BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (332 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammap...   628   e-178
UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinoba...   388   e-106
UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemoph...   356   6e-97
UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria...   329   1e-88
UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID...   314   3e-84
UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteri...   308   2e-82
UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Ac...   293   6e-78
UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostri...   287   4e-76
UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   284   3e-75
UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococ...   275   2e-72
UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   255   2e-66
UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogen...   141   4e-32
UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5               140   6e-32
UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyru...   138   3e-31
UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. ...   137   4e-31
UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   136   1e-30
UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bact...   135   2e-30
UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriac...   135   2e-30
UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus So...   134   4e-30
UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteo...   134   4e-30
UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus...   134   4e-30
UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   134   6e-30
UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Co...   131   4e-29
UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococ...   128   3e-28
UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium ...   128   3e-28
UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostri...   127   4e-28
UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobia...   127   4e-28
UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerot...   126   8e-28
UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobi...   126   9e-28
UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobu...   125   2e-27
UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp...   125   3e-27
UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophu...   125   3e-27
UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaprot...   125   3e-27
UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia T...   124   4e-27
UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=...   124   4e-27
UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_P...   124   4e-27
UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2...   124   4e-27
UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoana...   124   4e-27
UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesen...   123   8e-27
UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha pro...   123   9e-27
UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclo...   123   1e-26
UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=A...   122   2e-26
UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonoc...   122   2e-26
UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangiu...   122   2e-26
UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q...   121   4e-26
UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B...   120   9e-26
UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   120   9e-26
UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomy...   119   1e-25
UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsi...   119   1e-25
UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium...   119   2e-25
UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfona...   119   2e-25
UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostri...   119   2e-25
UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella...   118   3e-25
UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobac...   117   4e-25
UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaeroba...   117   4e-25
UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunctio...   117   7e-25
UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitoba...   117   7e-25
UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobact...   117   8e-25
UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfito...   117   8e-25
UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...   116   1e-24
UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coeloma...   116   1e-24
UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2     115   2e-24
UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizo...   114   3e-24
UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...   114   3e-24
UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella ...   114   3e-24
UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   114   4e-24
UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyc...   113   7e-24
UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria...   113   1e-23
UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydro...   113   1e-23
UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxy...   112   1e-23
UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria ...   112   2e-23
UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Pro...   112   2e-23
UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistoso...   112   2e-23
UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostri...   111   3e-23
UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomi...   111   4e-23
UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella...   110   5e-23
UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Baci...   110   7e-23
UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyc...   110   7e-23
UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomy...   110   8e-23
UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organis...   110   8e-23
UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris ...   110   9e-23
UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaprot...   110   1e-22
UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax...   109   1e-22
UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostri...   108   2e-22
UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacte...   108   2e-22
UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   108   2e-22
UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenel...   108   3e-22
UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobac...   108   4e-22
UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=S...   107   4e-22
UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burk...   107   5e-22
UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacil...   107   6e-22
UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteoba...   107   6e-22
UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphapro...   105   2e-21
UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62...   105   3e-21
UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis...   104   4e-21
UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 ...   104   5e-21
UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine b...   104   6e-21
UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobact...   103   7e-21
UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria ...   103   7e-21
UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobac...   103   8e-21
UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=...   103   9e-21
UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH     102   1e-20
UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomi...   102   2e-20
UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN...   101   3e-20
UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IP...   101   3e-20
UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular ...   101   4e-20
UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular ...   100   5e-20
UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfo...   100   5e-20
UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...   100   6e-20
UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha prote...   100   6e-20
UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricauli...   100   1e-19
UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimon...    99   2e-19
UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochl...    99   2e-19
UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacte...    99   2e-19
UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=...    98   3e-19
UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobial...    98   5e-19
UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C...    98   5e-19
UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromon...    97   6e-19
UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family ...    97   8e-19
UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteoba...    96   1e-18
UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=...    96   2e-18
UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacte...    96   2e-18
UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba...    96   2e-18
UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...    96   2e-18
UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...    95   3e-18
UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...    94   5e-18
UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus ...    94   5e-18
UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia...    94   5e-18
UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...    94   5e-18
UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccu...    94   9e-18
UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholde...    93   1e-17
UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionace...    92   2e-17
UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria ...    92   2e-17
UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax...    92   2e-17
UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB...    91   7e-17
UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VE...    91   8e-17
UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacill...    91   8e-17
UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadec...    91   8e-17
UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...    90   1e-16
UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae...    89   2e-16
UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspi...    89   2e-16
UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=...    87   6e-16
UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...    87   6e-16
UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...    87   7e-16
UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria ...    87   8e-16
UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_...    86   2e-15
UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobial...    86   2e-15
UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lip...    86   2e-15
UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomon...    86   2e-15
UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=...    86   2e-15
UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate deh...    86   2e-15
UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evid...    85   3e-15
UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacter...    85   5e-15
UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogen...    84   5e-15
UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...    84   6e-15
UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME        84   9e-15
UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...    84   9e-15
UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax...    83   1e-14
UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...    83   2e-14
UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2...    82   2e-14
UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=...    82   4e-14
UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=...    81   4e-14
UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=...    81   7e-14
UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1...    80   8e-14
UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...    80   1e-13
UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=...    79   2e-13
UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=...    78   4e-13
UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaprot...    77   7e-13
UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria...    76   2e-12
UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...    75   3e-12
UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus...    75   3e-12
UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS          75   4e-12
UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NG...    74   5e-12
UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...    74   1e-11
UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=...    72   2e-11
UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium...    72   2e-11
UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...    72   3e-11
UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=...    72   4e-11
UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholde...    70   7e-11
UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Ta...    68   4e-10
UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacteri...    67   6e-10
UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...    67   7e-10
UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB...    66   2e-09
UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaprot...    66   2e-09
UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98C...    65   3e-09
UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata ob...    65   4e-09
UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3M...    65   4e-09
UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emerice...    63   1e-08
UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persepho...    59   3e-07
UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein...    58   5e-07
UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=...    57   7e-07
UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=...    57   1e-06
UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=...    53   1e-05
UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma p...    52   3e-05
UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...    51   6e-05
UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial ...    48   4e-04
UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rh...    44   0.008
UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicil...    42   0.040

>UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammaproteobacteria
           RepID=DLGD_SALNS
          Length = 332

 Score =  628 bits (1619), Expect = e-178,   Method: Compositional matrix adjust.
 Identities = 297/332 (89%), Positives = 319/332 (96%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVTFE+LK AF RVL SR +  +TAD CAEMFARTTESGVYSHGVNRFPRFIQQL+NGD
Sbjct: 1   MKVTFEELKGAFYRVLRSRNIAEDTADKCAEMFARTTESGVYSHGVNRFPRFIQQLDNGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           IIPDA+P+R+TSLGAIEQWDAQR+IGNLTAKKMMDRAIELA+DHGIGLVALRNANHWMRG
Sbjct: 61  IIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY
Sbjct: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           GMLEVNRLAGR+LPVDGGFDD G LTKEPGVIEKNRRILPMGYWKGSG+SIVLDMIATLL
Sbjct: 181 GMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL 240

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           S+G+SVAEVTQ+NSDEYG+SQIFIAIEVDKLIDG TRDAKLQRIMD++T+AERAD+N AI
Sbjct: 241 SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAI 300

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           RLPGHEFT LL +NRR+GIT+DDSVWAKIQAL
Sbjct: 301 RLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL 332


>UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinobacillus
           pleuropneumoniae RepID=A3N2M1_ACTP2
          Length = 235

 Score =  388 bits (997), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 178/235 (75%), Positives = 210/235 (89%)

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           +ELA+ +GIG+VALRNANHWMRGGSYGWQAAEKGYIGICWTN++AVMPPWGAKE RIGTN
Sbjct: 1   MELASQNGIGVVALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKEYRIGTN 60

Query: 158 PLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR 217
           PLIVA+P+TPITMVDMS SM+SYGMLEV+RLAGRQ  VD GFDD+GN T++P  +EKNRR
Sbjct: 61  PLIVAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDDGNPTRDPATVEKNRR 120

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTR 277
           ++PMG+WKGSG+SIVLDMIATLLS+G S A VT+D  DEY +SQ+FIAIEVD+LIDG T+
Sbjct: 121 LMPMGFWKGSGLSIVLDMIATLLSNGESTATVTEDKDDEYCVSQVFIAIEVDRLIDGKTK 180

Query: 278 DAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           D KL RIMDYV +AERAD   A+RLPGHEFT +LA+N+ NGI VDD+VWAK+Q+L
Sbjct: 181 DEKLNRIMDYVRTAERADPEVAVRLPGHEFTQILADNKANGIPVDDTVWAKLQSL 235


>UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemophilus influenzae
           22.1-21 RepID=A4MVY7_HAEIN
          Length = 234

 Score =  356 bits (914), Expect = 6e-97,   Method: Compositional matrix adjust.
 Identities = 156/215 (72%), Positives = 189/215 (87%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V++++LK  F RVL+ R +  E A+ CA  F  TT++G YSHG+NRFPRFIQQLE GD
Sbjct: 1   MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I+P+A P ++ SLG+IEQWDA ++IGNLTAKKMMDRAIELA+ HG+G++ALRNANHWMRG
Sbjct: 61  IVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTN++AVMPPWGAKECRIGTNPLI+A+P+TPITMVDMS SM+SY
Sbjct: 121 GSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           GMLEV+RLAGRQ  VD GFDDEGNLT++P ++EK 
Sbjct: 181 GMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKT 215


>UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria RepID=A9KQQ8_CLOPH
          Length = 334

 Score =  329 bits (843), Expect = 1e-88,   Method: Compositional matrix adjust.
 Identities = 157/331 (47%), Positives = 209/331 (63%), Gaps = 2/331 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ ++ +   F RVLI  G   E A   A++FA  +  GVYSHGVNRFPR I  +E G 
Sbjct: 1   MRIQYDDMVKEFTRVLIKYGFSEEKAKLSAKLFADNSLDGVYSHGVNRFPRVISYIEKGY 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+    +  + G +E+WD    +GNL A+  MDRAIEL+  HGIG +A++N NHWMRG
Sbjct: 61  IKPEQTAAKTEAFGCVERWDGNLGMGNLNAQICMDRAIELSRTHGIGCIAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G+YGWQAA  G IGICWTN++  MP WGAK+ RIG NP IVAIP  S    + D +MS F
Sbjct: 121 GAYGWQAANAGCIGICWTNTMPNMPAWGAKDRRIGNNPFIVAIPRSSGAHVVADCAMSQF 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           SYG +E  RL G++LP+ GG+D+   +T +P  IEK  RILPMGYWKGSG+SI  D+IAT
Sbjct: 181 SYGKVEEYRLNGKKLPIPGGYDENDEITNDPAAIEKTSRILPMGYWKGSGLSIAFDLIAT 240

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           +LS G SV E+ +   DE+ ISQ+ IAI+     D    D  +  ++D + ++    EN 
Sbjct: 241 VLSGGNSVTEIGKLGEDEFAISQVMIAIDPSHFNDVALTDELINNVLDDIKASVPVKENG 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +I  PG        EN  +GI V + +W KI
Sbjct: 301 SIYYPGESSLNTRIENTEHGIPVQEEIWEKI 331


>UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID=B7VQB6_VIBSL
          Length = 333

 Score =  314 bits (804), Expect = 3e-84,   Method: Compositional matrix adjust.
 Identities = 152/331 (45%), Positives = 221/331 (66%), Gaps = 2/331 (0%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V+ E+L+  + R+L++R +  E A   A  F      G YSHG+NRFP FI Q++ G I 
Sbjct: 4   VSTEKLQQEYERILLARDMKPEMATKLAAGFVEMANEGTYSHGINRFPVFIDQVDKGQIK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            +A+P+ + S+GA+EQWD     G L      +RA+ELA D+GIG+V +RN+NHWMRGG+
Sbjct: 64  LNAEPECVNSMGALEQWDCNYGPGVLNGLICAERAMELARDYGIGMVGMRNSNHWMRGGA 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM 182
           Y  + A +G+ GI  TNSIAVMP WG K+ R+G+NPLI+A+   P  +VD SMS FSYG 
Sbjct: 124 YVLKMAREGFAGIASTNSIAVMPAWGGKDHRVGSNPLIMAVAGDPPVVVDCSMSQFSYGQ 183

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           L+   LA ++LPV GGFD+EG LTK+P V+ +N+R+LPMG+WKGS M+IVLDM+ T ++ 
Sbjct: 184 LQNFVLADKELPVVGGFDNEGELTKDPHVLWENKRLLPMGFWKGSSMAIVLDMMLTAITG 243

Query: 243 GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
           G SV  +T+D   E+G+SQ  IAI++ K +D  T   +++RI DYV  +E A E  ++ +
Sbjct: 244 GHSVPALTEDMGGEFGVSQFLIAIDLSKTMDQSTYAQEMKRIRDYVLESEPA-ETGSVMI 302

Query: 303 PGHEFTTLLAENR-RNGITVDDSVWAKIQAL 332
            G E    + ++    GI ++D +W +I +L
Sbjct: 303 AGSEIENFIKKHEAAGGIEINDGIWEQITSL 333


>UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteria
           RepID=A8RPZ9_9CLOT
          Length = 339

 Score =  308 bits (788), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 151/341 (44%), Positives = 215/341 (63%), Gaps = 14/341 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++TF+++K+   RVL+  G+  E A+ CA +   TT  GVYSHG NR  RF+  ++ G 
Sbjct: 4   MRLTFDEIKSEIKRVLVKYGMSEEKAETCARIHTETTYDGVYSHGTNRVARFVNYIQKGW 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P      GA+  ++     G L A    DRA+ELA  +GIG+V +RN  HWMRG
Sbjct: 64  VDVNAEPSLEREFGALRVYNGNMGPGVLNALYCADRAMELADQYGIGMVGIRNTTHWMRG 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST----PITMVDMSMS 176
           G+YG  AA KGY  I WTN+ + MPPWG +ECR+G NP ++A+PS     P+ + DM+MS
Sbjct: 124 GTYGLYAARKGYAAIMWTNTESCMPPWGGRECRLGNNPFVMAVPSADGGEPLQL-DMAMS 182

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
            +SYG L+V RLAG +LP  GGFDDEGNLT +PG IE++RR+LP+GYWKGS  S +LD++
Sbjct: 183 QYSYGKLQVTRLAGEKLPYPGGFDDEGNLTDDPGAIEQSRRVLPVGYWKGSAFSFMLDIL 242

Query: 237 ATLLSDGASVAEVTQDNSDEY-GISQIFIAIEVDKLIDGPTRDAKLQRIMD----YVTSA 291
            ++L+DG   A + Q       G SQ+ I ++  +     T DA ++ I+D    YV S+
Sbjct: 243 GSVLTDGIGAAGMDQKGYGSCGGCSQVMIVVDPGRT----TTDAHMKEIVDTAVLYVKSS 298

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             ++E  ++R PG        E+ R GI VDD VW +IQ+L
Sbjct: 299 APSEEGGSVRAPGQGSARFHEEHDRLGIYVDDDVWKEIQSL 339


>UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Acidobacterium
           capsulatum ATCC 51196 RepID=C1F8E3_ACIC5
          Length = 334

 Score =  293 bits (750), Expect = 6e-78,   Method: Compositional matrix adjust.
 Identities = 148/333 (44%), Positives = 205/333 (61%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ F+ L  AF   L   G   E A+ CA +FA TT  GVYSHG NRFPRF+  + NG 
Sbjct: 2   LRIPFDDLHRAFIAALTHVGFTPERAELCARLFAETTLDGVYSHGANRFPRFLAMIRNGA 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+ +++ GA+E+WD +R  GNL A   M+RA+ L+  HGIG +ALRN NHWMRG
Sbjct: 62  VDVHATPQCMSAFGALERWDGRRGPGNLNAHAAMERALALSRTHGIGCLALRNTNHWMRG 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           GSYGWQAA  G I +CWTN++  +P WG +E  +G NPLIVA+P     +V DM+MS FS
Sbjct: 122 GSYGWQAANAGSIALCWTNTMPNLPAWGTREASVGNNPLIVAVPRRAGHLVLDMAMSQFS 181

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE        LP+ GGFD  G LT +P  IE ++R LP+GYWKGSG++++LD +A +
Sbjct: 182 YGALESYSRRSELLPIPGGFDASGTLTNDPAAIEASQRPLPIGYWKGSGLALLLDAVAAM 241

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
            + G +  ++ +D   E G+SQ+FIAI    L      +     I+  + +A   D  + 
Sbjct: 242 TALGNATHQLARDPLQETGLSQMFIAIHPAALDAAADANHLADEIVASLHAAAPVDPGRP 301

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            R PG +   L  EN R GI V+D +W +I A+
Sbjct: 302 ARYPGEQTLRLREENLRLGIPVEDVIWQQILAV 334


>UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CWH3_9CLOT
          Length = 337

 Score =  287 bits (734), Expect = 4e-76,   Method: Compositional matrix adjust.
 Identities = 139/333 (41%), Positives = 211/333 (63%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ FE++KA   +VL  RG   + A+  A   AR +  GVY+HG+NRF R I+ ++ G 
Sbjct: 4   VRLPFEEVKACLCQVLAGRGCPEKKAEKVAHEMARNSLEGVYTHGINRFARLIRNIDEGI 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P+    +GA+EQ D    +G   A   M+ A++LA  +GIGLVALRN NHWMR 
Sbjct: 64  VRPGAEPEVTVRMGAMEQVDGHLGLGITNAWFSMEEAVKLAKSYGIGLVALRNTNHWMRA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
            +YG+QA + G   +C+TN++  MP WGA + RIG NPL+ A P     ++ DM+MS FS
Sbjct: 124 ATYGYQACDAGMAAVCFTNTMPNMPTWGAVDSRIGNNPLVFAFPRREGHLITDMAMSQFS 183

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE+ RL GRQ+ +D GFD  GNLT++P  + K++RILP GYWKG+ +S +LD+ A +
Sbjct: 184 YGALELARLQGRQMAIDAGFDTAGNLTRDPDSVIKSQRILPTGYWKGAALSFMLDIFAGV 243

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LSDG +V+ V + + DE+G+SQ+FIA++   L+     +  ++  +  + ++ +A     
Sbjct: 244 LSDGNTVSGVGRLSGDEHGVSQVFIAVDYRNLVTQEAAERIVEGAVKDLLASGKAQGTDR 303

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I   G       A+N +NGI VD+ VW +I +L
Sbjct: 304 IIYTGQLTLECRADNLKNGIPVDEGVWNEISSL 336


>UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C6XSR8_PEDHD
          Length = 327

 Score =  284 bits (726), Expect = 3e-75,   Method: Compositional matrix adjust.
 Identities = 145/331 (43%), Positives = 208/331 (62%), Gaps = 7/331 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ F++LKA F RVL+      ETAD+CA +FA  +  GVYSHG+NRFP F++ ++ G 
Sbjct: 1   MRIPFQELKAEFKRVLLKLSFPPETADSCALVFAANSRDGVYSHGLNRFPVFVKLVQKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P  +   GAIE+WD   + G   A   M RA+ELA  +GIG VA++N NHWMRG
Sbjct: 61  IKANALPALLERNGAIERWDGNFAPGMSNASHCMARAVELAKINGIGCVAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G+YGWQAA+ G IGIC+TN+ A MP WG K+  +G NPL++AIP     +V DM+MS FS
Sbjct: 121 GTYGWQAADAGCIGICFTNATANMPAWGGKDPVLGNNPLVIAIPRKEGHVVLDMAMSQFS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG ++   L    LP  GG+D++GNL+ +P VI K +  LP+G+WKGSG+S+VLD++A  
Sbjct: 181 YGKMQEYELKNEALPFPGGYDEQGNLSTDPAVIRKTKLALPIGFWKGSGLSLVLDLLAVA 240

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LS G S  +++   +DE G+SQ FIAI    +      DA +  ++ Y  ++E       
Sbjct: 241 LSGGNSTGKISAQ-ADETGVSQCFIAIRQPDM-----HDALIAEVLAYTKNSEAVKAGGQ 294

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  PG        EN   GI V++ +W +++
Sbjct: 295 VSYPGERTLQTRLENEEKGIPVNEEIWMQVK 325


>UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococcus prevotii DSM
           20548 RepID=C7RGK9_ANAPD
          Length = 337

 Score =  275 bits (703), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 136/334 (40%), Positives = 207/334 (61%), Gaps = 2/334 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVT+++LK      L + GV  E ++  A++ A +T  GV SHG+NR PR I  +  G 
Sbjct: 1   MKVTYDKLKNTIKNALKASGVSEEKSELMAKVHAESTLKGVNSHGLNRIPRLIDFINKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+ + + S G++E ++     G + A K  DRA ELA +HGIG+V LRN  HWMRG
Sbjct: 61  VDINAEMELVKSFGSVENYEGNLGFGVINALKASDRAAELAKEHGIGMVTLRNTTHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G+Y    A+KG IG+CWTN+ ++MP WG+ E  +G NP+ ++IPS    + +DM++S++S
Sbjct: 121 GAYSENIADKGMIGMCWTNTESLMPVWGSDEISLGNNPIGISIPSESGNICLDMAISLYS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE  RL G +LP  GGFD  GNLT +P +IE+++ +LP+GYWKGSG+ I LD +A L
Sbjct: 181 YGKLETTRLKGEKLPYPGGFDKGGNLTDDPKLIEESQNLLPVGYWKGSGLGICLDTMAAL 240

Query: 240 LSDGASVAEV-TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           LS+G S  ++  +D  +    SQIFIA+  +        +  +++I + V SA   +   
Sbjct: 241 LSNGLSTYDMDDRDGFNCTSCSQIFIAMNPEAFSTKEENEKTIRKIKERVKSAHPTNPGL 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + R PG    T   +  R GI +DD ++ K+++L
Sbjct: 301 SPRYPGLGLYTRKEKGLREGIEIDDKIFKKVESL 334


>UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C5EL83_9FIRM
          Length = 349

 Score =  255 bits (651), Expect = 2e-66,   Method: Compositional matrix adjust.
 Identities = 131/335 (39%), Positives = 201/335 (60%), Gaps = 4/335 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ ++ +K    +  ++ G+  E A+ CA +  +++  GV SHG+NR PRF++ ++ G 
Sbjct: 3   LRIPYDTIKETVKKAFLNVGLSEEQAEVCATIHTQSSADGVESHGLNRIPRFVEYVQKGW 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  + +P+   + GA+E +D    IG   A    DRA+ELA +HGIG V L+N  HWMRG
Sbjct: 63  INLEGKPELAGARGAVENYDGHLGIGITNALFCADRAMELAKEHGIGCVTLKNTTHWMRG 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
           G+Y W+ AE G++GI W N+ + MP WG+ E  +G NP  +AIP    PI + DM+MS +
Sbjct: 123 GTYAWRMAEAGFMGISWINTESCMPLWGSDEPGVGNNPFCIAIPREDGPIVL-DMAMSQY 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           +YG L V RLAG++LP  GGFD +GNLT +PG IE+++RILP GYWKGSGM+I LD+ A 
Sbjct: 182 AYGKLGVYRLAGKELPFPGGFDKDGNLTSDPGAIEESKRILPTGYWKGSGMAIALDLAAA 241

Query: 239 LLSDGASVAEVTQDNSDEY-GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LL++G    ++ + N     G  Q+FIA +           + L R +    ++    E 
Sbjct: 242 LLANGNCGTDMDEANQGSCTGCCQVFIAFDPYLFGSKDEIQSMLNRRVAAADASHPEREG 301

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  PG    +  A +   G+ VD+ VW ++QA+
Sbjct: 302 SHVTCPGERTVSTRARSMAEGVNVDELVWEQVQAI 336


>UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogenase n=1 Tax=Clostridium
           sp. M62/1 RepID=UPI0001C34ECB
          Length = 379

 Score =  141 bits (355), Expect = 4e-32,   Method: Compositional matrix adjust.
 Identities = 98/332 (29%), Positives = 167/332 (50%), Gaps = 15/332 (4%)

Query: 11  AFNRVLISR-GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKR 69
           +F R L  + G++   A   AE   +T   G+ SHG  R P + +++ NG I      ++
Sbjct: 38  SFVRELFEKAGMERGDAQFHAEALVQTDLWGISSHGCMRVPAYFERMRNGAINVRPNVRK 97

Query: 70  ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAE 129
           ++  GA E  DA    G +  K+ M+RA+ELA  + I  V +RN+NH+  G  Y   AA+
Sbjct: 98  VSGEGAFEVLDADAGAGFIAGKRAMERAMELAKKYHIAAVGVRNSNHFGAGAVYARMAAK 157

Query: 130 KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGMLEVN 186
           +G  GI  TN + ++   GA     G NP+ VAIP+    P  + DM++S  + G L + 
Sbjct: 158 EGMAGIAMTNVLPLVTAPGASRPVTGNNPIAVAIPTYGDFPFCL-DMALSKVAGGKLTLA 216

Query: 187 RLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA-- 244
              G ++P+D   D+EG  T +P    K   +LP+G +KG G++ V+D+++ +++ G   
Sbjct: 217 IKRGEKIPMDWATDEEGRPTDDPEKAFKG-FLLPVGGYKGLGLAYVVDILSGVVTGGVFS 275

Query: 245 -SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA---DENQAI 300
             +  +    ++       F+A+++D +ID   R+   QR+ +Y    +     +E   +
Sbjct: 276 HQMKSMYAQPTEPSLTGHFFVAVDIDAVID---REQMKQRMGEYFRRIKETPMWEEGAEM 332

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            LPG        E R NGI V    + ++  L
Sbjct: 333 LLPGELEYRKEKERRENGIPVPVKTYEELLEL 364


>UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5
          Length = 369

 Score =  140 bits (353), Expect = 6e-32,   Method: Compositional matrix adjust.
 Identities = 96/348 (27%), Positives = 165/348 (47%), Gaps = 20/348 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV +E LK   + V    G   E +    ++   +   G+ SHG+ R  ++  +++NG I
Sbjct: 5   KVKYEGLKKLCDIVFEKFGFSPEDSGTITDVLLLSDLFGIESHGIQRLVKYYSEIKNGLI 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D++PK I         DAQ  +G L  +K M+ AIE A   G+G+V +RN+NH+   G
Sbjct: 65  KVDSKPKIIKETPVSAILDAQAGMGQLAGRKAMNMAIEKAKTSGMGMVVVRNSNHYGIAG 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT-MVDMSMSMFSY 180
            Y   A E+G +GI  TNS AV+ P   K+  +GTNP+ +++P+ P   ++D++ S+ + 
Sbjct: 125 YYAKMAEEEGLLGISMTNSPAVIIPTFGKDAMLGTNPIAISMPAKPYPFLMDIATSVVTR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILP----------------MGYW 224
           G +EV       LP+    D  G  T++P  I  N   LP                 G  
Sbjct: 185 GKIEVYNKRHEPLPLGLALDKNGEDTEDPYDILYN---LPKKLGGGLVPLGGSKELTGGH 241

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           KG G+++ +++   +LS G +   VT   S   G    F A++     D  + + KL   
Sbjct: 242 KGYGLALAVEIFTAILSGGITGNYVTLQGSSGSGTCHYFCAVDYSIFGDKNSIEDKLSEY 301

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ + ++++A     I   G +      +   NGI +++    +I  +
Sbjct: 302 LNELRNSKKAKGALRIYTHGEKEIESYKDKMENGIPMNEVTLKEIDEI 349


>UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TYB0_METKA
          Length = 341

 Score =  138 bits (348), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 86/295 (29%), Positives = 152/295 (51%), Gaps = 5/295 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  E L    +  L + GV  + A   AE+       G +SHGV R P +I+ ++ G 
Sbjct: 1   MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGA 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ + + I+   ++  +DA  S+G++   +    A+ELA  HG+G+VA+RNA+H+   
Sbjct: 61  IRPEMRIEEISRKSSVVLYDADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
           G Y    AE+G+IG     +   + P+G  +  +GTNP+ +A P    P  +VDM+ S+ 
Sbjct: 121 GYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVSIAFPRRDGPPIVVDMATSVV 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +       R++P D     +G  T +P    +   +LP G  KG  + + L+++A 
Sbjct: 181 ARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEG-ALLPFGGHKGYALCLALEVLAG 239

Query: 239 LLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
            +   A+  +V  T D +       +F+A+++  L+D      +L+R++  V SA
Sbjct: 240 PVVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSA 294


>UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. GAI101
           RepID=B7RGK0_9RHOB
          Length = 361

 Score =  137 bits (346), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 98/339 (28%), Positives = 161/339 (47%), Gaps = 13/339 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L A    +LI  G   + A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MKISAEHLTALATSILIHAGGQPDAAQRIATRLVSANLTGHDSHGVGMIPAYVDGIFAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PDA    +   G     D QR  G++ A++ MD AI+ A  +   +++LRN+ H  R 
Sbjct: 61  LDPDASVDVVQDKGPFLLVDGQRGFGHIVAEQAMDLAIQRARTNHFAVLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G +G  AAE G+I I + N   S  ++ P+G  + R  TNP   AIP+T   P+ ++DM+
Sbjct: 121 GDWGAMAAEAGFICILYANVQSSRPLVAPFGGSDGRFVTNPYCTAIPATDTHPMFLLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  + G   V  L+G+Q+P     D +GN T +P V+  +    +   G  KG G++++
Sbjct: 181 TSKIAMGKARVAHLSGKQVPEGSLIDAQGNPTTDPSVMFDDAGGALTTFGDHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTR--DAKLQRIMDYVTS 290
            D++    S G +      +      I+   +AI +D  + G  +     + R  D+V +
Sbjct: 241 GDILGGSFSGGGA---YLPEREVPLSITNNMLAILIDPDVFGMAQAFGVDMDRYTDWVKA 297

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +  A    A++LPG        + + NGI VD    A +
Sbjct: 298 SPPAPGVDAVQLPGDPERRSAQDRQANGIFVDAGTRAHL 336


>UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=C6DD67_PECCP
          Length = 362

 Score =  136 bits (342), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 93/336 (27%), Positives = 161/336 (47%), Gaps = 12/336 (3%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           T   L+      L    VD+  A   A+    ++  G  SHGV+  PR+I  +  G + P
Sbjct: 27  THHYLRDYLRDRLTENDVDASIAGTVADNLVESSLKGHDSHGVSMLPRYIDAIREGGLSP 86

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            AQ ++    G +  +D Q+  G + AK+ +   I  A  HG+ +V+L NA+H  R G++
Sbjct: 87  HAQAEKTLDFGPLISFDGQQGFGQVVAKQALTEGIARAQTHGLVVVSLANAHHLGRIGAW 146

Query: 124 GWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
             QAAE G + + + N  +  V+ PW  ++ R GTNP    IP     P+ ++D + S+ 
Sbjct: 147 AEQAAEAGLVSLHFANVYTKPVVLPWQGQQARFGTNPFCAGIPVEHDDPV-ILDFATSVI 205

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYWKGSGMSIVLDMI 236
           +     +    G+ +      D+EGN T +P  + +     +LP G  KGSG+S+V  ++
Sbjct: 206 AGNKARIAWNEGKSVAPGCIVDNEGNPTVDPRWLMEQPLGALLPFGEHKGSGLSLVCSLL 265

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
              L+ G       +    +   S + I I+  KL    T   ++  ++++V  +   D+
Sbjct: 266 GAALT-GGKTERTAKGEGKQIINSMLSILIDPQKLGGAATYQQEIPALLEWVRQSR--DD 322

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           N+ + LPG +      + + NGI VDD  W ++  L
Sbjct: 323 NELL-LPGDKEKQTYRQRQENGIFVDDVSWGQLSYL 357


>UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bacteria
           RepID=C3MH59_RHISN
          Length = 358

 Score =  135 bits (341), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 88/330 (26%), Positives = 158/330 (47%), Gaps = 8/330 (2%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           ++L A   ++  + G+    A   A    +    G+ SHGV+R P ++++L+ G + P  
Sbjct: 10  DELIAFATKIFAATGMADADAATIAGDLVKANLRGIDSHGVSRIPMYVERLQRGLVNPKP 69

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
                   GA+   D    +G + + +  + AIELA  +GIGLV +  + H+  G  Y  
Sbjct: 70  AVTVKKVAGAVSLVDGDNGMGFIASHRATEEAIELARANGIGLVGVHRSTHFGMGALYAL 129

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGM 182
           QA E GYI + +TNS   +P WG +   +G +P+   IP     P  M DM+M++ + G 
Sbjct: 130 QAIEAGYISMIFTNSSPAIPMWGGRTTFLGASPIAAGIPGGKYAPYVM-DMAMTVIARGK 188

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           + +  + G  +      D +GN T +     +    LP G  KGS ++ ++D+++ +L+ 
Sbjct: 189 IRLAAMKGETIAEGLALDVDGNPTTDAAKAFEG-VCLPFGGVKGSVLATLMDLMSGVLTG 247

Query: 243 ---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
              G  V  +  D+S+   +  +F AI+ D  +     DA++    + + +  +A   + 
Sbjct: 248 ANFGGDVKSLYFDHSEPQNVGHLFFAIKPDLFMSPENFDARMDAFYERIKALPKAAGVEE 307

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           I +PG       AE  R GI +  +V A +
Sbjct: 308 IMMPGEPEQRREAERLRTGIPITANVIADL 337


>UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriaceae
           RepID=B7UPM1_ECO27
          Length = 357

 Score =  135 bits (340), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 94/338 (27%), Positives = 162/338 (47%), Gaps = 18/338 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+++     +L   G D++ A   AE        G  SHGV   P++++ +  GD
Sbjct: 3   LQIAVEKVRWLAAGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGD 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P+ +TS G ++++ A    G    K  ++ AIE     G  L+ L +A+H  R 
Sbjct: 63  VTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQTKHRGFCLLTLCHAHHLGRM 122

Query: 121 GSYGWQAAEKGYIGICWTNSI---AVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G YG   A++G   +  +N     A++ PWG  E R+ TNP   A P +   P  +VD +
Sbjct: 123 GHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFA 182

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYWKGSGMSIV 232
            S  +     V    G+Q       D +GN + +PGV+  N    +LP G  KG G++++
Sbjct: 183 TSSMALNKARVMSSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALM 242

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIF-IAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++M+A +LS G ++AE  Q +   +  + +F + I+ D+  D      K Q   DY+ + 
Sbjct: 243 IEMMAGILSGGDTIAEDHQTDGSAH--NHLFALIIDPDQFTD--LAGEKGQFFADYLLAT 298

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNG--ITVDDSVWA 327
           +       +  PG       A   RN   IT+  S W+
Sbjct: 299 QPQPGGNPVIYPG---MPEAANRERNAKMITIPVSFWS 333


>UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01XF2_SOLUE
          Length = 344

 Score =  134 bits (338), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 86/333 (25%), Positives = 169/333 (50%), Gaps = 12/333 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + L      +L   GV    A+        +   GV SHG+   P +I QL  G++ 
Sbjct: 4   ISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMD 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+ + I+  G+   +D Q ++G   A+     A+ +A ++G+ LV  R +NH+   G+
Sbjct: 64  AQAEGRVISESGSCLHFDGQNALGQWVAENCCKHAVRIARENGMALVVARESNHF---GA 120

Query: 123 YGWQAAE---KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFS 179
             W A +    G IGI   N+  ++PPW  +E R+GTNP+ +++P     ++DM+ +  +
Sbjct: 121 AAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPICMSVPGP--WLLDMATTTVA 178

Query: 180 YGMLEVNRLAGR-QLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            G +    L  + ++P    FD +G  T +     K   ++P+G +KGSG++++++++ +
Sbjct: 179 AGKIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKG-MLMPLGGYKGSGLAMMVEILCS 237

Query: 239 LLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +LS GA   EV   +       +SQ+++AI+V + +      A++++++  + S + A  
Sbjct: 238 VLSGGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPG 297

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              + + G     + AE R NGI +    W ++
Sbjct: 298 YTEVMVAGDPEWRMEAERRENGIPIAGGNWDQL 330


>UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TYW6_9PROT
          Length = 352

 Score =  134 bits (338), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 15/341 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +  E+L     R++   G D   A+  A    +    G  SHGV   PR+++    G 
Sbjct: 1   MIIGHERLTGIVTRMIQGAGSDLAEAETVATNLVQANLMGHDSHGVGLAPRYMKHARAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +P  IT  G     D     G    ++  + AI  A + G  +V LR  +H  R 
Sbjct: 61  MNLGVRPSVITDNGVYLLLDGNMGYGQTVCREATEMAIARAKEKGAAIVGLRRTHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMP---PWGAKECRIGTNPLIVAIPS---TPITMVDMS 174
           G++G   AE G I I + N+    P   P+G  E R  TNP   AIP+   TP+ ++DM+
Sbjct: 121 GAWGEMCAEAGLISIHYVNTTGHRPYVAPYGGFEARYSTNPYCTAIPATDKTPMIVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  + G + V   AG++ P D     +G  T +P VI  E    +L  G  KG G++++
Sbjct: 181 TSRVAQGKVRVAYYAGKKTPADALVGPDGLPTDDPKVIFEEPYGAMLSFGQHKGYGLAMI 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKL---IDGPTRDAKLQRIMDYVT 289
            +++A  L+ G +  E   D +    I    + I +D      D P R +++ +++++V+
Sbjct: 241 CEILAAGLTGGGTAREELMDQNT---ICNNMLMIVIDPKGFGADIPFR-SEIDQLVEHVS 296

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           S++ A     +R PG      +AE    GI +DD+ W +++
Sbjct: 297 SSKTAVGFDKVRFPGDPEREAMAERAAKGIWIDDNTWGEMR 337


>UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XHB0_MEIRU
          Length = 336

 Score =  134 bits (337), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 89/325 (27%), Positives = 158/325 (48%), Gaps = 6/325 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  +QL+    ++LI+RG   E A   AE        GV SHG+ R P ++++   G + 
Sbjct: 4   IPVQQLRERVEQILINRGFTLENALPIAESLVLAEMRGVASHGLIRLPIYLERARLGSVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+P  +    A+   DAQ   G  +  K M+ AIE A   G+  V +R ++H+     
Sbjct: 64  PQARPVLLADYPALALLDAQDGHGIPSGLKAMELAIEKAQKVGLAAVGVRRSSHFGLAWY 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           +   A EKG +G+  +N+ A++ PWGA+   +GTNPL V IP+   P   +DM+ S  ++
Sbjct: 124 FVRSAVEKGLVGVALSNADALVAPWGARSRFLGTNPLAVGIPAMEEPPIALDMATSEAAH 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + + +G+ +P++   D EG  T +P        +LP G  KGS +S+++D++   L
Sbjct: 184 GKILLAKSSGKTIPLNWALDAEGRPTDDPDRALAG-ALLPFGGPKGSAISLLIDVLCGPL 242

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                G  +A +  +     G+   F+A+      D      ++   +  V +   A+  
Sbjct: 243 VGALIGPEIAPLYTEPERPQGLGHFFMALNPGVFGDAEQFRKQVDAYIRRVRALPPAENV 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVD 322
             + LPG     L  +  + G+++ 
Sbjct: 303 DRVLLPGEREWRLEQKALQEGVSLS 327


>UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=D0KCK6_PECWW
          Length = 355

 Score =  134 bits (336), Expect = 6e-30,   Method: Compositional matrix adjust.
 Identities = 96/340 (28%), Positives = 152/340 (44%), Gaps = 14/340 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++  +L A    VL   G +   A    E        G  SHG    P +++ +  G 
Sbjct: 1   MQISANRLMATVQVVLQKAGCEENEARIVTEHLVAANLKGHDSHGAGMLPHYVEFIGKGI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+   R  G  T K+ M  AIE     G+ L+ L +  H  R 
Sbjct: 61  MHPNTPARLLRDSGAVLQFTGDRGFGQRTGKEAMQAAIERVKTTGVCLMTLSSTCHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMP---PWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G+YG  AA+ G + I + N   + P   PW   E R GTNP+ +A P T      ++D +
Sbjct: 121 GTYGEMAADAGLVSIHFVNVNDLEPIVAPWCGSEARFGTNPICIAFPPTEHNAAFVLDFA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI---EKNRRILPMGYWKGSGMSI 231
            S+ + G   V  LAG+    +   D  G  T +P V+   EK+  + P+   KG G+ +
Sbjct: 181 TSVVALGKTRVAYLAGKTFDEEVMLDCNGVSTNDPKVMWEGEKHGALKPIAKHKGGGLIL 240

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVD--KLIDGPTRDAKLQRIMDYVT 289
             +M+A LLS G +   +  +N  +  I      I +D   ++       +   ++DYV 
Sbjct: 241 AAEMLAGLLSGGGT---IQPENVRQGAIVNNMTTIVIDPTSMVSMAWLQKEYDAMLDYVR 297

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           S+   D  Q I + G       A+ R +GI V D  W KI
Sbjct: 298 SSTAPDPTQPILIAGEPERLSQAQRRADGIYVSDQEWQKI 337


>UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C320A5
          Length = 360

 Score =  131 bits (329), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 86/298 (28%), Positives = 148/298 (49%), Gaps = 9/298 (3%)

Query: 40  GVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE 99
           G+ SHG    P +++++  G +    +P  +  LGA+   DA  ++G ++A   M  AIE
Sbjct: 44  GIPSHGSLLVPMYVERIVKGSVATATEPATVADLGAVAVLDAGHALGVISADTAMALAIE 103

Query: 100 LAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL 159
            A  HG+G VA+R+A H+     Y   AA+ G +G+   N+  +MP  G     +G NPL
Sbjct: 104 KARAHGLGAVAVRHAFHFGGAFRYVQAAADAGMVGVAAANTRPLMPAPGGAHAVVGNNPL 163

Query: 160 IVAIPST---PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR 216
            V +P     P+ + DM++S  + G + +    GR +P     D +G  T +P V     
Sbjct: 164 AVGVPRAGGEPLVL-DMALSEAALGKIRLAAQEGRAIPATWATDADGAPTTDP-VAAIAG 221

Query: 217 RILPMGYWKGSGMSIVLDMIATLLSDGA---SVAEVTQDNSDEYGISQIFIAIEVDKLI- 272
            +LP    KG G+++++D++  +LS GA   SV  +  D       +  F+A++V +   
Sbjct: 222 LLLPAAGHKGYGLALIVDVLTGVLSGGAFGRSVNGLYADTGVPNDCAHFFLALDVARFAG 281

Query: 273 DGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           D  T  A++  +   VTS   A   + + +PG       A  R  G+ +D +V A+++
Sbjct: 282 DLDTFSARVAELSAQVTSPPTAPGVERLLVPGQLEAERHAAAREQGVALDATVLARLR 339


>UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococcales
           RepID=COMC_METJA
          Length = 344

 Score =  128 bits (322), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 96/323 (29%), Positives = 159/323 (49%), Gaps = 11/323 (3%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           VL   GV  E A   A++F      G  SHG+ RFP++I  L+ G+I P    K +    
Sbjct: 15  VLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVKESP 74

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           A    D    +G +  KK M+ AI+ A + G+G+VA RNANH+   G Y   A  +  IG
Sbjct: 75  ATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIAGYYSELAMNQDMIG 134

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYG-MLEVNRLAGRQ 192
           I  TN+   M P+G KE  +GTNP+ +A         +DM+ +  + G +LE  R    +
Sbjct: 135 ITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALR-KKIK 193

Query: 193 LPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVA---EV 249
           +P     D +G  T +P    +   ILP G  KG G+++ ++M++ +   GA V    + 
Sbjct: 194 IPEGCAVDKDGKPTTDPAKALEG-CILPFGGPKGYGLALAIEMLSAI--GGAEVGTKVKG 250

Query: 250 TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTT 309
           T +  +      +FIAI  +  +       K+  ++D + ++E A E   I +PG E   
Sbjct: 251 TANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPA-EGFEILIPG-EIEE 308

Query: 310 LLAENRRNGITVDDSVWAKIQAL 332
                R++G  +D +++ +++ +
Sbjct: 309 RNKMKRKDGFEIDKNLYNQLKEI 331


>UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FVL5_DESHD
          Length = 351

 Score =  128 bits (321), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 87/325 (26%), Positives = 163/325 (50%), Gaps = 10/325 (3%)

Query: 14  RVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSL 73
           R+L + GV +  A   + +   T+  G+ +HG++R P +++ L  G I P  +PK   ++
Sbjct: 16  RLLEASGVPATDAGIVSSILVDTSLEGIDTHGISRLPVYLKCLLKGRINP--KPKIQETI 73

Query: 74  -GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGY 132
             A+ + D    +G L A + M+ AI+LA  +GIG   ++N+NH+    +Y   AA +  
Sbjct: 74  DAAVARVDGDNGLGQLVAYRAMNSAIDLAKIYGIGFATVKNSNHFGAASTYCKLAAAQQM 133

Query: 133 IGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAG 190
           IG  +TNS + +PPWG +    GTNP+    P    P+ +VDMS S  + G + +    G
Sbjct: 134 IGQAYTNSPSGIPPWGGRAPYFGTNPISYGFPHAEYPV-VVDMSSSTVARGNIILAAKNG 192

Query: 191 RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD---GASVA 247
            ++P     D +G  T       +   +LP+G  KG  +++  +++A ++S    G+ V 
Sbjct: 193 EEIPEGWAMDKDGKATTNAKAALEG-AVLPIGGAKGYTLALAAEVMAGIISGSAYGSHVG 251

Query: 248 EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEF 307
            +  +  +   I   F+AI + KL+       ++  ++  V +  +A+    IR+PG   
Sbjct: 252 WIYDEGREPVNIGHSFLAINIAKLMPVEEFSQRMGDMIREVKAIPKAEGITEIRIPGERR 311

Query: 308 TTLLAENRRNGITVDDSVWAKIQAL 332
                + +++GI V + +  ++  L
Sbjct: 312 QANAEQRKQDGIPVAEGLLQELNML 336


>UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RKJ3_9CLOT
          Length = 349

 Score =  127 bits (320), Expect = 4e-28,   Method: Compositional matrix adjust.
 Identities = 93/329 (28%), Positives = 156/329 (47%), Gaps = 9/329 (2%)

Query: 11  AFNRVLISR-GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKR 69
           AF + L  + G+    A   AE    T   G+ SHGV R P + +++ NG I  + Q K 
Sbjct: 8   AFTQELFQKAGMSEPDAKYHAECLVNTNYWGIDSHGVIRVPAYFKRMLNGAINTNPQIKV 67

Query: 70  ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAE 129
           +   G +E  D   + G +  +  M+RA++ AA  GI    + N+NH+  G  Y   AAE
Sbjct: 68  VRGEGCLEVLDVDAAAGFIGGRAGMERAMDHAAVSGIAACGVINSNHFGAGALYARMAAE 127

Query: 130 KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGMLEVN 186
           +G IGI  TN   ++   GA     G NP+   IP+    P  + DMS+S+ + G L + 
Sbjct: 128 RGMIGIAMTNVKPLIVAPGASVPVTGNNPIAFGIPTYGEFPFVL-DMSLSVVAGGKLTLA 186

Query: 187 RLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA-- 244
                ++P+D   D  G  T +P     +  +LPMG  KG G+S V+D+++ L++ G   
Sbjct: 187 IKKKEKIPMDWATDKNGRPTDDPQA-AFDGYLLPMGGHKGLGLSYVVDILSGLITGGVFS 245

Query: 245 -SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLP 303
             +  +  +  D       FIA+++ K+I       ++ +  D + +     E   + LP
Sbjct: 246 KDMKSMYANPKDPSLTGHFFIAMDISKIISKEQMKERMAQFKDQLKATPMWQEGAQMLLP 305

Query: 304 GHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           G        E R+NG+ +  + + ++  L
Sbjct: 306 GEIEYRKEQERRQNGLPIPVTTYEELAEL 334


>UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobiales
           RepID=C6B553_RHILS
          Length = 344

 Score =  127 bits (320), Expect = 4e-28,   Method: Compositional matrix adjust.
 Identities = 90/317 (28%), Positives = 146/317 (46%), Gaps = 7/317 (2%)

Query: 19  RGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQ 78
            G   + A   A +       G  SHG+ R PR ++++E G I P  +  +     A+ +
Sbjct: 19  HGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIEAGVIDPQTKGTQRWRADAVLE 78

Query: 79  WDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWT 138
            +    +G + A   ++R      D GIGLVA+RNANH      Y    A  G++GI  +
Sbjct: 79  VEGASGLGPVVAMAAIERLSPHIPDLGIGLVAVRNANHLGMLAHYVEAIAAMGFVGIALS 138

Query: 139 NSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLAGRQLPVDG 197
           +S A++ P+G     +GTNP+ +A+P+    +V D++ S+   G +  +   GR +P   
Sbjct: 139 SSEALVHPFGGTRAMLGTNPIAIAVPTAEEPLVLDLATSLVPMGSIHHHAATGRPIPEGW 198

Query: 198 GFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEV--TQDNSD 255
             D  GN T +PG   K   I P G  KG G+ I ++++   L+  A   +   T D+  
Sbjct: 199 ARDAAGNPTTDPGR-AKAGAIAPFGDAKGYGLGIAMELLVAALAGSALAPDARGTLDSQS 257

Query: 256 EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENR 315
                 +FI IE       P   A+L   +D V ++  A   + + +PG       A   
Sbjct: 258 PCNKGDVFILIEPSL---APGLPARLSTYLDAVRASPPASAGKPVLVPGDRARRRRAAAS 314

Query: 316 RNGITVDDSVWAKIQAL 332
           RNG  +D  +W  + AL
Sbjct: 315 RNGFEIDQRLWEDLNAL 331


>UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PC96_9FIRM
          Length = 353

 Score =  126 bits (317), Expect = 8e-28,   Method: Compositional matrix adjust.
 Identities = 97/341 (28%), Positives = 153/341 (44%), Gaps = 15/341 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E LKA     L   G++S  A  CAE  A T   G +SHG      +I++   G + 
Sbjct: 5   IALEDLKAFCTAALEHEGMESGDARRCAEALAETDAYGTHSHGTKNLHNYIKKFRAGGMD 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A  K +T   A    DAQ  +G   + + M+ AIE A   G+ LV +  +NH+   G 
Sbjct: 65  IHAALKVLTDGPAYALLDAQNGMGECASYRAMELAIEKARKSGVALVTVCRSNHFGAAGF 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           Y   AA+ G +G+C +N    M   GAK   +G NPL  A P  STP   +D++MS  + 
Sbjct: 125 YANMAAKAGMLGLCVSNVDPNMTAPGAKGMLLGNNPLAYAAPAKSTPSIFLDIAMSNVAS 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +   R  GRQ+P     D +G  T +P    +   + PM   KG G+SI++D++   L
Sbjct: 185 LKVVQARKDGRQIPDSWIVDKDGLPTTDPSHYPEEGAMQPMAAHKGYGLSILVDLLTGAL 244

Query: 241 SDGAS---------VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++ A+           E+ + N+    +S  F+ +  +          + +++   +  A
Sbjct: 245 ANAATSMSGEIVSWCFELDKPNN----VSHAFLVVNPEMFGGAQAYVQQNEQMAAALRKA 300

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +A  +  I  PG       A     GI + D V   I+AL
Sbjct: 301 PKAQGSTRIYTPGEIEWERYARAVSEGIKLPDDVAGSIEAL 341


>UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobium sp. NGR234
           RepID=C3MH43_RHISN
          Length = 351

 Score =  126 bits (317), Expect = 9e-28,   Method: Compositional matrix adjust.
 Identities = 93/319 (29%), Positives = 154/319 (48%), Gaps = 11/319 (3%)

Query: 2   KVTFEQLKAAFNRVLI-SRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +V  + +  AF+  L+ + G  ++ A   AE+       G  SHGV R PR+I+  E G 
Sbjct: 8   RVIAKDILEAFSAALLEAGGFRADYARQSAELLVWANLRGADSHGVLRIPRYIEMAELGI 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA+P+     GA+   D  R  G        DRA+ELAA  GIGL ++   +H    
Sbjct: 68  VKGDAKPELAREFGAVAVIDGDRVPGATGMAMAADRAVELAAKFGIGLCSILRTSHAGAV 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS----TPITMVDMSMS 176
           G +  + A  G +G+  T S  +M   G+K   + TNP+ +A PS     PI + DMS +
Sbjct: 128 GFFTERVARAGMVGVAMTASKPLMIYHGSKAEGVSTNPISIAAPSRNAARPIVL-DMSTA 186

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             + G +   + AG+ +P D G D  G  T +P ++   + +LPM   KGSG+S++++++
Sbjct: 187 AVALGKIMAAKDAGKSIPPDWGVDANGVATTDPAIV---KAVLPMAGPKGSGLSLMIEIL 243

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            ++L     ++    D  D  G + + +A+           + ++ R+   +     A  
Sbjct: 244 VSVLGGNPLISAALTDKRDA-GFNGLVLALSPTAFGPRDQLEGEIDRLSHAIKGLPPALA 302

Query: 297 NQAIRLPGHEFTTLLAENR 315
              + LPG E   LLAE R
Sbjct: 303 TDDVLLPG-ERGFLLAEKR 320


>UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobutylicum
           RepID=Q97LJ4_CLOAB
          Length = 369

 Score =  125 bits (315), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 91/344 (26%), Positives = 159/344 (46%), Gaps = 14/344 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E L      V    G   E +    E+       G+ SHGV R   + + + NG I
Sbjct: 12  KYKYEGLLNLCLEVFQRLGYTKEDSYTIGEVLLLADLFGIESHGVQRLTLYYKGIRNGSI 71

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                   +         D    +G + +KK M+RAI+ A   GIG+  ++N+NH+   G
Sbjct: 72  KVKNHMNIVKESPVSVVIDGDGGMGQIISKKAMERAIDKAKKTGIGMAIVKNSNHFGIAG 131

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT-MVDMSMSMFSY 180
            Y   A  KG +GI  TN+ A++ P   +E  +GTNP+ +A+P+ PI  ++DM+ S+ + 
Sbjct: 132 YYSRMAERKGLMGIAMTNTRAIVLPTYGREQMLGTNPISIAMPARPIPFLLDMATSVITR 191

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK-----NRRILPM-------GYWKGSG 228
           G +EV     ++L      DDEG  T  P  + K        +LP+       G  KG G
Sbjct: 192 GKVEVYSKNNQKLNYGWAMDDEGRKTDNPDKVLKLANGNTGGLLPLGGDTEIFGGHKGYG 251

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +S  ++M  ++LS G +  E+ + N++  G+   F AI+     D    + ++   M  +
Sbjct: 252 ISFAVEMFTSILSGGLTSDEI-RGNNNTNGVCHAFAAIDYGLFDDKNAIEKRMSAYMQKI 310

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            ++++A     I   G +      +   NGI ++++   +I+ +
Sbjct: 311 RNSKKAYGASRIYTHGEKELEAYEDRMENGIPINENTIVEIKEI 354


>UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp. CCS1
           RepID=Q28JS2_JANSC
          Length = 362

 Score =  125 bits (313), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 92/331 (27%), Positives = 155/331 (46%), Gaps = 6/331 (1%)

Query: 6   EQLKAAFNRVLISRGVDSETAD--ACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           EQL+        + G+  E A   A A +F+          GV R  R+ +++ NG++ P
Sbjct: 13  EQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNGEVNP 72

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            A    +    A+   DA   IG + A K M  AI+ A + GIG V +RN+ H+     +
Sbjct: 73  RAGWSIVKEGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGSSAVH 132

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYG 181
             QA E G IG+ +TN+   M PWG +E   GTNP  +A PS     T++D++++    G
Sbjct: 133 ACQALEHGCIGVAFTNAGPEMAPWGGREGVTGTNPWSIAAPSDQGFPTVLDIAITTAGKG 192

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
           M+      G+++P+D     +G+ T +P    K   +L +G  KG G++ + + +  +LS
Sbjct: 193 MMNWLIREGKKMPLDWAITPDGDETDDPAAALKG-PLLGIGGHKGYGLAFMTEALTGVLS 251

Query: 242 DGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
            G         +  +  +S  F AI+++  +D      ++   +    +         I 
Sbjct: 252 -GGGFGLTPYSDPQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGFDEIL 310

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +PG +     A    NG+ +DD V A +QAL
Sbjct: 311 VPGEQEARRTAAKAENGVPIDDVVLADMQAL 341


>UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LTF1_SYNAS
          Length = 373

 Score =  125 bits (313), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 86/352 (24%), Positives = 164/352 (46%), Gaps = 21/352 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V  ++L     ++  S GV  E A  CA+        G+ SHGV R  R++  + NG 
Sbjct: 13  LYVNNQKLTQFVQKIFSSFGVTREDAVICADNLVLADLRGIPSHGVARLRRYVDGMSNGT 72

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I+P ++P  +    +    D Q  +G +        AIE A   G+G+VA+RN+NH+   
Sbjct: 73  ILPHSKPIIVREAPSTATVDGQAGLGQIVGHFSTQLAIEKARKTGVGIVAVRNSNHYGIA 132

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
           G Y     + G +GI  TN+  ++ P   ++  IGTNP+ +  P+    P   +DM+ S+
Sbjct: 133 GYYTQMMLDAGLLGISMTNTAPLVVPTFGRKMIIGTNPISMTAPTRRNKPF-FLDMATSV 191

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGYW 224
              G LEV    G+ +P     D +G    +   + +N                   G +
Sbjct: 192 IPRGKLEVYDRMGKDMPEGWAVDSKGQTATDATEVLRNMVARLGGGILPLGGEGELYGGY 251

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYG----ISQIFIAIEVDKLIDGPTRDAK 280
           KG G+++++D++  +LS GA    V        G    ++  F+A+ ++  ++      K
Sbjct: 252 KGYGIALLVDILCGVLSGGAYADLVDIKGPGGAGQPALVAHFFMALNIENFVEMEIFMEK 311

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  ++D +  + +A+    I + G +   L  ++R+ G+ ++++V   ++A+
Sbjct: 312 MDDLIDRLKESAKAEGQNRIYIHGEKEYELYEQHRQTGVPLEENVHETLKAI 363


>UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaproteobacteria
           RepID=A8I2I9_AZOC5
          Length = 350

 Score =  125 bits (313), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 96/336 (28%), Positives = 159/336 (47%), Gaps = 10/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E L A    +L + G     A   A++     + GV SHGV R PR+++ +  G 
Sbjct: 6   LTLAPEALSAFAAGLLEAGGFRPADAKKSADLLVWANQRGVDSHGVLRIPRYVEMVGLGL 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+PK +   GA+   DA  + G    +++ D+AIE+A   G G    RN  H    
Sbjct: 66  INPAAEPKVVNEWGAVALIDAGLAPGASAMEQVTDKAIEIAGRLGGGFCVGRNVTHAGAV 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS----TPITMVDMSMS 176
           G +  + A +G +GI  T S  +M   GA+   + +NPL +A PS     PI + DMS +
Sbjct: 126 GYFAHRIAARGLVGIVMTASKPLMAYPGARGEVVSSNPLAIAAPSEVAGEPIVL-DMSTA 184

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             + G +   R AGR +P   G D  G  T +P  ++    + PM   KG+G+S++++++
Sbjct: 185 AVALGQVLAARDAGRTIPEGWGIDAAGRPTTDPAAVQA---LTPMAGAKGAGLSLMIEVL 241

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            +LL+    +A      +   G +    AI+             ++ +   +     A+ 
Sbjct: 242 CSLLAGNPLIAPAL-SGAAPAGFNGFVAAIDPGAFGSRERFLGDVRGLAAAIHGLPPAEG 300

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            QA+ LPG E     AE RR+GI +     +K++ L
Sbjct: 301 TQAVLLPG-ERGRRTAETRRSGIPLARGTSSKLKEL 335


>UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGX7_KOSOT
          Length = 352

 Score =  124 bits (312), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 92/351 (26%), Positives = 163/351 (46%), Gaps = 26/351 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV  E+L      V+   G D E A   AE+       G+ SHGV R  R++  ++   
Sbjct: 1   MKVKREKLMNFTADVMKKMGCDDEKARVVAEVLVEADMRGISSHGVARLKRYVNHIKERI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ +P+ I         D    +G   AK  M++ IE A  +GIG+  +RN+NH+   
Sbjct: 61  IDPNGEPEIIFETPVTLAIDGNNGVGQHIAKFSMEKVIEKAKKYGIGMATVRNSNHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSM 177
           G Y   A + G +GI  TN+  ++    ++E  +GTNP+  A P++   PI ++DM+ S+
Sbjct: 121 GYYAEMAVKMGLVGISLTNTAPLVVHTFSREALLGTNPIAFAFPTSEKYPI-LIDMATSV 179

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR-------------ILPMGYW 224
              G LEV     +++P     D+ G+ T +P  +  N +                    
Sbjct: 180 APRGKLEVYSRLNKKIPKGWAVDETGHTTTDPEKVLSNLKQRKGGGLLPLGGEGEEFSGH 239

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYG-ISQIFIAIEVDKLIDGPTRDAKLQ- 282
           KG G+ ++++    LL+ G S+   + D     G I+  F A+  D  I G     K   
Sbjct: 240 KGYGLVLLVE----LLTSGLSLGSFSYDTYKGKGKITHFFAAL--DPAIFGNPEKIKEHA 293

Query: 283 -RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +++ + SA++AD  + I + G +      ++   G+ +D+  + +++ +
Sbjct: 294 MELINSLRSAKKADGKERIYVHGEKEYEKREKSLECGVEIDEPTYYELRKI 344


>UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=A2R6I4_ASPNC
          Length = 362

 Score =  124 bits (312), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 84/310 (27%), Positives = 147/310 (47%), Gaps = 7/310 (2%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           +L+  G+ +E A + AE        GV +HG+ R P+++ ++ NG + P           
Sbjct: 23  LLVKAGLMAEDARSMAECLVLADVRGVDTHGLARLPQYLDRVSNGRVNPRPSINITQKTP 82

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
            +   D     G + A + MD AI+ A  +GIG+V + ++NH+    +Y  QA +   I 
Sbjct: 83  VVAHLDGDNGFGFVVATRGMDEAIKRAEIYGIGMVTVNHSNHFGMAATYVLQALKANMIS 142

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT--MVDMSMSMFSYGMLEVNRLAGRQ 192
           + +TNS   MPP+G KE  +G +P     PS      ++DM+ S+ + G +      G  
Sbjct: 143 LVFTNSAKQMPPFGGKETLLGISPFAAGAPSNTEVPYILDMAPSVVAKGKIRRAARRGES 202

Query: 193 LPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD---GASVAEV 249
           +P+    D +GN T +  V   N  + P+G  KGSG++I++D+++ +L+    G  V + 
Sbjct: 203 IPLGWALDADGNPTTDANV-ALNGSMAPIGGPKGSGIAILMDIMSGVLAGAEFGGQVGDQ 261

Query: 250 TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTT 309
            +D   +  +   FIAI+ D ++      A++  +   V     A     +  PG     
Sbjct: 262 YKDTKPQ-NVGHCFIAIKPDIIMSTDDFKARMDILAQRVHGVSPAPGFSEVLFPGEPEHR 320

Query: 310 LLAENRRNGI 319
           L  + R  GI
Sbjct: 321 LGLQRRAEGI 330


>UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_PYRAB
          Length = 362

 Score =  124 bits (312), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 89/341 (26%), Positives = 158/341 (46%), Gaps = 10/341 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  ++L +   RVL   G   E A   A+        G+ SHGV R  R++  + +G 
Sbjct: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    + K I    +    D     G +   K M  AIE A   GIG+VA+RN+NH+   
Sbjct: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y   AAE+G IGI  TNS  ++ P G  E  +GTNP+ +A P+   P  ++DM+ S+ 
Sbjct: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPF-LLDMATSVV 190

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI-------EKNRRILPMGYWKGSGMSI 231
             G LEV R  G ++P     + +G +T+    +               +G  KG G+S+
Sbjct: 191 PIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSL 250

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++D+++ +LS G     V   N     +   F+AI ++          ++  +++ + ++
Sbjct: 251 MVDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNS 310

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  + + I + G +    +    + GI +   V  ++  +
Sbjct: 311 RKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEI 351


>UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2BFJ4_9BACI
          Length = 364

 Score =  124 bits (312), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 88/337 (26%), Positives = 163/337 (48%), Gaps = 8/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E+L+   + V I  GV  E A+  AE   +    G+ SHGV R   +I+++E   +
Sbjct: 6   KFDWEKLQKFCSDVFIKAGVKREDAETVAESLIQADLRGIDSHGVVRTDIYIKRIEKNMM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A+        A    +    +G +   K +D A+  A + G  +V ++ +NH+  G 
Sbjct: 66  NPFAEISIEEETDATALVNGHNQLGAIVGSKALDLALHKAKEKGAAIVGVKGSNHFGTGA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
            Y  +A EK  I +  +N+   MPP G     IGTNPL + +P+      ++DM+ S+ +
Sbjct: 126 FYVSKAIEKDMILLVLSNASQTMPPTGGVRPFIGTNPLAIGVPAGEEEAFILDMATSVVA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGN-LTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            G + V    G  +P+    D  GN  T     +E +  +LP+G  KG G+S+ +D++A 
Sbjct: 186 RGKIIVAAQKGEDIPLGWAIDKHGNPTTNAQDALEGS--VLPLGGPKGYGISMFIDILAG 243

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L+    G  V  + ++ +D   +   F+AI+++  +   T   ++   +  + +  RA 
Sbjct: 244 VLTGAGFGRYVNNMYENWNDPQNVGHFFLAIDINSFMPIETFKKRIDMYLREIKAEPRAI 303

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               I +PG   +  + E ++NGI +   V  +++ +
Sbjct: 304 GVDKIYIPGEIESFKVKERKKNGIELPSKVVEELRLI 340


>UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoanaerobacter
           ethanolicus CCSD1 RepID=C7IP78_THEET
          Length = 349

 Score =  124 bits (311), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 96/342 (28%), Positives = 160/342 (46%), Gaps = 19/342 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE----- 57
           V  ++LK     +    G     A   AE    +   G+ SHG++  P ++++ +     
Sbjct: 5   VDAKKLKELEVEIFKKAGFKESDAKIIAENLIYSDLRGIESHGISNLPIYVKRAKLGLYN 64

Query: 58  -NGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANH 116
            +GDI      K I  L      D + ++G + A K ++  +  A   GI    + N NH
Sbjct: 65  LSGDIDILNLDKDIPLL----LIDGKNNMGQVAAYKAVEPLVNKAKKSGIAAAFIGNTNH 120

Query: 117 WMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSM 175
               G YG   A    I I  TN+ A M PWG K   +GTNPL + IP +  +  +DM+ 
Sbjct: 121 CGSLGYYGNMIANNDCIFIGMTNAPASMAPWGGKVKFVGTNPLCITIPYNGQVINLDMAT 180

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           S  + G + V    G ++P +  FD  G  T +P    K   + P+G +KG G+++++D+
Sbjct: 181 STVAKGKIYVALSKGDKIPDNWAFDANGKPTTDPQEALKG-TLYPLGGYKGFGLAMLIDI 239

Query: 236 IATLLSDGASVAEV-----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           I+ LL+  +   EV     T D   + GI  +FIAI +  L+     + K+   ++ + S
Sbjct: 240 ISGLLTGSSWGPEVGSLHNTLDRGQDVGI--VFIAINITDLMPIKEYNEKINCYIEKMKS 297

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             R+D+N  I  PG      + E  +NGI ++D  + ++  L
Sbjct: 298 VPRSDDNSEIMFPGEPELRKMEERLKNGIPINDKTYEEVIEL 339


>UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesenteroides ATCC 33313
           RepID=C5RAQ8_WEIPA
          Length = 363

 Score =  123 bits (309), Expect = 8e-27,   Method: Compositional matrix adjust.
 Identities = 101/358 (28%), Positives = 167/358 (46%), Gaps = 47/358 (13%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           +++ A  N++  + G   E +   A+    T   G+ SHGV R   + + ++NG I  D+
Sbjct: 8   QKMNALVNKIYQAYGFSKENSQKIADALIYTDLHGITSHGVQRLALYDRFIQNGKIRIDS 67

Query: 66  QPK--RITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            P+  + T + A+   DA    G L     M  AIE A  HG+G+V  + + H+   G Y
Sbjct: 68  HPEIEKETDVSAV--IDANFGSGQLNGMYSMGVAIEKAKAHGVGIVTTKRSGHYGIAGYY 125

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGM 182
              AAE+G IG+   NS   M P  AK+  IGTNP+  A+P+ P   + D + ++   G 
Sbjct: 126 ANLAAEQGLIGMSSCNSRPGMIPTNAKKAFIGTNPIAFAMPAKPHNFIFDAATTVVPQGK 185

Query: 183 LEVNRLAGRQLP--------------------VDGGFDDEGNLTKEP--GVIEKNRRILP 220
           +EV R   + LP                    +D   D E N+   P  G+ E+      
Sbjct: 186 IEVYRKQEKDLPALWVAKEGNQPVYDHTDTATLDSLRDPEANVGIAPLGGITEET----- 240

Query: 221 MGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAI------EVDKLIDG 274
            G  KG G+ I++++  ++LS G + AE++  +  E G  Q FIAI      + +K+ID 
Sbjct: 241 -GGHKGYGLGIMVEVFTSILSLGNTSAEISASDV-ETGPCQSFIAIDPAIFGDSEKIIDK 298

Query: 275 PTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +R  +  R +  V   E       + + G +      + ++NGI +DD    +I+A+
Sbjct: 299 FSRYLEDLRQLTAVPGKE-------VYVHGDKEQLAYQDRKKNGIEIDDKTIMEIKAI 349


>UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TKN7_9PROT
          Length = 361

 Score =  123 bits (309), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 86/327 (26%), Positives = 151/327 (46%), Gaps = 7/327 (2%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L+    RV  + G+    A   A+        G++SHGV R P ++++L    + P   P
Sbjct: 18  LRDTVARVFAACGMTDGDAVTLADSLVHADRRGIHSHGVLRVPDYVKKLTEDGVDPRGHP 77

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
           + ++  GA    D   ++G +     +D  I+ A    +   A+R +NH      Y  + 
Sbjct: 78  RIVSDAGAALVIDGGNAMGQIAGTLAVDAVIDRARSVNVAFAAVRGSNHSGALDWYTMRI 137

Query: 128 AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLE 184
           A +G IGI  +N++  M PWG  +  +G NP+ +A+P     PI + D+++   ++G + 
Sbjct: 138 AAQGMIGIAGSNALPTMAPWGGVDKIVGLNPISIAVPGGEHGPIVL-DVALGATAHGKIR 196

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           V     +Q+P    FD  G  T +      +  I P+G  KG G+++++ ++A++LS   
Sbjct: 197 VYAQKDQQIPEGWAFDASGVPTTDAAA-ALDGLIQPIGGHKGIGLALMVGLLASVLSGAG 255

Query: 245 SVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
              E     D +      Q ++AI V    D     A + R+      + RAD  + + L
Sbjct: 256 YGTESGNMVDGATPGADGQFYLAINVAAFRDIADFTAHISRVARQYRDSRRADGVERLYL 315

Query: 303 PGHEFTTLLAENRRNGITVDDSVWAKI 329
           PG     +   NRR+GI ++D   A I
Sbjct: 316 PGDLEAEVAERNRRDGIPLNDEAVALI 342


>UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclobacillus
           acidocaldarius RepID=C8WTM6_ALIAD
          Length = 353

 Score =  123 bits (308), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 98/325 (30%), Positives = 155/325 (47%), Gaps = 20/325 (6%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP--KRITSLGAIE 77
           GV    AD  A     +   G+ SHGV R P ++  L++G + P+ +   +R   + A+ 
Sbjct: 22  GVAKRDADWSATALVESDLRGISSHGVMRLPWYLHGLKSGKVNPNPRLVWRRTGPVTAV- 80

Query: 78  QWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICW 137
             DA  ++G ++AK+    A+ELA + G+G VA+R ANH      Y   A   G +G C 
Sbjct: 81  -LDADDALGFVSAKEAAAHAVELAREAGLGAVAVRRANHCGALFLYAEWATLYGMVGFCC 139

Query: 138 TNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM---VDMSMSMFSYGMLEVNRLAGRQLP 194
            N+   + P G ++  IGTNP+  A P TP+     +D+S S  S G +      G  LP
Sbjct: 140 ANTHPALAPPGGRKPVIGTNPIAFAAP-TPLDYPLSIDLSTSAISRGAVIERARRGESLP 198

Query: 195 VDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAE----VT 250
                D++G  TKEP        +LP+G  KG  ++++++++A +L+ GA VA     + 
Sbjct: 199 DGVAVDEDGAPTKEPHRALSG-ALLPIGGAKGYALALMVEVLAGVLA-GAQVAGDVGFMF 256

Query: 251 QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA---IRLPGHEF 307
            D+    G    ++A+  D  +    ++A LQR+   V     A   Q    I +PG   
Sbjct: 257 ADDGKPPGNGFFYLALHPDFFVG---QEAFLQRMASLVAEIHDAPSAQGQPPISVPGERR 313

Query: 308 TTLLAENRRNGITVDDSVWAKIQAL 332
                   R GI + D VWA +  L
Sbjct: 314 HRERVSRSRRGIPISDEVWADLAEL 338


>UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=Amycolatopsis
           orientalis RepID=Q9XBD3_AMYOR
          Length = 337

 Score =  122 bits (306), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 86/335 (25%), Positives = 151/335 (45%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L+A   R+L++ G  +  A+  A     +   G  SHGV R   +++++  G 
Sbjct: 1   MNVQAAELEALATRILVAAGSSTVDAETVARSLVGSDLLGHDSHGVRRVIDYVKRIHTGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+PK  T+         +R+ G L  ++ +   + L    G G+  +R  NH  R 
Sbjct: 61  IDPRAEPKAETTRPGTVVVHGRRAFGQLAVRRAVRELLSLVPHQGSGVAVVRECNHIGRL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI---PSTPITMVDMSMSM 177
           G Y    A++  IG+ + N+   + P+G +E R+GTNPL  A+   P  P  ++D + S 
Sbjct: 121 GEYVAMLADQDLIGLAFGNADPTVAPYGGRERRLGTNPLAWAVPRGPGQPPIVMDWATSG 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G L V R  G Q+      D  G  +  P    +   +LP G  KG G+S++++++ 
Sbjct: 181 IAEGKLRVARDRGEQVAEGLVLDAAGRPSTTPADFYQGGALLPFGGHKGYGLSVLIEIVG 240

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L     S   +        G   + +A ++   +  P   A+ +R    +     A+  
Sbjct: 241 GL----LSGIGIGSMPGFREGWGTVLVAFDIAAFLPVPEFRAQTERFCQALAETPLAEGA 296

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +PG     +  E  R+GI V  + W ++ AL
Sbjct: 297 SEVLVPGEPEERIRLERARDGIPVTANTWRELNAL 331


>UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonocardineae
           RepID=A4FEK8_SACEN
          Length = 375

 Score =  122 bits (306), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 96/354 (27%), Positives = 161/354 (45%), Gaps = 32/354 (9%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V +  L +   R+   RGV ++ A   A        +G+ +HG+    R ++   ++G
Sbjct: 15  VRVDYADLLSFTTRLFAERGVPADRAHTAASALCYGDLTGLEAHGLFNLTRLYLPLFDSG 74

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            + P AQP+ +T LGA    D++R++G  +A + MD A + AA HGIGLV +R+A H+  
Sbjct: 75  RVDPAAQPRVLTDLGACAVVDSRRALGLWSAAEAMDSAADRAAQHGIGLVTVRDATHFGC 134

Query: 120 GGSYGWQAAEKGYIGI----CWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDM 173
            G +  +AAE+G IG+    C    IA  P  G     +GTNPL VA P+ P    ++DM
Sbjct: 135 AGFHTARAAERGVIGVLAGNCGGQRIARPP--GGTPAMLGTNPLSVAAPALPGHPFVLDM 192

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL-------PMGYWKG 226
           S ++   G +      G  +P     D  G    +P   ++    L         G +KG
Sbjct: 193 STTVVPTGRVRTAAARGEPVPPGWLVDSSGAAVTDPAAFDRGEAYLNWLGGDQDTGAYKG 252

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQ---------DNSDEYGISQIFIAIEVDKLIDGPTR 277
            G+ +V++++  LL  GA +    +            D+ G S I IA  + +    P R
Sbjct: 253 FGLGLVVELLGALLP-GAGLGPAPEALDGDGRPHGRDDDIGFSAIAIAPRLLR----PDR 307

Query: 278 D--AKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           D     + + + + +   A  +  +R PG           R G+ V   + A +
Sbjct: 308 DFAGAARALFETINACPPAPGHADVRYPGWWEAERAQSRLREGVPVPAGLHADL 361


>UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangium ochraceum DSM
           14365 RepID=D0LLD6_HALO1
          Length = 355

 Score =  122 bits (305), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 75/268 (27%), Positives = 136/268 (50%), Gaps = 11/268 (4%)

Query: 13  NRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITS 72
            +VL+  G+    A + A     T+  GV +HG+   P ++++LE G      Q +   +
Sbjct: 18  TQVLVRNGLSESDARSVANGLVETSLRGVDTHGLRLLPLYVKELEGGRSNARPQFRFEAT 77

Query: 73  LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGY 132
             ++ + DA  ++G +      D+A+E+A   G+G+V++ N+NH+     YG + A +G+
Sbjct: 78  RASVVKMDADAALGIMAGFAGADKAVEVARKSGVGVVSVANSNHFGAAALYGLRIARQGF 137

Query: 133 IGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLA 189
           IGI  T++ A + P+G +    GT+P+    P     P  + DM+ S  SY  ++ +RL 
Sbjct: 138 IGIALTHAAARVAPFGGRTQLFGTDPICFTAPRKDGHPFCL-DMATSQISYSKVKHHRLR 196

Query: 190 GRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEV 249
           G  L      DD G  T EP  +     + P+G +KG G+S+++ ++  LL+D     E+
Sbjct: 197 GETLEPGWAVDDHGEPTVEPDSVSA---LSPVGGYKGQGLSMMVQVLCALLADMPLDWEL 253

Query: 250 TQDNSDEYG----ISQIFIAIEVDKLID 273
           +  +S  +     IS  F+AI+     +
Sbjct: 254 SHLDSGGFSEPRKISHFFMAIDFSAFTN 281


>UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EMJ6_OCEIH
          Length = 356

 Score =  121 bits (303), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 88/320 (27%), Positives = 153/320 (47%), Gaps = 9/320 (2%)

Query: 12  FNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT 71
           F R L+ + +  E A+  AE        GV SHGV R   +++++E+G I        + 
Sbjct: 14  FCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGIIERKTDISVVQ 73

Query: 72  SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKG 131
              A    DA    G +   K M+ AI+ A  +G   V + N+NH+     Y   AAEKG
Sbjct: 74  DSFATALLDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTASFYTRMAAEKG 133

Query: 132 YIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS----TPITMVDMSMSMFSYGMLEVNR 187
           +IGI  TN+  +M P+GAKE  +G NP+ ++IP+     PI ++DMS S  + G + V +
Sbjct: 134 FIGISMTNASPIMVPFGAKEPSLGPNPISISIPAGEGKKPI-ILDMSTSNVARGKIMVAK 192

Query: 188 LAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVA 247
                +P       +G  T +     +   +LPMG  KGSG++I++D+++ +L+      
Sbjct: 193 KNKESIPEGWAITKDGKQTTDADEAWEG-FVLPMG-PKGSGLAIIIDILSGVLTGSLFGK 250

Query: 248 EVTQDNSDEY--GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGH 305
            + +   D Y   +  +F AI ++   +       +   ++   S+E ++    + +PG 
Sbjct: 251 RIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSEGFDQVYMPGD 310

Query: 306 EFTTLLAENRRNGITVDDSV 325
             +    E + NGI +   +
Sbjct: 311 MESQRKKEYKENGIPLSQEI 330


>UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B6HAQ0_PENCW
          Length = 357

 Score =  120 bits (300), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 85/322 (26%), Positives = 150/322 (46%), Gaps = 15/322 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +    L+    ++LI+     E A+  ++        GV +HG NR P +++++    + 
Sbjct: 14  INHTDLQNFVKQILIANKTSPEHAEIVSKCLVSADLRGVDTHGSNRIPSYMERIRQNALD 73

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A P       A+ Q DA    G + A + M  AI +A   GIG+V+++++NH+   G 
Sbjct: 74  PSAVPTIRQVTPAVAQVDAHNGFGFVAAHEGMKLAISMAQIFGIGMVSVKHSNHF---GM 130

Query: 123 YGW---QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMS 176
             W   QA E   + + +TNS   +P WG KE  +G +P+    P+    P  ++DM+ S
Sbjct: 131 SAWLVQQALEADMMSLVFTNSSPALPVWGGKEKLMGVSPIACGAPAGEGRPF-ILDMAPS 189

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
           + + G +      G ++P D   D +G  T +P    +   +LPMG  KGS +S+++D+ 
Sbjct: 190 IAARGKIYKALRRGEKIPTDWALDKDGAGTDDPAEALQG-VMLPMGGPKGSALSVMMDVF 248

Query: 237 ATLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           + +LS  A    VT   D S    +    +AI+ D  +       ++  +   V  +E+ 
Sbjct: 249 SGVLSGSAFAGHVTNPYDPSKPADVGHFLVAIKPDLFMTIEEFKGRMDYLYQRVVDSEKM 308

Query: 295 DENQAIRLPGHEFTTLLAENRR 316
                I  PG     ++ E +R
Sbjct: 309 AGVDRIYFPGE--IEMITEEKR 328


>UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SD16_9ACTO
          Length = 732

 Score =  120 bits (300), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 90/345 (26%), Positives = 156/345 (45%), Gaps = 13/345 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V  + L+     VL + GV    A   A + A    SG+ SHG+ R P ++  + NG 
Sbjct: 374 VRVPADVLETWTAEVLEAVGVRPSHARDTARVLAYADLSGIDSHGIARLPAYVGAIGNGV 433

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D +P   +   A+   D    +G+       D A+  A  +G+G V +R ++H    
Sbjct: 434 IAVDGRPSVHSDGSAVALVDGHDLLGHPVTTFAFDEAVARARRYGVGWVNVRRSSHHGAS 493

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLI--VAIPSTPITMVDMSMSMF 178
           G Y + AA  G +G+  TN+  V+ P GA    +GTNPL   V +P     + DM+ S  
Sbjct: 494 GCYVYDAARLGLVGLAATNTGPVVAPAGAARPYLGTNPLALGVPVPGEEPLVFDMATSAV 553

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR-RILPMG------YWKGSGMSI 231
           + G  E+    G+ +P+  G D EG  T +P  +   R  +LP+G        KG G+ +
Sbjct: 554 AAGKFEIALRLGKPVPLGWGVDAEGRPTTDPAAVFPGRGALLPLGSDRERSSHKGYGLGL 613

Query: 232 VLDMIATLLSDGAS---VAEVT-QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           +++++  +L+ G +   V  +T +  +     S + + ++  +L D         R++  
Sbjct: 614 LVELLTAVLAGGPTGPGVGNLTFRSGARSPDTSHLVVVLDPARLGDPEAIGGGAARLLAE 673

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +      D +  +R PG       A  R  G+ +D      +QAL
Sbjct: 674 LRGLAPVDPDLPVRTPGQRAAAERALRRELGVPLDAETHRALQAL 718


>UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomycetaceae
           RepID=D2R8T1_9PLAN
          Length = 351

 Score =  119 bits (298), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 86/325 (26%), Positives = 148/325 (45%), Gaps = 14/325 (4%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           +L++ G   E A   +         G  SHGV R P ++  +++G+++P A+ K +    
Sbjct: 16  MLLAGGATPEEARITSVSLVDANLRGYESHGVMRIPYYLDAIQSGEVVPAAELKILDQGA 75

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           A    D Q   G + A ++ +    LA   G+ +  +  + H  R G Y   AA +G + 
Sbjct: 76  ARVVADGQWGFGQVQAVRLFELLAPLAQQEGLAVGTMIQSGHIGRLGEYNEMAAARGLVS 135

Query: 135 ICWTNS----IAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLA 189
           I   NS    + V PP G K  R+ TNPL + +P     +V D S S  + G + V ++A
Sbjct: 136 ILMVNSHGAAVRVAPP-GGKAPRLSTNPLAIGVPCGDAPLVLDFSTSATAEGKVRVKKIA 194

Query: 190 GRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMG---YWKGSGMSIVLDMIATLLSDGA 244
           G+ +P     D+EGN T +P  +  N    ILPMG    +KG G+ ++++++   LS G 
Sbjct: 195 GQAVPEGWLLDNEGNPTTDPNTLYGNPPGSILPMGGTQSYKGFGLGLMIEILTGALSGGV 254

Query: 245 SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPG 304
           +   V        G     + ++  +        A++ +++DY+ +  R +    I LPG
Sbjct: 255 TARPVPYPKK---GNCVFMMLVDPARFGGSDHFAAEVTQLVDYIRTTPRVEGCNEITLPG 311

Query: 305 HEFTTLLAENRRNGITVDDSVWAKI 329
                L A  +  G+  D   W  +
Sbjct: 312 DPERKLYAARKSTGLVFDPENWKAL 336


>UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsis dassonvillei
           subsp. dassonvillei DSM 43111 RepID=C1YJN3_NOCDA
          Length = 377

 Score =  119 bits (298), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 100/351 (28%), Positives = 160/351 (45%), Gaps = 24/351 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V  + L A    V   RG+  + A   A        +G  SHG+    R ++  L+ G
Sbjct: 16  VRVRHDDLVAFAAGVFTDRGLPPDRAAEAARALCHGDLAGPRSHGLANLTRLYLPLLDEG 75

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              P A+P+ +  LGA   WD++R++G   A + MD A E AA HGIGLV++R A H   
Sbjct: 76  RADPAAEPRVLADLGAAVLWDSRRALGLWAASEAMDLAAERAARHGIGLVSVRGATHLGC 135

Query: 120 GGSYGWQAAEKGYIGI----CWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDM 173
            G +  +AAE+G +G+    C    IA  PP GA    +GTNPL VA P+   P  ++DM
Sbjct: 136 AGYHALRAAERGMVGLVASNCGRQRIA-RPPGGAV-AMLGTNPLSVAAPAGEHPPFLLDM 193

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL-----PMGYWKGSG 228
           S +    G +      G  LP     DD G    +P   +  R  L       G +KG G
Sbjct: 194 STTAAPTGRIRQAAREGLALPEGLLCDDTGAPVTDPAAFDAGRAHLMWLGGEAGRYKGFG 253

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSD------EYGISQIFIAIEVDKLIDGPTRDAKLQ 282
           + +++++++ L+    +       + D      +  I     AI    L  G   DA+  
Sbjct: 254 LGLMVEVLSALVPGAGTGPHPDALDGDGGPSGRDDDIGFFVAAIAPGALRQGADDDAR-- 311

Query: 283 RIMDYVTSAERADENQAIRLPG-HEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +   + +    D +  +R PG HE+     E R  G+ ++  ++A++  L
Sbjct: 312 ELFGALLACPPTDPDAPVRYPGWHEYHRAR-ELRLAGVPLEAELYAELAEL 361


>UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SP37_METPP
          Length = 365

 Score =  119 bits (298), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 96/317 (30%), Positives = 152/317 (47%), Gaps = 24/317 (7%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           GV  E AD  AE+       GV SHGV   PR+++ +  G + P    + +   GA+   
Sbjct: 28  GVSPEHADQIAEVVVFADLRGVESHGVQFTPRYVRGIARGHLNPKPDIRVVHRRGAVAVV 87

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           DA   +G L+A++ M  A+ +AA+HG G VA+RN+NH+     Y   A E G IG   T+
Sbjct: 88  DADNGLGFLSARRAMKEAMAIAAEHGSGSVAVRNSNHFGPAAFYPMMALEAGMIGYATTD 147

Query: 140 SIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRLA---GRQL 193
                  WG++   +  +P+  A P+    PI +VD + +    G+ E  RLA   G  +
Sbjct: 148 GPPHTVVWGSRRPVLSNDPVGWAFPTLEGLPI-VVDTAFT----GVKEKIRLAAQRGGTI 202

Query: 194 PVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ-- 251
           P D     +GN T +P V  +   +LP+G  KGS + I  +++   L+      EV+   
Sbjct: 203 PADWAVGPDGNPTTDPKVALEG-YLLPIGQHKGSALIIANEVVCGALAGALFSFEVSPKL 261

Query: 252 ----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS---AERADENQAIRLPG 304
               D+ D +       A++     D   RDA L+R  +  ++   A RA+  Q I +PG
Sbjct: 262 VMGADHHDSWKCGHFVQALDPGAFGD---RDAFLRRTSELASALRNAPRAEGVQRIYMPG 318

Query: 305 HEFTTLLAENRRNGITV 321
                L A+  R+G+ +
Sbjct: 319 EIEAELSAQRLRDGLPL 335


>UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GVF2_9DELT
          Length = 365

 Score =  119 bits (298), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 93/337 (27%), Positives = 159/337 (47%), Gaps = 14/337 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KVT   ++    ++LI  GV  E  +   +      +SG  +HG+ R P ++++++ G +
Sbjct: 24  KVTISAVRNISKQILIHVGVSPEHTEIIVDSIVYAHQSGKGTHGLGRLPLYVKKIQAGFM 83

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             +     +     +   DA+   G + A K MD  I  A  +GIGLV +R +N++    
Sbjct: 84  AAETSTDLVKDTPVLAVMDAKNGFGQVAATKAMDLCINKANYYGIGLVGVRRSNNFGTAS 143

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST----PITMVDMSMSM 177
               QAA KG IGI   NS   + P G      GTNPL +A P+     PI++ DM+ S+
Sbjct: 144 FITEQAAAKGMIGIVLGNSGPAIAPTGGSHPLFGTNPLGIAFPNPVGEFPISL-DMATSV 202

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMGYWKGSGMSIVLDMI 236
            + G +     +  ++P     D  G  T +P   +E +  ++P+G  KG G+S+ +D++
Sbjct: 203 VARGKVRQAAKSNEKIPFGWALDGNGQPTCDPFQALEGS--MIPIGDHKGYGLSLAIDIL 260

Query: 237 ATLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           A LL+  A   +V    D S       + + I VD  +   T D   Q+I   V+S +  
Sbjct: 261 AGLLTGSAFGGDVHPLGDMSANSNYGHLCMTINVDFFM---TIDEWSQKIAYLVSSIKSC 317

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + + IR+ G E +     N +  + V + V   I++
Sbjct: 318 GDPEKIRIHG-ESSHRSIRNSKEYVLVKNRVINDIES 353


>UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CT69_9CLOT
          Length = 349

 Score =  119 bits (297), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 82/320 (25%), Positives = 148/320 (46%), Gaps = 9/320 (2%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           +KA  + +  + G +   A+  A+         VYSHG+ R   + +++ +  I  +  P
Sbjct: 1   MKAWISDIFRAEGFNGGEAELVADSLVDADARSVYSHGIQRVKLYTKRIMSDCINREGCP 60

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +    A    D   ++G    K  M+ AI+ A  +G+  V  R +NH+ R   Y   A
Sbjct: 61  VIVVDRDATAVVDGDNAMGQTVGKFCMELAIQKARQYGVSFVTARGSNHYGRCAYYTRMA 120

Query: 128 AEKGYIGICWT-NSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGML 183
            E   IG   T     +M PWG  + R+G NP   AIP+    P+ + DM+MS+ + G +
Sbjct: 121 LEYDMIGFSATIGGGNLMAPWGGTDSRVGNNPYSYAIPAFNHYPVVL-DMAMSVVAKGKV 179

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
           +V       +P     D  G  T +     K   + P+  +KGSGM+IV+ M+ +++S+G
Sbjct: 180 DVASKTHSPIPDTWALDQNGFPTTDAEEALKG-SLRPIADYKGSGMAIVIGMLCSVISNG 238

Query: 244 A---SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           A   ++  V  D        Q+F+A+++ ++ D      ++ R +D++ ++  A   + +
Sbjct: 239 AIGPTLKRVYGDFDGGLNKGQLFMAVDISRMTDVQVFKERMDRQIDFIKASPAAANTEEV 298

Query: 301 RLPGHEFTTLLAENRRNGIT 320
            LPG           ++GI 
Sbjct: 299 YLPGELEYRSFDRQMKDGIV 318


>UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836
           RepID=D2Q379_9ACTO
          Length = 362

 Score =  118 bits (296), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 88/324 (27%), Positives = 157/324 (48%), Gaps = 10/324 (3%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L+A  + V  + G +   A   A         GV SHG+   P ++++L  G +  + + 
Sbjct: 19  LEATVSSVFTALGFEPVDAGQIAHSLVEADLRGVSSHGIMLVPMYVERLNAGGVTREREL 78

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +   GA    DA+  +G L++ + M  AIE A  +GIGLV++RNA+H+     +  QA
Sbjct: 79  DVLHDAGAAIVADARGGMGQLSSPQAMGLAIERAGRYGIGLVSVRNAHHFGAASRWAVQA 138

Query: 128 AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT--MVDMSMSMFSYGMLEV 185
           A+ G +GI  +N+  +MP  G  E  +G NPL +A+P+      ++DM++S  + G + +
Sbjct: 139 ADAGCLGIAMSNTTPLMPAPGGAERVVGNNPLAIAVPTEAGAELVLDMALSAVALGKIRL 198

Query: 186 NRLAGRQLPVDGGFDDEGNLT--KEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
              AGR +P +   D  G  T   E  V+     +LP    KG G+++++D++  +LS G
Sbjct: 199 AAAAGRPIPDNWATDPSGLPTTDAEAAVLGM---LLPAAGHKGFGLALMIDVLTGVLSGG 255

Query: 244 A---SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
                V  + ++       + +F+AI+ + L        +   + + V ++  A     +
Sbjct: 256 GWGDRVRPLYREPDRPNDCAHLFLAIDPELLGGIEGFRQRSSALAERVRNSATAPGVDRL 315

Query: 301 RLPGHEFTTLLAENRRNGITVDDS 324
            LPG        + RR G+ V+ S
Sbjct: 316 YLPGEIEADRARQQRRTGVLVERS 339


>UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobacillus plantarum
           RepID=C6VL76_LACPJ
          Length = 362

 Score =  117 bits (294), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 93/332 (28%), Positives = 150/332 (45%), Gaps = 23/332 (6%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           G   E +   A M   T   G+ SHGV R   +   + NG I    +P+ +         
Sbjct: 22  GFTEEESQEVAHMLIYTDLIGIESHGVQRMIMYDDFIRNGKIRVHNRPEVVKETDVSAVV 81

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           DA   +G L     M  AIE A  HGIG+V  RN+ H+   G Y   AAE+G IG+   N
Sbjct: 82  DAHFGLGQLNGIYSMRLAIEKAKQHGIGIVTTRNSGHYGIAGYYANMAAEEGLIGLSSCN 141

Query: 140 SIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLAGRQLPV--- 195
           S + M P  A +  +GTNP+  A+P+ P T + D + +    G +EV R  G+ +P    
Sbjct: 142 SRSAMLPTHATKALVGTNPIAFAMPANPNTFIFDAATTTVPQGKIEVYRKLGKDMPALWV 201

Query: 196 --DGGFD-DEGNLTKEPGV---IEKNRRILPM-------GYWKGSGMSIVLDMIATLLSD 242
             DG    +  N TK+      ++ N  + P+       G  KG G+ +++++   +LS 
Sbjct: 202 AKDGETPVNSHNDTKDLDALRDLDSNVGLAPLGGVTEDTGSHKGFGLGVIVEVFTAILSM 261

Query: 243 GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE--NQAI 300
           G +  E+T D+    G  Q F+AI+     D   +DA + +   Y+ +         + +
Sbjct: 262 GNTSNEITPDDL-SVGPCQSFVAIDPSIFGD---KDAIIAKFSAYLQAIRDLPSVPGKPV 317

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + G +      +   NGI +DD   A++  +
Sbjct: 318 IVAGDKEAAAYQDRSANGIEIDDKTLAEVTGI 349


>UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C765_SPHTD
          Length = 355

 Score =  117 bits (294), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 90/327 (27%), Positives = 157/327 (48%), Gaps = 10/327 (3%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           VL+  G+  + A   AE+   +   G+ SHGV R   + ++L  G I      + IT   
Sbjct: 20  VLVGFGLSRDEAAITAEVLIASDIRGIDSHGVPRLGYYAERLRKGLINLTPNFRVITETP 79

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           A   +DA   +G+  A + M R IE A + G+ +  +R++NH+   G Y   A E+G  G
Sbjct: 80  ATIAFDADNGMGHPAAYRAMRRCIEKARETGLCMATVRHSNHFGIAGYYAMMALEEGLCG 139

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRLAGR 191
           +  TN+  ++ P  A+E  + T P+ VAIP+    PI +VD++ S  ++G +E+ R   +
Sbjct: 140 VAMTNATPLVIPTFAREPYLSTAPIAVAIPAGRERPI-VVDLATSTVAWGKIEIARREEK 198

Query: 192 QLPVDGGFDDEGNLTKEPG---VIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA---S 245
            +P     D EGN+T +P     +        +G  KG  +++V++++   L+  A    
Sbjct: 199 PIPWGWALDAEGNITTDPFAAVALTPLGATRELGSHKGYALALVVEVLCGQLAGAAWSRY 258

Query: 246 VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGH 305
           VA           I   F+A  +D         A++ +++  + +AE  +    + +PG 
Sbjct: 259 VAGSRTVPPRPANIGHAFMAWRIDAFRPEEEFLAEIDQMLAELRAAEPVEGQPRVYVPGD 318

Query: 306 EFTTLLAENRRNGITVDDSVWAKIQAL 332
                 A+ R NGI V   V A+++AL
Sbjct: 319 PEDLAEADRRANGIPVHPKVLAELRAL 345


>UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunction enzyme n=3
           Tax=Candidatus Pelagibacter RepID=Q1V2K0_PELUB
          Length = 336

 Score =  117 bits (292), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 84/333 (25%), Positives = 152/333 (45%), Gaps = 9/333 (2%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
            +LK     + I   ++ + A  CAE        G  SHG++R   +  ++    I P A
Sbjct: 4   SKLKTIIKDIFIKYKLNKDHATICAEALINAELVGAPSHGLSRLKMYCDRISKKVINPKA 63

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           + K      +I   D   SIG + A   +  AI  A   GIGLVA++N+ H+   G Y  
Sbjct: 64  KIKVKKISQSIAHVDGNNSIGFVAADTAIKTAINNAKKTGIGLVAVKNSGHYGLSGYYAE 123

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGM 182
           QA +KG + + +TN+   + P GA +   GTNP+    P+    P  ++D S+SM + G 
Sbjct: 124 QAVKKGLMVMVFTNAPPAVAPHGALKSLFGTNPICFGTPTGSKVPF-ILDTSISMINRGK 182

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           + V    G ++P     D  G  T +P    +  + LP+  ++GSG++ ++D+++ +L+ 
Sbjct: 183 IRVAAREGTKIPEGVALDKFGKPTTDPKKALEGVQ-LPIAGFRGSGLAWMVDILSGVLTG 241

Query: 243 GASVAEVTQDNSDEYG---ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           G     V    +D  G   I  +F  ++ + L  G + + +++  +  +    +    + 
Sbjct: 242 GNHAGRVKDPFTDFSGPQNIGHLFFVLKPN-LFVGNSFNKRIKDNIKTIKKLPKIKGVKE 300

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I  PG         N +  I +  +V   ++ L
Sbjct: 301 ILYPGQSKFNRFKSNLKKEINISKAVLKDLEYL 333


>UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitobacter
           RepID=A3SYU7_9RHOB
          Length = 356

 Score =  117 bits (292), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 92/341 (26%), Positives = 152/341 (44%), Gaps = 13/341 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L      +L   G D+  A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MAVDAGRLTDFATAILAHAGQDAGRAAKVAARLVGANLAGHDSHGVGMIPAYVDGILAGQ 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A  + +   G     D  R  G++ A++ M  AI+ A  H    ++LRN+ H  R 
Sbjct: 61  LDAAADIELVQDKGPFLLVDGHRGFGHIVAEQAMTLAIDRAQAHHFATLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMP---PWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G +G  AAE G+I I + N  +  P   P+G  + R  TNP   AIP+T   P+ ++DM+
Sbjct: 121 GDWGIMAAEAGFICILYANVQSARPLVAPFGGSDARFVTNPYCTAIPATEKHPMFVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  + G   V +L+G+  P     D +GN T++P V+       +   G  KG G++++
Sbjct: 181 TSTIAMGKARVAQLSGKPAPEGALIDAQGNATRDPSVVFDGAGGALTAFGQHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTS 290
            D++    S G + A   ++  D   I    +AI +D  + G  +     +    D+V +
Sbjct: 241 GDILGGSFSGGGAYAP-EREVPDR--IVNNMMAILIDPNVFGLAQSFGVDVDSYTDWVKA 297

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           +  A     ++ PG       AE    GI +D    A++ A
Sbjct: 298 SPAAPGTAGVQFPGDPERRSTAERSAKGIPLDAGTLAQLTA 338


>UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobacteriales
           RepID=COMC_METTH
          Length = 341

 Score =  117 bits (292), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 89/333 (26%), Positives = 159/333 (47%), Gaps = 12/333 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E+       +L +  V  E++D  A++       G  SHG+ RFP+++  L +G 
Sbjct: 1   MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D          +    +     G++ A + M+ AIE A + G+GLV + ++NH+   
Sbjct: 61  IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G Y   A     IG+   N+   + P G ++  +GTNP+ + IPS    + VDM+ S  +
Sbjct: 121 GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA 180

Query: 180 YG-MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            G +LE  R  G  +P +   D EG  T +P +  K   ILP G  KG  +S +++++A 
Sbjct: 181 RGKLLEAAR-KGESIPENVALDAEGKPTTDPEMALKG-SILPFGGHKGYALSFMIEILAG 238

Query: 239 LLSDGASVAEVTQDNSDEYGISQ--IFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            L   A    VT   + E   ++  + +AI+  K++D     A++   ++ V S+     
Sbjct: 239 PLVGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSS----- 293

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              + +PG   +  +   R  GI +D+ +  +I
Sbjct: 294 -GDVLIPGDIESMNIKRRRAEGIELDEKLLERI 325


>UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FR90_DESHD
          Length = 349

 Score =  117 bits (292), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 75/298 (25%), Positives = 137/298 (45%), Gaps = 6/298 (2%)

Query: 40  GVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE 99
           G+ SHGV+RFP ++++++ G + P  Q         + + D    +G++     ++R +E
Sbjct: 44  GIKSHGVSRFPVYLRRIQMGAVNPQPQISMEQRTPVLLKVDGDNGLGSVVMVHALNRGME 103

Query: 100 LAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL 159
           LA   GI  V ++ +NH    G Y   AAE+G + I  T+     PPWG ++   GTNP+
Sbjct: 104 LAEQLGICAVGIKGSNHCGASGYYCELAAEQGLVSIVLTDGPPATPPWGGRKAYFGTNPM 163

Query: 160 IVAIP--STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR 217
              +P    P  +VD++ S+ + G +      G ++P     D EG  T +P        
Sbjct: 164 AFGLPRAQKPHIIVDLATSLAARGKVIRAAAQGEKIPEGWALDREGLPTTDPQAALAG-V 222

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDG 274
           +LPM   KG  +S+V++ +A +L     G  VA    + +    +    I ++ D  ++ 
Sbjct: 223 LLPMAGAKGYALSLVVEHLAGVLVGAGFGKDVAWQYSEGNKPANVGHFIILVKADAFMEM 282

Query: 275 PTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                + ++ ++ +     A   + I+LPG             GI +D  + A +Q +
Sbjct: 283 ADYHKRTEQFVEEIKKIPLAPGTKEIKLPGERSWEQQQNTEAQGIILDADLQAALQTI 340


>UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKI2_VARPS
          Length = 350

 Score =  116 bits (290), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 82/310 (26%), Positives = 147/310 (47%), Gaps = 8/310 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+   L+     +  S+G+ +  A + A+        GV SHGV   P +++++  G 
Sbjct: 4   VSVSVHALRGLTAALFRSQGLTALRAASVADSLVCADLEGVASHGVALVPLYLERISKGS 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P  +   G +    AQ ++G ++A   ++ A   A +HG+ +V++R+A H+   
Sbjct: 64  VDPHAEPLVVEDHGGLVVMSAQNALGQVSAAVAVELAAARAREHGVSVVSVRHAFHFGTA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
             +  Q A  G +G  ++N+  +MP  G  E  +G NP+ +AIP+    P+ +VDM+MS 
Sbjct: 124 SYWARQFAAAGMVGFAFSNTRPLMPAPGGAERVVGNNPMAIAIPARVDEPL-VVDMAMSA 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G + +    G  +P     D  G  T           +LP    KG G+++ +D++ 
Sbjct: 183 TAMGKIRLAEANGEAIPTGWATDAAGRATTS-ATEAIQGMLLPAAGPKGFGLAVAIDLLC 241

Query: 238 TLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             LSD   GA+V  +  +    Y  S  FIAI+  +L  G     ++      +  + RA
Sbjct: 242 GALSDGAVGAAVRPLYGELDKPYDCSHAFIAIDAARLHGGAGIAPQVAGFAQAIRDSRRA 301

Query: 295 DENQAIRLPG 304
              + I  PG
Sbjct: 302 PGTERIYAPG 311


>UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coelomata
           RepID=C3ZIE6_BRAFL
          Length = 360

 Score =  116 bits (290), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 78/312 (25%), Positives = 148/312 (47%), Gaps = 12/312 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  +++ A   R + + G     A A A+        G +SHG+NR   ++Q + +G  +
Sbjct: 11  VPKQEVIAFVERCMGAVGTPGAHASALAQALMTADYRGHFSHGLNRLDMYVQDIRSGMTV 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +         +    +G + +   MD A+  A D GIG V    +NH+   G 
Sbjct: 71  KDGEPTIVNERAGTAFVNGNNLLGPVVSNFCMDLAMRKAKDAGIGWVVACGSNHYSIAGY 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y  +A ++G +G+ +TN+  ++ P  A++  +GTNP+ VA P       ++DM+ S  + 
Sbjct: 131 YSLKACDQGLVGMSFTNTSPLVVPTRARKGVLGTNPISVAAPGKEGDSFVLDMATSTCAL 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLD 234
           G +E++   G  +P+  G D  G  T +P  + +    + +      G +KG G++++++
Sbjct: 191 GKIELHDRKGLPIPIGWGVDSAGRETTDPKAVLQGGGQMALGGSEVTGGYKGYGLAMMVE 250

Query: 235 MIATLLSDGASVAEVT--QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   +LS GA    V   + N     + Q F+AI+ +     P    ++Q +MD   + E
Sbjct: 251 LFCVILSGGAFGPNVRRWKTNDRVANLGQCFVAIDPEAF--APGFHDRMQDMMDCCRNLE 308

Query: 293 RADENQAIRLPG 304
            A+    + + G
Sbjct: 309 PAEGETEVLVAG 320


>UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2
          Length = 344

 Score =  115 bits (289), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 96/345 (27%), Positives = 166/345 (48%), Gaps = 26/345 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+   + L A    +L   G D  +A A A         GV SHG+ R P ++++LE G 
Sbjct: 1   MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P      +   G +   D +   G   A K ++ A  LA  HG+G V +R + H+   
Sbjct: 61  VNPSPT-LPLEERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMA 119

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y  + A+ G++ +  TN+   + P+G +E  +GTNPL  A P+   I + D++ S  +
Sbjct: 120 GLYAEKLAQAGFLALVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESA 179

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + + R  G ++P   G D EGN T +P  +   R   P+G  KG  +++++++++ +
Sbjct: 180 MGKVFLAREKGERIPPSWGVDREGNPTDDPHRVYALR---PLGGPKGYALALLVEVLSGV 236

Query: 240 LSDGASVAEVTQDNSDEY----GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           L+ GA VA       DE+     +    +A++  + +    ++A L+R M  +  A +A 
Sbjct: 237 LT-GAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVG---KEAFLER-MGALWQALKAT 291

Query: 296 ENQAIRLPGHEFTTLLAE---NRR-----NGITVDDSVWAKIQAL 332
                  PGHE   L  E    RR      G+ + + V A+++AL
Sbjct: 292 PPA----PGHEEVFLPGELEARRRERALAEGMALPERVVAELKAL 332


>UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizobium medicae WSM419
           RepID=A6ULS2_SINMW
          Length = 348

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 90/333 (27%), Positives = 154/333 (46%), Gaps = 10/333 (3%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L+     VL + G+  + A   A+        GV SHGV R   ++ ++  G +  D 
Sbjct: 10  EALRGFTEDVLKAAGMRPQPAATVADTLVYADLRGVSSHGVARLGSYLDRIRAGVMEIDP 69

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           Q + I    A    DA    G +     M+ AIE A   G  ++ + N+NH+     +  
Sbjct: 70  QMRLIREAPASGLLDAGNGFGQIAGMTAMEIAIEKAKSAGSAVIGIANSNHFGVAAYFAE 129

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGM 182
           +A   G +GI  TNS   M  +  +   IGTNP+   IP+    PI ++DMS S+ + G 
Sbjct: 130 RATRAGMVGIVLTNSSPAMTAFNTRIPLIGTNPIAFGIPAGAERPI-ILDMSTSLVARGK 188

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           + +  L G+ +P+   +DD G  T++     K   + P+G  KG+G+S+++D++  +L+ 
Sbjct: 189 IRLASLTGKPIPLGWAYDDRGLSTEDAHAALKG-SLAPIGGPKGAGLSLIIDLLTGVLTG 247

Query: 243 GASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
                EV    D S       + IA +V + I      + +  ++  + +   AD    +
Sbjct: 248 TGLTGEVKNITDISGPSRTGHLMIAFDVSRFISPELFKSSVDSVVANIKAMPSADGGP-V 306

Query: 301 RLPGHEFTTLLAENR-RNGITVDDSVWAKIQAL 332
            +PG E   + AE R R+GI V   +   ++ L
Sbjct: 307 FMPG-EMEAIGAERRARDGIGVPRDIVDTLRGL 338


>UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Burkholderia
           glumae BGR1 RepID=C5A802_BURGB
          Length = 357

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 84/335 (25%), Positives = 152/335 (45%), Gaps = 10/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E+L+       + RG+ +  A   A    RT+  G+ +HGV   P ++++L+ G   
Sbjct: 5   IQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+   + +         DA  + G +        A ELA + G+G+VA+ N+NH+     
Sbjct: 65  PEPALRTVRRFQGTALVDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASV 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           YG   A +G IGI  T++ A M P+ A     GTNP+  A P+    + ++DM+ S  SY
Sbjct: 125 YGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNPICFAAPARDGDLYLLDMATSQISY 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             ++  R  G  LP       +G    +P  +     +  +G +KG G+++++ +++ LL
Sbjct: 185 SQVKHFRRNGMALPSGWALGADGQPVTDPAQVVS---LATLGGYKGQGLAMMVQILSCLL 241

Query: 241 SDGASVAEVTQDNSDEYG----ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +       +T  +++ Y     I    IAI+  +        A +  +M  +     A E
Sbjct: 242 TAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETP-AAE 300

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + +++ G      +A     GI +DD  W  +QA
Sbjct: 301 GERVQVAGDPQKAAIARRTAQGIPLDDDEWRGLQA 335


>UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z109_9NEIS
          Length = 346

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 73/254 (28%), Positives = 121/254 (47%), Gaps = 9/254 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  +QL+     VL + G   + A   +         G  SHG+   P ++  + N  
Sbjct: 1   MKLAAKQLEHVSRLVLKALGCKEKEAVIVSRHLVEANLRGHPSHGIGMLPFYVASVRNKT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GAI Q+  +R  G   A++ +D AI    + G+ L+ +RNA+H  R 
Sbjct: 61  LRPNQAARLVRDAGAILQFSGERGFGQRVAREAVDAAIWRVRETGVALLTVRNAHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTN----SIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDM 173
           G YG Q A  G +G+ + N       ++ P+G    R G NP+ +A P T   P  ++D 
Sbjct: 121 GCYGEQLANAGLVGLFFVNVTDVHTPMVSPFGGTAGRFGGNPICIAFPGTDKHPAFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSI 231
           + S  SYG   V  LAG++       +  G+ + +P V+  E    + PM + KG G+  
Sbjct: 181 ATSRVSYGKTRVAYLAGQRFEEPVLQNHAGHPSHDPRVMWEEPQGTLRPMAHHKGGGLLA 240

Query: 232 VLDMIATLLSDGAS 245
             + +A LLS G +
Sbjct: 241 ATEFLAGLLSGGGT 254


>UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SBU9_9ACTO
          Length = 353

 Score =  114 bits (286), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 80/310 (25%), Positives = 150/310 (48%), Gaps = 9/310 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  + L+A    VL + GV  + A   A+   +    G  SHG+ R P +  +L +G +
Sbjct: 5   RIEPKLLRAFGTGVLTALGVPGDDAALVADSLVQADLWGHQSHGLLRLPWYGARLRSGAM 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++  G +   D +  IG +  ++    A+E A  HG+G+V +RN+NH+    
Sbjct: 65  RAVPEPAVLSDTGPLVLLDGRDGIGQVLTERARRLAVERARTHGVGVVGVRNSNHFGTAM 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM--VDMSMSMFS 179
            +  +AA  G + +  TN+   M PWG +E R+GTNP  +A P    T+  +D++ +  +
Sbjct: 125 WFTRRAAHDGVVAVLTTNASPAMAPWGGREKRVGTNPWSIAAPGPDGTVLALDIANTAVA 184

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEP--GVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            G + + +  G  +P       +G  T +P  GV+     +LPM   KG  ++ ++D+++
Sbjct: 185 RGKIHLAKNRGEPIPDTWALTADGAPTTDPEEGVLGV---LLPMAGHKGYAIAFMMDVLS 241

Query: 238 TLLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
             L+  A    V    +     G   +F+A++ D   D    +A++++++D V S   A 
Sbjct: 242 GALTGSAVGTGVHGPYEPDARSGCGHLFLALDPDAFGDRAGYEARVRQLVDEVASVPLAQ 301

Query: 296 ENQAIRLPGH 305
               +  PG 
Sbjct: 302 GFDGVLHPGQ 311


>UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyces
           RepID=C9Z6D5_STRSW
          Length = 356

 Score =  113 bits (283), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 84/322 (26%), Positives = 145/322 (45%), Gaps = 17/322 (5%)

Query: 18  SRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIE 77
           + GV +  A   A+        G  SHG+ R P ++ +L +G     A P  +T  GA+ 
Sbjct: 20  AHGVPAVDARLLADTLVTAELWGHPSHGMLRLPWYLDRLASGATTAVAAPVTVTDSGAVL 79

Query: 78  QWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICW 137
             D    +G +   + +   +E A  HGI  VA+RN+ H+     +  +AAE+G + +  
Sbjct: 80  VVDGCDGLGQVLTSRAVTWGVERARRHGISAVAVRNSGHFGTAAYFTRKAAEQGCVALLA 139

Query: 138 TNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYGMLEVNRLAGRQLPV 195
           TN+   M PWG +E  +GTNP  +A P       ++D++ +  + G +   R  G  +P 
Sbjct: 140 TNASPAMAPWGGREKSVGTNPWSIAAPGGRHGTVVMDIANTAVARGKIYHARERGEAIP- 198

Query: 196 DGGFDDEGNL-TKEPGVIEKNRR-----ILPMGYWKGSGMSIVLDMIATLLSDGASVAEV 249
           DG   D G + T +P      RR     ILPM   KG  +S + D++A +L+  A    V
Sbjct: 199 DGWAADAGGVPTNDP------RRAIEGLILPMAGHKGYAISFMFDVLAGVLTGSAFGTAV 252

Query: 250 T--QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEF 307
                 +   G+  + I +++  + D    + +++ +++   +   A     I +PG   
Sbjct: 253 VGPYQPTGRSGVGHLLICVDIAAMADPAEFETRMEALIEETKAVPAAPGTAEIFVPGEPE 312

Query: 308 TTLLAENRRNGITVDDSVWAKI 329
                  R  GIT+ D  W  +
Sbjct: 313 ARTAERLRSEGITLTDDTWTSL 334


>UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria RepID=D1BPG4_VEIPT
          Length = 379

 Score =  113 bits (282), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 86/342 (25%), Positives = 152/342 (44%), Gaps = 16/342 (4%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPD 64
           +E LK          G   + AD   ++   +   G+ SHG+ R  R+ + + NG I  D
Sbjct: 12  YETLKKLSMDAFQKFGFSEKEADIIQDVLLTSDLFGIQSHGMQRMVRYHKGITNGLIKID 71

Query: 65  AQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
           A+P+ +         D    +G L   K M+ AIE A   G+G+V++RN+NH+   G Y 
Sbjct: 72  AKPEIVKETPISAVIDGHDGMGQLLGHKAMEMAIEKAKKSGVGIVSVRNSNHYGIAGYYA 131

Query: 125 WQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT-MVDMSMSMFSYGML 183
             A+++G IG   TNS A+M P  A++  +G+NP+   +P+ P+    D S ++ + G L
Sbjct: 132 KMASDQGLIGFSCTNSEAIMVPVYARKAMLGSNPIAWTVPADPVDFFFDCSTTVVTRGKL 191

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR------ILP-------MGYWKGSGMS 230
           E+    G+  P     + +G  + +   +  N        ILP       +G  KG G  
Sbjct: 192 EMYNKMGKATPDGWAVNKDGVPSTDAAEVLGNISRHEGGGILPLGGATEVLGGHKGYGNG 251

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           ++ ++ +++LS G +  +          I   F+AI  +   D         + +  +  
Sbjct: 252 MIAELFSSILSQGGTSNKCMVGGKSN--ICHGFMAINPEFFGDPAEIKKHFSQFLQELRE 309

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           A +A     I   G +    +A+ +  GI V +    ++Q L
Sbjct: 310 APKAQGQDRIYTHGEKEHESVAKVKAEGIPVLNGTMLEVQDL 351


>UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydroxyacid
           dehydrogenase) n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RN53_9RICK
          Length = 349

 Score =  113 bits (282), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 84/338 (24%), Positives = 150/338 (44%), Gaps = 9/338 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K+   +LK+    +L   G++S  A   +EM  R  E GV+SHG+ R P ++Q+L     
Sbjct: 4   KIKIYKLKSLTQAILKKVGLNSINAKVVSEMLVRADERGVWSHGIVRLPVYVQRLNKNAA 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P  + K      +    +    +G ++A + M + I+LA  +GIGLV + N+NH+    
Sbjct: 64  NPKPKLKFKKISQSAFHLNGDNGLGFISANEGMKKCIQLAKKNGIGLVGISNSNHFGMAA 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS----TPITMVDMSMSM 177
           +Y   AA+   I   +TN+   +PP GA     GT+P   + P+     P  ++DM+ S 
Sbjct: 124 NYLELAAKNNCISWVFTNASKALPPHGAMAPFFGTSPFAFSCPTKNKNKPF-ILDMASSS 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G L+       ++P     D  G  T + G       +LP G  KG+G+S ++D++A
Sbjct: 183 VARGKLKFAAQNNIKIPFGYALDKFGKPTND-GQKAFEGIMLPFGGMKGAGLSWMMDIVA 241

Query: 238 TLLS---DGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
            + +       V     D S    +  + I +  +          K++  +  V   ++A
Sbjct: 242 GIFTGANHSGKVKNAINDFSGPANVGHLMICMRTNLFQSHKNFIKKIEYGIKQVKQLKKA 301

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + I  PG          +R+GI +      +++ L
Sbjct: 302 KGFKKILHPGEPEYLNEMRLKRSGINLSKETVIELKKL 339


>UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1
           RepID=A1HMI4_9FIRM
          Length = 355

 Score =  112 bits (281), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 85/321 (26%), Positives = 147/321 (45%), Gaps = 12/321 (3%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           GV  + +   AE       +GV SHGV+R P +++++    + P    + ++   +    
Sbjct: 25  GVPRDESYINAENLVDADLTGVESHGVSRMPIYLKRIRMNAVNPRCTLRTVSESPSTAVI 84

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           DA  S+G +   K M+ AIE A   GI  + ++N+NH+     +   A +   IG   TN
Sbjct: 85  DACNSMGAVVGVKTMELAIEKAKKTGISFIVVKNSNHYGTAAYHAKIALKHNMIGFTATN 144

Query: 140 SIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRLAGRQLPVD 196
             A M PWG K+   GTNP  VA+P+    PI + DM+ S+ + G + +       +P+ 
Sbjct: 145 GAARMAPWGGKDPFFGTNPFAVAVPAGKHLPI-IADMATSVVALGKIILAAKKNLPIPLG 203

Query: 197 GGFDDEGNLTKEPGVIEKNRRI---LPMGYWKGSGMSIVLDMIATLLSD---GASVAEVT 250
              +  G  T  P  +   + I   LP G  KGS +++++D++  +L+    G  + ++ 
Sbjct: 204 WALNKFGEETTNPKEVFDGKVIGTPLPFGGPKGSAIALLIDVLTGILAGSTFGPQIKDMY 263

Query: 251 QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTL 310
            D      IS +F AI V+  +      + +  ++  V     A     I LPG E    
Sbjct: 264 ADFDQPTTISHLFGAINVEAFVPVSQFTSSIDELITMVKQVSPAKGVDEIFLPG-EIELR 322

Query: 311 LAENR-RNGITVDDSVWAKIQ 330
             E R   GI + ++V   ++
Sbjct: 323 KKEKRLAEGIPISEAVLEDLR 343


>UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria RepID=B0UBJ7_METS4
          Length = 351

 Score =  112 bits (280), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 87/311 (27%), Positives = 149/311 (47%), Gaps = 7/311 (2%)

Query: 24  ETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQR 83
           + A  CA+   +    G  SHG+ R   +  +L  G   P A P+ +   G +   D + 
Sbjct: 27  QDAALCADSLVQADLWGHQSHGMMRLSWYAARLAAGVCDPRAVPESVVDAGGLAVIDGRE 86

Query: 84  SIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAV 143
           ++G + A + M  A+  AA HGIG VA+RN+NH+     +   AA  G IG   TN+   
Sbjct: 87  AMGQVVAAQAMAEAMARAAAHGIGAVAVRNSNHFGTAMYFTLMAARAGCIGFLSTNASPA 146

Query: 144 MPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFD 200
           M PWG +   +G NP   A P+    P+ + D++ +  + G + + R  G  +P+    D
Sbjct: 147 MAPWGGRRKALGNNPWSWAAPAGRHAPLVL-DIANTAVARGKIYLARQRGEAIPLGWAMD 205

Query: 201 DEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDE--YG 258
             G  T +P     +  ILPM   KGS +S V+D+++ +L+  A  A V      E   G
Sbjct: 206 ASGRPTADPQA-AIDGLILPMAGHKGSAISAVMDVLSGVLTGSAFGAGVAGPYQAERRSG 264

Query: 259 ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNG 318
              + +AI++ ++      +A+++R +  + +   A+  +A+  PG       AEN R G
Sbjct: 265 AGHLALAIDIARIQPLAEFEARMERFIAEMRAVPLAEGAEAVFYPGEIEARAEAENLREG 324

Query: 319 ITVDDSVWAKI 329
           + + +   A +
Sbjct: 325 VLLPEDTRADL 335


>UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Proteobacteria
           RepID=YBIC_ECOLI
          Length = 361

 Score =  112 bits (280), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 80/331 (24%), Positives = 148/331 (44%), Gaps = 9/331 (2%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           + L +    V    G + + A   A+       +G  SHG+   P +++    G +  + 
Sbjct: 10  QTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINH 69

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
             K +   GA    D  R+ G + A + M   IE A  HGI  VAL N++H  R G +  
Sbjct: 70  HAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAE 129

Query: 126 QAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSY 180
           Q A  G++ I + + + +  + P+  ++ R GTNP  V  P   + P+ ++D + S  ++
Sbjct: 130 QCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPL-LLDYATSAIAF 188

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYWKGSGMSIVLDMIAT 238
           G   V    G  +P     D  G  T  P V++++    +L     KG  ++ + +++  
Sbjct: 189 GKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEILGG 248

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
            LS G +  + T   S +  ++ +   I   +L   P  +A+ +   ++V ++   D+++
Sbjct: 249 ALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASPH-DDDK 307

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            I LPG        E ++ GI +D   W  I
Sbjct: 308 PILLPGEWEVNTRRERQKQGIPLDAGSWQAI 338


>UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistosoma
           RepID=C4Q0V1_SCHMA
          Length = 384

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 73/313 (23%), Positives = 151/313 (48%), Gaps = 13/313 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E++K    + L   G   + A A +++       G YSHG+NR   ++Q ++ G   
Sbjct: 30  ISTEEVKKFCIQCLQKVGAQLKHATALSDVLVAGDYRGHYSHGLNRLEMYVQDIQKGVCS 89

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +    +    D +  +G +     M+ AI+ A + GI  VA   +NH+   G 
Sbjct: 90  TDLEPTIVKETVSTALVDGKNVLGPVVGNFSMETAIKKANETGIAFVAAFGSNHFGIAGW 149

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT---MVDMSMSMFS 179
           Y   A ++G IG+ +TN+  ++ P  A+   +GTNP+ +A P        ++DM+ S  +
Sbjct: 150 YSLMALQQGLIGLAFTNTSPLVFPTRARRLAVGTNPITLAAPGKVPEDHFVLDMATSAVA 209

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVL 233
            G +E++R  G ++P   G D +G  + +P ++     ++P+G       +KG G+ +++
Sbjct: 210 LGKIEMSRRRGIEIPKGWGADTDGKTSVDPNLVMTKGGLMPLGGEEENSGYKGYGLGMLV 269

Query: 234 DMIATLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++  +++D A    + +         + Q F+AI+       P  + +L   ++ + + 
Sbjct: 270 EILCGIIADAAFGPNIRRWLSTDKPANLGQSFLAIDPKAF--APGFEQRLSEYVNIMRNL 327

Query: 292 ERADENQAIRLPG 304
              D  + + +PG
Sbjct: 328 PPVDNQKPVIVPG 340


>UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VWV3_9CLOT
          Length = 410

 Score =  111 bits (278), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 83/339 (24%), Positives = 160/339 (47%), Gaps = 21/339 (6%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           ++ +A  +++  + G + + AD  A+        G  SHG+NR P + Q+LE+G    + 
Sbjct: 60  KESQAYVSKLFQTIGAEKKHADVVADHLTMAEMRGQASHGLNRIPFYTQKLEHGGYKANP 119

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
             K +     +   DA  ++G ++    M+  +E A+  G   VA+ ++NH      Y  
Sbjct: 120 HMKILREDAGVALLDADDALGAVSCSHAMELCMEKASRTGCASVAVTHSNHIGFLAYYTM 179

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGM 182
            AA++  IGI   NS +    WG +E  +GT+P  + +P+    P+ ++D + S+ + G 
Sbjct: 180 MAAKRNMIGIAVCNSGSSTAVWGTRERVLGTDPFSIGVPAKKHFPV-ILDCATSVVAQGK 238

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRI---LPMGYWKGSGMSIVLDMIATL 239
           + V     + +P +  ++  G    EP  +     +    P G +KGSG++IV+ +I   
Sbjct: 239 VSVAETENKPIPGNWAYNKNG----EPTTVASEAMVGTMRPFGDYKGSGIAIVISLICAG 294

Query: 240 LSDGASVAEVTQDN----SDEYGISQI---FIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           L+      +  ++N    SD    S++    IAI++ K  D      ++   +D V S +
Sbjct: 295 LT--GMPFDFEEENLRRISDLSAGSELAASLIAIDISKFTDAEAFKHRVDGFIDVVKSFK 352

Query: 293 RADENQAIRLPGH-EFTTLLAENRRNGITVDDSVWAKIQ 330
            A + + I +PG  EF  + A     G  +  +++ K++
Sbjct: 353 LAPDTEQIYMPGEIEFNKVAANRAAGGFEIGPNLYQKLK 391


>UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomicrobium roseum DSM
           5159 RepID=B9L199_THERP
          Length = 353

 Score =  111 bits (277), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 88/343 (25%), Positives = 156/343 (45%), Gaps = 17/343 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+L+     V +  G+  E A   AE+       G  SHGV R   +++++E G 
Sbjct: 3   VRLPVEELQRFVTEVFLRTGLSEEDAAISAEILVAADVRGFDSHGVARLDYYVRRIEAGA 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +   +    A   +DA   +G  +A + M R IE A + G+ L  +R +NH+   
Sbjct: 63  VNLRPRFHAVAETPATIAFDADNGMGFPSAYRAMRRCIEKAQESGLCLATVRRSNHYGIA 122

Query: 121 GSYGWQAAE-KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMS 176
           G Y   A E  G IG+  TN+  ++ P  A++  + T P+  AIP+    P+   D + S
Sbjct: 123 GYYATMALEVPGMIGVSMTNATPLVVPPHARDAYLSTAPIAFAIPAGKERPLVF-DGATS 181

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYW------KGSGMS 230
             ++G +E+ R   + +P+    D EG  T +P      R + P+G +      KG  ++
Sbjct: 182 TVAWGKIEIARRNRQPIPLGWALDAEGRPTTDPFA---ARFLTPLGAFPELRSHKGYALA 238

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEYGIS---QIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           ++++++   L+ G     V    S+  G S     F+AI +D         A +  ++  
Sbjct: 239 LLVEVLCGQLAGGVWAKYVGGSRSETIGPSNTGHAFMAIRIDAFRPLEEFLADMDDMLGE 298

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  A   D  + + +PG       AE R NGI V   V A ++
Sbjct: 299 LRRARPTDGAERVLVPGDLEAETEAERRANGIPVHPEVLATLR 341


>UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella petrii DSM 12804
           RepID=A9I6A1_BORPD
          Length = 312

 Score =  110 bits (276), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 77/299 (25%), Positives = 143/299 (47%), Gaps = 13/299 (4%)

Query: 35  RTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMM 94
           +T+  GV SHG+ R P ++ +L +G ++   Q + + S  A  Q    + +G + A +  
Sbjct: 2   QTSLWGVDSHGIARLPHYLNRLAHGSVLARPQVRVVRSGPATAQVHGGQGLGIVVAHRAN 61

Query: 95  DRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRI 154
             A+E+A + G+  V + +++H    G Y   AAE G +G+ +T+S A+  P+G     +
Sbjct: 62  RLAMEIAREAGVAAVGVSDSSHCGAVGLYSRAAAEAGLVGLAFTHSDAIAAPFGGHAPFL 121

Query: 155 GTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI 212
           GTNP+ VA+P    P   +DM+ +   +  +   R  G  LP     DD G    +P ++
Sbjct: 122 GTNPISVAVPRQDGPPACLDMASTAIPWNRVMNARREGHALPEGVALDDTGRDATDP-LV 180

Query: 213 EKNRRIL--PMGYWKGSGMSIVLDMIATLLSD---GASVAEVTQDNSDEYGISQIFIAIE 267
            +  R L  P   +KG G++++++++   L+    G  ++ + +       +   FI I+
Sbjct: 181 ARALRPLGGPQQGYKGYGLALMIELLCGPLNGNPFGPHISPMYEQLDKARRLGAFFIVID 240

Query: 268 VDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVW 326
             +   GP   A + ++     +AE A +    R+PG           R GI V+  +W
Sbjct: 241 PARFAGGPLLAAVVAQM-----AAELAAQPGQPRMPGDPEQAAQVSRLRGGIPVEPGLW 294


>UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Bacillus
           RepID=YJMC_BACSU
          Length = 337

 Score =  110 bits (275), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 84/338 (24%), Positives = 162/338 (47%), Gaps = 12/338 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E+ K    + L   G++   A+  A++        V+SHGV     ++ +L  G 
Sbjct: 4   ITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLAGG 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQP    +       D     G++     MD AI++A   G+G+V   N++H    
Sbjct: 64  INPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
             +  +AA++  IG+  T++ +++ P+G +   +GTNP+   +P+    P  ++DM+ S 
Sbjct: 124 SYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPAKHKKPF-ILDMATSK 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++G +   R  G+++P   G D+ G    +P   +K   +   G  KG G+SIV+D+ +
Sbjct: 183 VAFGKILQAREEGKEIPEGWGVDENGEAVTDP---DKVVSLSTFGGPKGYGLSIVVDVFS 239

Query: 238 TLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
            LL+    G  +A++      +  +     AI      D  T   ++  ++D +  +  A
Sbjct: 240 GLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFFTDWDTFLEQMDAMIDELQQSPPA 299

Query: 295 DENQAIRLPGHEFTTLLAE-NRRNGITVDDSVWAKIQA 331
              + + +PG E   L  E N++NGI++  SV+  +++
Sbjct: 300 VGFERVYVPG-EIEQLHEERNKKNGISIARSVYEFLKS 336


>UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C5R1_9PLAN
          Length = 371

 Score =  110 bits (275), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 79/321 (24%), Positives = 144/321 (44%), Gaps = 8/321 (2%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E LK    ++L+   +    A   A+    +   G+ SHGV R P +++++    I P  
Sbjct: 14  ESLKEFCYQLLLQANLTGHDAGLVADTLVESNLRGIDSHGVARLPHYLERIRQQSIQPRP 73

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           + +      A+ + D    +G L   K  D A+ELA D G G V++ N++H      YG 
Sbjct: 74  EMQWEPLGDAVGRVDGDHGLGQLAMVKAADHAVELARDSGAGWVSICNSSHCGALAYYGL 133

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGML 183
           + AE G IG  +T+   ++ P GA E   GTNP+ +  P        +DM+ S+  +  +
Sbjct: 134 RIAEAGMIGFAFTHVDPMVTPHGAAEPFCGTNPICMTAPGKEGKSLCLDMATSITPWNTI 193

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD- 242
                 G  +P D   D  G  T +P  +     + P G +KGSG+ +++D++  LL   
Sbjct: 194 ANAATEGVSIPGDWALDANGRGTTDPNEVVA---LFPFGGFKGSGLGLMIDVLCALLGGA 250

Query: 243 --GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
             G  + ++  D +    +  +  AI++ +  +  T   +++ ++    + +   E   +
Sbjct: 251 PIGPDIPKMYGDLTQRRLLGGMVGAIDISRFTEVETFQDRIEELIQRWGAVKPLKEGGKV 310

Query: 301 RLPGHEFTTLLAENRRNGITV 321
             PG        E  ++GI V
Sbjct: 311 YYPGEPEALTRVERLQSGIPV 331


>UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomyces sp. ACTE
           RepID=D1XHT9_9ACTO
          Length = 360

 Score =  110 bits (274), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 88/326 (26%), Positives = 149/326 (45%), Gaps = 14/326 (4%)

Query: 12  FNRVLISRG-VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRI 70
           F   L+ +G + +E A   A++F      GV SHG  R P +++ L  G  + +A+P+  
Sbjct: 22  FAAALLEKGGLCAEDARTTADVFVWAARRGVDSHGTARVPAYLELLAKG--VANARPEIT 79

Query: 71  --TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAA 128
             ++  A    DA R+ G +   +    A++ A  +GI  V +R   H    G Y  + A
Sbjct: 80  VESTTPAAAVLDADRAPGPVALTRAAREAVDRARTYGIATVGVRRTVHTGAIGYYVSRIA 139

Query: 129 EKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGMLEV 185
           E+G +GI + + +  M   GAK   + T+PL VA+P+T   P+ ++DM+ +  + G +  
Sbjct: 140 EQGLVGIGFVSGMPNMGYTGAKGAAVATSPLAVAVPATGHAPL-LLDMATATIALGKIRQ 198

Query: 186 NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
            +  G  LP       +G  T +P   E+    LP+G  KGSGMS+  +++ ++L     
Sbjct: 199 AKADGTPLPEGAAATRDGTPTTDP---ERAVMPLPLGGVKGSGMSLAFELLTSVLVGAPI 255

Query: 246 VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTR--DAKLQRIMDYVTSAERADENQAIRLP 303
            +    D+       Q  + I VD    G        +   +  + +   AD+   +  P
Sbjct: 256 FSSFHSDDPQGRTHRQNALLIAVDPAAFGGAEAFTEAVDTTLSTLKALPVADDASGVFYP 315

Query: 304 GHEFTTLLAENRRNGITVDDSVWAKI 329
           G     L AE  R GI V   VW ++
Sbjct: 316 GERSAALSAERGRTGIPVAPKVWREL 341


>UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organisms RepID=LDH_RALEH
          Length = 349

 Score =  110 bits (274), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 83/342 (24%), Positives = 151/342 (44%), Gaps = 14/342 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++    +     +L ++ V ++ AD  AE    +   G  SHG++  P +   L+   
Sbjct: 1   MKISLTSARQLARDILAAQQVPADIADDVAEHLVESDRCGYISHGLSILPNYRTALDGHS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  + K +   G +  +D     G    K +M  AIE    HG  +V LR ++H  R 
Sbjct: 61  VNPQGRAKCVLDQGTLMVFDGDGGFGQHVGKSVMQAAIERVRQHGHCIVTLRRSHHLGRM 120

Query: 121 GSYGWQAAEKGYIGICWTNSI---AVMPPWGAKECRIGTNPLIVAIP---STPITMVDMS 174
           G YG  AA  G++ + +TN I    V+ P+G +  R+ TNPL  A P     P  +VD++
Sbjct: 121 GHYGEMAAAAGFVLLSFTNVINRAPVVAPFGGRVARLTTNPLCFAGPMPNGRPPLVVDIA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  +     V    G   P       +GN T +   +  E    +LP G  KG  + +V
Sbjct: 181 TSAIAINKARVLAEKGEPAPEGSIIGADGNPTTDASTMFGEHPGALLPFGGHKGYALGVV 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPT--RDAKLQRIMDYVTS 290
            +++A +LS G +   +  DN      +    A+ ++  +D     + A+++  + Y+  
Sbjct: 241 AELLAGVLSGGGT---IQPDNPRGGVATNNLFAVLLNPALDLGLDWQSAEVEAFVRYLHD 297

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              A     ++ PG E+         + + ++ ++W  ++ L
Sbjct: 298 TPPAPGVDRVQYPG-EYEAANRAQASDTLNINPAIWRNLERL 338


>UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C467_9PLAN
          Length = 356

 Score =  110 bits (274), Expect = 9e-23,   Method: Compositional matrix adjust.
 Identities = 76/308 (24%), Positives = 143/308 (46%), Gaps = 9/308 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++    LK    ++ +  G+    A+  A+        G++SHG     R++  ++ GD
Sbjct: 16  VQIPLGPLKELLVKLFVRMGMFEVEAEIAADRLIEADLRGIHSHGSRTAERYLDSMDMGD 75

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQ   +    AI   D  +S+G++ A + M+ AI+ A + G G V ++N++H+   
Sbjct: 76  IDPRAQILTLKETPAIAVLDGSKSMGHVAATRAMELAIKKAGEVGTGTVVVKNSHHFGAA 135

Query: 121 GSYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMS 176
             Y   A + G IG C TN+  A +   G+ +     N +   +P+    P  + DM+ +
Sbjct: 136 AVYVLMAVKAGMIGYCTTNTGRATVAAHGSTQGATANNAIAWGVPTREGAPFVL-DMACA 194

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             S+G LE   + G  +P     D+EG  T +   +   + +LP    +G G+++V  ++
Sbjct: 195 KTSWGKLETQAMYGLPVPPGYALDNEGKETTDSSTV---KTLLPAAGPRGYGLAMVSSIL 251

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
              L+ G      T+    E G    F  I++ + ++     A+L   +  +      +E
Sbjct: 252 TGALAGGKLPINKTKPPEIE-GSEHFFYVIDLKQFVEEEHFHAELDSAIKAIHQLSTVNE 310

Query: 297 NQAIRLPG 304
           N+ +RLPG
Sbjct: 311 NEPVRLPG 318


>UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaproteobacteria
           RepID=B8IDJ1_METNO
          Length = 378

 Score =  110 bits (274), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 86/347 (24%), Positives = 150/347 (43%), Gaps = 23/347 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +    L A    + +  G  +E A            +G  SHGV R PR++  L  G+
Sbjct: 21  MLIAAAGLTAFVRDIFVGEGCSAEEAGRIGRYLVAANLTGHDSHGVIRVPRYVGWLRAGE 80

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++ D  P+ ++   A    DA    G        +  I  A  +G+ +VALR+A H  R 
Sbjct: 81  VVADRAPEVVSDSAAFVLVDAHYGFGQTAGPFATELGIARARQNGVAIVALRHAGHLGRI 140

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP---STPITMVDMSM 175
           G +  QAA  G + + + N     ++ P+G+ + R  T P     P   + PI ++D + 
Sbjct: 141 GEWAEQAAAAGLVSVHFVNVAGSLLVAPFGSVDRRFSTAPFAAGFPVAGAEPI-ILDFAT 199

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP--------GVIEKNRR-----ILPMG 222
           S  + G + V    G+ LP     + +G L+++P        G  E++ R     I   G
Sbjct: 200 SAVAEGKVLVASQGGKPLPEGVLIEPDGRLSRDPRTLFGPIEGTAERDSRRGEGAIRAFG 259

Query: 223 YWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
             KGSG++++ ++IA  L+   +     +   +  G+  I++  E      G    A+ +
Sbjct: 260 EHKGSGLALMCELIAGALTGSGTAGPGPKRFCN--GMLSIYLTPEA--FGSGDAIAAETR 315

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             +D+  SA  A  +  + LPG       A+    G+ + D VWA +
Sbjct: 316 TYLDFFKSARPASPDGEVLLPGEPERRTRAQRLAEGVPLPDPVWATL 362


>UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax=Aciduliprofundum
           boonei T469 RepID=B5I9V7_9EURY
          Length = 371

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 83/325 (25%), Positives = 154/325 (47%), Gaps = 15/325 (4%)

Query: 21  VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWD 80
           V  E A   A+        G+ SHGV R  R++  ++ G +      K +         D
Sbjct: 39  VPEEDAKIVADNLIMADMRGIESHGVQRLKRYVDGIKVGAVNVHPNIKVVKESPVFAVLD 98

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNS 140
              ++G +   K M  AIE A   G+G+V +RN+NH+   G Y + AA++  +G+  T S
Sbjct: 99  GDEALGQVVGYKGMKMAIEKAKKVGVGIVGVRNSNHYGIAGYYSYMAAKEDLVGVSMTTS 158

Query: 141 IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDG 197
             ++   GA E  +GT+P+ VA P   S P  ++DM+ S+   G +EV R   + +P D 
Sbjct: 159 RPLVAHTGAMEKFMGTSPISVAAPVEGSRPF-LLDMATSVVPSGKIEVYRRKNKPVPGDW 217

Query: 198 GFDDE-GNLTKEPG-VIEKNRRILPMGYW-------KGSGMSIVLDMIATLLSDGASVAE 248
               E G +  +P  ++     ILP+G         KG G+  ++D++A +L +GA+ ++
Sbjct: 218 AISTETGEIIHDPNEILSPKGTILPLGGLGEISGGHKGYGLGAIVDILAGIL-NGATWSK 276

Query: 249 VTQDNSDEYG-ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEF 307
                SD++  +   F+AI+     D       +++ M+ + +A++  + + I + G + 
Sbjct: 277 HVGGTSDKHSDVGHFFMAIDPGAFGDKEEFKKNMRKFMEELKNAKKHPKFERIWVHGEKG 336

Query: 308 TTLLAENRRNGITVDDSVWAKIQAL 332
                   + G+ +   V  ++ A+
Sbjct: 337 FLTYEAREKLGVPIYKKVLDEMNAI 361


>UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C3W7_9FIRM
          Length = 317

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 79/248 (31%), Positives = 127/248 (51%), Gaps = 13/248 (5%)

Query: 16  LISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG--DIIPDAQPKRITSL 73
           L   G+D   A+  A+ FA     GV SHG       I++L+ G  ++ PD +  R T  
Sbjct: 18  LTKHGLDEIQAEVVADCFATADLYGVTSHGCAMTQAHIKRLKCGGYNLKPDFKIMRETDA 77

Query: 74  GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYI 133
            A+   D   S G ++A   ++ AI+   D G+  V  RN N +     Y  +AAE+GYI
Sbjct: 78  FAV--VDGDNSFGPVSAMFCLNLAIKRCKDSGVYTVFSRNNNTFGPAFYYSLKAAEQGYI 135

Query: 134 GICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAG 190
               +NS A M P G KE  +GTNP  V IP     P+ ++DM+ S+ +    +  + AG
Sbjct: 136 AFICSNSPAQMAPIGGKEKMLGTNPFAVVIPVPGHDPV-IIDMATSVVAKSKFKQYKEAG 194

Query: 191 RQLPVDGGFDDEGNLTKEP--GVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAE 248
           + LP     D +G  T  P  G+      +LPM  +KG G+++++D+++ +LS  A + +
Sbjct: 195 KLLPNGWALDKDGKPTNAPDEGI---QGMVLPMAGFKGYGIAMLIDIMSGVLSGAAYLNK 251

Query: 249 VTQDNSDE 256
           V +  S++
Sbjct: 252 VGRFYSED 259


>UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacter heparinus DSM
           2366 RepID=C6Y337_PEDHD
          Length = 364

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 75/283 (26%), Positives = 129/283 (45%), Gaps = 16/283 (5%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           QL+    R     GV  + A   A++ A + E G+ SHG+ R   +   L    I P  +
Sbjct: 14  QLREFSTRTFTYFGVPYDEAVLAADVLAYSDEHGIDSHGIARLKTYFDLLRAKKINPRPE 73

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
            + +    ++   D    +G +   K M+ AI+ A  HG G V++ N NH+   G Y   
Sbjct: 74  LRMLRERASVATIDGDNGLGLVVGPKCMEIAIQKARLHGSGWVSVCNTNHYGAAGYYPVM 133

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGMLE 184
           A +   IG+  TN+   + P+   E  +GTNP+ +A P    P  ++D + S  +YG +E
Sbjct: 134 ALKDDIIGLSMTNTTKGVAPFNGAEKMLGTNPIAIAFPGLKEPPVVIDFASSAVAYGKVE 193

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY------WKGSGMSIVLDMIAT 238
           +      ++P+    D +GN T  P  + +   +LP+G        KG  ++ ++DM++ 
Sbjct: 194 IAGRMAEEMPLGWCIDKQGNPTTSPTDMMQGGALLPLGADKNGSGHKGYCLAAMVDMLSA 253

Query: 239 LLSD---GASVAEVTQDNSDE-----YGISQIFIAIEVDKLID 273
           +LS    G        D++        GI   F A+++D   D
Sbjct: 254 VLSGANWGPFTVPFAIDSAPTERQVGKGIGHFFGAMDIDGFRD 296


>UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=Q125D0_POLSJ
          Length = 364

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 85/340 (25%), Positives = 152/340 (44%), Gaps = 12/340 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++  QL+A    VL + G  +E A   A        SG  SHGV   PR++  +  G + 
Sbjct: 15  ISAAQLRAQVATVLKAAGSSAEEATTVAANLVLANLSGHDSHGVGMLPRYVDAVLEGGLK 74

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P++  + +   G++   D QR  G +  ++ M   I+ A  HG  ++ L NA+H  R G 
Sbjct: 75  PNSSVRVVLDTGSLLTLDGQRGYGQIVGEQAMALGIDRAKAHGSCIMTLGNAHHLGRIGH 134

Query: 123 YGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
           +   A ++G + + + N ++  V+ P+G  + R GTNP  + +P     P  + D + S 
Sbjct: 135 FAEMAVDQGLVSLHFVNVLSRPVVAPFGGGDGRFGTNPCCIGVPLKGREPFVL-DFATSR 193

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR------ILPMGYWKGSGMSI 231
            + G + V    G Q+      D+ G  T +PGV+   +       +L  G  KG GM++
Sbjct: 194 VAQGKMRVAHNKGIQVEPGTLIDEHGRPTTDPGVVVVPQSNGLFGALLAFGEHKGYGMAV 253

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             +++   L+ G +  + T           + I I+  KL      + +    +D++ + 
Sbjct: 254 ACELLGGALTGGGTWHKATDPAVRAVVNGMLTILIDPAKLGTQAAFEQEAVAFVDWLQAG 313

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             A    A+++ G       A+    GI VDD  W ++ A
Sbjct: 314 PVAPGFDAVQIAGDPERATRAQREVEGIAVDDQTWQEMVA 353


>UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenella corrodens ATCC
           23834 RepID=C0DY92_EIKCO
          Length = 358

 Score =  108 bits (270), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 75/296 (25%), Positives = 134/296 (45%), Gaps = 16/296 (5%)

Query: 40  GVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE 99
           GV +HG  R   + Q +  G +   AQP+ +         D   ++G L A+  M  AI+
Sbjct: 44  GVDTHGSQRLEMYRQHINGGFVRIGAQPETVFETPVSAVVDGHAAMGQLVARYAMQIAID 103

Query: 100 LAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL 159
            A   GIG+V++RN+NH+     Y   AA +G +GI  TNS  ++ P   +   +GTNP+
Sbjct: 104 KAKQSGIGMVSVRNSNHYGIAAYYSSMAASQGLVGISMTNSFPIVVPTYGRTPMMGTNPI 163

Query: 160 IVAIPSTPITM-VDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR- 217
            VAIP++P    +D + S+ ++G  EV    G   P+    + +G    +P +I +  R 
Sbjct: 164 AVAIPASPTDFSLDAATSVVAFGKPEVYLKKGLTAPLGWAINSQGVDETDPQIIVECVRQ 223

Query: 218 -----ILPM-------GYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIA 265
                + P+       G  KG G +++++  +  LS G +     ++     GI   F A
Sbjct: 224 GLGGGMYPLGGSSELFGSHKGYGYAVLVEFFSACLSQGTTSNHTMKNG--HAGICHHFAA 281

Query: 266 IEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITV 321
              +   D     +     +  +  + +A   + I + G +      E +++GI +
Sbjct: 282 FNPEIFGDAQAIRSHFSAYLQELRESAKAAGQERIYIHGEKEAECCRERKQSGIPI 337


>UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CEH6_THET1
          Length = 383

 Score =  108 bits (269), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 96/342 (28%), Positives = 147/342 (42%), Gaps = 25/342 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V    LK+    V    GV  E AD  A++       G+ SHGV R  R+  +L  G 
Sbjct: 13  ISVDHMALKSWVTEVFCKLGVPREDADVTADVLVAADLRGIESHGVARLGRYTSRLMKGL 72

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A P  +    +    D    +G   A   M  AI+ A + G G VA+RN+NH+   
Sbjct: 73  ISPVANPVIVRETSSTALVDGNNGLGQPVAMWAMQLAIDKAREVGSGTVAVRNSNHYGIA 132

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT--MVDMSMSMF 178
           G Y   A E   IG+  TNS  ++ P G ++  IGTNP+ VAIP+      ++DM+ S+ 
Sbjct: 133 GYYAMMALEHDMIGMSLTNSSPLVVPTGGRKAVIGTNPIAVAIPAGKERPWVLDMATSVV 192

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI-------------EKNRRILPMGYWK 225
             G LEV     + +P+    D+ G  T +   +                   L  GY K
Sbjct: 193 PRGKLEVYARKNKPMPLGWAVDETGQPTTDAQRVLDALTARLGGGILPLGGTALFSGY-K 251

Query: 226 GSGMSIVLDMIATLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
           G  +S+++D++  +L     G  V E          +   F A+ VD     P  + K Q
Sbjct: 252 GYNLSVMVDLLCGVLPGSNWGPKVDEPVDGKLVPSRVGHFFWALRVDAF--RPIDEFK-Q 308

Query: 283 RIMDYV---TSAERADENQAIRLPGHEFTTLLAENRRNGITV 321
            + DY+     + +A+    I + G +   L  E  R G+ +
Sbjct: 309 EMDDYIRMLKESPKAEGEDRIWVAGEKEWELQEEYSREGVPL 350


>UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000588C5F
          Length = 411

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 72/312 (23%), Positives = 142/312 (45%), Gaps = 12/312 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   +  +   R +++RG +   A   AE+       G +SHG+NR   +++ +E+G   
Sbjct: 24  VKVAEAHSFIERCMVARGTNPTHASLLAELLVSADSRGHFSHGLNRIDVYLENVEHGVTA 83

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  I  +      D +  +G +  +   D  IE A   GIG V  + +NH+   G 
Sbjct: 84  GDGEPVIIKEMAGTAWVDGRNLLGPVVGQFCTDLVIEKAKQAGIGWVVAKGSNHYGIAGW 143

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM--VDMSMSMFSY 180
           Y  +  + G IG+ +TN+   + P  +K+   GTNP+  + P+       +DM+ +  +Y
Sbjct: 144 YSMRIKDTGMIGLSFTNTSPCVYPTRSKQIITGTNPIACSAPANNGDSFDLDMATTTVAY 203

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL------PMGYWKGSGMSIVLD 234
           G +E+  L G+ LP   G + +G  T +P  +     +         G +KG+G++++++
Sbjct: 204 GKVEICHLKGQTLPSGWGSNSDGKETSDPKEVLNGGGLQPLGGGETTGGYKGTGLALMVE 263

Query: 235 MIATLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +I  +L        + +      E  + Q F+A+  +     P    ++  ++    +AE
Sbjct: 264 VITGILGGAHFGTNIRKWSAGEREADLGQCFVALNPEAF--APGFSERMTSLIAMCRNAE 321

Query: 293 RADENQAIRLPG 304
            A+    + + G
Sbjct: 322 PANGETEVLVAG 333


>UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burkholderiales
           RepID=B3R983_CUPTR
          Length = 340

 Score =  107 bits (268), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 81/337 (24%), Positives = 151/337 (44%), Gaps = 14/337 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  ++L+      L   G  +  A A A    R   +G+ SHGV+R P ++  L +  +
Sbjct: 3   RIALQELERVAVAGLRRAGASALQARATALALVRADAAGLPSHGVSRVPMYVAHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+P   ++  +    DA+           +  A+  A   G G+ A+ N++H+    
Sbjct: 63  DGHAEPAVQSTRASAVLVDARCGFAFAACDLAIAEAMARARATGAGVAAVTNSHHFGAAA 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
                 A  G +GI   NS A MP WG K    GTNP+    P     P+ ++D+S+S  
Sbjct: 123 LPLEAVARAGMVGIAMGNSPAAMPAWGGKRPLFGTNPIAAVFPRPGHAPV-VIDLSLSEV 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T
Sbjct: 182 ARGKIMVAARQGKPIPHGWALDEAGQPTTDAQAALRG-SMLPAGGVKGAMLALLVELLVT 240

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+    GA       D  +   I Q+F  ++           A+++ ++  +       
Sbjct: 241 SLAGARFGAEADSFFTDAGNRPRIGQLFFVLDPGAFAGSQVYAARVEALLAAML------ 294

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +++  R+PG    T  A+   +GI V D++W ++QAL
Sbjct: 295 DDEGTRVPGARRDTAQAQAAAHGIEVPDALWRELQAL 331


>UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacillus
           RepID=C6VNL4_LACPJ
          Length = 362

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 80/350 (22%), Positives = 153/350 (43%), Gaps = 24/350 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E  +     V  ++   ++     A+        G+ SHG+ R   + + +++  
Sbjct: 1   MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  QPK +         DA +S+G + +   M++ IE     G+ L  +RN+NH+   
Sbjct: 61  LEPTNQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y   A + G IGI  TN+  ++ P  A E  +G+N L    P+ P   V D + ++ S
Sbjct: 121 GYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR------------ILPMG----- 222
            G ++V    G Q+P D   D+   +  +   +E N              +L +G     
Sbjct: 181 SGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLAKIAFSENRPGGGVLTLGGQQEV 240

Query: 223 --YWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S++++++  +L+ G+  A+    N+ ++  SQ F+ I      D     A 
Sbjct: 241 NSNYKGFGNSLIIELLTGILAQGSLSADT---NTGKHDFSQFFMTINPALFGDPEVLKAN 297

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  + D +   +     + I +PG        EN   G+++D     ++Q
Sbjct: 298 VTTMFDRIRHLKHLPGTK-IMIPGDREYRHYDENLVQGVSIDPQTLTEMQ 346


>UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteobacteria
           RepID=Q46VE5_RALEJ
          Length = 338

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 84/341 (24%), Positives = 152/341 (44%), Gaps = 22/341 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  E+L+      L   G     + A A    R    G+ SHGV+R P ++  L +  +
Sbjct: 3   RIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P   ++  +    DA         +  +  A+  A + G+G+ A+ N++H+   G
Sbjct: 63  DGQAVPTVRSTRASAVLVDAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMF 178
                 A  G +GI   NS A MP WG K    GTNP+  A P     P+ ++D+S+S  
Sbjct: 123 LPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIAAAFPRQGRLPV-LIDLSLSEV 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T
Sbjct: 182 ARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRG-SMLPAGGVKGAMLALMVELLVT 240

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKL----IDGPTRDAKLQRIMDYVTSA 291
            L+    GA       D  +   I Q+F+ ++        + G   +A LQ ++D     
Sbjct: 241 TLAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLD----- 295

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                +   RLPG     L  E +++GI + ++  A++ +L
Sbjct: 296 -----DTGTRLPGARRYALQTEAQQHGIEIPEAQLAELLSL 331


>UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphaproteobacteria
           RepID=Q21D51_RHOPB
          Length = 346

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 86/335 (25%), Positives = 150/335 (44%), Gaps = 13/335 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V  E++++     L++ GV  + AD   ++       G  SHG+ R  R +++++NG 
Sbjct: 1   MIVEAERVRSCAVDALMAAGVLRQDADQQVDLLLEAELRGRPSHGLLRLARIVERIDNGV 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A            + D Q  +G + A   ++     A + G+ +  + NANH    
Sbjct: 61  IDPRASGCHHWKAAGFLEVDGQNGLGPVVALSALEAISLRARETGVAVATIVNANHLGML 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
             Y    A +G   I  + S A++ PWG +   +GTNP+ + +P++P   V DM+ S+ S
Sbjct: 121 AWYAETIARRGLTIIALSISEALVHPWGGRRAMLGTNPVAIGVPASPRPFVLDMASSLVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +  +   G  +P     D +GN T +    +    I P G  KG  + +  +++   
Sbjct: 181 MGQIHDHANRGAPIPGHWALDAQGNATTDAAAAKAG-SIAPFGEAKGYALGLAFEVLVAS 239

Query: 240 LSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY---VTSAERA 294
           L+  A   +V  T D+++      +FI      +IDG +  A  Q I  Y   + +   A
Sbjct: 240 LTGSALGRQVRGTLDSTEVCNKGDVFI------VIDGASSAAMAQVIGGYLEAIRAEPPA 293

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           D   A+ +PG            +GI++ D VWA +
Sbjct: 294 DGFAAVAIPGDRSIAARQRALADGISIADQVWAGL 328


>UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62_BRAJA
          Length = 350

 Score =  105 bits (262), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 89/327 (27%), Positives = 147/327 (44%), Gaps = 14/327 (4%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           +L + G   E ADA A        +G  SHGV   P +I +++ G I+P A    I    
Sbjct: 16  LLQAAGASQEEADAVATGCVNANLAGHDSHGVIAVPTYIDRIKAGHIVPGATWTIIQESP 75

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
                D     G     K M   IE A    +    +   +H  R  +Y   A  +G IG
Sbjct: 76  TTTVIDGHWGFGFHVNAKAMALTIEKAKTANVAACTVFRQSHVGRLAAYPLMAMREGMIG 135

Query: 135 ICWTNS---IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRL 188
           I   +S      + P+G KE R+GTNP+ +A+PS    P  + DM+ S  + G +++   
Sbjct: 136 IATADSGRSPKHVAPFGGKEARLGTNPISIAVPSDLDAPFYL-DMATSAVAAGKIQLAVA 194

Query: 189 AGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG---YWKGSGMSIVLDMIATLLSDGAS 245
            G ++P     D EG  T +P    K   +LP+G    +KGSG++ +++++  LL+    
Sbjct: 195 RGDKIPTGWIIDAEGRHTNDPTQYRKGGALLPLGGTEGYKGSGLAAMVEVLCGLLTGLGF 254

Query: 246 VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGH 305
             E T  ++D   ++ +F       L +     A+  R   Y+ S   ++ +  +  PG 
Sbjct: 255 GVEPTGRHNDGCFMA-VFNVAAFRPLKEFKREVAEFAR---YLKSTPPSEGSTGVYYPGE 310

Query: 306 EFTTLLAENRRNGITVDDSVWAKIQAL 332
                  +  R+GI V+D+ W K++AL
Sbjct: 311 IEGVREQQRLRDGIEVEDATWDKLRAL 337


>UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis S4
           RepID=B9K4F6_AGRVS
          Length = 349

 Score =  104 bits (260), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 89/342 (26%), Positives = 150/342 (43%), Gaps = 24/342 (7%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++ FE L+    R+ ++ G     A+  +   A     G  SHG+ R P ++  + +G +
Sbjct: 13  RLPFEALQNLLKRIFLAAGASEHVANILSANCAGCERDGALSHGIFRMPGYVSSIRSGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A P   T      + DA+     +          E A   GI L+++RN++H+    
Sbjct: 73  DPAAVPVLETGGSGFLRVDARNGFTQVALDFAAQSLKERARQEGIALLSIRNSHHF---- 128

Query: 122 SYGW----QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT--MVDMSM 175
           S  W      AE+  + I   NS A   P+ AK    GTNP+  A P   +   +VDM+ 
Sbjct: 129 SALWPDVVPFAEERLLAIAMVNSFACTAPFDAKVPVFGTNPVAFAAPCDGMVPMVVDMAT 188

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           S  + G +++    G  LP   G D  G  T +P  +     +L  G +KGS +S+++++
Sbjct: 189 SAIANGDVQIAAREGFSLPPGLGIDRSGKPTVDPHAVLDGGALLTFGGYKGSAISMLVEV 248

Query: 236 IATLLSDGASVAEVTQDNSDEYG-----ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           ++  L+ G    EV  D SD  G       Q+ I I+ D       R+A+  R + ++  
Sbjct: 249 MSAALTGGKFSYEV--DWSDYPGAQTPHTGQLVILIDPDV-----GRNAQFSRRVRHLV- 300

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            ER    +  RLPG         + R G+ +  S   +++ L
Sbjct: 301 -ERLRLAKVSRLPGDRRLVTRERSMREGVCLQKSDLERMELL 341


>UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 Tax=Proteobacteria
           RepID=A1WAI4_ACISJ
          Length = 350

 Score =  104 bits (259), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 90/346 (26%), Positives = 148/346 (42%), Gaps = 28/346 (8%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            V F+ L+    R+    G  +E A   A   A     G +SHGV R P ++  L +G +
Sbjct: 13  HVPFDDLRGTLARIFERHGTSAEVAAVLAHNCASAERDGAHSHGVFRIPGYLSTLASGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+           DA         +      +  A  +G+ L+A+RN++H+    
Sbjct: 73  DGRAVPRVEDVAPGYLAVDAGNGFAQPAYRAAYSALVAKARANGVALLAIRNSHHFAALW 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMF 178
                 A+ G + +   NS+A + P G      GTNP+  A P     P+ + D++ S  
Sbjct: 133 PDVEPLADDGLVALALVNSMACVVPSGGTTALFGTNPIAFAAPRAGHEPL-VFDLATSAI 191

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMSIVLD 234
           ++G +++    GR LP   G D  G  T +P  I     +LP G     +KGS +S++++
Sbjct: 192 AHGDVQIAAREGRLLPDGHGVDRHGQPTNDPRAILDGGALLPFGGVHSSYKGSALSMMVE 251

Query: 235 MIATLLSDGASVAEVTQDNSDEYG-----ISQIFIAIEVDKLIDGPTRDAK---LQRIMD 286
           ++A  L+ G    E   D S   G       ++ IAI+       P + A     QR  D
Sbjct: 252 LLAAALTGGNFSFEF--DWSGHPGAQTPWTGELIIAID-------PAKSAGRSFAQRCED 302

Query: 287 YVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            V +   A +    R PG       A + ++GI +  + WA++Q L
Sbjct: 303 LVQAMAAAGQT---RQPGERRYRQRARSLKDGIPLPATTWAELQRL 345


>UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine bacterium EB0_35D03
           RepID=A4GHI0_9BACT
          Length = 335

 Score =  104 bits (259), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 79/329 (24%), Positives = 146/329 (44%), Gaps = 17/329 (5%)

Query: 11  AFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRI 70
           AFN  L +     E A   A+        G   HG++R P +++Q+  G +     P  +
Sbjct: 16  AFN-ALTNNQTSDENAKEVADALINAEFDGQAGHGLSRIPSYVEQVIAGKVAGKVSPSIL 74

Query: 71  TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEK 130
           +S G++ + DA            +    +     GI   ++  ++H+ + G +  + AE 
Sbjct: 75  SSKGSVIRVDANHGFAFPAISLALSEITKTCKSFGIAAASISRSHHFGQAGRHVERLAEV 134

Query: 131 GYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNR 187
           G IG+ + N+   +PPWG  +   GTNP+  A P   S P+ ++DMS+S  + G + V  
Sbjct: 135 GLIGLMFGNTPKAIPPWGGTQALFGTNPIAFASPRDSSVPL-VIDMSLSKVARGKVMVAN 193

Query: 188 LAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD---GA 244
               ++P D   D +G  T +     +   +LP+G  KGS ++++++++A  L+    G 
Sbjct: 194 QLNEKIPEDWAIDKDGKPTTDAKKALEG-AMLPIGDAKGSALALMVEVLAAGLTGSNFGF 252

Query: 245 SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPG 304
             +       D  G+ Q+ IAI+      G +   + + ++  V       E    RLPG
Sbjct: 253 EASSFLNAEGDAPGVGQLIIAID-PSFFSGESFGERTETLVGAVL------EQPGTRLPG 305

Query: 305 HE-FTTLLAENRRNGITVDDSVWAKIQAL 332
            +         +   IT+   ++ KI+ L
Sbjct: 306 DKRIEKRKVREKSETITISKDLYEKIERL 334


>UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B6BPN1_9RICK
          Length = 332

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 71/278 (25%), Positives = 138/278 (49%), Gaps = 11/278 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T +++     + L++ G + ETA   +E+       G  SHG+ R P ++  L++G 
Sbjct: 4   VSLTLDEIFNLAKKTLVANGCNDETASILSELIKNAERDGSLSHGLFRLPAYVSGLKSGK 63

Query: 61  IIPDAQP--KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWM 118
           I     P  KRI+   ++ + +    +  +   K +    + A ++G+ ++A+ N++H  
Sbjct: 64  INGKGTPEVKRISP--SVIKIEGNNCLAPVVLNKGLPELAKAAKENGVAVLAINNSHHMA 121

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSM 175
                  + AE G +    T+    + P GA +   GTNP+  A P    TP+ + DM+ 
Sbjct: 122 AMWPETEKLAEDGLVAFACTSYKPAVAPAGAIKPLFGTNPISFAWPRPGKTPV-VYDMAT 180

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           +  + G ++V +  G ++P+  G   +G  T +PG I     +LP G +KGS +++++++
Sbjct: 181 ASMAMGEVQVAKREGHKVPLGTGLTKDGKETTDPGEIADGGVLLPFGGYKGSAIAMMVEL 240

Query: 236 IA-TLLSDGASVAEVTQDNSDEYGIS--QIFIAIEVDK 270
           +A  L+ D  S     +DN+D    S  +  +AI  DK
Sbjct: 241 MAGALVGDNFSYETAEKDNNDGGPPSGGEFILAICPDK 278


>UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria RepID=B4EV95_PROMH
          Length = 349

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 80/334 (23%), Positives = 150/334 (44%), Gaps = 14/334 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG- 59
           M ++ +QL       L + G++   AD  A++       G++SHG  R   + +++  G 
Sbjct: 1   MIISKQQLHQLIKNKLHNAGLNENHADIVADVLVHADVKGIHSHGAVRVEYYAERISKGG 60

Query: 60  -DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWM 118
            +  P    +      AI  +D     G++ AK+ M+ AI +A + GI +V +R   H  
Sbjct: 61  TNTHPKFTYQETGPCSAI--FDGDNGAGHVAAKQAMEHAINMAQEKGIAVVGVRRIGHSG 118

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSM 175
               +  QA+  G IGI    S  ++ P+G  E   GTNP+  + PS    PIT  DM+ 
Sbjct: 119 ALSYFVEQASASGMIGISLCQSDPMVVPFGGSEVYYGTNPIAFSAPSADDKPITF-DMAT 177

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           ++ ++G +   R     +P     D+ G  T +P  +   + +LP+   KG G+ +++D+
Sbjct: 178 TVQAWGKILDARAKHSDIPDTWAVDEAGKPTCDPFAV---KGLLPIAGPKGYGLMMMVDV 234

Query: 236 IATL---LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   L  G  V+ +  D +    + Q+ I I      D       + ++M  + S +
Sbjct: 235 LSGILLGLPFGKHVSSMYHDLTQGRELGQLHIVINPAFFTDADLFKKHISQVMAELKSIK 294

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVW 326
            A   + +  PG         + + GI + D ++
Sbjct: 295 PAVGFEQVLYPGENSQLAAQRSEKEGIEIVDEIY 328


>UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobacteria
           RepID=B1K2F1_BURCC
          Length = 349

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 76/298 (25%), Positives = 134/298 (44%), Gaps = 8/298 (2%)

Query: 40  GVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE 99
           G+ +HG +R   +  +L  G I P           A+ + D    IG L   + +D A+ 
Sbjct: 48  GLRTHGTSRIESYGSRLRIGGINPAPSITTEQVAPALYRLDGDNGIGPLVGHRALDLAMT 107

Query: 100 LAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL 159
            A + GI  V +R +NH+     Y + AA +G+  I  +N+   + PWG  + R+G +P+
Sbjct: 108 AAREQGIACVFVRGSNHFGPVSPYSYLAAMQGFASIIGSNATTTIAPWGGTDARLGNSPV 167

Query: 160 IVAIPST---PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR 216
              +P+    P  M+DM++S+ +   +      G  +P D   D +G  T +P     + 
Sbjct: 168 GFGVPNPNGRPF-MLDMAISVAARAKIRNALKRGEPIPGDWATDAQGKPTTDPKA-ALDG 225

Query: 217 RILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLID 273
            +LP+G  KG G+++V+D+ A LLS  A +  V     D      +   FI I+  +L  
Sbjct: 226 FLLPIGGHKGYGLALVVDLFAGLLSGAAYLTHVKSWEDDPEQPQNLGHFFILIDTTRLGS 285

Query: 274 GPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                A++      +  ++ AD    + +PG      L      GI +  +  A ++A
Sbjct: 286 TGWLAARMADYAAILHGSQPADPEAPVIVPGEIELGRLERQMAEGIDIGAAQLAMLEA 343


>UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=3
           Tax=Alphaproteobacteria RepID=B6IQH9_RHOCS
          Length = 339

 Score =  103 bits (257), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 78/337 (23%), Positives = 152/337 (45%), Gaps = 13/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++ +      L++     +TA A A    +    G   HG++R P +  Q  NG 
Sbjct: 6   IRMTLQEAEGLAMDALVACRTSPDTARATARALVQAEADGQKGHGLSRVPCYAAQSRNGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A+P       ++ + DA            +     LA   GI L  +  ++H+ + 
Sbjct: 66  VDGFARPSVRKLAPSVLRVDAAHGFAYPALDLAVAEIAPLARSQGIALATIHRSHHFGQA 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVA--IPSTPITMVDMSMSMF 178
           G+   + A++G +G+   N+   M  WG ++  IGTNP+ +A  +P  P  ++DM++S  
Sbjct: 126 GAVVERLADRGLVGLLLGNAPKAMAFWGGRQPMIGTNPVAIAAPVPEGPPLVIDMALSQV 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +   +  G  +P     D +GN T +     K   +LP+G  KG+ +++++++++ 
Sbjct: 186 ARGKVMAAQQVGEPIPEGWALDPDGNPTTDAAAALKG-SMLPIGGAKGAALALMVEVLSA 244

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+    G   + +  D      + Q  +AI+     +G      L R+ D + +  R  
Sbjct: 245 ALTSSHFGWEASSLLDDVGPPPDLGQTLVAIDPAPSSEG----GFLSRMGDLIAAFAR-- 298

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +R PG       A   R GIT+  ++ A+I +L
Sbjct: 299 -EPGVRPPGSRRLENRARAAREGITLPPTLHAEILSL 334


>UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH
          Length = 351

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 84/336 (25%), Positives = 148/336 (44%), Gaps = 7/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E L+    R L +RGV ++ A+  A +       G  +HGV R  +++ +LE G   
Sbjct: 6   ISAEALQDFVARALSARGVPTQDANKVAGLMVEADIYGYGTHGVFRLRQYLARLEGGGCN 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P      +    A    D     G+L      D A+E A   GIG V +R  NH      
Sbjct: 66  PAPNISVLQQTVATALIDGDNGFGHLAMAAARDLAMEKARQAGIGWVGVRRGNHAGPLAL 125

Query: 123 YGWQAAEKGYIGICWT-NSIAVMPPWGAKECRIGTNPLIVAIPST-PITMV-DMSMSMFS 179
           Y    AE G +G+     S   +PP+G  +  +GTNP+  + P+  P   V DM+ ++ +
Sbjct: 126 YVRPQAEAGLLGMAAAVGSANHVPPYGGTDLLLGTNPIAFSAPAEGPDPFVFDMATTVAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G ++     G  +P       +G    +P   +    +LP+G  KG G+S+ + ++A +
Sbjct: 186 MGKIKTLLQQGADMPEGWMVGRDGKPLTDP-ARKSEGFLLPIGGPKGFGLSVAIGLMAGV 244

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+    G+ V + T D +      Q  +A++      G       +R+   + ++     
Sbjct: 245 LNGAAFGSDVVDFTSDTTSPTNTGQFVMALDPAAFGLGDGFAETARRVFGEMRASPPLPG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  +RLPG   T      RR G+T++ ++   + AL
Sbjct: 305 HHPVRLPGDGKTQAAETRRRQGLTLNPALRKDLDAL 340


>UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomicrobia
           RepID=B1ZP47_OPITP
          Length = 364

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 76/274 (27%), Positives = 133/274 (48%), Gaps = 27/274 (9%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG--DIIPDA 65
           ++AA+ +    RG   + A A A   A  T  G+ +H   +         +G     P A
Sbjct: 16  VEAAYKK----RGYSGQEAAAGARFCAEATRHGIRTHNALKALHLDHLFGSGAGGCKPKA 71

Query: 66  QPKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
           + +++ T     + W+A R +G  T    ++ A++LA  +G+G+V++ NA H++ GG Y 
Sbjct: 72  KIEKVKTRFRGAQVWNANRKLGQATGYAAIETAMKLADKYGVGMVSVDNAFHYLWGGGYV 131

Query: 125 WQAAEKGYIGICWTNSIAVMP---PWGAKECRIGTNPLIVAIPST-----PITMVDMSMS 176
            +AA +GY  I +TN  A +    P+G K   +GTNP     P+T     PI ++D + S
Sbjct: 132 MEAARRGY--IAYTNCTAALAEVVPFGGKYPTLGTNPHSWGFPTTGAIGYPI-VIDWATS 188

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
           + + G ++     G+QLP     D+ G  T +P    K + +LP G  KG G+S++ +++
Sbjct: 189 VVAMGRVQQLLREGKQLPPGAAVDENGTPTTDP---AKAKYLLPFGAHKGYGLSLMNEIV 245

Query: 237 ATLLSDGASVAEV----TQDNSDEYGISQIFIAI 266
              +  G S+  +    +Q    E G    F  +
Sbjct: 246 GAFI--GGSLPTLRNRWSQVTEGEKGTCCFFFQV 277


>UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN9_DROME
          Length = 503

 Score =  101 bits (252), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 76/296 (25%), Positives = 136/296 (45%), Gaps = 14/296 (4%)

Query: 21  VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWD 80
           V    A+A A++       G +SHG+NR   +I  L        A PK +    A    D
Sbjct: 169 VPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTDGAAVPKILKETPATAWVD 228

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNS 140
               +G +     MD AI+ A   G+G V  + +NH+   G Y  +A ++G +G+  TN+
Sbjct: 229 GLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGWYAIRAMDQGLVGMSMTNT 288

Query: 141 IAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGG 198
             +M P  AKE  +GTNPL +   +T     ++DM+ +  + G +E+ R  G  LP    
Sbjct: 289 SPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAVGKIEIQRRKGAPLPDGWA 348

Query: 199 FDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLDMIATLLSDGASVAEV--- 249
            D  G +T +  +      ++P+G       +KG G+  ++D+++ ++S      +V   
Sbjct: 349 QDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVDILSGVMSGANYSTQVRKW 408

Query: 250 TQDNSDEYG-ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPG 304
           T   +D    + Q+FIA++ +     P  + ++      +  A   D ++ + L G
Sbjct: 409 THAGADSAADLGQVFIAVDPNCF--APNFEERMADFNSRLRGATPTDPSKPVLLAG 462


>UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IPU0_DROME
          Length = 381

 Score =  101 bits (252), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 76/298 (25%), Positives = 137/298 (45%), Gaps = 14/298 (4%)

Query: 21  VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWD 80
           V    A+A A++       G +SHG+NR   +I  L        A PK +    A    D
Sbjct: 47  VPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTDGAAVPKILKETPATAWVD 106

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNS 140
               +G +     MD AI+ A   G+G V  + +NH+   G Y  +A ++G +G+  TN+
Sbjct: 107 GLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGWYAIRAMDQGLVGMSMTNT 166

Query: 141 IAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGG 198
             +M P  AKE  +GTNPL +   +T     ++DM+ +  + G +E+ R  G  LP    
Sbjct: 167 SPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAVGKIEIQRRKGAPLPDGWA 226

Query: 199 FDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLDMIATLLSDGASVAEV--- 249
            D  G +T +  +      ++P+G       +KG G+  ++D+++ ++S      +V   
Sbjct: 227 QDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVDILSGVMSGANYSTQVRKW 286

Query: 250 TQDNSDEYG-ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHE 306
           T   +D    + Q+FIA++ +     P  + ++      +  A   D ++ + L G +
Sbjct: 287 THAGADSAADLGQVFIAVDPNCF--APNFEERMADFNSRLRGATPTDPSKPVLLAGDK 342


>UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular organisms
           RepID=B0EJK3_ENTDI
          Length = 370

 Score =  101 bits (252), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 78/350 (22%), Positives = 160/350 (45%), Gaps = 20/350 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENGD 60
           ++ F++L+     VL+++GV+   A  CA++  +  + G+ +HG+ R    +  +++ G 
Sbjct: 8   RIHFDELEKFIKDVLMAKGVEEPDAARCAKVLIQADKQGMDTHGIQRLKTIYCDRIDCGQ 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +        +         D    +G+  A + M  AI+ A  HG+G+V +RN  H+   
Sbjct: 68  LNTKTVFDIVKETETTAVVDGHNGMGHSIAMQAMQLAIDKAKKHGMGMVVVRNGTHYGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSM 177
           G Y   AA++G IG    N+   + P  + E ++GTNPL+ A PS    P  + D + S+
Sbjct: 128 GYYPQMAAQQGCIGFSGCNARPSVCPCWSVEPKLGTNPLVFAFPSDEGFPFCL-DCATSI 186

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG-VIEKNRR----ILPMGYW-------K 225
              G +E+    G++       D  G +  EPG ++E  ++      P+G +       K
Sbjct: 187 VQRGKIEMYAREGKKCQPGWVCDRSGKVLSEPGPMLEAFQKGTAACYPLGGYGEEMGGHK 246

Query: 226 GSGMSIVLDMIATLLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
           G G +  ++++++ LS    +++   +         + Q F+AI ++        + ++ 
Sbjct: 247 GYGYACDVEILSSALSGANFLSQCGGLRDGKKVPIELGQFFMAINIESFRPLADFEKQVG 306

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            I   + +A +A     I  PG +      E  + G+ + +   ++++ L
Sbjct: 307 DIARELRAAAKAPGATRIYTPGEKEHETFLERSKKGVFIPEVTRSEMEKL 356


>UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular organisms
           RepID=C5CEA5_KOSOT
          Length = 373

 Score =  100 bits (250), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 86/328 (26%), Positives = 152/328 (46%), Gaps = 22/328 (6%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRF-PRFIQQLENGDIIP 63
           F+ L+     V  + GV  E A   A +     + G+ SHGV R  P ++++++ G   P
Sbjct: 13  FDVLENFMVDVFKALGVPEEDAKIVANVLITADKQGIDSHGVGRLKPIYVERIQAGIQNP 72

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
               + +         D    +G++   K M  AIE A  +G+G+VA+RN+ H+   G Y
Sbjct: 73  ITNFEIVRESPTTAVVDGHNGMGHVIGYKAMKLAIEKAKKYGMGMVAVRNSTHYGIAGYY 132

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSY 180
              A ++G IGI  TN+   + P    E  +GTNPL   +PS    P  ++D + S+   
Sbjct: 133 VQMAVDEGMIGITGTNARPSIAPTFGVEPMLGTNPLTFGMPSDEEFPF-ILDCATSVSQR 191

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNL-TKEPGVIEKNRR----ILPMG-------YWKGSG 228
           G +EV   AG+++P      ++G   T    ++E  ++    ++P+G        +KG G
Sbjct: 192 GKIEVYARAGKEIPEGWVIGEDGKTRTDTEQILEDLKKGKAALVPLGGIGEETAGYKGYG 251

Query: 229 MSIVLDMIATLLSDGASVAEVT----QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
            + V+++++  L  G  +  +T    Q N   Y I   FIAI ++   +          I
Sbjct: 252 YATVVEILSAALQGGNFLKMLTGFDEQGNRVPYRIGHFFIAINIEAFTELENFKKTTGEI 311

Query: 285 MDYVTSAERADENQAIRLPGH-EFTTLL 311
           +  + ++++A   + I   G  E+ T L
Sbjct: 312 LRALRNSKKAPGAERIYTAGEKEYLTWL 339


>UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfovibrio
           peptidovorans DSM 11002 RepID=C1TNX4_9BACT
          Length = 362

 Score =  100 bits (250), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 82/319 (25%), Positives = 143/319 (44%), Gaps = 16/319 (5%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           G     A   AE+        V SHGV R   + + LE G    D +P+ +         
Sbjct: 21  GYTESQARITAEVLVEADARAVPSHGVARLAFYRKNLEGGFAFTDREPQVVRETPVSLVV 80

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           D +  IG   A   MDR ++ A + G     +R++NH+   G +  +AA++G + +  TN
Sbjct: 81  DGKSGIGPSVAAFSMDRCVDKALEIGTCSCVVRDSNHYGMAGLWAERAAKRGCMAVAMTN 140

Query: 140 SIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDG 197
           +         KE  +GTNP+ VAIP +   + ++DM+  + ++G +EV     + +P+  
Sbjct: 141 TRKCCIVTFGKERLLGTNPIAVAIPGSGEEMFLLDMATPVVAHGKVEVYDRRKKPMPLGW 200

Query: 198 GFDDEGNLTKEPGVIE---KNRRIL-----------PMGYWKGSGMSIVLDMIATLLSDG 243
             D+ G++T +   IE   K+   L            +G  KG G+ ++++++ + LS G
Sbjct: 201 VVDETGSVTDDASHIEDLFKSESSLGGHLFLGGEGEELGGHKGYGLGLMVELLCSALSLG 260

Query: 244 ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLP 303
               E  Q+     GI+  F A  +D   D       +  I++ V  +E+AD +  I + 
Sbjct: 261 RWSPETFQEPGSGSGITHYFAATRLDVFGDESAIKDSVSSILESVRRSEKADGHDRIFIH 320

Query: 304 GHEFTTLLAENRRNGITVD 322
           G +         R GI +D
Sbjct: 321 GEKEREARERAVREGIELD 339


>UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5TC94_ACIDE
          Length = 376

 Score =  100 bits (250), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 92/341 (26%), Positives = 155/341 (45%), Gaps = 22/341 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            + F +L+A   ++ +  G   E A   A   A     G  SHG+ R P ++  L +G +
Sbjct: 39  HIAFAELQALLTQIFLRHGTSPEVAAILAANCASAQRDGADSHGIFRIPGYLSTLASGWV 98

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRA----IELAADHGIGLVALRNANHW 117
              A P+           DA    GN  A+  ++ A    I+ A  +GI L+A+RN++H+
Sbjct: 99  NGRAVPQVEDVAPGYVAVDA----GNGFAQPALEAARGLLIDKARRNGIALLAIRNSHHF 154

Query: 118 MRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
                     A +G + + + NS+A + P G  +   GTNP+  A P     P+ + D++
Sbjct: 155 AALWPDVEPFAREGLVALAFVNSMACVVPTGGHKALFGTNPIAFAAPRAGGDPL-VFDLA 213

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLD 234
            S  ++G +++    G +LP   G D  G  T +P  I     +LP G +KGS +S++++
Sbjct: 214 TSAIAHGDVQIAAREGHRLPEGYGVDRLGQPTCDPAAILDGGALLPFGGYKGSALSMMVE 273

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ---RIMDYVTSA 291
           ++A  L+ G    E   D S   G    +   E+  +ID P++ A  Q   R    V   
Sbjct: 274 LLAAALTGGNFSFEF--DWSQHPGAKTPWTG-ELLIVID-PSKGAGNQFARRTETLVQHM 329

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             A +N   R PG       A++ R+GI +     A++  L
Sbjct: 330 RGAGQN---RQPGDRRYQQRAQSDRDGIAITGEELARLHEL 367


>UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TSK9_9PROT
          Length = 338

 Score =  100 bits (249), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 60/235 (25%), Positives = 116/235 (49%), Gaps = 8/235 (3%)

Query: 14  RVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSL 73
           RV ++  VD +TA   AE   R    G+ SHG+ R P + +Q  NG +   A+P    + 
Sbjct: 15  RVFVNSKVDPQTARVVAEALVRAEADGISSHGIARVPPYAEQAMNGKVDGFAKPTVTRTA 74

Query: 74  GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYI 133
            A+   D++        +  ++RA E+  + GI  + +++++H+   G +   AA +G +
Sbjct: 75  AAVLDVDSRIGFAFPAIRLGLERAAEIVKETGIVAIGIKHSHHFGVAGHHVEDAANRGLM 134

Query: 134 GICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAG 190
            + ++N+ A + PWG  +   GTNP+  A P     P  ++D+S+S  + G + +    G
Sbjct: 135 ALAFSNTPAAIAPWGGSKALYGTNPIAFACPRGDGRPPLVIDLSVSTVARGKVVLADKTG 194

Query: 191 RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMSIVLDMIATLLS 241
             +P D   D  G+ T +  V      + P+G      KG+ + ++++++   L+
Sbjct: 195 EAIPDDWALDANGHATTDAKVALTG-SMAPLGGRTAGAKGAALGLMIELLCGALT 248


>UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricaulis maris MCS10
           RepID=Q0ART3_MARMM
          Length = 355

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 81/334 (24%), Positives = 138/334 (41%), Gaps = 10/334 (2%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L A    VL+  G   + A+  A         G  SHGV   P +   +  G +  DA 
Sbjct: 12  NLTAFCTAVLVRAGARVDDAECVARHLVEANLKGHDSHGVGILPAYAGHIRRGQVCLDAD 71

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
              +T    + + DA    G    ++++ +A   A   G+    L NA+H  R G+Y  Q
Sbjct: 72  DTVLTDTTVLLRVDAGGGWGAPAGQRLIHQAGAKAKSGGLAAATLGNAHHLGRIGAYAEQ 131

Query: 127 AAEKGYIGICWTNSIAVMP---PWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSY 180
           A+E G I + + N     P   P+   + R GTNP+ +  P+T   P  ++D++ S  + 
Sbjct: 132 ASEAGLISMHFVNVTDHAPLVAPYRGSDARFGTNPVCIGFPATDTRPAFLLDIATSQIAL 191

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI---EKNRRILPMGYWKGSGMSIVLDMIA 237
           G   V    G  +P     D +G  T +P  +   E    + P+G  KG G++   +++A
Sbjct: 192 GKARVAANKGLPVPAGSLIDKQGRPTTDPSGMSGFEIEGALTPLGKHKGYGLAFACELLA 251

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            +L  GA   +     S     S   I I+ D   D     A+   +  Y  ++   D +
Sbjct: 252 GVLG-GAGTIQPDHPRSGGLKNSMFSILIDPDAFGDRAWMQAETDAMARYALASPPMDWD 310

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             +  PG     +  +  + GI +D+    ++ A
Sbjct: 311 SPVLYPGDPERAIAGKRGKEGIPLDEVTIGQLNA 344


>UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimonas manganoxydans
           SI85-9A1 RepID=Q1YIU0_MOBAS
          Length = 381

 Score = 99.4 bits (246), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 80/323 (24%), Positives = 158/323 (48%), Gaps = 11/323 (3%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           +L + G+    A   A++       G+ SHG+   P + QQL NG        + +  +G
Sbjct: 44  ILSAWGMSDAHAAVTADVLVAADLMGIDSHGLTLLPLYDQQLGNGGATATPNIEVVHDMG 103

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           A+   D     G +     +D A E A   GI  +++RN+NH+   G Y  + AE+G +G
Sbjct: 104 AVALIDGDAGFGQVPGMMAVDMAAERAGRFGISAISIRNSNHYGAAGVYVRRLAEQGLVG 163

Query: 135 ICWTNSI--AVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGMLEVNRLA 189
           I  T+S+  A + P G    ++GTNP+  A PS    P  ++DM+ S  + G L++ + A
Sbjct: 164 IS-TSSVWRAGIVPTGGLAPKLGTNPIAFAAPSARGQPF-LLDMATSTAAIGKLKLAQRA 221

Query: 190 GRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEV 249
             +LP       +G   ++P +   +  + P+G  KG G++ ++++++++LS GA++  +
Sbjct: 222 ETELPEGWALTRQGTPQRDPNLALLDPLLAPLGGHKGYGLATMVEVLSSVLS-GAALTPL 280

Query: 250 TQDNSDEYGISQIFIAIEVDKLIDG--PTRDAKLQRIMDYVTSAERADENQAIRLPGHEF 307
                 ++ +    +A++   +I G     +A L R++D + + +  D    + + G   
Sbjct: 281 RGKPGQKHDVGHFILALD-PAMIRGSRAAFEADLDRMVDGLRATDPIDPAHPVMVAGDPE 339

Query: 308 TTLLAENRRNGITVDDSVWAKIQ 330
               A+   +GI +   + A+++
Sbjct: 340 YAREADRLAHGIPLSSKLAAQLR 362


>UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochloris marina
           MBIC11017 RepID=B0C6P9_ACAM1
          Length = 355

 Score = 99.0 bits (245), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 89/336 (26%), Positives = 151/336 (44%), Gaps = 12/336 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V+  QL+A    VL +  + SE A A  +   +    G+ SHG+ +   + + L +G 
Sbjct: 5   IQVSAAQLRAFLTAVLANYPLQSEAATAITDHLVQANLWGMDSHGLQQIMGYDKSLRSGR 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  +    T    + + +A R+ G    +  M +AI  A + G+ +V + N+NH+   
Sbjct: 65  INPQPKLHIQTDRPTMIRIEADRAPGQYAGQIAMQQAITKAQEMGMAVVGVTNSNHFGMA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMF 178
           G Y   AA  G IG   +++  V + P+G KE R+G NP    IP+  + +V DM+    
Sbjct: 125 GYYTRMAAAAGMIGFATSDTNVVDLAPYGGKEARLGNNPFSWGIPNGDMPIVLDMAAGTV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA- 237
           S G ++     G  +P + G    G  T E   +  N+   P    KG+GM++V D++  
Sbjct: 185 SGGKIKHFGYQGLPIPPEWGLTAAGETTSEAQAVAVNQAASP----KGAGMALVADLLCG 240

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            LL   A++ +    +    G    F  +++    D      ++   +  +    R D  
Sbjct: 241 PLLGTAAALFKTKSRHDRMNGTGHFFWVMDLAVWSDPEEFAERVGDAIATLKQTPRLDPQ 300

Query: 298 QAIRLPGHEFTTLLAENR-RNGITVDDSVWAKIQAL 332
           Q I  PG E   +  + R   GI V    +A IQ L
Sbjct: 301 QPIYFPG-ELEVVTEQTRIHQGIPVP---YALIQDL 332


>UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacter hongkongensis
           HLHK9 RepID=C1D4D2_LARHH
          Length = 348

 Score = 99.0 bits (245), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 68/238 (28%), Positives = 107/238 (44%), Gaps = 9/238 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+T ++++      L + G  +  A   A         G  SHG+   P ++  +  G 
Sbjct: 1   MKLTADRMRHMAEATLTALGSTAAEARLVAGHLVEANLRGHDSHGIGMLPFYVDSVARGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+  +R  G   A + M  AI       + L+ L  A+H  R 
Sbjct: 61  LHPNQPARLLNDQGAVLQFSGERGYGQRVAVEAMRAAIARVRQTQVVLMTLSAAHHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNSI----AVMPPWGAKECRIGTNPLIVAIPS---TPITMVDM 173
           G YG  AA  G++ I + N I     ++ P+G    R GTNPL +A+P     P  ++D 
Sbjct: 121 GHYGELAARLGFVSIHFVNVIDYDQPLVAPFGGTAPRFGTNPLCIALPGGVREPPFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGM 229
           + SM +YG   V  LAGR+       D  G  T +P  +       + PM   KGSG+
Sbjct: 181 ATSMVAYGKTRVAYLAGRRFDTPVMLDAAGQPTADPRAMWESPTGALRPMADHKGSGL 238


>UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0RXU9_RHOSR
          Length = 349

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 59/217 (27%), Positives = 106/217 (48%), Gaps = 2/217 (0%)

Query: 22  DSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDA 81
           D   A   AE   +    G+ SHG+ R P ++++++ G   P+A    ++  G +   D 
Sbjct: 22  DRTRAATTAECIVQADLWGIGSHGLLRLPYYLERMQAGGYPPEADLVTVSDTGPVVALDG 81

Query: 82  QRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSI 141
              +G+    +  + A E  A +G+  V++ N+ H    G Y   A + GYI + ++N  
Sbjct: 82  GGGLGHWQLWRAAELAAERCATYGVAAVSVGNSGHCGALGIYTRAAIDTGYIALTFSNGP 141

Query: 142 AVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFD 200
           AVMPPWG  +  + T+P+   IPS P   ++D++ S  + G +  +   G QLP     D
Sbjct: 142 AVMPPWGGNKPLLSTSPIAAGIPSRPTPAIIDLATSAVARGKIAAHAQNGDQLPDGWALD 201

Query: 201 DEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
             G  T +P    +   + P+G  KG  ++ +++ +A
Sbjct: 202 AHGEPTTDPQAALRG-MLSPLGGAKGFALAFLVEALA 237


>UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobiales
           RepID=Q133C9_RHOPS
          Length = 366

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 77/310 (24%), Positives = 134/310 (43%), Gaps = 22/310 (7%)

Query: 39  SGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAI 98
           +G  SHGV R P +I+    G + PD        L ++   D +   G     + +   I
Sbjct: 45  TGHDSHGVIRVPVYIRWRNAGAVHPDQTVDVPVDLPSLAVVDGKFGYGQTVGPQAVRIGI 104

Query: 99  ELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGT 156
           E     G+  V L+NA H  R G +   AA +G + I +  +    ++ P+G  E R+ T
Sbjct: 105 EKCKAQGLSAVGLKNAGHIGRIGDWAEMAAAEGLVSIHFVTAAGSILVAPYGGVERRLST 164

Query: 157 NPLIVAI--PSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP----G 210
            P  V +  P  P  ++D + S+ + G + V    G+ LP     + +G  +++P    G
Sbjct: 165 APYCVGVPRPGAPPVVLDFATSIVAEGKVLVAARGGKALPQGALINPDGTFSEDPATLYG 224

Query: 211 VIEKN---------RRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQ 261
             EK+           I   G  KGSG++++ +++   LS   +      D     G+  
Sbjct: 225 AFEKDGPINHVNGAGAIRAFGEHKGSGLALICELLGGALSGNGATGP---DRPFANGMFS 281

Query: 262 IFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITV 321
           I+  ++  ++      DA++ R +DY  SA+       + +PG       A+   NG+ +
Sbjct: 282 IY--VDPQRIDPAHVFDAEVTRYVDYFKSAKTVAGVDQVLIPGDPELKTRADRTENGVPL 339

Query: 322 DDSVWAKIQA 331
            D  WA I A
Sbjct: 340 SDDTWAAIVA 349


>UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C1C568_DROME
          Length = 399

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 70/291 (24%), Positives = 125/291 (42%), Gaps = 3/291 (1%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
            L+  GV        +E        G Y  G+NR   ++  L++G     A+P  I+   
Sbjct: 60  CLLRVGVSPSKVRCISEFLVVADYRGNYGSGLNRLDYYLSDLQSGHAKVGAEPSIISETV 119

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           +    +   ++G       MD A++ A D GIG V  + ++       + ++AA KG  G
Sbjct: 120 STAHVNGNSALGVFVGNFCMDLAVKKAEDSGIGFVVAQQSHDIGMASWFTFRAAGKGLAG 179

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLAGRQL 193
           I  +NS   M    +K   IG+N     +       V DM+ S+   G +E        +
Sbjct: 180 IVMSNSAPTMMGPNSKSASIGSNCFAFCVKGEEYHFVLDMATSVKDIGAVEWAWANDEYI 239

Query: 194 PVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDN 253
           P     ++ G  T  P +  +   + P G  KG  +S V+D++  +LS       +T D 
Sbjct: 240 PHGWAANEGGLSTCFPSLALRTPLLFPAGGHKGYCLSAVIDILCGVLSGAQYATHITMDQ 299

Query: 254 SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPG 304
           +    + Q+FIA++ +  +  P    +       + +++ AD+++ IRLPG
Sbjct: 300 NQPSNLGQVFIALDPEFFL--PNFMERFDDFCGRIQNSQPADDSEPIRLPG 348


>UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromonas sp. JS666
           RepID=Q125C6_POLSJ
          Length = 353

 Score = 97.4 bits (241), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 83/333 (24%), Positives = 153/333 (45%), Gaps = 23/333 (6%)

Query: 13  NRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITS 72
           +++L + G+ +  AD  A +   T     ++HGV   P +I QL+NG +  D +P+ +  
Sbjct: 17  SQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLMGTDGEPEVVRD 76

Query: 73  LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGY 132
            GA   WD     G     K +  A E  A HG+   A+R ++H     +   QA ++G 
Sbjct: 77  TGATVVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLAALVKQATDRGL 136

Query: 133 IGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGMLEVNRLA 189
           + I  T+      + P+G ++  +  NP  +  P S    +VD+  S+ +  M      A
Sbjct: 137 VAILATSDPGGKFVAPFGGRDPVLTPNPFAIGYPGSKAPVLVDICASITTVSMARTKAAA 196

Query: 190 GRQLPVDGGFDDEGNLTKEPGVIEKNR---RILPMG----YWKGSGMSIVLDMIATLLSD 242
           G Q       D+ G  T +P V+E+      +L +G      KG G++++++ +   L+ 
Sbjct: 197 GVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKGFGLALMVEALTQGLAG 256

Query: 243 GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD----ENQ 298
              +     D  + +G + +F+ +   +   G  RD  L + MD++  A RA      + 
Sbjct: 257 HGRI-----DAPNRWG-ANVFLQVMDPEAFAG--RDNFLTQ-MDFIGDACRASTPVQPDG 307

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            +RLPG + +  +A  ++ GI + D+   K+ A
Sbjct: 308 LVRLPGDQASGNIARAQQQGIALSDATLDKLAA 340


>UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family protein n=34
           Tax=Enterobacteriaceae RepID=B7UIS0_ECO27
          Length = 336

 Score = 97.1 bits (240), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 73/277 (26%), Positives = 130/277 (46%), Gaps = 14/277 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI- 61
           V+ E LK+  +  L + G+D++T     ++      +GV+SHGV     +  +L  G + 
Sbjct: 6   VSEENLKSLVHHKLHTAGLDTDTTQQVTDVLVHADITGVHSHGVMCVEHYCTRLAAGGLN 65

Query: 62  -IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             P    ++I+   AI   D+   +G+       + AI+LA   G+G V+++N +H    
Sbjct: 66  KAPQFSIEQISPSVAI--LDSDDGMGHSALITATEHAIKLAQQEGLGFVSVKNTSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
             +      KG + I  T +   + P G  E  +GTNP+    P   S P+ +VDM+ S 
Sbjct: 124 SYFAEMITNKGLVAIVMTQTDTCVAPHGGAERFLGTNPIAFGFPVENSHPM-IVDMATSA 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++G +   +  G+ +      D  G  T +P  IE    +LP G  KGSG+++ +D + 
Sbjct: 183 TAFGKILHAKETGKHIGEGLAIDKNGYGTTDPYKIE---NLLPFGQHKGSGIALAIDALT 239

Query: 238 TLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKL 271
            +L +   G  +  +  D      ++ + IAI+  KL
Sbjct: 240 GVLMNANFGNHIVRMYGDYDKMRKLASLVIAIDPKKL 276


>UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteobacteria
           RepID=Q1GLV8_SILST
          Length = 344

 Score = 96.3 bits (238), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 85/337 (25%), Positives = 154/337 (45%), Gaps = 16/337 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T  ++++     L++ G     A   A   A T   GV SHG+   P + Q +E G + 
Sbjct: 16  LTLSEIESLAFDALVAAGTSPANARPLAVATAMTEADGVASHGLAYIPIYAQHVECGKVD 75

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK      A+   DA     +       ++ I LA + G+ ++A+ N+ +    G 
Sbjct: 76  GQANPKVAHPRPAVITVDAATGFAHRAIDLGFEQLIPLAKEMGVAVLAVNNSYNCGVLGV 135

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFS 179
           +  + A+ G +G  +TN+ A + P G  +  +GTNP  ++ P    T   ++D S S  +
Sbjct: 136 HTQRLAQAGLMGFGFTNAPASIAPSGGAKPVVGTNPFSISAPGSDGTAALLIDQSASTIA 195

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
              +  +   G+ +P     D +G  T +P    K   ++P G +KG G+++ ++++A  
Sbjct: 196 KSEVMKHAREGKPVPQGWVLDADGQPTIDPDAGLKG-SMVPSGGYKGVGIALTVELLAAA 254

Query: 240 LSDGASVAEVTQDNSDEYG----ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           ++ GA++  V    S   G      Q FIAI+ D      T     Q  +  + SA R D
Sbjct: 255 MT-GATLGAVASPFSGTAGGPPKTGQFFIAIDPDA-----TSGGLFQEKLADLISAFR-D 307

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ A RLPG    +        G+ V+ ++  +++AL
Sbjct: 308 QDGA-RLPGDGRQSARLRAATEGVRVNAALLERVRAL 343


>UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=5 Tax=Klebsiella
           RepID=B5Y2B5_KLEP3
          Length = 336

 Score = 96.3 bits (238), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 84/325 (25%), Positives = 148/325 (45%), Gaps = 15/325 (4%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           VL + G  ++ A A A         G  SHG+ R    +  L  G + PDA+P+      
Sbjct: 18  VLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGKVSPDAEPQIHDQAP 77

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           AI + DA  +   L  ++ +   +E A  +GI  +A+    H+    +      E G +G
Sbjct: 78  AIARADAGGAFSLLAYERALPLLLEKARQNGIAALAINRCVHFSALFADIEPLTEAGLVG 137

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGR 191
           +  T S A + P G      GTNP+    P     P  +VDM+ S  + G +++++ AG+
Sbjct: 138 LACTPSHAWVAPAGGTRPLFGTNPIAFGWPRRDKQPF-IVDMATSAAARGEIQLHQRAGK 196

Query: 192 QLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA-TLLSDGASVAEVT 250
            LP   G D +G  T +   +  N  +L  G  KGS ++ +++++A  L+ D  S   + 
Sbjct: 197 ALPQGWGIDSQGQPTTDAAEV-LNGAMLTFGGHKGSALAAMVELLAGPLIGDMTSAESLA 255

Query: 251 QDNSD---EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEF 307
            DN      YG  ++ +A++  + +      A+ Q  +    +   A ++Q  RLPG   
Sbjct: 256 WDNGAGGLPYG-GELILALDPQRFL-----GAQAQEQLARAETLFNAMQDQGARLPGERR 309

Query: 308 TTLLAENRRNGITVDDSVWAKIQAL 332
                ++ + G+T+  S+  +I AL
Sbjct: 310 FACRQQSEQQGVTISRSLHDEICAL 334


>UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacterium radiobacter
           K84 RepID=B9JPX6_AGRRK
          Length = 340

 Score = 96.3 bits (238), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 64/240 (26%), Positives = 112/240 (46%), Gaps = 6/240 (2%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPD 64
           +E +      +L   G  + +A   A   A   + G  SHG+ R   ++  +++G +  D
Sbjct: 6   YETVVETLELILTKHGYSARSAGILALNCATAQQDGSESHGLFRIKDYLAIIKSGYVNGD 65

Query: 65  AQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY- 123
             PK +       + DA      +      +R ++ AA++GI +VA+RN++H   G  Y 
Sbjct: 66  PNPKVVDVAPGFIRVDADNGFAQIALADAKERLVQKAAENGIAIVAIRNSHHL--GALYL 123

Query: 124 -GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
                A++G++ +   NSIAV+ P G +    GTNP+  A P    P  + D + S  S+
Sbjct: 124 DVEDLADRGFVSLAVVNSIAVVAPPGGRAGVYGTNPMAFAAPRAEGPPLVFDQASSTMSH 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G ++V    GR LP   G D  G  T  P  I     +   G  KG+ ++++++++   L
Sbjct: 184 GDVQVAAREGRLLPEASGIDKRGIPTNSPHAILNGGALSTFGGHKGASIALMVEILCAAL 243


>UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba RepID=C4M213_ENTHI
          Length = 365

 Score = 95.9 bits (237), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 85/321 (26%), Positives = 135/321 (42%), Gaps = 25/321 (7%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENGDI 61
           V+ + +K    +VL+  G D E A    +        G+ +HG+ RF   +I +++ G I
Sbjct: 9   VSIDTIKEFMYQVLLKVGSDEENARMVRDTLIAADLRGMDTHGIQRFKTVYIDRIKKGMI 68

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A+P  I         D     G++     M  AIE A  +G+G+V +RN+ H+   G
Sbjct: 69  NPTAKPSIIRETSTTCVLDGNNGFGHVNGTIGMKMAIEKAKKYGMGMVVVRNSTHFGIAG 128

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFS 179
            Y   AA++G IGIC TN+ + +      E  +GTNPL + IPS        D + S+  
Sbjct: 129 YYSLLAAQEGCIGICGTNARSSVAATFGDEPILGTNPLAIGIPSDEAFPYCFDGATSISP 188

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR-----RILPMG---YWKGSGMSI 231
            G  E     G+ +         G   ++P  + +N       + P+G      GS    
Sbjct: 189 TGRFEKYVRMGKTVDKSWASMKGGKPIEDPKELLENYPKGKAYLHPLGGSDEVSGSHKGY 248

Query: 232 VLDMIATLLSDGASVA------EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIM 285
            L     ++S   S+A      E  ++ S ++ +   FIAI V+   D       L    
Sbjct: 249 CLSEFVEIMSSCLSIANFLNHIEEEKEKSGKFSLGHFFIAINVECFRD-------LNEFK 301

Query: 286 DYVTSAERADENQAIRLPGHE 306
             V    R   N   +LPGH+
Sbjct: 302 KNVGDINRTLRNTD-KLPGHD 321


>UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UCA9_SINMW
          Length = 356

 Score = 95.9 bits (237), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 91/301 (30%), Positives = 141/301 (46%), Gaps = 19/301 (6%)

Query: 40  GVYSHGVNRFPRFIQQLENGDI--IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRA 97
           GV SHGV     + + L  G +   P+   +R  +  A+   D   ++G+  A   MD+A
Sbjct: 44  GVDSHGVRLVVHYDRVLRGGRVNGTPNLSVRRTAAATAV--VDGDNALGHHAAYVAMDKA 101

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           IELA + GIG V +  ++H+   G+Y   AAE G IG   TNS  V+ P+  +E   GTN
Sbjct: 102 IELARESGIGAVGVIRSSHFGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTN 161

Query: 158 PLIVAIPSTPIT--MVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           PL  A PS      ++DM+ S      L + +  G  LP     D+ G  T EP    + 
Sbjct: 162 PLAFAAPSGGARPWLLDMATSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEP---FEG 218

Query: 216 RRILPMG----YWKGSGMSIVLDMIATLLS----DGASVAEV-TQDNSDEYGISQIFIAI 266
           R +LP+G     +KG+ ++ V  +++ +L     D A +  V T D S    +    +AI
Sbjct: 219 RTLLPLGGVDFSFKGAALAGVATLLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAI 278

Query: 267 EVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVW 326
           + D+       D  +   ++ + SA  A E   +  PG     + A  R+NGI +D    
Sbjct: 279 DPDRFGGRGVFDEGMSAYLEALRSAP-AQEGCEVLAPGDREWRVEAARRQNGIPIDPDTA 337

Query: 327 A 327
           A
Sbjct: 338 A 338


>UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0SCF8_RHOSR
          Length = 358

 Score = 95.1 bits (235), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 82/314 (26%), Positives = 136/314 (43%), Gaps = 13/314 (4%)

Query: 16  LISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGA 75
           L+  GV  + AD  A     T+  G+ +HG+   P+++ +L  G     A P  +   GA
Sbjct: 25  LVEAGVPEDDADLVAAALVDTSLRGIDTHGLRLLPQYLDELATGVANAAACPTVVRDRGA 84

Query: 76  IEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGI 135
               DA  ++G L        A + A   G+  V +RN+NH+     Y    A +G IGI
Sbjct: 85  GLLLDADGALGVLAGLAATRLAADRAKAFGVAAVGVRNSNHFGAASVYTRHLAGQGMIGI 144

Query: 136 CWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYGMLEVNRLAGRQLP 194
             T++ + + P+G  E   GTNP+ VA  +    + +DM+ S   +G ++  R  GR L 
Sbjct: 145 AVTSAASRVAPYGGVEPLFGTNPISVAAGTGDDGLALDMATSQVCFGEVKHRRAEGRPLG 204

Query: 195 VDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA------SVAE 248
                D  G  T EP   ++   + P+G +KG G+++ + ++  +L+          V E
Sbjct: 205 SGWATDRGGLPTAEP---DEAYALSPLGGYKGQGLAMAVTLLGAVLTGSPPDWQLEQVGE 261

Query: 249 VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFT 308
            T   S   G+    +A++           A L  ++D V  +  A     +  PG    
Sbjct: 262 GTPGRS--RGVGHFVLALDPGAFSGHAHFAAGLADLLDTVRGSTPATGTPVV-APGDPQR 318

Query: 309 TLLAENRRNGITVD 322
               E R  GI +D
Sbjct: 319 AHERERRVRGIPLD 332


>UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UJP8_SINMW
          Length = 331

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 88/338 (26%), Positives = 152/338 (44%), Gaps = 23/338 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++++ E+++A     L   G  +  A   A   A    +G    G+   P F + L  G 
Sbjct: 4   VELSREEIEAVCLAALTVHGAAAGNARPVARAIAMAEAAGNRVCGLYYLPIFCRHLAIGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+ +++ G     DA+    +          I+LA  +G+G +A+RN+ + +  
Sbjct: 64  VDGGAIPE-VSARGVTVTVDARSGFAHPAIAAGTPALIDLARSNGLGAMAVRNSYNCLAL 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
           G +    A+ G IGIC +N+ A + P GA     GTNPL  A+PS   TP  +VD S+S 
Sbjct: 123 GHHVHPLADAGLIGICVSNAPAAVAPPGAAAALFGTNPLAFAVPSKEGTPAILVDQSLSA 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            +   + + R  G  +P     D  G  T +   I     +LP G  KG+ ++++++++A
Sbjct: 183 VTKTEMILRRDRGEAIPAGWAQDRNGQPTTD-AAIGLEGSLLPAGGRKGANVALLVEVLA 241

Query: 238 TLLSDGASVAEVTQDNSDEYG---ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             L+      E +   +DE G   + Q  IAI+      G        R  + + +   +
Sbjct: 242 AALTGSVLSTEASAFGNDEGGPPHVGQFLIAIDPGHFSAG--------RFSEAIDNLVAS 293

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            E   +RLPGH         R+  + VD  +W K++ L
Sbjct: 294 HEAAGVRLPGH-------SGRKQAVFVDADLWKKVRLL 324


>UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus cellulosilyticus
           DSM 2522 RepID=D2LY27_BACS4
          Length = 367

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 71/312 (22%), Positives = 143/312 (45%), Gaps = 15/312 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +++L+    ++    G+    A   AE   +    G  SHGV R   ++++++ G I
Sbjct: 4   RFHWKRLETFCEKLFTKAGLPENDAKIVAESLVQADLQGTDSHGVVRADIYLRRIQAGMI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D +   +   G +   D +  IG++   + ++ AIE    HG   V ++ +NH+    
Sbjct: 64  NRDEE-MEVHYDGPVILLDGKNHIGSVVGNRALELAIEATKQHGTASVGVKGSNHFGTCS 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMF 178
            +  +A ++  I I  +N+   MPP G     +GTNPL +  P+    P  ++DM+ S+ 
Sbjct: 123 YFLQKAIKENIIMIIVSNASQTMPPTGGIRPFLGTNPLSIGAPAGRYAPF-ILDMATSVV 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR---RILPMGYWKGSGMSIVLDM 235
           + G +      G+ +P +   D  GN    P  + ++     +LPM   KG  +S+ +D+
Sbjct: 182 ARGKIISAAQKGKSIPKEWAIDKFGN----PTTVAEDALEGSVLPMAGPKGYAISMFIDI 237

Query: 236 IATLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +L+    G  V  + ++  D   +   +I IE+ K +       ++ +  D +    
Sbjct: 238 LSGVLTGAGFGRYVNNMYENWEDPQNVGHFYIGIEISKFMPIEEFKNRIDQYFDEIKREP 297

Query: 293 RADENQAIRLPG 304
           +A   + I +PG
Sbjct: 298 KAPNVEEILIPG 309


>UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CRX3_9FIRM
          Length = 356

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 90/337 (26%), Positives = 152/337 (45%), Gaps = 20/337 (5%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP-DA 65
           +LK    ++ ++ G+    A A +E+        V SHGV R   ++++++ G      A
Sbjct: 10  KLKEYTTKLFLAAGLAQTDAQAVSELLVHADLRNVRSHGVLRTVPYLEKIQKGGASKTSA 69

Query: 66  QP--KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            P  K  T+   I   DAQ  +G L  +K +  A E A    + +V +RN+NH+  G  +
Sbjct: 70  YPVVKETTNSAVI---DAQGGLGALAGEKAVAIAREKAKTALMSMVVVRNSNHFGMGAHW 126

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSY 180
             + A    IG   + +   M P G KE  +G NP  VA  +    P   VDM+ S  + 
Sbjct: 127 ALKLAGNDMIGFACSTTDLTMGPPGCKEPFMGNNPFAVAFKAGEKYPEFCVDMATSGVAL 186

Query: 181 GMLEVNRLAGRQLPVDGG--FDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           G  +   LA R  P+  G   D  GN T +   +E    + PM   KG G+++++++ AT
Sbjct: 187 G--KCKDLAKRGKPIPSGWMLDKNGNDTTK---VEDCYMMTPMAGHKGFGIALIVELFAT 241

Query: 239 LLSDGASVAEV-TQDNSDEYGI-SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           LLS G    ++  QD  D   + SQ F  I +    D        +  +D +      + 
Sbjct: 242 LLSGGVLSPDINNQDLPDVPELSSQCFGCINISAFRDLAEFQETAENYIDRLHQIPMKEG 301

Query: 297 NQAIRLPGH-EFTTLLAENRRNGITVDDSVWAKIQAL 332
               + PG  E+T+ L  N + G+ + +++   + A+
Sbjct: 302 AGDAKYPGEIEYTSKLI-NLKEGVVLPETLTEDLMAI 337


>UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=C1DFD6_AZOVD
          Length = 372

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 92/352 (26%), Positives = 155/352 (44%), Gaps = 33/352 (9%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV  + L+     VL + G+ +  A+  A +   T  +G+ SHGV+  P +    E G  
Sbjct: 8   KVGADALRELTAAVLAAWGMPAVAAEETAALIVETDLAGIDSHGVSMLPFYETLREAGGW 67

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           +PDA+P+ +         D    +G+ TA + M  A + A   G+G VA+RN+NH+   G
Sbjct: 68  VPDAEPRVVRESPCTALLDGGHGLGHRTAMQAMRLAADKAQGVGLGAVAVRNSNHFGAAG 127

Query: 122 SYGWQAAEKGYIG-ICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
            Y   AAE+G IG +  T    ++ P  A+   +GTNP+  A P+    P  + DM+ + 
Sbjct: 128 LYARAAAERGLIGLVASTTRSPMLVPTRARVPVLGTNPIAFAAPARRNRPFVL-DMATTT 186

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDD-------------------EGNLTKEPGVIEKNRRI 218
            +   ++V  L G+ +P     D+                   EG LT   GV E     
Sbjct: 187 VAANKVKVYDLQGKDIPPGWVVDEAGRPVTAGERAMEYLFRRPEGGLTALGGVAE----- 241

Query: 219 LPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRD 278
             +G  KG G+ ++  ++A  L   A  A    D  ++  I   F+A++     D    +
Sbjct: 242 --LGSHKGYGLGMLAQILAGPLCGAAFGARREAD--EKPNIGHFFLALDPRAFRDADEFE 297

Query: 279 AKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
            +L  I+D + +   AD    + + G           R GI + D + A+++
Sbjct: 298 DELDAIVDALHATPAADPALPVLVAGDPEAQTRETRLREGIPLPDRLQAQLR 349


>UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccus denitrificans
           PD1222 RepID=A1BBM1_PARDP
          Length = 356

 Score = 93.6 bits (231), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 90/345 (26%), Positives = 150/345 (43%), Gaps = 30/345 (8%)

Query: 2   KVT--FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG 59
           KVT   +++ A    VL + G+  + A+A A++  R       SHG+ R   ++  L  G
Sbjct: 22  KVTMRLDEIFALVLSVLTANGLSRDQAEAIADIVTRAEADACRSHGLYRVEGYVAGLRAG 81

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            + P AQP+      A+ Q D  +      A       I  A ++GI  +A+   +H+  
Sbjct: 82  RVNPTAQPRVRRLRPALLQVDGDKGFAPFAANLARPHLIAAARENGIAAMAIARTHHF-- 139

Query: 120 GGSYGW----QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVD 172
             S  W       E G +  C+      + P G     +GTNP+    P     P  + D
Sbjct: 140 --SALWADLEPLVEAGLVAWCFVVGQCSVAPHGGSTPLMGTNPIGFGWPRPDGAPF-IFD 196

Query: 173 MSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIV 232
            + S  + G +E+ RLAG  +P   G D EG LT +P        +LP G  KGS +S++
Sbjct: 197 FATSAAARGDVELKRLAGEPIPAGWGIDAEGRLTLDPAEALSG-ALLPFGGHKGSALSMM 255

Query: 233 LDMIATLLSDGASVAEVT----QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR-IMDY 287
           +++IA  L    +  +V     +D+    G  ++FIA++   L  G +  A  +R  +D 
Sbjct: 256 VELIAGPLIGELTSKQVAALGHRDDGPPPG-GELFIALDPASL--GGSAPAVAERFFLD- 311

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 A     +RLP        + +  +G+ V   +  +I+AL
Sbjct: 312 ------AKAQPGLRLPSERRYVARSRSHASGVGVPSDLLRRIKAL 350


>UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholderiales
           RepID=Q0K2P1_RALEH
          Length = 367

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 68/299 (22%), Positives = 134/299 (44%), Gaps = 13/299 (4%)

Query: 17  ISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAI 76
           ++ G  ++ A   A+       SG  SHGV   PR++   +  ++  + Q   +   G++
Sbjct: 20  LAAGSSAQEARLTADHLVGANLSGHDSHGVGMIPRYVLAWQADELQLNQQVSVLHDAGSM 79

Query: 77  EQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGIC 136
              D  R +G     + M+ AI  A +HG+ ++ LR ++H  R G +  QA   G I I 
Sbjct: 80  LSLDGNRGMGQAVTAQAMNMAIGRAREHGVCVMGLRQSHHLGRVGHWAEQATAAGMISIH 139

Query: 137 WTNSIA--VMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGMLEVNRLAGRQ 192
           + N ++  ++ P G  + R GTNP  + +P    P  ++D + S  + G + V    G  
Sbjct: 140 FVNVLSKPIVAPHGGYDARYGTNPFTIGVPVAGEPPLVLDFATSAIALGKVRVAHNKG-- 197

Query: 193 LPVDGG--FDDEGNLTKEPGVI-----EKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
           +PV  G   D  G  + +P V+          + P G  KG  ++++ +++   ++ G +
Sbjct: 198 VPVAPGCLLDAHGEPSADPAVMYPADGAPQGALRPFGEHKGHVLAVMCELLGAAVTGGHT 257

Query: 246 VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPG 304
           +   T  +      + + I  +  +L +  +   ++    D++ ++        IRLPG
Sbjct: 258 IRPETLRHEHAVWNNMLAIVFDPARLGNSTSFGHEVAAFADWMKASRLQPGQDGIRLPG 316


>UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionaceae
           RepID=Q5E5E9_VIBF1
          Length = 315

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 74/254 (29%), Positives = 125/254 (49%), Gaps = 10/254 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV++ ++K    R  I+ G+  + A+   ++   + + G  SHG+         + +  
Sbjct: 1   MKVSYYEVKERLIRKFIASGLAWDDANWVTDVLISSEQRGDKSHGIKHAKNIFDVINSEC 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            I  AQ   I    +I   D Q SIG + AK+ +D AI+ A  +G   ++LR++NH    
Sbjct: 61  YI--AQAPIIHDERSITILDGQNSIGPIVAKQAIDIAIKKAKKYGTAAISLRSSNHLFSL 118

Query: 121 GSYGWQAAEKGYIG-ICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSM 177
             Y    A    IG IC ++S A+  P  +    IGTNP     PS+  PI ++DMS + 
Sbjct: 119 SHYVRYIANNNMIGFICSSSSPAMAAP-NSLNATIGTNPFAFGAPSSKDPI-VIDMSSTN 176

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL-PMGYWKGSGMSIVLDMI 236
            + G ++  + A   +PV    D+ GN T     IE  +  L P+G +KG  +  ++D+ 
Sbjct: 177 VARGKIKEYKDAELDIPVSWALDEYGNPTT--CAIEALKGTLSPLGGYKGFALGCMIDIF 234

Query: 237 ATLLSDGASVAEVT 250
           +++LS  A   ++T
Sbjct: 235 SSVLSGSAFSTQIT 248


>UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria RepID=Q1GM21_SILST
          Length = 348

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 91/345 (26%), Positives = 152/345 (44%), Gaps = 28/345 (8%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++T ++++A   RVL   G  S    A +EM  R       SHG+ R       +++G I
Sbjct: 10  QLTLDEVRALAERVLTHCGYASAHVAAISEMLYRCQLDDCQSHGLFRLFMCANTMKDGKI 69

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+  +   AI + DA+  +  L  ++ M   IE A  +G+  +A+ N  H+    
Sbjct: 70  DAAASPQIHSEDTAIIRADAREGMSLLAVQEAMPTLIEKARRYGMAALAVNNCFHF---- 125

Query: 122 SYGWQAAE----KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           S  W   E     G  G+    S + + P G  +  +GTNP+  + P     P T  D +
Sbjct: 126 SALWPEVEALSTAGLAGLSMVPSHSWVAPAGGTKGTLGTNPIAFSWPRKGQDPFTF-DFA 184

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLD 234
            S F+ G +E+ + AG+ LP     D+ G  T +P     N  +L  G  KGS +SI+++
Sbjct: 185 TSGFARGEIELYKRAGKPLPEGVAIDERGQPTCDPDAA-LNGAMLTFGGHKGSALSIMIE 243

Query: 235 MIATLLSDG----ASVAEVTQDNSDEYGISQIFIAIEVDKLIDG--PTRDAKLQRIMDYV 288
           ++A  L D      S A   +     Y   QI +A + +K   G     DA+ +R+   +
Sbjct: 244 LMAGPLIDDLISLESEAAAGRPGCAPYH-GQIILAFDPEKFSGGRVAQNDARAERLFADI 302

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
            +       Q  RLP        A N   G + +  +++  ++AL
Sbjct: 303 IA-------QGARLPSQRRYAARARNLERGYLEIPSALYRDLEAL 340


>UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Labrenzia
           alexandrii DFL-11 RepID=B9QUQ5_9RHOB
          Length = 349

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 84/325 (25%), Positives = 153/325 (47%), Gaps = 31/325 (9%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ- 66
           +K+AF    ++ GV    A + A         G   HG +R   +  Q+++G I   A+ 
Sbjct: 29  IKSAF----LAVGVPDLAAQSVANALVAAEAEGQVGHGFSRVEDYAAQVQSGKIAAAAEV 84

Query: 67  ---PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
               K I+SL A    DA           ++++  E+A +HG   + +  ++H       
Sbjct: 85  IISHKGISSLLA----DAGFGFAYPALDAVIEKGSEVALEHGCATMGITRSHHCGALSVQ 140

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSY 180
             + A++G + I   N+ A M P+GAK+   GTNP+  A P     P+ +VD+S+S  + 
Sbjct: 141 VEKLAKQGLMAIMVANAPAAMAPFGAKDPVFGTNPIAFAAPRPGKDPL-VVDLSLSRVAR 199

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGN-LTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           G +   R AG+ +P     D +GN  T     +E    +LP+G  KG+ ++++++++A++
Sbjct: 200 GKVMNARKAGKDIPEGWALDKDGNPTTSAEAALEGT--MLPIGEAKGTALALMVEILASV 257

Query: 240 LSDGASVAEVTQDNSDE---YGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++  +   E +   S +    G+ Q  IA+   K +D     A++  ++  + + E A  
Sbjct: 258 MTGASKSTEASSFFSADGPPPGVGQFLIAM---KPMDTEHFAARIDTLLSLIETMEGA-- 312

Query: 297 NQAIRLPGHEFTTLLAENRRNGITV 321
               RLPG      +A+ R  GI V
Sbjct: 313 ----RLPGSRRAATIAKARVEGIDV 333


>UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB62_OSTLU
          Length = 330

 Score = 90.5 bits (223), Expect = 7e-17,   Method: Compositional matrix adjust.
 Identities = 79/274 (28%), Positives = 132/274 (48%), Gaps = 13/274 (4%)

Query: 63  PDAQPKRITSLGAIEQW-DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG- 120
           PDA+P  +T    +    D +++ G L   +    A E A +HG G+V   N +      
Sbjct: 56  PDAEPMVVTHETKLSAAIDGKKTQGMLVLAEATRVAHEKAKEHGFGIVGTCNTSTSTGAL 115

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y    A++G I IC+  S   + P G+ +   GTNP+ V IPS+   MV DM+ S +S
Sbjct: 116 GYYCKSVADQGMISICFAQSPEFVAPAGSSKAIFGTNPIGVGIPSSEGAMVLDMATSAYS 175

Query: 180 -YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIA 237
            +G+LE  + AGR+LP     D  G LTK+P  +     I    G +K S +++V++++A
Sbjct: 176 WFGVLEA-KTAGRELPDGAAQDKNGVLTKDPNEVLDGGAIRTFDGGYKSSNLALVIELLA 234

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             L   A   ++   N   +G   + + I+  K++     +     +M+ V +A +    
Sbjct: 235 GPLVGAAIEGKLAAKN---WG--NLIMVID-PKMLGQADFEKNAAFVMNRVRNAPKQPGV 288

Query: 298 QAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQ 330
            AI LPG     +   N   G I V+ ++W  ++
Sbjct: 289 DAINLPGERGDAIAKANEAKGEIDVETNLWNNLK 322


>UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VEY1_9BACT
          Length = 372

 Score = 90.5 bits (223), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 68/284 (23%), Positives = 127/284 (44%), Gaps = 18/284 (6%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L++    V I  GV  E A  C+++   +   G+ SHG+ R   +  +++ G   P    
Sbjct: 18  LQSFMQEVFIKLGVPEEEAQICSDVLIASDLKGIESHGIGRLKMYYDRIKAGIQNPVTNI 77

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +    A   WD    +G + +KK M  AI+ A  +G+G VA+RN+ H+   G Y   A
Sbjct: 78  DVLRDKCATAVWDGNNGMGQVISKKAMQAAIDKAEKYGLGAVAVRNSTHFGICGYYAEMA 137

Query: 128 AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMV-DMSMSMFSYGMLEV 185
             +  IG+ ++N+   + P       +GTNP+    P+  P   + D + S+   G +E 
Sbjct: 138 IRQNMIGLVFSNARPSICPTNGVSPILGTNPICFGAPTDLPYPFLYDAATSISQRGKVEQ 197

Query: 186 NRLAGRQLPVDGGFDDEGN-LTKEPG----VIEKNRRILPM-------GYWKGSGMSIVL 233
                ++ P+    D EG   T   G    ++++   +LP+       G  KG G++  +
Sbjct: 198 LAREEKETPLGWAIDLEGKPYTDTKGLLIDLLKQKAAMLPLGGTEEITGSHKGYGLATAV 257

Query: 234 DMIATLLSDGASVAEVTQDNSD----EYGISQIFIAIEVDKLID 273
           +++   L  G  +  +  ++ +     Y +   F+AI ++   D
Sbjct: 258 EILCASLQKGNYLNGLLGEDENGKPAPYRLGHFFMAINIEFFTD 301


>UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacillus
           RepID=C9M4P7_LACHE
          Length = 361

 Score = 90.5 bits (223), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 23/352 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++    K    +V  +R          A+        G+ SHG+ R   +   ++   
Sbjct: 1   MRISSLSEKEFLEKVFAARQFSKSDGALLADTLVDADLRGISSHGIQRLAWYTSMIKEHI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  + K I         DA +++G +       + I+     G+ +  +RN+NH+   
Sbjct: 61  IEPQNKLKVIKETPTSLLIDANKNMGQIATAFAEKQLIKKTQKLGLSVAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y   AA++G IGI  TN+  ++ P  A E  +G+N      P+ P   V D + S+ S
Sbjct: 121 GYYARMAAKQGLIGIALTNTRPLVVPPNATEAFLGSNAFAFTFPAEPHPFVFDGATSIVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------------------ 221
            G ++V     + +P D   DD   +  +   +E N   +                    
Sbjct: 181 SGKIQVLAKNNQPIPGDWAVDDHRRVMHDAQKVEDNLAKVAFTEKQPGGGVLTLGGLLQS 240

Query: 222 -GYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S+V++++  +L+ G+  A+  +    ++  SQ  + I  +   +       
Sbjct: 241 NSNYKGFGNSLVVELLTGILAQGSISADTNKPGHHDF--SQFLLTINPELFGNLDDLKKS 298

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + + D +   +     + I +PG       AEN + G+ +DD   A+++ +
Sbjct: 299 AEEMFDRLRHLKHLPGTE-IMIPGDREYRRYAENLKQGVVIDDKTVAELKTI 349


>UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadecabacter antarcticus
           238 RepID=B5KEU8_9RHOB
          Length = 365

 Score = 90.5 bits (223), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 81/345 (23%), Positives = 154/345 (44%), Gaps = 21/345 (6%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           T + +KA    +L++ G+ ++     AE        G+ +HG++    + +    G    
Sbjct: 7   TPDSIKAQATEILVNWGMSADNVALTAEGMLDCDLRGIDTHGISLLALYDKWRVGGGFAL 66

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
           DA  K +    +    DAQ  +G   + + ++ A   A + G+  V +RN+ H+   G Y
Sbjct: 67  DATDKLLRDGPSYASIDAQGGLGFPVSVRAVELACNKARETGLAAVTVRNSRHFGAAGYY 126

Query: 124 GWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFS 179
               AEKG + +  T++ +  M P GA +  +GTNPL  A+P     P+ + DM+ S  +
Sbjct: 127 ARLGAEKGMMMLVATSTKVVCMVPPGAADAVLGTNPLAYAVPRQNGAPV-VFDMATSTAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI------EKNRRILP------MGYWKGS 227
              + + +L+   +P     D EG    +P +        +   + P      MG +KG 
Sbjct: 186 GNKIRLYQLSNTPVPEGWVVDHEGKSVTDPDIASDIVYGSRPGGLTPLGATPGMGAYKGY 245

Query: 228 GMSIVLDMIATLLSDG--ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIM 285
           G++++   +   L+ G  A       D SD   I   F+A++  K  D    +A +  + 
Sbjct: 246 GLALMGHFLGGTLAGGDFAGSKNRAADASDN--IGHFFLAMDPAKFRDLAAFEADMCDVD 303

Query: 286 DYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           D + +    D ++ I LPG     +  + R+ GI + D++  +++
Sbjct: 304 DSLRATPAVDPDRPILLPGDVERKVADQRRKAGIPLADALVDQLK 348


>UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B8DQ74_DESVM
          Length = 356

 Score = 89.7 bits (221), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 65/250 (26%), Positives = 111/250 (44%), Gaps = 19/250 (7%)

Query: 10  AAFNRVLISR-GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPK 68
           AA  R ++ R GV    A + A         G+ SHGV R P++  Q+  G +  DA P+
Sbjct: 11  AALCRTVLERAGVLPAAASSVAGALVAAECMGIPSHGVARLPQYADQVAAGKVRGDAVPR 70

Query: 69  RITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAA 128
             T L A  + DA         +  +D A+ LA   G   + + N++H    G +  +AA
Sbjct: 71  VETPLPATVRVDAGCGFAYPALEAGLDVAVPLALRMGCAALGVTNSHHCGVAGLHVERAA 130

Query: 129 EKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI-----------------PSTPITMV 171
            +G + + + N+ A M PWG     +GTNPL  A                  P     ++
Sbjct: 131 RQGLVALLFANTPAAMAPWGGNRASLGTNPLAFACPAPPEDAPEPTAAAGAGPEHDPLVM 190

Query: 172 DMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSI 231
           D+S+S  + G +      G+ +P     D  G+ T +         +LP G  KG+ +++
Sbjct: 191 DLSLSTVARGKIVAAAREGQPIPAGWAVDAHGSPTTD-ARAALGGMLLPFGGAKGAALAL 249

Query: 232 VLDMIATLLS 241
           +++++A  L+
Sbjct: 250 MVELLAASLT 259


>UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae bacterium KLH11
           RepID=B9NW20_9RHOB
          Length = 337

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 76/299 (25%), Positives = 129/299 (43%), Gaps = 16/299 (5%)

Query: 13  NRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITS 72
           N VL+  G+D+ ++   A++   +   G  SHG+   P + Q L +G   P A P    +
Sbjct: 19  NSVLVKAGLDAHSSAIIADLVWMSERDGPRSHGLRLLPVYAQYLSSGYANPAASPVIGRA 78

Query: 73  LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA---AE 129
              + + D       + A    D  I +A ++GI      N +H    G+  +     AE
Sbjct: 79  APGVLRGDGDNGFYQVAALAARDDLIAMARENGIAAFTCANCHHL---GALRFDTGPLAE 135

Query: 130 KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV--DMSMSMFSYGMLEVNR 187
            G + +   NS++++ P G      GTNP+  A P      V  D + SM +   +++  
Sbjct: 136 AGLVAMGVVNSLSMVVPQGGVRPTFGTNPMSFACPRPGAEPVVWDQASSMVALMDIKMAA 195

Query: 188 LAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA-SV 246
             G  LP   G D EG  T +P  I + R +LP G  KG+ ++ +++++   L+ G  SV
Sbjct: 196 AEGHDLPRPAGLDPEGQPTTDPNAILETRGLLPFGEHKGAAIAFLVEVLGAALAGGTLSV 255

Query: 247 AEVTQDNSDEYGISQIFIAIEVDKLIDG-PTRDAKLQRIMDYVTSAERADENQAIRLPG 304
              +++      I      I +D    G    D  +QRI   +      + N   R+PG
Sbjct: 256 DNASREAHGALNIKGGATLIAIDPARFGNAAFDQYVQRICAEI------EGNGTARVPG 308


>UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspira
           RepID=C0R1X7_BRAHW
          Length = 334

 Score = 89.0 bits (219), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 71/328 (21%), Positives = 139/328 (42%), Gaps = 8/328 (2%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E + A +N+  ++ GV +E A    ++       G++SHGV R   +I ++++G I  ++
Sbjct: 8   ELMDAVYNKFKMA-GVSNEQAGIVTDVLIYADIRGIHSHGVLRVEHYIDRIKSGGINLNS 66

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           +        +    DA    G++  +  M+ A+E     GI L+ ++N +H    G Y  
Sbjct: 67  EFHIEEKRPSFALMDADGGFGHVATQYAMEWALETVEKQGIALIGIKNNSHAGALGYYNK 126

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGMLE 184
            A ++  + +   N+   + P+G K    GTNP+    P      + DM+ S  S G + 
Sbjct: 127 MAIDQNKVSLIMVNTDPCVIPFGGKRSFFGTNPISYGFPGKKDFILGDMATSEVSLGRIF 186

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
             R     +P+  G D+ GN +  P  I   + ++P G  KG  +  +++    LL    
Sbjct: 187 TARENNETVPMHWGVDENGNPSSNPNEI---KYVVPFGGVKGYLIMTMVEAFTGLLIGQV 243

Query: 245 ---SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
              ++ ++  D   +  +S   + ++     D  T    +Q  +D +       E   I 
Sbjct: 244 YCNNLVKMYGDMDKKRNLSTFMLVVDPAVYNDLDTYLNTVQSFIDDIRKEPALKEGSTIS 303

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +PG           + GI + + ++  I
Sbjct: 304 IPGERKEACSKVYLKEGIPLPEHIYKYI 331


>UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YDL3_MOBAS
          Length = 352

 Score = 87.4 bits (215), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 80/339 (23%), Positives = 152/339 (44%), Gaps = 12/339 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +   L+   N +  + G+  + A    ++       G  SHG+ R P + +++  G +
Sbjct: 3   RFSLATLRPFANALFEASGLSQDHAALVTDVLIHADLRGHGSHGLTRIPIYAERIAAGAV 62

Query: 62  --IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              PD + +R     A  Q D     G + +   ++ AI  A + G+ + A+  +NH   
Sbjct: 63  NARPDIRFERPAP--AFLQVDGDNGPGPVVSDAAVEAAIATAKEQGVCVAAVARSNHNGS 120

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMS 176
           G  Y  +A   G I +  TN+   M  +G ++  IGTNP+    P    TPI M+DM+ S
Sbjct: 121 GSFYVEKAVAAGCIALAMTNAPPSMAVFGGRQAVIGTNPVTFGTPVDGGTPI-MMDMATS 179

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
           + + G +      G  +P     D +G  T +    E+   +LP+   KGS ++I+++++
Sbjct: 180 VVARGKVVEAAKRGEAIPEGWALDADGKPTCDGRAAERG-VVLPLSGPKGSALAIMVEVL 238

Query: 237 ATLLSDG---ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
             +LS G    S+  +  D      I    + I+V ++       A+++ ++  +  +  
Sbjct: 239 CGVLSGGRFAGSLGNLYSDFETPQDIGHFMLLIDVSRIHASSGYAARVRDLVLELKDSAT 298

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           A+    I++PG         N   GI + D+V A + A+
Sbjct: 299 AEGFSEIKMPGEVEMERARSNSAEGIDLPDNVVADLNAI 337


>UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium leguminosarum
           RepID=C6B638_RHILS
          Length = 353

 Score = 87.4 bits (215), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 83/338 (24%), Positives = 152/338 (44%), Gaps = 37/338 (10%)

Query: 13  NRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITS 72
            ++L   G++++ A+  A +       G  +HGV+    +++ LE+G +      + +  
Sbjct: 16  KQILTRAGMEADKAETTAAVLVEGDMIGHETHGVSLLSWYVEALEDGSLAKSGSYEIVND 75

Query: 73  LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGY 132
            GA   WD +   G     K +++A E   DHG+   A+RN +H     ++  Q  E+G 
Sbjct: 76  RGAAFVWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSAFMRQVTERGL 135

Query: 133 IGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEVNRL 188
           I     +  A   + P+G  +  +  NP+    P++  PI ++D+S S+ +  M +    
Sbjct: 136 IVQLSVSHPAASRVAPYGGTKPLLTPNPMAAGFPTSADPI-LIDVSASITTTTMTQNLAK 194

Query: 189 AGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG----YWKGSGMSIVLDMIATLLSDG 243
           AG++ P    F   G  T +P  V E+   ++P+G      KG G+ ++++++   LS G
Sbjct: 195 AGKKFPEAWAFTVAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGLGLIVELLGQGLS-G 253

Query: 244 ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIM---DYVTSAERAD----- 295
              A            S +F      ++ID P   A L       D++ SA R++     
Sbjct: 254 KGRANTP---------SGVFSQSAFLQVID-PAFFAGLDAFTAQSDFLASACRSNPPAPW 303

Query: 296 ENQAIRLPGHEFTTLLAENRRN----GITVDDSVWAKI 329
            N  +R+PG       A+ RR+    G+ V D+ W K+
Sbjct: 304 NNGPVRMPGDS----AAQKRRSALEEGVPVGDAAWQKL 337


>UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1SWJ6_PSYIN
          Length = 339

 Score = 87.4 bits (215), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 77/310 (24%), Positives = 141/310 (45%), Gaps = 15/310 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T E++       L+S+G + E A A A         G  SHG+ R P +I  L++  
Sbjct: 6   INLTLEEIYDLAKTALLSQGANEENAAAIANTVTIAERDGAISHGLFRIPGYIVGLQSKK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++  A P+       I + DA+     LT +  +   I+ A   G+  VA++N++H+   
Sbjct: 66  VVGTATPEIEEVTPIIFRCDAKNGYAPLTHEHCLPPLIDAAKKFGLAAVAIQNSHHFAAL 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
                + +E G IG+   + +  + P G K    GTNP+  + P     P+ ++DM+ S 
Sbjct: 126 WPEVEKMSEAGLIGLTTVSYLPWVAPAGGKTPIFGTNPMAFSWPRAGKNPV-VIDMATSS 184

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G + +    G ++P+  G  + G LT +   I K   +LP G  KGS +++++++++
Sbjct: 185 MAMGEVMIAARDGYEVPLGTGLSESGELTTDAAEIVKG-VLLPFGGHKGSALALMVELLS 243

Query: 238 TLLSDGASVAEVTQDNSDEYGIS---QIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             L       E  + +  E G +   Q  +AI  D ++ G     +  R        E+ 
Sbjct: 244 GPLVGETFSYETQERDKAEEGPARGGQFILAISPD-ILSGKNTSEQTDRFF------EKY 296

Query: 295 DENQAIRLPG 304
           D  +  R PG
Sbjct: 297 DAIEGARTPG 306


>UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria RepID=ALLD_ECOLI
          Length = 349

 Score = 87.0 bits (214), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 79/333 (23%), Positives = 138/333 (41%), Gaps = 12/333 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L       L   G+  E A   AE+       G++SHG  R   + +++  G 
Sbjct: 1   MKISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPK-RITSLGAIEQ-WDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWM 118
              + +P+ R+   G       A  + G + AK  M+ AI+ A  +G+ +V +    H  
Sbjct: 61  T--NREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSG 118

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMS 176
               +  QAA  G+IGI    S  ++ P+G  E   GTNPL  A P     I   DM+ +
Sbjct: 119 AISYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATT 178

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
           + ++G +   R     +P     D  G  T +P  +     +LP    KG G+ +++D++
Sbjct: 179 VQAWGKVLDARSRNMSIPDTWAVDKNGVPTTDPFAVHA---LLPAAGPKGYGLMMMIDVL 235

Query: 237 ATL---LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           + +   L  G  V+ +  D      + Q+ I I  +           L + M  + +   
Sbjct: 236 SGVLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMRELNAITP 295

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVW 326
           A     +  PG +      +    GI + D ++
Sbjct: 296 APGFNQVYYPGQDQDIKQRKAAVEGIEIVDDIY 328


>UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_DROVI
          Length = 520

 Score = 86.3 bits (212), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 85/330 (25%), Positives = 140/330 (42%), Gaps = 16/330 (4%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           V  +  V  + A   A+        G  S G++R P     L N  + P  QPK ++   
Sbjct: 179 VFAAMDVPDDAASEMADALIAADYMGQRSMGIHRLPAIAADLLNLTVDPRMQPKLVSERD 238

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           A+   D Q + G + A   MD AI  A + GIG VA R +N       Y  QA     IG
Sbjct: 239 ALALVDGQNAPGPVVANFCMDLAIRKARNQGIGYVAARRSNTIGMASWYTCQALSHRMIG 298

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT-MVDMSMSMFSYGMLEVNRLAG--R 191
           IC +N   ++ P G  E  +G N +  A  S     ++D+ MS +    L++    G  R
Sbjct: 299 ICMSNGPPILVPCGGSEPLLGGNSIACAAGSKQEQFLMDLGMSAYPIEQLQLEYSNGYLR 358

Query: 192 QLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIATLLSDGASVA--- 247
           QLP     D  G  T       + +R+ P     K  G++ ++D++  +++ GAS A   
Sbjct: 359 QLPDYLALDSSGKPTNCAAEALRAQRLRPFTPEHKAFGLAAMVDILCGVMT-GASYATHI 417

Query: 248 ---EVTQDNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSAERADENQAIRLP 303
               +   ++    + Q++IAI+  +  +    R A   +++  V      D  Q   +P
Sbjct: 418 RHRSLFSSDNKLADLGQVYIAIDPMRFCVSFEERLADFHQLLRNVIP---CDPMQPPLIP 474

Query: 304 G-HEFTTLLAENRRNGITVDDSVWAKIQAL 332
           G  E   +   + + G+ +  S  + IQ L
Sbjct: 475 GDKELQHMQMVDDQGGLMLSPSTLSVIQEL 504


>UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobiales
           RepID=B1M8T8_METRJ
          Length = 329

 Score = 85.9 bits (211), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 82/341 (24%), Positives = 142/341 (41%), Gaps = 26/341 (7%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T  +  A     L+  G     A + A         G+  HG++R   +  Q+  G ++
Sbjct: 4   LTLSEAGALAADALVRCGTAEAAARSVARALVGAEADGLKGHGLSRVAPYAAQVRAGKVV 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE----LAADHGIGLVALRNANHWM 118
            DA P        +   DA        A   +D A+E    LA   G+    +R ++H  
Sbjct: 64  GDAVPLASRPRPGLLAIDAAHGF----AYPAIDLALEALPGLARQQGVAAAGIRRSHHCG 119

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSM 175
             G    + AE+G + + + N+ A M PWG ++   GTNPL  A P     PI +VD+++
Sbjct: 120 AAGRPVERLAEQGCVALLFANTPAAMAPWGGRQAVFGTNPLAFACPLPGGAPI-VVDLAL 178

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           S  +   +      G  +P     D +G  T + G    +  ++P+G  KG+ +++++++
Sbjct: 179 SKVARANIVGAARRGEPIPEGWALDADGRPTTDAGA-ALDGTMVPLGDAKGTALALMVEL 237

Query: 236 IATLLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSA 291
           +A  L       E +       D  G  Q+ + ++   L  D P R A L   +     A
Sbjct: 238 LAAGLVGARFAGEASSFLDAAGDPPGTGQLILVLDAAALSPDAPERFAALAGTIAAQDGA 297

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                    RLPG     L       G+ V +++ A+I+AL
Sbjct: 298 ---------RLPGSRRLGLRRRAAEAGLDVAEALVAEIRAL 329


>UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lipophiloflavum DSM
           44291 RepID=C0XQZ5_9CORY
          Length = 312

 Score = 85.9 bits (211), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 84/332 (25%), Positives = 147/332 (44%), Gaps = 24/332 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  + ++  F   L + G+  E A++ A +F     +G  SHG      ++  L+N  
Sbjct: 1   MKLGIDTVRTTFFDALRAHGMSEEQAESSAGVFLDAELAGKPSHGAFHLLTYLSALDNRS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I   A P   T+ G++   DA   +     +K  D+ +++A  +G+ + A+R        
Sbjct: 61  INGQANPT-ATARGSVLAIDADDGLAQFALEKHRDQLLDIARTNGVAVAAVRKT---FTT 116

Query: 121 GSYGWQA---AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSM 177
           G  GW A   A  G I +  TNS A++    + E  +GTNP+   IP     +VD + + 
Sbjct: 117 GELGWYARFFARHGLISLTTTNSPALVTLNASGERVVGTNPVTFGIPEA--MVVDQAATP 174

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++  +  +   G  LP     D  G  T +  V      +LP G  +G  +++V +M+A
Sbjct: 175 AAFMRVRQHAERGEPLPQGWAVDAAGRPTDDASVAVDEGALLPNGGHRGGNLALVFEMLA 234

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L   G   ++   +  DE     +F A+ +D    G     +LQ  +     A  ADE+
Sbjct: 235 MLA--GRESSKSAANRGDEPPRVGLF-ALVIDPDFFGAGTLGRLQAHL-----ATLADEH 286

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           + + +PG       AE     + +DD+ W K+
Sbjct: 287 E-VYIPGRT-RPAPAE-----LDIDDATWEKL 311


>UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VRA6_MARMS
          Length = 349

 Score = 85.9 bits (211), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 78/345 (22%), Positives = 154/345 (44%), Gaps = 25/345 (7%)

Query: 1   MKVTF---EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE 57
           MK T+    +LK+   ++L   G+  + A   AE+  ++ E G  +HG++  P +I +L+
Sbjct: 1   MKFTYFNRNELKSLGTKLLSQYGMPDDRASITAELLIQSDELGFTTHGLSLIPYYIPELQ 60

Query: 58  NGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHW 117
            G +        +   G+   W+AQ   G     K MD A     +HG+   ++  A+H 
Sbjct: 61  AGKMQEADDVVVVNDTGSTFVWNAQYLPGIWMMNKAMDEAFSRVKEHGVVTASINRAHHI 120

Query: 118 MRGGSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPST--PITMVDM 173
               +Y   A +K  I I  T+  A  ++ P+G  +  +  NP  +  P+   P+ ++D 
Sbjct: 121 GCLSTYVKLATDKNLICIVSTSDPAGKLVAPFGGIDPVLTPNPWAIGYPTNGDPV-IIDT 179

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGM 229
             S+ ++  +  +   G  +P     D  GN T +  VI     ILP+G      +G   
Sbjct: 180 VTSICTFSKVREHLNTGLPMPYPMLQDKNGNETTDATVINDGGAILPIGGTDYGHRGYCF 239

Query: 230 SIVLDMIATLLSDGASVAEVTQDNSDEYGISQI----FIAIEVDKLIDGPTRDAKLQRIM 285
           SI+++M+   LS      +V++   + Y I  I    F  +E  K         ++ ++ 
Sbjct: 240 SIMVEMLTQGLSGHGRADDVSRWGGNVY-IQLIDPEAFAGLEAFK--------EQMDKLT 290

Query: 286 DYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +   ++   +E + +R+PG    +   +++  GI ++D    +++
Sbjct: 291 ELCLASRPREEGKPVRVPGQFGLSCAKQSKTQGIRLNDETLDRLK 335


>UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YHD0_MOBAS
          Length = 348

 Score = 85.9 bits (211), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 78/339 (23%), Positives = 149/339 (43%), Gaps = 16/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +  L    +  L + G+D+  A+  AE        G  +HG+   PR++++LE G +
Sbjct: 4   RYDYRALIGYAHDALAASGLDAGHAEIVAETLVEGDLLGHSTHGLALLPRYLRELEAGHM 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  +   GA   W      G +  ++ +    + A D G+  VA+  ++H     
Sbjct: 64  TKAGEPTIVRDHGASAAWGGNYLPGPVLVRRALALCTDRARDAGVATVAIGQSHHVACLA 123

Query: 122 SYGWQAAEKGYIGICWTNS--IAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSM 177
           +Y     ++G   I  ++S   A + P+GA E     NP+    P+   P+ +VD+S S+
Sbjct: 124 AYLKAVTDEGMAAIIASSSPATASVAPFGAVEGIYSPNPIAAGWPTGGDPV-LVDISASI 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYWKGSGMSIVLDM 235
            +  ++      GR+LP       +G  + +P ++       +LP+G  +       L +
Sbjct: 183 TTNSLVSERVEEGRRLPGAWMIGPDGTASDDPALLTARPAGALLPLGGTEYGHKGFALGL 242

Query: 236 IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA- 294
           I  +L+ G +      D  D++G S +F+ + VD    G    A  +R   ++  A R  
Sbjct: 243 IVEMLTAGLA-GHGRADAPDQWGAS-VFVMV-VDPEHHG--GRAAFERQTGFMAGAARGA 297

Query: 295 ---DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
              D   A+RLPG     L  +   +G+ + D + A+++
Sbjct: 298 KVPDGASAVRLPGERALRLRRQQMADGVVLSDELLARLR 336


>UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=1
           Tax=Streptomyces ghanaensis ATCC 14672
           RepID=UPI0001AF065C
          Length = 319

 Score = 85.5 bits (210), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 81/314 (25%), Positives = 139/314 (44%), Gaps = 14/314 (4%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           GV  +  D   E +      G  SHG+ +F  F  Q  +  + P   P+     GA+   
Sbjct: 9   GVPGKGTDRVVEHYLDGELRGKPSHGLAKFA-FESQFFSQRVGP---PRIKHERGAMAVV 64

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           D +R +G L+A   +  A   A   G+G+V + N   +    S+  Q AE+G +G+    
Sbjct: 65  DGRREVGPLSADFAVRLAARKARRLGVGVVGMVNCQRYGILASWSEQIAERGLVGLVANT 124

Query: 140 SIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYGMLEVNRLAGRQLPVDGG 198
           S       GA+   +G NP+  A P++  T+  DMS ++   G+L   R +G  LP D  
Sbjct: 125 SRPEATVHGARTPFLGVNPVSFAFPTSDSTVSADMSTTLAPMGVLWEARRSGSPLPPDCF 184

Query: 199 FDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYG 258
            D+ G  T +P   +  R  +  G  +G  +S+++ ++   L  G  + E        + 
Sbjct: 185 VDEHGAFTDDP---DAARAAMVFGEHRGFALSLLIQILTGSLF-GFPMGERVDST---WT 237

Query: 259 ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNG 318
               FIA++      G         + D V  A    E  ++R+PG E     A  R+ G
Sbjct: 238 TGYTFIALDPTFAGQGEEHLVANASLTDAVRQAA-TREGGSVRVPGQEGKDRAARARKTG 296

Query: 319 -ITVDDSVWAKIQA 331
            +T+D++++ ++QA
Sbjct: 297 RLTLDEALYKRLQA 310


>UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9XTB4_CAEEL
          Length = 400

 Score = 85.1 bits (209), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 62/245 (25%), Positives = 111/245 (45%), Gaps = 10/245 (4%)

Query: 40  GVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIE 99
           G YSHG+NR   +++ +E      D +P  +         D    +G +     MD AIE
Sbjct: 86  GHYSHGLNRLDMYVRDIEQNVCKGDGEPIILKEKAGTAWVDGNNLLGPVVGNFCMDLAIE 145

Query: 100 LAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL 159
            A + GIG V  + +NH+   G Y  +A +KG +G+  TN+  +  P  +    +GTNP+
Sbjct: 146 KAKNAGIGWVVAKGSNHYGIAGWYALRAMKKGMLGMSMTNTSPISFPTRSAVPALGTNPI 205

Query: 160 IVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI----- 212
            +A P T     ++DM+ +  + G +E+       +P+  G  + G  T +P  +     
Sbjct: 206 SLAAPGTGDDSFVLDMASTTVAIGKVELAARKENPVPLSWGVGEGGKETTDPTKVLYGGG 265

Query: 213 -EKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVD 269
                 +   G +KG G+S ++++   +L+       V +      E  + Q F+AI+ +
Sbjct: 266 LLPLGGVEVSGGYKGYGLSSMIEIFCGILAGAHWGPHVRKWMSTKSEADLGQCFVAIDPE 325

Query: 270 KLIDG 274
               G
Sbjct: 326 AFAPG 330


>UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacteriales
           RepID=Q11YA5_CYTH3
          Length = 381

 Score = 84.7 bits (208), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 81/319 (25%), Positives = 135/319 (42%), Gaps = 23/319 (7%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPD 64
           ++ L A    V ++ G   E A     +       GV SHGV R   +++  E G I   
Sbjct: 29  YKDLFAFTKNVFLAMGCPQEDAQVATTVLLSADLRGVDSHGVARLTGYVRLWEAGRINAK 88

Query: 65  AQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
              + +    +    D    +G + A   M  AI+ A   G G V+++N+NH+   G + 
Sbjct: 89  PNVRIVHETPSTATVDGDGGLGLVVAPIAMQIAIDKAKQVGSGWVSVKNSNHYGIAGYHA 148

Query: 125 WQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGM 182
             A E   IGI  TN+  ++ P  + +  +GTNP+ VAIP+   P  + D + +  + G 
Sbjct: 149 MMALEHDMIGISMTNASPLVAPTNSLKRLLGTNPIAVAIPAKNEPPMVADFATTTAANGK 208

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLDMI 236
           LE+ +      P+    D  G  T     ++    +LP+      G  KG  +  ++D+ 
Sbjct: 209 LEILQRKNLDAPLGWIQDKNGVTTPNAHELKDGGALLPLGGDREHGSHKGYCLGSIVDIF 268

Query: 237 ATLLSDG---------ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           + +LS            S   V  D   E GI   F A+ VD     P  D K   + ++
Sbjct: 269 SAVLSGANYGPWVPPFVSFLPVPSDPVGE-GIGHFFGAMRVDAF--RPADDFK-THMDNW 324

Query: 288 VTSAERAD--ENQAIRLPG 304
           +T+   A   E + + +PG
Sbjct: 325 ITTFRNAPAVEGEKVLIPG 343


>UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=8
           Tax=Sulfolobaceae RepID=A4YFT2_METS5
          Length = 328

 Score = 84.3 bits (207), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 83/333 (24%), Positives = 146/333 (43%), Gaps = 26/333 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V+ E+LK+    +L  R V  E ++  A+        G  SHGV R    ++ +E G 
Sbjct: 7   MNVSAEELKSIIVEILNEREV--EGSEVIADHMVEAELRGHSSHGVQRLIPLVKGVELGT 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   +         D + S+G +    + ++ I+   D    ++A++NA+H    
Sbjct: 65  ISRRLQYDVLKKERGSMWIDGKHSVGIV----LWNQLIQHEFDEPSSVIAVKNASHIGFL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           G Y  + A +GY+GI + N+   +   G     + T PL + IP  P  ++DM++S  S 
Sbjct: 121 GYYTDKLATRGYVGIMFGNAEPAVVLPGTSRKLLSTTPLSIGIPHAPPIVLDMALSSTSR 180

Query: 181 G-MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           G +LE  R  G  +P     D EG  T +P +  +   ILP+G  +G  + +VL+++ + 
Sbjct: 181 GKILEAQR-KGEPIPEGWAVDSEGKPTTDPELALRG-GILPIGGIRGFYLMLVLEILTSF 238

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           +S  A    V    + E   ++  I I ++                 + +  E+ DE + 
Sbjct: 239 ISGSAMGPNVKGVLNTENPPNKGEILIVINPFY--------------FASYTEQIDEIRK 284

Query: 300 I---RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +     PG     L A     GI +D  +W+ +
Sbjct: 285 LLGMEFPGEHGLQLKARRLTEGIPIDAQLWSTL 317


>UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11JG3_MESSB
          Length = 375

 Score = 84.0 bits (206), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 73/344 (21%), Positives = 150/344 (43%), Gaps = 13/344 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M   + Q +     +L++ G+    A   A++       GV SHG++    +  +   G 
Sbjct: 1   MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A  K +         D    +G++      D AIE A   GI + ++RN++H+   
Sbjct: 61  LKMNADFKVVRETPVSVLIDGDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAV 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPST---PITMVDMSMS 176
           G +   AA  G I +  T++  + + P    E ++GT+PL  A PST   P  ++DM+ +
Sbjct: 121 GYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLSFAAPSTDENPF-LLDMATT 179

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG------YWKGSGM 229
             +YG +         +P+  G D  G  T +P  V  +   + P+G       +KG G+
Sbjct: 180 TVAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGL 239

Query: 230 SIVLDMIATLLSDGASVAEVTQDNSDE-YGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           S++++++++ LS    + +       + + I   ++A++     D    +  +      +
Sbjct: 240 SVMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAAL 299

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + +  +E   + + G     +  E  R G+ +   + AK+ A+
Sbjct: 300 RNTKPVEEGTPVMVAGDPQWKMAEERLREGVPIGKGLRAKLIAV 343


>UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME
          Length = 461

 Score = 83.6 bits (205), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 84/332 (25%), Positives = 142/332 (42%), Gaps = 18/332 (5%)

Query: 12  FNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT 71
           F+ + + +   SE ADA           G  S G++R P     L N  +  DA P  ++
Sbjct: 109 FSAMQVPKQAASEMADA----LIAADYMGQRSMGIHRLPSIAADLLNCTVAGDATPGIVS 164

Query: 72  SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKG 131
              AI   D   + G + A   MD A++ A + GIG V+ R++N       Y  QA E+ 
Sbjct: 165 EKKAIALVDGHNAPGPVVANFCMDLALQKAREVGIGWVSARSSNCIGFASWYACQALEQR 224

Query: 132 YIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLAG 190
            IG+C TN+   + P G  E  +G NP+  A        V D  M+  S   LE++   G
Sbjct: 225 MIGLCMTNAAPTLVPAGGIEPVLGENPIACAASGVHEQFVADFGMAACSVDELELSYCNG 284

Query: 191 --RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIATLLSDGASVA 247
             +Q+P     D  GN T       + +RI       KG G++  +D++  +++ GA  A
Sbjct: 285 WSKQVPKLVALDRNGNETTSTEEALRAQRIRAFQPEHKGFGLAAAVDILCGVMT-GARYA 343

Query: 248 E------VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                  V    +    + Q+++AI  D +   PT + +L      +  A  +   +   
Sbjct: 344 NQIQRRGVYSTENAPANLGQVYVAI--DPMRFCPTFEDRLADFHRLLRQAVPSKVGKPPM 401

Query: 302 LPG-HEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +PG  E   +   + + G+T+     + ++ L
Sbjct: 402 VPGDKELQHMKMVDEQGGLTMSSCTLSVLEEL 433


>UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5SZX1_ACIDE
          Length = 376

 Score = 83.6 bits (205), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 82/351 (23%), Positives = 153/351 (43%), Gaps = 24/351 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + T E L+A    +L + G+   TA   A +   T   GV SHG++   ++    + G +
Sbjct: 7   RFTAESLRAQTAAILQAWGMPETTAHTTAALMVETDLLGVESHGISMLAQYEAMRDGGRL 66

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+ +    A    D    +G+  + + M  A++ A   GI LV +RN++H+   G
Sbjct: 67  HLAASPRVLRDGPATALLDGDAGLGHAVSAQAMQLAVDKARALGIALVGVRNSHHFGAAG 126

Query: 122 SYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTPIT-----MVDMSM 175
            Y   A  +G IG+  +++  + + P  A E  +GTNP+  A P +  +     ++DM+ 
Sbjct: 127 VYARIAQRQGLIGLVTSSAQGILLVPTRAAEPVLGTNPIAFAAPVSQGSHNNAFVLDMAT 186

Query: 176 SMFSYGMLEVNRLAGRQLPVDGG--FDDEGNLTKEPGVI------EKNRRILPM------ 221
           +  +   ++V  L  R  PV  G   D +     EP         + +  + P+      
Sbjct: 187 TTAAANRVKVKAL--RSEPVPSGWVVDGQSQPVTEPEAARAQVFDQPDGGLTPLGGSSDG 244

Query: 222 GYWKGSGMSIVLDMIATLLSDGASVAEVTQDN--SDEYGISQIFIAIEVDKLIDGPTRDA 279
           G  KG G++++  ++   L+ GA      Q +   D   +   FIAI+     +    + 
Sbjct: 245 GSHKGYGLALLAQVLGGTLNGGAFAPLYRQSHGPGDPANVGHSFIAIDPRFFGEPGAFEH 304

Query: 280 KLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +L  I+D + +   A+  + + + G       AE  R GI +   +  +I+
Sbjct: 305 ELDAILDVLHATRPANPAEPVLVRGDPEAAQHAERARLGIPLPAPLLRQIR 355


>UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Verrucomicrobiae
           bacterium DG1235 RepID=B5JGV2_9BACT
          Length = 351

 Score = 83.2 bits (204), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 80/336 (23%), Positives = 151/336 (44%), Gaps = 28/336 (8%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L +   + L   G+  + A   A++       G  +HG+   P ++  LE+G +    
Sbjct: 13  ENLLSFAVKALTRAGLAEDRARVVADVLLDADLMGHSTHGLGLLPLYVGALEDGKMEVAG 72

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           +P  +   G+   WD +   G     + ++  +E   +H +  V ++ ++H     SY  
Sbjct: 73  EPVVLNDRGSTLAWDGRYLPGAWLTCRAIEEGLERLGEHPVVTVTIQKSHHIGSLASYPM 132

Query: 126 QAAEKGYIGI--CWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYG 181
           +A +KG + +  C   +  ++ P+G  +     NP+   IP++  P+ + D SMS  ++G
Sbjct: 133 RAIKKGAMMLLTCSDPNSELIAPFGGLDAVYSPNPIAAGIPTSGRPV-IFDTSMSTTAWG 191

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMG----YWKGSGMSIVLDM 235
           +    +  G +LP     D+EG  T +P V+  E +  ILP+G     +KG  + ++++ 
Sbjct: 192 VANRAKQQGERLPGKWMQDNEGKATDDPKVLDSEPSGTILPIGGADHGYKGFALGLLVEA 251

Query: 236 IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +   LS      E+ +     +G S     I+ D        DA  +R MDY+  A+R  
Sbjct: 252 LTCGLSGSGRADELGR-----WGCSTFIQLIDPDAF---GGSDA-FRREMDYL--AKRCH 300

Query: 296 ENQ------AIRLPGHEFTTLLAENRRNGITVDDSV 325
           +++      A+RLPG     L  E    G+ + + V
Sbjct: 301 DSRTRPGADAVRLPGERALALREEQVVAGLVLPEVV 336


>UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1WRH9_VEREI
          Length = 354

 Score = 82.8 bits (203), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 75/338 (22%), Positives = 153/338 (45%), Gaps = 24/338 (7%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +  +L+    ++L   G+    ADA A         G  +HG+     +++++  G +
Sbjct: 6   RFSAAELRQFSTQLLQKAGLPLAPADAVARTLVDGDLLGHDTHGLALLVPYVREVSKGAM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++   A   W+ +R  G     K +D  I  A + G   + + +++H     
Sbjct: 66  TTSGEPDVVSDRPAALVWNGRRLPGPWLVHKGIDALIARARELGTAALVIHHSHHIACLA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSM 177
           +Y  +A E+G++ +  ++  AV  + P+G        NP+   IP+  TP+ +VD+S S+
Sbjct: 126 AYLLRATEEGFLMVLSSSDPAVQSVAPFGGTRAVFTPNPIAAGIPTSGTPL-LVDISASI 184

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYW----KGSGMSI 231
            + GM      AGRQ   +   D +GN +++P V+  +    ILP+G      KG G+++
Sbjct: 185 TTNGMSNRLHKAGRQFEEEWMLDAQGNPSRDPAVLAADPPGSILPLGGLSAGHKGFGLAV 244

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++ +   LS          D    +G + +F+++       G    A  +R MD++  A
Sbjct: 245 LIEALTGGLSGFGRA-----DPPTGWG-ATVFMSLYDPAAFGG---QAAFRRQMDHIAEA 295

Query: 292 ERADENQA----IRLPGHEFTTLLAENRRNGITVDDSV 325
            R++  +     +R+PG       A+    G+ +  ++
Sbjct: 296 CRSNPPRPGVGQVRMPGDRGMARRAQQLEQGVALHPTI 333


>UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2 Tax=Idiomarina
           RepID=Q5QTW6_IDILO
          Length = 356

 Score = 82.4 bits (202), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 78/343 (22%), Positives = 141/343 (41%), Gaps = 21/343 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++  + +L       L   G   E A   +         G  +HG+ R     Q L +G 
Sbjct: 6   VRFDYSELSDWARTCLTEAGASGEVARNVSYYLLEGDLLGFSTHGLIRLLNNCQWLRDGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            +   QP  +    A+  WDAQ   G     + +D A ++A   G G V +R + H    
Sbjct: 66  SLAKGQPVVLRERAAVANWDAQFLPGPYVVPQAIDAACKMAKQAGTGTVVVRRSQHVAAL 125

Query: 121 GSYGWQAAEKGYIG--ICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMS 176
            +Y   A ++G +   +C T     + P+G KE     NP  V +PS+  P+ + D+S S
Sbjct: 126 AAYLSIATDQGLVVSLMCSTPGQRAVAPFGGKEAVFSPNPFAVGVPSSNNPL-LFDISFS 184

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMG----YWKGSGMS 230
           M + G +   +  G +LP       +G  T +P          I P+G     +KG G++
Sbjct: 185 MTAAGKVRQAKANGTRLPYKALIKPDGEWTDDPLTFFESPGSSIAPLGGEQLGYKGYGLT 244

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +  ++ +  LS         +  SD+   + I++ + +D    G  +   LQ++ D +  
Sbjct: 245 LFSEIWSMALSQYGR-----RQGSDDGDANSIWVQV-IDPEAFG-EKQKFLQQVDDLLAD 297

Query: 291 AER---ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           + +   A   Q +R+PG        E  + G++   +    +Q
Sbjct: 298 SRKSAPAVPEQPVRIPGEGAQKRKREQLQQGVSYSSATLKVLQ 340


>UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella petrii
           DSM 12804 RepID=A9I3U5_BORPD
          Length = 351

 Score = 81.6 bits (200), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 71/335 (21%), Positives = 146/335 (43%), Gaps = 18/335 (5%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L       L++  VD+  A   A         G  +HG+   PR+++++  G      
Sbjct: 9   EALVQFAQHCLLAVDVDAPIAAVVARRVVDADLYGHATHGLALLPRYLKEISEGATQRRG 68

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           + +RI+  GA   WDA    G+    + +  A++     G+  +A+R++ H      Y  
Sbjct: 69  EIRRISEKGACLLWDAAMLPGHWVLHQAIQAALQRVPAQGMVSIAVRHSQHIGALQVYLP 128

Query: 126 QAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYG 181
              + GY+ + W     V  + P+G  +  + + P+   IP+  TPI ++D + S+ S  
Sbjct: 129 DLTDAGYLCLLWATDTKVRSVAPFGGLDPVLTSEPIAAGIPTRGTPI-LIDTTTSLTSNS 187

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMG----YWKGSGMSIVLDM 235
            ++  +  G +LP       +G +T +PG +  +    ILP+G     +KG  M++++  
Sbjct: 188 FVKQVQARGERLPWPALLSADGRVTDDPGALATDPPGTILPLGGMDHGYKGYAMAMLVGA 247

Query: 236 IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           ++  LS    +  ++ + +  +    +   I+ D          ++Q + D   +A   D
Sbjct: 248 MSLGLS---GLGRLSGEKAQGF----LLQVIDPDAFAGRDIFLDEMQALADATRAARPID 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             + +R+PG          RR+G+ +   + A ++
Sbjct: 301 PARPVRVPGDAALARAERQRRHGVRLGADISAALE 335


>UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z6D1_9GAMM
          Length = 333

 Score = 81.3 bits (199), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 81/339 (23%), Positives = 151/339 (44%), Gaps = 22/339 (6%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + +++     L++ G   E A   A   A     G+ + G+     +++ L+ G + 
Sbjct: 4   LSLQAIESLCRESLLAVGASDEQAAIVAAEIAEAEAEGIRNVGLGYIHLYLKHLKVGKVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+AQP  + +  A    DA     +        R IE A + G+ ++A+  ++     G 
Sbjct: 64  PNAQPSVVKTSAASTVVDADFGFCHHAYMVGEQRLIETAREQGVAMLAIHQSS---SAGV 120

Query: 123 YGW---QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMS 176
            GW   + A++G + + + NS   +   G K    GTNP     P     P+ +VDM+ +
Sbjct: 121 LGWFVRRLAQQGLVSLMFANSSKAVAAHGGKVPFFGTNPFAFGAPRGTDEPL-VVDMATA 179

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             +   L      GR++      D +GN T +P    K  + LPMG  KG G+ +++D++
Sbjct: 180 STARVNLVKAAAEGREIEPGHAIDADGNPTTDPSAGLKGAQ-LPMGGPKGFGLGLMVDVL 238

Query: 237 ATLLSDGASVAEVTQDNSDEYG---ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           A +L+      E +   + + G   + Q  IAI+ +  +DG      L+ +   +T    
Sbjct: 239 AGVLTGSNCSYEASMFANIDGGPPNVGQTIIAIDPN-FLDG-NFTTHLETMFAALT---- 292

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             EN  +R+PG     L  ++  +G+ V  S+  +I  L
Sbjct: 293 --ENNDVRIPGERRAQLRVKHEADGVDVPQSLIDQITEL 329


>UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=1 Tax=Brucella ovis
           ATCC 25840 RepID=A5VTX8_BRUO2
          Length = 319

 Score = 80.9 bits (198), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 82/332 (24%), Positives = 141/332 (42%), Gaps = 46/332 (13%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T E+L A    +    G+++  A A A +          SHG+ R    ++ ++ G + 
Sbjct: 7   LTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKVK 66

Query: 63  PDAQPKRIT-SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           PDA P+ +     AI + DA+    N         A EL    G+ ++A R  +H     
Sbjct: 67  PDAVPELVAQEASAIVRVDAKGGFAN--------PAFEL----GVPVLAERARSH----- 109

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                    G  G+    S A + P G  +  +GTNP     P    P  + D + S+ +
Sbjct: 110 ---------GLAGLVMCLSYATVAPTGGSKPLLGTNPFAFGWPRRDNPPYVFDFATSVAA 160

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +E++R AG+QLP     D +G  T +P    +   +LP G  KGS +S +++++A +
Sbjct: 161 RGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEG-AMLPFGGHKGSAISTMIELLAGI 219

Query: 240 LSDGASVAEV-----TQDNSDEYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSAE 292
           +    +  EV     T   S  +G  ++ IA   +    G   D  A+ +   + +    
Sbjct: 220 MIGDRTSPEVLDFLGTTTLSPVHG--ELIIAFSPEAFAAGRPGDPFARAEAFFEAIV--- 274

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDS 324
                Q  RLP     T  A ++  GIT++ +
Sbjct: 275 ----GQGARLPSQRRFTARAASQSEGITLNKA 302


>UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1 Tax=Sulfolobus
           tokodaii RepID=Q96YT3_SULTO
          Length = 318

 Score = 80.5 bits (197), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 70/251 (27%), Positives = 117/251 (46%), Gaps = 13/251 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  ++ ++    +L  RGV  E     A+ F      G YSHG+ R    ++ ++ G 
Sbjct: 1   MKIKVKEAESLVESILKKRGV--ENPSIIAKHFVEAELRGHYSHGLQRVIPLVKGIDLGT 58

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   I        +DA  SIG L    + +   E        L+A+RN++H    
Sbjct: 59  IRKTVQLTEIKREDNAVLYDANYSIGILVWHYLTESPKE-------TLIAVRNSSHIGFL 111

Query: 121 GSYGWQAAEK-GYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMF 178
           G Y  + A + G   I   N+  AV+ P  AK+  I T P+ +AIP   I ++DMS+S  
Sbjct: 112 GYYTRRIAMRLGKPAIMIGNAEPAVVKPGTAKKI-ISTTPISIAIPCEKIVVLDMSLSPI 170

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +   +  G ++P     + +G +T +P    +   +LP+G  KG  + I L+++ +
Sbjct: 171 ARGKIIEAKRKGEKIPYGVTVNKDGEITTDPDEALQG-GLLPIGGMKGFFLMITLELLVS 229

Query: 239 LLSDGASVAEV 249
            L+  A   EV
Sbjct: 230 FLTGSALATEV 240


>UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11CF6_MESSB
          Length = 358

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 79/329 (24%), Positives = 145/329 (44%), Gaps = 15/329 (4%)

Query: 11  AFNRVLISR-GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKR 69
           A  R L  R G+ +E A   A +       G  +HG+   P +++ +E G +  D  P+ 
Sbjct: 19  ALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGMTLDGDPEV 78

Query: 70  ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAE 129
           +  LGA   WD ++  G    ++    A+  A   G+G VA++ ++H    G+Y   A  
Sbjct: 79  LNDLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLGAYLEPAVA 138

Query: 130 KGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEV 185
            G + +        + + P+G     + +NP+    PS   PI ++DMS ++ + G +  
Sbjct: 139 AGCMVLVTLTDPGHSSVAPFGGVTPVLTSNPIAFGAPSPDRPI-LIDMSTALMTNGGVAA 197

Query: 186 NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR--RILPMGYWKGSGMSIVLDMIATLLSDG 243
            R  G  LP     D +G  + +P +I  +    ILP+G  +       + +I  LL+  
Sbjct: 198 YRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEAGHKGFSIGLIVELLT-- 255

Query: 244 ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ--RIMDYVT-SAERADENQAI 300
             ++   +   D+   + +F+ + VD    G   D + Q   ++D    SA R   N  +
Sbjct: 256 GCLSGRGRAEGDDGWSAAVFVLV-VDPAAFGGEEDFQRQVAALVDLCHGSALRPGFNH-V 313

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            LPG +  +     RR+G+ +   + A +
Sbjct: 314 DLPGAQAFSRREGQRRDGVLLSPGIVAGL 342


>UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=4
           Tax=Alphaproteobacteria RepID=A8LPS4_DINSH
          Length = 339

 Score = 79.3 bits (194), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 73/319 (22%), Positives = 137/319 (42%), Gaps = 26/319 (8%)

Query: 14  RVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ-----PK 68
           R   + GV    A + A+        G   HG +R   ++ Q  +G I+  A+     P 
Sbjct: 20  RAFTANGVPEGAARSTADALVAAEAEGQVGHGFSRLEDYVAQARSGKIVAGAEVTITRPA 79

Query: 69  RITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAA 128
             T L      DA         ++ +D  I +A + G   +A+  ++H      +  +AA
Sbjct: 80  PTTLL-----VDAGHGFAYPALERAIDEGIAVARELGTAAIAVTRSHHCGALSIHVERAA 134

Query: 129 EKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEV 185
           + G + +   N+ A + PWG K    GTNP+  A P   S P+ ++D+S+S  + G +  
Sbjct: 135 KAGLVAMMVVNAPAAIAPWGGKTPLFGTNPIAFATPRAGSAPL-VIDLSLSKVARGKVMN 193

Query: 186 NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
            + AG+ +P     D  GN T +         ++P+G  KG+ +++++++++ +++  A 
Sbjct: 194 AKKAGKPIPEGWALDAAGNPTTD-AEAALGGTMVPIGEAKGTALALMVEILSAVMTGAAL 252

Query: 246 VAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
             E       +    G+ Q        +  +  T  A+L  ++  + + E A      RL
Sbjct: 253 STEAGSFFSADGPPPGVGQFLTLWRPPEGAEAFT--ARLAPLLAQIETMEGA------RL 304

Query: 303 PGHEFTTLLAENRRNGITV 321
           PG      L   + +GI V
Sbjct: 305 PGTRRLAALNAAQAHGIAV 323


>UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=cellular organisms
           RepID=Y1252_PSEAE
          Length = 334

 Score = 78.2 bits (191), Expect = 4e-13,   Method: Compositional matrix adjust.
 Identities = 74/344 (21%), Positives = 147/344 (42%), Gaps = 25/344 (7%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++++    R+L           A A+           SHG+ R    I  L+ G 
Sbjct: 2   IRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGK 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA+P+       + + DA         +  +   +E A   GI  +A+    H+   
Sbjct: 62  VSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHF--- 118

Query: 121 GSYGW----QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMS 174
            S  W       E G + +  T S A + P G ++   GTNP+    P    P  + D +
Sbjct: 119 -SALWVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFA 177

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLD 234
            S  + G ++++  AG+ +P+  G D++G  T +     +   +L  G  KGS ++ +++
Sbjct: 178 TSAVARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALRG-AMLTFGGHKGSALAAMVE 236

Query: 235 MIA-TLLSDGASVAEVTQDN---SDEYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYV 288
           ++A  L+ D  S   +  D    S  YG  ++ IAI+  +++     +  A+ + + + +
Sbjct: 237 LLAGPLIGDLTSAESLAYDEGSRSSPYG-GELLIAIDPRRMLGASAEEHLARAETLFEGI 295

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                    Q  RLP          + R+G+T+ +++  ++ AL
Sbjct: 296 V-------EQGARLPSQRRFEARERSARDGVTIPEALHRELLAL 332


>UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaproteobacteria
           RepID=A6UGA2_SINMW
          Length = 345

 Score = 77.4 bits (189), Expect = 7e-13,   Method: Compositional matrix adjust.
 Identities = 81/330 (24%), Positives = 141/330 (42%), Gaps = 32/330 (9%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E+++A F +     G++   A A A +          SHG+ R    ++ ++ G + PDA
Sbjct: 14  ERVEAIFRK----GGLNVVQAGALARVIVAGERDACKSHGIYRIEGALRTVKAGKVKPDA 69

Query: 66  QPKRITS-LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
            P+ I     AI + +A     N   +  +    E A   GI  +A+ +  H+    S  
Sbjct: 70  IPEIIAQEASAIVKVNAGGGFANPAFELGLPVLAERARTQGIAALAINDCTHF----SAL 125

Query: 125 WQAAE----KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
           W  AE    +G  G+    S A + P G  +  +GTNP     P    P  + D + S+ 
Sbjct: 126 WPEAEALTGEGLAGLVMCPSYATVAPTGGNKPLLGTNPFAFGWPRAGRPPYVFDFATSVA 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +E++R AG+ LP     D +GN T +P        +LP G  KGS +  +++++A 
Sbjct: 186 ARGEIELHRRAGKALPDGWAIDAKGNPTTDPEAALAG-AMLPFGGHKGSAIGTMIELLAG 244

Query: 239 LLSDGASVAEV-----TQDNSDEYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSA 291
           ++    +  EV     T   +  +G  ++ IA   +    G   D  A+ + + + +   
Sbjct: 245 IMIGDLTSPEVLDYLGTTTLAPFHG--ELIIAFSPEAFAAGRPGDPFARAEMLFEAIV-- 300

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITV 321
                 Q  RLP        A++   GIT+
Sbjct: 301 -----GQGARLPSQRRFAARAKSEAEGITL 325


>UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria RepID=A8I4Z4_AZOC5
          Length = 376

 Score = 75.9 bits (185), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 59/191 (30%), Positives = 92/191 (48%), Gaps = 2/191 (1%)

Query: 25  TADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRS 84
           T DA        +  GV SHGV     ++  LE G +        +   GA+   DA  +
Sbjct: 48  TVDAATRAMMHASRLGVDSHGVRLLNHYVSALEGGRVARAPHLTYVRETGAVATLDAGAA 107

Query: 85  IGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVM 144
            G L A   MDRA++LA+  GIG VA+RN++H+   G++   AAE+G++G+ + NS + +
Sbjct: 108 HGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAFCNSDSFV 167

Query: 145 PPWGAKECRIGTNPLIVAIPSTPIT--MVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDE 202
                 E   GTNP+  A P       + DM+ S   +  + + R     LP D   D E
Sbjct: 168 RLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAE 227

Query: 203 GNLTKEPGVIE 213
           G  T++   ++
Sbjct: 228 GVDTQDANAVD 238


>UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11B93_MESSB
          Length = 354

 Score = 75.5 bits (184), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 70/307 (22%), Positives = 129/307 (42%), Gaps = 16/307 (5%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           LK     +L +  V ++ A+  A++       G  +HG+ + P ++  L  G + P    
Sbjct: 12  LKDYARNLLKALDVQTDIAEVVADVLVEGDLLGHSTHGLAQLPSYLDNLAKGQMKPSGTY 71

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             ++   A   WD Q   G    +     A   A   G G V +R ++H     +Y    
Sbjct: 72  SVVSDFPAATTWDGQWLPGPWLTRTACIEAKTRARKFGTGTVVIRRSHHIACLAAYLEPL 131

Query: 128 AEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGML 183
             +G++ I  ++  AV  + P G     +  NP+ V IP+   PI ++D+SMS+ + GM 
Sbjct: 132 TAEGFVCIIQSSDPAVKAVAPHGGTRPFLTPNPVAVGIPTKGDPI-LIDVSMSIATVGMA 190

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR--ILPMG----YWKGSGMSIVLDMIA 237
                +G + P     D +G+ T +P VI+ + +  ++ +G      KG G++++++ + 
Sbjct: 191 RRLIASGERAPFPWLLDGDGHPTDDPNVIDADPKGSLMLLGGIEAGHKGFGLALMVEALT 250

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                G        D    +G S     ++ D          ++  I D   S    D N
Sbjct: 251 -----GGLGGHGRADKPTNWGASVFVQVLDPDAFGGKEALLREMSFIADECVSGPSRDIN 305

Query: 298 QAIRLPG 304
             +R+PG
Sbjct: 306 NPVRMPG 312


>UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus RepID=C1XHL2_MEIRU
          Length = 332

 Score = 75.1 bits (183), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 70/335 (20%), Positives = 144/335 (42%), Gaps = 16/335 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V +  LK A +      G+  + A+A  E+       G   HG+ R  ++  QL+ G 
Sbjct: 1   MRVPYPVLKQAVSSHFQGLGLAPDHAEAFTEVILEAELEGNLGHGLTRIAQYTAQLQAGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  Q +   +   +    A  + G +     +     +A + G   +A+R A H    
Sbjct: 61  LNPRPQMRLERTKPGVAVLHADGAPGPVAGLFAVQALAPMAREQGSAALAVRGAGHSGVL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
            +Y  + A++G + + + N+    PP  A    +GTNP+ +  P+ P   ++D S+S+ +
Sbjct: 121 SAYVGRLAQEGLVALAFANT----PPAIAPGPVLGTNPIALGAPAEPQPVIIDTSISVVA 176

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            G +      G  +P     D EG  T +    +E +  +LP+G  KG  ++++++++A 
Sbjct: 177 RGKIIAAAKKGEPIPPGWALDKEGRPTTDAKAALEGS--LLPIGEGKGFALAVLVEILAG 234

Query: 239 LLSDGASVAEVTQD-NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L+      E+               + +  D    GP    ++ ++++ + +A      
Sbjct: 235 ALAGDVLSPELPLPWMPPAQAAKPGLLLLAFDPAAFGPGYRGRVAQLIEALKAAGG---- 290

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              R+PG     L  +    G+ V+ ++ A++  L
Sbjct: 291 ---RIPGARRAALREKALAEGLEVNQTLQAELGTL 322


>UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS
          Length = 384

 Score = 74.7 bits (182), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 69/307 (22%), Positives = 125/307 (40%), Gaps = 7/307 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  E+ +      L   GV        +E        G+Y  G+++   ++  L +    
Sbjct: 35  VHVEEARRFIRDCLKRIGVPELKLRCVSEFLVAADYRGIYGSGLSQLDIYLNDLLHRRAN 94

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+ I    A    +   ++G +     M  A+E A + G+G V    +N+      
Sbjct: 95  MDAEPEIIRETVATAHVNGNDALGVIVGNFCMSLALEKAKNVGVGFVVANRSNNLGIASW 154

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFSYG 181
           Y  QA ++ Y G+  +N   +M P  +    IG N L   +       M+DM  SM   G
Sbjct: 155 YALQALDQDYAGLVMSNGAPIMVPPRSSVASIGANCLAFGVKGRNSYFMLDMVSSMKDIG 214

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +E        +P     D+ G  T  P +  +N R+   G  KG  ++ ++D++  +LS
Sbjct: 215 SIEWALTKHEYIPHLWAADERGYSTCFPMLALRNPRLTCAGASKGYCLAAMIDLLCGVLS 274

Query: 242 DGASVAEVTQDNSDEY----GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                 ++    S+       + QIFI I+ D  +  P    +L    + + ++  A   
Sbjct: 275 GANFSTQIPPWRSNVKRLCPNLGQIFIVIDPDFFL--PDFMDRLDDFTECIKNSTPASLA 332

Query: 298 QAIRLPG 304
           + I++PG
Sbjct: 333 KPIQMPG 339


>UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NGA8_DROWI
          Length = 502

 Score = 74.3 bits (181), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 68/258 (26%), Positives = 113/258 (43%), Gaps = 12/258 (4%)

Query: 21  VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWD 80
           V  + A   A+        G  S G++R P     L N  +   A+P+      A+   +
Sbjct: 162 VPQDAASDMADALVAADYMGHRSMGIHRLPAIAADLLNCTVSAIAKPEIQKENDALALVN 221

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNS 140
              + G + A   MD AI+ A   GIG V  R +N       Y  QA EK  IG+C +N+
Sbjct: 222 GSNAPGPVVATFCMDLAIQKAQQVGIGWVVARKSNCIGMASWYACQAMEKRLIGLCMSNA 281

Query: 141 IAVMPPWGAKECRIGTNPL-IVAIPSTPITMVDMSMSMFSYGMLEVNRLAG--RQLPVDG 197
              + P G  E  +G NP+  VA       +VD   S  S   LE++   G  ++LP   
Sbjct: 282 APTLVPSGGIEPILGENPIACVAAGEHEQFLVDFGQSSCSVDQLELSYCNGKLKELPPAL 341

Query: 198 GFDDEGNL-TKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIATLLSDGASVAE------V 249
             ++ G   T +     + +R  P    +KG G++ ++D++  ++S GA  A       +
Sbjct: 342 ALNESGEQDTNDVAEALRAQRFYPFRPAYKGFGLAAMVDILCGVMS-GAQYANQLRKRGI 400

Query: 250 TQDNSDEYGISQIFIAIE 267
               +  Y + Q+++AI+
Sbjct: 401 FSTENKPYDLGQLYVAID 418


>UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKP7_VARPS
          Length = 355

 Score = 73.6 bits (179), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 79/348 (22%), Positives = 143/348 (41%), Gaps = 42/348 (12%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E LK     +L   G+ +   D+ A         G  +HG+     ++++LE+G +  + 
Sbjct: 12  EALKDYAGALLQKAGLAAPMTDSVARTLVEGDLLGHDTHGLALLAGYVKELESGGMTREG 71

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
            P+ ++   A   WD +R  G     + MD  +  A + G   + +R ++H      Y  
Sbjct: 72  APEVLSDRPAAVLWDGKRLPGPWLMDQGMDLLVPRARELGTASLVIRRSHHIACLAVYML 131

Query: 126 QAAEKGYIGI--CWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGM 182
           +A E+  + +  C   + A + P+G  +     NPL +  P S    MVD+S S+ + GM
Sbjct: 132 RALEEDMLMLLACSDPNTASVAPFGGTQAVFTPNPLAMGFPLSQGGVMVDISASITTNGM 191

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYW----KGSGMSIVLDMI 236
               R AG     +   D  G  +  P V+  +    +LP+G      KG GM+++++ +
Sbjct: 192 SNRKRAAGETFAEEWLIDAAGKPSNNPQVLFDQPPGTLLPVGGLSHGHKGYGMALLVETL 251

Query: 237 ATLLSD----------GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
              L+           GA+V  VT  +   +G  + F+                  R MD
Sbjct: 252 TAGLAGHGRADPPEGWGATV-HVTLHDLHAFGGKEAFL------------------RQMD 292

Query: 287 YVTSAER----ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +V +  R     D  + +R+PG           +NG+ +  S+   +Q
Sbjct: 293 HVAAQCRNNRPIDPARPVRMPGEGGLKRRDAQSKNGVRLHPSIARSLQ 340


>UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=1 Tax=Ruegeria
           pomeroyi RepID=Q5LT11_SILPO
          Length = 350

 Score = 72.4 bits (176), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 79/320 (24%), Positives = 136/320 (42%), Gaps = 23/320 (7%)

Query: 22  DSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT-SLGAIEQWD 80
           D + A+  A      + SGV SHGV R   +  Q+E+G + P  +P+ +    G   + +
Sbjct: 36  DPDIAEEVAAHLVDASLSGVESHGVMRVLEYAAQVESGYLTPSGRPQVLRDDTGGPTRIE 95

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICW--- 137
           A   IG    +   D   + A   G+  +++R+  H  R G++   AAE G + IC    
Sbjct: 96  AGGGIGIPALRLAYDTCCDEARARGLSALSIRHVGHTGRHGAFAEAAAEAGCLTICLGGG 155

Query: 138 -TNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFSYGMLEVNRLAGRQL 193
              +   + P G     + TNP  + IP     P+ + D + S  + G +   R AG  L
Sbjct: 156 NRQTWRQVAPHGGARAMLPTNPWCIGIPGGDRGPVVL-DFATSKIAGGWIYAARSAGALL 214

Query: 194 PVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDN 253
           P     D  G+ T+ P        ILP G  KG G++++ +++   L  G S  E     
Sbjct: 215 PEGCVIDAAGHPTRNPEDYFAGGAILPAGGHKGFGLALLGELVGEALL-GPSTTEC---- 269

Query: 254 SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAE 313
                 + + IA+  ++  + P   A  + ++D +     A  +  + +PG       A 
Sbjct: 270 ------NWLLIALSAERFREAPAMAAAAEEVLDELRRCPPAPGSSGVEIPGERERAHRAA 323

Query: 314 NRRNGI-TVDDSVWAKIQAL 332
           +   GI +V    W +I+ L
Sbjct: 324 S--GGIVSVPRDTWTQIERL 341


>UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium leguminosarum
           RepID=C6B4N9_RHILS
          Length = 334

 Score = 72.4 bits (176), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 84/322 (26%), Positives = 138/322 (42%), Gaps = 35/322 (10%)

Query: 21  VDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWD 80
           VD+  + AC   F RT        G   F  ++  L +G I  DA+P+    L A+ Q D
Sbjct: 35  VDATLSAAC---FGRT------ELGFPHFVDYLTSLRDGRINGDAKPRFNHVLPALIQAD 85

Query: 81  AQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNS 140
           A   I  L    + D  ++     GI ++  RN+      G Y  + A+ G I I   N 
Sbjct: 86  ADGGIAQLGFDLIYDDFVKCVKTFGISVLTQRNSYTAGELGYYVRRLAQDGLISIAAANG 145

Query: 141 IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDG 197
            A+M      E    TNPL   +P     P  ++D + S  ++  + +   A  QLP+  
Sbjct: 146 PALMAAAEGGERVYCTNPLAFGVPMPEPLPPVVIDQATSATAF--ITLAEAAKAQLPIAH 203

Query: 198 GF--DDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSD 255
           G   D+ G +T +P V      +LP G +KG  ++++++M++  LS  A   +     S 
Sbjct: 204 GMAIDETGAITTDP-VKAMLGALLPFGGYKGGNIALIVEMLSAGLSGAAWSLDAGHFLSG 262

Query: 256 EYGISQIFIAIEVDKLI---DGPTR-DAKLQRIMDYVTSAERADENQAIRLPG-HEFTTL 310
           E+ ++     I +       D P R  A+L+R+            ++ +R+PG       
Sbjct: 263 EHPVNAGMTVIALFPAAADSDFPERAKAQLERL-----------RSRGVRIPGDRTMPAS 311

Query: 311 LAENRRNGITVDDSVWAKIQAL 332
           +AE  R  + VD  V   I+ L
Sbjct: 312 VAETDR--LDVDIGVLETIRRL 331


>UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=B6A4N6_RHILW
          Length = 344

 Score = 72.0 bits (175), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 60/245 (24%), Positives = 108/245 (44%), Gaps = 12/245 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T   L      +    G+++  A A A +          SHG+ R    ++ +++G + 
Sbjct: 6   LTIADLHGRVEAIFRKAGLNAVQAGALARVIVAGERDACKSHGIYRIEGALRTVKSGKVK 65

Query: 63  PDAQPKRITSLG-AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           PDA P+   + G AI + +A     N   +  +    E     GI  + + +  H+    
Sbjct: 66  PDAVPELDLNEGSAIVKVNADGGFANAAFELGVPALAERTRKLGIAALVINDCTHF---- 121

Query: 122 SYGWQAAE----KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSM 175
           S  W   E    +G  G+    S A + P G  +  +GTNP     P   T   + D + 
Sbjct: 122 SALWPEVEAVTKEGLAGLVMCPSYATVAPAGGNKPLLGTNPFAFGWPRKDTSPYVFDFAT 181

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDM 235
           S+ + G +E++R AG+QLP     D +G+ T +P        +LP G  KGS +  ++++
Sbjct: 182 SVAARGEIELHRRAGKQLPEGWAIDADGHPTTDPEAALAG-AMLPFGGHKGSAIGTMIEL 240

Query: 236 IATLL 240
           +A ++
Sbjct: 241 LAGIM 245


>UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella
           bronchiseptica RepID=Q7WEF1_BORBR
          Length = 356

 Score = 71.6 bits (174), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 73/304 (24%), Positives = 125/304 (41%), Gaps = 23/304 (7%)

Query: 14  RVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSL 73
           R+    G++   A A A    R    G  SHG+     ++  L +G +     P+ I   
Sbjct: 21  RLFERNGLEPAKAAAVARSLVRADMMGHDSHGLALASWYLDALADGQMASQGAPEVIADR 80

Query: 74  GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYI 133
           GA   W+ QR  G    ++ M+  +E    HG     + N+ H     +Y  Q   +G +
Sbjct: 81  GACFAWNGQRLPGAWLIERAMEAGVERVRTHGSATCTIANSFHAGALAAYLEQLTAQGLL 140

Query: 134 GI--CWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFSYGMLEVNRLAG 190
            I  C   +   + P+G  E     NPL   IP++   M+ D+S S+ +          G
Sbjct: 141 AILTCSGPASRAVAPFGGTEALFSPNPLAAGIPTSQAPMLMDISCSITTTNRTRQLARQG 200

Query: 191 RQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG----YWKGSGMSIVLDMIATLLSDGAS 245
           R  P       EG  T +P  V++    +LP+G      KG  M+++++ +   LS    
Sbjct: 201 RAFPAAWALTREGEPTDDPRQVVDHGGSLLPVGGVDHGHKGYAMALMVEALTQGLSG--- 257

Query: 246 VAEVTQDNSDEYGI-SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ----AI 300
                  N+   GI + I++ I   +   G    A   R  D++ ++  A+  +    A+
Sbjct: 258 ----YGRNAAPTGIVTNIYLHILDPEAFGG---RAAFLRETDWMAASCTANPPRPGVSAV 310

Query: 301 RLPG 304
           R+PG
Sbjct: 311 RVPG 314


>UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholderiales
           RepID=Q46QD8_RALEJ
          Length = 352

 Score = 70.5 bits (171), Expect = 7e-11,   Method: Compositional matrix adjust.
 Identities = 80/324 (24%), Positives = 128/324 (39%), Gaps = 12/324 (3%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           V  S GV  E A   A    R+   G  +HG+ R P ++ +L  GD  P A        G
Sbjct: 17  VFESCGVAPEHAVEAAAALVRSELRGYKTHGMTRVPSYVDRLRAGDFNPRATMSHRAFAG 76

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
            I   DA  ++G +     +   +E        LVA+++  H    G +   AAE G   
Sbjct: 77  GI-VLDADGAMGQVAGPHAVRLGLEALESSASVLVAVQSCGHLGALGIHALLAAEAGAFC 135

Query: 135 ICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGR 191
           +    +  V+   G     IG NP+    P     PI   D++ S+ + G + +    G+
Sbjct: 136 MVGQRTPPVLGMEGFSGPAIGHNPIAFGCPLPGQAPIVF-DVACSVAARGHILLAAREGK 194

Query: 192 QLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS---DGASVAE 248
            +P     D +G  T +         +LP G  KG G++++++ +A  L+   D  S   
Sbjct: 195 PIPEGWALDADGQPTTDAQRALAGS-LLPTGGHKGIGIAMMVECLAGALAATADSLSPER 253

Query: 249 VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFT 308
               +    G    F+ +   +   G          M   T    A      RLPGH   
Sbjct: 254 NHVGSGGAVGRQGGFVWLVKPEAFSG---QGVFADYMAQWTGNYLAAGGGDARLPGHRGD 310

Query: 309 TLLAENRRNGITVDDSVWAKIQAL 332
           TL  E R +GI + D++  ++ AL
Sbjct: 311 TLEREGRAHGIALPDAIARELGAL 334


>UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Tax=Bacteria
           RepID=Q168E2_ROSDO
          Length = 331

 Score = 68.2 bits (165), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 22/335 (6%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           + E ++A   + L++ G     A   A         G    G+     +  QLE G +  
Sbjct: 5   SLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDG 64

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            A P       A    +A          + +  A++ A   G   +A+ +A+     G +
Sbjct: 65  HAVPDVTNPRPAAIHVNANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYF 124

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITM-VDMSMSMFSY 180
             Q A+ G IGI +TN+  ++   G K   IGTNP+  ++P  +  + M  D S +  + 
Sbjct: 125 TEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIAFSVPDGAGGVAMQFDQSTTTVAL 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + +  G+Q+P+    D +G  T +P    +   ++ +G  KG G  ++ +++A  +
Sbjct: 185 GKITMAKALGQQIPLGWALDAQGKPTTDPQAALEG-SLVSVGGHKGWGFGLMAEILAAGM 243

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      SV  +       + + Q +I      LID  + +A  +R+      ++ A ++
Sbjct: 244 TGSVLSGSVKPLKAPQGPPHDLGQFYI------LIDPQSGEAFAERL---AALSQAATKD 294

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  R+PG     +        + V D VW ++Q L
Sbjct: 295 EGARMPGQSRQIM------QEVEVVDQVWNRLQEL 323


>UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2BBF
          Length = 329

 Score = 67.4 bits (163), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 73/272 (26%), Positives = 114/272 (41%), Gaps = 10/272 (3%)

Query: 52  FIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVAL 111
           ++  LE G I   A P+ +  L A    DA   I  L   ++ DR  + A D GI ++ +
Sbjct: 61  YLDGLEAGRINGAAVPRSVNRLPAAHLVDADGGIVQLAFDEVFDRFAQSATDLGISILNI 120

Query: 112 RNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITM 170
            NA      G Y  + A +G I +   NS A+M  +G+++   GTNPL  A+P      M
Sbjct: 121 MNAFPAGELGYYTMRLARRGLIALAGGNSPALMSLFGSRDTVTGTNPLSFALPHPQGPRM 180

Query: 171 VDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMS 230
            D + S  ++  +      G  +P       +G  T +P        +LP G  KGS ++
Sbjct: 181 FDQASSATAWVNIRDAADRGESIPEGWSQAPDGTATTDPEAGLAG-SLLPFGGVKGSNLA 239

Query: 231 IVLDMIATLLSDGASV-AEVTQDNSDEYGISQIFIAIEVDKLIDGPT-----RDAKLQRI 284
           ++++++A       SV A    + +   G     IAI  D      T       A+L R 
Sbjct: 240 LMIELLAAHGGANFSVDAPPIDEGTTTPGTGLFVIAISADAFDPEYTLRVEEHLARLDR- 298

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRR 316
            ++     R   +  I LPG   T LL    R
Sbjct: 299 -EFGIDFGRKRNDTVINLPGDLHTALLERAAR 329


>UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11D61_MESSB
          Length = 360

 Score = 67.4 bits (163), Expect = 7e-10,   Method: Compositional matrix adjust.
 Identities = 66/275 (24%), Positives = 115/275 (41%), Gaps = 24/275 (8%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T E  +    R L+  G   E A             G    G+NR    I +     
Sbjct: 21  VRLTVEGARDLTRRALVGAGYSVEEAKIIQSQLVTNALDGYGPAGLNRALAIIME----- 75

Query: 61  IIPDA-QPKR----ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNAN 115
             P A +P+R    +         D   ++G L   +  + A+E A   G  +V + N  
Sbjct: 76  --PRAREPRRAIRIVHETPNSALLDGGNNVGYLACWRASEVALEKARATGFAVVGVNNCP 133

Query: 116 HWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVD 172
              R   Y    A  G++ +  T+ +  + P G ++  +GTNP+  A P+    PI +VD
Sbjct: 134 FSGRNAHYVEPLARAGFVALHTTSGMPHVLPLGGRKAVMGTNPICFAFPTKGRDPI-IVD 192

Query: 173 MSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIV 232
           MS     +G + ++   G  LP   GFD +GN T +     K   + P G  KG  +S+V
Sbjct: 193 MSTLAIMWGDVLLHARTGEPLPEGVGFDSDGNPTTDASKAAKG-GVAPFGGHKGYALSLV 251

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIE 267
           + ++  +       A + +  S +Y  + +FI ++
Sbjct: 252 VQILGLMAG-----AHLPRGLSSDY--AGLFIVVD 279


>UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB34_SCHJA
          Length = 232

 Score = 66.2 bits (160), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 42/189 (22%), Positives = 97/189 (51%), Gaps = 13/189 (6%)

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPIT---MVDMSMSMFSYGML 183
           A ++G IG+ +TN+  ++ P  A++  +GTNPL +A P        ++DM+ S  + G +
Sbjct: 2   ALQEGLIGLAFTNTSPLVFPTRARKLAVGTNPLTLAAPGKVPDDHFVLDMATSAVALGKI 61

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLDMIA 237
           E+NR  G ++P+  G D +G    +P ++     ++P+G       +KG G+ ++++++ 
Sbjct: 62  EMNRRRGLEIPIGWGADQDGKTCVDPNLVVTKGGLMPLGGEEEHSGYKGYGLGMLVEILC 121

Query: 238 TLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            ++++      V +      +  + Q F+AI+       P  + +L   ++ + +    +
Sbjct: 122 GIIANADFGPNVRRWMTTEKQANLGQSFLAIDPKAF--APGFEQRLSEYVNIMRNLPPVN 179

Query: 296 ENQAIRLPG 304
           + + + +PG
Sbjct: 180 DKEPVVVPG 188


>UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaproteobacteria
           RepID=Q1QWQ4_CHRSD
          Length = 355

 Score = 66.2 bits (160), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 70/324 (21%), Positives = 130/324 (40%), Gaps = 31/324 (9%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           G  +E A+  A +       G ++HGV     ++  L+ G+   D +   +T    +   
Sbjct: 21  GATAEVAETTASILVEGDLLGHHTHGVKLAKGYLNDLKAGNACGDHRQLALTESSPVAAM 80

Query: 80  -DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWT 138
            D    +G     + +  A + A   GIG+V L+ ++H     +Y     E+G + I  +
Sbjct: 81  IDGHYVLGPYLVTRALAHARQAADGFGIGIVTLKRSHHIACLAAYLRPLVEQGLVPIVLS 140

Query: 139 N--SIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYGMLEVNRLAGRQLP 194
           +  ++A + P+G        +PL + IP    P+ ++D+SMS  + G +   R  G +L 
Sbjct: 141 SDPAVASVAPYGGTTPVYTPDPLAIGIPGREHPL-LIDVSMSSITNGTVNKTRAEGGKLA 199

Query: 195 VDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIVLDMIATLLSDGASVAE 248
                 + G ++ +P          ILP+G      KG  + ++++ + + L        
Sbjct: 200 HPAILTNRGTVSDDPEDFFTTPPGSILPLGGQAFGHKGFALGLMVEALTSALGGFGR--- 256

Query: 249 VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD-------YVTSAERADENQAIR 301
             +D   ++G S   + I+       P R    Q  +D           +ER D    +R
Sbjct: 257 --KDAPTQWGASATVMVID-------PARFGGTQAFLDETDFLARQCLDSERVDPEVPVR 307

Query: 302 LPGHEFTTLLAENRRNGITVDDSV 325
           LPG           R+GI +   V
Sbjct: 308 LPGQSGLAKRQRYLRDGIPLPGDV 331


>UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98CD3_RHILO
          Length = 333

 Score = 65.1 bits (157), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 75/336 (22%), Positives = 146/336 (43%), Gaps = 17/336 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ +Q +       +  G + E A +           G+ + G++ F  +++ LE G 
Sbjct: 1   MQLSLDQARGLCRMAALGAGANEEAAQSLTASIIAAEAEGLSTVGLSHFIDYLEALEAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P       A+   DA+  + +    + +D   + A   G+ + + +NA      
Sbjct: 61  IDGNADPVITRPALAVYLSDARGGLAHTGFDRTIDDLAKAAKLFGVAIFSQKNAYTCGAL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
           G +  + A +G +    TN  AV+   G+ +    TNP+  A P+    P+ ++D S S 
Sbjct: 121 GYFTGRLAAQGLVSFAATNGPAVLAGSGSVKPVYCTNPMSFAAPAADGAPL-VIDQSSSA 179

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++  +      G+++P     D  GN T +P    K   +L  G  +G+ ++++++++A
Sbjct: 180 TAFVNIRKAAEDGKKIPEGWALDASGNPTTDPAAAMKG-AMLAFGGQRGANIALMVEVLA 238

Query: 238 TLLSDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             +S GA+    A       D  G     +AIE  KL+D P  +   QR+ D +   +R 
Sbjct: 239 AGIS-GANWSLDAPWFTGGPDSPGTGLFVLAIE-PKLLD-PDFE---QRMKDQL---DRL 289

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
                + +PG        + +  GIT   +V  +I 
Sbjct: 290 RRRFGVHVPGRARAEAAEKAQARGITAPKAVVQRIS 325


>UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C5312
          Length = 350

 Score = 65.1 bits (157), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 90/329 (27%), Positives = 136/329 (41%), Gaps = 31/329 (9%)

Query: 20  GVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQW 79
           GV +  A   A         G  SHGV R P+++  +  G     A    ++   A+   
Sbjct: 21  GVPTTDAATVARSLVDANLCGHDSHGVMRVPQYLDFIRKGTYKAGAPLTVLSETPAVVAA 80

Query: 80  DAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTN 139
           DA   +G +   +++D+ +  A   GI    LRN  H  R G Y    A++ +      N
Sbjct: 81  DAGWGLGQVQTYRLLDKLVPKAKALGIAAGTLRNCGHTGRLGEYAEFVAKENFALFAAVN 140

Query: 140 SIA----VMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGMLEVNRLAGRQLP 194
           S      V PP G  E RI TNP+ +  P ST   ++D   S  + G  +V     ++ P
Sbjct: 141 SHGSGRRVAPP-GGTEGRISTNPICMGTPTSTDPVVIDFGTSSVAEG--KVRAQFQKKEP 197

Query: 195 VDGGF--DDEGNLTKEPGVIEKNRR--ILPMG---YWKGSGMSIVLDMIATLLSDGA--- 244
              G+  D  G  T +P V+    R  +LP G    +KG G+ ++LD++   LS GA   
Sbjct: 198 AGEGWLIDHTGQPTTDPSVLYNEPRGALLPFGGTQAYKGFGLGLLLDLLCGGLSGGACSN 257

Query: 245 -SVAEVTQDNSDEYGI--SQIFIAIE-VDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
            +     Q N+  + +    +F  +E   K  DG         +  YV S   A     I
Sbjct: 258 PTFPLAGQGNAAVFVLFNPALFGGVEHFLKETDG---------LTAYVRSCPTAAGAGTI 308

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            LPG    T   +  ++GI V D  W  I
Sbjct: 309 TLPGDPERTAKGKRTKDGIPVPDGTWELI 337


>UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3MEC9_RHISN
          Length = 381

 Score = 64.7 bits (156), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 7/219 (3%)

Query: 31  EMFARTTESGVYSHGVNRFPRFIQQLE---NGDIIPDAQPKRITSLGAIEQWDAQRSIGN 87
            + A T  + ++      FP  +  L+   +G I  + QPK      A    DA R I  
Sbjct: 74  SLVAATMSAALFGPPTLGFPHLVDYLDSFRDGRISTNPQPKLNRPFAAFFVSDADRGIAQ 133

Query: 88  LTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPW 147
           L   +  D+ +E     G+ +    N+      G +  + A +G +G+  TN+ A++   
Sbjct: 134 LGFDQAFDQFVETVRHFGVAIFTQTNSYTAGELGYFVRRLAAEGIVGLAATNANAMVVAK 193

Query: 148 GAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGN 204
                   TNPL    P    +P  ++D + S  ++  +      GR +P     D +GN
Sbjct: 194 PGGPAVYSTNPLAFGFPMGDGSPPMIIDQASSATAFVNIVAAASEGRSIPAGWAVDADGN 253

Query: 205 LTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
            T++P +  K   +L  G  KG+ ++++++M++  LS G
Sbjct: 254 DTEDPNLALKG-ALLAFGGRKGANVALMVEMMSAGLSGG 291


>UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emericella nidulans
           RepID=C8VKP5_EMENI
          Length = 230

 Score = 63.2 bits (152), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 55/236 (23%), Positives = 100/236 (42%), Gaps = 37/236 (15%)

Query: 94  MDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECR 153
           M  AI+ A  +GIG+V++ ++NH+    +Y  QA +   I + +T+S   MPP+G KE  
Sbjct: 1   MAEAIKRAEIYGIGMVSVNHSNHFGMAATYVLQALQANMISLVFTSSAKQMPPFGGKETP 60

Query: 154 IGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLP--VDGGFDDEGNLTKEPGV 211
           +G  P     PS                         R++P  +D       +  ++ G 
Sbjct: 61  LGIAPFAAGAPSN------------------------REVPYILDIAPSTPMSPQRKYGS 96

Query: 212 IEKNRRILPMGYWKGSGMSIVLDMIATLLS---DGASVAEVTQDNSDEYGISQIFIAIEV 268
             + + +       GSG++I++D+++++L+    G  V +  +D   +      FIAI+ 
Sbjct: 97  DRRTKGL-------GSGIAILMDIMSSVLTVAGFGGQVGDRYKDAKPQ-DAGHCFIAIKP 148

Query: 269 DKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDS 324
           D         A++  ++  V     A     +  PG     L  + RR GI   D+
Sbjct: 149 DVCFSVDDLKARMDTLVQRVHGVIPAPGFSEVLFPGEPEQRLCLQRRREGIPYADA 204


>UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2'
           RepID=UPI000169989B
          Length = 167

 Score = 58.9 bits (141), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 41/156 (26%), Positives = 80/156 (51%), Gaps = 4/156 (2%)

Query: 95  DRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRI 154
           D AI+LA+ +G+G+V + ++N     G Y  + A+ G + + W NS   + P+G  +  +
Sbjct: 7   DTAIDLASKNGVGVVTVSDSNFLGSLGYYVDKIAKNGMLAVLWNNSFPKVAPYGGVKAVL 66

Query: 155 GTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLA--GRQLPVDGGFDDEGNLTKEPGVI 212
           GTNPL  A P      V   +S  +     + + A  G+ +P       +G    +P  +
Sbjct: 67  GTNPLAFAAPRRNGRNVIADLSTGASAGSTITKAAELGQPIPEGIAIARDGTPITDPAKV 126

Query: 213 EKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAE 248
            K+  +LP G  KG  + ++++++A +++ GA ++ 
Sbjct: 127 -KDGALLPFGGAKGYALGLMVEIMAGVVT-GAGISH 160


>UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RZN2_9GAMM
          Length = 375

 Score = 57.8 bits (138), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 74/346 (21%), Positives = 131/346 (37%), Gaps = 26/346 (7%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L  + ++V  + G+  E A   A+        G  + G+  +      LE G + P A
Sbjct: 11  EFLHFSLSQVAQAAGMSEEHAGYIADAIVFAHRQGKLNQGLGVYEAIDLVLEIGVLDPLA 70

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
            P+ +    A   +D + S G  T   M   AIE A ++GI +    N N      SY  
Sbjct: 71  VPEMVDEGPAFAVFDGKGSSGYYTLTLMAKAAIEKAREYGIAIAFGGNHNDGGSFASYVH 130

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSM-------F 178
            A E+G +GI   N++ +  P+GA E  +   P    IPS     +  S+          
Sbjct: 131 MAYEQGMVGIASNNTVPLAAPFGAMENMLSCPPFDAIIPSGKEPPIWASLKFAEWYDADI 190

Query: 179 SYGMLEVNRLAGRQL--PVDGGFDDEGNLTKEP-------------GVIEKNRRILPMGY 223
           S  +L+   + G+ L  P  G   D      +P             G IE   R   +  
Sbjct: 191 SEAVLQDKPMKGKWLIDPESGELTDNAKPYAKPIPGYGRVWDATCAGQIE-TPRTYALNL 249

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           W   GM  +++ +    ++  ++ +    N+        F+ I+  +         +  +
Sbjct: 250 WN-EGMCSIINPLGKPSTELPTIEDFAAGNAAPSVGGSYFMCIDPSRFGPLAAVQERSDK 308

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            ++ V +A +      +R+PG      L +N    + V ++ WA  
Sbjct: 309 FINKVRNA-KPRPGHRVRIPGESGYRSLTQNEPT-VEVLENHWAPF 352


>UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=2 Tax=Burkholderia
           multivorans RepID=B9BUQ2_9BURK
          Length = 323

 Score = 57.4 bits (137), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 55/246 (22%), Positives = 109/246 (44%), Gaps = 15/246 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +V F+ ++ A        G     A + A+       +G  + G    P ++     G I
Sbjct: 10  RVAFDAIRRA--------GASEAVAHSLADAVISAELAGSKAVGFAHLPDYLDGFVIGRI 61

Query: 62  IPDAQPK-RITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             DA+P     +L AI + DA+  I  L   ++ D  +  +  +G+  +A+ N+      
Sbjct: 62  AADAEPDVSFPALAAI-RADARGGIAQLAYDRVFDELVGRSNTYGVVTLAVSNSFTVGEL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
           G Y  + AE+G + +   N+ A M    + +   GTNP+  A P   + P  ++D + S 
Sbjct: 121 GYYTRRLAERGLVALGTCNATAQMTTLESGKAVYGTNPVSFAAPVANARPF-VIDQASSA 179

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++  +     AG  +P     D+ G  T +      N  +LP G  +G+ ++++++++A
Sbjct: 180 TAFVSVRKAAEAGEAIPEGWAVDEHGRPTTDARA-AINGLLLPFGGARGANLAMMMEILA 238

Query: 238 TLLSDG 243
             ++ G
Sbjct: 239 AGVTGG 244


>UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=Paracoccus
           pantotrophus RepID=Q3S8E9_PARPN
          Length = 359

 Score = 56.6 bits (135), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 74/310 (23%), Positives = 124/310 (40%), Gaps = 24/310 (7%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRF----PRFIQQLE 57
           K+  ++ +    RV+ + G  +  A A A+        GV   G++R       F Q   
Sbjct: 32  KIAIDEARVLVERVMEATGYGAPEAAAIADHLLDCELRGVAMGGLSRAISVADHFAQHRG 91

Query: 58  NGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHW 117
             D +   + +R T   A    +    +G L   K  + AIE A   GIG+V    A   
Sbjct: 92  RIDTL---RIQRETPFSA--ALEGGNRVGYLLGAKATEIAIEKARASGIGMVTGHCAIFS 146

Query: 118 MRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMS 176
                Y  +    G++ +  ++   ++ P G  E   GTNP+    PS    ++ D+  S
Sbjct: 147 GMLSYYVERITAAGFVAVATSSVGPMVAPEGGTEALFGTNPIAFGFPSASEPVIWDIGTS 206

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMGYWKGSGMSIVLDM 235
                   +    G+ LP D  FD  G  T++P   +    R+   G  KGSG+++V+ +
Sbjct: 207 RIMLAETILAARLGQALPEDVAFDKSGQPTRDPHAALAGAFRV--WGGHKGSGLALVVQL 264

Query: 236 IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSAER 293
               L  G  V + T      YG   +F+   +D  + G   D   K+    D + +   
Sbjct: 265 FG--LMAGTPVVQET------YGSIGLFLQ-AIDPALFGDPEDFATKVAEFSDLLRANRP 315

Query: 294 ADENQAIRLP 303
            +   A+RLP
Sbjct: 316 VEGGPALRLP 325


>UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=1 Tax=Pseudomonas
           fluorescens Pf-5 RepID=Q4KAT3_PSEF5
          Length = 334

 Score = 53.1 bits (126), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 3/233 (1%)

Query: 13  NRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITS 72
            R  +  G   E A A AE        G+ S G      ++    +G I   A+P     
Sbjct: 20  QRCCLQAGSSQEVAQALAEATVSAQGHGLASVGFEHLADYLHGFASGRIAGLAKPLITQV 79

Query: 73  LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGY 132
             A+ + DA+  I  L   +      +     GI L AL N       G Y  + A +G 
Sbjct: 80  APAMIRCDARAGIAQLGFDQAFGAVCDSTRQLGISLFALHNGFTCGELGYYTRRLAAEGL 139

Query: 133 IGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLEVNRLAG 190
           + + + N  A++   G ++    TNPL  A P     + ++D + S  ++  L     AG
Sbjct: 140 VALAFCNGPALLTVAGQRQPIYSTNPLAFAAPCGDGRLLLIDQASSATAFVNLLKAAEAG 199

Query: 191 RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
             +P     D +G  T        +  +L  G  +G+ ++++++++A  ++ G
Sbjct: 200 EAIPEGWAVDAQGAATLS-AREAMHGALLAFGGSRGANIALLVEVLAGGVAGG 251


>UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma proteobacterium
           NOR51-B RepID=B8KS33_9GAMM
          Length = 354

 Score = 52.0 bits (123), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 52/238 (21%), Positives = 99/238 (41%), Gaps = 14/238 (5%)

Query: 15  VLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLG 74
           +L + G     A   A     +   G  +HG++  P ++Q  E G I   A P       
Sbjct: 16  ILEAIGTPPTPAAQVAHSLLESDRRGAPTHGLSLLPLYVQMAEAGVIDATATPVTHDLGA 75

Query: 75  AIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIG 134
           ++ + D + + G LT  + ++  I+ A   G+  + + +  H  R G +  +A +     
Sbjct: 76  SLARVDGRAAFGQLTGSEAVNVGIQKAQQQGVAAIGIGDGTHLGRLGEWAERACDADIAF 135

Query: 135 ICWTNS----IAVMPPWGAKECRIGTNPLIVAIPSTPIT----MVDMSMSMFSYGMLEVN 186
           + + N+    + V  P  A    +  NP+   IP+   T    +VD + S  S   +   
Sbjct: 136 LAFGNTGGGALTVAGPNKASRV-LAPNPIAFGIPTCGATENHVIVDFATSQVSGSRIREA 194

Query: 187 RLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG----YWKGSGMSIVLDMIATL 239
             AG +L  D     +G +T +P   ++    + P+G      KG G+ +  +M A++
Sbjct: 195 ANAGDRLNPDWVIAADGGITDDPQAFLDGLAALRPLGGASAGHKGFGLMVAAEMFASM 252


>UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium RepID=B6A0G2_RHILW
          Length = 333

 Score = 50.8 bits (120), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 58/239 (24%), Positives = 98/239 (41%), Gaps = 16/239 (6%)

Query: 14  RVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLEN---GDIIPDAQPKRI 70
           R  ++ G    TA +  +    T  + +Y   +  FP  +  L++   G I  +  P+  
Sbjct: 18  RACLAVGAGEATARSLVDA---TLSAAIYGPAMLGFPHMVDYLDSFREGRINCNPAPRCE 74

Query: 71  TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG--GSYGWQAA 128
               A    DA R I  L      D    LAA    GL      N +  G  G Y  + A
Sbjct: 75  RPYPAFFVADADRGIAQLGFDLAFDDL--LAAVRNFGLAVFTQTNSYTAGELGYYVRRLA 132

Query: 129 EKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP----STPITMVDMSMSMFSYGMLE 184
            +G +GI  TN+ A++           TNP+    P    S P+ ++D + S  +Y  + 
Sbjct: 133 GQGIVGIAATNANAMVVAKAGGPAVYSTNPMAFGFPLGEGSLPL-IIDQASSATAYVNIV 191

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
                 R +P     D+ G  T++         +LP G  KG+ ++++++M++  LS G
Sbjct: 192 AAAAERRAIPEGWAVDEAGKDTQD-AARALGGALLPFGGRKGANVALMVEMLSAGLSGG 249


>UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E470A0
          Length = 246

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 57/250 (22%), Positives = 112/250 (44%), Gaps = 32/250 (12%)

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIG--LVALRNANHWMR 119
           I D++P  +         D Q  +G +     + +AIE AA +GIG  L+ L   N ++ 
Sbjct: 3   IVDSEPVVLHETVGSAWLDGQGCLGAVVGSFAIKKAIEKAAQNGIGWVLIILGLWNGFL- 61

Query: 120 GGSYGWQAAEKGYIGICWTNS--IAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSM 175
                    +    G+C +N+   +V+P  G+K+  +GTNP+ +A         + D ++
Sbjct: 62  --------CKHVNRGLCMSNTWPASVVP--GSKQRVLGTNPICLAAAGLDGDYLLFDSAL 111

Query: 176 SMFSYGMLEVNRLAG-RQLPVDGGFDDEGNLTKEPGVIEKNRRILPM-------GYWKGS 227
           ++ +   ++    +G   +P   G D  G  T +   I  N  +LP+       G  KG 
Sbjct: 112 TVTAMRKVKEKTKSGDGSVPEGWGVDQNGQPTTDGASILNNGALLPLGGISPLTGGHKGF 171

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSDEYG-----ISQIFIAIEVDKLIDGPTRDAKLQ 282
           G+ ++++++ ++L+  A  +++ + + +          Q FIAI+      G     +LQ
Sbjct: 172 GLILLVEVLTSVLAGSAFSSDIGKKDGESGAFVGKDFGQTFIAIDPSHF--GGGFSDRLQ 229

Query: 283 RIMDYVTSAE 292
            ++DY    E
Sbjct: 230 FLLDYCRHLE 239


>UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rhizobium etli CFN 42
           RepID=Q2JYL8_RHIEC
          Length = 235

 Score = 43.9 bits (102), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 44/181 (24%), Positives = 71/181 (39%), Gaps = 10/181 (5%)

Query: 36  TTESGVYSHGVNRFPRFIQQLEN---GDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKK 92
           T  + +Y      FP F+  L++   G I  D  P       A    DA R I  L  + 
Sbjct: 37  TLSAALYGPPAVGFPHFVDYLDSFREGRINRDPAPTCERPYPAFFAADADRGIAQLGFEL 96

Query: 93  MMDRAIELAADHGIGLVALRNANHWMRG--GSYGWQAAEKGYIGICWTNSIAVMPPWGAK 150
                +E  A   +G+      N +  G  G Y  + A +G +GI  TN+ A++      
Sbjct: 97  AFKDLVE--AVRTLGVAVFTQTNSYTTGELGYYVRRLAGEGIVGIAATNANAMVVAKAGG 154

Query: 151 ECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTK 207
                TNP+    P    +P  ++D + S  +Y  +      GR +P     D+ G  T+
Sbjct: 155 PAVYSTNPMAFGFPLGDGSPPLLIDQASSATAYVNVAAAAAEGRSIPEGWAVDEAGQETQ 214

Query: 208 E 208
           +
Sbjct: 215 D 215


>UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC
           18224 RepID=B6QNX4_PENMQ
          Length = 136

 Score = 41.6 bits (96), Expect = 0.040,   Method: Compositional matrix adjust.
 Identities = 26/108 (24%), Positives = 53/108 (49%), Gaps = 8/108 (7%)

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDG 274
           +LP+G  KGSG+++++D+   LL+  +   +V     +  +  G+   F+  + +  +D 
Sbjct: 1   MLPIGGAKGSGLAMMMDIFGALLTASSFAGDVNDQYNNTRNPQGVGHWFMVFKPETFLD- 59

Query: 275 PTRDA---KLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGI 319
            +RD    ++  ++  V   E+ +    IR+PG   T +    R  GI
Sbjct: 60  -SRDELADRMDTLLGRVRPCEKVEGVDRIRVPGENATEMETRRRFEGI 106


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_P...   429   e-119
UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammap...   400   e-110
UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2...   397   e-109
UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococ...   396   e-109
UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia T...   395   e-108
UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobac...   395   e-108
UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax...   390   e-107
UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5               387   e-106
UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobu...   386   e-106
UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q...   382   e-105
UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular ...   380   e-104
UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Baci...   379   e-103
UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=...   378   e-103
UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxy...   376   e-103
UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophu...   376   e-103
UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaeroba...   375   e-103
UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacte...   374   e-102
UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria...   374   e-102
UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus ...   374   e-102
UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobact...   374   e-102
UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomi...   373   e-102
UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoana...   373   e-102
UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VE...   372   e-101
UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogen...   372   e-101
UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium ...   370   e-101
UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria...   368   e-100
UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistoso...   368   e-100
UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular ...   366   e-100
UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfito...   366   e-100
UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B...   365   1e-99
UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyru...   364   3e-99
UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenel...   362   8e-99
UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus...   362   9e-99
UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bact...   362   1e-98
UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria ...   359   6e-98
UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostri...   359   7e-98
UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus So...   359   8e-98
UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostri...   356   7e-97
UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacter...   355   1e-96
UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coeloma...   355   1e-96
UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunctio...   354   2e-96
UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2     354   3e-96
UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba...   353   6e-96
UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyc...   352   1e-95
UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria ...   348   1e-94
UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizo...   347   3e-94
UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteri...   346   6e-94
UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesen...   345   1e-93
UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacil...   344   2e-93
UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydro...   344   2e-93
UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococ...   344   3e-93
UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerot...   344   3e-93
UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   344   3e-93
UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62...   344   4e-93
UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN...   344   4e-93
UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyc...   342   1e-92
UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=...   342   1e-92
UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Pro...   342   1e-92
UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobac...   341   2e-92
UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacill...   341   2e-92
UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. ...   341   2e-92
UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp...   341   2e-92
UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=A...   341   2e-92
UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspi...   340   3e-92
UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella...   339   1e-91
UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=S...   339   1e-91
UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha pro...   337   3e-91
UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IP...   337   3e-91
UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostri...   337   4e-91
UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfo...   336   6e-91
UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfona...   335   9e-91
UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclo...   335   1e-90
UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostri...   334   2e-90
UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteo...   333   5e-90
UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evid...   331   2e-89
UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimon...   330   3e-89
UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium...   330   5e-89
UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   330   5e-89
UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   329   1e-88
UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   328   1e-88
UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH     328   2e-88
UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia...   328   2e-88
UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   328   2e-88
UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   328   2e-88
UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...   327   3e-88
UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   327   3e-88
UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C...   326   6e-88
UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   324   2e-87
UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomy...   324   2e-87
UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...   323   5e-87
UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 ...   321   2e-86
UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobac...   321   2e-86
UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitoba...   321   2e-86
UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organis...   321   3e-86
UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine b...   320   3e-86
UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID...   320   3e-86
UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_...   320   4e-86
UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...   320   5e-86
UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...   320   6e-86
UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family ...   319   8e-86
UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomon...   318   1e-85
UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadec...   317   3e-85
UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris ...   316   7e-85
UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaprot...   315   2e-84
UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholde...   314   3e-84
UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis...   314   3e-84
UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria ...   314   3e-84
UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Ac...   311   3e-83
UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS         310   5e-83
UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME       310   6e-83
UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriac...   309   9e-83
UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricauli...   308   1e-82
UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...   308   1e-82
UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=...   308   2e-82
UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteoba...   306   9e-82
UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NG...   304   2e-81
UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobact...   303   4e-81
UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochl...   303   5e-81
UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=...   303   6e-81
UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostri...   303   6e-81
UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=...   301   3e-80
UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Co...   300   5e-80
UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomy...   300   6e-80
UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobial...   298   2e-79
UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax...   298   2e-79
UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangiu...   297   5e-79
UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burk...   295   1e-78
UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobia...   295   2e-78
UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobi...   294   2e-78
UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaprot...   294   3e-78
UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha prote...   293   6e-78
UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...   292   1e-77
UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogen...   292   2e-77
UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinoba...   291   3e-77
UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromon...   290   7e-77
UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccu...   288   1e-76
UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   288   2e-76
UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...   288   2e-76
UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   287   3e-76
UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella...   287   5e-76
UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   287   5e-76
UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=...   287   6e-76
UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonoc...   286   8e-76
UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacte...   286   8e-76
UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   285   1e-75
UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteoba...   285   2e-75
UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphapro...   284   3e-75
UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria ...   283   5e-75
UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2...   282   1e-74
UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionace...   282   1e-74
UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...   282   1e-74
UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=...   282   2e-74
UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsi...   281   3e-74
UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax...   280   4e-74
UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus...   280   5e-74
UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacte...   279   8e-74
UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...   278   2e-73
UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata ob...   277   5e-73
UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...   276   5e-73
UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae...   275   1e-72
UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Ta...   273   5e-72
UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaprot...   273   6e-72
UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=...   273   7e-72
UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   270   6e-71
UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=...   270   8e-71
UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemoph...   269   1e-70
UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   266   1e-69
UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=...   265   1e-69
UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=...   263   5e-69
UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholde...   262   1e-68
UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=...   261   2e-68
UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=...   259   1e-67
UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaprot...   256   6e-67
UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98C...   252   1e-65
UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=...   251   2e-65
UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lip...   251   2e-65
UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobial...   251   2e-65
UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1...   250   6e-65
UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB...   249   1e-64
UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella ...   248   1e-64
UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate deh...   240   6e-62
UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=...   236   9e-61
UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium...   234   4e-60
UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomi...   233   9e-60
UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...   232   1e-59
UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria...   228   2e-58
UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=...   223   7e-57
UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacteri...   219   1e-55
UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein...   219   2e-55
UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3M...   218   3e-55
UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma p...   218   3e-55
UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...   216   1e-54
UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB...   209   9e-53
UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial ...   208   3e-52
UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emerice...   192   2e-47
UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persepho...   170   6e-41

Sequences not found previously or not previously below threshold:

UniRef50_B7G5R1 Dehydrogenase n=1 Tax=Phaeodactylum tricornutum ...   241   2e-62
UniRef50_UPI0000D54A60 putative malate/L-lactate dehydrogenase n...   179   9e-44
UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rh...   172   1e-41
UniRef50_A6D9E5 Putative uncharacterized protein n=1 Tax=Vibrio ...   135   2e-30
UniRef50_UPI00016955AA hypothetical protein Plarl_18817 n=1 Tax=...   132   2e-29
UniRef50_UPI0001AF36FA ureidoglycolate dehydrogenase n=1 Tax=Sal...   110   6e-23
UniRef50_C8Q676 Putative malate/lactate dehydrogenase n=1 Tax=Pa...   110   9e-23
UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicil...   104   4e-21
UniRef50_C1ZI52 Malate/lactate dehydrogenase n=1 Tax=Planctomyce...    88   4e-16
UniRef50_UPI0001B54124 malate/L-lactate dehydrogenase n=1 Tax=St...    80   1e-13
UniRef50_B5JCB8 Putative uncharacterized protein n=1 Tax=Octadec...    71   4e-11
UniRef50_A4FCS6 Putative uncharacterized protein n=1 Tax=Sacchar...    70   1e-10
UniRef50_A4FJI4 Putative uncharacterized protein n=1 Tax=Sacchar...    66   2e-09
UniRef50_C8Q675 1-aminocyclopropane-1-carboxylate deaminase-like...    63   2e-08
UniRef50_UPI00016A6773 hypothetical protein BuboB_33537 n=1 Tax=...    59   2e-07
UniRef50_UPI0000E47CD4 PREDICTED: similar to MGC80281 protein n=...    59   3e-07
UniRef50_Q28KZ8 Malate/L-lactate dehydrogenases-like protein n=1...    58   4e-07
UniRef50_Q88JF9 Putative uncharacterized protein n=2 Tax=Pseudom...    56   2e-06
UniRef50_A3JD36 Putative uncharacterized protein n=2 Tax=Gammapr...    55   4e-06
UniRef50_A7TC77 Predicted protein n=4 Tax=cellular organisms Rep...    53   2e-05
UniRef50_A7IHR1 Putative uncharacterized protein n=1 Tax=Xanthob...    50   9e-05
UniRef50_B5JCB7 Putative uncharacterized protein n=1 Tax=Octadec...    50   1e-04
UniRef50_B7RV64 Putative uncharacterized protein n=1 Tax=marine ...    49   3e-04
UniRef50_Q9KZG1 Putative uncharacterized protein SCO6991 n=1 Tax...    48   6e-04
UniRef50_Q89R00 Bsr2972 protein n=1 Tax=Bradyrhizobium japonicum...    47   0.001
UniRef50_B5JCB5 Putative uncharacterized protein n=1 Tax=Octadec...    45   0.005

>UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_PYRAB
          Length = 362

 Score =  429 bits (1104), Expect = e-119,   Method: Composition-based stats.
 Identities = 88/340 (25%), Positives = 157/340 (46%), Gaps = 8/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  ++L +   RVL   G   E A   A+        G+ SHGV R  R++  + +G 
Sbjct: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    + K I    +    D     G +   K M  AIE A   GIG+VA+RN+NH+   
Sbjct: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFS 179
           G Y   AAE+G IGI  TNS  ++ P G  E  +GTNP+ +A P+     ++DM+ S+  
Sbjct: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVP 191

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR-------ILPMGYWKGSGMSIV 232
            G LEV R  G ++P     + +G +T+    +               +G  KG G+S++
Sbjct: 192 IGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLM 251

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +D+++ +LS G     V   N     +   F+AI ++          ++  +++ + ++ 
Sbjct: 252 VDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSR 311

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + + I + G +    +    + GI +   V  ++  +
Sbjct: 312 KHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEI 351


>UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammaproteobacteria
           RepID=DLGD_SALNS
          Length = 332

 Score =  400 bits (1029), Expect = e-110,   Method: Composition-based stats.
 Identities = 297/332 (89%), Positives = 319/332 (96%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVTFE+LK AF RVL SR +  +TAD CAEMFARTTESGVYSHGVNRFPRFIQQL+NGD
Sbjct: 1   MKVTFEELKGAFYRVLRSRNIAEDTADKCAEMFARTTESGVYSHGVNRFPRFIQQLDNGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           IIPDA+P+R+TSLGAIEQWDAQR+IGNLTAKKMMDRAIELA+DHGIGLVALRNANHWMRG
Sbjct: 61  IIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY
Sbjct: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           GMLEVNRLAGR+LPVDGGFDD G LTKEPGVIEKNRRILPMGYWKGSG+SIVLDMIATLL
Sbjct: 181 GMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL 240

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           S+G+SVAEVTQ+NSDEYG+SQIFIAIEVDKLIDG TRDAKLQRIMD++T+AERAD+N AI
Sbjct: 241 SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAI 300

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           RLPGHEFT LL +NRR+GIT+DDSVWAKIQAL
Sbjct: 301 RLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL 332


>UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2BFJ4_9BACI
          Length = 364

 Score =  397 bits (1020), Expect = e-109,   Method: Composition-based stats.
 Identities = 86/336 (25%), Positives = 160/336 (47%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E+L+   + V I  GV  E A+  AE   +    G+ SHGV R   +I+++E   +
Sbjct: 6   KFDWEKLQKFCSDVFIKAGVKREDAETVAESLIQADLRGIDSHGVVRTDIYIKRIEKNMM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A+        A    +    +G +   K +D A+  A + G  +V ++ +NH+  G 
Sbjct: 66  NPFAEISIEEETDATALVNGHNQLGAIVGSKALDLALHKAKEKGAAIVGVKGSNHFGTGA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
            Y  +A EK  I +  +N+   MPP G     IGTNPL + +P+      ++DM+ S+ +
Sbjct: 126 FYVSKAIEKDMILLVLSNASQTMPPTGGVRPFIGTNPLAIGVPAGEEEAFILDMATSVVA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G  +P+    D  GN T       +   +LP+G  KG G+S+ +D++A +
Sbjct: 186 RGKIIVAAQKGEDIPLGWAIDKHGNPTTNAQDALEG-SVLPLGGPKGYGISMFIDILAGV 244

Query: 240 LSDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+       V  + ++ +D   +   F+AI+++  +   T   ++   +  + +  RA  
Sbjct: 245 LTGAGFGRYVNNMYENWNDPQNVGHFFLAIDINSFMPIETFKKRIDMYLREIKAEPRAIG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              I +PG   +  + E ++NGI +   V  +++ +
Sbjct: 305 VDKIYIPGEIESFKVKERKKNGIELPSKVVEELRLI 340


>UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococcales
           RepID=COMC_METJA
          Length = 344

 Score =  396 bits (1019), Expect = e-109,   Method: Composition-based stats.
 Identities = 93/336 (27%), Positives = 160/336 (47%), Gaps = 9/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +  E  K     VL   GV  E A   A++F      G  SHG+ RFP++I  L+ G+
Sbjct: 1   MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGN 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P    K +    A    D    +G +  KK M+ AI+ A + G+G+VA RNANH+   
Sbjct: 61  INPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G Y   A  +  IGI  TN+   M P+G KE  +GTNP+ +A         +DM+ +  +
Sbjct: 121 GYYSELAMNQDMIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIA 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +        ++P     D +G  T +P    +   ILP G  KG G+++ ++M++ +
Sbjct: 181 RGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALEG-CILPFGGPKGYGLALAIEMLSAI 239

Query: 240 LSDGASVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
              GA V    + T +  +      +FIAI  +  +       K+  ++D + ++E A+ 
Sbjct: 240 --GGAEVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEG 297

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + I +PG        +  ++G  +D +++ +++ +
Sbjct: 298 FE-ILIPGEIEERNKMKR-KDGFEIDKNLYNQLKEI 331


>UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGX7_KOSOT
          Length = 352

 Score =  395 bits (1016), Expect = e-108,   Method: Composition-based stats.
 Identities = 83/347 (23%), Positives = 158/347 (45%), Gaps = 18/347 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV  E+L      V+   G D E A   AE+       G+ SHGV R  R++  ++   
Sbjct: 1   MKVKREKLMNFTADVMKKMGCDDEKARVVAEVLVEADMRGISSHGVARLKRYVNHIKERI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ +P+ I         D    +G   AK  M++ IE A  +GIG+  +RN+NH+   
Sbjct: 61  IDPNGEPEIIFETPVTLAIDGNNGVGQHIAKFSMEKVIEKAKKYGIGMATVRNSNHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   A + G +GI  TN+  ++    ++E  +GTNP+  A P++     ++DM+ S+ 
Sbjct: 121 GYYAEMAVKMGLVGISLTNTAPLVVHTFSREALLGTNPIAFAFPTSEKYPILIDMATSVA 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGYWK 225
             G LEV     +++P     D+ G+ T +P  +  N                      K
Sbjct: 181 PRGKLEVYSRLNKKIPKGWAVDETGHTTTDPEKVLSNLKQRKGGGLLPLGGEGEEFSGHK 240

Query: 226 GSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIM 285
           G G+ ++++++ + LS G+   +  +       I+  F A++     +          ++
Sbjct: 241 GYGLVLLVELLTSGLSLGSFSYDTYKGKGK---ITHFFAALDPAIFGNPEKIKEHAMELI 297

Query: 286 DYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + + SA++AD  + I + G +      ++   G+ +D+  + +++ +
Sbjct: 298 NSLRSAKKADGKERIYVHGEKEYEKREKSLECGVEIDEPTYYELRKI 344


>UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CEH6_THET1
          Length = 383

 Score =  395 bits (1015), Expect = e-108,   Method: Composition-based stats.
 Identities = 87/349 (24%), Positives = 145/349 (41%), Gaps = 17/349 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V    LK+    V    GV  E AD  A++       G+ SHGV R  R+  +L  G 
Sbjct: 13  ISVDHMALKSWVTEVFCKLGVPREDADVTADVLVAADLRGIESHGVARLGRYTSRLMKGL 72

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A P  +    +    D    +G   A   M  AI+ A + G G VA+RN+NH+   
Sbjct: 73  ISPVANPVIVRETSSTALVDGNNGLGQPVAMWAMQLAIDKAREVGSGTVAVRNSNHYGIA 132

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   A E   IG+  TNS  ++ P G ++  IGTNP+ VAIP+      ++DM+ S+ 
Sbjct: 133 GYYAMMALEHDMIGMSLTNSSPLVVPTGGRKAVIGTNPIAVAIPAGKERPWVLDMATSVV 192

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILP------------MGYWKG 226
             G LEV     + +P+    D+ G  T +   +                       +KG
Sbjct: 193 PRGKLEVYARKNKPMPLGWAVDETGQPTTDAQRVLDALTARLGGGILPLGGTALFSGYKG 252

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRDAKLQR 283
             +S+++D++  +L       +V +          +   F A+ VD          ++  
Sbjct: 253 YNLSVMVDLLCGVLPGSNWGPKVDEPVDGKLVPSRVGHFFWALRVDAFRPIDEFKQEMDD 312

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  +  + +A+    I + G +   L  E  R G+ +   V   ++ +
Sbjct: 313 YIRMLKESPKAEGEDRIWVAGEKEWELQEEYSREGVPLYYKVVETLRGI 361


>UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax=Aciduliprofundum
           boonei T469 RepID=B5I9V7_9EURY
          Length = 371

 Score =  390 bits (1002), Expect = e-107,   Method: Composition-based stats.
 Identities = 80/343 (23%), Positives = 152/343 (44%), Gaps = 11/343 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+L      +     V  E A   A+        G+ SHGV R  R++  ++ G 
Sbjct: 19  VRIPREKLFNFVVEIFKRLDVPEEDAKIVADNLIMADMRGIESHGVQRLKRYVDGIKVGA 78

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +      K +         D   ++G +   K M  AIE A   G+G+V +RN+NH+   
Sbjct: 79  VNVHPNIKVVKESPVFAVLDGDEALGQVVGYKGMKMAIEKAKKVGVGIVGVRNSNHYGIA 138

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G Y + AA++  +G+  T S  ++   GA E  +GT+P+ VA P   +   ++DM+ S+ 
Sbjct: 139 GYYSYMAAKEDLVGVSMTTSRPLVAHTGAMEKFMGTSPISVAAPVEGSRPFLLDMATSVV 198

Query: 179 SYGMLEVNRLAGRQLPVDGGF-DDEGNLTKEPGVIE-KNRRILPM-------GYWKGSGM 229
             G +EV R   + +P D     + G +  +P  I      ILP+       G  KG G+
Sbjct: 199 PSGKIEVYRRKNKPVPGDWAISTETGEIIHDPNEILSPKGTILPLGGLGEISGGHKGYGL 258

Query: 230 SIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVT 289
             ++D++A +L+       V   +     +   F+AI+     D       +++ M+ + 
Sbjct: 259 GAIVDILAGILNGATWSKHVGGTSDKHSDVGHFFMAIDPGAFGDKEEFKKNMRKFMEELK 318

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +A++  + + I + G +         + G+ +   V  ++ A+
Sbjct: 319 NAKKHPKFERIWVHGEKGFLTYEAREKLGVPIYKKVLDEMNAI 361


>UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5
          Length = 369

 Score =  387 bits (995), Expect = e-106,   Method: Composition-based stats.
 Identities = 96/348 (27%), Positives = 165/348 (47%), Gaps = 20/348 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV +E LK   + V    G   E +    ++   +   G+ SHG+ R  ++  +++NG I
Sbjct: 5   KVKYEGLKKLCDIVFEKFGFSPEDSGTITDVLLLSDLFGIESHGIQRLVKYYSEIKNGLI 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D++PK I         DAQ  +G L  +K M+ AIE A   G+G+V +RN+NH+   G
Sbjct: 65  KVDSKPKIIKETPVSAILDAQAGMGQLAGRKAMNMAIEKAKTSGMGMVVVRNSNHYGIAG 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   A E+G +GI  TNS AV+ P   K+  +GTNP+ +++P+ P   ++D++ S+ + 
Sbjct: 125 YYAKMAEEEGLLGISMTNSPAVIIPTFGKDAMLGTNPIAISMPAKPYPFLMDIATSVVTR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILP----------------MGYW 224
           G +EV       LP+    D  G  T++P  I  N   LP                 G  
Sbjct: 185 GKIEVYNKRHEPLPLGLALDKNGEDTEDPYDILYN---LPKKLGGGLVPLGGSKELTGGH 241

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           KG G+++ +++   +LS G +   VT   S   G    F A++     D  + + KL   
Sbjct: 242 KGYGLALAVEIFTAILSGGITGNYVTLQGSSGSGTCHYFCAVDYSIFGDKNSIEDKLSEY 301

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ + ++++A     I   G +      +   NGI +++    +I  +
Sbjct: 302 LNELRNSKKAKGALRIYTHGEKEIESYKDKMENGIPMNEVTLKEIDEI 349


>UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobutylicum
           RepID=Q97LJ4_CLOAB
          Length = 369

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 90/344 (26%), Positives = 157/344 (45%), Gaps = 14/344 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E L      V    G   E +    E+       G+ SHGV R   + + + NG I
Sbjct: 12  KYKYEGLLNLCLEVFQRLGYTKEDSYTIGEVLLLADLFGIESHGVQRLTLYYKGIRNGSI 71

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                   +         D    +G + +KK M+RAI+ A   GIG+  ++N+NH+   G
Sbjct: 72  KVKNHMNIVKESPVSVVIDGDGGMGQIISKKAMERAIDKAKKTGIGMAIVKNSNHFGIAG 131

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   A  KG +GI  TN+ A++ P   +E  +GTNP+ +A+P+ P   ++DM+ S+ + 
Sbjct: 132 YYSRMAERKGLMGIAMTNTRAIVLPTYGREQMLGTNPISIAMPARPIPFLLDMATSVITR 191

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK-----NRRILP-------MGYWKGSG 228
           G +EV     ++L      DDEG  T  P  + K        +LP        G  KG G
Sbjct: 192 GKVEVYSKNNQKLNYGWAMDDEGRKTDNPDKVLKLANGNTGGLLPLGGDTEIFGGHKGYG 251

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +S  ++M  ++LS G +  E+ + N++  G+   F AI+     D    + ++   M  +
Sbjct: 252 ISFAVEMFTSILSGGLTSDEI-RGNNNTNGVCHAFAAIDYGLFDDKNAIEKRMSAYMQKI 310

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            ++++A     I   G +      +   NGI ++++   +I+ +
Sbjct: 311 RNSKKAYGASRIYTHGEKELEAYEDRMENGIPINENTIVEIKEI 354


>UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EMJ6_OCEIH
          Length = 356

 Score =  382 bits (983), Expect = e-105,   Method: Composition-based stats.
 Identities = 86/335 (25%), Positives = 156/335 (46%), Gaps = 8/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ + L+     +L    +  E A+  AE        GV SHGV R   +++++E+G 
Sbjct: 4   IAVSEKDLQRFCRDLLKQS-LPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGI 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I        +    A    DA    G +   K M+ AI+ A  +G   V + N+NH+   
Sbjct: 63  IERKTDISVVQDSFATALLDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTA 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
             Y   AAEKG+IGI  TN+  +M P+GAKE  +G NP+ ++IP        ++DMS S 
Sbjct: 123 SFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNPISISIPAGEGKKPIILDMSTSN 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G + V +     +P       +G  T +     +   +LPMG  KGSG++I++D+++
Sbjct: 183 VARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEG-FVLPMG-PKGSGLAIIIDILS 240

Query: 238 TLLSDGASVAEVTQDNSDEYG--ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            +L+       + +   D Y   +  +F AI ++   +       +   ++   S+E ++
Sbjct: 241 GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSE 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
               + +PG   +    E + NGI +   +  +++
Sbjct: 301 GFDQVYMPGDMESQRKKEYKENGIPLSQEIINELR 335


>UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular organisms
           RepID=C5CEA5_KOSOT
          Length = 373

 Score =  380 bits (977), Expect = e-104,   Method: Composition-based stats.
 Identities = 82/349 (23%), Positives = 155/349 (44%), Gaps = 19/349 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRF-PRFIQQLENGDI 61
           + F+ L+     V  + GV  E A   A +     + G+ SHGV R  P ++++++ G  
Sbjct: 11  LDFDVLENFMVDVFKALGVPEEDAKIVANVLITADKQGIDSHGVGRLKPIYVERIQAGIQ 70

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P    + +         D    +G++   K M  AIE A  +G+G+VA+RN+ H+   G
Sbjct: 71  NPITNFEIVRESPTTAVVDGHNGMGHVIGYKAMKLAIEKAKKYGMGMVAVRNSTHYGIAG 130

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
            Y   A ++G IGI  TN+   + P    E  +GTNPL   +PS      ++D + S+  
Sbjct: 131 YYVQMAVDEGMIGITGTNARPSIAPTFGVEPMLGTNPLTFGMPSDEEFPFILDCATSVSQ 190

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-----RRILPMG-------YWKGS 227
            G +EV   AG+++P      ++G    +   I ++       ++P+G        +KG 
Sbjct: 191 RGKIEVYARAGKEIPEGWVIGEDGKTRTDTEQILEDLKKGKAALVPLGGIGEETAGYKGY 250

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSD----EYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           G + V+++++  L  G  +  +T  +       Y I   FIAI ++   +          
Sbjct: 251 GYATVVEILSAALQGGNFLKMLTGFDEQGNRVPYRIGHFFIAINIEAFTELENFKKTTGE 310

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I+  + ++++A   + I   G +      E +  G  ++  +  ++  L
Sbjct: 311 ILRALRNSKKAPGAERIYTAGEKEYLTWLERKDKGAPLNHVLREQLVQL 359


>UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Bacillus
           RepID=YJMC_BACSU
          Length = 337

 Score =  379 bits (973), Expect = e-103,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 154/336 (45%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E+ K    + L   G++   A+  A++        V+SHGV     ++ +L  G 
Sbjct: 4   ITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLAGG 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQP    +       D     G++     MD AI++A   G+G+V   N++H    
Sbjct: 64  INPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
             +  +AA++  IG+  T++ +++ P+G +   +GTNP+   +P+      ++DM+ S  
Sbjct: 124 SYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPAKHKKPFILDMATSKV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R  G+++P   G D+ G    +P  +     +   G  KG G+SIV+D+ + 
Sbjct: 184 AFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV---SLSTFGGPKGYGLSIVVDVFSG 240

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LL+  A       +      +  +     AI      D  T   ++  ++D +  +  A 
Sbjct: 241 LLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFFTDWDTFLEQMDAMIDELQQSPPAV 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + + +PG         N++NGI++  SV+  +++
Sbjct: 301 GFERVYVPGEIEQLHEERNKKNGISIARSVYEFLKS 336


>UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=A2R6I4_ASPNC
          Length = 362

 Score =  378 bits (971), Expect = e-103,   Method: Composition-based stats.
 Identities = 85/321 (26%), Positives = 147/321 (45%), Gaps = 5/321 (1%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
             E+ K     +L+  G+ +E A + AE        GV +HG+ R P+++ ++ NG + P
Sbjct: 12  DPEKAKDFAAALLVKAGLMAEDARSMAECLVLADVRGVDTHGLARLPQYLDRVSNGRVNP 71

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
                       +   D     G + A + MD AI+ A  +GIG+V + ++NH+    +Y
Sbjct: 72  RPSINITQKTPVVAHLDGDNGFGFVVATRGMDEAIKRAEIYGIGMVTVNHSNHFGMAATY 131

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYG 181
             QA +   I + +TNS   MPP+G KE  +G +P     PS      ++DM+ S+ + G
Sbjct: 132 VLQALKANMISLVFTNSAKQMPPFGGKETLLGISPFAAGAPSNTEVPYILDMAPSVVAKG 191

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +      G  +P+    D +GN T +  V   N  + P+G  KGSG++I++D+++ +L+
Sbjct: 192 KIRRAARRGESIPLGWALDADGNPTTDANVAL-NGSMAPIGGPKGSGIAILMDIMSGVLA 250

Query: 242 DGASVAEVTQDNSD--EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
                 +V     D     +   FIAI+ D ++      A++  +   V     A     
Sbjct: 251 GAEFGGQVGDQYKDTKPQNVGHCFIAIKPDIIMSTDDFKARMDILAQRVHGVSPAPGFSE 310

Query: 300 IRLPGHEFTTLLAENRRNGIT 320
           +  PG     L  + R  GI 
Sbjct: 311 VLFPGEPEHRLGLQRRAEGIP 331


>UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1
           RepID=A1HMI4_9FIRM
          Length = 355

 Score =  376 bits (966), Expect = e-103,   Method: Composition-based stats.
 Identities = 83/336 (24%), Positives = 147/336 (43%), Gaps = 8/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  E L      +    GV  + +   AE       +GV SHGV+R P +++++    + 
Sbjct: 8   VKAECLLDYCASLFEKVGVPRDESYINAENLVDADLTGVESHGVSRMPIYLKRIRMNAVN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P    + ++   +    DA  S+G +   K M+ AIE A   GI  + ++N+NH+     
Sbjct: 68  PRCTLRTVSESPSTAVIDACNSMGAVVGVKTMELAIEKAKKTGISFIVVKNSNHYGTAAY 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           +   A +   IG   TN  A M PWG K+   GTNP  VA+P+      + DM+ S+ + 
Sbjct: 128 HAKIALKHNMIGFTATNGAARMAPWGGKDPFFGTNPFAVAVPAGKHLPIIADMATSVVAL 187

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRI---LPMGYWKGSGMSIVLDMIA 237
           G + +       +P+    +  G  T  P  +   + I   LP G  KGS +++++D++ 
Sbjct: 188 GKIILAAKKNLPIPLGWALNKFGEETTNPKEVFDGKVIGTPLPFGGPKGSAIALLIDVLT 247

Query: 238 TLLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
            +L+    G  + ++  D      IS +F AI V+  +      + +  ++  V     A
Sbjct: 248 GILAGSTFGPQIKDMYADFDQPTTISHLFGAINVEAFVPVSQFTSSIDELITMVKQVSPA 307

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
                I LPG        +    GI + ++V   ++
Sbjct: 308 KGVDEIFLPGEIELRKKEKRLAEGIPISEAVLEDLR 343


>UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LTF1_SYNAS
          Length = 373

 Score =  376 bits (966), Expect = e-103,   Method: Composition-based stats.
 Identities = 84/349 (24%), Positives = 161/349 (46%), Gaps = 19/349 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++L     ++  S GV  E A  CA+        G+ SHGV R  R++  + NG I+
Sbjct: 15  VNNQKLTQFVQKIFSSFGVTREDAVICADNLVLADLRGIPSHGVARLRRYVDGMSNGTIL 74

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P ++P  +    +    D Q  +G +        AIE A   G+G+VA+RN+NH+   G 
Sbjct: 75  PHSKPIIVREAPSTATVDGQAGLGQIVGHFSTQLAIEKARKTGVGIVAVRNSNHYGIAGY 134

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y     + G +GI  TN+  ++ P   ++  IGTNP+ +  P+       +DM+ S+   
Sbjct: 135 YTQMMLDAGLLGISMTNTAPLVVPTFGRKMIIGTNPISMTAPTRRNKPFFLDMATSVIPR 194

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGYWKGS 227
           G LEV    G+ +P     D +G    +   + +N                   G +KG 
Sbjct: 195 GKLEVYDRMGKDMPEGWAVDSKGQTATDATEVLRNMVARLGGGILPLGGEGELYGGYKGY 254

Query: 228 GMSIVLDMIATLLSDGASVAEV----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           G+++++D++  +LS GA    V             ++  F+A+ ++  ++      K+  
Sbjct: 255 GIALLVDILCGVLSGGAYADLVDIKGPGGAGQPALVAHFFMALNIENFVEMEIFMEKMDD 314

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++D +  + +A+    I + G +   L  ++R+ G+ ++++V   ++A+
Sbjct: 315 LIDRLKESAKAEGQNRIYIHGEKEYELYEQHRQTGVPLEENVHETLKAI 363


>UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C765_SPHTD
          Length = 355

 Score =  375 bits (965), Expect = e-103,   Method: Composition-based stats.
 Identities = 89/340 (26%), Positives = 158/340 (46%), Gaps = 8/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V    L+     VL+  G+  + A   AE+   +   G+ SHGV R   + ++L  G 
Sbjct: 6   VRVDAAVLQQFTADVLVGFGLSRDEAAITAEVLIASDIRGIDSHGVPRLGYYAERLRKGL 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I      + IT   A   +DA   +G+  A + M R IE A + G+ +  +R++NH+   
Sbjct: 66  INLTPNFRVITETPATIAFDADNGMGHPAAYRAMRRCIEKARETGLCMATVRHSNHFGIA 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y   A E+G  G+  TN+  ++ P  A+E  + T P+ VAIP+      +VD++ S  
Sbjct: 126 GYYAMMALEEGLCGVAMTNATPLVIPTFAREPYLSTAPIAVAIPAGRERPIVVDLATSTV 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE---KNRRILPMGYWKGSGMSIVLDM 235
           ++G +E+ R   + +P     D EGN+T +P              +G  KG  +++V+++
Sbjct: 186 AWGKIEIARREEKPIPWGWALDAEGNITTDPFAAVALTPLGATRELGSHKGYALALVVEV 245

Query: 236 IATLLSDGASVAEVTQD---NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   L+  A    V            I   F+A  +D         A++ +++  + +AE
Sbjct: 246 LCGQLAGAAWSRYVAGSRTVPPRPANIGHAFMAWRIDAFRPEEEFLAEIDQMLAELRAAE 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +    + +PG       A+ R NGI V   V A+++AL
Sbjct: 306 PVEGQPRVYVPGDPEDLAEADRRANGIPVHPKVLAELRAL 345


>UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacter heparinus DSM
           2366 RepID=C6Y337_PEDHD
          Length = 364

 Score =  374 bits (962), Expect = e-102,   Method: Composition-based stats.
 Identities = 78/348 (22%), Positives = 146/348 (41%), Gaps = 16/348 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +  +  QL+    R     GV  + A   A++ A + E G+ SHG+ R   +   L    
Sbjct: 8   IHFSATQLREFSTRTFTYFGVPYDEAVLAADVLAYSDEHGIDSHGIARLKTYFDLLRAKK 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  + + +    ++   D    +G +   K M+ AI+ A  HG G V++ N NH+   
Sbjct: 68  INPRPELRMLRERASVATIDGDNGLGLVVGPKCMEIAIQKARLHGSGWVSVCNTNHYGAA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y   A +   IG+  TN+   + P+   E  +GTNP+ +A P    P  ++D + S  
Sbjct: 128 GYYPVMALKDDIIGLSMTNTTKGVAPFNGAEKMLGTNPIAIAFPGLKEPPVVIDFASSAV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIV 232
           +YG +E+      ++P+    D +GN T  P  + +   +LP+G        KG  ++ +
Sbjct: 188 AYGKVEIAGRMAEEMPLGWCIDKQGNPTTSPTDMMQGGALLPLGADKNGSGHKGYCLAAM 247

Query: 233 LDMIATLLSDGASVA--------EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           +DM++ +LS                  +     GI   F A+++D   D     + +   
Sbjct: 248 VDMLSAVLSGANWGPFTVPFAIDSAPTERQVGKGIGHFFGAMDIDGFRDVNEFKSNIDDW 307

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + +         + +PG           + GI +   V + ++ +
Sbjct: 308 IHTMRNTAPIPGTGGVLIPGDPEREAYTLRMKEGIPLHPEVVSSLKTI 355


>UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria RepID=D1BPG4_VEIPT
          Length = 379

 Score =  374 bits (962), Expect = e-102,   Method: Composition-based stats.
 Identities = 85/344 (24%), Positives = 153/344 (44%), Gaps = 16/344 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
             +E LK          G   + AD   ++   +   G+ SHG+ R  R+ + + NG I 
Sbjct: 10  FPYETLKKLSMDAFQKFGFSEKEADIIQDVLLTSDLFGIQSHGMQRMVRYHKGITNGLIK 69

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+ +         D    +G L   K M+ AIE A   G+G+V++RN+NH+   G 
Sbjct: 70  IDAKPEIVKETPISAVIDGHDGMGQLLGHKAMEMAIEKAKKSGVGIVSVRNSNHYGIAGY 129

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSYG 181
           Y   A+++G IG   TNS A+M P  A++  +G+NP+   +P+ P+    D S ++ + G
Sbjct: 130 YAKMASDQGLIGFSCTNSEAIMVPVYARKAMLGSNPIAWTVPADPVDFFFDCSTTVVTRG 189

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE------KNRRILP-------MGYWKGSG 228
            LE+    G+  P     + +G  + +   +       +   ILP       +G  KG G
Sbjct: 190 KLEMYNKMGKATPDGWAVNKDGVPSTDAAEVLGNISRHEGGGILPLGGATEVLGGHKGYG 249

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
             ++ ++ +++LS G +  +       +  I   F+AI  +   D         + +  +
Sbjct: 250 NGMIAELFSSILSQGGTSNKCMV--GGKSNICHGFMAINPEFFGDPAEIKKHFSQFLQEL 307

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             A +A     I   G +    +A+ +  GI V +    ++Q L
Sbjct: 308 REAPKAQGQDRIYTHGEKEHESVAKVKAEGIPVLNGTMLEVQDL 351


>UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus cellulosilyticus
           DSM 2522 RepID=D2LY27_BACS4
          Length = 367

 Score =  374 bits (961), Expect = e-102,   Method: Composition-based stats.
 Identities = 71/335 (21%), Positives = 147/335 (43%), Gaps = 7/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +++L+    ++    G+    A   AE   +    G  SHGV R   ++++++ G I
Sbjct: 4   RFHWKRLETFCEKLFTKAGLPENDAKIVAESLVQADLQGTDSHGVVRADIYLRRIQAGMI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D + +       +   D +  IG++   + ++ AIE    HG   V ++ +NH+    
Sbjct: 64  NRDEEMEVHYDGP-VILLDGKNHIGSVVGNRALELAIEATKQHGTASVGVKGSNHFGTCS 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFS 179
            +  +A ++  I I  +N+   MPP G     +GTNPL +  P+      ++DM+ S+ +
Sbjct: 123 YFLQKAIKENIIMIIVSNASQTMPPTGGIRPFLGTNPLSIGAPAGRYAPFILDMATSVVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G+ +P +   D  GN T       +   +LPM   KG  +S+ +D+++ +
Sbjct: 183 RGKIISAAQKGKSIPKEWAIDKFGNPTTVAEDALEG-SVLPMAGPKGYAISMFIDILSGV 241

Query: 240 LSDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+       V  + ++  D   +   +I IE+ K +       ++ +  D +    +A  
Sbjct: 242 LTGAGFGRYVNNMYENWEDPQNVGHFYIGIEISKFMPIEEFKNRIDQYFDEIKREPKAPN 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + I +PG        +   +GI +   V  +++ 
Sbjct: 302 VEEILIPGEIEHRCRIKKMTHGIELPPKVEDELKR 336


>UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobacteriales
           RepID=COMC_METTH
          Length = 341

 Score =  374 bits (960), Expect = e-102,   Method: Composition-based stats.
 Identities = 87/335 (25%), Positives = 155/335 (46%), Gaps = 10/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E+       +L +  V  E++D  A++       G  SHG+ RFP+++  L +G 
Sbjct: 1   MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D          +    +     G++ A + M+ AIE A + G+GLV + ++NH+   
Sbjct: 61  IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G Y   A     IG+   N+   + P G ++  +GTNP+ + IPS    + VDM+ S  +
Sbjct: 121 GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G L      G  +P +   D EG  T +P +  K   ILP G  KG  +S +++++A  
Sbjct: 181 RGKLLEAARKGESIPENVALDAEGKPTTDPEMALKG-SILPFGGHKGYALSFMIEILAGP 239

Query: 240 LSDGASVAEVTQDNSDEYGI--SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L   A    VT   + E       + +AI+  K++D     A++   ++ V S+      
Sbjct: 240 LVGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSS------ 293

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +PG   +  +   R  GI +D+ +  +I  +
Sbjct: 294 GDVLIPGDIESMNIKRRRAEGIELDEKLLERILGI 328


>UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomicrobium roseum DSM
           5159 RepID=B9L199_THERP
          Length = 353

 Score =  373 bits (959), Expect = e-102,   Method: Composition-based stats.
 Identities = 85/344 (24%), Positives = 152/344 (44%), Gaps = 15/344 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+L+     V +  G+  E A   AE+       G  SHGV R   +++++E G 
Sbjct: 3   VRLPVEELQRFVTEVFLRTGLSEEDAAISAEILVAADVRGFDSHGVARLDYYVRRIEAGA 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +   +    A   +DA   +G  +A + M R IE A + G+ L  +R +NH+   
Sbjct: 63  VNLRPRFHAVAETPATIAFDADNGMGFPSAYRAMRRCIEKAQESGLCLATVRRSNHYGIA 122

Query: 121 GSYGWQAAE-KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
           G Y   A E  G IG+  TN+  ++ P  A++  + T P+  AIP+      + D + S 
Sbjct: 123 GYYATMALEVPGMIGVSMTNATPLVVPPHARDAYLSTAPIAFAIPAGKERPLVFDGATST 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY------WKGSGMSI 231
            ++G +E+ R   + +P+    D EG  T +P      R + P+G        KG  +++
Sbjct: 183 VAWGKIEIARRNRQPIPLGWALDAEGRPTTDPFAA---RFLTPLGAFPELRSHKGYALAL 239

Query: 232 VLDMIATLLSDGASVAEVTQDNS---DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +++++   L+ G     V    S           F+AI +D         A +  ++  +
Sbjct: 240 LVEVLCGQLAGGVWAKYVGGSRSETIGPSNTGHAFMAIRIDAFRPLEEFLADMDDMLGEL 299

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             A   D  + + +PG       AE R NGI V   V A ++ +
Sbjct: 300 RRARPTDGAERVLVPGDLEAETEAERRANGIPVHPEVLATLREI 343


>UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoanaerobacter
           ethanolicus CCSD1 RepID=C7IP78_THEET
          Length = 349

 Score =  373 bits (958), Expect = e-102,   Method: Composition-based stats.
 Identities = 87/337 (25%), Positives = 152/337 (45%), Gaps = 9/337 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++LK     +    G     A   AE    +   G+ SHG++  P ++++ + G   
Sbjct: 5   VDAKKLKELEVEIFKKAGFKESDAKIIAENLIYSDLRGIESHGISNLPIYVKRAKLGLYN 64

Query: 63  PDAQPKRI---TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
                  +     +  +   D + ++G + A K ++  +  A   GI    + N NH   
Sbjct: 65  LSGDIDILNLDKDIP-LLLIDGKNNMGQVAAYKAVEPLVNKAKKSGIAAAFIGNTNHCGS 123

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMF 178
            G YG   A    I I  TN+ A M PWG K   +GTNPL + IP     + +DM+ S  
Sbjct: 124 LGYYGNMIANNDCIFIGMTNAPASMAPWGGKVKFVGTNPLCITIPYNGQVINLDMATSTV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V    G ++P +  FD  G  T +P    K   + P+G +KG G+++++D+I+ 
Sbjct: 184 AKGKIYVALSKGDKIPDNWAFDANGKPTTDPQEALKG-TLYPLGGYKGFGLAMLIDIISG 242

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LL+    G  V  +         +  +FIAI +  L+     + K+   ++ + S  R+D
Sbjct: 243 LLTGSSWGPEVGSLHNTLDRGQDVGIVFIAINITDLMPIKEYNEKINCYIEKMKSVPRSD 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +N  I  PG      + E  +NGI ++D  + ++  L
Sbjct: 303 DNSEIMFPGEPELRKMEERLKNGIPINDKTYEEVIEL 339


>UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VEY1_9BACT
          Length = 372

 Score =  372 bits (956), Expect = e-101,   Method: Composition-based stats.
 Identities = 75/351 (21%), Positives = 148/351 (42%), Gaps = 19/351 (5%)

Query: 1   MK-VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG 59
           MK +  + L++    V I  GV  E A  C+++   +   G+ SHG+ R   +  +++ G
Sbjct: 10  MKYLPVDVLQSFMQEVFIKLGVPEEEAQICSDVLIASDLKGIESHGIGRLKMYYDRIKAG 69

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              P      +    A   WD    +G + +KK M  AI+ A  +G+G VA+RN+ H+  
Sbjct: 70  IQNPVTNIDVLRDKCATAVWDGNNGMGQVISKKAMQAAIDKAEKYGLGAVAVRNSTHFGI 129

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMV-DMSMSM 177
            G Y   A  +  IG+ ++N+   + P       +GTNP+    P+  P   + D + S+
Sbjct: 130 CGYYAEMAIRQNMIGLVFSNARPSICPTNGVSPILGTNPICFGAPTDLPYPFLYDAATSI 189

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-----KNRRILPMGY-------WK 225
              G +E      ++ P+    D EG    +   +      +   +LP+G         K
Sbjct: 190 SQRGKVEQLAREEKETPLGWAIDLEGKPYTDTKGLLIDLLKQKAAMLPLGGTEEITGSHK 249

Query: 226 GSGMSIVLDMIATLLSDGASVAEVTQDN----SDEYGISQIFIAIEVDKLIDGPTRDAKL 281
           G G++  ++++   L  G  +  +  ++       Y +   F+AI ++   D        
Sbjct: 250 GYGLATAVEILCASLQKGNYLNGLLGEDENGKPAPYRLGHFFMAINIEFFTDLVDFKKIT 309

Query: 282 QRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I   + +++       I + G +   +  + R+ GI +  ++   I+ +
Sbjct: 310 TSICKDLQNSQLFPGKNRIYVAGEKEYEIEQKVRKQGIPIIPNLEKNIRII 360


>UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogenase n=1 Tax=Clostridium
           sp. M62/1 RepID=UPI0001C34ECB
          Length = 379

 Score =  372 bits (955), Expect = e-101,   Method: Composition-based stats.
 Identities = 92/337 (27%), Positives = 163/337 (48%), Gaps = 6/337 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V    L++    +    G++   A   AE   +T   G+ SHG  R P + +++ NG 
Sbjct: 29  VRVEAGYLESFVRELFEKAGMERGDAQFHAEALVQTDLWGISSHGCMRVPAYFERMRNGA 88

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I      ++++  GA E  DA    G +  K+ M+RA+ELA  + I  V +RN+NH+  G
Sbjct: 89  INVRPNVRKVSGEGAFEVLDADAGAGFIAGKRAMERAMELAKKYHIAAVGVRNSNHFGAG 148

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             Y   AA++G  GI  TN + ++   GA     G NP+ VAIP+       +DM++S  
Sbjct: 149 AVYARMAAKEGMAGIAMTNVLPLVTAPGASRPVTGNNPIAVAIPTYGDFPFCLDMALSKV 208

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L +    G ++P+D   D+EG  T +P    K   +LP+G +KG G++ V+D+++ 
Sbjct: 209 AGGKLTLAIKRGEKIPMDWATDEEGRPTDDPEKAFKG-FLLPVGGYKGLGLAYVVDILSG 267

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +++ G    +   +    ++       F+A+++D +ID      ++      +      +
Sbjct: 268 VVTGGVFSHQMKSMYAQPTEPSLTGHFFVAVDIDAVIDREQMKQRMGEYFRRIKETPMWE 327

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           E   + LPG        E R NGI V    + ++  L
Sbjct: 328 EGAEMLLPGELEYRKEKERRENGIPVPVKTYEELLEL 364


>UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FVL5_DESHD
          Length = 351

 Score =  370 bits (952), Expect = e-101,   Method: Composition-based stats.
 Identities = 84/334 (25%), Positives = 160/334 (47%), Gaps = 6/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            + + +     R+L + GV +  A   + +   T+  G+ +HG++R P +++ L  G I 
Sbjct: 5   FSDQAMNDFCQRLLEASGVPATDAGIVSSILVDTSLEGIDTHGISRLPVYLKCLLKGRIN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P  + +      A+ + D    +G L A + M+ AI+LA  +GIG   ++N+NH+    +
Sbjct: 65  PKPKIQETIDA-AVARVDGDNGLGQLVAYRAMNSAIDLAKIYGIGFATVKNSNHFGAAST 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYG 181
           Y   AA +  IG  +TNS + +PPWG +    GTNP+    P      +VDMS S  + G
Sbjct: 124 YCKLAAAQQMIGQAYTNSPSGIPPWGGRAPYFGTNPISYGFPHAEYPVVVDMSSSTVARG 183

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            + +    G ++P     D +G  T       +   +LP+G  KG  +++  +++A ++S
Sbjct: 184 NIILAAKNGEEIPEGWAMDKDGKATTNAKAALEG-AVLPIGGAKGYTLALAAEVMAGIIS 242

Query: 242 DGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
             A  + V     +  +   I   F+AI + KL+       ++  ++  V +  +A+   
Sbjct: 243 GSAYGSHVGWIYDEGREPVNIGHSFLAINIAKLMPVEEFSQRMGDMIREVKAIPKAEGIT 302

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            IR+PG        + +++GI V + +  ++  L
Sbjct: 303 EIRIPGERRQANAEQRKQDGIPVAEGLLQELNML 336


>UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria RepID=A9KQQ8_CLOPH
          Length = 334

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 157/331 (47%), Positives = 209/331 (63%), Gaps = 2/331 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ ++ +   F RVLI  G   E A   A++FA  +  GVYSHGVNRFPR I  +E G 
Sbjct: 1   MRIQYDDMVKEFTRVLIKYGFSEEKAKLSAKLFADNSLDGVYSHGVNRFPRVISYIEKGY 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+    +  + G +E+WD    +GNL A+  MDRAIEL+  HGIG +A++N NHWMRG
Sbjct: 61  IKPEQTAAKTEAFGCVERWDGNLGMGNLNAQICMDRAIELSRTHGIGCIAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G+YGWQAA  G IGICWTN++  MP WGAK+ RIG NP IVAIP  S    + D +MS F
Sbjct: 121 GAYGWQAANAGCIGICWTNTMPNMPAWGAKDRRIGNNPFIVAIPRSSGAHVVADCAMSQF 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           SYG +E  RL G++LP+ GG+D+   +T +P  IEK  RILPMGYWKGSG+SI  D+IAT
Sbjct: 181 SYGKVEEYRLNGKKLPIPGGYDENDEITNDPAAIEKTSRILPMGYWKGSGLSIAFDLIAT 240

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           +LS G SV E+ +   DE+ ISQ+ IAI+     D    D  +  ++D + ++    EN 
Sbjct: 241 VLSGGNSVTEIGKLGEDEFAISQVMIAIDPSHFNDVALTDELINNVLDDIKASVPVKENG 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +I  PG        EN  +GI V + +W KI
Sbjct: 301 SIYYPGESSLNTRIENTEHGIPVQEEIWEKI 331


>UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistosoma
           RepID=C4Q0V1_SCHMA
          Length = 384

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 77/342 (22%), Positives = 159/342 (46%), Gaps = 14/342 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E++K    + L   G   + A A +++       G YSHG+NR   ++Q ++ G   
Sbjct: 30  ISTEEVKKFCIQCLQKVGAQLKHATALSDVLVAGDYRGHYSHGLNRLEMYVQDIQKGVCS 89

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +    +    D +  +G +     M+ AI+ A + GI  VA   +NH+   G 
Sbjct: 90  TDLEPTIVKETVSTALVDGKNVLGPVVGNFSMETAIKKANETGIAFVAAFGSNHFGIAGW 149

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFS 179
           Y   A ++G IG+ +TN+  ++ P  A+   +GTNP+ +A P        ++DM+ S  +
Sbjct: 150 YSLMALQQGLIGLAFTNTSPLVFPTRARRLAVGTNPITLAAPGKVPEDHFVLDMATSAVA 209

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVL 233
            G +E++R  G ++P   G D +G  + +P ++     ++P+G       +KG G+ +++
Sbjct: 210 LGKIEMSRRRGIEIPKGWGADTDGKTSVDPNLVMTKGGLMPLGGEEENSGYKGYGLGMLV 269

Query: 234 DMIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++  +++D A    + +         + Q F+AI+      G   + +L   ++ + + 
Sbjct: 270 EILCGIIADAAFGPNIRRWLSTDKPANLGQSFLAIDPKAFAPG--FEQRLSEYVNIMRNL 327

Query: 292 ERADENQAIRLPGHEFTTLLAE-NRRNGITVDDSVWAKIQAL 332
              D  + + +PG      + E +   GI     +   +  L
Sbjct: 328 PPVDNQKPVIVPGDFEREHMTECDELGGIPYPPVLIESLNRL 369


>UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular organisms
           RepID=B0EJK3_ENTDI
          Length = 370

 Score =  366 bits (941), Expect = e-100,   Method: Composition-based stats.
 Identities = 77/349 (22%), Positives = 155/349 (44%), Gaps = 18/349 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFP-RFIQQLENGD 60
           ++ F++L+     VL+++GV+   A  CA++  +  + G+ +HG+ R    +  +++ G 
Sbjct: 8   RIHFDELEKFIKDVLMAKGVEEPDAARCAKVLIQADKQGMDTHGIQRLKTIYCDRIDCGQ 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +        +         D    +G+  A + M  AI+ A  HG+G+V +RN  H+   
Sbjct: 68  LNTKTVFDIVKETETTAVVDGHNGMGHSIAMQAMQLAIDKAKKHGMGMVVVRNGTHYGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   AA++G IG    N+   + P  + E ++GTNPL+ A PS       +D + S+ 
Sbjct: 128 GYYPQMAAQQGCIGFSGCNARPSVCPCWSVEPKLGTNPLVFAFPSDEGFPFCLDCATSIV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK-----NRRILP-------MGYWKG 226
             G +E+    G++       D  G +  EPG + +          P       MG  KG
Sbjct: 188 QRGKIEMYAREGKKCQPGWVCDRSGKVLSEPGPMLEAFQKGTAACYPLGGYGEEMGGHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            G +  ++++++ LS    +++   +         + Q F+AI ++        + ++  
Sbjct: 248 YGYACDVEILSSALSGANFLSQCGGLRDGKKVPIELGQFFMAINIESFRPLADFEKQVGD 307

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I   + +A +A     I  PG +      E  + G+ + +   ++++ L
Sbjct: 308 IARELRAAAKAPGATRIYTPGEKEHETFLERSKKGVFIPEVTRSEMEKL 356


>UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FR90_DESHD
          Length = 349

 Score =  366 bits (940), Expect = e-100,   Method: Composition-based stats.
 Identities = 76/336 (22%), Positives = 144/336 (42%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L+    +   + GV         +        G+ SHGV+RFP ++++++ G +
Sbjct: 6   RYEVNTLRRFMEQAFTACGVSEADGQIVVDNLLYAELRGIKSHGVSRFPVYLRRIQMGAV 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P  Q         + + D    +G++     ++R +ELA   GI  V ++ +NH    G
Sbjct: 66  NPQPQISMEQRTPVLLKVDGDNGLGSVVMVHALNRGMELAEQLGICAVGIKGSNHCGASG 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
            Y   AAE+G + I  T+     PPWG ++   GTNP+   +P    P  +VD++ S+ +
Sbjct: 126 YYCELAAEQGLVSIVLTDGPPATPPWGGRKAYFGTNPMAFGLPRAQKPHIIVDLATSLAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G ++P     D EG  T +P        +LPM   KG  +S+V++ +A +
Sbjct: 186 RGKVIRAAAQGEKIPEGWALDREGLPTTDPQAALAG-VLLPMAGAKGYALSLVVEHLAGV 244

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       +V     + +    +    I ++ D  ++      + ++ ++ +     A  
Sbjct: 245 LVGAGFGKDVAWQYSEGNKPANVGHFIILVKADAFMEMADYHKRTEQFVEEIKKIPLAPG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + I+LPG             GI +D  + A +Q +
Sbjct: 305 TKEIKLPGERSWEQQQNTEAQGIILDADLQAALQTI 340


>UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B6HAQ0_PENCW
          Length = 357

 Score =  365 bits (939), Expect = 1e-99,   Method: Composition-based stats.
 Identities = 82/333 (24%), Positives = 147/333 (44%), Gaps = 5/333 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +    L+    ++LI+     E A+  ++        GV +HG NR P +++++    +
Sbjct: 13  NINHTDLQNFVKQILIANKTSPEHAEIVSKCLVSADLRGVDTHGSNRIPSYMERIRQNAL 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A P       A+ Q DA    G + A + M  AI +A   GIG+V+++++NH+    
Sbjct: 73  DPSAVPTIRQVTPAVAQVDAHNGFGFVAAHEGMKLAISMAQIFGIGMVSVKHSNHFGMSA 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
               QA E   + + +TNS   +P WG KE  +G +P+    P+      ++DM+ S+ +
Sbjct: 133 WLVQQALEADMMSLVFTNSSPALPVWGGKEKLMGVSPIACGAPAGEGRPFILDMAPSIAA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G ++P D   D +G  T +P    +   +LPMG  KGS +S+++D+ + +
Sbjct: 193 RGKIYKALRRGEKIPTDWALDKDGAGTDDPAEALQG-VMLPMGGPKGSALSVMMDVFSGV 251

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS  A    VT   D S    +    +AI+ D  +       ++  +   V  +E+    
Sbjct: 252 LSGSAFAGHVTNPYDPSKPADVGHFLVAIKPDLFMTIEEFKGRMDYLYQRVVDSEKMAGV 311

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             I  PG        +    GI    +    + 
Sbjct: 312 DRIYFPGEIEMITEEKRLAEGIPFATAEIESLN 344


>UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TYB0_METKA
          Length = 341

 Score =  364 bits (935), Expect = 3e-99,   Method: Composition-based stats.
 Identities = 92/336 (27%), Positives = 164/336 (48%), Gaps = 10/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  E L    +  L + GV  + A   AE+       G +SHGV R P +I+ ++ G 
Sbjct: 1   MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGA 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ + + I+   ++  +DA  S+G++   +    A+ELA  HG+G+VA+RNA+H+   
Sbjct: 61  IRPEMRIEEISRKSSVVLYDADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
           G Y    AE+G+IG     +   + P+G  +  +GTNP+ +A P    P  +VDM+ S+ 
Sbjct: 121 GYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVSIAFPRRDGPPIVVDMATSVV 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +       R++P D     +G  T +P    +   +LP G  KG  + + L+++A 
Sbjct: 181 ARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEG-ALLPFGGHKGYALCLALEVLAG 239

Query: 239 LLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            +   A+  +V  T D +       +F+A+++  L+D      +L+R++  V SA     
Sbjct: 240 PVVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSA----- 294

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + LPG           R GI + +     ++ +
Sbjct: 295 GDDVLLPGEPEFRRRERALREGIELPEGSVRAVREV 330


>UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenella corrodens ATCC
           23834 RepID=C0DY92_EIKCO
          Length = 358

 Score =  362 bits (931), Expect = 8e-99,   Method: Composition-based stats.
 Identities = 80/345 (23%), Positives = 148/345 (42%), Gaps = 16/345 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K+    L+A       + G   + A    ++       GV +HG  R   + Q +  G +
Sbjct: 6   KIDAAALRAFTEAAFKAYGFVPDEAAQITDVLMAADLCGVDTHGSQRLEMYRQHINGGFV 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              AQP+ +         D   ++G L A+  M  AI+ A   GIG+V++RN+NH+    
Sbjct: 66  RIGAQPETVFETPVSAVVDGHAAMGQLVARYAMQIAIDKAKQSGIGMVSVRNSNHYGIAA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSY 180
            Y   AA +G +GI  TNS  ++ P   +   +GTNP+ VAIP++P    +D + S+ ++
Sbjct: 126 YYSSMAASQGLVGISMTNSFPIVVPTYGRTPMMGTNPIAVAIPASPTDFSLDAATSVVAF 185

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK------NRRILPMGY-------WKGS 227
           G  EV    G   P+    + +G    +P +I +         + P+G         KG 
Sbjct: 186 GKPEVYLKKGLTAPLGWAINSQGVDETDPQIIVECVRQGLGGGMYPLGGSSELFGSHKGY 245

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           G +++++  +  LS G +     +  +   GI   F A   +   D     +     +  
Sbjct: 246 GYAVLVEFFSACLSQGTTSNHTMK--NGHAGICHHFAAFNPEIFGDAQAIRSHFSAYLQE 303

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + +A   + I + G +      E +++GI +      +++ L
Sbjct: 304 LRESAKAAGQERIYIHGEKEAECCRERKQSGIPILPKTLDEMRRL 348


>UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XHB0_MEIRU
          Length = 336

 Score =  362 bits (930), Expect = 9e-99,   Method: Composition-based stats.
 Identities = 89/327 (27%), Positives = 158/327 (48%), Gaps = 6/327 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  +QL+    ++LI+RG   E A   AE        GV SHG+ R P ++++   G + 
Sbjct: 4   IPVQQLRERVEQILINRGFTLENALPIAESLVLAEMRGVASHGLIRLPIYLERARLGSVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+P  +    A+   DAQ   G  +  K M+ AIE A   G+  V +R ++H+     
Sbjct: 64  PQARPVLLADYPALALLDAQDGHGIPSGLKAMELAIEKAQKVGLAAVGVRRSSHFGLAWY 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           +   A EKG +G+  +N+ A++ PWGA+   +GTNPL V IP+   P   +DM+ S  ++
Sbjct: 124 FVRSAVEKGLVGVALSNADALVAPWGARSRFLGTNPLAVGIPAMEEPPIALDMATSEAAH 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + + +G+ +P++   D EG  T +P        +LP G  KGS +S+++D++   L
Sbjct: 184 GKILLAKSSGKTIPLNWALDAEGRPTDDPDRALAG-ALLPFGGPKGSAISLLIDVLCGPL 242

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                G  +A +  +     G+   F+A+      D      ++   +  V +   A+  
Sbjct: 243 VGALIGPEIAPLYTEPERPQGLGHFFMALNPGVFGDAEQFRKQVDAYIRRVRALPPAENV 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDS 324
             + LPG     L  +  + G+++   
Sbjct: 303 DRVLLPGEREWRLEQKALQEGVSLSPE 329


>UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bacteria
           RepID=C3MH59_RHISN
          Length = 358

 Score =  362 bits (930), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 85/332 (25%), Positives = 158/332 (47%), Gaps = 6/332 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            + ++L A   ++  + G+    A   A    +    G+ SHGV+R P ++++L+ G + 
Sbjct: 7   FSSDELIAFATKIFAATGMADADAATIAGDLVKANLRGIDSHGVSRIPMYVERLQRGLVN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P          GA+   D    +G + + +  + AIELA  +GIGLV +  + H+  G  
Sbjct: 67  PKPAVTVKKVAGAVSLVDGDNGMGFIASHRATEEAIELARANGIGLVGVHRSTHFGMGAL 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y  QA E GYI + +TNS   +P WG +   +G +P+   IP       ++DM+M++ + 
Sbjct: 127 YALQAIEAGYISMIFTNSSPAIPMWGGRTTFLGASPIAAGIPGGKYAPYVMDMAMTVIAR 186

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + +  + G  +      D +GN T +     +    LP G  KGS ++ ++D+++ +L
Sbjct: 187 GKIRLAAMKGETIAEGLALDVDGNPTTDAAKAFEG-VCLPFGGVKGSVLATLMDLMSGVL 245

Query: 241 SDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      +V     D+S+   +  +F AI+ D  +     DA++    + + +  +A   
Sbjct: 246 TGANFGGDVKSLYFDHSEPQNVGHLFFAIKPDLFMSPENFDARMDAFYERIKALPKAAGV 305

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           + I +PG       AE  R GI +  +V A +
Sbjct: 306 EEIMMPGEPEQRREAERLRTGIPITANVIADL 337


>UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria RepID=B4EV95_PROMH
          Length = 349

 Score =  359 bits (923), Expect = 6e-98,   Method: Composition-based stats.
 Identities = 74/336 (22%), Positives = 146/336 (43%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M ++ +QL       L + G++   AD  A++       G++SHG  R   + +++  G 
Sbjct: 1   MIISKQQLHQLIKNKLHNAGLNENHADIVADVLVHADVKGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
                +     +      +D     G++ AK+ M+ AI +A + GI +V +R   H    
Sbjct: 61  TNTHPKFTYQETGPCSAIFDGDNGAGHVAAKQAMEHAINMAQEKGIAVVGVRRIGHSGAL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             +  QA+  G IGI    S  ++ P+G  E   GTNP+  + PS        DM+ ++ 
Sbjct: 121 SYFVEQASASGMIGISLCQSDPMVVPFGGSEVYYGTNPIAFSAPSADDKPITFDMATTVQ 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R     +P     D+ G  T +P  +   + +LP+   KG G+ +++D+++ 
Sbjct: 181 AWGKILDARAKHSDIPDTWAVDEAGKPTCDPFAV---KGLLPIAGPKGYGLMMMVDVLSG 237

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L     G  V+ +  D +    + Q+ I I      D       + ++M  + S + A 
Sbjct: 238 ILLGLPFGKHVSSMYHDLTQGRELGQLHIVINPAFFTDADLFKKHISQVMAELKSIKPAV 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +  PG         + + GI + D ++  + +
Sbjct: 298 GFEQVLYPGENSQLAAQRSEKEGIEIVDEIYHYLNS 333


>UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RKJ3_9CLOT
          Length = 349

 Score =  359 bits (922), Expect = 7e-98,   Method: Composition-based stats.
 Identities = 91/332 (27%), Positives = 155/332 (46%), Gaps = 6/332 (1%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E + A    +    G+    A   AE    T   G+ SHGV R P + +++ NG I  + 
Sbjct: 4   ETVTAFTQELFQKAGMSEPDAKYHAECLVNTNYWGIDSHGVIRVPAYFKRMLNGAINTNP 63

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           Q K +   G +E  D   + G +  +  M+RA++ AA  GI    + N+NH+  G  Y  
Sbjct: 64  QIKVVRGEGCLEVLDVDAAAGFIGGRAGMERAMDHAAVSGIAACGVINSNHFGAGALYAR 123

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGML 183
            AAE+G IGI  TN   ++   GA     G NP+   IP+      ++DMS+S+ + G L
Sbjct: 124 MAAERGMIGIAMTNVKPLIVAPGASVPVTGNNPIAFGIPTYGEFPFVLDMSLSVVAGGKL 183

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
            +      ++P+D   D  G  T +P     +  +LPMG  KG G+S V+D+++ L++ G
Sbjct: 184 TLAIKKKEKIPMDWATDKNGRPTDDPQAAF-DGYLLPMGGHKGLGLSYVVDILSGLITGG 242

Query: 244 ASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
               +   +  +  D       FIA+++ K+I       ++ +  D + +     E   +
Sbjct: 243 VFSKDMKSMYANPKDPSLTGHFFIAMDISKIISKEQMKERMAQFKDQLKATPMWQEGAQM 302

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            LPG        E R+NG+ +  + + ++  L
Sbjct: 303 LLPGEIEYRKEQERRQNGLPIPVTTYEELAEL 334


>UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01XF2_SOLUE
          Length = 344

 Score =  359 bits (922), Expect = 8e-98,   Method: Composition-based stats.
 Identities = 83/330 (25%), Positives = 165/330 (50%), Gaps = 6/330 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + L      +L   GV    A+        +   GV SHG+   P +I QL  G++ 
Sbjct: 4   ISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMD 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+ + I+  G+   +D Q ++G   A+     A+ +A ++G+ LV  R +NH+     
Sbjct: 64  AQAEGRVISESGSCLHFDGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGAAAW 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM 182
           +  +    G IGI   N+  ++PPW  +E R+GTNP+ +++P     ++DM+ +  + G 
Sbjct: 124 WAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPICMSVPG--PWLLDMATTTVAAGK 181

Query: 183 LEVNRLAGRQ-LPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
           +    L  +  +P    FD +G  T +     K   ++P+G +KGSG++++++++ ++LS
Sbjct: 182 IFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKG-MLMPLGGYKGSGLAMMVEILCSVLS 240

Query: 242 DGASVAEVT--QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
            GA   EV   +       +SQ+++AI+V + +      A++++++  + S + A     
Sbjct: 241 GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTE 300

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           + + G     + AE R NGI +    W ++
Sbjct: 301 VMVAGDPEWRMEAERRENGIPIAGGNWDQL 330


>UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CT69_9CLOT
          Length = 349

 Score =  356 bits (914), Expect = 7e-97,   Method: Composition-based stats.
 Identities = 82/331 (24%), Positives = 152/331 (45%), Gaps = 7/331 (2%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           +KA  + +  + G +   A+  A+         VYSHG+ R   + +++ +  I  +  P
Sbjct: 1   MKAWISDIFRAEGFNGGEAELVADSLVDADARSVYSHGIQRVKLYTKRIMSDCINREGCP 60

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +    A    D   ++G    K  M+ AI+ A  +G+  V  R +NH+ R   Y   A
Sbjct: 61  VIVVDRDATAVVDGDNAMGQTVGKFCMELAIQKARQYGVSFVTARGSNHYGRCAYYTRMA 120

Query: 128 AEKGYIGICWT-NSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLE 184
            E   IG   T     +M PWG  + R+G NP   AIP+      ++DM+MS+ + G ++
Sbjct: 121 LEYDMIGFSATIGGGNLMAPWGGTDSRVGNNPYSYAIPAFNHYPVVLDMAMSVVAKGKVD 180

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           V       +P     D  G  T +     K   + P+  +KGSGM+IV+ M+ +++S+GA
Sbjct: 181 VASKTHSPIPDTWALDQNGFPTTDAEEALKG-SLRPIADYKGSGMAIVIGMLCSVISNGA 239

Query: 245 ---SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
              ++  V  D        Q+F+A+++ ++ D      ++ R +D++ ++  A   + + 
Sbjct: 240 IGPTLKRVYGDFDGGLNKGQLFMAVDISRMTDVQVFKERMDRQIDFIKASPAAANTEEVY 299

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           LPG           ++GI     +  +I+ +
Sbjct: 300 LPGELEYRSFDRQMKDGIVYPVEIIQEIREI 330


>UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacteriales
           RepID=Q11YA5_CYTH3
          Length = 381

 Score =  355 bits (912), Expect = 1e-96,   Method: Composition-based stats.
 Identities = 77/345 (22%), Positives = 137/345 (39%), Gaps = 17/345 (4%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
            ++ L A    V ++ G   E A     +       GV SHGV R   +++  E G I  
Sbjct: 28  PYKDLFAFTKNVFLAMGCPQEDAQVATTVLLSADLRGVDSHGVARLTGYVRLWEAGRINA 87

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
               + +    +    D    +G + A   M  AI+ A   G G V+++N+NH+   G +
Sbjct: 88  KPNVRIVHETPSTATVDGDGGLGLVVAPIAMQIAIDKAKQVGSGWVSVKNSNHYGIAGYH 147

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYG 181
              A E   IGI  TN+  ++ P  + +  +GTNP+ VAIP+   P  + D + +  + G
Sbjct: 148 AMMALEHDMIGISMTNASPLVAPTNSLKRLLGTNPIAVAIPAKNEPPMVADFATTTAANG 207

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY------WKGSGMSIVLDM 235
            LE+ +      P+    D  G  T     ++    +LP+G        KG  +  ++D+
Sbjct: 208 KLEILQRKNLDAPLGWIQDKNGVTTPNAHELKDGGALLPLGGDREHGSHKGYCLGSIVDI 267

Query: 236 IATLLSDGASVAEVT--------QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
            + +LS       V           +    GI   F A+ VD           +   +  
Sbjct: 268 FSAVLSGANYGPWVPPFVSFLPVPSDPVGEGIGHFFGAMRVDAFRPADDFKTHMDNWITT 327

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +A  A E + + +PG     +       G+ + + V   ++ +
Sbjct: 328 FRNA-PAVEGEKVLIPGDPEREIQFSRLNEGVPLLEPVVKDLKEV 371


>UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coelomata
           RepID=C3ZIE6_BRAFL
          Length = 360

 Score =  355 bits (911), Expect = 1e-96,   Method: Composition-based stats.
 Identities = 81/329 (24%), Positives = 154/329 (46%), Gaps = 13/329 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  +++ A   R + + G     A A A+        G +SHG+NR   ++Q + +G  +
Sbjct: 11  VPKQEVIAFVERCMGAVGTPGAHASALAQALMTADYRGHFSHGLNRLDMYVQDIRSGMTV 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +         +    +G + +   MD A+  A D GIG V    +NH+   G 
Sbjct: 71  KDGEPTIVNERAGTAFVNGNNLLGPVVSNFCMDLAMRKAKDAGIGWVVACGSNHYSIAGY 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSY 180
           Y  +A ++G +G+ +TN+  ++ P  A++  +GTNP+ VA P       ++DM+ S  + 
Sbjct: 131 YSLKACDQGLVGMSFTNTSPLVVPTRARKGVLGTNPISVAAPGKEGDSFVLDMATSTCAL 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLD 234
           G +E++   G  +P+  G D  G  T +P  + +    + +      G +KG G++++++
Sbjct: 191 GKIELHDRKGLPIPIGWGVDSAGRETTDPKAVLQGGGQMALGGSEVTGGYKGYGLAMMVE 250

Query: 235 MIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   +LS GA    V +   N     + Q F+AI+ +    G     ++Q +MD   + E
Sbjct: 251 LFCVILSGGAFGPNVRRWKTNDRVANLGQCFVAIDPEAFAPG--FHDRMQDMMDCCRNLE 308

Query: 293 RADENQAIRLPGHEFTTLLAE-NRRNGIT 320
            A+    + + G      +A  + + GI 
Sbjct: 309 PAEGETEVLVAGDPERKHMAMCDAQGGIP 337


>UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunction enzyme n=3
           Tax=Candidatus Pelagibacter RepID=Q1V2K0_PELUB
          Length = 336

 Score =  354 bits (910), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 82/331 (24%), Positives = 150/331 (45%), Gaps = 7/331 (2%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           +LK     + I   ++ + A  CAE        G  SHG++R   +  ++    I P A+
Sbjct: 5   KLKTIIKDIFIKYKLNKDHATICAEALINAELVGAPSHGLSRLKMYCDRISKKVINPKAK 64

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
            K      +I   D   SIG + A   +  AI  A   GIGLVA++N+ H+   G Y  Q
Sbjct: 65  IKVKKISQSIAHVDGNNSIGFVAADTAIKTAINNAKKTGIGLVAVKNSGHYGLSGYYAEQ 124

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLE 184
           A +KG + + +TN+   + P GA +   GTNP+    P+      ++D S+SM + G + 
Sbjct: 125 AVKKGLMVMVFTNAPPAVAPHGALKSLFGTNPICFGTPTGSKVPFILDTSISMINRGKIR 184

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           V    G ++P     D  G  T +P    +  + LP+  ++GSG++ ++D+++ +L+ G 
Sbjct: 185 VAAREGTKIPEGVALDKFGKPTTDPKKALEGVQ-LPIAGFRGSGLAWMVDILSGVLTGGN 243

Query: 245 SVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
               V     D S    I  +F  ++ +  + G + + +++  +  +    +    + I 
Sbjct: 244 HAGRVKDPFTDFSGPQNIGHLFFVLKPNLFV-GNSFNKRIKDNIKTIKKLPKIKGVKEIL 302

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            PG         N +  I +  +V   ++ L
Sbjct: 303 YPGQSKFNRFKSNLKKEINISKAVLKDLEYL 333


>UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2
          Length = 344

 Score =  354 bits (908), Expect = 3e-96,   Method: Composition-based stats.
 Identities = 79/336 (23%), Positives = 155/336 (46%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+   + L A    +L   G D  +A A A         GV SHG+ R P ++++LE G 
Sbjct: 1   MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P      +   G +   D +   G   A K ++ A  LA  HG+G V +R + H+   
Sbjct: 61  VNPSPTLP-LEERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMA 119

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y  + A+ G++ +  TN+   + P+G +E  +GTNPL  A P+    +V D++ S  +
Sbjct: 120 GLYAEKLAQAGFLALVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESA 179

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + + R  G ++P   G D EGN T +P  +     + P+G  KG  +++++++++ +
Sbjct: 180 MGKVFLAREKGERIPPSWGVDREGNPTDDPHRVY---ALRPLGGPKGYALALLVEVLSGV 236

Query: 240 LSDGA---SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+       +  +  +      +    +A++  + +       ++  +   + +   A  
Sbjct: 237 LTGAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVGKEAFLERMGALWQALKATPPAPG 296

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ + LPG             G+ + + V A+++AL
Sbjct: 297 HEEVFLPGELEARRRERALAEGMALPERVVAELKAL 332


>UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba RepID=C4M213_ENTHI
          Length = 365

 Score =  353 bits (906), Expect = 6e-96,   Method: Composition-based stats.
 Identities = 81/348 (23%), Positives = 148/348 (42%), Gaps = 17/348 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFP-RFIQQLENGD 60
            V+ + +K    +VL+  G D E A    +        G+ +HG+ RF   +I +++ G 
Sbjct: 8   NVSIDTIKEFMYQVLLKVGSDEENARMVRDTLIAADLRGMDTHGIQRFKTVYIDRIKKGM 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+P  I         D     G++     M  AIE A  +G+G+V +RN+ H+   
Sbjct: 68  INPTAKPSIIRETSTTCVLDGNNGFGHVNGTIGMKMAIEKAKKYGMGMVVVRNSTHFGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   AA++G IGIC TN+ + +      E  +GTNPL + IPS        D + S+ 
Sbjct: 128 GYYSLLAAQEGCIGICGTNARSSVAATFGDEPILGTNPLAIGIPSDEAFPYCFDGATSIS 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNR-----RILPMGY-------WKG 226
             G  E     G+ +         G   ++P  + +N       + P+G         KG
Sbjct: 188 PTGRFEKYVRMGKTVDKSWASMKGGKPIEDPKELLENYPKGKAYLHPLGGSDEVSGSHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
             +S  ++++++ LS    +  +   ++ S ++ +   FIAI V+   D       +  I
Sbjct: 248 YCLSEFVEIMSSCLSIANFLNHIEEEKEKSGKFSLGHFFIAINVECFRDLNEFKKNVGDI 307

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + + ++   +  I   G +      + R+ G  +      +++ L
Sbjct: 308 NRTLRNTDKLPGHDRIYTAGEKEYETEQKRRKFGDDLPLVTINEMKEL 355


>UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C5R1_9PLAN
          Length = 371

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 148/335 (44%), Gaps = 8/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E LK    ++L+   +    A   A+    +   G+ SHGV R P +++++    I 
Sbjct: 11  IEPESLKEFCYQLLLQANLTGHDAGLVADTLVESNLRGIDSHGVARLPHYLERIRQQSIQ 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P  + +      A+ + D    +G L   K  D A+ELA D G G V++ N++H      
Sbjct: 71  PRPEMQWEPLGDAVGRVDGDHGLGQLAMVKAADHAVELARDSGAGWVSICNSSHCGALAY 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSY 180
           YG + AE G IG  +T+   ++ P GA E   GTNP+ +  P        +DM+ S+  +
Sbjct: 131 YGLRIAEAGMIGFAFTHVDPMVTPHGAAEPFCGTNPICMTAPGKEGKSLCLDMATSITPW 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +      G  +P D   D  G  T +P  +     + P G +KGSG+ +++D++  LL
Sbjct: 191 NTIANAATEGVSIPGDWALDANGRGTTDPNEVV---ALFPFGGFKGSGLGLMIDVLCALL 247

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                G  + ++  D +    +  +  AI++ +  +  T   +++ ++    + +   E 
Sbjct: 248 GGAPIGPDIPKMYGDLTQRRLLGGMVGAIDISRFTEVETFQDRIEELIQRWGAVKPLKEG 307

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  PG        E  ++GI V   +  +   L
Sbjct: 308 GKVYYPGEPEALTRVERLQSGIPVGLRLINQFNEL 342


>UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria RepID=ALLD_ECOLI
          Length = 349

 Score =  348 bits (894), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 76/334 (22%), Positives = 136/334 (40%), Gaps = 8/334 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L       L   G+  E A   AE+       G++SHG  R   + +++  G 
Sbjct: 1   MKISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
              + + +   +        A  + G + AK  M+ AI+ A  +G+ +V +    H    
Sbjct: 61  TNREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAI 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
             +  QAA  G+IGI    S  ++ P+G  E   GTNPL  A P     I   DM+ ++ 
Sbjct: 121 SYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATTVQ 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R     +P     D  G  T +P  +     +LP    KG G+ +++D+++ 
Sbjct: 181 AWGKVLDARSRNMSIPDTWAVDKNGVPTTDPFAVH---ALLPAAGPKGYGLMMMIDVLSG 237

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L     G  V+ +  D      + Q+ I I  +           L + M  + +   A 
Sbjct: 238 VLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMRELNAITPAP 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
               +  PG +      +    GI + D ++  +
Sbjct: 298 GFNQVYYPGQDQDIKQRKAAVEGIEIVDDIYQYL 331


>UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizobium medicae WSM419
           RepID=A6ULS2_SINMW
          Length = 348

 Score =  347 bits (891), Expect = 3e-94,   Method: Composition-based stats.
 Identities = 84/336 (25%), Positives = 149/336 (44%), Gaps = 6/336 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E L+     VL + G+  + A   A+        GV SHGV R   ++ ++  G 
Sbjct: 5   VILEAEALRGFTEDVLKAAGMRPQPAATVADTLVYADLRGVSSHGVARLGSYLDRIRAGV 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  D Q + I    A    DA    G +     M+ AIE A   G  ++ + N+NH+   
Sbjct: 65  MEIDPQMRLIREAPASGLLDAGNGFGQIAGMTAMEIAIEKAKSAGSAVIGIANSNHFGVA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             +  +A   G +GI  TNS   M  +  +   IGTNP+   IP+      ++DMS S+ 
Sbjct: 125 AYFAERATRAGMVGIVLTNSSPAMTAFNTRIPLIGTNPIAFGIPAGAERPIILDMSTSLV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +  L G+ +P+   +DD G  T++     K   + P+G  KG+G+S+++D++  
Sbjct: 185 ARGKIRLASLTGKPIPLGWAYDDRGLSTEDAHAALKG-SLAPIGGPKGAGLSLIIDLLTG 243

Query: 239 LLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +L+      EV    D S       + IA +V + I      + +  ++  + +   AD 
Sbjct: 244 VLTGTGLTGEVKNITDISGPSRTGHLMIAFDVSRFISPELFKSSVDSVVANIKAMPSADG 303

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + +PG           R+GI V   +   ++ L
Sbjct: 304 G-PVFMPGEMEAIGAERRARDGIGVPRDIVDTLRGL 338


>UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteria
           RepID=A8RPZ9_9CLOT
          Length = 339

 Score =  346 bits (889), Expect = 6e-94,   Method: Composition-based stats.
 Identities = 145/336 (43%), Positives = 207/336 (61%), Gaps = 4/336 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++TF+++K+   RVL+  G+  E A+ CA +   TT  GVYSHG NR  RF+  ++ G 
Sbjct: 4   MRLTFDEIKSEIKRVLVKYGMSEEKAETCARIHTETTYDGVYSHGTNRVARFVNYIQKGW 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P      GA+  ++     G L A    DRA+ELA  +GIG+V +RN  HWMRG
Sbjct: 64  VDVNAEPSLEREFGALRVYNGNMGPGVLNALYCADRAMELADQYGIGMVGIRNTTHWMRG 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSM 177
           G+YG  AA KGY  I WTN+ + MPPWG +ECR+G NP ++A+PS        +DM+MS 
Sbjct: 124 GTYGLYAARKGYAAIMWTNTESCMPPWGGRECRLGNNPFVMAVPSADGGEPLQLDMAMSQ 183

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
           +SYG L+V RLAG +LP  GGFDDEGNLT +PG IE++RR+LP+GYWKGS  S +LD++ 
Sbjct: 184 YSYGKLQVTRLAGEKLPYPGGFDDEGNLTDDPGAIEQSRRVLPVGYWKGSAFSFMLDILG 243

Query: 238 TLLSDGASVAEVTQDNSDEY-GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++L+DG   A + Q       G SQ+ I ++  +          +   + YV S+  ++E
Sbjct: 244 SVLTDGIGAAGMDQKGYGSCGGCSQVMIVVDPGRTTTDAHMKEIVDTAVLYVKSSAPSEE 303

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             ++R PG        E+ R GI VDD VW +IQ+L
Sbjct: 304 GGSVRAPGQGSARFHEEHDRLGIYVDDDVWKEIQSL 339


>UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesenteroides ATCC 33313
           RepID=C5RAQ8_WEIPA
          Length = 363

 Score =  345 bits (887), Expect = 1e-93,   Method: Composition-based stats.
 Identities = 92/348 (26%), Positives = 155/348 (44%), Gaps = 19/348 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   +++ A  N++  + G   E +   A+    T   G+ SHGV R   + + ++NG I
Sbjct: 4   RYDSQKMNALVNKIYQAYGFSKENSQKIADALIYTDLHGITSHGVQRLALYDRFIQNGKI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D+ P+           DA    G L     M  AIE A  HG+G+V  + + H+   G
Sbjct: 64  RIDSHPEIEKETDVSAVIDANFGSGQLNGMYSMGVAIEKAKAHGVGIVTTKRSGHYGIAG 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSY 180
            Y   AAE+G IG+   NS   M P  AK+  IGTNP+  A+P+ P   + D + ++   
Sbjct: 124 YYANLAAEQGLIGMSSCNSRPGMIPTNAKKAFIGTNPIAFAMPAKPHNFIFDAATTVVPQ 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLT---KEPGVI------EKNRRILPM-------GYW 224
           G +EV R   + LP      +         +   +      E N  I P+       G  
Sbjct: 184 GKIEVYRKQEKDLPALWVAKEGNQPVYDHTDTATLDSLRDPEANVGIAPLGGITEETGGH 243

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           KG G+ I++++  ++LS G + AE++  +  E G  Q FIAI+     D      K  R 
Sbjct: 244 KGYGLGIMVEVFTSILSLGNTSAEISASD-VETGPCQSFIAIDPAIFGDSEKIIDKFSRY 302

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ +         + + + G +      + ++NGI +DD    +I+A+
Sbjct: 303 LEDLRQLTAVPG-KEVYVHGDKEQLAYQDRKKNGIEIDDKTIMEIKAI 349


>UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacillus
           RepID=C6VNL4_LACPJ
          Length = 362

 Score =  344 bits (884), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 78/350 (22%), Positives = 152/350 (43%), Gaps = 24/350 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E  +     V  ++   ++     A+        G+ SHG+ R   + + +++  
Sbjct: 1   MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  QPK +         DA +S+G + +   M++ IE     G+ L  +RN+NH+   
Sbjct: 61  LEPTNQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y   A + G IGI  TN+  ++ P  A E  +G+N L    P+ P   + D + ++ S
Sbjct: 121 GYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE------------KNRRILPMGY---- 223
            G ++V    G Q+P D   D+   +  +   +E                +L +G     
Sbjct: 181 SGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLAKIAFSENRPGGGVLTLGGQQEV 240

Query: 224 ---WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S++++++  +L+ G+  A+    N+ ++  SQ F+ I      D     A 
Sbjct: 241 NSNYKGFGNSLIIELLTGILAQGSLSADT---NTGKHDFSQFFMTINPALFGDPEVLKAN 297

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  + D +   +     + I +PG        EN   G+++D     ++Q
Sbjct: 298 VTTMFDRIRHLKHLPGTK-IMIPGDREYRHYDENLVQGVSIDPQTLTEMQ 346


>UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydroxyacid
           dehydrogenase) n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RN53_9RICK
          Length = 349

 Score =  344 bits (884), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 82/337 (24%), Positives = 150/337 (44%), Gaps = 7/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K+   +LK+    +L   G++S  A   +EM  R  E GV+SHG+ R P ++Q+L     
Sbjct: 4   KIKIYKLKSLTQAILKKVGLNSINAKVVSEMLVRADERGVWSHGIVRLPVYVQRLNKNAA 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P  + K      +    +    +G ++A + M + I+LA  +GIGLV + N+NH+    
Sbjct: 64  NPKPKLKFKKISQSAFHLNGDNGLGFISANEGMKKCIQLAKKNGIGLVGISNSNHFGMAA 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMF 178
           +Y   AA+   I   +TN+   +PP GA     GT+P   + P+       ++DM+ S  
Sbjct: 124 NYLELAAKNNCISWVFTNASKALPPHGAMAPFFGTSPFAFSCPTKNKNKPFILDMASSSV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L+       ++P     D  G  T +     +   +LP G  KG+G+S ++D++A 
Sbjct: 184 ARGKLKFAAQNNIKIPFGYALDKFGKPTNDGQKAFEG-IMLPFGGMKGAGLSWMMDIVAG 242

Query: 239 LLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           + +      +V     D S    +  + I +  +          K++  +  V   ++A 
Sbjct: 243 IFTGANHSGKVKNAINDFSGPANVGHLMICMRTNLFQSHKNFIKKIEYGIKQVKQLKKAK 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + I  PG          +R+GI +      +++ L
Sbjct: 303 GFKKILHPGEPEYLNEMRLKRSGINLSKETVIELKKL 339


>UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococcus prevotii DSM
           20548 RepID=C7RGK9_ANAPD
          Length = 337

 Score =  344 bits (883), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 136/334 (40%), Positives = 207/334 (61%), Gaps = 2/334 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVT+++LK      L + GV  E ++  A++ A +T  GV SHG+NR PR I  +  G 
Sbjct: 1   MKVTYDKLKNTIKNALKASGVSEEKSELMAKVHAESTLKGVNSHGLNRIPRLIDFINKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+ + + S G++E ++     G + A K  DRA ELA +HGIG+V LRN  HWMRG
Sbjct: 61  VDINAEMELVKSFGSVENYEGNLGFGVINALKASDRAAELAKEHGIGMVTLRNTTHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G+Y    A+KG IG+CWTN+ ++MP WG+ E  +G NP+ ++IPS    + +DM++S++S
Sbjct: 121 GAYSENIADKGMIGMCWTNTESLMPVWGSDEISLGNNPIGISIPSESGNICLDMAISLYS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE  RL G +LP  GGFD  GNLT +P +IE+++ +LP+GYWKGSG+ I LD +A L
Sbjct: 181 YGKLETTRLKGEKLPYPGGFDKGGNLTDDPKLIEESQNLLPVGYWKGSGLGICLDTMAAL 240

Query: 240 LSDGASVAEV-TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           LS+G S  ++  +D  +    SQIFIA+  +        +  +++I + V SA   +   
Sbjct: 241 LSNGLSTYDMDDRDGFNCTSCSQIFIAMNPEAFSTKEENEKTIRKIKERVKSAHPTNPGL 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + R PG    T   +  R GI +DD ++ K+++L
Sbjct: 301 SPRYPGLGLYTRKEKGLREGIEIDDKIFKKVESL 334


>UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PC96_9FIRM
          Length = 353

 Score =  344 bits (883), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 95/337 (28%), Positives = 149/337 (44%), Gaps = 7/337 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E LKA     L   G++S  A  CAE  A T   G +SHG      +I++   G + 
Sbjct: 5   IALEDLKAFCTAALEHEGMESGDARRCAEALAETDAYGTHSHGTKNLHNYIKKFRAGGMD 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A  K +T   A    DAQ  +G   + + M+ AIE A   G+ LV +  +NH+   G 
Sbjct: 65  IHAALKVLTDGPAYALLDAQNGMGECASYRAMELAIEKARKSGVALVTVCRSNHFGAAGF 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           Y   AA+ G +G+C +N    M   GAK   +G NPL  A P  STP   +D++MS  + 
Sbjct: 125 YANMAAKAGMLGLCVSNVDPNMTAPGAKGMLLGNNPLAYAAPAKSTPSIFLDIAMSNVAS 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +   R  GRQ+P     D +G  T +P    +   + PM   KG G+SI++D++   L
Sbjct: 185 LKVVQARKDGRQIPDSWIVDKDGLPTTDPSHYPEEGAMQPMAAHKGYGLSILVDLLTGAL 244

Query: 241 SDGASVAEVTQ-----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           ++ A+           +      +S  F+ +  +          + +++   +  A +A 
Sbjct: 245 ANAATSMSGEIVSWCFELDKPNNVSHAFLVVNPEMFGGAQAYVQQNEQMAAALRKAPKAQ 304

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  I  PG       A     GI + D V   I+AL
Sbjct: 305 GSTRIYTPGEIEWERYARAVSEGIKLPDDVAGSIEAL 341


>UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SBU9_9ACTO
          Length = 353

 Score =  344 bits (882), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 82/336 (24%), Positives = 156/336 (46%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  + L+A    VL + GV  + A   A+   +    G  SHG+ R P +  +L +G +
Sbjct: 5   RIEPKLLRAFGTGVLTALGVPGDDAALVADSLVQADLWGHQSHGLLRLPWYGARLRSGAM 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++  G +   D +  IG +  ++    A+E A  HG+G+V +RN+NH+    
Sbjct: 65  RAVPEPAVLSDTGPLVLLDGRDGIGQVLTERARRLAVERARTHGVGVVGVRNSNHFGTAM 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM--VDMSMSMFS 179
            +  +AA  G + +  TN+   M PWG +E R+GTNP  +A P    T+  +D++ +  +
Sbjct: 125 WFTRRAAHDGVVAVLTTNASPAMAPWGGREKRVGTNPWSIAAPGPDGTVLALDIANTAVA 184

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + + +  G  +P       +G  T +P        +LPM   KG  ++ ++D+++  
Sbjct: 185 RGKIHLAKNRGEPIPDTWALTADGAPTTDPEEGVLG-VLLPMAGHKGYAIAFMMDVLSGA 243

Query: 240 LSDGA--SVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A  +      +     G   +F+A++ D   D    +A++++++D V S   A   
Sbjct: 244 LTGSAVGTGVHGPYEPDARSGCGHLFLALDPDAFGDRAGYEARVRQLVDEVASVPLAQGF 303

Query: 298 QAIRLPGHEFTTLLAENR-RNGITVDDSVWAKIQAL 332
             +  PG       A N    G+ +     A ++ L
Sbjct: 304 DGVLHPGQVEDRAEAANLAAGGVVLARDSLAGLRRL 339


>UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62_BRAJA
          Length = 350

 Score =  344 bits (882), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 87/338 (25%), Positives = 144/338 (42%), Gaps = 12/338 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++L      +L + G   E ADA A        +G  SHGV   P +I +++ G I+
Sbjct: 4   VRADRLTRISAALLQAAGASQEEADAVATGCVNANLAGHDSHGVIAVPTYIDRIKAGHIV 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A    I         D     G     K M   IE A    +    +   +H  R  +
Sbjct: 64  PGATWTIIQESPTTTVIDGHWGFGFHVNAKAMALTIEKAKTANVAACTVFRQSHVGRLAA 123

Query: 123 YGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSM 177
           Y   A  +G IGI   +   S   + P+G KE R+GTNP+ +A+PS       +DM+ S 
Sbjct: 124 YPLMAMREGMIGIATADSGRSPKHVAPFGGKEARLGTNPISIAVPSDLDAPFYLDMATSA 183

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG---YWKGSGMSIVLD 234
            + G +++    G ++P     D EG  T +P    K   +LP+G    +KGSG++ +++
Sbjct: 184 VAAGKIQLAVARGDKIPTGWIIDAEGRHTNDPTQYRKGGALLPLGGTEGYKGSGLAAMVE 243

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           ++  LL+      E T  ++D            V           ++     Y+ S   +
Sbjct: 244 VLCGLLTGLGFGVEPTGRHND----GCFMAVFNVAAFRPLKEFKREVAEFARYLKSTPPS 299

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +  +  PG        +  R+GI V+D+ W K++AL
Sbjct: 300 EGSTGVYYPGEIEGVREQQRLRDGIEVEDATWDKLRAL 337


>UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN9_DROME
          Length = 503

 Score =  344 bits (882), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 77/328 (23%), Positives = 143/328 (43%), Gaps = 14/328 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +        +  V    A+A A++       G +SHG+NR   +I  L      
Sbjct: 151 VAVAESRRFMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTD 210

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK +    A    D    +G +     MD AI+ A   G+G V  + +NH+   G 
Sbjct: 211 GAAVPKILKETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGW 270

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           Y  +A ++G +G+  TN+  +M P  AKE  +GTNPL +   +T     ++DM+ +  + 
Sbjct: 271 YAIRAMDQGLVGMSMTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAV 330

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLD 234
           G +E+ R  G  LP     D  G +T +  +      ++P+G       +KG G+  ++D
Sbjct: 331 GKIEIQRRKGAPLPDGWAQDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVD 390

Query: 235 MIATLLSDGASVAEVTQ----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +++ ++S      +V +           + Q+FIA++ +     P  + ++      +  
Sbjct: 391 ILSGVMSGANYSTQVRKWTHAGADSAADLGQVFIAVDPNCF--APNFEERMADFNSRLRG 448

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNG 318
           A   D ++ + L G +    +A+    G
Sbjct: 449 ATPTDPSKPVLLAGDKEKKGMADVDAAG 476


>UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyces
           RepID=C9Z6D5_STRSW
          Length = 356

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 82/334 (24%), Positives = 144/334 (43%), Gaps = 5/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L         + GV +  A   A+        G  SHG+ R P ++ +L +G   
Sbjct: 5   VGSADLLNFAAATAEAHGVPAVDARLLADTLVTAELWGHPSHGMLRLPWYLDRLASGATT 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A P  +T  GA+   D    +G +   + +   +E A  HGI  VA+RN+ H+     
Sbjct: 65  AVAAPVTVTDSGAVLVVDGCDGLGQVLTSRAVTWGVERARRHGISAVAVRNSGHFGTAAY 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           +  +AAE+G + +  TN+   M PWG +E  +GTNP  +A P       ++D++ +  + 
Sbjct: 125 FTRKAAEQGCVALLATNASPAMAPWGGREKSVGTNPWSIAAPGGRHGTVVMDIANTAVAR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   R  G  +P     D  G  T +P    +   ILPM   KG  +S + D++A +L
Sbjct: 185 GKIYHARERGEAIPDGWAADAGGVPTNDPRRAIEG-LILPMAGHKGYAISFMFDVLAGVL 243

Query: 241 SDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           +  A    V      +   G+  + I +++  + D    + +++ +++   +   A    
Sbjct: 244 TGSAFGTAVVGPYQPTGRSGVGHLLICVDIAAMADPAEFETRMEALIEETKAVPAAPGTA 303

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            I +PG          R  GIT+ D  W  +  +
Sbjct: 304 EIFVPGEPEARTAERLRSEGITLTDDTWTSLGRI 337


>UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YDL3_MOBAS
          Length = 352

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 74/336 (22%), Positives = 145/336 (43%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +   L+   N +  + G+  + A    ++       G  SHG+ R P + +++  G +
Sbjct: 3   RFSLATLRPFANALFEASGLSQDHAALVTDVLIHADLRGHGSHGLTRIPIYAERIAAGAV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                 +      A  Q D     G + +   ++ AI  A + G+ + A+  +NH   G 
Sbjct: 63  NARPDIRFERPAPAFLQVDGDNGPGPVVSDAAVEAAIATAKEQGVCVAAVARSNHNGSGS 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
            Y  +A   G I +  TN+   M  +G ++  IGTNP+    P       M+DM+ S+ +
Sbjct: 123 FYVEKAVAAGCIALAMTNAPPSMAVFGGRQAVIGTNPVTFGTPVDGGTPIMMDMATSVVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G  +P     D +G  T +    E+   +LP+   KGS ++I+++++  +
Sbjct: 183 RGKVVEAAKRGEAIPEGWALDADGKPTCDGRAAERG-VVLPLSGPKGSALAIMVEVLCGV 241

Query: 240 LSDG---ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           LS G    S+  +  D      I    + I+V ++       A+++ ++  +  +  A+ 
Sbjct: 242 LSGGRFAGSLGNLYSDFETPQDIGHFMLLIDVSRIHASSGYAARVRDLVLELKDSATAEG 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              I++PG         N   GI + D+V A + A+
Sbjct: 302 FSEIKMPGEVEMERARSNSAEGIDLPDNVVADLNAI 337


>UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Proteobacteria
           RepID=YBIC_ECOLI
          Length = 361

 Score =  342 bits (877), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 144/335 (42%), Gaps = 9/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   + L +    V    G + + A   A+       +G  SHG+   P +++    G +
Sbjct: 6   RFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHL 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             +   K +   GA    D  R+ G + A + M   IE A  HGI  VAL N++H  R G
Sbjct: 66  QINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIG 125

Query: 122 SYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
            +  Q A  G++ I + +   I ++ P+  ++ R GTNP  V  P       ++D + S 
Sbjct: 126 YWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSA 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIVLDM 235
            ++G   V    G  +P     D  G  T  P V++++    +L     KG  ++ + ++
Sbjct: 186 IAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEI 245

Query: 236 IATLLSDGASVAEVTQDNSDEYGI-SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           +   LS G +  + T   S +  +     I I  +     P  +A+ +   ++V ++   
Sbjct: 246 LGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFG-APDCNAQTEAFAEWVKASPH- 303

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           D+++ I LPG        E ++ GI +D   W  I
Sbjct: 304 DDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAI 338


>UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobacillus plantarum
           RepID=C6VL76_LACPJ
          Length = 362

 Score =  341 bits (876), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 90/349 (25%), Positives = 150/349 (42%), Gaps = 21/349 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   ++++     +    G   E +   A M   T   G+ SHGV R   +   + NG I
Sbjct: 4   RYNSKKIEQLIYNIYKGYGFTEEESQEVAHMLIYTDLIGIESHGVQRMIMYDDFIRNGKI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P+ +         DA   +G L     M  AIE A  HGIG+V  RN+ H+   G
Sbjct: 64  RVHNRPEVVKETDVSAVVDAHFGLGQLNGIYSMRLAIEKAKQHGIGIVTTRNSGHYGIAG 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   AAE+G IG+   NS + M P  A +  +GTNP+  A+P+ P   + D + +    
Sbjct: 124 YYANMAAEEGLIGLSSCNSRSAMLPTHATKALVGTNPIAFAMPANPNTFIFDAATTTVPQ 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEG-------NLTKEPGV---IEKNRRILPMGY------- 223
           G +EV R  G+ +P       +G       N TK+      ++ N  + P+G        
Sbjct: 184 GKIEVYRKLGKDMPALW-VAKDGETPVNSHNDTKDLDALRDLDSNVGLAPLGGVTEDTGS 242

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KG G+ +++++   +LS G +  E+T D+    G  Q F+AI+     D     AK   
Sbjct: 243 HKGFGLGVIVEVFTAILSMGNTSNEITPDDLS-VGPCQSFVAIDPSIFGDKDAIIAKFSA 301

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  +         + + + G +      +   NGI +DD   A++  +
Sbjct: 302 YLQAIRDLPSVPG-KPVIVAGDKEAAAYQDRSANGIEIDDKTLAEVTGI 349


>UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacillus
           RepID=C9M4P7_LACHE
          Length = 361

 Score =  341 bits (876), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 73/352 (20%), Positives = 143/352 (40%), Gaps = 23/352 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++    K    +V  +R          A+        G+ SHG+ R   +   ++   
Sbjct: 1   MRISSLSEKEFLEKVFAARQFSKSDGALLADTLVDADLRGISSHGIQRLAWYTSMIKEHI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  + K I         DA +++G +       + I+     G+ +  +RN+NH+   
Sbjct: 61  IEPQNKLKVIKETPTSLLIDANKNMGQIATAFAEKQLIKKTQKLGLSVAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y   AA++G IGI  TN+  ++ P  A E  +G+N      P+ P   + D + S+ S
Sbjct: 121 GYYARMAAKQGLIGIALTNTRPLVVPPNATEAFLGSNAFAFTFPAEPHPFVFDGATSIVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY---------------- 223
            G ++V     + +P D   DD   +  +   +E N   +                    
Sbjct: 181 SGKIQVLAKNNQPIPGDWAVDDHRRVMHDAQKVEDNLAKVAFTEKQPGGGVLTLGGLLQS 240

Query: 224 ---WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S+V++++  +L+ G+  A+  +     +  SQ  + I  +   +       
Sbjct: 241 NSNYKGFGNSLVVELLTGILAQGSISADTNKPGH--HDFSQFLLTINPELFGNLDDLKKS 298

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + + D +   +     + I +PG       AEN + G+ +DD   A+++ +
Sbjct: 299 AEEMFDRLRHLKHLPGTE-IMIPGDREYRRYAENLKQGVVIDDKTVAELKTI 349


>UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. GAI101
           RepID=B7RGK0_9RHOB
          Length = 361

 Score =  341 bits (876), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 96/339 (28%), Positives = 157/339 (46%), Gaps = 9/339 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L A    +LI  G   + A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MKISAEHLTALATSILIHAGGQPDAAQRIATRLVSANLTGHDSHGVGMIPAYVDGIFAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PDA    +   G     D QR  G++ A++ MD AI+ A  +   +++LRN+ H  R 
Sbjct: 61  LDPDASVDVVQDKGPFLLVDGQRGFGHIVAEQAMDLAIQRARTNHFAVLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G +G  AAE G+I I + N   S  ++ P+G  + R  TNP   AIP+T   P+ ++DM+
Sbjct: 121 GDWGAMAAEAGFICILYANVQSSRPLVAPFGGSDGRFVTNPYCTAIPATDTHPMFLLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  + G   V  L+G+Q+P     D +GN T +P V+  +    +   G  KG G++++
Sbjct: 181 TSKIAMGKARVAHLSGKQVPEGSLIDAQGNPTTDPSVMFDDAGGALTTFGDHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            D++    S G +     +        + + I I+ D           + R  D+V ++ 
Sbjct: 241 GDILGGSFSGGGAYLPEREVPLSITN-NMLAILIDPDVFGMAQAFGVDMDRYTDWVKASP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A    A++LPG        + + NGI VD    A +  
Sbjct: 300 PAPGVDAVQLPGDPERRSAQDRQANGIFVDAGTRAHLVE 338


>UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp. CCS1
           RepID=Q28JS2_JANSC
          Length = 362

 Score =  341 bits (875), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 92/335 (27%), Positives = 153/335 (45%), Gaps = 6/335 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHG--VNRFPRFIQQLENG 59
            V  EQL+        + G+  E A   A     +        G  V R  R+ +++ NG
Sbjct: 9   NVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNG 68

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
           ++ P A    +    A+   DA   IG + A K M  AI+ A + GIG V +RN+ H+  
Sbjct: 69  EVNPRAGWSIVKEGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGS 128

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
              +  QA E G IG+ +TN+   M PWG +E   GTNP  +A PS     T++D++++ 
Sbjct: 129 SAVHACQALEHGCIGVAFTNAGPEMAPWGGREGVTGTNPWSIAAPSDQGFPTVLDIAITT 188

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
              GM+      G+++P+D     +G+ T +P    K   +L +G  KG G++ + + + 
Sbjct: 189 AGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGP-LLGIGGHKGYGLAFMTEALT 247

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            +LS G        D   +  +S  F AI+++  +D      ++   +    +       
Sbjct: 248 GVLSGGGFGLTPYSD-PQKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGF 306

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I +PG +     A    NG+ +DD V A +QAL
Sbjct: 307 DEILVPGEQEARRTAAKAENGVPIDDVVLADMQAL 341


>UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=Amycolatopsis
           orientalis RepID=Q9XBD3_AMYOR
          Length = 337

 Score =  341 bits (875), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 86/335 (25%), Positives = 151/335 (45%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L+A   R+L++ G  +  A+  A     +   G  SHGV R   +++++  G 
Sbjct: 1   MNVQAAELEALATRILVAAGSSTVDAETVARSLVGSDLLGHDSHGVRRVIDYVKRIHTGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+PK  T+         +R+ G L  ++ +   + L    G G+  +R  NH  R 
Sbjct: 61  IDPRAEPKAETTRPGTVVVHGRRAFGQLAVRRAVRELLSLVPHQGSGVAVVRECNHIGRL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI---PSTPITMVDMSMSM 177
           G Y    A++  IG+ + N+   + P+G +E R+GTNPL  A+   P  P  ++D + S 
Sbjct: 121 GEYVAMLADQDLIGLAFGNADPTVAPYGGRERRLGTNPLAWAVPRGPGQPPIVMDWATSG 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G L V R  G Q+      D  G  +  P    +   +LP G  KG G+S++++++ 
Sbjct: 181 IAEGKLRVARDRGEQVAEGLVLDAAGRPSTTPADFYQGGALLPFGGHKGYGLSVLIEIVG 240

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L     S   +        G   + +A ++   +  P   A+ +R    +     A+  
Sbjct: 241 GL----LSGIGIGSMPGFREGWGTVLVAFDIAAFLPVPEFRAQTERFCQALAETPLAEGA 296

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +PG     +  E  R+GI V  + W ++ AL
Sbjct: 297 SEVLVPGEPEERIRLERARDGIPVTANTWRELNAL 331


>UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspira
           RepID=C0R1X7_BRAHW
          Length = 334

 Score =  340 bits (874), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 72/333 (21%), Positives = 139/333 (41%), Gaps = 7/333 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +KV  ++L  A        GV +E A    ++       G++SHGV R   +I ++++G 
Sbjct: 2   IKVNVKELMDAVYNKFKMAGVSNEQAGIVTDVLIYADIRGIHSHGVLRVEHYIDRIKSGG 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +++        +    DA    G++  +  M+ A+E     GI L+ ++N +H    
Sbjct: 62  INLNSEFHIEEKRPSFALMDADGGFGHVATQYAMEWALETVEKQGIALIGIKNNSHAGAL 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y   A ++  + +   N+   + P+G K    GTNP+    P     ++ DM+ S  S
Sbjct: 122 GYYNKMAIDQNKVSLIMVNTDPCVIPFGGKRSFFGTNPISYGFPGKKDFILGDMATSEVS 181

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R     +P+  G D+ GN +  P  I   + ++P G  KG  +  +++    L
Sbjct: 182 LGRIFTARENNETVPMHWGVDENGNPSSNPNEI---KYVVPFGGVKGYLIMTMVEAFTGL 238

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       ++ ++  D   +  +S   + ++     D  T    +Q  +D +       E
Sbjct: 239 LIGQVYCNNLVKMYGDMDKKRNLSTFMLVVDPAVYNDLDTYLNTVQSFIDDIRKEPALKE 298

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              I +PG           + GI + + ++  I
Sbjct: 299 GSTISIPGERKEACSKVYLKEGIPLPEHIYKYI 331


>UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836
           RepID=D2Q379_9ACTO
          Length = 362

 Score =  339 bits (870), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 86/327 (26%), Positives = 156/327 (47%), Gaps = 6/327 (1%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L+A  + V  + G +   A   A         GV SHG+   P ++++L  G +  + + 
Sbjct: 19  LEATVSSVFTALGFEPVDAGQIAHSLVEADLRGVSSHGIMLVPMYVERLNAGGVTREREL 78

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +   GA    DA+  +G L++ + M  AIE A  +GIGLV++RNA+H+     +  QA
Sbjct: 79  DVLHDAGAAIVADARGGMGQLSSPQAMGLAIERAGRYGIGLVSVRNAHHFGAASRWAVQA 138

Query: 128 AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSYGMLEV 185
           A+ G +GI  +N+  +MP  G  E  +G NPL +A+P+      ++DM++S  + G + +
Sbjct: 139 ADAGCLGIAMSNTTPLMPAPGGAERVVGNNPLAIAVPTEAGAELVLDMALSAVALGKIRL 198

Query: 186 NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
              AGR +P +   D  G  T +         +LP    KG G+++++D++  +LS G  
Sbjct: 199 AAAAGRPIPDNWATDPSGLPTTDAEAAVLG-MLLPAAGHKGFGLALMIDVLTGVLSGGGW 257

Query: 246 ---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
              V  + ++       + +F+AI+ + L        +   + + V ++  A     + L
Sbjct: 258 GDRVRPLYREPDRPNDCAHLFLAIDPELLGGIEGFRQRSSALAERVRNSATAPGVDRLYL 317

Query: 303 PGHEFTTLLAENRRNGITVDDSVWAKI 329
           PG        + RR G+ V+ S    +
Sbjct: 318 PGEIEADRARQQRRTGVLVERSGLDGL 344


>UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000588C5F
          Length = 411

 Score =  339 bits (869), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 76/338 (22%), Positives = 150/338 (44%), Gaps = 13/338 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   +  +   R +++RG +   A   AE+       G +SHG+NR   +++ +E+G   
Sbjct: 24  VKVAEAHSFIERCMVARGTNPTHASLLAELLVSADSRGHFSHGLNRIDVYLENVEHGVTA 83

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  I  +      D +  +G +  +   D  IE A   GIG V  + +NH+   G 
Sbjct: 84  GDGEPVIIKEMAGTAWVDGRNLLGPVVGQFCTDLVIEKAKQAGIGWVVAKGSNHYGIAGW 143

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           Y  +  + G IG+ +TN+   + P  +K+   GTNP+  + P+       +DM+ +  +Y
Sbjct: 144 YSMRIKDTGMIGLSFTNTSPCVYPTRSKQIITGTNPIACSAPANNGDSFDLDMATTTVAY 203

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL------PMGYWKGSGMSIVLD 234
           G +E+  L G+ LP   G + +G  T +P  +     +         G +KG+G++++++
Sbjct: 204 GKVEICHLKGQTLPSGWGSNSDGKETSDPKEVLNGGGLQPLGGGETTGGYKGTGLALMVE 263

Query: 235 MIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +I  +L        + +      E  + Q F+A+  +    G     ++  ++    +AE
Sbjct: 264 VITGILGGAHFGTNIRKWSAGEREADLGQCFVALNPEAFAPG--FSERMTSLIAMCRNAE 321

Query: 293 RADENQAIRLPGHE-FTTLLAENRRNGITVDDSVWAKI 329
            A+    + + G      +    R  GI    ++  K+
Sbjct: 322 PANGETEVLVAGDRARHHMEKVAREGGIKYHRNLITKL 359


>UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TKN7_9PROT
          Length = 361

 Score =  337 bits (866), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 84/334 (25%), Positives = 151/334 (45%), Gaps = 5/334 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L+    RV  + G+    A   A+        G++SHGV R P ++++L    +
Sbjct: 12  RFPESVLRDTVARVFAACGMTDGDAVTLADSLVHADRRGIHSHGVLRVPDYVKKLTEDGV 71

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P   P+ ++  GA    D   ++G +     +D  I+ A    +   A+R +NH     
Sbjct: 72  DPRGHPRIVSDAGAALVIDGGNAMGQIAGTLAVDAVIDRARSVNVAFAAVRGSNHSGALD 131

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
            Y  + A +G IGI  +N++  M PWG  +  +G NP+ +A+P       ++D+++   +
Sbjct: 132 WYTMRIAAQGMIGIAGSNALPTMAPWGGVDKIVGLNPISIAVPGGEHGPIVLDVALGATA 191

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G + V     +Q+P    FD  G  T +      +  I P+G  KG G+++++ ++A++
Sbjct: 192 HGKIRVYAQKDQQIPEGWAFDASGVPTTDAAAAL-DGLIQPIGGHKGIGLALMVGLLASV 250

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS      E     D +      Q ++AI V    D     A + R+      + RAD  
Sbjct: 251 LSGAGYGTESGNMVDGATPGADGQFYLAINVAAFRDIADFTAHISRVARQYRDSRRADGV 310

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           + + LPG     +   NRR+GI ++D   A I  
Sbjct: 311 ERLYLPGDLEAEVAERNRRDGIPLNDEAVALIVE 344


>UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IPU0_DROME
          Length = 381

 Score =  337 bits (866), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 77/328 (23%), Positives = 143/328 (43%), Gaps = 14/328 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +        +  V    A+A A++       G +SHG+NR   +I  L      
Sbjct: 29  VAVAESRRFMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTD 88

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK +    A    D    +G +     MD AI+ A   G+G V  + +NH+   G 
Sbjct: 89  GAAVPKILKETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGW 148

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           Y  +A ++G +G+  TN+  +M P  AKE  +GTNPL +   +T     ++DM+ +  + 
Sbjct: 149 YAIRAMDQGLVGMSMTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAV 208

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLD 234
           G +E+ R  G  LP     D  G +T +  +      ++P+G       +KG G+  ++D
Sbjct: 209 GKIEIQRRKGAPLPDGWAQDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVD 268

Query: 235 MIATLLSDGASVAEVTQ----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +++ ++S      +V +           + Q+FIA++ +     P  + ++      +  
Sbjct: 269 ILSGVMSGANYSTQVRKWTHAGADSAADLGQVFIAVDPNCF--APNFEERMADFNSRLRG 326

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNG 318
           A   D ++ + L G +    +A+    G
Sbjct: 327 ATPTDPSKPVLLAGDKEKKGMADVDAAG 354


>UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VWV3_9CLOT
          Length = 410

 Score =  337 bits (865), Expect = 4e-91,   Method: Composition-based stats.
 Identities = 79/340 (23%), Positives = 153/340 (45%), Gaps = 9/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V  ++ +A  +++  + G + + AD  A+        G  SHG+NR P + Q+LE+G 
Sbjct: 55  IIVPEKESQAYVSKLFQTIGAEKKHADVVADHLTMAEMRGQASHGLNRIPFYTQKLEHGG 114

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
              +   K +     +   DA  ++G ++    M+  +E A+  G   VA+ ++NH    
Sbjct: 115 YKANPHMKILREDAGVALLDADDALGAVSCSHAMELCMEKASRTGCASVAVTHSNHIGFL 174

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             Y   AA++  IGI   NS +    WG +E  +GT+P  + +P+      ++D + S+ 
Sbjct: 175 AYYTMMAAKRNMIGIAVCNSGSSTAVWGTRERVLGTDPFSIGVPAKKHFPVILDCATSVV 234

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V     + +P +  ++  G  T           + P G +KGSG++IV+ +I  
Sbjct: 235 AQGKVSVAETENKPIPGNWAYNKNGEPTTVASEAMVG-TMRPFGDYKGSGIAIVISLICA 293

Query: 239 LLSDGASVAE-----VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
            L+      E        D S    ++   IAI++ K  D      ++   +D V S + 
Sbjct: 294 GLTGMPFDFEEENLRRISDLSAGSELAASLIAIDISKFTDAEAFKHRVDGFIDVVKSFKL 353

Query: 294 ADENQAIRLPGHEFT-TLLAENRRNGITVDDSVWAKIQAL 332
           A + + I +PG      + A     G  +  +++ K++ +
Sbjct: 354 APDTEQIYMPGEIEFNKVAANRAAGGFEIGPNLYQKLKNI 393


>UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfovibrio
           peptidovorans DSM 11002 RepID=C1TNX4_9BACT
          Length = 362

 Score =  336 bits (863), Expect = 6e-91,   Method: Composition-based stats.
 Identities = 84/348 (24%), Positives = 151/348 (43%), Gaps = 17/348 (4%)

Query: 1   MKVTFEQLKAAFNRVLIS-RGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG 59
           M V+++ L      +L    G     A   AE+        V SHGV R   + + LE G
Sbjct: 1   MIVSYDGLTRHVMDILEKGLGYTESQARITAEVLVEADARAVPSHGVARLAFYRKNLEGG 60

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
               D +P+ +         D +  IG   A   MDR ++ A + G     +R++NH+  
Sbjct: 61  FAFTDREPQVVRETPVSLVVDGKSGIGPSVAAFSMDRCVDKALEIGTCSCVVRDSNHYGM 120

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSM 177
            G +  +AA++G + +  TN+         KE  +GTNP+ VAIP     + ++DM+  +
Sbjct: 121 AGLWAERAAKRGCMAVAMTNTRKCCIVTFGKERLLGTNPIAVAIPGSGEEMFLLDMATPV 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMGY------------- 223
            ++G +EV     + +P+    D+ G++T +   IE   +    +G              
Sbjct: 181 VAHGKVEVYDRRKKPMPLGWVVDETGSVTDDASHIEDLFKSESSLGGHLFLGGEGEELGG 240

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KG G+ ++++++ + LS G    E  Q+     GI+  F A  +D   D       +  
Sbjct: 241 HKGYGLGLMVELLCSALSLGRWSPETFQEPGSGSGITHYFAATRLDVFGDESAIKDSVSS 300

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           I++ V  +E+AD +  I + G +         R GI +D +    ++ 
Sbjct: 301 ILESVRRSEKADGHDRIFIHGEKEREARERAVREGIELDRATEDMLRR 348


>UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GVF2_9DELT
          Length = 365

 Score =  335 bits (861), Expect = 9e-91,   Method: Composition-based stats.
 Identities = 85/335 (25%), Positives = 149/335 (44%), Gaps = 10/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KVT   ++    ++LI  GV  E  +   +      +SG  +HG+ R P ++++++ G +
Sbjct: 24  KVTISAVRNISKQILIHVGVSPEHTEIIVDSIVYAHQSGKGTHGLGRLPLYVKKIQAGFM 83

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             +     +     +   DA+   G + A K MD  I  A  +GIGLV +R +N++    
Sbjct: 84  AAETSTDLVKDTPVLAVMDAKNGFGQVAATKAMDLCINKANYYGIGLVGVRRSNNFGTAS 143

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
               QAA KG IGI   NS   + P G      GTNPL +A P         +DM+ S+ 
Sbjct: 144 FITEQAAAKGMIGIVLGNSGPAIAPTGGSHPLFGTNPLGIAFPNPVGEFPISLDMATSVV 203

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +     +  ++P     D  G  T +P    +   ++P+G  KG G+S+ +D++A 
Sbjct: 204 ARGKVRQAAKSNEKIPFGWALDGNGQPTCDPFQALEG-SMIPIGDHKGYGLSLAIDILAG 262

Query: 239 LLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           LL+  A   +V    D S       + + I VD  +       K+  ++  + S     +
Sbjct: 263 LLTGSAFGGDVHPLGDMSANSNYGHLCMTINVDFFMTIDEWSQKIAYLVSSIKSC---GD 319

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + IR+ G      +  N +  + V + V   I++
Sbjct: 320 PEKIRIHGESSHRSI-RNSKEYVLVKNRVINDIES 353


>UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclobacillus
           acidocaldarius RepID=C8WTM6_ALIAD
          Length = 353

 Score =  335 bits (860), Expect = 1e-90,   Method: Composition-based stats.
 Identities = 88/335 (26%), Positives = 149/335 (44%), Gaps = 6/335 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L+A       + GV    AD  A     +   G+ SHGV R P ++  L++G + 
Sbjct: 5   VAPASLQAFARACFAAAGVAKRDADWSATALVESDLRGISSHGVMRLPWYLHGLKSGKVN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+ +     +       DA  ++G ++AK+    A+ELA + G+G VA+R ANH      
Sbjct: 65  PNPRLVWRRTGPVTAVLDADDALGFVSAKEAAAHAVELAREAGLGAVAVRRANHCGALFL 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y   A   G +G C  N+   + P G ++  IGTNP+  A P+       +D+S S  S 
Sbjct: 125 YAEWATLYGMVGFCCANTHPALAPPGGRKPVIGTNPIAFAAPTPLDYPLSIDLSTSAISR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +      G  LP     D++G  TKEP     +  +LP+G  KG  ++++++++A +L
Sbjct: 185 GAVIERARRGESLPDGVAVDEDGAPTKEPHRAL-SGALLPIGGAKGYALALMVEVLAGVL 243

Query: 241 SDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      +   +  D+    G    ++A+  D  +       ++  ++  +  A  A   
Sbjct: 244 AGAQVAGDVGFMFADDGKPPGNGFFYLALHPDFFVGQEAFLQRMASLVAEIHDAPSAQGQ 303

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I +PG           R GI + D VWA +  L
Sbjct: 304 PPISVPGERRHRERVSRSRRGIPISDEVWADLAEL 338


>UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CWH3_9CLOT
          Length = 337

 Score =  334 bits (858), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 139/333 (41%), Positives = 211/333 (63%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ FE++KA   +VL  RG   + A+  A   AR +  GVY+HG+NRF R I+ ++ G 
Sbjct: 4   VRLPFEEVKACLCQVLAGRGCPEKKAEKVAHEMARNSLEGVYTHGINRFARLIRNIDEGI 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P+    +GA+EQ D    +G   A   M+ A++LA  +GIGLVALRN NHWMR 
Sbjct: 64  VRPGAEPEVTVRMGAMEQVDGHLGLGITNAWFSMEEAVKLAKSYGIGLVALRNTNHWMRA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
            +YG+QA + G   +C+TN++  MP WGA + RIG NPL+ A P     ++ DM+MS FS
Sbjct: 124 ATYGYQACDAGMAAVCFTNTMPNMPTWGAVDSRIGNNPLVFAFPRREGHLITDMAMSQFS 183

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE+ RL GRQ+ +D GFD  GNLT++P  + K++RILP GYWKG+ +S +LD+ A +
Sbjct: 184 YGALELARLQGRQMAIDAGFDTAGNLTRDPDSVIKSQRILPTGYWKGAALSFMLDIFAGV 243

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LSDG +V+ V + + DE+G+SQ+FIA++   L+     +  ++  +  + ++ +A     
Sbjct: 244 LSDGNTVSGVGRLSGDEHGVSQVFIAVDYRNLVTQEAAERIVEGAVKDLLASGKAQGTDR 303

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I   G       A+N +NGI VD+ VW +I +L
Sbjct: 304 IIYTGQLTLECRADNLKNGIPVDEGVWNEISSL 336


>UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TYW6_9PROT
          Length = 352

 Score =  333 bits (855), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 90/338 (26%), Positives = 157/338 (46%), Gaps = 9/338 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +  E+L     R++   G D   A+  A    +    G  SHGV   PR+++    G 
Sbjct: 1   MIIGHERLTGIVTRMIQGAGSDLAEAETVATNLVQANLMGHDSHGVGLAPRYMKHARAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +P  IT  G     D     G    ++  + AI  A + G  +V LR  +H  R 
Sbjct: 61  MNLGVRPSVITDNGVYLLLDGNMGYGQTVCREATEMAIARAKEKGAAIVGLRRTHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMS 174
           G++G   AE G I I + N+      + P+G  E R  TNP   AIP+   TP+ ++DM+
Sbjct: 121 GAWGEMCAEAGLISIHYVNTTGHRPYVAPYGGFEARYSTNPYCTAIPATDKTPMIVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIV 232
            S  + G + V   AG++ P D     +G  T +P VI +     +L  G  KG G++++
Sbjct: 181 TSRVAQGKVRVAYYAGKKTPADALVGPDGLPTDDPKVIFEEPYGAMLSFGQHKGYGLAMI 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A  L+ G +  E   D +     + + I I+           +++ +++++V+S++
Sbjct: 241 CEILAAGLTGGGTAREELMDQNTICN-NMLMIVIDPKGFGADIPFRSEIDQLVEHVSSSK 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
            A     +R PG      +AE    GI +DD+ W +++
Sbjct: 300 TAVGFDKVRFPGDPEREAMAERAAKGIWIDDNTWGEMR 337


>UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9XTB4_CAEEL
          Length = 400

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 78/341 (22%), Positives = 143/341 (41%), Gaps = 13/341 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  +++K      +   G     A   A +       G YSHG+NR   +++ +E     
Sbjct: 49  VAKDEMKRFMVECMTKVGATESHATQLALVLLEGDIRGHYSHGLNRLDMYVRDIEQNVCK 108

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +         D    +G +     MD AIE A + GIG V  + +NH+   G 
Sbjct: 109 GDGEPIILKEKAGTAWVDGNNLLGPVVGNFCMDLAIEKAKNAGIGWVVAKGSNHYGIAGW 168

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           Y  +A +KG +G+  TN+  +  P  +    +GTNP+ +A P T     ++DM+ +  + 
Sbjct: 169 YALRAMKKGMLGMSMTNTSPISFPTRSAVPALGTNPISLAAPGTGDDSFVLDMASTTVAI 228

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLD 234
           G +E+       +P+  G  + G  T +P  +     +LP+      G +KG G+S +++
Sbjct: 229 GKVELAARKENPVPLSWGVGEGGKETTDPTKVLYGGGLLPLGGVEVSGGYKGYGLSSMIE 288

Query: 235 MIATLLSDGASVAEVTQDNS--DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   +L+       V +  S   E  + Q F+AI+ +    G     +LQ  M  + +  
Sbjct: 289 IFCGILAGAHWGPHVRKWMSTKSEADLGQCFVAIDPEAFAPG--FADRLQDFMQTMRALP 346

Query: 293 RADENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
            +  +  + + G       A   +  GI    +    +  L
Sbjct: 347 TSSPSFKVEVAGDMERRHEALVEQLGGIPYHKNQITFVNDL 387


>UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimonas manganoxydans
           SI85-9A1 RepID=Q1YIU0_MOBAS
          Length = 381

 Score =  330 bits (848), Expect = 3e-89,   Method: Composition-based stats.
 Identities = 75/335 (22%), Positives = 155/335 (46%), Gaps = 5/335 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +V     +     +L + G+    A   A++       G+ SHG+   P + QQL NG  
Sbjct: 31  RVASATWRRQALAILSAWGMSDAHAAVTADVLVAADLMGIDSHGLTLLPLYDQQLGNGGA 90

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                 + +  +GA+   D     G +     +D A E A   GI  +++RN+NH+   G
Sbjct: 91  TATPNIEVVHDMGAVALIDGDAGFGQVPGMMAVDMAAERAGRFGISAISIRNSNHYGAAG 150

Query: 122 SYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
            Y  + AE+G +GI  ++   A + P G    ++GTNP+  A PS      ++DM+ S  
Sbjct: 151 VYVRRLAEQGLVGISTSSVWRAGIVPTGGLAPKLGTNPIAFAAPSARGQPFLLDMATSTA 210

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L++ + A  +LP       +G   ++P +   +  + P+G  KG G++ +++++++
Sbjct: 211 AIGKLKLAQRAETELPEGWALTRQGTPQRDPNLALLDPLLAPLGGHKGYGLATMVEVLSS 270

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSAERADEN 297
           +LS  A +  +      ++ +    +A++   +       +A L R++D + + +  D  
Sbjct: 271 VLSGAA-LTPLRGKPGQKHDVGHFILALDPAMIRGSRAAFEADLDRMVDGLRATDPIDPA 329

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + + G       A+   +GI +   + A+++ +
Sbjct: 330 HPVMVAGDPEYAREADRLAHGIPLSSKLAAQLREI 364


>UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SP37_METPP
          Length = 365

 Score =  330 bits (847), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 87/338 (25%), Positives = 151/338 (44%), Gaps = 10/338 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   +L+     +  + GV  E AD  AE+       GV SHGV   PR+++ +  G + 
Sbjct: 11  VDSGELRMKVAGLFQAVGVSPEHADQIAEVVVFADLRGVESHGVQFTPRYVRGIARGHLN 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P    + +   GA+   DA   +G L+A++ M  A+ +AA+HG G VA+RN+NH+     
Sbjct: 71  PKPDIRVVHRRGAVAVVDADNGLGFLSARRAMKEAMAIAAEHGSGSVAVRNSNHFGPAAF 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y   A E G IG   T+       WG++   +  +P+  A P+      +VD + +    
Sbjct: 131 YPMMALEAGMIGYATTDGPPHTVVWGSRRPVLSNDPVGWAFPTLEGLPIVVDTAFTGV-K 189

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             + +    G  +P D     +GN T +P V  +   +LP+G  KGS + I  +++   L
Sbjct: 190 EKIRLAAQRGGTIPADWAVGPDGNPTTDPKVALEG-YLLPIGQHKGSALIIANEVVCGAL 248

Query: 241 SDGASVAEVT------QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           +      EV+       D+ D +       A++     D      +   +   + +A RA
Sbjct: 249 AGALFSFEVSPKLVMGADHHDSWKCGHFVQALDPGAFGDRDAFLRRTSELASALRNAPRA 308

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  Q I +PG     L A+  R+G+ +  +    + A+
Sbjct: 309 EGVQRIYMPGEIEAELSAQRLRDGLPLAVTTLEALDAV 346


>UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SD16_9ACTO
          Length = 732

 Score =  330 bits (846), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 87/345 (25%), Positives = 153/345 (44%), Gaps = 13/345 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V  + L+     VL + GV    A   A + A    SG+ SHG+ R P ++  + NG 
Sbjct: 374 VRVPADVLETWTAEVLEAVGVRPSHARDTARVLAYADLSGIDSHGIARLPAYVGAIGNGV 433

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D +P   +   A+   D    +G+       D A+  A  +G+G V +R ++H    
Sbjct: 434 IAVDGRPSVHSDGSAVALVDGHDLLGHPVTTFAFDEAVARARRYGVGWVNVRRSSHHGAS 493

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVA--IPSTPITMVDMSMSMF 178
           G Y + AA  G +G+  TN+  V+ P GA    +GTNPL +   +P     + DM+ S  
Sbjct: 494 GCYVYDAARLGLVGLAATNTGPVVAPAGAARPYLGTNPLALGVPVPGEEPLVFDMATSAV 553

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMG------YWKGSGMSI 231
           + G  E+    G+ +P+  G D EG  T +P  +      +LP+G        KG G+ +
Sbjct: 554 AAGKFEIALRLGKPVPLGWGVDAEGRPTTDPAAVFPGRGALLPLGSDRERSSHKGYGLGL 613

Query: 232 VLDMIATLLSDGASVAEV----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           +++++  +L+ G +   V     +  +     S + + ++  +L D         R++  
Sbjct: 614 LVELLTAVLAGGPTGPGVGNLTFRSGARSPDTSHLVVVLDPARLGDPEAIGGGAARLLAE 673

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +      D +  +R PG       A  R  G+ +D      +QAL
Sbjct: 674 LRGLAPVDPDLPVRTPGQRAAAERALRRELGVPLDAETHRALQAL 718


>UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C6XSR8_PEDHD
          Length = 327

 Score =  329 bits (844), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 144/331 (43%), Positives = 207/331 (62%), Gaps = 7/331 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ F++LKA F RVL+      ETAD+CA +FA  +  GVYSHG+NRFP F++ ++ G 
Sbjct: 1   MRIPFQELKAEFKRVLLKLSFPPETADSCALVFAANSRDGVYSHGLNRFPVFVKLVQKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P  +   GAIE+WD   + G   A   M RA+ELA  +GIG VA++N NHWMRG
Sbjct: 61  IKANALPALLERNGAIERWDGNFAPGMSNASHCMARAVELAKINGIGCVAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G+YGWQAA+ G IGIC+TN+ A MP WG K+  +G NPL++AIP      ++DM+MS FS
Sbjct: 121 GTYGWQAADAGCIGICFTNATANMPAWGGKDPVLGNNPLVIAIPRKEGHVVLDMAMSQFS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG ++   L    LP  GG+D++GNL+ +P VI K +  LP+G+WKGSG+S+VLD++A  
Sbjct: 181 YGKMQEYELKNEALPFPGGYDEQGNLSTDPAVIRKTKLALPIGFWKGSGLSLVLDLLAVA 240

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LS G S  +++   +DE G+SQ FIAI           DA +  ++ Y  ++E       
Sbjct: 241 LSGGNSTGKISAQ-ADETGVSQCFIAI-----RQPDMHDALIAEVLAYTKNSEAVKAGGQ 294

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  PG        EN   GI V++ +W +++
Sbjct: 295 VSYPGERTLQTRLENEEKGIPVNEEIWMQVK 325


>UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=C6DD67_PECCP
          Length = 362

 Score =  328 bits (842), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 90/336 (26%), Positives = 158/336 (47%), Gaps = 10/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            T   L+      L    VD+  A   A+    ++  G  SHGV+  PR+I  +  G + 
Sbjct: 26  FTHHYLRDYLRDRLTENDVDASIAGTVADNLVESSLKGHDSHGVSMLPRYIDAIREGGLS 85

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P AQ ++    G +  +D Q+  G + AK+ +   I  A  HG+ +V+L NA+H  R G+
Sbjct: 86  PHAQAEKTLDFGPLISFDGQQGFGQVVAKQALTEGIARAQTHGLVVVSLANAHHLGRIGA 145

Query: 123 YGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           +  QAAE G + + + N  +  V+ PW  ++ R GTNP    IP       ++D + S+ 
Sbjct: 146 WAEQAAEAGLVSLHFANVYTKPVVLPWQGQQARFGTNPFCAGIPVEHDDPVILDFATSVI 205

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIVLDMI 236
           +     +    G+ +      D+EGN T +P  + +     +LP G  KGSG+S+V  ++
Sbjct: 206 AGNKARIAWNEGKSVAPGCIVDNEGNPTVDPRWLMEQPLGALLPFGEHKGSGLSLVCSLL 265

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
              L+ G +     +    +   S + I I+  KL    T   ++  ++++V  +    +
Sbjct: 266 GAALTGGKT-ERTAKGEGKQIINSMLSILIDPQKLGGAATYQQEIPALLEWVRQSR---D 321

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + LPG +      + + NGI VDD  W ++  L
Sbjct: 322 DNELLLPGDKEKQTYRQRQENGIFVDDVSWGQLSYL 357


>UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH
          Length = 351

 Score =  328 bits (842), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 82/336 (24%), Positives = 147/336 (43%), Gaps = 7/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E L+    R L +RGV ++ A+  A +       G  +HGV R  +++ +LE G   
Sbjct: 6   ISAEALQDFVARALSARGVPTQDANKVAGLMVEADIYGYGTHGVFRLRQYLARLEGGGCN 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P      +    A    D     G+L      D A+E A   GIG V +R  NH      
Sbjct: 66  PAPNISVLQQTVATALIDGDNGFGHLAMAAARDLAMEKARQAGIGWVGVRRGNHAGPLAL 125

Query: 123 YGWQAAEKGYIGI-CWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFS 179
           Y    AE G +G+     S   +PP+G  +  +GTNP+  + P+      + DM+ ++ +
Sbjct: 126 YVRPQAEAGLLGMAAAVGSANHVPPYGGTDLLLGTNPIAFSAPAEGPDPFVFDMATTVAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G ++     G  +P       +G    +P   +    +LP+G  KG G+S+ + ++A +
Sbjct: 186 MGKIKTLLQQGADMPEGWMVGRDGKPLTDPAR-KSEGFLLPIGGPKGFGLSVAIGLMAGV 244

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+  A  ++V   T D +      Q  +A++      G       +R+   + ++     
Sbjct: 245 LNGAAFGSDVVDFTSDTTSPTNTGQFVMALDPAAFGLGDGFAETARRVFGEMRASPPLPG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  +RLPG   T      RR G+T++ ++   + AL
Sbjct: 305 HHPVRLPGDGKTQAAETRRRQGLTLNPALRKDLDAL 340


>UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CRX3_9FIRM
          Length = 356

 Score =  328 bits (842), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 78/335 (23%), Positives = 138/335 (41%), Gaps = 8/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   +LK    ++ ++ G+    A A +E+        V SHGV R   ++++++ G   
Sbjct: 6   VDSGKLKEYTTKLFLAAGLAQTDAQAVSELLVHADLRNVRSHGVLRTVPYLEKIQKGGAS 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             +    +         DAQ  +G L  +K +  A E A    + +V +RN+NH+  G  
Sbjct: 66  KTSAYPVVKETTNSAVIDAQGGLGALAGEKAVAIAREKAKTALMSMVVVRNSNHFGMGAH 125

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFS 179
           +  + A    IG   + +   M P G KE  +G NP  VA  +    P   VDM+ S  +
Sbjct: 126 WALKLAGNDMIGFACSTTDLTMGPPGCKEPFMGNNPFAVAFKAGEKYPEFCVDMATSGVA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G  +     G+ +P     D  GN T     +E    + PM   KG G+++++++ ATL
Sbjct: 186 LGKCKDLAKRGKPIPSGWMLDKNGNDTT---KVEDCYMMTPMAGHKGFGIALIVELFATL 242

Query: 240 LSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS G    ++            SQ F  I +    D        +  +D +      +  
Sbjct: 243 LSGGVLSPDINNQDLPDVPELSSQCFGCINISAFRDLAEFQETAENYIDRLHQIPMKEGA 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + PG    T    N + G+ + +++   + A+
Sbjct: 303 GDAKYPGEIEYTSKLINLKEGVVLPETLTEDLMAI 337


>UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11JG3_MESSB
          Length = 375

 Score =  328 bits (842), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 72/343 (20%), Positives = 149/343 (43%), Gaps = 11/343 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M   + Q +     +L++ G+    A   A++       GV SHG++    +  +   G 
Sbjct: 1   MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A  K +         D    +G++      D AIE A   GI + ++RN++H+   
Sbjct: 61  LKMNADFKVVRETPVSVLIDGDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAV 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
           G +   AA  G I +  T++  + + P    E ++GT+PL  A PST     ++DM+ + 
Sbjct: 121 GYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLSFAAPSTDENPFLLDMATTT 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMGY------WKGSGMS 230
            +YG +         +P+  G D  G  T +P  V  +   + P+G       +KG G+S
Sbjct: 181 VAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS 240

Query: 231 IVLDMIATLLSDGASVAE-VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVT 289
           ++++++++ LS    + + +       + I   ++A++     D    +  +      + 
Sbjct: 241 VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALR 300

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +  +E   + + G     +  E  R G+ +   + AK+ A+
Sbjct: 301 NTKPVEEGTPVMVAGDPQWKMAEERLREGVPIGKGLRAKLIAV 343


>UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=D0KCK6_PECWW
          Length = 355

 Score =  328 bits (841), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 91/340 (26%), Positives = 147/340 (43%), Gaps = 10/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++  +L A    VL   G +   A    E        G  SHG    P +++ +  G 
Sbjct: 1   MQISANRLMATVQVVLQKAGCEENEARIVTEHLVAANLKGHDSHGAGMLPHYVEFIGKGI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+   R  G  T K+ M  AIE     G+ L+ L +  H  R 
Sbjct: 61  MHPNTPARLLRDSGAVLQFTGDRGFGQRTGKEAMQAAIERVKTTGVCLMTLSSTCHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPSTPI---TMVDMS 174
           G+YG  AA+ G + I + N      ++ PW   E R GTNP+ +A P T      ++D +
Sbjct: 121 GTYGEMAADAGLVSIHFVNVNDLEPIVAPWCGSEARFGTNPICIAFPPTEHNAAFVLDFA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN---RRILPMGYWKGSGMSI 231
            S+ + G   V  LAG+    +   D  G  T +P V+ +      + P+   KG G+ +
Sbjct: 181 TSVVALGKTRVAYLAGKTFDEEVMLDCNGVSTNDPKVMWEGEKHGALKPIAKHKGGGLIL 240

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             +M+A LLS G ++             +   I I+   ++       +   ++DYV S+
Sbjct: 241 AAEMLAGLLSGGGTIQPENVRQGAIVN-NMTTIVIDPTSMVSMAWLQKEYDAMLDYVRSS 299

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              D  Q I + G       A+ R +GI V D  W KI  
Sbjct: 300 TAPDPTQPILIAGEPERLSQAQRRADGIYVSDQEWQKIVE 339


>UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Burkholderia
           glumae BGR1 RepID=C5A802_BURGB
          Length = 357

 Score =  327 bits (840), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 83/335 (24%), Positives = 152/335 (45%), Gaps = 10/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E+L+       + RG+ +  A   A    RT+  G+ +HGV   P ++++L+ G   
Sbjct: 5   IQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+   + +         DA  + G +        A ELA + G+G+VA+ N+NH+     
Sbjct: 65  PEPALRTVRRFQGTALVDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASV 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           YG   A +G IGI  T++ A M P+ A     GTNP+  A P+    + ++DM+ S  SY
Sbjct: 125 YGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNPICFAAPARDGDLYLLDMATSQISY 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             ++  R  G  LP       +G    +P  +     +  +G +KG G+++++ +++ LL
Sbjct: 185 SQVKHFRRNGMALPSGWALGADGQPVTDPAQVV---SLATLGGYKGQGLAMMVQILSCLL 241

Query: 241 SDGASVAEVTQDNSDEYG----ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +       +T  +++ Y     I    IAI+  +        A +  +M  +     A+ 
Sbjct: 242 TAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAEG 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + +++ G      +A     GI +DD  W  +QA
Sbjct: 302 -ERVQVAGDPQKAAIARRTAQGIPLDDDEWRGLQA 335


>UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C5EL83_9FIRM
          Length = 349

 Score =  327 bits (839), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 129/334 (38%), Positives = 200/334 (59%), Gaps = 2/334 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ ++ +K    +  ++ G+  E A+ CA +  +++  GV SHG+NR PRF++ ++ G 
Sbjct: 3   LRIPYDTIKETVKKAFLNVGLSEEQAEVCATIHTQSSADGVESHGLNRIPRFVEYVQKGW 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  + +P+   + GA+E +D    IG   A    DRA+ELA +HGIG V L+N  HWMRG
Sbjct: 63  INLEGKPELAGARGAVENYDGHLGIGITNALFCADRAMELAKEHGIGCVTLKNTTHWMRG 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G+Y W+ AE G++GI W N+ + MP WG+ E  +G NP  +AIP      ++DM+MS ++
Sbjct: 123 GTYAWRMAEAGFMGISWINTESCMPLWGSDEPGVGNNPFCIAIPREDGPIVLDMAMSQYA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG L V RLAG++LP  GGFD +GNLT +PG IE+++RILP GYWKGSGM+I LD+ A L
Sbjct: 183 YGKLGVYRLAGKELPFPGGFDKDGNLTSDPGAIEESKRILPTGYWKGSGMAIALDLAAAL 242

Query: 240 LSDGASVAEVTQDNSDEY-GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++G    ++ + N     G  Q+FIA +           + L R +    ++    E  
Sbjct: 243 LANGNCGTDMDEANQGSCTGCCQVFIAFDPYLFGSKDEIQSMLNRRVAAADASHPEREGS 302

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  PG    +  A +   G+ VD+ VW ++QA+
Sbjct: 303 HVTCPGERTVSTRARSMAEGVNVDELVWEQVQAI 336


>UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C1C568_DROME
          Length = 399

 Score =  326 bits (837), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 70/307 (22%), Positives = 129/307 (42%), Gaps = 3/307 (0%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++ +      L+  GV        +E        G Y  G+NR   ++  L++G   
Sbjct: 48  VLVDEARRFIQDCLLRVGVSPSKVRCISEFLVVADYRGNYGSGLNRLDYYLSDLQSGHAK 107

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+P  I+   +    +   ++G       MD A++ A D GIG V  + ++       
Sbjct: 108 VGAEPSIISETVSTAHVNGNSALGVFVGNFCMDLAVKKAEDSGIGFVVAQQSHDIGMASW 167

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSYG 181
           + ++AA KG  GI  +NS   M    +K   IG+N     +       ++DM+ S+   G
Sbjct: 168 FTFRAAGKGLAGIVMSNSAPTMMGPNSKSASIGSNCFAFCVKGEEYHFVLDMATSVKDIG 227

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +E        +P     ++ G  T  P +  +   + P G  KG  +S V+D++  +LS
Sbjct: 228 AVEWAWANDEYIPHGWAANEGGLSTCFPSLALRTPLLFPAGGHKGYCLSAVIDILCGVLS 287

Query: 242 DGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                  +T D +    + Q+FIA++ +     P    +       + +++ AD+++ IR
Sbjct: 288 GAQYATHITMDQNQPSNLGQVFIALDPEFF--LPNFMERFDDFCGRIQNSQPADDSEPIR 345

Query: 302 LPGHEFT 308
           LPG    
Sbjct: 346 LPGELER 352


>UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=Q125D0_POLSJ
          Length = 364

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 85/339 (25%), Positives = 150/339 (44%), Gaps = 10/339 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++  QL+A    VL + G  +E A   A        SG  SHGV   PR++  +  G + 
Sbjct: 15  ISAAQLRAQVATVLKAAGSSAEEATTVAANLVLANLSGHDSHGVGMLPRYVDAVLEGGLK 74

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P++  + +   G++   D QR  G +  ++ M   I+ A  HG  ++ L NA+H  R G 
Sbjct: 75  PNSSVRVVLDTGSLLTLDGQRGYGQIVGEQAMALGIDRAKAHGSCIMTLGNAHHLGRIGH 134

Query: 123 YGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           +   A ++G + + + N  S  V+ P+G  + R GTNP  + +P       ++D + S  
Sbjct: 135 FAEMAVDQGLVSLHFVNVLSRPVVAPFGGGDGRFGTNPCCIGVPLKGREPFVLDFATSRV 194

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN------RRILPMGYWKGSGMSIV 232
           + G + V    G Q+      D+ G  T +PGV+           +L  G  KG GM++ 
Sbjct: 195 AQGKMRVAHNKGIQVEPGTLIDEHGRPTTDPGVVVVPQSNGLFGALLAFGEHKGYGMAVA 254

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++   L+ G +  + T           + I I+  KL      + +    +D++ +  
Sbjct: 255 CELLGGALTGGGTWHKATDPAVRAVVNGMLTILIDPAKLGTQAAFEQEAVAFVDWLQAGP 314

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A    A+++ G       A+    GI VDD  W ++ A
Sbjct: 315 VAPGFDAVQIAGDPERATRAQREVEGIAVDDQTWQEMVA 353


>UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomycetaceae
           RepID=D2R8T1_9PLAN
          Length = 351

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 84/336 (25%), Positives = 149/336 (44%), Gaps = 12/336 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  + L      +L++ G   E A   +         G  SHGV R P ++  +++G+++
Sbjct: 4   IAADSLTKFAEAMLLAGGATPEEARITSVSLVDANLRGYESHGVMRIPYYLDAIQSGEVV 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+ K +    A    D Q   G + A ++ +    LA   G+ +  +  + H  R G 
Sbjct: 64  PAAELKILDQGAARVVADGQWGFGQVQAVRLFELLAPLAQQEGLAVGTMIQSGHIGRLGE 123

Query: 123 YGWQAAEKGYIGICWTNSIAV---MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           Y   AA +G + I   NS      + P G K  R+ TNPL + +P      ++D S S  
Sbjct: 124 YNEMAAARGLVSILMVNSHGAAVRVAPPGGKAPRLSTNPLAIGVPCGDAPLVLDFSTSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGY---WKGSGMSIVL 233
           + G + V ++AG+ +P     D+EGN T +P  +  N    ILPMG    +KG G+ +++
Sbjct: 184 AEGKVRVKKIAGQAVPEGWLLDNEGNPTTDPNTLYGNPPGSILPMGGTQSYKGFGLGLMI 243

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           +++   LS G +   V        G     + ++  +        A++ +++DY+ +  R
Sbjct: 244 EILTGALSGGVTARPVPYPKK---GNCVFMMLVDPARFGGSDHFAAEVTQLVDYIRTTPR 300

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +    I LPG     L A  +  G+  D   W  +
Sbjct: 301 VEGCNEITLPGDPERKLYAARKSTGLVFDPENWKAL 336


>UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5TC94_ACIDE
          Length = 376

 Score =  323 bits (829), Expect = 5e-87,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 142/336 (42%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            + F +L+A   ++ +  G   E A   A   A     G  SHG+ R P ++  L +G +
Sbjct: 39  HIAFAELQALLTQIFLRHGTSPEVAAILAANCASAQRDGADSHGIFRIPGYLSTLASGWV 98

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+           DA         +      I+ A  +GI L+A+RN++H+    
Sbjct: 99  NGRAVPQVEDVAPGYVAVDAGNGFAQPALEAARGLLIDKARRNGIALLAIRNSHHFAALW 158

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 A +G + + + NS+A + P G  +   GTNP+  A P       + D++ S  +
Sbjct: 159 PDVEPFAREGLVALAFVNSMACVVPTGGHKALFGTNPIAFAAPRAGGDPLVFDLATSAIA 218

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G +++    G +LP   G D  G  T +P  I     +LP G +KGS +S++++++A  
Sbjct: 219 HGDVQIAAREGHRLPEGYGVDRLGQPTCDPAAILDGGALLPFGGYKGSALSMMVELLAAA 278

Query: 240 LSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+ G    E        +      ++ I I+  K   G     + + ++ ++        
Sbjct: 279 LTGGNFSFEFDWSQHPGAKTPWTGELLIVIDPSK-GAGNQFARRTETLVQHMR------G 331

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               R PG       A++ R+GI +     A++  L
Sbjct: 332 AGQNRQPGDRRYQQRAQSDRDGIAITGEELARLHEL 367


>UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 Tax=Proteobacteria
           RepID=A1WAI4_ACISJ
          Length = 350

 Score =  321 bits (824), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 82/340 (24%), Positives = 144/340 (42%), Gaps = 16/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            V F+ L+    R+    G  +E A   A   A     G +SHGV R P ++  L +G +
Sbjct: 13  HVPFDDLRGTLARIFERHGTSAEVAAVLAHNCASAERDGAHSHGVFRIPGYLSTLASGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+           DA         +      +  A  +G+ L+A+RN++H+    
Sbjct: 73  DGRAVPRVEDVAPGYLAVDAGNGFAQPAYRAAYSALVAKARANGVALLAIRNSHHFAALW 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 A+ G + +   NS+A + P G      GTNP+  A P       + D++ S  +
Sbjct: 133 PDVEPLADDGLVALALVNSMACVVPSGGTTALFGTNPIAFAAPRAGHEPLVFDLATSAIA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY----WKGSGMSIVLDM 235
           +G +++    GR LP   G D  G  T +P  I     +LP G     +KGS +S+++++
Sbjct: 193 HGDVQIAAREGRLLPDGHGVDRHGQPTNDPRAILDGGALLPFGGVHSSYKGSALSMMVEL 252

Query: 236 IATLLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +A  L+ G    E        +      ++ IAI+  K   G +   + + ++  + +A 
Sbjct: 253 LAAALTGGNFSFEFDWSGHPGAQTPWTGELIIAIDPAK-SAGRSFAQRCEDLVQAMAAA- 310

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                   R PG       A + ++GI +  + WA++Q L
Sbjct: 311 -----GQTRQPGERRYRQRARSLKDGIPLPATTWAELQRL 345


>UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobacteria
           RepID=B1K2F1_BURCC
          Length = 349

 Score =  321 bits (824), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 81/334 (24%), Positives = 143/334 (42%), Gaps = 6/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V+   L       L + G+    A   A +       G+ +HG +R   +  +L  G I 
Sbjct: 11  VSKAHLTELTIEALCALGLTRTDATDTATILVLADLFGLRTHGTSRIESYGSRLRIGGIN 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P           A+ + D    IG L   + +D A+  A + GI  V +R +NH+     
Sbjct: 71  PAPSITTEQVAPALYRLDGDNGIGPLVGHRALDLAMTAAREQGIACVFVRGSNHFGPVSP 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y + AA +G+  I  +N+   + PWG  + R+G +P+   +P+      M+DM++S+ + 
Sbjct: 131 YSYLAAMQGFASIIGSNATTTIAPWGGTDARLGNSPVGFGVPNPNGRPFMLDMAISVAAR 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +      G  +P D   D +G  T +P     +  +LP+G  KG G+++V+D+ A LL
Sbjct: 191 AKIRNALKRGEPIPGDWATDAQGKPTTDPKAAL-DGFLLPIGGHKGYGLALVVDLFAGLL 249

Query: 241 SDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           S  A +  V     D      +   FI I+  +L       A++      +  ++ AD  
Sbjct: 250 SGAAYLTHVKSWEDDPEQPQNLGHFFILIDTTRLGSTGWLAARMADYAAILHGSQPADPE 309

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +PG      L      GI +  +  A ++A
Sbjct: 310 APVIVPGEIELGRLERQMAEGIDIGAAQLAMLEA 343


>UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitobacter
           RepID=A3SYU7_9RHOB
          Length = 356

 Score =  321 bits (823), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 88/339 (25%), Positives = 151/339 (44%), Gaps = 9/339 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L      +L   G D+  A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MAVDAGRLTDFATAILAHAGQDAGRAAKVAARLVGANLAGHDSHGVGMIPAYVDGILAGQ 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A  + +   G     D  R  G++ A++ M  AI+ A  H    ++LRN+ H  R 
Sbjct: 61  LDAAADIELVQDKGPFLLVDGHRGFGHIVAEQAMTLAIDRAQAHHFATLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMS 174
           G +G  AAE G+I I + N   +  ++ P+G  + R  TNP   AIP+T   P+ ++DM+
Sbjct: 121 GDWGIMAAEAGFICILYANVQSARPLVAPFGGSDARFVTNPYCTAIPATEKHPMFVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGYWKGSGMSIV 232
            S  + G   V +L+G+  P     D +GN T++P V+       +   G  KG G++++
Sbjct: 181 TSTIAMGKARVAQLSGKPAPEGALIDAQGNATRDPSVVFDGAGGALTAFGQHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            D++    S G + A   ++  D    + + I I+ +      +    +    D+V ++ 
Sbjct: 241 GDILGGSFSGGGAYAP-EREVPDRIVNNMMAILIDPNVFGLAQSFGVDVDSYTDWVKASP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A     ++ PG       AE    GI +D    A++ A
Sbjct: 300 AAPGTAGVQFPGDPERRSTAERSAKGIPLDAGTLAQLTA 338


>UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organisms RepID=LDH_RALEH
          Length = 349

 Score =  321 bits (823), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 78/340 (22%), Positives = 146/340 (42%), Gaps = 10/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++    +     +L ++ V ++ AD  AE    +   G  SHG++  P +   L+   
Sbjct: 1   MKISLTSARQLARDILAAQQVPADIADDVAEHLVESDRCGYISHGLSILPNYRTALDGHS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  + K +   G +  +D     G    K +M  AIE    HG  +V LR ++H  R 
Sbjct: 61  VNPQGRAKCVLDQGTLMVFDGDGGFGQHVGKSVMQAAIERVRQHGHCIVTLRRSHHLGRM 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMS 174
           G YG  AA  G++ + +TN      V+ P+G +  R+ TNPL  A P     P  +VD++
Sbjct: 121 GHYGEMAAAAGFVLLSFTNVINRAPVVAPFGGRVARLTTNPLCFAGPMPNGRPPLVVDIA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIV 232
            S  +     V    G   P       +GN T +   +  E    +LP G  KG  + +V
Sbjct: 181 TSAIAINKARVLAEKGEPAPEGSIIGADGNPTTDASTMFGEHPGALLPFGGHKGYALGVV 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A +LS G ++ +           +   + +     +    + A+++  + Y+    
Sbjct: 241 AELLAGVLSGGGTI-QPDNPRGGVATNNLFAVLLNPALDLGLDWQSAEVEAFVRYLHDTP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            A     ++ PG       A+   + + ++ ++W  ++ L
Sbjct: 300 PAPGVDRVQYPGEYEAANRAQAS-DTLNINPAIWRNLERL 338


>UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine bacterium EB0_35D03
           RepID=A4GHI0_9BACT
          Length = 335

 Score =  320 bits (822), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 74/338 (21%), Positives = 147/338 (43%), Gaps = 14/338 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++++ ++        L +     E A   A+        G   HG++R P +++Q+  G 
Sbjct: 5   LQISEKEAWDLAFNALTNNQTSDENAKEVADALINAEFDGQAGHGLSRIPSYVEQVIAGK 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +     P  ++S G++ + DA            +    +     GI   ++  ++H+ + 
Sbjct: 65  VAGKVSPSILSSKGSVIRVDANHGFAFPAISLALSEITKTCKSFGIAAASISRSHHFGQA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G +  + AE G IG+ + N+   +PPWG  +   GTNP+  A P  S+   ++DMS+S  
Sbjct: 125 GRHVERLAEVGLIGLMFGNTPKAIPPWGGTQALFGTNPIAFASPRDSSVPLVIDMSLSKV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V      ++P D   D +G  T +     +   +LP+G  KGS ++++++++A 
Sbjct: 185 ARGKVMVANQLNEKIPEDWAIDKDGKPTTDAKKALEG-AMLPIGDAKGSALALMVEVLAA 243

Query: 239 LLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+      E +       D  G+ Q+ IAI+      G +   + + ++  V       
Sbjct: 244 GLTGSNFGFEASSFLNAEGDAPGVGQLIIAIDPS-FFSGESFGERTETLVGAVLEQP--- 299

Query: 296 ENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
                RLPG +         +   IT+   ++ KI+ L
Sbjct: 300 ---GTRLPGDKRIEKRKVREKSETITISKDLYEKIERL 334


>UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID=B7VQB6_VIBSL
          Length = 333

 Score =  320 bits (822), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 151/331 (45%), Positives = 218/331 (65%), Gaps = 2/331 (0%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V+ E+L+  + R+L++R +  E A   A  F      G YSHG+NRFP FI Q++ G I 
Sbjct: 4   VSTEKLQQEYERILLARDMKPEMATKLAAGFVEMANEGTYSHGINRFPVFIDQVDKGQIK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            +A+P+ + S+GA+EQWD     G L      +RA+ELA D+GIG+V +RN+NHWMRGG+
Sbjct: 64  LNAEPECVNSMGALEQWDCNYGPGVLNGLICAERAMELARDYGIGMVGMRNSNHWMRGGA 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM 182
           Y  + A +G+ GI  TNSIAVMP WG K+ R+G+NPLI+A+   P  +VD SMS FSYG 
Sbjct: 124 YVLKMAREGFAGIASTNSIAVMPAWGGKDHRVGSNPLIMAVAGDPPVVVDCSMSQFSYGQ 183

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           L+   LA ++LPV GGFD+EG LTK+P V+ +N+R+LPMG+WKGS M+IVLDM+ T ++ 
Sbjct: 184 LQNFVLADKELPVVGGFDNEGELTKDPHVLWENKRLLPMGFWKGSSMAIVLDMMLTAITG 243

Query: 243 GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
           G SV  +T+D   E+G+SQ  IAI++ K +D  T   +++RI DYV  +E A E  ++ +
Sbjct: 244 GHSVPALTEDMGGEFGVSQFLIAIDLSKTMDQSTYAQEMKRIRDYVLESEPA-ETGSVMI 302

Query: 303 PG-HEFTTLLAENRRNGITVDDSVWAKIQAL 332
            G      +       GI ++D +W +I +L
Sbjct: 303 AGSEIENFIKKHEAAGGIEINDGIWEQITSL 333


>UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_DROVI
          Length = 520

 Score =  320 bits (821), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 139/336 (41%), Gaps = 12/336 (3%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           + +   + V  +  V  + A   A+        G  S G++R P     L N  + P  Q
Sbjct: 171 EAQRFVSDVFAAMDVPDDAASEMADALIAADYMGQRSMGIHRLPAIAADLLNLTVDPRMQ 230

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           PK ++   A+   D Q + G + A   MD AI  A + GIG VA R +N       Y  Q
Sbjct: 231 PKLVSERDALALVDGQNAPGPVVANFCMDLAIRKARNQGIGYVAARRSNTIGMASWYTCQ 290

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSYGMLEV 185
           A     IGIC +N   ++ P G  E  +G N +  A  S     ++D+ MS +    L++
Sbjct: 291 ALSHRMIGICMSNGPPILVPCGGSEPLLGGNSIACAAGSKQEQFLMDLGMSAYPIEQLQL 350

Query: 186 NRLAG--RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIATLLSD 242
               G  RQLP     D  G  T       + +R+ P     K  G++ ++D++  +++ 
Sbjct: 351 EYSNGYLRQLPDYLALDSSGKPTNCAAEALRAQRLRPFTPEHKAFGLAAMVDILCGVMTG 410

Query: 243 GASVAEVTQ-----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            +    +        ++    + Q++IAI+  +     + + +L      + +    D  
Sbjct: 411 ASYATHIRHRSLFSSDNKLADLGQVYIAIDPMRF--CVSFEERLADFHQLLRNVIPCDPM 468

Query: 298 QAIRLPGHEF-TTLLAENRRNGITVDDSVWAKIQAL 332
           Q   +PG +    +   + + G+ +  S  + IQ L
Sbjct: 469 QPPLIPGDKELQHMQMVDDQGGLMLSPSTLSVIQEL 504


>UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5SZX1_ACIDE
          Length = 376

 Score =  320 bits (820), Expect = 5e-86,   Method: Composition-based stats.
 Identities = 78/351 (22%), Positives = 149/351 (42%), Gaps = 20/351 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + T E L+A    +L + G+   TA   A +   T   GV SHG++   ++    + G +
Sbjct: 7   RFTAESLRAQTAAILQAWGMPETTAHTTAALMVETDLLGVESHGISMLAQYEAMRDGGRL 66

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+ +    A    D    +G+  + + M  A++ A   GI LV +RN++H+   G
Sbjct: 67  HLAASPRVLRDGPATALLDGDAGLGHAVSAQAMQLAVDKARALGIALVGVRNSHHFGAAG 126

Query: 122 SYGWQAAEKGYIGICWTNSIA-VMPPWGAKECRIGTNPLIVAIP-----STPITMVDMSM 175
            Y   A  +G IG+  +++   ++ P  A E  +GTNP+  A P          ++DM+ 
Sbjct: 127 VYARIAQRQGLIGLVTSSAQGILLVPTRAAEPVLGTNPIAFAAPVSQGSHNNAFVLDMAT 186

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI------EKNRRILPMGY------ 223
           +  +   ++V  L    +P     D +     EP         + +  + P+G       
Sbjct: 187 TTAAANRVKVKALRSEPVPSGWVVDGQSQPVTEPEAARAQVFDQPDGGLTPLGGSSDGGS 246

Query: 224 WKGSGMSIVLDMIATLLSDGASVA--EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKL 281
            KG G++++  ++   L+ GA       +    D   +   FIAI+     +    + +L
Sbjct: 247 HKGYGLALLAQVLGGTLNGGAFAPLYRQSHGPGDPANVGHSFIAIDPRFFGEPGAFEHEL 306

Query: 282 QRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I+D + +   A+  + + + G       AE  R GI +   +  +I+ +
Sbjct: 307 DAILDVLHATRPANPAEPVLVRGDPEAAQHAERARLGIPLPAPLLRQIRDI 357


>UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=C1DFD6_AZOVD
          Length = 372

 Score =  320 bits (820), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 84/346 (24%), Positives = 153/346 (44%), Gaps = 17/346 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV  + L+     VL + G+ +  A+  A +   T  +G+ SHGV+  P +    E G  
Sbjct: 8   KVGADALRELTAAVLAAWGMPAVAAEETAALIVETDLAGIDSHGVSMLPFYETLREAGGW 67

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           +PDA+P+ +         D    +G+ TA + M  A + A   G+G VA+RN+NH+   G
Sbjct: 68  VPDAEPRVVRESPCTALLDGGHGLGHRTAMQAMRLAADKAQGVGLGAVAVRNSNHFGAAG 127

Query: 122 SYGWQAAEKGYIGICWTNSI-AVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
            Y   AAE+G IG+  + +   ++ P  A+   +GTNP+  A P+      ++DM+ +  
Sbjct: 128 LYARAAAERGLIGLVASTTRSPMLVPTRARVPVLGTNPIAFAAPARRNRPFVLDMATTTV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK------NRRILPMGY------WKG 226
           +   ++V  L G+ +P     D+ G          +         +  +G        KG
Sbjct: 188 AANKVKVYDLQGKDIPPGWVVDEAGRPVTAGERAMEYLFRRPEGGLTALGGVAELGSHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
            G+ ++  ++A  L   A  A    D  ++  I   F+A++     D    + +L  I+D
Sbjct: 248 YGLGMLAQILAGPLCGAAFGARREAD--EKPNIGHFFLALDPRAFRDADEFEDELDAIVD 305

Query: 287 YVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + +   AD    + + G           R GI + D + A+++ +
Sbjct: 306 ALHATPAADPALPVLVAGDPEAQTRETRLREGIPLPDRLQAQLREI 351


>UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family protein n=34
           Tax=Enterobacteriaceae RepID=B7UIS0_ECO27
          Length = 336

 Score =  319 bits (819), Expect = 8e-86,   Method: Composition-based stats.
 Identities = 73/336 (21%), Positives = 146/336 (43%), Gaps = 9/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ E LK+  +  L + G+D++T     ++      +GV+SHGV     +  +L  G 
Sbjct: 4   VYVSEENLKSLVHHKLHTAGLDTDTTQQVTDVLVHADITGVHSHGVMCVEHYCTRLAAGG 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    Q        ++   D+   +G+       + AI+LA   G+G V+++N +H    
Sbjct: 64  LNKAPQFSIEQISPSVAILDSDDGMGHSALITATEHAIKLAQQEGLGFVSVKNTSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
             +      KG + I  T +   + P G  E  +GTNP+    P  ++   +VDM+ S  
Sbjct: 124 SYFAEMITNKGLVAIVMTQTDTCVAPHGGAERFLGTNPIAFGFPVENSHPMIVDMATSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   +  G+ +      D  G  T +P  IE    +LP G  KGSG+++ +D +  
Sbjct: 184 AFGKILHAKETGKHIGEGLAIDKNGYGTTDPYKIEN---LLPFGQHKGSGIALAIDALTG 240

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L +         +  D      ++ + IAI+  KL + P     + +++  + + + A 
Sbjct: 241 VLMNANFGNHIVRMYGDYDKMRKLASLVIAIDPKKLGN-PVFAKTMAKMVTELHAVKPAP 299

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +  P         + ++ GI V   ++  +  
Sbjct: 300 GVEKVLAPNDPQMHYKEKCQQEGIPVPAGIFHYLAE 335


>UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VRA6_MARMS
          Length = 349

 Score =  318 bits (817), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 73/340 (21%), Positives = 150/340 (44%), Gaps = 15/340 (4%)

Query: 1   MKVTF---EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE 57
           MK T+    +LK+   ++L   G+  + A   AE+  ++ E G  +HG++  P +I +L+
Sbjct: 1   MKFTYFNRNELKSLGTKLLSQYGMPDDRASITAELLIQSDELGFTTHGLSLIPYYIPELQ 60

Query: 58  NGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHW 117
            G +        +   G+   W+AQ   G     K MD A     +HG+   ++  A+H 
Sbjct: 61  AGKMQEADDVVVVNDTGSTFVWNAQYLPGIWMMNKAMDEAFSRVKEHGVVTASINRAHHI 120

Query: 118 MRGGSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPST-PITMVDMS 174
               +Y   A +K  I I  T+  A  ++ P+G  +  +  NP  +  P+     ++D  
Sbjct: 121 GCLSTYVKLATDKNLICIVSTSDPAGKLVAPFGGIDPVLTPNPWAIGYPTNGDPVIIDTV 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMS 230
            S+ ++  +  +   G  +P     D  GN T +  VI     ILP+G      +G   S
Sbjct: 181 TSICTFSKVREHLNTGLPMPYPMLQDKNGNETTDATVINDGGAILPIGGTDYGHRGYCFS 240

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           I+++M+   LS      +V++     +G +     I+ +          ++ ++ +   +
Sbjct: 241 IMVEMLTQGLSGHGRADDVSR-----WGGNVYIQLIDPEAFAGLEAFKEQMDKLTELCLA 295

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +   +E + +R+PG    +   +++  GI ++D    +++
Sbjct: 296 SRPREEGKPVRVPGQFGLSCAKQSKTQGIRLNDETLDRLK 335


>UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadecabacter antarcticus
           238 RepID=B5KEU8_9RHOB
          Length = 365

 Score =  317 bits (814), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 76/344 (22%), Positives = 150/344 (43%), Gaps = 15/344 (4%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           T + +KA    +L++ G+ ++     AE        G+ +HG++    + +    G    
Sbjct: 7   TPDSIKAQATEILVNWGMSADNVALTAEGMLDCDLRGIDTHGISLLALYDKWRVGGGFAL 66

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
           DA  K +    +    DAQ  +G   + + ++ A   A + G+  V +RN+ H+   G Y
Sbjct: 67  DATDKLLRDGPSYASIDAQGGLGFPVSVRAVELACNKARETGLAAVTVRNSRHFGAAGYY 126

Query: 124 GWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
               AEKG + +  T++ +  M P GA +  +GTNPL  A+P       + DM+ S  + 
Sbjct: 127 ARLGAEKGMMMLVATSTKVVCMVPPGAADAVLGTNPLAYAVPRQNGAPVVFDMATSTAAG 186

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI------EKNRRILP------MGYWKGSG 228
             + + +L+   +P     D EG    +P +        +   + P      MG +KG G
Sbjct: 187 NKIRLYQLSNTPVPEGWVVDHEGKSVTDPDIASDIVYGSRPGGLTPLGATPGMGAYKGYG 246

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           ++++   +   L+ G       +       I   F+A++  K  D    +A +  + D +
Sbjct: 247 LALMGHFLGGTLAGGDFAGSKNRAADASDNIGHFFLAMDPAKFRDLAAFEADMCDVDDSL 306

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +    D ++ I LPG     +  + R+ GI + D++  +++ +
Sbjct: 307 RATPAVDPDRPILLPGDVERKVADQRRKAGIPLADALVDQLKRI 350


>UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C467_9PLAN
          Length = 356

 Score =  316 bits (811), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 78/335 (23%), Positives = 150/335 (44%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++    LK    ++ +  G+    A+  A+        G++SHG     R++  ++ GD
Sbjct: 16  VQIPLGPLKELLVKLFVRMGMFEVEAEIAADRLIEADLRGIHSHGSRTAERYLDSMDMGD 75

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQ   +    AI   D  +S+G++ A + M+ AI+ A + G G V ++N++H+   
Sbjct: 76  IDPRAQILTLKETPAIAVLDGSKSMGHVAATRAMELAIKKAGEVGTGTVVVKNSHHFGAA 135

Query: 121 GSYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
             Y   A + G IG C TN+  A +   G+ +     N +   +P+      ++DM+ + 
Sbjct: 136 AVYVLMAVKAGMIGYCTTNTGRATVAAHGSTQGATANNAIAWGVPTREGAPFVLDMACAK 195

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            S+G LE   + G  +P     D+EG  T +   +   + +LP    +G G+++V  ++ 
Sbjct: 196 TSWGKLETQAMYGLPVPPGYALDNEGKETTDSSTV---KTLLPAAGPRGYGLAMVSSILT 252

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             L+ G      T+    E G    F  I++ + ++     A+L   +  +      +EN
Sbjct: 253 GALAGGKLPINKTKPPEIE-GSEHFFYVIDLKQFVEEEHFHAELDSAIKAIHQLSTVNEN 311

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +RLPG         +   G+ V       ++ L
Sbjct: 312 EPVRLPGELEWEQTQRSLSEGLLVHRDHANLLKEL 346


>UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaproteobacteria
           RepID=B8IDJ1_METNO
          Length = 378

 Score =  315 bits (807), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 79/346 (22%), Positives = 140/346 (40%), Gaps = 21/346 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +    L A    + +  G  +E A            +G  SHGV R PR++  L  G+
Sbjct: 21  MLIAAAGLTAFVRDIFVGEGCSAEEAGRIGRYLVAANLTGHDSHGVIRVPRYVGWLRAGE 80

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++ D  P+ ++   A    DA    G        +  I  A  +G+ +VALR+A H  R 
Sbjct: 81  VVADRAPEVVSDSAAFVLVDAHYGFGQTAGPFATELGIARARQNGVAIVALRHAGHLGRI 140

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMS 176
           G +  QAA  G + + + N     ++ P+G+ + R  T P     P       ++D + S
Sbjct: 141 GEWAEQAAAAGLVSVHFVNVAGSLLVAPFGSVDRRFSTAPFAAGFPVAGAEPIILDFATS 200

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-------------KNRRILPMGY 223
             + G + V    G+ LP     + +G L+++P  +                  I   G 
Sbjct: 201 AVAEGKVLVASQGGKPLPEGVLIEPDGRLSRDPRTLFGPIEGTAERDSRRGEGAIRAFGE 260

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KGSG++++ ++IA  L+   +           +    + I +  +    G    A+ + 
Sbjct: 261 HKGSGLALMCELIAGALTGSGTAGP----GPKRFCNGMLSIYLTPEAFGSGDAIAAETRT 316

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +D+  SA  A  +  + LPG       A+    G+ + D VWA +
Sbjct: 317 YLDFFKSARPASPDGEVLLPGEPERRTRAQRLAEGVPLPDPVWATL 362


>UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholderiales
           RepID=Q0K2P1_RALEH
          Length = 367

 Score =  314 bits (805), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 71/337 (21%), Positives = 142/337 (42%), Gaps = 10/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++    L      + ++ G  ++ A   A+       SG  SHGV   PR++   +  ++
Sbjct: 5   RIPTAALHQWVADLWLAAGSSAQEARLTADHLVGANLSGHDSHGVGMIPRYVLAWQADEL 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             + Q   +   G++   D  R +G     + M+ AI  A +HG+ ++ LR ++H  R G
Sbjct: 65  QLNQQVSVLHDAGSMLSLDGNRGMGQAVTAQAMNMAIGRAREHGVCVMGLRQSHHLGRVG 124

Query: 122 SYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSM 177
            +  QA   G I I + N  S  ++ P G  + R GTNP  + +P    P  ++D + S 
Sbjct: 125 HWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARYGTNPFTIGVPVAGEPPLVLDFATSA 184

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI-----EKNRRILPMGYWKGSGMSIV 232
            + G + V    G  +      D  G  + +P V+          + P G  KG  ++++
Sbjct: 185 IALGKVRVAHNKGVPVAPGCLLDAHGEPSADPAVMYPADGAPQGALRPFGEHKGHVLAVM 244

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++   ++ G ++   T  +      + + I  +  +L +  +   ++    D++ ++ 
Sbjct: 245 CELLGAAVTGGHTIRPETLRHEHAVWNNMLAIVFDPARLGNSTSFGHEVAAFADWMKASR 304

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
                  IRLPG       A    + + VD    A++
Sbjct: 305 LQPGQDGIRLPGEPERAWRAARATH-MPVDAGTLAQL 340


>UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis S4
           RepID=B9K4F6_AGRVS
          Length = 349

 Score =  314 bits (805), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 79/336 (23%), Positives = 143/336 (42%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++ FE L+    R+ ++ G     A+  +   A     G  SHG+ R P ++  + +G +
Sbjct: 13  RLPFEALQNLLKRIFLAAGASEHVANILSANCAGCERDGALSHGIFRMPGYVSSIRSGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A P   T      + DA+     +          E A   GI L+++RN++H+    
Sbjct: 73  DPAAVPVLETGGSGFLRVDARNGFTQVALDFAAQSLKERARQEGIALLSIRNSHHFSALW 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
                 AE+  + I   NS A   P+ AK    GTNP+  A P       +VDM+ S  +
Sbjct: 133 PDVVPFAEERLLAIAMVNSFACTAPFDAKVPVFGTNPVAFAAPCDGMVPMVVDMATSAIA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +++    G  LP   G D  G  T +P  +     +L  G +KGS +S+++++++  
Sbjct: 193 NGDVQIAAREGFSLPPGLGIDRSGKPTVDPHAVLDGGALLTFGGYKGSAISMLVEVMSAA 252

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+ G    EV       +      Q+ I I+ D          +++ +++ +  A+ +  
Sbjct: 253 LTGGKFSYEVDWSDYPGAQTPHTGQLVILIDPDV-GRNAQFSRRVRHLVERLRLAKVS-- 309

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG         + R G+ +  S   +++ L
Sbjct: 310 ----RLPGDRRLVTRERSMREGVCLQKSDLERMELL 341


>UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria RepID=B0UBJ7_METS4
          Length = 351

 Score =  314 bits (805), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 86/313 (27%), Positives = 148/313 (47%), Gaps = 5/313 (1%)

Query: 24  ETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQR 83
           + A  CA+   +    G  SHG+ R   +  +L  G   P A P+ +   G +   D + 
Sbjct: 27  QDAALCADSLVQADLWGHQSHGMMRLSWYAARLAAGVCDPRAVPESVVDAGGLAVIDGRE 86

Query: 84  SIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAV 143
           ++G + A + M  A+  AA HGIG VA+RN+NH+     +   AA  G IG   TN+   
Sbjct: 87  AMGQVVAAQAMAEAMARAAAHGIGAVAVRNSNHFGTAMYFTLMAARAGCIGFLSTNASPA 146

Query: 144 MPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDD 201
           M PWG +   +G NP   A P+      ++D++ +  + G + + R  G  +P+    D 
Sbjct: 147 MAPWGGRRKALGNNPWSWAAPAGRHAPLVLDIANTAVARGKIYLARQRGEAIPLGWAMDA 206

Query: 202 EGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQD--NSDEYGI 259
            G  T +P     +  ILPM   KGS +S V+D+++ +L+  A  A V          G 
Sbjct: 207 SGRPTADPQAAI-DGLILPMAGHKGSAISAVMDVLSGVLTGSAFGAGVAGPYQAERRSGA 265

Query: 260 SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGI 319
             + +AI++ ++      +A+++R +  + +   A+  +A+  PG       AEN R G+
Sbjct: 266 GHLALAIDIARIQPLAEFEARMERFIAEMRAVPLAEGAEAVFYPGEIEARAEAENLREGV 325

Query: 320 TVDDSVWAKIQAL 332
            + +   A +  L
Sbjct: 326 LLPEDTRADLLRL 338


>UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Acidobacterium
           capsulatum ATCC 51196 RepID=C1F8E3_ACIC5
          Length = 334

 Score =  311 bits (797), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 147/333 (44%), Positives = 205/333 (61%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ F+ L  AF   L   G   E A+ CA +FA TT  GVYSHG NRFPRF+  + NG 
Sbjct: 2   LRIPFDDLHRAFIAALTHVGFTPERAELCARLFAETTLDGVYSHGANRFPRFLAMIRNGA 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+ +++ GA+E+WD +R  GNL A   M+RA+ L+  HGIG +ALRN NHWMRG
Sbjct: 62  VDVHATPQCMSAFGALERWDGRRGPGNLNAHAAMERALALSRTHGIGCLALRNTNHWMRG 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFS 179
           GSYGWQAA  G I +CWTN++  +P WG +E  +G NPLIVA+P      ++DM+MS FS
Sbjct: 122 GSYGWQAANAGSIALCWTNTMPNLPAWGTREASVGNNPLIVAVPRRAGHLVLDMAMSQFS 181

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE        LP+ GGFD  G LT +P  IE ++R LP+GYWKGSG++++LD +A +
Sbjct: 182 YGALESYSRRSELLPIPGGFDASGTLTNDPAAIEASQRPLPIGYWKGSGLALLLDAVAAM 241

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
            + G +  ++ +D   E G+SQ+FIAI    L      +     I+  + +A   D  + 
Sbjct: 242 TALGNATHQLARDPLQETGLSQMFIAIHPAALDAAADANHLADEIVASLHAAAPVDPGRP 301

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            R PG +   L  EN R GI V+D +W +I A+
Sbjct: 302 ARYPGEQTLRLREENLRLGIPVEDVIWQQILAV 334


>UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS
          Length = 384

 Score =  310 bits (795), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 72/336 (21%), Positives = 134/336 (39%), Gaps = 8/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  E+ +      L   GV        +E        G+Y  G+++   ++  L +    
Sbjct: 35  VHVEEARRFIRDCLKRIGVPELKLRCVSEFLVAADYRGIYGSGLSQLDIYLNDLLHRRAN 94

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+ I    A    +   ++G +     M  A+E A + G+G V    +N+      
Sbjct: 95  MDAEPEIIRETVATAHVNGNDALGVIVGNFCMSLALEKAKNVGVGFVVANRSNNLGIASW 154

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFSYG 181
           Y  QA ++ Y G+  +N   +M P  +    IG N L   +       M+DM  SM   G
Sbjct: 155 YALQALDQDYAGLVMSNGAPIMVPPRSSVASIGANCLAFGVKGRNSYFMLDMVSSMKDIG 214

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +E        +P     D+ G  T  P +  +N R+   G  KG  ++ ++D++  +LS
Sbjct: 215 SIEWALTKHEYIPHLWAADERGYSTCFPMLALRNPRLTCAGASKGYCLAAMIDLLCGVLS 274

Query: 242 DGASVAEVTQDNSDE----YGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                 ++    S+       + QIFI I+ D     P    +L    + + ++  A   
Sbjct: 275 GANFSTQIPPWRSNVKRLCPNLGQIFIVIDPDFF--LPDFMDRLDDFTECIKNSTPASLA 332

Query: 298 QAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
           + I++PG      +    + G +   +++  K  A+
Sbjct: 333 KPIQMPGDREMRHMHLVEKLGALPYHNALLKKYNAI 368


>UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME
          Length = 461

 Score =  310 bits (794), Expect = 6e-83,   Method: Composition-based stats.
 Identities = 77/340 (22%), Positives = 142/340 (41%), Gaps = 12/340 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +   ++V  +  V  + A   A+        G  S G++R P     L N  + 
Sbjct: 96  VDVLEAQRFVSQVFSAMQVPKQAASEMADALIAADYMGQRSMGIHRLPSIAADLLNCTVA 155

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA P  ++   AI   D   + G + A   MD A++ A + GIG V+ R++N       
Sbjct: 156 GDATPGIVSEKKAIALVDGHNAPGPVVANFCMDLALQKAREVGIGWVSARSSNCIGFASW 215

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFSYG 181
           Y  QA E+  IG+C TN+   + P G  E  +G NP+  A        + D  M+  S  
Sbjct: 216 YACQALEQRMIGLCMTNAAPTLVPAGGIEPVLGENPIACAASGVHEQFVADFGMAACSVD 275

Query: 182 MLEVNRLAG--RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIAT 238
            LE++   G  +Q+P     D  GN T       + +RI       KG G++  +D++  
Sbjct: 276 ELELSYCNGWSKQVPKLVALDRNGNETTSTEEALRAQRIRAFQPEHKGFGLAAAVDILCG 335

Query: 239 LLSDGASVAE-----VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           +++      +     V    +    + Q+++AI+  +    PT + +L      +  A  
Sbjct: 336 VMTGARYANQIQRRGVYSTENAPANLGQVYVAIDPMRF--CPTFEDRLADFHRLLRQAVP 393

Query: 294 ADENQAIRLPGHEF-TTLLAENRRNGITVDDSVWAKIQAL 332
           +   +   +PG +    +   + + G+T+     + ++ L
Sbjct: 394 SKVGKPPMVPGDKELQHMKMVDEQGGLTMSSCTLSVLEEL 433


>UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriaceae
           RepID=B7UPM1_ECO27
          Length = 357

 Score =  309 bits (792), Expect = 9e-83,   Method: Composition-based stats.
 Identities = 90/336 (26%), Positives = 158/336 (47%), Gaps = 14/336 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+++     +L   G D++ A   AE        G  SHGV   P++++ +  GD
Sbjct: 3   LQIAVEKVRWLAAGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGD 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P+ +TS G ++++ A    G    K  ++ AIE     G  L+ L +A+H  R 
Sbjct: 63  VTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQTKHRGFCLLTLCHAHHLGRM 122

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMS 174
           G YG   A++G   +  +N     A++ PWG  E R+ TNP   A P     P  +VD +
Sbjct: 123 GHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFA 182

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIV 232
            S  +     V    G+Q       D +GN + +PGV+  N    +LP G  KG G++++
Sbjct: 183 TSSMALNKARVMSSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALM 242

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIF-IAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++M+A +LS G ++AE  Q +   +    +F + I+ D+  D      +     DY+ + 
Sbjct: 243 IEMMAGILSGGDTIAEDHQTDGSAHN--HLFALIIDPDQFTDLAGEKGQF--FADYLLAT 298

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
           +       +  PG         N +  IT+  S W+
Sbjct: 299 QPQPGGNPVIYPGMPEAANRERNAKM-ITIPVSFWS 333


>UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricaulis maris MCS10
           RepID=Q0ART3_MARMM
          Length = 355

 Score =  308 bits (791), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 78/339 (23%), Positives = 141/339 (41%), Gaps = 10/339 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++    L A    VL+  G   + A+  A         G  SHGV   P +   +  G +
Sbjct: 7   RLDAPNLTAFCTAVLVRAGARVDDAECVARHLVEANLKGHDSHGVGILPAYAGHIRRGQV 66

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             DA    +T    + + DA    G    ++++ +A   A   G+    L NA+H  R G
Sbjct: 67  CLDADDTVLTDTTVLLRVDAGGGWGAPAGQRLIHQAGAKAKSGGLAAATLGNAHHLGRIG 126

Query: 122 SYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSM 175
           +Y  QA+E G I + + N      ++ P+   + R GTNP+ +  P+T   P  ++D++ 
Sbjct: 127 AYAEQASEAGLISMHFVNVTDHAPLVAPYRGSDARFGTNPVCIGFPATDTRPAFLLDIAT 186

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI---EKNRRILPMGYWKGSGMSIV 232
           S  + G   V    G  +P     D +G  T +P  +   E    + P+G  KG G++  
Sbjct: 187 SQIALGKARVAANKGLPVPAGSLIDKQGRPTTDPSGMSGFEIEGALTPLGKHKGYGLAFA 246

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A +L    ++ +     S     S   I I+ D   D     A+   +  Y  ++ 
Sbjct: 247 CELLAGVLGGAGTI-QPDHPRSGGLKNSMFSILIDPDAFGDRAWMQAETDAMARYALASP 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             D +  +  PG     +  +  + GI +D+    ++ A
Sbjct: 306 PMDWDSPVLYPGDPERAIAGKRGKEGIPLDEVTIGQLNA 344


>UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0SCF8_RHOSR
          Length = 358

 Score =  308 bits (791), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 139/335 (41%), Gaps = 9/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  ++ +   +  L+  GV  + AD  A     T+  G+ +HG+   P+++ +L  G   
Sbjct: 12  IDEQEARWLASTALVEAGVPEDDADLVAAALVDTSLRGIDTHGLRLLPQYLDELATGVAN 71

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A P  +   GA    DA  ++G L        A + A   G+  V +RN+NH+     
Sbjct: 72  AAACPTVVRDRGAGLLLDADGALGVLAGLAATRLAADRAKAFGVAAVGVRNSNHFGAASV 131

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYG 181
           Y    A +G IGI  T++ + + P+G  E   GTNP+ VA  +    + +DM+ S   +G
Sbjct: 132 YTRHLAGQGMIGIAVTSAASRVAPYGGVEPLFGTNPISVAAGTGDDGLALDMATSQVCFG 191

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            ++  R  GR L      D  G  T EP        + P+G +KG G+++ + ++  +L+
Sbjct: 192 EVKHRRAEGRPLGSGWATDRGGLPTAEPDEAY---ALSPLGGYKGQGLAMAVTLLGAVLT 248

Query: 242 DGASVAEVTQ----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                 ++ Q          G+    +A++           A L  ++D V  +  A   
Sbjct: 249 GSPPDWQLEQVGEGTPGRSRGVGHFVLALDPGAFSGHAHFAAGLADLLDTVRGSTPATGT 308

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  PG        E R  GI +D         L
Sbjct: 309 -PVVAPGDPQRAHERERRVRGIPLDPRTAEIFATL 342


>UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=5 Tax=Klebsiella
           RepID=B5Y2B5_KLEP3
          Length = 336

 Score =  308 bits (790), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 80/337 (23%), Positives = 150/337 (44%), Gaps = 11/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + ++  +       VL + G  ++ A A A         G  SHG+ R    +  L  G 
Sbjct: 4   VTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PDA+P+      AI + DA  +   L  ++ +   +E A  +GI  +A+    H+   
Sbjct: 64  VSPDAEPQIHDQAPAIARADAGGAFSLLAYERALPLLLEKARQNGIAALAINRCVHFSAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
            +      E G +G+  T S A + P G      GTNP+    P       +VDM+ S  
Sbjct: 124 FADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTNPIAFGWPRRDKQPFIVDMATSAA 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +++++ AG+ LP   G D +G  T +   +  N  +L  G  KGS ++ +++++A 
Sbjct: 184 ARGEIQLHQRAGKALPQGWGIDSQGQPTTDAAEVL-NGAMLTFGGHKGSALAAMVELLAG 242

Query: 239 LLSDGASVAEVTQDNSDEYGI---SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L    + AE    ++   G+    ++ +A++  + +      A+ Q  +    +   A 
Sbjct: 243 PLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLG-----AQAQEQLARAETLFNAM 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++Q  RLPG        ++ + G+T+  S+  +I AL
Sbjct: 298 QDQGARLPGERRFACRQQSEQQGVTISRSLHDEICAL 334


>UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteobacteria
           RepID=Q46VE5_RALEJ
          Length = 338

 Score =  306 bits (784), Expect = 9e-82,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 148/336 (44%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  E+L+      L   G     + A A    R    G+ SHGV+R P ++  L +  +
Sbjct: 3   RIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P   ++  +    DA         +  +  A+  A + G+G+ A+ N++H+   G
Sbjct: 63  DGQAVPTVRSTRASAVLVDAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
                 A  G +GI   NS A MP WG K    GTNP+  A P       ++D+S+S  +
Sbjct: 123 LPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIAAAFPRQGRLPVLIDLSLSEVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T 
Sbjct: 183 RGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRG-SMLPAGGVKGAMLALMVELLVTT 241

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+    GA       D  +   I Q+F+ ++            +++ ++  +       +
Sbjct: 242 LAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVML------D 295

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +   RLPG     L  E +++GI + ++  A++ +L
Sbjct: 296 DTGTRLPGARRYALQTEAQQHGIEIPEAQLAELLSL 331


>UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NGA8_DROWI
          Length = 502

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 74/339 (21%), Positives = 139/339 (41%), Gaps = 15/339 (4%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           + +   + +  +  V  + A   A+        G  S G++R P     L N  +   A+
Sbjct: 148 EAQRFVSDIFAALDVPQDAASDMADALVAADYMGHRSMGIHRLPAIAADLLNCTVSAIAK 207

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P+      A+   +   + G + A   MD AI+ A   GIG V  R +N       Y  Q
Sbjct: 208 PEIQKENDALALVNGSNAPGPVVATFCMDLAIQKAQQVGIGWVVARKSNCIGMASWYACQ 267

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL-IVAIPSTPITMVDMSMSMFSYGMLEV 185
           A EK  IG+C +N+   + P G  E  +G NP+  VA       +VD   S  S   LE+
Sbjct: 268 AMEKRLIGLCMSNAAPTLVPSGGIEPILGENPIACVAAGEHEQFLVDFGQSSCSVDQLEL 327

Query: 186 NRLAG--RQLPVDGGFDDEG-NLTKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIATLLS 241
           +   G  ++LP     ++ G   T +     + +R  P    +KG G++ ++D++  ++S
Sbjct: 328 SYCNGKLKELPPALALNESGEQDTNDVAEALRAQRFYPFRPAYKGFGLAAMVDILCGVMS 387

Query: 242 DGASVAEVTQDN-----SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
                 ++ +       +  Y + Q+++AI+  +     T + +L      + +A     
Sbjct: 388 GAQYANQLRKRGIFSTENKPYDLGQLYVAIDPRQF--CTTFEDRLADFQHLLRNAMPCPV 445

Query: 297 N--QAIRLPGHEF-TTLLAENRRNGITVDDSVWAKIQAL 332
              + I  PG +    +   ++  G+ +       +Q L
Sbjct: 446 GCKEQIMAPGDKELLHMQMVDKEGGLRISPCTLGILQEL 484


>UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B6BPN1_9RICK
          Length = 332

 Score =  303 bits (778), Expect = 4e-81,   Method: Composition-based stats.
 Identities = 71/337 (21%), Positives = 147/337 (43%), Gaps = 14/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T +++     + L++ G + ETA   +E+       G  SHG+ R P ++  L++G 
Sbjct: 4   VSLTLDEIFNLAKKTLVANGCNDETASILSELIKNAERDGSLSHGLFRLPAYVSGLKSGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I     P+      ++ + +    +  +   K +    + A ++G+ ++A+ N++H    
Sbjct: 64  INGKGTPEVKRISPSVIKIEGNNCLAPVVLNKGLPELAKAAKENGVAVLAINNSHHMAAM 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMF 178
                + AE G +    T+    + P GA +   GTNP+  A   P     + DM+ +  
Sbjct: 124 WPETEKLAEDGLVAFACTSYKPAVAPAGAIKPLFGTNPISFAWPRPGKTPVVYDMATASM 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G ++V +  G ++P+  G   +G  T +PG I     +LP G +KGS ++++++++A 
Sbjct: 184 AMGEVQVAKREGHKVPLGTGLTKDGKETTDPGEIADGGVLLPFGGYKGSAIAMMVELMAG 243

Query: 239 LLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L       E  +   ++       +  +AI  DK   G +         D + S     
Sbjct: 244 ALVGDNFSYETAEKDNNDGGPPSGGEFILAICPDK-TAGTSWQKHSDEFFDKMKSM---- 298

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +RLPG        +       +++ +  KI++L
Sbjct: 299 --GDVRLPGERRHKNRQDTGPR--NINEELVNKIKSL 331


>UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochloris marina
           MBIC11017 RepID=B0C6P9_ACAM1
          Length = 355

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 81/332 (24%), Positives = 143/332 (43%), Gaps = 7/332 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V+  QL+A    VL +  + SE A A  +   +    G+ SHG+ +   + + L +G 
Sbjct: 5   IQVSAAQLRAFLTAVLANYPLQSEAATAITDHLVQANLWGMDSHGLQQIMGYDKSLRSGR 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  +    T    + + +A R+ G    +  M +AI  A + G+ +V + N+NH+   
Sbjct: 65  INPQPKLHIQTDRPTMIRIEADRAPGQYAGQIAMQQAITKAQEMGMAVVGVTNSNHFGMA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           G Y   AA  G IG   +++  V + P+G KE R+G NP    IP+     ++DM+    
Sbjct: 125 GYYTRMAAAAGMIGFATSDTNVVDLAPYGGKEARLGNNPFSWGIPNGDMPIVLDMAAGTV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           S G ++     G  +P + G    G  T E   +  N+   P    KG+GM++V D++  
Sbjct: 185 SGGKIKHFGYQGLPIPPEWGLTAAGETTSEAQAVAVNQAASP----KGAGMALVADLLCG 240

Query: 239 LLSD-GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L    A++ +    +    G    F  +++    D      ++   +  +    R D  
Sbjct: 241 PLLGTAAALFKTKSRHDRMNGTGHFFWVMDLAVWSDPEEFAERVGDAIATLKQTPRLDPQ 300

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           Q I  PG             GI V  ++   +
Sbjct: 301 QPIYFPGELEVVTEQTRIHQGIPVPYALIQDL 332


>UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=cellular organisms
           RepID=Y1252_PSEAE
          Length = 334

 Score =  303 bits (777), Expect = 6e-81,   Method: Composition-based stats.
 Identities = 71/340 (20%), Positives = 141/340 (41%), Gaps = 17/340 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++++    R+L           A A+           SHG+ R    I  L+ G 
Sbjct: 2   IRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGK 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA+P+       + + DA         +  +   +E A   GI  +A+    H+   
Sbjct: 62  VSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHFSAL 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
                   E G + +  T S A + P G ++   GTNP+    P    P  + D + S  
Sbjct: 122 WVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFATSAV 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G ++++  AG+ +P+  G D++G  T +     +   +L  G  KGS ++ +++++A 
Sbjct: 182 ARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALRG-AMLTFGGHKGSALAAMVELLAG 240

Query: 239 LLSDGASVAEV----TQDNSDEYGISQIFIAIEVDKL--IDGPTRDAKLQRIMDYVTSAE 292
            L    + AE         S  YG  ++ IAI+  ++         A+ + + + +    
Sbjct: 241 PLIGDLTSAESLAYDEGSRSSPYG-GELLIAIDPRRMLGASAEEHLARAETLFEGIVE-- 297

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                Q  RLP          + R+G+T+ +++  ++ AL
Sbjct: 298 -----QGARLPSQRRFEARERSARDGVTIPEALHRELLAL 332


>UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C3W7_9FIRM
          Length = 317

 Score =  303 bits (777), Expect = 6e-81,   Method: Composition-based stats.
 Identities = 81/310 (26%), Positives = 136/310 (43%), Gaps = 9/310 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
             F + K      L   G+D   A+  A+ FA     GV SHG       I++L+ G   
Sbjct: 5   FDFYKEKKKVITELTKHGLDEIQAEVVADCFATADLYGVTSHGCAMTQAHIKRLKCGGYN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                K +    A    D   S G ++A   ++ AI+   D G+  V  RN N +     
Sbjct: 65  LKPDFKIMRETDAFAVVDGDNSFGPVSAMFCLNLAIKRCKDSGVYTVFSRNNNTFGPAFY 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFSY 180
           Y  +AAE+GYI    +NS A M P G KE  +GTNP  V I  P     ++DM+ S+ + 
Sbjct: 125 YSLKAAEQGYIAFICSNSPAQMAPIGGKEKMLGTNPFAVVIPVPGHDPVIIDMATSVVAK 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
              +  + AG+ LP     D +G  T  P    +   +LPM  +KG G+++++D+++ +L
Sbjct: 185 SKFKQYKEAGKLLPNGWALDKDGKPTNAPDEGIQG-MVLPMAGFKGYGIAMLIDIMSGVL 243

Query: 241 SDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           S  A    V     ++     +      I+   +      D  +   ++ + +++   + 
Sbjct: 244 SGAAYLNKVGRFYSEDGSGMNVGFYMTVIDPVAV--LEEYDEIITDFINRLKTSKPGVDG 301

Query: 298 QAIRLPGHEF 307
           + I LPG + 
Sbjct: 302 K-IILPGDDR 310


>UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=3
           Tax=Alphaproteobacteria RepID=B6IQH9_RHOCS
          Length = 339

 Score =  301 bits (771), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 78/337 (23%), Positives = 150/337 (44%), Gaps = 13/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++ +      L++     +TA A A    +    G   HG++R P +  Q  NG 
Sbjct: 6   IRMTLQEAEGLAMDALVACRTSPDTARATARALVQAEADGQKGHGLSRVPCYAAQSRNGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A+P       ++ + DA            +     LA   GI L  +  ++H+ + 
Sbjct: 66  VDGFARPSVRKLAPSVLRVDAAHGFAYPALDLAVAEIAPLARSQGIALATIHRSHHFGQA 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMF 178
           G+   + A++G +G+   N+   M  WG ++  IGTNP+ +A   P  P  ++DM++S  
Sbjct: 126 GAVVERLADRGLVGLLLGNAPKAMAFWGGRQPMIGTNPVAIAAPVPEGPPLVIDMALSQV 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +   +  G  +P     D +GN T +     K   +LP+G  KG+ +++++++++ 
Sbjct: 186 ARGKVMAAQQVGEPIPEGWALDPDGNPTTDAAAALKG-SMLPIGGAKGAALALMVEVLSA 244

Query: 239 LLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+      E +    D      + Q  +AI+     +G      L R+ D + +  R  
Sbjct: 245 ALTSSHFGWEASSLLDDVGPPPDLGQTLVAIDPAPSSEG----GFLSRMGDLIAAFAREP 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +R PG       A   R GIT+  ++ A+I +L
Sbjct: 301 G---VRPPGSRRLENRARAAREGITLPPTLHAEILSL 334


>UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C320A5
          Length = 360

 Score =  300 bits (769), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 89/330 (26%), Positives = 153/330 (46%), Gaps = 7/330 (2%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L      V    G+ +  A   A         G+ SHG    P +++++  G +    +P
Sbjct: 12  LVERLAAVFSGAGLPAAAARTVATALVDADMRGIPSHGSLLVPMYVERIVKGSVATATEP 71

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +  LGA+   DA  ++G ++A   M  AIE A  HG+G VA+R+A H+     Y   A
Sbjct: 72  ATVADLGAVAVLDAGHALGVISADTAMALAIEKARAHGLGAVAVRHAFHFGGAFRYVQAA 131

Query: 128 AEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGMLEV 185
           A+ G +G+   N+  +MP  G     +G NPL V +P       ++DM++S  + G + +
Sbjct: 132 ADAGMVGVAAANTRPLMPAPGGAHAVVGNNPLAVGVPRAGGEPLVLDMALSEAALGKIRL 191

Query: 186 NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
               GR +P     D +G  T +P V      +LP    KG G+++++D++  +LS GA 
Sbjct: 192 AAQEGRAIPATWATDADGAPTTDP-VAAIAGLLLPAAGHKGYGLALIVDVLTGVLSGGAF 250

Query: 246 ---VAEVTQDNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSAERADENQAIR 301
              V  +  D       +  F+A++V +   D  T  A++  +   VTS   A   + + 
Sbjct: 251 GRSVNGLYADTGVPNDCAHFFLALDVARFAGDLDTFSARVAELSAQVTSPPTAPGVERLL 310

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           +PG       A  R  G+ +D +V A+++ 
Sbjct: 311 VPGQLEAERHAAAREQGVALDATVLARLRE 340


>UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomyces sp. ACTE
           RepID=D1XHT9_9ACTO
          Length = 360

 Score =  300 bits (768), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 84/331 (25%), Positives = 142/331 (42%), Gaps = 7/331 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L      +L   G+ +E A   A++F      GV SHG  R P +++ L  G   
Sbjct: 14  VAAGDLLDFAAALLEKGGLCAEDARTTADVFVWAARRGVDSHGTARVPAYLELLAKGVAN 73

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
              +    ++  A    DA R+ G +   +    A++ A  +GI  V +R   H    G 
Sbjct: 74  ARPEITVESTTPAAAVLDADRAPGPVALTRAAREAVDRARTYGIATVGVRRTVHTGAIGY 133

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y  + AE+G +GI + + +  M   GAK   + T+PL VA+P+T     ++DM+ +  + 
Sbjct: 134 YVSRIAEQGLVGIGFVSGMPNMGYTGAKGAAVATSPLAVAVPATGHAPLLLDMATATIAL 193

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   +  G  LP       +G  T +P   E+    LP+G  KGSGMS+  +++ ++L
Sbjct: 194 GKIRQAKADGTPLPEGAAATRDGTPTTDP---ERAVMPLPLGGVKGSGMSLAFELLTSVL 250

Query: 241 SDGASVAEVTQDNSDEYGISQ--IFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
                 +    D+       Q  + IA++             +   +  + +   AD+  
Sbjct: 251 VGAPIFSSFHSDDPQGRTHRQNALLIAVDPAAFGGAEAFTEAVDTTLSTLKALPVADDAS 310

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +  PG     L AE  R GI V   VW ++
Sbjct: 311 GVFYPGERSAALSAERGRTGIPVAPKVWREL 341


>UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobiales
           RepID=Q133C9_RHOPS
          Length = 366

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 77/348 (22%), Positives = 137/348 (39%), Gaps = 22/348 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V  ++L     +V    G     A            +G  SHGV R P +I+    G 
Sbjct: 7   VTVQADRLIDFVAQVFERAGSSKAEARRIGSYLTTANLTGHDSHGVIRVPVYIRWRNAGA 66

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PD        L ++   D +   G     + +   IE     G+  V L+NA H  R 
Sbjct: 67  VHPDQTVDVPVDLPSLAVVDGKFGYGQTVGPQAVRIGIEKCKAQGLSAVGLKNAGHIGRI 126

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMS 176
           G +   AA +G + I +  +    ++ P+G  E R+ T P  V +  P  P  ++D + S
Sbjct: 127 GDWAEMAAAEGLVSIHFVTAAGSILVAPYGGVERRLSTAPYCVGVPRPGAPPVVLDFATS 186

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-------------KNRRILPMGY 223
           + + G + V    G+ LP     + +G  +++P  +                  I   G 
Sbjct: 187 IVAEGKVLVAARGGKALPQGALINPDGTFSEDPATLYGAFEKDGPINHVNGAGAIRAFGE 246

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KGSG++++ +++   LS   +           +      I ++  ++      DA++ R
Sbjct: 247 HKGSGLALICELLGGALSGNGATG-----PDRPFANGMFSIYVDPQRIDPAHVFDAEVTR 301

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            +DY  SA+       + +PG       A+   NG+ + D  WA I A
Sbjct: 302 YVDYFKSAKTVAGVDQVLIPGDPELKTRADRTENGVPLSDDTWAAIVA 349


>UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Verrucomicrobiae
           bacterium DG1235 RepID=B5JGV2_9BACT
          Length = 351

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 71/340 (20%), Positives = 141/340 (41%), Gaps = 14/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   E L +   + L   G+  + A   A++       G  +HG+   P ++  LE+G +
Sbjct: 9   RFMAENLLSFAVKALTRAGLAEDRARVVADVLLDADLMGHSTHGLGLLPLYVGALEDGKM 68

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  +   G+   WD +   G     + ++  +E   +H +  V ++ ++H     
Sbjct: 69  EVAGEPVVLNDRGSTLAWDGRYLPGAWLTCRAIEEGLERLGEHPVVTVTIQKSHHIGSLA 128

Query: 122 SYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           SY  +A +KG + +   +     ++ P+G  +     NP+   IP++    + D SMS  
Sbjct: 129 SYPMRAIKKGAMMLLTCSDPNSELIAPFGGLDAVYSPNPIAAGIPTSGRPVIFDTSMSTT 188

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMG----YWKGSGMSIV 232
           ++G+    +  G +LP     D+EG  T +P V+  E +  ILP+G     +KG  + ++
Sbjct: 189 AWGVANRAKQQGERLPGKWMQDNEGKATDDPKVLDSEPSGTILPIGGADHGYKGFALGLL 248

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   LS      E+ +     +G S     I+ D          ++  +      + 
Sbjct: 249 VEALTCGLSGSGRADELGR-----WGCSTFIQLIDPDAFGGSDAFRREMDYLAKRCHDSR 303

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 A+RLPG     L  E    G+ + + V   +  L
Sbjct: 304 TRPGADAVRLPGERALALREEQVVAGLVLPEVVKEGLLKL 343


>UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangium ochraceum DSM
           14365 RepID=D0LLD6_HALO1
          Length = 355

 Score =  297 bits (760), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 81/336 (24%), Positives = 156/336 (46%), Gaps = 10/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  ++ +    +VL+  G+    A + A     T+  GV +HG+   P ++++LE G   
Sbjct: 8   IDSQKAELFVTQVLVRNGLSESDARSVANGLVETSLRGVDTHGLRLLPLYVKELEGGRSN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
              Q +   +  ++ + DA  ++G +      D+A+E+A   G+G+V++ N+NH+     
Sbjct: 68  ARPQFRFEATRASVVKMDADAALGIMAGFAGADKAVEVARKSGVGVVSVANSNHFGAAAL 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           YG + A +G+IGI  T++ A + P+G +    GT+P+    P        +DM+ S  SY
Sbjct: 128 YGLRIARQGFIGIALTHAAARVAPFGGRTQLFGTDPICFTAPRKDGHPFCLDMATSQISY 187

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             ++ +RL G  L      DD G  T EP  +     + P+G +KG G+S+++ ++  LL
Sbjct: 188 SKVKHHRLRGETLEPGWAVDDHGEPTVEPDSV---SALSPVGGYKGQGLSMMVQVLCALL 244

Query: 241 SDGASVAEVTQ----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +D     E++       S+   IS  F+AI+     +     +++  ++D V  +     
Sbjct: 245 ADMPLDWELSHLDSGGFSEPRKISHFFMAIDFSAFTNVERFLSQMGILVDTVRDSAARAG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                           E  R GI +  + +  + A+
Sbjct: 305 GAVAVAG-DIEERRKEERLRTGIPLSAAEFDSLLAV 339


>UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burkholderiales
           RepID=B3R983_CUPTR
          Length = 340

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 80/336 (23%), Positives = 149/336 (44%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  ++L+      L   G  +  A A A    R   +G+ SHGV+R P ++  L +  +
Sbjct: 3   RIALQELERVAVAGLRRAGASALQARATALALVRADAAGLPSHGVSRVPMYVAHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+P   ++  +    DA+           +  A+  A   G G+ A+ N++H+    
Sbjct: 63  DGHAEPAVQSTRASAVLVDARCGFAFAACDLAIAEAMARARATGAGVAAVTNSHHFGAAA 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
                 A  G +GI   NS A MP WG K    GTNP+      P     ++D+S+S  +
Sbjct: 123 LPLEAVARAGMVGIAMGNSPAAMPAWGGKRPLFGTNPIAAVFPRPGHAPVVIDLSLSEVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T 
Sbjct: 183 RGKIMVAARQGKPIPHGWALDEAGQPTTDAQAALRG-SMLPAGGVKGAMLALLVELLVTS 241

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+    GA       D  +   I Q+F  ++           A+++ ++  +       +
Sbjct: 242 LAGARFGAEADSFFTDAGNRPRIGQLFFVLDPGAFAGSQVYAARVEALLAAML------D 295

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++  R+PG    T  A+   +GI V D++W ++QAL
Sbjct: 296 DEGTRVPGARRDTAQAQAAAHGIEVPDALWRELQAL 331


>UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobiales
           RepID=C6B553_RHILS
          Length = 344

 Score =  295 bits (755), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 88/318 (27%), Positives = 145/318 (45%), Gaps = 7/318 (2%)

Query: 18  SRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIE 77
             G   + A   A +       G  SHG+ R PR ++++E G I P  +  +     A+ 
Sbjct: 18  EHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIEAGVIDPQTKGTQRWRADAVL 77

Query: 78  QWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICW 137
           + +    +G + A   ++R      D GIGLVA+RNANH      Y    A  G++GI  
Sbjct: 78  EVEGASGLGPVVAMAAIERLSPHIPDLGIGLVAVRNANHLGMLAHYVEAIAAMGFVGIAL 137

Query: 138 TNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGMLEVNRLAGRQLPVD 196
           ++S A++ P+G     +GTNP+ +A+P +    ++D++ S+   G +  +   GR +P  
Sbjct: 138 SSSEALVHPFGGTRAMLGTNPIAIAVPTAEEPLVLDLATSLVPMGSIHHHAATGRPIPEG 197

Query: 197 GGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ--DNS 254
              D  GN T +PG   K   I P G  KG G+ I ++++   L+  A   +     D+ 
Sbjct: 198 WARDAAGNPTTDPGRA-KAGAIAPFGDAKGYGLGIAMELLVAALAGSALAPDARGTLDSQ 256

Query: 255 DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAEN 314
                  +FI IE       P   A+L   +D V ++  A   + + +PG       A  
Sbjct: 257 SPCNKGDVFILIEPSL---APGLPARLSTYLDAVRASPPASAGKPVLVPGDRARRRRAAA 313

Query: 315 RRNGITVDDSVWAKIQAL 332
            RNG  +D  +W  + AL
Sbjct: 314 SRNGFEIDQRLWEDLNAL 331


>UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobium sp. NGR234
           RepID=C3MH43_RHISN
          Length = 351

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 87/332 (26%), Positives = 153/332 (46%), Gaps = 7/332 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  + L+A    +L + G  ++ A   AE+       G  SHGV R PR+I+  E G + 
Sbjct: 10  IAKDILEAFSAALLEAGGFRADYARQSAELLVWANLRGADSHGVLRIPRYIEMAELGIVK 69

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+     GA+   D  R  G        DRA+ELAA  GIGL ++   +H    G 
Sbjct: 70  GDAKPELAREFGAVAVIDGDRVPGATGMAMAADRAVELAAKFGIGLCSILRTSHAGAVGF 129

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSMFS 179
           +  + A  G +G+  T S  +M   G+K   + TNP+ +A PS       ++DMS +  +
Sbjct: 130 FTERVARAGMVGVAMTASKPLMIYHGSKAEGVSTNPISIAAPSRNAARPIVLDMSTAAVA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   + AG+ +P D G D  G  T +P ++   + +LPM   KGSG+S++++++ ++
Sbjct: 190 LGKIMAAKDAGKSIPPDWGVDANGVATTDPAIV---KAVLPMAGPKGSGLSLMIEILVSV 246

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           L     ++    D  D  G + + +A+           + ++ R+   +     A     
Sbjct: 247 LGGNPLISAALTDKRD-AGFNGLVLALSPTAFGPRDQLEGEIDRLSHAIKGLPPALATDD 305

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           + LPG     L  +  + GI +      ++  
Sbjct: 306 VLLPGERGFLLAEKRLQEGIPLALGTIGRLAE 337


>UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaproteobacteria
           RepID=A8I2I9_AZOC5
          Length = 350

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 93/333 (27%), Positives = 156/333 (46%), Gaps = 8/333 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E L A    +L + G     A   A++     + GV SHGV R PR+++ +  G I 
Sbjct: 8   LAPEALSAFAAGLLEAGGFRPADAKKSADLLVWANQRGVDSHGVLRIPRYVEMVGLGLIN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+PK +   GA+   DA  + G    +++ D+AIE+A   G G    RN  H    G 
Sbjct: 68  PAAEPKVVNEWGAVALIDAGLAPGASAMEQVTDKAIEIAGRLGGGFCVGRNVTHAGAVGY 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFS 179
           +  + A +G +GI  T S  +M   GA+   + +NPL +A PS       ++DMS +  +
Sbjct: 128 FAHRIAARGLVGIVMTASKPLMAYPGARGEVVSSNPLAIAAPSEVAGEPIVLDMSTAAVA 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R AGR +P   G D  G  T +P  +   + + PM   KG+G+S++++++ +L
Sbjct: 188 LGQVLAARDAGRTIPEGWGIDAAGRPTTDPAAV---QALTPMAGAKGAGLSLMIEVLCSL 244

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           L+    +A      +   G +    AI+             ++ +   +     A+  QA
Sbjct: 245 LAGNPLIAPALS-GAAPAGFNGFVAAIDPGAFGSRERFLGDVRGLAAAIHGLPPAEGTQA 303

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + LPG       AE RR+GI +     +K++ L
Sbjct: 304 VLLPGERGRRT-AETRRSGIPLARGTSSKLKEL 335


>UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TSK9_9PROT
          Length = 338

 Score =  293 bits (751), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 73/340 (21%), Positives = 147/340 (43%), Gaps = 18/340 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +   L     RV ++  VD +TA   AE   R    G+ SHG+ R P + +Q  NG +
Sbjct: 3   QYSPADLTDLIIRVFVNSKVDPQTARVVAEALVRAEADGISSHGIARVPPYAEQAMNGKV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+P    +  A+   D++        +  ++RA E+  + GI  + +++++H+   G
Sbjct: 63  DGFAKPTVTRTAAAVLDVDSRIGFAFPAIRLGLERAAEIVKETGIVAIGIKHSHHFGVAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
            +   AA +G + + ++N+ A + PWG  +   GTNP+  A P     P  ++D+S+S  
Sbjct: 123 HHVEDAANRGLMALAFSNTPAAIAPWGGSKALYGTNPIAFACPRGDGRPPLVIDLSVSTV 182

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMSIVLD 234
           + G + +    G  +P D   D  G+ T +  V      + P+G      KG+ + ++++
Sbjct: 183 ARGKVVLADKTGEAIPDDWALDANGHATTDAKVAL-TGSMAPLGGRTAGAKGAALGLMIE 241

Query: 235 MIATLLSDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++   L+        +   +       I  + + I+ +    G    A+ + +   + + 
Sbjct: 242 LLCGALTGSNFGYQGSSFFEPTGVPPSIGHLILVIDSNAFGGGAGTVARAEEMFAEILNQ 301

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                    RLPG             GI + D++   ++A
Sbjct: 302 P------GTRLPGDSRLAKR-SAAPGGIAIPDALAQDLEA 334


>UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKI2_VARPS
          Length = 350

 Score =  292 bits (748), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 83/335 (24%), Positives = 153/335 (45%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+   L+     +  S+G+ +  A + A+        GV SHGV   P +++++  G 
Sbjct: 4   VSVSVHALRGLTAALFRSQGLTALRAASVADSLVCADLEGVASHGVALVPLYLERISKGS 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P  +   G +    AQ ++G ++A   ++ A   A +HG+ +V++R+A H+   
Sbjct: 64  VDPHAEPLVVEDHGGLVVMSAQNALGQVSAAVAVELAAARAREHGVSVVSVRHAFHFGTA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
             +  Q A  G +G  ++N+  +MP  G  E  +G NP+ +AIP+      +VDM+MS  
Sbjct: 124 SYWARQFAAAGMVGFAFSNTRPLMPAPGGAERVVGNNPMAIAIPARVDEPLVVDMAMSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +    G  +P     D  G  T       +   +LP    KG G+++ +D++  
Sbjct: 184 AMGKIRLAEANGEAIPTGWATDAAGRATTSATEAIQG-MLLPAAGPKGFGLAVAIDLLCG 242

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            LSD   GA+V  +  +    Y  S  FIAI+  +L  G     ++      +  + RA 
Sbjct: 243 ALSDGAVGAAVRPLYGELDKPYDCSHAFIAIDAARLHGGAGIAPQVAGFAQAIRDSRRAP 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             + I  PG       A N  +   +   +  ++ 
Sbjct: 303 GTERIYAPGDLERARRAGNGEH-CPIAGELAQRLN 336


>UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=8
           Tax=Sulfolobaceae RepID=A4YFT2_METS5
          Length = 328

 Score =  292 bits (747), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 77/331 (23%), Positives = 136/331 (41%), Gaps = 22/331 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V+ E+LK+    +L  R V  E ++  A+        G  SHGV R    ++ +E G 
Sbjct: 7   MNVSAEELKSIIVEILNEREV--EGSEVIADHMVEAELRGHSSHGVQRLIPLVKGVELGT 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   +         D + S+G +   +     I+   D    ++A++NA+H    
Sbjct: 65  ISRRLQYDVLKKERGSMWIDGKHSVGIVLWNQ----LIQHEFDEPSSVIAVKNASHIGFL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           G Y  + A +GY+GI + N+   +   G     + T PL + IP  P  ++DM++S  S 
Sbjct: 121 GYYTDKLATRGYVGIMFGNAEPAVVLPGTSRKLLSTTPLSIGIPHAPPIVLDMALSSTSR 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   +  G  +P     D EG  T +P +  +   ILP+G  +G  + +VL+++ + +
Sbjct: 181 GKILEAQRKGEPIPEGWAVDSEGKPTTDPELALRGG-ILPIGGIRGFYLMLVLEILTSFI 239

Query: 241 SDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           S  A    V    +  +     +I I I                   + +    +    +
Sbjct: 240 SGSAMGPNVKGVLNTENPPNKGEILIVINPFYFAS----------YTEQIDEIRKLLGME 289

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
               PG     L A     GI +D  +W+ +
Sbjct: 290 ---FPGEHGLQLKARRLTEGIPIDAQLWSTL 317


>UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinobacillus
           pleuropneumoniae RepID=A3N2M1_ACTP2
          Length = 235

 Score =  291 bits (745), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 178/235 (75%), Positives = 210/235 (89%)

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           +ELA+ +GIG+VALRNANHWMRGGSYGWQAAEKGYIGICWTN++AVMPPWGAKE RIGTN
Sbjct: 1   MELASQNGIGVVALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKEYRIGTN 60

Query: 158 PLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR 217
           PLIVA+P+TPITMVDMS SM+SYGMLEV+RLAGRQ  VD GFDD+GN T++P  +EKNRR
Sbjct: 61  PLIVAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDDGNPTRDPATVEKNRR 120

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTR 277
           ++PMG+WKGSG+SIVLDMIATLLS+G S A VT+D  DEY +SQ+FIAIEVD+LIDG T+
Sbjct: 121 LMPMGFWKGSGLSIVLDMIATLLSNGESTATVTEDKDDEYCVSQVFIAIEVDRLIDGKTK 180

Query: 278 DAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           D KL RIMDYV +AERAD   A+RLPGHEFT +LA+N+ NGI VDD+VWAK+Q+L
Sbjct: 181 DEKLNRIMDYVRTAERADPEVAVRLPGHEFTQILADNKANGIPVDDTVWAKLQSL 235


>UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromonas sp. JS666
           RepID=Q125C6_POLSJ
          Length = 353

 Score =  290 bits (742), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 76/340 (22%), Positives = 148/340 (43%), Gaps = 15/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + T   L    +++L + G+ +  AD  A +   T     ++HGV   P +I QL+NG +
Sbjct: 6   RHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D +P+ +   GA   WD     G     K +  A E  A HG+   A+R ++H     
Sbjct: 66  GTDGEPEVVRDTGATVVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLA 125

Query: 122 SYGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +   QA ++G + I  T+      + P+G ++  +  NP  +  P +    +VD+  S+ 
Sbjct: 126 ALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVLTPNPFAIGYPGSKAPVLVDICASIT 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN---RRILPMG----YWKGSGMSI 231
           +  M      AG Q       D+ G  T +P V+E+      +L +G      KG G+++
Sbjct: 186 TVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKGFGLAL 245

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++ +   L+    +     D  + +G +     ++ +          ++  I D   ++
Sbjct: 246 MVEALTQGLAGHGRI-----DAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRAS 300

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                +  +RLPG + +  +A  ++ GI + D+   K+ A
Sbjct: 301 TPVQPDGLVRLPGDQASGNIARAQQQGIALSDATLDKLAA 340


>UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccus denitrificans
           PD1222 RepID=A1BBM1_PARDP
          Length = 356

 Score =  288 bits (739), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 80/337 (23%), Positives = 141/337 (41%), Gaps = 14/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  +++ A    VL + G+  + A+A A++  R       SHG+ R   ++  L  G 
Sbjct: 23  VTMRLDEIFALVLSVLTANGLSRDQAEAIADIVTRAEADACRSHGLYRVEGYVAGLRAGR 82

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P AQP+      A+ Q D  +      A       I  A ++GI  +A+   +H+   
Sbjct: 83  VNPTAQPRVRRLRPALLQVDGDKGFAPFAANLARPHLIAAARENGIAAMAIARTHHFSAL 142

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
            +      E G +  C+      + P G     +GTNP+    P       + D + S  
Sbjct: 143 WADLEPLVEAGLVAWCFVVGQCSVAPHGGSTPLMGTNPIGFGWPRPDGAPFIFDFATSAA 202

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +E+ RLAG  +P   G D EG LT +P     +  +LP G  KGS +S+++++IA 
Sbjct: 203 ARGDVELKRLAGEPIPAGWGIDAEGRLTLDPAEAL-SGALLPFGGHKGSALSMMVELIAG 261

Query: 239 LLSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L        VA +   +       ++FIA++   L       A  +R      +     
Sbjct: 262 PLIGELTSKQVAALGHRDDGPPPGGELFIALDPASLGGSAP--AVAERFFLDAKAQP--- 316

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +RLP        + +  +G+ V   +  +I+AL
Sbjct: 317 ---GLRLPSERRYVARSRSHASGVGVPSDLLRRIKAL 350


>UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1WRH9_VEREI
          Length = 354

 Score =  288 bits (738), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 66/339 (19%), Positives = 139/339 (41%), Gaps = 14/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +  +L+    ++L   G+    ADA A         G  +HG+     +++++  G +
Sbjct: 6   RFSAAELRQFSTQLLQKAGLPLAPADAVARTLVDGDLLGHDTHGLALLVPYVREVSKGAM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++   A   W+ +R  G     K +D  I  A + G   + + +++H     
Sbjct: 66  TTSGEPDVVSDRPAALVWNGRRLPGPWLVHKGIDALIARARELGTAALVIHHSHHIACLA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +Y  +A E+G++ +  ++  AV  + P+G        NP+   IP++    +VD+S S+ 
Sbjct: 126 AYLLRATEEGFLMVLSSSDPAVQSVAPFGGTRAVFTPNPIAAGIPTSGTPLLVDISASIT 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           + GM      AGRQ   +   D +GN +++P     +    ILP+G      KG G++++
Sbjct: 186 TNGMSNRLHKAGRQFEEEWMLDAQGNPSRDPAVLAADPPGSILPLGGLSAGHKGFGLAVL 245

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   LS          D    +G +      +            ++  I +   S  
Sbjct: 246 IEALTGGLSGFG-----RADPPTGWGATVFMSLYDPAAFGGQAAFRRQMDHIAEACRSNP 300

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                  +R+PG       A+    G+ +  ++   ++ 
Sbjct: 301 PRPGVGQVRMPGDRGMARRAQQLEQGVALHPTIAPMLRE 339


>UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium leguminosarum
           RepID=C6B638_RHILS
          Length = 353

 Score =  288 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 72/332 (21%), Positives = 135/332 (40%), Gaps = 13/332 (3%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L     ++L   G++++ A+  A +       G  +HGV+    +++ LE+G +     
Sbjct: 10  ALTQFAKQILTRAGMEADKAETTAAVLVEGDMIGHETHGVSLLSWYVEALEDGSLAKSGS 69

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
            + +   GA   WD +   G     K +++A E   DHG+   A+RN +H     ++  Q
Sbjct: 70  YEIVNDRGAAFVWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSAFMRQ 129

Query: 127 AAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGML 183
             E+G I     +  A   + P+G  +  +  NP+    P S    ++D+S S+ +  M 
Sbjct: 130 VTERGLIVQLSVSHPAASRVAPYGGTKPLLTPNPMAAGFPTSADPILIDVSASITTTTMT 189

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVI-EKNRRILPMG----YWKGSGMSIVLDMIAT 238
           +    AG++ P    F   G  T +P  + E+   ++P+G      KG G+ ++++++  
Sbjct: 190 QNLAKAGKKFPEAWAFTVAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGLGLIVELLGQ 249

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD-EN 297
            LS            S  +  S     I+           A+   +     S   A   N
Sbjct: 250 GLSGKGRAN----TPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPPAPWNN 305

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             +R+PG             G+ V D+ W K+
Sbjct: 306 GPVRMPGDSAAQKRRSALEEGVPVGDAAWQKL 337


>UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11CF6_MESSB
          Length = 358

 Score =  287 bits (736), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 66/339 (19%), Positives = 137/339 (40%), Gaps = 14/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   E L+A    +    G+ +E A   A +       G  +HG+   P +++ +E G +
Sbjct: 11  RYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGM 70

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D  P+ +  LGA   WD ++  G    ++    A+  A   G+G VA++ ++H    G
Sbjct: 71  TLDGDPEVLNDLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLG 130

Query: 122 SYGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +Y   A   G + +        + + P+G     + +NP+    PS     ++DMS ++ 
Sbjct: 131 AYLEPAVAAGCMVLVTLTDPGHSSVAPFGGVTPVLTSNPIAFGAPSPDRPILIDMSTALM 190

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           + G +   R  G  LP     D +G  + +P     +    ILP+G      KG  + ++
Sbjct: 191 TNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEAGHKGFSIGLI 250

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++++   LS          +  D +  +   + ++            ++  ++D    + 
Sbjct: 251 VELLTGCLSG-----RGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDLCHGSA 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                  + LPG +  +     RR+G+ +   + A +  
Sbjct: 306 LRPGFNHVDLPGAQAFSRREGQRRDGVLLSPGIVAGLAE 344


>UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella petrii DSM 12804
           RepID=A9I6A1_BORPD
          Length = 312

 Score =  287 bits (734), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 75/303 (24%), Positives = 141/303 (46%), Gaps = 17/303 (5%)

Query: 35  RTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMM 94
           +T+  GV SHG+ R P ++ +L +G ++   Q + + S  A  Q    + +G + A +  
Sbjct: 2   QTSLWGVDSHGIARLPHYLNRLAHGSVLARPQVRVVRSGPATAQVHGGQGLGIVVAHRAN 61

Query: 95  DRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRI 154
             A+E+A + G+  V + +++H    G Y   AAE G +G+ +T+S A+  P+G     +
Sbjct: 62  RLAMEIAREAGVAAVGVSDSSHCGAVGLYSRAAAEAGLVGLAFTHSDAIAAPFGGHAPFL 121

Query: 155 GTNPLIVAIPS--TPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI 212
           GTNP+ VA+P    P   +DM+ +   +  +   R  G  LP     DD G    +P V 
Sbjct: 122 GTNPISVAVPRQDGPPACLDMASTAIPWNRVMNARREGHALPEGVALDDTGRDATDPLVA 181

Query: 213 EKNRRILPMG----YWKGSGMSIVLDMIATLLSD---GASVAEVTQDNSDEYGISQIFIA 265
              R + P+G     +KG G++++++++   L+    G  ++ + +       +   FI 
Sbjct: 182 ---RALRPLGGPQQGYKGYGLALMIELLCGPLNGNPFGPHISPMYEQLDKARRLGAFFIV 238

Query: 266 IEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSV 325
           I+  +   GP   A + ++   + +          R+PG           R GI V+  +
Sbjct: 239 IDPARFAGGPLLAAVVAQMAAELAAQPGQP-----RMPGDPEQAAQVSRLRGGIPVEPGL 293

Query: 326 WAK 328
           W +
Sbjct: 294 WQE 296


>UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11B93_MESSB
          Length = 354

 Score =  287 bits (734), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 70/335 (20%), Positives = 132/335 (39%), Gaps = 14/335 (4%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
               LK     +L +  V ++ A+  A++       G  +HG+ + P ++  L  G + P
Sbjct: 8   DANALKDYARNLLKALDVQTDIAEVVADVLVEGDLLGHSTHGLAQLPSYLDNLAKGQMKP 67

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
                 ++   A   WD Q   G    +     A   A   G G V +R ++H     +Y
Sbjct: 68  SGTYSVVSDFPAATTWDGQWLPGPWLTRTACIEAKTRARKFGTGTVVIRRSHHIACLAAY 127

Query: 124 GWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFSY 180
                 +G++ I  ++  AV  + P G     +  NP+ V IP+     ++D+SMS+ + 
Sbjct: 128 LEPLTAEGFVCIIQSSDPAVKAVAPHGGTRPFLTPNPVAVGIPTKGDPILIDVSMSIATV 187

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMG----YWKGSGMSIVLD 234
           GM      +G + P     D +G+ T +P VI+ +    ++ +G      KG G++++++
Sbjct: 188 GMARRLIASGERAPFPWLLDGDGHPTDDPNVIDADPKGSLMLLGGIEAGHKGFGLALMVE 247

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
            +   L           D    +G S     ++ D          ++  I D   S    
Sbjct: 248 ALTGGLGGHG-----RADKPTNWGASVFVQVLDPDAFGGKEALLREMSFIADECVSGPSR 302

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           D N  +R+PG        E    G+ +   +   +
Sbjct: 303 DINNPVRMPGSAGLRRKREALERGVPLHSIIMESL 337


>UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z6D1_9GAMM
          Length = 333

 Score =  287 bits (734), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 77/335 (22%), Positives = 146/335 (43%), Gaps = 14/335 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + +++     L++ G   E A   A   A     G+ + G+     +++ L+ G + 
Sbjct: 4   LSLQAIESLCRESLLAVGASDEQAAIVAAEIAEAEAEGIRNVGLGYIHLYLKHLKVGKVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+AQP  + +  A    DA     +        R IE A + G+ ++A+  ++     G 
Sbjct: 64  PNAQPSVVKTSAASTVVDADFGFCHHAYMVGEQRLIETAREQGVAMLAIHQSSSAGVLGW 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           +  + A++G + + + NS   +   G K    GTNP     P  +    +VDM+ +  + 
Sbjct: 124 FVRRLAQQGLVSLMFANSSKAVAAHGGKVPFFGTNPFAFGAPRGTDEPLVVDMATASTAR 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             L      GR++      D +GN T +P    K    LPMG  KG G+ +++D++A +L
Sbjct: 184 VNLVKAAAEGREIEPGHAIDADGNPTTDPSAGLKG-AQLPMGGPKGFGLGLMVDVLAGVL 242

Query: 241 SDGASVAEVTQD---NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      E +     +     + Q  IAI+ +  +DG      L+ +   +T      EN
Sbjct: 243 TGSNCSYEASMFANIDGGPPNVGQTIIAIDPN-FLDG-NFTTHLETMFAALT------EN 294

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +R+PG     L  ++  +G+ V  S+  +I  L
Sbjct: 295 NDVRIPGERRAQLRVKHEADGVDVPQSLIDQITEL 329


>UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonocardineae
           RepID=A4FEK8_SACEN
          Length = 375

 Score =  286 bits (733), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 89/350 (25%), Positives = 153/350 (43%), Gaps = 18/350 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V +  L +   R+   RGV ++ A   A        +G+ +HG+    R ++   ++G
Sbjct: 15  VRVDYADLLSFTTRLFAERGVPADRAHTAASALCYGDLTGLEAHGLFNLTRLYLPLFDSG 74

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            + P AQP+ +T LGA    D++R++G  +A + MD A + AA HGIGLV +R+A H+  
Sbjct: 75  RVDPAAQPRVLTDLGACAVVDSRRALGLWSAAEAMDSAADRAAQHGIGLVTVRDATHFGC 134

Query: 120 GGSYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSM 175
            G +  +AAE+G IG+   N     +  P G     +GTNPL VA P+ P    ++DMS 
Sbjct: 135 AGFHTARAAERGVIGVLAGNCGGQRIARPPGGTPAMLGTNPLSVAAPALPGHPFVLDMST 194

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL-------PMGYWKGSG 228
           ++   G +      G  +P     D  G    +P   ++    L         G +KG G
Sbjct: 195 TVVPTGRVRTAAARGEPVPPGWLVDSSGAAVTDPAAFDRGEAYLNWLGGDQDTGAYKGFG 254

Query: 229 MSIVLDMIATLLSDGASVAEV------TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
           + +V++++  LL                + +  +  I    IAI    L          +
Sbjct: 255 LGLVVELLGALLPGAGLGPAPEALDGDGRPHGRDDDIGFSAIAIAPRLLRPDRDFAGAAR 314

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + + + +   A  +  +R PG           R G+ V   + A +  L
Sbjct: 315 ALFETINACPPAPGHADVRYPGWWEAERAQSRLREGVPVPAGLHADLVRL 364


>UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacterium radiobacter
           K84 RepID=B9JPX6_AGRRK
          Length = 340

 Score =  286 bits (732), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 80/338 (23%), Positives = 145/338 (42%), Gaps = 15/338 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +E +      +L   G  + +A   A   A   + G  SHG+ R   ++  +++G +
Sbjct: 3   RQPYETVVETLELILTKHGYSARSAGILALNCATAQQDGSESHGLFRIKDYLAIIKSGYV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D  PK +       + DA      +      +R ++ AA++GI +VA+RN++H     
Sbjct: 63  NGDPNPKVVDVAPGFIRVDADNGFAQIALADAKERLVQKAAENGIAIVAIRNSHHLGALY 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFS 179
                 A++G++ +   NSIAV+ P G +    GTNP+  A P    P  + D + S  S
Sbjct: 123 LDVEDLADRGFVSLAVVNSIAVVAPPGGRAGVYGTNPMAFAAPRAEGPPLVFDQASSTMS 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G ++V    GR LP   G D  G  T  P  I     +   G  KG+ ++++++++   
Sbjct: 183 HGDVQVAAREGRLLPEASGIDKRGIPTNSPHAILNGGALSTFGGHKGASIALMVEILCAA 242

Query: 240 LSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDG-PTRDAKLQRIMDYVTSAERAD 295
           L       EV       +      +  I I+     DG P    ++  +++ ++ A    
Sbjct: 243 LVGADFSYEVDWSETPGARSARTGETIILIDPRTGADGLPPLAERVGTLIEALSVA---- 298

Query: 296 ENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
                R+PG     + A +  NG + VD+  W  +  L
Sbjct: 299 --GQKRIPGDR--RIKARSEANGSVPVDEKQWLALLEL 332


>UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B8DQ74_DESVM
          Length = 356

 Score =  285 bits (731), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 77/349 (22%), Positives = 134/349 (38%), Gaps = 29/349 (8%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  + L A    VL   GV    A + A         G+ SHGV R P++  Q+  G 
Sbjct: 3   VILRPDDLAALCRTVLERAGVLPAAASSVAGALVAAECMGIPSHGVARLPQYADQVAAGK 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA P+  T L A  + DA         +  +D A+ LA   G   + + N++H    
Sbjct: 63  VRGDAVPRVETPLPATVRVDAGCGFAYPALEAGLDVAVPLALRMGCAALGVTNSHHCGVA 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI----------------- 163
           G +  +AA +G + + + N+ A M PWG     +GTNPL  A                  
Sbjct: 123 GLHVERAARQGLVALLFANTPAAMAPWGGNRASLGTNPLAFACPAPPEDAPEPTAAAGAG 182

Query: 164 PSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY 223
           P     ++D+S+S  + G +      G+ +P     D  G+ T +         +LP G 
Sbjct: 183 PEHDPLVMDLSLSTVARGKIVAAAREGQPIPAGWAVDAHGSPTTDARAAL-GGMLLPFGG 241

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
            KG+ ++++++++A  L+      E +             Q  + I       G     +
Sbjct: 242 AKGAALALMVELLAASLTGSNHAYEASSFLDAAGGPPRTGQCMLLIAPQAF--GADFSGR 299

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              ++ +V            RLPG           R G+ +  S+   +
Sbjct: 300 AAALLGHVLDQPCT------RLPGARRFERQRRAHREGVAIPWSLHQDM 342


>UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteobacteria
           RepID=Q1GLV8_SILST
          Length = 344

 Score =  285 bits (729), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 77/336 (22%), Positives = 146/336 (43%), Gaps = 14/336 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T  ++++     L++ G     A   A   A T   GV SHG+   P + Q +E G + 
Sbjct: 16  LTLSEIESLAFDALVAAGTSPANARPLAVATAMTEADGVASHGLAYIPIYAQHVECGKVD 75

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK      A+   DA     +       ++ I LA + G+ ++A+ N+ +    G 
Sbjct: 76  GQANPKVAHPRPAVITVDAATGFAHRAIDLGFEQLIPLAKEMGVAVLAVNNSYNCGVLGV 135

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSMFS 179
           +  + A+ G +G  +TN+ A + P G  +  +GTNP  ++ P +      ++D S S  +
Sbjct: 136 HTQRLAQAGLMGFGFTNAPASIAPSGGAKPVVGTNPFSISAPGSDGTAALLIDQSASTIA 195

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
              +  +   G+ +P     D +G  T +P    K   ++P G +KG G+++ ++++A  
Sbjct: 196 KSEVMKHAREGKPVPQGWVLDADGQPTIDPDAGLKG-SMVPSGGYKGVGIALTVELLAAA 254

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++    GA  +  +          Q FIAI+ D    G     KL  ++          +
Sbjct: 255 MTGATLGAVASPFSGTAGGPPKTGQFFIAIDPDA-TSGGLFQEKLADLISAFR------D 307

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG    +        G+ V+ ++  +++AL
Sbjct: 308 QDGARLPGDGRQSARLRAATEGVRVNAALLERVRAL 343


>UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphaproteobacteria
           RepID=Q21D51_RHOPB
          Length = 346

 Score =  284 bits (728), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 146/335 (43%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V  E++++     L++ GV  + AD   ++       G  SHG+ R  R +++++NG 
Sbjct: 1   MIVEAERVRSCAVDALMAAGVLRQDADQQVDLLLEAELRGRPSHGLLRLARIVERIDNGV 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A            + D Q  +G + A   ++     A + G+ +  + NANH    
Sbjct: 61  IDPRASGCHHWKAAGFLEVDGQNGLGPVVALSALEAISLRARETGVAVATIVNANHLGML 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
             Y    A +G   I  + S A++ PWG +   +GTNP+ + +P++P   ++DM+ S+ S
Sbjct: 121 AWYAETIARRGLTIIALSISEALVHPWGGRRAMLGTNPVAIGVPASPRPFVLDMASSLVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +  +   G  +P     D +GN T       K   I P G  KG  + +  +++   
Sbjct: 181 MGQIHDHANRGAPIPGHWALDAQGNATT-DAAAAKAGSIAPFGEAKGYALGLAFEVLVAS 239

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A   +V    D+++      +FI I+             +   ++ + +   AD  
Sbjct: 240 LTGSALGRQVRGTLDSTEVCNKGDVFIVIDGA---SSAAMAQVIGGYLEAIRAEPPADGF 296

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            A+ +PG            +GI++ D VWA +  L
Sbjct: 297 AAVAIPGDRSIAARQRALADGISIADQVWAGLVRL 331


>UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria RepID=Q1GM21_SILST
          Length = 348

 Score =  283 bits (726), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 84/339 (24%), Positives = 145/339 (42%), Gaps = 16/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++T ++++A   RVL   G  S    A +EM  R       SHG+ R       +++G I
Sbjct: 10  QLTLDEVRALAERVLTHCGYASAHVAAISEMLYRCQLDDCQSHGLFRLFMCANTMKDGKI 69

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+  +   AI + DA+  +  L  ++ M   IE A  +G+  +A+ N  H+    
Sbjct: 70  DAAASPQIHSEDTAIIRADAREGMSLLAVQEAMPTLIEKARRYGMAALAVNNCFHFSALW 129

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 +  G  G+    S + + P G  +  +GTNP+  + P         D + S F+
Sbjct: 130 PEVEALSTAGLAGLSMVPSHSWVAPAGGTKGTLGTNPIAFSWPRKGQDPFTFDFATSGFA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +E+ + AG+ LP     D+ G  T +P     N  +L  G  KGS +SI+++++A  
Sbjct: 190 RGEIELYKRAGKPLPEGVAIDERGQPTCDPDAAL-NGAMLTFGGHKGSALSIMIELMAGP 248

Query: 240 LSDGASVAEVTQDNSDEYGI---SQIFIAIEVDKLIDG--PTRDAKLQRIMDYVTSAERA 294
           L D     E               QI +A + +K   G     DA+ +R+   + +    
Sbjct: 249 LIDDLISLESEAAAGRPGCAPYHGQIILAFDPEKFSGGRVAQNDARAERLFADIIA---- 304

Query: 295 DENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
              Q  RLP        A N   G + +  +++  ++AL
Sbjct: 305 ---QGARLPSQRRYAARARNLERGYLEIPSALYRDLEAL 340


>UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2 Tax=Idiomarina
           RepID=Q5QTW6_IDILO
          Length = 356

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 73/340 (21%), Positives = 135/340 (39%), Gaps = 15/340 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++  + +L       L   G   E A   +         G  +HG+ R     Q L +G 
Sbjct: 6   VRFDYSELSDWARTCLTEAGASGEVARNVSYYLLEGDLLGFSTHGLIRLLNNCQWLRDGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            +   QP  +    A+  WDAQ   G     + +D A ++A   G G V +R + H    
Sbjct: 66  SLAKGQPVVLRERAAVANWDAQFLPGPYVVPQAIDAACKMAKQAGTGTVVVRRSQHVAAL 125

Query: 121 GSYGWQAAEKGYIG--ICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSM 177
            +Y   A ++G +   +C T     + P+G KE     NP  V +P S    + D+S SM
Sbjct: 126 AAYLSIATDQGLVVSLMCSTPGQRAVAPFGGKEAVFSPNPFAVGVPSSNNPLLFDISFSM 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMG----YWKGSGMSI 231
            + G +   +  G +LP       +G  T +P    +     I P+G     +KG G+++
Sbjct: 186 TAAGKVRQAKANGTRLPYKALIKPDGEWTDDPLTFFESPGSSIAPLGGEQLGYKGYGLTL 245

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFI-AIEVDKLIDGPTRDAKLQRIMDYVTS 290
             ++ +  LS         +  SD+   + I++  I+ +   +      ++  ++     
Sbjct: 246 FSEIWSMALSQYG-----RRQGSDDGDANSIWVQVIDPEAFGEKQKFLQQVDDLLADSRK 300

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  A   Q +R+PG        E  + G++   +    +Q
Sbjct: 301 SAPAVPEQPVRIPGEGAQKRKREQLQQGVSYSSATLKVLQ 340


>UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionaceae
           RepID=Q5E5E9_VIBF1
          Length = 315

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 72/310 (23%), Positives = 132/310 (42%), Gaps = 16/310 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV++ ++K    R  I+ G+  + A+   ++   + + G  SHG+         + +  
Sbjct: 1   MKVSYYEVKERLIRKFIASGLAWDDANWVTDVLISSEQRGDKSHGIKHAKNIFDVINSEC 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            I  A    I    +I   D Q SIG + AK+ +D AI+ A  +G   ++LR++NH    
Sbjct: 61  YIAQAP--IIHDERSITILDGQNSIGPIVAKQAIDIAIKKAKKYGTAAISLRSSNHLFSL 118

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFS 179
             Y    A    IG   ++S   M    +    IGTNP     P S    ++DMS +  +
Sbjct: 119 SHYVRYIANNNMIGFICSSSSPAMAAPNSLNATIGTNPFAFGAPSSKDPIVIDMSSTNVA 178

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G ++  + A   +PV    D+ GN T       K   + P+G +KG  +  ++D+ +++
Sbjct: 179 RGKIKEYKDAELDIPVSWALDEYGNPTTCAIEALKG-TLSPLGGYKGFALGCMIDIFSSV 237

Query: 240 LSDGASVAEVTQ-----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           LS  A   ++T      + +D          +++ K I       ++   +  +      
Sbjct: 238 LSGSAFSTQITGTSLHMEEADVNKKGDFLFVLDISKFIQLSEFKIRMDEFIHII------ 291

Query: 295 DENQAIRLPG 304
            E+    +PG
Sbjct: 292 -ESNGGYIPG 300


>UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UCA9_SINMW
          Length = 356

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 93/338 (27%), Positives = 146/338 (43%), Gaps = 15/338 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  + L+A     L + G    +A A        +  GV SHGV     + + L  G + 
Sbjct: 7   VAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVLRGGRVN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                    +  A    D   ++G+  A   MD+AIELA + GIG V +  ++H+   G+
Sbjct: 67  GTPNLSVRRTAAATAVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSHFGAAGA 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y   AAE G IG   TNS  V+ P+  +E   GTNPL  A PS      ++DM+ S    
Sbjct: 127 YARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTNPLAFAAPSGGARPWLLDMATSSIPL 186

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY----WKGSGMSIVLDMI 236
             L + +  G  LP     D+ G  T EP    + R +LP+G     +KG+ ++ V  ++
Sbjct: 187 NRLLLCKSLGMSLPAGVAVDEAGQPTTEP---FEGRTLLPLGGVDFSFKGAALAGVATLL 243

Query: 237 ATLLSDGASVAEV-----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           + +L        +     T D S    +    +AI+ D+       D  +   ++ + SA
Sbjct: 244 SAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEALRSA 303

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             A E   +  PG     + A  R+NGI +D    A +
Sbjct: 304 -PAQEGCEVLAPGDREWRVEAARRQNGIPIDPDTAAFL 340


>UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=4
           Tax=Alphaproteobacteria RepID=A8LPS4_DINSH
          Length = 339

 Score =  282 bits (721), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 68/335 (20%), Positives = 136/335 (40%), Gaps = 14/335 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++    +    R   + GV    A + A+        G   HG +R   ++ Q  +G I+
Sbjct: 9   LSLPDARDLLFRAFTANGVPEGAARSTADALVAAEAEGQVGHGFSRLEDYVAQARSGKIV 68

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+             DA         ++ +D  I +A + G   +A+  ++H      
Sbjct: 69  AGAEVTITRPAPTTLLVDAGHGFAYPALERAIDEGIAVARELGTAAIAVTRSHHCGALSI 128

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           +  +AA+ G + +   N+ A + PWG K    GTNP+  A P   +   ++D+S+S  + 
Sbjct: 129 HVERAAKAGLVAMMVVNAPAAIAPWGGKTPLFGTNPIAFATPRAGSAPLVIDLSLSKVAR 188

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   + AG+ +P     D  GN T +         ++P+G  KG+ +++++++++ ++
Sbjct: 189 GKVMNAKKAGKPIPEGWALDAAGNPTTDAEAAL-GGTMVPIGEAKGTALALMVEILSAVM 247

Query: 241 SDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +  A   E       +    G+ Q        +        A+L  ++  + + E A   
Sbjct: 248 TGAALSTEAGSFFSADGPPPGVGQFLTLWRPPE--GAEAFTARLAPLLAQIETMEGA--- 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              RLPG      L   + +GI V  +     + L
Sbjct: 303 ---RLPGTRRLAALNAAQAHGIAVPRAYLDGARRL 334


>UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsis dassonvillei
           subsp. dassonvillei DSM 43111 RepID=C1YJN3_NOCDA
          Length = 377

 Score =  281 bits (719), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 93/348 (26%), Positives = 156/348 (44%), Gaps = 18/348 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V  + L A    V   RG+  + A   A        +G  SHG+    R ++  L+ G
Sbjct: 16  VRVRHDDLVAFAAGVFTDRGLPPDRAAEAARALCHGDLAGPRSHGLANLTRLYLPLLDEG 75

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              P A+P+ +  LGA   WD++R++G   A + MD A E AA HGIGLV++R A H   
Sbjct: 76  RADPAAEPRVLADLGAAVLWDSRRALGLWAASEAMDLAAERAARHGIGLVSVRGATHLGC 135

Query: 120 GGSYGWQAAEKGYIGICWTNS--IAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSM 175
            G +  +AAE+G +G+  +N     +  P G     +GTNPL VA P+   P  ++DMS 
Sbjct: 136 AGYHALRAAERGMVGLVASNCGRQRIARPPGGAVAMLGTNPLSVAAPAGEHPPFLLDMST 195

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR-ILPMGY----WKGSGMS 230
           +    G +      G  LP     DD G    +P   +  R  ++ +G     +KG G+ 
Sbjct: 196 TAAPTGRIRQAAREGLALPEGLLCDDTGAPVTDPAAFDAGRAHLMWLGGEAGRYKGFGLG 255

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEY------GISQIFIAIEVDKLIDGPTRDAKLQRI 284
           +++++++ L+    +       + D         I     AI    L  G   DA+   +
Sbjct: 256 LMVEVLSALVPGAGTGPHPDALDGDGGPSGRDDDIGFFVAAIAPGALRQGADDDAR--EL 313

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + +    D +  +R PG        E R  G+ ++  ++A++  L
Sbjct: 314 FGALLACPPTDPDAPVRYPGWHEYHRARELRLAGVPLEAELYAELAEL 361


>UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Labrenzia
           alexandrii DFL-11 RepID=B9QUQ5_9RHOB
          Length = 349

 Score =  280 bits (718), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 73/336 (21%), Positives = 145/336 (43%), Gaps = 15/336 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +++    +       ++ GV    A + A         G   HG +R   +  Q+++G I
Sbjct: 19  RLSLCNAELLIKSAFLAVGVPDLAAQSVANALVAAEAEGQVGHGFSRVEDYAAQVQSGKI 78

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+        +    DA           ++++  E+A +HG   + +  ++H     
Sbjct: 79  AAAAEVIISHKGISSLLADAGFGFAYPALDAVIEKGSEVALEHGCATMGITRSHHCGALS 138

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
               + A++G + I   N+ A M P+GAK+   GTNP+  A   P     +VD+S+S  +
Sbjct: 139 VQVEKLAKQGLMAIMVANAPAAMAPFGAKDPVFGTNPIAFAAPRPGKDPLVVDLSLSRVA 198

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R AG+ +P     D +GN T       +   +LP+G  KG+ ++++++++A++
Sbjct: 199 RGKVMNARKAGKDIPEGWALDKDGNPTTSAEAALEG-TMLPIGEAKGTALALMVEILASV 257

Query: 240 LSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++  +   E       +    G+ Q  IA++    +D     A++  ++  + + E A  
Sbjct: 258 MTGASKSTEASSFFSADGPPPGVGQFLIAMKP---MDTEHFAARIDTLLSLIETMEGA-- 312

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG      +A+ R  GI V       ++ L
Sbjct: 313 ----RLPGSRRAATIAKARVEGIDVPVRYVDAVRKL 344


>UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus RepID=C1XHL2_MEIRU
          Length = 332

 Score =  280 bits (717), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 66/336 (19%), Positives = 141/336 (41%), Gaps = 18/336 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V +  LK A +      G+  + A+A  E+       G   HG+ R  ++  QL+ G 
Sbjct: 1   MRVPYPVLKQAVSSHFQGLGLAPDHAEAFTEVILEAELEGNLGHGLTRIAQYTAQLQAGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  Q +   +   +    A  + G +     +     +A + G   +A+R A H    
Sbjct: 61  LNPRPQMRLERTKPGVAVLHADGAPGPVAGLFAVQALAPMAREQGSAALAVRGAGHSGVL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
            +Y  + A++G + + + N+   + P       +GTNP+ +  P+ P   ++D S+S+ +
Sbjct: 121 SAYVGRLAQEGLVALAFANTPPAIAP----GPVLGTNPIALGAPAEPQPVIIDTSISVVA 176

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G  +P     D EG  T +     +   +LP+G  KG  ++++++++A  
Sbjct: 177 RGKIIAAAKKGEPIPPGWALDKEGRPTTDAKAALEG-SLLPIGEGKGFALAVLVEILAGA 235

Query: 240 LSDGASVAEVTQDNSDE---YGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+      E+               + +A +      G     ++ ++++ + +A     
Sbjct: 236 LAGDVLSPELPLPWMPPAQAAKPGLLLLAFDPAAFGPG--YRGRVAQLIEALKAAGG--- 290

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               R+PG     L  +    G+ V+ ++ A++  L
Sbjct: 291 ----RIPGARRAALREKALAEGLEVNQTLQAELGTL 322


>UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacter hongkongensis
           HLHK9 RepID=C1D4D2_LARHH
          Length = 348

 Score =  279 bits (715), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 82/338 (24%), Positives = 140/338 (41%), Gaps = 10/338 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+T ++++      L + G  +  A   A         G  SHG+   P ++  +  G 
Sbjct: 1   MKLTADRMRHMAEATLTALGSTAAEARLVAGHLVEANLRGHDSHGIGMLPFYVDSVARGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+  +R  G   A + M  AI       + L+ L  A+H  R 
Sbjct: 61  LHPNQPARLLNDQGAVLQFSGERGYGQRVAVEAMRAAIARVRQTQVVLMTLSAAHHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS----IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDM 173
           G YG  AA  G++ I + N       ++ P+G    R GTNPL +A+P     P  ++D 
Sbjct: 121 GHYGELAARLGFVSIHFVNVIDYDQPLVAPFGGTAPRFGTNPLCIALPGGVREPPFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMGYWKGSGMSI 231
           + SM +YG   V  LAGR+       D  G  T +P  + +     + PM   KGSG+  
Sbjct: 181 ATSMVAYGKTRVAYLAGRRFDTPVMLDAAGQPTADPRAMWESPTGALRPMADHKGSGLVA 240

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             ++    L  G    +     +     +   I I+  +L D      +   +  ++ S+
Sbjct: 241 ACEL-LAGLLSGGGTLQPGNPRAGGILNNMTTILIDPARLADMDWLRQEFDAMAGWIRSS 299

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             A   Q ++L G        E  + G  + ++ W  I
Sbjct: 300 PPATAGQPVQLAGDPERRQRHERLQWGTGMAEAEWQGI 337


>UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKP7_VARPS
          Length = 355

 Score =  278 bits (712), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 66/335 (19%), Positives = 130/335 (38%), Gaps = 14/335 (4%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPD 64
            E LK     +L   G+ +   D+ A         G  +HG+     ++++LE+G +  +
Sbjct: 11  AEALKDYAGALLQKAGLAAPMTDSVARTLVEGDLLGHDTHGLALLAGYVKELESGGMTRE 70

Query: 65  AQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
             P+ ++   A   WD +R  G     + MD  +  A + G   + +R ++H      Y 
Sbjct: 71  GAPEVLSDRPAAVLWDGKRLPGPWLMDQGMDLLVPRARELGTASLVIRRSHHIACLAVYM 130

Query: 125 WQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYG 181
            +A E+  + +   +    A + P+G  +     NPL +  P S    MVD+S S+ + G
Sbjct: 131 LRALEEDMLMLLACSDPNTASVAPFGGTQAVFTPNPLAMGFPLSQGGVMVDISASITTNG 190

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMG----YWKGSGMSIVLDM 235
           M    R AG     +   D  G  +  P V+       +LP+G      KG GM+++++ 
Sbjct: 191 MSNRKRAAGETFAEEWLIDAAGKPSNNPQVLFDQPPGTLLPVGGLSHGHKGYGMALLVET 250

Query: 236 IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +   L+            +  +         ++           ++  +     +    D
Sbjct: 251 LTAGLAGHGRADPPEGWGATVHVTLH-----DLHAFGGKEAFLRQMDHVAAQCRNNRPID 305

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             + +R+PG           +NG+ +  S+   +Q
Sbjct: 306 PARPVRMPGEGGLKRRDAQSKNGVRLHPSIARSLQ 340


>UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C5312
          Length = 350

 Score =  277 bits (709), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 81/336 (24%), Positives = 126/336 (37%), Gaps = 11/336 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            +   L      +  + GV +  A   A         G  SHGV R P+++  +  G   
Sbjct: 4   FSPAALTQLSQTLFEAVGVPTTDAATVARSLVDANLCGHDSHGVMRVPQYLDFIRKGTYK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A    ++   A+   DA   +G +   +++D+ +  A   GI    LRN  H  R G 
Sbjct: 64  AGAPLTVLSETPAVVAADAGWGLGQVQTYRLLDKLVPKAKALGIAAGTLRNCGHTGRLGE 123

Query: 123 YGWQAAEKGYIGICWTNSIAV---MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           Y    A++ +      NS      + P G  E RI TNP+ +  P ST   ++D   S  
Sbjct: 124 YAEFVAKENFALFAAVNSHGSGRRVAPPGGTEGRISTNPICMGTPTSTDPVVIDFGTSSV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGY---WKGSGMSIVL 233
           + G +                D  G  T +P V+  E    +LP G    +KG G+ ++L
Sbjct: 184 AEGKVRAQFQKKEPAGEGWLIDHTGQPTTDPSVLYNEPRGALLPFGGTQAYKGFGLGLLL 243

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           D++   LS GA             G + +F+               +   +  YV S   
Sbjct: 244 DLLCGGLSGGACSNPTFPLAGQ--GNAAVFVLFNPALFGGVEHFLKETDGLTAYVRSCPT 301

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           A     I LPG    T   +  ++GI V D  W  I
Sbjct: 302 AAGAGTITLPGDPERTAKGKRTKDGIPVPDGTWELI 337


>UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=B6A4N6_RHILW
          Length = 344

 Score =  276 bits (708), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 67/338 (19%), Positives = 132/338 (39%), Gaps = 16/338 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T   L      +    G+++  A A A +          SHG+ R    ++ +++G + 
Sbjct: 6   LTIADLHGRVEAIFRKAGLNAVQAGALARVIVAGERDACKSHGIYRIEGALRTVKSGKVK 65

Query: 63  PDAQPKR-ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           PDA P+  +    AI + +A     N   +  +    E     GI  + + +  H+    
Sbjct: 66  PDAVPELDLNEGSAIVKVNADGGFANAAFELGVPALAERTRKLGIAALVINDCTHFSALW 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
                  ++G  G+    S A + P G  +  +GTNP     P       + D + S+ +
Sbjct: 126 PEVEAVTKEGLAGLVMCPSYATVAPAGGNKPLLGTNPFAFGWPRKDTSPYVFDFATSVAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +E++R AG+QLP     D +G+ T +P        +LP G  KGS +  +++++A +
Sbjct: 186 RGEIELHRRAGKQLPEGWAIDADGHPTTDPEAALAG-AMLPFGGHKGSAIGTMIELLAGI 244

Query: 240 LSDGASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSAERA 294
           +    +  EV              ++ IA+       G   D  A+ + + + +  +   
Sbjct: 245 MIGDLTSPEVLDYLGTTTLAPFHGELIIAMSPQAFAAGRPGDPFARAELLFEAIVGS--- 301

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 RLP         ++   G+ +  +    +  L
Sbjct: 302 ----GARLPSQRRFAAREKSETEGVVLTAAELELLDRL 335


>UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae bacterium KLH11
           RepID=B9NW20_9RHOB
          Length = 337

 Score =  275 bits (705), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 78/331 (23%), Positives = 140/331 (42%), Gaps = 12/331 (3%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           +++   N VL+  G+D+ ++   A++   +   G  SHG+   P + Q L +G   P A 
Sbjct: 13  EVRELANSVLVKAGLDAHSSAIIADLVWMSERDGPRSHGLRLLPVYAQYLSSGYANPAAS 72

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P    +   + + D       + A    D  I +A ++GI      N +H          
Sbjct: 73  PVIGRAAPGVLRGDGDNGFYQVAALAARDDLIAMARENGIAAFTCANCHHLGALRFDTGP 132

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFSYGMLE 184
            AE G + +   NS++++ P G      GTNP+  A   P     + D + SM +   ++
Sbjct: 133 LAEAGLVAMGVVNSLSMVVPQGGVRPTFGTNPMSFACPRPGAEPVVWDQASSMVALMDIK 192

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           +    G  LP   G D EG  T +P  I + R +LP G  KG+ ++ +++++   L+ G 
Sbjct: 193 MAAAEGHDLPRPAGLDPEGQPTTDPNAILETRGLLPFGEHKGAAIAFLVEVLGAALAGGT 252

Query: 245 -SVAEVTQDNSDEYGI--SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
            SV   +++      I      IAI+  +  +    D  +QRI   +      + N   R
Sbjct: 253 LSVDNASREAHGALNIKGGATLIAIDPARFGN-AAFDQYVQRICAEI------EGNGTAR 305

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +PG       A     G+ V   +  +++ L
Sbjct: 306 VPGDGRLKNRALAEARGVLVSAELLTQLREL 336


>UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Tax=Bacteria
           RepID=Q168E2_ROSDO
          Length = 331

 Score =  273 bits (700), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 70/335 (20%), Positives = 136/335 (40%), Gaps = 22/335 (6%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           + E ++A   + L++ G     A   A         G    G+     +  QLE G +  
Sbjct: 5   SLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDG 64

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            A P       A    +A          + +  A++ A   G   +A+ +A+     G +
Sbjct: 65  HAVPDVTNPRPAAIHVNANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYF 124

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM---VDMSMSMFSY 180
             Q A+ G IGI +TN+  ++   G K   IGTNP+  ++P     +    D S +  + 
Sbjct: 125 TEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIAFSVPDGAGGVAMQFDQSTTTVAL 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + +  G+Q+P+    D +G  T +P    +   ++ +G  KG G  ++ +++A  +
Sbjct: 185 GKITMAKALGQQIPLGWALDAQGKPTTDPQAALEG-SLVSVGGHKGWGFGLMAEILAAGM 243

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      SV  +       + + Q +I I+      G     +L  +      ++ A ++
Sbjct: 244 TGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQ---SGEAFAERLAAL------SQAATKD 294

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  R+PG     +        + V D VW ++Q L
Sbjct: 295 EGARMPGQSRQIMQE------VEVVDQVWNRLQEL 323


>UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaproteobacteria
           RepID=A6UGA2_SINMW
          Length = 345

 Score =  273 bits (699), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 74/334 (22%), Positives = 132/334 (39%), Gaps = 16/334 (4%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L      +    G++   A A A +          SHG+ R    ++ ++ G + PDA 
Sbjct: 11  ALHERVEAIFRKGGLNVVQAGALARVIVAGERDACKSHGIYRIEGALRTVKAGKVKPDAI 70

Query: 67  PKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           P+ I     AI + +A     N   +  +    E A   GI  +A+ +  H+        
Sbjct: 71  PEIIAQEASAIVKVNAGGGFANPAFELGLPVLAERARTQGIAALAINDCTHFSALWPEAE 130

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGML 183
               +G  G+    S A + P G  +  +GTNP     P    P  + D + S+ + G +
Sbjct: 131 ALTGEGLAGLVMCPSYATVAPTGGNKPLLGTNPFAFGWPRAGRPPYVFDFATSVAARGEI 190

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
           E++R AG+ LP     D +GN T +P        +LP G  KGS +  +++++A ++   
Sbjct: 191 ELHRRAGKALPDGWAIDAKGNPTTDPEAALAG-AMLPFGGHKGSAIGTMIELLAGIMIGD 249

Query: 244 ASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSAERADENQ 298
            +  EV              ++ IA   +    G   D  A+ + + + +         Q
Sbjct: 250 LTSPEVLDYLGTTTLAPFHGELIIAFSPEAFAAGRPGDPFARAEMLFEAIV-------GQ 302

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             RLP        A++   GIT+  +   ++  L
Sbjct: 303 GARLPSQRRFAARAKSEAEGITLTAAEVEQLDRL 336


>UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0RXU9_RHOSR
          Length = 349

 Score =  273 bits (698), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 70/295 (23%), Positives = 128/295 (43%), Gaps = 15/295 (5%)

Query: 22  DSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDA 81
           D   A   AE   +    G+ SHG+ R P ++++++ G   P+A    ++  G +   D 
Sbjct: 22  DRTRAATTAECIVQADLWGIGSHGLLRLPYYLERMQAGGYPPEADLVTVSDTGPVVALDG 81

Query: 82  QRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSI 141
              +G+    +  + A E  A +G+  V++ N+ H    G Y   A + GYI + ++N  
Sbjct: 82  GGGLGHWQLWRAAELAAERCATYGVAAVSVGNSGHCGALGIYTRAAIDTGYIALTFSNGP 141

Query: 142 AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFD 200
           AVMPPWG  +  + T+P+   IPS P   ++D++ S  + G +  +   G QLP     D
Sbjct: 142 AVMPPWGGNKPLLSTSPIAAGIPSRPTPAIIDLATSAVARGKIAAHAQNGDQLPDGWALD 201

Query: 201 DEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVT-----QDNSD 255
             G  T +P    +   + P+G  KG  ++ +++ +A          +V       D   
Sbjct: 202 AHGEPTTDPQAALRG-MLSPLGGAKGFALAFLVEALAGGAVGPHLSVDVPDMFDDSDAKH 260

Query: 256 EYGISQIFIAIEVDKLI-DGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTT 309
              I  + + ++  +L   G     ++ R+ + V            RLPG   + 
Sbjct: 261 PQRIGHLIVTVDPARLGSSGNGAQERIDRLANLV-------GEHGGRLPGARRSA 308


>UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11D61_MESSB
          Length = 360

 Score =  270 bits (690), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 66/333 (19%), Positives = 129/333 (38%), Gaps = 13/333 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T E  +    R L+  G   E A             G    G+NR    I +    +
Sbjct: 21  VRLTVEGARDLTRRALVGAGYSVEEAKIIQSQLVTNALDGYGPAGLNRALAIIMEPRARE 80

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             P    + +         D   ++G L   +  + A+E A   G  +V + N     R 
Sbjct: 81  --PRRAIRIVHETPNSALLDGGNNVGYLACWRASEVALEKARATGFAVVGVNNCPFSGRN 138

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
             Y    A  G++ +  T+ +  + P G ++  +GTNP+  A P       +VDMS    
Sbjct: 139 AHYVEPLARAGFVALHTTSGMPHVLPLGGRKAVMGTNPICFAFPTKGRDPIIVDMSTLAI 198

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            +G + ++   G  LP   GFD +GN T +     K   + P G  KG  +S+V+ ++  
Sbjct: 199 MWGDVLLHARTGEPLPEGVGFDSDGNPTTDASKAAKGG-VAPFGGHKGYALSLVVQIL-G 256

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++       ++ D +       +FI ++    +     +  L   +  + S  R +   
Sbjct: 257 LMAGAHLPRGLSSDYAG------LFIVVDPKLTLPAGAFEEHLDLFIRDLKSTPRREGVN 310

Query: 299 AIRLPGHEFTT-LLAENRRNGITVDDSVWAKIQ 330
            I +P          +   + + +D ++ + ++
Sbjct: 311 DILVPSERAFRQRRIQQEADVVDIDVALHSALE 343


>UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YHD0_MOBAS
          Length = 348

 Score =  270 bits (690), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 70/338 (20%), Positives = 141/338 (41%), Gaps = 14/338 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +  L    +  L + G+D+  A+  AE        G  +HG+   PR++++LE G +
Sbjct: 4   RYDYRALIGYAHDALAASGLDAGHAEIVAETLVEGDLLGHSTHGLALLPRYLRELEAGHM 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  +   GA   W      G +  ++ +    + A D G+  VA+  ++H     
Sbjct: 64  TKAGEPTIVRDHGASAAWGGNYLPGPVLVRRALALCTDRARDAGVATVAIGQSHHVACLA 123

Query: 122 SYGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           +Y     ++G   I  ++S A   + P+GA E     NP+    P      +VD+S S+ 
Sbjct: 124 AYLKAVTDEGMAAIIASSSPATASVAPFGAVEGIYSPNPIAAGWPTGGDPVLVDISASIT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           +  ++      GR+LP       +G  + +P          +LP+G      KG  + ++
Sbjct: 184 TNSLVSERVEEGRRLPGAWMIGPDGTASDDPALLTARPAGALLPLGGTEYGHKGFALGLI 243

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++M+   L+          D  D++G S   + ++ +        + +   +      A+
Sbjct: 244 VEMLTAGLAGHG-----RADAPDQWGASVFVMVVDPEHHGGRAAFERQTGFMAGAARGAK 298

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             D   A+RLPG     L  +   +G+ + D + A+++
Sbjct: 299 VPDGASAVRLPGERALRLRRQQMADGVVLSDELLARLR 336


>UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemophilus influenzae
           22.1-21 RepID=A4MVY7_HAEIN
          Length = 234

 Score =  269 bits (688), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 156/215 (72%), Positives = 189/215 (87%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V++++LK  F RVL+ R +  E A+ CA  F  TT++G YSHG+NRFPRFIQQLE GD
Sbjct: 1   MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I+P+A P ++ SLG+IEQWDA ++IGNLTAKKMMDRAIELA+ HG+G++ALRNANHWMRG
Sbjct: 61  IVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTN++AVMPPWGAKECRIGTNPLI+A+P+TPITMVDMS SM+SY
Sbjct: 121 GSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           GMLEV+RLAGRQ  VD GFDDEGNLT++P ++EK 
Sbjct: 181 GMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKT 215


>UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1SWJ6_PSYIN
          Length = 339

 Score =  266 bits (680), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 77/337 (22%), Positives = 143/337 (42%), Gaps = 15/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T E++       L+S+G + E A A A         G  SHG+ R P +I  L++  
Sbjct: 6   INLTLEEIYDLAKTALLSQGANEENAAAIANTVTIAERDGAISHGLFRIPGYIVGLQSKK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++  A P+       I + DA+     LT +  +   I+ A   G+  VA++N++H+   
Sbjct: 66  VVGTATPEIEEVTPIIFRCDAKNGYAPLTHEHCLPPLIDAAKKFGLAAVAIQNSHHFAAL 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
                + +E G IG+   + +  + P G K    GTNP+  + P       ++DM+ S  
Sbjct: 126 WPEVEKMSEAGLIGLTTVSYLPWVAPAGGKTPIFGTNPMAFSWPRAGKNPVVIDMATSSM 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +    G ++P+  G  + G LT +   I K   +LP G  KGS +++++++++ 
Sbjct: 186 AMGEVMIAARDGYEVPLGTGLSESGELTTDAAEIVKG-VLLPFGGHKGSALALMVELLSG 244

Query: 239 LLSDGASVAEVTQDN---SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L       E  + +          Q  +AI  D L  G     +  R  +      + D
Sbjct: 245 PLVGETFSYETQERDKAEEGPARGGQFILAISPDIL-SGKNTSEQTDRFFE------KYD 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  R PG         +     +V+  +   I+ L
Sbjct: 298 AIEGARTPGARRHKNRENSGPR--SVNADLVKTIEQL 332


>UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=1 Tax=Brucella ovis
           ATCC 25840 RepID=A5VTX8_BRUO2
          Length = 319

 Score =  265 bits (679), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 76/339 (22%), Positives = 134/339 (39%), Gaps = 42/339 (12%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +T E+L A    +    G+++  A A A +          SHG+ R    ++ ++ G +
Sbjct: 6   NLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKV 65

Query: 62  IPDAQPKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            PDA P+ +     AI + DA+    N   +  +    E A  HG+              
Sbjct: 66  KPDAVPELVAQEASAIVRVDAKGGFANPAFELGVPVLAERARSHGLA------------- 112

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
                        G+    S A + P G  +  +GTNP     P    P  + D + S+ 
Sbjct: 113 -------------GLVMCLSYATVAPTGGSKPLLGTNPFAFGWPRRDNPPYVFDFATSVA 159

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +E++R AG+QLP     D +G  T +P    +   +LP G  KGS +S +++++A 
Sbjct: 160 ARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEG-AMLPFGGHKGSAISTMIELLAG 218

Query: 239 LLSDGASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRD--AKLQRIMDYVTSAER 293
           ++    +  EV              ++ IA   +    G   D  A+ +   + +     
Sbjct: 219 IMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIV---- 274

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               Q  RLP     T  A ++  GIT++ +    +  L
Sbjct: 275 ---GQGARLPSQRRFTARAASQSEGITLNKAEIDYLDQL 310


>UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella
           bronchiseptica RepID=Q7WEF1_BORBR
          Length = 356

 Score =  263 bits (674), Expect = 5e-69,   Method: Composition-based stats.
 Identities = 70/338 (20%), Positives = 134/338 (39%), Gaps = 15/338 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  +  +    R+    G++   A A A    R    G  SHG+     ++  L +G 
Sbjct: 8   LHIDCDSAQHFTARLFERNGLEPAKAAAVARSLVRADMMGHDSHGLALASWYLDALADGQ 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +     P+ I   GA   W+ QR  G    ++ M+  +E    HG     + N+ H    
Sbjct: 68  MASQGAPEVIADRGACFAWNGQRLPGAWLIERAMEAGVERVRTHGSATCTIANSFHAGAL 127

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSM 177
            +Y  Q   +G + I   +  A   + P+G  E     NPL   IP++    ++D+S S+
Sbjct: 128 AAYLEQLTAQGLLAILTCSGPASRAVAPFGGTEALFSPNPLAAGIPTSQAPMLMDISCSI 187

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG----YWKGSGMSIV 232
            +          GR  P       EG  T +P  V++    +LP+G      KG  M+++
Sbjct: 188 TTTNRTRQLARQGRAFPAAWALTREGEPTDDPRQVVDHGGSLLPVGGVDHGHKGYAMALM 247

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAI-EVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++ +   LS         ++ +    ++ I++ I + +          +   +    T+ 
Sbjct: 248 VEALTQGLSGYG------RNAAPTGIVTNIYLHILDPEAFGGRAAFLRETDWMAASCTAN 301

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
                  A+R+PG +    LA  R  G+ +   + A++
Sbjct: 302 PPRPGVSAVRVPGQQAQARLAAARAQGLRIAAGLAAEL 339


>UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholderiales
           RepID=Q46QD8_RALEJ
          Length = 352

 Score =  262 bits (671), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 76/337 (22%), Positives = 131/337 (38%), Gaps = 12/337 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   + L+   + V  S GV  E A   A    R+   G  +HG+ R P ++ +L  GD 
Sbjct: 4   RWNVQGLEQWTSAVFESCGVAPEHAVEAAAALVRSELRGYKTHGMTRVPSYVDRLRAGDF 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A        G I   DA  ++G +     +   +E        LVA+++  H    G
Sbjct: 64  NPRATMSHRAFAGGI-VLDADGAMGQVAGPHAVRLGLEALESSASVLVAVQSCGHLGALG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
            +   AAE G   +    +  V+   G     IG NP+      P     + D++ S+ +
Sbjct: 123 IHALLAAEAGAFCMVGQRTPPVLGMEGFSGPAIGHNPIAFGCPLPGQAPIVFDVACSVAA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + +    G+ +P     D +G  T +         +LP G  KG G++++++ +A  
Sbjct: 183 RGHILLAAREGKPIPEGWALDADGQPTTDAQRALAG-SLLPTGGHKGIGIAMMVECLAGA 241

Query: 240 LSDGASVAEVTQDNSDEYGI----SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           L+  A      +++    G           ++ +               M   T    A 
Sbjct: 242 LAATADSLSPERNHVGSGGAVGRQGGFVWLVKPEAFSGQGVF----ADYMAQWTGNYLAA 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                RLPGH   TL  E R +GI + D++  ++ AL
Sbjct: 298 GGGDARLPGHRGDTLEREGRAHGIALPDAIARELGAL 334


>UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella petrii
           DSM 12804 RepID=A9I3U5_BORPD
          Length = 351

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 70/334 (20%), Positives = 139/334 (41%), Gaps = 16/334 (4%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L       L++  VD+  A   A         G  +HG+   PR+++++  G      
Sbjct: 9   EALVQFAQHCLLAVDVDAPIAAVVARRVVDADLYGHATHGLALLPRYLKEISEGATQRRG 68

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           + +RI+  GA   WDA    G+    + +  A++     G+  +A+R++ H      Y  
Sbjct: 69  EIRRISEKGACLLWDAAMLPGHWVLHQAIQAALQRVPAQGMVSIAVRHSQHIGALQVYLP 128

Query: 126 QAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGM 182
              + GY+ + W     V  + P+G  +  + + P+   IP+     ++D + S+ S   
Sbjct: 129 DLTDAGYLCLLWATDTKVRSVAPFGGLDPVLTSEPIAAGIPTRGTPILIDTTTSLTSNSF 188

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMG----YWKGSGMSIVLDMI 236
           ++  +  G +LP       +G +T +PG +       ILP+G     +KG  M++++  +
Sbjct: 189 VKQVQARGERLPWPALLSADGRVTDDPGALATDPPGTILPLGGMDHGYKGYAMAMLVGAM 248

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +  LS    +       S E     +   I+ D          ++Q + D   +A   D 
Sbjct: 249 SLGLSGLGRL-------SGEKAQGFLLQVIDPDAFAGRDIFLDEMQALADATRAARPIDP 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
            + +R+PG          RR+G+ +   + A ++
Sbjct: 302 ARPVRVPGDAALARAERQRRHGVRLGADISAALE 335


>UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=Paracoccus
           pantotrophus RepID=Q3S8E9_PARPN
          Length = 359

 Score =  259 bits (662), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 72/334 (21%), Positives = 119/334 (35%), Gaps = 15/334 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE--NG 59
           K+  ++ +    RV+ + G  +  A A A+        GV   G++R            G
Sbjct: 32  KIAIDEARVLVERVMEATGYGAPEAAAIADHLLDCELRGVAMGGLSRAISVADHFAQHRG 91

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            I      +           +    +G L   K  + AIE A   GIG+V    A     
Sbjct: 92  RID---TLRIQRETPFSAALEGGNRVGYLLGAKATEIAIEKARASGIGMVTGHCAIFSGM 148

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMF 178
              Y  +    G++ +  ++   ++ P G  E   GTNP+    PS    ++ D+  S  
Sbjct: 149 LSYYVERITAAGFVAVATSSVGPMVAPEGGTEALFGTNPIAFGFPSASEPVIWDIGTSRI 208

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
                 +    G+ LP D  FD  G  T++P            G  KGSG+++V+ +   
Sbjct: 209 MLAETILAARLGQALPEDVAFDKSGQPTRDPHAALAG-AFRVWGGHKGSGLALVVQLF-G 266

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++    V E          I     AI+     D      K+    D + +    +   
Sbjct: 267 LMAGTPVVQETYGS------IGLFLQAIDPALFGDPEDFATKVAEFSDLLRANRPVEGGP 320

Query: 299 AIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQA 331
           A+RLP         E    G I V + V  ++ A
Sbjct: 321 ALRLPFERSRQRRKEQLARGYIEVAEEVLRQLHA 354


>UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaproteobacteria
           RepID=Q1QWQ4_CHRSD
          Length = 355

 Score =  256 bits (656), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 67/334 (20%), Positives = 128/334 (38%), Gaps = 15/334 (4%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           L      +    G  +E A+  A +       G ++HGV     ++  L+ G+   D + 
Sbjct: 9   LTDLLTALFAEAGATAEVAETTASILVEGDLLGHHTHGVKLAKGYLNDLKAGNACGDHRQ 68

Query: 68  KRITSL-GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
             +T         D    +G     + +  A + A   GIG+V L+ ++H     +Y   
Sbjct: 69  LALTESSPVAAMIDGHYVLGPYLVTRALAHARQAADGFGIGIVTLKRSHHIACLAAYLRP 128

Query: 127 AAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGML 183
             E+G + I  ++  AV  + P+G        +PL + IP      ++D+SMS  + G +
Sbjct: 129 LVEQGLVPIVLSSDPAVASVAPYGGTTPVYTPDPLAIGIPGREHPLLIDVSMSSITNGTV 188

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGY----WKGSGMSIVLDMIA 237
              R  G +L       + G ++ +P          ILP+G      KG  + ++++ + 
Sbjct: 189 NKTRAEGGKLAHPAILTNRGTVSDDPEDFFTTPPGSILPLGGQAFGHKGFALGLMVEALT 248

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           + L          +D   ++G S   + I+  +         +   +      +ER D  
Sbjct: 249 SALGGFG-----RKDAPTQWGASATVMVIDPARFGGTQAFLDETDFLARQCLDSERVDPE 303

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             +RLPG           R+GI +   V   ++ 
Sbjct: 304 VPVRLPGQSGLAKRQRYLRDGIPLPGDVVDALRE 337


>UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98CD3_RHILO
          Length = 333

 Score =  252 bits (645), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 67/335 (20%), Positives = 137/335 (40%), Gaps = 13/335 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ +Q +       +  G + E A +           G+ + G++ F  +++ LE G 
Sbjct: 1   MQLSLDQARGLCRMAALGAGANEEAAQSLTASIIAAEAEGLSTVGLSHFIDYLEALEAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P       A+   DA+  + +    + +D   + A   G+ + + +NA      
Sbjct: 61  IDGNADPVITRPALAVYLSDARGGLAHTGFDRTIDDLAKAAKLFGVAIFSQKNAYTCGAL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G +  + A +G +    TN  AV+   G+ +    TNP+  A P+      ++D S S  
Sbjct: 121 GYFTGRLAAQGLVSFAATNGPAVLAGSGSVKPVYCTNPMSFAAPAADGAPLVIDQSSSAT 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++  +      G+++P     D  GN T +P    K   +L  G  +G+ ++++++++A 
Sbjct: 181 AFVNIRKAAEDGKKIPEGWALDASGNPTTDPAAAMKG-AMLAFGGQRGANIALMVEVLAA 239

Query: 239 LLSDGASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            +S       A       D  G     +AIE   L   P  + +++  +D +        
Sbjct: 240 GISGANWSLDAPWFTGGPDSPGTGLFVLAIEPKLLD--PDFEQRMKDQLDRLRR------ 291

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              + +PG        + +  GIT   +V  +I  
Sbjct: 292 RFGVHVPGRARAEAAEKAQARGITAPKAVVQRISE 326


>UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=1 Tax=Ruegeria
           pomeroyi RepID=Q5LT11_SILPO
          Length = 350

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 75/339 (22%), Positives = 140/339 (41%), Gaps = 21/339 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++   +++   + +  +   D + A+  A      + SGV SHGV R   +  Q+E+G +
Sbjct: 16  RLPAAKVQTRLSAIFQALRFDPDIAEEVAAHLVDASLSGVESHGVMRVLEYAAQVESGYL 75

Query: 62  IPDAQPKRITS-LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            P  +P+ +    G   + +A   IG    +   D   + A   G+  +++R+  H  R 
Sbjct: 76  TPSGRPQVLRDDTGGPTRIEAGGGIGIPALRLAYDTCCDEARARGLSALSIRHVGHTGRH 135

Query: 121 GSYGWQAAEKGYIGICWT----NSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMS 174
           G++   AAE G + IC       +   + P G     + TNP  + IP       ++D +
Sbjct: 136 GAFAEAAAEAGCLTICLGGGNRQTWRQVAPHGGARAMLPTNPWCIGIPGGDRGPVVLDFA 195

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLD 234
            S  + G +   R AG  LP     D  G+ T+ P        ILP G  KG G++++ +
Sbjct: 196 TSKIAGGWIYAARSAGALLPEGCVIDAAGHPTRNPEDYFAGGAILPAGGHKGFGLALLGE 255

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           ++   L                   + + IA+  ++  + P   A  + ++D +     A
Sbjct: 256 LVGEALLG-----------PSTTECNWLLIALSAERFREAPAMAAAAEEVLDELRRCPPA 304

Query: 295 DENQAIRLPGHEFTTLLAENRRNGI-TVDDSVWAKIQAL 332
             +  + +PG       A +   GI +V    W +I+ L
Sbjct: 305 PGSSGVEIPGERERAHRAAS--GGIVSVPRDTWTQIERL 341


>UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lipophiloflavum DSM
           44291 RepID=C0XQZ5_9CORY
          Length = 312

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 73/329 (22%), Positives = 136/329 (41%), Gaps = 18/329 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  + ++  F   L + G+  E A++ A +F     +G  SHG      ++  L+N  
Sbjct: 1   MKLGIDTVRTTFFDALRAHGMSEEQAESSAGVFLDAELAGKPSHGAFHLLTYLSALDNRS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I   A P   T+ G++   DA   +     +K  D+ +++A  +G+ + A+R        
Sbjct: 61  INGQANPTA-TARGSVLAIDADDGLAQFALEKHRDQLLDIARTNGVAVAAVRKTFTTGEL 119

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           G Y    A  G I +  TNS A++    + E  +GTNP+   IP     +VD + +  ++
Sbjct: 120 GWYARFFARHGLISLTTTNSPALVTLNASGERVVGTNPVTFGIP--EAMVVDQAATPAAF 177

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +  +   G  LP     D  G  T +  V      +LP G  +G  +++V +M+A +L
Sbjct: 178 MRVRQHAERGEPLPQGWAVDAAGRPTDDASVAVDEGALLPNGGHRGGNLALVFEMLA-ML 236

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           +   S         +   +    + I+ D    G     +LQ  +  +       +   +
Sbjct: 237 AGRESSKSAANRGDEPPRVGLFALVIDPDFF--GAGTLGRLQAHLATLA------DEHEV 288

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +PG              + +DD+ W K+
Sbjct: 289 YIPGRTRPAPAE------LDIDDATWEKL 311


>UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobiales
           RepID=B1M8T8_METRJ
          Length = 329

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 70/336 (20%), Positives = 133/336 (39%), Gaps = 14/336 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +T  +  A     L+  G     A + A         G+  HG++R   +  Q+  G +
Sbjct: 3   NLTLSEAGALAADALVRCGTAEAAARSVARALVGAEADGLKGHGLSRVAPYAAQVRAGKV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           + DA P        +   DA            ++    LA   G+    +R ++H    G
Sbjct: 63  VGDAVPLASRPRPGLLAIDAAHGFAYPAIDLALEALPGLARQQGVAAAGIRRSHHCGAAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
               + AE+G + + + N+ A M PWG ++   GTNPL  A   P     +VD+++S  +
Sbjct: 123 RPVERLAEQGCVALLFANTPAAMAPWGGRQAVFGTNPLAFACPLPGGAPIVVDLALSKVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
              +      G  +P     D +G  T + G    +  ++P+G  KG+ ++++++++A  
Sbjct: 183 RANIVGAARRGEPIPEGWALDADGRPTTDAGAAL-DGTMVPLGDAKGTALALMVELLAAG 241

Query: 240 LSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       E +       D  G  Q+ + ++   L        +   +   + +      
Sbjct: 242 LVGARFAGEASSFLDAAGDPPGTGQLILVLDAAALSPDAP--ERFAALAGTIAA------ 293

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG     L       G+ V +++ A+I+AL
Sbjct: 294 QDGARLPGSRRLGLRRRAAEAGLDVAEALVAEIRAL 329


>UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1 Tax=Sulfolobus
           tokodaii RepID=Q96YT3_SULTO
          Length = 318

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 77/330 (23%), Positives = 140/330 (42%), Gaps = 32/330 (9%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  ++ ++    +L  RGV  E     A+ F      G YSHG+ R    ++ ++ G 
Sbjct: 1   MKIKVKEAESLVESILKKRGV--ENPSIIAKHFVEAELRGHYSHGLQRVIPLVKGIDLGT 58

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   I        +DA  SIG L    + +   E        L+A+RN++H    
Sbjct: 59  IRKTVQLTEIKREDNAVLYDANYSIGILVWHYLTESPKET-------LIAVRNSSHIGFL 111

Query: 121 GSYGWQAAEK-GYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFS 179
           G Y  + A + G   I   N+   +   G  +  I T P+ +AIP   I ++DMS+S  +
Sbjct: 112 GYYTRRIAMRLGKPAIMIGNAEPAVVKPGTAKKIISTTPISIAIPCEKIVVLDMSLSPIA 171

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   +  G ++P     + +G +T +P    +   +LP+G  KG  + I L+++ + 
Sbjct: 172 RGKIIEAKRKGEKIPYGVTVNKDGEITTDPDEALQGG-LLPIGGMKGFFLMITLELLVSF 230

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A   EV    D +      +  I +   +L       + L++ ++           
Sbjct: 231 LTGSALATEVQGVLDTTKSPNKGEFMIIL--PRLQSDCHGLSVLKQFVE----------- 277

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
               LPG     +L   +R+ I +D+ ++ 
Sbjct: 278 ---YLPGEHSDEML---KRDEIDIDEKLYN 301


>UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB62_OSTLU
          Length = 330

 Score =  249 bits (636), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 81/334 (24%), Positives = 145/334 (43%), Gaps = 19/334 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG-DI 61
           V  E+LK    + +   G + + A    ++       G  + G+ +         NG  +
Sbjct: 2   VPIEELKTTTTKAIRGIGYNEKDAKVILDVLMYAQLRGN-NQGIIKVTT------NGLAM 54

Query: 62  IPDAQPKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRN-ANHWMR 119
            PDA+P  +          D +++ G L   +    A E A +HG G+V   N +     
Sbjct: 55  APDAEPMVVTHETKLSAAIDGKKTQGMLVLAEATRVAHEKAKEHGFGIVGTCNTSTSTGA 114

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
            G Y    A++G I IC+  S   + P G+ +   GTNP+ V IPS+    ++DM+ S +
Sbjct: 115 LGYYCKSVADQGMISICFAQSPEFVAPAGSSKAIFGTNPIGVGIPSSEGAMVLDMATSAY 174

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIA 237
           S+  +   + AGR+LP     D  G LTK+P  +     I    G +K S +++V++++A
Sbjct: 175 SWFGVLEAKTAGRELPDGAAQDKNGVLTKDPNEVLDGGAIRTFDGGYKSSNLALVIELLA 234

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             L   A   ++            + + I+  K++     +     +M+ V +A +    
Sbjct: 235 GPLVGAAIEGKLAA-----KNWGNLIMVIDP-KMLGQADFEKNAAFVMNRVRNAPKQPGV 288

Query: 298 QAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQ 330
            AI LPG     +   N   G I V+ ++W  ++
Sbjct: 289 DAINLPGERGDAIAKANEAKGEIDVETNLWNNLK 322


>UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z109_9NEIS
          Length = 346

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 9/263 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  +QL+     VL + G   + A   +         G  SHG+   P ++  + N  
Sbjct: 1   MKLAAKQLEHVSRLVLKALGCKEKEAVIVSRHLVEANLRGHPSHGIGMLPFYVASVRNKT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GAI Q+  +R  G   A++ +D AI    + G+ L+ +RNA+H  R 
Sbjct: 61  LRPNQAARLVRDAGAILQFSGERGFGQRVAREAVDAAIWRVRETGVALLTVRNAHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS----IAVMPPWGAKECRIGTNPLIVAIPST---PITMVDM 173
           G YG Q A  G +G+ + N       ++ P+G    R G NP+ +A P T   P  ++D 
Sbjct: 121 GCYGEQLANAGLVGLFFVNVTDVHTPMVSPFGGTAGRFGGNPICIAFPGTDKHPAFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSI 231
           + S  SYG   V  LAG++       +  G+ + +P V+  E    + PM + KG G+  
Sbjct: 181 ATSRVSYGKTRVAYLAGQRFEEPVLQNHAGHPSHDPRVMWEEPQGTLRPMAHHKGGGLLA 240

Query: 232 VLDMIATLLSDGASVAEVTQDNS 254
             + +A LLS G +         
Sbjct: 241 ATEFLAGLLSGGGTSQPGAAAPG 263


>UniRef50_B7G5R1 Dehydrogenase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G5R1_PHATR
          Length = 392

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 77/334 (23%), Positives = 131/334 (39%), Gaps = 17/334 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ ++ +    + L   G D E A   AE+       G  + G+     +   L    
Sbjct: 61  VHVSVQEARETTAKALQMIGWDHEDAALQAEIMTAAELCGN-NQGL--VKMYQPALMAPS 117

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHG-IGLVALRN-ANHWM 118
                +P            +A +S G L A    D A+  A  +G I +V   N +    
Sbjct: 118 PNA-GKPTVERETPTSAVVNANQSPGMLAAVNAADLAVHKATTNGPIAIVTSYNTSTSSG 176

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMS 176
           +   Y  + A KG IGI   NS   +      +   GTNP+ V IP         DM+ S
Sbjct: 177 QLAFYVERMARKGIIGIAMANSPEFVAAAQGGKPVFGTNPIAVGIPQKDAVPFTFDMATS 236

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             +   L  ++     LP +  +  +G  T +   +     I   G  KG+G+++ ++++
Sbjct: 237 AIALFGLLTSKAQNTPLPSNVAYGKDGGWTTDAAEVLDGGAIATFGGHKGAGLALCIELL 296

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           A  LS  A +  V    S +     +FIAI+ + L D    ++K   ++  V ++     
Sbjct: 297 AGALSGSAVLGLVESKKSAKSW-GHLFIAIDPNALTD--DFESKTASVIAAVKAS----- 348

Query: 297 NQAIRLPGHEFTTLLAENRRNGI-TVDDSVWAKI 329
              IR+PG     +  E +  GI  V   +W  I
Sbjct: 349 GDNIRIPGERSANMSEERKAVGIMPVPQKIWESI 382


>UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=1
           Tax=Streptomyces ghanaensis ATCC 14672
           RepID=UPI0001AF065C
          Length = 319

 Score =  240 bits (613), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 79/322 (24%), Positives = 135/322 (41%), Gaps = 14/322 (4%)

Query: 12  FNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT 71
                   GV  +  D   E +      G  SHG+ +F  F  Q  +  + P   P+   
Sbjct: 1   MTTACTRAGVPGKGTDRVVEHYLDGELRGKPSHGLAKF-AFESQFFSQRVGP---PRIKH 56

Query: 72  SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKG 131
             GA+   D +R +G L+A   +  A   A   G+G+V + N   +    S+  Q AE+G
Sbjct: 57  ERGAMAVVDGRREVGPLSADFAVRLAARKARRLGVGVVGMVNCQRYGILASWSEQIAERG 116

Query: 132 YIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYGMLEVNRLAG 190
            +G+    S       GA+   +G NP+  A P++  T+  DMS ++   G+L   R +G
Sbjct: 117 LVGLVANTSRPEATVHGARTPFLGVNPVSFAFPTSDSTVSADMSTTLAPMGVLWEARRSG 176

Query: 191 RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVT 250
             LP D   D+ G  T +P      R  +  G  +G  +S+++ ++   L        V 
Sbjct: 177 SPLPPDCFVDEHGAFTDDPDAA---RAAMVFGEHRGFALSLLIQILTGSLFGFPMGERV- 232

Query: 251 QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTL 310
                 +     FIA++      G         + D V  A   +    +R+PG E    
Sbjct: 233 ---DSTWTTGYTFIALDPTFAGQGEEHLVANASLTDAVRQAATREGGS-VRVPGQEGKDR 288

Query: 311 LAENRRNG-ITVDDSVWAKIQA 331
            A  R+ G +T+D++++ ++QA
Sbjct: 289 AARARKTGRLTLDEALYKRLQA 310


>UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=1 Tax=Pseudomonas
           fluorescens Pf-5 RepID=Q4KAT3_PSEF5
          Length = 334

 Score =  236 bits (603), Expect = 9e-61,   Method: Composition-based stats.
 Identities = 64/331 (19%), Positives = 127/331 (38%), Gaps = 10/331 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++  + +    R  +  G   E A A AE        G+ S G      ++    +G I 
Sbjct: 10  LSLAEARDFAQRCCLQAGSSQEVAQALAEATVSAQGHGLASVGFEHLADYLHGFASGRIA 69

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+P       A+ + DA+  I  L   +      +     GI L AL N       G 
Sbjct: 70  GLAKPLITQVAPAMIRCDARAGIAQLGFDQAFGAVCDSTRQLGISLFALHNGFTCGELGY 129

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y  + A +G + + + N  A++   G ++    TNPL  A P     + ++D + S  ++
Sbjct: 130 YTRRLAAEGLVALAFCNGPALLTVAGQRQPIYSTNPLAFAAPCGDGRLLLIDQASSATAF 189

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             L     AG  +P     D +G  T        +  +L  G  +G+ ++++++++A  +
Sbjct: 190 VNLLKAAEAGEAIPEGWAVDAQGAATLSAREAM-HGALLAFGGSRGANIALLVEVLAGGV 248

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           + G    +     S         + I +   +     +A+L R M  + +         +
Sbjct: 249 AGGNWSLDAPDFRSGAQSPGSGLLVITIAPHLLDEQFEARLARQMQRLATL-------GV 301

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             PG       A  +  GI++  +++ ++ A
Sbjct: 302 HPPGQAKQQAWARAQIEGISLPMALYQQMAA 332


>UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium leguminosarum
           RepID=C6B4N9_RHILS
          Length = 334

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 71/335 (21%), Positives = 130/335 (38%), Gaps = 12/335 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++  ++L+       ++ G     A A  +        G    G   F  ++  L +G 
Sbjct: 6   MRMPIDELRQLALEACLACGGSPAMAKALVDATLSAACFGRTELGFPHFVDYLTSLRDGR 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  DA+P+    L A+ Q DA   I  L    + D  ++     GI ++  RN+      
Sbjct: 66  INGDAKPRFNHVLPALIQADADGGIAQLGFDLIYDDFVKCVKTFGISVLTQRNSYTAGEL 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSM 177
           G Y  + A+ G I I   N  A+M      E    TNPL   +P     P  ++D + S 
Sbjct: 126 GYYVRRLAQDGLISIAAANGPALMAAAEGGERVYCTNPLAFGVPMPEPLPPVVIDQATSA 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++  L     A   +      D+ G +T +P        +LP G +KG  ++++++M++
Sbjct: 186 TAFITLAEAAKAQLPIAHGMAIDETGAITTDPVKAMLG-ALLPFGGYKGGNIALIVEMLS 244

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             LS  A   +     S E+ ++     I +           + +  ++ + S       
Sbjct: 245 AGLSGAAWSLDAGHFLSGEHPVNAGMTVIALFPAAADSDFPERAKAQLERLRS------- 297

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +R+PG            + + VD  V   I+ L
Sbjct: 298 RGVRIPGDRTMPASV-AETDRLDVDIGVLETIRRL 331


>UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomicrobia
           RepID=B1ZP47_OPITP
          Length = 364

 Score =  233 bits (594), Expect = 9e-60,   Method: Composition-based stats.
 Identities = 82/329 (24%), Positives = 141/329 (42%), Gaps = 17/329 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQL---ENG 59
           V   Q  A        RG   + A A A   A  T  G+ +H   +    +  L     G
Sbjct: 7   VPEAQHNALVEAAYKKRGYSGQEAAAGARFCAEATRHGIRTHNALKALH-LDHLFGSGAG 65

Query: 60  DIIPDAQPKRITSL-GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWM 118
              P A+ +++ +     + W+A R +G  T    ++ A++LA  +G+G+V++ NA H++
Sbjct: 66  GCKPKAKIEKVKTRFRGAQVWNANRKLGQATGYAAIETAMKLADKYGVGMVSVDNAFHYL 125

Query: 119 RGGSYGWQAAEKGYIGIC-WTNSIAVMPPWGAKECRIGTNPLIVAIPSTP----ITMVDM 173
            GG Y  +AA +GYI     T ++A + P+G K   +GTNP     P+T       ++D 
Sbjct: 126 WGGGYVMEAARRGYIAYTNCTAALAEVVPFGGKYPTLGTNPHSWGFPTTGAIGYPIVIDW 185

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVL 233
           + S+ + G ++     G+QLP     D+ G  T +P      + +LP G  KG G+S++ 
Sbjct: 186 ATSVVAMGRVQQLLREGKQLPPGAAVDENGTPTTDPAKA---KYLLPFGAHKGYGLSLMN 242

Query: 234 DMIATLLSDGASV--AEVTQDNSDEYGISQIFIAI-EVDKLIDGPTRDAKLQR-IMDYVT 289
           +++   +           +Q    E G    F  +   D +  G     + Q   +  V 
Sbjct: 243 EIVGAFIGGSLPTLRNRWSQVTEGEKGTCCFFFQVWHPDAMNGGAFAQGRDQTGNVKAVI 302

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNG 318
                  N+   LPG       A + +NG
Sbjct: 303 GDILGHGNEGCMLPGQIEAEAAARSAKNG 331


>UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UJP8_SINMW
          Length = 331

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 85/338 (25%), Positives = 149/338 (44%), Gaps = 23/338 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++++ E+++A     L   G  +  A   A   A    +G    G+   P F + L  G 
Sbjct: 4   VELSREEIEAVCLAALTVHGAAAGNARPVARAIAMAEAAGNRVCGLYYLPIFCRHLAIGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+ +++ G     DA+    +          I+LA  +G+G +A+RN+ + +  
Sbjct: 64  VDGGAIPE-VSARGVTVTVDARSGFAHPAIAAGTPALIDLARSNGLGAMAVRNSYNCLAL 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSM 177
           G +    A+ G IGIC +N+ A + P GA     GTNPL  A+PS   TP  +VD S+S 
Sbjct: 123 GHHVHPLADAGLIGICVSNAPAAVAPPGAAAALFGTNPLAFAVPSKEGTPAILVDQSLSA 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            +   + + R  G  +P     D  G  T +  +  +   +LP G  KG+ ++++++++A
Sbjct: 183 VTKTEMILRRDRGEAIPAGWAQDRNGQPTTDAAIGLEG-SLLPAGGRKGANVALLVEVLA 241

Query: 238 TLLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             L+      E      D      + Q  IAI+      G        R  + + +   +
Sbjct: 242 AALTGSVLSTEASAFGNDEGGPPHVGQFLIAIDPGHFSAG--------RFSEAIDNLVAS 293

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            E   +RLPGH         R+  + VD  +W K++ L
Sbjct: 294 HEAAGVRLPGHSG-------RKQAVFVDADLWKKVRLL 324


>UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria RepID=A8I4Z4_AZOC5
          Length = 376

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 83/337 (24%), Positives = 143/337 (42%), Gaps = 7/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L A     L + G D+ T DA        +  GV SHGV     ++  LE G +
Sbjct: 25  RYREADLSAFCEAALRAAGADAPTVDAATRAMMHASRLGVDSHGVRLLNHYVSALEGGRV 84

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                   +   GA+   DA  + G L A   MDRA++LA+  GIG VA+RN++H+   G
Sbjct: 85  ARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAG 144

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
           ++   AAE+G++G+ + NS + +      E   GTNP+  A P       + DM+ S   
Sbjct: 145 AFALAAAERGFVGLAFCNSDSFVRLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVP 204

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +  + + R     LP D   D EG  T++   ++    +     +KG+G++ ++++ + L
Sbjct: 205 FNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDMLAPLGGAFGFKGAGLAGLVEIFSAL 264

Query: 240 LSDGASVAE----VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LS      +    V  D +    I    +A+     ++    +  + R +  +  +    
Sbjct: 265 LSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAFLEPEVYEEGMARYLRTLRRSRPTA 324

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +  PG           R GI VD +       L
Sbjct: 325 GGE-VLAPGDREWREADNRARMGIPVDPATAEAFAQL 360


>UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=2 Tax=Burkholderia
           multivorans RepID=B9BUQ2_9BURK
          Length = 323

 Score =  223 bits (569), Expect = 7e-57,   Method: Composition-based stats.
 Identities = 67/335 (20%), Positives = 130/335 (38%), Gaps = 21/335 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK   E         +   G     A + A+       +G  + G    P ++     G 
Sbjct: 1   MKYEQEAAWRVAFDAIRRAGASEAVAHSLADAVISAELAGSKAVGFAHLPDYLDGFVIGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  DA+P       A  + DA+  I  L   ++ D  +  +  +G+  +A+ N+      
Sbjct: 61  IAADAEPDVSFPALAAIRADARGGIAQLAYDRVFDELVGRSNTYGVVTLAVSNSFTVGEL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G Y  + AE+G + +   N+ A M    + +   GTNP+  A P  +    ++D + S  
Sbjct: 121 GYYTRRLAERGLVALGTCNATAQMTTLESGKAVYGTNPVSFAAPVANARPFVIDQASSAT 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++  +     AG  +P     D+ G  T +      N  +LP G  +G+ ++++++++A 
Sbjct: 181 AFVSVRKAAEAGEAIPEGWAVDEHGRPTTDARAAI-NGLLLPFGGARGANLAMMMEILAA 239

Query: 239 LLSDGASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            ++ G     A      S+  G+    +A++ D            Q  +D ++ A     
Sbjct: 240 GVTGGNWSMDAPHYAKGSESPGVGLFVVAVKADVFAADFAARLAAQ--IDRLSKA----- 292

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              +R+PG              I V D V   +++
Sbjct: 293 --GVRIPGSHIKVRE-------IDVADDVMNNVRS 318


>UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2BBF
          Length = 329

 Score =  219 bits (558), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 74/324 (22%), Positives = 124/324 (38%), Gaps = 12/324 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +   +L+      ++  G   + A + A              G      ++  LE G 
Sbjct: 10  VSLPATELERLCTSAILDAGGSEKLAASLAAATVAADRRDKIQVGTAHLFDYLDGLEAGR 69

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I   A P+ +  L A    DA   I  L   ++ DR  + A D GI ++ + NA      
Sbjct: 70  INGAAVPRSVNRLPAAHLVDADGGIVQLAFDEVFDRFAQSATDLGISILNIMNAFPAGEL 129

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y  + A +G I +   NS A+M  +G+++   GTNPL  A+P      M D + S  +
Sbjct: 130 GYYTMRLARRGLIALAGGNSPALMSLFGSRDTVTGTNPLSFALPHPQGPRMFDQASSATA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +  +      G  +P       +G  T +P        +LP G  KGS ++++++++A  
Sbjct: 190 WVNIRDAADRGESIPEGWSQAPDGTATTDPEAGLAG-SLLPFGGVKGSNLALMIELLAAH 248

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLID-----GPTRDAKLQRIMDYVTSAE 292
                   +     + +   G     IAI  D              A+L R  ++     
Sbjct: 249 -GGANFSVDAPPIDEGTTTPGTGLFVIAISADAFDPEYTLRVEEHLARLDR--EFGIDFG 305

Query: 293 RADENQAIRLPGHEFTTLLAENRR 316
           R   +  I LPG   T LL    R
Sbjct: 306 RKRNDTVINLPGDLHTALLERAAR 329


>UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RZN2_9GAMM
          Length = 375

 Score =  219 bits (558), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 70/343 (20%), Positives = 126/343 (36%), Gaps = 24/343 (6%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E L  + ++V  + G+  E A   A+        G  + G+  +      LE G + P A
Sbjct: 11  EFLHFSLSQVAQAAGMSEEHAGYIADAIVFAHRQGKLNQGLGVYEAIDLVLEIGVLDPLA 70

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
            P+ +    A   +D + S G  T   M   AIE A ++GI +    N N      SY  
Sbjct: 71  VPEMVDEGPAFAVFDGKGSSGYYTLTLMAKAAIEKAREYGIAIAFGGNHNDGGSFASYVH 130

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY--GML 183
            A E+G +GI   N++ +  P+GA E  +   P    IPS     +  S+    +    +
Sbjct: 131 MAYEQGMVGIASNNTVPLAAPFGAMENMLSCPPFDAIIPSGKEPPIWASLKFAEWYDADI 190

Query: 184 EVNRLAGRQLPVDGGFDDE-GNLTKEPGVIEK------------------NRRILPMGYW 224
               L  + +      D E G LT       K                    R   +  W
Sbjct: 191 SEAVLQDKPMKGKWLIDPESGELTDNAKPYAKPIPGYGRVWDATCAGQIETPRTYALNLW 250

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
              GM  +++ +    ++  ++ +    N+        F+ I+  +         +  + 
Sbjct: 251 N-EGMCSIINPLGKPSTELPTIEDFAAGNAAPSVGGSYFMCIDPSRFGPLAAVQERSDKF 309

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
           ++ V +A+       +R+PG      L +N    + V ++ WA
Sbjct: 310 INKVRNAKPRPG-HRVRIPGESGYRSLTQNEPT-VEVLENHWA 350


>UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3MEC9_RHISN
          Length = 381

 Score =  218 bits (555), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 62/311 (19%), Positives = 118/311 (37%), Gaps = 16/311 (5%)

Query: 22  DSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDA 81
              T  +           G  + G      ++    +G I  + QPK      A    DA
Sbjct: 68  TEPTTRSLVAATMSAALFGPPTLGFPHLVDYLDSFRDGRISTNPQPKLNRPFAAFFVSDA 127

Query: 82  QRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSI 141
            R I  L   +  D+ +E     G+ +    N+      G +  + A +G +G+  TN+ 
Sbjct: 128 DRGIAQLGFDQAFDQFVETVRHFGVAIFTQTNSYTAGELGYFVRRLAAEGIVGLAATNAN 187

Query: 142 AVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGG 198
           A++           TNPL    P    +P  ++D + S  ++  +      GR +P    
Sbjct: 188 AMVVAKPGGPAVYSTNPLAFGFPMGDGSPPMIIDQASSATAFVNIVAAASEGRSIPAGWA 247

Query: 199 FDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYG 258
            D +GN T++P +  K   +L  G  KG+ ++++++M++  LS G    +     S +  
Sbjct: 248 VDADGNDTEDPNLALKG-ALLAFGGRKGANVALMVEMMSAGLSGGPWSLDTPDFRSGDVS 306

Query: 259 ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNG 318
                  I +   +D   R A+ +   D +           + +PG   T+   +     
Sbjct: 307 PGVGMTVIAMMPGVDQAARIARARTQADRLAGL-------GVFIPGVTGTSKKEQ----- 354

Query: 319 ITVDDSVWAKI 329
           +T+   V  +I
Sbjct: 355 LTIPAGVHRRI 365


>UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma proteobacterium
           NOR51-B RepID=B8KS33_9GAMM
          Length = 354

 Score =  218 bits (555), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 60/312 (19%), Positives = 114/312 (36%), Gaps = 17/312 (5%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L      +L + G     A   A     +   G  +HG++  P ++Q  E G I   A 
Sbjct: 8   TLAKLATDILEAIGTPPTPAAQVAHSLLESDRRGAPTHGLSLLPLYVQMAEAGVIDATAT 67

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P       ++ + D + + G LT  + ++  I+ A   G+  + + +  H  R G +  +
Sbjct: 68  PVTHDLGASLARVDGRAAFGQLTGSEAVNVGIQKAQQQGVAAIGIGDGTHLGRLGEWAER 127

Query: 127 AAEKGYIGICWTNSIA---VMPPWGAKECRIGTNPLIVAIP----STPITMVDMSMSMFS 179
           A +     + + N+      +         +  NP+   IP    +    +VD + S  S
Sbjct: 128 ACDADIAFLAFGNTGGGALTVAGPNKASRVLAPNPIAFGIPTCGATENHVIVDFATSQVS 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMG----YWKGSGMSIVLD 234
              +     AG +L  D     +G +T +P         + P+G      KG G+ +  +
Sbjct: 188 GSRIREAANAGDRLNPDWVIAADGGITDDPQAFLDGLAALRPLGGASAGHKGFGLMVAAE 247

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA-ER 293
           M A+ ++ G    E        +    +F+ ++V +         +      YV S   R
Sbjct: 248 MFAS-MAGGLMAGEEEVPW---FTNGALFLLLDVTRFAPREAWAGRAGAFTRYVESCGYR 303

Query: 294 ADENQAIRLPGH 305
              +   R PG 
Sbjct: 304 MPGSGGTRGPGD 315


>UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium RepID=B6A0G2_RHILW
          Length = 333

 Score =  216 bits (550), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 57/303 (18%), Positives = 111/303 (36%), Gaps = 15/303 (4%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           + +A   R  ++ G    TA +  +        G    G      ++     G I  +  
Sbjct: 11  EAEALAMRACLAVGAGEATARSLVDATLSAAIYGPAMLGFPHMVDYLDSFREGRINCNPA 70

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P+      A    DA R I  L      D  +    + G+ +    N+      G Y  +
Sbjct: 71  PRCERPYPAFFVADADRGIAQLGFDLAFDDLLAAVRNFGLAVFTQTNSYTAGELGYYVRR 130

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGML 183
            A +G +GI  TN+ A++           TNP+    P    +   ++D + S  +Y  +
Sbjct: 131 LAGQGIVGIAATNANAMVVAKAGGPAVYSTNPMAFGFPLGEGSLPLIIDQASSATAYVNI 190

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
                  R +P     D+ G  T++         +LP G  KG+ ++++++M++  LS G
Sbjct: 191 VAAAAERRAIPEGWAVDEAGKDTQDAARAL-GGALLPFGGRKGANVALMVEMLSAGLSGG 249

Query: 244 ASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                    ++ S    +    +A+   +  DG     + +R  D +         + + 
Sbjct: 250 PWSLDTPSFREGSVSPAVGLTVVAMMPGRSDDG--LVERARRQTDRLQE-------KGVF 300

Query: 302 LPG 304
           +PG
Sbjct: 301 VPG 303


>UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB34_SCHJA
          Length = 232

 Score =  209 bits (534), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 46/219 (21%), Positives = 105/219 (47%), Gaps = 14/219 (6%)

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGM 182
            A ++G IG+ +TN+  ++ P  A++  +GTNPL +A P        ++DM+ S  + G 
Sbjct: 1   MALQEGLIGLAFTNTSPLVFPTRARKLAVGTNPLTLAAPGKVPDDHFVLDMATSAVALGK 60

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLDMI 236
           +E+NR  G ++P+  G D +G    +P ++     ++P+G       +KG G+ ++++++
Sbjct: 61  IEMNRRRGLEIPIGWGADQDGKTCVDPNLVVTKGGLMPLGGEEEHSGYKGYGLGMLVEIL 120

Query: 237 ATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             ++++      V +      +  + Q F+AI+      G   + +L   ++ + +    
Sbjct: 121 CGIIANADFGPNVRRWMTTEKQANLGQSFLAIDPKAFAPG--FEQRLSEYVNIMRNLPPV 178

Query: 295 DENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
           ++ + + +PG      + E  +  GI     +   +  L
Sbjct: 179 NDKEPVVVPGDFEREHMIECDQLGGIPYPPVLLESLNRL 217


>UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E470A0
          Length = 246

 Score =  208 bits (529), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 53/245 (21%), Positives = 105/245 (42%), Gaps = 24/245 (9%)

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
           D++P  +         D Q  +G +     + +AIE AA +GIG V +         G +
Sbjct: 5   DSEPVVLHETVGSAWLDGQGCLGAVVGSFAIKKAIEKAAQNGIGWVLI-------ILGLW 57

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYG 181
                +    G+C +N+       G+K+  +GTNP+ +A         + D ++++ +  
Sbjct: 58  NGFLCKHVNRGLCMSNTWPASVVPGSKQRVLGTNPICLAAAGLDGDYLLFDSALTVTAMR 117

Query: 182 MLEVNRLAGR-QLPVDGGFDDEGNLTKEPGVIEKNRRILPM-------GYWKGSGMSIVL 233
            ++    +G   +P   G D  G  T +   I  N  +LP+       G  KG G+ +++
Sbjct: 118 KVKEKTKSGDGSVPEGWGVDQNGQPTTDGASILNNGALLPLGGISPLTGGHKGFGLILLV 177

Query: 234 DMIATLLSDGASVAEVTQDNSD-----EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +++ ++L+  A  +++ + + +          Q FIAI+      G     +LQ ++DY 
Sbjct: 178 EVLTSVLAGSAFSSDIGKKDGESGAFVGKDFGQTFIAIDPSHFGGG--FSDRLQFLLDYC 235

Query: 289 TSAER 293
              E 
Sbjct: 236 RHLEP 240


>UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emericella nidulans
           RepID=C8VKP5_EMENI
          Length = 230

 Score =  192 bits (488), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 53/235 (22%), Positives = 97/235 (41%), Gaps = 35/235 (14%)

Query: 94  MDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECR 153
           M  AI+ A  +GIG+V++ ++NH+    +Y  QA +   I + +T+S   MPP+G KE  
Sbjct: 1   MAEAIKRAEIYGIGMVSVNHSNHFGMAATYVLQALQANMISLVFTSSAKQMPPFGGKETP 60

Query: 154 IGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGV 211
           +G  P     PS      ++D++ S                           +  ++ G 
Sbjct: 61  LGIAPFAAGAPSNREVPYILDIAPST------------------------PMSPQRKYGS 96

Query: 212 IEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSD--EYGISQIFIAIEVD 269
             + + +       GSG++I++D+++++L+      +V     D         FIAI+ D
Sbjct: 97  DRRTKGL-------GSGIAILMDIMSSVLTVAGFGGQVGDRYKDAKPQDAGHCFIAIKPD 149

Query: 270 KLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDS 324
                    A++  ++  V     A     +  PG     L  + RR GI   D+
Sbjct: 150 VCFSVDDLKARMDTLVQRVHGVIPAPGFSEVLFPGEPEQRLCLQRRREGIPYADA 204


>UniRef50_UPI0000D54A60 putative malate/L-lactate dehydrogenase n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D54A60
          Length = 234

 Score =  179 bits (456), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 39/230 (16%), Positives = 94/230 (40%), Gaps = 13/230 (5%)

Query: 111 LRNANHWMRGGSYGWQAAEKGYIGI--CWTNSIAVMPPWGAKECRIGTNPLIVAIPST-P 167
           ++N++H     +Y      KG + +  C   S A + P+G  +  +  +P+ +A P+   
Sbjct: 2   IKNSHHNGALAAYLLPVVAKGLVPMIKCSVPSAATVAPFGGTKALLTPDPMALAFPTNGE 61

Query: 168 ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI-EKNRRILPMGY--- 223
             ++D+S S+ +  M+    +       +     +G  T +P  + E N  ++P+G    
Sbjct: 62  PVIIDISASITTNNMIADKIVKNEMFDFNCLLTKDGIPTNDPKEVFENNGTVMPLGGLEY 121

Query: 224 -WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
             KG G+++ ++ ++  LS      ++         +S     I+ +          ++ 
Sbjct: 122 GHKGFGLALGIEALSQGLSGSGRSRKL-----KTMNLSIYIQVIDPNAFAGIDAFKNEMS 176

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + +   +    D+N  +R+PG        ++  NGI +       ++ +
Sbjct: 177 FLYNECINNPPIDKNNKVRMPGQNALLSRKKSIENGIYLSKETLKSLEEI 226


>UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rhizobium etli CFN 42
           RepID=Q2JYL8_RHIEC
          Length = 235

 Score =  172 bits (437), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 43/215 (20%), Positives = 75/215 (34%), Gaps = 3/215 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
               + ++   R   + G    TA +  +        G  + G   F  ++     G I 
Sbjct: 7   FDLAEAESLAMRACRAAGASEATARSLVDATLSAALYGPPAVGFPHFVDYLDSFREGRIN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D  P       A    DA R I  L  +      +E     G+ +    N+      G 
Sbjct: 67  RDPAPTCERPYPAFFAADADRGIAQLGFELAFKDLVEAVRTLGVAVFTQTNSYTTGELGY 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFS 179
           Y  + A +G +GI  TN+ A++           TNP+    P    +P  ++D + S  +
Sbjct: 127 YVRRLAGEGIVGIAATNANAMVVAKAGGPAVYSTNPMAFGFPLGDGSPPLLIDQASSATA 186

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK 214
           Y  +      GR +P     D+ G  T++     +
Sbjct: 187 YVNVAAAAAEGRSIPEGWAVDEAGQETQDAARAAE 221


>UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2'
           RepID=UPI000169989B
          Length = 167

 Score =  170 bits (432), Expect = 6e-41,   Method: Composition-based stats.
 Identities = 41/169 (24%), Positives = 80/169 (47%), Gaps = 7/169 (4%)

Query: 85  IGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVM 144
           +G + A    D AI+LA+ +G+G+V + ++N     G Y  + A+ G + + W NS   +
Sbjct: 1   MGQVAA----DTAIDLASKNGVGVVTVSDSNFLGSLGYYVDKIAKNGMLAVLWNNSFPKV 56

Query: 145 PPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDE 202
            P+G  +  +GTNPL  A P       + D+S    +   +      G+ +P       +
Sbjct: 57  APYGGVKAVLGTNPLAFAAPRRNGRNVIADLSTGASAGSTITKAAELGQPIPEGIAIARD 116

Query: 203 GNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ 251
           G    +P  + K+  +LP G  KG  + ++++++A +++       V  
Sbjct: 117 GTPITDPAKV-KDGALLPFGGAKGYALGLMVEIMAGVVTGAGISHGVHS 164


>UniRef50_A6D9E5 Putative uncharacterized protein n=1 Tax=Vibrio shilonii AK1
           RepID=A6D9E5_9VIBR
          Length = 391

 Score =  135 bits (341), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 47/320 (14%), Positives = 97/320 (30%), Gaps = 30/320 (9%)

Query: 17  ISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAI 76
              G D   AD  A         G    G+          E G + P + P+  +     
Sbjct: 25  KHIGADQTHADILAHNLLVGGLQGKLHQGLGVIEAVTIPYEAGILDPTSTPELESEGDTW 84

Query: 77  EQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGIC 136
             ++ ++S G+     M   AIE A  HGI +V   +        +Y   A ++G   + 
Sbjct: 85  AVYNGKKSSGHYVCTLMAQTAIEKARKHGISIVFGYDHCDGGNFSNYTQMAMKEGMFAMS 144

Query: 137 WTNSIAVMPPWGAKECRIGTNPLIVA-IPSTPITMVDMSMSMFSYGM-----LEVNRLAG 190
             NS+ +  P+G  +  +   P   A +    + +V    +    G      +    +  
Sbjct: 145 SNNSVPLNAPFGGMDPAMSCPPFDAALVGGEELPLV----TSIMIGEGYDSHICDAIVND 200

Query: 191 RQLPVDGGFDDE-GNLTKEP----------GVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           R L V    D + G LT +           G +   +        +   ++I  +++  +
Sbjct: 201 RDLHVAALVDQDTGELTADARKWGSLIEGYGRVADCKAPWTFLTPRLYSLNIWNEVMTAI 260

Query: 240 LSDGASVAE---------VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           ++    +A           T +++         + I+            K    +  +  
Sbjct: 261 INPKGKIAPELPAVPSDFFTMEDAPCPVGGSYILVIDPSHFGPIEEVKRKSDMFVKAIKE 320

Query: 291 AERADENQAIRLPGHEFTTL 310
                    + +P       
Sbjct: 321 NRPRAGFNEVYIPDEWGLKA 340


>UniRef50_UPI00016955AA hypothetical protein Plarl_18817 n=1 Tax=Paenibacillus larvae
           subsp. larvae BRL-230010 RepID=UPI00016955AA
          Length = 331

 Score =  132 bits (333), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 59/335 (17%), Positives = 110/335 (32%), Gaps = 29/335 (8%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           T E L+          G+    A   +E        G+ SHG+ R     +QL      P
Sbjct: 12  TIESLRQKVQNRFEQAGLSEYQAREMSEQLLYAEMRGISSHGLVRIKWVTEQLHK---YP 68

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
               + +      E +DA   +G L   ++ ++  +      I  + +RN         +
Sbjct: 69  LKNVRLLLQNREAELYDADGVLGYLALNEVAEK-QQRFEGQTIKFIGIRNTYPTGALSYF 127

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST----PITMVDMSMSMFS 179
             + A KG+I +  + S   +  +G  +  +GTNP    +P         +VD+S+S  +
Sbjct: 128 SEKLAAKGWIVLMSSTSPRRVGLYGDDKGLVGTNPWTFTLPVETNYSGQVVVDVSLSEIT 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR----ILPMGYWKG---SGMSIV 232
           +G       AG+ LP        G     P  + K       + P+G  KG    G+   
Sbjct: 188 HGQCLKAVEAGQPLPNYAASQPGGLAINHPDDLWKEGNWNAILHPVGRDKGFKPFGVMWS 247

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           L ++ + +                       + +              ++   + V    
Sbjct: 248 LHVMGSRMLG----------LDGVESHGTFILLLSPSMWEPIIPAYEVIKGFNEEVKLLS 297

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
            +       +PG    + L E +   ITV   +  
Sbjct: 298 MSKVAH---VPGEGRMSRLKEQKDQ-ITVTQEIVN 328


>UniRef50_UPI0001AF36FA ureidoglycolate dehydrogenase n=1 Tax=Salmonella enterica subsp.
           enterica serovar Tennessee str. CDC07-0191
           RepID=UPI0001AF36FA
          Length = 131

 Score =  110 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 42/103 (40%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L       L   G+  E A   A++       G++SHG  R   + +++  G 
Sbjct: 1   MKISRETLHQLIENKLYKAGLKREHAAIVADVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAAD 103
              +   +   +        A  + G + AK  M+ AIE+A  
Sbjct: 61  TNREPTFRIENTGPCTAILHADNAAGQVAAKMGMEHAIEIAKK 103


>UniRef50_C8Q676 Putative malate/lactate dehydrogenase n=1 Tax=Pantoea sp. At-9b
           RepID=C8Q676_9ENTR
          Length = 132

 Score =  110 bits (275), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 26/109 (23%), Positives = 45/109 (41%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            +   L+    + L   GV   TA   A+    ++  G  SHGV+  PR+I  +  G++ 
Sbjct: 4   FSHTWLRQYLRQHLQVAGVRPATAGEVADNLVESSLKGHDSHGVSLIPRYIAAIRAGELD 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVAL 111
             A        G +  +      G +  + +M++AI  A   G  +V L
Sbjct: 64  AQATISLTRDTGPMLSYHGNNGFGQVNGRLVMEQAILRARRFGACVVGL 112


>UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC
           18224 RepID=B6QNX4_PENMQ
          Length = 136

 Score =  104 bits (261), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 4/119 (3%)

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLID- 273
           +LP+G  KGSG+++++D+   LL+  +   +V     +  +  G+   F+  + +  +D 
Sbjct: 1   MLPIGGAKGSGLAMMMDIFGALLTASSFAGDVNDQYNNTRNPQGVGHWFMVFKPETFLDS 60

Query: 274 GPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 ++  ++  V   E+ +    IR+PG   T +    R  GI         +  L
Sbjct: 61  RDELADRMDTLLGRVRPCEKVEGVDRIRVPGENATEMETRRRFEGIPFTAVELKNLNLL 119


>UniRef50_C1ZI52 Malate/lactate dehydrogenase n=1 Tax=Planctomyces limnophilus DSM
           3776 RepID=C1ZI52_PLALI
          Length = 351

 Score = 87.9 bits (217), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 48/306 (15%), Positives = 104/306 (33%), Gaps = 33/306 (10%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTE--SGVYSHGVNR--FPRFIQQL 56
           + +    L+ +  +VL  +G+    +    +          G    G++       ++ +
Sbjct: 22  VSLQVADLQQSILKVLTRQGLFGADSQHVIDYILSPWLPAWG----GLHLPYLSSMVRAM 77

Query: 57  ENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANH 116
           + G+I P  +   +    ++   D  R+ G++      +  +E A   GI    +RN++ 
Sbjct: 78  DLGEIDPRGRILTVRDQPSLVHLDGSRAAGSVAMAYATELLVEKAKATGIAGAVIRNSSA 137

Query: 117 WMRGGSYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSM 175
             R  +     A +G IG   +++  A   P G +  R+  +     +P+     + +S 
Sbjct: 138 IDRPEAVVANLAHRGLIGFMVSSTGRAEFSPVGDRTPRVAGHRSAWCLPAASSLTL-IST 196

Query: 176 SMFSYGMLEV---NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIV 232
            + S   L +    +  G+    D  FD EG   +          +   G          
Sbjct: 197 QVASLDSLMLLDPAQTEGQP-AADLAFDKEGQPARSWNSARTFGLLT--GEH-------- 245

Query: 233 LDM--------IATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
            D+        +   LSDG    E  + +        + +AIE    +       +L   
Sbjct: 246 -DLQYGLLCGLLLAALSDGRLPTERAKKSPFGDDSEHLLLAIEPSSEMAERFPPERLAAF 304

Query: 285 MDYVTS 290
           +  +  
Sbjct: 305 VSSMKH 310


>UniRef50_UPI0001B54124 malate/L-lactate dehydrogenase n=1 Tax=Streptomyces sp. AA4
           RepID=UPI0001B54124
          Length = 187

 Score = 79.8 bits (196), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 38/237 (16%), Positives = 77/237 (32%), Gaps = 65/237 (27%)

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           ++ A   G+GL+++R    + R G +  +A   G IGI             A +      
Sbjct: 1   MQRAGRFGVGLLSVRGVGPFGRVGHHAARALPHGMIGIVMA------AGGYADQPVH--- 51

Query: 158 PLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           PL +A P+   P  + D+ ++  +                            +P      
Sbjct: 52  PLGMAAPAGAYPEFVFDIDLADAAR---------------------------DPRFA--- 81

Query: 216 RRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGP 275
                       G ++++D++A +LS  A           E+    + +AI    L    
Sbjct: 82  ------------GFALMVDVLAGVLSGVA---------DHEHDTGLLVLAIAPTTLRSAD 120

Query: 276 TRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                   +   +      +    +R PG      L + R  G+ +  +V  ++ +L
Sbjct: 121 GFYRAASAVFGSMLG---WEGGAPVRYPGWREAQYLEQCRALGVPLPGAVRRQLDSL 174


>UniRef50_B5JCB8 Putative uncharacterized protein n=1 Tax=Octadecabacter antarcticus
           307 RepID=B5JCB8_9RHOB
          Length = 128

 Score = 71.3 bits (174), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 58/124 (46%), Gaps = 3/124 (2%)

Query: 212 IEKNRRILPMGYWKGSGMSIVLDMIATLLSDG---ASVAEVTQDNSDEYGISQIFIAIEV 268
              +  +  +G  KG+ +S+ LD+    LS G     VA+  +  S +  +S +F+ ++ 
Sbjct: 2   AALSGILQAIGGAKGANLSMCLDLFQGRLSGGVILGKVADQHKGPSRQQDLSLMFLLVDP 61

Query: 269 DKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAK 328
             L +  +    +   +  + + E AD   A+RLP     + + ++ R G+ +   + A+
Sbjct: 62  KALEEVNSSGETIADALKQIENNEPADPAAAVRLPNARAVSQIRKSERAGLRLSAPLLAQ 121

Query: 329 IQAL 332
           ++ L
Sbjct: 122 LEKL 125


>UniRef50_A4FCS6 Putative uncharacterized protein n=1 Tax=Saccharopolyspora
           erythraea NRRL 2338 RepID=A4FCS6_SACEN
          Length = 158

 Score = 69.8 bits (170), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 21/110 (19%), Positives = 45/110 (40%), Gaps = 10/110 (9%)

Query: 222 GYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAI-EVDKLIDGPTRDAK 280
           G  KGSG+++V+  ++ +++  A+      D         +FIA+ +   L +      +
Sbjct: 3   GGHKGSGLAMVVR-LSGMMTGAAAAPPGVSD-------CALFIALVDPGVLTEPADYRRR 54

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKI 329
           +    D + +A   +    +R+          E  R G I V ++V   +
Sbjct: 55  IATFADSIRAARPVEGGSTVRVSFDRSVACREETLRRGTIDVPEAVVTAL 104


>UniRef50_A4FJI4 Putative uncharacterized protein n=1 Tax=Saccharopolyspora
           erythraea NRRL 2338 RepID=A4FJI4_SACEN
          Length = 133

 Score = 65.9 bits (160), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 17/115 (14%), Positives = 38/115 (33%), Gaps = 4/115 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T    +A     +      ++ A+  A+        G+   G+ R    ++++      
Sbjct: 4   LTLSDARALATATMTRISHTADEAEIIADHLLDCELRGLLFGGLARALSIVERIRATPES 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIEL-AADHGIGLVALRNANH 116
           P  + + +         D    +G     + ++ A    A   G  +V  RN  H
Sbjct: 64  P-GRIRIVAQTAVSATLDGGDKVGYFVGMRALELAWTRHAR--GSAIVGARNLVH 115


>UniRef50_C8Q675 1-aminocyclopropane-1-carboxylate deaminase-like protein n=1
           Tax=Pantoea sp. At-9b RepID=C8Q675_9ENTR
          Length = 245

 Score = 62.8 bits (152), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)

Query: 188 LAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
           + G +LP +   D+     ++P  +  E    +L  G  KGSG+S+V  ++   L+ G +
Sbjct: 1   MKGAELPANCAIDNTKKPIRDPRWLMQEPLGALLAFGVHKGSGLSLVCSLLGAALTGGDT 60


>UniRef50_UPI00016A6773 hypothetical protein BuboB_33537 n=1 Tax=Burkholderia ubonensis Bu
           RepID=UPI00016A6773
          Length = 103

 Score = 59.4 bits (143), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 22/57 (38%), Gaps = 4/57 (7%)

Query: 192 QLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAE 248
           ++P     D  G  T +P V+ +     P G  KG  ++ + ++    L  G     
Sbjct: 13  RVPAGSLIDHRGRPTDDPAVMHEQ----PFGLHKGYALAAMCEIFGGALGVGGHTTH 65


>UniRef50_UPI0000E47CD4 PREDICTED: similar to MGC80281 protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E47CD4
          Length = 461

 Score = 58.6 bits (141), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 10/58 (17%), Positives = 28/58 (48%), Gaps = 6/58 (10%)

Query: 206 TKEPGVIEKNRRILPMGY------WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEY 257
           T +P  +  +  + P+G       +KG+G+++++++I  +L        + + +  E 
Sbjct: 9   TSDPKEVLNDGGLQPLGGGETTGGYKGTGLALMVEVITGILGGAHFGTNIRKWSGGER 66


>UniRef50_Q28KZ8 Malate/L-lactate dehydrogenases-like protein n=1 Tax=Jannaschia sp.
           CCS1 RepID=Q28KZ8_JANSC
          Length = 233

 Score = 58.2 bits (140), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 39/117 (33%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
               L+      L   GV   TA   A+  A     G    G     R I+ +  G I  
Sbjct: 6   DLSDLEMLAKDCLTRAGVGDATARVVAQDVALAEAYGDAESGFEALLRDIRLVRYGRIYA 65

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           DA+    T   A+ + DA          + +   IE A   G+ +V L  A+     
Sbjct: 66  DAKVNISTPTPAVIRVDAGHGFAAFALAEALPSVIEAALSQGLAMVHLTRASDPGSM 122


>UniRef50_Q88JF9 Putative uncharacterized protein n=2 Tax=Pseudomonas putida
           RepID=Q88JF9_PSEPK
          Length = 233

 Score = 55.9 bits (134), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 23/135 (17%), Positives = 49/135 (36%), Gaps = 11/135 (8%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V+  +++    +     G      +  AE+       G+   GV    + ++ L+   
Sbjct: 3   MRVSLNEIQVMCRKAFEGMGFAPGDCEDAAELVGWLQLQGLD--GVGALEKALRYLQAEA 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKM---MDRAIELAADHGIGLVALRNANHW 117
             P A         A+   DA+   G    +     ++ A   A   G   + +R+ ++ 
Sbjct: 61  ARPYA---LCHEDNALLVIDAK---GQSVLRCAATVVELAAAKAMRCGQAELRIRHCHNR 114

Query: 118 MRGGSYGWQAAEKGY 132
           +    Y  +AA +G 
Sbjct: 115 LLLLGYLSRAAVQGL 129


>UniRef50_A3JD36 Putative uncharacterized protein n=2 Tax=Gammaproteobacteria
           RepID=A3JD36_9ALTE
          Length = 255

 Score = 54.7 bits (131), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 23/132 (17%), Positives = 44/132 (33%), Gaps = 4/132 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV+F +L+    +     G D   A   A+M       G+   G+    R +  +    
Sbjct: 1   MKVSFNELQGLSRKAFSGVGFDDGDASDAADMVVWMEAHGLN--GIQSLKRSLAFILEE- 57

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
                 P+ I     +   DA        A   ++         G+ +  +R+ ++ M  
Sbjct: 58  -DQSHSPEIIYQDADLCVVDAHNRTALNNASLAIELGYAKCRARGLSVTKIRHCHNRMLI 116

Query: 121 GSYGWQAAEKGY 132
             Y  + A +  
Sbjct: 117 VGYLSRVARRNM 128


>UniRef50_A7TC77 Predicted protein n=4 Tax=cellular organisms RepID=A7TC77_NEMVE
          Length = 509

 Score = 52.8 bits (126), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 43/115 (37%), Gaps = 4/115 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V+  +LKAA  R   + G      +  A M     + G+   G+    R +  +    
Sbjct: 261 MHVSMNELKAALRRCFEATGYFVGNYEDAANMILWLEKHGLG--GLKELERALPFIGVDR 318

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNAN 115
             P +      S  AI     + ++  + A   +D A   A + GI  V + N +
Sbjct: 319 DKPLSTVVYEDSTSAIIDSHGRSALNCIAAS--VDLAHAKALECGIATVTVHNCH 371


>UniRef50_A7IHR1 Putative uncharacterized protein n=1 Tax=Xanthobacter autotrophicus
           Py2 RepID=A7IHR1_XANP2
          Length = 151

 Score = 50.5 bits (120), Expect = 9e-05,   Method: Composition-based stats.
 Identities = 11/45 (24%), Positives = 18/45 (40%)

Query: 117 WMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIV 161
               G    Q A  G +   + N++A +   G      GTNP+ +
Sbjct: 25  CGVVGYRAEQIATAGRVAFGFVNALASIALTGGVTPVFGTNPIAI 69


>UniRef50_B5JCB7 Putative uncharacterized protein n=1 Tax=Octadecabacter antarcticus
           307 RepID=B5JCB7_9RHOB
          Length = 56

 Score = 50.1 bits (119), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 143 VMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGMLEVNRLAGRQLPVD 196
           ++   G +E  IG NP+ + +P       ++D+++SM +   +   R  G  +P+D
Sbjct: 1   MIATAGGREALIGNNPVRIGVPLSGRDPVLMDIALSMGARSRVRAARDEGDAIPLD 56


>UniRef50_B7RV64 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RV64_9GAMM
          Length = 253

 Score = 49.0 bits (116), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 19/115 (16%), Positives = 34/115 (29%), Gaps = 5/115 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV+  ++ A   +V           ++ A+M       G+   G+      +  L    
Sbjct: 1   MKVSKNEITALLKQVFEGLKFRCGEYESAADMIVWAEMCGLS--GLLALRHSLPYLTE-- 56

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNAN 115
                  + I         DA        A  +M+ A   A       V + N +
Sbjct: 57  -QSPPPLRSIHESETKAVLDANNGSSLNCADVVMNLAYTKALAQECCSVTVLNCH 110


>UniRef50_Q9KZG1 Putative uncharacterized protein SCO6991 n=1 Tax=Streptomyces
           coelicolor RepID=Q9KZG1_STRCO
          Length = 68

 Score = 47.8 bits (113), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 10/53 (18%), Positives = 17/53 (32%)

Query: 279 AKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           A +   +  +     A     +  PG   T    E   +G+ V   VW  +  
Sbjct: 3   AAVDETLGTLKGPPLAHGADGVYYPGERSTARDVERAADGVPVAPKVWRDLTE 55


>UniRef50_Q89R00 Bsr2972 protein n=1 Tax=Bradyrhizobium japonicum RepID=Q89R00_BRAJA
          Length = 75

 Score = 46.6 bits (110), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/53 (22%), Positives = 22/53 (41%), Gaps = 4/53 (7%)

Query: 277 RDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            DA++ R +D+    +       + +PG        +  +NGI + D   A I
Sbjct: 8   FDAEVLRHVDF----KPVAGLDQVLIPGDPGRKTRIQRTQNGIPLPDDTRAAI 56


>UniRef50_B5JCB5 Putative uncharacterized protein n=1 Tax=Octadecabacter antarcticus
           307 RepID=B5JCB5_9RHOB
          Length = 50

 Score = 44.7 bits (105), Expect = 0.005,   Method: Composition-based stats.
 Identities = 12/50 (24%), Positives = 19/50 (38%)

Query: 79  WDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAA 128
            D    +  L A + ++   + A   G+G V +R   H      Y W A 
Sbjct: 1   MDGCGGLCPLIAMRALEAGRDAARRAGVGAVFVRGGTHVGALAPYLWYAT 50


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_P...   408   e-112
UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2...   381   e-104
UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococ...   379   e-104
UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia T...   377   e-103
UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobac...   376   e-103
UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax...   373   e-102
UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q...   371   e-101
UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Baci...   368   e-100
UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus ...   363   4e-99
UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular ...   362   9e-99
UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacte...   361   1e-98
UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoana...   360   4e-98
UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxy...   360   4e-98
UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobu...   360   5e-98
UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5               359   8e-98
UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogen...   359   9e-98
UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistoso...   356   6e-97
UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaeroba...   355   1e-96
UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VE...   354   2e-96
UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria ...   353   5e-96
UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=...   353   5e-96
UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomi...   353   6e-96
UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B...   352   7e-96
UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfito...   352   1e-95
UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobact...   352   1e-95
UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostri...   351   1e-95
UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium ...   351   2e-95
UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria...   350   4e-95
UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophu...   350   5e-95
UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bact...   349   9e-95
UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyru...   348   2e-94
UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular ...   346   8e-94
UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus...   344   3e-93
UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunctio...   344   4e-93
UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus So...   342   9e-93
UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba...   340   3e-92
UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2     340   4e-92
UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria ...   340   5e-92
UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacter...   339   6e-92
UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammap...   339   7e-92
UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostri...   339   7e-92
UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizo...   337   2e-91
UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria...   337   3e-91
UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenel...   337   3e-91
UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyc...   335   1e-90
UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspi...   334   2e-90
UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coeloma...   334   3e-90
UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62...   334   3e-90
UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=A...   330   4e-89
UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydro...   330   4e-89
UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=...   330   5e-89
UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesen...   329   9e-89
UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerot...   327   4e-88
UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostri...   327   5e-88
UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. ...   327   5e-88
UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacil...   326   8e-88
UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacill...   326   8e-88
UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococ...   325   1e-87
UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyc...   325   1e-87
UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha pro...   325   1e-87
UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp...   324   2e-87
UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfona...   324   2e-87
UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN...   323   6e-87
UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella...   323   7e-87
UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteri...   323   7e-87
UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclo...   322   7e-87
UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteo...   322   1e-86
UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Pro...   322   1e-86
UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   322   1e-86
UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=S...   322   2e-86
UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...   320   3e-86
UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine b...   320   4e-86
UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimon...   319   9e-86
UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evid...   319   9e-86
UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 ...   318   2e-85
UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   318   2e-85
UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobac...   317   2e-85
UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   317   3e-85
UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IP...   317   4e-85
UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium...   317   4e-85
UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobac...   316   6e-85
UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH     316   7e-85
UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   315   1e-84
UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfo...   315   1e-84
UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomy...   315   2e-84
UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   314   3e-84
UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family ...   314   4e-84
UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomon...   313   7e-84
UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat...   312   1e-83
UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobac...   310   3e-83
UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C...   310   5e-83
UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia...   310   6e-83
UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis...   308   1e-82
UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...   308   2e-82
UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostri...   308   2e-82
UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organis...   307   3e-82
UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadec...   306   7e-82
UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholde...   306   8e-82
UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitoba...   305   9e-82
UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...   305   2e-81
UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris ...   303   6e-81
UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria ...   302   9e-81
UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID...   302   1e-80
UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=...   302   1e-80
UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaprot...   302   1e-80
UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricauli...   301   2e-80
UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_...   300   5e-80
UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobact...   299   8e-80
UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=...   298   2e-79
UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogen...   297   4e-79
UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovora...   296   6e-79
UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomy...   296   6e-79
UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax...   295   1e-78
UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS         295   1e-78
UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostri...   295   1e-78
UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteoba...   295   1e-78
UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria ...   295   2e-78
UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriac...   295   2e-78
UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=...   294   3e-78
UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochl...   294   3e-78
UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax...   292   9e-78
UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME       290   3e-77
UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobial...   290   6e-77
UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaprot...   289   1e-76
UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangiu...   288   2e-76
UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NG...   287   4e-76
UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha prote...   286   6e-76
UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Ac...   286   7e-76
UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=...   285   1e-75
UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobi...   285   1e-75
UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax...   285   1e-75
UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Co...   285   2e-75
UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacte...   285   2e-75
UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burk...   284   3e-75
UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...   283   4e-75
UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccu...   283   4e-75
UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   283   4e-75
UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   283   5e-75
UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...   283   6e-75
UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   283   7e-75
UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   282   1e-74
UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromon...   282   1e-74
UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteoba...   281   2e-74
UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobia...   280   3e-74
UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2...   280   4e-74
UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria ...   280   5e-74
UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata ob...   279   1e-73
UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacte...   279   1e-73
UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=...   278   2e-73
UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae...   277   3e-73
UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphapro...   277   3e-73
UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionace...   276   7e-73
UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonoc...   275   1e-72
UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus...   274   3e-72
UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobac...   274   3e-72
UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativo...   274   3e-72
UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...   273   6e-72
UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella...   270   5e-71
UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaprot...   270   6e-71
UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Ta...   269   1e-70
UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovora...   268   2e-70
UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=...   268   3e-70
UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobac...   263   4e-69
UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsi...   263   7e-69
UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=...   263   9e-69
UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=...   262   9e-69
UniRef50_B7G5R1 Dehydrogenase n=1 Tax=Phaeodactylum tricornutum ...   262   2e-68
UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=...   260   4e-68
UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=...   259   1e-67
UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98C...   258   1e-67
UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholde...   257   4e-67
UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB...   256   1e-66
UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaprot...   255   2e-66
UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1...   251   2e-65
UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=...   251   3e-65
UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinoba...   251   3e-65
UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lip...   248   1e-64
UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=...   247   5e-64
UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium...   247   6e-64
UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobial...   246   7e-64
UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=...   243   8e-63
UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemoph...   238   1e-61
UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella ...   236   6e-61
UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomi...   235   1e-60
UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate deh...   232   1e-59
UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=...   229   1e-58
UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria...   228   2e-58
UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium...   226   7e-58
UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacteri...   225   2e-57
UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizo...   224   3e-57
UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3M...   223   1e-56
UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein...   218   2e-55
UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma p...   215   2e-54
UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB...   211   2e-53
UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial ...   200   6e-50
UniRef50_UPI0000D54A60 putative malate/L-lactate dehydrogenase n...   191   2e-47
UniRef50_UPI00016955AA hypothetical protein Plarl_18817 n=1 Tax=...   186   1e-45
UniRef50_A6D9E5 Putative uncharacterized protein n=1 Tax=Vibrio ...   185   2e-45
UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rh...   179   9e-44
UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emerice...   171   3e-41
UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persepho...   155   2e-36
UniRef50_C1ZI52 Malate/lactate dehydrogenase n=1 Tax=Planctomyce...   131   3e-29
UniRef50_C8Q676 Putative malate/lactate dehydrogenase n=1 Tax=Pa...   111   3e-23
UniRef50_UPI0001AF36FA ureidoglycolate dehydrogenase n=1 Tax=Sal...   109   2e-22
UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicil...   106   1e-21
UniRef50_UPI0001B54124 malate/L-lactate dehydrogenase n=1 Tax=St...    93   2e-17
UniRef50_Q88JF9 Putative uncharacterized protein n=2 Tax=Pseudom...    78   5e-13
UniRef50_A4FCS6 Putative uncharacterized protein n=1 Tax=Sacchar...    78   6e-13
UniRef50_A4FJI4 Putative uncharacterized protein n=1 Tax=Sacchar...    77   1e-12
UniRef50_A3JD36 Putative uncharacterized protein n=2 Tax=Gammapr...    76   2e-12
UniRef50_B5JCB8 Putative uncharacterized protein n=1 Tax=Octadec...    76   2e-12
UniRef50_B7RV64 Putative uncharacterized protein n=1 Tax=marine ...    74   6e-12
UniRef50_A7TC77 Predicted protein n=4 Tax=cellular organisms Rep...    74   8e-12
UniRef50_Q28KZ8 Malate/L-lactate dehydrogenases-like protein n=1...    71   6e-11
UniRef50_C8Q675 1-aminocyclopropane-1-carboxylate deaminase-like...    63   1e-08
UniRef50_UPI0000E47CD4 PREDICTED: similar to MGC80281 protein n=...    55   3e-06
UniRef50_UPI00016A6773 hypothetical protein BuboB_33537 n=1 Tax=...    55   4e-06
UniRef50_B5JCB7 Putative uncharacterized protein n=1 Tax=Octadec...    51   7e-05
UniRef50_Q9KZG1 Putative uncharacterized protein SCO6991 n=1 Tax...    49   3e-04
UniRef50_A7IHR1 Putative uncharacterized protein n=1 Tax=Xanthob...    49   3e-04
UniRef50_Q89R00 Bsr2972 protein n=1 Tax=Bradyrhizobium japonicum...    46   0.001

Sequences not found previously or not previously below threshold:

UniRef50_Q1YQB4 Putative uncharacterized protein n=1 Tax=gamma p...    52   4e-05

>UniRef50_Q9V0D5 Malate dehydrogenase n=4 Tax=Archaea RepID=MDH_PYRAB
          Length = 362

 Score =  408 bits (1049), Expect = e-112,   Method: Composition-based stats.
 Identities = 88/340 (25%), Positives = 157/340 (46%), Gaps = 8/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  ++L +   RVL   G   E A   A+        G+ SHGV R  R++  + +G 
Sbjct: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    + K I    +    D     G +   K M  AIE A   GIG+VA+RN+NH+   
Sbjct: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFS 179
           G Y   AAE+G IGI  TNS  ++ P G  E  +GTNP+ +A P+     ++DM+ S+  
Sbjct: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVP 191

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR-------ILPMGYWKGSGMSIV 232
            G LEV R  G ++P     + +G +T+    +               +G  KG G+S++
Sbjct: 192 IGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLM 251

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +D+++ +LS G     V   N     +   F+AI ++          ++  +++ + ++ 
Sbjct: 252 VDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSR 311

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + + I + G +    +    + GI +   V  ++  +
Sbjct: 312 KHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEI 351


>UniRef50_Q2BFJ4 Malate dehydrogenase n=3 Tax=Bacillales RepID=Q2BFJ4_9BACI
          Length = 364

 Score =  381 bits (980), Expect = e-104,   Method: Composition-based stats.
 Identities = 85/336 (25%), Positives = 159/336 (47%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E+L+   + V I  GV  E A+  AE   +    G+ SHGV R   +I+++E   +
Sbjct: 6   KFDWEKLQKFCSDVFIKAGVKREDAETVAESLIQADLRGIDSHGVVRTDIYIKRIEKNMM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A+        A    +    +G +   K +D A+  A + G  +V ++ +NH+  G 
Sbjct: 66  NPFAEISIEEETDATALVNGHNQLGAIVGSKALDLALHKAKEKGAAIVGVKGSNHFGTGA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFS 179
            Y  +A EK  I +  +N+   MPP G     IGTNPL + +P+      ++DM+ S+ +
Sbjct: 126 FYVSKAIEKDMILLVLSNASQTMPPTGGVRPFIGTNPLAIGVPAGEEEAFILDMATSVVA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G  +P+    D  GN T       +   +LP+G  KG G+S+ +D++A +
Sbjct: 186 RGKIIVAAQKGEDIPLGWAIDKHGNPTTNAQDALE-GSVLPLGGPKGYGISMFIDILAGV 244

Query: 240 LSDGASV---AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+          + ++ +D   +   F+AI+++  +   T   ++   +  + +  RA  
Sbjct: 245 LTGAGFGRYVNNMYENWNDPQNVGHFFLAIDINSFMPIETFKKRIDMYLREIKAEPRAIG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              I +PG   +  + E ++NGI +   V  +++ +
Sbjct: 305 VDKIYIPGEIESFKVKERKKNGIELPSKVVEELRLI 340


>UniRef50_Q58820 L-sulfolactate dehydrogenase n=12 Tax=Methanococcales
           RepID=COMC_METJA
          Length = 344

 Score =  379 bits (973), Expect = e-104,   Method: Composition-based stats.
 Identities = 91/335 (27%), Positives = 158/335 (47%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +  E  K     VL   GV  E A   A++F      G  SHG+ RFP++I  L+ G+
Sbjct: 1   MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGN 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P    K +    A    D    +G +  KK M+ AI+ A + G+G+VA RNANH+   
Sbjct: 61  INPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFS 179
           G Y   A  +  IGI  TN+   M P+G KE  +GTNP+ +A         +DM+ +  +
Sbjct: 121 GYYSELAMNQDMIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIA 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +        ++P     D +G  T +P    +   ILP G  KG G+++ ++M++  
Sbjct: 181 RGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALE-GCILPFGGPKGYGLALAIEMLSA- 238

Query: 240 LSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +       +V  T +  +      +FIAI  +  +       K+  ++D + ++E A+  
Sbjct: 239 IGGAEVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGF 298

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + I +PG        +  ++G  +D +++ +++ +
Sbjct: 299 E-ILIPGEIEERNKMKR-KDGFEIDKNLYNQLKEI 331


>UniRef50_C5CGX7 Malate dehydrogenase n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGX7_KOSOT
          Length = 352

 Score =  377 bits (968), Expect = e-103,   Method: Composition-based stats.
 Identities = 83/347 (23%), Positives = 158/347 (45%), Gaps = 18/347 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV  E+L      V+   G D E A   AE+       G+ SHGV R  R++  ++   
Sbjct: 1   MKVKREKLMNFTADVMKKMGCDDEKARVVAEVLVEADMRGISSHGVARLKRYVNHIKERI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ +P+ I         D    +G   AK  M++ IE A  +GIG+  +RN+NH+   
Sbjct: 61  IDPNGEPEIIFETPVTLAIDGNNGVGQHIAKFSMEKVIEKAKKYGIGMATVRNSNHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   A + G +GI  TN+  ++    ++E  +GTNP+  A P++     ++DM+ S+ 
Sbjct: 121 GYYAEMAVKMGLVGISLTNTAPLVVHTFSREALLGTNPIAFAFPTSEKYPILIDMATSVA 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGYWK 225
             G LEV     +++P     D+ G+ T +P  +  N                      K
Sbjct: 181 PRGKLEVYSRLNKKIPKGWAVDETGHTTTDPEKVLSNLKQRKGGGLLPLGGEGEEFSGHK 240

Query: 226 GSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIM 285
           G G+ ++++++ + LS G+   +  +       I+  F A++     +          ++
Sbjct: 241 GYGLVLLVELLTSGLSLGSFSYDTYKGKGK---ITHFFAALDPAIFGNPEKIKEHAMELI 297

Query: 286 DYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + + SA++AD  + I + G +      ++   G+ +D+  + +++ +
Sbjct: 298 NSLRSAKKADGKERIYVHGEKEYEKREKSLECGVEIDEPTYYELRKI 344


>UniRef50_D1CEH6 Malate/L-lactate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CEH6_THET1
          Length = 383

 Score =  376 bits (966), Expect = e-103,   Method: Composition-based stats.
 Identities = 87/349 (24%), Positives = 145/349 (41%), Gaps = 17/349 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V    LK+    V    GV  E AD  A++       G+ SHGV R  R+  +L  G 
Sbjct: 13  ISVDHMALKSWVTEVFCKLGVPREDADVTADVLVAADLRGIESHGVARLGRYTSRLMKGL 72

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A P  +    +    D    +G   A   M  AI+ A + G G VA+RN+NH+   
Sbjct: 73  ISPVANPVIVRETSSTALVDGNNGLGQPVAMWAMQLAIDKAREVGSGTVAVRNSNHYGIA 132

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   A E   IG+  TNS  ++ P G ++  IGTNP+ VAIP+      ++DM+ S+ 
Sbjct: 133 GYYAMMALEHDMIGMSLTNSSPLVVPTGGRKAVIGTNPIAVAIPAGKERPWVLDMATSVV 192

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILP------------MGYWKG 226
             G LEV     + +P+    D+ G  T +   +                       +KG
Sbjct: 193 PRGKLEVYARKNKPMPLGWAVDETGQPTTDAQRVLDALTARLGGGILPLGGTALFSGYKG 252

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRDAKLQR 283
             +S+++D++  +L       +V +          +   F A+ VD          ++  
Sbjct: 253 YNLSVMVDLLCGVLPGSNWGPKVDEPVDGKLVPSRVGHFFWALRVDAFRPIDEFKQEMDD 312

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  +  + +A+    I + G +   L  E  R G+ +   V   ++ +
Sbjct: 313 YIRMLKESPKAEGEDRIWVAGEKEWELQEEYSREGVPLYYKVVETLRGI 361


>UniRef50_B5I9V7 Malate/L-lactate dehydrogenase subfamily n=3 Tax=Aciduliprofundum
           boonei T469 RepID=B5I9V7_9EURY
          Length = 371

 Score =  373 bits (959), Expect = e-102,   Method: Composition-based stats.
 Identities = 80/343 (23%), Positives = 152/343 (44%), Gaps = 11/343 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+L      +     V  E A   A+        G+ SHGV R  R++  ++ G 
Sbjct: 19  VRIPREKLFNFVVEIFKRLDVPEEDAKIVADNLIMADMRGIESHGVQRLKRYVDGIKVGA 78

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +      K +         D   ++G +   K M  AIE A   G+G+V +RN+NH+   
Sbjct: 79  VNVHPNIKVVKESPVFAVLDGDEALGQVVGYKGMKMAIEKAKKVGVGIVGVRNSNHYGIA 138

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G Y + AA++  +G+  T S  ++   GA E  +GT+P+ VA P   +   ++DM+ S+ 
Sbjct: 139 GYYSYMAAKEDLVGVSMTTSRPLVAHTGAMEKFMGTSPISVAAPVEGSRPFLLDMATSVV 198

Query: 179 SYGMLEVNRLAGRQLPVDGGF-DDEGNLTKEPGVIEKN-RRILPM-------GYWKGSGM 229
             G +EV R   + +P D     + G +  +P  I      ILP+       G  KG G+
Sbjct: 199 PSGKIEVYRRKNKPVPGDWAISTETGEIIHDPNEILSPKGTILPLGGLGEISGGHKGYGL 258

Query: 230 SIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVT 289
             ++D++A +L+       V   +     +   F+AI+     D       +++ M+ + 
Sbjct: 259 GAIVDILAGILNGATWSKHVGGTSDKHSDVGHFFMAIDPGAFGDKEEFKKNMRKFMEELK 318

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +A++  + + I + G +         + G+ +   V  ++ A+
Sbjct: 319 NAKKHPKFERIWVHGEKGFLTYEAREKLGVPIYKKVLDEMNAI 361


>UniRef50_Q8EMJ6 Malate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EMJ6_OCEIH
          Length = 356

 Score =  371 bits (953), Expect = e-101,   Method: Composition-based stats.
 Identities = 86/335 (25%), Positives = 157/335 (46%), Gaps = 8/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ + L+     +L    +  E A+  AE        GV SHGV R   +++++E+G 
Sbjct: 4   IAVSEKDLQRFCRDLLKQS-LPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGI 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I        +    A    DA    G +   K M+ AI+ A  +G   V + N+NH+   
Sbjct: 63  IERKTDISVVQDSFATALLDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTA 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSM 177
             Y   AAEKG+IGI  TN+  +M P+GAKE  +G NP+ ++IP+       ++DMS S 
Sbjct: 123 SFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNPISISIPAGEGKKPIILDMSTSN 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G + V +     +P       +G  T +     +   +LPMG  KGSG++I++D+++
Sbjct: 183 VARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWE-GFVLPMG-PKGSGLAIIIDILS 240

Query: 238 TLLSDGASVAEVTQDNSDEYG--ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            +L+       + +   D Y   +  +F AI ++   +       +   ++   S+E ++
Sbjct: 241 GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSE 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
               + +PG   +    E + NGI +   +  +++
Sbjct: 301 GFDQVYMPGDMESQRKKEYKENGIPLSQEIINELR 335


>UniRef50_O34736 Uncharacterized oxidoreductase yjmC n=3 Tax=Bacillus
           RepID=YJMC_BACSU
          Length = 337

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 154/336 (45%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E+ K    + L   G++   A+  A++        V+SHGV     ++ +L  G 
Sbjct: 4   ITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLAGG 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQP    +       D     G++     MD AI++A   G+G+V   N++H    
Sbjct: 64  INPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
             +  +AA++  IG+  T++ +++ P+G +   +GTNP+   +P+      ++DM+ S  
Sbjct: 124 SYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPAKHKKPFILDMATSKV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R  G+++P   G D+ G    +P  +     +   G  KG G+SIV+D+ + 
Sbjct: 184 AFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV---SLSTFGGPKGYGLSIVVDVFSG 240

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LL+  A       +      +  +     AI      D  T   ++  ++D +  +  A 
Sbjct: 241 LLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFFTDWDTFLEQMDAMIDELQQSPPAV 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + + +PG         N++NGI++  SV+  +++
Sbjct: 301 GFERVYVPGEIEQLHEERNKKNGISIARSVYEFLKS 336


>UniRef50_D2LY27 Malate/L-lactate dehydrogenase n=1 Tax=Bacillus cellulosilyticus
           DSM 2522 RepID=D2LY27_BACS4
          Length = 367

 Score =  363 bits (933), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 70/335 (20%), Positives = 146/335 (43%), Gaps = 7/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +++L+    ++    G+    A   AE   +    G  SHGV R   ++++++ G I
Sbjct: 4   RFHWKRLETFCEKLFTKAGLPENDAKIVAESLVQADLQGTDSHGVVRADIYLRRIQAGMI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D + +       +   D +  IG++   + ++ AIE    HG   V ++ +NH+    
Sbjct: 64  NRDEEMEVHYDGP-VILLDGKNHIGSVVGNRALELAIEATKQHGTASVGVKGSNHFGTCS 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
            +  +A ++  I I  +N+   MPP G     +GTNPL +  P+      ++DM+ S+ +
Sbjct: 123 YFLQKAIKENIIMIIVSNASQTMPPTGGIRPFLGTNPLSIGAPAGRYAPFILDMATSVVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G+ +P +   D  GN T       +   +LPM   KG  +S+ +D+++ +
Sbjct: 183 RGKIISAAQKGKSIPKEWAIDKFGNPTTVAEDALE-GSVLPMAGPKGYAISMFIDILSGV 241

Query: 240 LSDGASV---AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+          + ++  D   +   +I IE+ K +       ++ +  D +    +A  
Sbjct: 242 LTGAGFGRYVNNMYENWEDPQNVGHFYIGIEISKFMPIEEFKNRIDQYFDEIKREPKAPN 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + I +PG        +   +GI +   V  +++ 
Sbjct: 302 VEEILIPGEIEHRCRIKKMTHGIELPPKVEDELKR 336


>UniRef50_C5CEA5 Malate/L-lactate dehydrogenase n=3 Tax=cellular organisms
           RepID=C5CEA5_KOSOT
          Length = 373

 Score =  362 bits (930), Expect = 9e-99,   Method: Composition-based stats.
 Identities = 82/349 (23%), Positives = 155/349 (44%), Gaps = 19/349 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRF-PRFIQQLENGDI 61
           + F+ L+     V  + GV  E A   A +     + G+ SHGV R  P ++++++ G  
Sbjct: 11  LDFDVLENFMVDVFKALGVPEEDAKIVANVLITADKQGIDSHGVGRLKPIYVERIQAGIQ 70

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P    + +         D    +G++   K M  AIE A  +G+G+VA+RN+ H+   G
Sbjct: 71  NPITNFEIVRESPTTAVVDGHNGMGHVIGYKAMKLAIEKAKKYGMGMVAVRNSTHYGIAG 130

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
            Y   A ++G IGI  TN+   + P    E  +GTNPL   +PS      ++D + S+  
Sbjct: 131 YYVQMAVDEGMIGITGTNARPSIAPTFGVEPMLGTNPLTFGMPSDEEFPFILDCATSVSQ 190

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-----RRILPMG-------YWKGS 227
            G +EV   AG+++P      ++G    +   I ++       ++P+G        +KG 
Sbjct: 191 RGKIEVYARAGKEIPEGWVIGEDGKTRTDTEQILEDLKKGKAALVPLGGIGEETAGYKGY 250

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSD----EYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           G + V+++++  L  G  +  +T  +       Y I   FIAI ++   +          
Sbjct: 251 GYATVVEILSAALQGGNFLKMLTGFDEQGNRVPYRIGHFFIAINIEAFTELENFKKTTGE 310

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I+  + ++++A   + I   G +      E +  G  ++  +  ++  L
Sbjct: 311 ILRALRNSKKAPGAERIYTAGEKEYLTWLERKDKGAPLNHVLREQLVQL 359


>UniRef50_C6Y337 Malate/L-lactate dehydrogenase n=1 Tax=Pedobacter heparinus DSM
           2366 RepID=C6Y337_PEDHD
          Length = 364

 Score =  361 bits (928), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 78/348 (22%), Positives = 146/348 (41%), Gaps = 16/348 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +  +  QL+    R     GV  + A   A++ A + E G+ SHG+ R   +   L    
Sbjct: 8   IHFSATQLREFSTRTFTYFGVPYDEAVLAADVLAYSDEHGIDSHGIARLKTYFDLLRAKK 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  + + +    ++   D    +G +   K M+ AI+ A  HG G V++ N NH+   
Sbjct: 68  INPRPELRMLRERASVATIDGDNGLGLVVGPKCMEIAIQKARLHGSGWVSVCNTNHYGAA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y   A +   IG+  TN+   + P+   E  +GTNP+ +A P    P  ++D + S  
Sbjct: 128 GYYPVMALKDDIIGLSMTNTTKGVAPFNGAEKMLGTNPIAIAFPGLKEPPVVIDFASSAV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIV 232
           +YG +E+      ++P+    D +GN T  P  + +   +LP+G        KG  ++ +
Sbjct: 188 AYGKVEIAGRMAEEMPLGWCIDKQGNPTTSPTDMMQGGALLPLGADKNGSGHKGYCLAAM 247

Query: 233 LDMIATLLSDGASVA--------EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           +DM++ +LS                  +     GI   F A+++D   D     + +   
Sbjct: 248 VDMLSAVLSGANWGPFTVPFAIDSAPTERQVGKGIGHFFGAMDIDGFRDVNEFKSNIDDW 307

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + +         + +PG           + GI +   V + ++ +
Sbjct: 308 IHTMRNTAPIPGTGGVLIPGDPEREAYTLRMKEGIPLHPEVVSSLKTI 355


>UniRef50_C7IP78 Malate/L-lactate dehydrogenase n=1 Tax=Thermoanaerobacter
           ethanolicus CCSD1 RepID=C7IP78_THEET
          Length = 349

 Score =  360 bits (925), Expect = 4e-98,   Method: Composition-based stats.
 Identities = 87/337 (25%), Positives = 152/337 (45%), Gaps = 9/337 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++LK     +    G     A   AE    +   G+ SHG++  P ++++ + G   
Sbjct: 5   VDAKKLKELEVEIFKKAGFKESDAKIIAENLIYSDLRGIESHGISNLPIYVKRAKLGLYN 64

Query: 63  PDAQPKRI---TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
                  +     +  +   D + ++G + A K ++  +  A   GI    + N NH   
Sbjct: 65  LSGDIDILNLDKDIP-LLLIDGKNNMGQVAAYKAVEPLVNKAKKSGIAAAFIGNTNHCGS 123

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMF 178
            G YG   A    I I  TN+ A M PWG K   +GTNPL + IP     + +DM+ S  
Sbjct: 124 LGYYGNMIANNDCIFIGMTNAPASMAPWGGKVKFVGTNPLCITIPYNGQVINLDMATSTV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V    G ++P +  FD  G  T +P    K   + P+G +KG G+++++D+I+ 
Sbjct: 184 AKGKIYVALSKGDKIPDNWAFDANGKPTTDPQEALK-GTLYPLGGYKGFGLAMLIDIISG 242

Query: 239 LLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LL+  +   EV            +  +FIAI +  L+     + K+   ++ + S  R+D
Sbjct: 243 LLTGSSWGPEVGSLHNTLDRGQDVGIVFIAINITDLMPIKEYNEKINCYIEKMKSVPRSD 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +N  I  PG      + E  +NGI ++D  + ++  L
Sbjct: 303 DNSEIMFPGEPELRKMEERLKNGIPINDKTYEEVIEL 339


>UniRef50_A1HMI4 Malate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1
           RepID=A1HMI4_9FIRM
          Length = 355

 Score =  360 bits (924), Expect = 4e-98,   Method: Composition-based stats.
 Identities = 81/336 (24%), Positives = 143/336 (42%), Gaps = 8/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  E L      +    GV  + +   AE       +GV SHGV+R P +++++    + 
Sbjct: 8   VKAECLLDYCASLFEKVGVPRDESYINAENLVDADLTGVESHGVSRMPIYLKRIRMNAVN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P    + ++   +    DA  S+G +   K M+ AIE A   GI  + ++N+NH+     
Sbjct: 68  PRCTLRTVSESPSTAVIDACNSMGAVVGVKTMELAIEKAKKTGISFIVVKNSNHYGTAAY 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           +   A +   IG   TN  A M PWG K+   GTNP  VA+P+      + DM+ S+ + 
Sbjct: 128 HAKIALKHNMIGFTATNGAARMAPWGGKDPFFGTNPFAVAVPAGKHLPIIADMATSVVAL 187

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN---RRILPMGYWKGSGMSIVLDMIA 237
           G + +       +P+    +  G  T  P  +         LP G  KGS +++++D++ 
Sbjct: 188 GKIILAAKKNLPIPLGWALNKFGEETTNPKEVFDGKVIGTPLPFGGPKGSAIALLIDVLT 247

Query: 238 TLLSDGASVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
            +L+         ++  D      IS +F AI V+  +      + +  ++  V     A
Sbjct: 248 GILAGSTFGPQIKDMYADFDQPTTISHLFGAINVEAFVPVSQFTSSIDELITMVKQVSPA 307

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
                I LPG        +    GI + ++V   ++
Sbjct: 308 KGVDEIFLPGEIELRKKEKRLAEGIPISEAVLEDLR 343


>UniRef50_Q97LJ4 Malate dehydrogenase n=1 Tax=Clostridium acetobutylicum
           RepID=Q97LJ4_CLOAB
          Length = 369

 Score =  360 bits (924), Expect = 5e-98,   Method: Composition-based stats.
 Identities = 90/344 (26%), Positives = 156/344 (45%), Gaps = 14/344 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K  +E L      V    G   E +    E+       G+ SHGV R   + + + NG I
Sbjct: 12  KYKYEGLLNLCLEVFQRLGYTKEDSYTIGEVLLLADLFGIESHGVQRLTLYYKGIRNGSI 71

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                   +         D    +G + +KK M+RAI+ A   GIG+  ++N+NH+   G
Sbjct: 72  KVKNHMNIVKESPVSVVIDGDGGMGQIISKKAMERAIDKAKKTGIGMAIVKNSNHFGIAG 131

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   A  KG +GI  TN+ A++ P   +E  +GTNP+ +A+P+ P   ++DM+ S+ + 
Sbjct: 132 YYSRMAERKGLMGIAMTNTRAIVLPTYGREQMLGTNPISIAMPARPIPFLLDMATSVITR 191

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK-----NRRILP-------MGYWKGSG 228
           G +EV     ++L      DDEG  T  P  + K        +LP        G  KG G
Sbjct: 192 GKVEVYSKNNQKLNYGWAMDDEGRKTDNPDKVLKLANGNTGGLLPLGGDTEIFGGHKGYG 251

Query: 229 MSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +S  ++M  ++LS G +  E+  +N+   G+   F AI+     D    + ++   M  +
Sbjct: 252 ISFAVEMFTSILSGGLTSDEIRGNNNT-NGVCHAFAAIDYGLFDDKNAIEKRMSAYMQKI 310

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            ++++A     I   G +      +   NGI ++++   +I+ +
Sbjct: 311 RNSKKAYGASRIYTHGEKELEAYEDRMENGIPINENTIVEIKEI 354


>UniRef50_A5N0Y5 Mdh n=5 Tax=Bacteria RepID=A5N0Y5_CLOK5
          Length = 369

 Score =  359 bits (922), Expect = 8e-98,   Method: Composition-based stats.
 Identities = 96/348 (27%), Positives = 165/348 (47%), Gaps = 20/348 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV +E LK   + V    G   E +    ++   +   G+ SHG+ R  ++  +++NG I
Sbjct: 5   KVKYEGLKKLCDIVFEKFGFSPEDSGTITDVLLLSDLFGIESHGIQRLVKYYSEIKNGLI 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D++PK I         DAQ  +G L  +K M+ AIE A   G+G+V +RN+NH+   G
Sbjct: 65  KVDSKPKIIKETPVSAILDAQAGMGQLAGRKAMNMAIEKAKTSGMGMVVVRNSNHYGIAG 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   A E+G +GI  TNS AV+ P   K+  +GTNP+ +++P+ P   ++D++ S+ + 
Sbjct: 125 YYAKMAEEEGLLGISMTNSPAVIIPTFGKDAMLGTNPIAISMPAKPYPFLMDIATSVVTR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILP----------------MGYW 224
           G +EV       LP+    D  G  T++P  I  N   LP                 G  
Sbjct: 185 GKIEVYNKRHEPLPLGLALDKNGEDTEDPYDILYN---LPKKLGGGLVPLGGSKELTGGH 241

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           KG G+++ +++   +LS G +   VT   S   G    F A++     D  + + KL   
Sbjct: 242 KGYGLALAVEIFTAILSGGITGNYVTLQGSSGSGTCHYFCAVDYSIFGDKNSIEDKLSEY 301

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ + ++++A     I   G +      +   NGI +++    +I  +
Sbjct: 302 LNELRNSKKAKGALRIYTHGEKEIESYKDKMENGIPMNEVTLKEIDEI 349


>UniRef50_UPI0001C34ECB putative malate/L-sulfolactate dehydrogenase n=1 Tax=Clostridium
           sp. M62/1 RepID=UPI0001C34ECB
          Length = 379

 Score =  359 bits (921), Expect = 9e-98,   Method: Composition-based stats.
 Identities = 92/337 (27%), Positives = 162/337 (48%), Gaps = 6/337 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V    L++    +    G++   A   AE   +T   G+ SHG  R P + +++ NG 
Sbjct: 29  VRVEAGYLESFVRELFEKAGMERGDAQFHAEALVQTDLWGISSHGCMRVPAYFERMRNGA 88

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I      ++++  GA E  DA    G +  K+ M+RA+ELA  + I  V +RN+NH+  G
Sbjct: 89  INVRPNVRKVSGEGAFEVLDADAGAGFIAGKRAMERAMELAKKYHIAAVGVRNSNHFGAG 148

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
             Y   AA++G  GI  TN + ++   GA     G NP+ VAIP        +DM++S  
Sbjct: 149 AVYARMAAKEGMAGIAMTNVLPLVTAPGASRPVTGNNPIAVAIPTYGDFPFCLDMALSKV 208

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L +    G ++P+D   D+EG  T +P    K   +LP+G +KG G++ V+D+++ 
Sbjct: 209 AGGKLTLAIKRGEKIPMDWATDEEGRPTDDPEKAFK-GFLLPVGGYKGLGLAYVVDILSG 267

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +++ G    +   +    ++       F+A+++D +ID      ++      +      +
Sbjct: 268 VVTGGVFSHQMKSMYAQPTEPSLTGHFFVAVDIDAVIDREQMKQRMGEYFRRIKETPMWE 327

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           E   + LPG        E R NGI V    + ++  L
Sbjct: 328 EGAEMLLPGELEYRKEKERRENGIPVPVKTYEELLEL 364


>UniRef50_C4Q0V1 Malate dehydrogenase, putative n=2 Tax=Schistosoma
           RepID=C4Q0V1_SCHMA
          Length = 384

 Score =  356 bits (914), Expect = 6e-97,   Method: Composition-based stats.
 Identities = 77/342 (22%), Positives = 158/342 (46%), Gaps = 14/342 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E++K    + L   G   + A A +++       G YSHG+NR   ++Q ++ G   
Sbjct: 30  ISTEEVKKFCIQCLQKVGAQLKHATALSDVLVAGDYRGHYSHGLNRLEMYVQDIQKGVCS 89

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +    +    D +  +G +     M+ AI+ A + GI  VA   +NH+   G 
Sbjct: 90  TDLEPTIVKETVSTALVDGKNVLGPVVGNFSMETAIKKANETGIAFVAAFGSNHFGIAGW 149

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMFS 179
           Y   A ++G IG+ +TN+  ++ P  A+   +GTNP+ +A P        ++DM+ S  +
Sbjct: 150 YSLMALQQGLIGLAFTNTSPLVFPTRARRLAVGTNPITLAAPGKVPEDHFVLDMATSAVA 209

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVL 233
            G +E++R  G ++P   G D +G  + +P ++     ++P+G       +KG G+ +++
Sbjct: 210 LGKIEMSRRRGIEIPKGWGADTDGKTSVDPNLVMTKGGLMPLGGEEENSGYKGYGLGMLV 269

Query: 234 DMIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++  +++D A    + +         + Q F+AI+      G   + +L   ++ + + 
Sbjct: 270 EILCGIIADAAFGPNIRRWLSTDKPANLGQSFLAIDPKAFAPG--FEQRLSEYVNIMRNL 327

Query: 292 ERADENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
              D  + + +PG      + E     GI     +   +  L
Sbjct: 328 PPVDNQKPVIVPGDFEREHMTECDELGGIPYPPVLIESLNRL 369


>UniRef50_D1C765 Malate/L-lactate dehydrogenase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C765_SPHTD
          Length = 355

 Score =  355 bits (911), Expect = 1e-96,   Method: Composition-based stats.
 Identities = 89/340 (26%), Positives = 158/340 (46%), Gaps = 8/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V    L+     VL+  G+  + A   AE+   +   G+ SHGV R   + ++L  G 
Sbjct: 6   VRVDAAVLQQFTADVLVGFGLSRDEAAITAEVLIASDIRGIDSHGVPRLGYYAERLRKGL 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I      + IT   A   +DA   +G+  A + M R IE A + G+ +  +R++NH+   
Sbjct: 66  INLTPNFRVITETPATIAFDADNGMGHPAAYRAMRRCIEKARETGLCMATVRHSNHFGIA 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
           G Y   A E+G  G+  TN+  ++ P  A+E  + T P+ VAIP+      +VD++ S  
Sbjct: 126 GYYAMMALEEGLCGVAMTNATPLVIPTFAREPYLSTAPIAVAIPAGRERPIVVDLATSTV 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE---KNRRILPMGYWKGSGMSIVLDM 235
           ++G +E+ R   + +P     D EGN+T +P              +G  KG  +++V+++
Sbjct: 186 AWGKIEIARREEKPIPWGWALDAEGNITTDPFAAVALTPLGATRELGSHKGYALALVVEV 245

Query: 236 IATLLSDGASVAEVTQD---NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   L+  A    V            I   F+A  +D         A++ +++  + +AE
Sbjct: 246 LCGQLAGAAWSRYVAGSRTVPPRPANIGHAFMAWRIDAFRPEEEFLAEIDQMLAELRAAE 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +    + +PG       A+ R NGI V   V A+++AL
Sbjct: 306 PVEGQPRVYVPGDPEDLAEADRRANGIPVHPKVLAELRAL 345


>UniRef50_B0VEY1 Malate dehydrogenase n=2 Tax=Bacteria RepID=B0VEY1_9BACT
          Length = 372

 Score =  354 bits (910), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 74/351 (21%), Positives = 147/351 (41%), Gaps = 19/351 (5%)

Query: 1   MK-VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG 59
           MK +  + L++    V I  GV  E A  C+++   +   G+ SHG+ R   +  +++ G
Sbjct: 10  MKYLPVDVLQSFMQEVFIKLGVPEEEAQICSDVLIASDLKGIESHGIGRLKMYYDRIKAG 69

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              P      +    A   WD    +G + +KK M  AI+ A  +G+G VA+RN+ H+  
Sbjct: 70  IQNPVTNIDVLRDKCATAVWDGNNGMGQVISKKAMQAAIDKAEKYGLGAVAVRNSTHFGI 129

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSM 177
            G Y   A  +  IG+ ++N+   + P       +GTNP+    P+      + D + S+
Sbjct: 130 CGYYAEMAIRQNMIGLVFSNARPSICPTNGVSPILGTNPICFGAPTDLPYPFLYDAATSI 189

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-----KNRRILPMGY-------WK 225
              G +E      ++ P+    D EG    +   +      +   +LP+G         K
Sbjct: 190 SQRGKVEQLAREEKETPLGWAIDLEGKPYTDTKGLLIDLLKQKAAMLPLGGTEEITGSHK 249

Query: 226 GSGMSIVLDMIATLLSDGASVAEVTQDN----SDEYGISQIFIAIEVDKLIDGPTRDAKL 281
           G G++  ++++   L  G  +  +  ++       Y +   F+AI ++   D        
Sbjct: 250 GYGLATAVEILCASLQKGNYLNGLLGEDENGKPAPYRLGHFFMAINIEFFTDLVDFKKIT 309

Query: 282 QRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I   + +++       I + G +   +  + R+ GI +  ++   I+ +
Sbjct: 310 TSICKDLQNSQLFPGKNRIYVAGEKEYEIEQKVRKQGIPIIPNLEKNIRII 360


>UniRef50_B4EV95 Ureidoglycolate dehydrogenase n=40 Tax=Bacteria RepID=B4EV95_PROMH
          Length = 349

 Score =  353 bits (907), Expect = 5e-96,   Method: Composition-based stats.
 Identities = 73/336 (21%), Positives = 143/336 (42%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M ++ +QL       L + G++   AD  A++       G++SHG  R   + +++  G 
Sbjct: 1   MIISKQQLHQLIKNKLHNAGLNENHADIVADVLVHADVKGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
                +     +      +D     G++ AK+ M+ AI +A + GI +V +R   H    
Sbjct: 61  TNTHPKFTYQETGPCSAIFDGDNGAGHVAAKQAMEHAINMAQEKGIAVVGVRRIGHSGAL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             +  QA+  G IGI    S  ++ P+G  E   GTNP+  + PS        DM+ ++ 
Sbjct: 121 SYFVEQASASGMIGISLCQSDPMVVPFGGSEVYYGTNPIAFSAPSADDKPITFDMATTVQ 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R     +P     D+ G  T +P  +   + +LP+   KG G+ +++D+++ 
Sbjct: 181 AWGKILDARAKHSDIPDTWAVDEAGKPTCDPFAV---KGLLPIAGPKGYGLMMMVDVLSG 237

Query: 239 LLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L        V     D +    + Q+ I I      D       + ++M  + S + A 
Sbjct: 238 ILLGLPFGKHVSSMYHDLTQGRELGQLHIVINPAFFTDADLFKKHISQVMAELKSIKPAV 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +  PG         + + GI + D ++  + +
Sbjct: 298 GFEQVLYPGENSQLAAQRSEKEGIEIVDEIYHYLNS 333


>UniRef50_A2R6I4 Catalytic activity: n=12 Tax=Leotiomyceta RepID=A2R6I4_ASPNC
          Length = 362

 Score =  353 bits (906), Expect = 5e-96,   Method: Composition-based stats.
 Identities = 84/322 (26%), Positives = 148/322 (45%), Gaps = 5/322 (1%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
             E+ K     +L+  G+ +E A + AE        GV +HG+ R P+++ ++ NG + P
Sbjct: 12  DPEKAKDFAAALLVKAGLMAEDARSMAECLVLADVRGVDTHGLARLPQYLDRVSNGRVNP 71

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
                       +   D     G + A + MD AI+ A  +GIG+V + ++NH+    +Y
Sbjct: 72  RPSINITQKTPVVAHLDGDNGFGFVVATRGMDEAIKRAEIYGIGMVTVNHSNHFGMAATY 131

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYG 181
             QA +   I + +TNS   MPP+G KE  +G +P     PS      ++DM+ S+ + G
Sbjct: 132 VLQALKANMISLVFTNSAKQMPPFGGKETLLGISPFAAGAPSNTEVPYILDMAPSVVAKG 191

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +      G  +P+    D +GN T +  V   N  + P+G  KGSG++I++D+++ +L+
Sbjct: 192 KIRRAARRGESIPLGWALDADGNPTTDANVAL-NGSMAPIGGPKGSGIAILMDIMSGVLA 250

Query: 242 DGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
                 +V     ++    +   FIAI+ D ++      A++  +   V     A     
Sbjct: 251 GAEFGGQVGDQYKDTKPQNVGHCFIAIKPDIIMSTDDFKARMDILAQRVHGVSPAPGFSE 310

Query: 300 IRLPGHEFTTLLAENRRNGITV 321
           +  PG     L  + R  GI  
Sbjct: 311 VLFPGEPEHRLGLQRRAEGIPY 332


>UniRef50_B9L199 Putative oxidoreductase protein n=1 Tax=Thermomicrobium roseum DSM
           5159 RepID=B9L199_THERP
          Length = 353

 Score =  353 bits (906), Expect = 6e-96,   Method: Composition-based stats.
 Identities = 84/344 (24%), Positives = 151/344 (43%), Gaps = 15/344 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+L+     V +  G+  E A   AE+       G  SHGV R   +++++E G 
Sbjct: 3   VRLPVEELQRFVTEVFLRTGLSEEDAAISAEILVAADVRGFDSHGVARLDYYVRRIEAGA 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +   +    A   +DA   +G  +A + M R IE A + G+ L  +R +NH+   
Sbjct: 63  VNLRPRFHAVAETPATIAFDADNGMGFPSAYRAMRRCIEKAQESGLCLATVRRSNHYGIA 122

Query: 121 GSYGWQAAE-KGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
           G Y   A E  G IG+  TN+  ++ P  A++  + T P+  AIP+      + D + S 
Sbjct: 123 GYYATMALEVPGMIGVSMTNATPLVVPPHARDAYLSTAPIAFAIPAGKERPLVFDGATST 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY------WKGSGMSI 231
            ++G +E+ R   + +P+    D EG  T +P        + P+G        KG  +++
Sbjct: 183 VAWGKIEIARRNRQPIPLGWALDAEGRPTTDPFAAR---FLTPLGAFPELRSHKGYALAL 239

Query: 232 VLDMIATLLSDGASVAEVTQDNS---DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +++++   L+ G     V    S           F+AI +D         A +  ++  +
Sbjct: 240 LVEVLCGQLAGGVWAKYVGGSRSETIGPSNTGHAFMAIRIDAFRPLEEFLADMDDMLGEL 299

Query: 289 TSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             A   D  + + +PG       AE R NGI V   V A ++ +
Sbjct: 300 RRARPTDGAERVLVPGDLEAETEAERRANGIPVHPEVLATLREI 343


>UniRef50_B6HAQ0 Pc16g13590 protein n=26 Tax=Leotiomyceta RepID=B6HAQ0_PENCW
          Length = 357

 Score =  352 bits (905), Expect = 7e-96,   Method: Composition-based stats.
 Identities = 82/333 (24%), Positives = 147/333 (44%), Gaps = 5/333 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +    L+    ++LI+     E A+  ++        GV +HG NR P +++++    +
Sbjct: 13  NINHTDLQNFVKQILIANKTSPEHAEIVSKCLVSADLRGVDTHGSNRIPSYMERIRQNAL 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A P       A+ Q DA    G + A + M  AI +A   GIG+V+++++NH+    
Sbjct: 73  DPSAVPTIRQVTPAVAQVDAHNGFGFVAAHEGMKLAISMAQIFGIGMVSVKHSNHFGMSA 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
               QA E   + + +TNS   +P WG KE  +G +P+    P+      ++DM+ S+ +
Sbjct: 133 WLVQQALEADMMSLVFTNSSPALPVWGGKEKLMGVSPIACGAPAGEGRPFILDMAPSIAA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G ++P D   D +G  T +P    +   +LPMG  KGS +S+++D+ + +
Sbjct: 193 RGKIYKALRRGEKIPTDWALDKDGAGTDDPAEALQ-GVMLPMGGPKGSALSVMMDVFSGV 251

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS  A    VT   D S    +    +AI+ D  +       ++  +   V  +E+    
Sbjct: 252 LSGSAFAGHVTNPYDPSKPADVGHFLVAIKPDLFMTIEEFKGRMDYLYQRVVDSEKMAGV 311

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             I  PG        +    GI    +    + 
Sbjct: 312 DRIYFPGEIEMITEEKRLAEGIPFATAEIESLN 344


>UniRef50_B8FR90 Malate/L-lactate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FR90_DESHD
          Length = 349

 Score =  352 bits (904), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 76/336 (22%), Positives = 144/336 (42%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L+    +   + GV         +        G+ SHGV+RFP ++++++ G +
Sbjct: 6   RYEVNTLRRFMEQAFTACGVSEADGQIVVDNLLYAELRGIKSHGVSRFPVYLRRIQMGAV 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P  Q         + + D    +G++     ++R +ELA   GI  V ++ +NH    G
Sbjct: 66  NPQPQISMEQRTPVLLKVDGDNGLGSVVMVHALNRGMELAEQLGICAVGIKGSNHCGASG 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
            Y   AAE+G + I  T+     PPWG ++   GTNP+   +P    P  +VD++ S+ +
Sbjct: 126 YYCELAAEQGLVSIVLTDGPPATPPWGGRKAYFGTNPMAFGLPRAQKPHIIVDLATSLAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G ++P     D EG  T +P        +LPM   KG  +S+V++ +A +
Sbjct: 186 RGKVIRAAAQGEKIPEGWALDREGLPTTDPQAAL-AGVLLPMAGAKGYALSLVVEHLAGV 244

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       +V     + +    +    I ++ D  ++      + ++ ++ +     A  
Sbjct: 245 LVGAGFGKDVAWQYSEGNKPANVGHFIILVKADAFMEMADYHKRTEQFVEEIKKIPLAPG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + I+LPG             GI +D  + A +Q +
Sbjct: 305 TKEIKLPGERSWEQQQNTEAQGIILDADLQAALQTI 340


>UniRef50_O27273 L-sulfolactate dehydrogenase n=6 Tax=Methanobacteriales
           RepID=COMC_METTH
          Length = 341

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 86/335 (25%), Positives = 155/335 (46%), Gaps = 10/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E+       +L +  V  E++D  A++       G  SHG+ RFP+++  L +G 
Sbjct: 1   MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D          +    +     G++ A + M+ AIE A + G+GLV + ++NH+   
Sbjct: 61  IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFS 179
           G Y   A     IG+   N+   + P G ++  +GTNP+ + IPS    + VDM+ S  +
Sbjct: 121 GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G L      G  +P +   D EG  T +P +  K   ILP G  KG  +S +++++A  
Sbjct: 181 RGKLLEAARKGESIPENVALDAEGKPTTDPEMALK-GSILPFGGHKGYALSFMIEILAGP 239

Query: 240 LSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L   A    V  T +  +      + +AI+  K++D     A++   ++ V S+      
Sbjct: 240 LVGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSS------ 293

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +PG   +  +   R  GI +D+ +  +I  +
Sbjct: 294 GDVLIPGDIESMNIKRRRAEGIELDEKLLERILGI 328


>UniRef50_A8RKJ3 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RKJ3_9CLOT
          Length = 349

 Score =  351 bits (902), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 91/332 (27%), Positives = 153/332 (46%), Gaps = 6/332 (1%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           E + A    +    G+    A   AE    T   G+ SHGV R P + +++ NG I  + 
Sbjct: 4   ETVTAFTQELFQKAGMSEPDAKYHAECLVNTNYWGIDSHGVIRVPAYFKRMLNGAINTNP 63

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           Q K +   G +E  D   + G +  +  M+RA++ AA  GI    + N+NH+  G  Y  
Sbjct: 64  QIKVVRGEGCLEVLDVDAAAGFIGGRAGMERAMDHAAVSGIAACGVINSNHFGAGALYAR 123

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGML 183
            AAE+G IGI  TN   ++   GA     G NP+   IP       ++DMS+S+ + G L
Sbjct: 124 MAAERGMIGIAMTNVKPLIVAPGASVPVTGNNPIAFGIPTYGEFPFVLDMSLSVVAGGKL 183

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
            +      ++P+D   D  G  T +P        +LPMG  KG G+S V+D+++ L++ G
Sbjct: 184 TLAIKKKEKIPMDWATDKNGRPTDDPQAAFD-GYLLPMGGHKGLGLSYVVDILSGLITGG 242

Query: 244 ASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
               +   +  +  D       FIA+++ K+I       ++ +  D + +     E   +
Sbjct: 243 VFSKDMKSMYANPKDPSLTGHFFIAMDISKIISKEQMKERMAQFKDQLKATPMWQEGAQM 302

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            LPG        E R+NG+ +  + + ++  L
Sbjct: 303 LLPGEIEYRKEQERRQNGLPIPVTTYEELAEL 334


>UniRef50_B8FVL5 Malate dehydrogenase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FVL5_DESHD
          Length = 351

 Score =  351 bits (902), Expect = 2e-95,   Method: Composition-based stats.
 Identities = 85/334 (25%), Positives = 161/334 (48%), Gaps = 6/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            + + +     R+L + GV +  A   + +   T+  G+ +HG++R P +++ L  G I 
Sbjct: 5   FSDQAMNDFCQRLLEASGVPATDAGIVSSILVDTSLEGIDTHGISRLPVYLKCLLKGRIN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P  + +  T   A+ + D    +G L A + M+ AI+LA  +GIG   ++N+NH+    +
Sbjct: 65  PKPKIQ-ETIDAAVARVDGDNGLGQLVAYRAMNSAIDLAKIYGIGFATVKNSNHFGAAST 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYG 181
           Y   AA +  IG  +TNS + +PPWG +    GTNP+    P      +VDMS S  + G
Sbjct: 124 YCKLAAAQQMIGQAYTNSPSGIPPWGGRAPYFGTNPISYGFPHAEYPVVVDMSSSTVARG 183

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            + +    G ++P     D +G  T       +   +LP+G  KG  +++  +++A ++S
Sbjct: 184 NIILAAKNGEEIPEGWAMDKDGKATTNAKAALE-GAVLPIGGAKGYTLALAAEVMAGIIS 242

Query: 242 DGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
             A  + V     +  +   I   F+AI + KL+       ++  ++  V +  +A+   
Sbjct: 243 GSAYGSHVGWIYDEGREPVNIGHSFLAINIAKLMPVEEFSQRMGDMIREVKAIPKAEGIT 302

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            IR+PG        + +++GI V + +  ++  L
Sbjct: 303 EIRIPGERRQANAEQRKQDGIPVAEGLLQELNML 336


>UniRef50_D1BPG4 Malate/L-lactate dehydrogenase n=14 Tax=Bacteria RepID=D1BPG4_VEIPT
          Length = 379

 Score =  350 bits (899), Expect = 4e-95,   Method: Composition-based stats.
 Identities = 85/346 (24%), Positives = 153/346 (44%), Gaps = 16/346 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +   +E LK          G   + AD   ++   +   G+ SHG+ R  R+ + + NG 
Sbjct: 8   VLFPYETLKKLSMDAFQKFGFSEKEADIIQDVLLTSDLFGIQSHGMQRMVRYHKGITNGL 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  DA+P+ +         D    +G L   K M+ AIE A   G+G+V++RN+NH+   
Sbjct: 68  IKIDAKPEIVKETPISAVIDGHDGMGQLLGHKAMEMAIEKAKKSGVGIVSVRNSNHYGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y   A+++G IG   TNS A+M P  A++  +G+NP+   +P+ P     D S ++ +
Sbjct: 128 GYYAKMASDQGLIGFSCTNSEAIMVPVYARKAMLGSNPIAWTVPADPVDFFFDCSTTVVT 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE------KNRRILP-------MGYWKG 226
            G LE+    G+  P     + +G  + +   +       +   ILP       +G  KG
Sbjct: 188 RGKLEMYNKMGKATPDGWAVNKDGVPSTDAAEVLGNISRHEGGGILPLGGATEVLGGHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
            G  ++ ++ +++LS G +  +       +  I   F+AI  +   D         + + 
Sbjct: 248 YGNGMIAELFSSILSQGGTSNKCMV--GGKSNICHGFMAINPEFFGDPAEIKKHFSQFLQ 305

Query: 287 YVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  A +A     I   G +    +A+ +  GI V +    ++Q L
Sbjct: 306 ELREAPKAQGQDRIYTHGEKEHESVAKVKAEGIPVLNGTMLEVQDL 351


>UniRef50_Q2LTF1 Malate/L-lactate dehydrogenase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LTF1_SYNAS
          Length = 373

 Score =  350 bits (898), Expect = 5e-95,   Method: Composition-based stats.
 Identities = 83/349 (23%), Positives = 161/349 (46%), Gaps = 19/349 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++L     ++  S GV  E A  CA+        G+ SHGV R  R++  + NG I+
Sbjct: 15  VNNQKLTQFVQKIFSSFGVTREDAVICADNLVLADLRGIPSHGVARLRRYVDGMSNGTIL 74

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P ++P  +    +    D Q  +G +        AIE A   G+G+VA+RN+NH+   G 
Sbjct: 75  PHSKPIIVREAPSTATVDGQAGLGQIVGHFSTQLAIEKARKTGVGIVAVRNSNHYGIAGY 134

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y     + G +GI  TN+  ++ P   ++  IGTNP+ +  P+       +DM+ S+   
Sbjct: 135 YTQMMLDAGLLGISMTNTAPLVVPTFGRKMIIGTNPISMTAPTRRNKPFFLDMATSVIPR 194

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGYWKGS 227
           G LEV    G+ +P     D +G    +   + +N                   G +KG 
Sbjct: 195 GKLEVYDRMGKDMPEGWAVDSKGQTATDATEVLRNMVARLGGGILPLGGEGELYGGYKGY 254

Query: 228 GMSIVLDMIATLLSDGASVA----EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           G+++++D++  +LS GA       +          ++  F+A+ ++  ++      K+  
Sbjct: 255 GIALLVDILCGVLSGGAYADLVDIKGPGGAGQPALVAHFFMALNIENFVEMEIFMEKMDD 314

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++D +  + +A+    I + G +   L  ++R+ G+ ++++V   ++A+
Sbjct: 315 LIDRLKESAKAEGQNRIYIHGEKEYELYEQHRQTGVPLEENVHETLKAI 363


>UniRef50_C3MH59 Malate/L-sulfolactate dehydrogenase n=2 Tax=Bacteria
           RepID=C3MH59_RHISN
          Length = 358

 Score =  349 bits (896), Expect = 9e-95,   Method: Composition-based stats.
 Identities = 85/332 (25%), Positives = 158/332 (47%), Gaps = 6/332 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            + ++L A   ++  + G+    A   A    +    G+ SHGV+R P ++++L+ G + 
Sbjct: 7   FSSDELIAFATKIFAATGMADADAATIAGDLVKANLRGIDSHGVSRIPMYVERLQRGLVN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P          GA+   D    +G + + +  + AIELA  +GIGLV +  + H+  G  
Sbjct: 67  PKPAVTVKKVAGAVSLVDGDNGMGFIASHRATEEAIELARANGIGLVGVHRSTHFGMGAL 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y  QA E GYI + +TNS   +P WG +   +G +P+   IP       ++DM+M++ + 
Sbjct: 127 YALQAIEAGYISMIFTNSSPAIPMWGGRTTFLGASPIAAGIPGGKYAPYVMDMAMTVIAR 186

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + +  + G  +      D +GN T +     +    LP G  KGS ++ ++D+++ +L
Sbjct: 187 GKIRLAAMKGETIAEGLALDVDGNPTTDAAKAFE-GVCLPFGGVKGSVLATLMDLMSGVL 245

Query: 241 SDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      +V     D+S+   +  +F AI+ D  +     DA++    + + +  +A   
Sbjct: 246 TGANFGGDVKSLYFDHSEPQNVGHLFFAIKPDLFMSPENFDARMDAFYERIKALPKAAGV 305

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           + I +PG       AE  R GI +  +V A +
Sbjct: 306 EEIMMPGEPEQRREAERLRTGIPITANVIADL 337


>UniRef50_Q8TYB0 L-sulfolactate dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TYB0_METKA
          Length = 341

 Score =  348 bits (893), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 92/336 (27%), Positives = 164/336 (48%), Gaps = 10/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  E L    +  L + GV  + A   AE+       G +SHGV R P +I+ ++ G 
Sbjct: 1   MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGA 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+ + + I+   ++  +DA  S+G++   +    A+ELA  HG+G+VA+RNA+H+   
Sbjct: 61  IRPEMRIEEISRKSSVVLYDADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y    AE+G+IG     +   + P+G  +  +GTNP+ +A P    P  +VDM+ S+ 
Sbjct: 121 GYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVSIAFPRRDGPPIVVDMATSVV 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +       R++P D     +G  T +P    +   +LP G  KG  + + L+++A 
Sbjct: 181 ARGKILQALRENREIPQDWAVGPDGEPTTDPEEALE-GALLPFGGHKGYALCLALEVLAG 239

Query: 239 LLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            +   A+  +V  T D +       +F+A+++  L+D      +L+R++  V SA     
Sbjct: 240 PVVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSA----- 294

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + LPG           R GI + +     ++ +
Sbjct: 295 GDDVLLPGEPEFRRRERALREGIELPEGSVRAVREV 330


>UniRef50_B0EJK3 Malate dehydrogenase, putative n=3 Tax=cellular organisms
           RepID=B0EJK3_ENTDI
          Length = 370

 Score =  346 bits (887), Expect = 8e-94,   Method: Composition-based stats.
 Identities = 76/349 (21%), Positives = 153/349 (43%), Gaps = 18/349 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFP-RFIQQLENGD 60
           ++ F++L+     VL+++GV+   A  CA++  +  + G+ +HG+ R    +  +++ G 
Sbjct: 8   RIHFDELEKFIKDVLMAKGVEEPDAARCAKVLIQADKQGMDTHGIQRLKTIYCDRIDCGQ 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +        +         D    +G+  A + M  AI+ A  HG+G+V +RN  H+   
Sbjct: 68  LNTKTVFDIVKETETTAVVDGHNGMGHSIAMQAMQLAIDKAKKHGMGMVVVRNGTHYGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   AA++G IG    N+   + P  + E ++GTNPL+ A PS       +D + S+ 
Sbjct: 128 GYYPQMAAQQGCIGFSGCNARPSVCPCWSVEPKLGTNPLVFAFPSDEGFPFCLDCATSIV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK------------NRRILPMGYWKG 226
             G +E+    G++       D  G +  EPG + +                  MG  KG
Sbjct: 188 QRGKIEMYAREGKKCQPGWVCDRSGKVLSEPGPMLEAFQKGTAACYPLGGYGEEMGGHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSD---EYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            G +  ++++++ LS    +++             + Q F+AI ++        + ++  
Sbjct: 248 YGYACDVEILSSALSGANFLSQCGGLRDGKKVPIELGQFFMAINIESFRPLADFEKQVGD 307

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I   + +A +A     I  PG +      E  + G+ + +   ++++ L
Sbjct: 308 IARELRAAAKAPGATRIYTPGEKEHETFLERSKKGVFIPEVTRSEMEKL 356


>UniRef50_C1XHB0 Malate/lactate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XHB0_MEIRU
          Length = 336

 Score =  344 bits (882), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 89/327 (27%), Positives = 158/327 (48%), Gaps = 6/327 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  +QL+    ++LI+RG   E A   AE        GV SHG+ R P ++++   G + 
Sbjct: 4   IPVQQLRERVEQILINRGFTLENALPIAESLVLAEMRGVASHGLIRLPIYLERARLGSVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+P  +    A+   DAQ   G  +  K M+ AIE A   G+  V +R ++H+     
Sbjct: 64  PQARPVLLADYPALALLDAQDGHGIPSGLKAMELAIEKAQKVGLAAVGVRRSSHFGLAWY 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           +   A EKG +G+  +N+ A++ PWGA+   +GTNPL V IP+   P   +DM+ S  ++
Sbjct: 124 FVRSAVEKGLVGVALSNADALVAPWGARSRFLGTNPLAVGIPAMEEPPIALDMATSEAAH 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + + +G+ +P++   D EG  T +P        +LP G  KGS +S+++D++   L
Sbjct: 184 GKILLAKSSGKTIPLNWALDAEGRPTDDPDRAL-AGALLPFGGPKGSAISLLIDVLCGPL 242

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                G  +A +  +     G+   F+A+      D      ++   +  V +   A+  
Sbjct: 243 VGALIGPEIAPLYTEPERPQGLGHFFMALNPGVFGDAEQFRKQVDAYIRRVRALPPAENV 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDS 324
             + LPG     L  +  + G+++   
Sbjct: 303 DRVLLPGEREWRLEQKALQEGVSLSPE 329


>UniRef50_Q1V2K0 Malate/L-sulfolactate dehydrogenase multifunction enzyme n=3
           Tax=Candidatus Pelagibacter RepID=Q1V2K0_PELUB
          Length = 336

 Score =  344 bits (882), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 79/331 (23%), Positives = 149/331 (45%), Gaps = 7/331 (2%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           +LK     + I   ++ + A  CAE        G  SHG++R   +  ++    I P A+
Sbjct: 5   KLKTIIKDIFIKYKLNKDHATICAEALINAELVGAPSHGLSRLKMYCDRISKKVINPKAK 64

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
            K      +I   D   SIG + A   +  AI  A   GIGLVA++N+ H+   G Y  Q
Sbjct: 65  IKVKKISQSIAHVDGNNSIGFVAADTAIKTAINNAKKTGIGLVAVKNSGHYGLSGYYAEQ 124

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLE 184
           A +KG + + +TN+   + P GA +   GTNP+    P+      ++D S+SM + G + 
Sbjct: 125 AVKKGLMVMVFTNAPPAVAPHGALKSLFGTNPICFGTPTGSKVPFILDTSISMINRGKIR 184

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           V    G ++P     D  G  T +P    +  ++ P+  ++GSG++ ++D+++ +L+ G 
Sbjct: 185 VAAREGTKIPEGVALDKFGKPTTDPKKALEGVQL-PIAGFRGSGLAWMVDILSGVLTGGN 243

Query: 245 SVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                 +   D S    I  +F  ++ +  +   + + +++  +  +    +    + I 
Sbjct: 244 HAGRVKDPFTDFSGPQNIGHLFFVLKPNLFVG-NSFNKRIKDNIKTIKKLPKIKGVKEIL 302

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            PG         N +  I +  +V   ++ L
Sbjct: 303 YPGQSKFNRFKSNLKKEINISKAVLKDLEYL 333


>UniRef50_Q01XF2 Malate dehydrogenase (NAD) n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01XF2_SOLUE
          Length = 344

 Score =  342 bits (878), Expect = 9e-93,   Method: Composition-based stats.
 Identities = 83/330 (25%), Positives = 165/330 (50%), Gaps = 6/330 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + L      +L   GV    A+        +   GV SHG+   P +I QL  G++ 
Sbjct: 4   ISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMD 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+ + I+  G+   +D Q ++G   A+     A+ +A ++G+ LV  R +NH+     
Sbjct: 64  AQAEGRVISESGSCLHFDGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGAAAW 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM 182
           +  +    G IGI   N+  ++PPW  +E R+GTNP+ +++P     ++DM+ +  + G 
Sbjct: 124 WAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPICMSVPG--PWLLDMATTTVAAGK 181

Query: 183 LEVNRLAGRQ-LPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
           +    L  +  +P    FD +G  T +     K   ++P+G +KGSG++++++++ ++LS
Sbjct: 182 IFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYK-GMLMPLGGYKGSGLAMMVEILCSVLS 240

Query: 242 DGASVAEVT--QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
            GA   EV   +       +SQ+++AI+V + +      A++++++  + S + A     
Sbjct: 241 GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTE 300

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           + + G     + AE R NGI +    W ++
Sbjct: 301 VMVAGDPEWRMEAERRENGIPIAGGNWDQL 330


>UniRef50_C4M213 Malate dehydrogenase, putative n=4 Tax=Entamoeba RepID=C4M213_ENTHI
          Length = 365

 Score =  340 bits (873), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 81/348 (23%), Positives = 148/348 (42%), Gaps = 17/348 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFP-RFIQQLENGD 60
            V+ + +K    +VL+  G D E A    +        G+ +HG+ RF   +I +++ G 
Sbjct: 8   NVSIDTIKEFMYQVLLKVGSDEENARMVRDTLIAADLRGMDTHGIQRFKTVYIDRIKKGM 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+P  I         D     G++     M  AIE A  +G+G+V +RN+ H+   
Sbjct: 68  INPTAKPSIIRETSTTCVLDGNNGFGHVNGTIGMKMAIEKAKKYGMGMVVVRNSTHFGIA 127

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G Y   AA++G IGIC TN+ + +      E  +GTNPL + IPS        D + S+ 
Sbjct: 128 GYYSLLAAQEGCIGICGTNARSSVAATFGDEPILGTNPLAIGIPSDEAFPYCFDGATSIS 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-----RRILPMGY-------WKG 226
             G  E     G+ +         G   ++P  + +N       + P+G         KG
Sbjct: 188 PTGRFEKYVRMGKTVDKSWASMKGGKPIEDPKELLENYPKGKAYLHPLGGSDEVSGSHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEV--TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
             +S  ++++++ LS    +  +   ++ S ++ +   FIAI V+   D       +  I
Sbjct: 248 YCLSEFVEIMSSCLSIANFLNHIEEEKEKSGKFSLGHFFIAINVECFRDLNEFKKNVGDI 307

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + + ++   +  I   G +      + R+ G  +      +++ L
Sbjct: 308 NRTLRNTDKLPGHDRIYTAGEKEYETEQKRRKFGDDLPLVTINEMKEL 355


>UniRef50_Q746L8 Dehydrogenase n=3 Tax=Bacteria RepID=Q746L8_THET2
          Length = 344

 Score =  340 bits (873), Expect = 4e-92,   Method: Composition-based stats.
 Identities = 79/336 (23%), Positives = 153/336 (45%), Gaps = 8/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+   + L A    +L   G D  +A A A         GV SHG+ R P ++++LE G 
Sbjct: 1   MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P          G +   D +   G   A K ++ A  LA  HG+G V +R + H+   
Sbjct: 61  VNPSPTLPLE-ERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMA 119

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y  + A+ G++ +  TN+   + P+G +E  +GTNPL  A P+    +V D++ S  +
Sbjct: 120 GLYAEKLAQAGFLALVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESA 179

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + + R  G ++P   G D EGN T +P  +     + P+G  KG  +++++++++ +
Sbjct: 180 MGKVFLAREKGERIPPSWGVDREGNPTDDPHRVY---ALRPLGGPKGYALALLVEVLSGV 236

Query: 240 LSDGASVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+          +  +      +    +A++  + +       ++  +   + +   A  
Sbjct: 237 LTGAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVGKEAFLERMGALWQALKATPPAPG 296

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ + LPG             G+ + + V A+++AL
Sbjct: 297 HEEVFLPGELEARRRERALAEGMALPERVVAELKAL 332


>UniRef50_P77555 Ureidoglycolate dehydrogenase n=89 Tax=Bacteria RepID=ALLD_ECOLI
          Length = 349

 Score =  340 bits (872), Expect = 5e-92,   Method: Composition-based stats.
 Identities = 75/334 (22%), Positives = 134/334 (40%), Gaps = 8/334 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L       L   G+  E A   AE+       G++SHG  R   + +++  G 
Sbjct: 1   MKISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
              + + +   +        A  + G + AK  M+ AI+ A  +G+ +V +    H    
Sbjct: 61  TNREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAI 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
             +  QAA  G+IGI    S  ++ P+G  E   GTNPL  A P     I   DM+ ++ 
Sbjct: 121 SYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATTVQ 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   R     +P     D  G  T +P  +     +LP    KG G+ +++D+++ 
Sbjct: 181 AWGKVLDARSRNMSIPDTWAVDKNGVPTTDPFAVH---ALLPAAGPKGYGLMMMIDVLSG 237

Query: 239 LLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L       +V     D      + Q+ I I  +           L + M  + +   A 
Sbjct: 238 VLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMRELNAITPAP 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
               +  PG +      +    GI + D ++  +
Sbjct: 298 GFNQVYYPGQDQDIKQRKAAVEGIEIVDDIYQYL 331


>UniRef50_Q11YA5 Malate dehydrogenase (NAD) n=8 Tax=Sphingobacteriales
           RepID=Q11YA5_CYTH3
          Length = 381

 Score =  339 bits (871), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 75/346 (21%), Positives = 136/346 (39%), Gaps = 17/346 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
             ++ L A    V ++ G   E A     +       GV SHGV R   +++  E G I 
Sbjct: 27  YPYKDLFAFTKNVFLAMGCPQEDAQVATTVLLSADLRGVDSHGVARLTGYVRLWEAGRIN 86

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                + +    +    D    +G + A   M  AI+ A   G G V+++N+NH+   G 
Sbjct: 87  AKPNVRIVHETPSTATVDGDGGLGLVVAPIAMQIAIDKAKQVGSGWVSVKNSNHYGIAGY 146

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           +   A E   IGI  TN+  ++ P  + +  +GTNP+ VAIP+   P  + D + +  + 
Sbjct: 147 HAMMALEHDMIGISMTNASPLVAPTNSLKRLLGTNPIAVAIPAKNEPPMVADFATTTAAN 206

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY------WKGSGMSIVLD 234
           G LE+ +      P+    D  G  T     ++    +LP+G        KG  +  ++D
Sbjct: 207 GKLEILQRKNLDAPLGWIQDKNGVTTPNAHELKDGGALLPLGGDREHGSHKGYCLGSIVD 266

Query: 235 MIATLLSDGASVAEVT--------QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
           + + +LS       V           +    GI   F A+ VD           +   + 
Sbjct: 267 IFSAVLSGANYGPWVPPFVSFLPVPSDPVGEGIGHFFGAMRVDAFRPADDFKTHMDNWIT 326

Query: 287 YVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              +A   +  + + +PG     +       G+ + + V   ++ +
Sbjct: 327 TFRNAPAVEG-EKVLIPGDPEREIQFSRLNEGVPLLEPVVKDLKEV 371


>UniRef50_B4SWL6 2,3-diketo-L-gulonate reductase n=106 Tax=Gammaproteobacteria
           RepID=DLGD_SALNS
          Length = 332

 Score =  339 bits (871), Expect = 7e-92,   Method: Composition-based stats.
 Identities = 297/332 (89%), Positives = 319/332 (96%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVTFE+LK AF RVL SR +  +TAD CAEMFARTTESGVYSHGVNRFPRFIQQL+NGD
Sbjct: 1   MKVTFEELKGAFYRVLRSRNIAEDTADKCAEMFARTTESGVYSHGVNRFPRFIQQLDNGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           IIPDA+P+R+TSLGAIEQWDAQR+IGNLTAKKMMDRAIELA+DHGIGLVALRNANHWMRG
Sbjct: 61  IIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY
Sbjct: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           GMLEVNRLAGR+LPVDGGFDD G LTKEPGVIEKNRRILPMGYWKGSG+SIVLDMIATLL
Sbjct: 181 GMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL 240

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           S+G+SVAEVTQ+NSDEYG+SQIFIAIEVDKLIDG TRDAKLQRIMD++T+AERAD+N AI
Sbjct: 241 SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAI 300

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           RLPGHEFT LL +NRR+GIT+DDSVWAKIQAL
Sbjct: 301 RLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL 332


>UniRef50_C0CT69 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CT69_9CLOT
          Length = 349

 Score =  339 bits (871), Expect = 7e-92,   Method: Composition-based stats.
 Identities = 82/331 (24%), Positives = 150/331 (45%), Gaps = 7/331 (2%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQP 67
           +KA  + +  + G +   A+  A+         VYSHG+ R   + +++ +  I  +  P
Sbjct: 1   MKAWISDIFRAEGFNGGEAELVADSLVDADARSVYSHGIQRVKLYTKRIMSDCINREGCP 60

Query: 68  KRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQA 127
             +    A    D   ++G    K  M+ AI+ A  +G+  V  R +NH+ R   Y   A
Sbjct: 61  VIVVDRDATAVVDGDNAMGQTVGKFCMELAIQKARQYGVSFVTARGSNHYGRCAYYTRMA 120

Query: 128 AEKGYIGICWT-NSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYGMLE 184
            E   IG   T     +M PWG  + R+G NP   AIP+      ++DM+MS+ + G ++
Sbjct: 121 LEYDMIGFSATIGGGNLMAPWGGTDSRVGNNPYSYAIPAFNHYPVVLDMAMSVVAKGKVD 180

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           V       +P     D  G  T +     K   + P+  +KGSGM+IV+ M+ +++S+GA
Sbjct: 181 VASKTHSPIPDTWALDQNGFPTTDAEEALK-GSLRPIADYKGSGMAIVIGMLCSVISNGA 239

Query: 245 SVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                  V  D        Q+F+A+++ ++ D      ++ R +D++ ++  A   + + 
Sbjct: 240 IGPTLKRVYGDFDGGLNKGQLFMAVDISRMTDVQVFKERMDRQIDFIKASPAAANTEEVY 299

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           LPG           ++GI     +  +I+ +
Sbjct: 300 LPGELEYRSFDRQMKDGIVYPVEIIQEIREI 330


>UniRef50_A6ULS2 Malate/L-lactate dehydrogenase n=1 Tax=Sinorhizobium medicae WSM419
           RepID=A6ULS2_SINMW
          Length = 348

 Score =  337 bits (866), Expect = 2e-91,   Method: Composition-based stats.
 Identities = 84/336 (25%), Positives = 149/336 (44%), Gaps = 6/336 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  E L+     VL + G+  + A   A+        GV SHGV R   ++ ++  G 
Sbjct: 5   VILEAEALRGFTEDVLKAAGMRPQPAATVADTLVYADLRGVSSHGVARLGSYLDRIRAGV 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  D Q + I    A    DA    G +     M+ AIE A   G  ++ + N+NH+   
Sbjct: 65  MEIDPQMRLIREAPASGLLDAGNGFGQIAGMTAMEIAIEKAKSAGSAVIGIANSNHFGVA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
             +  +A   G +GI  TNS   M  +  +   IGTNP+   IP+      ++DMS S+ 
Sbjct: 125 AYFAERATRAGMVGIVLTNSSPAMTAFNTRIPLIGTNPIAFGIPAGAERPIILDMSTSLV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +  L G+ +P+   +DD G  T++     K   + P+G  KG+G+S+++D++  
Sbjct: 185 ARGKIRLASLTGKPIPLGWAYDDRGLSTEDAHAALK-GSLAPIGGPKGAGLSLIIDLLTG 243

Query: 239 LLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +L+      EV    D S       + IA +V + I      + +  ++  + +   AD 
Sbjct: 244 VLTGTGLTGEVKNITDISGPSRTGHLMIAFDVSRFISPELFKSSVDSVVANIKAMPSADG 303

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + +PG           R+GI V   +   ++ L
Sbjct: 304 G-PVFMPGEMEAIGAERRARDGIGVPRDIVDTLRGL 338


>UniRef50_A9KQQ8 Malate/L-lactate dehydrogenase n=11 Tax=Bacteria RepID=A9KQQ8_CLOPH
          Length = 334

 Score =  337 bits (866), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 157/331 (47%), Positives = 209/331 (63%), Gaps = 2/331 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ ++ +   F RVLI  G   E A   A++FA  +  GVYSHGVNRFPR I  +E G 
Sbjct: 1   MRIQYDDMVKEFTRVLIKYGFSEEKAKLSAKLFADNSLDGVYSHGVNRFPRVISYIEKGY 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P+    +  + G +E+WD    +GNL A+  MDRAIEL+  HGIG +A++N NHWMRG
Sbjct: 61  IKPEQTAAKTEAFGCVERWDGNLGMGNLNAQICMDRAIELSRTHGIGCIAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G+YGWQAA  G IGICWTN++  MP WGAK+ RIG NP IVAIP  S    + D +MS F
Sbjct: 121 GAYGWQAANAGCIGICWTNTMPNMPAWGAKDRRIGNNPFIVAIPRSSGAHVVADCAMSQF 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           SYG +E  RL G++LP+ GG+D+   +T +P  IEK  RILPMGYWKGSG+SI  D+IAT
Sbjct: 181 SYGKVEEYRLNGKKLPIPGGYDENDEITNDPAAIEKTSRILPMGYWKGSGLSIAFDLIAT 240

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           +LS G SV E+ +   DE+ ISQ+ IAI+     D    D  +  ++D + ++    EN 
Sbjct: 241 VLSGGNSVTEIGKLGEDEFAISQVMIAIDPSHFNDVALTDELINNVLDDIKASVPVKENG 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           +I  PG        EN  +GI V + +W KI
Sbjct: 301 SIYYPGESSLNTRIENTEHGIPVQEEIWEKI 331


>UniRef50_C0DY92 Putative uncharacterized protein n=1 Tax=Eikenella corrodens ATCC
           23834 RepID=C0DY92_EIKCO
          Length = 358

 Score =  337 bits (865), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 80/345 (23%), Positives = 148/345 (42%), Gaps = 16/345 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K+    L+A       + G   + A    ++       GV +HG  R   + Q +  G +
Sbjct: 6   KIDAAALRAFTEAAFKAYGFVPDEAAQITDVLMAADLCGVDTHGSQRLEMYRQHINGGFV 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              AQP+ +         D   ++G L A+  M  AI+ A   GIG+V++RN+NH+    
Sbjct: 66  RIGAQPETVFETPVSAVVDGHAAMGQLVARYAMQIAIDKAKQSGIGMVSVRNSNHYGIAA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSY 180
            Y   AA +G +GI  TNS  ++ P   +   +GTNP+ VAIP++P    +D + S+ ++
Sbjct: 126 YYSSMAASQGLVGISMTNSFPIVVPTYGRTPMMGTNPIAVAIPASPTDFSLDAATSVVAF 185

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK------NRRILPMGY-------WKGS 227
           G  EV    G   P+    + +G    +P +I +         + P+G         KG 
Sbjct: 186 GKPEVYLKKGLTAPLGWAINSQGVDETDPQIIVECVRQGLGGGMYPLGGSSELFGSHKGY 245

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           G +++++  +  LS G +     +  +   GI   F A   +   D     +     +  
Sbjct: 246 GYAVLVEFFSACLSQGTTSNHTMK--NGHAGICHHFAAFNPEIFGDAQAIRSHFSAYLQE 303

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + +A   + I + G +      E +++GI +      +++ L
Sbjct: 304 LRESAKAAGQERIYIHGEKEAECCRERKQSGIPILPKTLDEMRRL 348


>UniRef50_A6C5R1 Ureidoglycolate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C5R1_9PLAN
          Length = 371

 Score =  335 bits (861), Expect = 1e-90,   Method: Composition-based stats.
 Identities = 79/335 (23%), Positives = 146/335 (43%), Gaps = 8/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E LK    ++L+   +    A   A+    +   G+ SHGV R P +++++    I 
Sbjct: 11  IEPESLKEFCYQLLLQANLTGHDAGLVADTLVESNLRGIDSHGVARLPHYLERIRQQSIQ 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P  + +      A+ + D    +G L   K  D A+ELA D G G V++ N++H      
Sbjct: 71  PRPEMQWEPLGDAVGRVDGDHGLGQLAMVKAADHAVELARDSGAGWVSICNSSHCGALAY 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           YG + AE G IG  +T+   ++ P GA E   GTNP+ +  P        +DM+ S+  +
Sbjct: 131 YGLRIAEAGMIGFAFTHVDPMVTPHGAAEPFCGTNPICMTAPGKEGKSLCLDMATSITPW 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +      G  +P D   D  G  T +P  +     + P G +KGSG+ +++D++  LL
Sbjct: 191 NTIANAATEGVSIPGDWALDANGRGTTDPNEVV---ALFPFGGFKGSGLGLMIDVLCALL 247

Query: 241 SDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                  +   +  D +    +  +  AI++ +  +  T   +++ ++    + +   E 
Sbjct: 248 GGAPIGPDIPKMYGDLTQRRLLGGMVGAIDISRFTEVETFQDRIEELIQRWGAVKPLKEG 307

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  PG        E  ++GI V   +  +   L
Sbjct: 308 GKVYYPGEPEALTRVERLQSGIPVGLRLINQFNEL 342


>UniRef50_C0R1X7 Malate/L-lactate dehydrogenase n=2 Tax=Brachyspira
           RepID=C0R1X7_BRAHW
          Length = 334

 Score =  334 bits (858), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 72/333 (21%), Positives = 139/333 (41%), Gaps = 7/333 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +KV  ++L  A        GV +E A    ++       G++SHGV R   +I ++++G 
Sbjct: 2   IKVNVKELMDAVYNKFKMAGVSNEQAGIVTDVLIYADIRGIHSHGVLRVEHYIDRIKSGG 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +++        +    DA    G++  +  M+ A+E     GI L+ ++N +H    
Sbjct: 62  INLNSEFHIEEKRPSFALMDADGGFGHVATQYAMEWALETVEKQGIALIGIKNNSHAGAL 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMV-DMSMSMFS 179
           G Y   A ++  + +   N+   + P+G K    GTNP+    P     ++ DM+ S  S
Sbjct: 122 GYYNKMAIDQNKVSLIMVNTDPCVIPFGGKRSFFGTNPISYGFPGKKDFILGDMATSEVS 181

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R     +P+  G D+ GN +  P  I   + ++P G  KG  +  +++    L
Sbjct: 182 LGRIFTARENNETVPMHWGVDENGNPSSNPNEI---KYVVPFGGVKGYLIMTMVEAFTGL 238

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       ++ ++  D   +  +S   + ++     D  T    +Q  +D +       E
Sbjct: 239 LIGQVYCNNLVKMYGDMDKKRNLSTFMLVVDPAVYNDLDTYLNTVQSFIDDIRKEPALKE 298

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              I +PG           + GI + + ++  I
Sbjct: 299 GSTISIPGERKEACSKVYLKEGIPLPEHIYKYI 331


>UniRef50_C3ZIE6 Putative uncharacterized protein n=4 Tax=Coelomata
           RepID=C3ZIE6_BRAFL
          Length = 360

 Score =  334 bits (857), Expect = 3e-90,   Method: Composition-based stats.
 Identities = 81/338 (23%), Positives = 155/338 (45%), Gaps = 13/338 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  +++ A   R + + G     A A A+        G +SHG+NR   ++Q + +G  +
Sbjct: 11  VPKQEVIAFVERCMGAVGTPGAHASALAQALMTADYRGHFSHGLNRLDMYVQDIRSGMTV 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +         +    +G + +   MD A+  A D GIG V    +NH+   G 
Sbjct: 71  KDGEPTIVNERAGTAFVNGNNLLGPVVSNFCMDLAMRKAKDAGIGWVVACGSNHYSIAGY 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y  +A ++G +G+ +TN+  ++ P  A++  +GTNP+ VA P       ++DM+ S  + 
Sbjct: 131 YSLKACDQGLVGMSFTNTSPLVVPTRARKGVLGTNPISVAAPGKEGDSFVLDMATSTCAL 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLD 234
           G +E++   G  +P+  G D  G  T +P  + +    + +      G +KG G++++++
Sbjct: 191 GKIELHDRKGLPIPIGWGVDSAGRETTDPKAVLQGGGQMALGGSEVTGGYKGYGLAMMVE 250

Query: 235 MIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   +LS GA    V +   N     + Q F+AI+ +    G     ++Q +MD   + E
Sbjct: 251 LFCVILSGGAFGPNVRRWKTNDRVANLGQCFVAIDPEAFAPG--FHDRMQDMMDCCRNLE 308

Query: 293 RADENQAIRLPGHEFTTLLAENRRN-GITVDDSVWAKI 329
            A+    + + G      +A      GI    + +  +
Sbjct: 309 PAEGETEVLVAGDPERKHMAMCDAQGGIPYHVNQFTHL 346


>UniRef50_Q89D62 Blr7581 protein n=2 Tax=Rhizobiales RepID=Q89D62_BRAJA
          Length = 350

 Score =  334 bits (857), Expect = 3e-90,   Method: Composition-based stats.
 Identities = 85/338 (25%), Positives = 142/338 (42%), Gaps = 12/338 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++L      +L + G   E ADA A        +G  SHGV   P +I +++ G I+
Sbjct: 4   VRADRLTRISAALLQAAGASQEEADAVATGCVNANLAGHDSHGVIAVPTYIDRIKAGHIV 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A    I         D     G     K M   IE A    +    +   +H  R  +
Sbjct: 64  PGATWTIIQESPTTTVIDGHWGFGFHVNAKAMALTIEKAKTANVAACTVFRQSHVGRLAA 123

Query: 123 YGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSM 177
           Y   A  +G IGI   +   S   + P+G KE R+GTNP+ +A+PS       +DM+ S 
Sbjct: 124 YPLMAMREGMIGIATADSGRSPKHVAPFGGKEARLGTNPISIAVPSDLDAPFYLDMATSA 183

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG---YWKGSGMSIVLD 234
            + G +++    G ++P     D EG  T +P    K   +LP+G    +KGSG++ +++
Sbjct: 184 VAAGKIQLAVARGDKIPTGWIIDAEGRHTNDPTQYRKGGALLPLGGTEGYKGSGLAAMVE 243

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           ++  LL+      E     +  +          V           ++     Y+ S   +
Sbjct: 244 VLCGLLTGLGFGVE----PTGRHNDGCFMAVFNVAAFRPLKEFKREVAEFARYLKSTPPS 299

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +  +  PG        +  R+GI V+D+ W K++AL
Sbjct: 300 EGSTGVYYPGEIEGVREQQRLRDGIEVEDATWDKLRAL 337


>UniRef50_Q9XBD3 Putative carboxylic acid dehydrogenase n=1 Tax=Amycolatopsis
           orientalis RepID=Q9XBD3_AMYOR
          Length = 337

 Score =  330 bits (847), Expect = 4e-89,   Method: Composition-based stats.
 Identities = 86/335 (25%), Positives = 151/335 (45%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L+A   R+L++ G  +  A+  A     +   G  SHGV R   +++++  G 
Sbjct: 1   MNVQAAELEALATRILVAAGSSTVDAETVARSLVGSDLLGHDSHGVRRVIDYVKRIHTGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A+PK  T+         +R+ G L  ++ +   + L    G G+  +R  NH  R 
Sbjct: 61  IDPRAEPKAETTRPGTVVVHGRRAFGQLAVRRAVRELLSLVPHQGSGVAVVRECNHIGRL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI---PSTPITMVDMSMSM 177
           G Y    A++  IG+ + N+   + P+G +E R+GTNPL  A+   P  P  ++D + S 
Sbjct: 121 GEYVAMLADQDLIGLAFGNADPTVAPYGGRERRLGTNPLAWAVPRGPGQPPIVMDWATSG 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            + G L V R  G Q+      D  G  +  P    +   +LP G  KG G+S++++++ 
Sbjct: 181 IAEGKLRVARDRGEQVAEGLVLDAAGRPSTTPADFYQGGALLPFGGHKGYGLSVLIEIVG 240

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L     S   +        G   + +A ++   +  P   A+ +R    +     A+  
Sbjct: 241 GL----LSGIGIGSMPGFREGWGTVLVAFDIAAFLPVPEFRAQTERFCQALAETPLAEGA 296

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +PG     +  E  R+GI V  + W ++ AL
Sbjct: 297 SEVLVPGEPEERIRLERARDGIPVTANTWRELNAL 331


>UniRef50_D0RN53 Malate/L-sulfolactate dehydrogenase ((R)-2-hydroxyacid
           dehydrogenase) n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RN53_9RICK
          Length = 349

 Score =  330 bits (847), Expect = 4e-89,   Method: Composition-based stats.
 Identities = 82/337 (24%), Positives = 150/337 (44%), Gaps = 7/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           K+   +LK+    +L   G++S  A   +EM  R  E GV+SHG+ R P ++Q+L     
Sbjct: 4   KIKIYKLKSLTQAILKKVGLNSINAKVVSEMLVRADERGVWSHGIVRLPVYVQRLNKNAA 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P  + K      +    +    +G ++A + M + I+LA  +GIGLV + N+NH+    
Sbjct: 64  NPKPKLKFKKISQSAFHLNGDNGLGFISANEGMKKCIQLAKKNGIGLVGISNSNHFGMAA 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSMSMF 178
           +Y   AA+   I   +TN+   +PP GA     GT+P   + P+       ++DM+ S  
Sbjct: 124 NYLELAAKNNCISWVFTNASKALPPHGAMAPFFGTSPFAFSCPTKNKNKPFILDMASSSV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L+       ++P     D  G  T +     +   +LP G  KG+G+S ++D++A 
Sbjct: 184 ARGKLKFAAQNNIKIPFGYALDKFGKPTNDGQKAFE-GIMLPFGGMKGAGLSWMMDIVAG 242

Query: 239 LLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           + +      +V     D S    +  + I +  +          K++  +  V   ++A 
Sbjct: 243 IFTGANHSGKVKNAINDFSGPANVGHLMICMRTNLFQSHKNFIKKIEYGIKQVKQLKKAK 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + I  PG          +R+GI +      +++ L
Sbjct: 303 GFKKILHPGEPEYLNEMRLKRSGINLSKETVIELKKL 339


>UniRef50_Q1YDL3 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YDL3_MOBAS
          Length = 352

 Score =  330 bits (846), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 73/336 (21%), Positives = 143/336 (42%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +   L+   N +  + G+  + A    ++       G  SHG+ R P + +++  G +
Sbjct: 3   RFSLATLRPFANALFEASGLSQDHAALVTDVLIHADLRGHGSHGLTRIPIYAERIAAGAV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                 +      A  Q D     G + +   ++ AI  A + G+ + A+  +NH   G 
Sbjct: 63  NARPDIRFERPAPAFLQVDGDNGPGPVVSDAAVEAAIATAKEQGVCVAAVARSNHNGSGS 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
            Y  +A   G I +  TN+   M  +G ++  IGTNP+    P       M+DM+ S+ +
Sbjct: 123 FYVEKAVAAGCIALAMTNAPPSMAVFGGRQAVIGTNPVTFGTPVDGGTPIMMDMATSVVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G  +P     D +G  T +    E+   +LP+   KGS ++I+++++  +
Sbjct: 183 RGKVVEAAKRGEAIPEGWALDADGKPTCDGRAAER-GVVLPLSGPKGSALAIMVEVLCGV 241

Query: 240 LSDGASV---AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           LS G        +  D      I    + I+V ++       A+++ ++  +  +  A+ 
Sbjct: 242 LSGGRFAGSLGNLYSDFETPQDIGHFMLLIDVSRIHASSGYAARVRDLVLELKDSATAEG 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              I++PG         N   GI + D+V A + A+
Sbjct: 302 FSEIKMPGEVEMERARSNSAEGIDLPDNVVADLNAI 337


>UniRef50_C5RAQ8 Malate dehydrogenase n=1 Tax=Weissella paramesenteroides ATCC 33313
           RepID=C5RAQ8_WEIPA
          Length = 363

 Score =  329 bits (844), Expect = 9e-89,   Method: Composition-based stats.
 Identities = 89/348 (25%), Positives = 151/348 (43%), Gaps = 19/348 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   +++ A  N++  + G   E +   A+    T   G+ SHGV R   + + ++NG I
Sbjct: 4   RYDSQKMNALVNKIYQAYGFSKENSQKIADALIYTDLHGITSHGVQRLALYDRFIQNGKI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D+ P+           DA    G L     M  AIE A  HG+G+V  + + H+   G
Sbjct: 64  RIDSHPEIEKETDVSAVIDANFGSGQLNGMYSMGVAIEKAKAHGVGIVTTKRSGHYGIAG 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFSY 180
            Y   AAE+G IG+   NS   M P  AK+  IGTNP+  A+P+ P   + D + ++   
Sbjct: 124 YYANLAAEQGLIGMSSCNSRPGMIPTNAKKAFIGTNPIAFAMPAKPHNFIFDAATTVVPQ 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLT------------KEPGV----IEKNRRILPMGYW 224
           G +EV R   + LP      +                 ++P                G  
Sbjct: 184 GKIEVYRKQEKDLPALWVAKEGNQPVYDHTDTATLDSLRDPEANVGIAPLGGITEETGGH 243

Query: 225 KGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           KG G+ I++++  ++LS G + AE++  +  E G  Q FIAI+     D      K  R 
Sbjct: 244 KGYGLGIMVEVFTSILSLGNTSAEISA-SDVETGPCQSFIAIDPAIFGDSEKIIDKFSRY 302

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++ +         + + + G +      + ++NGI +DD    +I+A+
Sbjct: 303 LEDLRQLTAVPG-KEVYVHGDKEQLAYQDRKKNGIEIDDKTIMEIKAI 349


>UniRef50_B0PC96 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PC96_9FIRM
          Length = 353

 Score =  327 bits (838), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 93/337 (27%), Positives = 148/337 (43%), Gaps = 7/337 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E LKA     L   G++S  A  CAE  A T   G +SHG      +I++   G + 
Sbjct: 5   IALEDLKAFCTAALEHEGMESGDARRCAEALAETDAYGTHSHGTKNLHNYIKKFRAGGMD 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A  K +T   A    DAQ  +G   + + M+ AIE A   G+ LV +  +NH+   G 
Sbjct: 65  IHAALKVLTDGPAYALLDAQNGMGECASYRAMELAIEKARKSGVALVTVCRSNHFGAAGF 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFSY 180
           Y   AA+ G +G+C +N    M   GAK   +G NPL  A P+   P   +D++MS  + 
Sbjct: 125 YANMAAKAGMLGLCVSNVDPNMTAPGAKGMLLGNNPLAYAAPAKSTPSIFLDIAMSNVAS 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +   R  GRQ+P     D +G  T +P    +   + PM   KG G+SI++D++   L
Sbjct: 185 LKVVQARKDGRQIPDSWIVDKDGLPTTDPSHYPEEGAMQPMAAHKGYGLSILVDLLTGAL 244

Query: 241 SDGASVAEVTQ-----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           ++ A+           +      +S  F+ +  +          + +++   +  A +A 
Sbjct: 245 ANAATSMSGEIVSWCFELDKPNNVSHAFLVVNPEMFGGAQAYVQQNEQMAAALRKAPKAQ 304

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  I  PG       A     GI + D V   I+AL
Sbjct: 305 GSTRIYTPGEIEWERYARAVSEGIKLPDDVAGSIEAL 341


>UniRef50_A7VWV3 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VWV3_9CLOT
          Length = 410

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 79/340 (23%), Positives = 153/340 (45%), Gaps = 9/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V  ++ +A  +++  + G + + AD  A+        G  SHG+NR P + Q+LE+G 
Sbjct: 55  IIVPEKESQAYVSKLFQTIGAEKKHADVVADHLTMAEMRGQASHGLNRIPFYTQKLEHGG 114

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
              +   K +     +   DA  ++G ++    M+  +E A+  G   VA+ ++NH    
Sbjct: 115 YKANPHMKILREDAGVALLDADDALGAVSCSHAMELCMEKASRTGCASVAVTHSNHIGFL 174

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             Y   AA++  IGI   NS +    WG +E  +GT+P  + +P+      ++D + S+ 
Sbjct: 175 AYYTMMAAKRNMIGIAVCNSGSSTAVWGTRERVLGTDPFSIGVPAKKHFPVILDCATSVV 234

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V     + +P +  ++  G  T           + P G +KGSG++IV+ +I  
Sbjct: 235 AQGKVSVAETENKPIPGNWAYNKNGEPTTVASEAMV-GTMRPFGDYKGSGIAIVISLICA 293

Query: 239 LLSDGASVAEVT-----QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
            L+      E        D S    ++   IAI++ K  D      ++   +D V S + 
Sbjct: 294 GLTGMPFDFEEENLRRISDLSAGSELAASLIAIDISKFTDAEAFKHRVDGFIDVVKSFKL 353

Query: 294 ADENQAIRLPGHEFT-TLLAENRRNGITVDDSVWAKIQAL 332
           A + + I +PG      + A     G  +  +++ K++ +
Sbjct: 354 APDTEQIYMPGEIEFNKVAANRAAGGFEIGPNLYQKLKNI 393


>UniRef50_B7RGK0 L-lactate dehydrogenase n=1 Tax=Roseobacter sp. GAI101
           RepID=B7RGK0_9RHOB
          Length = 361

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 95/339 (28%), Positives = 155/339 (45%), Gaps = 9/339 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L A    +LI  G   + A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MKISAEHLTALATSILIHAGGQPDAAQRIATRLVSANLTGHDSHGVGMIPAYVDGIFAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PDA    +   G     D QR  G++ A++ MD AI+ A  +   +++LRN+ H  R 
Sbjct: 61  LDPDASVDVVQDKGPFLLVDGQRGFGHIVAEQAMDLAIQRARTNHFAVLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMS 174
           G +G  AAE G+I I + N   S  ++ P+G  + R  TNP   AIP+    P+ ++DM+
Sbjct: 121 GDWGAMAAEAGFICILYANVQSSRPLVAPFGGSDGRFVTNPYCTAIPATDTHPMFLLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMGYWKGSGMSIV 232
            S  + G   V  L+G+Q+P     D +GN T +P V+       +   G  KG G++++
Sbjct: 181 TSKIAMGKARVAHLSGKQVPEGSLIDAQGNPTTDPSVMFDDAGGALTTFGDHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            D++    S G +     +        + + I I+ D           + R  D+V ++ 
Sbjct: 241 GDILGGSFSGGGAYLPEREVPLSITN-NMLAILIDPDVFGMAQAFGVDMDRYTDWVKASP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A    A++LPG        + + NGI VD    A +  
Sbjct: 300 PAPGVDAVQLPGDPERRSAQDRQANGIFVDAGTRAHLVE 338


>UniRef50_C6VNL4 Malate/lactate dehydrogenase n=12 Tax=Lactobacillus
           RepID=C6VNL4_LACPJ
          Length = 362

 Score =  326 bits (836), Expect = 8e-88,   Method: Composition-based stats.
 Identities = 77/352 (21%), Positives = 152/352 (43%), Gaps = 24/352 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ E  +     V  ++   ++     A+        G+ SHG+ R   + + +++  
Sbjct: 1   MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  QPK +         DA +S+G + +   M++ IE     G+ L  +RN+NH+   
Sbjct: 61  LEPTNQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y   A + G IGI  TN+  ++ P  A E  +G+N L    P+ P   + D + ++ S
Sbjct: 121 GYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI------------EKNRRILPMGY---- 223
            G ++V    G Q+P D   D+   +  +   +                 +L +G     
Sbjct: 181 SGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLAKIAFSENRPGGGVLTLGGQQEV 240

Query: 224 ---WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S++++++  +L+ G+  A+    N+ ++  SQ F+ I      D     A 
Sbjct: 241 NSNYKGFGNSLIIELLTGILAQGSLSADT---NTGKHDFSQFFMTINPALFGDPEVLKAN 297

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + D +   +     + I +PG        EN   G+++D     ++Q +
Sbjct: 298 VTTMFDRIRHLKHLPGTK-IMIPGDREYRHYDENLVQGVSIDPQTLTEMQQV 348


>UniRef50_C9M4P7 Malate/lactate dehydrogenase n=5 Tax=Lactobacillus
           RepID=C9M4P7_LACHE
          Length = 361

 Score =  326 bits (836), Expect = 8e-88,   Method: Composition-based stats.
 Identities = 73/352 (20%), Positives = 143/352 (40%), Gaps = 23/352 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++    K    +V  +R          A+        G+ SHG+ R   +   ++   
Sbjct: 1   MRISSLSEKEFLEKVFAARQFSKSDGALLADTLVDADLRGISSHGIQRLAWYTSMIKEHI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  + K I         DA +++G +       + I+     G+ +  +RN+NH+   
Sbjct: 61  IEPQNKLKVIKETPTSLLIDANKNMGQIATAFAEKQLIKKTQKLGLSVAVIRNSNHFGTA 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G Y   AA++G IGI  TN+  ++ P  A E  +G+N      P+ P   + D + S+ S
Sbjct: 121 GYYARMAAKQGLIGIALTNTRPLVVPPNATEAFLGSNAFAFTFPAEPHPFVFDGATSIVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY---------------- 223
            G ++V     + +P D   DD   +  +   +E N   +                    
Sbjct: 181 SGKIQVLAKNNQPIPGDWAVDDHRRVMHDAQKVEDNLAKVAFTEKQPGGGVLTLGGLLQS 240

Query: 224 ---WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
              +KG G S+V++++  +L+ G+  A+  +     +  SQ  + I  +   +       
Sbjct: 241 NSNYKGFGNSLVVELLTGILAQGSISADTNK--PGHHDFSQFLLTINPELFGNLDDLKKS 298

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + + D +   +     + I +PG       AEN + G+ +DD   A+++ +
Sbjct: 299 AEEMFDRLRHLKHLPGTE-IMIPGDREYRRYAENLKQGVVIDDKTVAELKTI 349


>UniRef50_C7RGK9 Malate/L-lactate dehydrogenase n=1 Tax=Anaerococcus prevotii DSM
           20548 RepID=C7RGK9_ANAPD
          Length = 337

 Score =  325 bits (835), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 135/334 (40%), Positives = 205/334 (61%), Gaps = 2/334 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKVT+++LK      L + GV  E ++  A++ A +T  GV SHG+NR PR I  +  G 
Sbjct: 1   MKVTYDKLKNTIKNALKASGVSEEKSELMAKVHAESTLKGVNSHGLNRIPRLIDFINKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+ + + S G++E ++     G + A K  DRA ELA +HGIG+V LRN  HWMRG
Sbjct: 61  VDINAEMELVKSFGSVENYEGNLGFGVINALKASDRAAELAKEHGIGMVTLRNTTHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMFS 179
           G+Y    A+KG IG+CWTN+ ++MP WG+ E  +G NP+ ++IPS      +DM++S++S
Sbjct: 121 GAYSENIADKGMIGMCWTNTESLMPVWGSDEISLGNNPIGISIPSESGNICLDMAISLYS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE  RL G +LP  GGFD  GNLT +P +IE+++ +LP+GYWKGSG+ I LD +A L
Sbjct: 181 YGKLETTRLKGEKLPYPGGFDKGGNLTDDPKLIEESQNLLPVGYWKGSGLGICLDTMAAL 240

Query: 240 LSDGASVAEVTQDNS-DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           LS+G S  ++   +  +    SQIFIA+  +        +  +++I + V SA   +   
Sbjct: 241 LSNGLSTYDMDDRDGFNCTSCSQIFIAMNPEAFSTKEENEKTIRKIKERVKSAHPTNPGL 300

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + R PG    T   +  R GI +DD ++ K+++L
Sbjct: 301 SPRYPGLGLYTRKEKGLREGIEIDDKIFKKVESL 334


>UniRef50_C9Z6D5 Putative malate dehydrogenase n=2 Tax=Streptomyces
           RepID=C9Z6D5_STRSW
          Length = 356

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 82/334 (24%), Positives = 144/334 (43%), Gaps = 5/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L         + GV +  A   A+        G  SHG+ R P ++ +L +G   
Sbjct: 5   VGSADLLNFAAATAEAHGVPAVDARLLADTLVTAELWGHPSHGMLRLPWYLDRLASGATT 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A P  +T  GA+   D    +G +   + +   +E A  HGI  VA+RN+ H+     
Sbjct: 65  AVAAPVTVTDSGAVLVVDGCDGLGQVLTSRAVTWGVERARRHGISAVAVRNSGHFGTAAY 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSY 180
           +  +AAE+G + +  TN+   M PWG +E  +GTNP  +A P       ++D++ +  + 
Sbjct: 125 FTRKAAEQGCVALLATNASPAMAPWGGREKSVGTNPWSIAAPGGRHGTVVMDIANTAVAR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   R  G  +P     D  G  T +P    +   ILPM   KG  +S + D++A +L
Sbjct: 185 GKIYHARERGEAIPDGWAADAGGVPTNDPRRAIE-GLILPMAGHKGYAISFMFDVLAGVL 243

Query: 241 SDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           +  A    V      +   G+  + I +++  + D    + +++ +++   +   A    
Sbjct: 244 TGSAFGTAVVGPYQPTGRSGVGHLLICVDIAAMADPAEFETRMEALIEETKAVPAAPGTA 303

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            I +PG          R  GIT+ D  W  +  +
Sbjct: 304 EIFVPGEPEARTAERLRSEGITLTDDTWTSLGRI 337


>UniRef50_A8TKN7 Malate/L-lactate dehydrogenase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TKN7_9PROT
          Length = 361

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 84/334 (25%), Positives = 150/334 (44%), Gaps = 5/334 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L+    RV  + G+    A   A+        G++SHGV R P ++++L    +
Sbjct: 12  RFPESVLRDTVARVFAACGMTDGDAVTLADSLVHADRRGIHSHGVLRVPDYVKKLTEDGV 71

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P   P+ ++  GA    D   ++G +     +D  I+ A    +   A+R +NH     
Sbjct: 72  DPRGHPRIVSDAGAALVIDGGNAMGQIAGTLAVDAVIDRARSVNVAFAAVRGSNHSGALD 131

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
            Y  + A +G IGI  +N++  M PWG  +  +G NP+ +A+P       ++D+++   +
Sbjct: 132 WYTMRIAAQGMIGIAGSNALPTMAPWGGVDKIVGLNPISIAVPGGEHGPIVLDVALGATA 191

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G + V     +Q+P    FD  G  T +         I P+G  KG G+++++ ++A++
Sbjct: 192 HGKIRVYAQKDQQIPEGWAFDASGVPTTDAAAALD-GLIQPIGGHKGIGLALMVGLLASV 250

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS      E     D +      Q ++AI V    D     A + R+      + RAD  
Sbjct: 251 LSGAGYGTESGNMVDGATPGADGQFYLAINVAAFRDIADFTAHISRVARQYRDSRRADGV 310

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           + + LPG     +   NRR+GI ++D   A I  
Sbjct: 311 ERLYLPGDLEAEVAERNRRDGIPLNDEAVALIVE 344


>UniRef50_Q28JS2 Malate dehydrogenase (NAD) n=1 Tax=Jannaschia sp. CCS1
           RepID=Q28JS2_JANSC
          Length = 362

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 92/335 (27%), Positives = 153/335 (45%), Gaps = 6/335 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHG--VNRFPRFIQQLENG 59
            V  EQL+        + G+  E A   A     +        G  V R  R+ +++ NG
Sbjct: 9   NVDREQLRTFVAEGFRALGLTEEDAGIFANALIFSELRFHPGQGQGVARLRRYHERIGNG 68

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
           ++ P A    +    A+   DA   IG + A K M  AI+ A + GIG V +RN+ H+  
Sbjct: 69  EVNPRAGWSIVKEGPALALVDAHNGIGTVAASKAMALAIKKAKEGGIGTVVVRNSTHYGS 128

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
              +  QA E G IG+ +TN+   M PWG +E   GTNP  +A PS     T++D++++ 
Sbjct: 129 SAVHACQALEHGCIGVAFTNAGPEMAPWGGREGVTGTNPWSIAAPSDQGFPTVLDIAITT 188

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
              GM+      G+++P+D     +G+ T +P    K   +L +G  KG G++ + + + 
Sbjct: 189 AGKGMMNWLIREGKKMPLDWAITPDGDETDDPAAALKGP-LLGIGGHKGYGLAFMTEALT 247

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            +LS G        D   +  +S  F AI+++  +D      ++   +    +       
Sbjct: 248 GVLSGGGFGLTPYSDP-QKLDVSHYFQAIDIEWFMDPDDYATRMGAFVQMAKTRALRPGF 306

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I +PG +     A    NG+ +DD V A +QAL
Sbjct: 307 DEILVPGEQEARRTAAKAENGVPIDDVVLADMQAL 341


>UniRef50_C0GVF2 Malate/L-lactate dehydrogenase n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GVF2_9DELT
          Length = 365

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 85/335 (25%), Positives = 149/335 (44%), Gaps = 10/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KVT   ++    ++LI  GV  E  +   +      +SG  +HG+ R P ++++++ G +
Sbjct: 24  KVTISAVRNISKQILIHVGVSPEHTEIIVDSIVYAHQSGKGTHGLGRLPLYVKKIQAGFM 83

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             +     +     +   DA+   G + A K MD  I  A  +GIGLV +R +N++    
Sbjct: 84  AAETSTDLVKDTPVLAVMDAKNGFGQVAATKAMDLCINKANYYGIGLVGVRRSNNFGTAS 143

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
               QAA KG IGI   NS   + P G      GTNPL +A P         +DM+ S+ 
Sbjct: 144 FITEQAAAKGMIGIVLGNSGPAIAPTGGSHPLFGTNPLGIAFPNPVGEFPISLDMATSVV 203

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +     +  ++P     D  G  T +P    +   ++P+G  KG G+S+ +D++A 
Sbjct: 204 ARGKVRQAAKSNEKIPFGWALDGNGQPTCDPFQALE-GSMIPIGDHKGYGLSLAIDILAG 262

Query: 239 LLSDGASVAEVT--QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           LL+  A   +V    D S       + + I VD  +       K+  ++  + S     +
Sbjct: 263 LLTGSAFGGDVHPLGDMSANSNYGHLCMTINVDFFMTIDEWSQKIAYLVSSIKSCG---D 319

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + IR+ G      +  N +  + V + V   I++
Sbjct: 320 PEKIRIHGESSHRSI-RNSKEYVLVKNRVINDIES 353


>UniRef50_B5RIN9 FI03684p (Fragment) n=8 Tax=Neoptera RepID=B5RIN9_DROME
          Length = 503

 Score =  323 bits (828), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 75/328 (22%), Positives = 141/328 (42%), Gaps = 14/328 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +        +  V    A+A A++       G +SHG+NR   +I  L      
Sbjct: 151 VAVAESRRFMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTD 210

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK +    A    D    +G +     MD AI+ A   G+G V  + +NH+   G 
Sbjct: 211 GAAVPKILKETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGW 270

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y  +A ++G +G+  TN+  +M P  AKE  +GTNPL +   +      ++DM+ +  + 
Sbjct: 271 YAIRAMDQGLVGMSMTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAV 330

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLD 234
           G +E+ R  G  LP     D  G +T +  +      ++P+G       +KG G+  ++D
Sbjct: 331 GKIEIQRRKGAPLPDGWAQDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVD 390

Query: 235 MIATLLSDGASVAEVTQD----NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +++ ++S      +V +           + Q+FIA++ +        + ++      +  
Sbjct: 391 ILSGVMSGANYSTQVRKWTHAGADSAADLGQVFIAVDPNCFAP--NFEERMADFNSRLRG 448

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNG 318
           A   D ++ + L G +    +A+    G
Sbjct: 449 ATPTDPSKPVLLAGDKEKKGMADVDAAG 476


>UniRef50_D2Q379 Malate/L-lactate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836
           RepID=D2Q379_9ACTO
          Length = 362

 Score =  323 bits (828), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 86/334 (25%), Positives = 157/334 (47%), Gaps = 6/334 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V    L+A  + V  + G +   A   A         GV SHG+   P ++++L  G 
Sbjct: 12  VLVRPAWLEATVSSVFTALGFEPVDAGQIAHSLVEADLRGVSSHGIMLVPMYVERLNAGG 71

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  + +   +   GA    DA+  +G L++ + M  AIE A  +GIGLV++RNA+H+   
Sbjct: 72  VTRERELDVLHDAGAAIVADARGGMGQLSSPQAMGLAIERAGRYGIGLVSVRNAHHFGAA 131

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
             +  QAA+ G +GI  +N+  +MP  G  E  +G NPL +A+P  +    ++DM++S  
Sbjct: 132 SRWAVQAADAGCLGIAMSNTTPLMPAPGGAERVVGNNPLAIAVPTEAGAELVLDMALSAV 191

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +   AGR +P +   D  G  T +         +LP    KG G+++++D++  
Sbjct: 192 ALGKIRLAAAAGRPIPDNWATDPSGLPTTDAEAAVL-GMLLPAAGHKGFGLALMIDVLTG 250

Query: 239 LLSDGASV---AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +LS G        + ++       + +F+AI+ + L        +   + + V ++  A 
Sbjct: 251 VLSGGGWGDRVRPLYREPDRPNDCAHLFLAIDPELLGGIEGFRQRSSALAERVRNSATAP 310

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
               + LPG        + RR G+ V+ S    +
Sbjct: 311 GVDRLYLPGEIEADRARQQRRTGVLVERSGLDGL 344


>UniRef50_A8RPZ9 Putative uncharacterized protein n=2 Tax=Bacteria
           RepID=A8RPZ9_9CLOT
          Length = 339

 Score =  323 bits (828), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 142/336 (42%), Positives = 205/336 (61%), Gaps = 4/336 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++TF+++K+   RVL+  G+  E A+ CA +   TT  GVYSHG NR  RF+  ++ G 
Sbjct: 4   MRLTFDEIKSEIKRVLVKYGMSEEKAETCARIHTETTYDGVYSHGTNRVARFVNYIQKGW 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P      GA+  ++     G L A    DRA+ELA  +GIG+V +RN  HWMRG
Sbjct: 64  VDVNAEPSLEREFGALRVYNGNMGPGVLNALYCADRAMELADQYGIGMVGIRNTTHWMRG 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
           G+YG  AA KGY  I WTN+ + MPPWG +ECR+G NP ++A+P         +DM+MS 
Sbjct: 124 GTYGLYAARKGYAAIMWTNTESCMPPWGGRECRLGNNPFVMAVPSADGGEPLQLDMAMSQ 183

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
           +SYG L+V RLAG +LP  GGFDDEGNLT +PG IE++RR+LP+GYWKGS  S +LD++ 
Sbjct: 184 YSYGKLQVTRLAGEKLPYPGGFDDEGNLTDDPGAIEQSRRVLPVGYWKGSAFSFMLDILG 243

Query: 238 TLLSDG-ASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++L+DG  +     +      G SQ+ I ++  +          +   + YV S+  ++E
Sbjct: 244 SVLTDGIGAAGMDQKGYGSCGGCSQVMIVVDPGRTTTDAHMKEIVDTAVLYVKSSAPSEE 303

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             ++R PG        E+ R GI VDD VW +IQ+L
Sbjct: 304 GGSVRAPGQGSARFHEEHDRLGIYVDDDVWKEIQSL 339


>UniRef50_C8WTM6 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alicyclobacillus
           acidocaldarius RepID=C8WTM6_ALIAD
          Length = 353

 Score =  322 bits (827), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 89/335 (26%), Positives = 148/335 (44%), Gaps = 6/335 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L+A       + GV    AD  A     +   G+ SHGV R P ++  L++G + 
Sbjct: 5   VAPASLQAFARACFAAAGVAKRDADWSATALVESDLRGISSHGVMRLPWYLHGLKSGKVN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+ +     +       DA  ++G ++AK+    A+ELA + G+G VA+R ANH      
Sbjct: 65  PNPRLVWRRTGPVTAVLDADDALGFVSAKEAAAHAVELAREAGLGAVAVRRANHCGALFL 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y   A   G +G C  N+   + P G ++  IGTNP+  A P+       +D+S S  S 
Sbjct: 125 YAEWATLYGMVGFCCANTHPALAPPGGRKPVIGTNPIAFAAPTPLDYPLSIDLSTSAISR 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +      G  LP     D++G  TKEP        +LP+G  KG  ++++++++A +L
Sbjct: 185 GAVIERARRGESLPDGVAVDEDGAPTKEPHRALS-GALLPIGGAKGYALALMVEVLAGVL 243

Query: 241 SDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      +V     D+    G    ++A+  D  +       ++  ++  +  A  A   
Sbjct: 244 AGAQVAGDVGFMFADDGKPPGNGFFYLALHPDFFVGQEAFLQRMASLVAEIHDAPSAQGQ 303

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I +PG           R GI + D VWA +  L
Sbjct: 304 PPISVPGERRHRERVSRSRRGIPISDEVWADLAEL 338


>UniRef50_A8TYW6 Hypothetical oxidoreductase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TYW6_9PROT
          Length = 352

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 90/339 (26%), Positives = 157/339 (46%), Gaps = 9/339 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +  E+L     R++   G D   A+  A    +    G  SHGV   PR+++    G 
Sbjct: 1   MIIGHERLTGIVTRMIQGAGSDLAEAETVATNLVQANLMGHDSHGVGLAPRYMKHARAGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    +P  IT  G     D     G    ++  + AI  A + G  +V LR  +H  R 
Sbjct: 61  MNLGVRPSVITDNGVYLLLDGNMGYGQTVCREATEMAIARAKEKGAAIVGLRRTHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMS 174
           G++G   AE G I I + N+      + P+G  E R  TNP   AIP+   TP+ ++DM+
Sbjct: 121 GAWGEMCAEAGLISIHYVNTTGHRPYVAPYGGFEARYSTNPYCTAIPATDKTPMIVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIV 232
            S  + G + V   AG++ P D     +G  T +P VI +     +L  G  KG G++++
Sbjct: 181 TSRVAQGKVRVAYYAGKKTPADALVGPDGLPTDDPKVIFEEPYGAMLSFGQHKGYGLAMI 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A  L+ G +  E   D +     + + I I+           +++ +++++V+S++
Sbjct: 241 CEILAAGLTGGGTAREELMDQNTICN-NMLMIVIDPKGFGADIPFRSEIDQLVEHVSSSK 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A     +R PG      +AE    GI +DD+ W +++ 
Sbjct: 300 TAVGFDKVRFPGDPEREAMAERAAKGIWIDDNTWGEMRQ 338


>UniRef50_P30178 Uncharacterized oxidoreductase ybiC n=90 Tax=Proteobacteria
           RepID=YBIC_ECOLI
          Length = 361

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 143/335 (42%), Gaps = 9/335 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   + L +    V    G + + A   A+       +G  SHG+   P +++    G +
Sbjct: 6   RFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHL 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             +   K +   GA    D  R+ G + A + M   IE A  HGI  VAL N++H  R G
Sbjct: 66  QINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIG 125

Query: 122 SYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
            +  Q A  G++ I + +   I ++ P+  ++ R GTNP  V  P       ++D + S 
Sbjct: 126 YWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSA 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIVLDM 235
            ++G   V    G  +P     D  G  T  P V++++    +L     KG  ++ + ++
Sbjct: 186 IAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEI 245

Query: 236 IATLLSDGASVAEVT-QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           +   LS G +  + T Q + D        I I  +        +A+ +   ++V ++   
Sbjct: 246 LGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPD-CNAQTEAFAEWVKAS-PH 303

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           D+++ I LPG        E ++ GI +D   W  I
Sbjct: 304 DDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAI 338


>UniRef50_D2SBU9 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SBU9_9ACTO
          Length = 353

 Score =  322 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 83/336 (24%), Positives = 156/336 (46%), Gaps = 6/336 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  + L+A    VL + GV  + A   A+   +    G  SHG+ R P +  +L +G +
Sbjct: 5   RIEPKLLRAFGTGVLTALGVPGDDAALVADSLVQADLWGHQSHGLLRLPWYGARLRSGAM 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++  G +   D +  IG +  ++    A+E A  HG+G+V +RN+NH+    
Sbjct: 65  RAVPEPAVLSDTGPLVLLDGRDGIGQVLTERARRLAVERARTHGVGVVGVRNSNHFGTAM 124

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM--VDMSMSMFS 179
            +  +AA  G + +  TN+   M PWG +E R+GTNP  +A P    T+  +D++ +  +
Sbjct: 125 WFTRRAAHDGVVAVLTTNASPAMAPWGGREKRVGTNPWSIAAPGPDGTVLALDIANTAVA 184

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + + +  G  +P       +G  T +P        +LPM   KG  ++ ++D+++  
Sbjct: 185 RGKIHLAKNRGEPIPDTWALTADGAPTTDPEEGVL-GVLLPMAGHKGYAIAFMMDVLSGA 243

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A    V    +     G   +F+A++ D   D    +A++++++D V S   A   
Sbjct: 244 LTGSAVGTGVHGPYEPDARSGCGHLFLALDPDAFGDRAGYEARVRQLVDEVASVPLAQGF 303

Query: 298 QAIRLPGHEFTTLLAENR-RNGITVDDSVWAKIQAL 332
             +  PG       A N    G+ +     A ++ L
Sbjct: 304 DGVLHPGQVEDRAEAANLAAGGVVLARDSLAGLRRL 339


>UniRef50_UPI0000588C5F PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000588C5F
          Length = 411

 Score =  322 bits (825), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 76/340 (22%), Positives = 154/340 (45%), Gaps = 13/340 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V   +  +   R +++RG +   A   AE+       G +SHG+NR   +++ +E+G 
Sbjct: 22  VLVKVAEAHSFIERCMVARGTNPTHASLLAELLVSADSRGHFSHGLNRIDVYLENVEHGV 81

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
              D +P  I  +      D +  +G +  +   D  IE A   GIG V  + +NH+   
Sbjct: 82  TAGDGEPVIIKEMAGTAWVDGRNLLGPVVGQFCTDLVIEKAKQAGIGWVVAKGSNHYGIA 141

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
           G Y  +  + G IG+ +TN+   + P  +K+   GTNP+  + P+       +DM+ +  
Sbjct: 142 GWYSMRIKDTGMIGLSFTNTSPCVYPTRSKQIITGTNPIACSAPANNGDSFDLDMATTTV 201

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL------PMGYWKGSGMSIV 232
           +YG +E+  L G+ LP   G + +G  T +P  +     +         G +KG+G++++
Sbjct: 202 AYGKVEICHLKGQTLPSGWGSNSDGKETSDPKEVLNGGGLQPLGGGETTGGYKGTGLALM 261

Query: 233 LDMIATLLSDGASVAEVTQDNSD--EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +++I  +L        + + ++   E  + Q F+A+  +    G     ++  ++    +
Sbjct: 262 VEVITGILGGAHFGTNIRKWSAGEREADLGQCFVALNPEAFAPG--FSERMTSLIAMCRN 319

Query: 291 AERADENQAIRLPGHEFTTLLAENRRN-GITVDDSVWAKI 329
           AE A+    + + G      + +  R  GI    ++  K+
Sbjct: 320 AEPANGETEVLVAGDRARHHMEKVAREGGIKYHRNLITKL 359


>UniRef50_C5TC94 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5TC94_ACIDE
          Length = 376

 Score =  320 bits (822), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 142/336 (42%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            + F +L+A   ++ +  G   E A   A   A     G  SHG+ R P ++  L +G +
Sbjct: 39  HIAFAELQALLTQIFLRHGTSPEVAAILAANCASAQRDGADSHGIFRIPGYLSTLASGWV 98

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+           DA         +      I+ A  +GI L+A+RN++H+    
Sbjct: 99  NGRAVPQVEDVAPGYVAVDAGNGFAQPALEAARGLLIDKARRNGIALLAIRNSHHFAALW 158

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 A +G + + + NS+A + P G  +   GTNP+  A P       + D++ S  +
Sbjct: 159 PDVEPFAREGLVALAFVNSMACVVPTGGHKALFGTNPIAFAAPRAGGDPLVFDLATSAIA 218

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G +++    G +LP   G D  G  T +P  I     +LP G +KGS +S++++++A  
Sbjct: 219 HGDVQIAAREGHRLPEGYGVDRLGQPTCDPAAILDGGALLPFGGYKGSALSMMVELLAAA 278

Query: 240 LSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+ G    E        +      ++ I I+  K   G     + + ++ ++        
Sbjct: 279 LTGGNFSFEFDWSQHPGAKTPWTGELLIVIDPSK-GAGNQFARRTETLVQHMR------G 331

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               R PG       A++ R+GI +     A++  L
Sbjct: 332 AGQNRQPGDRRYQQRAQSDRDGIAITGEELARLHEL 367


>UniRef50_A4GHI0 Malate dehydrogenase n=1 Tax=uncultured marine bacterium EB0_35D03
           RepID=A4GHI0_9BACT
          Length = 335

 Score =  320 bits (821), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 73/338 (21%), Positives = 144/338 (42%), Gaps = 14/338 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++++ ++        L +     E A   A+        G   HG++R P +++Q+  G 
Sbjct: 5   LQISEKEAWDLAFNALTNNQTSDENAKEVADALINAEFDGQAGHGLSRIPSYVEQVIAGK 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +     P  ++S G++ + DA            +    +     GI   ++  ++H+ + 
Sbjct: 65  VAGKVSPSILSSKGSVIRVDANHGFAFPAISLALSEITKTCKSFGIAAASISRSHHFGQA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G +  + AE G IG+ + N+   +PPWG  +   GTNP+  A P       ++DMS+S  
Sbjct: 125 GRHVERLAEVGLIGLMFGNTPKAIPPWGGTQALFGTNPIAFASPRDSSVPLVIDMSLSKV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + V      ++P D   D +G  T +     +   +LP+G  KGS ++++++++A 
Sbjct: 185 ARGKVMVANQLNEKIPEDWAIDKDGKPTTDAKKALE-GAMLPIGDAKGSALALMVEVLAA 243

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+      E         D  G+ Q+ IAI+      G +   + + ++  V       
Sbjct: 244 GLTGSNFGFEASSFLNAEGDAPGVGQLIIAIDPSFF-SGESFGERTETLVGAVLEQP--- 299

Query: 296 ENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
                RLPG +         +   IT+   ++ KI+ L
Sbjct: 300 ---GTRLPGDKRIEKRKVREKSETITISKDLYEKIERL 334


>UniRef50_Q1YIU0 Putative malate dehydrogenase n=1 Tax=Aurantimonas manganoxydans
           SI85-9A1 RepID=Q1YIU0_MOBAS
          Length = 381

 Score =  319 bits (818), Expect = 9e-86,   Method: Composition-based stats.
 Identities = 75/335 (22%), Positives = 154/335 (45%), Gaps = 5/335 (1%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +V     +     +L + G+    A   A++       G+ SHG+   P + QQL NG  
Sbjct: 31  RVASATWRRQALAILSAWGMSDAHAAVTADVLVAADLMGIDSHGLTLLPLYDQQLGNGGA 90

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                 + +  +GA+   D     G +     +D A E A   GI  +++RN+NH+   G
Sbjct: 91  TATPNIEVVHDMGAVALIDGDAGFGQVPGMMAVDMAAERAGRFGISAISIRNSNHYGAAG 150

Query: 122 SYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
            Y  + AE+G +GI  ++   A + P G    ++GTNP+  A PS      ++DM+ S  
Sbjct: 151 VYVRRLAEQGLVGISTSSVWRAGIVPTGGLAPKLGTNPIAFAAPSARGQPFLLDMATSTA 210

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G L++ + A  +LP       +G   ++P +   +  + P+G  KG G++ +++++++
Sbjct: 211 AIGKLKLAQRAETELPEGWALTRQGTPQRDPNLALLDPLLAPLGGHKGYGLATMVEVLSS 270

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSAERADEN 297
           +LS  A    +      ++ +    +A++   +       +A L R++D + + +  D  
Sbjct: 271 VLSGAAL-TPLRGKPGQKHDVGHFILALDPAMIRGSRAAFEADLDRMVDGLRATDPIDPA 329

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + + G       A+   +GI +   + A+++ +
Sbjct: 330 HPVMVAGDPEYAREADRLAHGIPLSSKLAAQLREI 364


>UniRef50_Q9XTB4 Protein VF13D12L.3, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9XTB4_CAEEL
          Length = 400

 Score =  319 bits (818), Expect = 9e-86,   Method: Composition-based stats.
 Identities = 77/341 (22%), Positives = 142/341 (41%), Gaps = 13/341 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  +++K      +   G     A   A +       G YSHG+NR   +++ +E     
Sbjct: 49  VAKDEMKRFMVECMTKVGATESHATQLALVLLEGDIRGHYSHGLNRLDMYVRDIEQNVCK 108

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            D +P  +         D    +G +     MD AIE A + GIG V  + +NH+   G 
Sbjct: 109 GDGEPIILKEKAGTAWVDGNNLLGPVVGNFCMDLAIEKAKNAGIGWVVAKGSNHYGIAGW 168

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           Y  +A +KG +G+  TN+  +  P  +    +GTNP+ +A P       ++DM+ +  + 
Sbjct: 169 YALRAMKKGMLGMSMTNTSPISFPTRSAVPALGTNPISLAAPGTGDDSFVLDMASTTVAI 228

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM------GYWKGSGMSIVLD 234
           G +E+       +P+  G  + G  T +P  +     +LP+      G +KG G+S +++
Sbjct: 229 GKVELAARKENPVPLSWGVGEGGKETTDPTKVLYGGGLLPLGGVEVSGGYKGYGLSSMIE 288

Query: 235 MIATLLSDGASVAEVTQDNS--DEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +   +L+       V +  S   E  + Q F+AI+ +    G     +LQ  M  + +  
Sbjct: 289 IFCGILAGAHWGPHVRKWMSTKSEADLGQCFVAIDPEAFAPG--FADRLQDFMQTMRALP 346

Query: 293 RADENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
            +  +  + + G       A   +  GI    +    +  L
Sbjct: 347 TSSPSFKVEVAGDMERRHEALVEQLGGIPYHKNQITFVNDL 387


>UniRef50_A1WAI4 Delta1-piperideine 2-carboxylate reductase n=22 Tax=Proteobacteria
           RepID=A1WAI4_ACISJ
          Length = 350

 Score =  318 bits (816), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 82/340 (24%), Positives = 144/340 (42%), Gaps = 16/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            V F+ L+    R+    G  +E A   A   A     G +SHGV R P ++  L +G +
Sbjct: 13  HVPFDDLRGTLARIFERHGTSAEVAAVLAHNCASAERDGAHSHGVFRIPGYLSTLASGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+           DA         +      +  A  +G+ L+A+RN++H+    
Sbjct: 73  DGRAVPRVEDVAPGYLAVDAGNGFAQPAYRAAYSALVAKARANGVALLAIRNSHHFAALW 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 A+ G + +   NS+A + P G      GTNP+  A P       + D++ S  +
Sbjct: 133 PDVEPLADDGLVALALVNSMACVVPSGGTTALFGTNPIAFAAPRAGHEPLVFDLATSAIA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY----WKGSGMSIVLDM 235
           +G +++    GR LP   G D  G  T +P  I     +LP G     +KGS +S+++++
Sbjct: 193 HGDVQIAAREGRLLPDGHGVDRHGQPTNDPRAILDGGALLPFGGVHSSYKGSALSMMVEL 252

Query: 236 IATLLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           +A  L+ G    E        +      ++ IAI+  K   G +   + + ++  + +A 
Sbjct: 253 LAAALTGGNFSFEFDWSGHPGAQTPWTGELIIAIDPAK-SAGRSFAQRCEDLVQAMAAA- 310

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                   R PG       A + ++GI +  + WA++Q L
Sbjct: 311 -----GQTRQPGERRYRQRARSLKDGIPLPATTWAELQRL 345


>UniRef50_Q125D0 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=Q125D0_POLSJ
          Length = 364

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 85/339 (25%), Positives = 150/339 (44%), Gaps = 10/339 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++  QL+A    VL + G  +E A   A        SG  SHGV   PR++  +  G + 
Sbjct: 15  ISAAQLRAQVATVLKAAGSSAEEATTVAANLVLANLSGHDSHGVGMLPRYVDAVLEGGLK 74

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P++  + +   G++   D QR  G +  ++ M   I+ A  HG  ++ L NA+H  R G 
Sbjct: 75  PNSSVRVVLDTGSLLTLDGQRGYGQIVGEQAMALGIDRAKAHGSCIMTLGNAHHLGRIGH 134

Query: 123 YGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           +   A ++G + + + N  S  V+ P+G  + R GTNP  + +P       ++D + S  
Sbjct: 135 FAEMAVDQGLVSLHFVNVLSRPVVAPFGGGDGRFGTNPCCIGVPLKGREPFVLDFATSRV 194

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN------RRILPMGYWKGSGMSIV 232
           + G + V    G Q+      D+ G  T +PGV+           +L  G  KG GM++ 
Sbjct: 195 AQGKMRVAHNKGIQVEPGTLIDEHGRPTTDPGVVVVPQSNGLFGALLAFGEHKGYGMAVA 254

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++   L+ G +  + T           + I I+  KL      + +    +D++ +  
Sbjct: 255 CELLGGALTGGGTWHKATDPAVRAVVNGMLTILIDPAKLGTQAAFEQEAVAFVDWLQAGP 314

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A    A+++ G       A+    GI VDD  W ++ A
Sbjct: 315 VAPGFDAVQIAGDPERATRAQREVEGIAVDDQTWQEMVA 353


>UniRef50_C6VL76 Malate dehydrogenase (Putative) n=3 Tax=Lactobacillus plantarum
           RepID=C6VL76_LACPJ
          Length = 362

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 90/349 (25%), Positives = 148/349 (42%), Gaps = 21/349 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   ++++     +    G   E +   A M   T   G+ SHGV R   +   + NG I
Sbjct: 4   RYNSKKIEQLIYNIYKGYGFTEEESQEVAHMLIYTDLIGIESHGVQRMIMYDDFIRNGKI 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P+ +         DA   +G L     M  AIE A  HGIG+V  RN+ H+   G
Sbjct: 64  RVHNRPEVVKETDVSAVVDAHFGLGQLNGIYSMRLAIEKAKQHGIGIVTTRNSGHYGIAG 123

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSY 180
            Y   AAE+G IG+   NS + M P  A +  +GTNP+  A+P+ P   + D + +    
Sbjct: 124 YYANMAAEEGLIGLSSCNSRSAMLPTHATKALVGTNPIAFAMPANPNTFIFDAATTTVPQ 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEG-------NLTKEPGVIEK---NRRILPMGY------- 223
           G +EV R  G+ +P       +G       N TK+   +     N  + P+G        
Sbjct: 184 GKIEVYRKLGKDMPALW-VAKDGETPVNSHNDTKDLDALRDLDSNVGLAPLGGVTEDTGS 242

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KG G+ +++++   +LS G +  E+T D     G  Q F+AI+     D     AK   
Sbjct: 243 HKGFGLGVIVEVFTAILSMGNTSNEITPD-DLSVGPCQSFVAIDPSIFGDKDAIIAKFSA 301

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  +         + + + G +      +   NGI +DD   A++  +
Sbjct: 302 YLQAIRDLPSVPG-KPVIVAGDKEAAAYQDRSANGIEIDDKTLAEVTGI 349


>UniRef50_D0KCK6 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=D0KCK6_PECWW
          Length = 355

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 91/340 (26%), Positives = 147/340 (43%), Gaps = 10/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++  +L A    VL   G +   A    E        G  SHG    P +++ +  G 
Sbjct: 1   MQISANRLMATVQVVLQKAGCEENEARIVTEHLVAANLKGHDSHGAGMLPHYVEFIGKGI 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+   R  G  T K+ M  AIE     G+ L+ L +  H  R 
Sbjct: 61  MHPNTPARLLRDSGAVLQFTGDRGFGQRTGKEAMQAAIERVKTTGVCLMTLSSTCHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPSTPI---TMVDMS 174
           G+YG  AA+ G + I + N      ++ PW   E R GTNP+ +A P T      ++D +
Sbjct: 121 GTYGEMAADAGLVSIHFVNVNDLEPIVAPWCGSEARFGTNPICIAFPPTEHNAAFVLDFA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN---RRILPMGYWKGSGMSI 231
            S+ + G   V  LAG+    +   D  G  T +P V+ +      + P+   KG G+ +
Sbjct: 181 TSVVALGKTRVAYLAGKTFDEEVMLDCNGVSTNDPKVMWEGEKHGALKPIAKHKGGGLIL 240

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             +M+A LLS G ++             +   I I+   ++       +   ++DYV S+
Sbjct: 241 AAEMLAGLLSGGGTIQPENVRQGAIVN-NMTTIVIDPTSMVSMAWLQKEYDAMLDYVRSS 299

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              D  Q I + G       A+ R +GI V D  W KI  
Sbjct: 300 TAPDPTQPILIAGEPERLSQAQRRADGIYVSDQEWQKIVE 339


>UniRef50_Q8IPU0 CG10512, isoform B n=26 Tax=Eumetazoa RepID=Q8IPU0_DROME
          Length = 381

 Score =  317 bits (813), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 75/328 (22%), Positives = 141/328 (42%), Gaps = 14/328 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +        +  V    A+A A++       G +SHG+NR   +I  L      
Sbjct: 29  VAVAESRRFMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTD 88

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK +    A    D    +G +     MD AI+ A   G+G V  + +NH+   G 
Sbjct: 89  GAAVPKILKETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGW 148

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSY 180
           Y  +A ++G +G+  TN+  +M P  AKE  +GTNPL +   +      ++DM+ +  + 
Sbjct: 149 YAIRAMDQGLVGMSMTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAV 208

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLD 234
           G +E+ R  G  LP     D  G +T +  +      ++P+G       +KG G+  ++D
Sbjct: 209 GKIEIQRRKGAPLPDGWAQDPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVD 268

Query: 235 MIATLLSDGASVAEVTQD----NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           +++ ++S      +V +           + Q+FIA++ +        + ++      +  
Sbjct: 269 ILSGVMSGANYSTQVRKWTHAGADSAADLGQVFIAVDPNCFAP--NFEERMADFNSRLRG 326

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNG 318
           A   D ++ + L G +    +A+    G
Sbjct: 327 ATPTDPSKPVLLAGDKEKKGMADVDAAG 354


>UniRef50_A2SP37 L-sulfolactate dehydrogenase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SP37_METPP
          Length = 365

 Score =  317 bits (813), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 87/340 (25%), Positives = 151/340 (44%), Gaps = 10/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V   +L+     +  + GV  E AD  AE+       GV SHGV   PR+++ +  G 
Sbjct: 9   VLVDSGELRMKVAGLFQAVGVSPEHADQIAEVVVFADLRGVESHGVQFTPRYVRGIARGH 68

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P    + +   GA+   DA   +G L+A++ M  A+ +AA+HG G VA+RN+NH+   
Sbjct: 69  LNPKPDIRVVHRRGAVAVVDADNGLGFLSARRAMKEAMAIAAEHGSGSVAVRNSNHFGPA 128

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             Y   A E G IG   T+       WG++   +  +P+  A P+      +VD + +  
Sbjct: 129 AFYPMMALEAGMIGYATTDGPPHTVVWGSRRPVLSNDPVGWAFPTLEGLPIVVDTAFTGV 188

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
               + +    G  +P D     +GN T +P V  +   +LP+G  KGS + I  +++  
Sbjct: 189 -KEKIRLAAQRGGTIPADWAVGPDGNPTTDPKVALE-GYLLPIGQHKGSALIIANEVVCG 246

Query: 239 LLSDGASVAEV------TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            L+      EV        D+ D +       A++     D      +   +   + +A 
Sbjct: 247 ALAGALFSFEVSPKLVMGADHHDSWKCGHFVQALDPGAFGDRDAFLRRTSELASALRNAP 306

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           RA+  Q I +PG     L A+  R+G+ +  +    + A+
Sbjct: 307 RAEGVQRIYMPGEIEAELSAQRLRDGLPLAVTTLEALDAV 346


>UniRef50_C6DD67 Malate/L-lactate dehydrogenase n=7 Tax=Enterobacteriaceae
           RepID=C6DD67_PECCP
          Length = 362

 Score =  316 bits (811), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 90/336 (26%), Positives = 158/336 (47%), Gaps = 10/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            T   L+      L    VD+  A   A+    ++  G  SHGV+  PR+I  +  G + 
Sbjct: 26  FTHHYLRDYLRDRLTENDVDASIAGTVADNLVESSLKGHDSHGVSMLPRYIDAIREGGLS 85

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P AQ ++    G +  +D Q+  G + AK+ +   I  A  HG+ +V+L NA+H  R G+
Sbjct: 86  PHAQAEKTLDFGPLISFDGQQGFGQVVAKQALTEGIARAQTHGLVVVSLANAHHLGRIGA 145

Query: 123 YGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           +  QAAE G + + + N  +  V+ PW  ++ R GTNP    IP       ++D + S+ 
Sbjct: 146 WAEQAAEAGLVSLHFANVYTKPVVLPWQGQQARFGTNPFCAGIPVEHDDPVILDFATSVI 205

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIVLDMI 236
           +     +    G+ +      D+EGN T +P  + +     +LP G  KGSG+S+V  ++
Sbjct: 206 AGNKARIAWNEGKSVAPGCIVDNEGNPTVDPRWLMEQPLGALLPFGEHKGSGLSLVCSLL 265

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
              L+ G +     +    +   S + I I+  KL    T   ++  ++++V  +    +
Sbjct: 266 GAALTGGKT-ERTAKGEGKQIINSMLSILIDPQKLGGAATYQQEIPALLEWVRQSR---D 321

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  + LPG +      + + NGI VDD  W ++  L
Sbjct: 322 DNELLLPGDKEKQTYRQRQENGIFVDDVSWGQLSYL 357


>UniRef50_A8LST0 Dehydrogenase n=3 Tax=Bacteria RepID=A8LST0_DINSH
          Length = 351

 Score =  316 bits (810), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 82/336 (24%), Positives = 147/336 (43%), Gaps = 7/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ E L+    R L +RGV ++ A+  A +       G  +HGV R  +++ +LE G   
Sbjct: 6   ISAEALQDFVARALSARGVPTQDANKVAGLMVEADIYGYGTHGVFRLRQYLARLEGGGCN 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P      +    A    D     G+L      D A+E A   GIG V +R  NH      
Sbjct: 66  PAPNISVLQQTVATALIDGDNGFGHLAMAAARDLAMEKARQAGIGWVGVRRGNHAGPLAL 125

Query: 123 YGWQAAEKGYIGICWTNSIA-VMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMFS 179
           Y    AE G +G+      A  +PP+G  +  +GTNP+  + P+      + DM+ ++ +
Sbjct: 126 YVRPQAEAGLLGMAAAVGSANHVPPYGGTDLLLGTNPIAFSAPAEGPDPFVFDMATTVAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G ++     G  +P       +G    +P   +    +LP+G  KG G+S+ + ++A +
Sbjct: 186 MGKIKTLLQQGADMPEGWMVGRDGKPLTDPAR-KSEGFLLPIGGPKGFGLSVAIGLMAGV 244

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+  A  ++V   T D +      Q  +A++      G       +R+   + ++     
Sbjct: 245 LNGAAFGSDVVDFTSDTTSPTNTGQFVMALDPAAFGLGDGFAETARRVFGEMRASPPLPG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  +RLPG   T      RR G+T++ ++   + AL
Sbjct: 305 HHPVRLPGDGKTQAAETRRRQGLTLNPALRKDLDAL 340


>UniRef50_C5EL83 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C5EL83_9FIRM
          Length = 349

 Score =  315 bits (809), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 128/334 (38%), Positives = 199/334 (59%), Gaps = 2/334 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ ++ +K    +  ++ G+  E A+ CA +  +++  GV SHG+NR PRF++ ++ G 
Sbjct: 3   LRIPYDTIKETVKKAFLNVGLSEEQAEVCATIHTQSSADGVESHGLNRIPRFVEYVQKGW 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  + +P+   + GA+E +D    IG   A    DRA+ELA +HGIG V L+N  HWMRG
Sbjct: 63  INLEGKPELAGARGAVENYDGHLGIGITNALFCADRAMELAKEHGIGCVTLKNTTHWMRG 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G+Y W+ AE G++GI W N+ + MP WG+ E  +G NP  +AIP      ++DM+MS ++
Sbjct: 123 GTYAWRMAEAGFMGISWINTESCMPLWGSDEPGVGNNPFCIAIPREDGPIVLDMAMSQYA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG L V RLAG++LP  GGFD +GNLT +PG IE+++RILP GYWKGSGM+I LD+ A L
Sbjct: 183 YGKLGVYRLAGKELPFPGGFDKDGNLTSDPGAIEESKRILPTGYWKGSGMAIALDLAAAL 242

Query: 240 LSDGASVAEV-TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++G    ++   +     G  Q+FIA +           + L R +    ++    E  
Sbjct: 243 LANGNCGTDMDEANQGSCTGCCQVFIAFDPYLFGSKDEIQSMLNRRVAAADASHPEREGS 302

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  PG    +  A +   G+ VD+ VW ++QA+
Sbjct: 303 HVTCPGERTVSTRARSMAEGVNVDELVWEQVQAI 336


>UniRef50_C1TNX4 Malate/lactate dehydrogenase n=1 Tax=Dethiosulfovibrio
           peptidovorans DSM 11002 RepID=C1TNX4_9BACT
          Length = 362

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 84/348 (24%), Positives = 151/348 (43%), Gaps = 17/348 (4%)

Query: 1   MKVTFEQLKAAFNRVLIS-RGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG 59
           M V+++ L      +L    G     A   AE+        V SHGV R   + + LE G
Sbjct: 1   MIVSYDGLTRHVMDILEKGLGYTESQARITAEVLVEADARAVPSHGVARLAFYRKNLEGG 60

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
               D +P+ +         D +  IG   A   MDR ++ A + G     +R++NH+  
Sbjct: 61  FAFTDREPQVVRETPVSLVVDGKSGIGPSVAAFSMDRCVDKALEIGTCSCVVRDSNHYGM 120

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSM 177
            G +  +AA++G + +  TN+         KE  +GTNP+ VAIP     + ++DM+  +
Sbjct: 121 AGLWAERAAKRGCMAVAMTNTRKCCIVTFGKERLLGTNPIAVAIPGSGEEMFLLDMATPV 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK-NRRILPMGY------------- 223
            ++G +EV     + +P+    D+ G++T +   IE   +    +G              
Sbjct: 181 VAHGKVEVYDRRKKPMPLGWVVDETGSVTDDASHIEDLFKSESSLGGHLFLGGEGEELGG 240

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KG G+ ++++++ + LS G    E  Q+     GI+  F A  +D   D       +  
Sbjct: 241 HKGYGLGLMVELLCSALSLGRWSPETFQEPGSGSGITHYFAATRLDVFGDESAIKDSVSS 300

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           I++ V  +E+AD +  I + G +         R GI +D +    ++ 
Sbjct: 301 ILESVRRSEKADGHDRIFIHGEKEREARERAVREGIELDRATEDMLRR 348


>UniRef50_D2R8T1 Malate/L-lactate dehydrogenase n=3 Tax=Planctomycetaceae
           RepID=D2R8T1_9PLAN
          Length = 351

 Score =  315 bits (807), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 83/336 (24%), Positives = 149/336 (44%), Gaps = 12/336 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  + L      +L++ G   E A   +         G  SHGV R P ++  +++G+++
Sbjct: 4   IAADSLTKFAEAMLLAGGATPEEARITSVSLVDANLRGYESHGVMRIPYYLDAIQSGEVV 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+ K +    A    D Q   G + A ++ +    LA   G+ +  +  + H  R G 
Sbjct: 64  PAAELKILDQGAARVVADGQWGFGQVQAVRLFELLAPLAQQEGLAVGTMIQSGHIGRLGE 123

Query: 123 YGWQAAEKGYIGICWTNSIAV---MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           Y   AA +G + I   NS      + P G K  R+ TNPL + +P      ++D S S  
Sbjct: 124 YNEMAAARGLVSILMVNSHGAAVRVAPPGGKAPRLSTNPLAIGVPCGDAPLVLDFSTSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGY---WKGSGMSIVL 233
           + G + V ++AG+ +P     D+EGN T +P  +       ILPMG    +KG G+ +++
Sbjct: 184 AEGKVRVKKIAGQAVPEGWLLDNEGNPTTDPNTLYGNPPGSILPMGGTQSYKGFGLGLMI 243

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           +++   LS G +   V      + G     + ++  +        A++ +++DY+ +  R
Sbjct: 244 EILTGALSGGVTARPV---PYPKKGNCVFMMLVDPARFGGSDHFAAEVTQLVDYIRTTPR 300

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +    I LPG     L A  +  G+  D   W  +
Sbjct: 301 VEGCNEITLPGDPERKLYAARKSTGLVFDPENWKAL 336


>UniRef50_Q11JG3 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11JG3_MESSB
          Length = 375

 Score =  314 bits (805), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 72/343 (20%), Positives = 149/343 (43%), Gaps = 11/343 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M   + Q +     +L++ G+    A   A++       GV SHG++    +  +   G 
Sbjct: 1   MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A  K +         D    +G++      D AIE A   GI + ++RN++H+   
Sbjct: 61  LKMNADFKVVRETPVSVLIDGDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAV 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
           G +   AA  G I +  T++  + + P    E ++GT+PL  A PST     ++DM+ + 
Sbjct: 121 GYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLSFAAPSTDENPFLLDMATTT 180

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMGY------WKGSGMS 230
            +YG +         +P+  G D  G  T +P  V  +   + P+G       +KG G+S
Sbjct: 181 VAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS 240

Query: 231 IVLDMIATLLSDGASVAE-VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVT 289
           ++++++++ LS    + + +       + I   ++A++     D    +  +      + 
Sbjct: 241 VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALR 300

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +  +E   + + G     +  E  R G+ +   + AK+ A+
Sbjct: 301 NTKPVEEGTPVMVAGDPQWKMAEERLREGVPIGKGLRAKLIAV 343


>UniRef50_B7UIS0 Predicted malate/L-lactate dehydrogenase-family protein n=34
           Tax=Enterobacteriaceae RepID=B7UIS0_ECO27
          Length = 336

 Score =  314 bits (804), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 72/336 (21%), Positives = 143/336 (42%), Gaps = 9/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ E LK+  +  L + G+D++T     ++      +GV+SHGV     +  +L  G 
Sbjct: 4   VYVSEENLKSLVHHKLHTAGLDTDTTQQVTDVLVHADITGVHSHGVMCVEHYCTRLAAGG 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +    Q        ++   D+   +G+       + AI+LA   G+G V+++N +H    
Sbjct: 64  LNKAPQFSIEQISPSVAILDSDDGMGHSALITATEHAIKLAQQEGLGFVSVKNTSHCGAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
             +      KG + I  T +   + P G  E  +GTNP+    P       +VDM+ S  
Sbjct: 124 SYFAEMITNKGLVAIVMTQTDTCVAPHGGAERFLGTNPIAFGFPVENSHPMIVDMATSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++G +   +  G+ +      D  G  T +P  IE    +LP G  KGSG+++ +D +  
Sbjct: 184 AFGKILHAKETGKHIGEGLAIDKNGYGTTDPYKIEN---LLPFGQHKGSGIALAIDALTG 240

Query: 239 LLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           +L +         +  D      ++ + IAI+  KL +       + +++  + + + A 
Sbjct: 241 VLMNANFGNHIVRMYGDYDKMRKLASLVIAIDPKKLGNP-VFAKTMAKMVTELHAVKPAP 299

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +  P         + ++ GI V   ++  +  
Sbjct: 300 GVEKVLAPNDPQMHYKEKCQQEGIPVPAGIFHYLAE 335


>UniRef50_A6VRA6 Malate/L-lactate dehydrogenase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VRA6_MARMS
          Length = 349

 Score =  313 bits (802), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 72/341 (21%), Positives = 148/341 (43%), Gaps = 15/341 (4%)

Query: 1   MKVTF---EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE 57
           MK T+    +LK+   ++L   G+  + A   AE+  ++ E G  +HG++  P +I +L+
Sbjct: 1   MKFTYFNRNELKSLGTKLLSQYGMPDDRASITAELLIQSDELGFTTHGLSLIPYYIPELQ 60

Query: 58  NGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHW 117
            G +        +   G+   W+AQ   G     K MD A     +HG+   ++  A+H 
Sbjct: 61  AGKMQEADDVVVVNDTGSTFVWNAQYLPGIWMMNKAMDEAFSRVKEHGVVTASINRAHHI 120

Query: 118 MRGGSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPS-TPITMVDMS 174
               +Y   A +K  I I  T+  A  ++ P+G  +  +  NP  +  P+     ++D  
Sbjct: 121 GCLSTYVKLATDKNLICIVSTSDPAGKLVAPFGGIDPVLTPNPWAIGYPTNGDPVIIDTV 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMS 230
            S+ ++  +  +   G  +P     D  GN T +  VI     ILP+G      +G   S
Sbjct: 181 TSICTFSKVREHLNTGLPMPYPMLQDKNGNETTDATVINDGGAILPIGGTDYGHRGYCFS 240

Query: 231 IVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTS 290
           I+++M+   LS      +V++        +     I+ +          ++ ++ +   +
Sbjct: 241 IMVEMLTQGLSGHGRADDVSRWGG-----NVYIQLIDPEAFAGLEAFKEQMDKLTELCLA 295

Query: 291 AERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           +   +E + +R+PG    +   +++  GI ++D    +++ 
Sbjct: 296 SRPREEGKPVRVPGQFGLSCAKQSKTQGIRLNDETLDRLKQ 336


>UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus
           DSM 43160 RepID=D2SD16_9ACTO
          Length = 732

 Score =  312 bits (799), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 87/345 (25%), Positives = 153/345 (44%), Gaps = 13/345 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V  + L+     VL + GV    A   A + A    SG+ SHG+ R P ++  + NG 
Sbjct: 374 VRVPADVLETWTAEVLEAVGVRPSHARDTARVLAYADLSGIDSHGIARLPAYVGAIGNGV 433

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D +P   +   A+   D    +G+       D A+  A  +G+G V +R ++H    
Sbjct: 434 IAVDGRPSVHSDGSAVALVDGHDLLGHPVTTFAFDEAVARARRYGVGWVNVRRSSHHGAS 493

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVA--IPSTPITMVDMSMSMF 178
           G Y + AA  G +G+  TN+  V+ P GA    +GTNPL +   +P     + DM+ S  
Sbjct: 494 GCYVYDAARLGLVGLAATNTGPVVAPAGAARPYLGTNPLALGVPVPGEEPLVFDMATSAV 553

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMG------YWKGSGMSI 231
           + G  E+    G+ +P+  G D EG  T +P  +      +LP+G        KG G+ +
Sbjct: 554 AAGKFEIALRLGKPVPLGWGVDAEGRPTTDPAAVFPGRGALLPLGSDRERSSHKGYGLGL 613

Query: 232 VLDMIATLLSDGASVAEVT----QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           +++++  +L+ G +   V     +  +     S + + ++  +L D         R++  
Sbjct: 614 LVELLTAVLAGGPTGPGVGNLTFRSGARSPDTSHLVVVLDPARLGDPEAIGGGAARLLAE 673

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +      D +  +R PG       A  R  G+ +D      +QAL
Sbjct: 674 LRGLAPVDPDLPVRTPGQRAAAERALRRELGVPLDAETHRALQAL 718


>UniRef50_B1K2F1 Malate/L-lactate dehydrogenase n=7 Tax=Proteobacteria
           RepID=B1K2F1_BURCC
          Length = 349

 Score =  310 bits (796), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 81/334 (24%), Positives = 142/334 (42%), Gaps = 6/334 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V+   L       L + G+    A   A +       G+ +HG +R   +  +L  G I 
Sbjct: 11  VSKAHLTELTIEALCALGLTRTDATDTATILVLADLFGLRTHGTSRIESYGSRLRIGGIN 70

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P           A+ + D    IG L   + +D A+  A + GI  V +R +NH+     
Sbjct: 71  PAPSITTEQVAPALYRLDGDNGIGPLVGHRALDLAMTAAREQGIACVFVRGSNHFGPVSP 130

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFSY 180
           Y + AA +G+  I  +N+   + PWG  + R+G +P+   +  P+    M+DM++S+ + 
Sbjct: 131 YSYLAAMQGFASIIGSNATTTIAPWGGTDARLGNSPVGFGVPNPNGRPFMLDMAISVAAR 190

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +      G  +P D   D +G  T +P        +LP+G  KG G+++V+D+ A LL
Sbjct: 191 AKIRNALKRGEPIPGDWATDAQGKPTTDPKAALD-GFLLPIGGHKGYGLALVVDLFAGLL 249

Query: 241 SDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           S  A +  V     D      +   FI I+  +L       A++      +  ++ AD  
Sbjct: 250 SGAAYLTHVKSWEDDPEQPQNLGHFFILIDTTRLGSTGWLAARMADYAAILHGSQPADPE 309

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + +PG      L      GI +  +  A ++A
Sbjct: 310 APVIVPGEIELGRLERQMAEGIDIGAAQLAMLEA 343


>UniRef50_C1C568 MIP04978p (Fragment) n=10 Tax=Drosophila RepID=C1C568_DROME
          Length = 399

 Score =  310 bits (795), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 69/310 (22%), Positives = 130/310 (41%), Gaps = 3/310 (0%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  ++ +      L+  GV        +E        G Y  G+NR   ++  L++G   
Sbjct: 48  VLVDEARRFIQDCLLRVGVSPSKVRCISEFLVVADYRGNYGSGLNRLDYYLSDLQSGHAK 107

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+P  I+   +    +   ++G       MD A++ A D GIG V  + ++       
Sbjct: 108 VGAEPSIISETVSTAHVNGNSALGVFVGNFCMDLAVKKAEDSGIGFVVAQQSHDIGMASW 167

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYG 181
           + ++AA KG  GI  +NS   M    +K   IG+N     +       ++DM+ S+   G
Sbjct: 168 FTFRAAGKGLAGIVMSNSAPTMMGPNSKSASIGSNCFAFCVKGEEYHFVLDMATSVKDIG 227

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +E        +P     ++ G  T  P +  +   + P G  KG  +S V+D++  +LS
Sbjct: 228 AVEWAWANDEYIPHGWAANEGGLSTCFPSLALRTPLLFPAGGHKGYCLSAVIDILCGVLS 287

Query: 242 DGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
                  +T D +    + Q+FIA++ +  +       +       + +++ AD+++ IR
Sbjct: 288 GAQYATHITMDQNQPSNLGQVFIALDPEFFLP--NFMERFDDFCGRIQNSQPADDSEPIR 345

Query: 302 LPGHEFTTLL 311
           LPG      +
Sbjct: 346 LPGELERMHM 355


>UniRef50_C0CRX3 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CRX3_9FIRM
          Length = 356

 Score =  310 bits (794), Expect = 6e-83,   Method: Composition-based stats.
 Identities = 78/335 (23%), Positives = 138/335 (41%), Gaps = 8/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   +LK    ++ ++ G+    A A +E+        V SHGV R   ++++++ G   
Sbjct: 6   VDSGKLKEYTTKLFLAAGLAQTDAQAVSELLVHADLRNVRSHGVLRTVPYLEKIQKGGAS 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             +    +         DAQ  +G L  +K +  A E A    + +V +RN+NH+  G  
Sbjct: 66  KTSAYPVVKETTNSAVIDAQGGLGALAGEKAVAIAREKAKTALMSMVVVRNSNHFGMGAH 125

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFS 179
           +  + A    IG   + +   M P G KE  +G NP  VA  +    P   VDM+ S  +
Sbjct: 126 WALKLAGNDMIGFACSTTDLTMGPPGCKEPFMGNNPFAVAFKAGEKYPEFCVDMATSGVA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G  +     G+ +P     D  GN T     +E    + PM   KG G+++++++ ATL
Sbjct: 186 LGKCKDLAKRGKPIPSGWMLDKNGNDTT---KVEDCYMMTPMAGHKGFGIALIVELFATL 242

Query: 240 LSDGASVAEVTQD--NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           LS G    ++            SQ F  I +    D        +  +D +      +  
Sbjct: 243 LSGGVLSPDINNQDLPDVPELSSQCFGCINISAFRDLAEFQETAENYIDRLHQIPMKEGA 302

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + PG    T    N + G+ + +++   + A+
Sbjct: 303 GDAKYPGEIEYTSKLINLKEGVVLPETLTEDLMAI 337


>UniRef50_B9K4F6 Malate dehydrogenase n=1 Tax=Agrobacterium vitis S4
           RepID=B9K4F6_AGRVS
          Length = 349

 Score =  308 bits (790), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 79/336 (23%), Positives = 143/336 (42%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++ FE L+    R+ ++ G     A+  +   A     G  SHG+ R P ++  + +G +
Sbjct: 13  RLPFEALQNLLKRIFLAAGASEHVANILSANCAGCERDGALSHGIFRMPGYVSSIRSGWV 72

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A P   T      + DA+     +          E A   GI L+++RN++H+    
Sbjct: 73  DPAAVPVLETGGSGFLRVDARNGFTQVALDFAAQSLKERARQEGIALLSIRNSHHFSALW 132

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
                 AE+  + I   NS A   P+ AK    GTNP+  A P       +VDM+ S  +
Sbjct: 133 PDVVPFAEERLLAIAMVNSFACTAPFDAKVPVFGTNPVAFAAPCDGMVPMVVDMATSAIA 192

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +++    G  LP   G D  G  T +P  +     +L  G +KGS +S+++++++  
Sbjct: 193 NGDVQIAAREGFSLPPGLGIDRSGKPTVDPHAVLDGGALLTFGGYKGSAISMLVEVMSAA 252

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+ G    EV       +      Q+ I I+ D          +++ +++ +  A+ +  
Sbjct: 253 LTGGKFSYEVDWSDYPGAQTPHTGQLVILIDPDV-GRNAQFSRRVRHLVERLRLAKVS-- 309

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG         + R G+ +  S   +++ L
Sbjct: 310 ----RLPGDRRLVTRERSMREGVCLQKSDLERMELL 341


>UniRef50_C5A802 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Burkholderia
           glumae BGR1 RepID=C5A802_BURGB
          Length = 357

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 83/335 (24%), Positives = 151/335 (45%), Gaps = 10/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E+L+       + RG+ +  A   A    RT+  G+ +HGV   P ++++L+ G   
Sbjct: 5   IQAERLRQLCETAALRRGLSATHAAWFAHGLVRTSLMGIDTHGVRLLPLYLRELDEGRSN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+   + +         DA  + G +        A ELA + G+G+VA+ N+NH+     
Sbjct: 65  PEPALRTVRRFQGTALVDADAAPGVVAGSHAARLASELARECGVGVVAVANSNHFGAASV 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSY 180
           YG   A +G IGI  T++ A M P+ A     GTNP+  A P+      ++DM+ S  SY
Sbjct: 125 YGEWIAAQGLIGIVTTSAAARMAPFNATRAMFGTNPICFAAPARDGDLYLLDMATSQISY 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             ++  R  G  LP       +G    +P  +     +  +G +KG G+++++ +++ LL
Sbjct: 185 SQVKHFRRNGMALPSGWALGADGQPVTDPAQVV---SLATLGGYKGQGLAMMVQILSCLL 241

Query: 241 SDGASVAEVTQDNSDEYG----ISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +       +T  +++ Y     I    IAI+  +        A +  +M  +     A+ 
Sbjct: 242 TAMPLDHALTHLDAEPYDRGREIGHCLIAIDPARFGSLDAFTAGVSSLMQAIRETPAAEG 301

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            + +++ G      +A     GI +DD  W  +QA
Sbjct: 302 -ERVQVAGDPQKAAIARRTAQGIPLDDDEWRGLQA 335


>UniRef50_C0CWH3 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CWH3_9CLOT
          Length = 337

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 139/333 (41%), Positives = 210/333 (63%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ FE++KA   +VL  RG   + A+  A   AR +  GVY+HG+NRF R I+ ++ G 
Sbjct: 4   VRLPFEEVKACLCQVLAGRGCPEKKAEKVAHEMARNSLEGVYTHGINRFARLIRNIDEGI 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P+    +GA+EQ D    +G   A   M+ A++LA  +GIGLVALRN NHWMR 
Sbjct: 64  VRPGAEPEVTVRMGAMEQVDGHLGLGITNAWFSMEEAVKLAKSYGIGLVALRNTNHWMRA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
            +YG+QA + G   +C+TN++  MP WGA + RIG NPL+ A P      + DM+MS FS
Sbjct: 124 ATYGYQACDAGMAAVCFTNTMPNMPTWGAVDSRIGNNPLVFAFPRREGHLITDMAMSQFS 183

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE+ RL GRQ+ +D GFD  GNLT++P  + K++RILP GYWKG+ +S +LD+ A +
Sbjct: 184 YGALELARLQGRQMAIDAGFDTAGNLTRDPDSVIKSQRILPTGYWKGAALSFMLDIFAGV 243

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LSDG +V+ V + + DE+G+SQ+FIA++   L+     +  ++  +  + ++ +A     
Sbjct: 244 LSDGNTVSGVGRLSGDEHGVSQVFIAVDYRNLVTQEAAERIVEGAVKDLLASGKAQGTDR 303

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           I   G       A+N +NGI VD+ VW +I +L
Sbjct: 304 IIYTGQLTLECRADNLKNGIPVDEGVWNEISSL 336


>UniRef50_Q07251 L-lactate dehydrogenase n=8 Tax=cellular organisms RepID=LDH_RALEH
          Length = 349

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 77/340 (22%), Positives = 144/340 (42%), Gaps = 10/340 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++    +     +L ++ V ++ AD  AE    +   G  SHG++  P +   L+   
Sbjct: 1   MKISLTSARQLARDILAAQQVPADIADDVAEHLVESDRCGYISHGLSILPNYRTALDGHS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  + K +   G +  +D     G    K +M  AIE    HG  +V LR ++H  R 
Sbjct: 61  VNPQGRAKCVLDQGTLMVFDGDGGFGQHVGKSVMQAAIERVRQHGHCIVTLRRSHHLGRM 120

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMS 174
           G YG  AA  G++ + +TN      V+ P+G +  R+ TNPL  A P     P  +VD++
Sbjct: 121 GHYGEMAAAAGFVLLSFTNVINRAPVVAPFGGRVARLTTNPLCFAGPMPNGRPPLVVDIA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGYWKGSGMSIV 232
            S  +     V    G   P       +GN T +   +       +LP G  KG  + +V
Sbjct: 181 TSAIAINKARVLAEKGEPAPEGSIIGADGNPTTDASTMFGEHPGALLPFGGHKGYALGVV 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A +LS G ++             +   + +     +    + A+++  + Y+    
Sbjct: 241 AELLAGVLSGGGTIQP-DNPRGGVATNNLFAVLLNPALDLGLDWQSAEVEAFVRYLHDTP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            A     ++ PG       A+   + + ++ ++W  ++ L
Sbjct: 300 PAPGVDRVQYPGEYEAANRAQAS-DTLNINPAIWRNLERL 338


>UniRef50_B5KEU8 Putative L-lactate dehydrogenase n=1 Tax=Octadecabacter antarcticus
           238 RepID=B5KEU8_9RHOB
          Length = 365

 Score =  306 bits (785), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 76/345 (22%), Positives = 149/345 (43%), Gaps = 15/345 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            T + +KA    +L++ G+ ++     AE        G+ +HG++    + +    G   
Sbjct: 6   YTPDSIKAQATEILVNWGMSADNVALTAEGMLDCDLRGIDTHGISLLALYDKWRVGGGFA 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA  K +    +    DAQ  +G   + + ++ A   A + G+  V +RN+ H+   G 
Sbjct: 66  LDATDKLLRDGPSYASIDAQGGLGFPVSVRAVELACNKARETGLAAVTVRNSRHFGAAGY 125

Query: 123 YGWQAAEKGYIGICWTNSI-AVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
           Y    AEKG + +  T++    M P GA +  +GTNPL  A+P       + DM+ S  +
Sbjct: 126 YARLGAEKGMMMLVATSTKVVCMVPPGAADAVLGTNPLAYAVPRQNGAPVVFDMATSTAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI------EKNRRILP------MGYWKGS 227
              + + +L+   +P     D EG    +P +        +   + P      MG +KG 
Sbjct: 186 GNKIRLYQLSNTPVPEGWVVDHEGKSVTDPDIASDIVYGSRPGGLTPLGATPGMGAYKGY 245

Query: 228 GMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDY 287
           G++++   +   L+ G       +       I   F+A++  K  D    +A +  + D 
Sbjct: 246 GLALMGHFLGGTLAGGDFAGSKNRAADASDNIGHFFLAMDPAKFRDLAAFEADMCDVDDS 305

Query: 288 VTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +    D ++ I LPG     +  + R+ GI + D++  +++ +
Sbjct: 306 LRATPAVDPDRPILLPGDVERKVADQRRKAGIPLADALVDQLKRI 350


>UniRef50_Q0K2P1 Malate/L-lactate dehydrogenase n=5 Tax=Burkholderiales
           RepID=Q0K2P1_RALEH
          Length = 367

 Score =  306 bits (784), Expect = 8e-82,   Method: Composition-based stats.
 Identities = 71/337 (21%), Positives = 142/337 (42%), Gaps = 10/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++    L      + ++ G  ++ A   A+       SG  SHGV   PR++   +  ++
Sbjct: 5   RIPTAALHQWVADLWLAAGSSAQEARLTADHLVGANLSGHDSHGVGMIPRYVLAWQADEL 64

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             + Q   +   G++   D  R +G     + M+ AI  A +HG+ ++ LR ++H  R G
Sbjct: 65  QLNQQVSVLHDAGSMLSLDGNRGMGQAVTAQAMNMAIGRAREHGVCVMGLRQSHHLGRVG 124

Query: 122 SYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSM 177
            +  QA   G I I + N  S  ++ P G  + R GTNP  + +P    P  ++D + S 
Sbjct: 125 HWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARYGTNPFTIGVPVAGEPPLVLDFATSA 184

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-----KNRRILPMGYWKGSGMSIV 232
            + G + V    G  +      D  G  + +P V+          + P G  KG  ++++
Sbjct: 185 IALGKVRVAHNKGVPVAPGCLLDAHGEPSADPAVMYPADGAPQGALRPFGEHKGHVLAVM 244

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++   ++ G ++   T  +      + + I  +  +L +  +   ++    D++ ++ 
Sbjct: 245 CELLGAAVTGGHTIRPETLRHEHAVWNNMLAIVFDPARLGNSTSFGHEVAAFADWMKASR 304

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
                  IRLPG       A    + + VD    A++
Sbjct: 305 LQPGQDGIRLPGEPERAWRAARATH-MPVDAGTLAQL 340


>UniRef50_A3SYU7 Malate/L-lactate dehydrogenase n=2 Tax=Sulfitobacter
           RepID=A3SYU7_9RHOB
          Length = 356

 Score =  305 bits (783), Expect = 9e-82,   Method: Composition-based stats.
 Identities = 86/339 (25%), Positives = 148/339 (43%), Gaps = 9/339 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V   +L      +L   G D+  A   A        +G  SHGV   P ++  +  G 
Sbjct: 1   MAVDAGRLTDFATAILAHAGQDAGRAAKVAARLVGANLAGHDSHGVGMIPAYVDGILAGQ 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A  + +   G     D  R  G++ A++ M  AI+ A  H    ++LRN+ H  R 
Sbjct: 61  LDAAADIELVQDKGPFLLVDGHRGFGHIVAEQAMTLAIDRAQAHHFATLSLRNSFHLGRL 120

Query: 121 GSYGWQAAEKGYIGICWTN---SIAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMS 174
           G +G  AAE G+I I + N   +  ++ P+G  + R  TNP   AIP+    P+ ++DM+
Sbjct: 121 GDWGIMAAEAGFICILYANVQSARPLVAPFGGSDARFVTNPYCTAIPATEKHPMFVLDMA 180

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMGYWKGSGMSIV 232
            S  + G   V +L+G+  P     D +GN T++P V+       +   G  KG G++++
Sbjct: 181 TSTIAMGKARVAQLSGKPAPEGALIDAQGNATRDPSVVFDGAGGALTAFGQHKGFGLALL 240

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            D++    S G + A   +        + + I I+ +      +    +    D+V ++ 
Sbjct: 241 GDILGGSFSGGGAYAPEREVPDRIVN-NMMAILIDPNVFGLAQSFGVDVDSYTDWVKASP 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            A     ++ PG       AE    GI +D    A++ A
Sbjct: 300 AAPGTAGVQFPGDPERRSTAERSAKGIPLDAGTLAQLTA 338


>UniRef50_C1DFD6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=C1DFD6_AZOVD
          Length = 372

 Score =  305 bits (781), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 83/346 (23%), Positives = 154/346 (44%), Gaps = 17/346 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           KV  + L+     VL + G+ +  A+  A +   T  +G+ SHGV+  P +    E G  
Sbjct: 8   KVGADALRELTAAVLAAWGMPAVAAEETAALIVETDLAGIDSHGVSMLPFYETLREAGGW 67

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           +PDA+P+ +         D    +G+ TA + M  A + A   G+G VA+RN+NH+   G
Sbjct: 68  VPDAEPRVVRESPCTALLDGGHGLGHRTAMQAMRLAADKAQGVGLGAVAVRNSNHFGAAG 127

Query: 122 SYGWQAAEKGYIGICWTNSI-AVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
            Y   AAE+G IG+  + +   ++ P  A+   +GTNP+  A P+      ++DM+ +  
Sbjct: 128 LYARAAAERGLIGLVASTTRSPMLVPTRARVPVLGTNPIAFAAPARRNRPFVLDMATTTV 187

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK------NRRILPMGY------WKG 226
           +   ++V  L G+ +P     D+ G          +         +  +G        KG
Sbjct: 188 AANKVKVYDLQGKDIPPGWVVDEAGRPVTAGERAMEYLFRRPEGGLTALGGVAELGSHKG 247

Query: 227 SGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
            G+ ++  ++A  L   A  A   ++  ++  I   F+A++     D    + +L  I+D
Sbjct: 248 YGLGMLAQILAGPLCGAAFGA--RREADEKPNIGHFFLALDPRAFRDADEFEDELDAIVD 305

Query: 287 YVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + +   AD    + + G           R GI + D + A+++ +
Sbjct: 306 ALHATPAADPALPVLVAGDPEAQTRETRLREGIPLPDRLQAQLREI 351


>UniRef50_A6C467 Malate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C467_9PLAN
          Length = 356

 Score =  303 bits (776), Expect = 6e-81,   Method: Composition-based stats.
 Identities = 78/335 (23%), Positives = 150/335 (44%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++    LK    ++ +  G+    A+  A+        G++SHG     R++  ++ GD
Sbjct: 16  VQIPLGPLKELLVKLFVRMGMFEVEAEIAADRLIEADLRGIHSHGSRTAERYLDSMDMGD 75

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P AQ   +    AI   D  +S+G++ A + M+ AI+ A + G G V ++N++H+   
Sbjct: 76  IDPRAQILTLKETPAIAVLDGSKSMGHVAATRAMELAIKKAGEVGTGTVVVKNSHHFGAA 135

Query: 121 GSYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSM 177
             Y   A + G IG C TN+  A +   G+ +     N +   +P+      ++DM+ + 
Sbjct: 136 AVYVLMAVKAGMIGYCTTNTGRATVAAHGSTQGATANNAIAWGVPTREGAPFVLDMACAK 195

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            S+G LE   + G  +P     D+EG  T +   +   + +LP    +G G+++V  ++ 
Sbjct: 196 TSWGKLETQAMYGLPVPPGYALDNEGKETTDSSTV---KTLLPAAGPRGYGLAMVSSILT 252

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             L+ G      T+    E G    F  I++ + ++     A+L   +  +      +EN
Sbjct: 253 GALAGGKLPINKTKPPEIE-GSEHFFYVIDLKQFVEEEHFHAELDSAIKAIHQLSTVNEN 311

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + +RLPG         +   G+ V       ++ L
Sbjct: 312 EPVRLPGELEWEQTQRSLSEGLLVHRDHANLLKEL 346


>UniRef50_C6XSR8 Malate/L-lactate dehydrogenase n=3 Tax=Bacteria RepID=C6XSR8_PEDHD
          Length = 327

 Score =  302 bits (775), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 144/331 (43%), Positives = 207/331 (62%), Gaps = 7/331 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++ F++LKA F RVL+      ETAD+CA +FA  +  GVYSHG+NRFP F++ ++ G 
Sbjct: 1   MRIPFQELKAEFKRVLLKLSFPPETADSCALVFAANSRDGVYSHGLNRFPVFVKLVQKGL 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P  +   GAIE+WD   + G   A   M RA+ELA  +GIG VA++N NHWMRG
Sbjct: 61  IKANALPALLERNGAIERWDGNFAPGMSNASHCMARAVELAKINGIGCVAIKNTNHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           G+YGWQAA+ G IGIC+TN+ A MP WG K+  +G NPL++AIP      ++DM+MS FS
Sbjct: 121 GTYGWQAADAGCIGICFTNATANMPAWGGKDPVLGNNPLVIAIPRKEGHVVLDMAMSQFS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG ++   L    LP  GG+D++GNL+ +P VI K +  LP+G+WKGSG+S+VLD++A  
Sbjct: 181 YGKMQEYELKNEALPFPGGYDEQGNLSTDPAVIRKTKLALPIGFWKGSGLSLVLDLLAVA 240

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           LS G S  +++   +DE G+SQ FIAI           DA +  ++ Y  ++E       
Sbjct: 241 LSGGNSTGKISAQ-ADETGVSQCFIAI-----RQPDMHDALIAEVLAYTKNSEAVKAGGQ 294

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
           +  PG        EN   GI V++ +W +++
Sbjct: 295 VSYPGERTLQTRLENEEKGIPVNEEIWMQVK 325


>UniRef50_B7VQB6 Hypothetical oxidoreductase n=2 Tax=Vibrio RepID=B7VQB6_VIBSL
          Length = 333

 Score =  302 bits (775), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 150/331 (45%), Positives = 218/331 (65%), Gaps = 2/331 (0%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V+ E+L+  + R+L++R +  E A   A  F      G YSHG+NRFP FI Q++ G I 
Sbjct: 4   VSTEKLQQEYERILLARDMKPEMATKLAAGFVEMANEGTYSHGINRFPVFIDQVDKGQIK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            +A+P+ + S+GA+EQWD     G L      +RA+ELA D+GIG+V +RN+NHWMRGG+
Sbjct: 64  LNAEPECVNSMGALEQWDCNYGPGVLNGLICAERAMELARDYGIGMVGMRNSNHWMRGGA 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM 182
           Y  + A +G+ GI  TNSIAVMP WG K+ R+G+NPLI+A+   P  +VD SMS FSYG 
Sbjct: 124 YVLKMAREGFAGIASTNSIAVMPAWGGKDHRVGSNPLIMAVAGDPPVVVDCSMSQFSYGQ 183

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           L+   LA ++LPV GGFD+EG LTK+P V+ +N+R+LPMG+WKGS M+IVLDM+ T ++ 
Sbjct: 184 LQNFVLADKELPVVGGFDNEGELTKDPHVLWENKRLLPMGFWKGSSMAIVLDMMLTAITG 243

Query: 243 GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRL 302
           G SV  +T+D   E+G+SQ  IAI++ K +D  T   +++RI DYV  +E A+   ++ +
Sbjct: 244 GHSVPALTEDMGGEFGVSQFLIAIDLSKTMDQSTYAQEMKRIRDYVLESEPAE-TGSVMI 302

Query: 303 PG-HEFTTLLAENRRNGITVDDSVWAKIQAL 332
            G      +       GI ++D +W +I +L
Sbjct: 303 AGSEIENFIKKHEAAGGIEINDGIWEQITSL 333


>UniRef50_B5Y2B5 Malate/L-lactate dehydrogenase family protein n=5 Tax=Klebsiella
           RepID=B5Y2B5_KLEP3
          Length = 336

 Score =  302 bits (775), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 80/337 (23%), Positives = 150/337 (44%), Gaps = 11/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + ++  +       VL + G  ++ A A A         G  SHG+ R    +  L  G 
Sbjct: 4   VTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PDA+P+      AI + DA  +   L  ++ +   +E A  +GI  +A+    H+   
Sbjct: 64  VSPDAEPQIHDQAPAIARADAGGAFSLLAYERALPLLLEKARQNGIAALAINRCVHFSAL 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
            +      E G +G+  T S A + P G      GTNP+    P       +VDM+ S  
Sbjct: 124 FADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTNPIAFGWPRRDKQPFIVDMATSAA 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +++++ AG+ LP   G D +G  T +   +  N  +L  G  KGS ++ +++++A 
Sbjct: 184 ARGEIQLHQRAGKALPQGWGIDSQGQPTTDAAEVL-NGAMLTFGGHKGSALAAMVELLAG 242

Query: 239 LLSDGASVAEVTQDNSDEYGI---SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L    + AE    ++   G+    ++ +A++  + +      A+ Q  +    +   A 
Sbjct: 243 PLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLG-----AQAQEQLARAETLFNAM 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++Q  RLPG        ++ + G+T+  S+  +I AL
Sbjct: 298 QDQGARLPGERRFACRQQSEQQGVTISRSLHDEICAL 334


>UniRef50_B8IDJ1 Malate/L-lactate dehydrogenase n=6 Tax=Alphaproteobacteria
           RepID=B8IDJ1_METNO
          Length = 378

 Score =  302 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 79/346 (22%), Positives = 140/346 (40%), Gaps = 21/346 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M +    L A    + +  G  +E A            +G  SHGV R PR++  L  G+
Sbjct: 21  MLIAAAGLTAFVRDIFVGEGCSAEEAGRIGRYLVAANLTGHDSHGVIRVPRYVGWLRAGE 80

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++ D  P+ ++   A    DA    G        +  I  A  +G+ +VALR+A H  R 
Sbjct: 81  VVADRAPEVVSDSAAFVLVDAHYGFGQTAGPFATELGIARARQNGVAIVALRHAGHLGRI 140

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMS 176
           G +  QAA  G + + + N     ++ P+G+ + R  T P     P       ++D + S
Sbjct: 141 GEWAEQAAAAGLVSVHFVNVAGSLLVAPFGSVDRRFSTAPFAAGFPVAGAEPIILDFATS 200

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-------------RRILPMGY 223
             + G + V    G+ LP     + +G L+++P  +                  I   G 
Sbjct: 201 AVAEGKVLVASQGGKPLPEGVLIEPDGRLSRDPRTLFGPIEGTAERDSRRGEGAIRAFGE 260

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KGSG++++ ++IA  L+   +           +    + I +  +    G    A+ + 
Sbjct: 261 HKGSGLALMCELIAGALTGSGTAGP----GPKRFCNGMLSIYLTPEAFGSGDAIAAETRT 316

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +D+  SA  A  +  + LPG       A+    G+ + D VWA +
Sbjct: 317 YLDFFKSARPASPDGEVLLPGEPERRTRAQRLAEGVPLPDPVWATL 362


>UniRef50_Q0ART3 Malate/L-lactate dehydrogenase n=1 Tax=Maricaulis maris MCS10
           RepID=Q0ART3_MARMM
          Length = 355

 Score =  301 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 77/339 (22%), Positives = 139/339 (41%), Gaps = 10/339 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++    L A    VL+  G   + A+  A         G  SHGV   P +   +  G +
Sbjct: 7   RLDAPNLTAFCTAVLVRAGARVDDAECVARHLVEANLKGHDSHGVGILPAYAGHIRRGQV 66

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             DA    +T    + + DA    G    ++++ +A   A   G+    L NA+H  R G
Sbjct: 67  CLDADDTVLTDTTVLLRVDAGGGWGAPAGQRLIHQAGAKAKSGGLAAATLGNAHHLGRIG 126

Query: 122 SYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDMSM 175
           +Y  QA+E G I + + N      ++ P+   + R GTNP+ +  P+    P  ++D++ 
Sbjct: 127 AYAEQASEAGLISMHFVNVTDHAPLVAPYRGSDARFGTNPVCIGFPATDTRPAFLLDIAT 186

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI---EKNRRILPMGYWKGSGMSIV 232
           S  + G   V    G  +P     D +G  T +P  +   E    + P+G  KG G++  
Sbjct: 187 SQIALGKARVAANKGLPVPAGSLIDKQGRPTTDPSGMSGFEIEGALTPLGKHKGYGLAFA 246

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
            +++A +L    ++       S     S   I I+ D   D     A+   +  Y  ++ 
Sbjct: 247 CELLAGVLGGAGTIQP-DHPRSGGLKNSMFSILIDPDAFGDRAWMQAETDAMARYALASP 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             D +  +  PG     +  +  + GI +D+    ++ A
Sbjct: 306 PMDWDSPVLYPGDPERAIAGKRGKEGIPLDEVTIGQLNA 344


>UniRef50_B4LXJ0 GJ23783 n=1 Tax=Drosophila virilis RepID=B4LXJ0_DROVI
          Length = 520

 Score =  300 bits (769), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 139/336 (41%), Gaps = 12/336 (3%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           + +   + V  +  V  + A   A+        G  S G++R P     L N  + P  Q
Sbjct: 171 EAQRFVSDVFAAMDVPDDAASEMADALIAADYMGQRSMGIHRLPAIAADLLNLTVDPRMQ 230

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           PK ++   A+   D Q + G + A   MD AI  A + GIG VA R +N       Y  Q
Sbjct: 231 PKLVSERDALALVDGQNAPGPVVANFCMDLAIRKARNQGIGYVAARRSNTIGMASWYTCQ 290

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFSYGMLEV 185
           A     IGIC +N   ++ P G  E  +G N +  A  S     ++D+ MS +    L++
Sbjct: 291 ALSHRMIGICMSNGPPILVPCGGSEPLLGGNSIACAAGSKQEQFLMDLGMSAYPIEQLQL 350

Query: 186 NRLAG--RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIATLLSD 242
               G  RQLP     D  G  T       + +R+ P     K  G++ ++D++  +++ 
Sbjct: 351 EYSNGYLRQLPDYLALDSSGKPTNCAAEALRAQRLRPFTPEHKAFGLAAMVDILCGVMTG 410

Query: 243 GASVAEVTQD-----NSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            +    +        ++    + Q++IAI+  +     + + +L      + +    D  
Sbjct: 411 ASYATHIRHRSLFSSDNKLADLGQVYIAIDPMRF--CVSFEERLADFHQLLRNVIPCDPM 468

Query: 298 QAIRLPGHEFTTLLA-ENRRNGITVDDSVWAKIQAL 332
           Q   +PG +    +   + + G+ +  S  + IQ L
Sbjct: 469 QPPLIPGDKELQHMQMVDDQGGLMLSPSTLSVIQEL 504


>UniRef50_B6BPN1 Ureidoglycolate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B6BPN1_9RICK
          Length = 332

 Score =  299 bits (767), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 71/337 (21%), Positives = 146/337 (43%), Gaps = 14/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T +++     + L++ G + ETA   +E+       G  SHG+ R P ++  L++G 
Sbjct: 4   VSLTLDEIFNLAKKTLVANGCNDETASILSELIKNAERDGSLSHGLFRLPAYVSGLKSGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I     P+      ++ + +    +  +   K +    + A ++G+ ++A+ N++H    
Sbjct: 64  INGKGTPEVKRISPSVIKIEGNNCLAPVVLNKGLPELAKAAKENGVAVLAINNSHHMAAM 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMF 178
                + AE G +    T+    + P GA +   GTNP+  A   P     + DM+ +  
Sbjct: 124 WPETEKLAEDGLVAFACTSYKPAVAPAGAIKPLFGTNPISFAWPRPGKTPVVYDMATASM 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G ++V +  G ++P+  G   +G  T +PG I     +LP G +KGS ++++++++A 
Sbjct: 184 AMGEVQVAKREGHKVPLGTGLTKDGKETTDPGEIADGGVLLPFGGYKGSAIAMMVELMAG 243

Query: 239 LLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L       E      ++       +  +AI  DK   G +         D + S     
Sbjct: 244 ALVGDNFSYETAEKDNNDGGPPSGGEFILAICPDK-TAGTSWQKHSDEFFDKMKSM---- 298

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +RLPG        +       +++ +  KI++L
Sbjct: 299 --GDVRLPGERRHKNRQDTGPR--NINEELVNKIKSL 331


>UniRef50_Q9I492 Uncharacterized oxidoreductase PA1252 n=110 Tax=cellular organisms
           RepID=Y1252_PSEAE
          Length = 334

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 68/339 (20%), Positives = 139/339 (41%), Gaps = 15/339 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++++    R+L           A A+           SHG+ R    I  L+ G 
Sbjct: 2   IRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGK 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA+P+       + + DA         +  +   +E A   GI  +A+    H+   
Sbjct: 62  VSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHFSAL 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
                   E G + +  T S A + P G ++   GTNP+    P    P  + D + S  
Sbjct: 122 WVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFATSAV 181

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G ++++  AG+ +P+  G D++G  T +     +   +L  G  KGS ++ +++++A 
Sbjct: 182 ARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALR-GAMLTFGGHKGSALAAMVELLAG 240

Query: 239 LLSDGASVAEVTQDNSDEYG---ISQIFIAIEVDKL--IDGPTRDAKLQRIMDYVTSAER 293
            L    + AE    +          ++ IAI+  ++         A+ + + + +     
Sbjct: 241 PLIGDLTSAESLAYDEGSRSSPYGGELLIAIDPRRMLGASAEEHLARAETLFEGIVE--- 297

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               Q  RLP          + R+G+T+ +++  ++ AL
Sbjct: 298 ----QGARLPSQRRFEARERSARDGVTIPEALHRELLAL 332


>UniRef50_A4YFT2 L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=8
           Tax=Sulfolobaceae RepID=A4YFT2_METS5
          Length = 328

 Score =  297 bits (760), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 77/331 (23%), Positives = 136/331 (41%), Gaps = 22/331 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V+ E+LK+    +L  R V  E ++  A+        G  SHGV R    ++ +E G 
Sbjct: 7   MNVSAEELKSIIVEILNEREV--EGSEVIADHMVEAELRGHSSHGVQRLIPLVKGVELGT 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   +         D + S+G +   +     I+   D    ++A++NA+H    
Sbjct: 65  ISRRLQYDVLKKERGSMWIDGKHSVGIVLWNQ----LIQHEFDEPSSVIAVKNASHIGFL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           G Y  + A +GY+GI + N+   +   G     + T PL + IP  P  ++DM++S  S 
Sbjct: 121 GYYTDKLATRGYVGIMFGNAEPAVVLPGTSRKLLSTTPLSIGIPHAPPIVLDMALSSTSR 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   +  G  +P     D EG  T +P +  +   ILP+G  +G  + +VL+++ + +
Sbjct: 181 GKILEAQRKGEPIPEGWAVDSEGKPTTDPELALRGG-ILPIGGIRGFYLMLVLEILTSFI 239

Query: 241 SDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           S  A    V    +  +     +I I I                   + +    +    +
Sbjct: 240 SGSAMGPNVKGVLNTENPPNKGEILIVINPFYFAS----------YTEQIDEIRKLLGME 289

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
               PG     L A     GI +D  +W+ +
Sbjct: 290 ---FPGEHGLQLKARRLTEGIPIDAQLWSTL 317


>UniRef50_C5SZX1 Malate/L-lactate dehydrogenase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5SZX1_ACIDE
          Length = 376

 Score =  296 bits (759), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 78/351 (22%), Positives = 148/351 (42%), Gaps = 20/351 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + T E L+A    +L + G+   TA   A +   T   GV SHG++   ++    + G +
Sbjct: 7   RFTAESLRAQTAAILQAWGMPETTAHTTAALMVETDLLGVESHGISMLAQYEAMRDGGRL 66

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+ +    A    D    +G+  + + M  A++ A   GI LV +RN++H+   G
Sbjct: 67  HLAASPRVLRDGPATALLDGDAGLGHAVSAQAMQLAVDKARALGIALVGVRNSHHFGAAG 126

Query: 122 SYGWQAAEKGYIGICWTNSIA-VMPPWGAKECRIGTNPLIVAIP-----STPITMVDMSM 175
            Y   A  +G IG+  +++   ++ P  A E  +GTNP+  A P          ++DM+ 
Sbjct: 127 VYARIAQRQGLIGLVTSSAQGILLVPTRAAEPVLGTNPIAFAAPVSQGSHNNAFVLDMAT 186

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE------KNRRILPMGY------ 223
           +  +   ++V  L    +P     D +     EP           +  + P+G       
Sbjct: 187 TTAAANRVKVKALRSEPVPSGWVVDGQSQPVTEPEAARAQVFDQPDGGLTPLGGSSDGGS 246

Query: 224 WKGSGMSIVLDMIATLLSDGASVA--EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKL 281
            KG G++++  ++   L+ GA       +    D   +   FIAI+     +    + +L
Sbjct: 247 HKGYGLALLAQVLGGTLNGGAFAPLYRQSHGPGDPANVGHSFIAIDPRFFGEPGAFEHEL 306

Query: 282 QRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             I+D + +   A+  + + + G       AE  R GI +   +  +I+ +
Sbjct: 307 DAILDVLHATRPANPAEPVLVRGDPEAAQHAERARLGIPLPAPLLRQIRDI 357


>UniRef50_D1XHT9 Malate/L-lactate dehydrogenase n=1 Tax=Streptomyces sp. ACTE
           RepID=D1XHT9_9ACTO
          Length = 360

 Score =  296 bits (759), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 82/331 (24%), Positives = 138/331 (41%), Gaps = 7/331 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V    L      +L   G+ +E A   A++F      GV SHG  R P +++ L  G   
Sbjct: 14  VAAGDLLDFAAALLEKGGLCAEDARTTADVFVWAARRGVDSHGTARVPAYLELLAKGVAN 73

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
              +    ++  A    DA R+ G +   +    A++ A  +GI  V +R   H    G 
Sbjct: 74  ARPEITVESTTPAAAVLDADRAPGPVALTRAAREAVDRARTYGIATVGVRRTVHTGAIGY 133

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           Y  + AE+G +GI + + +  M   GAK   + T+PL VA+P       ++DM+ +  + 
Sbjct: 134 YVSRIAEQGLVGIGFVSGMPNMGYTGAKGAAVATSPLAVAVPATGHAPLLLDMATATIAL 193

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   +  G  LP       +G  T +P         LP+G  KGSGMS+  +++ ++L
Sbjct: 194 GKIRQAKADGTPLPEGAAATRDGTPTTDPERAVMP---LPLGGVKGSGMSLAFELLTSVL 250

Query: 241 SDGASVAEVTQDNSDEYGISQ--IFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
                 +    D+       Q  + IA++             +   +  + +   AD+  
Sbjct: 251 VGAPIFSSFHSDDPQGRTHRQNALLIAVDPAAFGGAEAFTEAVDTTLSTLKALPVADDAS 310

Query: 299 AIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +  PG     L AE  R GI V   VW ++
Sbjct: 311 GVFYPGERSAALSAERGRTGIPVAPKVWREL 341


>UniRef50_Q0SCF8 Possible (R)-2-hydroxyacid dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0SCF8_RHOSR
          Length = 358

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 79/335 (23%), Positives = 136/335 (40%), Gaps = 9/335 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  ++ +   +  L+  GV  + AD  A     T+  G+ +HG+   P+++ +L  G   
Sbjct: 12  IDEQEARWLASTALVEAGVPEDDADLVAAALVDTSLRGIDTHGLRLLPQYLDELATGVAN 71

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A P  +   GA    DA  ++G L        A + A   G+  V +RN+NH+     
Sbjct: 72  AAACPTVVRDRGAGLLLDADGALGVLAGLAATRLAADRAKAFGVAAVGVRNSNHFGAASV 131

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYG 181
           Y    A +G IGI  T++ + + P+G  E   GTNP+ VA         +DM+ S   +G
Sbjct: 132 YTRHLAGQGMIGIAVTSAASRVAPYGGVEPLFGTNPISVAAGTGDDGLALDMATSQVCFG 191

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            ++  R  GR L      D  G  T EP        + P+G +KG G+++ + ++  +L+
Sbjct: 192 EVKHRRAEGRPLGSGWATDRGGLPTAEPDEAY---ALSPLGGYKGQGLAMAVTLLGAVLT 248

Query: 242 DGASVAEV----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                 ++            G+    +A++           A L  ++D V  +  A   
Sbjct: 249 GSPPDWQLEQVGEGTPGRSRGVGHFVLALDPGAFSGHAHFAAGLADLLDTVRGSTPATGT 308

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  PG        E R  GI +D         L
Sbjct: 309 -PVVAPGDPQRAHERERRVRGIPLDPRTAEIFATL 342


>UniRef50_Q29EA1 GA15088 n=4 Tax=Sophophora RepID=Q29EA1_DROPS
          Length = 384

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 71/336 (21%), Positives = 134/336 (39%), Gaps = 8/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  E+ +      L   GV        +E        G+Y  G+++   ++  L +    
Sbjct: 35  VHVEEARRFIRDCLKRIGVPELKLRCVSEFLVAADYRGIYGSGLSQLDIYLNDLLHRRAN 94

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+ I    A    +   ++G +     M  A+E A + G+G V    +N+      
Sbjct: 95  MDAEPEIIRETVATAHVNGNDALGVIVGNFCMSLALEKAKNVGVGFVVANRSNNLGIASW 154

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYG 181
           Y  QA ++ Y G+  +N   +M P  +    IG N L   +       M+DM  SM   G
Sbjct: 155 YALQALDQDYAGLVMSNGAPIMVPPRSSVASIGANCLAFGVKGRNSYFMLDMVSSMKDIG 214

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            +E        +P     D+ G  T  P +  +N R+   G  KG  ++ ++D++  +LS
Sbjct: 215 SIEWALTKHEYIPHLWAADERGYSTCFPMLALRNPRLTCAGASKGYCLAAMIDLLCGVLS 274

Query: 242 DGASVAEVTQDNSD----EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
                 ++    S+       + QIFI I+ D  +       +L    + + ++  A   
Sbjct: 275 GANFSTQIPPWRSNVKRLCPNLGQIFIVIDPDFFLP--DFMDRLDDFTECIKNSTPASLA 332

Query: 298 QAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
           + I++PG      +    + G +   +++  K  A+
Sbjct: 333 KPIQMPGDREMRHMHLVEKLGALPYHNALLKKYNAI 368


>UniRef50_B1C3W7 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C3W7_9FIRM
          Length = 317

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 81/310 (26%), Positives = 136/310 (43%), Gaps = 9/310 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
             F + K      L   G+D   A+  A+ FA     GV SHG       I++L+ G   
Sbjct: 5   FDFYKEKKKVITELTKHGLDEIQAEVVADCFATADLYGVTSHGCAMTQAHIKRLKCGGYN 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                K +    A    D   S G ++A   ++ AI+   D G+  V  RN N +     
Sbjct: 65  LKPDFKIMRETDAFAVVDGDNSFGPVSAMFCLNLAIKRCKDSGVYTVFSRNNNTFGPAFY 124

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFSY 180
           Y  +AAE+GYI    +NS A M P G KE  +GTNP  V I  P     ++DM+ S+ + 
Sbjct: 125 YSLKAAEQGYIAFICSNSPAQMAPIGGKEKMLGTNPFAVVIPVPGHDPVIIDMATSVVAK 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
              +  + AG+ LP     D +G  T  P    +   +LPM  +KG G+++++D+++ +L
Sbjct: 185 SKFKQYKEAGKLLPNGWALDKDGKPTNAPDEGIQ-GMVLPMAGFKGYGIAMLIDIMSGVL 243

Query: 241 SDGAS---VAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           S  A    V     ++     +      I+   +      D  +   ++ + +++   + 
Sbjct: 244 SGAAYLNKVGRFYSEDGSGMNVGFYMTVIDPVAV--LEEYDEIITDFINRLKTSKPGVDG 301

Query: 298 QAIRLPGHEF 307
           + I LPG + 
Sbjct: 302 K-IILPGDDR 310


>UniRef50_Q46VE5 (R)-2-hydroxyacid dehydrogenase n=7 Tax=Proteobacteria
           RepID=Q46VE5_RALEJ
          Length = 338

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 78/336 (23%), Positives = 147/336 (43%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  E+L+      L   G     + A A    R    G+ SHGV+R P ++  L +  +
Sbjct: 3   RIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P   ++  +    DA         +  +  A+  A + G+G+ A+ N++H+   G
Sbjct: 63  DGQAVPTVRSTRASAVLVDAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 A  G +GI   NS A MP WG K    GTNP+  A P       ++D+S+S  +
Sbjct: 123 LPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIAAAFPRQGRLPVLIDLSLSEVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T 
Sbjct: 183 RGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALR-GSMLPAGGVKGAMLALMVELLVTT 241

Query: 240 LSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+     AE      D  +   I Q+F+ ++            +++ ++  +        
Sbjct: 242 LAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLD------ 295

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +   RLPG     L  E +++GI + ++  A++ +L
Sbjct: 296 DTGTRLPGARRYALQTEAQQHGIEIPEAQLAELLSL 331


>UniRef50_B0UBJ7 Malate/L-lactate dehydrogenase n=5 Tax=Bacteria RepID=B0UBJ7_METS4
          Length = 351

 Score =  295 bits (755), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 86/313 (27%), Positives = 147/313 (46%), Gaps = 5/313 (1%)

Query: 24  ETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQR 83
           + A  CA+   +    G  SHG+ R   +  +L  G   P A P+ +   G +   D + 
Sbjct: 27  QDAALCADSLVQADLWGHQSHGMMRLSWYAARLAAGVCDPRAVPESVVDAGGLAVIDGRE 86

Query: 84  SIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAV 143
           ++G + A + M  A+  AA HGIG VA+RN+NH+     +   AA  G IG   TN+   
Sbjct: 87  AMGQVVAAQAMAEAMARAAAHGIGAVAVRNSNHFGTAMYFTLMAARAGCIGFLSTNASPA 146

Query: 144 MPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDD 201
           M PWG +   +G NP   A P+      ++D++ +  + G + + R  G  +P+    D 
Sbjct: 147 MAPWGGRRKALGNNPWSWAAPAGRHAPLVLDIANTAVARGKIYLARQRGEAIPLGWAMDA 206

Query: 202 EGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQD--NSDEYGI 259
            G  T +P        ILPM   KGS +S V+D+++ +L+  A  A V          G 
Sbjct: 207 SGRPTADPQAAID-GLILPMAGHKGSAISAVMDVLSGVLTGSAFGAGVAGPYQAERRSGA 265

Query: 260 SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGI 319
             + +AI++ ++      +A+++R +  + +   A+  +A+  PG       AEN R G+
Sbjct: 266 GHLALAIDIARIQPLAEFEARMERFIAEMRAVPLAEGAEAVFYPGEIEARAEAENLREGV 325

Query: 320 TVDDSVWAKIQAL 332
            + +   A +  L
Sbjct: 326 LLPEDTRADLLRL 338


>UniRef50_B7UPM1 Predicted dehydrogenase n=13 Tax=Enterobacteriaceae
           RepID=B7UPM1_ECO27
          Length = 357

 Score =  295 bits (755), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 90/334 (26%), Positives = 155/334 (46%), Gaps = 12/334 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++  E+++     +L   G D++ A   AE        G  SHGV   P++++ +  GD
Sbjct: 3   LQIAVEKVRWLAAGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGD 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  +A+P+ +TS G ++++ A    G    K  ++ AIE     G  L+ L +A+H  R 
Sbjct: 63  VTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQTKHRGFCLLTLCHAHHLGRM 122

Query: 121 GSYGWQAAEKGYIGICWTNS---IAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMS 174
           G YG   A++G   +  +N     A++ PWG  E R+ TNP   A P     P  +VD +
Sbjct: 123 GHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFA 182

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGYWKGSGMSIV 232
            S  +     V    G+Q       D +GN + +PGV+       +LP G  KG G++++
Sbjct: 183 TSSMALNKARVMSSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALM 242

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++M+A +LS G ++AE  Q +   +      + I+ D+  D      K Q   DY+ + +
Sbjct: 243 IEMMAGILSGGDTIAEDHQTDGSAHNH-LFALIIDPDQFTDLAG--EKGQFFADYLLATQ 299

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVW 326
                  +  PG         N +  IT+  S W
Sbjct: 300 PQPGGNPVIYPGMPEAANRERNAKM-ITIPVSFW 332


>UniRef50_B6IQH9 Malate/L-lactate dehydrogenase family protein n=3
           Tax=Alphaproteobacteria RepID=B6IQH9_RHOCS
          Length = 339

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 73/337 (21%), Positives = 146/337 (43%), Gaps = 13/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T ++ +      L++     +TA A A    +    G   HG++R P +  Q  NG 
Sbjct: 6   IRMTLQEAEGLAMDALVACRTSPDTARATARALVQAEADGQKGHGLSRVPCYAAQSRNGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A+P       ++ + DA            +     LA   GI L  +  ++H+ + 
Sbjct: 66  VDGFARPSVRKLAPSVLRVDAAHGFAYPALDLAVAEIAPLARSQGIALATIHRSHHFGQA 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMF 178
           G+   + A++G +G+   N+   M  WG ++  IGTNP+ +A   P  P  ++DM++S  
Sbjct: 126 GAVVERLADRGLVGLLLGNAPKAMAFWGGRQPMIGTNPVAIAAPVPEGPPLVIDMALSQV 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +   +  G  +P     D +GN T +     K   +LP+G  KG+ +++++++++ 
Sbjct: 186 ARGKVMAAQQVGEPIPEGWALDPDGNPTTDAAAALK-GSMLPIGGAKGAALALMVEVLSA 244

Query: 239 LLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L+      E +    D      + Q  +AI+           +++  ++          
Sbjct: 245 ALTSSHFGWEASSLLDDVGPPPDLGQTLVAIDPAP-SSEGGFLSRMGDLIAAFAREP--- 300

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +R PG       A   R GIT+  ++ A+I +L
Sbjct: 301 ---GVRPPGSRRLENRARAAREGITLPPTLHAEILSL 334


>UniRef50_B0C6P9 Malate dehydrogenase, putative n=1 Tax=Acaryochloris marina
           MBIC11017 RepID=B0C6P9_ACAM1
          Length = 355

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 81/334 (24%), Positives = 143/334 (42%), Gaps = 7/334 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++V+  QL+A    VL +  + SE A A  +   +    G+ SHG+ +   + + L +G 
Sbjct: 5   IQVSAAQLRAFLTAVLANYPLQSEAATAITDHLVQANLWGMDSHGLQQIMGYDKSLRSGR 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P  +    T    + + +A R+ G    +  M +AI  A + G+ +V + N+NH+   
Sbjct: 65  INPQPKLHIQTDRPTMIRIEADRAPGQYAGQIAMQQAITKAQEMGMAVVGVTNSNHFGMA 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAV-MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           G Y   AA  G IG   +++  V + P+G KE R+G NP    IP+     ++DM+    
Sbjct: 125 GYYTRMAAAAGMIGFATSDTNVVDLAPYGGKEARLGNNPFSWGIPNGDMPIVLDMAAGTV 184

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           S G ++     G  +P + G    G  T E   +  N+   P    KG+GM++V D++  
Sbjct: 185 SGGKIKHFGYQGLPIPPEWGLTAAGETTSEAQAVAVNQAASP----KGAGMALVADLLCG 240

Query: 239 LLSD-GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
            L    A++ +    +    G    F  +++    D      ++   +  +    R D  
Sbjct: 241 PLLGTAAALFKTKSRHDRMNGTGHFFWVMDLAVWSDPEEFAERVGDAIATLKQTPRLDPQ 300

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           Q I  PG             GI V  ++   +  
Sbjct: 301 QPIYFPGELEVVTEQTRIHQGIPVPYALIQDLAR 334


>UniRef50_B5JGV2 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Verrucomicrobiae
           bacterium DG1235 RepID=B5JGV2_9BACT
          Length = 351

 Score =  292 bits (749), Expect = 9e-78,   Method: Composition-based stats.
 Identities = 72/340 (21%), Positives = 139/340 (40%), Gaps = 14/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   E L +   + L   G+  + A   A++       G  +HG+   P ++  LE+G +
Sbjct: 9   RFMAENLLSFAVKALTRAGLAEDRARVVADVLLDADLMGHSTHGLGLLPLYVGALEDGKM 68

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  +   G+   WD +   G     + ++  +E   +H +  V ++ ++H     
Sbjct: 69  EVAGEPVVLNDRGSTLAWDGRYLPGAWLTCRAIEEGLERLGEHPVVTVTIQKSHHIGSLA 128

Query: 122 SYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           SY  +A +KG + +   +     ++ P+G  +     NP+   IP S    + D SMS  
Sbjct: 129 SYPMRAIKKGAMMLLTCSDPNSELIAPFGGLDAVYSPNPIAAGIPTSGRPVIFDTSMSTT 188

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMG----YWKGSGMSIV 232
           ++G+    +  G +LP     D+EG  T +P V+  E +  ILP+G     +KG  + ++
Sbjct: 189 AWGVANRAKQQGERLPGKWMQDNEGKATDDPKVLDSEPSGTILPIGGADHGYKGFALGLL 248

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   LS      E+       +G S     I+ D          ++  +      + 
Sbjct: 249 VEALTCGLSGSGRADEL-----GRWGCSTFIQLIDPDAFGGSDAFRREMDYLAKRCHDSR 303

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 A+RLPG     L  E    G+ + + V   +  L
Sbjct: 304 TRPGADAVRLPGERALALREEQVVAGLVLPEVVKEGLLKL 343


>UniRef50_Q8T901 AT13460p n=10 Tax=Drosophila RepID=Q8T901_DROME
          Length = 461

 Score =  290 bits (744), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 77/340 (22%), Positives = 142/340 (41%), Gaps = 12/340 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V   + +   ++V  +  V  + A   A+        G  S G++R P     L N  + 
Sbjct: 96  VDVLEAQRFVSQVFSAMQVPKQAASEMADALIAADYMGQRSMGIHRLPSIAADLLNCTVA 155

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA P  ++   AI   D   + G + A   MD A++ A + GIG V+ R++N       
Sbjct: 156 GDATPGIVSEKKAIALVDGHNAPGPVVANFCMDLALQKAREVGIGWVSARSSNCIGFASW 215

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFSYG 181
           Y  QA E+  IG+C TN+   + P G  E  +G NP+  A        + D  M+  S  
Sbjct: 216 YACQALEQRMIGLCMTNAAPTLVPAGGIEPVLGENPIACAASGVHEQFVADFGMAACSVD 275

Query: 182 MLEVNRLAG--RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG-YWKGSGMSIVLDMIAT 238
            LE++   G  +Q+P     D  GN T       + +RI       KG G++  +D++  
Sbjct: 276 ELELSYCNGWSKQVPKLVALDRNGNETTSTEEALRAQRIRAFQPEHKGFGLAAAVDILCG 335

Query: 239 LLSDGASVAE-----VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           +++      +     V    +    + Q+++AI+  +    PT + +L      +  A  
Sbjct: 336 VMTGARYANQIQRRGVYSTENAPANLGQVYVAIDPMRF--CPTFEDRLADFHRLLRQAVP 393

Query: 294 ADENQAIRLPGHEFTT-LLAENRRNGITVDDSVWAKIQAL 332
           +   +   +PG +    +   + + G+T+     + ++ L
Sbjct: 394 SKVGKPPMVPGDKELQHMKMVDEQGGLTMSSCTLSVLEEL 433


>UniRef50_Q133C9 Malate/L-lactate dehydrogenase n=7 Tax=Rhizobiales
           RepID=Q133C9_RHOPS
          Length = 366

 Score =  290 bits (742), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 77/348 (22%), Positives = 136/348 (39%), Gaps = 22/348 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V  ++L     +V    G     A            +G  SHGV R P +I+    G 
Sbjct: 7   VTVQADRLIDFVAQVFERAGSSKAEARRIGSYLTTANLTGHDSHGVIRVPVYIRWRNAGA 66

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + PD        L ++   D +   G     + +   IE     G+  V L+NA H  R 
Sbjct: 67  VHPDQTVDVPVDLPSLAVVDGKFGYGQTVGPQAVRIGIEKCKAQGLSAVGLKNAGHIGRI 126

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMS 176
           G +   AA +G + I +  +    ++ P+G  E R+ T P  V +  P  P  ++D + S
Sbjct: 127 GDWAEMAAAEGLVSIHFVTAAGSILVAPYGGVERRLSTAPYCVGVPRPGAPPVVLDFATS 186

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE-------------KNRRILPMGY 223
           + + G + V    G+ LP     + +G  +++P  +                  I   G 
Sbjct: 187 IVAEGKVLVAARGGKALPQGALINPDGTFSEDPATLYGAFEKDGPINHVNGAGAIRAFGE 246

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
            KGSG++++ +++   LS               +      I ++  ++      DA++ R
Sbjct: 247 HKGSGLALICELLGGALSGNG-----ATGPDRPFANGMFSIYVDPQRIDPAHVFDAEVTR 301

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
            +DY  SA+       + +PG       A+   NG+ + D  WA I A
Sbjct: 302 YVDYFKSAKTVAGVDQVLIPGDPELKTRADRTENGVPLSDDTWAAIVA 349


>UniRef50_A8I2I9 Malate/L-lactate dehydrogenase n=5 Tax=Alphaproteobacteria
           RepID=A8I2I9_AZOC5
          Length = 350

 Score =  289 bits (739), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 92/333 (27%), Positives = 156/333 (46%), Gaps = 8/333 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  E L A    +L + G     A   A++     + GV SHGV R PR+++ +  G I 
Sbjct: 8   LAPEALSAFAAGLLEAGGFRPADAKKSADLLVWANQRGVDSHGVLRIPRYVEMVGLGLIN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P A+PK +   GA+   DA  + G    +++ D+AIE+A   G G    RN  H    G 
Sbjct: 68  PAAEPKVVNEWGAVALIDAGLAPGASAMEQVTDKAIEIAGRLGGGFCVGRNVTHAGAVGY 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFS 179
           +  + A +G +GI  T S  +M   GA+   + +NPL +A P   +    ++DMS +  +
Sbjct: 128 FAHRIAARGLVGIVMTASKPLMAYPGARGEVVSSNPLAIAAPSEVAGEPIVLDMSTAAVA 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R AGR +P   G D  G  T +P  +   + + PM   KG+G+S++++++ +L
Sbjct: 188 LGQVLAARDAGRTIPEGWGIDAAGRPTTDPAAV---QALTPMAGAKGAGLSLMIEVLCSL 244

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           L+    +A      +   G +    AI+             ++ +   +     A+  QA
Sbjct: 245 LAGNPLIAPALS-GAAPAGFNGFVAAIDPGAFGSRERFLGDVRGLAAAIHGLPPAEGTQA 303

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           + LPG       AE RR+GI +     +K++ L
Sbjct: 304 VLLPGERGRRT-AETRRSGIPLARGTSSKLKEL 335


>UniRef50_D0LLD6 Malate/L-lactate dehydrogenase n=1 Tax=Haliangium ochraceum DSM
           14365 RepID=D0LLD6_HALO1
          Length = 355

 Score =  288 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 82/336 (24%), Positives = 157/336 (46%), Gaps = 10/336 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  ++ +    +VL+  G+    A + A     T+  GV +HG+   P ++++LE G   
Sbjct: 8   IDSQKAELFVTQVLVRNGLSESDARSVANGLVETSLRGVDTHGLRLLPLYVKELEGGRSN 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
              Q +   +  ++ + DA  ++G +      D+A+E+A   G+G+V++ N+NH+     
Sbjct: 68  ARPQFRFEATRASVVKMDADAALGIMAGFAGADKAVEVARKSGVGVVSVANSNHFGAAAL 127

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           YG + A +G+IGI  T++ A + P+G +    GT+P+    P        +DM+ S  SY
Sbjct: 128 YGLRIARQGFIGIALTHAAARVAPFGGRTQLFGTDPICFTAPRKDGHPFCLDMATSQISY 187

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             ++ +RL G  L      DD G  T EP  +     + P+G +KG G+S+++ ++  LL
Sbjct: 188 SKVKHHRLRGETLEPGWAVDDHGEPTVEPDSV---SALSPVGGYKGQGLSMMVQVLCALL 244

Query: 241 SDGASVAEVTQDNSD----EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           +D     E++  +S        IS  F+AI+     +     +++  ++D V  +     
Sbjct: 245 ADMPLDWELSHLDSGGFSEPRKISHFFMAIDFSAFTNVERFLSQMGILVDTVRDSAARAG 304

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                  G        E  R GI +  + +  + A+
Sbjct: 305 GAVAVA-GDIEERRKEERLRTGIPLSAAEFDSLLAV 339


>UniRef50_B4NGA8 GK22789 n=1 Tax=Drosophila willistoni RepID=B4NGA8_DROWI
          Length = 502

 Score =  287 bits (735), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 74/339 (21%), Positives = 139/339 (41%), Gaps = 15/339 (4%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           + +   + +  +  V  + A   A+        G  S G++R P     L N  +   A+
Sbjct: 148 EAQRFVSDIFAALDVPQDAASDMADALVAADYMGHRSMGIHRLPAIAADLLNCTVSAIAK 207

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P+      A+   +   + G + A   MD AI+ A   GIG V  R +N       Y  Q
Sbjct: 208 PEIQKENDALALVNGSNAPGPVVATFCMDLAIQKAQQVGIGWVVARKSNCIGMASWYACQ 267

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPL-IVAIPSTPITMVDMSMSMFSYGMLEV 185
           A EK  IG+C +N+   + P G  E  +G NP+  VA       +VD   S  S   LE+
Sbjct: 268 AMEKRLIGLCMSNAAPTLVPSGGIEPILGENPIACVAAGEHEQFLVDFGQSSCSVDQLEL 327

Query: 186 NRLAG--RQLPVDGGFDDEG-NLTKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIATLLS 241
           +   G  ++LP     ++ G   T +     + +R  P    +KG G++ ++D++  ++S
Sbjct: 328 SYCNGKLKELPPALALNESGEQDTNDVAEALRAQRFYPFRPAYKGFGLAAMVDILCGVMS 387

Query: 242 DGASVAEVTQDN-----SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
                 ++ +       +  Y + Q+++AI+  +     T + +L      + +A     
Sbjct: 388 GAQYANQLRKRGIFSTENKPYDLGQLYVAIDPRQF--CTTFEDRLADFQHLLRNAMPCPV 445

Query: 297 N--QAIRLPGHEF-TTLLAENRRNGITVDDSVWAKIQAL 332
              + I  PG +    +   ++  G+ +       +Q L
Sbjct: 446 GCKEQIMAPGDKELLHMQMVDKEGGLRISPCTLGILQEL 484


>UniRef50_A8TSK9 Malate dehydrogenase (NADP+) n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TSK9_9PROT
          Length = 338

 Score =  286 bits (733), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 73/340 (21%), Positives = 147/340 (43%), Gaps = 18/340 (5%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +   L     RV ++  VD +TA   AE   R    G+ SHG+ R P + +Q  NG +
Sbjct: 3   QYSPADLTDLIIRVFVNSKVDPQTARVVAEALVRAEADGISSHGIARVPPYAEQAMNGKV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+P    +  A+   D++        +  ++RA E+  + GI  + +++++H+   G
Sbjct: 63  DGFAKPTVTRTAAAVLDVDSRIGFAFPAIRLGLERAAEIVKETGIVAIGIKHSHHFGVAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMF 178
            +   AA +G + + ++N+ A + PWG  +   GTNP+  A P     P  ++D+S+S  
Sbjct: 123 HHVEDAANRGLMALAFSNTPAAIAPWGGSKALYGTNPIAFACPRGDGRPPLVIDLSVSTV 182

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG----YWKGSGMSIVLD 234
           + G + +    G  +P D   D  G+ T +  V      + P+G      KG+ + ++++
Sbjct: 183 ARGKVVLADKTGEAIPDDWALDANGHATTDAKVAL-TGSMAPLGGRTAGAKGAALGLMIE 241

Query: 235 MIATLLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           ++   L+      +     +       I  + + I+ +    G    A+ + +   + + 
Sbjct: 242 LLCGALTGSNFGYQGSSFFEPTGVPPSIGHLILVIDSNAFGGGAGTVARAEEMFAEILNQ 301

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                    RLPG             GI + D++   ++A
Sbjct: 302 P------GTRLPGDSRLAKR-SAAPGGIAIPDALAQDLEA 334


>UniRef50_C1F8E3 Malate/L-lactate dehydrogenase family n=1 Tax=Acidobacterium
           capsulatum ATCC 51196 RepID=C1F8E3_ACIC5
          Length = 334

 Score =  286 bits (733), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 147/333 (44%), Positives = 205/333 (61%), Gaps = 1/333 (0%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++ F+ L  AF   L   G   E A+ CA +FA TT  GVYSHG NRFPRF+  + NG 
Sbjct: 2   LRIPFDDLHRAFIAALTHVGFTPERAELCARLFAETTLDGVYSHGANRFPRFLAMIRNGA 61

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+ +++ GA+E+WD +R  GNL A   M+RA+ L+  HGIG +ALRN NHWMRG
Sbjct: 62  VDVHATPQCMSAFGALERWDGRRGPGNLNAHAAMERALALSRTHGIGCLALRNTNHWMRG 121

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFS 179
           GSYGWQAA  G I +CWTN++  +P WG +E  +G NPLIVA+P      ++DM+MS FS
Sbjct: 122 GSYGWQAANAGSIALCWTNTMPNLPAWGTREASVGNNPLIVAVPRRAGHLVLDMAMSQFS 181

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           YG LE        LP+ GGFD  G LT +P  IE ++R LP+GYWKGSG++++LD +A +
Sbjct: 182 YGALESYSRRSELLPIPGGFDASGTLTNDPAAIEASQRPLPIGYWKGSGLALLLDAVAAM 241

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
            + G +  ++ +D   E G+SQ+FIAI    L      +     I+  + +A   D  + 
Sbjct: 242 TALGNATHQLARDPLQETGLSQMFIAIHPAALDAAADANHLADEIVASLHAAAPVDPGRP 301

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            R PG +   L  EN R GI V+D +W +I A+
Sbjct: 302 ARYPGEQTLRLREENLRLGIPVEDVIWQQILAV 334


>UniRef50_A0Z6D1 Malate/L-lactate dehydrogenase family protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z6D1_9GAMM
          Length = 333

 Score =  285 bits (731), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 76/335 (22%), Positives = 143/335 (42%), Gaps = 14/335 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++ + +++     L++ G   E A   A   A     G+ + G+     +++ L+ G + 
Sbjct: 4   LSLQAIESLCRESLLAVGASDEQAAIVAAEIAEAEAEGIRNVGLGYIHLYLKHLKVGKVK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P+AQP  + +  A    DA     +        R IE A + G+ ++A+  ++     G 
Sbjct: 64  PNAQPSVVKTSAASTVVDADFGFCHHAYMVGEQRLIETAREQGVAMLAIHQSSSAGVLGW 123

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           +  + A++G + + + NS   +   G K    GTNP     P  +    +VDM+ +  + 
Sbjct: 124 FVRRLAQQGLVSLMFANSSKAVAAHGGKVPFFGTNPFAFGAPRGTDEPLVVDMATASTAR 183

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             L      GR++      D +GN T +P    K    LPMG  KG G+ +++D++A +L
Sbjct: 184 VNLVKAAAEGREIEPGHAIDADGNPTTDPSAGLK-GAQLPMGGPKGFGLGLMVDVLAGVL 242

Query: 241 SDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      E       +     + Q  IAI+ + L         L+ +   +T      EN
Sbjct: 243 TGSNCSYEASMFANIDGGPPNVGQTIIAIDPNFLDG--NFTTHLETMFAALT------EN 294

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +R+PG     L  ++  +G+ V  S+  +I  L
Sbjct: 295 NDVRIPGERRAQLRVKHEADGVDVPQSLIDQITEL 329


>UniRef50_C3MH43 Putative uncharacterized protein n=1 Tax=Rhizobium sp. NGR234
           RepID=C3MH43_RHISN
          Length = 351

 Score =  285 bits (731), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 86/332 (25%), Positives = 151/332 (45%), Gaps = 7/332 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +  + L+A    +L + G  ++ A   AE+       G  SHGV R PR+I+  E G + 
Sbjct: 10  IAKDILEAFSAALLEAGGFRADYARQSAELLVWANLRGADSHGVLRIPRYIEMAELGIVK 69

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            DA+P+     GA+   D  R  G        DRA+ELAA  GIGL ++   +H    G 
Sbjct: 70  GDAKPELAREFGAVAVIDGDRVPGATGMAMAADRAVELAAKFGIGLCSILRTSHAGAVGF 129

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSMFS 179
           +  + A  G +G+  T S  +M   G+K   + TNP+ +A PS       ++DMS +  +
Sbjct: 130 FTERVARAGMVGVAMTASKPLMIYHGSKAEGVSTNPISIAAPSRNAARPIVLDMSTAAVA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   + AG+ +P D G D  G  T +P ++   + +LPM   KGSG+S++++++ ++
Sbjct: 190 LGKIMAAKDAGKSIPPDWGVDANGVATTDPAIV---KAVLPMAGPKGSGLSLMIEILVSV 246

Query: 240 LSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQA 299
           L     ++    D  D      + +A+           + ++ R+   +     A     
Sbjct: 247 LGGNPLISAALTDKRDAGFNG-LVLALSPTAFGPRDQLEGEIDRLSHAIKGLPPALATDD 305

Query: 300 IRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           + LPG     L  +  + GI +      ++  
Sbjct: 306 VLLPGERGFLLAEKRLQEGIPLALGTIGRLAE 337


>UniRef50_B9QUQ5 Malate/L-lactate dehydrogenase subfamily n=1 Tax=Labrenzia
           alexandrii DFL-11 RepID=B9QUQ5_9RHOB
          Length = 349

 Score =  285 bits (730), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 71/336 (21%), Positives = 144/336 (42%), Gaps = 15/336 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +++    +       ++ GV    A + A         G   HG +R   +  Q+++G I
Sbjct: 19  RLSLCNAELLIKSAFLAVGVPDLAAQSVANALVAAEAEGQVGHGFSRVEDYAAQVQSGKI 78

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+        +    DA           ++++  E+A +HG   + +  ++H     
Sbjct: 79  AAAAEVIISHKGISSLLADAGFGFAYPALDAVIEKGSEVALEHGCATMGITRSHHCGALS 138

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
               + A++G + I   N+ A M P+GAK+   GTNP+  A   P     +VD+S+S  +
Sbjct: 139 VQVEKLAKQGLMAIMVANAPAAMAPFGAKDPVFGTNPIAFAAPRPGKDPLVVDLSLSRVA 198

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   R AG+ +P     D +GN T       +   +LP+G  KG+ ++++++++A++
Sbjct: 199 RGKVMNARKAGKDIPEGWALDKDGNPTTSAEAALE-GTMLPIGEAKGTALALMVEILASV 257

Query: 240 LSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++  +   E       +    G+ Q  IA++    +D     A++  ++  + +      
Sbjct: 258 MTGASKSTEASSFFSADGPPPGVGQFLIAMKP---MDTEHFAARIDTLLSLIETM----- 309

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            +  RLPG      +A+ R  GI V       ++ L
Sbjct: 310 -EGARLPGSRRAATIAKARVEGIDVPVRYVDAVRKL 344


>UniRef50_UPI0001C320A5 Malate/L-lactate dehydrogenase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C320A5
          Length = 360

 Score =  285 bits (730), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 88/334 (26%), Positives = 152/334 (45%), Gaps = 7/334 (2%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           +   L      V    G+ +  A   A         G+ SHG    P +++++  G +  
Sbjct: 8   SPSWLVERLAAVFSGAGLPAAAARTVATALVDADMRGIPSHGSLLVPMYVERIVKGSVAT 67

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
             +P  +  LGA+   DA  ++G ++A   M  AIE A  HG+G VA+R+A H+     Y
Sbjct: 68  ATEPATVADLGAVAVLDAGHALGVISADTAMALAIEKARAHGLGAVAVRHAFHFGGAFRY 127

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYG 181
              AA+ G +G+   N+  +MP  G     +G NPL V +P       ++DM++S  + G
Sbjct: 128 VQAAADAGMVGVAAANTRPLMPAPGGAHAVVGNNPLAVGVPRAGGEPLVLDMALSEAALG 187

Query: 182 MLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLS 241
            + +    GR +P     D +G  T +P        +LP    KG G+++++D++  +LS
Sbjct: 188 KIRLAAQEGRAIPATWATDADGAPTTDPVAAI-AGLLLPAAGHKGYGLALIVDVLTGVLS 246

Query: 242 DGASVAEV---TQDNSDEYGISQIFIAIEVDKL-IDGPTRDAKLQRIMDYVTSAERADEN 297
            GA    V     D       +  F+A++V +   D  T  A++  +   VTS   A   
Sbjct: 247 GGAFGRSVNGLYADTGVPNDCAHFFLALDVARFAGDLDTFSARVAELSAQVTSPPTAPGV 306

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           + + +PG       A  R  G+ +D +V A+++ 
Sbjct: 307 ERLLVPGQLEAERHAAAREQGVALDATVLARLRE 340


>UniRef50_B9JPX6 Malate/L-lactate dehydrogenase n=1 Tax=Agrobacterium radiobacter
           K84 RepID=B9JPX6_AGRRK
          Length = 340

 Score =  285 bits (729), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 80/338 (23%), Positives = 145/338 (42%), Gaps = 15/338 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +E +      +L   G  + +A   A   A   + G  SHG+ R   ++  +++G +
Sbjct: 3   RQPYETVVETLELILTKHGYSARSAGILALNCATAQQDGSESHGLFRIKDYLAIIKSGYV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D  PK +       + DA      +      +R ++ AA++GI +VA+RN++H     
Sbjct: 63  NGDPNPKVVDVAPGFIRVDADNGFAQIALADAKERLVQKAAENGIAIVAIRNSHHLGALY 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFS 179
                 A++G++ +   NSIAV+ P G +    GTNP+  A P    P  + D + S  S
Sbjct: 123 LDVEDLADRGFVSLAVVNSIAVVAPPGGRAGVYGTNPMAFAAPRAEGPPLVFDQASSTMS 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +G ++V    GR LP   G D  G  T  P  I     +   G  KG+ ++++++++   
Sbjct: 183 HGDVQVAAREGRLLPEASGIDKRGIPTNSPHAILNGGALSTFGGHKGASIALMVEILCAA 242

Query: 240 LSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLIDG-PTRDAKLQRIMDYVTSAERAD 295
           L       EV       +      +  I I+     DG P    ++  +++ ++ A    
Sbjct: 243 LVGADFSYEVDWSETPGARSARTGETIILIDPRTGADGLPPLAERVGTLIEALSVA---- 298

Query: 296 ENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
                R+PG     + A +  NG + VD+  W  +  L
Sbjct: 299 --GQKRIPGDRR--IKARSEANGSVPVDEKQWLALLEL 332


>UniRef50_B3R983 Malate/L-sulfolactate dehydrogenase n=3 Tax=Burkholderiales
           RepID=B3R983_CUPTR
          Length = 340

 Score =  284 bits (728), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 80/336 (23%), Positives = 148/336 (44%), Gaps = 12/336 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++  ++L+      L   G  +  A A A    R   +G+ SHGV+R P ++  L +  +
Sbjct: 3   RIALQELERVAVAGLRRAGASALQARATALALVRADAAGLPSHGVSRVPMYVAHLRHDRV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A+P   ++  +    DA+           +  A+  A   G G+ A+ N++H+    
Sbjct: 63  DGHAEPAVQSTRASAVLVDARCGFAFAACDLAIAEAMARARATGAGVAAVTNSHHFGAAA 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
                 A  G +GI   NS A MP WG K    GTNP+      P     ++D+S+S  +
Sbjct: 123 LPLEAVARAGMVGIAMGNSPAAMPAWGGKRPLFGTNPIAAVFPRPGHAPVVIDLSLSEVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + V    G+ +P     D+ G  T +     +   +LP G  KG+ ++++++++ T 
Sbjct: 183 RGKIMVAARQGKPIPHGWALDEAGQPTTDAQAALR-GSMLPAGGVKGAMLALLVELLVTS 241

Query: 240 LSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+     AE      D  +   I Q+F  ++           A+++ ++  +        
Sbjct: 242 LAGARFGAEADSFFTDAGNRPRIGQLFFVLDPGAFAGSQVYAARVEALLAAMLD------ 295

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           ++  R+PG    T  A+   +GI V D++W ++QAL
Sbjct: 296 DEGTRVPGARRDTAQAQAAAHGIEVPDALWRELQAL 331


>UniRef50_C5CKI2 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKI2_VARPS
          Length = 350

 Score =  283 bits (726), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 83/336 (24%), Positives = 152/336 (45%), Gaps = 7/336 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+   L+     +  S+G+ +  A + A+        GV SHGV   P +++++  G 
Sbjct: 4   VSVSVHALRGLTAALFRSQGLTALRAASVADSLVCADLEGVASHGVALVPLYLERISKGS 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P A+P  +   G +    AQ ++G ++A   ++ A   A +HG+ +V++R+A H+   
Sbjct: 64  VDPHAEPLVVEDHGGLVVMSAQNALGQVSAAVAVELAAARAREHGVSVVSVRHAFHFGTA 123

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSMSMF 178
             +  Q A  G +G  ++N+  +MP  G  E  +G NP+ +AIP+      +VDM+MS  
Sbjct: 124 SYWARQFAAAGMVGFAFSNTRPLMPAPGGAERVVGNNPMAIAIPARVDEPLVVDMAMSAT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +    G  +P     D  G  T       +   +LP    KG G+++ +D++  
Sbjct: 184 AMGKIRLAEANGEAIPTGWATDAAGRATTSATEAIQ-GMLLPAAGPKGFGLAVAIDLLCG 242

Query: 239 LLSDGASVA---EVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            LSDGA  A    +  +    Y  S  FIAI+  +L  G     ++      +  + RA 
Sbjct: 243 ALSDGAVGAAVRPLYGELDKPYDCSHAFIAIDAARLHGGAGIAPQVAGFAQAIRDSRRAP 302

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             + I  PG       A N  +   +   +  ++  
Sbjct: 303 GTERIYAPGDLERARRAGNGEH-CPIAGELAQRLNQ 337


>UniRef50_A1BBM1 Malate/L-lactate dehydrogenase n=1 Tax=Paracoccus denitrificans
           PD1222 RepID=A1BBM1_PARDP
          Length = 356

 Score =  283 bits (726), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 79/337 (23%), Positives = 140/337 (41%), Gaps = 14/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  +++ A    VL + G+  + A+A A++  R       SHG+ R   ++  L  G 
Sbjct: 23  VTMRLDEIFALVLSVLTANGLSRDQAEAIADIVTRAEADACRSHGLYRVEGYVAGLRAGR 82

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P AQP+      A+ Q D  +      A       I  A ++GI  +A+   +H+   
Sbjct: 83  VNPTAQPRVRRLRPALLQVDGDKGFAPFAANLARPHLIAAARENGIAAMAIARTHHFSAL 142

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
            +      E G +  C+      + P G     +GTNP+    P       + D + S  
Sbjct: 143 WADLEPLVEAGLVAWCFVVGQCSVAPHGGSTPLMGTNPIGFGWPRPDGAPFIFDFATSAA 202

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +E+ RLAG  +P   G D EG LT +P        +LP G  KGS +S+++++IA 
Sbjct: 203 ARGDVELKRLAGEPIPAGWGIDAEGRLTLDPAEALS-GALLPFGGHKGSALSMMVELIAG 261

Query: 239 LLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L    +  +V      +       ++FIA++   L       A  +R      +     
Sbjct: 262 PLIGELTSKQVAALGHRDDGPPPGGELFIALDPASLGGSAP--AVAERFFLDAKAQP--- 316

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               +RLP        + +  +G+ V   +  +I+AL
Sbjct: 317 ---GLRLPSERRYVARSRSHASGVGVPSDLLRRIKAL 350


>UniRef50_Q11B93 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11B93_MESSB
          Length = 354

 Score =  283 bits (726), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 69/336 (20%), Positives = 130/336 (38%), Gaps = 14/336 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
                LK     +L +  V ++ A+  A++       G  +HG+ + P ++  L  G + 
Sbjct: 7   YDANALKDYARNLLKALDVQTDIAEVVADVLVEGDLLGHSTHGLAQLPSYLDNLAKGQMK 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P      ++   A   WD Q   G    +     A   A   G G V +R ++H     +
Sbjct: 67  PSGTYSVVSDFPAATTWDGQWLPGPWLTRTACIEAKTRARKFGTGTVVIRRSHHIACLAA 126

Query: 123 YGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFS 179
           Y      +G++ I  ++  AV  + P G     +  NP+ V IP+     ++D+SMS+ +
Sbjct: 127 YLEPLTAEGFVCIIQSSDPAVKAVAPHGGTRPFLTPNPVAVGIPTKGDPILIDVSMSIAT 186

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGV--IEKNRRILPMG----YWKGSGMSIVL 233
            GM      +G + P     D +G+ T +P V   +    ++ +G      KG G+++++
Sbjct: 187 VGMARRLIASGERAPFPWLLDGDGHPTDDPNVIDADPKGSLMLLGGIEAGHKGFGLALMV 246

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           + +   L           D    +G S     ++ D          ++  I D   S   
Sbjct: 247 EALTGGLGGHG-----RADKPTNWGASVFVQVLDPDAFGGKEALLREMSFIADECVSGPS 301

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            D N  +R+PG        E    G+ +   +   +
Sbjct: 302 RDINNPVRMPGSAGLRRKREALERGVPLHSIIMESL 337


>UniRef50_A1WRH9 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1WRH9_VEREI
          Length = 354

 Score =  283 bits (726), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 66/339 (19%), Positives = 139/339 (41%), Gaps = 14/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + +  +L+    ++L   G+    ADA A         G  +HG+     +++++  G +
Sbjct: 6   RFSAAELRQFSTQLLQKAGLPLAPADAVARTLVDGDLLGHDTHGLALLVPYVREVSKGAM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  ++   A   W+ +R  G     K +D  I  A + G   + + +++H     
Sbjct: 66  TTSGEPDVVSDRPAALVWNGRRLPGPWLVHKGIDALIARARELGTAALVIHHSHHIACLA 125

Query: 122 SYGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +Y  +A E+G++ +  ++  AV  + P+G        NP+   IP++    +VD+S S+ 
Sbjct: 126 AYLLRATEEGFLMVLSSSDPAVQSVAPFGGTRAVFTPNPIAAGIPTSGTPLLVDISASIT 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           + GM      AGRQ   +   D +GN +++P     +    ILP+G      KG G++++
Sbjct: 186 TNGMSNRLHKAGRQFEEEWMLDAQGNPSRDPAVLAADPPGSILPLGGLSAGHKGFGLAVL 245

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   LS          D    +G +      +            ++  I +   S  
Sbjct: 246 IEALTGGLSGFG-----RADPPTGWGATVFMSLYDPAAFGGQAAFRRQMDHIAEACRSNP 300

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                  +R+PG       A+    G+ +  ++   ++ 
Sbjct: 301 PRPGVGQVRMPGDRGMARRAQQLEQGVALHPTIAPMLRE 339


>UniRef50_C6B638 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium leguminosarum
           RepID=C6B638_RHILS
          Length = 353

 Score =  283 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 72/336 (21%), Positives = 136/336 (40%), Gaps = 13/336 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +    L     ++L   G++++ A+  A +       G  +HGV+    +++ LE+G + 
Sbjct: 6   IDRIALTQFAKQILTRAGMEADKAETTAAVLVEGDMIGHETHGVSLLSWYVEALEDGSLA 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                + +   GA   WD +   G     K +++A E   DHG+   A+RN +H     +
Sbjct: 66  KSGSYEIVNDRGAAFVWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSA 125

Query: 123 YGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFS 179
           +  Q  E+G I     +  A   + P+G  +  +  NP+    P S    ++D+S S+ +
Sbjct: 126 FMRQVTERGLIVQLSVSHPAASRVAPYGGTKPLLTPNPMAAGFPTSADPILIDVSASITT 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI-EKNRRILPMG----YWKGSGMSIVLD 234
             M +    AG++ P    F   G  T +P  + E+   ++P+G      KG G+ ++++
Sbjct: 186 TTMTQNLAKAGKKFPEAWAFTVAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGLGLIVE 245

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           ++   LS            S  +  S     I+           A+   +     S   A
Sbjct: 246 LLGQGLSGKGRAN----TPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPPA 301

Query: 295 D-ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
              N  +R+PG             G+ V D+ W K+
Sbjct: 302 PWNNGPVRMPGDSAAQKRRSALEEGVPVGDAAWQKL 337


>UniRef50_Q11CF6 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11CF6_MESSB
          Length = 358

 Score =  283 bits (724), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 66/339 (19%), Positives = 137/339 (40%), Gaps = 14/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   E L+A    +    G+ +E A   A +       G  +HG+   P +++ +E G +
Sbjct: 11  RYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGM 70

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D  P+ +  LGA   WD ++  G    ++    A+  A   G+G VA++ ++H    G
Sbjct: 71  TLDGDPEVLNDLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLG 130

Query: 122 SYGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +Y   A   G + +        + + P+G     + +NP+    PS     ++DMS ++ 
Sbjct: 131 AYLEPAVAAGCMVLVTLTDPGHSSVAPFGGVTPVLTSNPIAFGAPSPDRPILIDMSTALM 190

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           + G +   R  G  LP     D +G  + +P     +    ILP+G      KG  + ++
Sbjct: 191 TNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEAGHKGFSIGLI 250

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++++   LS          +  D +  +   + ++            ++  ++D    + 
Sbjct: 251 VELLTGCLSGRG-----RAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDLCHGSA 305

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                  + LPG +  +     RR+G+ +   + A +  
Sbjct: 306 LRPGFNHVDLPGAQAFSRREGQRRDGVLLSPGIVAGLAE 344


>UniRef50_B8DQ74 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=B8DQ74_DESVM
          Length = 356

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 76/351 (21%), Positives = 133/351 (37%), Gaps = 29/351 (8%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  + L A    VL   GV    A + A         G+ SHGV R P++  Q+  G 
Sbjct: 3   VILRPDDLAALCRTVLERAGVLPAAASSVAGALVAAECMGIPSHGVARLPQYADQVAAGK 62

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +  DA P+  T L A  + DA         +  +D A+ LA   G   + + N++H    
Sbjct: 63  VRGDAVPRVETPLPATVRVDAGCGFAYPALEAGLDVAVPLALRMGCAALGVTNSHHCGVA 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI----------------- 163
           G +  +AA +G + + + N+ A M PWG     +GTNPL  A                  
Sbjct: 123 GLHVERAARQGLVALLFANTPAAMAPWGGNRASLGTNPLAFACPAPPEDAPEPTAAAGAG 182

Query: 164 PSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY 223
           P     ++D+S+S  + G +      G+ +P     D  G+ T +         +LP G 
Sbjct: 183 PEHDPLVMDLSLSTVARGKIVAAAREGQPIPAGWAVDAHGSPTTDARAAL-GGMLLPFGG 241

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
            KG+ ++++++++A  L+      E +             Q  + I             +
Sbjct: 242 AKGAALALMVELLAASLTGSNHAYEASSFLDAAGGPPRTGQCMLLIAPQAFG--ADFSGR 299

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              ++ +V            RLPG           R G+ +  S+   +  
Sbjct: 300 AAALLGHVLDQPCT------RLPGARRFERQRRAHREGVAIPWSLHQDMLR 344


>UniRef50_Q125C6 Malate/L-lactate dehydrogenase n=1 Tax=Polaromonas sp. JS666
           RepID=Q125C6_POLSJ
          Length = 353

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 76/340 (22%), Positives = 148/340 (43%), Gaps = 15/340 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           + T   L    +++L + G+ +  AD  A +   T     ++HGV   P +I QL+NG +
Sbjct: 6   RHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLM 65

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
             D +P+ +   GA   WD     G     K +  A E  A HG+   A+R ++H     
Sbjct: 66  GTDGEPEVVRDTGATVVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLA 125

Query: 122 SYGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMF 178
           +   QA ++G + I  T+      + P+G ++  +  NP  +  P +    +VD+  S+ 
Sbjct: 126 ALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVLTPNPFAIGYPGSKAPVLVDICASIT 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN---RRILPMG----YWKGSGMSI 231
           +  M      AG Q       D+ G  T +P V+E+      +L +G      KG G+++
Sbjct: 186 TVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKGFGLAL 245

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           +++ +   L+    +     D  + +G +     ++ +          ++  I D   ++
Sbjct: 246 MVEALTQGLAGHGRI-----DAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRAS 300

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
                +  +RLPG + +  +A  ++ GI + D+   K+ A
Sbjct: 301 TPVQPDGLVRLPGDQASGNIARAQQQGIALSDATLDKLAA 340


>UniRef50_Q1GLV8 Malate/L-lactate dehydrogenase n=14 Tax=Proteobacteria
           RepID=Q1GLV8_SILST
          Length = 344

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 77/336 (22%), Positives = 145/336 (43%), Gaps = 14/336 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T  ++++     L++ G     A   A   A T   GV SHG+   P + Q +E G + 
Sbjct: 16  LTLSEIESLAFDALVAAGTSPANARPLAVATAMTEADGVASHGLAYIPIYAQHVECGKVD 75

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A PK      A+   DA     +       ++ I LA + G+ ++A+ N+ +    G 
Sbjct: 76  GQANPKVAHPRPAVITVDAATGFAHRAIDLGFEQLIPLAKEMGVAVLAVNNSYNCGVLGV 135

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI---TMVDMSMSMFS 179
           +  + A+ G +G  +TN+ A + P G  +  +GTNP  ++ P +      ++D S S  +
Sbjct: 136 HTQRLAQAGLMGFGFTNAPASIAPSGGAKPVVGTNPFSISAPGSDGTAALLIDQSASTIA 195

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
              +  +   G+ +P     D +G  T +P    K   ++P G +KG G+++ ++++A  
Sbjct: 196 KSEVMKHAREGKPVPQGWVLDADGQPTIDPDAGLK-GSMVPSGGYKGVGIALTVELLAAA 254

Query: 240 LSD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           ++    GA  +  +          Q FIAI+ D    G     KL  ++           
Sbjct: 255 MTGATLGAVASPFSGTAGGPPKTGQFFIAIDPDA-TSGGLFQEKLADLISAFRD------ 307

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG    +        G+ V+ ++  +++AL
Sbjct: 308 QDGARLPGDGRQSARLRAATEGVRVNAALLERVRAL 343


>UniRef50_C6B553 (R)-2-hydroxyacid dehydrogenase n=6 Tax=Rhizobiales
           RepID=C6B553_RHILS
          Length = 344

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 88/317 (27%), Positives = 145/317 (45%), Gaps = 7/317 (2%)

Query: 19  RGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQ 78
            G   + A   A +       G  SHG+ R PR ++++E G I P  +  +     A+ +
Sbjct: 19  HGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIEAGVIDPQTKGTQRWRADAVLE 78

Query: 79  WDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWT 138
            +    +G + A   ++R      D GIGLVA+RNANH      Y    A  G++GI  +
Sbjct: 79  VEGASGLGPVVAMAAIERLSPHIPDLGIGLVAVRNANHLGMLAHYVEAIAAMGFVGIALS 138

Query: 139 NSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFSYGMLEVNRLAGRQLPVDG 197
           +S A++ P+G     +GTNP+ +A+P +    ++D++ S+   G +  +   GR +P   
Sbjct: 139 SSEALVHPFGGTRAMLGTNPIAIAVPTAEEPLVLDLATSLVPMGSIHHHAATGRPIPEGW 198

Query: 198 GFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQ--DNSD 255
             D  GN T +PG   K   I P G  KG G+ I ++++   L+  A   +     D+  
Sbjct: 199 ARDAAGNPTTDPGRA-KAGAIAPFGDAKGYGLGIAMELLVAALAGSALAPDARGTLDSQS 257

Query: 256 EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENR 315
                 +FI IE       P   A+L   +D V ++  A   + + +PG       A   
Sbjct: 258 PCNKGDVFILIEPSL---APGLPARLSTYLDAVRASPPASAGKPVLVPGDRARRRRAAAS 314

Query: 316 RNGITVDDSVWAKIQAL 332
           RNG  +D  +W  + AL
Sbjct: 315 RNGFEIDQRLWEDLNAL 331


>UniRef50_Q5QTW6 Malate/L-lactate dehydrogenase family enzyme n=2 Tax=Idiomarina
           RepID=Q5QTW6_IDILO
          Length = 356

 Score =  280 bits (718), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 71/339 (20%), Positives = 130/339 (38%), Gaps = 13/339 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++  + +L       L   G   E A   +         G  +HG+ R     Q L +G 
Sbjct: 6   VRFDYSELSDWARTCLTEAGASGEVARNVSYYLLEGDLLGFSTHGLIRLLNNCQWLRDGK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            +   QP  +    A+  WDAQ   G     + +D A ++A   G G V +R + H    
Sbjct: 66  SLAKGQPVVLRERAAVANWDAQFLPGPYVVPQAIDAACKMAKQAGTGTVVVRRSQHVAAL 125

Query: 121 GSYGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSM 177
            +Y   A ++G +     ++     + P+G KE     NP  V +P S    + D+S SM
Sbjct: 126 AAYLSIATDQGLVVSLMCSTPGQRAVAPFGGKEAVFSPNPFAVGVPSSNNPLLFDISFSM 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMG----YWKGSGMSI 231
            + G +   +  G +LP       +G  T +P    +     I P+G     +KG G+++
Sbjct: 186 TAAGKVRQAKANGTRLPYKALIKPDGEWTDDPLTFFESPGSSIAPLGGEQLGYKGYGLTL 245

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             ++ +  LS         Q + D    S     I+ +   +      ++  ++     +
Sbjct: 246 FSEIWSMALSQYG----RRQGSDDGDANSIWVQVIDPEAFGEKQKFLQQVDDLLADSRKS 301

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             A   Q +R+PG        E  + G++   +    +Q
Sbjct: 302 APAVPEQPVRIPGEGAQKRKREQLQQGVSYSSATLKVLQ 340


>UniRef50_Q1GM21 Malate/L-lactate dehydrogenase n=2 Tax=Ruegeria RepID=Q1GM21_SILST
          Length = 348

 Score =  280 bits (717), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 84/339 (24%), Positives = 145/339 (42%), Gaps = 16/339 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++T ++++A   RVL   G  S    A +EM  R       SHG+ R       +++G I
Sbjct: 10  QLTLDEVRALAERVLTHCGYASAHVAAISEMLYRCQLDDCQSHGLFRLFMCANTMKDGKI 69

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
              A P+  +   AI + DA+  +  L  ++ M   IE A  +G+  +A+ N  H+    
Sbjct: 70  DAAASPQIHSEDTAIIRADAREGMSLLAVQEAMPTLIEKARRYGMAALAVNNCFHFSALW 129

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
                 +  G  G+    S + + P G  +  +GTNP+  + P         D + S F+
Sbjct: 130 PEVEALSTAGLAGLSMVPSHSWVAPAGGTKGTLGTNPIAFSWPRKGQDPFTFDFATSGFA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +E+ + AG+ LP     D+ G  T +P     N  +L  G  KGS +SI+++++A  
Sbjct: 190 RGEIELYKRAGKPLPEGVAIDERGQPTCDPDAAL-NGAMLTFGGHKGSALSIMIELMAGP 248

Query: 240 LSDGASVAEVTQDNSDE---YGISQIFIAIEVDKLIDG--PTRDAKLQRIMDYVTSAERA 294
           L D     E               QI +A + +K   G     DA+ +R+   + +    
Sbjct: 249 LIDDLISLESEAAAGRPGCAPYHGQIILAFDPEKFSGGRVAQNDARAERLFADIIA---- 304

Query: 295 DENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQAL 332
              Q  RLP        A N   G + +  +++  ++AL
Sbjct: 305 ---QGARLPSQRRYAARARNLERGYLEIPSALYRDLEAL 340


>UniRef50_UPI00016C5312 putative dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C5312
          Length = 350

 Score =  279 bits (714), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 11/336 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            +   L      +  + GV +  A   A         G  SHGV R P+++  +  G   
Sbjct: 4   FSPAALTQLSQTLFEAVGVPTTDAATVARSLVDANLCGHDSHGVMRVPQYLDFIRKGTYK 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A    ++   A+   DA   +G +   +++D+ +  A   GI    LRN  H  R G 
Sbjct: 64  AGAPLTVLSETPAVVAADAGWGLGQVQTYRLLDKLVPKAKALGIAAGTLRNCGHTGRLGE 123

Query: 123 YGWQAAEKGYIGICWTNSIAV---MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           Y    A++ +      NS      + P G  E RI TNP+ +  P ST   ++D   S  
Sbjct: 124 YAEFVAKENFALFAAVNSHGSGRRVAPPGGTEGRISTNPICMGTPTSTDPVVIDFGTSSV 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGY---WKGSGMSIVL 233
           + G +                D  G  T +P V+       +LP G    +KG G+ ++L
Sbjct: 184 AEGKVRAQFQKKEPAGEGWLIDHTGQPTTDPSVLYNEPRGALLPFGGTQAYKGFGLGLLL 243

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           D++   LS GA             G + +F+               +   +  YV S   
Sbjct: 244 DLLCGGLSGGACSNPTF--PLAGQGNAAVFVLFNPALFGGVEHFLKETDGLTAYVRSCPT 301

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
           A     I LPG    T   +  ++GI V D  W  I
Sbjct: 302 AAGAGTITLPGDPERTAKGKRTKDGIPVPDGTWELI 337


>UniRef50_C1D4D2 Malate/L-lactate dehydrogenase n=1 Tax=Laribacter hongkongensis
           HLHK9 RepID=C1D4D2_LARHH
          Length = 348

 Score =  279 bits (714), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 82/338 (24%), Positives = 140/338 (41%), Gaps = 10/338 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+T ++++      L + G  +  A   A         G  SHG+   P ++  +  G 
Sbjct: 1   MKLTADRMRHMAEATLTALGSTAAEARLVAGHLVEANLRGHDSHGIGMLPFYVDSVARGT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GA+ Q+  +R  G   A + M  AI       + L+ L  A+H  R 
Sbjct: 61  LHPNQPARLLNDQGAVLQFSGERGYGQRVAVEAMRAAIARVRQTQVVLMTLSAAHHLGRI 120

Query: 121 GSYGWQAAEKGYIGICWTN----SIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDM 173
           G YG  AA  G++ I + N       ++ P+G    R GTNPL +A+P     P  ++D 
Sbjct: 121 GHYGELAARLGFVSIHFVNVIDYDQPLVAPFGGTAPRFGTNPLCIALPGGVREPPFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK--NRRILPMGYWKGSGMSI 231
           + SM +YG   V  LAGR+       D  G  T +P  + +     + PM   KGSG+  
Sbjct: 181 ATSMVAYGKTRVAYLAGRRFDTPVMLDAAGQPTADPRAMWESPTGALRPMADHKGSGLVA 240

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
             ++    L  G    +     +     +   I I+  +L D      +   +  ++ S+
Sbjct: 241 ACEL-LAGLLSGGGTLQPGNPRAGGILNNMTTILIDPARLADMDWLRQEFDAMAGWIRSS 299

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             A   Q ++L G        E  + G  + ++ W  I
Sbjct: 300 PPATAGQPVQLAGDPERRQRHERLQWGTGMAEAEWQGI 337


>UniRef50_A8LPS4 Malate/L-lactate dehydrogenase family protein n=4
           Tax=Alphaproteobacteria RepID=A8LPS4_DINSH
          Length = 339

 Score =  278 bits (712), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 66/335 (19%), Positives = 134/335 (40%), Gaps = 14/335 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++    +    R   + GV    A + A+        G   HG +R   ++ Q  +G I+
Sbjct: 9   LSLPDARDLLFRAFTANGVPEGAARSTADALVAAEAEGQVGHGFSRLEDYVAQARSGKIV 68

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+             DA         ++ +D  I +A + G   +A+  ++H      
Sbjct: 69  AGAEVTITRPAPTTLLVDAGHGFAYPALERAIDEGIAVARELGTAAIAVTRSHHCGALSI 128

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSY 180
           +  +AA+ G + +   N+ A + PWG K    GTNP+  A P   +   ++D+S+S  + 
Sbjct: 129 HVERAAKAGLVAMMVVNAPAAIAPWGGKTPLFGTNPIAFATPRAGSAPLVIDLSLSKVAR 188

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G +   + AG+ +P     D  GN T +         ++P+G  KG+ +++++++++ ++
Sbjct: 189 GKVMNAKKAGKPIPEGWALDAAGNPTTDAEAAL-GGTMVPIGEAKGTALALMVEILSAVM 247

Query: 241 SDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +  A   E       +    G+ Q                 A+L  ++  + +       
Sbjct: 248 TGAALSTEAGSFFSADGPPPGVGQFLTLWRPP--EGAEAFTARLAPLLAQIETM------ 299

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  RLPG      L   + +GI V  +     + L
Sbjct: 300 EGARLPGTRRLAALNAAQAHGIAVPRAYLDGARRL 334


>UniRef50_B9NW20 L-lactate dehydrogenase n=1 Tax=Rhodobacteraceae bacterium KLH11
           RepID=B9NW20_9RHOB
          Length = 337

 Score =  277 bits (710), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 75/331 (22%), Positives = 136/331 (41%), Gaps = 12/331 (3%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
           +++   N VL+  G+D+ ++   A++   +   G  SHG+   P + Q L +G   P A 
Sbjct: 13  EVRELANSVLVKAGLDAHSSAIIADLVWMSERDGPRSHGLRLLPVYAQYLSSGYANPAAS 72

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P    +   + + D       + A    D  I +A ++GI      N +H          
Sbjct: 73  PVIGRAAPGVLRGDGDNGFYQVAALAARDDLIAMARENGIAAFTCANCHHLGALRFDTGP 132

Query: 127 AAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFSYGMLE 184
            AE G + +   NS++++ P G      GTNP+  A   P     + D + SM +   ++
Sbjct: 133 LAEAGLVAMGVVNSLSMVVPQGGVRPTFGTNPMSFACPRPGAEPVVWDQASSMVALMDIK 192

Query: 185 VNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGA 244
           +    G  LP   G D EG  T +P  I + R +LP G  KG+ ++ +++++   L+ G 
Sbjct: 193 MAAAEGHDLPRPAGLDPEGQPTTDPNAILETRGLLPFGEHKGAAIAFLVEVLGAALAGGT 252

Query: 245 SVAEVTQDNSDEY---GISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIR 301
              +     +            IAI+  +  +    D  +QRI   +      + N   R
Sbjct: 253 LSVDNASREAHGALNIKGGATLIAIDPARFGN-AAFDQYVQRICAEI------EGNGTAR 305

Query: 302 LPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +PG       A     G+ V   +  +++ L
Sbjct: 306 VPGDGRLKNRALAEARGVLVSAELLTQLREL 336


>UniRef50_Q21D51 (R)-2-hydroxyacid dehydrogenase n=2 Tax=Alphaproteobacteria
           RepID=Q21D51_RHOPB
          Length = 346

 Score =  277 bits (710), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 80/335 (23%), Positives = 146/335 (43%), Gaps = 7/335 (2%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V  E++++     L++ GV  + AD   ++       G  SHG+ R  R +++++NG 
Sbjct: 1   MIVEAERVRSCAVDALMAAGVLRQDADQQVDLLLEAELRGRPSHGLLRLARIVERIDNGV 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I P A            + D Q  +G + A   ++     A + G+ +  + NANH    
Sbjct: 61  IDPRASGCHHWKAAGFLEVDGQNGLGPVVALSALEAISLRARETGVAVATIVNANHLGML 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
             Y    A +G   I  + S A++ PWG +   +GTNP+ + +P++P   ++DM+ S+ S
Sbjct: 121 AWYAETIARRGLTIIALSISEALVHPWGGRRAMLGTNPVAIGVPASPRPFVLDMASSLVS 180

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +  +   G  +P     D +GN T       K   I P G  KG  + +  +++   
Sbjct: 181 MGQIHDHANRGAPIPGHWALDAQGNATT-DAAAAKAGSIAPFGEAKGYALGLAFEVLVAS 239

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A   +V    D+++      +FI I+             +   ++ + +   AD  
Sbjct: 240 LTGSALGRQVRGTLDSTEVCNKGDVFIVID---GASSAAMAQVIGGYLEAIRAEPPADGF 296

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            A+ +PG            +GI++ D VWA +  L
Sbjct: 297 AAVAIPGDRSIAARQRALADGISIADQVWAGLVRL 331


>UniRef50_Q5E5E9 Ureidoglycolate dehydrogenase n=2 Tax=Vibrionaceae
           RepID=Q5E5E9_VIBF1
          Length = 315

 Score =  276 bits (707), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 72/310 (23%), Positives = 132/310 (42%), Gaps = 16/310 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV++ ++K    R  I+ G+  + A+   ++   + + G  SHG+         + +  
Sbjct: 1   MKVSYYEVKERLIRKFIASGLAWDDANWVTDVLISSEQRGDKSHGIKHAKNIFDVINSEC 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            I  A    I    +I   D Q SIG + AK+ +D AI+ A  +G   ++LR++NH    
Sbjct: 61  YIAQAP--IIHDERSITILDGQNSIGPIVAKQAIDIAIKKAKKYGTAAISLRSSNHLFSL 118

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFS 179
             Y    A    IG   ++S   M    +    IGTNP     P S    ++DMS +  +
Sbjct: 119 SHYVRYIANNNMIGFICSSSSPAMAAPNSLNATIGTNPFAFGAPSSKDPIVIDMSSTNVA 178

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G ++  + A   +PV    D+ GN T       K   + P+G +KG  +  ++D+ +++
Sbjct: 179 RGKIKEYKDAELDIPVSWALDEYGNPTTCAIEALK-GTLSPLGGYKGFALGCMIDIFSSV 237

Query: 240 LSDGASVAEVTQ-----DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           LS  A   ++T      + +D          +++ K I       ++   +  +      
Sbjct: 238 LSGSAFSTQITGTSLHMEEADVNKKGDFLFVLDISKFIQLSEFKIRMDEFIHII------ 291

Query: 295 DENQAIRLPG 304
            E+    +PG
Sbjct: 292 -ESNGGYIPG 300


>UniRef50_A4FEK8 Malate/L-lactate dehydrogenase n=2 Tax=Pseudonocardineae
           RepID=A4FEK8_SACEN
          Length = 375

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 89/350 (25%), Positives = 153/350 (43%), Gaps = 18/350 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V +  L +   R+   RGV ++ A   A        +G+ +HG+    R ++   ++G
Sbjct: 15  VRVDYADLLSFTTRLFAERGVPADRAHTAASALCYGDLTGLEAHGLFNLTRLYLPLFDSG 74

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            + P AQP+ +T LGA    D++R++G  +A + MD A + AA HGIGLV +R+A H+  
Sbjct: 75  RVDPAAQPRVLTDLGACAVVDSRRALGLWSAAEAMDSAADRAAQHGIGLVTVRDATHFGC 134

Query: 120 GGSYGWQAAEKGYIGICWTN--SIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSM 175
            G +  +AAE+G IG+   N     +  P G     +GTNPL VA P+ P    ++DMS 
Sbjct: 135 AGFHTARAAERGVIGVLAGNCGGQRIARPPGGTPAMLGTNPLSVAAPALPGHPFVLDMST 194

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRIL-------PMGYWKGSG 228
           ++   G +      G  +P     D  G    +P   ++    L         G +KG G
Sbjct: 195 TVVPTGRVRTAAARGEPVPPGWLVDSSGAAVTDPAAFDRGEAYLNWLGGDQDTGAYKGFG 254

Query: 229 MSIVLDMIATLLSDGASVAEV------TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
           + +V++++  LL                + +  +  I    IAI    L          +
Sbjct: 255 LGLVVELLGALLPGAGLGPAPEALDGDGRPHGRDDDIGFSAIAIAPRLLRPDRDFAGAAR 314

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + + + +   A  +  +R PG           R G+ V   + A +  L
Sbjct: 315 ALFETINACPPAPGHADVRYPGWWEAERAQSRLREGVPVPAGLHADLVRL 364


>UniRef50_C1XHL2 Malate/lactate dehydrogenase n=2 Tax=Meiothermus RepID=C1XHL2_MEIRU
          Length = 332

 Score =  274 bits (702), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 66/336 (19%), Positives = 142/336 (42%), Gaps = 18/336 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V +  LK A +      G+  + A+A  E+       G   HG+ R  ++  QL+ G 
Sbjct: 1   MRVPYPVLKQAVSSHFQGLGLAPDHAEAFTEVILEAELEGNLGHGLTRIAQYTAQLQAGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P  Q +   +   +    A  + G +     +     +A + G   +A+R A H    
Sbjct: 61  LNPRPQMRLERTKPGVAVLHADGAPGPVAGLFAVQALAPMAREQGSAALAVRGAGHSGVL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
            +Y  + A++G + + + N+   + P       +GTNP+ +  P+ P   ++D S+S+ +
Sbjct: 121 SAYVGRLAQEGLVALAFANTPPAIAP----GPVLGTNPIALGAPAEPQPVIIDTSISVVA 176

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +      G  +P     D EG  T +     +   +LP+G  KG  ++++++++A  
Sbjct: 177 RGKIIAAAKKGEPIPPGWALDKEGRPTTDAKAALE-GSLLPIGEGKGFALAVLVEILAGA 235

Query: 240 LSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L+      E+       +       + +A +      G     ++ ++++ + +A     
Sbjct: 236 LAGDVLSPELPLPWMPPAQAAKPGLLLLAFDPAAFGPG--YRGRVAQLIEALKAA----- 288

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               R+PG     L  +    G+ V+ ++ A++  L
Sbjct: 289 --GGRIPGARRAALREKALAEGLEVNQTLQAELGTL 322


>UniRef50_B6A4N6 Malate/L-lactate dehydrogenase n=6 Tax=Proteobacteria
           RepID=B6A4N6_RHILW
          Length = 344

 Score =  274 bits (702), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 18/339 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T   L      +    G+++  A A A +          SHG+ R    ++ +++G + 
Sbjct: 6   LTIADLHGRVEAIFRKAGLNAVQAGALARVIVAGERDACKSHGIYRIEGALRTVKSGKVK 65

Query: 63  PDAQPKR-ITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           PDA P+  +    AI + +A     N   +  +    E     GI  + + +  H+    
Sbjct: 66  PDAVPELDLNEGSAIVKVNADGGFANAAFELGVPALAERTRKLGIAALVINDCTHFSALW 125

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFS 179
                  ++G  G+    S A + P G  +  +GTNP     P       + D + S+ +
Sbjct: 126 PEVEAVTKEGLAGLVMCPSYATVAPAGGNKPLLGTNPFAFGWPRKDTSPYVFDFATSVAA 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +E++R AG+QLP     D +G+ T +P        +LP G  KGS +  +++++A +
Sbjct: 186 RGEIELHRRAGKQLPEGWAIDADGHPTTDPEAAL-AGAMLPFGGHKGSAIGTMIELLAGI 244

Query: 240 LSDGASVAEVTQDNSDE---YGISQIFIAIEVDKL---IDGPTRDAKLQRIMDYVTSAER 293
           +    +  EV              ++ IA+          G    A+ + + + +  +  
Sbjct: 245 MIGDLTSPEVLDYLGTTTLAPFHGELIIAMSPQAFAAGRPGDPF-ARAELLFEAIVGS-- 301

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                  RLP         ++   G+ +  +    +  L
Sbjct: 302 -----GARLPSQRRFAAREKSETEGVVLTAAELELLDRL 335


>UniRef50_Q11D61 Malate/L-lactate dehydrogenase n=1 Tax=Chelativorans sp. BNC1
           RepID=Q11D61_MESSB
          Length = 360

 Score =  274 bits (701), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 66/334 (19%), Positives = 129/334 (38%), Gaps = 13/334 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +++T E  +    R L+  G   E A             G    G+NR    I +    +
Sbjct: 21  VRLTVEGARDLTRRALVGAGYSVEEAKIIQSQLVTNALDGYGPAGLNRALAIIMEPRARE 80

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             P    + +         D   ++G L   +  + A+E A   G  +V + N     R 
Sbjct: 81  --PRRAIRIVHETPNSALLDGGNNVGYLACWRASEVALEKARATGFAVVGVNNCPFSGRN 138

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
             Y    A  G++ +  T+ +  + P G ++  +GTNP+  A P       +VDMS    
Sbjct: 139 AHYVEPLARAGFVALHTTSGMPHVLPLGGRKAVMGTNPICFAFPTKGRDPIIVDMSTLAI 198

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
            +G + ++   G  LP   GFD +GN T +     K   + P G  KG  +S+V+ ++  
Sbjct: 199 MWGDVLLHARTGEPLPEGVGFDSDGNPTTDASKAAKGG-VAPFGGHKGYALSLVVQIL-G 256

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++       ++ D +       +FI ++    +     +  L   +  + S  R +   
Sbjct: 257 LMAGAHLPRGLSSDYAG------LFIVVDPKLTLPAGAFEEHLDLFIRDLKSTPRREGVN 310

Query: 299 AIRLPGHEFTT-LLAENRRNGITVDDSVWAKIQA 331
            I +P          +   + + +D ++ + ++ 
Sbjct: 311 DILVPSERAFRQRRIQQEADVVDIDVALHSALEQ 344


>UniRef50_A6UCA9 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UCA9_SINMW
          Length = 356

 Score =  273 bits (699), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 93/338 (27%), Positives = 146/338 (43%), Gaps = 15/338 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           V  + L+A     L + G    +A A        +  GV SHGV     + + L  G + 
Sbjct: 7   VAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVLRGGRVN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
                    +  A    D   ++G+  A   MD+AIELA + GIG V +  ++H+   G+
Sbjct: 67  GTPNLSVRRTAAATAVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSHFGAAGA 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMFSY 180
           Y   AAE G IG   TNS  V+ P+  +E   GTNPL  A PS      ++DM+ S    
Sbjct: 127 YARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTNPLAFAAPSGGARPWLLDMATSSIPL 186

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGY----WKGSGMSIVLDMI 236
             L + +  G  LP     D+ G  T EP    + R +LP+G     +KG+ ++ V  ++
Sbjct: 187 NRLLLCKSLGMSLPAGVAVDEAGQPTTEP---FEGRTLLPLGGVDFSFKGAALAGVATLL 243

Query: 237 ATLLSDGASVAEV-----TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
           + +L        +     T D S    +    +AI+ D+       D  +   ++ + SA
Sbjct: 244 SAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEALRSA 303

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
             A E   +  PG     + A  R+NGI +D    A +
Sbjct: 304 -PAQEGCEVLAPGDREWRVEAARRQNGIPIDPDTAAFL 340


>UniRef50_A9I6A1 Putative malate dehydrogenase n=1 Tax=Bordetella petrii DSM 12804
           RepID=A9I6A1_BORPD
          Length = 312

 Score =  270 bits (691), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 74/304 (24%), Positives = 140/304 (46%), Gaps = 17/304 (5%)

Query: 34  ARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKM 93
            +T+  GV SHG+ R P ++ +L +G ++   Q + + S  A  Q    + +G + A + 
Sbjct: 1   MQTSLWGVDSHGIARLPHYLNRLAHGSVLARPQVRVVRSGPATAQVHGGQGLGIVVAHRA 60

Query: 94  MDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECR 153
              A+E+A + G+  V + +++H    G Y   AAE G +G+ +T+S A+  P+G     
Sbjct: 61  NRLAMEIAREAGVAAVGVSDSSHCGAVGLYSRAAAEAGLVGLAFTHSDAIAAPFGGHAPF 120

Query: 154 IGTNPLIVAIPS--TPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGV 211
           +GTNP+ VA+P    P   +DM+ +   +  +   R  G  LP     DD G    +P V
Sbjct: 121 LGTNPISVAVPRQDGPPACLDMASTAIPWNRVMNARREGHALPEGVALDDTGRDATDPLV 180

Query: 212 IEKNRRILPMG----YWKGSGMSIVLDMIATLLSD---GASVAEVTQDNSDEYGISQIFI 264
                 + P+G     +KG G++++++++   L+    G  ++ + +       +   FI
Sbjct: 181 AR---ALRPLGGPQQGYKGYGLALMIELLCGPLNGNPFGPHISPMYEQLDKARRLGAFFI 237

Query: 265 AIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDS 324
            I+  +   GP   A + ++   + +          R+PG           R GI V+  
Sbjct: 238 VIDPARFAGGPLLAAVVAQMAAELAAQPGQP-----RMPGDPEQAAQVSRLRGGIPVEPG 292

Query: 325 VWAK 328
           +W +
Sbjct: 293 LWQE 296


>UniRef50_A6UGA2 Malate/L-lactate dehydrogenase n=9 Tax=Alphaproteobacteria
           RepID=A6UGA2_SINMW
          Length = 345

 Score =  270 bits (690), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 73/335 (21%), Positives = 131/335 (39%), Gaps = 18/335 (5%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L      +    G++   A A A +          SHG+ R    ++ ++ G + PDA 
Sbjct: 11  ALHERVEAIFRKGGLNVVQAGALARVIVAGERDACKSHGIYRIEGALRTVKAGKVKPDAI 70

Query: 67  PKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           P+ I     AI + +A     N   +  +    E A   GI  +A+ +  H+        
Sbjct: 71  PEIIAQEASAIVKVNAGGGFANPAFELGLPVLAERARTQGIAALAINDCTHFSALWPEAE 130

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGML 183
               +G  G+    S A + P G  +  +GTNP     P    P  + D + S+ + G +
Sbjct: 131 ALTGEGLAGLVMCPSYATVAPTGGNKPLLGTNPFAFGWPRAGRPPYVFDFATSVAARGEI 190

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDG 243
           E++R AG+ LP     D +GN T +P        +LP G  KGS +  +++++A ++   
Sbjct: 191 ELHRRAGKALPDGWAIDAKGNPTTDPEAAL-AGAMLPFGGHKGSAIGTMIELLAGIMIGD 249

Query: 244 ASVAEVTQDNSDE---YGISQIFIAIEVDKL---IDGPTRDAKLQRIMDYVTSAERADEN 297
            +  EV              ++ IA   +       G    A+ + + + +         
Sbjct: 250 LTSPEVLDYLGTTTLAPFHGELIIAFSPEAFAAGRPGDPF-ARAEMLFEAIV-------G 301

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           Q  RLP        A++   GIT+  +   ++  L
Sbjct: 302 QGARLPSQRRFAARAKSEAEGITLTAAEVEQLDRL 336


>UniRef50_Q168E2 Malate/L-lactate dehydrogenase, putative n=15 Tax=Bacteria
           RepID=Q168E2_ROSDO
          Length = 331

 Score =  269 bits (688), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 70/335 (20%), Positives = 136/335 (40%), Gaps = 22/335 (6%)

Query: 4   TFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIP 63
           + E ++A   + L++ G     A   A         G    G+     +  QLE G +  
Sbjct: 5   SLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDG 64

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
            A P       A    +A          + +  A++ A   G   +A+ +A+     G +
Sbjct: 65  HAVPDVTNPRPAAIHVNANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYF 124

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM---VDMSMSMFSY 180
             Q A+ G IGI +TN+  ++   G K   IGTNP+  ++P     +    D S +  + 
Sbjct: 125 TEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIAFSVPDGAGGVAMQFDQSTTTVAL 184

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
           G + + +  G+Q+P+    D +G  T +P    +   ++ +G  KG G  ++ +++A  +
Sbjct: 185 GKITMAKALGQQIPLGWALDAQGKPTTDPQAALE-GSLVSVGGHKGWGFGLMAEILAAGM 243

Query: 241 SD---GASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           +      SV  +       + + Q +I I+      G     +L  +      ++ A ++
Sbjct: 244 TGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQ---SGEAFAERLAAL------SQAATKD 294

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           +  R+PG     +        + V D VW ++Q L
Sbjct: 295 EGARMPGQSRQIMQE------VEVVDQVWNRLQEL 323


>UniRef50_C5CKP7 Malate/L-lactate dehydrogenase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CKP7_VARPS
          Length = 355

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 66/337 (19%), Positives = 130/337 (38%), Gaps = 14/337 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
              E LK     +L   G+ +   D+ A         G  +HG+     ++++LE+G + 
Sbjct: 9   YRAEALKDYAGALLQKAGLAAPMTDSVARTLVEGDLLGHDTHGLALLAGYVKELESGGMT 68

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            +  P+ ++   A   WD +R  G     + MD  +  A + G   + +R ++H      
Sbjct: 69  REGAPEVLSDRPAAVLWDGKRLPGPWLMDQGMDLLVPRARELGTASLVIRRSHHIACLAV 128

Query: 123 YGWQAAEKGYIGICWTNSI--AVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMFS 179
           Y  +A E+  + +   +    A + P+G  +     NPL +  P S    MVD+S S+ +
Sbjct: 129 YMLRALEEDMLMLLACSDPNTASVAPFGGTQAVFTPNPLAMGFPLSQGGVMVDISASITT 188

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMG----YWKGSGMSIVL 233
            GM    R AG     +   D  G  +  P V+       +LP+G      KG GM++++
Sbjct: 189 NGMSNRKRAAGETFAEEWLIDAAGKPSNNPQVLFDQPPGTLLPVGGLSHGHKGYGMALLV 248

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
           + +   L+            +  +         ++           ++  +     +   
Sbjct: 249 ETLTAGLAGHGRADPPEGWGATVHVTLH-----DLHAFGGKEAFLRQMDHVAAQCRNNRP 303

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
            D  + +R+PG           +NG+ +  S+   +Q
Sbjct: 304 IDPARPVRMPGEGGLKRRDAQSKNGVRLHPSIARSLQ 340


>UniRef50_Q3S8E9 Putative malate/L-lactate dehydrogenase n=1 Tax=Paracoccus
           pantotrophus RepID=Q3S8E9_PARPN
          Length = 359

 Score =  268 bits (685), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 71/334 (21%), Positives = 119/334 (35%), Gaps = 15/334 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLE--NG 59
           K+  ++ +    RV+ + G  +  A A A+        GV   G++R            G
Sbjct: 32  KIAIDEARVLVERVMEATGYGAPEAAAIADHLLDCELRGVAMGGLSRAISVADHFAQHRG 91

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
            I      +           +    +G L   K  + AIE A   GIG+V    A     
Sbjct: 92  RID---TLRIQRETPFSAALEGGNRVGYLLGAKATEIAIEKARASGIGMVTGHCAIFSGM 148

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
              Y  +    G++ +  ++   ++ P G  E   GTNP+    P ++   + D+  S  
Sbjct: 149 LSYYVERITAAGFVAVATSSVGPMVAPEGGTEALFGTNPIAFGFPSASEPVIWDIGTSRI 208

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
                 +    G+ LP D  FD  G  T++P            G  KGSG+++V+ +   
Sbjct: 209 MLAETILAARLGQALPEDVAFDKSGQPTRDPHAAL-AGAFRVWGGHKGSGLALVVQLF-G 266

Query: 239 LLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQ 298
           L++    V E          I     AI+     D      K+    D + +    +   
Sbjct: 267 LMAGTPVVQETYG------SIGLFLQAIDPALFGDPEDFATKVAEFSDLLRANRPVEGGP 320

Query: 299 AIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQA 331
           A+RLP         E    G I V + V  ++ A
Sbjct: 321 ALRLPFERSRQRRKEQLARGYIEVAEEVLRQLHA 354


>UniRef50_A1SWJ6 Malate/L-lactate dehydrogenase n=3 Tax=Proteobacteria
           RepID=A1SWJ6_PSYIN
          Length = 339

 Score =  263 bits (674), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 77/337 (22%), Positives = 143/337 (42%), Gaps = 15/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +T E++       L+S+G + E A A A         G  SHG+ R P +I  L++  
Sbjct: 6   INLTLEEIYDLAKTALLSQGANEENAAAIANTVTIAERDGAISHGLFRIPGYIVGLQSKK 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           ++  A P+       I + DA+     LT +  +   I+ A   G+  VA++N++H+   
Sbjct: 66  VVGTATPEIEEVTPIIFRCDAKNGYAPLTHEHCLPPLIDAAKKFGLAAVAIQNSHHFAAL 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
                + +E G IG+   + +  + P G K    GTNP+  + P       ++DM+ S  
Sbjct: 126 WPEVEKMSEAGLIGLTTVSYLPWVAPAGGKTPIFGTNPMAFSWPRAGKNPVVIDMATSSM 185

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G + +    G ++P+  G  + G LT +   I K   +LP G  KGS +++++++++ 
Sbjct: 186 AMGEVMIAARDGYEVPLGTGLSESGELTTDAAEIVK-GVLLPFGGHKGSALALMVELLSG 244

Query: 239 LLSDGASVAEVTQDN---SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
            L       E  + +          Q  +AI  D L    T   +  R  +      + D
Sbjct: 245 PLVGETFSYETQERDKAEEGPARGGQFILAISPDILSGKNT-SEQTDRFFE------KYD 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             +  R PG         +     +V+  +   I+ L
Sbjct: 298 AIEGARTPGARRHKNRENSGPR--SVNADLVKTIEQL 332


>UniRef50_C1YJN3 Malate/lactate dehydrogenase n=1 Tax=Nocardiopsis dassonvillei
           subsp. dassonvillei DSM 43111 RepID=C1YJN3_NOCDA
          Length = 377

 Score =  263 bits (673), Expect = 7e-69,   Method: Composition-based stats.
 Identities = 92/348 (26%), Positives = 156/348 (44%), Gaps = 18/348 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPR-FIQQLENG 59
           ++V  + L A    V   RG+  + A   A        +G  SHG+    R ++  L+ G
Sbjct: 16  VRVRHDDLVAFAAGVFTDRGLPPDRAAEAARALCHGDLAGPRSHGLANLTRLYLPLLDEG 75

Query: 60  DIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMR 119
              P A+P+ +  LGA   WD++R++G   A + MD A E AA HGIGLV++R A H   
Sbjct: 76  RADPAAEPRVLADLGAAVLWDSRRALGLWAASEAMDLAAERAARHGIGLVSVRGATHLGC 135

Query: 120 GGSYGWQAAEKGYIGICWTNS--IAVMPPWGAKECRIGTNPLIVAIPST--PITMVDMSM 175
            G +  +AAE+G +G+  +N     +  P G     +GTNPL VA P+   P  ++DMS 
Sbjct: 136 AGYHALRAAERGMVGLVASNCGRQRIARPPGGAVAMLGTNPLSVAAPAGEHPPFLLDMST 195

Query: 176 SMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR-ILPMGY----WKGSGMS 230
           +    G +      G  LP     DD G    +P   +  R  ++ +G     +KG G+ 
Sbjct: 196 TAAPTGRIRQAAREGLALPEGLLCDDTGAPVTDPAAFDAGRAHLMWLGGEAGRYKGFGLG 255

Query: 231 IVLDMIATLLSDGASVAEV------TQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRI 284
           +++++++ L+    +             +  +  I     AI    L  G   DA+   +
Sbjct: 256 LMVEVLSALVPGAGTGPHPDALDGDGGPSGRDDDIGFFVAAIAPGALRQGADDDAR--EL 313

Query: 285 MDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
              + +    D +  +R PG        E R  G+ ++  ++A++  L
Sbjct: 314 FGALLACPPTDPDAPVRYPGWHEYHRARELRLAGVPLEAELYAELAEL 361


>UniRef50_A5VTX8 Malate/L-lactate dehydrogenase family protein n=1 Tax=Brucella ovis
           ATCC 25840 RepID=A5VTX8_BRUO2
          Length = 319

 Score =  263 bits (672), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 75/340 (22%), Positives = 133/340 (39%), Gaps = 44/340 (12%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +T E+L A    +    G+++  A A A +          SHG+ R    ++ ++ G +
Sbjct: 6   NLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKV 65

Query: 62  IPDAQPKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            PDA P+ +     AI + DA+    N   +  +    E A  HG+              
Sbjct: 66  KPDAVPELVAQEASAIVRVDAKGGFANPAFELGVPVLAERARSHGLA------------- 112

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMF 178
                        G+    S A + P G  +  +GTNP     P    P  + D + S+ 
Sbjct: 113 -------------GLVMCLSYATVAPTGGSKPLLGTNPFAFGWPRRDNPPYVFDFATSVA 159

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           + G +E++R AG+QLP     D +G  T +P    +   +LP G  KGS +S +++++A 
Sbjct: 160 ARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALE-GAMLPFGGHKGSAISTMIELLAG 218

Query: 239 LLSDGASVAEVTQDNSD---EYGISQIFIAIEVDKL---IDGPTRDAKLQRIMDYVTSAE 292
           ++    +  EV              ++ IA   +       G    A+ +   + +    
Sbjct: 219 IMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPF-ARAEAFFEAIV--- 274

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                Q  RLP     T  A ++  GIT++ +    +  L
Sbjct: 275 ----GQGARLPSQRRFTARAASQSEGITLNKAEIDYLDQL 310


>UniRef50_Q1YHD0 Putative malate/L-lactate dehydrogenase n=1 Tax=Aurantimonas
           manganoxydans SI85-9A1 RepID=Q1YHD0_MOBAS
          Length = 348

 Score =  262 bits (671), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 70/338 (20%), Positives = 141/338 (41%), Gaps = 14/338 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +  +  L    +  L + G+D+  A+  AE        G  +HG+   PR++++LE G +
Sbjct: 4   RYDYRALIGYAHDALAASGLDAGHAEIVAETLVEGDLLGHSTHGLALLPRYLRELEAGHM 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
               +P  +   GA   W      G +  ++ +    + A D G+  VA+  ++H     
Sbjct: 64  TKAGEPTIVRDHGASAAWGGNYLPGPVLVRRALALCTDRARDAGVATVAIGQSHHVACLA 123

Query: 122 SYGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIP-STPITMVDMSMSMF 178
           +Y     ++G   I  ++S A   + P+GA E     NP+    P      +VD+S S+ 
Sbjct: 124 AYLKAVTDEGMAAIIASSSPATASVAPFGAVEGIYSPNPIAAGWPTGGDPVLVDISASIT 183

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPG--VIEKNRRILPMG----YWKGSGMSIV 232
           +  ++      GR+LP       +G  + +P          +LP+G      KG  + ++
Sbjct: 184 TNSLVSERVEEGRRLPGAWMIGPDGTASDDPALLTARPAGALLPLGGTEYGHKGFALGLI 243

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++M+   L+          D  D++G S   + ++ +        + +   +      A+
Sbjct: 244 VEMLTAGLAGHG-----RADAPDQWGASVFVMVVDPEHHGGRAAFERQTGFMAGAARGAK 298

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
             D   A+RLPG     L  +   +G+ + D + A+++
Sbjct: 299 VPDGASAVRLPGERALRLRRQQMADGVVLSDELLARLR 336


>UniRef50_B7G5R1 Dehydrogenase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G5R1_PHATR
          Length = 392

 Score =  262 bits (669), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 77/334 (23%), Positives = 131/334 (39%), Gaps = 17/334 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + V+ ++ +    + L   G D E A   AE+       G  + G+     +   L    
Sbjct: 61  VHVSVQEARETTAKALQMIGWDHEDAALQAEIMTAAELCGN-NQGL--VKMYQPALMAPS 117

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHG-IGLVALRN-ANHWM 118
                +P            +A +S G L A    D A+  A  +G I +V   N +    
Sbjct: 118 PNA-GKPTVERETPTSAVVNANQSPGMLAAVNAADLAVHKATTNGPIAIVTSYNTSTSSG 176

Query: 119 RGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMS 176
           +   Y  + A KG IGI   NS   +      +   GTNP+ V IP         DM+ S
Sbjct: 177 QLAFYVERMARKGIIGIAMANSPEFVAAAQGGKPVFGTNPIAVGIPQKDAVPFTFDMATS 236

Query: 177 MFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMI 236
             +   L  ++     LP +  +  +G  T +   +     I   G  KG+G+++ ++++
Sbjct: 237 AIALFGLLTSKAQNTPLPSNVAYGKDGGWTTDAAEVLDGGAIATFGGHKGAGLALCIELL 296

Query: 237 ATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           A  LS  A +  V    S +     +FIAI+ + L D    ++K   ++  V ++     
Sbjct: 297 AGALSGSAVLGLVESKKSAKS-WGHLFIAIDPNALTD--DFESKTASVIAAVKAS----- 348

Query: 297 NQAIRLPGHEFTTLLAENRRNGI-TVDDSVWAKI 329
              IR+PG     +  E +  GI  V   +W  I
Sbjct: 349 GDNIRIPGERSANMSEERKAVGIMPVPQKIWESI 382


>UniRef50_Q7WEF1 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella
           bronchiseptica RepID=Q7WEF1_BORBR
          Length = 356

 Score =  260 bits (666), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 68/337 (20%), Positives = 127/337 (37%), Gaps = 13/337 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +  +  +    R+    G++   A A A    R    G  SHG+     ++  L +G 
Sbjct: 8   LHIDCDSAQHFTARLFERNGLEPAKAAAVARSLVRADMMGHDSHGLALASWYLDALADGQ 67

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +     P+ I   GA   W+ QR  G    ++ M+  +E    HG     + N+ H    
Sbjct: 68  MASQGAPEVIADRGACFAWNGQRLPGAWLIERAMEAGVERVRTHGSATCTIANSFHAGAL 127

Query: 121 GSYGWQAAEKGYIGICWTNSIA--VMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSM 177
            +Y  Q   +G + I   +  A   + P+G  E     NPL   IP++    ++D+S S+
Sbjct: 128 AAYLEQLTAQGLLAILTCSGPASRAVAPFGGTEALFSPNPLAAGIPTSQAPMLMDISCSI 187

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEP-GVIEKNRRILPMG----YWKGSGMSIV 232
            +          GR  P       EG  T +P  V++    +LP+G      KG  M+++
Sbjct: 188 TTTNRTRQLARQGRAFPAAWALTREGEPTDDPRQVVDHGGSLLPVGGVDHGHKGYAMALM 247

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292
           ++ +   LS                  +     ++ +          +   +    T+  
Sbjct: 248 VEALTQGLSGYG-----RNAAPTGIVTNIYLHILDPEAFGGRAAFLRETDWMAASCTANP 302

Query: 293 RADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
                 A+R+PG +    LA  R  G+ +   + A++
Sbjct: 303 PRPGVSAVRVPGQQAQARLAAARAQGLRIAAGLAAEL 339


>UniRef50_Q0RXU9 Probable malate/L-lactate dehydrogenase n=1 Tax=Rhodococcus jostii
           RHA1 RepID=Q0RXU9_RHOSR
          Length = 349

 Score =  259 bits (662), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 70/295 (23%), Positives = 128/295 (43%), Gaps = 15/295 (5%)

Query: 22  DSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDA 81
           D   A   AE   +    G+ SHG+ R P ++++++ G   P+A    ++  G +   D 
Sbjct: 22  DRTRAATTAECIVQADLWGIGSHGLLRLPYYLERMQAGGYPPEADLVTVSDTGPVVALDG 81

Query: 82  QRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSI 141
              +G+    +  + A E  A +G+  V++ N+ H    G Y   A + GYI + ++N  
Sbjct: 82  GGGLGHWQLWRAAELAAERCATYGVAAVSVGNSGHCGALGIYTRAAIDTGYIALTFSNGP 141

Query: 142 AVMPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFD 200
           AVMPPWG  +  + T+P+   IPS P   ++D++ S  + G +  +   G QLP     D
Sbjct: 142 AVMPPWGGNKPLLSTSPIAAGIPSRPTPAIIDLATSAVARGKIAAHAQNGDQLPDGWALD 201

Query: 201 DEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVT-----QDNSD 255
             G  T +P    +   + P+G  KG  ++ +++ +A          +V       D   
Sbjct: 202 AHGEPTTDPQAALR-GMLSPLGGAKGFALAFLVEALAGGAVGPHLSVDVPDMFDDSDAKH 260

Query: 256 EYGISQIFIAIEVDKLI-DGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTT 309
              I  + + ++  +L   G     ++ R+ + V            RLPG   + 
Sbjct: 261 PQRIGHLIVTVDPARLGSSGNGAQERIDRLANLV-------GEHGGRLPGARRSA 308


>UniRef50_Q98CD3 Mll5197 protein n=2 Tax=Mesorhizobium RepID=Q98CD3_RHILO
          Length = 333

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 13/335 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+++ +Q +       +  G + E A +           G+ + G++ F  +++ LE G 
Sbjct: 1   MQLSLDQARGLCRMAALGAGANEEAAQSLTASIIAAEAEGLSTVGLSHFIDYLEALEAGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  +A P       A+   DA+  + +    + +D   + A   G+ + + +NA      
Sbjct: 61  IDGNADPVITRPALAVYLSDARGGLAHTGFDRTIDDLAKAAKLFGVAIFSQKNAYTCGAL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMSMSMF 178
           G +  + A +G +    TN  AV+   G+ +    TNP+  A P+      ++D S S  
Sbjct: 121 GYFTGRLAAQGLVSFAATNGPAVLAGSGSVKPVYCTNPMSFAAPAADGAPLVIDQSSSAT 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++  +      G+++P     D  GN T +P    K   +L  G  +G+ ++++++++A 
Sbjct: 181 AFVNIRKAAEDGKKIPEGWALDASGNPTTDPAAAMK-GAMLAFGGQRGANIALMVEVLAA 239

Query: 239 LLSDGASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            +S       A       D  G     +AIE   L      + +++  +D +        
Sbjct: 240 GISGANWSLDAPWFTGGPDSPGTGLFVLAIEPKLLDP--DFEQRMKDQLDRLRRRF---- 293

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              + +PG        + +  GIT   +V  +I  
Sbjct: 294 --GVHVPGRARAEAAEKAQARGITAPKAVVQRISE 326


>UniRef50_Q46QD8 Malate/L-lactate dehydrogenase n=4 Tax=Burkholderiales
           RepID=Q46QD8_RALEJ
          Length = 352

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 74/337 (21%), Positives = 130/337 (38%), Gaps = 12/337 (3%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +   + L+   + V  S GV  E A   A    R+   G  +HG+ R P ++ +L  GD 
Sbjct: 4   RWNVQGLEQWTSAVFESCGVAPEHAVEAAAALVRSELRGYKTHGMTRVPSYVDRLRAGDF 63

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
            P A      +       DA  ++G +     +   +E        LVA+++  H    G
Sbjct: 64  NPRATMS-HRAFAGGIVLDADGAMGQVAGPHAVRLGLEALESSASVLVAVQSCGHLGALG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
            +   AAE G   +    +  V+   G     IG NP+      P     + D++ S+ +
Sbjct: 123 IHALLAAEAGAFCMVGQRTPPVLGMEGFSGPAIGHNPIAFGCPLPGQAPIVFDVACSVAA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G + +    G+ +P     D +G  T +         +LP G  KG G++++++ +A  
Sbjct: 183 RGHILLAAREGKPIPEGWALDADGQPTTDAQRAL-AGSLLPTGGHKGIGIAMMVECLAGA 241

Query: 240 LSDGASVAEVTQDNSDEYGI----SQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           L+  A      +++    G           ++ +               M   T    A 
Sbjct: 242 LAATADSLSPERNHVGSGGAVGRQGGFVWLVKPEAFSGQGVF----ADYMAQWTGNYLAA 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                RLPGH   TL  E R +GI + D++  ++ AL
Sbjct: 298 GGGDARLPGHRGDTLEREGRAHGIALPDAIARELGAL 334


>UniRef50_A4SB62 Predicted protein n=4 Tax=Mamiellales RepID=A4SB62_OSTLU
          Length = 330

 Score =  256 bits (654), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 81/334 (24%), Positives = 143/334 (42%), Gaps = 19/334 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENG-DI 61
           V  E+LK    + +   G + + A    ++       G  + G+ +         NG  +
Sbjct: 2   VPIEELKTTTTKAIRGIGYNEKDAKVILDVLMYAQLRGN-NQGIIKVTT------NGLAM 54

Query: 62  IPDAQPKRI-TSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRN-ANHWMR 119
            PDA+P  +          D +++ G L   +    A E A +HG G+V   N +     
Sbjct: 55  APDAEPMVVTHETKLSAAIDGKKTQGMLVLAEATRVAHEKAKEHGFGIVGTCNTSTSTGA 114

Query: 120 GGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI-TMVDMSMSMF 178
            G Y    A++G I IC+  S   + P G+ +   GTNP+ V IPS+    ++DM+ S +
Sbjct: 115 LGYYCKSVADQGMISICFAQSPEFVAPAGSSKAIFGTNPIGVGIPSSEGAMVLDMATSAY 174

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPM-GYWKGSGMSIVLDMIA 237
           S+  +   + AGR+LP     D  G LTK+P  +     I    G +K S +++V++++A
Sbjct: 175 SWFGVLEAKTAGRELPDGAAQDKNGVLTKDPNEVLDGGAIRTFDGGYKSSNLALVIELLA 234

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
             L   A   ++            + + I+   L      +     +M+ V +A +    
Sbjct: 235 GPLVGAAIEGKLAAK-----NWGNLIMVIDPKMLG-QADFEKNAAFVMNRVRNAPKQPGV 288

Query: 298 QAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQ 330
            AI LPG     +   N   G I V+ ++W  ++
Sbjct: 289 DAINLPGERGDAIAKANEAKGEIDVETNLWNNLK 322


>UniRef50_Q1QWQ4 Malate/L-lactate dehydrogenase n=4 Tax=Gammaproteobacteria
           RepID=Q1QWQ4_CHRSD
          Length = 355

 Score =  255 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 68/334 (20%), Positives = 127/334 (38%), Gaps = 15/334 (4%)

Query: 8   LKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA-Q 66
           L      +    G  +E A+  A +       G ++HGV     ++  L+ G+   D  Q
Sbjct: 9   LTDLLTALFAEAGATAEVAETTASILVEGDLLGHHTHGVKLAKGYLNDLKAGNACGDHRQ 68

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
                S       D    +G     + +  A + A   GIG+V L+ ++H     +Y   
Sbjct: 69  LALTESSPVAAMIDGHYVLGPYLVTRALAHARQAADGFGIGIVTLKRSHHIACLAAYLRP 128

Query: 127 AAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFSYGML 183
             E+G + I  ++  AV  + P+G        +PL + IP      ++D+SMS  + G +
Sbjct: 129 LVEQGLVPIVLSSDPAVASVAPYGGTTPVYTPDPLAIGIPGREHPLLIDVSMSSITNGTV 188

Query: 184 EVNRLAGRQLPVDGGFDDEGNLTKEPGVIE--KNRRILPMGY----WKGSGMSIVLDMIA 237
              R  G +L       + G ++ +P          ILP+G      KG  + ++++ + 
Sbjct: 189 NKTRAEGGKLAHPAILTNRGTVSDDPEDFFTTPPGSILPLGGQAFGHKGFALGLMVEALT 248

Query: 238 TLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           + L          +D   ++G S   + I+  +         +   +      +ER D  
Sbjct: 249 SALGGFG-----RKDAPTQWGASATVMVIDPARFGGTQAFLDETDFLARQCLDSERVDPE 303

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             +RLPG           R+GI +   V   ++ 
Sbjct: 304 VPVRLPGQSGLAKRQRYLRDGIPLPGDVVDALRE 337


>UniRef50_Q96YT3 318aa long hypothetical malate dehydrogenase n=1 Tax=Sulfolobus
           tokodaii RepID=Q96YT3_SULTO
          Length = 318

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 77/335 (22%), Positives = 139/335 (41%), Gaps = 32/335 (9%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  ++ ++    +L  RGV  E     A+ F      G YSHG+ R    ++ ++ G 
Sbjct: 1   MKIKVKEAESLVESILKKRGV--ENPSIIAKHFVEAELRGHYSHGLQRVIPLVKGIDLGT 58

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I    Q   I        +DA  SIG L    + +   E        L+A+RN++H    
Sbjct: 59  IRKTVQLTEIKREDNAVLYDANYSIGILVWHYLTESPKET-------LIAVRNSSHIGFL 111

Query: 121 GSYGWQAAEK-GYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFS 179
           G Y  + A + G   I   N+   +   G  +  I T P+ +AIP   I ++DMS+S  +
Sbjct: 112 GYYTRRIAMRLGKPAIMIGNAEPAVVKPGTAKKIISTTPISIAIPCEKIVVLDMSLSPIA 171

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
            G +   +  G ++P     + +G +T +P    +   +LP+G  KG  + I L+++ + 
Sbjct: 172 RGKIIEAKRKGEKIPYGVTVNKDGEITTDPDEALQGG-LLPIGGMKGFFLMITLELLVSF 230

Query: 240 LSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADEN 297
           L+  A   EV    D +      +  I +   +L       + L++ ++           
Sbjct: 231 LTGSALATEVQGVLDTTKSPNKGEFMIIL--PRLQSDCHGLSVLKQFVE----------- 277

Query: 298 QAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               LPG     +L  +    I +D+ ++     L
Sbjct: 278 ---YLPGEHSDEMLKRDE---IDIDEKLYNIFVKL 306


>UniRef50_Q5LT11 Malate/L-lactate dehydrogenase family protein n=1 Tax=Ruegeria
           pomeroyi RepID=Q5LT11_SILPO
          Length = 350

 Score =  251 bits (641), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 75/339 (22%), Positives = 140/339 (41%), Gaps = 21/339 (6%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           ++   +++   + +  +   D + A+  A      + SGV SHGV R   +  Q+E+G +
Sbjct: 16  RLPAAKVQTRLSAIFQALRFDPDIAEEVAAHLVDASLSGVESHGVMRVLEYAAQVESGYL 75

Query: 62  IPDAQPKRITS-LGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            P  +P+ +    G   + +A   IG    +   D   + A   G+  +++R+  H  R 
Sbjct: 76  TPSGRPQVLRDDTGGPTRIEAGGGIGIPALRLAYDTCCDEARARGLSALSIRHVGHTGRH 135

Query: 121 GSYGWQAAEKGYIGICWT----NSIAVMPPWGAKECRIGTNPLIVAIPSTP--ITMVDMS 174
           G++   AAE G + IC       +   + P G     + TNP  + IP       ++D +
Sbjct: 136 GAFAEAAAEAGCLTICLGGGNRQTWRQVAPHGGARAMLPTNPWCIGIPGGDRGPVVLDFA 195

Query: 175 MSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLD 234
            S  + G +   R AG  LP     D  G+ T+ P        ILP G  KG G++++ +
Sbjct: 196 TSKIAGGWIYAARSAGALLPEGCVIDAAGHPTRNPEDYFAGGAILPAGGHKGFGLALLGE 255

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
           ++   L                   + + IA+  ++  + P   A  + ++D +     A
Sbjct: 256 LVGEALLG-----------PSTTECNWLLIALSAERFREAPAMAAAAEEVLDELRRCPPA 304

Query: 295 DENQAIRLPGHEFTTLLAENRRNGI-TVDDSVWAKIQAL 332
             +  + +PG       A +   GI +V    W +I+ L
Sbjct: 305 PGSSGVEIPGERERAHRAAS--GGIVSVPRDTWTQIERL 341


>UniRef50_A3N2M1 2,3-diketo-L-gulonate reductase n=2 Tax=Actinobacillus
           pleuropneumoniae RepID=A3N2M1_ACTP2
          Length = 235

 Score =  251 bits (641), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 178/235 (75%), Positives = 210/235 (89%)

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           +ELA+ +GIG+VALRNANHWMRGGSYGWQAAEKGYIGICWTN++AVMPPWGAKE RIGTN
Sbjct: 1   MELASQNGIGVVALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKEYRIGTN 60

Query: 158 PLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR 217
           PLIVA+P+TPITMVDMS SM+SYGMLEV+RLAGRQ  VD GFDD+GN T++P  +EKNRR
Sbjct: 61  PLIVAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDDGNPTRDPATVEKNRR 120

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTR 277
           ++PMG+WKGSG+SIVLDMIATLLS+G S A VT+D  DEY +SQ+FIAIEVD+LIDG T+
Sbjct: 121 LMPMGFWKGSGLSIVLDMIATLLSNGESTATVTEDKDDEYCVSQVFIAIEVDRLIDGKTK 180

Query: 278 DAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
           D KL RIMDYV +AERAD   A+RLPGHEFT +LA+N+ NGI VDD+VWAK+Q+L
Sbjct: 181 DEKLNRIMDYVRTAERADPEVAVRLPGHEFTQILADNKANGIPVDDTVWAKLQSL 235


>UniRef50_C0XQZ5 Malate dehydrogenase n=1 Tax=Corynebacterium lipophiloflavum DSM
           44291 RepID=C0XQZ5_9CORY
          Length = 312

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 72/329 (21%), Positives = 135/329 (41%), Gaps = 18/329 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  + ++  F   L + G+  E A++ A +F     +G  SHG      ++  L+N  
Sbjct: 1   MKLGIDTVRTTFFDALRAHGMSEEQAESSAGVFLDAELAGKPSHGAFHLLTYLSALDNRS 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I   A P   T+ G++   DA   +     +K  D+ +++A  +G+ + A+R        
Sbjct: 61  INGQANPTA-TARGSVLAIDADDGLAQFALEKHRDQLLDIARTNGVAVAAVRKTFTTGEL 119

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           G Y    A  G I +  TNS A++    + E  +GTNP+   IP     +VD + +  ++
Sbjct: 120 GWYARFFARHGLISLTTTNSPALVTLNASGERVVGTNPVTFGIP--EAMVVDQAATPAAF 177

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             +  +   G  LP     D  G  T +  V      +LP G  +G  +++V +M+  +L
Sbjct: 178 MRVRQHAERGEPLPQGWAVDAAGRPTDDASVAVDEGALLPNGGHRGGNLALVFEML-AML 236

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           +   S         +   +    + I+ D    G     +LQ  +  +       +   +
Sbjct: 237 AGRESSKSAANRGDEPPRVGLFALVIDPDFFGAGT--LGRLQAHLATL------ADEHEV 288

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +PG              + +DD+ W K+
Sbjct: 289 YIPGRTRPAPAE------LDIDDATWEKL 311


>UniRef50_A9I3U5 Putative malate/L-lactate dehydrogenase n=1 Tax=Bordetella petrii
           DSM 12804 RepID=A9I3U5_BORPD
          Length = 351

 Score =  247 bits (630), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 70/337 (20%), Positives = 139/337 (41%), Gaps = 16/337 (4%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
              E L       L++  VD+  A   A         G  +HG+   PR+++++  G   
Sbjct: 6   YAEEALVQFAQHCLLAVDVDAPIAAVVARRVVDADLYGHATHGLALLPRYLKEISEGATQ 65

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
              + +RI+  GA   WDA    G+    + +  A++     G+  +A+R++ H      
Sbjct: 66  RRGEIRRISEKGACLLWDAAMLPGHWVLHQAIQAALQRVPAQGMVSIAVRHSQHIGALQV 125

Query: 123 YGWQAAEKGYIGICWTNSIAV--MPPWGAKECRIGTNPLIVAIPSTP-ITMVDMSMSMFS 179
           Y     + GY+ + W     V  + P+G  +  + + P+   IP+     ++D + S+ S
Sbjct: 126 YLPDLTDAGYLCLLWATDTKVRSVAPFGGLDPVLTSEPIAAGIPTRGTPILIDTTTSLTS 185

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVI--EKNRRILPMG----YWKGSGMSIVL 233
              ++  +  G +LP       +G +T +PG +  +    ILP+G     +KG  M++++
Sbjct: 186 NSFVKQVQARGERLPWPALLSADGRVTDDPGALATDPPGTILPLGGMDHGYKGYAMAMLV 245

Query: 234 DMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER 293
             ++  LS            S E     +   I+ D          ++Q + D   +A  
Sbjct: 246 GAMSLGLSGLG-------RLSGEKAQGFLLQVIDPDAFAGRDIFLDEMQALADATRAARP 298

Query: 294 ADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQ 330
            D  + +R+PG          RR+G+ +   + A ++
Sbjct: 299 IDPARPVRVPGDAALARAERQRRHGVRLGADISAALE 335


>UniRef50_C6B4N9 Malate/L-lactate dehydrogenase n=2 Tax=Rhizobium leguminosarum
           RepID=C6B4N9_RHILS
          Length = 334

 Score =  247 bits (630), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 70/337 (20%), Positives = 126/337 (37%), Gaps = 16/337 (4%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M++  ++L+       ++ G     A A  +        G    G   F  ++  L +G 
Sbjct: 6   MRMPIDELRQLALEACLACGGSPAMAKALVDATLSAACFGRTELGFPHFVDYLTSLRDGR 65

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  DA+P+    L A+ Q DA   I  L    + D  ++     GI ++  RN+      
Sbjct: 66  INGDAKPRFNHVLPALIQADADGGIAQLGFDLIYDDFVKCVKTFGISVLTQRNSYTAGEL 125

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSM 177
           G Y  + A+ G I I   N  A+M      E    TNPL   +P     P  ++D + S 
Sbjct: 126 GYYVRRLAQDGLISIAAANGPALMAAAEGGERVYCTNPLAFGVPMPEPLPPVVIDQATSA 185

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            ++  L     A   +      D+ G +T +P        +LP G +KG  ++++++M++
Sbjct: 186 TAFITLAEAAKAQLPIAHGMAIDETGAITTDPVKAML-GALLPFGGYKGGNIALIVEMLS 244

Query: 238 TLLSDGASVAEVTQ--DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
             LS  A   +                 IA+             + +  ++ + S     
Sbjct: 245 AGLSGAAWSLDAGHFLSGEHPVNAGMTVIALFPAA--ADSDFPERAKAQLERLRS----- 297

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +R+PG            + + VD  V   I+ L
Sbjct: 298 --RGVRIPGDRTMPASV-AETDRLDVDIGVLETIRRL 331


>UniRef50_B1M8T8 Malate/L-lactate dehydrogenase n=4 Tax=Rhizobiales
           RepID=B1M8T8_METRJ
          Length = 329

 Score =  246 bits (629), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 70/336 (20%), Positives = 132/336 (39%), Gaps = 14/336 (4%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
            +T  +  A     L+  G     A + A         G+  HG++R   +  Q+  G +
Sbjct: 3   NLTLSEAGALAADALVRCGTAEAAARSVARALVGAEADGLKGHGLSRVAPYAAQVRAGKV 62

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
           + DA P        +   DA            ++    LA   G+    +R ++H    G
Sbjct: 63  VGDAVPLASRPRPGLLAIDAAHGFAYPAIDLALEALPGLARQQGVAAAGIRRSHHCGAAG 122

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAI--PSTPITMVDMSMSMFS 179
               + AE+G + + + N+ A M PWG ++   GTNPL  A   P     +VD+++S  +
Sbjct: 123 RPVERLAEQGCVALLFANTPAAMAPWGGRQAVFGTNPLAFACPLPGGAPIVVDLALSKVA 182

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
              +      G  +P     D +G  T + G       ++P+G  KG+ ++++++++A  
Sbjct: 183 RANIVGAARRGEPIPEGWALDADGRPTTDAGAALD-GTMVPLGDAKGTALALMVELLAAG 241

Query: 240 LSDGASVAEVTQ---DNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
           L       E +       D  G  Q+ + ++   L        +   +   + +      
Sbjct: 242 LVGARFAGEASSFLDAAGDPPGTGQLILVLDAAALSPDAP--ERFAALAGTIAA------ 293

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
               RLPG     L       G+ V +++ A+I+AL
Sbjct: 294 QDGARLPGSRRLGLRRRAAEAGLDVAEALVAEIRAL 329


>UniRef50_Q4KAT3 Malate/L-lactate dehydrogenase family protein n=1 Tax=Pseudomonas
           fluorescens Pf-5 RepID=Q4KAT3_PSEF5
          Length = 334

 Score =  243 bits (620), Expect = 8e-63,   Method: Composition-based stats.
 Identities = 64/331 (19%), Positives = 125/331 (37%), Gaps = 10/331 (3%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           ++  + +    R  +  G   E A A AE        G+ S G      ++    +G I 
Sbjct: 10  LSLAEARDFAQRCCLQAGSSQEVAQALAEATVSAQGHGLASVGFEHLADYLHGFASGRIA 69

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A+P       A+ + DA+  I  L   +      +     GI L AL N       G 
Sbjct: 70  GLAKPLITQVAPAMIRCDARAGIAQLGFDQAFGAVCDSTRQLGISLFALHNGFTCGELGY 129

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSY 180
           Y  + A +G + + + N  A++   G ++    TNPL  A P       ++D + S  ++
Sbjct: 130 YTRRLAAEGLVALAFCNGPALLTVAGQRQPIYSTNPLAFAAPCGDGRLLLIDQASSATAF 189

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL 240
             L     AG  +P     D +G  T           +L  G  +G+ ++++++++A  +
Sbjct: 190 VNLLKAAEAGEAIPEGWAVDAQGAATLSAREAMH-GALLAFGGSRGANIALLVEVLAGGV 248

Query: 241 SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           + G    +     S         + I +   +     +A+L R M  + +         +
Sbjct: 249 AGGNWSLDAPDFRSGAQSPGSGLLVITIAPHLLDEQFEARLARQMQRLATL-------GV 301

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
             PG       A  +  GI++  +++ ++ A
Sbjct: 302 HPPGQAKQQAWARAQIEGISLPMALYQQMAA 332


>UniRef50_A4MVY7 Putative uncharacterized protein n=1 Tax=Haemophilus influenzae
           22.1-21 RepID=A4MVY7_HAEIN
          Length = 234

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 156/215 (72%), Positives = 189/215 (87%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V++++LK  F RVL+ R +  E A+ CA  F  TT++G YSHG+NRFPRFIQQLE GD
Sbjct: 1   MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I+P+A P ++ SLG+IEQWDA ++IGNLTAKKMMDRAIELA+ HG+G++ALRNANHWMRG
Sbjct: 61  IVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRG 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY 180
           GSYGWQAAEKGYIGICWTN++AVMPPWGAKECRIGTNPLI+A+P+TPITMVDMS SM+SY
Sbjct: 121 GSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSY 180

Query: 181 GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           GMLEV+RLAGRQ  VD GFDDEGNLT++P ++EK 
Sbjct: 181 GMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKT 215


>UniRef50_B9Z109 Malate/L-lactate dehydrogenase n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z109_9NEIS
          Length = 346

 Score =  236 bits (604), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 9/263 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK+  +QL+     VL + G   + A   +         G  SHG+   P ++  + N  
Sbjct: 1   MKLAAKQLEHVSRLVLKALGCKEKEAVIVSRHLVEANLRGHPSHGIGMLPFYVASVRNKT 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           + P+   + +   GAI Q+  +R  G   A++ +D AI    + G+ L+ +RNA+H  R 
Sbjct: 61  LRPNQAARLVRDAGAILQFSGERGFGQRVAREAVDAAIWRVRETGVALLTVRNAHHMGRI 120

Query: 121 GSYGWQAAEKGYIGICWTNS----IAVMPPWGAKECRIGTNPLIVAIPS---TPITMVDM 173
           G YG Q A  G +G+ + N       ++ P+G    R G NP+ +A P     P  ++D 
Sbjct: 121 GCYGEQLANAGLVGLFFVNVTDVHTPMVSPFGGTAGRFGGNPICIAFPGTDKHPAFILDF 180

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSI 231
           + S  SYG   V  LAG++       +  G+ + +P V+ +     + PM + KG G+  
Sbjct: 181 ATSRVSYGKTRVAYLAGQRFEEPVLQNHAGHPSHDPRVMWEEPQGTLRPMAHHKGGGLLA 240

Query: 232 VLDMIATLLSDGASVAEVTQDNS 254
             + +A LLS G +         
Sbjct: 241 ATEFLAGLLSGGGTSQPGAAAPG 263


>UniRef50_B1ZP47 Malate/L-lactate dehydrogenase n=4 Tax=Verrucomicrobia
           RepID=B1ZP47_OPITP
          Length = 364

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 79/344 (22%), Positives = 142/344 (41%), Gaps = 18/344 (5%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQL---ENG 59
           V   Q  A        RG   + A A A   A  T  G+ +H   +    +  L     G
Sbjct: 7   VPEAQHNALVEAAYKKRGYSGQEAAAGARFCAEATRHGIRTHNALKALH-LDHLFGSGAG 65

Query: 60  DIIPDAQPKRITSL-GAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWM 118
              P A+ +++ +     + W+A R +G  T    ++ A++LA  +G+G+V++ NA H++
Sbjct: 66  GCKPKAKIEKVKTRFRGAQVWNANRKLGQATGYAAIETAMKLADKYGVGMVSVDNAFHYL 125

Query: 119 RGGSYGWQAAEKGYIGIC-WTNSIAVMPPWGAKECRIGTNPLIVAIPSTP----ITMVDM 173
            GG Y  +AA +GYI     T ++A + P+G K   +GTNP     P+T       ++D 
Sbjct: 126 WGGGYVMEAARRGYIAYTNCTAALAEVVPFGGKYPTLGTNPHSWGFPTTGAIGYPIVIDW 185

Query: 174 SMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVL 233
           + S+ + G ++     G+QLP     D+ G  T +P      + +LP G  KG G+S++ 
Sbjct: 186 ATSVVAMGRVQQLLREGKQLPPGAAVDENGTPTTDPAKA---KYLLPFGAHKGYGLSLMN 242

Query: 234 DMIATLLSDGASVAEVT---QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR-IMDYVT 289
           +++   +                 ++      F     D +  G     + Q   +  V 
Sbjct: 243 EIVGAFIGGSLPTLRNRWSQVTEGEKGTCCFFFQVWHPDAMNGGAFAQGRDQTGNVKAVI 302

Query: 290 SAERADENQAIRLPGHEFTTLLAENRRN-GITVDDSVWAKIQAL 332
                  N+   LPG       A + +N G+   ++       +
Sbjct: 303 GDILGHGNEGCMLPGQIEAEAAARSAKNGGLLFSEAEINAFNEI 346


>UniRef50_UPI0001AF065C L-sulfolactate dehydrogenase / malate dehydrogenase (NAD) n=1
           Tax=Streptomyces ghanaensis ATCC 14672
           RepID=UPI0001AF065C
          Length = 319

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 78/322 (24%), Positives = 134/322 (41%), Gaps = 14/322 (4%)

Query: 12  FNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT 71
                   GV  +  D   E +      G  SHG+ +F  F  Q  +  + P   P+   
Sbjct: 1   MTTACTRAGVPGKGTDRVVEHYLDGELRGKPSHGLAKF-AFESQFFSQRVGP---PRIKH 56

Query: 72  SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKG 131
             GA+   D +R +G L+A   +  A   A   G+G+V + N   +    S+  Q AE+G
Sbjct: 57  ERGAMAVVDGRREVGPLSADFAVRLAARKARRLGVGVVGMVNCQRYGILASWSEQIAERG 116

Query: 132 YIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITM-VDMSMSMFSYGMLEVNRLAG 190
            +G+    S       GA+   +G NP+  A P++  T+  DMS ++   G+L   R +G
Sbjct: 117 LVGLVANTSRPEATVHGARTPFLGVNPVSFAFPTSDSTVSADMSTTLAPMGVLWEARRSG 176

Query: 191 RQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVT 250
             LP D   D+ G  T +P         +  G  +G  +S+++ ++   L        V 
Sbjct: 177 SPLPPDCFVDEHGAFTDDPDAAR---AAMVFGEHRGFALSLLIQILTGSLFGFPMGERV- 232

Query: 251 QDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTL 310
                 +     FIA++      G         + D V  A   +    +R+PG E    
Sbjct: 233 ---DSTWTTGYTFIALDPTFAGQGEEHLVANASLTDAVRQAATREGGS-VRVPGQEGKDR 288

Query: 311 LAENRRNG-ITVDDSVWAKIQA 331
            A  R+ G +T+D++++ ++QA
Sbjct: 289 AARARKTGRLTLDEALYKRLQA 310


>UniRef50_B9BUQ2 Malate/L-lactate dehydrogenase family protein n=2 Tax=Burkholderia
           multivorans RepID=B9BUQ2_9BURK
          Length = 323

 Score =  229 bits (585), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 67/335 (20%), Positives = 130/335 (38%), Gaps = 21/335 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK   E         +   G     A + A+       +G  + G    P ++     G 
Sbjct: 1   MKYEQEAAWRVAFDAIRRAGASEAVAHSLADAVISAELAGSKAVGFAHLPDYLDGFVIGR 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  DA+P       A  + DA+  I  L   ++ D  +  +  +G+  +A+ N+      
Sbjct: 61  IAADAEPDVSFPALAAIRADARGGIAQLAYDRVFDELVGRSNTYGVVTLAVSNSFTVGEL 120

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMF 178
           G Y  + AE+G + +   N+ A M    + +   GTNP+  A P  +    ++D + S  
Sbjct: 121 GYYTRRLAERGLVALGTCNATAQMTTLESGKAVYGTNPVSFAAPVANARPFVIDQASSAT 180

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIAT 238
           ++  +     AG  +P     D+ G  T +      N  +LP G  +G+ ++++++++A 
Sbjct: 181 AFVSVRKAAEAGEAIPEGWAVDEHGRPTTDARAAI-NGLLLPFGGARGANLAMMMEILAA 239

Query: 239 LLSDGASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADE 296
            ++ G     A      S+  G+    +A++ D            Q  +D ++ A     
Sbjct: 240 GVTGGNWSMDAPHYAKGSESPGVGLFVVAVKADVFAADFAARLAAQ--IDRLSKA----- 292

Query: 297 NQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
              +R+PG              I V D V   +++
Sbjct: 293 --GVRIPGSHIKVRE-------IDVADDVMNNVRS 318


>UniRef50_A8I4Z4 Malate dehydrogenase n=6 Tax=Alphaproteobacteria RepID=A8I4Z4_AZOC5
          Length = 376

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 83/337 (24%), Positives = 143/337 (42%), Gaps = 7/337 (2%)

Query: 2   KVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDI 61
           +     L A     L + G D+ T DA        +  GV SHGV     ++  LE G +
Sbjct: 25  RYREADLSAFCEAALRAAGADAPTVDAATRAMMHASRLGVDSHGVRLLNHYVSALEGGRV 84

Query: 62  IPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGG 121
                   +   GA+   DA  + G L A   MDRA++LA+  GIG VA+RN++H+   G
Sbjct: 85  ARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAG 144

Query: 122 SYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFS 179
           ++   AAE+G++G+ + NS + +      E   GTNP+  A P       + DM+ S   
Sbjct: 145 AFALAAAERGFVGLAFCNSDSFVRLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVP 204

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +  + + R     LP D   D EG  T++   ++    +     +KG+G++ ++++ + L
Sbjct: 205 FNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDMLAPLGGAFGFKGAGLAGLVEIFSAL 264

Query: 240 LSDGASVAE----VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERAD 295
           LS      +    V  D +    I    +A+     ++    +  + R +  +  +    
Sbjct: 265 LSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAFLEPEVYEEGMARYLRTLRRSRPTA 324

Query: 296 ENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
             + +  PG           R GI VD +       L
Sbjct: 325 GGE-VLAPGDREWREADNRARMGIPVDPATAEAFAQL 360


>UniRef50_B6A0G2 Malate/L-lactate dehydrogenase n=3 Tax=Rhizobium RepID=B6A0G2_RHILW
          Length = 333

 Score =  226 bits (578), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 55/307 (17%), Positives = 106/307 (34%), Gaps = 9/307 (2%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +   + +A   R  ++ G    TA +  +        G    G      ++     G I 
Sbjct: 7   LDQTEAEALAMRACLAVGAGEATARSLVDATLSAAIYGPAMLGFPHMVDYLDSFREGRIN 66

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
            +  P+      A    DA R I  L      D  +    + G+ +    N+      G 
Sbjct: 67  CNPAPRCERPYPAFFVADADRGIAQLGFDLAFDDLLAAVRNFGLAVFTQTNSYTAGELGY 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTP---ITMVDMSMSMFS 179
           Y  + A +G +GI  TN+ A++           TNP+    P        ++D + S  +
Sbjct: 127 YVRRLAGQGIVGIAATNANAMVVAKAGGPAVYSTNPMAFGFPLGEGSLPLIIDQASSATA 186

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           Y  +       R +P     D+ G  T++         +LP G  KG+ ++++++M++  
Sbjct: 187 YVNIVAAAAERRAIPEGWAVDEAGKDTQDAARAL-GGALLPFGGRKGANVALMVEMLSAG 245

Query: 240 LSDGASV--AEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAER-ADE 296
           LS G         ++ S    +    +A+   +         + +R  D +         
Sbjct: 246 LSGGPWSLDTPSFREGSVSPAVGLTVVAMMPGR--SDDGLVERARRQTDRLQEKGVFVPG 303

Query: 297 NQAIRLP 303
              I  P
Sbjct: 304 VSGIEYP 310


>UniRef50_UPI0001BC2BBF malate dehydrogenase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2BBF
          Length = 329

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 74/324 (22%), Positives = 124/324 (38%), Gaps = 12/324 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           + +   +L+      ++  G   + A + A              G      ++  LE G 
Sbjct: 10  VSLPATELERLCTSAILDAGGSEKLAASLAAATVAADRRDKIQVGTAHLFDYLDGLEAGR 69

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I   A P+ +  L A    DA   I  L   ++ DR  + A D GI ++ + NA      
Sbjct: 70  INGAAVPRSVNRLPAAHLVDADGGIVQLAFDEVFDRFAQSATDLGISILNIMNAFPAGEL 129

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TPITMVDMSMSMFS 179
           G Y  + A +G I +   NS A+M  +G+++   GTNPL  A+P      M D + S  +
Sbjct: 130 GYYTMRLARRGLIALAGGNSPALMSLFGSRDTVTGTNPLSFALPHPQGPRMFDQASSATA 189

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATL 239
           +  +      G  +P       +G  T +P        +LP G  KGS ++++++++A  
Sbjct: 190 WVNIRDAADRGESIPEGWSQAPDGTATTDPEAGL-AGSLLPFGGVKGSNLALMIELLAAH 248

Query: 240 LSDGASVAEVT--QDNSDEYGISQIFIAIEVDKLID-----GPTRDAKLQRIMDYVTSAE 292
                   +     + +   G     IAI  D              A+L R  ++     
Sbjct: 249 -GGANFSVDAPPIDEGTTTPGTGLFVIAISADAFDPEYTLRVEEHLARLDR--EFGIDFG 305

Query: 293 RADENQAIRLPGHEFTTLLAENRR 316
           R   +  I LPG   T LL    R
Sbjct: 306 RKRNDTVINLPGDLHTALLERAAR 329


>UniRef50_A6UJP8 Malate/L-lactate dehydrogenase n=2 Tax=Sinorhizobium
           RepID=A6UJP8_SINMW
          Length = 331

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 84/338 (24%), Positives = 147/338 (43%), Gaps = 23/338 (6%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           ++++ E+++A     L   G  +  A   A   A    +G    G+   P F + L  G 
Sbjct: 4   VELSREEIEAVCLAALTVHGAAAGNARPVARAIAMAEAAGNRVCGLYYLPIFCRHLAIGK 63

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           +   A P+  ++ G     DA+    +          I+LA  +G+G +A+RN+ + +  
Sbjct: 64  VDGGAIPEV-SARGVTVTVDARSGFAHPAIAAGTPALIDLARSNGLGAMAVRNSYNCLAL 122

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
           G +    A+ G IGIC +N+ A + P GA     GTNPL  A+P    TP  +VD S+S 
Sbjct: 123 GHHVHPLADAGLIGICVSNAPAAVAPPGAAAALFGTNPLAFAVPSKEGTPAILVDQSLSA 182

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIA 237
            +   + + R  G  +P     D  G  T +  +  +   +LP G  KG+ ++++++++A
Sbjct: 183 VTKTEMILRRDRGEAIPAGWAQDRNGQPTTDAAIGLE-GSLLPAGGRKGANVALLVEVLA 241

Query: 238 TLLSDGASVAE---VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             L+      E      D      + Q  IAI+      G        R  + + +   +
Sbjct: 242 AALTGSVLSTEASAFGNDEGGPPHVGQFLIAIDPGHFSAG--------RFSEAIDNLVAS 293

Query: 295 DENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            E   +RLPGH         R+  + VD  +W K++ L
Sbjct: 294 HEAAGVRLPGHSG-------RKQAVFVDADLWKKVRLL 324


>UniRef50_C3MEC9 Malate dehydrogenase n=3 Tax=Rhizobium RepID=C3MEC9_RHISN
          Length = 381

 Score =  223 bits (568), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 66/329 (20%), Positives = 124/329 (37%), Gaps = 20/329 (6%)

Query: 6   EQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDA 65
           ++ +    R     G    T  +           G  + G      ++    +G I  + 
Sbjct: 52  QEAEGLAARACRGAGATEPTTRSLVAATMSAALFGPPTLGFPHLVDYLDSFRDGRISTNP 111

Query: 66  QPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGW 125
           QPK      A    DA R I  L   +  D+ +E     G+ +    N+      G +  
Sbjct: 112 QPKLNRPFAAFFVSDADRGIAQLGFDQAFDQFVETVRHFGVAIFTQTNSYTAGELGYFVR 171

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSMFSYGM 182
           + A +G +G+  TN+ A++           TNPL    P    +P  ++D + S  ++  
Sbjct: 172 RLAAEGIVGLAATNANAMVVAKPGGPAVYSTNPLAFGFPMGDGSPPMIIDQASSATAFVN 231

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSD 242
           +      GR +P     D +GN T++P +  K   +L  G  KG+ ++++++M++  LS 
Sbjct: 232 IVAAASEGRSIPAGWAVDADGNDTEDPNLALK-GALLAFGGRKGANVALMVEMMSAGLSG 290

Query: 243 GASVAEVTQDNSD--EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI 300
           G    +     S     G+    IA+      D   R A+ +   D +           +
Sbjct: 291 GPWSLDTPDFRSGDVSPGVGMTVIAMMPGV--DQAARIARARTQADRLAGL-------GV 341

Query: 301 RLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            +PG   T+   +     +T+   V  +I
Sbjct: 342 FIPGVTGTSKKEQ-----LTIPAGVHRRI 365


>UniRef50_B7RZN2 Malate/L-lactate dehydrogenase subfamily protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RZN2_9GAMM
          Length = 375

 Score =  218 bits (556), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 69/344 (20%), Positives = 126/344 (36%), Gaps = 24/344 (6%)

Query: 5   FEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPD 64
            E L  + ++V  + G+  E A   A+        G  + G+  +      LE G + P 
Sbjct: 10  PEFLHFSLSQVAQAAGMSEEHAGYIADAIVFAHRQGKLNQGLGVYEAIDLVLEIGVLDPL 69

Query: 65  AQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYG 124
           A P+ +    A   +D + S G  T   M   AIE A ++GI +    N N      SY 
Sbjct: 70  AVPEMVDEGPAFAVFDGKGSSGYYTLTLMAKAAIEKAREYGIAIAFGGNHNDGGSFASYV 129

Query: 125 WQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY--GM 182
             A E+G +GI   N++ +  P+GA E  +   P    IPS     +  S+    +    
Sbjct: 130 HMAYEQGMVGIASNNTVPLAAPFGAMENMLSCPPFDAIIPSGKEPPIWASLKFAEWYDAD 189

Query: 183 LEVNRLAGRQLPVDGGFDDE-GNLTKEPGVI------------------EKNRRILPMGY 223
           +    L  + +      D E G LT                         +  R   +  
Sbjct: 190 ISEAVLQDKPMKGKWLIDPESGELTDNAKPYAKPIPGYGRVWDATCAGQIETPRTYALNL 249

Query: 224 WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQR 283
           W   GM  +++ +    ++  ++ +    N+        F+ I+  +         +  +
Sbjct: 250 WN-EGMCSIINPLGKPSTELPTIEDFAAGNAAPSVGGSYFMCIDPSRFGPLAAVQERSDK 308

Query: 284 IMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
            ++ V +A+       +R+PG      L +N    + V ++ WA
Sbjct: 309 FINKVRNAKPRPG-HRVRIPGESGYRSLTQNEPT-VEVLENHWA 350


>UniRef50_B8KS33 Putative uncharacterized protein n=1 Tax=gamma proteobacterium
           NOR51-B RepID=B8KS33_9GAMM
          Length = 354

 Score =  215 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 60/312 (19%), Positives = 114/312 (36%), Gaps = 17/312 (5%)

Query: 7   QLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQ 66
            L      +L + G     A   A     +   G  +HG++  P ++Q  E G I   A 
Sbjct: 8   TLAKLATDILEAIGTPPTPAAQVAHSLLESDRRGAPTHGLSLLPLYVQMAEAGVIDATAT 67

Query: 67  PKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQ 126
           P       ++ + D + + G LT  + ++  I+ A   G+  + + +  H  R G +  +
Sbjct: 68  PVTHDLGASLARVDGRAAFGQLTGSEAVNVGIQKAQQQGVAAIGIGDGTHLGRLGEWAER 127

Query: 127 AAEKGYIGICWTNSIA---VMPPWGAKECRIGTNPLIVAIP----STPITMVDMSMSMFS 179
           A +     + + N+      +         +  NP+   IP    +    +VD + S  S
Sbjct: 128 ACDADIAFLAFGNTGGGALTVAGPNKASRVLAPNPIAFGIPTCGATENHVIVDFATSQVS 187

Query: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMG----YWKGSGMSIVLD 234
              +     AG +L  D     +G +T +P         + P+G      KG G+ +  +
Sbjct: 188 GSRIREAANAGDRLNPDWVIAADGGITDDPQAFLDGLAALRPLGGASAGHKGFGLMVAAE 247

Query: 235 MIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA-ER 293
           M A+ ++ G    E        +    +F+ ++V +         +      YV S   R
Sbjct: 248 MFAS-MAGGLMAGEEEVPW---FTNGALFLLLDVTRFAPREAWAGRAGAFTRYVESCGYR 303

Query: 294 ADENQAIRLPGH 305
              +   R PG 
Sbjct: 304 MPGSGGTRGPGD 315


>UniRef50_Q5DB34 SJCHGC06758 protein n=2 Tax=Bilateria RepID=Q5DB34_SCHJA
          Length = 232

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 46/219 (21%), Positives = 105/219 (47%), Gaps = 14/219 (6%)

Query: 126 QAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST---PITMVDMSMSMFSYGM 182
            A ++G IG+ +TN+  ++ P  A++  +GTNPL +A P        ++DM+ S  + G 
Sbjct: 1   MALQEGLIGLAFTNTSPLVFPTRARKLAVGTNPLTLAAPGKVPDDHFVLDMATSAVALGK 60

Query: 183 LEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMG------YWKGSGMSIVLDMI 236
           +E+NR  G ++P+  G D +G    +P ++     ++P+G       +KG G+ ++++++
Sbjct: 61  IEMNRRRGLEIPIGWGADQDGKTCVDPNLVVTKGGLMPLGGEEEHSGYKGYGLGMLVEIL 120

Query: 237 ATLLSDGASVAEVTQDN--SDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERA 294
             ++++      V +      +  + Q F+AI+      G   + +L   ++ + +    
Sbjct: 121 CGIIANADFGPNVRRWMTTEKQANLGQSFLAIDPKAFAPG--FEQRLSEYVNIMRNLPPV 178

Query: 295 DENQAIRLPGHEFTTLLAENRR-NGITVDDSVWAKIQAL 332
           ++ + + +PG      + E  +  GI     +   +  L
Sbjct: 179 NDKEPVVVPGDFEREHMIECDQLGGIPYPPVLLESLNRL 217


>UniRef50_UPI0000E470A0 PREDICTED: hypothetical protein, partial n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E470A0
          Length = 246

 Score =  200 bits (509), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 53/251 (21%), Positives = 106/251 (42%), Gaps = 24/251 (9%)

Query: 64  DAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSY 123
           D++P  +         D Q  +G +     + +AIE AA +GIG V +         G +
Sbjct: 5   DSEPVVLHETVGSAWLDGQGCLGAVVGSFAIKKAIEKAAQNGIGWVLI-------ILGLW 57

Query: 124 GWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPS--TPITMVDMSMSMFSYG 181
                +    G+C +N+       G+K+  +GTNP+ +A         + D ++++ +  
Sbjct: 58  NGFLCKHVNRGLCMSNTWPASVVPGSKQRVLGTNPICLAAAGLDGDYLLFDSALTVTAMR 117

Query: 182 MLEVNRLAGR-QLPVDGGFDDEGNLTKEPGVIEKNRRILPM-------GYWKGSGMSIVL 233
            ++    +G   +P   G D  G  T +   I  N  +LP+       G  KG G+ +++
Sbjct: 118 KVKEKTKSGDGSVPEGWGVDQNGQPTTDGASILNNGALLPLGGISPLTGGHKGFGLILLV 177

Query: 234 DMIATLLSDGASVAEVTQDNSD-----EYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYV 288
           +++ ++L+  A  +++ + + +          Q FIAI+      G     +LQ ++DY 
Sbjct: 178 EVLTSVLAGSAFSSDIGKKDGESGAFVGKDFGQTFIAIDPSHFGGG--FSDRLQFLLDYC 235

Query: 289 TSAERADENQA 299
              E     + 
Sbjct: 236 RHLEPGSLGEQ 246


>UniRef50_UPI0000D54A60 putative malate/L-lactate dehydrogenase n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D54A60
          Length = 234

 Score =  191 bits (487), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 38/230 (16%), Positives = 94/230 (40%), Gaps = 13/230 (5%)

Query: 111 LRNANHWMRGGSYGWQAAEKGYIGI--CWTNSIAVMPPWGAKECRIGTNPLIVAIPS-TP 167
           ++N++H     +Y      KG + +  C   S A + P+G  +  +  +P+ +A P+   
Sbjct: 2   IKNSHHNGALAAYLLPVVAKGLVPMIKCSVPSAATVAPFGGTKALLTPDPMALAFPTNGE 61

Query: 168 ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN-RRILPMGY--- 223
             ++D+S S+ +  M+    +       +     +G  T +P  + +N   ++P+G    
Sbjct: 62  PVIIDISASITTNNMIADKIVKNEMFDFNCLLTKDGIPTNDPKEVFENNGTVMPLGGLEY 121

Query: 224 -WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQ 282
             KG G+++ ++ ++  LS      ++         +S     I+ +          ++ 
Sbjct: 122 GHKGFGLALGIEALSQGLSGSGRSRKL-----KTMNLSIYIQVIDPNAFAGIDAFKNEMS 176

Query: 283 RIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
            + +   +    D+N  +R+PG        ++  NGI +       ++ +
Sbjct: 177 FLYNECINNPPIDKNNKVRMPGQNALLSRKKSIENGIYLSKETLKSLEEI 226


>UniRef50_UPI00016955AA hypothetical protein Plarl_18817 n=1 Tax=Paenibacillus larvae
           subsp. larvae BRL-230010 RepID=UPI00016955AA
          Length = 331

 Score =  186 bits (473), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 59/336 (17%), Positives = 110/336 (32%), Gaps = 29/336 (8%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            T E L+          G+    A   +E        G+ SHG+ R     +QL      
Sbjct: 11  YTIESLRQKVQNRFEQAGLSEYQAREMSEQLLYAEMRGISSHGLVRIKWVTEQLHK---Y 67

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
           P    + +      E +DA   +G L   ++ ++  +      I  + +RN         
Sbjct: 68  PLKNVRLLLQNREAELYDADGVLGYLALNEVAEK-QQRFEGQTIKFIGIRNTYPTGALSY 126

Query: 123 YGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST----PITMVDMSMSMF 178
           +  + A KG+I +  + S   +  +G  +  +GTNP    +P         +VD+S+S  
Sbjct: 127 FSEKLAAKGWIVLMSSTSPRRVGLYGDDKGLVGTNPWTFTLPVETNYSGQVVVDVSLSEI 186

Query: 179 SYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRR----ILPMGYWKG---SGMSI 231
           ++G       AG+ LP        G     P  + K       + P+G  KG    G+  
Sbjct: 187 THGQCLKAVEAGQPLPNYAASQPGGLAINHPDDLWKEGNWNAILHPVGRDKGFKPFGVMW 246

Query: 232 VLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSA 291
            L ++ + +                       + +              ++   + V   
Sbjct: 247 SLHVMGSRMLG----------LDGVESHGTFILLLSPSMWEPIIPAYEVIKGFNEEVKLL 296

Query: 292 ERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWA 327
             +       +PG    + L E +   ITV   +  
Sbjct: 297 SMSKVAH---VPGEGRMSRLKEQKDQ-ITVTQEIVN 328


>UniRef50_A6D9E5 Putative uncharacterized protein n=1 Tax=Vibrio shilonii AK1
           RepID=A6D9E5_9VIBR
          Length = 391

 Score =  185 bits (471), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 45/324 (13%), Positives = 96/324 (29%), Gaps = 28/324 (8%)

Query: 12  FNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRIT 71
            +      G D   AD  A         G    G+          E G + P + P+  +
Sbjct: 20  VSESWKHIGADQTHADILAHNLLVGGLQGKLHQGLGVIEAVTIPYEAGILDPTSTPELES 79

Query: 72  SLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKG 131
                  ++ ++S G+     M   AIE A  HGI +V   +        +Y   A ++G
Sbjct: 80  EGDTWAVYNGKKSSGHYVCTLMAQTAIEKARKHGISIVFGYDHCDGGNFSNYTQMAMKEG 139

Query: 132 YIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGM-----LEVN 186
              +   NS+ +  P+G  +  +   P   A+       +   ++    G      +   
Sbjct: 140 MFAMSSNNSVPLNAPFGGMDPAMSCPPFDAALVGGEELPL---VTSIMIGEGYDSHICDA 196

Query: 187 RLAGRQLPVDGGFDDE-GNLTKEPGV----------IEKNRRILPMGYWKGSGMSIVLDM 235
            +  R L V    D + G LT +             +   +        +   ++I  ++
Sbjct: 197 IVNDRDLHVAALVDQDTGELTADARKWGSLIEGYGRVADCKAPWTFLTPRLYSLNIWNEV 256

Query: 236 IATLLSDGASVAE---------VTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMD 286
           +  +++    +A           T +++         + I+            K    + 
Sbjct: 257 MTAIINPKGKIAPELPAVPSDFFTMEDAPCPVGGSYILVIDPSHFGPIEEVKRKSDMFVK 316

Query: 287 YVTSAERADENQAIRLPGHEFTTL 310
            +           + +P       
Sbjct: 317 AIKENRPRAGFNEVYIPDEWGLKA 340


>UniRef50_Q2JYL8 Putative malate dehydrogenase protein n=1 Tax=Rhizobium etli CFN 42
           RepID=Q2JYL8_RHIEC
          Length = 235

 Score =  179 bits (456), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 43/217 (19%), Positives = 76/217 (35%), Gaps = 3/217 (1%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           +     + ++   R   + G    TA +  +        G  + G   F  ++     G 
Sbjct: 5   VLFDLAEAESLAMRACRAAGASEATARSLVDATLSAALYGPPAVGFPHFVDYLDSFREGR 64

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
           I  D  P       A    DA R I  L  +      +E     G+ +    N+      
Sbjct: 65  INRDPAPTCERPYPAFFAADADRGIAQLGFELAFKDLVEAVRTLGVAVFTQTNSYTTGEL 124

Query: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIP---STPITMVDMSMSM 177
           G Y  + A +G +GI  TN+ A++           TNP+    P    +P  ++D + S 
Sbjct: 125 GYYVRRLAGEGIVGIAATNANAMVVAKAGGPAVYSTNPMAFGFPLGDGSPPLLIDQASSA 184

Query: 178 FSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEK 214
            +Y  +      GR +P     D+ G  T++     +
Sbjct: 185 TAYVNVAAAAAEGRSIPEGWAVDEAGQETQDAARAAE 221


>UniRef50_C8VKP5 Putative uncharacterized protein n=2 Tax=Emericella nidulans
           RepID=C8VKP5_EMENI
          Length = 230

 Score =  171 bits (435), Expect = 3e-41,   Method: Composition-based stats.
 Identities = 52/242 (21%), Positives = 98/242 (40%), Gaps = 35/242 (14%)

Query: 94  MDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECR 153
           M  AI+ A  +GIG+V++ ++NH+    +Y  QA +   I + +T+S   MPP+G KE  
Sbjct: 1   MAEAIKRAEIYGIGMVSVNHSNHFGMAATYVLQALQANMISLVFTSSAKQMPPFGGKETP 60

Query: 154 IGTNPLIVAIPSTP--ITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGV 211
           +G  P     PS      ++D++ S                           +  ++ G 
Sbjct: 61  LGIAPFAAGAPSNREVPYILDIAPST------------------------PMSPQRKYGS 96

Query: 212 IEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQD--NSDEYGISQIFIAIEVD 269
             + + +       GSG++I++D+++++L+      +V     ++        FIAI+ D
Sbjct: 97  DRRTKGL-------GSGIAILMDIMSSVLTVAGFGGQVGDRYKDAKPQDAGHCFIAIKPD 149

Query: 270 KLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
                    A++  ++  V     A     +  PG     L  + RR GI   D+     
Sbjct: 150 VCFSVDDLKARMDTLVQRVHGVIPAPGFSEVLFPGEPEQRLCLQRRREGIPYADAERKMF 209

Query: 330 QA 331
             
Sbjct: 210 TE 211


>UniRef50_UPI000169989B dehydrogenase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2'
           RepID=UPI000169989B
          Length = 167

 Score =  155 bits (392), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 41/172 (23%), Positives = 80/172 (46%), Gaps = 7/172 (4%)

Query: 85  IGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVM 144
           +G + A    D AI+LA+ +G+G+V + ++N     G Y  + A+ G + + W NS   +
Sbjct: 1   MGQVAA----DTAIDLASKNGVGVVTVSDSNFLGSLGYYVDKIAKNGMLAVLWNNSFPKV 56

Query: 145 PPWGAKECRIGTNPLIVAIPSTPI--TMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDE 202
            P+G  +  +GTNPL  A P       + D+S    +   +      G+ +P       +
Sbjct: 57  APYGGVKAVLGTNPLAFAAPRRNGRNVIADLSTGASAGSTITKAAELGQPIPEGIAIARD 116

Query: 203 GNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNS 254
           G    +P  + K+  +LP G  KG  + ++++++A +++       V     
Sbjct: 117 GTPITDPAKV-KDGALLPFGGAKGYALGLMVEIMAGVVTGAGISHGVHSMYG 167


>UniRef50_C1ZI52 Malate/lactate dehydrogenase n=1 Tax=Planctomyces limnophilus DSM
           3776 RepID=C1ZI52_PLALI
          Length = 351

 Score =  131 bits (330), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 47/297 (15%), Positives = 105/297 (35%), Gaps = 17/297 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTE--SGVYSHGVNR--FPRFIQQL 56
           + +    L+ +  +VL  +G+    +    +          G    G++       ++ +
Sbjct: 22  VSLQVADLQQSILKVLTRQGLFGADSQHVIDYILSPWLPAWG----GLHLPYLSSMVRAM 77

Query: 57  ENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANH 116
           + G+I P  +   +    ++   D  R+ G++      +  +E A   GI    +RN++ 
Sbjct: 78  DLGEIDPRGRILTVRDQPSLVHLDGSRAAGSVAMAYATELLVEKAKATGIAGAVIRNSSA 137

Query: 117 WMRGGSYGWQAAEKGYIGICWTNS-IAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSM 175
             R  +     A +G IG   +++  A   P G +  R+  +     +P+     + +S 
Sbjct: 138 IDRPEAVVANLAHRGLIGFMVSSTGRAEFSPVGDRTPRVAGHRSAWCLPAASSLTL-IST 196

Query: 176 SMFSYGMLEV---NRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIV 232
            + S   L +    +  G+    D  FD EG   +          +   G        ++
Sbjct: 197 QVASLDSLMLLDPAQTEGQP-AADLAFDKEGQPARSWNSARTFGLLT--GEHDLQ-YGLL 252

Query: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVT 289
             ++   LSDG    E  + +        + +AIE    +       +L   +  + 
Sbjct: 253 CGLLLAALSDGRLPTERAKKSPFGDDSEHLLLAIEPSSEMAERFPPERLAAFVSSMK 309


>UniRef50_C8Q676 Putative malate/lactate dehydrogenase n=1 Tax=Pantoea sp. At-9b
           RepID=C8Q676_9ENTR
          Length = 132

 Score =  111 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 26/120 (21%), Positives = 45/120 (37%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
            +   L+    + L   GV   TA   A+    ++  G  SHGV+  PR+I  +  G++ 
Sbjct: 4   FSHTWLRQYLRQHLQVAGVRPATAGEVADNLVESSLKGHDSHGVSLIPRYIAAIRAGELD 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGS 122
             A        G +  +      G +  + +M++AI  A   G  +V L           
Sbjct: 64  AQATISLTRDTGPMLSYHGNNGFGQVNGRLVMEQAILRARRFGACVVGLSTLTISGALAP 123


>UniRef50_UPI0001AF36FA ureidoglycolate dehydrogenase n=1 Tax=Salmonella enterica subsp.
           enterica serovar Tennessee str. CDC07-0191
           RepID=UPI0001AF36FA
          Length = 131

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 42/103 (40%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MK++ E L       L   G+  E A   A++       G++SHG  R   + +++  G 
Sbjct: 1   MKISRETLHQLIENKLYKAGLKREHAAIVADVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAAD 103
              +   +   +        A  + G + AK  M+ AIE+A  
Sbjct: 61  TNREPTFRIENTGPCTAILHADNAAGQVAAKMGMEHAIEIAKK 103


>UniRef50_B6QNX4 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC
           18224 RepID=B6QNX4_PENMQ
          Length = 136

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 4/119 (3%)

Query: 218 ILPMGYWKGSGMSIVLDMIATLLSDGASVAEV---TQDNSDEYGISQIFIAIEVDKLID- 273
           +LP+G  KGSG+++++D+   LL+  +   +V     +  +  G+   F+  + +  +D 
Sbjct: 1   MLPIGGAKGSGLAMMMDIFGALLTASSFAGDVNDQYNNTRNPQGVGHWFMVFKPETFLDS 60

Query: 274 GPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                 ++  ++  V   E+ +    IR+PG   T +    R  GI         +  L
Sbjct: 61  RDELADRMDTLLGRVRPCEKVEGVDRIRVPGENATEMETRRRFEGIPFTAVELKNLNLL 119


>UniRef50_UPI0001B54124 malate/L-lactate dehydrogenase n=1 Tax=Streptomyces sp. AA4
           RepID=UPI0001B54124
          Length = 187

 Score = 92.5 bits (229), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 38/237 (16%), Positives = 78/237 (32%), Gaps = 65/237 (27%)

Query: 98  IELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTN 157
           ++ A   G+GL+++R    + R G +  +A   G IGI             A +     +
Sbjct: 1   MQRAGRFGVGLLSVRGVGPFGRVGHHAARALPHGMIGIVMA------AGGYADQPV---H 51

Query: 158 PLIVAIPST--PITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKN 215
           PL +A P+   P  + D+ ++  +                            +P      
Sbjct: 52  PLGMAAPAGAYPEFVFDIDLADAAR---------------------------DPRFA--- 81

Query: 216 RRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGP 275
                       G ++++D++A +LS  A           E+    + +AI    L    
Sbjct: 82  ------------GFALMVDVLAGVLSGVA---------DHEHDTGLLVLAIAPTTLRSAD 120

Query: 276 TRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL 332
                   +   +      +    +R PG      L + R  G+ +  +V  ++ +L
Sbjct: 121 GFYRAASAVFGSMLG---WEGGAPVRYPGWREAQYLEQCRALGVPLPGAVRRQLDSL 174


>UniRef50_Q88JF9 Putative uncharacterized protein n=2 Tax=Pseudomonas putida
           RepID=Q88JF9_PSEPK
          Length = 233

 Score = 77.9 bits (191), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 23/132 (17%), Positives = 49/132 (37%), Gaps = 5/132 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M+V+  +++    +     G      +  AE+       G+   GV    + ++ L+   
Sbjct: 3   MRVSLNEIQVMCRKAFEGMGFAPGDCEDAAELVGWLQLQGLD--GVGALEKALRYLQAEA 60

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             P A         A+   DA+       A  +++ A   A   G   + +R+ ++ +  
Sbjct: 61  ARPYA---LCHEDNALLVIDAKGQSVLRCAATVVELAAAKAMRCGQAELRIRHCHNRLLL 117

Query: 121 GSYGWQAAEKGY 132
             Y  +AA +G 
Sbjct: 118 LGYLSRAAVQGL 129


>UniRef50_A4FCS6 Putative uncharacterized protein n=1 Tax=Saccharopolyspora
           erythraea NRRL 2338 RepID=A4FCS6_SACEN
          Length = 158

 Score = 77.5 bits (190), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 17/112 (15%), Positives = 41/112 (36%), Gaps = 8/112 (7%)

Query: 221 MGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAK 280
            G  KGSG+++V+  ++ +++  A+              +     ++   L +      +
Sbjct: 2   WGGHKGSGLAMVVR-LSGMMTGAAAAPP------GVSDCALFIALVDPGVLTEPADYRRR 54

Query: 281 LQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNG-ITVDDSVWAKIQA 331
           +    D + +A   +    +R+          E  R G I V ++V   +  
Sbjct: 55  IATFADSIRAARPVEGGSTVRVSFDRSVACREETLRRGTIDVPEAVVTALCR 106


>UniRef50_A4FJI4 Putative uncharacterized protein n=1 Tax=Saccharopolyspora
           erythraea NRRL 2338 RepID=A4FJI4_SACEN
          Length = 133

 Score = 76.8 bits (188), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 16/114 (14%), Positives = 37/114 (32%), Gaps = 2/114 (1%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
           +T    +A     +      ++ A+  A+        G+   G+ R    ++++      
Sbjct: 4   LTLSDARALATATMTRISHTADEAEIIADHLLDCELRGLLFGGLARALSIVERIRATPES 63

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANH 116
           P  + + +         D    +G     + ++ A       G  +V  RN  H
Sbjct: 64  P-GRIRIVAQTAVSATLDGGDKVGYFVGMRALELAWTR-HARGSAIVGARNLVH 115


>UniRef50_A3JD36 Putative uncharacterized protein n=2 Tax=Gammaproteobacteria
           RepID=A3JD36_9ALTE
          Length = 255

 Score = 75.6 bits (185), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 23/132 (17%), Positives = 44/132 (33%), Gaps = 4/132 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV+F +L+    +     G D   A   A+M       G+   G+    R +  +    
Sbjct: 1   MKVSFNELQGLSRKAFSGVGFDDGDASDAADMVVWMEAHGLN--GIQSLKRSLAFILEE- 57

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
                 P+ I     +   DA        A   ++         G+ +  +R+ ++ M  
Sbjct: 58  -DQSHSPEIIYQDADLCVVDAHNRTALNNASLAIELGYAKCRARGLSVTKIRHCHNRMLI 116

Query: 121 GSYGWQAAEKGY 132
             Y  + A +  
Sbjct: 117 VGYLSRVARRNM 128


>UniRef50_B5JCB8 Putative uncharacterized protein n=1 Tax=Octadecabacter antarcticus
           307 RepID=B5JCB8_9RHOB
          Length = 128

 Score = 75.6 bits (185), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 58/124 (46%), Gaps = 3/124 (2%)

Query: 212 IEKNRRILPMGYWKGSGMSIVLDMIATLLSDG---ASVAEVTQDNSDEYGISQIFIAIEV 268
              +  +  +G  KG+ +S+ LD+    LS G     VA+  +  S +  +S +F+ ++ 
Sbjct: 2   AALSGILQAIGGAKGANLSMCLDLFQGRLSGGVILGKVADQHKGPSRQQDLSLMFLLVDP 61

Query: 269 DKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAK 328
             L +  +    +   +  + + E AD   A+RLP     + + ++ R G+ +   + A+
Sbjct: 62  KALEEVNSSGETIADALKQIENNEPADPAAAVRLPNARAVSQIRKSERAGLRLSAPLLAQ 121

Query: 329 IQAL 332
           ++ L
Sbjct: 122 LEKL 125


>UniRef50_B7RV64 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RV64_9GAMM
          Length = 253

 Score = 74.1 bits (181), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 22/137 (16%), Positives = 41/137 (29%), Gaps = 8/137 (5%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV+  ++ A   +V           ++ A+M       G+   G+      +  L    
Sbjct: 1   MKVSKNEITALLKQVFEGLKFRCGEYESAADMIVWAEMCGLS--GLLALRHSLPYLTE-- 56

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
                  + I         DA        A  +M+ A   A       V + N ++    
Sbjct: 57  -QSPPPLRSIHESETKAVLDANNGSSLNCADVVMNLAYTKALAQECCSVTVLNCHNR--- 112

Query: 121 GSYGWQAAEKGYIGICW 137
             +    A+ G  G+  
Sbjct: 113 KLFIKTIADCGNRGMSC 129


>UniRef50_A7TC77 Predicted protein n=4 Tax=cellular organisms RepID=A7TC77_NEMVE
          Length = 509

 Score = 73.7 bits (180), Expect = 8e-12,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 43/115 (37%), Gaps = 4/115 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           M V+  +LKAA  R   + G      +  A M     + G+   G+    R +  +    
Sbjct: 261 MHVSMNELKAALRRCFEATGYFVGNYEDAANMILWLEKHGLG--GLKELERALPFIGVDR 318

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNAN 115
             P +      S  AI     + ++  + A   +D A   A + GI  V + N +
Sbjct: 319 DKPLSTVVYEDSTSAIIDSHGRSALNCIAAS--VDLAHAKALECGIATVTVHNCH 371


>UniRef50_Q28KZ8 Malate/L-lactate dehydrogenases-like protein n=1 Tax=Jannaschia sp.
           CCS1 RepID=Q28KZ8_JANSC
          Length = 233

 Score = 71.0 bits (173), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 27/118 (22%), Positives = 39/118 (33%)

Query: 3   VTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDII 62
                L+      L   GV   TA   A+  A     G    G     R I+ +  G I 
Sbjct: 5   YDLSDLEMLAKDCLTRAGVGDATARVVAQDVALAEAYGDAESGFEALLRDIRLVRYGRIY 64

Query: 63  PDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
            DA+    T   A+ + DA          + +   IE A   G+ +V L  A+     
Sbjct: 65  ADAKVNISTPTPAVIRVDAGHGFAAFALAEALPSVIEAALSQGLAMVHLTRASDPGSM 122


>UniRef50_C8Q675 1-aminocyclopropane-1-carboxylate deaminase-like protein n=1
           Tax=Pantoea sp. At-9b RepID=C8Q675_9ENTR
          Length = 245

 Score = 62.9 bits (152), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 189 AGRQLPVDGGFDDEGNLTKEPGVIEKN--RRILPMGYWKGSGMSIVLDMIATLLSDGAS 245
            G +LP +   D+     ++P  + +     +L  G  KGSG+S+V  ++   L+ G +
Sbjct: 2   KGAELPANCAIDNTKKPIRDPRWLMQEPLGALLAFGVHKGSGLSLVCSLLGAALTGGDT 60


>UniRef50_UPI0000E47CD4 PREDICTED: similar to MGC80281 protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E47CD4
          Length = 461

 Score = 55.2 bits (132), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 10/58 (17%), Positives = 28/58 (48%), Gaps = 6/58 (10%)

Query: 206 TKEPGVIEKNRRILPMGY------WKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEY 257
           T +P  +  +  + P+G       +KG+G+++++++I  +L        + + +  E 
Sbjct: 9   TSDPKEVLNDGGLQPLGGGETTGGYKGTGLALMVEVITGILGGAHFGTNIRKWSGGER 66


>UniRef50_UPI00016A6773 hypothetical protein BuboB_33537 n=1 Tax=Burkholderia ubonensis Bu
           RepID=UPI00016A6773
          Length = 103

 Score = 54.8 bits (131), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 22/57 (38%), Gaps = 4/57 (7%)

Query: 192 QLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAE 248
           ++P     D  G  T +P V+ +     P G  KG  ++ + ++    L  G     
Sbjct: 13  RVPAGSLIDHRGRPTDDPAVMHEQ----PFGLHKGYALAAMCEIFGGALGVGGHTTH 65


>UniRef50_Q1YQB4 Putative uncharacterized protein n=1 Tax=gamma proteobacterium
           HTCC2207 RepID=Q1YQB4_9GAMM
          Length = 244

 Score = 51.7 bits (123), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 22/137 (16%), Positives = 41/137 (29%), Gaps = 5/137 (3%)

Query: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60
           MKV+  +L A+  +     G  S      A+M       G    G  R    +  L    
Sbjct: 1   MKVSKNELIASLKKAFEGLGFRSGDYQDAADMVVWLETHGFD--GFERLQAALIYLNA-- 56

Query: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120
             P    + +         D + +   L   + +D             + L +  +    
Sbjct: 57  TKPIHA-ELVQEDTHNAVLDGRGTSILLCGSEAVDLVRSQVMLGSCAAIELFDCYNRSFI 115

Query: 121 GSYGWQAAEKGYIGICW 137
                +AA++ Y  I +
Sbjct: 116 MQRLVKAAQRNYAFIAY 132


>UniRef50_B5JCB7 Putative uncharacterized protein n=1 Tax=Octadecabacter antarcticus
           307 RepID=B5JCB7_9RHOB
          Length = 56

 Score = 50.9 bits (121), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 143 VMPPWGAKECRIGTNPLIVAIP--STPITMVDMSMSMFSYGMLEVNRLAGRQLPVD 196
           ++   G +E  IG NP+ + +P       ++D+++SM +   +   R  G  +P+D
Sbjct: 1   MIATAGGREALIGNNPVRIGVPLSGRDPVLMDIALSMGARSRVRAARDEGDAIPLD 56


>UniRef50_Q9KZG1 Putative uncharacterized protein SCO6991 n=1 Tax=Streptomyces
           coelicolor RepID=Q9KZG1_STRCO
          Length = 68

 Score = 48.6 bits (115), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 10/53 (18%), Positives = 17/53 (32%)

Query: 279 AKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQA 331
           A +   +  +     A     +  PG   T    E   +G+ V   VW  +  
Sbjct: 3   AAVDETLGTLKGPPLAHGADGVYYPGERSTARDVERAADGVPVAPKVWRDLTE 55


>UniRef50_A7IHR1 Putative uncharacterized protein n=1 Tax=Xanthobacter autotrophicus
           Py2 RepID=A7IHR1_XANP2
          Length = 151

 Score = 48.6 bits (115), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 11/45 (24%), Positives = 18/45 (40%)

Query: 117 WMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIV 161
               G    Q A  G +   + N++A +   G      GTNP+ +
Sbjct: 25  CGVVGYRAEQIATAGRVAFGFVNALASIALTGGVTPVFGTNPIAI 69


>UniRef50_Q89R00 Bsr2972 protein n=1 Tax=Bradyrhizobium japonicum RepID=Q89R00_BRAJA
          Length = 75

 Score = 46.3 bits (109), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/53 (22%), Positives = 22/53 (41%), Gaps = 4/53 (7%)

Query: 277 RDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKI 329
            DA++ R +D+    +       + +PG        +  +NGI + D   A I
Sbjct: 8   FDAEVLRHVDF----KPVAGLDQVLIPGDPGRKTRIQRTQNGIPLPDDTRAAI 56


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.161    0.458 

Lambda     K      H
   0.267   0.0497    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,361,350,723
Number of Sequences: 3077464
Number of extensions: 127462604
Number of successful extensions: 362782
Number of sequences better than 1.0e-01: 232
Number of HSP's better than  0.1 without gapping: 611
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 360315
Number of HSP's gapped (non-prelim): 697
length of query: 332
length of database: 1,040,396,356
effective HSP length: 129
effective length of query: 203
effective length of database: 643,403,500
effective search space: 130610910500
effective search space used: 130610910500
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 94 (40.5 bits)
