: 3 GKKLYISDVTLRDGMHA-IRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 K + I+D+T RDG + + +++ + + +D A ++EV G + Sbjct: 20 PKPIKITDLTPRDGQQCKLATRVRTDDLLPLCEKMDKAGFYAVEVWGGATFD---VCLRY 76 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 E ++ +V+ K+ L ++ A + G V RV Sbjct: 77 LKEDPWERLKRIKEVMPRTKLQMLFRGQNIVGYKPKSDKVVKKFVEKAIEHGITVFRVFD 136 Query: 112 HCTEADVSAQHIQYARELGMDT--VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + ++ +E G + S + T E A + I D+ Sbjct: 137 SLNDNRNIEVAVKAIKEFGGEVHAEISYTKSPVHTLEKWMSYADELIDLEPDWICFKDAT 196 Query: 170 GAMNMSDIRDRFRALKAELK----PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 G + D + R +K ++K + +H H + N + A+ G D +D L+ Sbjct: 197 GILMPEDTYNIIRGIKQKIKEKANDRIKLVLHNHDMSGTAIMNHMMAILAGVDMVDTVLS 256 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY- 284 + G+ + E +AA + G DL L + A+ + R ++ + + + E + Sbjct: 257 PLAFGSSHPATESVVAALKDTPYDTGLDLKVLDELAE-ITREIKKKYKKYETEYAGVNAK 315 Query: 285 -------AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + A A + + L E+ G Sbjct: 316 VLIHKIPGGMISNMVAQLMEANALDKME--EALEEVPNVERDLG 357 >UniRef50_Q5ZS38 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legionella pneumophila RepID=Q5ZS38_LEGPH Length = 295 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 127/285 (44%), Gaps = 5/285 (1%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN + I D +LRDG H + +++++I LD++ ++ IE+ + +G N G Sbjct: 1 MNP--VSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIG 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 +++ ++K AKIA ++ P DL G +++R+ + + Sbjct: 59 KAGMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAV 118 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I+ A+ L +T ++ T L + + + IY DS G++ I Sbjct: 119 PLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDMIYFADSNGSLFPDRINCL 178 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 ++ + K G HAH NL L AN++AAV G IDASLAGMG G GN E FI Sbjct: 179 YKKYTRQYK--VSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFI 236 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYA 285 A + +L ++ AA+ + L+ ++ G + Sbjct: 237 AYLHANNIK-KYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGIS 280 >UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM Length = 315 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 110/294 (37%), Gaps = 37/294 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK+ I +V LRDG+ + ++ E ++ + A IEV + Sbjct: 1 MLPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEVGSFMSPKA------ 54 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 ++ + + + V + L+ + ++ A G + V++ + A A Sbjct: 55 VPQMANTDEVYEKLEKVPGVEYRALI----ANLRGVERAIACGCKKVKLNVSASRAHNLA 110 Query: 121 QH--------------IQYARELGMDTVGFLMMSHMTTPEN------LAKQAKLMEGYGA 160 + A+E G++ G + M+ + + +A + G Sbjct: 111 NLNRTPEESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKEIPIGAVASIVEAYMAVGI 170 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ G +++ +K +H H+ LG+AN +A ++ G + Sbjct: 171 NEISLSDASGMAFPPQVQEICAYMKKHYPKNMWW-LHFHNTRGLGMANILAGMQSGFTQF 229 Query: 221 DASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 D+S AG+G AGN E + ++ G G D ++ + + + + Sbjct: 230 DSSFAGVGGCPFVPGAAGNVATEDVLNLCEESGIDTGIDFDKALEVSRRVAQLV 283 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 197 bits (501), Expect = 5e-49, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 124/345 (35%), Gaps = 24/345 (6%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG A +S+++ + +ALD +D IE + + Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVKS 62 Query: 65 SDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 +L+ + A + + +LL G + +W + T Sbjct: 63 VELKHSKLVAFGSTRRKDVAPEEDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLENN 122 Query: 116 ADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 ++ + + + G + + PE + K + GA + + D+ G Sbjct: 123 LEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYALEALKAAKDGGAEILTLCDTNGGC 182 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 +I + +K +L + + G+HAH+++ GVANSIAAVE G ++ + G G G Sbjct: 183 FPEEISRITKEVKEKLG-DIKIGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGERCG 241 Query: 233 NAPLEVFIAAADKLGWQHGTDLYA--LMDAADDLVRPLQDRPVRVDRETL----ALGYAG 286 NA L IA L+ + ++ + + + + G Sbjct: 242 NANLSTIIANLQLKKDYELVPREKLGLLTSTARIIAEISNITIEDSMPYIGKNAFAHKGG 301 Query: 287 VY-SSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMI 326 ++ + + G +L E+ R + + + Sbjct: 302 MHIDGVSKASHSFEHINPELVGNEREFLLSEVSGRSTILEEIRRV 346 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 197 bits (501), Expect = 5e-49, Method: Composition-based stats. Identities = 77/356 (21%), Positives = 128/356 (35%), Gaps = 42/356 (11%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I+D TLRDG ++ QIA AL D VD IEV + Sbjct: 33 RVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGTPAMGR----------- 81 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ--- 121 + E I A ++ D+ +A +G +V ++ + ++A+ Sbjct: 82 DEQEAIRRIAKAGLPLRVIA---WCRMRRGDVDDAIASGVSIVNLSAPVSRFQIAAKFGG 138 Query: 122 -----------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 I YAR G++ S T + L + GA D+ G Sbjct: 139 SLPRVVAAVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLG 198 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 ++ IR A++ + H H +L L AN++AA+E G ++ G+G Sbjct: 199 VLDPISIRAAIEAVRR--ITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGER 256 Query: 231 AGNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYA 285 AGNAPLE A D L L AL ++ + R + V ++ Sbjct: 257 AGNAPLEQIAVALDSLFAQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESG 316 Query: 286 GVYSSFLRHCETAAARYGLSAVDILV----ELGKRRMVGGQEDMIVDVALDLRNNK 337 L+ + A LS + +GK + G + + L L ++ Sbjct: 317 IHVDGILKSKDCYEA---LSPRRLGRNHRFVVGKHSGLAGLRHELSYLGLQLTEDE 369 >UniRef50_C0X8H4 Pyruvate carboxylase n=24 Tax=Bacilli RepID=C0X8H4_ENTFA Length = 1152 Score = 197 bits (500), Expect = 6e-49, Method: Composition-based stats. Identities = 55/368 (14%), Positives = 116/368 (31%), Gaps = 38/368 (10%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 N + + ++D T RD ++ + ++ + IA D A E+ + G++F+ Sbjct: 534 NQESVLMTDTTFRDAHQSLLATRVRTQDFKAIAGLTDAA---LPELFSSEMWGGATFDVA 590 Query: 61 FGAHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVR 108 + ++ W + ++ + + L P +K + + G V R Sbjct: 591 YRFLTEDPWQRLRKIRQLMPNTLLQMLFRGSNAVGYQNYPDNVIEEFIKESARQGVDVFR 650 Query: 109 VATHCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGA 160 + + IQ R+ G + + + AK +E GA Sbjct: 651 IFDSLNWIPQMEKSIQVVRDTGKIAEAAICYTGDINDPARAKYNVQYYLDMAKELENLGA 710 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D G + LKA + +H H G+ AA + G D + Sbjct: 711 QIIAIKDMAGLLKPQAAYRLISELKAA--TDLPIHLHTHDTSGNGIITYSAATKAGVDIV 768 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLY---ALMDAADDLVRPLQDRPVRVDR 277 D +++ M + A ++ + +D+ Q ++ Sbjct: 769 DVAMSAMSGATSQPSMNSLYYALVNGERTPTINIDNAQKINHYWEDVRMYYQPFENGLNA 828 Query: 278 ETLALGYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMIVD 328 + + + + A GL + + G V ++ D Sbjct: 829 PQTEVYMHEMPGGQYSNLQQQAKAVGLGHRWDEIKKMYHTVNLMFGDIVKVTPSSKVVGD 888 Query: 329 VALDLRNN 336 +AL + N Sbjct: 889 MALFMVQN 896 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 67/359 (18%), Positives = 132/359 (36%), Gaps = 39/359 (10%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 N K + D TLR+G + E +IA+ALDD VD IE+ + S + Sbjct: 33 NVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD--- 89 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------ 115 EA + AKI T + + D + A + G V V ++ Sbjct: 90 --------CEAICKLGLKAKILTHI---RCHMDDARVAVETGVDGVDVVIGTSKFLRQYS 138 Query: 116 --------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 A + + I++ + G++ S + +L K ++ G + + D Sbjct: 139 HGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIAD 198 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G N + + R LK+ + + H H++ +AN+ A+E G ID S+ G+ Sbjct: 199 TVGCANPRQVYELIRTLKSVVSCD--IECHFHNDTGCAIANAYTALEGGARLIDVSVLGI 256 Query: 228 GAGAGNAPLEVFIAAADKL---GWQHGTDLYALMDAADDLVRPLQ---DRPVRVDRETLA 281 G G PL +A + L+ + D + + ++ + Sbjct: 257 GERNGITPLGGLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAF 316 Query: 282 LGYAGVYS-SFLRHCETAA--ARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 AG+++ + L + T + + + + + + L+L +++ Sbjct: 317 THKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQ 375 >UniRef50_C6N5U6 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legionella RepID=C6N5U6_9GAMM Length = 302 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 78/306 (25%), Positives = 130/306 (42%), Gaps = 7/306 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN KK+ + D +LRDG H + + +I ALD + ++ IE+ + +G N G Sbjct: 1 MN-KKIQLLDASLRDGGHRTNFHFQDGALEEILPALDRSGIEYIEIGYRNGSLHPINNLG 59 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 D E++ ++ +AK+A + P DL G ++R+ + Sbjct: 60 RAGWCDKEYLLFCRALILNAKMAVMAHPENVNQDDLLELKNCGVDLLRICIAKDHFSSAI 119 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I+ A+++G++ + T L IY DS G++ S I + Sbjct: 120 PVIKIAKQIGLEVSINFIHISYYTNAELDAVIAEASLQQPDIIYFADSNGSLLPSRINEI 179 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFI 240 + + G HAH N+ L AN++AA+ G IDASLAGMG G GN E FI Sbjct: 180 YDRYINQYA--IPFGFHAHDNIGLAQANALAAMNAGVHFIDASLAGMGKGTGNLKTEFFI 237 Query: 241 AAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAA 300 A + + DL+ ++ AA+ + L+ ++ + GV +T A Sbjct: 238 AYLHAINIK-KYDLHDILYAANYVRDVLKIGHEALEMDEFIR---GVTDLSTADLKTYKA 293 Query: 301 RYGLSA 306 +Y Sbjct: 294 KYMSPP 299 >UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3 Length = 547 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 66/358 (18%), Positives = 110/358 (30%), Gaps = 31/358 (8%) Query: 1 MNGKK--LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 M KK L++ D TLRDG SL + IA+ LD + IE Sbjct: 1 MATKKTSLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQF 60 Query: 59 YGFGAHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV 109 + LE E A V + +L G + +W Sbjct: 61 FWQLQEEPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQ 120 Query: 110 ATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + + I Y R G + + P+ + GA + + Sbjct: 121 TSLAENLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMC 180 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQ------TGMHAHHNLSLGVANSIAAVEEGCDRI 220 D+ G I + ++ L + Q G+HAH++ VANS+ AVE G + Sbjct: 181 DTNGGTLPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMV 240 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMD------AADDLVRPLQDRPVR 274 ++ G G GNA L I + L ++V D Sbjct: 241 QGTINGYGERCGNANLCTLIPNLQLKLDYDCIEPEKLAHLTSTSRLISEIVNLAPDDHAP 300 Query: 275 VDRETLALGYAGVYSSFLRHCET-----AAARYGLSAVDILVELGKRRMVGGQEDMIV 327 + G++ S ++ A G ++ E V + ++ Sbjct: 301 FVGRSAFAHKGGIHVSAVQRNPFTYEHIAPNLVGNERRIVVSEQAGLSNVLSKAELFG 358 >UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO Length = 373 Score = 195 bits (495), Expect = 3e-48, Method: Composition-based stats. Identities = 68/353 (19%), Positives = 115/353 (32%), Gaps = 41/353 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 L + D TLRDG +S E I AL +A V SIE+ Sbjct: 2 RNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIGIPAMGG--------- 52 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV---- 118 E ++ VV A L++ G D++ + G V V + + Sbjct: 53 -----EELDFIKSVVDRQDEARLVVWHRGVREDVERSLDLGFTSVHVGLPTSAGHLKASV 107 Query: 119 ----------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ++ A++ G T L + A ++ GA + + D+ Sbjct: 108 RKDRTWLLATARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + +R A+ + + HAH++ L AN++A ++ G ++ +G Sbjct: 168 VGLLGPEAYGERVAAVLSAA--DIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIG 225 Query: 229 AGAGNAPLEVFIAAADKLG-WQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALG 283 AG A L + A KL G DL L + + + A Sbjct: 226 ERAGMADLAQVVVALKKLYDRDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHE 285 Query: 284 YAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + R + + G+RR V G+ VA L Sbjct: 286 SGIHANGMFRDTSSFEP---FPPEHVG---GERRYVLGKHSGRALVAWALEQE 332 >UniRef50_B7GA98 Precursor of carboxylase pyruvate carboxylase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GA98_PHATR Length = 1264 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 63/364 (17%), Positives = 110/364 (30%), Gaps = 37/364 (10%) Query: 6 LYISDVTLRDGMHAI-RHQYSLENVRQIAKA--LDDARVDSIEVAHGDGLQGSSFNYGFG 62 L I+D T RD ++ + + + + A + A S+E+ G + F Sbjct: 650 LLITDTTWRDAHQSLLATRMRTQELIKSADYTNMALANAFSLEMWGGATFDVAM---RFL 706 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E +EA + V + LL K A +G V RV Sbjct: 707 RECPWERLEALREKVPNVPFQMLLRGANAVGYTNYADNVVHKFCKQAHDSGVDVFRVFDS 766 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGATCIY 164 + + A E G G + + + E A + G + Sbjct: 767 LNYIENLQLGVDAAGEAGGFVEGAMSYTGDVADPTKGKYSLEYYMNLASELVDMGVHSLA 826 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D G + AL+ P+ +H H GVA+ +AA + G D +D+S+ Sbjct: 827 IKDMAGLLTPKASTLLVSALREA-HPDIPIHVHTHDTAGSGVASMLAAAQAGADIVDSSM 885 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDA------ADDLVRPLQDRPVRVDRE 278 L +A G L L L P + + + Sbjct: 886 DAFSGMTSQPSLGALVANLAGTERDTGIQLSNLPPLNSYWEDVRSLYAPFESGQLSGSSD 945 Query: 279 TLALGY-AGVYSSFLRHCETAAARYGLS-----AVDILVELGKRRMVGGQEDMIVDVALD 332 G Y++ L + + + + LG V ++ D+A Sbjct: 946 VYFHEIPGGQYTNLLFQSKQLGLSDRWTEIKTKYAEANIILGDIPKVTPSSKVVGDLAQF 1005 Query: 333 LRNN 336 L + Sbjct: 1006 LVSQ 1009 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 118/315 (37%), Gaps = 34/315 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 I D TLR+G ++ + IAK LD VD IE+ + F +H Sbjct: 38 FEIIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNP-----------FASHQ 86 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 E A A++ AKI + D++ + G V + +E Sbjct: 87 AREDCRAIANLGLKAKIVAHT---RCHMDDVRACVETGIDGVSMYMATSEALRRHSHGKS 143 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 D + + I++ ++ GM+ + + L ++ G + + D+ G Sbjct: 144 VQAVIDSAREVIEFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGI 203 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + A+++ +KPET H H++ +AN++ A++ G I+ + G+G Sbjct: 204 ATPFQVAETVAAVRSIIKPETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERN 263 Query: 232 GNAPLEVFIA---AADKLGWQHGTDLYALMDAADDLVRPLQ---DRPVRVDRETLALGYA 285 G PL F+A D+ ++ DL L + + + + A Sbjct: 264 GITPLGGFLARMYTLDRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNYITGSSAFTHKA 323 Query: 286 GVYSSFLRHCETAAA 300 GV+S + A Sbjct: 324 GVHSKAVMSDPGAYE 338 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 112/349 (32%), Gaps = 38/349 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG A + ++A+ L+ A VD +E S Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFAASSS-----------S 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHCTEADVSAQ--- 121 D E I + V+ + +L + A + A + V + + + Sbjct: 58 DFEAIRRISCCVRGCVVCSLARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEKLRM 117 Query: 122 -----------HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 ++ AR D S P L AK GAT + V D+ G Sbjct: 118 HPLDVVDRAAAMVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTDTVG 177 Query: 171 AMNMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 + D L + +H H+++ L +AN++AA+ + + ++ G+G Sbjct: 178 HGIPEQLSDVAGMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVTGIG 237 Query: 229 AGAGNAPLEVFIAA----ADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETL 280 AGNA LE + A G D + A R L V Sbjct: 238 ERAGNAALEEVVVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGCHAF 297 Query: 281 ALGYAGVYSSFLRHCETAAA--RYGLSAVDILVELGKRRMVGGQEDMIV 327 A +++ T A + + LGK + + Sbjct: 298 AHASGIHQDGVIKNRRTYEALRAEDVGGRGGSIVLGKLSGTHALRNRLE 346 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 69/355 (19%), Positives = 121/355 (34%), Gaps = 23/355 (6%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQGS---- 55 M + + I D TLRDG +S IA+ L + +VD IEVA +G Sbjct: 1 MTSRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAV 60 Query: 56 -SFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 GA+ L+ IE V A I ++ G ++ L + Sbjct: 61 KKITDWAGANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEA 120 Query: 115 EADVSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++ A + G+ +L ++ E + + + I + D+ G Sbjct: 121 HFEDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLSTLPVKRILLPDTLGI 180 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + + + P+ H H++ LGVAN + A+ G + ++ GMG Sbjct: 181 LTPFESYTFIKEIVDR-YPDQHFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERT 239 Query: 232 GNAPLEVFIAAADKL--GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYA 285 GNAPL IA + L + +L + + + V Sbjct: 240 GNAPLASTIAVINDLMPECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQTAG 299 Query: 286 GVYSS----FLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L + R+G L LGK E+ + D+ + L + Sbjct: 300 IHADGDKKNNLYFSKLMPERFG---RQRLYALGKTSGKANIENNLRDLGISLSDA 351 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 107/276 (38%), Gaps = 31/276 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 I D TLRDG + +S+E I ALD A+V IE + Sbjct: 7 FEIIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAGIPAMGKQE---------- 56 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV------- 118 E ++ + L+ + DLK + G + V V+ ++ + Sbjct: 57 ----CEDLKLMLNLPIKSNLIAWNRANLEDLKASIDCGFKFVHVSLPVSDLHIEHKLQKS 112 Query: 119 -------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + ++Y + + + + PE L + A + YGA I D+ G Sbjct: 113 RTWVLDQLKKCMEYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGC 172 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ + + + P +HAH++ L VAN++AA + G ++ G+G A Sbjct: 173 LDHFTTYRKIKEIADHSPP--PVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERA 230 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVR 266 GNA +E + + + G +L AL A+ + + Sbjct: 231 GNASMEETAFSLKRFYNYDCGIELEALPFLAEMVSK 266 >UniRef50_UPI0001788D72 pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001788D72 Length = 321 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 123/270 (45%), Gaps = 7/270 (2%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ--GSSFNYGFGAH 64 I D T+RDG +S+E V+ + L++A VD +E+ + + + + G Sbjct: 8 KIVDCTIRDGGLVNNWDFSVEFVQNLYAGLNEAGVDYMEIGYKNSPKLLKGADQAGPWRF 67 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D E++ K++ L+ G D+ ++ ++RVA + + D + +Q Sbjct: 68 LDDEFLREVIPHKGKTKLSALVDIGRVDEDDILPREESLLDLIRVACYIKDVDKALALVQ 127 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 + G +T +M L + +++ +Y+VDS G+++ D+ Sbjct: 128 TFHDRGYETTLNIMALSNVMENELLEAFEMIRESVVDVVYIVDSYGSLDHKDMEYLVNKF 187 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 K L P + G+H H+N+ L +N++ A + G + +DAS+ GMG AGN P E+ + Sbjct: 188 KTHL-PNKRLGVHTHNNMQLAFSNTLVAADLGVELLDASVYGMGRAAGNCPTELLVTHLK 246 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDRPVR 274 +L ++D + + PL+++ Sbjct: 247 G----TKYELRPVLDIIERFMIPLREKEEW 272 >UniRef50_Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit n=56 Tax=Bacteria RepID=5S_PROFR Length = 505 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 59/340 (17%), Positives = 123/340 (36%), Gaps = 26/340 (7%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 +++ I+++ LRD ++ + ++E++ +D A S+E G F Sbjct: 11 PREVGITELVLRDAHQSLMATRMAMEDMVGACADIDAAGYWSVECWGGATYDSC---IRF 67 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVAT 111 E + ++ ++++ LL + + + G V RV Sbjct: 68 LNEDPWERLRTFRKLMPNSRLQMLLRGQNLLGYRHYNDEVVDRFVDKSAENGMDVFRVFD 127 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + A + ++ G G + S + T E K A + GA I + D Sbjct: 128 AMNDPRNMAHAMAAVKKAGKHAQGTICYTISPVHTVEGYVKLAGQLLDMGADSIALKDMA 187 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 + D +A+K +TQ +H H + + + A+E G D +D +++ M Sbjct: 188 ALLKPQPAYDIIKAIKDTYGQKTQINLHCHSTTGVTEVSLMKAIEAGVDVVDTAISSMSL 247 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY----- 284 G G+ P E + G+ D L D + ++ + + + +TL Sbjct: 248 GPGHNPTESVAEMLEGTGYTTNLDYDRLHKI-RDHFKAIRPKYKKFESKTLVDTSIFKSQ 306 Query: 285 --AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 G+ S+ A + +++ E+ + R G Sbjct: 307 IPGGMLSNMESQLRAQGAEDKMD--EVMAEVPRVRKAAGF 344 >UniRef50_P32327 Pyruvate carboxylase 2 n=326 Tax=cellular organisms RepID=PYC2_YEAST Length = 1180 Score = 193 bits (491), Expect = 7e-48, Method: Composition-based stats. Identities = 53/363 (14%), Positives = 112/363 (30%), Gaps = 39/363 (10%) Query: 8 ISDVTLRDGMHAI-RHQYSLENVRQIAK--ALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + D T RD ++ + ++ IA A A ++E G + F Sbjct: 560 LMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGAFALECWGGATFDVAM---RFLHE 616 Query: 65 SDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATHCT 114 E + +V + LL P H +K A G + RV Sbjct: 617 DPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALN 676 Query: 115 EADVSAQHIQYARELGMDTVGFLMMSH-------MTTPENLAKQAKLMEGYGATCIYVVD 167 + + + ++ G + S + + + + G + + D Sbjct: 677 DLEQLKVGVNAVKKAGGVVEATVCYSGDMLQPGKKYNLDYYLEVVEKIVQMGTHILGIKD 736 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G M + + +L+ P+ +H+H + VA+ A G D +D ++ M Sbjct: 737 MAGTMKPAAAKLLIGSLRTR-YPDLPIHVHSHDSAGTAVASMTACALAGADVVDVAINSM 795 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD----RETLALG 283 + +A+ + G ++ + + D ++ + + Sbjct: 796 SGLTSQPSINALLASLEG-NIDTGINVEHVREL-DAYWAEMRLLYSCFEADLKGPDPEVY 853 Query: 284 YAGVYSSFLRHCETAAARYGLS---------AVDILVELGKRRMVGGQEDMIVDVALDLR 334 + L + A + GL + LG V ++ D+A + Sbjct: 854 QHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMV 913 Query: 335 NNK 337 +NK Sbjct: 914 SNK 916 >UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT Length = 415 Score = 193 bits (491), Expect = 7e-48, Method: Composition-based stats. Identities = 64/359 (17%), Positives = 113/359 (31%), Gaps = 38/359 (10%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN +++ I DVTLRDG ++ + IA+ LD V IEV Sbjct: 32 MNLPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSG------ 85 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---- 115 D + + + AK L D+K A + GA + T Sbjct: 86 -----EDQRVFKRLSKMNLKAKKIAL---ARIMDEDVKLAAECGADGLFYETSINPYFVK 137 Query: 116 ----------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQA--KLMEGYGATCI 163 D + + A+ELG+ + K +L++ I Sbjct: 138 YVLGLDSKEFIDRIIKGAKLAKELGLFVEFCGWDTFRINNLEWIKTVYTELLKNVEVDQI 197 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G + + R +K P +H H++ L A ++ A+ G + ++ S Sbjct: 198 GISDTFGQAHPFTVNFLVRKMKE-WFPSIPLSIHVHNDYGLATATALMAIASGAEAVETS 256 Query: 224 LAGMGAGAGNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRE 278 +G GNA E IA + LG + D L + + + V Sbjct: 257 FNCLGERTGNASTEEVIAGIEMILGIKTNVDCQELYRVSKMIQEVSKMHVAPNKPIVGDR 316 Query: 279 TLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 V + + +Y + G+ G + + + Sbjct: 317 IFDSESGIVIDANEKINRATEIKYAMYP-YNPENFGRWLKYVGGKKSGRAFVKQYLDKR 374 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 193 bits (490), Expect = 9e-48, Method: Composition-based stats. Identities = 73/368 (19%), Positives = 118/368 (32%), Gaps = 50/368 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+ I D TLRDG +S+++ IA LD+ VD IE Sbjct: 29 PAKVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQ-------- 80 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC--------- 113 D I + + +KI T D+ A Q GA V + Sbjct: 81 ---DATAITEISKLGLKSKIYTF---ARAMKADIDMALQCGADGVIIEVPIGYPKLKTQF 134 Query: 114 -----TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGY-GATCIYVVD 167 SA I YA+E G+ V F + +L K + I +VD Sbjct: 135 GWTWEDVVKKSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIGLVD 194 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G I+ R L E +H H++ +GVA +AAV G + + G+ Sbjct: 195 TMGCATPEAIKYMVRWLTK--MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGL 252 Query: 228 GAGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLAL 282 G GNA LE + G+ L + + + + + Sbjct: 253 GERTGNAALEELMMGLHLLYGYDTQYKLGKIPELGALIAERSNISIARNKPVLGHGNFIR 312 Query: 283 GYA--------------GVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVD 328 G + S I+ ++G+ M ++D I Sbjct: 313 ESGIGIDYVMNDPLVMFGTHPSLTGKVGEVVLGKKSGKASIIYKMGELGMGVLEDDKIAM 372 Query: 329 VALDLRNN 336 + +++N Sbjct: 373 ILEEVKNA 380 >UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN Length = 325 Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats. Identities = 53/296 (17%), Positives = 103/296 (34%), Gaps = 37/296 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K++ I +V RDG+ ++ S ++ L +A + IE + Sbjct: 30 PKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK------WVP 83 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 D + L + + A AGA+ V + +E Sbjct: 84 QMGDHTEVLKGIQKFPGINYPVL----TPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139 Query: 117 --------DVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 ++ A+ + G+ +P +A+ K G Sbjct: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D+ G ++D A+ E+ P +H H +AN++ A++ G +D+ Sbjct: 200 ISLGDTIGVGTPGIMKDMLSAVMQEV-PLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP 272 S+AG+G GN E + + LG G +L L++A + + + L + Sbjct: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKT 314 >UniRef50_UPI0001C37344 hypothetical protein RflaF_17007 n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37344 Length = 465 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 57/345 (16%), Positives = 116/345 (33%), Gaps = 34/345 (9%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ +++ LRD ++ + + I +D A SIE G G Sbjct: 2 KKVQLTETVLRDANQSLMATRLPYADYEGILDDMDKAGYYSIECWGGATFDSCLRYLG-- 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E + + + ++ LL ++ + + G V+R+ Sbjct: 60 -EDPWERLRNLRKHLPNNRLQMLLRGQNLLGYKHYHDDVVEKFIELSIKNGIDVIRIFDA 118 Query: 113 CTEADVSAQHIQYARELGMDT-----VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + ++ ++ D S + T + + K ++ G I + D Sbjct: 119 LNDFRNIRTALEATKKYATDKTIASGCISYTQSPVHTVDKYIEMCKELKTMGFDTICLKD 178 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G M+ + + +K + + +H H + A+E G D ID + + Sbjct: 179 MAGTMSPYEAEHLIKGIKDAIG-DMTLILHTHCTTGMAYMTLTKAIESGIDVIDTATSCF 237 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD--------RPVRVDRET 279 G E A + G + G D +++ +D +P++ P + + Sbjct: 238 SGGTSQPATETMYYALKQYGIETGLD-EDVINKVNDYFKPIKQKYIDNGQLNPKSLATDA 296 Query: 280 LALGY---AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 AL Y G+ S+ + + A + L E+ K R G Sbjct: 297 QALVYKVPGGMLSNMIANLTDMHAMDKFD--EALAEIPKVRADMG 339 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 109/317 (34%), Gaps = 34/317 (10%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M K+ I+D TLR+G A ++S+ + IA ALD VD IE+ H Sbjct: 1 MQRKRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRT- 59 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA---- 116 EA A + AKI D++ + GA V + + Sbjct: 60 ----------EAVAKLGLGAKIIAH---ARAHRTDIEAVSRTGATWVGIFLGVNDITTKA 106 Query: 117 -----------DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 + A ++ A++ G++ + T L GA I Sbjct: 107 RVIGRSTTELIRMVADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICY 166 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G +++ + +K+E P+ + +H H + L +ANS+AA++ G D I S+ Sbjct: 167 ADTLGIAEPAEVARKVTLMKSEF-PDAEVEVHLHDDRGLAMANSLAAIDAGVDSISVSVN 225 Query: 226 GMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLA 281 +G G L + G + D+ L + + P V Sbjct: 226 ALGERCGITDLATLLVNLGFRGERALPDISELRALSRLVAMSSNTPFDALRPIVGDNAFK 285 Query: 282 LGYAGVYSSFLRHCETA 298 G + Sbjct: 286 HGSKLHQRATQYEPRAY 302 >UniRef50_C7MMV3 Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=4 Tax=Coriobacteriaceae RepID=C7MMV3_CRYCD Length = 634 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 120/338 (35%), Gaps = 27/338 (7%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KL + D T+RDG ++ + + ++ I A+D +IE G F Sbjct: 2 PKLQLMDTTIRDGQQSLWATRMPVGDMLPILPAMDKVGYWAIEAWGGATFDTC---LRFL 58 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 + E + + ++A L LK A + G V RV Sbjct: 59 DENPWERLRQIKAKTPNTRLAMLTRGQNLVGYKHYSRDIVNRFLKAAQRNGVDVFRVFDA 118 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + +E G G + S + T ++ + A+ ++ GA I + D G Sbjct: 119 LNDIRNVTDSAEAVKEAGGWFEGAISYTISPVHTLDSYLEYAQQLKELGADSIAIKDMAG 178 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + RAL E+ +H H+ + AN + A E G D + A + G Sbjct: 179 MLTPYRTERMVRALNDEIG--LPVHVHCHYVGGMAPANILKAAEAGAAIADTASAPLAFG 236 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY------ 284 +E+ +AA + + G DL L + A+ + + +L Sbjct: 237 NSQPAVEMIVAALQESAFSTGYDLDLLFEIAEYWEEVRRRTHHKRGVSSLTHMKVYSHQV 296 Query: 285 -AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + E A + D++ E+ K R G Sbjct: 297 PGGMMSNLMAQLEVQNAADRID--DVMREIPKVRAEVG 332 >UniRef50_C0CVP8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVP8_9CLOT Length = 336 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 64/340 (18%), Positives = 132/340 (38%), Gaps = 10/340 (2%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K+++ D TLRDG + ++ ++I L + + IE+ + Sbjct: 1 MN--KIHLLDCTLRDGGYVNNWEFDNGVAKEIVNGLYKSGIHVIEIGIMGHGGKVGKSTK 58 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F + + E + + K K A +L D+ + ++R+A +E + Sbjct: 59 FASFKEAESLLE--NRKKDCKYAIMLNQAEAASFDIPARSEKTVDMIRLAYFKSEFQNAI 116 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 + ++ G + M + M + + + + + Y+VDS + DI Sbjct: 117 VLAKSLKDKGYEVFLQAMATFMYSDDEMNDMLRQINDMKPKAFYIVDSFSNLFPEDIARM 176 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLE 237 + + +L + G HAH+N+ + +N+I ++ DR ID S+ GMG GAGN P+E Sbjct: 177 AKQVLLKLDKDIDFGFHAHNNIQMAFSNAITFMDVESDRDIYIDGSIYGMGRGAGNVPIE 236 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP-VRVDRETLALGYAGVYSSFLRHCE 296 + + +K + +L L+ D ++P+ ++ + S + + Sbjct: 237 LLMDYLNKK--EKLYNLEVLLKTYQDYIKPIFEQYFWGYTHPYYLTASKDMNSVYSWYFM 294 Query: 297 TAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 + L + +D +V +R Sbjct: 295 NNGINDIVRLNKALDMISDDSKYALMKDEASEVVKKIRGE 334 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 100/256 (39%), Gaps = 31/256 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M KK YI D TLRDG + +S ++AK +DDA + IE Sbjct: 1 MKEKK-YIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAGIPAMGNY------ 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-- 118 + E I K+A I+T + D+ N++ ++ + + + Sbjct: 54 -----EKETISEIMSQRKNALIST---WNRMSRDDINNSFDCHPDIIHITAPISYIHIYS 105 Query: 119 ------------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 + + A++ G + + + A L+ G + Sbjct: 106 KLNKNKKWLRNTLQECVFMAKDKGYEVTVGFEDASRADITFIISMANLLADMGVKSVRFA 165 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G + + R +K + + G+HAH++L + +ANS+ A + G ID ++ G Sbjct: 166 DTVGVLTPARTYQCIREIKENV--DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGG 223 Query: 227 MGAGAGNAPLEVFIAA 242 +G AGN L FI A Sbjct: 224 IGERAGNCDLYQFILA 239 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 67/359 (18%), Positives = 111/359 (30%), Gaps = 40/359 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M Y+ D TLRDG A +SL + IA L + IEV + Sbjct: 1 MYPDNRYLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVGIPAMGE------- 53 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV-- 118 + + I A + + +I T G DL+ A ++GA + + + Sbjct: 54 ----CERQHIRAISQLDLDCRILT---WGRAVREDLRAASKSGADGFHFSLPASPLHLRI 106 Query: 119 --------SAQHIQYARELGMDTVGF---LMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + A+E F + + L + GA+ + + D Sbjct: 107 WKKNERWVLRTMSELAKEAADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIAD 166 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G +N D D F + HAH++L + VAN+++A G ++ G+ Sbjct: 167 TTGRLNPIDTLDLFCDITKNAS--IDLEFHAHNDLGMAVANTVSAFIGGATCASVTVNGL 224 Query: 228 GAGAGNAPLEVFIAAA-DKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLAL 282 G AGNA LE A D +D + R L + Sbjct: 225 GERAGNAALEEVSMALKHSTDIDIPMDASHYYKLSDYVANASQRRLAWNKPVTGPGAHSH 284 Query: 283 GYAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 L + G S + +G+ + L K Sbjct: 285 ESGIHCKGLLTDSRSYETVSPEEIGQSRPEF--AIGRHSGSAAVIAAAQKLGHTLSAKK 341 >UniRef50_Q7U935 Possible HMGL-like family protein n=1 Tax=Synechococcus sp. WH 8102 RepID=Q7U935_SYNPX Length = 540 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 68/342 (19%), Positives = 129/342 (37%), Gaps = 29/342 (8%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDG----LQGSSF 57 N + I D TLRDG + +S E + +A A++D IE+ +G+ Sbjct: 3 NERTFKILDCTLRDGGYYNNWNFSDELIENYVRASLAAKIDVIEIGFRSSLNNKFKGACA 62 Query: 58 NYGFGAHSDLEWIE--AAADVVKHAKIATLLLPGIGTIHDL-KNAWQAGARVVRVATHCT 114 +L ++ A +V ++I K A + +VR+A H + Sbjct: 63 YSSDLFLENLPFLNGTDIAVMVNGSEICRTDSIPRLLEKLFPKPAISSIVSIVRIACHFS 122 Query: 115 EADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNM 174 E ++ + G +M ++ + + +Y DS G++ Sbjct: 123 ELSRVLSATRWLADHGYKICINIMQISDRKYADIKEITSMASDCPIDVLYFADSTGSLKP 182 Query: 175 SDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNA 234 DI + + + G+H H+N+ + + N++ A EEG + +D++++GMG G GNA Sbjct: 183 DDISRIVEWFRTGW--QRELGIHTHNNMGIALQNTLRAYEEGVNWLDSTVSGMGRGPGNA 240 Query: 235 PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRH 294 E + + L + LM + + D+ G+ +L Sbjct: 241 KTEELVIETETL-RDGNVNYVPLMALSR----------QKFDKLKAQYGWGPHPYYYLS- 288 Query: 295 CETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 +YG+ I + R ED+I V L++ Sbjct: 289 -----GKYGIHPSYIQEMINDARYD--DEDIIA-VTNQLKSE 322 >UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=47 Tax=root RepID=HMGC2_DANRE Length = 335 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 55/294 (18%), Positives = 96/294 (32%), Gaps = 37/294 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I +V RDG+ + E Q+ L + IE + + Sbjct: 43 VKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSK------WVAQMA 96 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 D + + L I + A AGA V V +E Sbjct: 97 DHTAVLKGIKRSPDVRYPVL----TPNIQGFQAAVAAGANEVAVFGSASETFSRKNINCS 152 Query: 116 ----ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATCIYV 165 Q + A++ G+ G+ P + K AK + G + + Sbjct: 153 IEESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSL 212 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G + + + E+ +H H + N + A++ G +DAS+A Sbjct: 213 GDTIGVGTAGSMAEMLSDVLTEVPAGA-LAVHCHDTYGQALPNILIALQMGVSVVDASVA 271 Query: 226 GMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPV 273 G+G GN E + LG + G DL +M+A D + + L + Sbjct: 272 GLGGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGDFICKALNRKTN 325 >UniRef50_B1ZXN8 Pyruvate carboxylase n=5 Tax=Bacteria RepID=B1ZXN8_OPITP Length = 1165 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 117/366 (31%), Gaps = 38/366 (10%) Query: 1 MNGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALD--DARVDSIEVAHGDGLQGSSF 57 + K+L I+D TLRD ++ + ++R +A AL + S+E+ G + Sbjct: 522 LKQKRLLITDTTLRDAHQSLMATRVRTYDMRAVADALAHHAPGLFSLEMWGGATFDTAM- 580 Query: 58 NYGFGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVV 107 F + + V + LL P +++A AG + Sbjct: 581 --RFLYEDPWDRLRQLRAAVPNICFQMLLRGANAVGYTNYPDHVVAGFVRHAASAGMDIF 638 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYG 159 R+ ++ ++ + + + + K A+ +E G Sbjct: 639 RIFDSLNYLPNLRVAMEAVQDTHAVCEAAICYTGDILDGKRDKFSLQYYVKLARELERMG 698 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 A + + D G +AL+ E+ H H + + + A + G D Sbjct: 699 AHFLAIKDMAGLCRPYAAYKLVKALREEIG--LPIHFHTHDTSGIAATSVLRASDAGVDV 756 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADD---LVRPLQDRPVRVD 276 +D ++A M L +AA DL L +D + + Sbjct: 757 VDLAIASMSGSTSQPNLNSIVAALQHTPRDPQLDLERLNAVSDYWEHVREFYRPFDTAPK 816 Query: 277 RETLALGYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMIV 327 + + + + + AA G+S ++ G V ++ Sbjct: 817 TGSAEVYLHEMPGGQYTNLKEQAASMGVSHRWPEIARTYAEVNQLFGDIVKVTPSSKVVG 876 Query: 328 DVALDL 333 D+AL L Sbjct: 877 DLALFL 882 >UniRef50_Q88LY5 Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK Length = 534 Score = 191 bits (486), Expect = 3e-47, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 134/338 (39%), Gaps = 35/338 (10%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 D TLRDG + +S + Q A+ A + +IE+ L+ SSF+ +D Sbjct: 4 LDCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELG-LRSLKNSSFSGACAYTTD-- 60 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHDLKN----------AWQAGARVVRVATHCTEADV 118 + D+ I ++ + A ++ +VR+A H E Sbjct: 61 AFLSTLDLPPSMTIGVMVNGSELVGKNAGQQALQLLFPSPASESPVDLVRIACHVHEFAE 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + + +E G D LM + + AKL Y +Y DS G+M+ D Sbjct: 121 ALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAA 180 Query: 179 DRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEV 238 + L++E + G+H H NL L ++N++ A++EG +D+++ GMG G GNA E Sbjct: 181 QIIQWLRSEW--QGALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEE 238 Query: 239 FIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETA 298 + +L LM + +P+Q + L Sbjct: 239 LAIEIAARTRKP-ANLIPLMTLLREHFKPMQVKYGWGTNPYYYL---------------- 281 Query: 299 AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 A +YG+ I LG R G+ED++ + LRN Sbjct: 282 AGKYGIHPTYIQEMLGDSR--FGEEDILAVIEY-LRNE 316 >UniRef50_B4U857 Oxaloacetate decarboxylase alpha subunit n=10 Tax=cellular organisms RepID=B4U857_HYDS0 Length = 619 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 69/339 (20%), Positives = 126/339 (37%), Gaps = 29/339 (8%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +KLY +DV+LRDG+ ++ + E++ + LD S+EV G + Sbjct: 2 EKLYFTDVSLRDGIQSLLATRVRTEDMLPALEILDKCGFWSLEVWGGATFD---VCLRYL 58 Query: 63 AHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVATH 112 E ++ ++ K+ K+ LL P +K ++ G V R+ Sbjct: 59 KEDPWERLKQFKNITKNTKLEMLLRGQNIVGYRNYPDDVVEAFVKKSYDNGVEVFRIFDA 118 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + I+ + L G L S + T E K AK + G I + D G Sbjct: 119 LNDVRNMRKAIETGKSLNAIVKGVLSYTTSPVHTVEYYVKIAKDLVNMGIDIISIKDQSG 178 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + D +ALK E K +H L + + A+E G D + + + Sbjct: 179 ILTPKMAFDLVKALKQEFK--LPIHIHTQTTAELANMSQLKALEAGATMFDTAFYSLSSQ 236 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP------VRVDRETLALGY 284 + E I + G+Q D AL + A ++ R ++ + ++ Sbjct: 237 TSHPSGETMIHVFKEFGYQIDVD-QALYEEAGNVFREVRKKYKKYDTLPPYPDVSVLTHQ 295 Query: 285 --AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+F+ + L ++L E+ + R G Sbjct: 296 VPGGMISNFISQLKEQNLEDKLE--EVLKEVARVREDLG 332 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 113/326 (34%), Gaps = 35/326 (10%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 + +L++ D TLRDG A +S + IA+AL +ARV +EV G+ Sbjct: 5 SPHRLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVGIPAAGAGA------ 58 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA- 120 ++ I A AD V A ++ D+ A V ++ + + Sbjct: 59 -----IDDINAVADAVAGR--ARIITWCRALPGDIALARACRVTGVHLSFPVSNIHMRIW 111 Query: 121 ------------QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + ARE + P LA+ A A + + D+ Sbjct: 112 GATPATVLASLDELTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADT 171 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + L+ P +HAH++L L AN++AA G ++ G+G Sbjct: 172 VGFLTPDKTAGLTSHLRHA-APALPVEIHAHNDLGLATANTLAAFSAGASAASLTVNGLG 230 Query: 229 AGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALG 283 AGNA LE + A G G D ++ + + RP+ + V Sbjct: 231 ERAGNAALEEVVMALKVAQGIDCGIDTSRFVELSALVARASRRPVPVQKPVVGAGAFLHE 290 Query: 284 YAGVYSSFLRHCETAAARYGLSAVDI 309 + LR + D+ Sbjct: 291 SGIHCAGLLRDRRSYEP---FDPADV 313 >UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH Length = 391 Score = 190 bits (484), Expect = 4e-47, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 119/350 (34%), Gaps = 43/350 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + + D TLRDG ++ R IA+AL A V +EV + Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGE-----------E 67 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 + I A A V+K A ++ DL A + G + + +E Sbjct: 68 ERADIRAVAAVLKTA---APVVWCRLRAEDLAAAQRTGVVRLHIGVPVSERQISAKLGKD 124 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 D + ++ A G + P LA+ A + GA + D+ G Sbjct: 125 AAWVRDKVEKLVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGV 184 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 ++ + + H H++L + ANS+AA G + ++ G+G A Sbjct: 185 LDPFAAHELVGRVVTRCP--LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERA 242 Query: 232 GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 GNA LE AA + G G L L ++ + RPL + V Sbjct: 243 GNAALEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIH 302 Query: 288 YSSFLRHCETA------AARYGLSAVDILVELGKRRMVGGQEDMIVDVAL 331 ++ T R+G S + +GK G + + L Sbjct: 303 VDGLMKDRATYESADLRPERFGRSHR---IAIGKHSSAAGLARALAEAGL 349 >UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN Length = 370 Score = 190 bits (483), Expect = 5e-47, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 105/294 (35%), Gaps = 37/294 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + I +V RDG+ + + + L + IEV + Sbjct: 75 PEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSR------WVP 128 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD----- 117 +D + + L + +A AGA + V +E+ Sbjct: 129 QMADHTEVMKGIHQYPGVRYPVL----TPNLQGFHHAVAAGATEISVFGAASESFSKKNI 184 Query: 118 ---------VSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 + ++ AR + + G+ TP+ + + +K + G G Sbjct: 185 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 244 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D+ G ++ ++ E+ P +H H +AN + A++ G + +D+ Sbjct: 245 ISLGDTIGVGTPGSMKRMLESVMKEIPPGA-LAVHCHDTYGQALANILTALQMGINVVDS 303 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 +++G+G GN E I + LG G +LY +M+A D + + + Sbjct: 304 AVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNK 357 >UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5 Length = 377 Score = 190 bits (483), Expect = 5e-47, Method: Composition-based stats. Identities = 57/358 (15%), Positives = 113/358 (31%), Gaps = 39/358 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+ I D TLR+G ++ +IA+ L DA V IE H Sbjct: 2 PLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYS----- 56 Query: 63 AHSDLEWIEAAADVVKHAKI-ATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEAD---- 117 I+ D+ I + ++ D+ +A G + + ++ Sbjct: 57 ------AIKEIMDMKASGMINSEIIAHSRAVNSDIDSAASLGVDRIAIFYGVSDIHLDNK 110 Query: 118 ----------VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVD 167 + I YA G+ + T L + GA + + D Sbjct: 111 THRSRTEALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIAD 170 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 + G + F L + H H+++ + +AN +AA E G I +++ G+ Sbjct: 171 TLGILTPEKTAYIFNNLSD--IKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGL 228 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRP----LQDRPVRVDRETLALG 283 G G P + + +L +L ++ + + + Sbjct: 229 GERVGIIPTQALGVLLNYHLGVDAINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTHK 288 Query: 284 YAGVYSSFLRHCETA----AARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK 337 +R+ T +R GL + K + + ++ ++ +NK Sbjct: 289 SGVHVDGIIRNPGTYEFMDPSRLGLQHS---FTIDKYSGKHALREKLANMGINADDNK 343 >UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI Length = 311 Score = 190 bits (483), Expect = 6e-47, Method: Composition-based stats. Identities = 52/289 (17%), Positives = 101/289 (34%), Gaps = 39/289 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 KK+ + +V RDG+ ++ + Q +AL +A + +E+ + Sbjct: 17 PKKVTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTSFVSPK------WVP 70 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 D A+++V+ + + + + + V V + + Sbjct: 71 QMKD------ASEIVESCLNSERDIVLAPNRKGVDRVLETKGKAVAVFVGVSNSFNKKNI 124 Query: 117 --------DVSAQHIQYARELGMDTV------GFLMMSHMTTPENLAKQAKLMEGYGATC 162 + + +E G + P+ + + G Sbjct: 125 NKTTAESLEELKPIVGELKEKGYFVRACISTSFYCPYEGKIPPQETLQLCREFVDMGVDE 184 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + V D+ G N + + F LK L PE H H + +AN +A+++ G DR D Sbjct: 185 LSVADTIGMANPKESFELFSLLKKTL-PEVLMTAHFHDTRKMALANILASLQAGVDRFDT 243 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV 265 S G+G GNA E + ++G + G DL +L A + + Sbjct: 244 SAGGLGGCPFAPGASGNAATEDVVFMLHQMGIETGVDLDSLTAAVNLVA 292 >UniRef50_B0TK18 Oxaloacetate decarboxylase alpha subunit n=37 Tax=Bacteria RepID=B0TK18_SHEHH Length = 603 Score = 190 bits (483), Expect = 6e-47, Method: Composition-based stats. Identities = 63/343 (18%), Positives = 120/343 (34%), Gaps = 33/343 (9%) Query: 3 GKKLYISDVTLRDGMHA-IRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 K L ++DV LRD + + + E++ IA LD S+E G++F+ Sbjct: 2 SKPLALTDVALRDAHQSILATRLRTEDMLPIAPLLDKVGFWSLE-----SWGGATFDSCI 56 Query: 62 GAHSDLEW--IEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRV 109 + W I V+ + LL ++ A G V RV Sbjct: 57 RYLGEDPWERIRELKKVMPNTPQQMLLRGQNLLGYRHYADDLVHRFVERAHTNGVDVFRV 116 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVD 167 + ++ E+G G + S + AK +E G + + D Sbjct: 117 FDAMNDVRNLETAVKAVVEVGGHAQGTISYTTSPVHNLNTWIDMAKRIEDMGCHSLCIKD 176 Query: 168 SGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGM 227 G + + + +K++ + +H H L A A+E G D +D +++ M Sbjct: 177 MAGLLKPFEAFELISQIKSQ--TDLVLSLHCHATTGLSTATYQKAIEAGIDVLDTAISSM 234 Query: 228 GAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY--- 284 G++ E +A + G D+ AL++ R ++ + + E + Sbjct: 235 SQTYGHSATETLVAMVEGTDRATGYDM-ALLEEIAAYFRTVRKKYAAFEGELKGIDSRIL 293 Query: 285 -----AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQ 322 G+ ++ + A L +L E+ + R G Sbjct: 294 RAQVPGGMLTNMESQLKEQGAADKLD--LVLEEIPRVREDLGF 334 >UniRef50_A6L7H4 Putative 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Bacteroides vulgatus ATCC 8482 RepID=A6L7H4_BACV8 Length = 525 Score = 190 bits (482), Expect = 7e-47, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 127/335 (37%), Gaps = 7/335 (2%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ + D TLRDG + ++ +R+I + L A +D +E + + F A Sbjct: 3 KIQLLDCTLRDGGYINNFRFGKYAIRKILQQLTHAGLDIVECGFLEDGEYDEDTSIFNAA 62 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 + + + ++ G + L + +RV H E + + ++ + Sbjct: 63 EQIASL--LPNEHGRTMFVAMVCYGEYDLSQLSPCTRNSIDGIRVTFHYDEVEGALEYCR 120 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 +E G + + T L + + Y+VD+ G M+ +DI F + Sbjct: 121 EIKEKGYKVFVQPVGTSSYTDIQLLHLIEKVNELQPYSFYLVDTLGLMHKNDIARFFYLI 180 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI---DASLAGMGAGAGNAPLEVFIA 241 L G H+H+NL L +NS E DR+ DAS+ GMG GAGN E+ Sbjct: 181 NTNLDKSINMGFHSHNNLQLSFSNSQEFFEYVGDRVISLDASIYGMGRGAGNLNTELIAN 240 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQDRP-VRVDRETLALGYAGVYSSFLRHCETAAA 300 + H + L++ D+ + ++ + G + ++ + Sbjct: 241 YVNDREG-HMYAIEPLLEVVDEFIIHIRQKHEWGYTVPYYLAAINGCHPNYASYLAQKQT 299 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 IL + + ++++ + L+ ++ Sbjct: 300 LAVKEISAILHMIPVEKRSLYNKELVNRIYLEYQS 334 >UniRef50_B0MS84 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MS84_9FIRM Length = 528 Score = 190 bits (482), Expect = 8e-47, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 124/332 (37%), Gaps = 8/332 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K++ I D TLRDG + ++ EN++ + L A +D IE + F+ Sbjct: 2 KRIRILDCTLRDGGYINNWKFGYENIKDTVRRLIQAGIDIIEAGYLSSKG--DFSADESQ 59 Query: 64 HSDLEWIEAAADV-VKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +S ++ I+ K+ IA ++ G L G +RV H ++A + + Sbjct: 60 YSSVDAIKRILPADRKNTLIAVMINCGDYDAELLPQYDGTGPDCIRVCFHKSQALQAVEL 119 Query: 123 IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFR 182 + +E G M++ + + + Y+VDS G+M D+ F Sbjct: 120 CRKIKEKGYKVYFQPMVALSYSDAEYLGLIGMANKFRPDGFYIVDSHGSMKQKDVARFFY 179 Query: 183 ALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEVF 239 ++ L E G H+H+NL L +N+ D ID+S+ GMG GAGN E+F Sbjct: 180 LIENNLDKEIAVGFHSHNNLQLSYSNAQYLTALHTDHNLIIDSSIMGMGRGAGNLNTELF 239 Query: 240 IAAADKLGWQHGTDLYALMDAADDLVRPL-QDRPVRVDRETLALGYAGVYSSFLRHCETA 298 + ++ ++ + D+ + + + ++ R Sbjct: 240 VEYLNETAG-ADYSTEPILCSIDNTIARIYMTTAWGYSLSGYLSAKYRCHQNYARFLNNK 298 Query: 299 AARYGLSAVDILVELGKRRMVGGQEDMIVDVA 330 I ++ + + I + Sbjct: 299 NTLTFEGMNAIFSKIEPEKRDNYDREYIDKLY 330 >UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, putative, expressed n=8 Tax=cellular organisms RepID=Q2RAU5_ORYSJ Length = 387 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 53/296 (17%), Positives = 104/296 (35%), Gaps = 37/296 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + I +V RDG+ + ++ L + + +E + Sbjct: 90 PRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATSFVSPK------WVP 143 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 +D + + V + L + + A AGA+ V V +E+ Sbjct: 144 QLADAKDVLQGIRHVPDVRFPVL----TPNLRGFEAALAAGAKEVAVFASASESFSKSNL 199 Query: 117 --------DVSAQHIQYARELGMD------TVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 + A++ GM V + P +A AK + G + Sbjct: 200 NCTIKESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCSE 259 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D+ G I A+ + + + + +H H +AN + +++ G + +D+ Sbjct: 260 ISLGDTIGVGTPGSILAMLEAVMSFVPVD-KLAVHFHDTYGQALANILVSLQLGINIVDS 318 Query: 223 SLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP 272 S++G+G GN E + LG + DL LMDA D + + L + Sbjct: 319 SVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQS 374 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 67/340 (19%), Positives = 120/340 (35%), Gaps = 27/340 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +++ I D TLRDG + E+ +IA+ALD+ V IE + Sbjct: 30 RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERAR 89 Query: 64 HSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 H A V + + LL + + A RV+ T Sbjct: 90 HQQWRHARITAFGSTRRAGGTVEEDVNLRLLLEAETPAVTIVGKASPFQVRVILGTTLDE 149 Query: 115 EADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A+ + + + G + + + P+ + GA + + D+ G Sbjct: 150 NLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALAVLRAACDAGADAVVLCDTNGG 209 Query: 172 MNMSDIRDRFRALKAELKP-ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 RA++ L G+H H++ L VAN+IAAV G + ++ G+G Sbjct: 210 TL---TDPLVRAVRHALSSVSCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGER 266 Query: 231 AGNAPLEVFIAAA-DKLGWQHGT--DLYALMDAADDLVR---PLQDRPVRVDRETLALGY 284 GNA L I KLG++ +L L + + + D + Sbjct: 267 IGNANLCSIIPILEYKLGYRCLPPGNLRKLTETSRYVAEVANLAHDPRLPFVGAFAFTHK 326 Query: 285 AGVYSSFLRHCETA-----AARYGLSAVDILVELGKRRMV 319 AG++ + + +A G + ++ EL R + Sbjct: 327 AGLHVNAIAKHPSAYEHIPPEVVGNTRHVLVSELSGRSNI 366 >UniRef50_C8P007 Oxaloacetate decarboxylase, alpha subunit n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P007_ERYRH Length = 465 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 126/338 (37%), Gaps = 24/338 (7%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + + I+DVT+RDG ++ + E++ +I +D +++IEV G G+ + Sbjct: 2 QTIKINDVTVRDGNQSLLATRMEHEDILKILAEMDQVGLNAIEVWGGATFDGALRFFKRS 61 Query: 63 AHSDLEWIEAAAD------VVKHAKIATLLLPGIGT-IHDLKNAWQAGARVVRVATHCTE 115 +L ++ A +++ I T ++ + + G ++RV + Sbjct: 62 PWQNLRDMKRVAPNTPFSMLLRGQNIVGYHHYDNDTLERFIRLSLENGIDIIRVFDALND 121 Query: 116 ADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 + I + ++ G G + S + + AK + G+ I + D G + Sbjct: 122 IENVKNAIYFIKKHGGHCQGAISYTVSPVHNIDYYVTYAKQLVEAGSDSICIKDMAGILL 181 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 + + LK EL + +H+H L A++ G D +D ++ G + Sbjct: 182 PDVTFELVKRLKEEL--DVPINLHSHATTGLSSLVFEQAMKAGVDIVDGCISPFSNGTSH 239 Query: 234 APLEVFIAAADKLGWQHGTDLYAL---MDAADDLV-RPL----QDRPVRVDRETLALGY- 284 LE + A + AL + A++L + + + + Sbjct: 240 IALETLLETAHVTNRETTLTHTALQGAYEEANELATKYIASGQYPAKALMINPNILTYQV 299 Query: 285 -AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+ + + A ++L E+ K R G Sbjct: 300 PGGMLSNLMSQLKDQGASDRYE--EVLKEIPKVREDLG 335 >UniRef50_A6UE85 Pyruvate carboxylase n=111 Tax=Bacteria RepID=A6UE85_SINMW Length = 1184 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 61/364 (16%), Positives = 112/364 (30%), Gaps = 32/364 (8%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDA--RVDSIEVAHGDGLQGSSFNY 59 K++ I+D T+RDG ++ + ++ +IA A + S+E G S Sbjct: 568 RKEVLITDTTMRDGHQSLLATRMRTYDIARIADTYARALPGLFSLECWGGATFDVSMRFL 627 Query: 60 GFGAHSDLEWIEAAAD------VVKHAKIATLLL-PGIGTIHDLKNAWQAGARVVRVATH 112 L + A +++ A P + ++ A + G V RV Sbjct: 628 TEDPWERLAMVREGAPNLLLQMLLRGANGVGYKNYPDNVVKYFVRQAAKGGIDVFRVFDC 687 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGATCIY 164 + + E + + + A +E GA I Sbjct: 688 LNWVENMRVSMDAVAEENRICEAAICYTGDILNSARPKYDLKYYTALAAELEKAGAHMIA 747 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 V D G + + R F+ALK + H H + A +AAVE G D +DA++ Sbjct: 748 VKDMAGLLKPAAARVLFKALKEA--TDLPIHFHTHDTSGIAAATVLAAVESGVDVVDAAM 805 Query: 225 AGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRETLA 281 + L + A G D + + + + + Sbjct: 806 DALSGNTSQPCLGSIVEALSGSERDPGLDPEWIRRISFYWEAVRHQYAAFESDLKGPASE 865 Query: 282 LGYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMIVDVALD 332 + + + + A GL D G V ++ D+AL Sbjct: 866 VYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADANRMFGDIVKVTPSSKVVGDMALM 925 Query: 333 LRNN 336 + + Sbjct: 926 MVSQ 929 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 64/353 (18%), Positives = 121/353 (34%), Gaps = 31/353 (8%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG-- 62 K++ D TLRDG +S+++ IA+ LDD +D IE + Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGE 61 Query: 63 ------AHSDLEWIEAAADVVKHAK-IATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 + A + V+ + + L+ G + +W R + Sbjct: 62 LNLKHSKLTAFGSTRFAKNPVEEDRNVKALVEAGTPVVSIFGKSWDLHVRRALGISLEEN 121 Query: 116 ADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + + Y G + V + P+ + + GA+ + + D+ G Sbjct: 122 LVLISDTVGYIHGHGREVVYDAEHFFDGYTADPDYALRTLEAAHKAGASVLCLCDTNGGT 181 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + ++ + G+H H++ L VAN+IAAVE G + + G G G Sbjct: 182 VTGRLVEIVAEVRKRF--DGIIGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGERCG 239 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAA--DDLVRPLQDRPVRVDRETL----ALGYAG 286 NA L IA + L + + L + P+R D+ + G Sbjct: 240 NANLASVIANLELKLGHTTVGPEKLAGLSSTCRFIAELANLPLRNDQPFVGKSAFAHKGG 299 Query: 287 VYSSFL-----RHCETAAARYGLSAVDILVELGKRRMV------GGQEDMIVD 328 V+ S + + G ++ +L R + G D + + Sbjct: 300 VHVSAVLKDSATYEHIKPEAVGNRQRVLVSDLSGRGNIIYKLKQHGLADRLEE 352 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 106/291 (36%), Gaps = 35/291 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I +V RDG+ + + S+E ++ + + + IE + A + Sbjct: 13 VEICEVGPRDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKK------LVPAMA 66 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D E + AA + +IA L L + + A Q V+ + ++A + Sbjct: 67 DAEEVMAAWHRREGVRIAGLAL----SRSGITRALQTPIDVLHITISASDAFNKRNANKT 122 Query: 126 ARE-------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 E + T S E + + GAT + + Sbjct: 123 VAEGLSDLLPVVGEASTHLPVVTVISTSFGCPFSGDVQMETVFSVCESFLKAGATEMVLA 182 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G N + + R + G+H H+ LG+AN++A + G R D+++ G Sbjct: 183 DTTGMANPRQVAETVRGFYRTFGEDIPLGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGG 242 Query: 227 MGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDR 271 +G GN E + ++G GTDL L+ A + + + R Sbjct: 243 LGGCPFAPKATGNICTEDLVHMFHEMGIDTGTDLDGLITLAQQVEKWMGKR 293 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 56/313 (17%), Positives = 109/313 (34%), Gaps = 35/313 (11%) Query: 6 LYISDVTLRDGMH-AIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I D TLR+G A +S E +IAK L +D IEV H Sbjct: 2 VQIVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVS------------ 49 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE--------- 115 +E + ++V + + ++ + D++ + A+ V + E Sbjct: 50 --IEQKQIVREIVA-SNLCPVIAHARANLADIEAVKETSAQWVGIFLGINEETRLTRARW 106 Query: 116 -----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + + + YA+ LG+ + T L + GA CI D+ G Sbjct: 107 TISKIFNCIKESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVG 166 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 M +++ + LK++ +H H++ L +AN++AA + G +RI +S+ G+G Sbjct: 167 IMEPNEVTETIEKLKSDFST-VPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGER 225 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 G + G + + + + P+ Sbjct: 226 CGITDTLGLLVNLYYKGLRSLPSGEIIQRTSKYVAAFSRYPVNFNQPISGGNAFIHTAHL 285 Query: 287 VYSSFLRHCETAA 299 + R + + Sbjct: 286 HQKAVKRDPSSYS 298 >UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE Length = 312 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 99/289 (34%), Gaps = 34/289 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + +++V+ RDG I E I + + + V +IEV + Sbjct: 15 VTLTEVSPRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVTSFVSPKA------IPQMK 68 Query: 66 DLEWIEA-AADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 D + A + K+ ++ I + + A G R V + + Sbjct: 69 DAAIVAEYAVAMAKNTD--VNIMALIPNVKGAERALSCGIRKVNYIISASPLHNKKNMNR 126 Query: 125 YARE------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 +E LG+ T +++ + G + Sbjct: 127 TPQESFEALCELKKNFPEADVTLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSFTLC 186 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G N + +K + Q +H H+ + +AN AA+ +G DR ++++ G Sbjct: 187 DTIGVANPRQVETLLHEVKKNFS-DIQLALHLHNTHGMALANIYAAMLQGVDRFESAIGG 245 Query: 227 MG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ 269 +G AGNA E + +++ DL L+D A+ + + Sbjct: 246 LGGCPFAPGAAGNAATEDLVNMLNRMEINSNIDLAKLLDVANQIRELVP 294 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 109/316 (34%), Gaps = 36/316 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++++ D TLRDG +S E +A ALD V+ IE Sbjct: 2 PQVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMG----------- 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 + + + A A++ D++ + GA ++++ ++ + Sbjct: 51 VDEQKAVRAVLGAGLRARVLA---WNRAHPSDIEASLACGATCLQISFPVSDIHLQHKLG 107 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + A G + + P L AK E GA + D+ Sbjct: 108 RTRSWLLARLEEVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTV 167 Query: 170 GAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGA 229 G ++ RD L +L HAH++ + AN++AAV+ G +D ++ G+G Sbjct: 168 GVLDPFRSRDAVSDLTHKL--NIPLEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGE 225 Query: 230 GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYS 289 AGNA L + + + + + + VR + Y Sbjct: 226 RAGNASLSAVARGLRQFYG-----MEVVREETELAMLEGWVNSVRKRAAFFSRDYGLTLG 280 Query: 290 SFLRHCETAAA-RYGL 304 +F R RY L Sbjct: 281 AFNRALRNGEQTRYRL 296 >UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VQL9_NAEGR Length = 422 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 102/304 (33%), Gaps = 37/304 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 + I +V RDG+ + + L +A + S+EV + Sbjct: 76 PSFVKIVEVGPRDGLQNEKKLVPTNVKISLIDKLTEAGLPSVEVTSFVSPK------WVP 129 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA-- 120 D + + L + L+ A +AG + V + ++A Sbjct: 130 QMGDNFDVFTGIKRREGTAYPVL----TPNVKGLEQALEAGVKEVAIFLAASDAFSMKNI 185 Query: 121 ------------QHIQYARELGMD------TVGFLMMSHMTTPENLAKQAKLMEGYGATC 162 Q ++ A + + V S +PE +A+ + + G Sbjct: 186 NCTVEESFKRYDQVMELAIKNDLKIRGYVSCVAGCPYSGYVSPETVAQVSYRLLKMGCYE 245 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D+ G + + ++ Q +H H+ ++N + +++ G + +D+ Sbjct: 246 VSLGDTIGVGTPGSVSMLLHQVCKKIPTG-QIAVHFHNTYGQALSNILTSLQFGVETVDS 304 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD 276 S+AG+G GN E + +G G DL L+DA D + L Sbjct: 305 SVAGLGGCPYAKGASGNISTEDVVYMLHGMGINTGVDLDKLIDAGDYISTYLNRENNSKV 364 Query: 277 RETL 280 + Sbjct: 365 GLAV 368 >UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PWR8_9CLOT Length = 303 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 55/291 (18%), Positives = 107/291 (36%), Gaps = 34/291 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G ++ + +V RDG+ +++ E ++ K L DA + +E+ + Sbjct: 4 GDRIKVVEVGPRDGLQNLKNWIPTEVKIKLIKDLIDAGIKEMEMTSFVHPKA------IP 57 Query: 63 AHSDLEWI-EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 D E + +A D + +I T + + K A+ G R + +E A Sbjct: 58 QMKDAEAVTKAVIDELNEKEIRTF--ALVPNLVGAKKAYGCGLREITYVISASEKHNLAN 115 Query: 122 HIQYAR------------------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 + + L + T + + + E G I Sbjct: 116 INRTVQQSLEGLADIRAELPDIQIRLDVATAFGCPFMGQVGEDLVINLIRSAEKIGINTI 175 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N + + + + E + G+H H +G+AN +AA+E G + S Sbjct: 176 TLCDTIGIANPKQVYELSQKVSKEFQ-NIPVGLHLHDTRGMGIANYLAAIEAGISVFETS 234 Query: 224 LAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 + G+G AGN E + +++ + DL AL+ + +L L Sbjct: 235 IGGLGGCPFAPGAAGNTATEDLVNMLNEIKVETNIDLNALVSISKELEEKL 285 >UniRef50_C6LKZ4 Putative uncharacterized protein n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LKZ4_9FIRM Length = 534 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 73/340 (21%), Positives = 130/340 (38%), Gaps = 11/340 (3%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 MN K I D TLRDG + ++ ++ I L+DA VD IE SS + Sbjct: 14 MNTTK--ILDCTLRDGGYINNWKFGGRTIKSIISNLEDAGVDIIECGFIRKEDHSSDSSV 71 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA 120 F + + I A + A ++ + GA ++R+ E + + Sbjct: 72 FSSMEQVADI--IAPKKANISYAIMIEQHNHVDKLIPENDGNGADIIRITFRRKEWEEAK 129 Query: 121 QHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDR 180 I++ G + + E+L K K + Y+VD+ G M D+R Sbjct: 130 VAIKHLICKGYKVCVQPVGTVTYDDESLLKLIKDVNQIKPYAFYLVDTLGVMYRHDMRRF 189 Query: 181 FRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLE 237 F + L E G H+H+NL + AN+ + R +D S GMG G GN E Sbjct: 190 FYLIDNNLSKEICLGFHSHNNLQMSFANAQEMMRLAKQRSIIVDTSCYGMGRGVGNLATE 249 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQ-DRPVRVDRETLALGYAGVYSSFLRHCE 296 +F +K ++ L +++ D + P+ ++ D + ++ + Sbjct: 250 LFADYVNKT-IEYRYALTPILNIVDKYLMPVYAEQRWGYDLPYFLAATVKCHPNYAAYLM 308 Query: 297 TAAARYGLSAVD-ILVELGKRRMVGGQEDMIVDVALDLRN 335 G+ ++ IL + +I + L+ +N Sbjct: 309 KK-DTIGIEKIERILSLIPVEERNEYNSVLIEQLYLNFQN 347 >UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1 Length = 429 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 105/316 (33%), Gaps = 34/316 (10%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG A +++ +AK L A VD ++ Sbjct: 12 KPVEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPA--------- 62 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV----- 118 D+E ++ A+IA D+ A A A V + + + Sbjct: 63 --DMEAMQEMVAAGLRARIAA---TARPLARDIVAAEMANAHEVFMFLPTSALRMEQTLG 117 Query: 119 ---------SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLM-EGYGATCIYVVDS 168 + GM + + PE L + + + + + D+ Sbjct: 118 ITRDQAISLFCSGAEEVCSRGMTLNLVFEDATRSRPEMLTEIVRQVHAQADVRRVILADT 177 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + + R +++E+ + H H++ L VAN++AAV G + ++ G+G Sbjct: 178 VGCAIPAAMEALTRTVRSEIDADIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIG 237 Query: 229 AGAGNAPL-EVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ----DRPVRVDRETLALG 283 AGNA L E + L +HG D + L+ + + Sbjct: 238 ERAGNADLAETVAGLSLLLQREHGVDPHQLVALQEAVEIATGIHQSPTKPVTGINVFRHE 297 Query: 284 YAGVYSSFLRHCETAA 299 L+ + Sbjct: 298 SGIHVDGMLKDPRSYE 313 >UniRef50_B3E4J8 Pyruvate carboxyltransferase n=1 Tax=Geobacter lovleyi SZ RepID=B3E4J8_GEOLS Length = 531 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 135/338 (39%), Gaps = 9/338 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG + L +++ I LD A VD +E+ D + S++ Sbjct: 2 KSIQILDCTLRDGGFVNDWNFGLGSMKSIISRLDKAGVDMVEIGFID--ERRSYDPNRAI 59 Query: 64 HSDLEWIEAAAD--VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 D + +A ++++ I ++ G I + + +RV + D + + Sbjct: 60 QPDTQSFQAVLQGLDIRNSLILGMVDYGTCDIDKIAPKEHSYIDGIRVIFKKKDQDAALR 119 Query: 122 HIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRF 181 ++Q + G + + E + + G + +VD+ G M+ D+ F Sbjct: 120 YLQQIKAKGYKIYVNPVSITGYSDEEICSLIGKINGLDPEGVSIVDTYGLMHRKDLLHYF 179 Query: 182 RALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR---IDASLAGMGAGAGNAPLEV 238 R L G HAH+N L ANSI E +R ID+SL GMG GAGNA E Sbjct: 180 RLFDKYLSNHITLGYHAHNNFQLVYANSIELCELLGERNIIIDSSLYGMGKGAGNANTE- 238 Query: 239 FIAAADKLGWQHGTDLYALMDAAD-DLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 IA ++ L++A D D+++ P + + ++ + Sbjct: 239 LIAMYYNENINSKYEVEHLLEAIDVDILKEYAKAPWGYSLSYYLAASNDCHPDYAKYLLS 298 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 S ++L L + ++I + ++ ++ Sbjct: 299 KKTLAVKSVNELLTSLPVTHKLAFNRELIERLYVEYQD 336 >UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD Length = 314 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 105/294 (35%), Gaps = 36/294 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ I +V RDG+ R ++ + L DA + ++E + Sbjct: 19 PERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEATSFVHPK------WVP 72 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 +D E + A + L + L A AG V V TE+ Sbjct: 73 QLADAEELLARLRRRDGVRYPVL----VPNERGLDRALAAGVTHVAVFASATESFARRNL 128 Query: 117 --------DVSAQHIQYARELGMDTVGFLMMSHMTTPE------NLAKQAKLMEGYGATC 162 + I ARE G+D G++ M E + + + G T Sbjct: 129 NSGLDAQFAMFEPVIARAREAGLDVRGYVSMCFGDPWEGIVPTEQVVTVGRRLLDAGCTQ 188 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D+ G + + A +H H +AN++AA+ +G +DA Sbjct: 189 LSLGDTIGVATAAAVERLLDAFIEGGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDA 248 Query: 223 SLAGMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 S G+G GN E + D LG +HG DL AL++ + + R L Sbjct: 249 SAGGLGGCPYAESATGNLATEDLVWLLDGLGVEHGVDLDALVETSRWMSRQLGR 302 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 186 bits (473), Expect = 9e-46, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 110/317 (34%), Gaps = 37/317 (11%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K I D TLR+G +++ E+ +I L+ +++ IEV H Sbjct: 2 KPFQILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHPGIS----------- 50 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE-------- 115 D E A + A+I T+ ++ A +A A V + + Sbjct: 51 ALDEEICRKVAQSARRAQILMH---ARATVEEVHAAKRAKADWVGIWASINDVSIQTKFR 107 Query: 116 -------ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + Q + A++LG+ + + T E ++ GA I + D+ Sbjct: 108 HHEESYILEKVQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADT 167 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G + E + +H H++ L AN++AA++ G IDA++ G+G Sbjct: 168 VGIWEPDTCKKIVTRAIEEFG--CEIEVHLHNDFGLAQANALAAIDAGASVIDATILGIG 225 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL-----VRPLQDRPVRVDRETLALG 283 AG L A KL H L + + + RP + + Sbjct: 226 ERAGITDLIQLTVALQKLRNDHRYSLDRIPELVQAIRLTTGYRP-DELRPITGQNAFTHT 284 Query: 284 YAGVYSSFLRHCETAAA 300 A + R+ + Sbjct: 285 SAYHVQAVKRNSKAYEP 301 >UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellular organisms RepID=HMGCL_CHICK Length = 298 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 100/297 (33%), Gaps = 37/297 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ + +V RDG+ + ++ L + + IE + Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPR------WVP 56 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------- 115 +D + + + L + + A AGA+ V + +E Sbjct: 57 QMADHAEVMQGINKLPGVSYPVL----TPNLKGFQAAVAAGAKEVSIFGAASELFTKKNI 112 Query: 116 -------ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 + ++ + AR + G+ + +A+ +K M G Sbjct: 113 NCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYE 172 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D G +++ A+ E+ +H H +AN + A++ G +DA Sbjct: 173 ISLGDRIGIGTPGSMKEMLAAVMKEVPVGA-LAVHCHDTYGQALANILVALQMGVSVVDA 231 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPV 273 S+AG+G GN E + + LG G DL LMD + L R Sbjct: 232 SVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTN 288 >UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Bacteria RepID=HMGCL_BACSU Length = 299 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 98/295 (33%), Gaps = 37/295 (12%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGF 61 KK+ I +V RDG+ + E+ L + IE+ + Sbjct: 3 YPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPK------WI 56 Query: 62 GAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------ 115 A D + D K A L + L+NA + G V +E Sbjct: 57 PALRDAIDVAKGIDREKGVTYAAL----VPNQRGLENALEGGINEACVFMSASETHNRKN 112 Query: 116 --------ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGAT 161 + Q A++ + T + E + + ++ + +G + Sbjct: 113 INKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGIS 172 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + + D+ GA N + + AL A Q +H H +AN + A++ G D Sbjct: 173 ELSLGDTIGAANPAQVETVLEALLARFPAN-QIALHFHDTRGTALANMVTALQMGITVFD 231 Query: 222 ASLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 S G+G GNA E + +++ + L L+ AA + + Sbjct: 232 GSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSAAKWIEEKMGK 286 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 68/349 (19%), Positives = 118/349 (33%), Gaps = 22/349 (6%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQGSSFNY---- 59 +L I DVTLRDG +S IAK L VD +E+A +G Sbjct: 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKII 66 Query: 60 -GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 E IE V + + + G ++ L T Sbjct: 67 EWAETEQLTERIEILGFVDGNKTVDWIKDSGARVLNLLTKGSLHHLEKQLNKTPKEFFAD 126 Query: 119 SAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMS 175 + I+YA + G+ +L +P+ + K + I++ D+ G ++ Sbjct: 127 VSIVIEYAIKNGLKINVYLEDWSNGFRNSPDYVEALVKHLSKERIERIFLPDTLGVLSPE 186 Query: 176 DIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 + +L + P H H++ L VANS+ A+ G + AS+ G+G AGN P Sbjct: 187 ETFQGVDSLVQK-YPNLHFEFHGHNDYDLSVANSLQAIRAGVKGLHASMNGLGERAGNTP 245 Query: 236 LEVFIAAAD-KLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGVYS- 289 LE + K + + A+ +A+ + + + V + Sbjct: 246 LEALVTTIHDKSQAKTNINELAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 Query: 290 ---SFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 L R+G LGK + + + + L + Sbjct: 306 DKKGNLYANPILPERFG---RKRSYALGKLSGKASISENVKQLGMVLSD 351 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 129/338 (38%), Gaps = 27/338 (7%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 ++D TLR+GM A ++L+ +IA+++ + + V++ + Sbjct: 2 LTDDTLREGMQAPGIAFTLDEKIRIAQSISKSGIKRALVSYPSAHESE------------ 49 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARV-VRVATHCTEADVSAQHIQYA 126 +EAA + G D+ + G++V + + + + ++YA Sbjct: 50 --VEAARKITDLHLFDDTYSLGRSIKEDVDSIISTGSKVTLHLPFGDYDINKICDVVKYA 107 Query: 127 RELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKA 186 + ++ E + AK + GA+ + + D+ G + D +K Sbjct: 108 SDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVSYIKQ 167 Query: 187 ELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKL 246 LK + +H H++ L +ANSIA +E GCD +D ++ G+G G A + +K Sbjct: 168 NLK--VKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIADTASIASYLEKA 225 Query: 247 GWQHGTDLYALMDAADDLV---------RPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 G++ + L D + R D R L++ +S + Sbjct: 226 GYEDKINFEMLRKTYDLMSELILRKAGYRFFADNMPIFGRNVLSITAGTHSTSKVFPNSR 285 Query: 298 AAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 + + ++ + ++ + E + + +++ Sbjct: 286 VSLNVYAGSR-LVASILRKNGIEPDERKVKLLVSKIKD 322 >UniRef50_B2UP73 Methylmalonyl-CoA carboxytransferase n=4 Tax=Verrucomicrobia RepID=B2UP73_AKKM8 Length = 507 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 60/340 (17%), Positives = 118/340 (34%), Gaps = 26/340 (7%) Query: 1 MNGKKLYISDVTLRDGMHAIR-HQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN + + LRDG ++ + ++ IA LD ++E G + Sbjct: 1 MNP--VTFNCTVLRDGHQSLAATRMKTADMLPIAPILDSMGFSALETWGGATIDAGLRFL 58 Query: 60 GFGAHSDLEWIEAAADVVKHAKI-------ATLLLPGIGTIHDLKNAWQAGARVVRVATH 112 L+ ++ AA H + + + + G + R+ Sbjct: 59 KEWPFDRLDALKKAAPKTPHMMLLRGQNIVGYTNYADDVVEAFVAMSAKHGMNIFRIFDC 118 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + I+ A++ G G + S + T + + + GA I + D G Sbjct: 119 VNDPRNMETSIRAAKKAGAQAHGTICYTTSPVHTTQTFVDMGRELADMGADAIVIKDMAG 178 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + ++ ALK +L +H H LG + ++A++ G D D S++ G Sbjct: 179 LIPPYVTQELVSALKKDL--NIPVWIHTHDTAGLGASTYLSAIDAGVDACDVSISPFANG 236 Query: 231 AGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD--------RPVRVDRETLAL 282 G +A + + D L++ ++ L +P+ + R VD +TL Sbjct: 237 TGQPDCLRMLALLNGNPRKPDYDADKLIEVSEML-KPVYEGLGKFASHRNEVVDSDTLRY 295 Query: 283 GY-AGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGG 321 G+ S+F + ++ E+ R G Sbjct: 296 QVPGGMLSNFRTQLKEQGMEDKFE--EVFAEIPVVRKALG 333 >UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5 Length = 328 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 62/324 (19%), Positives = 110/324 (33%), Gaps = 48/324 (14%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 ++ I +V+ RDG+ +E R++ AL A + IE+ + Sbjct: 27 EVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITSFVSPK------WVPQL 80 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA---- 120 +D E + + + L L+ A G R + V +EA A Sbjct: 81 ADAEELARTLPAERGVTFSALC----PNARGLERALAVGLREIAVFLSASEAHNRANINK 136 Query: 121 ----------QHIQYARELGMDT------VGFLMMSHMTTPENLAKQAKLMEGYGATCIY 164 + + ARE G+ V P + + A+ + G + Sbjct: 137 SIDDTLSVFSEIVPPAREAGLAVRAYVSTVWGCPYEGDVDPARVVRIAERLIDLGCYQVS 196 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ G D R + PE + +H H +AN + +E G DAS+ Sbjct: 197 LGDTIGVGTPRQTHDIVRRFLDAMPPE-RFALHLHDTRGTALANILVGLELGVRDFDASV 255 Query: 225 AGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRE 278 AG+G AGN E + +G + G DL +++A + + + RP+ Sbjct: 256 AGVGGCPYAPGAAGNMATEDLVFMLHGMGVRTGVDLDKVIEAGN-VAEQVIGRPLP---- 310 Query: 279 TLALGYAGVYSSFLRHCETAAARY 302 V+ + R Sbjct: 311 ------GKVHRAGPFRLRRQPTRD 328 >UniRef50_C5T2M7 Pyruvate carboxyltransferase n=1 Tax=Acidovorax delafieldii 2AN RepID=C5T2M7_ACIDE Length = 358 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 99/310 (31%), Gaps = 37/310 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 ++ + DV RDG+ + E + L DA + +IEV + Sbjct: 60 PSRVKLIDVGPRDGLQNEKSPVPAEVKIGLVHRLQDAGLKNIEVTSYVSPK------WVP 113 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE------- 115 +D + + + L + + A + V +E Sbjct: 114 QMADNHEVMSGIARQSGVVYSVL----TPNLKGFEAAVLDRPDEIVVFGSASEAFSQKNI 169 Query: 116 -------ADVSAQHIQYARELGMDTV------GFLMMSHMTTPENLAKQAKLMEGYGATC 162 + A ++ AR G+ PE +A A LM+ G Sbjct: 170 NCSIAESIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEIAPERVAYLAGLMKQIGVQH 229 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I V D+ G ++ A H H +AN++A +E G + D Sbjct: 230 IGVADTIGVGTPRKVQRAVEATLQHYDLN-DISGHFHDTYGQALANTLATLEMGVWQYDT 288 Query: 223 SLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD 276 S+AG+G GN E + +G + G DL L+DA + L +P Sbjct: 289 SVAGLGGCPYAKGATGNVATEDVVYMLHGMGIETGIDLDKLIDAGAYISGFLGRKPNSRA 348 Query: 277 RETLALGYAG 286 L AG Sbjct: 349 ATALLNKRAG 358 >UniRef50_Q07TZ1 Pyruvate carboxylase n=41 Tax=Bacteria RepID=Q07TZ1_RHOP5 Length = 1149 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 59/368 (16%), Positives = 120/368 (32%), Gaps = 40/368 (10%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVD---SIEVAHGDGLQGSSFNY 59 K++ ++D T+RDG ++ + ++ ++A++ + S+E G + Sbjct: 532 KRVLVTDTTMRDGHQSLLATRMRSHDLVEVAESY-ATGLPQLFSLECWGGATFDVAM--- 587 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRV 109 F E + + V + + LL P ++ A + G V R+ Sbjct: 588 RFLTEDPWERLSQIRERVPNILLQMLLRGANGVGYTNYPDNVVRFFVREAAKGGVDVFRI 647 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGAT 161 + I + + + + AK ME GA Sbjct: 648 FDALNWMENIHPAIDAVASENKIAEAAVCYTGDILDPDRAKYSLKYYVDLAKEMERAGAH 707 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + V D G + + F+AL+ E+ + H H + A+ +AAVE G D +D Sbjct: 708 ILGVKDMAGLLKPQAAKVLFKALREEI--QIPIHFHTHDTSGIAAASVLAAVEAGVDAVD 765 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAA---DDLVRPLQDRPVRVDRE 278 A++ + L +AA G D + + + + + + Sbjct: 766 AAMDALSGLTSQPCLGSIVAALKGTERDPGLDPAVIRKLSFYWEAVRTQYRAFESDLRSG 825 Query: 279 TLALGYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMIVDV 329 + + + + A GL D+ G V ++ D+ Sbjct: 826 ASEVYLHEMPGGQFTNLKEQARGLGLETKWHEVAQTYADVNRLFGDIVKVTPTSKVVGDM 885 Query: 330 ALDLRNNK 337 AL + + Sbjct: 886 ALSMVAAE 893 >UniRef50_B7ANX1 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B7ANX1_9BACE Length = 538 Score = 185 bits (469), Expect = 3e-45, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 129/346 (37%), Gaps = 15/346 (4%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 K + I D TLRDG I ++S + +R I++ L D+ +D +EV + F Sbjct: 2 KNISILDCTLRDGGRVINCEFSDDEIRDISRRLSDSNIDIVEVGFLRDSKKVHFEGNSTF 61 Query: 64 HSDLEWIEA-AADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV----ATHCTEADV 118 +D+ I + + G+ L +RV + + D Sbjct: 62 FTDVNQIAPYLDKSSGNCMYVAFIDYGMFDFDTLGQCDGTSVDGIRVGFTKKDYYSSRDD 121 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIR 178 + + + G + S + + + L+ +VD+ GAM D++ Sbjct: 122 IIRCLNIVKARGYKLFVQGVNSLSYSDKEMLDLVDLVNEVHPYSFGIVDTYGAMYEDDLQ 181 Query: 179 DRFRALKAELKPETQTGMHAHHNLSL--GVANSIAAVEEGCDR--IDASLAGMGAGAGNA 234 + + + + H+H+N L +A SI + + IDA+L GMG AGN Sbjct: 182 RIYALINNNMHKDICIDFHSHNNYQLSFSLAQSIIRLSDSVRHIIIDATLNGMGKVAGNL 241 Query: 235 PLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRH 294 E+ + + D ++D DD + P +++ ++ G+Y S + Sbjct: 242 NTELIVDYMVR-KLNCNYDFEQILDIIDDYIYPYKEKDFW--GYSIPALIGGMYQSHPNN 298 Query: 295 CETAAARYGLSAVDI---LVELGKRRMVGGQEDMIVDVALDLRNNK 337 ++ L DI L + + D I + L+ NK Sbjct: 299 VLYLTNKFRLQTKDIKNLLSMIEPAKRTRYDYDNIERIYLEYSGNK 344 >UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT Length = 577 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 56/382 (14%), Positives = 104/382 (27%), Gaps = 62/382 (16%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ D TLRDG S E+ +IA LD + IE + Sbjct: 6 SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQFFWQL 65 Query: 63 AHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHC 113 L+ + A + +L G + +W T Sbjct: 66 QEDPLKLSQIVAFCSTRRPHTHAADEPMLQDILAAGSSWVTIFGKSWDLHVTTGLKTTLE 125 Query: 114 TEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGG 170 + I++ R G + + + + K GA + + D+ G Sbjct: 126 ENLAMIRDTIEFFRSQGRRVIYDAEHWFDGYKHNRDYALQTLKAAMAAGAEWLVLCDTNG 185 Query: 171 AMNMSDIRDRFRALKA--------------------------------------ELKPET 192 ++ + + L Sbjct: 186 GTLPHEVSQIVQDVVKVTRDWGRINSKLDQSGQVVSEEVEKSTNSLPNTQYPIPNLPFPI 245 Query: 193 Q-TGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHG 251 G+H H++ + VAN++AAV G + ++ G G GNA L I Sbjct: 246 PQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLKLGYSC 305 Query: 252 T---DLYALMDAADDLVRPL---QDRPVRVDRETLALGYAGVYSSF-----LRHCETAAA 300 L L +A+ + + D + G++ S L + Sbjct: 306 ITEHQLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTYEHIQPE 365 Query: 301 RYGLSAVDILVELGKRRMVGGQ 322 + G ++ E V + Sbjct: 366 QVGNRRRIVISEQSGISNVLAK 387 >UniRef50_A1VTK3 Pyruvate carboxyltransferase n=109 Tax=cellular organisms RepID=A1VTK3_POLNA Length = 744 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 73/347 (21%), Positives = 121/347 (34%), Gaps = 40/347 (11%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M ++ IS+V RDG+ +++ + + AL A V IEVA Sbjct: 31 MYSPEILISEVGPRDGLQSVKACMPTADKLRWIDALYAAGVREIEVASFVP------ARL 84 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS- 119 +D + A + ++ L + + A AG + V + A Sbjct: 85 LPQMADAAEVVRHAITLPGLRVMAL----VPNRRGAEAALAAGVHKLTVPVSASAAHSLA 140 Query: 120 ------AQHIQYAR---------------ELGMDTVGFLMMSHMTTPENLAKQAKLMEGY 158 + ++ R E G+ T + + +++ + A Sbjct: 141 NVRRTREEMVEEVRAIAALRRDLAPHVGLEAGISTAFGCTLQGLVAEDDVIRLAAQCIAA 200 Query: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218 GA + D+ G N + +R FR L+AE+ H H+ LG+AN +AA EEG Sbjct: 201 GADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAG-AAHMHNTRGLGLANCLAAYEEGVR 259 Query: 219 RIDASLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP 272 DASL G+G GN E + + +G + G DL L+ A L L P Sbjct: 260 TFDASLGGLGGCPYAPGASGNVVTEDLVFMFEAMGLRTGIDLEKLIAARAPLKAGLPGEP 319 Query: 273 VRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMV 319 + L V + A + + R+V Sbjct: 320 LYGLTPEAGLPKGFVQ-GARMAAPASPAVEESDTRETPLPYAGIRVV 365 >UniRef50_D2R6U4 Pyruvate carboxylase n=6 Tax=cellular organisms RepID=D2R6U4_9PLAN Length = 1146 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 57/370 (15%), Positives = 108/370 (29%), Gaps = 40/370 (10%) Query: 1 MNGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDAR--VDSIEVAHGDGLQGSSF 57 + K L ++D T RD ++ ++ +++ +A+A + S+E+ G S Sbjct: 529 LKQKALLLTDTTFRDAHQSLLATRFRTKDLLNVAEAYAHLASDLFSLEMWGGATFDTSM- 587 Query: 58 NYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGT----------IHDLKNAWQAGARVV 107 F + + + V + L A AG + Sbjct: 588 --RFLKECPWQRLADMREKVPNICFQMLFRASNAVGYSSYPDNIVREFCSEATAAGMDIF 645 Query: 108 RVATHCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYG 159 R+ ++ ++ G + + + + AK +E G Sbjct: 646 RIFDALNFLPNMRVAMEAVQKAGGVCEPAICYTGDILNPARSKYDLKYYVELAKELEKSG 705 Query: 160 ATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDR 219 A + + D G + LK E+ H H + A+ + A E D Sbjct: 706 AHILAIKDMAGLCKPYAAELLVKTLKQEIG--IPIHFHTHDTAGMQAASILKAAEVKLDI 763 Query: 220 IDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDR-- 277 D ++A M G L I +D + +++ D Sbjct: 764 ADGAMASMSGGTSQPNLNAIIEGLRFGKRDTNLSAEHFSQISD-YWQSVREFYTPFDGVM 822 Query: 278 --ETLALGYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMI 326 T L + + A GLS ++ LG V + Sbjct: 823 LPATAELYSHEMPGGQYTNLYQQARALGLSERWPEICKMYAEVNQLLGDIVKVTPTSKAV 882 Query: 327 VDVALDLRNN 336 D+AL + N Sbjct: 883 GDLALFMVAN 892 >UniRef50_B2V325 Pyruvate carboxylase n=9 Tax=Clostridiales RepID=B2V325_CLOBA Length = 1146 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 66/368 (17%), Positives = 123/368 (33%), Gaps = 38/368 (10%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDAR--VDSIEVAHGDGLQGSSFN 58 N KL ++D T+RD ++ + ++++ IAKA + S+E+ G + Sbjct: 525 NQNKLLLTDTTMRDAQQSLMATRVRSKDMKNIAKATALYGNDLFSLEMWGGATFDTAYRF 584 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVR 108 L+ + + + L+ P +K + +G + R Sbjct: 585 LKESPWRRLDSLR---KRIPNVMFQMLIRGANGVGYKNYPDNVIREFIKESANSGIDIFR 641 Query: 109 VATHCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGA 160 + ++ + L + + + +AK +E GA Sbjct: 642 IFDSLNWLKGIEVSLEEVLKANKVAEVALCYTGDILDENRDKYSLKYYVDKAKEIEKMGA 701 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + + D + + ALK E+ +H H GVA + A + G D I Sbjct: 702 HILAIKDMSALLKPYAAKKLITALKNEVS--IPIHLHTHDTTGNGVATVLMAADAGVDII 759 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDL--VRPLQDRPVRVDRE 278 D + M L +AA + G D+ + +D VRP+ D+ R Sbjct: 760 DTTFNSMSGLTSQPALNSIVAALNNTDRDTGIDIRGIQKLSDYWDAVRPVYDQFESDLRS 819 Query: 279 TLALGY-----AGVYSSFLRHCETAAARYGLS-----AVDILVELGKRRMVGGQEDMIVD 328 A Y G YS+ E+ + + + LG V M+ D Sbjct: 820 GSAEIYKFEIPGGQYSNLKPQVESFGLGHRFNEVKKMYKKVNDLLGDIIKVTPSSKMVGD 879 Query: 329 VALDLRNN 336 +A+ + N Sbjct: 880 MAIFMVQN 887 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 63/343 (18%), Positives = 119/343 (34%), Gaps = 25/343 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I D TLRDG +SL++ I + LD+ VD +E + + + + Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDAEYFRRVQ 61 Query: 64 HSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 +L+ + A + + L+ G + + V T Sbjct: 62 DLNLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFHVTDVLRVTLEE 121 Query: 115 EADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A + Y G + + PE A+ + GA + + D+ G Sbjct: 122 NLAMIADSVAYIVGAGREVIYDAEHFFDGWKANPEYAAETIRAAAKAGARMVVMCDTNGG 181 Query: 172 MNMSDIRDRFRALKAELKP-ETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 +I + A L G+H H++ L VANS+AAV+ G ++ ++ G G Sbjct: 182 SLPEEIAEYAAKAIAALTEFNVPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTINGFGER 241 Query: 231 AGNAPLEVFIAA--ADKLGWQH--GTDLYALMDAADDLVRPL---QDRPVRVDRETLALG 283 GNA L IA + G++ G L + + + + ++ Sbjct: 242 CGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQSAFAH 301 Query: 284 YAGVYSSFL-----RHCETAAARYGLSAVDILVELGKRRMVGG 321 G++ + + G ++ EL R + Sbjct: 302 KGGMHVHAINRAASSYEHIDPQSVGNERRVLVSELSGRSNIVA 344 >UniRef50_C1D9E0 Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular organisms RepID=C1D9E0_LARHH Length = 306 Score = 184 bits (466), Expect = 5e-45, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 99/298 (33%), Gaps = 37/298 (12%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M+ + + +V RDG+ + ++ + L A + IE + Sbjct: 1 MSKHHVTLVEVGPRDGLQNESRSLPVGLRVELVERLVAAGLSVIEAGSFVSPK------W 54 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE----- 115 + + A ++ L + L+ A AG R + V T +E Sbjct: 55 VPQMAGTAEVLAGIAPAPGLRLPVL----VPNRQGLQAAMDAGVREIAVFTAASETFAFK 110 Query: 116 ---------ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGA 160 A I AR G+ G+ PE + + + G Sbjct: 111 NLNCSIGDSLVRFAPVIDEARLAGLRVRGYVSCVLGCPYEGSVAPERVVDVSASLLKLGC 170 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 I + D+ GA R R L E+ E + H H + AN AA EG Sbjct: 171 DEISLGDTIGAGTPDTTRRLIRELAREVPVE-RLAGHFHDTWGMAAANVYAAWLEGMRTF 229 Query: 221 DASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRP 272 D S+ G+G GN E + D +G G L A+++ A + R L +P Sbjct: 230 DCSVGGLGGCPYAPGATGNVATEDLVHLFDGMGITTGVSLAAVVETAHWISRQLGRQP 287 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 184 bits (466), Expect = 5e-45, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 113/310 (36%), Gaps = 35/310 (11%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG + + +A+ + + + IE Sbjct: 30 IKIHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVS------------- 76 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 E A +++VK + + D+K A G + + E Sbjct: 77 -AEDARAVSEIVKRRLPTEIFGFARCMVDDVKRAADCGVSGIVIEIPSNEEMIREAYGWS 135 Query: 116 ----ADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYG-ATCIYVVDSGG 170 ++S + + A+ G+ TV F + + + K + G + VVD+ G Sbjct: 136 LEKAVELSVKATKAAQGAGLYTVFFPIDMTRANIDWVLKLIGQVAADGHMDALAVVDTMG 195 Query: 171 AMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 + + A+K+ + + +H H + LGVANSI + G D + +++ G Sbjct: 196 GLAPHTVPYLIDAIKSRI--DKPLEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGER 253 Query: 231 AGNAPLEVFI-AAADKLGWQHGTDLYALMDAADDLVRPL---QDRPVRVDRETLALGYAG 286 AGNA E A G+ G D + + L + + V + + +G Sbjct: 254 AGNAAYEHLALALLTMYGYDLGLDYSKIYSLSKLLRSFIDLPVRGNMGVIGDRVFDIESG 313 Query: 287 VYSSFLRHCE 296 + + + ++ + Sbjct: 314 IVAGWYKNVK 323 >UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ Length = 435 Score = 183 bits (465), Expect = 7e-45, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 107/327 (32%), Gaps = 14/327 (4%) Query: 7 YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSD 66 + DVTLRDG A+R + L+ I K L V IEV + Sbjct: 42 FFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCSRLSSIA 101 Query: 67 LEWI-----EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ 121 + + A + + IH + + V + + ++ Sbjct: 102 PDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKVLEKISE 161 Query: 122 HIQYAREL-GMDTVGFLMMSHMTT----PENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + +A+ L G H + + + YGA I + ++ Sbjct: 162 SVSFAKSLVGSKGEIQFSGEHFGDSLENLDFAVEAFRTALNYGADIINLPNTVERYRPWL 221 Query: 177 IRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPL 236 +A++ L + +H H++L + A ++ + G +++ +L G+G AGN Sbjct: 222 FVSMVKAVRNVLPENAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLGERAGNTNT 281 Query: 237 EVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAGVYSSFL 292 A G +L A+ + + + P+ ++ V + ++ Sbjct: 282 YEVAIALHNCGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVISHRSGIYQDGVA 341 Query: 293 RHCETAAARYGLSAVDILVELGKRRMV 319 + + Y ++ + R+ Sbjct: 342 KTRHLSKGAYRAFNATLIGRPEEDRIE 368 >UniRef50_Q4ZRW6 HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=Q4ZRW6_PSEU2 Length = 342 Score = 183 bits (465), Expect = 7e-45, Method: Composition-based stats. Identities = 88/326 (26%), Positives = 143/326 (43%), Gaps = 9/326 (2%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DVTLRDG + ++ + + I L +A VD E+ + G +G + Sbjct: 4 VKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDV 63 Query: 66 DLEWIEAAADVVKH-AKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQ 124 +IE A K ++A ++ P T DL + G ++RV + D + Sbjct: 64 GAVFIEKIAQAAKGRIELAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLS 123 Query: 125 YARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRAL 184 AR+ G + TP ++ A EG GA + DS G M +D+ F L Sbjct: 124 LARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLFSRL 183 Query: 185 KAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAAD 244 + L G HAH+NLSL +AN+ AA+E G + ID S+ GMG GAGN L + +A + Sbjct: 184 SSRLL--VPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYLE 241 Query: 245 KLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGL 304 + G HG DL +++ ++ R + + + LG + R+ L Sbjct: 242 RTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQL 301 Query: 305 SAVDILVELGKRRMVGGQEDMIVDVA 330 ++ +E V Q+D + +A Sbjct: 302 TSEYRAIE------VMYQQDKVARLA 321 >UniRef50_UPI0001B44BFA 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Mycobacterium tuberculosis KZN 4207 RepID=UPI0001B44BFA Length = 483 Score = 183 bits (465), Expect = 8e-45, Method: Composition-based stats. Identities = 81/276 (29%), Positives = 138/276 (50%), Gaps = 7/276 (2%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 ++ + D T+RDG +A+ QY+ ++VR+I LD A + IE+ HG + G++ G A Sbjct: 8 REPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTI-GAAAAQGPAA 66 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHI 123 H+D E+ AA VV++A++ +++P + I + A +R+ TE ++ + Sbjct: 67 HTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDY-LDFLRICVIATEFELVMPFV 125 Query: 124 QYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRA 183 + A+ G++ L+ SH+ P+ LA K G +YVVD+ G D R A Sbjct: 126 ERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA 185 Query: 184 LKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAA 243 L+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E +AA Sbjct: 186 LRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAAL 243 Query: 244 DKLGWQHGT-DLYAL--MDAADDLVRPLQDRPVRVD 276 + D + + +LV P +R Sbjct: 244 QRRDLAGDYLDFLRICVIATEFELVMPFVERAQSKG 279 Score = 160 bits (404), Expect = 9e-38, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 132/318 (41%), Gaps = 24/318 (7%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 + +Y+ D T + E+ R+ +AL + V N Sbjct: 163 RIVYVVDTT---------GTFLPEDARRYVEALR--GASDVSVGF-----HGHNNLAMAV 206 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ------AGARVVRVATHCTEAD 117 + LE +A AD + + G I L A Q +R+ TE + Sbjct: 207 ANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRDLAGDYLDFLRICVIATEFE 266 Query: 118 VSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + ++ A+ G++ L+ SH+ P+ LA K G +YVVD+ G D Sbjct: 267 LVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDA 326 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 R AL+ + G H H+NL++ VAN++ A + G D +D +L G G GAGN +E Sbjct: 327 RRYVEALRGA--SDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIE 384 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 +AA + G DL + DAA + + +D ++ G+ G+ S + H Sbjct: 385 CLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRA 444 Query: 298 AAARYGLSAVDILVELGK 315 AA + GLS ++ + K Sbjct: 445 AAQQAGLSVSHVIRQTAK 462 >UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteria RepID=Q15RQ1_PSEA6 Length = 305 Score = 183 bits (464), Expect = 9e-45, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 101/305 (33%), Gaps = 37/305 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K+ I +V RDG+ + L + +AL + + IE + Sbjct: 6 PSKVKIVEVGPRDGLQNEKASIDLVTKVTLIEALAKSGLSMIETGSFVSPK------WVP 59 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------ 116 +D + AA + + + + + A +AGA V + +E+ Sbjct: 60 QMADSAQVFAAINR----QDTVIYSALTPNLTGFEAALEAGADEVAIFGSASESFSQKNI 115 Query: 117 --------DVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 I A+ + G+ P N+A AK + G Sbjct: 116 NCSIAESLARFEPVIAAAKAKNIKVRGYVSCVLGCPYEGEIAPANVASVAKTLFEMGCYE 175 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D+ G + A+ + P +H H +AN + A++ G + +D+ Sbjct: 176 ISLGDTIGVGTPIATQIMLNAVLD-VVPLCAVAVHFHDTYGQALANILVALQLGINVVDS 234 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVD 276 ++AG+G GN E + +G G DL L A D+ L V Sbjct: 235 AVAGLGGCPYAKGASGNVATEDVVYMLHGMGIATGIDLSMLAKAGQDVCTKLGINSVSKV 294 Query: 277 RETLA 281 A Sbjct: 295 ANVYA 299 >UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MEN7_ALKOO Length = 306 Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 102/287 (35%), Gaps = 33/287 (11%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + I +V RDG ++ + E+ I + L DA IE+ + Sbjct: 4 PKSVEILEVCPRDGFQNVKDFIATEDKIAIVERLIDANFKRIELGSFVSPKA------IP 57 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH 122 +D + + AAA + + +++A AG + +E+ A Sbjct: 58 QMADTKEVVAAAKQYA-VDQDIKFVALVPNARGVESAIAAGVDQITYVISASESHNKANV 116 Query: 123 IQYARE-------------------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCI 163 + E LG+ T E + + K G I Sbjct: 117 NRTVAESMEQYEALIKEYKGDIDFRLGLATTFGCPFGDEVKIERIQEMCKWAFDLGTVEI 176 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N + + R L E PE + MH H L +AN++AA++ G + +++ Sbjct: 177 LMADTVGLGNPKKVSEVMRTLVNEFGPE-KFVMHLHDTRGLALANTLAAMQYGITKFESA 235 Query: 224 LAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDL 264 G+G GNA E ++G + ++ + +A + Sbjct: 236 TGGLGGCPFAPGASGNAATEDLYYMLSEMGIETNIEIEKVYEAIQLI 282 >UniRef50_B8LCZ8 Predicted protein n=3 Tax=Eukaryota RepID=B8LCZ8_THAPS Length = 1291 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 62/371 (16%), Positives = 119/371 (32%), Gaps = 42/371 (11%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDA--R---VDSIEVAHGDGLQGSSF 57 + + ++D T RD ++ + ++ + A+A + A V S+E+ G S Sbjct: 638 QNVLVTDTTWRDAHQSLLATRMRTADLLKAAEATNTAFNGTSDVFSLEMWGGATFDVSMN 697 Query: 58 NYGFGAHSDLEWIEAAAD------VVKHAKIATLLL-PGIGTIHDLKNAWQAGARVVRVA 110 LE + AA +++ A + P K A+++G + RV Sbjct: 698 FLRECPWKRLEELREAAPDMLFQMLLRGANAVGYTVYPDNVVYEFCKQAYKSGNDIFRVF 757 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSH---------MTTPENLAKQAKLMEGYGAT 161 D I+ A G + + + A + GA Sbjct: 758 DSLNYVDNMELGIKAAAASGGFVEAAICYTGDVTSSDPSNKYNLKYYLDFATQLVDLGAH 817 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 + + D G + L++ P+ +H H +GVA A E G D +D Sbjct: 818 ALAIKDMAGLLTPRAATLLVSELRSAF-PDVPIHLHTHDTAGMGVAAMFAGAEAGADIVD 876 Query: 222 ASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLA 281 ++ M + L ++A G + DL AL ++ ++ + + + L Sbjct: 877 GAIDAMSGLSSQPCLGALVSAL---GDKSNVDLDAL-QVLNEYWESVRHQYNPFEVQALN 932 Query: 282 L------GYAGVYSSFLRHCETAAARYGLSAV---------DILVELGKRRMVGGQEDMI 326 + + + + GLS LG V + Sbjct: 933 AAIGSNVYKHEIPGGQYTNLLFQSKQLGLSGRFAEVKKAYALANKLLGDIPKVTPSSKTV 992 Query: 327 VDVALDLRNNK 337 D+A + K Sbjct: 993 GDLAQFIVGLK 1003 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 65/351 (18%), Positives = 114/351 (32%), Gaps = 26/351 (7%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 M+ K +++ D TLRDG + S + +IA+ LD +D IE + + Sbjct: 1 MSTK-IFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFN 59 Query: 61 FGAHSDLEWIEAAA---------DVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVAT 111 L + AA + L+ G + V + Sbjct: 60 AMRGVGLRNAKLAAFGSTHHPSHTPETDPTLTALISSGARVAAVFGKSCPRHVEVALGIS 119 Query: 112 HCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVVDS 168 ++ I + ++ + E + +GA C+ + D+ Sbjct: 120 RERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALAVLRTAWEHGADCLVLCDT 179 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G +I R ++ L P G+HAH++ L VANS+AAV G ++ ++ G+G Sbjct: 180 NGGTMPEEISSIIRTVRERL-PHALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGIG 238 Query: 229 AGAGNAPLEVFIAAAD----KLGWQHGTDLYALMDAADDLVR---PLQDRPVRVDRETLA 281 GNA L I G L L A + R Sbjct: 239 ERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAAF 298 Query: 282 LGYAGVYSSFLR-----HCETAAARYGLSAVDILVELGKRRMVGGQEDMIV 327 GV+ S + + + G + ++ E G R + + Sbjct: 299 AHKGGVHVSAIMKEAALYEHIDPSLVGNAQRVLMTEQGGRSNILSLSRTLG 349 >UniRef50_C9RJA2 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJA2_FIBSS Length = 313 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 127/306 (41%), Gaps = 14/306 (4%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNY 59 M + + + D T+RDG +H +SLE VR++ L A VD +E+ + + + Y Sbjct: 1 MYYETIKVLDCTIRDGGLVNKHDFSLEFVRRLYTLLTAAGVDYMEMGYKNSPELFDPKEY 60 Query: 60 GFGAHSDLEWIEAAAD-VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 G D + + D + K+A + G + +K A ++ ++ RVA++ D Sbjct: 61 GPWKFCDDDLLWKVKDGIDSKMKMAVMADVGRVNMDAVKPASESPYQMFRVASYVKNIDK 120 Query: 119 SAQHIQYARELGMDTVGFLMMSHMTT-PENLAKQAKLMEGYGATCIYVVDSGGAMNMSDI 177 + ++G +T +M PE ++ E A +Y+VDS GA DI Sbjct: 121 GISMVNAFHDMGYETTLNIMAVSRDRGPELDEALHQVNEECKADVLYLVDSFGAFYQEDI 180 Query: 178 RDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLE 237 K + + G H H+N L +N+I A+ D +D S++GMG GAGN E Sbjct: 181 DKELARYKG-IVKNKKFGFHGHNNQQLAFSNTIQAIINHVDYLDGSVSGMGRGAGNCTTE 239 Query: 238 VFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCET 297 + + DL ++DA +L PLQ + + + L Sbjct: 240 LLLGFLK----NPKYDLRPVLDAIQELFLPLQSKYEW------GYIIPQMITGMLNRHPQ 289 Query: 298 AAARYG 303 A Sbjct: 290 DAIAVR 295 >UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. G11MC16 RepID=B4BIN3_9BACI Length = 300 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 99/284 (34%), Gaps = 37/284 (13%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I DV+ RDG+ + S E R + + L + + IE + Sbjct: 4 VQIIDVSPRDGLQNEQVIVSSEKKRMLIEMLVKSNIRKIEATSFVHP------LKVPQMA 57 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE---------- 115 D E + + + ++ L+ + + A Q + T TE Sbjct: 58 DAEQVLKLCEELSEIELVALI----PNLKGFQRAKQTKISEINWVTAATETFNYKNIGMS 113 Query: 116 ----ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATCIYV 165 Q +Q +R L + +P + + GA I + Sbjct: 114 IEDNFAQFKQLVQESRTLNITICFSIAVSFGCPYEGKVSPVKVISLVERAIEAGANRIGI 173 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G +++ + + +H H +G+AN+ AA+E G + S + Sbjct: 174 ADTIGIATPKQVKELLTEVL-HIAKSIPIAIHLHDTRGMGLANAYAALEAGVKIFETSAS 232 Query: 226 GMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADD 263 G+G AGN E + +++G + G D L+DAAD Sbjct: 233 GIGGCPFAPGAAGNLATEDLVYMFERMGVKTGIDFEKLLDAADF 276 >UniRef50_A7LNE9 Pyruvate carboxylase n=5 Tax=cellular organisms RepID=A7LNE9_TOXGO Length = 1391 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 62/372 (16%), Positives = 111/372 (29%), Gaps = 41/372 (11%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDA--RVDSIEVAHGDGLQGSSFN 58 K+L + D TLRD ++ + ++ ++A + + S+E G + Sbjct: 773 TEKRLLLCDTTLRDAHQSLLATRMRTIDMLKVAPSYAHLLPTLFSMENWGGATFDVA--- 829 Query: 59 YGFGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVR 108 Y F S +E + V + LL P + A + G + R Sbjct: 830 YRFLRESPWRRLELLREAVPNIPFQMLLRGTNAVGYTACPDNSVEAFCREAVKYGMDIFR 889 Query: 109 VATHCTEADVSAQHIQYARELGMDTVGFLMMSHM--------TTPENLAKQAKLMEGYGA 160 V + I A G + + T + + A + Sbjct: 890 VFDSLNFVENLKLGIDAAGAAGGVVEAAMAYTGNVADPDRKPYTLDYYLELASQLVATHC 949 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + V D G + AL+ E P +H H GVA+ +AA E G D + Sbjct: 950 HILCVKDMAGLLTPPAADLLISALRREF-PHIPIHVHTHDTGGCGVASMLAAAEAGADIV 1008 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETL 280 D ++ + + +A+ DL L +D + ++ + Sbjct: 1009 DVAVDSLSGLTSQPCMGSLVASLQHTPLDTEIDLNVLSQFSD-YFQQVRRFYAPFEATAT 1067 Query: 281 A------LGYAGVYSSFLRHC------ETAAARYGLSAVDILVE---LGKRRMVGGQEDM 325 + + + A R+ V LG V + Sbjct: 1068 VKNVSSEVHEHEIPGGQYTNLYMQAYSLGMADRWRDIKRAYCVANRLLGNPPKVTPSSKV 1127 Query: 326 IVDVALDLRNNK 337 + D A L NK Sbjct: 1128 VGDFAQFLVQNK 1139 >UniRef50_A4TE53 Pyruvate carboxylase n=40 Tax=Actinobacteria (class) RepID=A4TE53_MYCGI Length = 1148 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 65/371 (17%), Positives = 117/371 (31%), Gaps = 42/371 (11%) Query: 3 GKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDA--RVDSIEVAHGDGLQGSSFNY 59 K + ++D T RD ++ + + +A + ++ SIE G + Sbjct: 524 SKAVGVTDTTFRDAHQSLLATRIRTSGMLMVAPYVARMTPQLLSIECWGGATYDVA---L 580 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRV 109 F E + A + V + + LL P T ++ A G + R+ Sbjct: 581 RFLKEDPWERLAALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEATATGIDIYRI 640 Query: 110 ATHCTEADVSAQHIQYARELGMDTVGFLM---------MSHMTTPENLAKQAKLMEGYGA 160 D I RE G M ++ T + K A+ + GA Sbjct: 641 FDALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSDPAENLYTLDYYLKLAEQIVDAGA 700 Query: 161 TCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRI 220 + + D G + RAL++ + +H H +A +AA + G + Sbjct: 701 HVLGIKDMAGLLRPQAADTLVRALRSRF--DLPVHVHTHDTPGGQLATYLAAWQAGASAV 758 Query: 221 DASLAGMGAGAGNAPLEVFIAAADKLGWQHGT------DLYALMDAADDLVRPLQDRPVR 274 D + + + L +AA + G DL +A + P Sbjct: 759 DGASSPLAGTTSQPALSSIVAATAHTEFDTGLSLEAVCDLEPYWEALRKVYAPFDVAAAG 818 Query: 275 VDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVE---------LGKRRMVGGQEDM 325 T + + + L + A GL +E LG+ V + Sbjct: 819 PTTPTGRVYHHEIPGGQLSNLRQQAIALGLGDRFEQIEASYAAADRILGRLVKVTPSSKV 878 Query: 326 IVDVALDLRNN 336 + D+AL L Sbjct: 879 VGDLALALVGA 889 >UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO Length = 495 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 64/353 (18%), Positives = 123/353 (34%), Gaps = 36/353 (10%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TL G + LE +IA LD VD IE +G + Sbjct: 2 IRIFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGEKRVVREVVRN 61 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH--- 122 + ++ L D+K A + G V + + + + Sbjct: 62 VK----RLSRSGLSPEVCAL---ARAIREDVKAAVETGVDSVNIFIPASRLLLERAYGMR 114 Query: 123 -----------IQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + A+ + + + + L ++ E GA I + D GA Sbjct: 115 EEEARERVREAVSLAKSHDLTVEFTAEDAGRSD-DLLWDLCRIAEESGADRINLSDPVGA 173 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 M D + K ++ + ++L + ANS++A G D+I S+ G+G A Sbjct: 174 MLPDDAKKIVLEAKKRIRK--PISVTFSNDLGMATANSLSAAIAGADQIHVSVNGLGPKA 231 Query: 232 GNAPLEVFIAAADKL-GWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAG 286 G APLE + KL G + L ++ + R P+ + V + AG Sbjct: 232 GIAPLEQVVVGLKKLAGLDTNVKMELLPSVSEAVERISGIPISEISPIVG-PLVFTYEAG 290 Query: 287 VYSSFLRHCETAAARYGLSAVDILVE----LGKRRMVGGQEDMIVDVALDLRN 335 V+ S + + ++ +S ++ +G ++++ ++ + Sbjct: 291 VHVSAISN--ELSSYEIVSPGEVGRVRRFWVGTHSGRKAVKEVLKEMGYSASD 341 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 56/313 (17%), Positives = 104/313 (33%), Gaps = 35/313 (11%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G ++LE ++IA +L VD IE+ + F Sbjct: 2 LIDTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGWVGQDDLALFAGYARTLGGD 61 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQ------ 121 L + D++ A + G + + + ++ + + Sbjct: 62 ---------------TALSVWSPCREKDIEVAAELGLKRINIGVPVSDLHIEKRLDSDRQ 106 Query: 122 --------HIQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 ++ A++ G + L + A E GA+ + + DS G + Sbjct: 107 AILRKLAAAVRTAKDCGFEYVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQL 166 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + R + +L +H H + + ANS A+E G D D S+ G+G +G Sbjct: 167 TPLAMEKLVRKFREKL--HIDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSG 224 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDL---VRPLQDRPVRVDRETLALGYAGVYS 289 A E +A L DA + + R V + +G+++ Sbjct: 225 IAATEELVARLALREGNTRYSTTVLKDACMVVGAAAKVAIPRTKAVVGTDIFACESGLHT 284 Query: 290 SFLRHCETAAARY 302 L Y Sbjct: 285 HALSKSPELFEPY 297 >UniRef50_C5S7B1 Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=C5S7B1_CHRVI Length = 327 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 134/314 (42%), Gaps = 21/314 (6%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQ-GSSFNYGF 61 +L + D T+RDG HQ+S + VR + +A +A +D +E+ + + + +G Sbjct: 11 RPELKVLDCTVRDGGLVNAHQFSDDFVRAVYRACVEAGIDYMEIGYKNSPKVFPKEKFGP 70 Query: 62 GAHSDLEWIEAAA----DVVKHAKIATLLLPGIGTIHD-LKNAWQAGARVVRVATHCTEA 116 H D ++ K+A + G + A ++ ++RVA + + Sbjct: 71 WRHCDEADLKRVVGDHDPEKTGLKLAAMADAGKSDWETQIVPAAESPLSMIRVAFYAHQV 130 Query: 117 DVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSD 176 + I+YA +LG +T LM T + + + AT + +VDS G + Sbjct: 131 SEAVDMIRYAHDLGYETTANLMAVSNITEAEIDTVLESIAPTPATTMVIVDSFGYLYREQ 190 Query: 177 IRDRFRALKAEL-KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAP 235 I +R + L + G+HAH+NL L AN+I A+ GC+R+DA++ G G GAGN Sbjct: 191 IDRLYRKYTSALEGTGKEIGIHAHNNLQLAFANTIEAIILGCNRVDATMYGFGRGAGNCH 250 Query: 236 LEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVY--SSFLR 293 E+ + ++ + +++ + PL+ L G + Y + L Sbjct: 251 TELLLGFLRNPKFE----VRPVIEVIQKYLFPLRR--------ELDWGPSIPYNLTGQLN 298 Query: 294 HCETAAARYGLSAV 307 +A + Sbjct: 299 QHPRSAIEWREGPT 312 >UniRef50_B6QTB6 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase n=2 Tax=Trichocomaceae RepID=B6QTB6_PENMQ Length = 564 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 103/310 (33%), Gaps = 35/310 (11%) Query: 1 MNGKKL---YISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSF 57 M K+ I +V RDG+ +I+ E ++ + L A + SIE+ + Sbjct: 1 MTRPKVPEVRIVEVGPRDGLQSIKDAVPTETKTELIQRLWRAGLRSIELTSIVSTRKVPQ 60 Query: 58 NYGFGAHSDLEWIEAAAD--VVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 + I + + ++ L + L A G + V V TE Sbjct: 61 LADCQEILNNPAIRSLTEDSEASGLRLPVLT----PNLKGLDIALSRGVKEVAVFISATE 116 Query: 116 --------------ADVSAQHIQYARELGMDTVGFL------MMSHMTTPENLAKQAKLM 155 + + Q A E G+ G++ T P ++ + + + Sbjct: 117 GFSQANINCSVEQGVEKARAVAQKAIEAGIAVRGYVSCIFVDPYDGPTNPSSVLRCVQEL 176 Query: 156 EGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEE 215 G + + D+ GA + + R L+ H H VAN + A Sbjct: 177 LQMGCYEVSLGDTTGAGTPAKVATLIRYLEKNGVSLRNLAGHFHDTYGQAVANVLQAYIC 236 Query: 216 GCDRIDASLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQ 269 G DAS+ G+G GN E + G Q G +L L+ + + + ++ Sbjct: 237 GIRVFDASVGGLGGCPFAPGAKGNVSTEEVVFMFQNAGIQTGVNLEELVATGNWINQQVR 296 Query: 270 DRPVRVDRET 279 V + Sbjct: 297 GSSESVQSDF 306 >UniRef50_Q49WN9 Pyruvate carboxylase n=48 Tax=Bacteria RepID=Q49WN9_STAS1 Length = 1151 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 56/365 (15%), Positives = 113/365 (30%), Gaps = 39/365 (10%) Query: 6 LYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 + I+D T RD ++ + +++ IA DS + G++F+ + Sbjct: 533 VLITDTTFRDAHQSLLATRVRTKDMMNIASKTAQVMKDS---FSLEMWGGATFDVAYNFL 589 Query: 65 SDLEW--IEAAADVVKHAKIATLLLPGIGT----------IHDLKNAWQAGARVVRVATH 112 + W +E + + LL +K + +AG V R+ Sbjct: 590 KENPWKRLERLRKEIPNVLFQMLLRASNAVGYKNYPDNVIKKFVKESSEAGIDVFRIFDS 649 Query: 113 CTEADVSAQHIQYARELGMDTVGFLMMSH---------MTTPENLAKQAKLMEGYGATCI 163 D + +E G + G + + + T + AK +E G + Sbjct: 650 LNWVDQMKVANEAVQEAGKISEGTICYTGDILNPNRSDIYTLQYYVDMAKTLEREGFHIL 709 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D G + + LKA + + +H H G+ A++ G D ID + Sbjct: 710 AIKDMAGLLKPKAANELIGELKAAV--DLPIHLHTHDTSGNGLLVYKQAIDAGVDVIDTA 767 Query: 224 LAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADD---LVRPLQDRPVRVDRETL 280 +A M A + D+ + + + + + D + Sbjct: 768 VASMSGLTSQPSGNSLYYALNGFDRNMRADVDGMEELSHYWGTVRQYYSDFESDIKSPNT 827 Query: 281 ALGYAGVYSSFLRHCETAAARYGLS---------AVDILVELGKRRMVGGQEDMIVDVAL 331 + + + A GL + G V ++ D+AL Sbjct: 828 EIYKHEMPGGQYSNLSQQAKSLGLGNRFNEVKEMYRRVNFLFGDIVKVTPSSKVVGDMAL 887 Query: 332 DLRNN 336 + N Sbjct: 888 YMVQN 892 >UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM Length = 418 Score = 180 bits (458), Expect = 4e-44, Method: Composition-based stats. Identities = 55/356 (15%), Positives = 120/356 (33%), Gaps = 37/356 (10%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 +++ + D T+R+G + + + IAKALD+ +D IE+ F Sbjct: 37 PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL------------IPFL 84 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGA-----------RVVRVAT 111 + D E + D+ +AK+ + + G +V Sbjct: 85 SKDDEEAAKELVDMGLNAKLLSFVSWKKEDTDLALKLDLEGVVLDFVGNPWQGKVFWNLK 144 Query: 112 HCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 + YA++ G+ V + + + K + I + D+ G Sbjct: 145 PEEIIERGVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDTYGD 204 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + + LK +T +H H++ L A ++ AV G + + ++ G+G Sbjct: 205 ALPWAMEYVMKRLKKA-ADKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLGERV 263 Query: 232 GNAPLEVFIAAADK-LGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSS 290 G LE A + LG + +L L + + +V + V V++ + + Sbjct: 264 GLLSLEEIAVALEFLLGVKTNINLEKLYEIS-KIVEEISKVKVAVNKPIVGANQFKYTAG 322 Query: 291 FLRHCETAAARYGLSA-----------VDILVELGKRRMVGGQEDMIVDVALDLRN 335 ++ A G + + K + + ++ + + + Sbjct: 323 WITWMHRKAREAGKLTGMLPFMPEAVGRQLDYVVSKGSGASFVAEKLAELGITVED 378 >UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO Length = 662 Score = 180 bits (458), Expect = 4e-44, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 109/344 (31%), Gaps = 34/344 (9%) Query: 9 SDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLE 68 D TLRDG + + ++ +A+ L V IE + + S L Sbjct: 67 YDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTSSGLA 126 Query: 69 WIEAAADVVKHAKIATLLLPGIGTIHD----------------LKNAWQAGARVVRVATH 112 AAA K A G+ D + AW V + Sbjct: 127 D-RAAAGGTKLAAFGMTRRRGVTADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLGVSP 185 Query: 113 CTEADVSAQHIQYARELGMDT---VGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSG 169 + + + + G + PE K A GA + + D+ Sbjct: 186 EENIAMIEESVAHLVAAGKEVLVDCEHYFDGRKANPEFAVKCAAAAAKSGAKFVVLCDTN 245 Query: 170 GAMNMSDIRDRFRALKAEL---KPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 G D+ + R +K + + G+H H++ SL VANSIAAV G + + G Sbjct: 246 GGTLPWDVEEFTREVKEAVDATGADCSVGIHCHNDTSLAVANSIAAVRGGATMVQGCVNG 305 Query: 227 MGAGAGNAPLEVFIAAADKLGWQHGT------DLYALMDAADDLVRPLQDRPVRVDRETL 280 G GNA L V A + + L + A L QD + Sbjct: 306 YGERTGNADLLVVAANLELKMGRTALPEGSLQRLTQVSAAVAKLCSQHQDPRQPYMGSSA 365 Query: 281 ALGYAGVYSSFLRHCET-----AAARYGLSAVDILVELGKRRMV 319 G++ + L+ G A ++ EL R + Sbjct: 366 FAHKGGLHVAALQKMPASYNHIVPTLVGNEARSVISELSGRGNI 409 >UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT Length = 543 Score = 180 bits (458), Expect = 4e-44, Method: Composition-based stats. Identities = 59/348 (16%), Positives = 117/348 (33%), Gaps = 27/348 (7%) Query: 1 MNG--KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFN 58 M +++ + D TLRDG + +S E+ ++IA+ L +D IE Sbjct: 3 MTTDVRRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDDCF 62 Query: 59 Y-----GFGAHSDLEWI----EAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRV 109 + +HS L + +A L+ G + +W Sbjct: 63 FELMRDRAWSHSRLVAFGSTARPGHPASEDPGLARLVACGADAVCIFGKSWDLHVTTGLG 122 Query: 110 ATHCTEADVSAQHIQYARELGMDTVG---FLMMSHMTTPENLAKQAKLMEGYGATCIYVV 166 T D+ + + + + + + + + GA + + Sbjct: 123 IDLQTNLDLVRESVAWLKLHVDTVLFDAEHFFDGYAANRDYAMQVLAAAADAGADSLVLC 182 Query: 167 DSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAG 226 D+ G I R + A P+ G+HAH++ + VAN+++AV G + ++ G Sbjct: 183 DTNGGSLPEQIGACVRQVVAR-YPDLTIGIHAHNDSEMAVANAVSAVSAGASHVQGTING 241 Query: 227 MGAGAGNAPLEVFIAAAD-KLGWQHGTDLYALMDA------ADDLVRPLQDRPVRVDRET 279 +G GN L I K+G G +L +++ L + + Sbjct: 242 LGERCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQN 301 Query: 280 LALGYAGVYSSFLRHC-----ETAAARYGLSAVDILVELGKRRMVGGQ 322 G++ S +R A G + ++ R + + Sbjct: 302 AFAHKGGIHVSAVRKASHLYEHIDPASVGNAQRVLVSNQAGRSNILAK 349 >UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD Length = 301 Score = 180 bits (457), Expect = 5e-44, Method: Composition-based stats. Identities = 52/307 (16%), Positives = 104/307 (33%), Gaps = 41/307 (13%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+++++ +V RDG+ + E ++ + L DA V IEV+ + Sbjct: 2 GERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSFVHPK------WIP 55 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS--- 119 +D + + A +++ L + L A A V V +E+ Sbjct: 56 QLADADEVFARIRRRPGVELSAL----VPNERGLARALAAKVDAVHVFMSASESHNLKNI 111 Query: 120 -----------AQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 I+ A+ G+ G+ + + + G Sbjct: 112 NKTIADTYPVLRPVIEGAKAEGLVVRGYVSTVFGCPYEGKVPVSQVLSVVERLFELGVDE 171 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D+ G + + + R + + P + +H H + +AN A G R D Sbjct: 172 VALGDTIGVAVPTQVAEVVREV-ERIVPLDRVSLHFHDTRGMAIANMYAGFAAGVRRFDG 230 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRP 272 S+ G+G GN +E + + + + G + +D L +PL Sbjct: 231 SIGGLGGCPYAPGASGNVAMEDVLYLFNGMDVETGIEAERYLDVVAWLESKLNKPLASHA 290 Query: 273 VRVDRET 279 +V R Sbjct: 291 RQVARSA 297 >UniRef50_C5EHC6 Pyruvate carboxylase subunit B n=2 Tax=Clostridiales RepID=C5EHC6_9FIRM Length = 465 Score = 180 bits (457), Expect = 6e-44, Method: Composition-based stats. Identities = 63/338 (18%), Positives = 113/338 (33%), Gaps = 23/338 (6%) Query: 2 NGKKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG 60 G + + V RDG ++ + + ++ + A+D DS+E+ G + Sbjct: 21 TGSPVRFNSVEFRDGQQSLFATRMTTADMVPLLSAMDQVGYDSMEMWGGATFDVA---VR 77 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 F + I VK + +L P ++ A AG V + Sbjct: 78 FLKEDPWDRIREFKKYVKRTPLKMVLRGQNLVGYKAYPDDVVEKFVEKAAAAGIDVFLIF 137 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMM--SHMTTPENLAKQAKLMEGYGATCIYVVDS 168 + + ++ G G + S T E + K E G + ++V D Sbjct: 138 DALQDLRNCESAFRAVKKAGKKIEGSIQYNISPFHTIEKFVENGKEQEKMGVSLLHVEDM 197 Query: 169 GGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMG 228 G M + D +ALKAELK +H H + A+ G D +D ++ M Sbjct: 198 AGLMTPAAAYDLIKALKAELK--VPIHLHCHCTGGMAEMAYWEAIRAGVDGLDVCVSSMS 255 Query: 229 AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAAD---DLVRPLQDRPVRVDRETLALGYA 285 G + P+E F+ A D+ + L R ++ + Sbjct: 256 MGPAHPPIESFVTALKGTSRDPHIDVAQFKAINEGFLALRRKYAQFETKLIGVDVGCLEH 315 Query: 286 GVYSSFLRHCETAAARYGLSAV--DILVELGKRRMVGG 321 + L + E+ L +L E+ + R G Sbjct: 316 QIPGGMLSNLESQLTAMKLYDRLPQVLEEVTRVRADMG 353 >UniRef50_C0CL40 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CL40_9FIRM Length = 528 Score = 180 bits (457), Expect = 6e-44, Method: Composition-based stats. Identities = 57/335 (17%), Positives = 120/335 (35%), Gaps = 8/335 (2%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + D TLRDG + ++ + + Q + L + VD +E+ F Sbjct: 4 IQTLDCTLRDGGYLNDWEFGYKMICQTVRQLIASNVDYVELGFLRNEDYQPDRTVFRHVK 63 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQY 125 D I K+ + + L I L++ + +RV H + + ++ + Sbjct: 64 DAYHI--LPKDCKNTRFTLMSLHNKYDISQLEDYDGGPIQRIRVTFHDYDVEEGLEYCRK 121 Query: 126 ARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALK 185 E G + + + L + + + T +VD+ G+M +D+ + + Sbjct: 122 VMEKGYEVACNPINIMGYSDGELLEILRKVNEIHPTVFSIVDTFGSMKRNDLIRLYSLCE 181 Query: 186 AELKPETQTGMHAHHNLSLGVANSIAAVEEGCD----RIDASLAGMGAGAGNAPLEVFIA 241 L + G+H H NLSL + + + ID SL GMG GN +E+ + Sbjct: 182 NNLSKDITIGLHLHENLSLSYSLAQEFLNIKSYSRNCVIDGSLLGMGRVPGNLCIELILD 241 Query: 242 AADKLGWQHGTDLYALMDAADDLVRPLQD-RPVRVDRETLALGYAGVYSSFLRHCETAAA 300 + + ++ ++DA DD + P++ P ++ ++ Sbjct: 242 YLNNNYAKT-YNIDPILDAIDDYIVPIKRLEPWGYSTAYSLSAKYNLHRNYAEFLLNKGK 300 Query: 301 RYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRN 335 IL + + E + ++ ++ Sbjct: 301 LKAKDINHILASIEDCKKTAFDEAYVEELYYHYQD 335 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 180 bits (456), Expect = 7e-44, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 99/275 (36%), Gaps = 27/275 (9%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I D TLRDG +S + QIA+ L++ VD+IE+ + Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPG-----------RYAK 55 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQ-AGARVVRVATHC----------- 113 D++ I A + V+K + + L I+ + + A + + T Sbjct: 56 DIDEIIAVSQVIKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDK 115 Query: 114 -TEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + I A+ + L + + GA I + DS G Sbjct: 116 NSILSTLKKQISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVA 175 Query: 173 NMSDIRDRFRALKAELK--PETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAG 230 D + + L + +H H++L V NS+ +E G +I+ ++ G+GA Sbjct: 176 LPEDFYNLLQKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGAR 235 Query: 231 AGNAPLEVFIAAAD-KLGWQHGTDLYALMDAADDL 264 GNA L + + + + ++ + Sbjct: 236 KGNANLTKVVNLIQSHHSYYTTINHNLIPKISELI 270 >UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI Length = 506 Score = 180 bits (456), Expect = 7e-44, Method: Composition-based stats. Identities = 64/355 (18%), Positives = 115/355 (32%), Gaps = 23/355 (6%) Query: 1 MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKAL-DDARVDSIEVAHGDGLQGS---- 55 M + + I D TLRDG +S +A+ L + +VD +E+A G Sbjct: 1 MKRRYIEIMDTTLRDGEQTSGVSFSASEKLALAQLLLTEVKVDRVEIASARVSAGELEAV 60 Query: 56 -SFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCT 114 + ++ +E V A + L G ++ L T Sbjct: 61 QQITRWADSIGLIDKVEVLTFVDGQASLDWLQASGAKVMNLLTKGSLNHLTHQLKKTPGE 120 Query: 115 EADVSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 Q + A +LG+ +L +P+ + + + + + D+ G Sbjct: 121 HFTDIGQVVCAAGKLGVKANVYLEDWSNGMRNSPDYVFQYLDFLNTQPILRVLLPDTLGV 180 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + ++ L P HAH++ L +AN + A+ G I ++ G+G A Sbjct: 181 LTPAESYSFVHQLVTR-YPNLHFDFHAHNDYDLSIANVMEAIRAGAHGIHLTVNGLGERA 239 Query: 232 GNAPLEVFIAAADKL--GWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYA 285 GNAPL IA + G +L + + + D V Sbjct: 240 GNAPLASAIAVLRDFMPEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVGDNVFTQTAG 299 Query: 286 GVYSS----FLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L R+G LGK E+ + ++ + L + Sbjct: 300 IHADGDKKNNLYFNALLPERFG---RKRSYALGKMSGKANIENNLRELGIQLSED 351 >UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT Length = 304 Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats. Identities = 51/302 (16%), Positives = 95/302 (31%), Gaps = 40/302 (13%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 D T+RDG + + I L V IEV Sbjct: 20 FVDTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPCLGDHE------------ 67 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA------- 120 IE ++ L D ++A G + V V+ ++A ++ Sbjct: 68 --IEDLRALLSLPVPVELFPWLRPLEADFESALGLGFKRVHVSFPTSDAHRASVQNMGRP 125 Query: 121 QHIQYARE-------LGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMN 173 ++ R+ G L + + L + + G + D+ G + Sbjct: 126 DIVERVRKTVLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHH 185 Query: 174 MSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGN 233 ++I +R L E +H H++L + AN+++A G + ++ G+G AGN Sbjct: 186 PAEIIERISELSKE---GLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGN 242 Query: 234 APLEVFIAAADKLGWQHG------TDLYALMDAADDLVRPLQD---RPVRVDRETLALGY 284 A +E A DL L + L ++ + + Sbjct: 243 AAMEEVAFALACERGDPSLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHS 302 Query: 285 AG 286 +G Sbjct: 303 SG 304 >UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA Length = 303 Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 109/293 (37%), Gaps = 34/293 (11%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 MN +K+ I +V RDG I+ ++ +I +L++A + IE+ + Sbjct: 1 MNLPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEITSFVNPK------ 54 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS 119 D + I K ++L ++NA +GA V+ V +EA Sbjct: 55 WIPQMVDSKEICETCVKKNERKYEVIVLC--PNKKGIENAISSGAEVISVVISVSEAHNK 112 Query: 120 AQHIQYARELGMD------------------TVGFLMMSHMTTPENLAKQAKLMEGYGAT 161 A + E + TV PE +++ + + G Sbjct: 113 ANVNRTVEESFKELEEMVYKYPNMKFRLDLATVFGCPFGEEIKPERVSELIEKAKKIGVK 172 Query: 162 CIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRID 221 I + D+ G N + + +K ++ E +H H +G+AN + A++ G + Sbjct: 173 EIMLADTVGLGNPVLVEKILKQVKEQVGTENII-LHIHDTRGMGLANMLVALQLGYSIFE 231 Query: 222 ASLAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 S+ G+G AGN E F+ + +G H L L D + + + Sbjct: 232 TSIGGLGGCPFAPGAAGNVATEDFVNMLNGMGINHNIHLEKLYHTLDLIDQYV 284 >UniRef50_Q1YPG1 Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YPG1_9GAMM Length = 304 Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 115/299 (38%), Gaps = 19/299 (6%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYG-- 60 + + I+DV RDG+ S+E Q+ A+ D V IEV + G Sbjct: 2 SETVVITDVGPRDGLQNQPQVLSVEQRLQLVNAIADCGVPQIEVGSFVSPKAVPAMAGTG 61 Query: 61 --FGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADV 118 F A E++ ++ + K L + G V EA++ Sbjct: 62 QVFSALDAAEFVTPTIALIPNMKGYELARESGVKTVTMVVYASDGMAQKNVGMSMAEAEL 121 Query: 119 S-AQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGA 171 ++ A+E G++ + T P + GA + + D+ GA Sbjct: 122 VTLDILKLAKEDGIEVIATIAVAFECPFDGATDPAVVKNIVAKFLAAGADQLVLADTVGA 181 Query: 172 MNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGA 231 + +R+ L A E Q G H H ++G+AN AAVE G R D+S+AG+G Sbjct: 182 AHPQQVRELTATLVASHGAE-QLGCHFHDTRAMGLANVYAAVESGIRRFDSSIAGLGGCP 240 Query: 232 ------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGY 284 GN + ++G++ G DL LM A+D L + L +T GY Sbjct: 241 FSPGASGNVATDDIAMMLQQMGFKTGIDLGKLMQASD-LAQRLTGTAPGGRSKTWLQGY 298 >UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=76 Tax=cellular organisms RepID=HMGCL_ARATH Length = 468 Score = 180 bits (456), Expect = 9e-44, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 104/294 (35%), Gaps = 37/294 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 K + I +V RDG+ ++ ++ + L + + +E + Sbjct: 165 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPK------WVP 218 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS--- 119 +D + + A + + A++ L + + A AGA+ V + +E+ Sbjct: 219 QLADAKDVMDAVNTLDGARLPVL----TPNLKGFQAAVSAGAKEVAIFASASESFSLSNI 274 Query: 120 -----------AQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATC 162 A+E + G+ + P +A K + G Sbjct: 275 NCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFE 334 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 I + D+ G + A+ A + + + +H H +AN + +++ G +D+ Sbjct: 335 ISLGDTIGIGTPGSVVPMLEAVMAVVPAD-KLAVHFHDTYGQALANILVSLQMGISIVDS 393 Query: 223 SLAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 S+AG+G GN E + + LG DL L+ A D + + L Sbjct: 394 SIAGLGGCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGR 447 >UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK Length = 338 Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 107/332 (32%), Gaps = 41/332 (12%) Query: 3 GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFG 62 G+ ++I+DV +RDG+ + + ++ IE + Sbjct: 9 GESVWINDVVMRDGLQMEPVFVPTSEKVALIDEIGHCGLNRIEATSFTSAKA------IP 62 Query: 63 AHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSA-- 120 A SD E + + V + A L+L + A + G + + +E A Sbjct: 63 ALSDAEAVMHEIERVPGVRYAALVL----NRRGAERALECGVDELNLGVSASETHNLANT 118 Query: 121 -----QHIQYARELGMDTV------------GFLMMSHMTTPENLAKQAKLMEGYGATCI 163 Q ++ ++ M +++ G I Sbjct: 119 RMTRAQAVRALLDITAFCRDRLAIGVSIATAFGCPMEGAIDIDSVLDIGNQFVAAGVRGI 178 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + D+ G N ++ AL A + + +H H+ +G+AN +A ++ G DAS Sbjct: 179 TLCDTTGMANPRQVKAVCGALAARWR-GIELTLHLHNTRGMGLANVVAGLDAGIRHFDAS 237 Query: 224 LAGMGAGA------GNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDR 277 L G+G GN E + D +G+ G DL L+ A V Sbjct: 238 LGGLGGCPFAPGASGNICTEDLVHMLDAMGYATGVDLERLIACARR-----MPGLVGHGV 292 Query: 278 ETLALGYAGVYSSFLRHCETAAARYGLSAVDI 309 F + A R A ++ Sbjct: 293 PGQVQHAGAWDHRFPPPADLEATRERALAREL 324 >UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD Length = 373 Score = 179 bits (453), Expect = 1e-43, Method: Composition-based stats. Identities = 56/348 (16%), Positives = 110/348 (31%), Gaps = 43/348 (12%) Query: 8 ISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDL 67 + D TLR+G E +IA + D V+ IE+ Sbjct: 2 LIDTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGWMG------------QEGLD 49 Query: 68 EWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVS-------- 119 E ++A ++ D+ A + + ++ ++ Sbjct: 50 EVVKALRGRGVTCDLSV---WSPCRTVDVYRAAGLSIDTINIGLPVSDLHIAERLRTDRD 106 Query: 120 ------AQHIQYARELGMD-TVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 + + A G+ L + A++ + GA I + D+ G M Sbjct: 107 GLTRMLRETVGLAHSCGIRRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVM 166 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + I + R + + + +H H++ + AN+I A+E G D S+ G+G +G Sbjct: 167 TPTRIAELVRFFAQSV--DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSG 224 Query: 233 NAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR----PLQDRPVRVDRETLALGYAGVY 288 + LE + D+ + D + P+ + A Sbjct: 225 ISALEEVAGHLRLVQGYDIYDMNLVRALCDLVAEYARIPVARNRPMSGGDIFAAESGLHV 284 Query: 289 SSFLRHC----ETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALD 332 L++ A+ G ++ LG + G M+ V L Sbjct: 285 DGILKNPALFEPYDPAQTGAKR---ILALGAKAGRGAVRTMLRQVGLK 329 >UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGI7_9FIRM Length = 307 Score = 179 bits (453), Expect = 1e-43, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 106/291 (36%), Gaps = 37/291 (12%) Query: 6 LYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHS 65 + I +V LRDG+ + + E+ ++A+AL A + IE+ + Sbjct: 11 VLIREVGLRDGLQNEKQFVATEDKIRLARALTAAGLREIEITSFVSPKA------VPQMR 64 Query: 66 DLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQH--- 122 D + I AA + + L + ++A +G + ++ C+E Sbjct: 65 DAKEIVAALGQPEGVTYSAL----VVNRRGAEDAIASGVKELQYVVSCSETHSQKNVRMS 120 Query: 123 -----------IQYARELGMDTV------GFLMMSHMTTPENLAKQAKLMEGYGATCIYV 165 A+E G+ T+ + + + + G + + Sbjct: 121 VDEALQQAAIISDLAKENGLTIRTALSATFGCPFEGKTSYDRVYDLLEKLFSLGVERVSL 180 Query: 166 VDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLA 225 D+ G N + + + A + + +H H LG+A ++A V G I++S+ Sbjct: 181 SDTAGLGNPRQVAQLCQGIVARFPED-RFSLHLHDTRGLGLACTLAGVWAGIRVIESSIG 239 Query: 226 GMGA------GAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQD 270 G+G GN E + +++G G D LM+AA + L Sbjct: 240 GLGGCPFVPNATGNIATEDVVYMMEEMGISTGLDWQQLMNAAMMAEKILGR 290 >UniRef50_Q039M6 Pyruvate carboxylase n=9 Tax=Lactobacillaceae RepID=Q039M6_LACC3 Length = 1145 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 53/365 (14%), Positives = 105/365 (28%), Gaps = 37/365 (10%) Query: 4 KKLYISDVTLRDGMHAI-RHQYSLENVRQIAKALDD--ARVDSIEVAHGDGLQGSSFNYG 60 +L ++D T RD ++ + ++ +A+ + + + S+EV G + Y Sbjct: 526 NQLLLTDTTFRDAHQSLFATRMRTRDMLTVAQDMGNGLPNLFSMEVWGGATFDVA---YR 582 Query: 61 FGAHSDLEWIEAAADVVKHAKIATLLL----------PGIGTIHDLKNAWQAGARVVRVA 110 F ++ + H + L P ++ A G V R+ Sbjct: 583 FLNEDPWTRLKKLRAALPHTLLQMLFRGSNAVGYQNYPDNVIKAFIQKAADDGVDVFRIF 642 Query: 111 THCTEADVSAQHIQYARELGMDTVGFLMMSH--------MTTPENLAKQAKLMEGYGATC 162 I ++ G + + AK + GA Sbjct: 643 DSLNWLPQMTLSIDTVKQTGKLAEATMCYTGDILSHAHPKYQLAYYVDLAKQLVAAGADM 702 Query: 163 IYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDA 222 + + D G + + ALK + +H H G+A +AA G D +D Sbjct: 703 LAIKDMAGLLKPQAATELVTALKDAVS--VPIHLHTHDTTGNGIATYVAAANAGVDIVDV 760 Query: 223 SLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVR---PLQDRPVRVDRET 279 + + LE A Q + D V Sbjct: 761 AQSSFSGTTSQPSLESLYYALSGNQRQPDVAIEKAQKLNRYFQAIRPYYADFSNGVTGPL 820 Query: 280 LALGYAGVYSSFLRHCETAAARYGLSAVDILVEL--------GKRRMVGGQEDMIVDVAL 331 + + + + A G++ + + + G V ++ D+AL Sbjct: 821 TDIYTVQMPGGQYSNLQQQARSMGITDFEAVKTMYAQVNTLFGDIIKVTPSSKVVGDMAL 880 Query: 332 DLRNN 336 + N Sbjct: 881 FMLQN 885 >UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria RepID=C5S831_CHRVI Length = 534 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 68/353 (19%), Positives = 117/353 (33%), Gaps = 22/353 (6%) Query: 2 NGKKLYISDVTLRDGMHAIRHQYSLENVRQIAK-ALDDARVDSIEVAHGDGLQGSSFNY- 59 +G+++ I D TLRDG ++ +AK L+ RVD IEVA G + Sbjct: 19 SGRRVLIMDTTLRDGEQTQGVSFAPAEKLNLAKVLLEQVRVDRIEVASARVSSGEASAVA 78 Query: 60 ----GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE 115 +E +E V A + + G ++ L + R T Sbjct: 79 QIIDWARERGLVERVEVLGFVDGGASVDWICGAGGQVLNLLAKGSEKHCRGQLGKTLDEH 138 Query: 116 ADVSAQHIQYARELGMDTVGFLMM---SHMTTPENLAKQAKLMEGYGATCIYVVDSGGAM 172 A I A+ G+ +L + P+ + + + G + D+ G M Sbjct: 139 AADVRATIAAAQSRGLRVNLYLEDWSNGYRDNPDYVYGLVERLADVGIGHFMLPDTLGVM 198 Query: 173 NMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAG 232 + + P Q H H++ L AN +AAV+ G + ++ +G AG Sbjct: 199 TPDQVFTAISDMVGRF-PSLQFDFHPHNDYGLATANVLAAVQAGAAAVHCTVNCLGERAG 257 Query: 233 NAPLEVFIAAAD-KLGWQHGTDLYALMDAADDLV----RPLQDRPVRVDRETLALGYAGV 287 NA L +L G D L ++ + + + D V + Sbjct: 258 NASLAEVAVNLRDQLDCALGIDETHLARVSELVESFSGKRISDNAPIVGADVFTQTAGIH 317 Query: 288 YS----SFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNN 336 L H + R+ A LGK + + ++L Sbjct: 318 ADGDKKGSLYHSRLSPERF---ARRRKYALGKLAGKASLAKNLERLDIELSEE 367 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 66/325 (20%), Positives = 119/325 (36%), Gaps = 45/325 (13%) Query: 5 KLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAH 64 K+ I++V RDG+ + S+E+ + +AL + ++E + Sbjct: 2 KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGSFVSPKA------VPQM 55 Query: 65 SDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTE--------- 115 + + + A + A L + + + A AGA VV V TE Sbjct: 56 AGTDDLFALLPERSAVRYAGL----VPNMKGYELAVAAGANVVNVVLSVTETMNQKNIRM 111 Query: 116 -----ADVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATCIY 164 +V I+ R G++ + + P +A+ AK +E GA+ I Sbjct: 112 SLPQTVEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGASKII 171 Query: 165 VVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASL 224 + D+ GA N +R + +E+ + H H + +AN AA++ G D S+ Sbjct: 172 IADTIGAANPEHVRRLLNGVISEVGSDI-LSCHFHDTRGIALANITAALDHGIREFDTSI 230 Query: 225 AGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRE 278 G+G GN E + + +G G + + L+ L L P + + Sbjct: 231 GGLGGCPFSPGATGNVATEDVVLLLNSMGHDTGINPFDLVPVVC-LAEQLTGVP--LGGK 287 Query: 279 TLALGYAGVYSSFLRHCETAAARYG 303 + S L TA +G Sbjct: 288 SFRW-----LSQQLSKASTAGTSHG 307 >UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira RepID=B0SA13_LEPBA Length = 299 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 101/291 (34%), Gaps = 35/291 (12%) Query: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63 +K+ I++V RDG+ + S ++ + K L ++ IE+ Sbjct: 2 EKVKITEVGPRDGLQNEKTILSTQDKFEFIKRLVESGAKHIELTSFVRKDR------IPQ 55 Query: 64 HSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEA------- 116 +D + A V+ + A AG V V T +E+ Sbjct: 56 MADAMELSAL--VLPLYAKDVQFSCLTPNTKGYEGAKLAGFNEVAVFTATSESFTKKNIN 113 Query: 117 -------DVSAQHIQYARELGMDTVGF------LMMSHMTTPENLAKQAKLMEGYGATCI 163 + A++ G+ G+ PE + A+ + GA I Sbjct: 114 MTVKESFESFQPIFGLAKQDGIKVRGYISTVVACPYEGKIPPEKTLEVAERLLDAGAYEI 173 Query: 164 YVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDAS 223 + ++ G ++I L ++ P + H H + +AN+ A+ G D+S Sbjct: 174 SLGETIGVAVPNEIESLLSVLLKKI-PISYLNCHFHDTYGMAIANTKQALSMGIRSFDSS 232 Query: 224 LAGMG------AGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPL 268 G+G AGN E + + G+ G +L +L+ + + L Sbjct: 233 AGGLGGCPYAKGAAGNVATEDLVYFLSREGYDTGINLDSLIQVSQFMEAKL 283 >UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS Length = 518 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 55/368 (14%), Positives = 115/368 (31%), Gaps = 38/368 (10%) Query: 1 MN-GKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNY 59 M +K + DVTLRDG A+ ++ + + L V EV + + Sbjct: 1 MTETRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESV 60 Query: 60 GFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAG--ARVVRVATHCTEA- 116 A + E +V K+ ++ L D++ W+A A R+ T + Sbjct: 61 MELAKLTAQMAEEGDEVAKNVVVSGL---ARCIESDIQRCWEAVQYAPHPRIHTFLATSP 117 Query: 117 ---------------DVSAQHIQYARELGMD---TVGFLMMSHMT--TPENLAKQAKLME 156 + + + +++A+ L D + + K + Sbjct: 118 LSMENVLHMTPEQVKEKAVKCVKFAKSLVGDRGDVEFSAEHFGDCLENMDFVIDVLKAVV 177 Query: 157 GYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEG 216 GAT I + ++ D+ + + L +H H++L + A ++ + G Sbjct: 178 EAGATTINLPNTVERYRPKLYVDQVKQVYEALPKNITISVHCHNDLGMATAATVESFFVG 237 Query: 217 CDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLV----RPLQDRP 272 +++ +L G+G GN G G L + + A + P+ R Sbjct: 238 ATQLEVALNGLGERCGNTNFYEVAIGLHNSGVDTGLHLERIYETAILVSHWSGVPIYIRA 297 Query: 273 VRVDRETLALGYAGVYSSFLRHCETAAARYG-LSAVDILV------ELGKRRMVGGQEDM 325 + E + + + Y + I + ++ Sbjct: 298 PLIGTEAIVHRSGIHQDGASKTKDMKKGAYRPIDYSIIGRNQNDTLSFTSQSGRTAVYEI 357 Query: 326 IVDVALDL 333 I + Sbjct: 358 ITKFGYKM 365 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.314 0.140 0.354 Lambda K H 0.267 0.0428 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,620,656,167 Number of Sequences: 3077464 Number of extensions: 62944977 Number of successful extensions: 219682 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1171 Number of HSP's successfully gapped in prelim test: 273 Number of HSP's that attempted gapping in prelim test: 215694 Number of HSP's gapped (non-prelim): 1639 length of query: 337 length of database: 1,040,396,356 effective HSP length: 129 effective length of query: 208 effective length of database: 643,403,500 effective search space: 133827928000 effective search space used: 133827928000 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 93 (40.4 bits)