BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (246 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enteroba... 499 e-140 UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobac... 414 e-114 UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus... 246 5e-64 UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaprote... 241 1e-62 UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacte... 207 2e-52 UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia ... 181 2e-44 UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio... 179 6e-44 UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Paste... 175 1e-42 UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus Re... 172 7e-42 UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrional... 170 4e-41 UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 T... 162 7e-39 UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurel... 156 7e-37 UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio Re... 155 9e-37 UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolum... 154 3e-36 UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas ... 150 5e-35 UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Alloc... 149 9e-35 UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia ... 144 2e-33 UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomon... 134 3e-30 UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shew... 132 1e-29 UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkali... 132 1e-29 UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobac... 131 2e-29 UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methy... 131 2e-29 UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Galli... 120 3e-26 UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma pr... 119 9e-26 UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C... 118 2e-25 UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanel... 117 4e-25 UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomon... 115 2e-24 UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/... 114 4e-24 UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma p... 112 1e-23 UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromon... 111 2e-23 UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptunii... 110 4e-23 UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia ... 110 4e-23 UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacill... 110 4e-23 UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chrom... 110 6e-23 UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomo... 109 1e-22 UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobact... 107 3e-22 UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcu... 106 7e-22 UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassifi... 103 7e-21 UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiob... 101 3e-20 UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gam... 99 9e-20 UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio... 99 1e-19 UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodos... 99 2e-19 UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseud... 98 3e-19 UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteo... 98 3e-19 UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thaue... 97 4e-19 UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomon... 97 5e-19 UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marin... 97 6e-19 UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Terediniba... 96 9e-19 UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggi... 96 2e-18 UniRef50_UPI0001BC6E7F uroporphyrinogen-III synthase, putative n... 95 2e-18 UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 92 1e-17 UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella... 90 6e-17 UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine ... 90 7e-17 UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marin... 89 9e-17 UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/... 89 1e-16 UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sacch... 89 1e-16 UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 89 2e-16 UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Ta... 89 2e-16 UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsie... 88 2e-16 UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococ... 87 7e-16 UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimn... 86 9e-16 UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepI... 86 1e-15 UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456... 84 4e-15 UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyr... 84 4e-15 UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutie... 84 4e-15 UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylopha... 84 5e-15 UniRef50_UPI0001BC6E7E uroporphyrinogen-III synthase n=1 Tax=Buc... 82 2e-14 UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionell... 81 4e-14 UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta prote... 79 1e-13 UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella ch... 76 1e-12 UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella b... 75 2e-12 UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionel... 73 9e-12 UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfu... 73 9e-12 UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivora... 72 1e-11 UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burk... 72 2e-11 UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma p... 72 2e-11 UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Me... 70 5e-11 UniRef50_B4SRW6 Uroporphyrinogen III synthase HEM4 n=4 Tax=Xanth... 70 8e-11 UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangi... 68 2e-10 UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicros... 68 3e-10 UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halot... 67 4e-10 UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobacu... 67 4e-10 UniRef50_Q7VKW9 Possible uroporphyrinogen III synthase n=1 Tax=H... 66 1e-09 UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III... 65 1e-09 UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella... 64 4e-09 UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralston... 63 7e-09 UniRef50_C4GFP3 Putative uncharacterized protein n=1 Tax=Kingell... 63 1e-08 UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lepto... 59 2e-07 UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacil... 58 4e-07 UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea... 57 8e-07 UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERA... 55 2e-06 UniRef50_C0DSC1 Putative uncharacterized protein n=1 Tax=Eikenel... 53 9e-06 UniRef50_B4S2W7 Uroporphyrinogen-III synthetase n=2 Tax=Alteromo... 53 1e-05 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 52 2e-05 UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobact... 52 2e-05 UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillacea... 51 3e-05 UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polyn... 51 4e-05 UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH 51 4e-05 UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chlor... 51 4e-05 UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen... 51 4e-05 UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bac... 50 6e-05 UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uropo... 50 1e-04 UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uropo... 49 1e-04 UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyr... 49 2e-04 UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyri... 49 2e-04 UniRef50_C5ABI2 Uncharacterized enzyme of heme biosynthesis n=5 ... 48 4e-04 UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cry... 47 4e-04 UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 47 5e-04 UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uropor... 47 5e-04 UniRef50_Q4FVJ4 Possible uroporphyrinogen-III synthase n=2 Tax=P... 47 6e-04 UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococ... 47 7e-04 UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bac... 46 0.001 UniRef50_B0TXX7 Uroporphyrinogen-III synthase n=18 Tax=Francisel... 46 0.001 UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=No... 46 0.001 UniRef50_C8PUY1 Uroporphyrinogen-III synthase n=1 Tax=Enhydrobac... 45 0.002 UniRef50_D0SDM4 Uroporphyrinogen-III synthase n=1 Tax=Acinetobac... 44 0.003 UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 44 0.005 UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase ... 44 0.005 UniRef50_C7I1F1 Bifunctional uroporphyrinogen-III synthetase/uro... 43 0.010 UniRef50_A7IEG5 Uroporphyrinogen III synthase HEM4 n=2 Tax=Xanth... 43 0.010 UniRef50_A9CUB7 Uroporphyrinogen-III synthetase n=1 Tax=Hoeflea ... 43 0.011 UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase ... 42 0.012 UniRef50_C7JEW6 Uroporphyrinogen-III synthase n=8 Tax=Acetobacte... 42 0.013 UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepI... 42 0.013 UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pir... 42 0.017 UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonada... 42 0.023 UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus... 41 0.029 UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uropor... 41 0.036 UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desul... 41 0.038 UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured... 41 0.045 UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase ... 41 0.045 UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verru... 40 0.048 >UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enterobacteriaceae RepID=HEM4_ECOLI Length = 246 Score = 499 bits (1286), Expect = e-140, Method: Compositional matrix adjust. Identities = 246/246 (100%), Positives = 246/246 (100%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobacteriaceae RepID=HEM4_SALTY Length = 246 Score = 414 bits (1065), Expect = e-114, Method: Compositional matrix adjust. Identities = 204/246 (82%), Positives = 217/246 (88%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE LVSRLR LGQVAW FPLIEF G++LP LAD+LA L E+DL+FALS Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFA +QL + R WP P YFAIGRTTALALHTVSG I YP DREISE LLQLPE Sbjct: 61 QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGREL+G+TLTARGAEV+FCECYQRCA HYDGAEEAMRW R VT Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGEMLQ+LWSL PQWYREHWLL CRLLVVSERLA LARELGWQDIKVADNADNDA Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) RepID=C4K4E4_HAMD5 Length = 248 Score = 246 bits (628), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 119/245 (48%), Positives = 167/245 (68%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRPSP GEELV ++ G A+H+PLIEFS G+ L +L+ ++ + E D++F +S Sbjct: 1 MVVLVTRPSPMGEELVQFIQAHGHTAYHYPLIEFSQGRDLMELSQRITQMREEDMIFVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A+ + S WP Y+AIGR TA A ++ KI YP ++E SE LL L Sbjct: 61 KTAIDYLASFFKNNPLSWPPSIFYYAIGRNTAQAWQKINPFKIRYPLNQETSEGLLALAN 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I K ALILRGNGGREL+GD L RGA++ +CECYQR +HYDGA+++++WQ +V Sbjct: 121 LQFINKKTALILRGNGGRELLGDRLKKRGAQIIYCECYQRHPVHYDGAQKSIQWQRLKVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS EML ++++L+P+ R WL+ RL+VVS RLA +A LGW I++A+NA N++ Sbjct: 181 TVVVTSEEMLHRIYALVPEEARFAWLIKSRLIVVSARLANIATHLGWHHIQIAENASNES 240 Query: 241 LLRAL 245 LL + Sbjct: 241 LLHTV 245 >UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaproteobacteria RepID=Q491Z5_BLOPB Length = 249 Score = 241 bits (616), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 118/245 (48%), Positives = 159/245 (64%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRPSP GE+LV++L + G+ A+H PLI FS G++L L +L L E D L +S Sbjct: 1 MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHA+ +A +QL WP Y++IG T++ ++ +SG + YP +E SE LLQLPE Sbjct: 61 QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L GKRALILRGN GR ++ DTL RG V CECY R Y+ ++ + Sbjct: 121 LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTSGE+LQ L+ LIP+ YR WL+ C+L+VVS RLAKLAR LGW +I +A +A+N+ Sbjct: 181 TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI 240 Query: 241 LLRAL 245 L L Sbjct: 241 LFHLL 245 >UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacterium RepID=D0Z0U7_LISDA Length = 251 Score = 207 bits (527), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 116/245 (47%), Positives = 144/245 (58%), Gaps = 1/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRPSP GE+L +L +G H PL+ + G ++ L QL L D L A+S Sbjct: 1 MTILVTRPSPDGEQLAHQLCAVGLTVIHQPLLAITSGDEVDLLISQLNWLKSDDFLIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV A + L Q WP+ Y A+G TA L V+GQ +L PQ R SE LL LPE Sbjct: 61 DHAVKLAHNYLQSQGASWPKNVHYMAVGHKTAATLAKVTGQSVLMPQHRCDSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I +R LILRGNGGRELI L AR AEV +CE YQRC + DG A WQ ++V Sbjct: 121 LQQIRHRRVLILRGNGGRELIRQELIARHAEVHYCETYQRCWLPLDGTTLADSWQQQQVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGE L L L+PQ + W L+C L V S+R+A A +LG+ I +A N A Sbjct: 181 KLVVTSGEQLAFLHQLVPQ-HNHAWFLNCHLFVPSQRIADQASQLGFTHISTVGSASNQA 239 Query: 241 LLRAL 245 L L Sbjct: 240 LFTFL 244 >UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W1_WIGBR Length = 245 Score = 181 bits (460), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 89/245 (36%), Positives = 149/245 (60%), Gaps = 1/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRP P G+ L++ +R G+ AW+ PLI F+ G L L + L E D++ +LS Sbjct: 1 MTILITRPYPHGQHLINMIRKNGKEAWYLPLIYFTSGIGLLSLTNFFKKLQEKDIICSLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A +A Q+ + WP+ +Y+AIG+T+A L S K++YP+ E SE LL L Sbjct: 61 PRATKYANYQILLEKCNWPKKINYYAIGKTSAFYLSKYSKCKVIYPKLTENSENLLDLIS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +++ K+ LIL+GN GR+ + + L GA + ECY+R I Y+ + + ++ Sbjct: 121 KEDVK-KKILILKGNNGRKFLENKLKLYGAYIINVECYKRNFIKYNKYDYLKKIINLKIN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTS E+L QL + IP Y +L++ +L+VVS+R++ +A LGW++I V+ ++ N Sbjct: 180 TLVVTSSEILHQLHNNIPLNYINFFLINFKLVVVSKRISDIADNLGWKNIIVSKSSKNKD 239 Query: 241 LLRAL 245 ++++L Sbjct: 240 IIQSL 244 >UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio RepID=B5FF96_VIBFM Length = 253 Score = 179 bits (455), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 101/247 (40%), Positives = 138/247 (55%), Gaps = 6/247 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRP + L L G A PLI PG +L QL ++L + D + A+S Sbjct: 1 MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFSSLNDGDFIIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV + Q L Q +W + +Y A+G+ +A L + YP + SE LL LP Sbjct: 61 QHAVEYTQKYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPTHSD-SEHLLALPV 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN GK+A+ILRGNGGR+LI L +VT+CE YQR AI +D + + WQ + V Sbjct: 120 LQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++VTSGE QL Q+ +W+L RLLV SER+ + A+ELG+Q I+ A N Sbjct: 180 TLIVTSGE---QLSFFTSQFISTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASN 236 Query: 239 DALLRAL 245 LL + Sbjct: 237 SDLLHYI 243 >UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Pasteurellaceae RepID=A6VL86_ACTSZ Length = 249 Score = 175 bits (444), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 97/247 (39%), Positives = 138/247 (55%), Gaps = 3/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP GE+L L G A H PL S G++L +L +++ L D +FA+S Sbjct: 1 MAVLVTRPDSRGEQLTEALNKAGVAALHMPLFSISAGRELNELPNKMYQLKAGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L +W + YFA+G+++A S Q + YP E SE LL LP+ Sbjct: 61 KNAVEFAAETLSNTGFRWRQDLIYFAVGQSSAEYFCEQSEQPVHYPYGHENSEGLLALPQ 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + K LILRGNGGREL RGA+V ECY+R + YD ++ Q + Sbjct: 121 MQRLTDKTVLILRGNGGRELFPAQAVRRGAQVEIIECYRRVPVEYDPKKQTDLCQRAGIN 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD--IKVADNADN 238 ++ TS E+L +L + +P R+ WL CRL+ S R+AK A GWQ I +A ADN Sbjct: 181 TIIATSSEILTRLTNFVPAEERD-WLTQCRLVTASYRVAKSAERAGWQKRQILIAPRADN 239 Query: 239 DALLRAL 245 L++ L Sbjct: 240 ATLVKML 246 >UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus RepID=HEM4_PROMI Length = 199 Score = 172 bits (437), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 94/195 (48%), Positives = 121/195 (62%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE+L RL G+ A+H PLIE + G++L L ++L L D LF LS Sbjct: 1 MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV +A QL+Q + WP Y+ IG++TA ++ I YP+ E SE LL L Sbjct: 61 KNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I KR L+LRGNGGREL+ TL RGA V CECYQR I Y E A++W+ +V Sbjct: 121 LQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVE 180 Query: 181 MVVVTSGEMLQQLWS 195 + EMLQQL S Sbjct: 181 YLCGHQCEMLQQLLS 195 >UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrionales RepID=B7VME0_VIBSL Length = 242 Score = 170 bits (430), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 100/246 (40%), Positives = 139/246 (56%), Gaps = 5/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G+ L +L G A H PLI P +D L SD++ A+S Sbjct: 1 MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDN---PHSSDLSTQLNNSDIIIAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV AQ+ L + WP P Y +G+ TA L VS QK+ YP+ + SE LL+L E Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPKVSD-SEHLLKLTE 116 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + K LILRGNGGRELI D+L RGA+V++CE Y+R I + W ++ + Sbjct: 117 LNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKTS 176 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV+TS E L+ L S+ P Y WL +L V S+R+ + A++LG+ ++ +A N Sbjct: 177 KVVITSQEQLEYLCSITPDEYLA-WLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQI 235 Query: 241 LLRALQ 246 LL ALQ Sbjct: 236 LLAALQ 241 >UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 Tax=Moritella sp. PE36 RepID=A6F8Y8_9GAMM Length = 255 Score = 162 bits (411), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 90/243 (37%), Positives = 135/243 (55%), Gaps = 2/243 (0%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 L+TRP GE+L ++ A P I+ S GQQ +++ LA L D + A+S +A Sbjct: 6 LITRPRVKGEQLARQIEAADGAALCCPFIDISAGQQFTKVSSLLAELQPDDYIIAISDNA 65 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 V +A + L +R WP+ +Y A+G TTAL+ P D SE +L+L + Sbjct: 66 VNYANTSLINANRTWPQQINYIAVGPTTALSWQKYGINHAQIP-DTHDSEGVLKLLANAS 124 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + K+ +ILRGNGGRE + + LT R A VT+CE YQR A YD +WQ + V+ Sbjct: 125 VEHKKIVILRGNGGRETLAEDLTKRTANVTYCEVYQRTAPDYDPDMLINKWQQFAINSVI 184 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 +TSGE+L L IP + W+L+ +V S+R+A LA LG + + +A A N++L Sbjct: 185 ITSGEILGNLIKTIP-YTALPWILNLHFIVPSQRIAALAHTLGIEHVTIATGASNNSLFN 243 Query: 244 ALQ 246 A++ Sbjct: 244 AIK 246 >UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurellaceae RepID=B8F5M2_HAEPS Length = 252 Score = 156 bits (394), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 96/249 (38%), Positives = 134/249 (53%), Gaps = 7/249 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G +LV L A H PL G LP L L+ L D +FA+S Sbjct: 1 MNVLVTRPDQRGLQLVEMLAEQQIFAIHQPLFRVEAGADLPTLPSSLSRLNSGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L Q W YFA+G+ +A + Q + YP E SE LL LPE Sbjct: 61 KNAVDFATETLKQTGFYWRSDLLYFAVGQRSANHFASQIEQAVRYPIQSENSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + ++GK LILR + GRE + T+RGAEV ECY+R + + +E+ + Sbjct: 121 MAQLSGKNVLILRADTGREFFAEQATSRGAEVQILECYRRIMLADNLSEQISLAKRAGTD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREH--WLLHCRLLVVSERLAKLARELGWQD--IKVADNA 236 +VVTSGE+L + I Q WL CRL+VV +R+A LAR+ GW+ I+++ A Sbjct: 181 TIVVTSGEILT---TFIEQTAEADLPWLYQCRLIVVGKRIATLARKSGWKSEQIQISMKA 237 Query: 237 DNDALLRAL 245 DN +LL + Sbjct: 238 DNHSLLETI 246 >UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio RepID=A5F4J2_VIBC3 Length = 260 Score = 155 bits (393), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 102/247 (41%), Positives = 136/247 (55%), Gaps = 9/247 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G EL L G A H PL+ S QL LA+ L++ D++ A+S Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSF---DIIIAVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV F+ L + WP Y A+G+ TA Q + YP+ + SE LL L Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L+++AGK+ LILRGNGGRELI TL RGA V + E Y R + AE +WQ +V Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREH--WLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +V+TS E QL I Q+ H W+ LLV S+R+A LA +LG+ I V +A N Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238 Query: 239 DALLRAL 245 L+ AL Sbjct: 239 RDLVAAL 245 >UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolumonas auensis DSM 9187 RepID=C4LDV5_TOLAT Length = 241 Score = 154 bits (388), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 98/245 (40%), Positives = 136/245 (55%), Gaps = 6/245 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ L+ RP PA EL + LR G PL+ + PG +L L A L ++++ A+S Sbjct: 1 MTPLILRPQPAAGELAAYLRRDGHTPVVCPLLTYQPGDELALLP---ALLKQAEITLAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV FA L QQ WP Y A+G TA A G +++ P D SE LL P Sbjct: 58 AAAVQFASRHLQQQKILWPPALTYLAVGPATA-AEWQQQGLRVISPADAR-SEGLLAQPA 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ GK+ +ILRGNGGREL+ +TL RGA+V+ ECY+R + DGA WQA V Sbjct: 116 LQSVNGKKIVILRGNGGRELLTETLRHRGAQVSCVECYRRHYLQTDGARLLQEWQAAAVD 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E+ +QL L+P +WL R V SER+A+ R G++ I + A + A Sbjct: 176 SVIITSSELFRQLLILLPD-TAGNWLSALRWFVASERIAEEIRHSGFKQITIMSGAQHQA 234 Query: 241 LLRAL 245 + AL Sbjct: 235 VAAAL 239 >UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas RepID=A0KFH5_AERHH Length = 244 Score = 150 bits (378), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 106/247 (42%), Positives = 141/247 (57%), Gaps = 9/247 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M LV RP+ EL + LR G PL+E G +L +L + L ++D++ A+S Sbjct: 1 MIPLVVRPAAQAAELAALLRQHGHAPLCCPLLETVAGSELHRLPELLP---QADIVIAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV F L Q + WP + DYFA+G+ +A A V G + L P D SE LL LP Sbjct: 58 VHAVNFTHHFLLQTGQTWPNI-DYFAVGQASADAFSEV-GIQALSPDDPR-SEGLLALPS 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ + GK+ LILRGNGGR+LI TL +RGA V +C Y+R DG WQA + Sbjct: 115 LQQVNGKQVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPALDGDALTCHWQAAGLD 174 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV-SERLAKLARELGWQDIKVADNADND 239 ++VTSGE+LQ+L L+P W LH RLLVV S R+A++A G+ I +A A N Sbjct: 175 SLLVTSGELLQRLLELVPDQQLP-W-LHDRLLVVPSPRVAEMAAAAGFTHITIAQGASNQ 232 Query: 240 ALLRALQ 246 AL AL+ Sbjct: 233 ALTAALE 239 >UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5J5_CHRVI Length = 251 Score = 149 bits (376), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 99/244 (40%), Positives = 135/244 (55%), Gaps = 9/244 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES-DLLFALSQ 61 +LVTRP+ E L + + G A FP I P + A L ES DLL+ +S Sbjct: 12 VLVTRPAGQAEPLCRLIESAGGRAIRFPTIAIEPTHD----PEATALLAESWDLLYFVSP 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV Q+Q D WPR+ A+GR TA AL L P DR SE LL++PEL Sbjct: 68 NAVE--QAQALVADGTWPRVERVAAVGRGTARALEAAGRAPDLVPNDRYESEALLEMPEL 125 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++ G+R LI+RG GGR L ++ RGAEV F E Y+R D A W+ EV Sbjct: 126 SDMRGRRVLIVRGVGGRGLFAQAMSERGAEVRFAEVYRRARPAVDVAPLLAHWR-EEVDF 184 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V+ TS E+L L L+ Q + LL L+V++ER A+ AR LG+Q I+VA+ AD+ ++ Sbjct: 185 VMATSDEVLLNLAELLGQEGQAS-LLATPLVVIAERTAQTARNLGFQTIRVAERADDSSI 243 Query: 242 LRAL 245 +RAL Sbjct: 244 VRAL 247 >UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0I363_VIBHO Length = 257 Score = 144 bits (364), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 95/246 (38%), Positives = 124/246 (50%), Gaps = 2/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LV RP+PA ELV L G A PL+ FS G+ LP L + L ++ A+S Sbjct: 1 MTVLVVRPAPACYELVETLNQSGIKALPAPLLSFSEGKDLPVLTNTYRRLPSGSVVVAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A+ + Q Q + W Y A+G TA SG L P E SE +L L Sbjct: 61 PRAIEYTQQQFRNDNTAWRDDLHYVAVGEKTAQVWLEESGINALQP-PTEDSEGMLSLSV 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LILRGNGGR L+G TL +RGA+V + E YQR AM+WQA V Sbjct: 120 FGEPEHLEVLILRGNGGRALLGKTLASRGAKVHYFEAYQRHWTSDSLLSLAMQWQAENVD 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGE L L I + + WL C +LV S+R+ A LG+ I+ ++A N A Sbjct: 180 TLVVTSGEQLSLLCQTISE-SNQQWLRECHILVPSKRIYNQAIGLGFNTIRCVNSASNTA 238 Query: 241 LLRALQ 246 L AL Sbjct: 239 LFHALN 244 >UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomonadaceae RepID=Q0AH88_NITEC Length = 260 Score = 134 bits (337), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 81/229 (35%), Positives = 122/229 (53%), Gaps = 2/229 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 SIL+TRP L +R++ LG W FP++E S + L D +A L + DL +S Sbjct: 10 SILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSP 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV +H + R+WP +G+ +A AL ++ P+D SE LL++P+L Sbjct: 70 NAVERVMPLVHAE-RRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQL 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + GKR +I RGNGGR+L+GDTL RGA V + ECY+R D W + Sbjct: 129 QIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKYWHDNGIQA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 VV++S E L L+ +I + ++ L + +R+ ARELG + I Sbjct: 189 VVISSSEGLDNLFDMIGKTGQQ-LLRATAVFTAHDRIECKARELGIRKI 236 >UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shewanella RepID=A4YBG3_SHEPC Length = 246 Score = 132 bits (332), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 126/249 (50%), Gaps = 7/249 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +L+TRP + +V L G + PL+ P + D L +D++ +S Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGITHYVTPLLGVEPTNDI--TTDASHPLAGTDIIICIS 58 Query: 61 QHAVAFAQSQLHQ---QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 +AV FA L++ Q WP++ YFA+G T AL + + P D + +E LL Sbjct: 59 ANAVIFANKALNKINAQIATWPKV-QYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLT 117 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 L LQ+I K+ I+RG GGRE + + LT RGA V + E YQR DG +WQ Sbjct: 118 LASLQHIPAKKVTIIRGVGGREALAEQLTRRGANVRYWEVYQRVCPPLDGYAITQQWQHF 177 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + +VVTSGE+L L L+P+ WL C ++V S R+ A G + A A+ Sbjct: 178 GIDTIVVTSGEVLNNLIKLVPKELFA-WLRSCHIIVPSNRVEAQAHAFGINHVTNACAAN 236 Query: 238 NDALLRALQ 246 + A+L AL+ Sbjct: 237 SKAVLNALK 245 >UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkalivibrio RepID=B8GSU7_THISH Length = 272 Score = 132 bits (331), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 87/248 (35%), Positives = 136/248 (54%), Gaps = 9/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEF---SPGQQLPQLADQLAALGESDLLFA 58 +LVTRP+ E + G V FP++E +L L D+L A D+ Sbjct: 17 GVLVTRPAHQAEVFCRMIEQAGGVPLRFPVLEILEPRDSGRLDALIDRLDAF---DIAIF 73 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S +AV+ A +++H + R WP A+G+ +A L + P R SE LL+ Sbjct: 74 ISPNAVSMAVNRIHAR-RPWPEHLRIGAVGQKSAQELARAGHPAHICPPRRFDSEALLEE 132 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 PELQ++AGKR +I RG+GGREL+GDTL RGA V + E Y+R D + + W E Sbjct: 133 PELQDVAGKRIVIFRGDGGRELLGDTLKERGAVVEYAEAYRRGRPDADTGKLMIHWSRGE 192 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIKVADNAD 237 + +V TS E L+ L+ ++ + R WL LLV + R+ + ARELG+ D VA++ Sbjct: 193 LHLVTSTSSEGLRNLFDMVGKLGR-MWLRKTPLLVGAPRMVETARELGFNGDPWVAEDPS 251 Query: 238 NDALLRAL 245 ++++++A+ Sbjct: 252 DESMMQAV 259 >UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobacillus flagellatus KT RepID=Q1GX91_METFK Length = 256 Score = 131 bits (330), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 86/244 (35%), Positives = 123/244 (50%), Gaps = 3/244 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I +TRP L S + G A FPLI +P Q L + D L +S + Sbjct: 9 IAITRPLDQATRLTSMIEAAGGHAIGFPLIAIAPLQDYSSFEQTLDEVTMQDWLIFISSN 68 Query: 63 AVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV A S+L + +WP P + AIG TA L +L P+ R SE LL LP++ Sbjct: 69 AVQHAMSRLQAKLPQWPPAKPQFAAIGPVTASQLMQYGITNVLQPEHRFDSESLLALPQM 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G R +I+RG GGREL+ DTL RGAEV F ECY+R D + W ++ Sbjct: 129 QAVKGLRIMIVRGVGGRELMADTLRDRGAEVRFAECYRRINPQADAGKLQSLWHNGQLDT 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +VVTS E ++ L ++ E WL + V R+A+L LG + + +A +DA+ Sbjct: 189 IVVTSSEAMRNLLAMTGSGTAE-WLRDITICVNHARIAELPSSLGLR-VLIASAPGDDAM 246 Query: 242 LRAL 245 ++ L Sbjct: 247 MQCL 250 >UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methylophilaceae RepID=C6X7P0_METSD Length = 267 Score = 131 bits (329), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 88/246 (35%), Positives = 126/246 (51%), Gaps = 2/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 +S+ +TRP L + G + FPLIE +P QL LG+ D +S Sbjct: 14 LSVAITRPLDQATRLSRLIVEAGGTPYGFPLIEIAPLADYSAFDAQLHELGKYDWTIFIS 73 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV A ++ + P + AIG TA L ++ +L PQ R SE LL LPE Sbjct: 74 SNAVQNAIPRMLNLVGQPPATLRHAAIGPVTAAELTSLGIGPVLTPQGRYDSESLLALPE 133 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + G+R LI RG GGREL+ ++L ARGA V F ECY+R RWQ +++ Sbjct: 134 MQQVKGQRFLIFRGVGGRELLAESLRARGATVDFAECYRRINPQTSAEPLEQRWQQQQLD 193 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS E ++ L ++ + W+ L V R+A+L ELG I VA+ +DA Sbjct: 194 AVVVTSSEAMRHLLNMTNNG-QHAWIRDVTLCVNHARIAELPIELGLHVI-VAEAPGDDA 251 Query: 241 LLRALQ 246 +L+ L Sbjct: 252 MLQCLN 257 >UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Gallionella ferruginea ES-2 RepID=C5V3N2_9PROT Length = 248 Score = 120 bits (302), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 83/247 (33%), Positives = 126/247 (51%), Gaps = 17/247 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +LVTRP L + G A FP++E +P L +L +Q++ + +++L +S Sbjct: 9 LKVLVTRPRDQAFTLAQAIGQQGGTAVLFPMLEIAPVPDLLRLQEQVSHVEQANLAIFIS 68 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFA-IGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + + ++P A +G +A AL + ++ P +R SE LL P Sbjct: 69 PNAVKYGMAA------TGGKVPARVATVGEGSAKALRALGIAHVIVPVERFDSEGLLARP 122 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ELQNI G +I RG+GGREL+GDTL RGA V + CY RC +E A V Sbjct: 123 ELQNIDGWHVMIFRGDGGRELLGDTLRERGARVEYVTCYLRCKPQCPVSELA------GV 176 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 ++ VTS E L L +I + L V+ R+A+LA+ LGW + + ++ D D Sbjct: 177 DLITVTSSEALNHLSQMI---VDSKEVFDRPLFVIHPRIAELAKRLGWSKVHLTESGD-D 232 Query: 240 ALLRALQ 246 LL LQ Sbjct: 233 GLLAGLQ 239 >UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSU1_9GAMM Length = 243 Score = 119 bits (298), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 89/249 (35%), Positives = 131/249 (52%), Gaps = 18/249 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILV RP ++ + L G H P++ P + + + + D +S + Sbjct: 5 ILVIRPLRQADQFIELLERAGNQVCHIPVMAIEPVVDGQSIKNLILEVDNFDKAICVSGN 64 Query: 63 AVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKI--LYPQDREISEVLLQ 117 A A L DR WP P +YFAIG+ TA H + I L P R+ SE LL Sbjct: 65 AAELAIEWL---DRYWPMQPVGIEYFAIGQQTA---HILGAADIVALSPSGRQNSEALLA 118 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LPELQ+++ +R ++ RG GGRE++GDTL RGA V +CE Y+R I+ A A R Q Sbjct: 119 LPELQDLSDQRVIVFRGRGGREILGDTLIERGARVDYCELYERV-INPQKALLA-RKQML 176 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 E +V SGE+L L + E ++V SER+A++A +LG+++I A+NA Sbjct: 177 ESDCLVAHSGELLTALGDQSGESGAE-----TAVVVPSERVAEIAWKLGYRNIVSAENAL 231 Query: 238 NDALLRALQ 246 +A+L A+Q Sbjct: 232 PEAMLAAVQ 240 >UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase n=1 Tax=Methylococcus capsulatus RepID=Q602K2_METCA Length = 672 Score = 118 bits (295), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 93/250 (37%), Positives = 138/250 (55%), Gaps = 11/250 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP E L + T G A FPL++ P Q + A L + D +S Sbjct: 1 MRVLVTRPKEQAEPLCRLIETAGGKAVRFPLLDIEPSAQAEEGAALLRQASDWDWWIFVS 60 Query: 61 QHAVAFAQS-QLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV A++ + + D PR+ AIG+ TA AL L P+ + SE LL+ P Sbjct: 61 VNAVNRARALDVLRPDGAGPRI---AAIGKATADALVDGGIAVDLVPESQANSEGLLETP 117 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE---EAMRWQA 176 ++++AG+R LI+RG GGRE + + L RGA V + E Y+R +H GAE E +R Sbjct: 118 PMRDVAGRRILIVRGEGGRETLKERLVERGALVQYAELYRRVPVHT-GAEALIEGLRTAG 176 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + M+ TSGE ++ L+ L+P R L+ L+V+SERL A LG++ +KVAD A Sbjct: 177 --LDMLTATSGEAIEHLYRLVPPEDRPR-LVETPLVVISERLKNQAGSLGFRHVKVADAA 233 Query: 237 DNDALLRALQ 246 + A+L+AL+ Sbjct: 234 SDAAVLQALE 243 >UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanella marisrubri RepID=Q1MZM6_9GAMM Length = 255 Score = 117 bits (292), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 85/255 (33%), Positives = 131/255 (51%), Gaps = 20/255 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP-----GQQLPQLADQLAALGESDLL 56 S+LVTRP G+ ++ L G H PL++ P G QL ++ L D + Sbjct: 3 SLLVTRPQGQGQGMMIELEQAGIQVVHQPLLKIEPLKMEDGADYHQLKQRIVDLDLYDTV 62 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTA---LALHTVSGQKILYPQDRE 110 +S +A A + D+ WP+LP +FA+G ++A L L + I P+ Sbjct: 63 ICVSSNAAQLASDWI---DQYWPQLPVKQQWFAVGPSSAEPLLPLLDSAAMDIQVPEGNH 119 Query: 111 ISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE 170 SE LL LP+L+++ K+ LILRG GGRELI TL RGA V + E Y+R + + Sbjct: 120 -SEGLLALPQLRDMTEKKVLILRGVGGRELIKSTLEERGASVHYAEFYRRTPVDLTQQQL 178 Query: 171 AMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 ++ ++TSGEM+QQ +P ++ LH LLV SER+ K+A +LG+Q Sbjct: 179 QTLLTEHQIHYALLTSGEMVQQFHQALPNTPKD---LH--LLVPSERIQKMAIDLGFQQT 233 Query: 231 KVADNADNDALLRAL 245 + A+L+++ Sbjct: 234 HICQPITAQAVLKSI 248 >UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MCU1_9PROT Length = 261 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 2/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ILVTRP L + G P++E + + L D + L E D +S Sbjct: 10 INILVTRPLHQSTFLAENIHASGGKPILLPVLEITDVTDITPLLDLINRLDEFDWAVFVS 69 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + + +Q R P A+G+ TA L ++L P + SE LL+ E Sbjct: 70 PNAVIKSMDLITKQ-RALPPDLKIAAVGKGTADTLRRYGVNRVLIPIEHFDSEALLKSEE 128 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN+ K +I RGNGGR L+GDTL RGA + + ECY R D A W ++ Sbjct: 129 LQNMTEKHVVIFRGNGGRALLGDTLAQRGAHIEYAECYLRRKPEIDSAPLLAAWSQGKIH 188 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E L L+ +I ++ L + +R+A+ ARELG + I A ++ Sbjct: 189 AVIITSSEGLHNLFDIIGTLGQQ-LLKTTPIFTAHDRIAQAARELGLKKIVKVPYAGDEG 247 Query: 241 LLRAL 245 LL+ L Sbjct: 248 LLKGL 252 >UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=1 Tax=Pseudoalteromonas tunicata D2 RepID=A4CFD4_9GAMM Length = 614 Score = 114 bits (284), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 84/247 (34%), Positives = 125/247 (50%), Gaps = 15/247 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTRP G ELV++L+ LG A FPL+ P L + LA LGE+D L +SQ Sbjct: 4 ILVTRPDTKGAELVAQLKKLGHHAISFPLLALEP---LAVSSAALAPLGEADKLIFISQD 60 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK--ILYPQDREISEVLLQLPE 120 AV L+ P +FA+G TA + + G K I PQD SE LL L E Sbjct: 61 AV----KALYALKPNLKHQPQFFAVGEKTAAVIAELFGVKARIAKPQD---SEGLLALKE 113 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ+I + ++L+G GR LI L RGA V Y+R + + +WQ +++ Sbjct: 114 LQHIEQQNIVLLKGQDGRPLIAQKLKQRGAFVHAVVLYRRQPVKGVASGWIKQWQQQKID 173 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE--LGWQDIKVADNADN 238 +V+TS + ++ + + WL CR V SER+A + + +I++ A + Sbjct: 174 SIVLTSNAAVDAIFRELAE-NEVKWLKTCRFYVASERIANYLSQFAIAANNIQICAGASD 232 Query: 239 DALLRAL 245 +A+L A+ Sbjct: 233 EAILTAI 239 >UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KSU6_9GAMM Length = 679 Score = 112 bits (280), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 82/245 (33%), Positives = 131/245 (53%), Gaps = 7/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TRP L + L G + P++ P P D L AL ++DL +S Sbjct: 4 TVILTRPQEDSARLAAILAERGWDVFVQPMLRMEP--LAPAAIDALPALTDNDLAIFISA 61 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV L ++ R + A+GR TA L +G ++ P DRE SE LL LP L Sbjct: 62 NAVRQGLPHLAERLRDAGMV--SLAVGRRTAQELE-AAGLPVMTP-DREDSEGLLALPAL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + I+G R L+++G GGR ++ +TL RGAEV CYQR D + A R + Sbjct: 118 REISGHRVLLVKGEGGRAVLAETLRTRGAEVIEFVCYQRVNESLDATDFAGELAKRRPLV 177 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + +S + L+++ L+ + + + L+ ++V SER+A++A ELGWQ + A NA ++A Sbjct: 178 IQASSEQTLRRVTELLAEGGQPN-LVAENVVVPSERVAQVAAELGWQHVITAPNAGDEAF 236 Query: 242 LRALQ 246 LR L+ Sbjct: 237 LRVLE 241 >UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromonas RepID=A1T0Q9_PSYIN Length = 244 Score = 111 bits (277), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 83/230 (36%), Positives = 121/230 (52%), Gaps = 6/230 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTR +P + LV+ L G VA+ PL+ + + LA D + A+S + Sbjct: 6 LLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAK--NYDYIIAVSPN 63 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV + Q L + WP+ +Y A+G T L + Q ++ P+ SE LL LP L Sbjct: 64 AVDYTQKALAGIN--WPQ-TEYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLL 120 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 N+ GK LILRG GGREL+ DTL RGA V + + YQR AI G WQ + + Sbjct: 121 NLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNINGA 180 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 +++S E+L++L S++P E WL + SER+ A+ GW + KV Sbjct: 181 IISSIELLERLMSVVPLAAHE-WLKELTIYAPSERILDQAKRWGWSNTKV 229 >UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BL64_9GAMM Length = 260 Score = 110 bits (276), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 79/255 (30%), Positives = 130/255 (50%), Gaps = 14/255 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ----LADQLAALGESDLL 56 + +LVTRP+ + L L G FPL++ +P L Q+ L + Sbjct: 8 LRVLVTRPAHQADTLYELLLQQGADPVRFPLLQITPVTSADSGFHLLKQQIIDLDLFQHI 67 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREISE 113 +S +AV + D+ WP+LP + AIG+ +A L+ P + SE Sbjct: 68 IFISPNAVELGYEWI---DQYWPQLPLGVQWLAIGKQSAARLNNYGIDAYHSPLGYD-SE 123 Query: 114 VLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 LL P LQ IAG + LI+RG GGRE + + L ARGAEV++ E Y+R + Y E + Sbjct: 124 ALLNSPALQKIAGDKVLIMRGEGGRETLAEELRARGAEVSYAELYRRESPCYSAKEISDA 183 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYRE---HWLLHCRLLVVSERLAKLARELGWQDI 230 ++ + ++++SG L+ L +L+ +E LL+C L+V S+R+ + A+ +G+ I Sbjct: 184 LLSKHLDAILISSGAGLKNLITLLSSTGKELSTDSLLNCHLIVPSDRIKQEAQGVGFNRI 243 Query: 231 KVADNADNDALLRAL 245 A D+ +++ AL Sbjct: 244 TTASGPDDRSMIAAL 258 >UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia psychrerythraea 34H RepID=Q48AW9_COLP3 Length = 253 Score = 110 bits (275), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 86/257 (33%), Positives = 129/257 (50%), Gaps = 25/257 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP ++L L G + L ++ Q+ D AL +D+L +S Sbjct: 6 LKVLITRPKAKAQQLALLLNQQGILNTSQTLFDY---QKNASANDIATALENADILIFVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD-----YFAIGRTTALALHTVSGQKILYPQ-DREISEV 114 AV FA + +P LP+ FA+G T AL + IL P +E SE Sbjct: 63 VAAVEFAHAS-------YP-LPNNLSQTIFAVGNATKKALQAIGMTTILSPPPQQEHSEG 114 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRC--AIHYDGAEEAM 172 LL+LP+L + GKR +I RGNGGRE I ++LT RGAEV + E YQR + AE+ Sbjct: 115 LLKLPQLSKVIGKRIIIFRGNGGREHIANSLTLRGAEVRYIESYQRVWRTLPIIIAEQ-- 172 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYR---EHWLLHCRLLVVSERLAKLARELGWQD 229 W+A+++ +VVTS ++L L + +W C +VVS+R+ K A+ LG + Sbjct: 173 -WRAQKINCIVVTSNDILLALLKYLASTTNSTDNYWQSQCLWVVVSDRIEKNAKALGLKR 231 Query: 230 IKVADNADNDALLRALQ 246 + A + L LQ Sbjct: 232 VINTHGASSQILCNTLQ 248 >UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacillus denitrificans ATCC 25259 RepID=Q3SFT6_THIDA Length = 252 Score = 110 bits (275), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 82/238 (34%), Positives = 115/238 (48%), Gaps = 11/238 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLP--QLADQLAALGESDLLFAL 59 +ILVTR L + +R G A+ FP + F + +P +L LA + +D + + Sbjct: 9 TILVTRAPRQAAALSAAIRAAGGSAFEFPALAF---EAVPVDRLQASLAQVVAADFVIFV 65 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S +A F + + A+G TA AL ++ P D + SE LL LP Sbjct: 66 SPNAAEFGMAAIGSLAAGR----SVLAVGPGTARALAAQGLDAVITP-DGQDSEALLALP 120 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 +L ++ GKR +I+RG GGR L+GDTL ARGAEV + ECY+R A D A RWQA + Sbjct: 121 QLLDVDGKRVVIVRGIGGRALLGDTLAARGAEVHYMECYRRLAPTADAAPLIARWQAGGI 180 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 V V S E L L +L+ + L H L E++A AR G D Sbjct: 181 DAVTVASAETLHNLAALLGE-AGAPLLAHTPLFAPYEKIAAAARSFGVAQATATPGGD 237 >UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QSV6_CHRSD Length = 251 Score = 110 bits (274), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 91/252 (36%), Positives = 126/252 (50%), Gaps = 20/252 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDL-LFALSQ 61 I+VTRP G LV L T G A H L+ P AD++ D L+ + Sbjct: 7 IVVTRPGEGGRRLVDALSTAGFEAVHPALMTLQP-----LAADEVERGAVLDFDLYDVVV 61 Query: 62 HAVAFAQSQLHQ-QDRKWPRLPD---YFAIGRTTALALHTVSG--QKILYPQDREISEVL 115 FA L + DR WP+LP ++A+G +TA LH G K+ P SE L Sbjct: 62 VTSPFAAECLDEWIDRYWPQLPQGPRFYAVGASTAATLHRTLGIKAKVPDPARGTTSEAL 121 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L + L + G+RALI+ G+GGR+++ + L ARGA V Y+R D E + W Sbjct: 122 LAMRSLTRLDGQRALIVGGSGGRQVMAEALEARGARVAKLALYRRVYTAPD--EVTVDWL 179 Query: 176 AR-EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 A T ++VTSGE+L+ L S Q L+ L+V S+RLA LA +G+ VA Sbjct: 180 ASGAFTAMIVTSGELLEHLVSWCGQAA-----LNKPLIVSSQRLATLADTMGFASPHVAS 234 Query: 235 NADNDALLRALQ 246 A DAL+ A+Q Sbjct: 235 GATPDALVTAVQ 246 >UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6B4_9GAMM Length = 253 Score = 109 bits (272), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 76/251 (30%), Positives = 131/251 (52%), Gaps = 16/251 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP-GQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP P R +T G + P+IE +Q + + L D + +S+ Sbjct: 8 ILITRPEPENTLSCERFQTWGAHSLSLPMIEIDALTEQNAAIQSHIFDLDLYDQVIFISK 67 Query: 62 HAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREIS----EV 114 +AV + + + WP LP ++ IG+ T ++ + + Q+ +S E Sbjct: 68 NAVRYG---IEWIEDCWPMLPVGINWVGIGKGTTDFINELGFDLGIKAQEHALSGNTSEA 124 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 LL +Q +AG++ LI+ G GGR + +TL RGA+V Y R I+YD + A Sbjct: 125 LLNQESMQKVAGQKILIMGGEGGRTKLAETLLERGAQVKHLALYSRNKINYDLEQVA--- 181 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 +A ++++TSGE L+ L + Q + ++W LH +L S+R+A +A ELGW+++ A+ Sbjct: 182 EAENCEVILITSGEGLENLVDTLSQ-HNKNW-LHKLILTPSQRVADMAIELGWKNVVNAN 239 Query: 235 NADNDALLRAL 245 AD++++ AL Sbjct: 240 GADDNSIYAAL 250 >UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobacterium violaceum RepID=Q7P209_CHRVO Length = 243 Score = 107 bits (268), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 91/246 (36%), Positives = 122/246 (49%), Gaps = 15/246 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES-DLLFALSQ 61 +L RP L+ +LR G A H PL+E P LP+ L A D LF +S Sbjct: 4 VLAARPLAQCAGLLEKLRAEGWQAGHLPLMEIEP---LPEALAALPAQAARADALFWVSP 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ L D RL +G +A L +SG+ +L+P SE LL LPEL Sbjct: 61 SAIDVGWPALAGMDFSGKRL---ACVGAASARRLADLSGRPVLHPTAGSDSEALLALPEL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + +G+R LI+RG GGR L+ DTL ARGAEV E Y+R DGA + + A Sbjct: 118 ADASGQRWLIVRGQGGRPLLADTLAARGAEVGVAEVYRR----VDGAPDWAAFDAAPPDA 173 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSE-RLAKLARELGWQDIKVADNADNDA 240 V++TSGEM++QL+ L R L C L V R+A+ G I V AD+ A Sbjct: 174 VIITSGEMVEQLFRLAGP--RRTGALQCLLYCVPHPRIAERLAAFGAARI-VTTRADDAA 230 Query: 241 LLRALQ 246 L+ L+ Sbjct: 231 LVAGLK 236 >UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS89_9GAMM Length = 267 Score = 106 bits (265), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 87/248 (35%), Positives = 118/248 (47%), Gaps = 8/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP+ E L G A PL+ S + P A A L DLL S Sbjct: 17 NIVVTRPAHQAESFCRMLEHAGANALRCPLLNISATPKTPSFARLRAELASFDLLIFNSP 76 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A F QL Q R R+ AIG TA A+ + + P SE LL+LP L Sbjct: 77 NAANFGLPQLEPQRRLQGRV-KIAAIGAKTAHAIAGLGYSVDIVPATGFDSESLLELPIL 135 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE--EAMRWQAREV 179 + + G + ILRG+GGREL G L +RGAEV++ + Y+R + E E + R Sbjct: 136 EKVGGMKIAILRGSGGRELAGSVLRSRGAEVSYIQVYERQPPSKEQFEQIEQLLLHNRS- 194 Query: 180 TMVVVTSGEMLQQLWSLI-PQWYREHWLLHCRLLVVSERLAKLARELG-WQDIKVADNAD 237 V +TSGE LWS I P+ H L + S R+A +AR G I VA + Sbjct: 195 DAVAITSGEAFLALWSGIGPRLC--HLLNQSTFVFGSRRIADVARSKGLCSPIAVAADPS 252 Query: 238 NDALLRAL 245 ++A+ AL Sbjct: 253 DEAMFAAL 260 >UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassified Gammaproteobacteria RepID=A4A9F8_9GAMM Length = 261 Score = 103 bits (256), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 120/237 (50%), Gaps = 9/237 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQ-LAALGESDLLFALSQ 61 +LVTRP+ + L+ L G V H P+++ P LP Q L L + +S Sbjct: 7 VLVTRPAGQADSLIGALSDAGFVPLHLPMLQIEPLDPLPGAQRQRLMDLDRYAHVIFVSA 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +A ++ WP+LP Y+A+G++TAL L G + P+ SE LL + Sbjct: 67 NAARLGVERIRD---YWPQLPQGQLYWAVGKSTALCLEA-EGLDVRRPERDMSSEGLLAM 122 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 P L + +R LI++G GGR+ + L RGAEV CY+R +D + Sbjct: 123 PGLAELQSQRVLIVKGEGGRKFLEVKLRERGAEVDSLACYRRDYAAHDRQACRDLLGDHD 182 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + +++V+SGE L++L SL+ Q L LLV S+R+A+ A LGW ++ A+N Sbjct: 183 LALILVSSGEGLERLTSLL-QPEEHTNLAMTTLLVPSQRVAEQALGLGWTHVECAEN 238 >UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiobacillus RepID=B5ERN5_ACIF5 Length = 262 Score = 101 bits (251), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 77/244 (31%), Positives = 114/244 (46%), Gaps = 2/244 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTRP E+++ L G FP +E + L D L L D + S+ Sbjct: 10 GIVVTRPRAQTGEMLTLLEAQGARPILFPAVEIEAPENWQSLDDALHRLVTYDWVIFSSR 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AVAFA S+L ++ WP P A+GR TA AL Q L P+ R SE LL+ PEL Sbjct: 70 NAVAFALSRLQSRNLSWPVGPRIAAVGRETAKALGEFGLQVDLVPR-RFSSEGLLESPEL 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++ G+R + G+ GREL+ TL RGA CY+R + W E+ Sbjct: 129 LDVRGQRIALFAGDQGRELLEKTLDERGAVTDEVLCYRRRLPGTNPTPLLHAWARGELDA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V VTS E+ + ++ + WL + ++ +S A+ +G +A A + Sbjct: 189 VTVTSPEIFNNFYQMV-GGLGQRWLKNTPIIAISPLTAEAVTAVGLPTPWIAPEASTAGM 247 Query: 242 LRAL 245 L AL Sbjct: 248 LAAL 251 >UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0Y9F1_9GAMM Length = 264 Score = 99.4 bits (246), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 78/259 (30%), Positives = 126/259 (48%), Gaps = 28/259 (10%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEF-----SPGQQLPQLADQLAALGESDLLF 57 +LVTRP +LV+ + T G A H P+I S + + Q AL + + Sbjct: 9 VLVTRPQGQAADLVAAIETAGGCAIHCPVIAIERLSDSDTAEQQRCKQQFMALDQFQHVI 68 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREI--- 111 +S +AV + L D+ WP+LP +++ IG +T L P + + Sbjct: 69 FISTNAVKYG---LQWIDQYWPQLPVGINWYGIGGSTTQLLRQEG-----VPVNDTVECG 120 Query: 112 ---SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA 168 SE LLQ LQ + ++ LI+RG GGR+ + L RGAEV + ECY+R + Sbjct: 121 TMNSEALLQHKGLQAFSHQKVLIVRGVGGRDYLQQVLQQRGAEVEYAECYRR-RVAVTST 179 Query: 169 EEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV--SERLAKLARELG 226 + + E+ V + SGE ++ L+ EHW + LL+V R+A++A + G Sbjct: 180 DLISKIVEYEINTVCLNSGESVENFCQLVGP---EHWSIIKGLLLVVPGARVAEIAGKKG 236 Query: 227 WQDIKVADNADNDALLRAL 245 ++ + ADNA N A++ A+ Sbjct: 237 FERVFCADNASNQAMIAAI 255 >UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PF71_CELJU Length = 277 Score = 99.0 bits (245), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/275 (29%), Positives = 126/275 (45%), Gaps = 58/275 (21%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLA--ALGESDLLFALS 60 I++TRP E +L+ G L+E P L D+ A+ + F L Sbjct: 8 IIITRPQAQAEPWAKQLQAQGFATRLLTLLEIMP------LKDETRQRAIQNRVMDFDLY 61 Query: 61 QHAVAFAQSQLHQQ----DRKWPRLP---DYFAIGRTTA--LALHTVSGQKILYPQDREI 111 Q A+ +Q+ +HQ DR WP+LP +YFA+G TTA LA+H + + + + Sbjct: 62 QKAIFVSQNAVHQAMDWLDRYWPQLPIGIEYFAVGATTARELAVHGIPVTDLAQAESGSM 121 Query: 112 -SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA-- 168 SE LL+ LQ +AG++ +I RG GGR +GD L ARGA+V +CE Y+RC + Sbjct: 122 TSEALLEAASLQQVAGEKVIIFRGLGGRGHMGDVLRARGAQVDYCELYERCLPSHAATGL 181 Query: 169 ----EEAMRWQAREVTMVVVTSGEM------------------LQQLWSLIPQWYREHWL 206 + WQAR+ M + + + LQ+ W L+P Sbjct: 182 HQLLADITCWQARQQVMALHSGESLQHLLQLLELPLLSPLRGRLQRAWLLVP-------- 233 Query: 207 LHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 SER+ A+ G+ +A+NA + A+ Sbjct: 234 --------SERIRDQAQTAGFHRCLLAENATDAAM 260 >UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WVU0_HALHL Length = 264 Score = 98.6 bits (244), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/225 (32%), Positives = 107/225 (47%), Gaps = 10/225 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP+ E LV L G W FP ++ + + +D L +SQ Sbjct: 9 GVIVTRPTHQAEGLVHALEAAGAGVWRFPTLDIIAEPEDAARQEAARRAACADWLIFVSQ 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFA----IGRTTALALHTVSGQKILYPQDREISEVLLQ 117 +AVA ++ P A +G+ TA AL +++LYP+ SE LL Sbjct: 69 NAVAHGLPRIRAAGG-----PAGHARCATVGQGTAEALRRNGIEEVLYPRHGATSEDLLA 123 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 +L I+ R +I+RG GGR + + L ARGAEV F E Y+R D A +A Sbjct: 124 ETDLGRISAGRVMIVRGVGGRPYLAEALRARGAEVDFLEVYRRVRPSTDPAPLLEAAEAD 183 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 V +VV TSGE+L L+ R WL ++V+ ER+A +A Sbjct: 184 RVQVVVATSGEVLDNFLELVGDRGR-RWLARAGVVVIGERVATMA 227 >UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15Z16_PSEA6 Length = 240 Score = 97.8 bits (242), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 77/244 (31%), Positives = 113/244 (46%), Gaps = 13/244 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFAL 59 M++L+ RP +R T G A LI Q+ L L L +L D + Sbjct: 1 MTVLIFRPEQKCAPSAARFITAGLPAVGVGLISTQASQEALSSLPSALGSLSSGDGIIVT 60 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S L QQ + P FA+G +TA L G + P +E LL L Sbjct: 61 S----TVVSQLLAQQRIELPNSATIFAVGSSTAQGLR-AQGYDVTVPL-VPTTEGLLALS 114 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 L+ IAG +IL+G GGRE + LT RGA V + YQR I A + WQA ++ Sbjct: 115 PLKEIAGHTVVILKGQGGREDLAQQLTQRGATVLLADIYQRIKIATPKATQ--EWQAEQI 172 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 ++ TSGE++ + + + WL +VVS R ++A + G + I V+D+A + Sbjct: 173 RCIIATSGEIIDTAF----EHFDAKWLQSLPWIVVSPRTEQIAVKQGIKTIFVSDDASDQ 228 Query: 240 ALLR 243 AL+R Sbjct: 229 ALIR 232 >UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteobacteria RepID=Q479S9_DECAR Length = 260 Score = 97.8 bits (242), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 4/242 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP L + G FPL+E SP L + +A L L +S Sbjct: 11 TIVVTRPQAQAAPLAEAIAAAGGKPLVFPLLEISPATDPQPLIEAVARLESYSLAVFISP 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV A + WP A+G+ TA L + P +R SE LL+LPE+ Sbjct: 71 NAVDHALPAILAHG-GWPVSLKPAAVGQGTARELAAKGVFGCVVPSERFDSEALLELPEM 129 Query: 122 --QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 +++ G+R +I RG+GGREL+ DTL RGA V CY+R WQ+ ++ Sbjct: 130 AAESVNGRRVVIFRGDGGRELLADTLRERGASVDCITCYRRSGPSAGVQPLLAAWQSGQL 189 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + V+S E L+ L + R +L L V R+A+ AR LG +I + + AD Sbjct: 190 DALTVSSSEGLRYLVDRLDAEGRA-FLQKTPLFVPHARIAENARALGLSNIILTEAADAG 248 Query: 240 AL 241 L Sbjct: 249 IL 250 >UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thauera sp. MZ1T RepID=C4ZNN4_THASP Length = 267 Score = 97.4 bits (241), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 76/248 (30%), Positives = 116/248 (46%), Gaps = 7/248 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++V RP E L +RL G A FP+I P L + L E DL F +S Sbjct: 20 TLVVMRPREQAESLCARLEAAGGRALRFPVIAVGPALDPAPLQAIVGRLDEFDLAFFVSP 79 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV A + Q R WP +G+ + + ++ PQD SE ++ LPE Sbjct: 80 NAVDHAMRAILPQ-RTWPARLRVATVGKGSQRVMQDWGFANVIAPQDGFDSEAVIALPEF 138 Query: 122 --QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G++ LI RG+GGREL+ DTL RGA V + CY+R D A E+ Sbjct: 139 AADAVRGRKVLIFRGDGGRELLADTLRERGASVEYVTCYRRHCPEADPALLLGPAARGEL 198 Query: 180 TMVVVTSGEMLQQL-WSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +++TS E ++ L W L + L + R+ AR G++ + V A + Sbjct: 199 DGLLLTSSEGVRNLEWMLGTEGL--AALHAVTVFATHPRIVAQARAAGFERV-VETPAGD 255 Query: 239 DALLRALQ 246 D L++AL+ Sbjct: 256 DGLMQALE 263 >UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomonadaceae RepID=HEM4_PSEAE Length = 251 Score = 97.1 bits (240), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 76/236 (32%), Positives = 120/236 (50%), Gaps = 17/236 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWH---FPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 +L+TRP EE + +LG+ H PL+ P ++ P+ + L + + Sbjct: 6 LLLTRPD---EECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVV 62 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S+ A A+ L + DR WP+ P + ++G TA A+ G + YP+ + SE LL Sbjct: 63 SKPA---ARLGLERLDRYWPQPPQQTWCSVGAATA-AILEAYGLDVTYPEQGDDSEALLA 118 Query: 118 LPELQN---IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 LP Q+ + + LI+RG GGRE + + L +G +V + Y+R A Y E R Sbjct: 119 LPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARV 178 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 +A + +VV+SG+ LQ L+ L + E L L V S R+A++ARELG Q + Sbjct: 179 RAERLNGLVVSSGQGLQNLYQLAAADWPEIGRLP--LFVPSPRVAEMARELGAQRV 232 >UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marinobacter RepID=A1TXW8_MARAV Length = 270 Score = 96.7 bits (239), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 117/244 (47%), Gaps = 11/244 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+ RP P L R G A P++ P + P+ L L + A+S + Sbjct: 19 VLICRPEPEASRLAEAFRKAGADARVMPMMAREPLPETPEQRGILQQLDNFSHIIAVSPY 78 Query: 63 AVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 A A+ + + D WP+LP ++ +G TA A+ G K P + SE LL LP Sbjct: 79 A---ARRLMEEIDHWWPQLPAGLQWYGVGAGTA-AVFREHGLKPRMPAEGWTSEALLALP 134 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 LQ + G++ L+ RG GRELI +TL RGA +T Y+R +Y + Sbjct: 135 SLQRVDGEKVLLARGEHGRELIRETLAQRGARITTLPLYRRVLPYYSAKQVKALVADFHP 194 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV-SERLAKLARELGWQDIKVADNADN 238 +V+ SGE L L L +R L ++VV +ER+A+ AR LG++ V + ++ Sbjct: 195 EVVIALSGETLNNLVEL---GHRYQLALTPDIIVVPAERVAEQARALGFRKPLVPGSLND 251 Query: 239 DALL 242 D L+ Sbjct: 252 DDLV 255 >UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BLH7_TERTT Length = 266 Score = 96.3 bits (238), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 23/256 (8%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS----PGQQLPQLADQLAALGESDLLFA 58 IL +RP S+L+ G PL+ + P QQ + + + D + Sbjct: 9 ILASRPLAQNSSWSSKLQAAGYRVLALPLLAIAQVQEPAQQ-QSIKNCILDFDHYDAVIF 67 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPD---YFAIG-RTTALALHTVSGQKILYPQDREI-SE 113 +SQ+AV ++ D+ WP+LP Y+A+G +T A H + + ++ + +E Sbjct: 68 VSQNAV---EATWQWLDQYWPQLPQGITYYAVGIKTAAQVQHFLGSEATVHAALTAMNTE 124 Query: 114 VLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 LL LP LQ +A +R LI RG GGR +GD L RGA VT+CE YQR AE + Sbjct: 125 ELLALPGLQQVAHQRILICRGLGGRPRLGDELENRGAAVTYCELYQRTL----PAEAVTQ 180 Query: 174 WQAREVT----MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD 229 + + ++ V SGE LQ L + + L L+V ER+A LA E G+Q Sbjct: 181 FTDANLNPAQDVLCVFSGETLQNLLYVATTAGAD--LSAFALVVPGERVAALAAEQGFQQ 238 Query: 230 IKVADNADNDALLRAL 245 I++A NA A+L A+ Sbjct: 239 IQIARNAGEAAMLAAI 254 >UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggiatoa sp. PS RepID=A7BY77_9GAMM Length = 271 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 126/269 (46%), Gaps = 33/269 (12%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + ILVTRP+ E L + G + P+IE + L D L E D+ +S Sbjct: 6 IKILVTRPAHQAEHLCQLIEAEGGQSIRLPVIEIIDIEDKTALFDCRMHLDELDIAIFIS 65 Query: 61 QHAVAFAQSQL----HQQDRKWPRLP------DYF----------AIGRTTALALHTVSG 100 +AV + L H ++ K P YF A+G+ T L G Sbjct: 66 ANAVDKSLPTLLTPNHSENEKDSLTPVSTNSTTYFQREEQTLQIIAVGKRTTSTLKA-WG 124 Query: 101 QKILYPQDREISEVLLQLPELQN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECY 158 L P SE +L++P++Q + GK+ +I RG GGREL+ +TL RGA V + Y Sbjct: 125 LTALCPDSPFNSEAVLKMPQMQTEVVQGKKIVIFRGEGGRELLAETLQQRGAIVNYINVY 184 Query: 159 QRCAIHYDGAEEAMRWQAR-EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSER 217 +R +W A V ++ VTS E LQ L++++ + WL H +V+SER Sbjct: 185 RRI------QPSVPKWIADISVDVITVTSIEGLQNLFAMLEKQV--AWLCHTPFVVMSER 236 Query: 218 LAKLARELGWQ-DIKVADNADNDALLRAL 245 + A++LG Q I VA A +D LL A+ Sbjct: 237 IRTEAQKLGVQAPIFVAPTASDDGLLTAI 265 >UniRef50_UPI0001BC6E7F uroporphyrinogen-III synthase, putative n=1 Tax=Buchnera aphidicola str. LSR1 (Acyrthosiphon pisum) RepID=UPI0001BC6E7F Length = 137 Score = 95.1 bits (235), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 42/131 (32%), Positives = 76/131 (58%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 +++ I R ++L+G GR+LI L G ++ ECY+R D E +W+ Sbjct: 1 MKIINKDKIKNNRIILLQGENGRKLIKRRLEKEGFKICLIECYKRVFKILDTNMEVKKWR 60 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + ++ +VVT+ E L QL ++I + WL CR+ VV +RL ++A++LGW D+ V+ Sbjct: 61 SYKIDTLVVTNSESLHQLKNIISSTNQIQWLFGCRIFVVGKRLFRIAKKLGWNDVIVSKY 120 Query: 236 ADNDALLRALQ 246 A+ND+ ++ ++ Sbjct: 121 ANNDSFIKRIK 131 >UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina loihiensis RepID=Q5QUS2_IDILO Length = 251 Score = 92.4 bits (228), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 76/247 (30%), Positives = 118/247 (47%), Gaps = 14/247 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 ++L+ RP + ++ +LR G+ + IE P LP +QL + + D + + Sbjct: 8 AVLLLRPGKSPDDFTQQLRKTGRECFVHSFIEIEP---LPVNKEQLTQIKQKHWDGIVIV 64 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPD-YFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 S++A +A + +P Y+A+G TA + P SE LL+L Sbjct: 65 SKNAAHYASRA------GFSGVPSKYYAVGPGTASFACKHLNTAVSCPAFIHQSEGLLEL 118 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 ELQ + + LI+RG GGREL+ D + ARGA V + E Y+R + + E +W Sbjct: 119 SELQKLQQQNWLIIRGEGGRELLADAIRARGASVDYWEVYRRKQLTLNDPELIQQW-ISS 177 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V +VVTS E L S +P + WL C+ +V S RL L +IKV +A + Sbjct: 178 VGTIVVTSAEQLGYFLSSMPN-SAQSWLDSCQWIVPSHRLKGLIPFGQSDNIKVTGSAAD 236 Query: 239 DALLRAL 245 L+ AL Sbjct: 237 AILMNAL 243 >UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RC73_LEGLO Length = 252 Score = 90.1 bits (222), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/232 (29%), Positives = 107/232 (46%), Gaps = 4/232 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP +L +R G +A P +E D L L +S Sbjct: 8 LRILNTRPQEQAHKLTESIRASGGIAIELPALEIQASNS--DWVDLLPNLDNVTHAIFIS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +QL+Q WP AIG+ TA +L + Q P+ SE LL L Sbjct: 66 ANAVHYCFTQLNQLQINWPTSIQVIAIGQGTASSLQKFNIQVSAIPEFPN-SEHLLSLDT 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ + L+ +G GR LI + L +GA++ + YQR W+ V Sbjct: 125 LQHLENQNVLLFKGKEGRPLIEEQLMQKGAKLVILKVYQRVMPKPSPLLVQSIWRDDLVD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 ++++TS + L L+ + + + WL R LV+SER+A++A LG I + Sbjct: 185 IILLTSEQSLLNLFKIFDKEAHD-WLKSKRWLVISERIAQIASSLGIHKINI 235 >UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z3B7_9GAMM Length = 660 Score = 89.7 bits (221), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 77/246 (31%), Positives = 124/246 (50%), Gaps = 8/246 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ ++TRP E L L G + PLI + + +L L D+ +S Sbjct: 3 LTAVLTRPGGVVEPLQLVLEQRGVDTFVQPLINIA---SISVEHRELITLYPGDICIFIS 59 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV S L Q R+ P A+GR TA A+ + +G + P + SE LL L Sbjct: 60 VNAVEQGLSNLAPQLREL-GCP-ILAVGRATASAI-SAAGFDVSVPSQAD-SEGLLGLDI 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + GK+ +I++G GGR L+ + L RGA+V CY+R D + + RE Sbjct: 116 LHGVKGKQVVIVKGEGGRGLLAEALRERGADVVSYVCYRRDPTGIDAGQFCWQLCEREHV 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + +SGE+++QL L+ Q + + LL ++V S R+AK+A LGW ++ A A +D+ Sbjct: 176 VFQASSGEIVEQLTELLGQGGQPN-LLDSPVIVPSGRVAKIAVGLGWTNVITAAGAGDDS 234 Query: 241 LLRALQ 246 L A++ Sbjct: 235 FLSAIE 240 >UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marinomonas sp. MWYL1 RepID=A6W1B5_MARMS Length = 250 Score = 89.4 bits (220), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 70/254 (27%), Positives = 119/254 (46%), Gaps = 24/254 (9%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLAD---QLAALGESDLLFAL 59 IL+TRP P R+R G VA P++E P + + + A Q+ + D + + Sbjct: 6 ILITRPEPENSLSRERVRAYGWVAVPLPMLEIKPVEDVNKKATIRAQIFDIDTFDYVIFV 65 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 S++A A L D WP +P + IG+ T L I P +E LL Sbjct: 66 SKNAARLACDWL---DECWPMIPTNVHWIGIGQGTTQTLLNEGIPAISNPG--HTTETLL 120 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + + + ++ LI+RG GGR + + L RGA+V++ Y R Y M Sbjct: 121 EWLKPAKMKDQKVLIIRGEGGRPELANKLEERGAKVSYLSLYDRKKPIYYAQTFFM---L 177 Query: 177 REVTMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 ++ ++ +TSGE L+ L + P+W +L S R+ + A+E+GW + Sbjct: 178 PDINLIWITSGESLRNLSEYVSLHKPEWKT------LPILTPSIRVNQQAKEMGWINASC 231 Query: 233 ADNADNDALLRALQ 246 A+ AD+++L++A + Sbjct: 232 ANGADDNSLIKATE 245 >UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=2 Tax=Alteromonadales RepID=Q3IF71_PSEHT Length = 616 Score = 89.4 bits (220), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/253 (28%), Positives = 122/253 (48%), Gaps = 23/253 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++IL+TRP G L +L G A FP+++ + L + +L+ L +D + +S Sbjct: 2 LNILITRPQGKGAALAQQLEQAGYQASLFPVLKI---EYLTPDSIELSPLTNADKIIFVS 58 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD------YFAIGRTTALALHTVSGQKILYPQDREISEV 114 Q AV A S+L PD ++ +G+ TA ++ V G + P+ + SE Sbjct: 59 QDAV-LALSELK---------PDINIKAQFYGVGQQTADTIYEVFGVRAAVPKQHD-SEG 107 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 LL L L ++ ++++G GGR I TL RGA + C YQR I + W Sbjct: 108 LLALKSLADVDSCNIVLVKGIGGRPDIAKTLKQRGAFLNNCVVYQRTPIDPEPNNWIDHW 167 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAR--ELGWQDIKV 232 Q++ V +V+TS + ++ + R+ WL CR V SER+ + ++ +I + Sbjct: 168 QSQNVHGIVITSNAAVDAIFKNLAAPQRQ-WLQQCRFYVASERIGAYLQQHQVSSANIHI 226 Query: 233 ADNADNDALLRAL 245 A A ++A+ + Sbjct: 227 AAGASDNAMFTCI 239 >UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Saccharophagus degradans 2-40 RepID=Q21EF8_SACD2 Length = 290 Score = 89.0 bits (219), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 83/278 (29%), Positives = 125/278 (44%), Gaps = 39/278 (14%) Query: 1 MSILVTRPSPAGEELVSRLRTLG-QVAWH---FPLIEFSP--GQ-QLPQLADQLAALGES 53 + I+ +RP E R+ + W PL+E P G+ + QL Q L + Sbjct: 8 IRIIASRPVAQNSEWCKRIEMFNSEAVWRALPIPLLEIIPVTGEAEKRQLQTQALGLDDY 67 Query: 54 DLLFALSQHAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALAL-------HTVSGQKI 103 + +SQ+AV + L + WP+LP + +G T A+ Q + Sbjct: 68 QKILFVSQNAVEHFFTCL---EDYWPQLPKQLCFIGVGEKTKQAILQQLDRWGCAGDQIV 124 Query: 104 LYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI 163 L D SE LL +PELQ + ++ LI RG GGR ++G+ L ARGA + +CE YQR Sbjct: 125 LGGVDAMNSEALLAMPELQQVDAEKILICRGVGGRPMLGEILVARGARIEYCELYQRALP 184 Query: 164 HYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLI------------PQWYREHWLLHCRL 211 A A + V SGE L L +++ P W R Sbjct: 185 KQAVAVLAEADLNSTTDICPVFSGETLTNLVAVLAKHSNPRASEKPPFRLPAQW----RA 240 Query: 212 LVV---SERLAKLARELGWQDIKVADNADNDALLRALQ 246 L+V ER+A+ A+ +G++ I VA NA A+L+A+Q Sbjct: 241 LIVVVPGERVAQHAKAVGFKRIAVAKNATEPAMLKAIQ 278 >UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina baltica OS145 RepID=A3WKE6_9GAMM Length = 241 Score = 88.6 bits (218), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/191 (34%), Positives = 94/191 (49%), Gaps = 14/191 (7%) Query: 59 LSQHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +S++AV FA D + LP FA+G TTA G P + SE LL Sbjct: 57 ISKNAVKFAA------DAGFRFLPQTSMFAVGPTTARLAANTFGISAYCPTYKHDSESLL 110 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LPE+ N+ ++ LI++G GR+L+ DTL ARGA V+ + Y+R + + +W Sbjct: 111 TLPEMVNVDNQKWLIIKGEKGRDLLFDTLRARGATVSSIDVYRRVKRPLNDETQVTQWM- 169 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREH--WLLHCRLLVVSERLAKLARELGWQDIKVAD 234 V ++VVTS E L S +P RE WL C +V SERL L + I V Sbjct: 170 NTVNLIVVTSAEQLGYFLSSLP---REAGGWLSRCDWIVPSERLRDLIPFVAADTITVTG 226 Query: 235 NADNDALLRAL 245 +A ++ A+ Sbjct: 227 SATESKMIEAI 237 >UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Tax=Glaciecola sp. HTCC2999 RepID=UPI0000E105B4 Length = 249 Score = 88.6 bits (218), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 57/181 (31%), Positives = 97/181 (53%), Gaps = 23/181 (12%) Query: 79 PRLPD------YFAIGRTTALALHTVSGQKILYPQDREI---------SEVLLQLPELQN 123 P +PD +A+G++T L + Q + + ++ SE +L LP L + Sbjct: 67 PFMPDLSSHTYVYAVGKSTFQTLAQWTHQYPFWCNNHQLMMPLAHQQTSEGILSLPSLSD 126 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + +R +I++G GGRE + DTL+ RGA V+ C Y+R ++ + +A WQ ++T + Sbjct: 127 VTEQRIVIVKGLGGRETLRDTLSERGAVVSECTVYERITLNNPVSTQA--WQVTDITGIT 184 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW--QDIKVADNADNDAL 241 TS E LQ + + P WL + +VVS R+A+ A +LG Q I ++ +AD+ AL Sbjct: 185 ATSNEQLQLAFDIYPH----SWLTELKWVVVSPRIAQYALKLGIPNQQISISQSADDAAL 240 Query: 242 L 242 + Sbjct: 241 I 241 >UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsiella grylli RepID=A8PKZ2_9COXI Length = 262 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/247 (28%), Positives = 119/247 (48%), Gaps = 7/247 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP EL ++++ G HFP +E + + ++ +L L + +S Sbjct: 7 LRVLITRPLHQTSELTTQIQNCGGFVVHFPTLEINQVPNIKKINSELKKLNHYHFVIFIS 66 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++V +H WP A G T AL +P+ ++ L Sbjct: 67 PNSVFNTAPSIHAIWPHWPCSTKTIATGLGTVSALKQHHLPSHFHPEKNYTGMGIINLSI 126 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I GK+ LI++G GGR + L RGA V Y+R E+ ++ Sbjct: 127 LQTIKGKKILIIKGQGGRLNLIKNLKTRGASVNNLVVYKR---QLPAIEKQCIPNQEDID 183 Query: 181 MVVVTSGEMLQQLWSLI-PQWYREHWLLHCRLLVVSERLAKLARELGWQDIK-VADNADN 238 +++ TSG L+ L +L+ P+W E L ++LV+S RLA +A++LG+ + +ADNA + Sbjct: 184 VIICTSGTGLKNLVTLLHPRW--ESHLFKKQMLVISPRLAVIAKKLGFVKLPLIADNASH 241 Query: 239 DALLRAL 245 DA+L L Sbjct: 242 DAILHTL 248 >UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococcus oceani RepID=Q3JDS0_NITOC Length = 265 Score = 86.7 bits (213), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 76/251 (30%), Positives = 116/251 (46%), Gaps = 17/251 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ E+L + G A FP +E ++P + +++ +G D H Sbjct: 17 VLVTRPAEQAEKLSQAIELEGGQAVRFPTVEIG-DSEVPAVVEEI--IGRLDDF-----H 68 Query: 63 AVAFAQSQLHQQDRKW-------PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVL 115 F + Q+ W P +GR TA AL L P SE L Sbjct: 69 WAVFVSANAVQRGVPWVFARREMPANLKIAVVGRATAQALGNFGLYPRLCPSYGYNSEAL 128 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD-GAEEAMRW 174 L + ELQ++ G++ ++ R +GGREL+ TLT RGA+V + E Y+RC A Sbjct: 129 LAMDELQDMKGQQVVLFRASGGRELLAKTLTKRGAKVEYAEVYRRCLPSPSVAANLRQVL 188 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 V +V+ TS +L+ L L + E L L+V+ R + ARELG+ I VA Sbjct: 189 VNVPVDVVITTSKAVLENLCHLAGEPLLEK-LRRTPLVVIGSRQVQQARELGFTQIWVAQ 247 Query: 235 NADNDALLRAL 245 + AL++ + Sbjct: 248 EPSDAALVQTI 258 >UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A578_ALHEH Length = 261 Score = 86.3 bits (212), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 8/249 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP+ L L G W P +E P + A +AALGE+D L +S Sbjct: 8 GVLVTRPAHQAAGLCRTLEAAGARVWALPTLEIVPQPESALPAAAVAALGEADWLIFVSP 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + + + + PR PD A+G+ T ALH V PQ SE L + P Sbjct: 68 NAVHHGLACMARHGVR-PR-PDARIAAVGKGTERALHRVGLSVTAVPQAGFTSEDLAREP 125 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ G+R +I+RG+ GR + + L +GAEV F Y+ D QA + Sbjct: 126 AFGDMRGQRVMIVRGDSGRAWLAEHLRGQGAEVAFLAVYRAVRPQVDAQPVVEALQAGRL 185 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLV-VSERLAKLARELGWQD-IKVADNAD 237 V++TS L LW ++ R L+ R LV VS R+A+ A + G + VA + Sbjct: 186 HSVIITSVRGLDNLWFMLGDSGR--VLVQRRALVTVSPRIARYAEQAGHTGPVVVARSPA 243 Query: 238 NDALLRALQ 246 ++ LL+A+ Sbjct: 244 DEDLLQAVH 252 >UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepID=C1D9V4_LARHH Length = 248 Score = 85.9 bits (211), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/193 (33%), Positives = 91/193 (47%), Gaps = 14/193 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQL-AALGESDLLFALSQ 61 +++TRP AG L + LRT G + +PL+ P P+ D+L AAL +D L +S Sbjct: 6 VIITRPHEAGAPLAAALRTAGFAPFEWPLLALEPE---PEALDRLPAALAGADWLVVVSP 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYF---AIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 A L RLP A+GR TA L SG+ +LYP SE LL L Sbjct: 63 SAARLIAPALA-------RLPAGLRLAAVGRATAQVLEQASGRPVLYPATGNDSEALLAL 115 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 P+ + G+ +I +G+GGR + + L RGA V Y+R + D A Sbjct: 116 PDWGALDGRTVVIAKGHGGRPWLAENLARRGARVVPLALYRRRKLTPDPAALQAALAVHP 175 Query: 179 VTMVVVTSGEMLQ 191 V+VTS E+ + Sbjct: 176 QAAVLVTSTEIAE 188 >UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456_AZOSB Length = 265 Score = 84.3 bits (207), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/247 (28%), Positives = 112/247 (45%), Gaps = 9/247 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + VTRP L +R G FP++ + L + +A L DL F +S + Sbjct: 19 VAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPN 78 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV A + + + R WP + +G+ + AL ++ P + SE +L LP Sbjct: 79 AVEHALAAVKAR-RHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFS 137 Query: 123 NIA--GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 A G+R +I RG+GGREL+ D L ARGA V CY+R D A + Sbjct: 138 ATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLD 197 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVS--ERLAKLARELGWQDIKVADNADN 238 +V+TS E ++ L ++ + + + + R+ V + R+ AR G+ ++ D Sbjct: 198 ALVLTSSEGVRNLVEMVGE---KGFGVLRRVTVFAPHPRIVAHARAAGFDRVEETPPGD- 253 Query: 239 DALLRAL 245 D LL L Sbjct: 254 DGLLETL 260 >UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=2 Tax=Oxalobacteraceae RepID=A4G3V3_HERAR Length = 260 Score = 84.0 bits (206), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 87/268 (32%), Positives = 125/268 (46%), Gaps = 43/268 (16%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TRP E L R+ LG+ A FPL++ P LADQ A+L ++ L LS + Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILP------LADQ-ASLQQA--LRDLSGY 59 Query: 63 A-VAFAQSQLHQQDR----KWPRLPDYFAIGRTTALALH----TVSGQKILYPQD--REI 111 A +AF WPR +G + LAL T I+ P D R Sbjct: 60 ALIAFVSPNAIDAALAARADWPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTD 119 Query: 112 SEVLL---QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA 168 SE LL LP L+N K+ LI+RG GR L+ + L A GA+VT Y+R A +D Sbjct: 120 SETLLAELDLPALRN---KQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDAT 176 Query: 169 EEAMRWQAREVTMV-------VVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERL 218 RE+ + +VTS E L+ L ++ Q + R++V R+ Sbjct: 177 RR------RELKRLLHGQNDWIVTSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRI 230 Query: 219 AKLARELGWQDIKVADNADNDALLRALQ 246 + A+ LG+ +I V + D D LL ALQ Sbjct: 231 GETAQLLGFSNITVTRSGD-DGLLAALQ 257 >UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z5H2_9NEIS Length = 245 Score = 84.0 bits (206), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 82/251 (32%), Positives = 119/251 (47%), Gaps = 27/251 (10%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ----LPQLADQLAALGESDLLFA 58 ILVTRP L++ L G P+++ P ++ LP LA+ +D L Sbjct: 8 ILVTRPPAQSARLMALLSDAGAEPLPLPVLDIVPDERALAALPTLAEA------ADWLIF 61 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S A+ A L ++ K +G +A L +SG+ +L+P+D S LL L Sbjct: 62 VSPSAIDAAWPVLARRKLKA----RLACVGAASAAKLAALSGRAVLHPRDGSDSAALLAL 117 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 PELQ + G+R LI+RG GGR +G+TL ARGA +T E Y+R DG + W E Sbjct: 118 PELQRLTGQRVLIVRGVGGRAELGETLAARGARLTLAEVYRR----VDGEPD---WSLLE 170 Query: 179 --VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSE-RLAKLARELGWQDIKVADN 235 V +V+TS + ++L+ L L C L V R+A G I V Sbjct: 171 QPVDALVLTSSDTAERLFRL--AGRSRSLTLQCLLYCVPHPRIAATLAAHGVTRI-VTTQ 227 Query: 236 ADNDALLRALQ 246 AD+ AL+ L Sbjct: 228 ADDAALVAGLS 238 >UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N2Y5_9GAMM Length = 250 Score = 84.0 bits (206), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 74/245 (30%), Positives = 121/245 (49%), Gaps = 13/245 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLA-ALGESDLLFALSQ 61 IL+TRP ++L + G FP+I +P LP Q A L ++ L +S+ Sbjct: 12 ILITRPRQQSDQLAELIEQAGGKPILFPVIAINP--LLPSDWQQPAFKLDHANWLIFVSR 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKI-LYPQDREISEVLLQLPE 120 +AV S + P+ + A+G TA A+ SG K+ P+ SE LL +PE Sbjct: 70 NAVLSFMSGWQTE---LPKHLKFAAVGGGTAQAMRE-SGLKVDCQPEISSGSEGLLMMPE 125 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q++A + +I+RG GGRE + DTL +RGA +++ E Y+R D A ++ Sbjct: 126 MQDVADCKIIIIRGVGGREHLADTLASRGASISYMEVYRRDVAVQDKVSIERAMAADKLI 185 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V + + Q+ S LL+ L+VVS R+ A G+ ++V+ +A + A Sbjct: 186 CTSVAGIDNVCQILS-----DDMTNLLNKPLVVVSNRIKAHAESKGFSCVRVSTDASDVA 240 Query: 241 LLRAL 245 +L+ L Sbjct: 241 MLQTL 245 >UniRef50_UPI0001BC6E7E uroporphyrinogen-III synthase n=1 Tax=Buchnera aphidicola str. LSR1 (Acyrthosiphon pisum) RepID=UPI0001BC6E7E Length = 115 Score = 82.0 bits (201), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 37/95 (38%), Positives = 54/95 (56%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ILV RPSP GEELV L +G +WHF L +F P L+ ++ L +S ++ S Sbjct: 1 MKILVIRPSPTGEELVYNLNKIGISSWHFSLFDFYPSFSPISLSKKINELYQSKVILVFS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALAL 95 + A+ + L + +WP Y+AIG++TAL L Sbjct: 61 KKAIYYTNLYLKSNNLQWPLHAKYYAIGKSTALFL 95 >UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N607_9GAMM Length = 251 Score = 80.9 bits (198), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 101/230 (43%), Gaps = 5/230 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L TRP E L + +R V P + + P L L + D +S Sbjct: 8 LRVLNTRPQGQAELLSNAIRAADGVVLELPTLAI---EATPDWLSTLPDLKKVDQAIFVS 64 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV +QL Q +WP AIG+ A AL + P+ + SE LL L Sbjct: 65 ANAVEQCFTQLQQAGFRWPATIRVIAIGQGCAAALKKFNIPIHAMPEIAD-SEHLLTLSS 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + LI +G GGR LI +TL +G + YQR + W+ V Sbjct: 124 LLQPQKQNILIFKGAGGRALIEETLLNKGVNLLALNVYQRVMPKINHQFVKSIWRDDLVD 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 ++++TS + + L+ L + HWL LV+SERLA++A LG I Sbjct: 184 IILLTSEQSMHHLFKLFEK-DAHHWLRQKTCLVISERLAQIASSLGMSTI 232 >UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta proteobacterium KB13 RepID=B6BVM6_9PROT Length = 247 Score = 79.3 bits (194), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/193 (27%), Positives = 91/193 (47%), Gaps = 4/193 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALG-ESDLLFALS 60 +++ TR S + +++ + +P IE P P++ + + S ++F S Sbjct: 3 NLIATRSSLQNQSIINFFKGSSLNVIDYPFIEIEPIFSTPEIKKIIDDMHLFSKIIFISS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A F H K+ FAIG TT L + + I P D+ S+ LL+LPE Sbjct: 63 NAAQCFKIISEHHS-IKFSDNVQIFAIGPTTKKEL-SFLKKNIFSPIDQFDSKTLLELPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +QN+ + LI+RG GG+EL+ + L + A + + ECYQR D + +E Sbjct: 121 IQNVKDESILIVRGVGGKELLKNELEKKQANIAYLECYQRIFKLID-FNIITNYSQKETL 179 Query: 181 MVVVTSGEMLQQL 193 +++TS ++ Q Sbjct: 180 YILITSSQIAQHF 192 >UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SQ71_HAHCH Length = 260 Score = 75.9 bits (185), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 80/255 (31%), Positives = 120/255 (47%), Gaps = 18/255 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP + L + L P I P + + D + L + +S Sbjct: 12 LRVLLTRPQGENDSLRALLEQNSAEVRVLPAIAIEPLPETQAIKDCILDLDRYTHVICVS 71 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 +HA ++ L D WP+ P +FAIG ++A L + G + P+ SE LL+ Sbjct: 72 KHA---SRLLLELIDAYWPQAPQGVRWFAIGESSAAPLRSY-GLTVNTPEQGCASEQLLE 127 Query: 118 LPELQ----NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE--EA 171 P LQ + R LI++G GGREL+ +T+ RGA V E Y+R + YD E EA Sbjct: 128 HPGLQARNEDEPPMRVLIVKGCGGRELLTETMQERGAHVATLELYERKTLEYDPNELNEA 187 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 ++ EV VV SGE L L L Q W ++ S R+A LA+E + K Sbjct: 188 LKQWRPEV--VVTLSGETLLHLCQL-GQNIGYAW-GDTLFVIPSARVATLAQE-NRLNYK 242 Query: 232 VADNADNDALLRALQ 246 +A ++ALL L+ Sbjct: 243 IAPELSDEALLALLK 257 >UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella burnetii RepID=A9KDC7_COXBN Length = 268 Score = 74.7 bits (182), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/265 (27%), Positives = 113/265 (42%), Gaps = 31/265 (11%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLI----------------EFSPGQQLPQLAD 45 +I++TRP GE L + G FP + F P ++ D Sbjct: 10 TIMITRPEGQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDD 69 Query: 46 QLAALG---ESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK 102 ++ G SD+L LS +AV + + ++K AIG TA AL G Sbjct: 70 KMTKAGFLNSSDILIFLSANAVKHSPILNFKAEQKL------VAIGTGTAAALFQ-RGLS 122 Query: 103 ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR-C 161 + + SE LL LP L + GK I G R + + L RGA V Y+R Sbjct: 123 VDAVPEHFSSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYRRER 182 Query: 162 AIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKL 221 + +A+ Q + +V TS E LQ L +L +HWL L+V+S+R+ L Sbjct: 183 PVVNKKTIDALTHQT--LHAIVSTSAESLQNLCTLFES--HQHWLHRIPLVVISKRMENL 238 Query: 222 ARELGWQDIKVADNADNDALLRALQ 246 A+ G+ + +ADN A+++ L Sbjct: 239 AKSQGFHLVLLADNPGEKAIIKVLS 263 >UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionella pneumophila RepID=Q5X1F1_LEGPA Length = 250 Score = 72.8 bits (177), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 108/233 (46%), Gaps = 4/233 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP + L ++ G + P +E + + L L + +S Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASEN--NWINNLPDLTSVNQAIFVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +L ++ W AIG+ T+ L+ + Q P+ + SE LL L Sbjct: 66 ANAVRYFMMELASKNINWLNSIRVAAIGKGTSRVLNEFNIQVSDVPELPD-SEHLLTLNS 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I + L+++G GGR+LI + L +GA++ Y+R D W+ Sbjct: 125 LQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDQEFLNSLWRDDLAD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 ++++TS + + L+ + + WL + LV+S+RLAK+A G + I ++ Sbjct: 185 IILLTSEQSIHNLFKMF-SIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236 >UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfur-oxidizing symbionts RepID=A1AXB3_RUTMC Length = 248 Score = 72.8 bits (177), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/250 (24%), Positives = 109/250 (43%), Gaps = 20/250 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++L+TRP EEL S + G FP ++ + D D++ +S Sbjct: 1 MNVLLTRPLLQVEELQSMVTKSGNKPLLFPTLKLNS-------IDAKVENNYYDVIIFIS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L K FA+G TA L + +P+ + SE LL L Sbjct: 54 VNAVEYGLKIL-----KTISYHKIFAVGSATARKLSENDIEIDDFPRKKASSEALLALDS 108 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRC-----AIHYDGAEEAMRWQ 175 + + K LI RG GRE++ L + +V + E Y+R ++H +E + Sbjct: 109 VAQLYHKTILIFRGQSGREVLKQGLIKQNNQVEYVEVYERVNHNINSLHRQSLDELL--- 165 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +R ++ +TS + ++ L + Q L + L+V+S+R+ +G+ + V N Sbjct: 166 SRNEGVISITSIDSMKLLVKISSQILDVDRLKNYLLVVLSDRIKTYVNSIGFNKVLVTPN 225 Query: 236 ADNDALLRAL 245 N+ ++ L Sbjct: 226 TSNNGIISVL 235 >UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivorax RepID=Q0VM29_ALCBS Length = 243 Score = 72.4 bits (176), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 105/243 (43%), Gaps = 16/243 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP + L+ L G H P + P + L L +F S + Sbjct: 10 VVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASVN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A A S + +WP + A+GR TA L + + PQ +E +L LP LQ Sbjct: 70 AARLALSAMADLWPQWPVGVHWLAVGRATAAELESWHLPATV-PQQGFNTEAVLALPCLQ 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + K+ LI RG+ GREL+ TL +RGA V Y+R A W V Sbjct: 129 QLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKAASPVLIPAETDW-------V 181 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 ++TS + Q + +P C ++ ER+A + R D+ VA +A ++ +L Sbjct: 182 MITSVQGWQAIGGSVPPC--------CGVVAAGERVADVVRAEHSGDVSVAASAHDEDML 233 Query: 243 RAL 245 AL Sbjct: 234 SAL 236 >UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burkholderia RepID=Q143B4_BURXL Length = 672 Score = 72.0 bits (175), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 115/269 (42%), Gaps = 47/269 (17%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++TRP+ EL++RL G FPLI+ +P L L++L L+ +S Sbjct: 18 FTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVS 77 Query: 61 QHAVAFAQSQLHQQDRKWPR-LP-DYFAIGRTTALALHTVSGQ--KILYP---QDREI-- 111 +AV +A + D WP LP G ALA H V+ ++ P D E Sbjct: 78 PNAVDYA---FARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETAR 134 Query: 112 --SEVLLQLPEL----QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA--- 162 SE L + N+ GKR LI+RG+GGRE + + L GAEV Y+R Sbjct: 135 FDSEGLFAAIDTALGATNLEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEP 194 Query: 163 -------IHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW-------LLH 208 +H A W ++TS E ++ L L ++H L Sbjct: 195 SIGGWARVHELLAGAPHAW--------LLTSSEGVRNLHEL----AQDHLTADEISQLKR 242 Query: 209 CRLLVVSERLAKLARELGWQDIKVADNAD 237 L+ R+A+ AR LG+ I V+ D Sbjct: 243 AALVTPHPRIAQTARALGFDSITVSGAGD 271 >UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JT00_9GAMM Length = 618 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/251 (28%), Positives = 110/251 (43%), Gaps = 19/251 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TR + + L++ + G + ++ P + AAL + +S Sbjct: 8 LRVLITRTAKQAKPLLTLIEAEGGMGTPAGVLSIEADYGDPSVTAAKAALDQYHRFIFVS 67 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 +AV + L LPD +GR T L P+ SE LL Sbjct: 68 ANAVEHGLAALGS-------LPDEARLACVGRKTRQTLEQAGYSVADCPESDFNSEALLA 120 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD--GAEEAMRWQ 175 LP LQN+ G+R LI+RG+GGR+LI DTL RGA+V ECY R D ++A+ Sbjct: 121 LPSLQNVDGERILIVRGHGGRQLIRDTLQQRGAQVDSVECYHRQLSDGDFRPLQDAIESG 180 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI-KVAD 234 A +V + L Q L L+ VS + ARELG+ I +A Sbjct: 181 AFDVICPSSSESLALLS------QACPSKSLKSLPLIAVSATMQDKARELGFTQIAAMAK 234 Query: 235 NADNDALLRAL 245 +A ++++ AL Sbjct: 235 DATDESIFDAL 245 >UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D4B Length = 247 Score = 70.5 bits (171), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 9/221 (4%) Query: 29 FPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIG 88 FPL E P ++ + L L L +S +AV F ++++ P IG Sbjct: 31 FPLTEILPLKEYEEFDLILQNLSSYHHLIFISTNAVDFFVARMNFYHITLPSSLIISCIG 90 Query: 89 RTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTAR 148 +T L + YP++ SE LL+ +I ++ LI+RG GGRE + L + Sbjct: 91 PSTKKLLQENFNTPVFYPRESFDSEHLLKSDIFSDIKNQKILIIRGIGGRETLRKGLEKK 150 Query: 149 GAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH--WL 206 G +T+ ECY R + D E +++TS E ++ +H WL Sbjct: 151 GGLITYGECYTRKYLQIDLEEVRKSTYEFNRIFMLITSYESAKKFMQ---HNITDHLGWL 207 Query: 207 LHCRLLVVSERLAKLARELG-WQDIKVADNADNDALLRALQ 246 ++V R L EL + +I + ++ ND++LR L+ Sbjct: 208 KSIHVIVNHIR---LKNELNIFSNITITEDLSNDSILRILK 245 >UniRef50_B4SRW6 Uroporphyrinogen III synthase HEM4 n=4 Tax=Xanthomonadaceae RepID=B4SRW6_STRM5 Length = 269 Score = 69.7 bits (169), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 48/148 (32%), Positives = 72/148 (48%), Gaps = 1/148 (0%) Query: 84 YFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGD 143 + +G TA AL ++ PQ R SE LL LP L ++ G+R ++ GGR LI Sbjct: 99 WLTVGEGTARALRAQGVHEVHAPQ-RMDSEGLLALPVLADVRGRRIGLVTAPGGRGLIAA 157 Query: 144 TLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE 203 L A GA + + YQR + A + ++ V+SGE LQ W +P ++ Sbjct: 158 QLQAAGASIERADVYQRRPLRLSPRTLARLAHSAYPWVLAVSSGEALQHFWRQLPHALQQ 217 Query: 204 HWLLHCRLLVVSERLAKLARELGWQDIK 231 H ++V S+RL + A+ LG Q I Sbjct: 218 RLQAHASVVVASDRLREQAQALGLQRIS 245 >UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7R6S2_KANKD Length = 250 Score = 68.2 bits (165), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 111/253 (43%), Gaps = 25/253 (9%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRPSP GE L L G A H PLI F+ QL L + L +S+ Sbjct: 6 TIIVTRPSPMGESLCQELNDEGYRAIHCPLIRFTSNTDY-SPEQQLTLLKQHKLWIFVSK 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV +A L Q+ A+G+ T AL G L P+ + +L + + Sbjct: 65 QAVDYALKDLSQEQLDQFLGHTLIAVGKATQKALQPY-GLSALVPKTPDSEGILALINQF 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRC--------AIHYDGAEEAMR 173 A L++RG+ GR L+ L ++ Y R A+ AE+ + Sbjct: 124 SLPADYPILLIRGDKGRGLLEQELGGP-YQLGVLPVYHRIELTAALPPAMQQASAEKPIG 182 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV--SERLAKLARELGWQDIK 231 W VVTSG++L+ L + + +++++ S R++ LAR++G+ + Sbjct: 183 W--------VVTSGQILE----LTDKMLSTAGITPEQVVIISGSSRISDLARQMGYTNCY 230 Query: 232 VADNADNDALLRA 244 A +A N ++ A Sbjct: 231 TAKDASNAEIISA 243 >UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31JG4_THICR Length = 264 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 115/256 (44%), Gaps = 15/256 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ L TRP E L +R G P ++ P + LPQ A L D +F +S Sbjct: 8 LTFLNTRPVEQAEALSQSVREKGHQVLACPTLKICP-RSLPQQAG--VTLSTFDKVFFIS 64 Query: 61 QHAVA-FAQ--SQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 Q+AV F +Q + + FAIG++T A+ + ++ ++E LLQ Sbjct: 65 QNAVKQFVDMWQSAYQTHPVFAEKTECFAIGQSTYNAMKALDWPVAKVHSNQYVTEALLQ 124 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LQN+ ++ LI++G GGR + + L A GA VT Y+R + A+ + AR Sbjct: 125 SEVLQNLTDQQCLIVKGKGGRPTLAEGLIAAGATVTEWAVYERVPADFCDAQWQVFRSAR 184 Query: 178 EVTMVVVTSG------EMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD-I 230 +++ + +ML+ S + WL ++V S+R+ ++ WQ + Sbjct: 185 HPVLLISSLDAWYGLEKMLKN--SGYGSKNDQAWLFLQDVIVFSDRIKHALQQQEWQGRL 242 Query: 231 KVADNADNDALLRALQ 246 V N +L AL+ Sbjct: 243 FVVPQQSNAGILTALE 258 >UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KW75_HALNC Length = 256 Score = 67.4 bits (163), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 69/249 (27%), Positives = 109/249 (43%), Gaps = 16/249 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTL--GQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 ++I +TRP A +EL + +L ++PL+ F+P + + +A + D Sbjct: 7 LTIGLTRPDGANDELAKAISSLLPDATLLNWPLLTFAPIPERQKALSAMARITAGDWAIF 66 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQ--KILYPQDREISEVLL 116 +S AV FA LH P L + A+G TT A+ ++ ++ P + SE LL Sbjct: 67 VSPRAVRFAH-DLHDLT-ALPGL-HWAAVGDTTTAAIQSLFSDPPQVHRPSSTQDSEGLL 123 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 ++ + G + RG GRE + DTL G V Y+R A+ Sbjct: 124 ASLPIEAMRGHTVWLFRGQTGRETLADTLRQNGITVIPVPVYRRNCTRRPAHLSAL---- 179 Query: 177 REVTMVVVTSGE---MLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V+T+ E L+QL + LLHC L+V++ R AR LG+ V Sbjct: 180 --PSTWVITAPESLRCLRQLADTLESAEDRARLLHCNLVVINARTEARARSLGFTGAIVR 237 Query: 234 DNADNDALL 242 A +DA L Sbjct: 238 AEAPDDAAL 246 >UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT3_THET1 Length = 266 Score = 67.4 bits (163), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 112/249 (44%), Gaps = 13/249 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I++TRP+ LV L + G V P IE +P +L +L ALG D + S + Sbjct: 19 IVITRPNHQANSLVKLLESSGAVPILLPTIEINPNVASSELDAELNALGSYDWVVFTSVN 78 Query: 63 AVAFAQSQLHQ---QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V +L Q ++ RL + IG +T AL + G ++ D I+E LLQ Sbjct: 79 GVKIFFDRLRQLGLEEVPLSRL-KFACIGPSTKSALESY-GIRVDVMPDSYIAEALLQAL 136 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++++G+R L+ R + R ++ L A GA V Y+ + YD E ++ + Sbjct: 137 LDRDVSGQRILLARADSARPVLRKGLEAAGAIVREVPIYRTIPVKYD--REYLKDLLAQS 194 Query: 180 TMVVVTSGEMLQQLWSLI--PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + TS ++ + P + + + C + A A+ELG + VA+ Sbjct: 195 NAITFTSSSTVKHFLDSLGDPSYLPQSLCVAC----IGPITADTAKELGLRVDVVANVYT 250 Query: 238 NDALLRALQ 246 + L++A++ Sbjct: 251 VEGLVKAIE 259 >UniRef50_Q7VKW9 Possible uroporphyrinogen III synthase n=1 Tax=Haemophilus ducreyi RepID=Q7VKW9_HAEDU Length = 251 Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 113/247 (45%), Gaps = 6/247 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++L+T P+ ++LV + A + P+ G L L ++ L D + LS Sbjct: 1 MNVLITYPASRAQKLVDMCQQHRIFAIYQPIFSVELGADLLDLPSAMSRLNAGDNVIILS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A FA L + +YF + A + + + + YP D E LLQL + Sbjct: 61 KEAFDFAWQTLADTGFAYRADLNYFVADKYLAAYVTAKTTRPVHYP-DTEQCNQLLQLGK 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + K+ LIL R L + L A +V + CY I A+ ++ +A + Sbjct: 120 LLQLTDKKVLILCAEEQRGLFQNQL-AEAKQVQYLACYYHKHIEQLTAQLSLAKRAG-ID 177 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD--IKVADNADN 238 +++ + ++L L+ I WL+ RL+V+S+ +A +A +LGWQ + +A DN Sbjct: 178 TILIENEDVLLTLYEQIAAE-DCQWLVKTRLVVISQHIANIAEKLGWQSDQVIIAGQTDN 236 Query: 239 DALLRAL 245 LL + Sbjct: 237 QTLLNTM 243 >UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III C-methyltransferase n=6 Tax=Ralstonia RepID=A3RYV4_RALSO Length = 1065 Score = 65.5 bits (158), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 73/253 (28%), Positives = 109/253 (43%), Gaps = 22/253 (8%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP LV+ L G FPL++ +P L L LA L+ +S + Sbjct: 394 VVVTRPRAQALMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 453 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALAL---------HTVSGQKILYPQDREISE 113 AV A + + + R WP+ +G +A AL H+V + R+ SE Sbjct: 454 AVQQAFAAMPEGFR-WPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSE 512 Query: 114 VLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 L + ++G+ LI+RGNGGRE + D L G V E Y+R D A Sbjct: 513 ALYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAA---- 568 Query: 174 WQA-REVTMV----VVTSGEMLQQLWSLIPQWYR--EHWLLHCR-LLVVSERLAKLAREL 225 W A REV +TS E ++ L SL E LH R+ + A+ L Sbjct: 569 WAALREVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSL 628 Query: 226 GWQDIKVADNADN 238 G++D+ + D+ Sbjct: 629 GFRDVTLTGAGDD 641 >UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella RepID=Q2KYG5_BORA1 Length = 266 Score = 64.3 bits (155), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 96/223 (43%), Gaps = 19/223 (8%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS--PGQQLPQLADQLAALGESDLLFALSQ 61 ++TRP E L RLR G P + P + P+ D DL+ +S Sbjct: 13 VLTRPEGRNEALAGRLRAAGWEVCVLPALRIVALPAPRAPRPEDY-------DLVVFVSG 65 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALAL----HTVSGQKILYPQ---DREISEV 114 +A Q++ WP +G +A AL + + +LYP SE Sbjct: 66 NAARLYLKQVYASAGAWPAATVAATVGPGSAQALFESGYFGANTTVLYPDISAPTHDSEA 125 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE-EAMR 173 L Q+ Q +R L++RG GR + + L GA+VT YQR +D A +A+R Sbjct: 126 LWQVLSAQGALPRRVLLVRGTQGRNWLAERLREAGAQVTAYAAYQRLPAQWDAATLDALR 185 Query: 174 WQARE--VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV 214 AR+ V ++TSGE + + + I + W +CR ++ Sbjct: 186 AWARQGRVATWLLTSGESIDAVAAQIARADLLSWWRNCRYVIT 228 >UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralstonia eutropha JMP134 RepID=Q474V0_RALEJ Length = 689 Score = 63.2 bits (152), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 85/201 (42%), Gaps = 33/201 (16%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L + L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQAAGLDVLGFPLLSIGPAADDAPLRAALARLDQFALVIFVSP 64 Query: 62 HAVAFAQSQLHQ----QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREI------ 111 +A+ +A L +WP +G + +AL + + I+ P R I Sbjct: 65 NAIQYAVDALAVVQGIAAAQWPPGVPVAVVGPASVMAL---AERGIVAPDYRVIAPAGAD 121 Query: 112 ----------------SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC 155 SE L E + G+ LI+RGNGGR+ +GD L GA+VT Sbjct: 122 GNGTNGGANCEEARFDSEALWAQLEPAALQGRSVLIVRGNGGRDWLGDRLREAGADVTAV 181 Query: 156 ECYQRCAIHYDGAEEAMRWQA 176 E YQR AM+WQA Sbjct: 182 EAYQRTLPE----PTAMQWQA 198 >UniRef50_C4GFP3 Putative uncharacterized protein n=1 Tax=Kingella oralis ATCC 51147 RepID=C4GFP3_9NEIS Length = 241 Score = 62.8 bits (151), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 71/159 (44%), Gaps = 15/159 (9%) Query: 50 LGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDR 109 + + LF +S A A + K P + A+G TA AL I PQ+ Sbjct: 49 IAPAQALFWVSPTAAEIAAPHIGSLKTKIP----HIAVGSQTAQALRQQGFANIHAPQNG 104 Query: 110 EISEVLLQLPELQNIA-GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA 168 SE L LP + G +I+RG GGRE + TL RG V + ECYQR Sbjct: 105 NDSEAALALPIWHTLPQGGTIVIIRGQGGREHLAQTLHQRGFAVQYAECYQRI------- 157 Query: 169 EEAMRWQAREVTMVV---VTSGEMLQQLWSLIPQWYREH 204 + + WQ + VTS ++ Q+L++ PQ + ++ Sbjct: 158 PQPLNWQTFQAAQAQAAWVTSSQLAQELFTQCPQAFTQN 196 >UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Leptothrix cholodnii SP-6 RepID=B1Y161_LEPCP Length = 267 Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 104/244 (42%), Gaps = 22/244 (9%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQL-AALGESDLLFALSQ 61 +LVTRP P +E V RLR LGQ A PL+ P L + ++ +S Sbjct: 12 LLVTRPQPQADEWVERLRGLGQPACAAPLMVIEPVAAFAAAVQAAWQRLADCRMVMFVSP 71 Query: 62 HAVA--FAQSQLHQQDRKWPRLPDYFAIGRTTALALHT-----VSGQKILYPQDREISEV 114 +AV FAQ WP A G T AL + D+ +E Sbjct: 72 NAVLQFFAQ---RPAGLPWPTDTLAAATGPGTVAALQSKGVAAAQIVAPAADADQFDAET 128 Query: 115 L-LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA----E 169 L LQ E Q AG++ LI+RG GR+ + TL GA+V Y+R A + G Sbjct: 129 LWLQRLESQTWAGRQVLIVRGEDGRDWLASTLRHHGAQVDLLAAYRRTAPAWSGELLDLL 188 Query: 170 EAMRWQAREVTMVVVTSGEM--LQQLWSLIPQWYREHWLLHCRLLVVSE-RLAKLARELG 226 + +R + ++ + +S + L PQ +R LH V + R+A+ A LG Sbjct: 189 QRVRQRPQDYAWLFSSSQAIGHLAAFMQTAPQAWRA---LHDVPAVATHLRIAQTATSLG 245 Query: 227 WQDI 230 W+ + Sbjct: 246 WRTV 249 >UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAH2_BREBN Length = 270 Score = 57.8 bits (138), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 100/244 (40%), Gaps = 2/244 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR ELV ++ LG A+ FPL++ P +L + + L D + S + Sbjct: 15 IMVTRARSQVRELVEQIERLGGEAYAFPLLKMMPPTDTAKLDEAITQLPAFDWVVFTSVN 74 Query: 63 AVAFAQSQLHQQDRKWPRLPDYF-AIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V F ++ + A+G TA AL + + P D ++E LL Sbjct: 75 GVRFFLERMREVGVGLEAFTGKIAAVGPKTAKALEHHGLEVAVIPSDY-VAEGLLSSLYD 133 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G+R L+ R + R+ + L G VT + Y E A + Q + + Sbjct: 134 QLLPGQRVLLPRADIARKALPKELARLGLAVTEVDVYHTVIDAEHAPEAAEKLQQGLIDI 193 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ TS + + + + WL H ++ + A A++ G VA + L Sbjct: 194 ILFTSSSTVTHFMAAMEPYASLDWLKHVQIACIGPITADTAKQNGLSVHAVASEYTVEGL 253 Query: 242 LRAL 245 L A+ Sbjct: 254 LAAI 257 >UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea blandensis MED297 RepID=A4BAP9_9GAMM Length = 246 Score = 56.6 bits (135), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 90/208 (43%), Gaps = 15/208 (7%) Query: 40 LPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPD---YFAIGRTTALALH 96 LPQ A+ DL + + A+ + D WP P + G TA L Sbjct: 38 LPQTAEHRNQWLNLDLFSGVVCVSPTAAEVLVAALDEFWPMPPSGVHWLCNGPRTAEVL- 96 Query: 97 TVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCE 156 + +G ++PQ +E +L LPE Q G + LI++G GGR + TLT RGA T Sbjct: 97 SEAGLTPVFPQQGHTAEQVLALPEAQCAQGDKWLIVKGEGGRVTLAQTLTERGAIATELP 156 Query: 157 CYQRCAIHYDGAE--EAMRWQAREVTMVVVTSGE-MLQQLWSLIPQWYREHWLLHCRLLV 213 Y+R A+ D + ++R A + + GE +L Q L W E W V Sbjct: 157 VYRR-AVDNDALQYMTSIRADADALWLSSEFLGESLLNQGRDLWQSWTGEWW-------V 208 Query: 214 VSERLAKLARELGWQDIKVADNADNDAL 241 S RL + G + ++VA A AL Sbjct: 209 SSPRLKDWCQAQGCRRVRVASGATVQAL 236 >UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERASE AND UROPORPHYRINOGEN-III SYNTHASE TRANSMEMBRANE PROTEIN n=3 Tax=Cupriavidus RepID=B3R610_CUPTR Length = 712 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 85/201 (42%), Gaps = 30/201 (14%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQGAGLDVLSFPLLAIGPAADDAPLRAALARLDTFALVVFVSP 64 Query: 62 HAVAFAQSQLHQ-QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREI--------- 111 +A+AFA L Q R P A+ ++ ++ + I P R I Sbjct: 65 NAIAFALDALAGVQGSAVARWPVPVAVAVVGPASVAALAERGIAAPAYRVIAPAGANANG 124 Query: 112 ----------------SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC 155 SE L + +AGK LI+RGNGGR+ +GD L GA+V Sbjct: 125 AGHDDTVPDAEALRFDSEALWAQLDPAALAGKPVLIIRGNGGRDWLGDRLREAGAQVEAV 184 Query: 156 ECYQRCAIHYDGAEEAMRWQA 176 E YQR + G AM+WQA Sbjct: 185 EAYQRT-LPEPG---AMQWQA 201 >UniRef50_C0DSC1 Putative uncharacterized protein n=1 Tax=Eikenella corrodens ATCC 23834 RepID=C0DSC1_EIKCO Length = 251 Score = 53.1 bits (126), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 41/129 (31%), Positives = 62/129 (48%), Gaps = 11/129 (8%) Query: 85 FAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNI-AGKRALILRGNGGRELIGD 143 A+G TA AL +I+ P + SE +L LP Q + G +I+RG GR + D Sbjct: 86 IAVGSGTAKALQQAGFARIVAPDNGHDSEAVLALPLWQRLNPGASVVIIRGREGRNTLPD 145 Query: 144 TLTARGAEVTFCECYQRCAIHYD-----GAEEAMRW--QAREVTMVVVTS-GEMLQQLWS 195 TL RG +V + YQR + D A+ A W A +V ++ + + QQL S Sbjct: 146 TLYRRGFQVACADIYQRQPLMPDWTLFTAAQPAAAWITSAEQVRLLFAAAPASLTQQLQS 205 Query: 196 LIPQWYREH 204 L+ ++ H Sbjct: 206 LL--YFAHH 212 >UniRef50_B4S2W7 Uroporphyrinogen-III synthetase n=2 Tax=Alteromonas macleodii RepID=B4S2W7_ALTMD Length = 243 Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 99/213 (46%), Gaps = 22/213 (10%) Query: 40 LPQLADQLAAL-----GESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTA-- 92 +P L++Q AA +++ S +AV S L + P + A+G TA Sbjct: 34 VPVLSEQYAAAEFLSHNAINVIIVTSVYAVDTVVSGLKKTAAAPPLV---VAVGDATAHK 90 Query: 93 --LALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGA 150 L +S I P+ SE +L + +L ++ +I++G GGR+ I + L +G Sbjct: 91 LRAGLSELSSVNIAIPK-VHTSEGILAMHQLNEANCQQVVIIKGEGGRDAIANGLDEKGM 149 Query: 151 EV-TFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHC 209 V +FC Y+R + + RW+ EV+ ++ TS M Q LI Q+ + LL Sbjct: 150 SVNSFC-VYKREPLTRPIYTK--RWKLGEVSGIIATSEAMALQ---LIEQF--GNALLAY 201 Query: 210 RLLVVSERLAKLARELGWQDIKVADNADNDALL 242 L VS R+AK G +++ V A + AL+ Sbjct: 202 PWLTVSSRIAKTLTNKGIEEVAVCQRATDQALI 234 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 101/240 (42%), Gaps = 8/240 (3%) Query: 10 PAGEE--LVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAV--A 65 PAG+E LV RLR LG A PLI P + L LA L D + S + V Sbjct: 317 PAGQETFLVERLRALGAEAVIHPLIRILPPEDWGPLDAALADLARFDWVVFTSANGVRAT 376 Query: 66 FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIA 125 + +L + R AIG TA AL + + P D+ I+E + + +A Sbjct: 377 LERLRLLGGGSELLREKRLAAIGPATARALREYELEPDIVP-DKFIAEAVAAQLIARGVA 435 Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 G R L+ R RE++ L GA V Y+ + D A +A +A + + +T Sbjct: 436 GARVLVARAAEAREILPRRLEEAGATVVVVPAYRTELLPLDEAIQAA-LEAGTIDWIFLT 494 Query: 186 SGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 + + L + + R R+ + A ARELG + VAD + L+ A+ Sbjct: 495 ASSTARALAAALGDIKRLSD--RIRIAAIGPVTAGTARELGLRVDVVADTYTAEGLIEAV 552 >UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobacteria RepID=HEM4_SYNE7 Length = 264 Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 5/163 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL TR + ++LR G P +E P L + +AA+ + D L S Sbjct: 10 TILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIADFDWLILASA 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAI-GRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV Q +L Q + W +P A+ G+ TA L G+ P + ++ P Sbjct: 70 NAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPEFIAESLVEHFP- 128 Query: 121 LQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQ-RC 161 Q +AG+R L R GGRE I L ++GA V Y+ RC Sbjct: 129 -QPVAGQRLLFPRVETGGREQITQALQSQGAIVVEVPAYESRC 170 >UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillaceae RepID=C5D5K6_GEOSW Length = 266 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/246 (21%), Positives = 100/246 (40%), Gaps = 7/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR + +LR G PLI SP ++ + L D L S Sbjct: 9 TVLVTRGKEQAKAFSEKLRKAGATPIEIPLISISPSSHREEIERCVRQLPNYDWLIFTSA 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F +K LP +G+ TA AL T P + ++E +++ + Sbjct: 69 NGVRF----FFPFVKKETPLPKVAVVGKKTAAALKTYGVSPAAIPSEF-VAEGMIEALKP 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR-WQAREVT 180 R L+++GN R ++ D L GA++T Y+ ++ G E+ + + R++ Sbjct: 124 LVKPRDRVLLVKGNLARPVLRDALINMGADITDLIVYETL-MNESGKEQLLYLLRERKLD 182 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TS +Q ++ + L C + + + A + G D D Sbjct: 183 VITFTSSSTVQSFIRMMEEEDIASLLSGCVIACIGPITKETAEKAGLAVHICPDEYTIDD 242 Query: 241 LLRALQ 246 +++ ++ Sbjct: 243 MIKEME 248 >UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polynucleobacter necessarius RepID=A4SWL1_POLSQ Length = 274 Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 122/272 (44%), Gaps = 38/272 (13%) Query: 2 SILVTRPSPAGEELVSRL-----------RTLGQVAWHFPLIEFSPGQQLPQLADQLAA- 49 +I++TRP+ +L+ L R+L ++ PL+ P LAD +A+ Sbjct: 5 TIVITRPTGQARQLIEVLTKVIEASAIAKRSLPELV-SLPLLTIVPKSD-EHLADSIAST 62 Query: 50 LGESDLLFALSQHAVAFAQSQLHQQDRKW----PRLPDYFAIGRTTALALHTVSGQKILY 105 L ++DL +S +AV +S + +R W R+ +G ++ LAL + Y Sbjct: 63 LQDADLAIFVSPNAV---ESVMRLLERDWQDFSKRIIPIGVMGGSSRLALKNHGIGQEDY 119 Query: 106 P--------QDREISEVLLQLPELQNI----AGKRALILRGNGGRELIGDTLTARGAEVT 153 P +R SE L Q ELQ + K+ +I +G+GGRE + DTL GA V Sbjct: 120 PTSIYMPSINERWDSEGLWQ--ELQTLDWDWTHKKVVIFKGDGGREWLADTLQKAGATVE 177 Query: 154 FCECYQRCAIHYDG-AEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLL 212 Y R + D A + + ++ ++TS E ++ L +I + + L L Sbjct: 178 AISTYTRVPLDIDNPAWQVIHEMDFSKSLWLLTSSEAVRYLGEVIRDQF-PYGLESASAL 236 Query: 213 VVSERLAKLARELGWQDIKVADNADNDALLRA 244 +A A +G+ ++ ++ D +AL++ Sbjct: 237 CPHHNIADAAEAIGFGEVFTSEPGD-EALIKT 267 >UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH Length = 513 Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 78/198 (39%), Gaps = 3/198 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTR ELV L LG P I+ P + L + + L + D + S Sbjct: 258 TIVVTRARVQASELVGSLSALGARCIEIPTIQVVPPRDPAPLVNAVKNLSDFDWVVFTSV 317 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V L+ Q D + + IG T L + P+ V+ Sbjct: 318 NGVKLFFKTLYGEQMDVRALGGLKFACIGPATKAELFVHGIVSDILPKTYMAESVVEAFS 377 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ I GKR L+ R R ++ + L GA VT Y+ A H D AE A +V Sbjct: 378 NVE-IQGKRVLLPRAKQARTILPEELDKLGARVTEVTAYETIAEHLDEAELARLVAESKV 436 Query: 180 TMVVVTSGEMLQQLWSLI 197 +V TS ++ L+ Sbjct: 437 DIVTFTSSSTVENFKRLV 454 >UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chloroflexus RepID=B8G819_CHLAD Length = 254 Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 69/248 (27%), Positives = 106/248 (42%), Gaps = 20/248 (8%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLA--ALGESDLLFALS 60 I +TRP+ G+ L +RLR LG + PLI ++P L LA A G D L S Sbjct: 9 IAITRPAGRGDTLAARLRALGAIPLLTPLIAYAPPADPAPLQHALAQLAAGTYDWLVVTS 68 Query: 61 QHAV-AFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + AV A++ + P A+G+ TA G++ D E+ L + Sbjct: 69 RQAVQVLAEATV-------PTTTAIAAVGKATAADCRRTWGREPAGVPDEELGAALPNV- 120 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + GKR L+ + + L A GA V Y R AE A ++ + Sbjct: 121 -MGTLTGKRILLPCADIAPSTLTAALQAAGAIVDRVTAY-RTISSPAAAELAAALRSGTI 178 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLV-VSERLAKLARELGWQDIKVADNADN 238 +V+ SG +Q+ +L+P C LV + A + ELG +A ++ Sbjct: 179 DAIVLASGSAARQIPALLPPQT------QCPPLVCIGPSTAAVCTELGLPVAAIAIRPND 232 Query: 239 DALLRALQ 246 DALL AL+ Sbjct: 233 DALLAALE 240 >UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=7 Tax=cellular organisms RepID=A0LN72_SYNFM Length = 519 Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 81/200 (40%), Gaps = 9/200 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR + L LG FP I P +L + + L D S + Sbjct: 256 IVVTRAREQASDFKGMLTELGAHCIEFPTIAIEPPPSWRELDEAIRRLASYDWAIFTSVN 315 Query: 63 AVAFAQSQLHQ-----QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 V F +L ++ K RL AIG TA AL + L P + +L Sbjct: 316 GVRFFMERLRALGLDVRELKGVRLA---AIGPKTAEALEKTGLRVDLVPSEYRAESILDS 372 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 L + ++ +R LI R R+++ +TL A+GA V Y+ G E A R++ Sbjct: 373 LGD-ADLRERRFLIPRAMVARDILPETLRAKGALVEVVPAYRTVIPRERGPEIAERFRKA 431 Query: 178 EVTMVVVTSGEMLQQLWSLI 197 E+ + TS + +SL Sbjct: 432 EIHCLTFTSSSTVSNFFSLF 451 >UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bacteria RepID=D2L438_9DELT Length = 514 Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 85/198 (42%), Gaps = 3/198 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTR +LV L G + FP IE +P + + L + D + S + Sbjct: 255 VVVTRSREQASDLVRLLAEEGACCYEFPAIEIAPLADTTPVRQAASRLYDYDWVIFTSVN 314 Query: 63 AVA--FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V FA+ D + AIG TA AL + G K + +R ++E +++ Sbjct: 315 GVKCFFAEVDALGLDARAFAGIRIAAIGPATAEALAS-KGLKADFLPERFVAESVVEGLL 373 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 IA +R LI R R+++ + L GA+V+ Y + D E +A E+ Sbjct: 374 ALGIADRRVLIPRAREARDVLPEKLAEAGADVSVLPVYDTRPVDQDPQEILEAIRAGEIR 433 Query: 181 MVVVTSGEMLQQLWSLIP 198 V TS ++ ++ IP Sbjct: 434 YVTFTSSSTVKNFFAKIP 451 >UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02D79_SOLUE Length = 494 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 4/160 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR + L + L +LG P IE P L +A L D L S + Sbjct: 248 IVVTRAREQADALGAALSSLGAGVIELPTIEIGPAADSGPLERAIAELETYDWLIFTSAN 307 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V F +L + ++ R ALH K+ ++E LL+ Sbjct: 308 GVRFFVERLDDLRKLRSKICAIGPATRAAVEALHV----KVDLMGKEYVAEGLLEAFAAH 363 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA 162 ++AGKR L+ R R+L+ L RGA+V E Y+ A Sbjct: 364 DLAGKRVLLPRAAVARDLVPVELAKRGAQVDVVEAYRTAA 403 >UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=23 Tax=cellular organisms RepID=Q2RJ27_MOOTA Length = 520 Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 63/248 (25%), Positives = 97/248 (39%), Gaps = 9/248 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP E L L LG +FP+I P L L A+GE D + S + Sbjct: 259 VIVTRPRAQAEGLTRSLADLGAEVINFPVIRTEPPADWHPLDTALDAIGEFDWIIFTSAN 318 Query: 63 AVAFAQSQL---HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYP-QDREISEVLLQL 118 V + +L HQ R + AIG T+ AL + +L Q RE + Sbjct: 319 GVRYFWRRLLERHQDIRSLAGI-RIAAIGPATSRALKE---RGLLTDWQPREYVAEAVAS 374 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + G+R L+ R + R + L +GAEVT Y+ + A + Sbjct: 375 GLGPRVRGRRVLLPRADIARPFLAVDLRRQGAEVTEVTAYRTVKNEENAGSLKEMLAAGK 434 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V V TS ++ L+ + + + + A ARE G Q A Sbjct: 435 VAAVTFTSSSTVRAFLDLLGDGALD-LVQGIDVFCLGPVTAATAREAGLQVAATAGEYTE 493 Query: 239 DALLRALQ 246 + L+RA++ Sbjct: 494 EGLVRAME 501 >UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase n=1 Tax=cyanobacterium UCYN-A RepID=UPI0001C33642 Length = 504 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 83/203 (40%), Gaps = 7/203 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TR + + +L+ G PL+E P +L + + D L S + Sbjct: 248 VIITRSHESSSQFKFQLQEAGADVITLPLLEILPPSSWERLDGAIQEISSFDWLVLTSAN 307 Query: 63 AVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V F +LH +D + +G+ TA L + P D ++ PE Sbjct: 308 GVKFFMERLHDLGKDIRILNNIKIAVVGKKTADYLKKFYLKPNFIPSDFIADSLVENFPE 367 Query: 121 LQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQR-CAIHYDGAEEAMRWQARE 178 +I GK+ L R GGR+++ +GA +T YQ C + D E + + Sbjct: 368 --DINGKKILFPRVETGGRDILLKEFIKKGASITEVPAYQSICPKNIDN-EIWKILKNEQ 424 Query: 179 VTMVVVTSGEMLQQLWSLIPQWY 201 V ++ TS ++++ + L + Sbjct: 425 VDIITFTSSKIVKHFYHLFKNIF 447 >UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=2 Tax=Synechococcus RepID=Q2JNU8_SYNJB Length = 500 Score = 48.5 bits (114), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 90/205 (43%), Gaps = 13/205 (6%) Query: 2 SILVTRP---SPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 ++LVTR SPA EL L+ G P + P L +A LG+ + L Sbjct: 246 TVLVTRSEGQSPAFREL---LQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLL 302 Query: 59 LSQHAVAFAQSQLHQQDRKWPRL-PDYFA-IGRTTALALHTVSGQKILYPQDREISEVLL 116 S + V +LH+Q R L P A +G TA L L PQ+ ++E LL Sbjct: 303 TSANGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEF-VAEALL 361 Query: 117 QL-PELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 Q+ PE I+G+R L R +GGRE + L RGAEV YQ + Sbjct: 362 QVWPE--PISGQRILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEAL 419 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQ 199 +A +V ++ S + +Q LI Q Sbjct: 420 KAHQVDILTFASSKTVQHFAHLIRQ 444 >UniRef50_C5ABI2 Uncharacterized enzyme of heme biosynthesis n=5 Tax=Burkholderia RepID=C5ABI2_BURGB Length = 757 Score = 47.8 bits (112), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA----------IH--YD 166 P +AGKR LI+RG+GGRE + L GAEV Y+R +H Sbjct: 230 PPAGPLAGKRVLIVRGDGGREWLATRLREAGAEVELVAAYRRIVPEPSIGAWERVHALLG 289 Query: 167 GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE---HWLLHCRLLVVSERLAKLAR 223 GA A W +VTS E ++ L L LLH L+ R+A AR Sbjct: 290 GAPHA--W--------LVTSSEGVRNLHELAVDHLTAAEIEALLHAPLVAPHSRIADTAR 339 Query: 224 ELGWQDIKVADNADNDALLRALQ 246 LG+ I + A ++ ++RA + Sbjct: 340 ALGFDRITQS-GAGDERIVRAFR 361 >UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7MKX3_CRYCD Length = 579 Score = 47.4 bits (111), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 68/263 (25%), Positives = 101/263 (38%), Gaps = 20/263 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ-------QLPQLADQLAALGESD 54 SI+VTR L S L TLG FP I P L +LA A + ES Sbjct: 309 SIVVTRSREQASVLSSGLSTLGAQVVEFPTIAIKPRSIDAHIRSALMRLASDAAHVRESY 368 Query: 55 --LLFALSQHAVAF--AQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDRE 110 ++F + F A ++LH R + AIG TA LH + P+ Sbjct: 369 DWVVFTSANGVQCFFAALNELHLDARSLGGV-KVAAIGPATAAELHNQGISPDVVPEKFI 427 Query: 111 ISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE 170 V L E G R L+ R R+ + + LT GA+V Y H + A + Sbjct: 428 AESVAQALVESGVGRGTRVLLPRAAVARDALPNRLTQAGAQVEVLPLYDTVIPHAEVAAQ 487 Query: 171 --AMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ 228 A +A EV+ + TS ++ ++ E L+H V + + + + Sbjct: 488 DLATSLRAGEVSAITFTSSSTVRNFKEMLAAVMPESELIHLLETVTCASIGPVTSDT-MR 546 Query: 229 DIKV-----ADNADNDALLRALQ 246 D+ + AD L+ ALQ Sbjct: 547 DLTIPVSVQADTHTIPGLISALQ 569 >UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=1 Tax=Acinetobacter sp. ADP1 RepID=Q6FFA8_ACIAD Length = 256 Score = 47.0 bits (110), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 46/163 (28%), Positives = 69/163 (42%), Gaps = 5/163 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ++ TRP+ +EL + G + PL+ L L +S L+ +S Sbjct: 1 MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L + + L + A+G++TA AL G PQ E SE +LQL Sbjct: 61 PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYY-GISAEIPQ-VETSEGMLQL 118 Query: 119 PELQNIAGKRALIL-RGNGGRELIGDTLTARGAEVTFCECYQR 160 P Q + R + RG GGR+L+ L +G + Y R Sbjct: 119 PVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDR 161 >UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uroporphyrinogen-III synthase n=27 Tax=cellular organisms RepID=B2A1G8_NATTJ Length = 516 Score = 47.0 bits (110), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 3/198 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL ++ LG FP I+ L + + L E + L S Sbjct: 255 NILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSV 314 Query: 62 HAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V ++L D +L AIG T +L + + PQ+ +E L+ L Sbjct: 315 NGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQEYR-AEALIDLM 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + Q +G R LI R RE++ + L +G +V Y+ D + + E+ Sbjct: 374 KEQVKSGDRVLIPRAKEAREVLPEALREQGLKVDVITAYETVKDTKDTEKVRKMLKQNEL 433 Query: 180 TMVVVTSGEMLQQLWSLI 197 + TS ++ ++ Sbjct: 434 DAITFTSSSTVKNFVEVL 451 >UniRef50_Q4FVJ4 Possible uroporphyrinogen-III synthase n=2 Tax=Psychrobacter RepID=Q4FVJ4_PSYA2 Length = 327 Score = 47.0 bits (110), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 7/95 (7%) Query: 85 FAIGRTTALALHTV----SGQKILYPQDREISEVLLQLPELQNI-AGKRALILRGNGGRE 139 A+G TA L+ V + ++L P +E +L +PE+ ++ AG + L+ RG GGR Sbjct: 131 IAVGEATAAVLNEVKLPFASYQVLQPAIAN-NEGMLSMPEIDSLQAGDKLLVWRGLGGRR 189 Query: 140 LIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 L+ DTL ARG + Y+R I D + +W Sbjct: 190 LLVDTLQARGVHIDSIAWYER-KIPVDAMAQYQQW 223 >UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococcus sp. MC-1 RepID=A0L5L4_MAGSM Length = 259 Score = 46.6 bits (109), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 7/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTRP P + + G P++ +P + L +AA+ D + S Sbjct: 10 TILVTRPQPEADATALLILQAGGTPIITPMLNIAPAEDSQPLQQAIAAIHSFDGVLITSA 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A L Q + P FA+G TA L G + P R E L + Sbjct: 70 NAARAYLDALAAQAQPLSGTPPCFAVGPKTAELLR-AGGATVCQPSSRFDGEALAEAINQ 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ L R GRE + D L VT Y+ A+ + + V Sbjct: 129 WQGKGRHFLFPRAAIGRETLIDGLENDDHRVTMVAAYRALPAQQLSAQAHRYLREKRVDA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + S + L+ E +L V +ER+A LG+ +A A + Sbjct: 189 ALFFSSRTATTFFELLISQALEPAEMVLAALSPVTAERMAS----LGFAAHVIAPQATAE 244 Query: 240 ALLRAL 245 +LL+AL Sbjct: 245 SLLQAL 250 >UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C4214B Length = 262 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 66/157 (42%), Gaps = 2/157 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTR E ++++ G ++ PL+ F P + QL + + E D L S + Sbjct: 11 VLVTRAKDQAEPFINQIEEAGGISHIIPLLLFQPVKS-DQLEKAITYINEFDWLVFTSAN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V F + ++ +G T L + L P DR ++E L Sbjct: 70 GVRFFLEEFKKRHLPSSLKARIAVVGEKTEAVLDEYGLKADLLP-DRYVAEDLAVTLTTH 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ 159 AG++ L+ RGN GR L+ L G EV+ Y+ Sbjct: 129 ITAGEKILMPRGNLGRTLLPKELEKAGIEVSDLTIYE 165 >UniRef50_B0TXX7 Uroporphyrinogen-III synthase n=18 Tax=Francisella RepID=B0TXX7_FRAP2 Length = 252 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 59/257 (22%), Positives = 113/257 (43%), Gaps = 35/257 (13%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ILV RP ++L LR+ G A P I + + + LG + +F S Sbjct: 1 MKILVCRPKDDADKLSQLLRSKGYTATSLPCI------NIDYIRIASSVLGYTSYIFT-S 53 Query: 61 QHAVA--FAQSQ---LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVL 115 ++AV FAQ H D+K +++G++TA L G +YP D S+ L Sbjct: 54 KYAVESLFAQYNPELFH--DKKL------YSVGQSTAKTLKKY-GLDAIYPHDHG-SQEL 103 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC---ECYQRCAIHYDGAEEA- 171 L+L ++++ ++ G G EL L +++T C E YQR +A Sbjct: 104 LKLILEEDVSDDSFAVISGVSGNEL----LVKEISQLTKCDKFETYQRVFESVAALSQAY 159 Query: 172 MRWQAREVT--MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD 229 +++ + ++V TS ++ + L + + + + + S ++ K E G+++ Sbjct: 160 LKFIDDGINPDVIVTTSIDIFKSLNRIFGEIVAPRAAI---VTITSPKMLKFVNEQGFEN 216 Query: 230 IKVADNADNDALLRALQ 246 + DN+ + + ++ Sbjct: 217 TLKLEKLDNNCIYQKIR 233 >UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=Nostocaceae RepID=UPI0001C15AC8 Length = 274 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 10/166 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL + LG P +E P L + L D L S Sbjct: 14 TILVTRAVGQSSELSHGITNLGARVIELPALEIGPPSSWRSLDQSILELSTFDWLVFTST 73 Query: 62 HAVA--FAQSQLHQQD-----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 + V FA+ L ++ R+ A+G TA +L + P D + Sbjct: 74 NGVESFFARMALQYKNQQALIRRAINRTKIAAVGEKTAQSLKMHQIEPDFIPPDFIADSL 133 Query: 115 LLQLPELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQ 159 + PE N+AGK+ L R +GGR+++ LT +GA+V Y+ Sbjct: 134 VNNFPE--NLAGKKILFPRVESGGRDILVKELTQKGAQVVEVPAYE 177 >UniRef50_C8PUY1 Uroporphyrinogen-III synthase n=1 Tax=Enhydrobacter aerosaccus SK60 RepID=C8PUY1_9GAMM Length = 262 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 3/62 (4%) Query: 103 ILYPQDR--EISEVLLQLPELQNIA-GKRALILRGNGGRELIGDTLTARGAEVTFCECYQ 159 + +P ++ + +E LL LP +Q++ G + RG GGREL+ DTL A+G +V YQ Sbjct: 112 VTFPGEKRAQNNEGLLNLPVIQSLGKGDYLQVWRGIGGRELLADTLAAKGVQVHLLNLYQ 171 Query: 160 RC 161 R Sbjct: 172 RV 173 >UniRef50_D0SDM4 Uroporphyrinogen-III synthase n=1 Tax=Acinetobacter johnsonii SH046 RepID=D0SDM4_ACIJO Length = 259 Score = 44.3 bits (103), Expect = 0.003, Method: Compositional matrix adjust. Identities = 36/111 (32%), Positives = 54/111 (48%), Gaps = 5/111 (4%) Query: 53 SDLLFALSQHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDRE 110 + ++ +S AV F + L Q L + +G+ TA AL G + P+ E Sbjct: 53 TQVIVVVSPSAVQFGMAHLLQSGLTVSDLQHIQWITVGQKTAQALAEY-GLDSVVPK-VE 110 Query: 111 ISEVLLQLPELQNIAGKRALIL-RGNGGRELIGDTLTARGAEVTFCECYQR 160 SE +LQLP LQN+A ++ RG GGR+ + DTL G + Y+R Sbjct: 111 TSEGMLQLPVLQNLASDASIAFWRGEGGRQFMMDTLMQHGCLILNFVLYER 161 >UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=14 Tax=Acinetobacter RepID=B0VDG2_ACIBY Length = 255 Score = 43.9 bits (102), Expect = 0.005, Method: Compositional matrix adjust. Identities = 48/166 (28%), Positives = 71/166 (42%), Gaps = 11/166 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP---GQQLPQLADQLAALGESDLLF 57 M + TRP EL L+ G PL+E + L QL QL + + Sbjct: 1 MLFINTRPDSRAAELTHALQNKGFQVESLPLLELVAQPFSESLSQLYQQLTG---AQAIV 57 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVL 115 +S AV L Q K L + A+G+ TA LH G + P + E SE + Sbjct: 58 VVSPTAVDVGMQYLTQSGLKIDELKHIQWIAVGQATANRLHDY-GIEAHVP-EVETSEGM 115 Query: 116 LQLPELQNIAGKRALIL-RGNGGRELIGDTLTARGAEVTFCECYQR 160 L LP L + ++ RG GGR+ + +TL +G ++ Y+R Sbjct: 116 LNLPLLHCMQKSGSVAFWRGEGGRQFMMETLQQQGIQILNFVLYRR 161 >UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase n=12 Tax=Cyanobacteria RepID=B0C0D5_ACAM1 Length = 542 Score = 43.9 bits (102), Expect = 0.005, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 106/254 (41%), Gaps = 14/254 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR + L ++G P +E P L +A+L D L S Sbjct: 285 TILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPSSWKALDGAIASLDRFDWLILTSA 344 Query: 62 HAVA-FAQSQLHQQ-DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V F H D + +GR TA L G K Y +++ L++ Sbjct: 345 NGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQ-QGLKADYIPPNFVADALVEHF 403 Query: 120 ELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQ-RC-AIHYDGAEEAMRWQA 176 + + G+ L R +GGR+++ LT +GA V YQ RC A A A+R Q Sbjct: 404 PGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQT 463 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREH----WLLHCRLLVVSERLAKLARE-LGWQDIK 231 V +V S + ++ + L+ Q E WL ++ + + + +E LG DI+ Sbjct: 464 --VDIVTFASSKTVRYFYQLLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIE 521 Query: 232 VADNADNDALLRAL 245 A+ D L +++ Sbjct: 522 -AEEYTLDGLTQSI 534 >UniRef50_C7I1F1 Bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase n=1 Tax=Thiomonas intermedia K12 RepID=C7I1F1_THIIN Length = 335 Score = 42.7 bits (99), Expect = 0.010, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 2/110 (1%) Query: 125 AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVV 183 AG+ ALI RG GR+L+ L A GA+V E Y R A Y+ A+ A + Sbjct: 202 AGRHALIFRGGPGRDLLLRKLEAAGAKVKVIEAYSRLAPEYNAQTAALLQTALGSGGWWL 261 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHC-RLLVVSERLAKLARELGWQDIKV 232 +S E + L L+ + +LH R L + R+A E G+ +++ Sbjct: 262 FSSTEAVHNLQRLLEPAGLDADVLHPQRALAIHPRIASALSEAGFGRVEL 311 >UniRef50_A7IEG5 Uroporphyrinogen III synthase HEM4 n=2 Tax=Xanthobacteraceae RepID=A7IEG5_XANP2 Length = 232 Score = 42.7 bits (99), Expect = 0.010, Method: Compositional matrix adjust. Identities = 35/94 (37%), Positives = 45/94 (47%), Gaps = 14/94 (14%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP-GQQLPQLADQLAALGESDLLFAL 59 M ILVTRP PA + RLRTLG P++ +P LP+ G D + Sbjct: 1 MHILVTRPEPAASQTAERLRTLGHAVTVDPMLRIAPTAPTLPE--------GPFDAVAFT 52 Query: 60 SQHAV-AFAQSQLHQQDRKWPRLPDYFAIGRTTA 92 S + V AFAQ H Q + LP FA+G T+ Sbjct: 53 SINGVKAFAQ---HPQGPDFFHLP-AFAVGPRTS 82 >UniRef50_A9CUB7 Uroporphyrinogen-III synthetase n=1 Tax=Hoeflea phototrophica DFL-43 RepID=A9CUB7_9RHIZ Length = 243 Score = 42.7 bits (99), Expect = 0.011, Method: Compositional matrix adjust. Identities = 57/254 (22%), Positives = 94/254 (37%), Gaps = 24/254 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP P SRLRTLG PL E Q+ D L + + L A S Sbjct: 1 MRVLVTRPEPGASRTASRLRTLGHEPVILPLFE----AQITARPDDLPPVQQVGGLIATS 56 Query: 61 QHAVA-FAQSQLHQQDRKWPRLPDYFAIGRTTALA--------LHTVSGQKILYPQDREI 111 A + F + + +P + +G TA A +H +G R++ Sbjct: 57 ARAFSIFGSNTAPAEYLHFP----VYTVGPATAQAARDAGFHDVHEGAGSA------RDL 106 Query: 112 SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 + L + G L L G+ + + + LTA G + E Y+ + Y + Sbjct: 107 AGALTAQ-SGTAVDGPGLLYLAGSPRKPFLEEALTAEGLPLKVLETYRMDQLSYPTDSQI 165 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + + + S SL+ + L + +S ++ E + Sbjct: 166 LDLLSPAPDAALFYSSNAALGFCSLVSTKNLDKSLQSTFFMCLSPEISSAFPETWMARVI 225 Query: 232 VADNADNDALLRAL 245 A + D D+LL +L Sbjct: 226 SAGHPDEDSLLASL 239 >UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Rhodopirellula baltica RepID=Q7UPD0_RHOBA Length = 510 Score = 42.4 bits (98), Expect = 0.012, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 100/248 (40%), Gaps = 12/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP +L L LG P I+ P ++ + + D L S+ Sbjct: 265 NVLVTRPKDQANQLAKPLEELGANVIVQPAIKICPPDDWSEVDAAIDQIETFDSLVFTSR 324 Query: 62 HAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L R L +G TA L T + P+ + +L L Sbjct: 325 NGVKSFLDRLLDVGRDMRCLGGLKIAVVGDATANVLATYHLRADWIPESFDADALLTTL- 383 Query: 120 ELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 QN K L++R GR+++ D L A G +V Y+ + + + Sbjct: 384 --QNAEPPLKSTLVVRTQRGRDVVTDGLRASGTQVREVVAYENWDVPEMDPATRGKIDEQ 441 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + + +TS + + +W + ++ R+ V+S A+ RELGW+ VA +A Sbjct: 442 PLDWITLTSPATARN----VHRWLGD-FIGETRIAVISPLTAQTVRELGWRVDAVAASAT 496 Query: 238 NDALLRAL 245 +L +A+ Sbjct: 497 MQSLTQAI 504 >UniRef50_C7JEW6 Uroporphyrinogen-III synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JEW6_ACEP3 Length = 242 Score = 42.4 bits (98), Expect = 0.013, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 44/88 (50%) Query: 158 YQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSER 217 Y I + A+ QA +V +V+ S E + +P+ ++ +V+S R Sbjct: 150 YAAKPIQHINAQTCTAIQAAKVAVVLFFSAESAAGWLAALPEAEQKQLAAQASAVVISGR 209 Query: 218 LAKLARELGWQDIKVADNADNDALLRAL 245 +A + R GWQ+I+VAD+ A++ AL Sbjct: 210 VAGVLRAAGWQNIRVADHVSAAAVMDAL 237 >UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepID=A5CNI5_CLAM3 Length = 279 Score = 42.4 bits (98), Expect = 0.013, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 99/250 (39%), Gaps = 20/250 (8%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLA--ALGESDLLFALS 60 +LV R P G+ + LR G P+I F+ Q L LA A G D L S Sbjct: 14 VLVPRGGPWGDGVAYDLRAQGATPVVAPMINFAATQDAQALESALADLAAGSFDWLTVTS 73 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLLQLP 119 V L P A+G TTA AL P D + +L + Sbjct: 74 ATTVDV----LASHRAVVPEGTRIAAVGETTAAALVAAGYTVDFVPSIDSSATALLEEWT 129 Query: 120 ELQNIAG---KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEAMRWQ 175 E+ AG +R L LR + + D L ARG +V Y+ + D E + Sbjct: 130 EMA--AGSPRRRVLTLRSEIAKPTLTDGLIARGHDVRSVVAYRTVGVLVSDRIREDV--S 185 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + V ++VTSG + +Q+ + + L+ C + R AK AR G + VA Sbjct: 186 SGRVRAILVTSGSVAEQVHEQLGD-VPDGVLIAC----IGPRTAKDARRSGVRVDVVASE 240 Query: 236 ADNDALLRAL 245 +L++AL Sbjct: 241 RSAASLIQAL 250 >UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R7V5_9PLAN Length = 505 Score = 42.0 bits (97), Expect = 0.017, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 78/196 (39%), Gaps = 8/196 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESD-LLFALS 60 ++LVTRP+ E L L LG P I + L + L D L+FA + Sbjct: 260 TVLVTRPAQQAESLARPLEELGAAVLLDPAIVIGMPEDSAPLVQAIHTLETYDWLVFASA 319 Query: 61 QHAVAFAQS--QLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 F + L RK + +G T+ AL + + L P++ E + L Sbjct: 320 SGVEKFFEQLISLGYDLRKLAHI-RLAVVGSGTSAALEKLHLRADLVPENFEAESLAAML 378 Query: 119 -PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 PE AGKR LI+R + GRE++ L GA V Y+ R R Sbjct: 379 APE---AAGKRVLIVRASRGREVLPQLLANSGAGVEQVVAYESVDNLVPDPLVVQRLTER 435 Query: 178 EVTMVVVTSGEMLQQL 193 ++ + VTS + L Sbjct: 436 KIDYISVTSSAIATSL 451 >UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonadaceae RepID=A1VRW0_POLNA Length = 287 Score = 41.6 bits (96), Expect = 0.023, Method: Compositional matrix adjust. Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 44/263 (16%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP---GQQLPQLADQLAALGESDLLFAL 59 ++VTRP+P V +L G A F LI+ +P L D AL + Sbjct: 6 VIVTRPAPDAALWVRQLEQAGIAAEAFELIDIAPVGSAADAQALGDAWLALDAYAACLFV 65 Query: 60 SQHAV--------AFAQSQLHQQD---------RKWPRLPDYFAIGRTTALALHT--VSG 100 S HAV AFAQ Q R+ P + A G T AL V Sbjct: 66 SGHAVEHFFKENKAFAQGGYAQAAINNIANSGLRRIPPGLRFMAPGPGTVAALRAAGVPA 125 Query: 101 QKILYP---QDREISEVLLQLPELQNIAGKRALILRG--------NGGRELIGDTLTARG 149 +I P + SE L ++ ++ G++ LI+RG GR+ I G Sbjct: 126 AQIDAPAADASQFDSEALWRVVGARDWQGRKVLIVRGQSAGAQGATSGRDWIVRQWQGAG 185 Query: 150 AEVTFCECYQRCA-IHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIP----QWYREH 204 A V F YQR A I D R + + ++ + +S E + L W R Sbjct: 186 ASVDFVGVYQRRAPILTDAQVARARQASADGSVWLFSSSEAVANLVGQAGLQGVDWGR-- 243 Query: 205 WLLHCRLLVVSERLAKLARELGW 227 R + R+A+ R GW Sbjct: 244 ----ARAVATHPRIAQAVRAAGW 262 >UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus sp. NRRL B-14911 RepID=Q2B6K9_9BACI Length = 259 Score = 41.2 bits (95), Expect = 0.029, Method: Compositional matrix adjust. Identities = 47/214 (21%), Positives = 89/214 (41%), Gaps = 17/214 (7%) Query: 19 LRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA----VAFAQSQLHQQ 74 +R+ G + PL+ F P + ++ + L D + S++A ++FA + Sbjct: 29 IRSYGGIPVEIPLLAFRPAEVTEEILHAVRELPTYDWVIFTSKNALETFISFAG-----R 83 Query: 75 DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ--LPELQNIAGKRALIL 132 + +P++ AIG T A SG + + + +E + LP ++ G + LI Sbjct: 84 NAVFPKIA---AIGTKTERAAEE-SGLAVSFTPEEFAAEGFIDEFLPFVEK--GMKVLIP 137 Query: 133 RGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQ 192 +GN R I D L GAE Y+ G + A+ + + ++ TS ++ Sbjct: 138 KGNKARSYIADELKRAGAEPQEIIIYETGFPEDSGEKLAVMLKNGSLDVLAFTSPSTVEH 197 Query: 193 LWSLIPQWYREHWLLHCRLLVVSERLAKLARELG 226 ++ + E + C + + K A ELG Sbjct: 198 FMEIVRKTGAEAAIKGCLVACIGPVTQKRAEELG 231 >UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4E5B Length = 513 Score = 40.8 bits (94), Expect = 0.036, Method: Compositional matrix adjust. Identities = 66/250 (26%), Positives = 102/250 (40%), Gaps = 11/250 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFALS 60 +LVTRP+ +V +L LG V P +E + L L GE D L S Sbjct: 261 VLVTRPAHQAGGMVRKLEHLGAVVSRLPAVEIRDVDNFASVDRALGQLRHGEWDWLVFTS 320 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDY--FAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V +L R L AIG TA +L + + P SE L Sbjct: 321 ANGVHALLRRLDTIGRDLRDLGGVKLAAIGPKTAESLREYRLRADVVPDTTFSSEGLAGA 380 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAE-EAMRWQA 176 + ++AG+R L+ R N GREL+ L A+ A V Y + + +GA +A+R Sbjct: 381 LK-PHVAGQRVLLARANRGRELLRTEL-AKVATVEQVTVYDQVDVTAPEGAVLDALRRG- 437 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADN 235 E+ V + S + + + + + +L+V+S K R LG+ A Sbjct: 438 -EIRFVTLPSSSIAKGVLAAFDETINGRVERGEIKLIVISPETGKAVRALGYPVAAEATT 496 Query: 236 ADNDALLRAL 245 D L+ A+ Sbjct: 497 FTEDGLIEAV 506 >UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JVU0_DESAC Length = 264 Score = 40.8 bits (94), Expect = 0.038, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 64/152 (42%), Gaps = 3/152 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTR + + V L G A PLIE +L + LA L + D L S + Sbjct: 11 ILVTRAAHQAQSFVRLLEAQGATAITCPLIEIVAPASWQRLDEALARLQDYDDLILTSVN 70 Query: 63 AVAFAQSQLHQQDRKWPRLPDY--FAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV S+L + L +G TA +L Q L P + V+ L Sbjct: 71 AVDMVFSRLGKGVVPQTALDGVRLVCVGPKTAKSLQHYGYQPDLQPDEYRAEAVVAAL-T 129 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEV 152 + + G++ L R R+LI +LT GAEV Sbjct: 130 AEGVRGRKVLYPRAELARDLIPSSLTQAGAEV 161 >UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured marine bacterium 106 RepID=Q6SHZ5_9BACT Length = 275 Score = 40.8 bits (94), Expect = 0.045, Method: Compositional matrix adjust. Identities = 45/238 (18%), Positives = 96/238 (40%), Gaps = 5/238 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + LVTR L L + G + + P + + + + + D S Sbjct: 17 LRFLVTRLDSTESSLSGMLESQGASVLTAQMTQIIPTESWESFDETVQQISKIDWAVFTS 76 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYF---AIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 ++ V S+L+ + +L +G+ TA L L P+ + SE L+ Sbjct: 77 RNGVTHCLSRLNDLEVSAQQLFSSIKTACVGQATASVLTDNGITPELVPEHFQ-SEGLIY 135 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + ++ KR +++ R+++ D+L GA++ Y+ + D + + Sbjct: 136 AFKQHDLFEKRCWLIQAESPRKILQDSLQKMGAQIILTPVYRNVPVAGDYTFLLTELEQQ 195 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 ++ ++ S +Q ++P + E ++ + + AK AR+ GW ++VA N Sbjct: 196 KLDWILFASPSAVQNFHQILPSGFWESLAAEPKIACLGKITAKAARDFGW-SVQVAPN 252 >UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZQM0_9PLAN Length = 485 Score = 40.8 bits (94), Expect = 0.045, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 77/189 (40%), Gaps = 4/189 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 IL+TRP E+L L LG + P I+ SP + D + L + + L S + Sbjct: 241 ILITRPEHQAEDLAHTLAELGADVYLQPAIQISPPSDWTPVDDAIRRLHDFEWLVFSSTN 300 Query: 63 AVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + +L +D + AIG TA L + + P + ++ L Sbjct: 301 GVRYFLDRLFASGEDLRAVGHLHIAAIGPGTADMLAKYHLKADVIPAEYRAESLVEALQA 360 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + +R L+ R + GR+++ L A G EVT YQ E W + + Sbjct: 361 TTD--RQRFLLPRASRGRDVLPTGLAAGGGEVTEIVVYQSDDCMTLSPEIIEAWDDQPID 418 Query: 181 MVVVTSGEM 189 V+VTS + Sbjct: 419 YVIVTSSAI 427 >UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verrucomicrobia RepID=B1ZV86_OPITP Length = 270 Score = 40.4 bits (93), Expect = 0.048, Method: Compositional matrix adjust. Identities = 60/252 (23%), Positives = 102/252 (40%), Gaps = 16/252 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR EL ++L LG PLI S LAD L LG D + S + Sbjct: 15 IIVTRAREQASELSAKLTALGAEVLELPLIRVSKHISKEALADVLLELGSYDWIVFTSAN 74 Query: 63 AVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ---DREISEVLLQ 117 V + + + D + L + +G TA + + + P+ +++ L++ Sbjct: 75 GVRYFFEEFLRIFDDIRSLGLLRFACVGDATAKGIRELHLKVECQPKVATGEALADALIE 134 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ--RCAIHYDGAEEAMRWQ 175 L N + +++ GN R+++ L A V + YQ R + + A R Q Sbjct: 135 TGSLDN---AKVVVITGNLNRDVLVTKLEGAHAIVDQLQVYQTERVDLTDNPAAAEFRTQ 191 Query: 176 AREVTMVVVTSG--EMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + + +S Q +L Q + L + SE L K E+G+ VA Sbjct: 192 GADAVLFASSSAVDSFAAQQAALTLQKGAKPPLFGSIGPLTSESLTKAGLEIGF----VA 247 Query: 234 DNADNDALLRAL 245 + D+L++AL Sbjct: 248 KEPNLDSLVQAL 259 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enteroba... 321 1e-86 UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobac... 302 8e-81 UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacte... 282 7e-75 UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus... 279 6e-74 UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkali... 269 8e-71 UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaprote... 268 1e-70 UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomon... 264 3e-69 UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Paste... 262 7e-69 UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobac... 262 8e-69 UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio... 261 1e-68 UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomon... 257 2e-67 UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methy... 255 8e-67 UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 T... 255 1e-66 UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrional... 252 8e-66 UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptunii... 249 6e-65 UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurel... 247 3e-64 UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiob... 246 4e-64 UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio Re... 245 9e-64 UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thaue... 238 9e-62 UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia ... 238 1e-61 UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shew... 238 1e-61 UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C... 238 1e-61 UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Alloc... 238 2e-61 UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Galli... 237 2e-61 UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456... 234 2e-60 UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteo... 234 2e-60 UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia ... 232 8e-60 UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggi... 230 2e-59 UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gam... 230 4e-59 UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococ... 228 1e-58 UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella... 225 1e-57 UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas ... 224 2e-57 UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylopha... 221 2e-56 UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacil... 220 3e-56 UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomo... 220 3e-56 UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionell... 220 3e-56 UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionel... 219 6e-56 UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolum... 219 8e-56 UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcu... 218 1e-55 UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marin... 217 2e-55 UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanel... 217 2e-55 UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimn... 217 3e-55 UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma pr... 216 5e-55 UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassifi... 216 5e-55 UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus Re... 215 8e-55 UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen... 213 3e-54 UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uropor... 210 3e-53 UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillacea... 210 4e-53 UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burk... 209 6e-53 UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella b... 208 1e-52 UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Terediniba... 208 2e-52 UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromon... 207 3e-52 UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobacu... 207 3e-52 UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marin... 206 6e-52 UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodos... 206 7e-52 UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomon... 203 5e-51 UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uropo... 200 2e-50 UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/... 200 4e-50 UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralston... 199 7e-50 UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsie... 199 7e-50 UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella ch... 198 2e-49 UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfu... 198 2e-49 UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III... 197 2e-49 UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/... 197 3e-49 UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 197 3e-49 UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma p... 196 4e-49 UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacill... 196 8e-49 UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sacch... 195 9e-49 UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bac... 194 2e-48 UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivora... 193 5e-48 UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma p... 191 2e-47 UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia ... 191 2e-47 UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH 191 2e-47 UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine ... 188 1e-46 UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobact... 186 4e-46 UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uropo... 186 5e-46 UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chrom... 186 7e-46 UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyr... 186 7e-46 UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Me... 184 2e-45 UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyr... 183 3e-45 UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio... 182 8e-45 UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicros... 182 9e-45 UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bac... 181 1e-44 UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 181 2e-44 UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERA... 178 1e-43 UniRef50_Q7VKW9 Possible uroporphyrinogen III synthase n=1 Tax=H... 178 1e-43 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 178 2e-43 UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=No... 178 2e-43 UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseud... 178 2e-43 UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepI... 177 3e-43 UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococ... 176 4e-43 UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyri... 176 5e-43 UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Ta... 176 7e-43 UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polyn... 175 9e-43 UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutie... 175 1e-42 UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cry... 174 3e-42 UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halot... 173 7e-42 UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangi... 173 7e-42 UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta prote... 165 1e-39 UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobact... 162 8e-39 UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lepto... 158 2e-37 UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella... 156 4e-37 UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 149 6e-35 UniRef50_C4GFP3 Putative uncharacterized protein n=1 Tax=Kingell... 143 6e-33 UniRef50_B4S2W7 Uroporphyrinogen-III synthetase n=2 Tax=Alteromo... 143 6e-33 UniRef50_B4SRW6 Uroporphyrinogen III synthase HEM4 n=4 Tax=Xanth... 138 1e-31 UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea... 138 1e-31 UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chlor... 138 2e-31 UniRef50_B0TXX7 Uroporphyrinogen-III synthase n=18 Tax=Francisel... 137 3e-31 UniRef50_C0DSC1 Putative uncharacterized protein n=1 Tax=Eikenel... 134 2e-30 UniRef50_UPI0001BC6E7F uroporphyrinogen-III synthase, putative n... 127 3e-28 UniRef50_C8PUY1 Uroporphyrinogen-III synthase n=1 Tax=Enhydrobac... 124 3e-27 UniRef50_C5ABI2 Uncharacterized enzyme of heme biosynthesis n=5 ... 111 3e-23 UniRef50_Q4FVJ4 Possible uroporphyrinogen-III synthase n=2 Tax=P... 108 3e-22 Sequences not found previously or not previously below threshold: UniRef50_C9KL86 Uroporphyrinogen III synthase/methyltransferase ... 185 2e-45 UniRef50_B3T8I0 Putative tetrapyrrole (Corrin/porphyrin) methyla... 175 1e-42 UniRef50_C6D877 Uroporphyrin-III C-methyltransferase n=95 Tax=Fi... 171 1e-41 UniRef50_C7N5L1 Uroporphyrin-III C-methyltransferase n=1 Tax=Sla... 171 2e-41 UniRef50_A7GTE4 Uroporphyrinogen III synthase HEM4 n=72 Tax=Baci... 169 7e-41 UniRef50_D1VCA0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Frank... 169 8e-41 UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase ... 169 8e-41 UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase ... 166 4e-40 UniRef50_Q8GCA7 Uroporphyrinogen III synthase n=1 Tax=Bacillus m... 166 8e-40 UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase ... 166 8e-40 UniRef50_D0WES9 Siroheme synthase n=1 Tax=Slackia exigua ATCC 70... 164 2e-39 UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus... 164 3e-39 UniRef50_B2UQJ4 Uroporphyrin-III C-methyltransferase n=6 Tax=Bac... 163 7e-39 UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desul... 161 2e-38 UniRef50_Q9K8G1 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus... 160 4e-38 UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pir... 160 4e-38 UniRef50_C8WIZ1 Uroporphyrin-III C-methyltransferase n=10 Tax=Ba... 158 2e-37 UniRef50_A9B548 Uroporphyrinogen III synthase HEM4 n=1 Tax=Herpe... 157 3e-37 UniRef50_D2M0D2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacil... 156 4e-37 UniRef50_C2WCN0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Bacil... 154 2e-36 UniRef50_Q2JFR9 Uroporphyrinogen-III synthase / uroporphyrinogen... 153 4e-36 UniRef50_A9GHX2 Uroporphyrinogen-III synthase n=3 Tax=cellular o... 153 4e-36 UniRef50_C1F250 Uroporphyrinogen-III synthase n=1 Tax=Acidobacte... 153 4e-36 UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured... 151 3e-35 UniRef50_A0QR19 Uroporphyrinogen-III synthase n=10 Tax=Actinomyc... 150 3e-35 UniRef50_Q7NL92 Uroporphyrinogen III synthase/methyltransferase ... 150 4e-35 UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uropor... 149 7e-35 UniRef50_Q3B017 Uroporphyrinogen-III synthase n=19 Tax=Cyanobact... 149 8e-35 UniRef50_Q1INI7 Uroporphyrinogen-III synthase n=1 Tax=Candidatus... 149 9e-35 UniRef50_Q180R8 Porphyrin biosynthesis protein includes: uroporp... 148 1e-34 UniRef50_A6C1N1 Uroporphyrin-III C-methyltransferase n=1 Tax=Pla... 148 2e-34 UniRef50_C4DTF5 Uroporphyrinogen-III synthase; uroporphyrinogen-... 147 3e-34 UniRef50_C9Y9I3 Putative uncharacterized protein n=1 Tax=Curviba... 147 3e-34 UniRef50_C1YGP0 Uroporphyrinogen-III synthase; uroporphyrinogen-... 146 5e-34 UniRef50_A6W5L9 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyri... 146 7e-34 UniRef50_A2SK65 Uroporphyrinogen-III synthase n=1 Tax=Methylibiu... 144 2e-33 UniRef50_Q1D8Z7 Uroporphyrinogen-III synthase n=2 Tax=Cystobacte... 144 3e-33 UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 144 3e-33 UniRef50_C5CSC8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Vario... 144 4e-33 UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verru... 143 6e-33 UniRef50_A3ETN4 Uroporphyrin-III C-methyltransferase / synthase ... 142 9e-33 UniRef50_C1PAG5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacil... 140 3e-32 UniRef50_Q0EX10 Putative uroporphyrin-III C-methyltransferase/ur... 140 3e-32 UniRef50_A9KP84 Uroporphyrin-III C-methyltransferase n=4 Tax=Clo... 139 6e-32 UniRef50_Q4JSX6 Uroporphyrin-III C-methyltransferase / uroporphy... 139 8e-32 UniRef50_Q2NF31 HemD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 139 9e-32 UniRef50_O26268 Putative uroporphyrinogen-III synthase n=1 Tax=M... 138 2e-31 UniRef50_Q8EPM9 Uroporphyrinogen-III synthase n=1 Tax=Oceanobaci... 138 2e-31 UniRef50_A7NKU9 Uroporphyrinogen III synthase HEM4 n=2 Tax=Rosei... 138 2e-31 UniRef50_Q31D67 Uroporphyrinogen-III synthase n=7 Tax=Prochloroc... 138 2e-31 UniRef50_P21248 Uroporphyrinogen-III synthase n=4 Tax=Bacillus R... 138 2e-31 UniRef50_B5YJZ5 Uroporphyrinogen III synthase/methyltransferase ... 137 3e-31 UniRef50_C1ZIN7 Uroporphyrin-III C-methyltransferase n=1 Tax=Pla... 136 7e-31 UniRef50_C8NSF6 Uroporphyrin-III C-methyltransferase/uroporphyri... 135 1e-30 UniRef50_A6CN70 HemD n=1 Tax=Bacillus sp. SG-1 RepID=A6CN70_9BACI 133 4e-30 UniRef50_C7P5B9 Uroporphyrinogen III synthase HEM4 n=1 Tax=Metha... 132 8e-30 UniRef50_Q5WEP6 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus... 132 1e-29 UniRef50_A6GI22 Uroporphyrinogen III synthase/methyltransferase ... 132 1e-29 UniRef50_A7Z7A4 HemD n=1 Tax=Bacillus amyloliquefaciens FZB42 Re... 131 2e-29 UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonada... 131 2e-29 UniRef50_D1YA62 Uroporphyrinogen-III synthase n=2 Tax=Propioniba... 130 3e-29 UniRef50_Q59335 Uroporphyrinogen-III synthase n=11 Tax=Chlorobia... 130 4e-29 UniRef50_UPI000050FC32 Uroporphyrin-III C/tetrapyrrole (Corrin/P... 128 2e-28 UniRef50_C6HUG3 Uroporphyrin-III C-methyltransferase / synthase ... 128 2e-28 UniRef50_Q58401 Putative uroporphyrinogen-III synthase n=8 Tax=M... 128 2e-28 UniRef50_C1AA39 Putative uroporphyrinogen-III synthase n=1 Tax=G... 127 3e-28 UniRef50_UPI0001972E7B uroporphyrin-III C-methyltransferase n=1 ... 127 3e-28 UniRef50_UPI0001C42100 uroporphyrinogen-III synthase HemD n=1 Ta... 127 4e-28 UniRef50_Q59294 Uroporphyrinogen-III synthase n=6 Tax=Clostridiu... 127 4e-28 UniRef50_B0K2L5 Uroporphyrin-III C-methyltransferase n=9 Tax=The... 125 1e-27 UniRef50_C0VHI0 Uroporphyrinogen-III synthase n=2 Tax=Acinetobac... 125 1e-27 UniRef50_B2V748 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sulfu... 125 2e-27 UniRef50_C9RF91 Uroporphyrinogen III synthase HEM4 n=2 Tax=Metha... 124 3e-27 UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepI... 124 3e-27 UniRef50_B2UXC3 Uroporphyrinogen III synthase/methyltransferase ... 123 4e-27 UniRef50_D0SDM4 Uroporphyrinogen-III synthase n=1 Tax=Acinetobac... 122 1e-26 UniRef50_A5UND1 Uroporphyrinogen III synthase, HemD n=2 Tax=Meth... 121 1e-26 UniRef50_B3QWI2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chlor... 121 2e-26 UniRef50_C5V9U0 Uroporphyrinogen-III synthase n=2 Tax=Corynebact... 121 2e-26 UniRef50_UPI0001B5826B putative uroporphyrin-III C-methyltransfe... 121 2e-26 UniRef50_A5EW82 Uroporphyrinogen-III synthase family protein Hem... 120 5e-26 UniRef50_D1Y458 Porphyrin biosynthesis protein HemD n=2 Tax=Bact... 119 6e-26 UniRef50_D0J465 Uroporphyrinogen III synthase n=6 Tax=Comamonada... 119 7e-26 UniRef50_C0QQD7 Uroporphyrinogen-III synthase n=1 Tax=Persephone... 118 1e-25 UniRef50_C7M2H6 Uroporphyrin-III C-methyltransferase n=1 Tax=Aci... 118 2e-25 UniRef50_C1SL66 Uroporphyrinogen-III synthase n=1 Tax=Denitrovib... 118 2e-25 UniRef50_A8VZH5 PhoU family protein n=1 Tax=Bacillus selenitired... 116 7e-25 UniRef50_C1DT10 Uroporphyrinogen-III synthase n=2 Tax=Sulfurihyd... 115 1e-24 UniRef50_C5U4M5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Metha... 114 3e-24 UniRef50_Q3IBM6 Uroporphyrinogen III synthase/methyltransferase ... 114 4e-24 UniRef50_A8MGE5 Uroporphyrin-III C-methyltransferase n=1 Tax=Alk... 111 2e-23 UniRef50_Q2IKT0 Uroporphyrinogen-III synthase n=4 Tax=Anaeromyxo... 111 3e-23 UniRef50_B2J0U6 Uroporphyrinogen III synthase HEM4 n=6 Tax=Cyano... 110 4e-23 UniRef50_A8UZZ5 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogen... 110 4e-23 UniRef50_A5WHR1 Uroporphyrinogen-III synthase-like protein n=1 T... 110 5e-23 UniRef50_C2C1P1 Uroporphyrinogen-III synthase n=1 Tax=Listeria g... 109 6e-23 UniRef50_D2RNT3 Uroporphyrin-III C-methyltransferase n=1 Tax=Aci... 109 7e-23 UniRef50_B9DNE0 Putative uroporphyrinogen III synthase n=1 Tax=S... 109 7e-23 UniRef50_A8UVV3 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogen... 109 1e-22 UniRef50_Q83H96 Porphyrin biosynthesis protein n=2 Tax=Tropherym... 108 1e-22 UniRef50_C7R377 Uroporphyrinogen III synthase HEM4 n=1 Tax=Jones... 108 1e-22 UniRef50_Q0ST17 Uroporphyrinogen-III methyltransferase/synthase ... 108 1e-22 UniRef50_Q1IWF9 Uroporphyrin-III methyltransferase and synthase ... 108 2e-22 UniRef50_C7I1F1 Bifunctional uroporphyrinogen-III synthetase/uro... 108 3e-22 UniRef50_D0LW22 Uroporphyrin-III C-methyltransferase n=1 Tax=Hal... 107 3e-22 UniRef50_C5EV70 Uroporphyrinogen-III methylase and Uroporphyrino... 107 4e-22 UniRef50_Q0W5T0 Uroporphyrinogen-III synthase n=1 Tax=uncultured... 107 5e-22 UniRef50_B3DZQ5 Uroporphyrinogen-III methylase and Uroporphyrino... 106 5e-22 UniRef50_A5KJC6 Putative uncharacterized protein n=4 Tax=Bacteri... 106 7e-22 UniRef50_B8DHJ3 Uroporphyrinogen-III synthase n=18 Tax=Listeria ... 106 9e-22 UniRef50_O67647 Putative uncharacterized protein n=1 Tax=Aquifex... 105 1e-21 UniRef50_C9M5W2 Porphyrin biosynthesis protein HemD n=1 Tax=Jonq... 105 1e-21 UniRef50_B0C6J8 Uroporphyrinogen-III synthase n=1 Tax=Acaryochlo... 105 2e-21 UniRef50_Q11DF2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chela... 104 2e-21 UniRef50_D2RRS2 Uroporphyrinogen III synthase HEM4 n=6 Tax=Halob... 104 2e-21 UniRef50_C9RPT4 Uroporphyrin-III C-methyltransferase n=1 Tax=Fib... 103 4e-21 UniRef50_B2SLZ9 Uroporphyrinogen-III synthase n=16 Tax=Xanthomon... 102 7e-21 UniRef50_Q3ACT2 Uroporphyrinogen-III synthase n=1 Tax=Carboxydot... 102 7e-21 UniRef50_UPI0001C35DE2 uroporphyrinogen III synthase/methyltrans... 102 1e-20 UniRef50_B9MRJ5 Uroporphyrin-III C-methyltransferase n=2 Tax=Clo... 101 2e-20 UniRef50_C2LYB7 Uroporphyrinogen-III synthase n=1 Tax=Staphyloco... 101 2e-20 UniRef50_D1B7N0 Uroporphyrin-III C-methyltransferase n=1 Tax=The... 100 4e-20 UniRef50_C8XF52 Uroporphyrinogen III synthase HEM4 n=1 Tax=Nakam... 100 4e-20 UniRef50_C3WG36 Uroporphyrinogen-III synthase n=17 Tax=Fusobacte... 100 4e-20 UniRef50_B3T2T9 Putative Uroporphyrinogen-III synthase HemD n=1 ... 100 5e-20 UniRef50_UPI000185083E uroporphyrinogen-III synthase n=1 Tax=Bac... 99 6e-20 UniRef50_B6R6Q3 Uroporphyrinogen-III synthase n=1 Tax=Pseudovibr... 99 1e-19 UniRef50_Q2J3D5 Uroporphyrinogen III synthase HEM4 n=14 Tax=Brad... 99 1e-19 UniRef50_C8NBV8 Putative uncharacterized protein n=1 Tax=Cardiob... 99 1e-19 UniRef50_Q18ES1 Uroporphyrinogen-III synthase n=6 Tax=Halobacter... 98 2e-19 UniRef50_A0B883 Uroporphyrinogen-III synthase / uroporphyrinogen... 98 2e-19 UniRef50_C2BTR7 Uroporphyrinogen-III synthase n=3 Tax=Mobiluncus... 98 2e-19 UniRef50_A9A1A3 Uroporphyrinogen III synthase HEM4 n=2 Tax=Thaum... 98 2e-19 UniRef50_B9YIB7 Bifunctional uroporphyrinogen-III C-methyltransf... 97 5e-19 UniRef50_D1Z2S3 Uroporphyrinogen-III synthase n=1 Tax=Methanocel... 96 7e-19 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 96 1e-18 >UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enterobacteriaceae RepID=HEM4_ECOLI Length = 246 Score = 321 bits (823), Expect = 1e-86, Method: Composition-based stats. Identities = 246/246 (100%), Positives = 246/246 (100%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobacteriaceae RepID=HEM4_SALTY Length = 246 Score = 302 bits (774), Expect = 8e-81, Method: Composition-based stats. Identities = 204/246 (82%), Positives = 217/246 (88%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE LVSRLR LGQVAW FPLIEF G++LP LAD+LA L E+DL+FALS Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFA +QL + R WP P YFAIGRTTALALHTVSG I YP DREISE LLQLPE Sbjct: 61 QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGREL+G+TLTARGAEV+FCECYQRCA HYDGAEEAMRW R VT Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGEMLQ+LWSL PQWYREHWLL CRLLVVSERLA LARELGWQDIKVADNADNDA Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacterium RepID=D0Z0U7_LISDA Length = 251 Score = 282 bits (722), Expect = 7e-75, Method: Composition-based stats. Identities = 116/246 (47%), Positives = 144/246 (58%), Gaps = 1/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRPSP GE+L +L +G H PL+ + G ++ L QL L D L A+S Sbjct: 1 MTILVTRPSPDGEQLAHQLCAVGLTVIHQPLLAITSGDEVDLLISQLNWLKSDDFLIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV A + L Q WP+ Y A+G TA L V+GQ +L PQ R SE LL LPE Sbjct: 61 DHAVKLAHNYLQSQGASWPKNVHYMAVGHKTAATLAKVTGQSVLMPQHRCDSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I +R LILRGNGGRELI L AR AEV +CE YQRC + DG A WQ ++V Sbjct: 121 LQQIRHRRVLILRGNGGRELIRQELIARHAEVHYCETYQRCWLPLDGTTLADSWQQQQVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGE L L L+PQ + W L+C L V S+R+A A +LG+ I +A N A Sbjct: 181 KLVVTSGEQLAFLHQLVPQ-HNHAWFLNCHLFVPSQRIADQASQLGFTHISTVGSASNQA 239 Query: 241 LLRALQ 246 L L Sbjct: 240 LFTFLS 245 >UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) RepID=C4K4E4_HAMD5 Length = 248 Score = 279 bits (714), Expect = 6e-74, Method: Composition-based stats. Identities = 119/245 (48%), Positives = 167/245 (68%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRPSP GEELV ++ G A+H+PLIEFS G+ L +L+ ++ + E D++F +S Sbjct: 1 MVVLVTRPSPMGEELVQFIQAHGHTAYHYPLIEFSQGRDLMELSQRITQMREEDMIFVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A+ + S WP Y+AIGR TA A ++ KI YP ++E SE LL L Sbjct: 61 KTAIDYLASFFKNNPLSWPPSIFYYAIGRNTAQAWQKINPFKIRYPLNQETSEGLLALAN 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I K ALILRGNGGREL+GD L RGA++ +CECYQR +HYDGA+++++WQ +V Sbjct: 121 LQFINKKTALILRGNGGRELLGDRLKKRGAQIIYCECYQRHPVHYDGAQKSIQWQRLKVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS EML ++++L+P+ R WL+ RL+VVS RLA +A LGW I++A+NA N++ Sbjct: 181 TVVVTSEEMLHRIYALVPEEARFAWLIKSRLIVVSARLANIATHLGWHHIQIAENASNES 240 Query: 241 LLRAL 245 LL + Sbjct: 241 LLHTV 245 >UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkalivibrio RepID=B8GSU7_THISH Length = 272 Score = 269 bits (687), Expect = 8e-71, Method: Composition-based stats. Identities = 84/244 (34%), Positives = 134/244 (54%), Gaps = 3/244 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ E + G V FP++E + +L + L D+ +S + Sbjct: 18 VLVTRPAHQAEVFCRMIEQAGGVPLRFPVLEILEPRDSGRLDALIDRLDAFDIAIFISPN 77 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV+ A +++H + R WP A+G+ +A L + P R SE LL+ PELQ Sbjct: 78 AVSMAVNRIHAR-RPWPEHLRIGAVGQKSAQELARAGHPAHICPPRRFDSEALLEEPELQ 136 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++AGKR +I RG+GGREL+GDTL RGA V + E Y+R D + + W E+ +V Sbjct: 137 DVAGKRIVIFRGDGGRELLGDTLKERGAVVEYAEAYRRGRPDADTGKLMIHWSRGELHLV 196 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIKVADNADNDAL 241 TS E L+ L+ ++ + R WL LLV + R+ + ARELG+ D VA++ ++++ Sbjct: 197 TSTSSEGLRNLFDMVGKLGR-MWLRKTPLLVGAPRMVETARELGFNGDPWVAEDPSDESM 255 Query: 242 LRAL 245 ++A+ Sbjct: 256 MQAV 259 >UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaproteobacteria RepID=Q491Z5_BLOPB Length = 249 Score = 268 bits (686), Expect = 1e-70, Method: Composition-based stats. Identities = 118/245 (48%), Positives = 159/245 (64%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRPSP GE+LV++L + G+ A+H PLI FS G++L L +L L E D L +S Sbjct: 1 MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHA+ +A +QL WP Y++IG T++ ++ +SG + YP +E SE LLQLPE Sbjct: 61 QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L GKRALILRGN GR ++ DTL RG V CECY R Y+ ++ + Sbjct: 121 LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTSGE+LQ L+ LIP+ YR WL+ C+L+VVS RLAKLAR LGW +I +A +A+N+ Sbjct: 181 TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI 240 Query: 241 LLRAL 245 L L Sbjct: 241 LFHLL 245 >UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MCU1_9PROT Length = 261 Score = 264 bits (674), Expect = 3e-69, Method: Composition-based stats. Identities = 79/245 (32%), Positives = 118/245 (48%), Gaps = 2/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ILVTRP L + G P++E + + L D + L E D +S Sbjct: 10 INILVTRPLHQSTFLAENIHASGGKPILLPVLEITDVTDITPLLDLINRLDEFDWAVFVS 69 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + + +Q R P A+G+ TA L ++L P + SE LL+ E Sbjct: 70 PNAVIKSMDLITKQ-RALPPDLKIAAVGKGTADTLRRYGVNRVLIPIEHFDSEALLKSEE 128 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN+ K +I RGNGGR L+GDTL RGA + + ECY R D A W ++ Sbjct: 129 LQNMTEKHVVIFRGNGGRALLGDTLAQRGAHIEYAECYLRRKPEIDSAPLLAAWSQGKIH 188 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E L L+ +I + L + +R+A+ ARELG + I A ++ Sbjct: 189 AVIITSSEGLHNLFDIIG-TLGQQLLKTTPIFTAHDRIAQAARELGLKKIVKVPYAGDEG 247 Query: 241 LLRAL 245 LL+ L Sbjct: 248 LLKGL 252 >UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Pasteurellaceae RepID=A6VL86_ACTSZ Length = 249 Score = 262 bits (670), Expect = 7e-69, Method: Composition-based stats. Identities = 97/247 (39%), Positives = 138/247 (55%), Gaps = 3/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP GE+L L G A H PL S G++L +L +++ L D +FA+S Sbjct: 1 MAVLVTRPDSRGEQLTEALNKAGVAALHMPLFSISAGRELNELPNKMYQLKAGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L +W + YFA+G+++A S Q + YP E SE LL LP+ Sbjct: 61 KNAVEFAAETLSNTGFRWRQDLIYFAVGQSSAEYFCEQSEQPVHYPYGHENSEGLLALPQ 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + K LILRGNGGREL RGA+V ECY+R + YD ++ Q + Sbjct: 121 MQRLTDKTVLILRGNGGRELFPAQAVRRGAQVEIIECYRRVPVEYDPKKQTDLCQRAGIN 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ--DIKVADNADN 238 ++ TS E+L +L + +P R+ WL CRL+ S R+AK A GWQ I +A ADN Sbjct: 181 TIIATSSEILTRLTNFVPAEERD-WLTQCRLVTASYRVAKSAERAGWQKRQILIAPRADN 239 Query: 239 DALLRAL 245 L++ L Sbjct: 240 ATLVKML 246 >UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobacillus flagellatus KT RepID=Q1GX91_METFK Length = 256 Score = 262 bits (670), Expect = 8e-69, Method: Composition-based stats. Identities = 86/245 (35%), Positives = 122/245 (49%), Gaps = 3/245 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I +TRP L S + G A FPLI +P Q L + D L +S + Sbjct: 9 IAITRPLDQATRLTSMIEAAGGHAIGFPLIAIAPLQDYSSFEQTLDEVTMQDWLIFISSN 68 Query: 63 AVAFAQSQLHQQDRKWPR-LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV A S+L + +WP P + AIG TA L +L P+ R SE LL LP++ Sbjct: 69 AVQHAMSRLQAKLPQWPPAKPQFAAIGPVTASQLMQYGITNVLQPEHRFDSESLLALPQM 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G R +I+RG GGREL+ DTL RGAEV F ECY+R D + W ++ Sbjct: 129 QAVKGLRIMIVRGVGGRELMADTLRDRGAEVRFAECYRRINPQADAGKLQSLWHNGQLDT 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +VVTS E ++ L ++ E WL + V R+A+L LG + +A +DA+ Sbjct: 189 IVVTSSEAMRNLLAMTGSGTAE-WLRDITICVNHARIAELPSSLGL-RVLIASAPGDDAM 246 Query: 242 LRALQ 246 ++ L Sbjct: 247 MQCLS 251 >UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio RepID=B5FF96_VIBFM Length = 253 Score = 261 bits (668), Expect = 1e-68, Method: Composition-based stats. Identities = 100/245 (40%), Positives = 135/245 (55%), Gaps = 2/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRP + L L G A PLI PG +L QL ++L + D + A+S Sbjct: 1 MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFSSLNDGDFIIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV + Q L Q +W + +Y A+G+ +A L + YP SE LL LP Sbjct: 61 QHAVEYTQKYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPT-HSDSEHLLALPV 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN GK+A+ILRGNGGR+LI L +VT+CE YQR AI +D + + WQ + V Sbjct: 120 LQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++VTSGE L S +W+L RLLV SER+ + A+ELG+Q I+ A N Sbjct: 180 TLIVTSGEQLSFFTSQFIS-TDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSD 238 Query: 241 LLRAL 245 LL + Sbjct: 239 LLHYI 243 >UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomonadaceae RepID=Q0AH88_NITEC Length = 260 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 83/248 (33%), Positives = 125/248 (50%), Gaps = 5/248 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 SIL+TRP L +R++ LG W FP++E S + L D +A L + DL +S Sbjct: 10 SILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSP 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV +H +R+WP +G+ +A AL ++ P+D SE LL++P+L Sbjct: 70 NAVERVMPLVHA-ERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQL 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + GKR +I RGNGGR+L+GDTL RGA V + ECY+R D W + Sbjct: 129 QIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKYWHDNGIQA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD---NADN 238 VV++S E L L+ +I + ++ L + +R+ ARELG + I Sbjct: 189 VVISSSEGLDNLFDMIGKTGQQ-LLRATAVFTAHDRIECKARELGIRKIYRTPLGDEGTV 247 Query: 239 DALLRALQ 246 LL + Sbjct: 248 QGLLEYFE 255 >UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methylophilaceae RepID=C6X7P0_METSD Length = 267 Score = 255 bits (653), Expect = 8e-67, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 126/246 (51%), Gaps = 2/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 +S+ +TRP L + G + FPLIE +P QL LG+ D +S Sbjct: 14 LSVAITRPLDQATRLSRLIVEAGGTPYGFPLIEIAPLADYSAFDAQLHELGKYDWTIFIS 73 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV A ++ + P + AIG TA L ++ +L PQ R SE LL LPE Sbjct: 74 SNAVQNAIPRMLNLVGQPPATLRHAAIGPVTAAELTSLGIGPVLTPQGRYDSESLLALPE 133 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + G+R LI RG GGREL+ ++L ARGA V F ECY+R RWQ +++ Sbjct: 134 MQQVKGQRFLIFRGVGGRELLAESLRARGATVDFAECYRRINPQTSAEPLEQRWQQQQLD 193 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS E ++ L ++ + W+ L V R+A+L ELG + VA+ +DA Sbjct: 194 AVVVTSSEAMRHLLNMT-NNGQHAWIRDVTLCVNHARIAELPIELGL-HVIVAEAPGDDA 251 Query: 241 LLRALQ 246 +L+ L Sbjct: 252 MLQCLN 257 >UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 Tax=Moritella sp. PE36 RepID=A6F8Y8_9GAMM Length = 255 Score = 255 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 92/248 (37%), Positives = 137/248 (55%), Gaps = 4/248 (1%) Query: 1 MSI--LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 M I L+TRP GE+L ++ A P I+ S GQQ +++ LA L D + A Sbjct: 1 MKIRALITRPRVKGEQLARQIEAADGAALCCPFIDISAGQQFTKVSSLLAELQPDDYIIA 60 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S +AV +A + L +R WP+ +Y A+G TTAL+ P D SE +L+L Sbjct: 61 ISDNAVNYANTSLINANRTWPQQINYIAVGPTTALSWQKYGINHAQIP-DTHDSEGVLKL 119 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 ++ K+ +ILRGNGGRE + + LT R A VT+CE YQR A YD +WQ Sbjct: 120 LANASVEHKKIVILRGNGGRETLAEDLTKRTANVTYCEVYQRTAPDYDPDMLINKWQQFA 179 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + V++TSGE+L L IP + W+L+ +V S+R+A LA LG + + +A A N Sbjct: 180 INSVIITSGEILGNLIKTIP-YTALPWILNLHFIVPSQRIAALAHTLGIEHVTIATGASN 238 Query: 239 DALLRALQ 246 ++L A++ Sbjct: 239 NSLFNAIK 246 >UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrionales RepID=B7VME0_VIBSL Length = 242 Score = 252 bits (644), Expect = 8e-66, Method: Composition-based stats. Identities = 100/246 (40%), Positives = 138/246 (56%), Gaps = 5/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G+ L +L G A H PLI P +D L SD++ A+S Sbjct: 1 MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIV---DNPHSSDLSTQLNNSDIIIAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV AQ+ L + WP P Y +G+ TA L VS QK+ YP+ SE LL+L E Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPK-VSDSEHLLKLTE 116 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + K LILRGNGGRELI D+L RGA+V++CE Y+R I + W ++ + Sbjct: 117 LNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKTS 176 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV+TS E L+ L S+ P Y WL +L V S+R+ + A++LG+ ++ +A N Sbjct: 177 KVVITSQEQLEYLCSITPDEYLA-WLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQI 235 Query: 241 LLRALQ 246 LL ALQ Sbjct: 236 LLAALQ 241 >UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BL64_9GAMM Length = 260 Score = 249 bits (636), Expect = 6e-65, Method: Composition-based stats. Identities = 75/252 (29%), Positives = 124/252 (49%), Gaps = 8/252 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ----LADQLAALGESDLL 56 + +LVTRP+ + L L G FPL++ +P L Q+ L + Sbjct: 8 LRVLVTRPAHQADTLYELLLQQGADPVRFPLLQITPVTSADSGFHLLKQQIIDLDLFQHI 67 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +S +AV + Q + P + AIG+ +A L+ P SE LL Sbjct: 68 IFISPNAVELGYEWIDQYWPQLPLGVQWLAIGKQSAARLNNYGIDAYHSP-LGYDSEALL 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 P LQ IAG + LI+RG GGRE + + L ARGAEV++ E Y+R + Y E + + Sbjct: 127 NSPALQKIAGDKVLIMRGEGGRETLAEELRARGAEVSYAELYRRESPCYSAKEISDALLS 186 Query: 177 REVTMVVVTSGEMLQQLWSLI---PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + + ++++SG L+ L +L+ + LL+C L+V S+R+ + A+ +G+ I A Sbjct: 187 KHLDAILISSGAGLKNLITLLSSTGKELSTDSLLNCHLIVPSDRIKQEAQGVGFNRITTA 246 Query: 234 DNADNDALLRAL 245 D+ +++ AL Sbjct: 247 SGPDDRSMIAAL 258 >UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurellaceae RepID=B8F5M2_HAEPS Length = 252 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 94/247 (38%), Positives = 132/247 (53%), Gaps = 3/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G +LV L A H PL G LP L L+ L D +FA+S Sbjct: 1 MNVLVTRPDQRGLQLVEMLAEQQIFAIHQPLFRVEAGADLPTLPSSLSRLNSGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L Q W YFA+G+ +A + Q + YP E SE LL LPE Sbjct: 61 KNAVDFATETLKQTGFYWRSDLLYFAVGQRSANHFASQIEQAVRYPIQSENSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + ++GK LILR + GRE + T+RGAEV ECY+R + + +E+ + Sbjct: 121 MAQLSGKNVLILRADTGREFFAEQATSRGAEVQILECYRRIMLADNLSEQISLAKRAGTD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ--DIKVADNADN 238 +VVTSGE+L + WL CRL+VV +R+A LAR+ GW+ I+++ ADN Sbjct: 181 TIVVTSGEILTTFIEQTAEADLP-WLYQCRLIVVGKRIATLARKSGWKSEQIQISMKADN 239 Query: 239 DALLRAL 245 +LL + Sbjct: 240 HSLLETI 246 >UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiobacillus RepID=B5ERN5_ACIF5 Length = 262 Score = 246 bits (629), Expect = 4e-64, Method: Composition-based stats. Identities = 77/243 (31%), Positives = 114/243 (46%), Gaps = 2/243 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTRP E+++ L G FP +E + L D L L D + S++ Sbjct: 11 IVVTRPRAQTGEMLTLLEAQGARPILFPAVEIEAPENWQSLDDALHRLVTYDWVIFSSRN 70 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AVAFA S+L ++ WP P A+GR TA AL Q L P+ R SE LL+ PEL Sbjct: 71 AVAFALSRLQSRNLSWPVGPRIAAVGRETAKALGEFGLQVDLVPR-RFSSEGLLESPELL 129 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R + G+ GREL+ TL RGA CY+R + W E+ V Sbjct: 130 DVRGQRIALFAGDQGRELLEKTLDERGAVTDEVLCYRRRLPGTNPTPLLHAWARGELDAV 189 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 VTS E+ + ++ + WL + ++ +S A+ +G +A A +L Sbjct: 190 TVTSPEIFNNFYQMVG-GLGQRWLKNTPIIAISPLTAEAVTAVGLPTPWIAPEASTAGML 248 Query: 243 RAL 245 AL Sbjct: 249 AAL 251 >UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio RepID=A5F4J2_VIBC3 Length = 260 Score = 245 bits (626), Expect = 9e-64, Method: Composition-based stats. Identities = 98/245 (40%), Positives = 129/245 (52%), Gaps = 5/245 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G EL L G A H PL+ S QL LA+ L D++ A+S Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAE---DLSSFDIIIAVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV F+ L + WP Y A+G+ TA Q + YP+ SE LL L Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEIS-DSEHLLALSM 121 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L+++AGK+ LILRGNGGRELI TL RGA V + E Y R + AE +WQ +V Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+TS E L + W+ LLV S+R+A LA +LG+ I V +A N Sbjct: 182 SLVITSSEQLAFFIRQF-ETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAANRD 240 Query: 241 LLRAL 245 L+ AL Sbjct: 241 LVAAL 245 >UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thauera sp. MZ1T RepID=C4ZNN4_THASP Length = 267 Score = 238 bits (609), Expect = 9e-62, Method: Composition-based stats. Identities = 73/247 (29%), Positives = 114/247 (46%), Gaps = 5/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++V RP E L +RL G A FP+I P L + L E DL F +S Sbjct: 20 TLVVMRPREQAESLCARLEAAGGRALRFPVIAVGPALDPAPLQAIVGRLDEFDLAFFVSP 79 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV A + Q R WP +G+ + + ++ PQD SE ++ LPE Sbjct: 80 NAVDHAMRAILPQ-RTWPARLRVATVGKGSQRVMQDWGFANVIAPQDGFDSEAVIALPEF 138 Query: 122 QN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G++ LI RG+GGREL+ DTL RGA V + CY+R D A E+ Sbjct: 139 AADAVRGRKVLIFRGDGGRELLADTLRERGASVEYVTCYRRHCPEADPALLLGPAARGEL 198 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++TS E ++ L ++ L + R+ AR G++ + A +D Sbjct: 199 DGLLLTSSEGVRNLEWMLGTEGLAA-LHAVTVFATHPRIVAQARAAGFERVVETP-AGDD 256 Query: 240 ALLRALQ 246 L++AL+ Sbjct: 257 GLMQALE 263 >UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0I363_VIBHO Length = 257 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 95/246 (38%), Positives = 124/246 (50%), Gaps = 2/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LV RP+PA ELV L G A PL+ FS G+ LP L + L ++ A+S Sbjct: 1 MTVLVVRPAPACYELVETLNQSGIKALPAPLLSFSEGKDLPVLTNTYRRLPSGSVVVAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A+ + Q Q + W Y A+G TA SG L P E SE +L L Sbjct: 61 PRAIEYTQQQFRNDNTAWRDDLHYVAVGEKTAQVWLEESGINALQPP-TEDSEGMLSLSV 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LILRGNGGR L+G TL +RGA+V + E YQR AM+WQA V Sbjct: 120 FGEPEHLEVLILRGNGGRALLGKTLASRGAKVHYFEAYQRHWTSDSLLSLAMQWQAENVD 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGE L L I + + WL C +LV S+R+ A LG+ I+ ++A N A Sbjct: 180 TLVVTSGEQLSLLCQTISES-NQQWLRECHILVPSKRIYNQAIGLGFNTIRCVNSASNTA 238 Query: 241 LLRALQ 246 L AL Sbjct: 239 LFHALN 244 >UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shewanella RepID=A4YBG3_SHEPC Length = 246 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 83/248 (33%), Positives = 124/248 (50%), Gaps = 5/248 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +L+TRP + +V L G + PL+ P + D L +D++ +S Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGITHYVTPLLGVEPTNDIT--TDASHPLAGTDIIICIS 58 Query: 61 QHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV FA L++ + + P YFA+G T AL + + P D + +E LL L Sbjct: 59 ANAVIFANKALNKINAQIATWPKVQYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLTL 118 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 LQ+I K+ I+RG GGRE + + LT RGA V + E YQR DG +WQ Sbjct: 119 ASLQHIPAKKVTIIRGVGGREALAEQLTRRGANVRYWEVYQRVCPPLDGYAITQQWQHFG 178 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + +VVTSGE+L L L+P+ WL C ++V S R+ A G + A A++ Sbjct: 179 IDTIVVTSGEVLNNLIKLVPKELF-AWLRSCHIIVPSNRVEAQAHAFGINHVTNACAANS 237 Query: 239 DALLRALQ 246 A+L AL+ Sbjct: 238 KAVLNALK 245 >UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase n=1 Tax=Methylococcus capsulatus RepID=Q602K2_METCA Length = 672 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 128/246 (52%), Gaps = 3/246 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP E L + T G A FPL++ P Q + A L + D +S Sbjct: 1 MRVLVTRPKEQAEPLCRLIETAGGKAVRFPLLDIEPSAQAEEGAALLRQASDWDWWIFVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV A + R P AIG+ TA AL L P+ + SE LL+ P Sbjct: 61 VNAVNRA--RALDVLRPDGAGPRIAAIGKATADALVDGGIAVDLVPESQANSEGLLETPP 118 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++++AG+R LI+RG GGRE + + L RGA V + E Y+R +H + + Sbjct: 119 MRDVAGRRILIVRGEGGRETLKERLVERGALVQYAELYRRVPVHTGAEALIEGLRTAGLD 178 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 M+ TSGE ++ L+ L+P R L+ L+V+SERL A LG++ +KVAD A + A Sbjct: 179 MLTATSGEAIEHLYRLVPPEDRPR-LVETPLVVISERLKNQAGSLGFRHVKVADAASDAA 237 Query: 241 LLRALQ 246 +L+AL+ Sbjct: 238 VLQALE 243 >UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5J5_CHRVI Length = 251 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 98/243 (40%), Positives = 135/243 (55%), Gaps = 7/243 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ E L + + G A FP I P P+ LA DLL+ +S + Sbjct: 12 VLVTRPAGQAEPLCRLIESAGGRAIRFPTIAIEPTHD-PEATALLAE--SWDLLYFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV AQ+ + D WPR+ A+GR TA AL L P DR SE LL++PEL Sbjct: 69 AVEQAQALVA--DGTWPRVERVAAVGRGTARALEAAGRAPDLVPNDRYESEALLEMPELS 126 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R LI+RG GGR L ++ RGAEV F E Y+R D A W+ EV V Sbjct: 127 DMRGRRVLIVRGVGGRGLFAQAMSERGAEVRFAEVYRRARPAVDVAPLLAHWRE-EVDFV 185 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 + TS E+L L L+ Q + LL L+V++ER A+ AR LG+Q I+VA+ AD+ +++ Sbjct: 186 MATSDEVLLNLAELLGQEGQAS-LLATPLVVIAERTAQTARNLGFQTIRVAERADDSSIV 244 Query: 243 RAL 245 RAL Sbjct: 245 RAL 247 >UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Gallionella ferruginea ES-2 RepID=C5V3N2_9PROT Length = 248 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 82/246 (33%), Positives = 124/246 (50%), Gaps = 15/246 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +LVTRP L + G A FP++E +P L +L +Q++ + +++L +S Sbjct: 9 LKVLVTRPRDQAFTLAQAIGQQGGTAVLFPMLEIAPVPDLLRLQEQVSHVEQANLAIFIS 68 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + + K P +G +A AL + ++ P +R SE LL PE Sbjct: 69 PNAVKYG---MAATGGKVPA--RVATVGEGSAKALRALGIAHVIVPVERFDSEGLLARPE 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNI G +I RG+GGREL+GDTL RGA V + CY RC +E A V Sbjct: 124 LQNIDGWHVMIFRGDGGRELLGDTLRERGARVEYVTCYLRCKPQCPVSELA------GVD 177 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ VTS E L L +I + L V+ R+A+LA+ LGW + + ++ +D Sbjct: 178 LITVTSSEALNHLSQMI---VDSKEVFDRPLFVIHPRIAELAKRLGWSKVHLTES-GDDG 233 Query: 241 LLRALQ 246 LL LQ Sbjct: 234 LLAGLQ 239 >UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456_AZOSB Length = 265 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 68/245 (27%), Positives = 107/245 (43%), Gaps = 5/245 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + VTRP L +R G FP++ + L + +A L DL F +S + Sbjct: 19 VAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPN 78 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV A + + + R WP + +G+ + AL ++ P + SE +L LP Sbjct: 79 AVEHALAAVKAR-RHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFS 137 Query: 123 N--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 I G+R +I RG+GGREL+ D L ARGA V CY+R D A + Sbjct: 138 ATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLD 197 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+TS E ++ L ++ + L + R+ AR G+ ++ +D Sbjct: 198 ALVLTSSEGVRNLVEMVGEKGFGV-LRRVTVFAPHPRIVAHARAAGFDRVEETP-PGDDG 255 Query: 241 LLRAL 245 LL L Sbjct: 256 LLETL 260 >UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteobacteria RepID=Q479S9_DECAR Length = 260 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 78/246 (31%), Positives = 116/246 (47%), Gaps = 5/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP L + G FPL+E SP L + +A L L +S Sbjct: 11 TIVVTRPQAQAAPLAEAIAAAGGKPLVFPLLEISPATDPQPLIEAVARLESYSLAVFISP 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV A + WP A+G+ TA L + P +R SE LL+LPE+ Sbjct: 71 NAVDHALPAILAHG-GWPVSLKPAAVGQGTARELAAKGVFGCVVPSERFDSEALLELPEM 129 Query: 122 --QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 +++ G+R +I RG+GGREL+ DTL RGA V CY+R WQ+ ++ Sbjct: 130 AAESVNGRRVVIFRGDGGRELLADTLRERGASVDCITCYRRSGPSAGVQPLLAAWQSGQL 189 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + V+S E L+ L + R +L L V R+A+ AR LG +I + + A + Sbjct: 190 DALTVSSSEGLRYLVDRLDAEGR-AFLQKTPLFVPHARIAENARALGLSNIILTEAA-DA 247 Query: 240 ALLRAL 245 +L L Sbjct: 248 GILAGL 253 >UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W1_WIGBR Length = 245 Score = 232 bits (592), Expect = 8e-60, Method: Composition-based stats. Identities = 89/245 (36%), Positives = 149/245 (60%), Gaps = 1/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRP P G+ L++ +R G+ AW+ PLI F+ G L L + L E D++ +LS Sbjct: 1 MTILITRPYPHGQHLINMIRKNGKEAWYLPLIYFTSGIGLLSLTNFFKKLQEKDIICSLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A +A Q+ + WP+ +Y+AIG+T+A L S K++YP+ E SE LL L Sbjct: 61 PRATKYANYQILLEKCNWPKKINYYAIGKTSAFYLSKYSKCKVIYPKLTENSENLLDLIS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +++ K+ LIL+GN GR+ + + L GA + ECY+R I Y+ + + ++ Sbjct: 121 KEDVK-KKILILKGNNGRKFLENKLKLYGAYIINVECYKRNFIKYNKYDYLKKIINLKIN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTS E+L QL + IP Y +L++ +L+VVS+R++ +A LGW++I V+ ++ N Sbjct: 180 TLVVTSSEILHQLHNNIPLNYINFFLINFKLVVVSKRISDIADNLGWKNIIVSKSSKNKD 239 Query: 241 LLRAL 245 ++++L Sbjct: 240 IIQSL 244 >UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggiatoa sp. PS RepID=A7BY77_9GAMM Length = 271 Score = 230 bits (588), Expect = 2e-59, Method: Composition-based stats. Identities = 79/269 (29%), Positives = 122/269 (45%), Gaps = 33/269 (12%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + ILVTRP+ E L + G + P+IE + L D L E D+ +S Sbjct: 6 IKILVTRPAHQAEHLCQLIEAEGGQSIRLPVIEIIDIEDKTALFDCRMHLDELDIAIFIS 65 Query: 61 QHAVAFAQSQLHQQD--------------------RKWPRLPDYFAIGRTTALALHTVSG 100 +AV + L + ++ + A+G+ T L Sbjct: 66 ANAVDKSLPTLLTPNHSENEKDSLTPVSTNSTTYFQREEQTLQIIAVGKRTTSTLKAWG- 124 Query: 101 QKILYPQDREISEVLLQLPELQN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECY 158 L P SE +L++P++Q + GK+ +I RG GGREL+ +TL RGA V + Y Sbjct: 125 LTALCPDSPFNSEAVLKMPQMQTEVVQGKKIVIFRGEGGRELLAETLQQRGAIVNYINVY 184 Query: 159 QRCAIHYDGAEEAMRWQAR-EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSER 217 +R +W A V ++ VTS E LQ L++++ + WL H +V+SER Sbjct: 185 RRIQPSVP------KWIADISVDVITVTSIEGLQNLFAMLEKQV--AWLCHTPFVVMSER 236 Query: 218 LAKLARELGWQ-DIKVADNADNDALLRAL 245 + A++LG Q I VA A +D LL A+ Sbjct: 237 IRTEAQKLGVQAPIFVAPTASDDGLLTAI 265 >UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0Y9F1_9GAMM Length = 264 Score = 230 bits (586), Expect = 4e-59, Method: Composition-based stats. Identities = 71/251 (28%), Positives = 118/251 (47%), Gaps = 12/251 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS-----PGQQLPQLADQLAALGESDLLF 57 +LVTRP +LV+ + T G A H P+I + + Q AL + + Sbjct: 9 VLVTRPQGQAADLVAAIETAGGCAIHCPVIAIERLSDSDTAEQQRCKQQFMALDQFQHVI 68 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLL 116 +S +AV + + Q + P +++ IG +T L + SE LL Sbjct: 69 FISTNAVKYGLQWIDQYWPQLPVGINWYGIGGSTTQLLRQEGVPVNDTVECGTMNSEALL 128 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 Q LQ + ++ LI+RG GGR+ + L RGAEV + ECY+R + + + Sbjct: 129 QHKGLQAFSHQKVLIVRGVGGRDYLQQVLQQRGAEVEYAECYRRR-VAVTSTDLISKIVE 187 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHW--LLHCRLLVVSERLAKLARELGWQDIKVAD 234 E+ V + SGE ++ L+ EHW + L+V R+A++A + G++ + AD Sbjct: 188 YEINTVCLNSGESVENFCQLVGP---EHWSIIKGLLLVVPGARVAEIAGKKGFERVFCAD 244 Query: 235 NADNDALLRAL 245 NA N A++ A+ Sbjct: 245 NASNQAMIAAI 255 >UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococcus oceani RepID=Q3JDS0_NITOC Length = 265 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 74/245 (30%), Positives = 115/245 (46%), Gaps = 3/245 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP+ E+L + G A FP +E + + + + L + +S Sbjct: 16 RVLVTRPAEQAEKLSQAIELEGGQAVRFPTVEIGDSEVPAVVEEIIGRLDDFHWAVFVSA 75 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + + R+ P +GR TA AL L P SE LL + EL Sbjct: 76 NAVQRGVPWVFAR-REMPANLKIAVVGRATAQALGNFGLYPRLCPSYGYNSEALLAMDEL 134 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD-GAEEAMRWQAREVT 180 Q++ G++ ++ R +GGREL+ TLT RGA+V + E Y+RC A V Sbjct: 135 QDMKGQQVVLFRASGGRELLAKTLTKRGAKVEYAEVYRRCLPSPSVAANLRQVLVNVPVD 194 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+ TS +L+ L L + E L L+V+ R + ARELG+ I VA + A Sbjct: 195 VVITTSKAVLENLCHLAGEPLLEK-LRRTPLVVIGSRQVQQARELGFTQIWVAQEPSDAA 253 Query: 241 LLRAL 245 L++ + Sbjct: 254 LVQTI 258 >UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RC73_LEGLO Length = 252 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 68/232 (29%), Positives = 106/232 (45%), Gaps = 4/232 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP +L +R G +A P +E D L L +S Sbjct: 8 LRILNTRPQEQAHKLTESIRASGGIAIELPALEIQASNS--DWVDLLPNLDNVTHAIFIS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +QL+Q WP AIG+ TA +L + Q P+ SE LL L Sbjct: 66 ANAVHYCFTQLNQLQINWPTSIQVIAIGQGTASSLQKFNIQVSAIPEFP-NSEHLLSLDT 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ + L+ +G GR LI + L +GA++ + YQR W+ V Sbjct: 125 LQHLENQNVLLFKGKEGRPLIEEQLMQKGAKLVILKVYQRVMPKPSPLLVQSIWRDDLVD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 ++++TS + L L+ + + WL R LV+SER+A++A LG I + Sbjct: 185 IILLTSEQSLLNLFKIFDKE-AHDWLKSKRWLVISERIAQIASSLGIHKINI 235 >UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas RepID=A0KFH5_AERHH Length = 244 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 102/246 (41%), Positives = 136/246 (55%), Gaps = 7/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M LV RP+ EL + LR G PL+E G +L +L + L ++D++ A+S Sbjct: 1 MIPLVVRPAAQAAELAALLRQHGHAPLCCPLLETVAGSELHRLPEL---LPQADIVIAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV F L Q + WP DYFA+G+ +A A V Q L P D SE LL LP Sbjct: 58 VHAVNFTHHFLLQTGQTWPN-IDYFAVGQASADAFSEVGIQ-ALSPDDPR-SEGLLALPS 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ + GK+ LILRGNGGR+LI TL +RGA V +C Y+R DG WQA + Sbjct: 115 LQQVNGKQVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPALDGDALTCHWQAAGLD 174 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++VTSGE+LQ+L L+P WL L+V S R+A++A G+ I +A A N A Sbjct: 175 SLLVTSGELLQRLLELVPDQQLP-WLHDRLLVVPSPRVAEMAAAAGFTHITIAQGASNQA 233 Query: 241 LLRALQ 246 L AL+ Sbjct: 234 LTAALE 239 >UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N2Y5_9GAMM Length = 250 Score = 221 bits (564), Expect = 2e-56, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 114/244 (46%), Gaps = 9/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP ++L + G FP+I +P L ++ L +S+ Sbjct: 11 KILITRPRQQSDQLAELIEQAGGKPILFPVIAINPLL-PSDWQQPAFKLDHANWLIFVSR 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV S + P+ + A+G TA A+ + P+ SE LL +PE+ Sbjct: 70 NAVLSFMSGWQ---TELPKHLKFAAVGGGTAQAMRESGLKVDCQPEISSGSEGLLMMPEM 126 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q++A + +I+RG GGRE + DTL +RGA +++ E Y+R D A Sbjct: 127 QDVADCKIIIIRGVGGREHLADTLASRGASISYMEVYRRDVAVQDKVSIERAMAA---DK 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ TS + + ++ LL+ L+VVS R+ A G+ ++V+ +A + A+ Sbjct: 184 LICTSVAGIDNVCQILSD--DMTNLLNKPLVVVSNRIKAHAESKGFSCVRVSTDASDVAM 241 Query: 242 LRAL 245 L+ L Sbjct: 242 LQTL 245 >UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAH2_BREBN Length = 270 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 100/244 (40%), Gaps = 2/244 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR ELV ++ LG A+ FPL++ P +L + + L D + S + Sbjct: 15 IMVTRARSQVRELVEQIERLGGEAYAFPLLKMMPPTDTAKLDEAITQLPAFDWVVFTSVN 74 Query: 63 AVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V F ++ + A+G TA AL + + P D ++E LL Sbjct: 75 GVRFFLERMREVGVGLEAFTGKIAAVGPKTAKALEHHGLEVAVIPSD-YVAEGLLSSLYD 133 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G+R L+ R + R+ + L G VT + Y E A + Q + + Sbjct: 134 QLLPGQRVLLPRADIARKALPKELARLGLAVTEVDVYHTVIDAEHAPEAAEKLQQGLIDI 193 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ TS + + + + WL H ++ + A A++ G VA + L Sbjct: 194 ILFTSSSTVTHFMAAMEPYASLDWLKHVQIACIGPITADTAKQNGLSVHAVASEYTVEGL 253 Query: 242 LRAL 245 L A+ Sbjct: 254 LAAI 257 Score = 45.6 bits (107), Expect = 0.001, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 40/130 (30%), Gaps = 7/130 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 +L+ R A + L L LG + + + L + D++ Sbjct: 140 RVLLPRADIARKALPKELARLGLAVTEVDV--YHTVIDAEHAPEAAEKLQQGLIDIILFT 197 Query: 60 SQHAVAFAQSQLHQ-QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 S V + + W + IG TA +G + E LL Sbjct: 198 SSSTVTHFMAAMEPYASLDWLKHVQIACIGPITADT-AKQNGLSVHAVASEYTVEGLLAA 256 Query: 119 PELQNIAGKR 128 ++N+ G R Sbjct: 257 I-IENLGGNR 265 >UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6B4_9GAMM Length = 253 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 72/248 (29%), Positives = 124/248 (50%), Gaps = 10/248 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFALSQ 61 IL+TRP P R +T G + P+IE + + + L D + +S+ Sbjct: 8 ILITRPEPENTLSCERFQTWGAHSLSLPMIEIDALTEQNAAIQSHIFDLDLYDQVIFISK 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDR----EISEVLLQ 117 +AV + + P ++ IG+ T ++ + + Q+ SE LL Sbjct: 68 NAVRYGIEWIEDCWPMLPVGINWVGIGKGTTDFINELGFDLGIKAQEHALSGNTSEALLN 127 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 +Q +AG++ LI+ G GGR + +TL RGA+V Y R I+YD + A A Sbjct: 128 QESMQKVAGQKILIMGGEGGRTKLAETLLERGAQVKHLALYSRNKINYDLEQVAE---AE 184 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++++TSGE L+ L + Q + ++WL H +L S+R+A +A ELGW+++ A+ AD Sbjct: 185 NCEVILITSGEGLENLVDTLSQ-HNKNWL-HKLILTPSQRVADMAIELGWKNVVNANGAD 242 Query: 238 NDALLRAL 245 ++++ AL Sbjct: 243 DNSIYAAL 250 >UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N607_9GAMM Length = 251 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 70/245 (28%), Positives = 104/245 (42%), Gaps = 8/245 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L TRP E L + +R V P + L L + D +S Sbjct: 8 LRVLNTRPQGQAELLSNAIRAADGVVLELPTLAIEATPDWLS---TLPDLKKVDQAIFVS 64 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV +QL Q +WP AIG+ A AL + P+ SE LL L Sbjct: 65 ANAVEQCFTQLQQAGFRWPATIRVIAIGQGCAAALKKFNIPIHAMPEIA-DSEHLLTLSS 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + LI +G GGR LI +TL +G + YQR + W+ V Sbjct: 124 LLQPQKQNILIFKGAGGRALIEETLLNKGVNLLALNVYQRVMPKINHQFVKSIWRDDLVD 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++++TS + + L+ L + HWL LV+SERLA++A LG I + D Sbjct: 184 IILLTSEQSMHHLFKLFEK-DAHHWLRQKTCLVISERLAQIASSLGMSTII---RSHPDG 239 Query: 241 LLRAL 245 ++ AL Sbjct: 240 MMNAL 244 >UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionella pneumophila RepID=Q5X1F1_LEGPA Length = 250 Score = 219 bits (559), Expect = 6e-56, Method: Composition-based stats. Identities = 60/233 (25%), Positives = 107/233 (45%), Gaps = 4/233 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP + L ++ G + P +E + + L L + +S Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENN--WINNLPDLTSVNQAIFVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +L ++ W AIG+ T+ L+ + Q P+ SE LL L Sbjct: 66 ANAVRYFMMELASKNINWLNSIRVAAIGKGTSRVLNEFNIQVSDVPELP-DSEHLLTLNS 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I + L+++G GGR+LI + L +GA++ Y+R D W+ Sbjct: 125 LQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDQEFLNSLWRDDLAD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 ++++TS + + L+ + + WL + LV+S+RLAK+A G + I ++ Sbjct: 185 IILLTSEQSIHNLFKMF-SIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236 >UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolumonas auensis DSM 9187 RepID=C4LDV5_TOLAT Length = 241 Score = 219 bits (558), Expect = 8e-56, Method: Composition-based stats. Identities = 95/246 (38%), Positives = 133/246 (54%), Gaps = 6/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ L+ RP PA EL + LR G PL+ + PG +L L L ++++ A+S Sbjct: 1 MTPLILRPQPAAGELAAYLRRDGHTPVVCPLLTYQPGDELALLPAL---LKQAEITLAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV FA L QQ WP Y A+G TA + ++ P D SE LL P Sbjct: 58 AAAVQFASRHLQQQKILWPPALTYLAVGPATAAEWQQQGLR-VISPADAR-SEGLLAQPA 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ GK+ +ILRGNGGREL+ +TL RGA+V+ ECY+R + DGA WQA V Sbjct: 116 LQSVNGKKIVILRGNGGRELLTETLRHRGAQVSCVECYRRHYLQTDGARLLQEWQAAAVD 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E+ +QL L+P +WL R V SER+A+ R G++ I + A + A Sbjct: 176 SVIITSSELFRQLLILLPDTAG-NWLSALRWFVASERIAEEIRHSGFKQITIMSGAQHQA 234 Query: 241 LLRALQ 246 + AL Sbjct: 235 VAAALS 240 >UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS89_9GAMM Length = 267 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 84/246 (34%), Positives = 115/246 (46%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP+ E L G A PL+ S + P A A L DLL S Sbjct: 17 NIVVTRPAHQAESFCRMLEHAGANALRCPLLNISATPKTPSFARLRAELASFDLLIFNSP 76 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A F QL Q R R+ AIG TA A+ + + P SE LL+LP L Sbjct: 77 NAANFGLPQLEPQRRLQGRV-KIAAIGAKTAHAIAGLGYSVDIVPATGFDSESLLELPIL 135 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE-VT 180 + + G + ILRG+GGREL G L +RGAEV++ + Y+R + E+ + Sbjct: 136 EKVGGMKIAILRGSGGRELAGSVLRSRGAEVSYIQVYERQPPSKEQFEQIEQLLLHNRSD 195 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW-QDIKVADNADND 239 V +TSGE LWS I H L + S R+A +AR G I VA + ++ Sbjct: 196 AVAITSGEAFLALWSGIGPRL-CHLLNQSTFVFGSRRIADVARSKGLCSPIAVAADPSDE 254 Query: 240 ALLRAL 245 A+ AL Sbjct: 255 AMFAAL 260 >UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marinomonas sp. MWYL1 RepID=A6W1B5_MARMS Length = 250 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 115/248 (46%), Gaps = 10/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQL---PQLADQLAALGESDLLFA 58 IL+TRP P R+R G VA P++E P + + + Q+ + D + Sbjct: 5 RILITRPEPENSLSRERVRAYGWVAVPLPMLEIKPVEDVNKKATIRAQIFDIDTFDYVIF 64 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S++A A L + P + IG+ T L I P +E LL+ Sbjct: 65 VSKNAARLACDWLDECWPMIPTNVHWIGIGQGTTQTLLNEGIPAISNP--GHTTETLLEW 122 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + ++ LI+RG GGR + + L RGA+V++ Y R Y + + Sbjct: 123 LKPAKMKDQKVLIIRGEGGRPELANKLEERGAKVSYLSLYDRKKPIYYAQTF---FMLPD 179 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + ++ +TSGE L+ L + ++ W +L S R+ + A+E+GW + A+ AD+ Sbjct: 180 INLIWITSGESLRNLSEYV-SLHKPEW-KTLPILTPSIRVNQQAKEMGWINASCANGADD 237 Query: 239 DALLRALQ 246 ++L++A + Sbjct: 238 NSLIKATE 245 >UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanella marisrubri RepID=Q1MZM6_9GAMM Length = 255 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 78/252 (30%), Positives = 122/252 (48%), Gaps = 12/252 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP-----GQQLPQLADQLAALGESDLL 56 S+LVTRP G+ ++ L G H PL++ P G QL ++ L D + Sbjct: 3 SLLVTRPQGQGQGMMIELEQAGIQVVHQPLLKIEPLKMEDGADYHQLKQRIVDLDLYDTV 62 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTV--SGQKILYPQDREISEV 114 +S +A A + Q + P +FA+G ++A L + S + + SE Sbjct: 63 ICVSSNAAQLASDWIDQYWPQLPVKQQWFAVGPSSAEPLLPLLDSAAMDIQVPEGNHSEG 122 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 LL LP+L+++ K+ LILRG GGRELI TL RGA V + E Y+R + + Sbjct: 123 LLALPQLRDMTEKKVLILRGVGGRELIKSTLEERGASVHYAEFYRRTPVDLTQQQLQTLL 182 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++ ++TSGEM+QQ +P LLV SER+ K+A +LG+Q + Sbjct: 183 TEHQIHYALLTSGEMVQQFHQALPNTP-----KDLHLLVPSERIQKMAIDLGFQQTHICQ 237 Query: 235 NADNDALLRALQ 246 A+L+++ Sbjct: 238 PITAQAVLKSIN 249 >UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A578_ALHEH Length = 261 Score = 217 bits (553), Expect = 3e-55, Method: Composition-based stats. Identities = 72/245 (29%), Positives = 113/245 (46%), Gaps = 2/245 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ L L G W P +E P + A +AALGE+D L +S + Sbjct: 9 VLVTRPAHQAAGLCRTLEAAGARVWALPTLEIVPQPESALPAAAVAALGEADWLIFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV + + + + A+G+ T ALH V PQ SE L + P Sbjct: 69 AVHHGLACMARHGVRPRPDARIAAVGKGTERALHRVGLSVTAVPQAGFTSEDLAREPAFG 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R +I+RG+ GR + + L +GAEV F Y+ D QA + V Sbjct: 129 DMRGQRVMIVRGDSGRAWLAEHLRGQGAEVAFLAVYRAVRPQVDAQPVVEALQAGRLHSV 188 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD-IKVADNADNDAL 241 ++TS L LW ++ R + L+ VS R+A+ A + G + VA + ++ L Sbjct: 189 IITSVRGLDNLWFMLGDSGRV-LVQRRALVTVSPRIARYAEQAGHTGPVVVARSPADEDL 247 Query: 242 LRALQ 246 L+A+ Sbjct: 248 LQAVH 252 >UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSU1_9GAMM Length = 243 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 81/245 (33%), Positives = 122/245 (49%), Gaps = 8/245 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILV RP ++ + L G H P++ P + + + + D +S Sbjct: 4 RILVIRPLRQADQFIELLERAGNQVCHIPVMAIEPVVDGQSIKNLILEVDNFDKAICVSG 63 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A A L + P +YFAIG+ TA L L P R+ SE LL LPEL Sbjct: 64 NAAELAIEWLDRYWPMQPVGIEYFAIGQQTAHILGAADI-VALSPSGRQNSEALLALPEL 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q+++ +R ++ RG GGRE++GDTL RGA V +CE Y+R R Q E Sbjct: 123 QDLSDQRVIVFRGRGGREILGDTLIERGARVDYCELYERVINPQKA--LLARKQMLESDC 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +V SGE+L L + E ++V SER+A++A +LG+++I A+NA +A+ Sbjct: 181 LVAHSGELLTALGDQSGESGAE-----TAVVVPSERVAEIAWKLGYRNIVSAENALPEAM 235 Query: 242 LRALQ 246 L A+Q Sbjct: 236 LAAVQ 240 >UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassified Gammaproteobacteria RepID=A4A9F8_9GAMM Length = 261 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 72/235 (30%), Positives = 117/235 (49%), Gaps = 3/235 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLP-QLADQLAALGESDLLFALS 60 +LVTRP+ + L+ L G V H P+++ P LP +L L + +S Sbjct: 6 RVLVTRPAGQADSLIGALSDAGFVPLHLPMLQIEPLDPLPGAQRQRLMDLDRYAHVIFVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +A ++ + P+ Y+A+G++TAL L + P+ SE LL +P Sbjct: 66 ANAARLGVERIRDYWPQLPQGQLYWAVGKSTALCLEAEG-LDVRRPERDMSSEGLLAMPG 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + +R LI++G GGR+ + L RGAEV CY+R +D ++ Sbjct: 125 LAELQSQRVLIVKGEGGRKFLEVKLRERGAEVDSLACYRRDYAAHDRQACRDLLGDHDLA 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +++V+SGE L++L SL+ Q L LLV S+R+A+ A LGW ++ A+N Sbjct: 185 LILVSSGEGLERLTSLL-QPEEHTNLAMTTLLVPSQRVAEQALGLGWTHVECAEN 238 >UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus RepID=HEM4_PROMI Length = 199 Score = 215 bits (549), Expect = 8e-55, Method: Composition-based stats. Identities = 94/195 (48%), Positives = 121/195 (62%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE+L RL G+ A+H PLIE + G++L L ++L L D LF LS Sbjct: 1 MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV +A QL+Q + WP Y+ IG++TA ++ I YP+ E SE LL L Sbjct: 61 KNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I KR L+LRGNGGREL+ TL RGA V CECYQR I Y E A++W+ +V Sbjct: 121 LQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVE 180 Query: 181 MVVVTSGEMLQQLWS 195 + EMLQQL S Sbjct: 181 YLCGHQCEMLQQLLS 195 >UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=7 Tax=cellular organisms RepID=A0LN72_SYNFM Length = 519 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 57/246 (23%), Positives = 91/246 (36%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR + L LG FP I P +L + + L D S Sbjct: 255 RIVVTRAREQASDFKGMLTELGAHCIEFPTIAIEPPPSWRELDEAIRRLASYDWAIFTSV 314 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V F +L L AIG TA AL + L P + +E +L Sbjct: 315 NGVRFFMERLRALGLDVRELKGVRLAAIGPKTAEALEKTGLRVDLVPSEYR-AESILDSL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ +R LI R R+++ +TL A+GA V Y+ G E A R++ E+ Sbjct: 374 GDADLRERRFLIPRAMVARDILPETLRAKGALVEVVPAYRTVIPRERGPEIAERFRKAEI 433 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS + +SL + L + + A+ A + G + + Sbjct: 434 HCLTFTSSSTVSNFFSLFDRGEILPLLEGVAIACIGPVTAQTAVKHGLKVHIMPAEYTIP 493 Query: 240 ALLRAL 245 L A+ Sbjct: 494 GLANAI 499 >UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uroporphyrinogen-III synthase n=27 Tax=cellular organisms RepID=B2A1G8_NATTJ Length = 516 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 96/250 (38%), Gaps = 7/250 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL ++ LG FP I+ L + + L E + L S Sbjct: 255 NILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSV 314 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V ++L D +L AIG T +L + + PQ+ +E L+ L Sbjct: 315 NGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQE-YRAEALIDLM 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + Q +G R LI R RE++ + L +G +V Y+ D + + E+ Sbjct: 374 KEQVKSGDRVLIPRAKEAREVLPEALREQGLKVDVITAYETVKDTKDTEKVRKMLKQNEL 433 Query: 180 TMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + TS ++ ++ L + + + A ++ G + +A+ Sbjct: 434 DAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTCQQYGIEVNSIANE 493 Query: 236 ADNDALLRAL 245 L+ +L Sbjct: 494 YTIPGLVESL 503 >UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillaceae RepID=C5D5K6_GEOSW Length = 266 Score = 210 bits (534), Expect = 4e-53, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 96/245 (39%), Gaps = 5/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR + +LR G PLI SP ++ + L D L S Sbjct: 9 TVLVTRGKEQAKAFSEKLRKAGATPIEIPLISISPSSHREEIERCVRQLPNYDWLIFTSA 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F + ++ LP +G+ TA AL T P + ++E +++ + Sbjct: 69 NGVRFFFPFVKKET----PLPKVAVVGKKTAAALKTYGVSPAAIPSE-FVAEGMIEALKP 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 R L+++GN R ++ D L GA++T Y+ + + R++ + Sbjct: 124 LVKPRDRVLLVKGNLARPVLRDALINMGADITDLIVYETLMNESGKEQLLYLLRERKLDV 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS +Q ++ + L C + + + A + G D D + Sbjct: 184 ITFTSSSTVQSFIRMMEEEDIASLLSGCVIACIGPITKETAEKAGLAVHICPDEYTIDDM 243 Query: 242 LRALQ 246 ++ ++ Sbjct: 244 IKEME 248 Score = 47.5 bits (112), Expect = 4e-04, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 41/123 (33%), Gaps = 5/123 (4%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 ++GK L+ RG + + L GA + E Q ++ Sbjct: 5 LSGKTVLVTRGKEQAKAFSEKLRKAGATPIEIPLISISPSSHREEIERCVRQLPNYDWLI 64 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 TS ++ + + + ++ VV ++ A + G + + ++ Sbjct: 65 FTSANGVRFFFPFVKKETPLP-----KVAVVGKKTAAALKTYGVSPAAIPSEFVAEGMIE 119 Query: 244 ALQ 246 AL+ Sbjct: 120 ALK 122 >UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burkholderia RepID=Q143B4_BURXL Length = 672 Score = 209 bits (533), Expect = 6e-53, Method: Composition-based stats. Identities = 71/265 (26%), Positives = 111/265 (41%), Gaps = 24/265 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++TRP+ EL++RL G FPLI+ +P L L++L L+ +S Sbjct: 18 FTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVS 77 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQ----KILYPQD-------R 109 +AV +A + D WP +G + AL ++ P R Sbjct: 78 PNAVDYA---FARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETAR 134 Query: 110 EISEVLLQLPELQ----NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY 165 SE L + N+ GKR LI+RG+GGRE + + L GAEV Y+R Sbjct: 135 FDSEGLFAAIDTALGATNLEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEP 194 Query: 166 DGAEEAM--RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAK 220 A A ++TS E ++ L L L L+ R+A+ Sbjct: 195 SIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQLKRAALVTPHPRIAQ 254 Query: 221 LARELGWQDIKVADNADNDALLRAL 245 AR LG+ I V+ A ++ ++R L Sbjct: 255 TARALGFDSITVS-GAGDERIVRTL 278 >UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella burnetii RepID=A9KDC7_COXBN Length = 268 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 71/264 (26%), Positives = 108/264 (40%), Gaps = 29/264 (10%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP----------------GQQLPQLAD 45 +I++TRP GE L + G FP + P ++ D Sbjct: 10 TIMITRPEGQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDD 69 Query: 46 QLAA---LGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK 102 ++ L SD+L LS +AV + + ++K AIG TA AL Sbjct: 70 KMTKAGFLNSSDILIFLSANAVKHSPILNFKAEQKL------VAIGTGTAAALFQRGLSV 123 Query: 103 ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA 162 P + SE LL LP L + GK I G R + + L RGA V Y+R Sbjct: 124 DAVP-EHFSSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYRRER 182 Query: 163 IHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 + + + +V TS E LQ L +L +HWL L+V+S+R+ LA Sbjct: 183 PVVNKKT-IDALTHQTLHAIVSTSAESLQNLCTLFES--HQHWLHRIPLVVISKRMENLA 239 Query: 223 RELGWQDIKVADNADNDALLRALQ 246 + G+ + +ADN A+++ L Sbjct: 240 KSQGFHLVLLADNPGEKAIIKVLS 263 >UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BLH7_TERTT Length = 266 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 79/249 (31%), Positives = 112/249 (44%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLP---QLADQLAALGESDLLFA 58 IL +RP S+L+ G PL+ + Q+ + + + D + Sbjct: 8 RILASRPLAQNSSWSSKLQAAGYRVLALPLLAIAQVQEPAQQQSIKNCILDFDHYDAVIF 67 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQ--KILYPQDREISEVLL 116 +SQ+AV L Q + P+ Y+A+G TA + G + +E LL Sbjct: 68 VSQNAVEATWQWLDQYWPQLPQGITYYAVGIKTAAQVQHFLGSEATVHAALTAMNTEELL 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LP LQ +A +R LI RG GGR +GD L RGA VT+CE YQR + Sbjct: 128 ALPGLQQVAHQRILICRGLGGRPRLGDELENRGAAVTYCELYQRTLPAEAVTQFTDANLN 187 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 ++ V SGE LQ L L L L+V ER+A LA E G+Q I++A NA Sbjct: 188 PAQDVLCVFSGETLQNL--LYVATTAGADLSAFALVVPGERVAALAAEQGFQQIQIARNA 245 Query: 237 DNDALLRAL 245 A+L A+ Sbjct: 246 GEAAMLAAI 254 >UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromonas RepID=A1T0Q9_PSYIN Length = 244 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 82/241 (34%), Positives = 122/241 (50%), Gaps = 6/241 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR +P + LV+ L G VA+ PL+ + + LA D + A+S Sbjct: 5 RLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAK--NYDYIIAVSP 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + Q L WP+ +Y A+G T L + Q ++ P+ SE LL LP L Sbjct: 63 NAVDYTQKALA--GINWPQ-TEYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLL 119 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 N+ GK LILRG GGREL+ DTL RGA V + + YQR AI G WQ + + Sbjct: 120 LNLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNING 179 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +++S E+L++L S++P WL + SER+ A+ GW + KV + + Sbjct: 180 AIISSIELLERLMSVVP-LAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQV 238 Query: 242 L 242 + Sbjct: 239 I 239 >UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT3_THET1 Length = 266 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 103/247 (41%), Gaps = 7/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++TRP+ LV L + G V P IE +P +L +L ALG D + S Sbjct: 18 KIVITRPNHQANSLVKLLESSGAVPILLPTIEINPNVASSELDAELNALGSYDWVVFTSV 77 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L Q + L + IG +T AL + + + P D I+E LLQ Sbjct: 78 NGVKIFFDRLRQLGLEEVPLSRLKFACIGPSTKSALESYGIRVDVMP-DSYIAEALLQAL 136 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++++G+R L+ R + R ++ L A GA V Y+ + YD Sbjct: 137 LDRDVSGQRILLARADSARPVLRKGLEAAGAIVREVPIYRTIPVKYDREYLKDLLAQS-- 194 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS ++ + + + + A A+ELG + VA+ + Sbjct: 195 NAITFTSSSTVKHFLDSLGD--PSYLPQSLCVACIGPITADTAKELGLRVDVVANVYTVE 252 Query: 240 ALLRALQ 246 L++A++ Sbjct: 253 GLVKAIE 259 Score = 43.7 bits (102), Expect = 0.006, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 41/123 (33%), Gaps = 1/123 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + GK+ +I R N + L + GA + +A VV Sbjct: 14 LIGKKIVITRPNHQANSLVKLLESSGAVPILLPTIEINPNVASSELDAELNALGSYDWVV 73 Query: 184 VTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 TS ++ + + Q E L + + G + + D+ +ALL Sbjct: 74 FTSVNGVKIFFDRLRQLGLEEVPLSRLKFACIGPSTKSALESYGIRVDVMPDSYIAEALL 133 Query: 243 RAL 245 +AL Sbjct: 134 QAL 136 >UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marinobacter RepID=A1TXW8_MARAV Length = 270 Score = 206 bits (524), Expect = 6e-52, Method: Composition-based stats. Identities = 66/241 (27%), Positives = 107/241 (44%), Gaps = 3/241 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ RP P L R G A P++ P + P+ L L + A+S Sbjct: 18 RVLICRPEPEASRLAEAFRKAGADARVMPMMAREPLPETPEQRGILQQLDNFSHIIAVSP 77 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A ++ + P ++ +G TA + P + SE LL LP L Sbjct: 78 YAARRLMEEIDHWWPQLPAGLQWYGVGAGTAAVFREHGLKP-RMPAEGWTSEALLALPSL 136 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G++ L+ RG GRELI +TL RGA +T Y+R +Y + + Sbjct: 137 QRVDGEKVLLARGEHGRELIRETLAQRGARITTLPLYRRVLPYYSAKQVKALVADFHPEV 196 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V+ SGE L L L ++ L ++V +ER+A+ AR LG++ V + ++D L Sbjct: 197 VIALSGETLNNLVELGHRYQLA--LTPDIIVVPAERVAEQARALGFRKPLVPGSLNDDDL 254 Query: 242 L 242 + Sbjct: 255 V 255 >UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WVU0_HALHL Length = 264 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 71/220 (32%), Positives = 105/220 (47%), Gaps = 2/220 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP+ E LV L G W FP ++ + + +D L +SQ+ Sbjct: 10 VIVTRPTHQAEGLVHALEAAGAGVWRFPTLDIIAEPEDAARQEAARRAACADWLIFVSQN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AVA ++ +G+ TA AL +++LYP+ SE LL +L Sbjct: 70 AVAHGLPRIRAAGGP-AGHARCATVGQGTAEALRRNGIEEVLYPRHGATSEDLLAETDLG 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 I+ R +I+RG GGR + + L ARGAEV F E Y+R D A +A V +V Sbjct: 129 RISAGRVMIVRGVGGRPYLAEALRARGAEVDFLEVYRRVRPSTDPAPLLEAAEADRVQVV 188 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 V TSGE+L L+ R WL ++V+ ER+A +A Sbjct: 189 VATSGEVLDNFLELVGDRGR-RWLARAGVVVIGERVATMA 227 >UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomonadaceae RepID=HEM4_PSEAE Length = 251 Score = 203 bits (516), Expect = 5e-51, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 113/235 (48%), Gaps = 11/235 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+TRP L + L G + PL+ P ++ P+ + L + +S+ Sbjct: 5 RLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSK 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 A +L DR WP+ P + ++G TA L + YP+ + SE LL LP Sbjct: 65 PAARLGLERL---DRYWPQPPQQTWCSVGAATAAILEAYG-LDVTYPEQGDDSEALLALP 120 Query: 120 ELQN---IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 Q+ + + LI+RG GGRE + + L +G +V + Y+R A Y E R +A Sbjct: 121 AFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRA 180 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + +VV+SG+ LQ L+ L + E + L V S R+A++ARELG Q + Sbjct: 181 ERLNGLVVSSGQGLQNLYQLAAADWPE--IGRLPLFVPSPRVAEMARELGAQRVI 233 >UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=23 Tax=cellular organisms RepID=Q2RJ27_MOOTA Length = 520 Score = 200 bits (510), Expect = 2e-50, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 5/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP E L L LG +FP+I P L L A+GE D + S Sbjct: 258 RVIVTRPRAQAEGLTRSLADLGAEVINFPVIRTEPPADWHPLDTALDAIGEFDWIIFTSA 317 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + +L ++ + L AIG T+ AL P++ ++E + Sbjct: 318 NGVRYFWRRLLERHQDIRSLAGIRIAAIGPATSRALKERGLLTDWQPRE-YVAEAV-ASG 375 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G+R L+ R + R + L +GAEVT Y+ + A +V Sbjct: 376 LGPRVRGRRVLLPRADIARPFLAVDLRRQGAEVTEVTAYRTVKNEENAGSLKEMLAAGKV 435 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V TS ++ L+ + + + + A ARE G Q A + Sbjct: 436 AAVTFTSSSTVRAFLDLLGDGALD-LVQGIDVFCLGPVTAATAREAGLQVAATAGEYTEE 494 Query: 240 ALLRALQ 246 L+RA++ Sbjct: 495 GLVRAME 501 Score = 45.2 bits (106), Expect = 0.002, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 44/131 (33%), Gaps = 1/131 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + + G+R ++ R E + +L GAEV + + Sbjct: 246 LAWLEDKPLFGRRVIVTRPRAQAEGLTRSLADLGAEVINFPVIRTEPPADWHPLDTALDA 305 Query: 176 AREVTMVVVTSGEMLQQLW-SLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 E ++ TS ++ W L+ + L R+ + ++ +E G Sbjct: 306 IGEFDWIIFTSANGVRYFWRRLLERHQDIRSLAGIRIAAIGPATSRALKERGLLTDWQPR 365 Query: 235 NADNDALLRAL 245 +A+ L Sbjct: 366 EYVAEAVASGL 376 >UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=2 Tax=Alteromonadales RepID=Q3IF71_PSEHT Length = 616 Score = 200 bits (508), Expect = 4e-50, Method: Composition-based stats. Identities = 67/248 (27%), Positives = 116/248 (46%), Gaps = 11/248 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++IL+TRP G L +L G A FP+++ L + +L+ L +D + +S Sbjct: 2 LNILITRPQGKGAALAQQLEQAGYQASLFPVLKIE---YLTPDSIELSPLTNADKIIFVS 58 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Q AV L + ++ +G+ TA ++ V G + P+ SE LL L Sbjct: 59 QDAV----LALSELKPDINIKAQFYGVGQQTADTIYEVFGVRAAVPKQH-DSEGLLALKS 113 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L ++ ++++G GGR I TL RGA + C YQR I + WQ++ V Sbjct: 114 LADVDSCNIVLVKGIGGRPDIAKTLKQRGAFLNNCVVYQRTPIDPEPNNWIDHWQSQNVH 173 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAR--ELGWQDIKVADNADN 238 +V+TS + ++ + R+ WL CR V SER+ + ++ +I +A A + Sbjct: 174 GIVITSNAAVDAIFKNLAAPQRQ-WLQQCRFYVASERIGAYLQQHQVSSANIHIAAGASD 232 Query: 239 DALLRALQ 246 +A+ + Sbjct: 233 NAMFTCIN 240 >UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralstonia eutropha JMP134 RepID=Q474V0_RALEJ Length = 689 Score = 199 bits (507), Expect = 7e-50, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 111/277 (40%), Gaps = 39/277 (14%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L + L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQAAGLDVLGFPLLSIGPAADDAPLRAALARLDQFALVIFVSP 64 Query: 62 HAVAFAQSQLHQ----QDRKWPRLPDYFAIGRTTALALHTVSGQK----ILYP------- 106 +A+ +A L +WP +G + +AL ++ P Sbjct: 65 NAIQYAVDALAVVQGIAAAQWPPGVPVAVVGPASVMALAERGIVAPDYRVIAPAGADGNG 124 Query: 107 --------QDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECY 158 + R SE L E + G+ LI+RGNGGR+ +GD L GA+VT E Y Sbjct: 125 TNGGANCEEARFDSEALWAQLEPAALQGRSVLIVRGNGGRDWLGDRLREAGADVTAVEAY 184 Query: 159 QRCAIHYDGAEEAMRWQA--------REVTMVVVTSGEMLQQLWSLIPQWYREHW---LL 207 QR AM+WQA ++TS E ++ L +L L Sbjct: 185 QRTLP----EPTAMQWQAVRDGLSPGAAPQAWLLTSSEAVRNLETLARHNLSPQELATLK 240 Query: 208 HCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 + + R+A+ A+ LG+ I A + LL A Sbjct: 241 QVQCIAPHARIAEQAQALGFTRILRAA-PGDAGLLAA 276 >UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsiella grylli RepID=A8PKZ2_9COXI Length = 262 Score = 199 bits (507), Expect = 7e-50, Method: Composition-based stats. Identities = 69/246 (28%), Positives = 117/246 (47%), Gaps = 5/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP EL ++++ G HFP +E + + ++ +L L + +S Sbjct: 7 LRVLITRPLHQTSELTTQIQNCGGFVVHFPTLEINQVPNIKKINSELKKLNHYHFVIFIS 66 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++V +H WP A G T AL +P+ ++ L Sbjct: 67 PNSVFNTAPSIHAIWPHWPCSTKTIATGLGTVSALKQHHLPSHFHPEKNYTGMGIINLSI 126 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I GK+ LI++G GGR + L RGA V Y+R E+ ++ Sbjct: 127 LQTIKGKKILIIKGQGGRLNLIKNLKTRGASVNNLVVYKRQLPAI---EKQCIPNQEDID 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI-KVADNADND 239 +++ TSG L+ L +L+ + H L ++LV+S RLA +A++LG+ + +ADNA +D Sbjct: 184 VIICTSGTGLKNLVTLLHPRWESH-LFKKQMLVISPRLAVIAKKLGFVKLPLIADNASHD 242 Query: 240 ALLRAL 245 A+L L Sbjct: 243 AILHTL 248 >UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SQ71_HAHCH Length = 260 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 71/250 (28%), Positives = 111/250 (44%), Gaps = 8/250 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP + L + L P I P + + D + L + +S Sbjct: 12 LRVLLTRPQGENDSLRALLEQNSAEVRVLPAIAIEPLPETQAIKDCILDLDRYTHVICVS 71 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +HA + + P+ +FAIG ++A L + + P+ SE LL+ P Sbjct: 72 KHASRLLLELIDAYWPQAPQGVRWFAIGESSAAPLRSYG-LTVNTPEQGCASEQLLEHPG 130 Query: 121 LQ----NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LQ + R LI++G GGREL+ +T+ RGA V E Y+R + YD E + Sbjct: 131 LQARNEDEPPMRVLIVKGCGGRELLTETMQERGAHVATLELYERKTLEYDPNELNEALKQ 190 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +VV SGE L L L Q W ++ S R+A LA+E + K+A Sbjct: 191 WRPEVVVTLSGETLLHLCQL-GQNIGYAW-GDTLFVIPSARVATLAQE-NRLNYKIAPEL 247 Query: 237 DNDALLRALQ 246 ++ALL L+ Sbjct: 248 SDEALLALLK 257 >UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfur-oxidizing symbionts RepID=A1AXB3_RUTMC Length = 248 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 105/247 (42%), Gaps = 14/247 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++L+TRP EEL S + G FP ++ + D D++ +S Sbjct: 1 MNVLLTRPLLQVEELQSMVTKSGNKPLLFPTLKLNSI-------DAKVENNYYDVIIFIS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L FA+G TA L + +P+ + SE LL L Sbjct: 54 VNAVEYGLKILKTI-----SYHKIFAVGSATARKLSENDIEIDDFPRKKASSEALLALDS 108 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMRWQARE 178 + + K LI RG GRE++ L + +V + E Y+R + + + +R Sbjct: 109 VAQLYHKTILIFRGQSGREVLKQGLIKQNNQVEYVEVYERVNHNINSLHRQSLDELLSRN 168 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ +TS + ++ L + Q L + L+V+S+R+ +G+ + V N N Sbjct: 169 EGVISITSIDSMKLLVKISSQILDVDRLKNYLLVVLSDRIKTYVNSIGFNKVLVTPNTSN 228 Query: 239 DALLRAL 245 + ++ L Sbjct: 229 NGIISVL 235 >UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III C-methyltransferase n=6 Tax=Ralstonia RepID=A3RYV4_RALSO Length = 1065 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 65/249 (26%), Positives = 103/249 (41%), Gaps = 14/249 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP LV+ L G FPL++ +P L L LA L+ +S + Sbjct: 394 VVVTRPRAQALMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 453 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK---------ILYPQDREISE 113 AV A + + + +WP+ +G +A AL + + R+ SE Sbjct: 454 AVQQAFAAM-PEGFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSE 512 Query: 114 VLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE-AM 172 L + ++G+ LI+RGNGGRE + D L G V E Y+R D A A+ Sbjct: 513 ALYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAAL 572 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQD 229 R +TS E ++ L SL L R+ + A+ LG++D Sbjct: 573 REVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRD 632 Query: 230 IKVADNADN 238 + + D+ Sbjct: 633 VTLTGAGDD 641 >UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=1 Tax=Pseudoalteromonas tunicata D2 RepID=A4CFD4_9GAMM Length = 614 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 80/246 (32%), Positives = 121/246 (49%), Gaps = 11/246 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTRP G ELV++L+ LG A FPL+ P L + LA LGE+D L +SQ Sbjct: 4 ILVTRPDTKGAELVAQLKKLGHHAISFPLLALEP---LAVSSAALAPLGEADKLIFISQD 60 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV L+ P +FA+G TA + + G K + SE LL L ELQ Sbjct: 61 AVK----ALYALKPNLKHQPQFFAVGEKTAAVIAELFGVKARI-AKPQDSEGLLALKELQ 115 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 +I + ++L+G GR LI L RGA V Y+R + + +WQ +++ + Sbjct: 116 HIEQQNIVLLKGQDGRPLIAQKLKQRGAFVHAVVLYRRQPVKGVASGWIKQWQQQKIDSI 175 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW--QDIKVADNADNDA 240 V+TS + ++ + + WL CR V SER+A + +I++ A ++A Sbjct: 176 VLTSNAAVDAIFRELAE-NEVKWLKTCRFYVASERIANYLSQFAIAANNIQICAGASDEA 234 Query: 241 LLRALQ 246 +L A+ Sbjct: 235 ILTAIS 240 >UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina loihiensis RepID=Q5QUS2_IDILO Length = 251 Score = 197 bits (501), Expect = 3e-49, Method: Composition-based stats. Identities = 75/246 (30%), Positives = 117/246 (47%), Gaps = 14/246 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDL--LFALS 60 +L+ RP + ++ +LR G+ + IE P LP +QL + + + +S Sbjct: 9 VLLLRPGKSPDDFTQQLRKTGRECFVHSFIEIEP---LPVNKEQLTQIKQKHWDGIVIVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 ++A +A + +P Y+A+G TA + P SE LL+L Sbjct: 66 KNAAHYASRA------GFSGVPSKYYAVGPGTASFACKHLNTAVSCPAFIHQSEGLLELS 119 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ELQ + + LI+RG GGREL+ D + ARGA V + E Y+R + + E +W + V Sbjct: 120 ELQKLQQQNWLIIRGEGGRELLADAIRARGASVDYWEVYRRKQLTLNDPELIQQWIS-SV 178 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +VVTS E L S +P + WL C+ +V S RL L +IKV +A + Sbjct: 179 GTIVVTSAEQLGYFLSSMPNS-AQSWLDSCQWIVPSHRLKGLIPFGQSDNIKVTGSAADA 237 Query: 240 ALLRAL 245 L+ AL Sbjct: 238 ILMNAL 243 >UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KSU6_9GAMM Length = 679 Score = 196 bits (500), Expect = 4e-49, Method: Composition-based stats. Identities = 82/245 (33%), Positives = 131/245 (53%), Gaps = 7/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TRP L + L G + P++ P P D L AL ++DL +S Sbjct: 4 TVILTRPQEDSARLAAILAERGWDVFVQPMLRMEPLA--PAAIDALPALTDNDLAIFISA 61 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV L ++ R + A+GR TA L +G ++ P DRE SE LL LP L Sbjct: 62 NAVRQGLPHLAERLRDAGMVS--LAVGRRTAQEL-EAAGLPVMTP-DREDSEGLLALPAL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + I+G R L+++G GGR ++ +TL RGAEV CYQR D + A R + Sbjct: 118 REISGHRVLLVKGEGGRAVLAETLRTRGAEVIEFVCYQRVNESLDATDFAGELAKRRPLV 177 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + +S + L+++ L+ + + + L+ ++V SER+A++A ELGWQ + A NA ++A Sbjct: 178 IQASSEQTLRRVTELLAEGGQPN-LVAENVVVPSERVAQVAAELGWQHVITAPNAGDEAF 236 Query: 242 LRALQ 246 LR L+ Sbjct: 237 LRVLE 241 >UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacillus denitrificans ATCC 25259 RepID=Q3SFT6_THIDA Length = 252 Score = 196 bits (498), Expect = 8e-49, Method: Composition-based stats. Identities = 83/244 (34%), Positives = 117/244 (47%), Gaps = 8/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR L + +R G A+ FP + F + +L LA + +D + +S Sbjct: 9 TILVTRAPRQAAALSAAIRAAGGSAFEFPALAFEAVP-VDRLQASLAQVVAADFVIFVSP 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A F + + A+G TA AL ++ P D + SE LL LP+L Sbjct: 68 NAAEFGMAAIGSLAAGRS----VLAVGPGTARALAAQGLDAVITP-DGQDSEALLALPQL 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++ GKR +I+RG GGR L+GDTL ARGAEV + ECY+R A D A RWQA + Sbjct: 123 LDVDGKRVVIVRGIGGRALLGDTLAARGAEVHYMECYRRLAPTADAAPLIARWQAGGIDA 182 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V V S E L L +L+ + L H L E++A AR G A + L Sbjct: 183 VTVASAETLHNLAALLGEAGAP-LLAHTPLFAPYEKIAAAARSFGVAQ-ATATPGGDAGL 240 Query: 242 LRAL 245 + L Sbjct: 241 VAGL 244 >UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Saccharophagus degradans 2-40 RepID=Q21EF8_SACD2 Length = 290 Score = 195 bits (497), Expect = 9e-49, Method: Composition-based stats. Identities = 75/271 (27%), Positives = 117/271 (43%), Gaps = 25/271 (9%) Query: 1 MSILVTRPSPAGEELVSRLR----TLGQVAWHFPLIEFSPG---QQLPQLADQLAALGES 53 + I+ +RP E R+ A PL+E P + QL Q L + Sbjct: 8 IRIIASRPVAQNSEWCKRIEMFNSEAVWRALPIPLLEIIPVTGEAEKRQLQTQALGLDDY 67 Query: 54 DLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTV-------SGQKILYP 106 + +SQ+AV + L + P+ + +G T A+ Q +L Sbjct: 68 QKILFVSQNAVEHFFTCLEDYWPQLPKQLCFIGVGEKTKQAILQQLDRWGCAGDQIVLGG 127 Query: 107 QDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD 166 D SE LL +PELQ + ++ LI RG GGR ++G+ L ARGA + +CE YQR Sbjct: 128 VDAMNSEALLAMPELQQVDAEKILICRGVGGRPMLGEILVARGARIEYCELYQRALPKQA 187 Query: 167 GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCR-----------LLVVS 215 A A + V SGE L L +++ + ++V Sbjct: 188 VAVLAEADLNSTTDICPVFSGETLTNLVAVLAKHSNPRASEKPPFRLPAQWRALIVVVPG 247 Query: 216 ERLAKLARELGWQDIKVADNADNDALLRALQ 246 ER+A+ A+ +G++ I VA NA A+L+A+Q Sbjct: 248 ERVAQHAKAVGFKRIAVAKNATEPAMLKAIQ 278 >UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bacteria RepID=D2L438_9DELT Length = 514 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 97/245 (39%), Gaps = 4/245 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTR +LV L G + FP IE +P + + L + D + S + Sbjct: 255 VVVTRSREQASDLVRLLAEEGACCYEFPAIEIAPLADTTPVRQAASRLYDYDWVIFTSVN 314 Query: 63 AVA--FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V FA+ D + AIG TA AL + + P +R ++E +++ Sbjct: 315 GVKCFFAEVDALGLDARAFAGIRIAAIGPATAEALASKGLKADFLP-ERFVAESVVEGLL 373 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 IA +R LI R R+++ + L GA+V+ Y + D E +A E+ Sbjct: 374 ALGIADRRVLIPRAREARDVLPEKLAEAGADVSVLPVYDTRPVDQDPQEILEAIRAGEIR 433 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V TS ++ ++ IP + V+ AK E G +A A Sbjct: 434 YVTFTSSSTVKNFFAKIPPAALQAAGTVKT-AVIGPITAKTLAEYGLSADVMAAAYTVPA 492 Query: 241 LLRAL 245 L A+ Sbjct: 493 LAEAI 497 Score = 52.1 bits (124), Expect = 2e-05, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 33/104 (31%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A + L +L G P+ + P Q PQ + GE + S Sbjct: 381 RVLIPRAREARDVLPEKLAEAGADVSVLPVYDTRPVDQDPQEILEAIRAGEIRYVTFTSS 440 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY 105 V +++ + IG TA L + Sbjct: 441 STVKNFFAKIPPAALQAAGTVKTAVIGPITAKTLAEYGLSADVM 484 >UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivorax RepID=Q0VM29_ALCBS Length = 243 Score = 193 bits (490), Expect = 5e-48, Method: Composition-based stats. Identities = 69/244 (28%), Positives = 104/244 (42%), Gaps = 16/244 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP + L+ L G H P + P + L L +F S Sbjct: 9 RVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASV 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A A S + +WP + A+GR TA L + PQ +E +L LP L Sbjct: 69 NAARLALSAMADLWPQWPVGVHWLAVGRATAAELESWH-LPATVPQQGFNTEAVLALPCL 127 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + K+ LI RG+ GREL+ TL +RGA V Y+R A E Sbjct: 128 QQLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKAASP-------VLIPAETDW 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V++TS + Q + +P C ++ ER+A + R D+ VA +A ++ + Sbjct: 181 VMITSVQGWQAIGGSVPPC--------CGVVAAGERVADVVRAEHSGDVSVAASAHDEDM 232 Query: 242 LRAL 245 L AL Sbjct: 233 LSAL 236 >UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JT00_9GAMM Length = 618 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 67/246 (27%), Positives = 107/246 (43%), Gaps = 9/246 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TR + + L++ + G + ++ P + AAL + +S Sbjct: 8 LRVLITRTAKQAKPLLTLIEAEGGMGTPAGVLSIEADYGDPSVTAAKAALDQYHRFIFVS 67 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L P +GR T L P+ SE LL LP Sbjct: 68 ANAVEHGLAAL----GSLPDEARLACVGRKTRQTLEQAGYSVADCPESDFNSEALLALPS 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN+ G+R LI+RG+GGR+LI DTL RGA+V ECY R D ++ Sbjct: 124 LQNVDGERILIVRGHGGRQLIRDTLQQRGAQVDSVECYHRQLSDGDFRPLQDAIESGAFD 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI-KVADNADND 239 ++ + +L+ Q L L+ VS + ARELG+ I +A +A ++ Sbjct: 184 VIC----PSSSESLALLSQACPSKSLKSLPLIAVSATMQDKARELGFTQIAAMAKDATDE 239 Query: 240 ALLRAL 245 ++ AL Sbjct: 240 SIFDAL 245 >UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia psychrerythraea 34H RepID=Q48AW9_COLP3 Length = 253 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 82/252 (32%), Positives = 121/252 (48%), Gaps = 15/252 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP ++L L G + L ++ D AL +D+L +S Sbjct: 6 LKVLITRPKAKAQQLALLLNQQGILNTSQTLFDYQKN---ASANDIATALENADILIFVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQ-DREISEVLLQ 117 AV FA + P FA+G T AL + IL P +E SE LL+ Sbjct: 63 VAAVEFAHAS-----YPLPNNLSQTIFAVGNATKKALQAIGMTTILSPPPQQEHSEGLLK 117 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LP+L + GKR +I RGNGGRE I ++LT RGAEV + E YQR A +W+A+ Sbjct: 118 LPQLSKVIGKRIIIFRGNGGREHIANSLTLRGAEVRYIESYQRVWRTL-PIIIAEQWRAQ 176 Query: 178 EVTMVVVTSGEMLQQLWSLIPQW---YREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++ +VVTS ++L L + +W C +VVS+R+ K A+ LG + + Sbjct: 177 KINCIVVTSNDILLALLKYLASTTNSTDNYWQSQCLWVVVSDRIEKNAKALGLKRVINTH 236 Query: 235 NADNDALLRALQ 246 A + L LQ Sbjct: 237 GASSQILCNTLQ 248 >UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH Length = 513 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTR ELV L LG P I+ P + L + + L + D + S Sbjct: 258 TIVVTRARVQASELVGSLSALGARCIEIPTIQVVPPRDPAPLVNAVKNLSDFDWVVFTSV 317 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V L+ Q D + + IG T L + P+ V+ Sbjct: 318 NGVKLFFKTLYGEQMDVRALGGLKFACIGPATKAELFVHGIVSDILPKTYMAESVVEAFS 377 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ I GKR L+ R R ++ + L GA VT Y+ A H D AE A +V Sbjct: 378 NVE-IQGKRVLLPRAKQARTILPEELDKLGARVTEVTAYETIAEHLDEAELARLVAESKV 436 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V TS ++ L+ + A+ A LG + VA Sbjct: 437 DIVTFTSSSTVENFKRLVMDKKVLEMGPEVIAACIGPITAETAASLGIRPDIVATEFTIP 496 Query: 240 ALLRAL 245 L+ A+ Sbjct: 497 GLVDAI 502 >UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z3B7_9GAMM Length = 660 Score = 188 bits (479), Expect = 1e-46, Method: Composition-based stats. Identities = 75/246 (30%), Positives = 118/246 (47%), Gaps = 8/246 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ ++TRP E L L G + PLI + +L L D+ +S Sbjct: 3 LTAVLTRPGGVVEPLQLVLEQRGVDTFVQPLINI---ASISVEHRELITLYPGDICIFIS 59 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV S L Q R+ A+GR TA A+ + P SE LL L Sbjct: 60 VNAVEQGLSNLAPQLREL--GCPILAVGRATASAISAAGF-DVSVPSQA-DSEGLLGLDI 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + GK+ +I++G GGR L+ + L RGA+V CY+R D + + RE Sbjct: 116 LHGVKGKQVVIVKGEGGRGLLAEALRERGADVVSYVCYRRDPTGIDAGQFCWQLCEREHV 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + +SGE+++QL L+ Q + + LL ++V S R+AK+A LGW ++ A A +D+ Sbjct: 176 VFQASSGEIVEQLTELLGQGGQPN-LLDSPVIVPSGRVAKIAVGLGWTNVITAAGAGDDS 234 Query: 241 LLRALQ 246 L A++ Sbjct: 235 FLSAIE 240 >UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobacterium violaceum RepID=Q7P209_CHRVO Length = 243 Score = 186 bits (474), Expect = 4e-46, Method: Composition-based stats. Identities = 89/246 (36%), Positives = 121/246 (49%), Gaps = 13/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L RP L+ +LR G A H PL+E P + AA +D LF +S Sbjct: 3 RVLAARPLAQCAGLLEKLRAEGWQAGHLPLMEIEPLPEALAALPAQAA--RADALFWVSP 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ L D RL +G +A L +SG+ +L+P SE LL LPEL Sbjct: 61 SAIDVGWPALAGMDFSGKRL---ACVGAASARRLADLSGRPVLHPTAGSDSEALLALPEL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + +G+R LI+RG GGR L+ DTL ARGAEV E Y+R DGA + + A Sbjct: 118 ADASGQRWLIVRGQGGRPLLADTLAARGAEVGVAEVYRRV----DGAPDWAAFDAAPPDA 173 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLL-VVSERLAKLARELGWQDIKVADNADNDA 240 V++TSGEM++QL+ L R L C L V R+A+ G I V AD+ A Sbjct: 174 VIITSGEMVEQLFRLAGP--RRTGALQCLLYCVPHPRIAERLAAFGAARI-VTTRADDAA 230 Query: 241 LLRALQ 246 L+ L+ Sbjct: 231 LVAGLK 236 >UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02D79_SOLUE Length = 494 Score = 186 bits (474), Expect = 5e-46, Method: Composition-based stats. Identities = 64/244 (26%), Positives = 93/244 (38%), Gaps = 9/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR + L + L +LG P IE P L +A L D L S Sbjct: 247 RIVVTRAREQADALGAALSSLGAGVIELPTIEIGPAADSGPLERAIAELETYDWLIFTSA 306 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F +L + AIG T A+ + + L ++E LL+ Sbjct: 307 NGVRFFVERLDDLRKLRS---KICAIGPATRAAVEALHVKVDLM-GKEYVAEGLLEAFAA 362 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++AGKR L+ R R+L+ L RGA+V E Y+ A GA + AR Sbjct: 363 HDLAGKRVLLPRAAVARDLVPVELAKRGAQVDVVEAYRTAAPAGLGARVREVF-ARRPDC 421 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ L R+ + + ARELG A D L Sbjct: 422 VTFTSSSTVRNFVEAAGAGA----LEGVRVASIGPVTSATARELGVAVTVEARPFTVDGL 477 Query: 242 LRAL 245 + A+ Sbjct: 478 VDAV 481 Score = 40.2 bits (93), Expect = 0.063, Method: Composition-based stats. Identities = 19/121 (15%), Positives = 40/121 (33%), Gaps = 4/121 (3%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 +AGKR ++ R + +G L++ GA V + G E + ++ Sbjct: 243 LAGKRIVVTRAREQADALGAALSSLGAGVIELPTIEIGPAADSGPLERAIAELETYDWLI 302 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 TS ++ + + L ++ + L + + + LL Sbjct: 303 FTSANGVRFFVERLDDLRK----LRSKICAIGPATRAAVEALHVKVDLMGKEYVAEGLLE 358 Query: 244 A 244 A Sbjct: 359 A 359 >UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QSV6_CHRSD Length = 251 Score = 186 bits (472), Expect = 7e-46, Method: Composition-based stats. Identities = 83/248 (33%), Positives = 118/248 (47%), Gaps = 10/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTRP G LV L T G A H L+ P + D++ S Sbjct: 6 RIVVTRPGEGGRRLVDALSTAGFEAVHPALMTLQPLAADEVERGAVLDFDLYDVVVVTSP 65 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQD--REISEVLLQLP 119 A + + + P+ P ++A+G +TA LH G K P SE LL + Sbjct: 66 FAAECLDEWIDRYWPQLPQGPRFYAVGASTAATLHRTLGIKAKVPDPARGTTSEALLAMR 125 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-RE 178 L + G+RALI+ G+GGR+++ + L ARGA V Y+R D E + W A Sbjct: 126 SLTRLDGQRALIVGGSGGRQVMAEALEARGARVAKLALYRRVYTAPD--EVTVDWLASGA 183 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 T ++VTSGE+L+ L S Q L+ L+V S+RLA LA +G+ VA A Sbjct: 184 FTAMIVTSGELLEHLVSWCGQAA-----LNKPLIVSSQRLATLADTMGFASPHVASGATP 238 Query: 239 DALLRALQ 246 DAL+ A+Q Sbjct: 239 DALVTAVQ 246 >UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=2 Tax=Oxalobacteraceae RepID=A4G3V3_HERAR Length = 260 Score = 186 bits (472), Expect = 7e-46, Method: Composition-based stats. Identities = 74/254 (29%), Positives = 111/254 (43%), Gaps = 15/254 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TRP E L R+ LG+ A FPL++ P L L L L+ +S + Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILPLADQASLQQALRDLSGYALIAFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK----ILYPQ--DREISEVLL 116 A WPR +G + LAL I+ P DR SE LL Sbjct: 69 ----AIDAALAARADWPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTDSETLL 124 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ- 175 +L + K+ LI+RG GR L+ + L A GA+VT Y+R A +D + Sbjct: 125 AELDLPALRNKQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDATRRRELKRL 184 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWL---LHCRLLVVSERLAKLARELGWQDIKV 232 +VTS E L+ L ++ Q + R++V R+ + A+ LG+ +I V Sbjct: 185 LHGQNDWIVTSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRIGETAQLLGFSNITV 244 Query: 233 ADNADNDALLRALQ 246 + +D LL ALQ Sbjct: 245 TRS-GDDGLLAALQ 257 >UniRef50_C9KL86 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL86_9FIRM Length = 508 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 93/251 (37%), Gaps = 10/251 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS-PGQQLPQLADQLAALGESDLLFALS 60 ++LVTR +L + L LG P I + P + +A L L S Sbjct: 258 TVLVTRARSQASKLTACLEELGARVIEKPAIAIAVPDDGYAAVDAAIAKLDSYQWLIFTS 317 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V +L + L AIG+TTA L + + PQ+ +E +L+ Sbjct: 318 TNGVERFMQRLFAAGKDVRALGYAKVAAIGQTTAKKLQSYGICADVVPQE-FRAEGILES 376 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD---GAEEAMRWQ 175 + + + L+ R RE++ + L +GAEV YQ A + Sbjct: 377 LKGKLPPHAKILLPRAAVAREILPEKLREQGAEVDVVPVYQTVMAETSEEERAALREELE 436 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + V TS + L L+ L + + A+ AR+ G + VA Sbjct: 437 NGAIDFVTFTSSSTVVNLVKLLGGIEP---LKGVKTACIGPVTAETARKHGIEPTIVASR 493 Query: 236 ADNDALLRALQ 246 + L+ A++ Sbjct: 494 YTIEGLVEAMR 504 >UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D4B Length = 247 Score = 184 bits (467), Expect = 2e-45, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 7/222 (3%) Query: 27 WHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFA 86 FPL E P ++ + L L L +S +AV F ++++ P Sbjct: 29 LPFPLTEILPLKEYEEFDLILQNLSSYHHLIFISTNAVDFFVARMNFYHITLPSSLIISC 88 Query: 87 IGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLT 146 IG +T L + YP++ SE LL+ +I ++ LI+RG GGRE + L Sbjct: 89 IGPSTKKLLQENFNTPVFYPRESFDSEHLLKSDIFSDIKNQKILIIRGIGGRETLRKGLE 148 Query: 147 ARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH-- 204 +G +T+ ECY R + D E +++TS E ++ +H Sbjct: 149 KKGGLITYGECYTRKYLQIDLEEVRKSTYEFNRIFMLITSYESAKKFMQ---HNITDHLG 205 Query: 205 WLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 WL ++V RL + +I + ++ ND++LR L+ Sbjct: 206 WLKSIHVIVNHIRLKNELNI--FSNITITEDLSNDSILRILK 245 >UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase n=1 Tax=cyanobacterium UCYN-A RepID=UPI0001C33642 Length = 504 Score = 183 bits (466), Expect = 3e-45, Method: Composition-based stats. Identities = 50/256 (19%), Positives = 95/256 (37%), Gaps = 15/256 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR + + +L+ G PL+E P +L + + D L S Sbjct: 247 KVIITRSHESSSQFKFQLQEAGADVITLPLLEILPPSSWERLDGAIQEISSFDWLVLTSA 306 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V F +LH + +G+ TA L + P D ++ P Sbjct: 307 NGVKFFMERLHDLGKDIRILNNIKIAVVGKKTADYLKKFYLKPNFIPSDFIADSLVENFP 366 Query: 120 ELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 E +I GK+ L R GGR+++ +GA +T YQ E + + Sbjct: 367 E--DINGKKILFPRVETGGRDILLKEFIKKGASITEVPAYQSICPKNIDNEIWKILKNEQ 424 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHW--------LLHCRLLVVSERLAKLARELGWQDI 230 V ++ TS ++++ + L + + L + L + + +K +L + + Sbjct: 425 VDIITFTSSKIVKHFYHLFKNIFPDSIEEKKILSKLDNVYLACIGPQTSKTCNDL-FGRV 483 Query: 231 KV-ADNADNDALLRAL 245 V A + L L Sbjct: 484 DVEAKEYTLEGLTNQL 499 >UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PF71_CELJU Length = 277 Score = 182 bits (463), Expect = 8e-45, Method: Composition-based stats. Identities = 79/256 (30%), Positives = 117/256 (45%), Gaps = 16/256 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDL---LFAL 59 I++TRP E +L+ G L+E P + + + + DL + Sbjct: 8 IIITRPQAQAEPWAKQLQAQGFATRLLTLLEIMPLKDETRQRAIQNRVMDFDLYQKAIFV 67 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ---DREISEVLL 116 SQ+AV A L + + P +YFA+G TTA L Q SE LL Sbjct: 68 SQNAVHQAMDWLDRYWPQLPIGIEYFAVGATTARELAVHGIPVTDLAQAESGSMTSEALL 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR--- 173 + LQ +AG++ +I RG GGR +GD L ARGA+V +CE Y+RC + Sbjct: 128 EAASLQQVAGEKVIIFRGLGGRGHMGDVLRARGAQVDYCELYERCLPSHAATGLHQLLAD 187 Query: 174 ---WQAREVTMVVVTSGEMLQQLWSLIPQWYREH---WLLHCRLLVVSERLAKLARELGW 227 WQAR+ ++ + SGE LQ L L+ L LLV SER+ A+ G+ Sbjct: 188 ITCWQARQ-QVMALHSGESLQHLLQLLELPLLSPLRGRLQRAWLLVPSERIRDQAQTAGF 246 Query: 228 QDIKVADNADNDALLR 243 +A+NA + A+ + Sbjct: 247 HRCLLAENATDAAMTQ 262 >UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31JG4_THICR Length = 264 Score = 182 bits (462), Expect = 9e-45, Method: Composition-based stats. Identities = 62/255 (24%), Positives = 110/255 (43%), Gaps = 13/255 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ L TRP E L +R G P ++ P L D +F +S Sbjct: 8 LTFLNTRPVEQAEALSQSVREKGHQVLACPTLKICPRS---LPQQAGVTLSTFDKVFFIS 64 Query: 61 QHAVAFA---QSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 Q+AV +Q + + FAIG++T A+ + ++ ++E LLQ Sbjct: 65 QNAVKQFVDMWQSAYQTHPVFAEKTECFAIGQSTYNAMKALDWPVAKVHSNQYVTEALLQ 124 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LQN+ ++ LI++G GGR + + L A GA VT Y+R + A+ + AR Sbjct: 125 SEVLQNLTDQQCLIVKGKGGRPTLAEGLIAAGATVTEWAVYERVPADFCDAQWQVFRSAR 184 Query: 178 EVTMVVVTSGEMLQQLWSLI-----PQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIK 231 +++++S + L ++ + WL ++V S+R+ ++ WQ + Sbjct: 185 HP-VLLISSLDAWYGLEKMLKNSGYGSKNDQAWLFLQDVIVFSDRIKHALQQQEWQGRLF 243 Query: 232 VADNADNDALLRALQ 246 V N +L AL+ Sbjct: 244 VVPQQSNAGILTALE 258 >UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C4214B Length = 262 Score = 181 bits (461), Expect = 1e-44, Method: Composition-based stats. Identities = 50/244 (20%), Positives = 93/244 (38%), Gaps = 3/244 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTR E ++++ G ++ PL+ F P + QL + + E D L S + Sbjct: 11 VLVTRAKDQAEPFINQIEEAGGISHIIPLLLFQPVKS-DQLEKAITYINEFDWLVFTSAN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V F + ++ +G T L + L P DR ++E L Sbjct: 70 GVRFFLEEFKKRHLPSSLKARIAVVGEKTEAVLDEYGLKADLLP-DRYVAEDLAVTLTTH 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE-VTM 181 AG++ L+ RGN GR L+ L G EV+ Y+ + ++ + + + Sbjct: 129 ITAGEKILMPRGNLGRTLLPKELEKAGIEVSDLTIYETVCPPEAKDQFRAFIKSGQAIDV 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS ++ ++ + E ++ + K A E A + L Sbjct: 189 ITFTSSSAVRHFAQVLLELRIEEPFKDAKIACIGPIAEKTATEYHLNVDITASTYTIEGL 248 Query: 242 LRAL 245 + A+ Sbjct: 249 IEAI 252 >UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina baltica OS145 RepID=A3WKE6_9GAMM Length = 241 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 12/242 (4%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 L+ +P + + ++ L I+ P P + + D + +S++A Sbjct: 8 LILQPDDSRQRIIGALSESAIQFTQHSFIDIEPISVKPLVN------PDYDGVIWISKNA 61 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 V FA ++ FA+G TTA G P + SE LL LPE+ N Sbjct: 62 VKFA----ADAGFRFLPQTSMFAVGPTTARLAANTFGISAYCPTYKHDSESLLTLPEMVN 117 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + ++ LI++G GR+L+ DTL ARGA V+ + Y+R + + +W V ++V Sbjct: 118 VDNQKWLIIKGEKGRDLLFDTLRARGATVSSIDVYRRVKRPLNDETQVTQWMN-TVNLIV 176 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 VTS E L S +P+ WL C +V SERL L + I V +A ++ Sbjct: 177 VTSAEQLGYFLSSLPREAG-GWLSRCDWIVPSERLRDLIPFVAADTITVTGSATESKMIE 235 Query: 244 AL 245 A+ Sbjct: 236 AI 237 >UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERASE AND UROPORPHYRINOGEN-III SYNTHASE TRANSMEMBRANE PROTEIN n=3 Tax=Cupriavidus RepID=B3R610_CUPTR Length = 712 Score = 178 bits (452), Expect = 1e-43, Method: Composition-based stats. Identities = 73/277 (26%), Positives = 106/277 (38%), Gaps = 36/277 (12%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQGAGLDVLSFPLLAIGPAADDAPLRAALARLDTFALVVFVSP 64 Query: 62 HAVAFAQSQLHQQD----RKWPRLPDYFAIGRTTALALHTVSGQKILY------------ 105 +A+AFA L +WP +G + AL Y Sbjct: 65 NAIAFALDALAGVQGSAVARWPVPVAVAVVGPASVAALAERGIAAPAYRVIAPAGANANG 124 Query: 106 -------PQD---REISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC 155 P R SE L + +AGK LI+RGNGGR+ +GD L GA+V Sbjct: 125 AGHDDTVPDAEALRFDSEALWAQLDPAALAGKPVLIIRGNGGRDWLGDRLREAGAQVEAV 184 Query: 156 ECYQRCAIHYDGAEEAMRWQAR-----EVTMVVVTSGEMLQQLWSLIPQWYREH---WLL 207 E YQR GA + + ++TS E ++ L L Q L Sbjct: 185 EAYQRTLPEP-GAMQWQAVRDHLRPGAAPHAWLLTSSEAVRNLDVLARQHLSPQEDAALR 243 Query: 208 HCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 + + R+A+ A LG+ I+ A + LL A Sbjct: 244 QVQCIAPHARIAEQALALGFAHIQRAA-PGDAGLLAA 279 >UniRef50_Q7VKW9 Possible uroporphyrinogen III synthase n=1 Tax=Haemophilus ducreyi RepID=Q7VKW9_HAEDU Length = 251 Score = 178 bits (452), Expect = 1e-43, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 112/247 (45%), Gaps = 6/247 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++L+T P+ ++LV + A + P+ G L L ++ L D + LS Sbjct: 1 MNVLITYPASRAQKLVDMCQQHRIFAIYQPIFSVELGADLLDLPSAMSRLNAGDNVIILS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A FA L + +YF + A + + + + YP D E LLQL + Sbjct: 61 KEAFDFAWQTLADTGFAYRADLNYFVADKYLAAYVTAKTTRPVHYP-DTEQCNQLLQLGK 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + K+ LIL R L + L +V + CY I A+ ++ +A + Sbjct: 120 LLQLTDKKVLILCAEEQRGLFQNQLAEA-KQVQYLACYYHKHIEQLTAQLSLAKRAG-ID 177 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ--DIKVADNADN 238 +++ + ++L L+ I WL+ RL+V+S+ +A +A +LGWQ + +A DN Sbjct: 178 TILIENEDVLLTLYEQIAAE-DCQWLVKTRLVVISQHIANIAEKLGWQSDQVIIAGQTDN 236 Query: 239 DALLRAL 245 LL + Sbjct: 237 QTLLNTM 243 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 178 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 66/246 (26%), Positives = 101/246 (41%), Gaps = 6/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ RP+ LV RLR LG A PLI P + L LA L D + S Sbjct: 311 RVLLVRPAGQETFLVERLRALGAEAVIHPLIRILPPEDWGPLDAALADLARFDWVVFTSA 370 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L + R AIG TA AL + + P D+ I+E + Sbjct: 371 NGVRATLERLRLLGGGSELLREKRLAAIGPATARALREYELEPDIVP-DKFIAEAVAAQL 429 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + +AG R L+ R RE++ L GA V Y+ + D A +A +A + Sbjct: 430 IARGVAGARVLVARAAEAREILPRRLEEAGATVVVVPAYRTELLPLDEAIQA-ALEAGTI 488 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + +T+ + L + + R R+ + A ARELG + VAD + Sbjct: 489 DWIFLTASSTARALAAALGDIKRLSD--RIRIAAIGPVTAGTARELGLRVDVVADTYTAE 546 Query: 240 ALLRAL 245 L+ A+ Sbjct: 547 GLIEAV 552 Score = 41.0 bits (95), Expect = 0.035, Method: Composition-based stats. Identities = 24/102 (23%), Positives = 36/102 (35%), Gaps = 1/102 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + G+R L++R G + + L A GAE + G +A VV Sbjct: 307 LRGRRVLLVRPAGQETFLVERLRALGAEAVIHPLIRILPPEDWGPLDAALADLARFDWVV 366 Query: 184 VTSGEMLQQ-LWSLIPQWYREHWLLHCRLLVVSERLAKLARE 224 TS ++ L L L RL + A+ RE Sbjct: 367 FTSANGVRATLERLRLLGGGSELLREKRLAAIGPATARALRE 408 >UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=Nostocaceae RepID=UPI0001C15AC8 Length = 274 Score = 178 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 92/255 (36%), Gaps = 13/255 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL + LG P +E P L + L D L S Sbjct: 14 TILVTRAVGQSSELSHGITNLGARVIELPALEIGPPSSWRSLDQSILELSTFDWLVFTST 73 Query: 62 HAVAFAQSQL-------HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 + V +++ R+ A+G TA +L + P D + Sbjct: 74 NGVESFFARMALQYKNQQALIRRAINRTKIAAVGEKTAQSLKMHQIEPDFIPPDFIADSL 133 Query: 115 LLQLPELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 + PE N+AGK+ L R +GGR+++ LT +GA+V Y+ Sbjct: 134 VNNFPE--NLAGKKILFPRVESGGRDILVKELTQKGAQVVEVPAYESLCPQSIPTTAQQA 191 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQDI 230 V ++ S + ++ L+ + L + + + +K +L + Sbjct: 192 LINHSVDVITFASSKTVKFFCVLLENNLPQKAEQYLNKSAIASIGPQTSKTCIDLLGRVD 251 Query: 231 KVADNADNDALLRAL 245 A D L++A+ Sbjct: 252 ITAQKHTIDGLIKAI 266 Score = 40.2 bits (93), Expect = 0.066, Method: Composition-based stats. Identities = 18/126 (14%), Positives = 44/126 (34%), Gaps = 6/126 (4%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 ++GK L+ R G + +T GA V + + + + +V Sbjct: 10 LSGKTILVTRAVGQSSELSHGITNLGARVIELPALEIGPPSSWRSLDQSILELSTFDWLV 69 Query: 184 VTSGEMLQQLWSLIP------QWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 TS ++ ++ + Q + ++ V E+ A+ + + + + Sbjct: 70 FTSTNGVESFFARMALQYKNQQALIRRAINRTKIAAVGEKTAQSLKMHQIEPDFIPPDFI 129 Query: 238 NDALLR 243 D+L+ Sbjct: 130 ADSLVN 135 >UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15Z16_PSEA6 Length = 240 Score = 178 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 76/244 (31%), Positives = 112/244 (45%), Gaps = 13/244 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFAL 59 M++L+ RP +R T G A LI Q+ L L L +L D + Sbjct: 1 MTVLIFRPEQKCAPSAARFITAGLPAVGVGLISTQASQEALSSLPSALGSLSSGDGIIVT 60 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S L QQ + P FA+G +TA L + P +E LL L Sbjct: 61 S----TVVSQLLAQQRIELPNSATIFAVGSSTAQGLRAQG-YDVTVPLVP-TTEGLLALS 114 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 L+ IAG +IL+G GGRE + LT RGA V + YQR I A + WQA ++ Sbjct: 115 PLKEIAGHTVVILKGQGGREDLAQQLTQRGATVLLADIYQRIKIATPKATQ--EWQAEQI 172 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 ++ TSGE++ + + + WL +VVS R ++A + G + I V+D+A + Sbjct: 173 RCIIATSGEIIDTAF----EHFDAKWLQSLPWIVVSPRTEQIAVKQGIKTIFVSDDASDQ 228 Query: 240 ALLR 243 AL+R Sbjct: 229 ALIR 232 >UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepID=C1D9V4_LARHH Length = 248 Score = 177 bits (450), Expect = 3e-43, Method: Composition-based stats. Identities = 71/243 (29%), Positives = 105/243 (43%), Gaps = 8/243 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TRP AG L + LRT G + +PL+ P + L AAL +D L +S Sbjct: 6 VIITRPHEAGAPLAAALRTAGFAPFEWPLLALEPEPE--ALDRLPAALAGADWLVVVSPS 63 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A L + P A+GR TA L SG+ +LYP SE LL LP+ Sbjct: 64 AARLIAPALAR----LPAGLRLAAVGRATAQVLEQASGRPVLYPATGNDSEALLALPDWG 119 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + G+ +I +G+GGR + + L RGA V Y+R + D A V Sbjct: 120 ALDGRTVVIAKGHGGRPWLAENLARRGARVVPLALYRRRKLTPDPAALQAALAVHPQAAV 179 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 +VTS E+ + L + R+A+ LG +K A +DA++ Sbjct: 180 LVTSTEIAEAWRQAAGDALWPS-LQSIMHIAPHPRIAERLTALGVMRVKTT-GAGDDAVI 237 Query: 243 RAL 245 AL Sbjct: 238 DAL 240 >UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococcus sp. MC-1 RepID=A0L5L4_MAGSM Length = 259 Score = 176 bits (448), Expect = 4e-43, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 88/244 (36%), Gaps = 3/244 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTRP P + + G P++ +P + L +AA+ D + S Sbjct: 10 TILVTRPQPEADATALLILQAGGTPIITPMLNIAPAEDSQPLQQAIAAIHSFDGVLITSA 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A L Q + P FA+G TA L G + P R E L + Sbjct: 70 NAARAYLDALAAQAQPLSGTPPCFAVGPKTAELLRA-GGATVCQPSSRFDGEALAEAINQ 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ L R GRE + D L VT Y+ A+ + + V Sbjct: 129 WQGKGRHFLFPRAAIGRETLIDGLENDDHRVTMVAAYRALPAQQLSAQAHRYLREKRVDA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + S + L+ E L +S A+ LG+ +A A ++L Sbjct: 189 ALFFSSRTATTFFELLISQALEP--AEMVLAALSPVTAERMASLGFAAHVIAPQATAESL 246 Query: 242 LRAL 245 L+AL Sbjct: 247 LQAL 250 >UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=2 Tax=Synechococcus RepID=Q2JNU8_SYNJB Length = 500 Score = 176 bits (448), Expect = 5e-43, Method: Composition-based stats. Identities = 62/249 (24%), Positives = 97/249 (38%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR L+ G P + P L +A LG+ + L S Sbjct: 246 TVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTSA 305 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +LH+Q R L +G TA L L PQ+ ++E LLQ+ Sbjct: 306 NGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQE-FVAEALLQV- 363 Query: 120 ELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + I+G+R L R +GGRE + L RGAEV YQ + +A + Sbjct: 364 WPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEALKAHQ 423 Query: 179 VTMVVVTSGEMLQQLWSLIPQW--YREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 V ++ S + +Q LI Q E W ++ + + A + + A Sbjct: 424 VDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAAQEY 483 Query: 237 DNDALLRAL 245 + L+ AL Sbjct: 484 TLEGLVEAL 492 Score = 46.0 bits (108), Expect = 0.001, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 42/118 (35%), Gaps = 1/118 (0%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTS 186 K L+ R G + L A+GA V +A + + +++TS Sbjct: 245 KTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTS 304 Query: 187 GEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 +Q + L Q L ++ VV + A + + G + +ALL+ Sbjct: 305 ANGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEALLQ 362 >UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Tax=Glaciecola sp. HTCC2999 RepID=UPI0000E105B4 Length = 249 Score = 176 bits (446), Expect = 7e-43, Method: Composition-based stats. Identities = 67/254 (26%), Positives = 113/254 (44%), Gaps = 22/254 (8%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 LV RP + G + L P + + L D + S+ A Sbjct: 3 LVLRPEHKIDSSQHAFEQAGIPSIGLALQTILPRDDIAEQV-HLVNFHHVDNVIFTSKMA 61 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDRE---------ISEV 114 FA + +A+G++T L + Q + + + SE Sbjct: 62 AQFALPFM----PDLSSHTYVYAVGKSTFQTLAQWTHQYPFWCNNHQLMMPLAHQQTSEG 117 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 +L LP L ++ +R +I++G GGRE + DTL+ RGA V+ C Y+R ++ + +A W Sbjct: 118 ILSLPSLSDVTEQRIVIVKGLGGRETLRDTLSERGAVVSECTVYERITLNNPVSTQA--W 175 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW--QDIKV 232 Q ++T + TS E LQ + + P WL + +VVS R+A+ A +LG Q I + Sbjct: 176 QVTDITGITATSNEQLQLAFDIYP----HSWLTELKWVVVSPRIAQYALKLGIPNQQISI 231 Query: 233 ADNADNDALLRALQ 246 + +AD+ AL+ + Sbjct: 232 SQSADDAALIAHIN 245 >UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polynucleobacter necessarius RepID=A4SWL1_POLSQ Length = 274 Score = 175 bits (445), Expect = 9e-43, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 110/265 (41%), Gaps = 24/265 (9%) Query: 2 SILVTRPSPAGEELVSRLRT---LGQVA-------WHFPLIEFSPGQQLPQLADQLAALG 51 +I++TRP+ +L+ L +A PL+ P + L Sbjct: 5 TIVITRPTGQARQLIEVLTKVIEASAIAKRSLPELVSLPLLTIVPKSDEHLADSIASTLQ 64 Query: 52 ESDLLFALSQHAVAFAQSQLHQQDRKWP-RLPDYFAIGRTTALALHTVSGQKILYPQ--- 107 ++DL +S +AV L + + + R+ +G ++ LAL + YP Sbjct: 65 DADLAIFVSPNAVESVMRLLERDWQDFSKRIIPIGVMGGSSRLALKNHGIGQEDYPTSIY 124 Query: 108 -----DREISEVLLQLPEL--QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 +R SE L Q + + K+ +I +G+GGRE + DTL GA V Y R Sbjct: 125 MPSINERWDSEGLWQELQTLDWDWTHKKVVIFKGDGGREWLADTLQKAGATVEAISTYTR 184 Query: 161 CAIHYD-GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLA 219 + D A + + ++ ++TS E ++ L +I + + L L +A Sbjct: 185 VPLDIDNPAWQVIHEMDFSKSLWLLTSSEAVRYLGEVIRDQF-PYGLESASALCPHHNIA 243 Query: 220 KLARELGWQDIKVADNADNDALLRA 244 A +G+ ++ ++ ++AL++ Sbjct: 244 DAAEAIGFGEVFTSE-PGDEALIKT 267 >UniRef50_B3T8I0 Putative tetrapyrrole (Corrin/porphyrin) methylase n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8I0_9ZZZZ Length = 510 Score = 175 bits (444), Expect = 1e-42, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 90/246 (36%), Gaps = 6/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR L + L G P I+ P + +L L + + + S Sbjct: 255 RVLVTRSRSQASRLCTLLEQAGASTVELPTIQIGPLEDFSELDATLKNIADYQWVIFASA 314 Query: 62 HAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + Q + L AIG TTA AL P R +S V+L+ Sbjct: 315 NAVESVFDRFESQGKDARALAGMTVGAIGPTTAQALSRWGITADFVPS-RPVSAVVLKEL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ L+ + GR+ + LT GA+V Y+ + A + V Sbjct: 374 SGRDWKDVSVLLPSADIGRDELEKGLTNLGAKVNRLAAYRNVPVEGVSG-LAKKAFVDGV 432 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V TS ++ L ++ L + + + ARELG Q A + Sbjct: 433 DIVTFTSSSTVRNLVEMLD--GDRAALETSFIACIGPVTSATARELGLQVDLEATEHTVE 490 Query: 240 ALLRAL 245 L+ AL Sbjct: 491 GLVDAL 496 >UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z5H2_9NEIS Length = 245 Score = 175 bits (443), Expect = 1e-42, Method: Composition-based stats. Identities = 77/246 (31%), Positives = 112/246 (45%), Gaps = 15/246 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP L++ L G P+++ P LA +D L +S Sbjct: 7 RILVTRPPAQSARLMALLSDAGAEPLPLPVLDIVP--DERALAALPTLAEAADWLIFVSP 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ A L ++ K +G +A L +SG+ +L+P+D S LL LPEL Sbjct: 65 SAIDAAWPVLARRKLK----ARLACVGAASAAKLAALSGRAVLHPRDGSDSAALLALPEL 120 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G+R LI+RG GGR +G+TL ARGA +T E Y+R D + V Sbjct: 121 QRLTGQRVLIVRGVGGRAELGETLAARGARLTLAEVYRRVDGEPD-----WSLLEQPVDA 175 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLL-VVSERLAKLARELGWQDIKVADNADNDA 240 +V+TS + ++L+ L + L C L V R+A G I V AD+ A Sbjct: 176 LVLTSSDTAERLFRLAGR--SRSLTLQCLLYCVPHPRIAATLAAHGVTRI-VTTQADDAA 232 Query: 241 LLRALQ 246 L+ L Sbjct: 233 LVAGLS 238 >UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7MKX3_CRYCD Length = 579 Score = 174 bits (441), Expect = 3e-42, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 90/261 (34%), Gaps = 16/261 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGE--------S 53 SI+VTR L S L TLG FP I P + L L Sbjct: 309 SIVVTRSREQASVLSSGLSTLGAQVVEFPTIAIKPRSIDAHIRSALMRLASDAAHVRESY 368 Query: 54 DLLFALSQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREI 111 D + S + V + L++ L AIG TA LH + P+ Sbjct: 369 DWVVFTSANGVQCFFAALNELHLDARSLGGVKVAAIGPATAAELHNQGISPDVVPEKFIA 428 Query: 112 SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH--YDGAE 169 V L E G R L+ R R+ + + LT GA+V Y H + Sbjct: 429 ESVAQALVESGVGRGTRVLLPRAAVARDALPNRLTQAGAQVEVLPLYDTVIPHAEVAAQD 488 Query: 170 EAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLV----VSERLAKLAREL 225 A +A EV+ + TS ++ ++ E L+H V + + R+L Sbjct: 489 LATSLRAGEVSAITFTSSSTVRNFKEMLAAVMPESELIHLLETVTCASIGPVTSDTMRDL 548 Query: 226 GWQDIKVADNADNDALLRALQ 246 AD L+ ALQ Sbjct: 549 TIPVSVQADTHTIPGLISALQ 569 >UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KW75_HALNC Length = 256 Score = 173 bits (438), Expect = 7e-42, Method: Composition-based stats. Identities = 66/250 (26%), Positives = 105/250 (42%), Gaps = 16/250 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTL--GQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 ++I +TRP A +EL + +L ++PL+ F+P + + +A + D Sbjct: 7 LTIGLTRPDGANDELAKAISSLLPDATLLNWPLLTFAPIPERQKALSAMARITAGDWAIF 66 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK--ILYPQDREISEVLL 116 +S AV FA D + A+G TT A+ ++ + P + SE LL Sbjct: 67 VSPRAVRFAHDL---HDLTALPGLHWAAVGDTTTAAIQSLFSDPPQVHRPSSTQDSEGLL 123 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 ++ + G + RG GRE + DTL G V Y+R A+ Sbjct: 124 ASLPIEAMRGHTVWLFRGQTGRETLADTLRQNGITVIPVPVYRRNCTRRPAHLSAL---- 179 Query: 177 REVTMVVVTSGEM---LQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V+T+ E L+QL + LLHC L+V++ R AR LG+ V Sbjct: 180 --PSTWVITAPESLRCLRQLADTLESAEDRARLLHCNLVVINARTEARARSLGFTGAIVR 237 Query: 234 DNADNDALLR 243 A +DA L Sbjct: 238 AEAPDDAALA 247 >UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7R6S2_KANKD Length = 250 Score = 173 bits (438), Expect = 7e-42, Method: Composition-based stats. Identities = 67/246 (27%), Positives = 107/246 (43%), Gaps = 11/246 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRPSP GE L L G A H PLI F+ QL L + L +S+ Sbjct: 6 TIIVTRPSPMGESLCQELNDEGYRAIHCPLIRFTSNTDYSP-EQQLTLLKQHKLWIFVSK 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP-E 120 AV +A L Q+ A+G+ T AL L P+ SE +L L + Sbjct: 65 QAVDYALKDLSQEQLDQFLGHTLIAVGKATQKALQPYG-LSALVPKTP-DSEGILALINQ 122 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 A L++RG+ GR L+ L ++ Y R + + A + Sbjct: 123 FSLPADYPILLIRGDKGRGLLEQELGGP-YQLGVLPVYHRIELTAALPPAMQQASAEKPI 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVV--SERLAKLARELGWQDIKVADNADN 238 VVTSG++L L + + +++++ S R++ LAR++G+ + A +A N Sbjct: 182 GWVVTSGQIL----ELTDKMLSTAGITPEQVVIISGSSRISDLARQMGYTNCYTAKDASN 237 Query: 239 DALLRA 244 ++ A Sbjct: 238 AEIISA 243 >UniRef50_C6D877 Uroporphyrin-III C-methyltransferase n=95 Tax=Firmicutes RepID=C6D877_PAESJ Length = 520 Score = 171 bits (435), Expect = 1e-41, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 94/252 (37%), Gaps = 9/252 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ---LADQLAALGESDLLFA 58 +LVTR +L R+ LG P+IE + + LA + + Sbjct: 256 RVLVTRARAQASDLADRIEELGGEPCELPVIETREPRDEAAVEGIRTALAGAESYNWIMF 315 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 S + V + + L + + R A+G TA AL P +E LL Sbjct: 316 TSVNGVEYFFNWLDRFNVDIRRFHAARIAAVGPRTAEALRKRGLIADQLPAK-FQAEGLL 374 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + E + G++ L+ RG+ RE++ L A+G + Y+ + + Sbjct: 375 EQLEGELRPGEKVLLPRGDLAREILPRELKAKGLVPVELDVYETVIADSQDEQAFEWIRN 434 Query: 177 REVTMVVVTSGEMLQQLWSLI---PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 RE+ + TS + L L+ L ++ + +K A E G Sbjct: 435 REIHAITFTSSSTVTNLLELLRRNGFEDPVAQLAGIDVVSIGPVTSKTASEAGLSVTLEP 494 Query: 234 DNADNDALLRAL 245 +NA +AL+ AL Sbjct: 495 ENATIEALVEAL 506 Score = 40.6 bits (94), Expect = 0.046, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 47/135 (34%), Gaps = 4/135 (2%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE---AM 172 L+ E + + G R L+ R + D + G E + + A E Sbjct: 244 LKWYEKKPLFGVRVLVTRARAQASDLADRIEELGGEPCELPVIETREPRDEAAVEGIRTA 303 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWY-REHWLLHCRLLVVSERLAKLARELGWQDIK 231 A ++ TS ++ ++ + ++ R+ V R A+ R+ G + Sbjct: 304 LAGAESYNWIMFTSVNGVEYFFNWLDRFNVDIRRFHAARIAAVGPRTAEALRKRGLIADQ 363 Query: 232 VADNADNDALLRALQ 246 + + LL L+ Sbjct: 364 LPAKFQAEGLLEQLE 378 >UniRef50_C7N5L1 Uroporphyrin-III C-methyltransferase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N5L1_SLAHD Length = 546 Score = 171 bits (434), Expect = 2e-41, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 85/259 (32%), Gaps = 15/259 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR LR LG P IE + + + + D L S Sbjct: 284 RIVVTRSRTQAGTFSVLLRDLGADVVEIPTIEICDPSSFDVIDAAIERIADYDWLVFTSV 343 Query: 62 HAVAFAQSQLHQ-------------QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQD 108 + V +L + +D + AIG TA AL P + Sbjct: 344 NGVDRFFKRLAEPCASAVGGSPKQTRDTRTLAGLRVAAIGPATADALTRHGIMPDAVPGE 403 Query: 109 REISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDG 167 V + AG + LI R RE + + L G E T Y+ R Sbjct: 404 YRAEAVFDAMRAAGLAAGDKILIARAKEARETLPEMLAEAGCEATVAPVYETRRPADEQT 463 Query: 168 AEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW 227 AE R EV V TS + L +++ + E L L + + +LG Sbjct: 464 AELCGRIVNGEVDAVTFTSSSTARNLVAMLGEGAVET-LSKLDLFSIGPITTQTLAKLGL 522 Query: 228 QDIKVADNADNDALLRALQ 246 ++ AD L+ ++ Sbjct: 523 TNVHQADTYTIPGLVACIR 541 >UniRef50_A7GTE4 Uroporphyrinogen III synthase HEM4 n=72 Tax=Bacillus cereus group RepID=A7GTE4_BACCN Length = 252 Score = 169 bits (429), Expect = 7e-41, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 93/246 (37%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR ++ + +R + PL+ G +L L D + S+ Sbjct: 8 KVLVTRARHQAGQMSAAVRKESGIPMEIPLLR-MDGVSQEKLQSVAKQLHVYDWIIFTSK 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F +HQ K P A+G TA L Q P ++E + + Sbjct: 67 NGVRFFLEAIHQ---KLPPAVKIAAVGIKTAQELEARGYQVHFVPT-AFVAET-FAMEFV 121 Query: 122 QNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 Q + G +R L +GN R++I L V Y+ + Q+ ++ Sbjct: 122 QTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYETKLNDEKKEDLIAALQSNQID 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TS + L+ W+ C + + K AR+ ++++ V + ++ Sbjct: 182 VITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKY-FKNVLVPEEYTIES 240 Query: 241 LLRALQ 246 L++ + Sbjct: 241 LIQCIS 246 >UniRef50_D1VCA0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Frankia sp. EuI1c RepID=D1VCA0_9ACTO Length = 617 Score = 169 bits (428), Expect = 8e-41, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 94/251 (37%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R L LR+ G P I P + + + L G + Sbjct: 343 TVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFT 402 Query: 60 SQHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV Q ++ ++ AIG TA AL + + L P ++ SE LL Sbjct: 403 SVNAVKAVQEKVEERSLDARSFAGVKVAAIGEATAEALRSFGIRPDLVPAGQQSSEGLLA 462 Query: 118 -LPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 PE + R L+ R + E++ L RG +V Y+ A Sbjct: 463 DWPEYDSSLDLLDRVLLPRADIATEILEAGLKERGWQVDDVTAYRTVRAAPPPAPIREAL 522 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V VV TS ++ L + + + + + + A+ A+ELG + A Sbjct: 523 KGGRVDAVVFTSSSTVRNLVGIAGKPHET-----TVIACIGPKTAETAQELGLRVDVEAP 577 Query: 235 NADNDALLRAL 245 A +L+ AL Sbjct: 578 EATIASLVTAL 588 >UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZQM0_9PLAN Length = 485 Score = 169 bits (428), Expect = 8e-41, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 95/247 (38%), Gaps = 9/247 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP E+L L LG + P I+ SP + D + L + + L S Sbjct: 240 RILITRPEHQAEDLAHTLAELGADVYLQPAIQISPPSDWTPVDDAIRRLHDFEWLVFSST 299 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + +L + AIG TA L + + P + ++ L Sbjct: 300 NGVRYFLDRLFASGEDLRAVGHLHIAAIGPGTADMLAKYHLKADVIPAEYRAESLVEAL- 358 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 +R L+ R + GR+++ L A G EVT YQ E W + + Sbjct: 359 -QATTDRQRFLLPRASRGRDVLPTGLAAGGGEVTEIVVYQSDDCMTLSPEIIEAWDDQPI 417 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+VTS + + L+ ++ + + +S + RE G + A D Sbjct: 418 DYVIVTSSAIARATVRLLGARAQQ-----TKFVSISPITSDALREAGVEPNIEAAVYTMD 472 Query: 240 ALLRALQ 246 ++ ALQ Sbjct: 473 GIVAALQ 479 Score = 49.5 bits (117), Expect = 1e-04, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 41/122 (33%), Gaps = 1/122 (0%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 G+R LI R E + TL GA+V Q + + + +V + Sbjct: 238 GQRILITRPEHQAEDLAHTLAELGADVYLQPAIQISPPSDWTPVDDAIRRLHDFEWLVFS 297 Query: 186 SGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 S ++ L + H + + A + + + + ++L+ A Sbjct: 298 STNGVRYFLDRLFASGEDLRAVGHLHIAAIGPGTADMLAKYHLKADVIPAEYRAESLVEA 357 Query: 245 LQ 246 LQ Sbjct: 358 LQ 359 >UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase n=12 Tax=Cyanobacteria RepID=B0C0D5_ACAM1 Length = 542 Score = 166 bits (422), Expect = 4e-40, Method: Composition-based stats. Identities = 50/251 (19%), Positives = 98/251 (39%), Gaps = 8/251 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR + L ++G P +E P L +A+L D L S Sbjct: 285 TILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPSSWKALDGAIASLDRFDWLILTSA 344 Query: 62 HAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L D + +GR TA L + P + +++ L++ Sbjct: 345 NGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKADYIPPN-FVADALVEHF 403 Query: 120 ELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + G+ L R +GGR+++ LT +GA V YQ + + + Sbjct: 404 PGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQT 463 Query: 179 VTMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 V +V S + ++ + L+ + + WL ++ + + + +EL + A+ Sbjct: 464 VDIVTFASSKTVRYFYQLLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAE 523 Query: 235 NADNDALLRAL 245 D L +++ Sbjct: 524 EYTLDGLTQSI 534 Score = 50.6 bits (120), Expect = 4e-05, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 44/133 (33%), Gaps = 1/133 (0%) Query: 112 SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 S L +AGK L+ R + +L + GA V + A + Sbjct: 269 SMGATSLQSTLPLAGKTILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPSSWKALDG 328 Query: 172 MRWQAREVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 +++TS + + L L ++ VV + AK + G + Sbjct: 329 AIASLDRFDWLILTSANGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKAD 388 Query: 231 KVADNADNDALLR 243 + N DAL+ Sbjct: 389 YIPPNFVADALVE 401 >UniRef50_Q8GCA7 Uroporphyrinogen III synthase n=1 Tax=Bacillus megaterium RepID=Q8GCA7_BACME Length = 257 Score = 166 bits (420), Expect = 8e-40, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 100/249 (40%), Gaps = 12/249 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+TR + ++++ LG + P++ F+ ++ D L ++ D + SQ Sbjct: 11 KVLITREAKQAHSFAAQIKKLGGIPLSLPVLTFARSNNEKEVEDVLLSIDCFDWIVFTSQ 70 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + ++F L + + W L A+G TA L L P++ ++E LL+ Sbjct: 71 NGISFFFEWLKELNISWSALKRLKVAAVGEKTAKLLEKHDVNVQLVPKE-YVAESLLESL 129 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + +R L++RG R ++ D L EVT YQ + D + + Sbjct: 130 KANVSHHERVLLVRGQLARSVLKDGLKE--CEVTDLVVYQTIR-NQDSERLVKQHVETGI 186 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLL---HCRLLVVSERLAKLARELGWQDIKVADNA 236 + TS ++ + +WL +++ + ++ A E G + V + Sbjct: 187 DAITFTSSSTVRFFVESVKDI--PNWLELINRTKVVCIGPITSQTASEYGIKH-LVPNTY 243 Query: 237 DNDALLRAL 245 + ++ L Sbjct: 244 TINGMIDML 252 >UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Rhodopirellula baltica RepID=Q7UPD0_RHOBA Length = 510 Score = 166 bits (420), Expect = 8e-40, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 97/246 (39%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP +L L LG P I+ P ++ + + D L S+ Sbjct: 265 NVLVTRPKDQANQLAKPLEELGANVIVQPAIKICPPDDWSEVDAAIDQIETFDSLVFTSR 324 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L R L +G TA L T + P + ++ LL Sbjct: 325 NGVKSFLDRLLDVGRDMRCLGGLKIAVVGDATANVLATYHLRADWIP-ESFDADALLTTL 383 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + K L++R GR+++ D L A G +V Y+ + + + + Sbjct: 384 QNAEPPLKSTLVVRTQRGRDVVTDGLRASGTQVREVVAYENWDVPEMDPATRGKIDEQPL 443 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + +TS + + + + E R+ V+S A+ RELGW+ VA +A Sbjct: 444 DWITLTSPATARNVHRWLGDFIGE-----TRIAVISPLTAQTVRELGWRVDAVAASATMQ 498 Query: 240 ALLRAL 245 +L +A+ Sbjct: 499 SLTQAI 504 Score = 47.1 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 26/124 (20%), Positives = 44/124 (35%), Gaps = 1/124 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 ++GK L+ R + L GA V + C +A Q +V Sbjct: 261 LSGKNVLVTRPKDQANQLAKPLEELGANVIVQPAIKICPPDDWSEVDAAIDQIETFDSLV 320 Query: 184 VTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 TS ++ L+ L ++ VV + A + + + ++ D DALL Sbjct: 321 FTSRNGVKSFLDRLLDVGRDMRCLGGLKIAVVGDATANVLATYHLRADWIPESFDADALL 380 Query: 243 RALQ 246 LQ Sbjct: 381 TTLQ 384 >UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta proteobacterium KB13 RepID=B6BVM6_9PROT Length = 247 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 106/242 (43%), Gaps = 5/242 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++ TR S + +++ + +P IE P P++ + + + +S Sbjct: 3 NLIATRSSLQNQSIINFFKGSSLNVIDYPFIEIEPIFSTPEIKKIIDDMHLFSKIIFISS 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A + K+ FAIG TT L + + I P D+ S+ LL+LPE+ Sbjct: 63 NAAQCFKIISEHHSIKFSDNVQIFAIGPTTKKEL-SFLKKNIFSPIDQFDSKTLLELPEI 121 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 QN+ + LI+RG GG+EL+ + L + A + + ECYQR D + +E Sbjct: 122 QNVKDESILIVRGVGGKELLKNELEKKQANIAYLECYQRIFKLID-FNIITNYSQKETLY 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLL--HCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++TS ++ Q + + + H +V E +AK DIK+ D + Sbjct: 181 ILITSSQIAQHFIDQLGLFGNPDQIHFDHICFIVNHENIAKELSVFEC-DIKITPTLDPE 239 Query: 240 AL 241 L Sbjct: 240 KL 241 >UniRef50_D0WES9 Siroheme synthase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WES9_9ACTN Length = 548 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 79/249 (31%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR RL LG P I+ +P + L L AL + S Sbjct: 284 RILVTRSRTQASAFTRRLEALGAQVVEVPTIDIAPPESFDALDASLNALDGFSWVVFTSA 343 Query: 62 HAVAFAQSQLHQQ-----DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 + V +L ++ D + AIG TA AL + P + V Sbjct: 344 NGVEAFFERLRRRTALPHDARALAHARIAAIGPATADALRAHGIEADAVPHEYRAEAVFD 403 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + E A LI R RE + + L G VT Y+ A Sbjct: 404 AMRERGLDADDAVLIPRAQVAREALPEMLAGIGCAVTVAPAYRTVVPGTSADAARAA-LA 462 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 V V TS + L +L+ + L RL + LG+ A + Sbjct: 463 DGVDAVTFTSSSTAENLVALLGE-DAPALLADARLFSIGPITTATLERLGFPPASTASSY 521 Query: 237 DNDALLRAL 245 L+ L Sbjct: 522 TIPGLVDTL 530 Score = 48.7 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 26/135 (19%), Positives = 45/135 (33%), Gaps = 4/135 (2%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + G+R L+ R L A GA+V A +A Sbjct: 272 LSWFEDAPLFGRRILVTRSRTQASAFTRRLEALGAQVVEVPTIDIAPPESFDALDASLNA 331 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQ----WYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + VV TS ++ + + + + L H R+ + A R G + Sbjct: 332 LDGFSWVVFTSANGVEAFFERLRRRTALPHDARALAHARIAAIGPATADALRAHGIEADA 391 Query: 232 VADNADNDALLRALQ 246 V +A+ A++ Sbjct: 392 VPHEYRAEAVFDAMR 406 >UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus sp. NRRL B-14911 RepID=Q2B6K9_9BACI Length = 259 Score = 164 bits (415), Expect = 3e-39, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 87/244 (35%), Gaps = 5/244 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LV R +R+ G + PL+ F P + ++ + L D + S+ Sbjct: 12 KVLVPRGKDQAGPFSELIRSYGGIPVEIPLLAFRPAEVTEEILHAVRELPTYDWVIFTSK 71 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A+ S + P AIG T A P++ +E + Sbjct: 72 NALETFISFAGRNAVF----PKIAAIGTKTERAAEESGLAVSFTPEE-FAAEGFIDEFLP 126 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G + LI +GN R I D L GAE Y+ G + A+ + + + Sbjct: 127 FVEKGMKVLIPKGNKARSYIADELKRAGAEPQEIIIYETGFPEDSGEKLAVMLKNGSLDV 186 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS ++ ++ + E + C + + K A ELG V + L Sbjct: 187 LAFTSPSTVEHFMEIVRKTGAEAAIKGCLVACIGPVTQKRAEELGLGVHVVPAGYTIEDL 246 Query: 242 LRAL 245 +++ Sbjct: 247 AKSI 250 >UniRef50_B2UQJ4 Uroporphyrin-III C-methyltransferase n=6 Tax=Bacteria RepID=B2UQJ4_AKKM8 Length = 506 Score = 163 bits (412), Expect = 7e-39, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 90/251 (35%), Gaps = 13/251 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR EL +RLR LG P+I +P + A+ + D L S Sbjct: 256 RIVVTRTRAQAGELSARLRRLGAEVLEMPVIRIAPPSNRREFAESVVHAHTYDWLVFSSP 315 Query: 62 HAVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL--- 116 + V +D + AIG T L + P+ ++E L+ Sbjct: 316 NGVERFFQAFFAVYRDIRSIGGARIAAIGPGTEAKLREYGLAVDVMPKK-FVAEGLVKAF 374 Query: 117 --QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 E+ I L +RG R +I D L A GA V C Y+ A D A + Sbjct: 375 RDAREEIGTIEHSTFLWVRGEEARRVIYDGLNALGAIVDECIAYKTEAETEDVAGAQAAF 434 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + R +V TS + + L W CR + +ELG A Sbjct: 435 RERGADIVTFTSSSTAENFFKL-----GLPWPEGCRAASIGPVTTATLKELGHAPSITAK 489 Query: 235 NADNDALLRAL 245 D + L+ A+ Sbjct: 490 THDINGLVEAI 500 >UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobacteria RepID=HEM4_SYNE7 Length = 264 Score = 162 bits (411), Expect = 8e-39, Method: Composition-based stats. Identities = 58/251 (23%), Positives = 101/251 (40%), Gaps = 9/251 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL TR + ++LR G P +E P L + +AA+ + D L S Sbjct: 10 TILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIADFDWLILASA 69 Query: 62 HAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV Q +L Q + W +P +G+ TA L G+ P + ++ P Sbjct: 70 NAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPEFIAESLVEHFP- 128 Query: 121 LQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 Q +AG+R L R GGRE I L ++GA V Y+ + + + + Sbjct: 129 -QPVAGQRLLFPRVETGGREQITQALQSQGAIVVEVPAYESRCPSQIPDDALIALRQAHL 187 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLV---VSERLAKLARELGWQDIKV-ADN 235 ++ TS + ++ L+ W + + + + +EL ++V A Sbjct: 188 NLISFTSSKTVRNFCQLMASNLGVDWSARISGVAIASIGPQTSITCQEL-LGRVEVEAQE 246 Query: 236 ADNDALLRALQ 246 D LL A++ Sbjct: 247 YTLDGLLLAIE 257 >UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JVU0_DESAC Length = 264 Score = 161 bits (408), Expect = 2e-38, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 89/246 (36%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR + + V L G A PLIE +L + LA L + D L S Sbjct: 10 RILVTRAAHQAQSFVRLLEAQGATAITCPLIEIVAPASWQRLDEALARLQDYDDLILTSV 69 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV S+L + L +G TA +L Q L P D +E ++ Sbjct: 70 NAVDMVFSRLGKGVVPQTALDGVRLVCVGPKTAKSLQHYGYQPDLQP-DEYRAEAVVAAL 128 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + G++ L R R+LI +LT GAEV Y+ + + V Sbjct: 129 TAEGVRGRKVLYPRAELARDLIPSSLTQAGAEVDDPIAYRTLPAKGSALQIRGLLDDKAV 188 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V +S + L+ H L + A + G D Sbjct: 189 DVVTFSSSSSVDNFVDLLGDDVTL-LTRHVVLASIGPLTTATAVKHGLAIEVEPAEYTLD 247 Query: 240 ALLRAL 245 L++AL Sbjct: 248 GLVQAL 253 Score = 44.1 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 51/123 (41%), Gaps = 1/123 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + GKR L+ R + L A+GA C + A + + ++ ++ Sbjct: 6 LTGKRILVTRAAHQAQSFVRLLEAQGATAITCPLIEIVAPASWQRLDEALARLQDYDDLI 65 Query: 184 VTSGEMLQQLWSLIPQW-YREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 +TS + ++S + + + L RL+ V + AK + G+Q D +A++ Sbjct: 66 LTSVNAVDMVFSRLGKGVVPQTALDGVRLVCVGPKTAKSLQHYGYQPDLQPDEYRAEAVV 125 Query: 243 RAL 245 AL Sbjct: 126 AAL 128 >UniRef50_Q9K8G1 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus halodurans RepID=Q9K8G1_BACHD Length = 253 Score = 160 bits (405), Expect = 4e-38, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 91/243 (37%), Gaps = 8/243 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+TR L + G V PL+ F + + + A++ + + S + Sbjct: 11 VLITRAKEQASSLSRLIEEAGGVPIEVPLLSFIKTMDVYE--EVGASIQSYEWIVFTSAN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV F + +Q+ K +LP A+G +T L L P + ++E L++ + Sbjct: 69 AVRFFFNTWPRQELK--KLPSIAAVGSSTQRELSRYGISVDLMPNE-YVAESLVETMV-K 124 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + R L +GN R + L G V Y+ +Q + ++ Sbjct: 125 RLKPCRVLFPKGNLARPTVKVGLETNGFIVDEMTVYETKRPLEAKVMLCEAFQKHRIEII 184 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 TS + +L+ + + H H + A A++ G VA + L+ Sbjct: 185 TFTSPSAVDHFVTLLDREFILH--EHLLYAYIGPIAAARAKQRGLPVHIVAKTYTGEGLV 242 Query: 243 RAL 245 A+ Sbjct: 243 NAI 245 >UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R7V5_9PLAN Length = 505 Score = 160 bits (405), Expect = 4e-38, Method: Composition-based stats. Identities = 60/246 (24%), Positives = 91/246 (36%), Gaps = 9/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP+ E L L LG P I + L + L D L S Sbjct: 260 TVLVTRPAQQAESLARPLEELGAAVLLDPAIVIGMPEDSAPLVQAIHTLETYDWLVFASA 319 Query: 62 HAVAFAQSQLHQQDRKWPRLPDY--FAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V QL +L +G T+ AL + + L P++ E +E L + Sbjct: 320 SGVEKFFEQLISLGYDLRKLAHIRLAVVGSGTSAALEKLHLRADLVPENFE-AESLAAML 378 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + AGKR LI+R + GRE++ L GA V Y+ R R++ Sbjct: 379 APEA-AGKRVLIVRASRGREVLPQLLANSGAGVEQVVAYESVDNLVPDPLVVQRLTERKI 437 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + VTS + L + L +L +S + R LG + A Sbjct: 438 DYISVTSSAIATSLVNRYGD-----LLRSAKLASLSPITSATIRSLGHEVAVEATLYTMA 492 Query: 240 ALLRAL 245 L+ A+ Sbjct: 493 GLVEAI 498 >UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Leptothrix cholodnii SP-6 RepID=B1Y161_LEPCP Length = 267 Score = 158 bits (400), Expect = 2e-37, Method: Composition-based stats. Identities = 70/254 (27%), Positives = 106/254 (41%), Gaps = 16/254 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQL-AALGESDLLFALSQ 61 +LVTRP P +E V RLR LGQ A PL+ P L + ++ +S Sbjct: 12 LLVTRPQPQADEWVERLRGLGQPACAAPLMVIEPVAAFAAAVQAAWQRLADCRMVMFVSP 71 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY-----PQDREISEVL- 115 +AV +Q WP A G T AL + D+ +E L Sbjct: 72 NAVLQFFAQ-RPAGLPWPTDTLAAATGPGTVAALQSKGVAAAQIVAPAADADQFDAETLW 130 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMR 173 LQ E Q AG++ LI+RG GR+ + TL GA+V Y+R A + G + R Sbjct: 131 LQRLESQTWAGRQVLIVRGEDGRDWLASTLRHHGAQVDLLAAYRRTAPAWSGELLDLLQR 190 Query: 174 WQAREVT-MVVVTSGEMLQQLWSLIPQWYREHW--LLHCRLLVVSERLAKLARELGWQDI 230 + R + +S + + L + + Q + W L + R+A+ A LGW+ + Sbjct: 191 VRQRPQDYAWLFSSSQAIGHLAAFM-QTAPQAWRALHDVPAVATHLRIAQTATSLGWRTV 249 Query: 231 KVADNADNDALLRA 244 + AL+ A Sbjct: 250 L--PLTPDAALIAA 261 >UniRef50_C8WIZ1 Uroporphyrin-III C-methyltransferase n=10 Tax=Bacteria RepID=C8WIZ1_EGGLE Length = 522 Score = 158 bits (399), Expect = 2e-37, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 81/250 (32%), Gaps = 7/250 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++ VTR L RLR LG P+I + + + L + S Sbjct: 263 TVAVTRTRAQASGLTERLRALGASVIELPVISIAAPSSFSGVDSCIERLAGYRFVVFTSA 322 Query: 62 HAVAFAQSQ--LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + L D + AIG TA L L P + +E + L Sbjct: 323 NGVKAFFERLVLAGLDARALACARIAAIGPATAAELAERGIVADLVPGE-FRAEAVADLL 381 Query: 120 ELQNIA-GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR-WQAR 177 + G L+ R R+++ L A GA V Y+ AE A+ A Sbjct: 382 IEAGLTDGDWVLVPRALEARDVLPRMLRACGARVDVVPVYRTVPPSRASAEPALASLIAG 441 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 E V TS ++ L+ L + AR+ + A+ Sbjct: 442 EADAVTFTSSSTVRNFVGLVRDVAPNPVEVLERLDFYSIGPITTTTARDESLRIAAQAEA 501 Query: 236 ADNDALLRAL 245 D L+ A+ Sbjct: 502 YTIDGLVEAI 511 >UniRef50_A9B548 Uroporphyrinogen III synthase HEM4 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B548_HERA2 Length = 266 Score = 157 bits (398), Expect = 3e-37, Method: Composition-based stats. Identities = 51/249 (20%), Positives = 88/249 (35%), Gaps = 9/249 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++TR E L G + I+ P L+ + D + A S Sbjct: 11 RIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMIATST 70 Query: 62 HAVAFAQSQ--LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + + AIG+ TA L P ++E L Sbjct: 71 NAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPH-AYVAEQFLV-- 127 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E Q+IAG+R + + + R L+ + L RGA+VT Y+ A A + + V Sbjct: 128 EFQDIAGQRIFLPQADIARPLLREALIERGADVTAVVAYRTVPDPQVVA-LAELLRQQRV 186 Query: 180 TMVVVTSGEMLQQLWSLI---PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +V TS ++ + + +L + + ++ A ++G A Sbjct: 187 DVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVDIEAAEH 246 Query: 237 DNDALLRAL 245 L+ AL Sbjct: 247 STQGLVEAL 255 Score = 42.5 bits (99), Expect = 0.012, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 37/120 (30%), Gaps = 1/120 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + GKR ++ R L GAE +C Q + Q ++ Sbjct: 7 LTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMI 66 Query: 184 VTSGEMLQQLWSLIP-QWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 TS ++ + + L ++ + + AKL + G V + L Sbjct: 67 ATSTNAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAYVAEQFL 126 >UniRef50_D2M0D2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M0D2_BACS4 Length = 257 Score = 156 bits (396), Expect = 4e-37, Method: Composition-based stats. Identities = 38/246 (15%), Positives = 96/246 (39%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L TR L L G PLI P++ + + + D + S Sbjct: 9 TLLNTRAIHQAAPLTKYLEKHGGNVVEIPLISMKKTSD-PKIKEAIKMIHTYDYIVFTST 67 Query: 62 HAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 ++++F L +Q + + +G++T +L+ + P +E L Sbjct: 68 NSISFFLEILKEQGLSKREICNMKFAVVGKSTLRSLNKEGFDADIIPPI-FDAEHLASAL 126 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + AG++ L + + R+++ L G ++ Y+ D A+ + + Sbjct: 127 KTELSAGEKVLYPKSDLARDVLTRELHKVGIQIDDPSVYETVFRIDDKAKLNELIKKNLI 186 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++ TS + +S + + + + V+ ++ ++ G +++ + + Sbjct: 187 HIIIFTSPSTVHSFFSQVDKEVVMNNVDKLHFAVIGSVTSRALKDEGIEEMIIPKEFTTE 246 Query: 240 ALLRAL 245 AL+ A+ Sbjct: 247 ALVHAI 252 >UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella RepID=Q2KYG5_BORA1 Length = 266 Score = 156 bits (396), Expect = 4e-37, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 85/223 (38%), Gaps = 15/223 (6%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 ++TRP E L RLR G P + + DL+ +S +A Sbjct: 13 VLTRPEGRNEALAGRLRAAGWEVCVLPALRIVALPAPRA-----PRPEDYDLVVFVSGNA 67 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVS----GQKILYPQ---DREISEVLL 116 Q++ WP +G +A AL +LYP SE L Sbjct: 68 ARLYLKQVYASAGAWPAATVAATVGPGSAQALFESGYFGANTTVLYPDISAPTHDSEALW 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE--AMRW 174 Q+ Q +R L++RG GR + + L GA+VT YQR +D A W Sbjct: 128 QVLSAQGALPRRVLLVRGTQGRNWLAERLREAGAQVTAYAAYQRLPAQWDAATLDALRAW 187 Query: 175 -QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSE 216 + V ++TSGE + + + I + W +CR ++ Sbjct: 188 ARQGRVATWLLTSGESIDAVAAQIARADLLSWWRNCRYVITHP 230 >UniRef50_C2WCN0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Bacillus RepID=C2WCN0_BACCE Length = 254 Score = 154 bits (390), Expect = 2e-36, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 88/246 (35%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+TR ++ ++ + PL+ G + D + S+ Sbjct: 8 TVLITRAKHQARQMSVAVKKESGIPMEIPLLRME-GVSQQVFQSVSQQIHLYDWIIFTSK 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V+F L + P A+G T L + P ++E + Sbjct: 67 NGVSFFLDGL---GERIPSTVRIAAVGVKTGQELKKRGYEVCFVPT-SFVAETFAEEFG- 121 Query: 122 QNIAGK-RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + ++GK L +GN R++I L G + Y+ + + ++ ++ Sbjct: 122 RKLSGKEHILFPKGNLARDVIPTKLRELGVLLEEFVVYETKTNDTKQQDLIVALESGKID 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS ++ L+ W+ C + + + AR + D+ V +A Sbjct: 182 VVTFTSPSTVRSFVKLLEGTNWREWIKKCTIACIGPITEQEARRY-FADVIVPKEYTIEA 240 Query: 241 LLRALQ 246 L++ + Sbjct: 241 LIQCIS 246 >UniRef50_Q2JFR9 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=3 Tax=Frankia RepID=Q2JFR9_FRASC Length = 607 Score = 153 bits (388), Expect = 4e-36, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 90/251 (35%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R L LR+ G P I P + + + L G + Sbjct: 332 TVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFT 391 Query: 60 SQHAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV Q ++ D + AIG TA AL T + L P ++ SE LL Sbjct: 392 SVNAVKAVQEKVEERSLDARAFAGVKVAAIGEATADALRTFGIRPDLVPSGQQSSEGLLA 451 Query: 118 ---LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + R L+ R + E + L RG +V Y+ A Sbjct: 452 DWPDFDDTLDLLDRVLLPRADIATETLVAGLKERGWQVDDVTAYRTVRAAPPPASIREAL 511 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V VV TS ++ L + + + + V+ A A+ELG + A Sbjct: 512 KGGRVDAVVFTSSSTVRNLVGIAGKPHET-----TVIAVIGPATAATAQELGLRVDVQAP 566 Query: 235 NADNDALLRAL 245 A AL+ AL Sbjct: 567 EASIPALVGAL 577 >UniRef50_A9GHX2 Uroporphyrinogen-III synthase n=3 Tax=cellular organisms RepID=A9GHX2_SORC5 Length = 534 Score = 153 bits (388), Expect = 4e-36, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 91/254 (35%), Gaps = 11/254 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP +R G A P I+ P ++ + + L + S+ Sbjct: 265 RVLVTRPRHQARSTSRLVRLRGGEAVELPTIDIHPPPDPARVTEAVRGLSGYHAVVFTSE 324 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + VA ++ + AIG TA AL + + P++ E+ + Sbjct: 325 NGVACFFKEMDRLGLDARAFGPARLAAIGVGTAAALAARGVRADIVPREFRGEELAEAIL 384 Query: 120 ELQNIAGK-------RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEA 171 +AG+ R L+ R RE++ + L A G EV Y+ E Sbjct: 385 ADPALAGRRAASPRVRVLLARALVAREVLPERLRAAGCEVDVVPVYETRPASAGRREELL 444 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 A + +V++TS + L L+ + L L + A + G + Sbjct: 445 RALSAGAIDVVLLTSSSTVDSLCDLLGEGAAAR-LERVLLASIGPITTATAEKRGLRIGV 503 Query: 232 VADNADNDALLRAL 245 A+ + LL AL Sbjct: 504 TAEVSTTAGLLDAL 517 >UniRef50_C1F250 Uroporphyrinogen-III synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F250_ACIC5 Length = 275 Score = 153 bits (388), Expect = 4e-36, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 91/257 (35%), Gaps = 15/257 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR L L +LG P I P L L L D + S Sbjct: 15 RILVTRAEHQAGRLSHILASLGAEPVEVPAIRILPPDTYEPLDHALRTLSSYDWIILTSA 74 Query: 62 HAVAFAQSQLHQQDRKWP----------RLPDYFAIGRTTALALHTVSGQKILYPQDREI 111 + V S++ Q P +P A+G +TA A V L P D+ + Sbjct: 75 NTVNAMLSRIEQLGMVSPASQTGQAIYGPMPKIAAVGPSTAKAAARVRWNIDLMP-DKYV 133 Query: 112 SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 +E LL+ + G+R L+ R + R++I + L +G + E Y+ A+ Sbjct: 134 AESLLEALG-DKLRGQRVLLARSSRSRDVIPEALREQGVNLDVVEAYRTEIPEESLAQIR 192 Query: 172 MRWQAREVTMV---VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ 228 + + TS + + L+ + + +K R+ W+ Sbjct: 193 TLFGDGRPHGLAAATFTSSSTVDNFFKLMRASGLAFVPSTLPAISIGPITSKTLRDHAWE 252 Query: 229 DIKVADNADNDALLRAL 245 AD D L+ A+ Sbjct: 253 PSAEADPHSVDGLVDAV 269 Score = 41.0 bits (95), Expect = 0.040, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 43/133 (32%), Gaps = 9/133 (6%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q ++G+R L+ R + L + GAE + + Sbjct: 9 QPLSGRRILVTRAEHQAGRLSHILASLGAEPVEVPAIRILPPDTYEPLDHALRTLSSYDW 68 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHC---------RLLVVSERLAKLARELGWQDIKV 232 +++TS + + S I Q ++ V AK A + W + Sbjct: 69 IILTSANTVNAMLSRIEQLGMVSPASQTGQAIYGPMPKIAAVGPSTAKAAARVRWNIDLM 128 Query: 233 ADNADNDALLRAL 245 D ++LL AL Sbjct: 129 PDKYVAESLLEAL 141 >UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured marine bacterium 106 RepID=Q6SHZ5_9BACT Length = 275 Score = 151 bits (381), Expect = 3e-35, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 101/249 (40%), Gaps = 6/249 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + LVTR L L + G + + P + + + + + D S Sbjct: 17 LRFLVTRLDSTESSLSGMLESQGASVLTAQMTQIIPTESWESFDETVQQISKIDWAVFTS 76 Query: 61 QHAVAFAQSQLHQQD---RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 ++ V S+L+ + ++ +G+ TA L L P + SE L+ Sbjct: 77 RNGVTHCLSRLNDLEVSAQQLFSSIKTACVGQATASVLTDNGITPELVP-EHFQSEGLIY 135 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + ++ KR +++ R+++ D+L GA++ Y+ + D + + Sbjct: 136 AFKQHDLFEKRCWLIQAESPRKILQDSLQKMGAQIILTPVYRNVPVAGDYTFLLTELEQQ 195 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++ ++ S +Q ++P + E ++ + + AK AR+ GW ++VA N Sbjct: 196 KLDWILFASPSAVQNFHQILPSGFWESLAAEPKIACLGKITAKAARDFGWS-VQVAPNIQ 254 Query: 238 N-DALLRAL 245 + L+++L Sbjct: 255 DFQHLVQSL 263 >UniRef50_A0QR19 Uroporphyrinogen-III synthase n=10 Tax=Actinomycetales RepID=A0QR19_MYCS2 Length = 610 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 85/251 (33%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R E+ RL T G + P I P + Q+ + L G + Sbjct: 342 TVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFT 401 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL- 116 S +AV + ++ +G+ TA + L P + S LL Sbjct: 402 STNAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLD 461 Query: 117 QLPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + P + R L+ R + E + + L RG E+ Y+ A Sbjct: 462 EFPPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMI 521 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V TS ++ L + + + + + + A+ A E G + + Sbjct: 522 KTGGFDAVCFTSSSTVRNLVGIAGKPHA-----RTIVACIGPKTAETAIEFGLRVDVQPE 576 Query: 235 NADNDALLRAL 245 A L+ AL Sbjct: 577 TAAVGPLVEAL 587 >UniRef50_Q7NL92 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Gloeobacter violaceus RepID=Q7NL92_GLOVI Length = 508 Score = 150 bits (380), Expect = 4e-35, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 88/247 (35%), Gaps = 5/247 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTR + ++L LG P + + L +A L L S + Sbjct: 247 ILVTRAADQAGGFSAQLEALGASVLEMPALVVTAPTSWEPLDRAIAQLAGYRWLLLTSAN 306 Query: 63 AVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V ++L R L A+G TA A T P +L P+ Sbjct: 307 GVEAFFARLTHHRRDLRALGGVRVAAVGPKTAQAARTHGLICDFVPGQYVSDGLLTDFPD 366 Query: 121 LQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + I G+R L +R +GGRE I + GA V Y +A + Sbjct: 367 IAGIYGERVLFVRVESGGRETITEQFRRWGALVDEVAGYATGCPDSAEPGCVAALRAGRI 426 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE-LGWQDIKVADNADN 238 S + ++ L+ E L R+ + + + RE LG D++ A+ Sbjct: 427 DCATFASAKTVRHFARLLQGEELESLLRKVRIASIGPQTSAACRETLGRVDVE-AEVFTL 485 Query: 239 DALLRAL 245 D L +A+ Sbjct: 486 DGLAQAI 492 >UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=1 Tax=Acinetobacter sp. ADP1 RepID=Q6FFA8_ACIAD Length = 256 Score = 149 bits (378), Expect = 6e-35, Method: Composition-based stats. Identities = 55/228 (24%), Positives = 88/228 (38%), Gaps = 11/228 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ++ TRP+ +EL + G + PL+ L L +S L+ +S Sbjct: 1 MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L + + L + A+G++TA AL + E SE +LQL Sbjct: 61 PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGISAEI--PQVETSEGMLQL 118 Query: 119 PELQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW--- 174 P Q + ++ RG GGR+L+ L +G + Y R + Sbjct: 119 PVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDRQCPESATQKILSIAHDI 178 Query: 175 -QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKL 221 Q ++ V++TS SLI C LV+ ERL ++ Sbjct: 179 VQDKQPVWVLITSEASWLNWLSLIQPHAG--LFQDCHYLVLGERLEQI 224 >UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4E5B Length = 513 Score = 149 bits (377), Expect = 7e-35, Method: Composition-based stats. Identities = 62/249 (24%), Positives = 95/249 (38%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LVTRP+ +V +L LG V P +E + L L GE D L Sbjct: 260 RVLVTRPAHQAGGMVRKLEHLGAVVSRLPAVEIRDVDNFASVDRALGQLRHGEWDWLVFT 319 Query: 60 SQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S + V +L R L AIG TA +L + + P SE L Sbjct: 320 SANGVHALLRRLDTIGRDLRDLGGVKLAAIGPKTAESLREYRLRADVVPDTTFSSEGLAG 379 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + +AG+R L+ R N GREL+ L A+ A V Y + + + Sbjct: 380 ALKPH-VAGQRVLLARANRGRELLRTEL-AKVATVEQVTVYDQVDVTAPEGAVLDALRRG 437 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLL-HCRLLVVSERLAKLARELGWQDIKVADNA 236 E+ V + S + + + + + +L+V+S K R LG+ A Sbjct: 438 EIRFVTLPSSSIAKGVLAAFDETINGRVERGEIKLIVISPETGKAVRALGYPVAAEATTF 497 Query: 237 DNDALLRAL 245 D L+ A+ Sbjct: 498 TEDGLIEAV 506 >UniRef50_Q3B017 Uroporphyrinogen-III synthase n=19 Tax=Cyanobacteria RepID=Q3B017_SYNS9 Length = 272 Score = 149 bits (377), Expect = 8e-35, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 89/250 (35%), Gaps = 9/250 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TR + E L G P + P L D LA L L S Sbjct: 16 TVVITRAAEQQGEAKELLEAKGANVLDLPALVIVPPDHWGPLDDALADLDNFHWLVFSSA 75 Query: 62 HAVAFAQSQLHQQDR---KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V + +L +Q R + PR A+GR TA L + P ++E L+ Sbjct: 76 NGVLAVEQRLQRQQRNLCRLPRGLKIAAVGRKTARLLEELGAPADFVPP-SFVAESLIDH 134 Query: 119 PELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + G L+ R GGR ++ D G V Y + A Sbjct: 135 FPVSGW-GLTMLLPRVQQGGRTVLADAFGEAGVRVVEVAAYDSRCPEHMAEPAATALADG 193 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQDIKVAD 234 V + TSG+ L+ + + W L ++ + + ++ RE + AD Sbjct: 194 AVDAIAFTSGKTATHTAQLMEKRFGSEWKQHLNGVAVVSIGPQTSRSCREHFGRVDAEAD 253 Query: 235 NADNDALLRA 244 D + L+ A Sbjct: 254 PHDLEGLVEA 263 >UniRef50_Q1INI7 Uroporphyrinogen-III synthase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=Q1INI7_ACIBL Length = 272 Score = 149 bits (376), Expect = 9e-35, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 88/249 (35%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LV+R L L+ G P IE Q + + ++ + D L S Sbjct: 17 RVLVSRARKQAGALSVELKARGARVLEIPFIEIREPQSFAPMDTAIRSVLDYDWLILTSV 76 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L + AIG T A+ + + P++ ++E +++ Sbjct: 77 NGVNALFRRLEKLKLRPDLFEKLKIAAIGPATKKAIEGQRLKVEVTPKE-YVAEAVVEAL 135 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA--R 177 + + GKR L++R R++I + L GA V E Y+ + + + Sbjct: 136 A-RKVKGKRVLLVRAKVARDVIPNELRRAGANVDVVEAYETVVPEKSRGKLSDALHSLKN 194 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLH-CRLLVVSERLAKLARELGWQDIKVADNA 236 + ++ TS ++ LI + R + + RE A+ Sbjct: 195 KPQVITFTSSSTVKNFVELIGKRAATKCFRDGVRSASIGPVTSATLREFNLPVNIQAEEY 254 Query: 237 DNDALLRAL 245 L+ A+ Sbjct: 255 TIPGLVAAI 263 Score = 40.2 bits (93), Expect = 0.071, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 39/127 (30%), Gaps = 1/127 (0%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E + G R L+ R + L ARGA V + + + Sbjct: 9 ETLPLKGVRVLVSRARKQAGALSVELKARGARVLEIPFIEIREPQSFAPMDTAIRSVLDY 68 Query: 180 TMVVVTSGEMLQQLWSLIPQ-WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +++TS + L+ + + R ++ + K + Sbjct: 69 DWLILTSVNGVNALFRRLEKLKLRPDLFEKLKIAAIGPATKKAIEGQRLKVEVTPKEYVA 128 Query: 239 DALLRAL 245 +A++ AL Sbjct: 129 EAVVEAL 135 >UniRef50_Q180R8 Porphyrin biosynthesis protein includes: uroporphyrinogen-III methyltransferase and uroporphyrinogen-III synthase] n=12 Tax=Bacteria RepID=Q180R8_CLOD6 Length = 502 Score = 148 bits (375), Expect = 1e-34, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 89/246 (36%), Gaps = 5/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 SI VTR LV ++ LG P I+ Q L +++ + + + L S+ Sbjct: 257 SIAVTRSRNQNSVLVEKIMDLGGNPIEIPTIKVEKIQNNINLENEIKNINKYNYLILTSK 316 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV ++++ + AIG T+ L + P+ ++E L + Sbjct: 317 NAVEIFFEKIYEMNFDLRILSNLKVCAIGSATSNELKKRGIIADIVPKK-FVAESLYEEL 375 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 LI R R+ + D L EVT Y+ E + ++ Sbjct: 376 APILNDDDNILIPRAENARDYLVDKL-KAICEVTEVHIYRTVIDEEKKGEILDILNSNDI 434 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS + L +I + + L + L + + LG + K + + D Sbjct: 435 DYITFTSSSTVNNLVEIIGKENIKI-LEKIKTLSIGPITTETINSLGIKLYKESATSTID 493 Query: 240 ALLRAL 245 +L+ + Sbjct: 494 SLVDLI 499 >UniRef50_A6C1N1 Uroporphyrin-III C-methyltransferase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C1N1_9PLAN Length = 509 Score = 148 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 90/248 (36%), Gaps = 4/248 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + I +TR E + + LG P IE S + ++ L L S Sbjct: 257 LRIGITRAEDQSETEIQQAIRLGAQPVLLPTIEISKPADQAPVDQAISRLEHYQWLVFTS 316 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V + +L + +L IG +TA AL + L P +E L + Sbjct: 317 ANGVRYFMDRLWELGFDSRQLAHLKIATIGPSTAEALLAYRLRADLTPPQYR-AEALAEA 375 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + +A + L N GRE++ L A V Y+ + E ++ E Sbjct: 376 LKPL-VAHQSLLWAGANRGREVLQTELAKVSATVEKVVVYENHDVAAWNTESLRLLESGE 434 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V V ++S + + L+ R +L +S ++ A E G Q A + Sbjct: 435 VDWVGLSSPSIARNFERLLSDAARTQLGKSIKLASISPVTSQAALEAGLQIDAEAKDYHW 494 Query: 239 DALLRALQ 246 D + A+Q Sbjct: 495 DGIFAAIQ 502 >UniRef50_C4DTF5 Uroporphyrinogen-III synthase; uroporphyrinogen-III C-methyltransferase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DTF5_9ACTO Length = 527 Score = 147 bits (372), Expect = 3e-34, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 87/251 (34%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +L+ R E+ +LR G + P I P + Q+ + L G + Sbjct: 248 KVLIPRTKEQAGEMSDKLREYGAIPCEVPTIAVEPPRTPAQMERAIKGLVDGRYAWIVFT 307 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + + +G TA + + + L P + LL+ Sbjct: 308 SANAVKAIWEKFAEHGLDARAFGGLKIACVGDATAAKVRSFGIEPELLPTGEQSGTGLLE 367 Query: 118 LPELQNI---AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + + R L+ R + E + L RG EV Y+ A+ Sbjct: 368 VFPPHDTILDPVSRVLLPRADIATEALSAGLQERGWEVDDVTAYRTVRASPPPADIRDAI 427 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++ V+ TS ++ L + + + + V+ A+ A E G + Sbjct: 428 KSGGFDAVLFTSSSTVRNLVGIAGKPHA-----RTVVSVIGPHTAETATEFGLRVDAQPQ 482 Query: 235 NADNDALLRAL 245 +A+ +L+ AL Sbjct: 483 HANMPSLVEAL 493 >UniRef50_C9Y9I3 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9Y9I3_9BURK Length = 268 Score = 147 bits (371), Expect = 3e-34, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 101/266 (37%), Gaps = 25/266 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + L G +W PLI+ P Q + + L + D + +S Sbjct: 5 MRVIITRPQAEAAPWLKALDAAGYTSWSLPLIDIRPAAQSAHVESAWSRLSDFDAVMFVS 64 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDY----FAIGRTTALALHTVSGQK--ILYPQDR---EI 111 ++AV + + F G + AL V + + P Sbjct: 65 RNAVHYFFEGKAAVAPVFTAQAAIETRAFVTGPGSYSALQRVGAEPGFVDAPDFHAGQFD 124 Query: 112 SEVLLQLPELQNIAGKRALILRGN----------GGRELIGDTLTARGAEVTFCECYQRC 161 SE L + + G R LI+RG+ GR+ + G EV F Y+R Sbjct: 125 SEALWAVVRSRVTPGYRVLIVRGSTIDEGASDEGSGRDWFALQVMDAGGEVEFVVSYERQ 184 Query: 162 AIHYDGAEEAMRWQAR-EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAK 220 +D + A A + T+ V +S E ++ L P W + +V R+ Sbjct: 185 RPQWDASTIAQAQAAATDGTVWVFSSSEAIRNLQHACP---GVSW-AQAQAVVTHARIGD 240 Query: 221 LARELGWQDIKVADNADNDALLRALQ 246 ARE G+ ++ + AL+ +++ Sbjct: 241 AAREAGFGRVRESKPLL-PALMASIE 265 >UniRef50_C1YGP0 Uroporphyrinogen-III synthase; uroporphyrinogen-III C-methyltransferase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YGP0_NOCDA Length = 562 Score = 146 bits (370), Expect = 5e-34, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 86/253 (33%), Gaps = 13/253 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R L +LR G V P I P + Q+ + L G + Sbjct: 284 RVLVPRTKEQAAALSDQLRGYGAVPEEVPTISVEPPRTPQQMERAVRGLVTGRYQWVAFT 343 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDRE-ISEVLL 116 S +AV + +L +G TA A+ Q L P + E S L+ Sbjct: 344 SVNAVRAIRERLESYGLDARAFAGVKVAVVGEATARAVREFGIQPDLAPPEEEQSSSGLV 403 Query: 117 QL--PELQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 + P I +R L+ R + E + L G EV Y+ A Sbjct: 404 SVWPPYDAEIDPIERVLLPRADIATETLSAGLDKLGWEVDDVTAYRTVRAAPPPAPVREA 463 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V+ TS ++ L + + + + V+ + A E G + VA Sbjct: 464 IKGGGFDAVLFTSSSTVRNLVGIAGKPHNT-----TVIAVIGPETERTAIEFGLRVDVVA 518 Query: 234 DNADNDALLRALQ 246 A AL +AL Sbjct: 519 PKASVSALAQALS 531 >UniRef50_A6W5L9 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase n=27 Tax=Actinomycetales RepID=A6W5L9_KINRD Length = 607 Score = 146 bits (369), Expect = 7e-34, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 88/251 (35%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R + ++L G A P I P + Q+ + L G + + Sbjct: 329 RVLVPRTKEQAGGVTAKLSDHGATAEVVPTISVEPPRTPQQMEKAVKGLVTGRYEWIGFT 388 Query: 60 SQHAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL- 116 S +AV + + + D + A+G TA AL + L P+ + + LL Sbjct: 389 SVNAVRAVREKFTEYGLDARAFSGLKVAAVGGVTADALREWGIEPDLVPEGEQSASGLLE 448 Query: 117 QLPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 P ++ R + R + + + L G EV Y+ A Sbjct: 449 AWPPYDDVLDPINRVFLPRADIATDTLVAGLQENGWEVDDVTAYRTVRAAPPAAPVRDAI 508 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + VV TS ++ L + + + + + AK A E G + +A Sbjct: 509 KTGAFDAVVFTSSSTVRNLVGIAGKPHP-----STVVACIGPATAKTAEEHGLRVDVLAP 563 Query: 235 NADNDALLRAL 245 DAL+ AL Sbjct: 564 EPSADALVDAL 574 >UniRef50_A2SK65 Uroporphyrinogen-III synthase n=1 Tax=Methylibium petroleiphilum PM1 RepID=A2SK65_METPP Length = 275 Score = 144 bits (365), Expect = 2e-33, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 100/261 (38%), Gaps = 18/261 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP E V+RL G A PLI + L + LL +S Sbjct: 1 MRVLVTRPEEQAREWVARLTERGVAAAALPLIAIEAPADPAPVRLAWQTLPQRSLLVFVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK---ILYPQD--REISEVL 115 +AV SQ +W + + G T+ AL + P D R SE L Sbjct: 61 PNAVTQFFSQ-RPAGCEWQATLRFGSPGPGTSAALRAAGVAPGAIVEPPPDAGRFDSEAL 119 Query: 116 LQLPELQ-NIAGKRALILRGN-------GGRELIGDTLTARGAEVTFCECYQRCAIHYDG 167 + Q G+ LI+RG+ GRE + L GA + Y+R D Sbjct: 120 WAVLGPQGPWQGRSVLIVRGSVDGEAQGQGREWLSQVLRDAGASIDLVAAYRRAPPRLDA 179 Query: 168 AEEAMRWQAREV---TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE 224 A +A+ A + + +S E + QL +L + L R+A+ AR Sbjct: 180 AGQALWAAALAAPVEHVWLFSSSEAIDQLDALAAAAGTAPDWRTAQALATHPRIAQRARR 239 Query: 225 LGWQDIKVADNADNDALLRAL 245 G+ + A +A++ A+ Sbjct: 240 AGFGRVIEAP-PTLEAVVAAI 259 >UniRef50_Q1D8Z7 Uroporphyrinogen-III synthase n=2 Tax=Cystobacterineae RepID=Q1D8Z7_MYXXD Length = 256 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 76/244 (31%), Gaps = 7/244 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP EEL L G PL+E P + LA + + S Sbjct: 9 RVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASP 68 Query: 62 HAVAFAQSQLHQQD-RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V L + + + +G T A + P + LL L + Sbjct: 69 TGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEG-TGAALLNLIK 127 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G L+ GR + D L G VT Y+ A+ A Sbjct: 128 DALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLAL-LDASPPD 186 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+ S + + L R++ + A LG VA+ ++ Sbjct: 187 VVLFASPRTAEAFV----EEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTPES 242 Query: 241 LLRA 244 L+ A Sbjct: 243 LVDA 246 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 41/125 (32%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + + GKR L+ R E + L GAEV + + + T Sbjct: 3 RRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTW 62 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 VV S + L + + + + ++ V R + A G + AL Sbjct: 63 VVFASPTGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAAL 122 Query: 242 LRALQ 246 L ++ Sbjct: 123 LNLIK 127 >UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=14 Tax=Acinetobacter RepID=B0VDG2_ACIBY Length = 255 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 56/258 (21%), Positives = 94/258 (36%), Gaps = 17/258 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP EL L+ G PL+E L+ L + + +S Sbjct: 1 MLFINTRPDSRAAELTHALQNKGFQVESLPLLELVAQPFSESLSQLYQQLTGAQAIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKW--PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L Q K + + A+G+ TA LH + + + E SE +L L Sbjct: 61 PTAVDVGMQYLTQSGLKIDELKHIQWIAVGQATANRLHDYGIEAHV--PEVETSEGMLNL 118 Query: 119 PELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P L + RG GGR+ + +TL +G ++ Y+R + Q Sbjct: 119 PLLHCMQKSGSVAFWRGEGGRQFMMETLQQQGIQILNFVLYRRQCPQASYSTFKHLTQNS 178 Query: 178 EVT----MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA-----RELGWQ 228 +V++TS + L + + C LV+ RL +L ++ Sbjct: 179 NYNLDKWLVLITSEASWKYWLELCLKNKAQP---DCVYLVLGPRLFQLVKDYRDQQQAHF 235 Query: 229 DIKVADNADNDALLRALQ 246 I +N ++ +Q Sbjct: 236 HIIQLENLSPSGMIHHIQ 253 >UniRef50_C5CSC8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Variovorax paradoxus S110 RepID=C5CSC8_VARPS Length = 257 Score = 144 bits (363), Expect = 4e-33, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 98/256 (38%), Gaps = 19/256 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP+ + R G A PLI P L L + L +S Sbjct: 6 VIVTRPAREAAQWADEFRAAGLDAEVLPLIAIEPAIDAEPLRAAWKRLADYAALMFVSAT 65 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY---PQD--REISEVLLQ 117 AV LH ++ + P ++A G TA AL + P D R SE L + Sbjct: 66 AVEHFF--LHAEEGQRATGPRFWATGPGTARALLRAGVPQDAIDAPPPDAARFDSEALWE 123 Query: 118 LPELQNIAGKRALILRG------NGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 + Q G R LI+RG GR+ + + A Y+R +D A A Sbjct: 124 RVKGQVGQGVRVLIVRGGDAAGQPSGRDWLAREIDAAKGLRDTVVAYRRLPPSFDDAARA 183 Query: 172 MRWQ-AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 + A + + +S E + L +P W C + R+ + AR G+ + Sbjct: 184 LALDGAAGRAVWLFSSSEAIANLCDAMPGTG---WHAACA-VATHARIGEAARAAGFGAV 239 Query: 231 KVADNADNDALLRALQ 246 +V +AL+ +++ Sbjct: 240 RVCPPL-REALVASIE 254 >UniRef50_C4GFP3 Putative uncharacterized protein n=1 Tax=Kingella oralis ATCC 51147 RepID=C4GFP3_9NEIS Length = 241 Score = 143 bits (360), Expect = 6e-33, Method: Composition-based stats. Identities = 63/238 (26%), Positives = 93/238 (39%), Gaps = 12/238 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 IL+ RP ++ G A F I +P L + + LF +S Sbjct: 4 ILLIRPENRLAADIAACTAAGWQAVPFAPIRIAPIPDT--LFRLPQTIAPAQALFWVSPT 61 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A A + K P A+G TA AL I PQ+ SE L LP Sbjct: 62 AAEIAAPHIGSLKTKIPH----IAVGSQTAQALRQQGFANIHAPQNGNDSEAALALPIWH 117 Query: 123 NI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + G +I+RG GGRE + TL RG V + ECYQR + +QA + Sbjct: 118 TLPQGGTIVIIRGQGGREHLAQTLHQRGFAVQYAECYQRIPQPLN----WQTFQAAQAQA 173 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 VTS ++ Q+L++ PQ + ++ L R+A+ LG + + Sbjct: 174 AWVTSSQLAQELFTQCPQAFTQN-LKSLLYFTQHMRIAQTLTALGASHVHTVARLSDA 230 >UniRef50_B4S2W7 Uroporphyrinogen-III synthetase n=2 Tax=Alteromonas macleodii RepID=B4S2W7_ALTMD Length = 243 Score = 143 bits (360), Expect = 6e-33, Method: Composition-based stats. Identities = 60/245 (24%), Positives = 96/245 (39%), Gaps = 15/245 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L TRP P + G A + P A + + +++ S + Sbjct: 2 LLFTRPLPKLKASALAFENAGIDAVGVATSDIVPVLSEQYAAAEFLSHNAINVIIVTSVY 61 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALH----TVSGQKILYPQDREISEVLLQL 118 AV S L + P A+G TA L +S I P+ SE +L + Sbjct: 62 AVDTVVSGLKKTA---AAPPLVVAVGDATAHKLRAGLSELSSVNIAIPK-VHTSEGILAM 117 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 +L ++ +I++G GGR+ I + L +G V Y+R + RW+ E Sbjct: 118 HQLNEANCQQVVIIKGEGGRDAIANGLDEKGMSVNSFCVYKREPLTRPIYT--KRWKLGE 175 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V+ ++ TS M QL LL L VS R+AK G +++ V A + Sbjct: 176 VSGIIATSEAMALQLIEQFGNA-----LLAYPWLTVSSRIAKTLTNKGIEEVAVCQRATD 230 Query: 239 DALLR 243 AL+ Sbjct: 231 QALIA 235 >UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verrucomicrobia RepID=B1ZV86_OPITP Length = 270 Score = 143 bits (360), Expect = 6e-33, Method: Composition-based stats. Identities = 50/247 (20%), Positives = 92/247 (37%), Gaps = 4/247 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR EL ++L LG PLI S LAD L LG D + S Sbjct: 14 RIIVTRAREQASELSAKLTALGAEVLELPLIRVSKHISKEALADVLLELGSYDWIVFTSA 73 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL-QL 118 + V + + + D + L + +G TA + + + P+ E L L Sbjct: 74 NGVRYFFEEFLRIFDDIRSLGLLRFACVGDATAKGIRELHLKVECQPK-VATGEALADAL 132 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 E ++ + +++ GN R+++ L A V + YQ + A ++ + Sbjct: 133 IETGSLDNAKVVVITGNLNRDVLVTKLEGAHAIVDQLQVYQTERVDLTDNPAAAEFRTQG 192 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V+ S + + + + ++ + G + VA + Sbjct: 193 ADAVLFASSSAVDSFAAQQAALTLQKGAKPPLFGSIGPLTSESLTKAGLEIGFVAKEPNL 252 Query: 239 DALLRAL 245 D+L++AL Sbjct: 253 DSLVQAL 259 Score = 44.8 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 29/124 (23%), Positives = 45/124 (36%), Gaps = 3/124 (2%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMV 182 + G+R ++ R + LTA GAEV R + H A + Sbjct: 10 LHGRRIIVTRAREQASELSAKLTALGAEVLELPL-IRVSKHISKEALADVLLELGSYDWI 68 Query: 183 VVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ + + + + L R V + AK REL + A +AL Sbjct: 69 VFTSANGVRYFFEEFLRIFDDIRSLGLLRFACVGDATAKGIRELHLKVECQPKVATGEAL 128 Query: 242 LRAL 245 AL Sbjct: 129 ADAL 132 >UniRef50_A3ETN4 Uroporphyrin-III C-methyltransferase / synthase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN4_9BACT Length = 516 Score = 142 bits (359), Expect = 9e-33, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 100/252 (39%), Gaps = 11/252 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLAALGESDLLFAL 59 IL+TR +G L L LG P IE P + ++ L L E + L L Sbjct: 263 RILLTREKESGSPLKDELEKLGAEVVSCPTIEIRPVTGMEREEVVRTLQNLSEYEWLLFL 322 Query: 60 SQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S + V + + + + L F++G +T L P + + +L+ Sbjct: 323 SPNGVRYFFRAMRETGKDIRSLSGCRIFSMGPSTTRTLEEYGIHPDATPLESY-ANGVLE 381 Query: 118 LPELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCA--IHYDGAEEAMR 173 Q +G+R L++RG+ G I D L A G ++ Y+ R +Y + Sbjct: 382 FFRSQIPCSGQRCLLIRGDRGDGAIPDGLAAMGFKIQQITAYENRIPELPNYLRDLVSGG 441 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 ++ ++ + V S + L SL+ + + + L + A R+ G +I + Sbjct: 442 FENQDFHLAVFYSPSAYKNLVSLLKEHGQS--IRKTTGLAIGPTTADALRKDGVTNILLP 499 Query: 234 DNADNDALLRAL 245 ++A+L + Sbjct: 500 SEPTDEAVLTTI 511 Score = 40.6 bits (94), Expect = 0.054, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 38/106 (35%), Gaps = 3/106 (2%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDGAEEAMRWQA-REVTMVV 183 GKR L+ R + D L GAEV C + R + E Q E ++ Sbjct: 261 GKRILLTREKESGSPLKDELEKLGAEVVSCPTIEIRPVTGMEREEVVRTLQNLSEYEWLL 320 Query: 184 VTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQ 228 S ++ + + + ++ L CR+ + + E G Sbjct: 321 FLSPNGVRYFFRAMRETGKDIRSLSGCRIFSMGPSTTRTLEEYGIH 366 >UniRef50_C1PAG5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacillus coagulans 36D1 RepID=C1PAG5_BACCO Length = 262 Score = 140 bits (354), Expect = 3e-32, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 84/245 (34%), Gaps = 3/245 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL+TR GE+L +++ LG + P++ F L + L L D + S+ Sbjct: 11 NILITRGGKDGEKLAAQIEALGGTPFVVPMVSFRAYADL-SASVFLRKLSAYDWVVFTSK 69 Query: 62 HAVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V + + L ++ A+G+ TA + + P+ ++ + Sbjct: 70 NGVRYFLEACSRAGIACEHLNINWAAVGKKTAACMEQSGLKVSFAPRK-FTAKDFAREFL 128 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 R L+ +GN I D L G Y+ + + Sbjct: 129 RSGHRASRVLLPKGNLAGTEIADFLRKSGIIAEEWIVYETYMPEGAKEKLTRLLGREHID 188 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + S + + + + L R+ V+ + + G + D +A Sbjct: 189 FALFLSPSAFRHFKGALEESGMDIAGLSTRIAVIGPSTRQAVEKAGSRAAVCPDEYTVEA 248 Query: 241 LLRAL 245 +L AL Sbjct: 249 MLGAL 253 >UniRef50_Q0EX10 Putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EX10_9PROT Length = 263 Score = 140 bits (354), Expect = 3e-32, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 89/248 (35%), Gaps = 10/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR + L +R G V FP + + +A L + S Sbjct: 10 RILLTRAAAQLPALAEMVRRRGAVPVAFPCLAVESMPDT--IMQAIAKLERFSDVLFTSC 67 Query: 62 HAVAFAQSQLHQQD---RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V+ L A+G TA L+ + + P+ S+ L Sbjct: 68 NGVSSVVDALGSHGMDAAALFAPMRVAAVGNQTADCLNQHGIRTDIVPET--ASQDGLVD 125 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 LQ+ +R L R GRE + + LT RG EV Y+ H D ++ + E Sbjct: 126 AYLQSGLPERLLFFRAEEGREALAEALTERGIEVETVAAYRTICPHDDASDVIAMLRDGE 185 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V V++ S + + + +S+++A A G VA +A Sbjct: 186 VDAVLLGSARACLHYLQRVGDATLAARPVS---VAISQKMAAAAMCGGLHVQLVAKSASF 242 Query: 239 DALLRALQ 246 +A+L L Sbjct: 243 EAMLDVLS 250 Score = 42.9 bits (100), Expect = 0.010, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 43/125 (34%), Gaps = 4/125 (3%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q +AG+R L+ R + + + RGA C D +A+ R Sbjct: 4 QPLAGRRILLTRAAAQLPALAEMVRRRGAVPVAFPC-LAVESMPDTIMQAIAKLERFSD- 61 Query: 182 VVVTSGEMLQQLWSLIPQWY--REHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+ TS + + + R+ V + A + G + V + A D Sbjct: 62 VLFTSCNGVSSVVDALGSHGMDAAALFAPMRVAAVGNQTADCLNQHGIRTDIVPETASQD 121 Query: 240 ALLRA 244 L+ A Sbjct: 122 GLVDA 126 >UniRef50_A9KP84 Uroporphyrin-III C-methyltransferase n=4 Tax=Clostridiales RepID=A9KP84_CLOPH Length = 502 Score = 139 bits (352), Expect = 6e-32, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 87/248 (35%), Gaps = 9/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTRP L +L++ G P I +P + L + L L + L S Sbjct: 255 KIVVTRPKELVSTLSEKLKSKGAEVLEIPTIRIAPLKNNIVLKNTLLQLDQFQWLVFTSP 314 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V + + ++ +L +G T + L P++ + L + Sbjct: 315 SGVDVFFNAMKEEKIDIRKLANLKVAVVGEGTKKKVEDRGILVDLIPENYY-GKSLGKSI 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARG-AEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + G R LI R + G E I + + EV Y D ++ Sbjct: 374 RMSCCDGDRILIPRASIGNEEIMEEIKKNPLLEVMDIPIYDTVYSTPDIINLKDEFERGN 433 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + V TS + ++ L++ + + E+ A++ + ++ A Sbjct: 434 IDFAVFTSKSTVTGFVK--ATKDLDYHLVNA--VCIGEQTRDEAQKNNMKT-WMSKKATI 488 Query: 239 DALLRALQ 246 D+L+ ++ Sbjct: 489 DSLVETIE 496 >UniRef50_Q4JSX6 Uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase n=5 Tax=Actinomycetales RepID=Q4JSX6_CORJK Length = 628 Score = 139 bits (351), Expect = 8e-32, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 90/252 (35%), Gaps = 13/252 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R + +RL + G + P I P + Q+ + L G + Sbjct: 348 TVLVPRAKNQAGPMSTRLASHGAIPVEVPTISVEPPRSPVQMERAIKGLVDGRYHWIVFT 407 Query: 60 SQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQD-REISEVLL 116 S +AV +L + L A+G T+ A+ + L P+D + L+ Sbjct: 408 SVNAVKAVWEKLREFGLDARALAGVRVAAVGPKTSQAVKDLGITPELLPKDDARNAAGLV 467 Query: 117 QLPELQNIA---GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 ++ + R L+ R + +++ D L G +V Y+ E Sbjct: 468 EVFPPHDPDLDLVDRVLLPRADIATDVLVDGLIELGWDVEDVVAYRTVRAAPPSPEIRDM 527 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V TS ++ L + + + + + A+ ARE G + + Sbjct: 528 IKTGGFDAVCFTSSSTVKNLVGIAGKPHA-----RTIIACIGPMAAQTAREHGLRVDVMP 582 Query: 234 DNADNDALLRAL 245 + A L+ AL Sbjct: 583 EAAGVPELVDAL 594 >UniRef50_Q2NF31 HemD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NF31_METST Length = 259 Score = 139 bits (350), Expect = 9e-32, Method: Composition-based stats. Identities = 50/253 (19%), Positives = 83/253 (32%), Gaps = 16/253 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TRP + L + G P +E + +L + + D + S Sbjct: 10 NVVITRPIERSQTLSDMILKKGGKPIIVPTLELQ-LVESKELVYIIENIETFDWIVFTSP 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V L + D IG T L + L P+D +E LL+ + Sbjct: 69 AGVKSFFK-LCKLDIIPS---KIAVIGVKTEEELLKYGFKPDLIPKD-FTAEGLLESFKS 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMRWQAREV 179 N+ K + R RE++ L GA V E Y H E V Sbjct: 124 INLKNKNVALPRTLSAREVLPKGLEDYGASVLIAEAYTSGIPHDTTKIIELCNDIIDGLV 183 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREH-----WLLHCRLLVVS--ERLAKLARELGWQDIKV 232 ++ TS ++ L + L R++V S AK E G I+ Sbjct: 184 DIITFTSPLTVKNLMEVYKNSQPSRLDELILALKSRVVVASIGPITAKSLSEYGICTIE- 242 Query: 233 ADNADNDALLRAL 245 ++ A+ Sbjct: 243 PSRYTVKDMVEAI 255 >UniRef50_B4SRW6 Uroporphyrinogen III synthase HEM4 n=4 Tax=Xanthomonadaceae RepID=B4SRW6_STRM5 Length = 269 Score = 138 bits (349), Expect = 1e-31, Method: Composition-based stats. Identities = 62/242 (25%), Positives = 95/242 (39%), Gaps = 13/242 (5%) Query: 7 RPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ----QLPQLADQLAALGESDLLFALSQH 62 RP L + L L+ SP + + QL D + S Sbjct: 26 RPQGQHAALRRAVAGLDGH-----LLALSPWRLQRLHGTPVVRQLQRALNCDRVVFTSP- 79 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A + + + +G TA AL ++ PQ R SE LL LP L Sbjct: 80 --AAVAAAASLLPLADAQRSPWLTVGEGTARALRAQGVHEVHAPQ-RMDSEGLLALPVLA 136 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R ++ GGR LI L A GA + + YQR + A + ++ Sbjct: 137 DVRGRRIGLVTAPGGRGLIAAQLQAAGASIERADVYQRRPLRLSPRTLARLAHSAYPWVL 196 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 V+SGE LQ W +P ++ H ++V S+RL + A+ LG Q I + L+ Sbjct: 197 AVSSGEALQHFWRQLPHALQQRLQAHASVVVASDRLREQAQALGLQRISRSAGPAGAQLV 256 Query: 243 RA 244 A Sbjct: 257 SA 258 >UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea blandensis MED297 RepID=A4BAP9_9GAMM Length = 246 Score = 138 bits (349), Expect = 1e-31, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 93/254 (36%), Gaps = 24/254 (9%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSP--GQQLPQLADQLAALGESDL---L 56 IL+ + S L + P LPQ A+ DL + Sbjct: 3 RILIPKASREQARWQQALAGESIEP-----LWIDPWQMSGLPQTAEHRNQWLNLDLFSGV 57 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +S A + L + P + G TA L + PQ +E +L Sbjct: 58 VCVSPTAAEVLVAALDEFWPMPPSGVHWLCNGPRTAEVLSEAGLTPVF-PQQGHTAEQVL 116 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LPE Q G + LI++G GGR + TLT RGA T Y+R A+ D + +A Sbjct: 117 ALPEAQCAQGDKWLIVKGEGGRVTLAQTLTERGAIATELPVYRR-AVDNDALQYMTSIRA 175 Query: 177 REVTMVVVTS----GEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 + ++S +L Q L W E W V S RL + G + ++V Sbjct: 176 DA-DALWLSSEFLGESLLNQGRDLWQSWTGEWW-------VSSPRLKDWCQAQGCRRVRV 227 Query: 233 ADNADNDALLRALQ 246 A A AL ++ Sbjct: 228 ASGATVQALQAMIR 241 >UniRef50_O26268 Putative uroporphyrinogen-III synthase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM4_METTH Length = 253 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 82/245 (33%), Gaps = 7/245 (2%) Query: 5 VTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAV 64 VTRP E V + G A P +E L + E DL+ SQ AV Sbjct: 3 VTRPPERSAEAVELIEGAGGRALVAPTLELK-EAHTESLREVCRRADEWDLVIFTSQAAV 61 Query: 65 AFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNI 124 + K + IG TA + + P+D +E LL NI Sbjct: 62 ESLFQLCREFAGKIRKDCLVAVIGPRTARVAGEHGLRVDIVPED-YTAEGLLDALTGLNI 120 Query: 125 AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY--DGAEEAMRWQAREVTMV 182 G + + R R+++ L GAEV E Y+ E +V V Sbjct: 121 EGWKVALPRTLSARKVLPRGLEMMGAEVLVAEAYRSGLPEDTGPAEELIDGLLDGKVDAV 180 Query: 183 VVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 TS ++ L+ + +E L ++ + + E G + + Sbjct: 181 TFTSPLTVENLFKIAGNRRKELIEVLKRVKVAAIGPITLRKLEEHGITAVT-PERYTVKD 239 Query: 241 LLRAL 245 ++ AL Sbjct: 240 MIAAL 244 >UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chloroflexus RepID=B8G819_CHLAD Length = 254 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 101/247 (40%), Gaps = 16/247 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALG--ESDLLFAL 59 I +TRP+ G+ L +RLR LG + PLI ++P L LA L D L Sbjct: 8 RIAITRPAGRGDTLAARLRALGAIPLLTPLIAYAPPADPAPLQHALAQLAAGTYDWLVVT 67 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S+ AV P A+G+ TA G++ D E+ L Sbjct: 68 SRQAVQVLAEA------TVPTTTAIAAVGKATAADCRRTWGREPAGVPDEELGAALPN-- 119 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + GKR L+ + + L A GA V Y+ + AE A ++ + Sbjct: 120 VMGTLTGKRILLPCADIAPSTLTAALQAAGAIVDRVTAYRTIS-SPAAAELAAALRSGTI 178 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V+ SG +Q+ +L+P + L+ + A + ELG +A ++D Sbjct: 179 DAIVLASGSAARQIPALLPPQTQCP-----PLVCIGPSTAAVCTELGLPVAAIAIRPNDD 233 Query: 240 ALLRALQ 246 ALL AL+ Sbjct: 234 ALLAALE 240 >UniRef50_Q8EPM9 Uroporphyrinogen-III synthase n=1 Tax=Oceanobacillus iheyensis RepID=Q8EPM9_OCEIH Length = 252 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 81/244 (33%), Gaps = 10/244 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 S+L+TR E ++ G PL+ + L + + + S Sbjct: 9 SVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNP--IWLHLKKYEWILFTSS 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V LHQ D ++P +G T LAL + P +E + + Sbjct: 67 NGVHGFFHFLHQLDIEFPSDIKVGIVGTKTKLALDEYELKPDFIPSI-FDAETMAKEFIE 125 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + LI+RGN R +I + T E Y+ + E + V Sbjct: 126 SYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEVYETTYRYEAKRELEDTIK--NVDF 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V +TS + L L+ C + + A +L ++ + DA+ Sbjct: 184 VTLTSPSTVTALMKLVKDIP-----FSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAM 238 Query: 242 LRAL 245 + + Sbjct: 239 IEVM 242 >UniRef50_A7NKU9 Uroporphyrinogen III synthase HEM4 n=2 Tax=Roseiflexus RepID=A7NKU9_ROSCS Length = 269 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 58/249 (23%), Positives = 96/249 (38%), Gaps = 12/249 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I VTR + E L + L + G P I ++P +L L L + D + S Sbjct: 11 RIAVTRAAERAEGLAAALSSEGAEVLVCPTIAYAPPDDPDRLEAALERLDQYDWIIFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV + Q P A+G+ TA A+ + G+ L P + +E LL EL Sbjct: 71 AAVD---TLARYQALPPPLHVRVAAVGKATAAAIESRGGRVDLLPAQQ-NAEGLLA--EL 124 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +N+AG+R L+ + R+ + L R A V Y+ + R + Sbjct: 125 RNVAGQRFLLPVSDIARDTLAVGLREREALVDVVTAYRTV-PGPGVRDLIDPLCRRAIDA 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCR-----LLVVSERLAKLARELGWQDIKVADNA 236 VV +S L+ L + Q+ + L+ + A+ R+ G A N Sbjct: 184 VVFSSPSTLRYLIDGMEQFGIARSVARALFDGVALIAIGPTTAQALRDEGLSVAAQAPNP 243 Query: 237 DNDALLRAL 245 + + A+ Sbjct: 244 AVEGVAEAV 252 >UniRef50_Q31D67 Uroporphyrinogen-III synthase n=7 Tax=Prochlorococcus marinus RepID=Q31D67_PROM9 Length = 265 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 86/248 (34%), Gaps = 9/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I++TR ++ + G + FP I L L + L + + + S Sbjct: 12 NIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQINDFHWIIFSSS 71 Query: 62 HAVAFAQSQLHQQDRKW---PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + + F +L + +G TA L + P + ++ Sbjct: 72 NGIKFVDKRLRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPEYVAESLIDNF 131 Query: 119 PELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P G R + R GGR+LI D G+ V Y+ E R Sbjct: 132 PISG--YGLRVFLPRVQTGGRDLIADQFRKAGSRVFEVAAYETRCPDSIPEETIDIIVNR 189 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLL---HCRLLVVSERLAKLARELGWQDIKVAD 234 +V + +SG+ + L+ + + + WL R L + + K+ +++ + A Sbjct: 190 KVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKIFGRVDSQAQ 249 Query: 235 NADNDALL 242 D LL Sbjct: 250 KYTFDGLL 257 >UniRef50_P21248 Uroporphyrinogen-III synthase n=4 Tax=Bacillus RepID=HEM4_BACSU Length = 262 Score = 138 bits (347), Expect = 2e-31, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 73/244 (29%), Gaps = 2/244 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR ++ LG A LI F L L S Sbjct: 11 TVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + F S L + P A+G TA L + + PQ+ I+E L + Sbjct: 71 NGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQE-YIAEQLADALKQ 129 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ +++GN R++I L G EV Y+ Sbjct: 130 HAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKDAAGQYSFDY 189 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS + ++ + ++ + + G D D + Sbjct: 190 VTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHT-PDTFTIDGM 248 Query: 242 LRAL 245 L + Sbjct: 249 LELM 252 >UniRef50_B0TXX7 Uroporphyrinogen-III synthase n=18 Tax=Francisella RepID=B0TXX7_FRAP2 Length = 252 Score = 137 bits (346), Expect = 3e-31, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 105/252 (41%), Gaps = 25/252 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ILV RP ++L LR+ G A P I ++A + S Sbjct: 1 MKILVCRPKDDADKLSQLLRSKGYTATSLPCINI----DYIRIASSVLGYTSY---IFTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV S Q + + +++G++TA L +YP D S+ LL+L Sbjct: 54 KYAVE---SLFAQYNPELFHDKKLYSVGQSTAKTLKKYG-LDAIYPHDHG-SQELLKLIL 108 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC---ECYQRCAIHYDGAEEA-MRWQA 176 ++++ ++ G G EL L +++T C E YQR +A +++ Sbjct: 109 EEDVSDDSFAVISGVSGNEL----LVKEISQLTKCDKFETYQRVFESVAALSQAYLKFID 164 Query: 177 REV--TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + ++V TS ++ + L + + + + + S ++ K E G+++ + Sbjct: 165 DGINPDVIVTTSIDIFKSLNRIFGEIVAPRAAI---VTITSPKMLKFVNEQGFENTLKLE 221 Query: 235 NADNDALLRALQ 246 DN+ + + ++ Sbjct: 222 KLDNNCIYQKIR 233 >UniRef50_B5YJZ5 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJZ5_THEYD Length = 509 Score = 137 bits (346), Expect = 3e-31, Method: Composition-based stats. Identities = 49/255 (19%), Positives = 94/255 (36%), Gaps = 19/255 (7%) Query: 2 SILVTRPSPAGEELVS---RLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 +L+TR +L L +G + FP I F+P + +L + + E + Sbjct: 256 RVLITR------QLTEDYLLLEDMGAELFVFPTIAFAPPEDFKELDRAIEKIKEYKFIVF 309 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYF--AIGRTTALALHTVSGQKILYPQDREISEVLL 116 S AV F + R L AIGR TA +L + P D SE L+ Sbjct: 310 PSPRAVNFFFERFLSLGRDMRDLKGVLLCAIGRETAKSLRNFGINADIIP-DEYSSEALI 368 Query: 117 QLPELQNIAGK------RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE 170 + + + + + + L R + + + + G +V Y+ G Sbjct: 369 TMFKEKILNFQPSAFSLKILYPRSDLALKGFVEEMEKIGIQVDAPVTYRTIKPTEHGKRL 428 Query: 171 AMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 A + ++T+ TS L ++ + L + V+ + AK E G++ Sbjct: 429 ARFLREGKITIATFTSPSSFNNLIDILKD-DALNMLKEVAIAVIGKTTAKAVEEAGYRVS 487 Query: 231 KVADNADNDALLRAL 245 + + + ++ A+ Sbjct: 488 IIPEKSTIKHMVEAI 502 >UniRef50_C1ZIN7 Uroporphyrin-III C-methyltransferase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZIN7_PLALI Length = 563 Score = 136 bits (343), Expect = 7e-31, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 10/253 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + I + RP GE LG P I S + + + E D + S Sbjct: 284 LRIAIPRPLEQGELTALECEQLGGSPLLMPTISISSIDDWTLVDGIIDRIAEFDWIIFTS 343 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V L Q+ L IG +TA L + P EVL + Sbjct: 344 VNGVRCFMQHLWQRGLDGRELAGCRLAVIGASTAAELEKWHLRADFVPSQ-FRGEVLAEE 402 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 Q AG+ R N GRE+I + L G + Y+ + A+ + +E Sbjct: 403 LAQQFSAGRAIW-FRANRGREVIPERLQKAGWSMETAVVYRNEDVTSWPADFWEKLSRKE 461 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREH------WLLHCRLLVVSERLAKLARELGWQDIKV 232 V + ++S M + L+ + RE ++ R + +S + A E G Sbjct: 462 VDWIALSSPSMARNWKKLLDAYLRESGRNASEFINAARFVSISPVTTQAALEAGLSISAE 521 Query: 233 ADNADNDALLRAL 245 A + + RA+ Sbjct: 522 ASVFTWEGIFRAI 534 >UniRef50_C8NSF6 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=58 Tax=Actinomycetales RepID=C8NSF6_COREF Length = 626 Score = 135 bits (340), Expect = 1e-30, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 93/253 (36%), Gaps = 15/253 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R P + +RL + G + P I P + Q+ + + G + Sbjct: 354 RVLVPRAKPQAAAMSARLASHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLT 413 Query: 60 SQHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLL 116 S +AV + + A+G TA + + L P +R+ ++ ++ Sbjct: 414 SVNAVRAVWDMITEFGLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPPRNRQNAQGIV 473 Query: 117 QL----PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM 172 + E + G R L+ R + +++ D L A G EV Y+ A+ Sbjct: 474 DVFPEYIEELDPVG-RVLLPRADIATDVLVDGLVALGWEVDDVVAYRTVRAAPPSADIRD 532 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 + V TS ++ L + + + + + A ARELG + + Sbjct: 533 MIKTGGFDAVCFTSSSTVRNLVGIAGKPHP-----RTIIACIGPMTADTARELGLRVDVM 587 Query: 233 ADNADNDALLRAL 245 + A+ L+ AL Sbjct: 588 PEIAEVPDLVDAL 600 >UniRef50_C0DSC1 Putative uncharacterized protein n=1 Tax=Eikenella corrodens ATCC 23834 RepID=C0DSC1_EIKCO Length = 251 Score = 134 bits (339), Expect = 2e-30, Method: Composition-based stats. Identities = 64/244 (26%), Positives = 99/244 (40%), Gaps = 11/244 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+ RP+ + R G FPLI P LA L ++ +S Sbjct: 7 LLIIRPANRIPADAALCRRTGWQPVPFPLIHIRPEAN--ALAGLPTQLQQASAAVWISPT 64 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV A S L P A+G TA AL +I+ P + SE +L LP Q Sbjct: 65 AVETALSLLSGSLISSLSQPQI-AVGSGTAKALQQAGFARIVAPDNGHDSEAVLALPLWQ 123 Query: 123 NI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + G +I+RG GR + DTL RG +V + YQR + D + A + Sbjct: 124 RLNPGASVVIIRGREGRNTLPDTLYRRGFQVACADIYQRQPLMPD----WTLFTAAQPAA 179 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD--ND 239 +TS E ++ L++ P + L R+A+ + G I++ +A + Sbjct: 180 AWITSAEQVRLLFAAAPASLTQQ-LQSLLYFAHHPRIAEALSQAGAARIRLLSSAAELEN 238 Query: 240 ALLR 243 AL+ Sbjct: 239 ALIA 242 >UniRef50_A6CN70 HemD n=1 Tax=Bacillus sp. SG-1 RepID=A6CN70_9BACI Length = 266 Score = 133 bits (336), Expect = 4e-30, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 89/245 (36%), Gaps = 11/245 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTR A + + ++ G + PLI F P + + + L L D +F S++ Sbjct: 12 ILVTREEKAAKGIADVIKQYGGIPHIVPLISFRPYEDEKE-STYLEKLKSYDWIFFTSKN 70 Query: 63 AVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDR----EISEVLLQ 117 V F +L + + P + A+G T A+ + Q P+ E + Sbjct: 71 GVHFFFQKLKEHNLSIVGSPTKFAAVGEKTCRAMKSHGIQVDFVPKLYSGFDFAKEFVHS 130 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P+ R L+ +GN ++ I T R + Y+ + Q + Sbjct: 131 FPQAG-----RVLLSKGNLAKDTISSYFTERSMPIDEWITYETFFPDAIEKRLSSLLQEK 185 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 +++ V TS ++ ++ + ++ + + A G V + Sbjct: 186 KLSAVTFTSPSTVRGFMKIVNDNGLHEAMNGLAVVCIGPVTREAACRYGLTVQVVPERYT 245 Query: 238 NDALL 242 + ++ Sbjct: 246 VEDMI 250 >UniRef50_C7P5B9 Uroporphyrinogen III synthase HEM4 n=1 Tax=Methanocaldococcus fervens AG86 RepID=C7P5B9_METFA Length = 243 Score = 132 bits (333), Expect = 8e-30, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 86/248 (34%), Gaps = 15/248 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + L+ G FP +E + + L D + S Sbjct: 1 MKVVITRPKERADVFSKLLKKEGFEPIIFPTLELIYNKDIKV------NLDNYDWIVFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + + + R+ + IG TA A G+++ +E LL+ + Sbjct: 55 PSGVIGLYNIIEEAQREEVKNKKIAVIGEKTAKAFKEYFGREVDVMPKEYTAESLLEEIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA--RE 178 + + LI R+++ + L A Y+ + E Sbjct: 115 KTAKSDDKFLIPTTPSTRDVLKNNLNA-----DLLFVYKSVEPENLKENIEKLKENIKDE 169 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ TSG + + + + E + + ++ + AK+ E G++ + Sbjct: 170 RFILTFTSGLTAKNFFKYVDDEFAEI-IKNNYIVAIGPITAKVIEEFGFK-PLIPKIYTI 227 Query: 239 DALLRALQ 246 + +L ++ Sbjct: 228 EGILEVIK 235 >UniRef50_Q5WEP6 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus clausii KSM-K16 RepID=Q5WEP6_BACSK Length = 252 Score = 132 bits (333), Expect = 1e-29, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 82/245 (33%), Gaps = 12/245 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 IL+TR E + L LG + PLI+ P L + A L + + S + Sbjct: 9 ILITRDERQNERWAAELAVLGAIPHSLPLIQCVTRNLTPALRETFAHLHQFAWVVFTSAN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V Q P + A+G TA L P + E L + Sbjct: 69 GVRAFFDLYKGQ----PFMAKVAAVGPKTAQLLEEQGLHCDFIPSE-YTGEALAKELVPL 123 Query: 123 NIAGKRALILRGNGGRELIGDTLTA--RGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L+++G + + D L++ R A VT Y E+A R Q + Sbjct: 124 LAPHSDVLVVKGQLAKRTVCDILSSSDRQATVTEMIVYDTLCPAG-AEEQAKRLQQKTFD 182 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V +TS ++ P + + + A+ A++ G + A Sbjct: 183 YVTLTSTSAAVHYANVAPAAG----IRAKTIACIGPVTARAAKQCGLSPLVTASEYTVKG 238 Query: 241 LLRAL 245 L+ + Sbjct: 239 LIDTI 243 Score = 48.3 bits (114), Expect = 2e-04, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 39/125 (31%), Gaps = 5/125 (4%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ + GK LI R E L GA Q + A + Sbjct: 1 MKPLKGKHILITRDERQNERWAAELAVLGAIPHSLPLIQCVTRNLTPALRETFAHLHQFA 60 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV TS ++ + L ++ V + A+L E G + +A Sbjct: 61 WVVFTSANGVRAFFDLYKGQP-----FMAKVAAVGPKTAQLLEEQGLHCDFIPSEYTGEA 115 Query: 241 LLRAL 245 L + L Sbjct: 116 LAKEL 120 >UniRef50_A6GI22 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GI22_9DELT Length = 512 Score = 132 bits (332), Expect = 1e-29, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 89/259 (34%), Gaps = 15/259 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLA--ALGESDLLF 57 ++VTR + L+ L G A FP +E + + + L LA L + + Sbjct: 249 RVVVTRAARQSGGLLHALAGAGADAVAFPCLEVAAPEPAEREALDAALAPDRLAGLEGVI 308 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVL 115 S + L + + AIG TA + L P SE L Sbjct: 309 VSSPNGADALFDALARLNLDARAFAGKLLAAIGTGTAARCQAKGLRPDLIPAKAR-SEGL 367 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE----A 171 ++L + + G R L +R + GR+L+ + ++ G + Y+ G Sbjct: 368 IELLRARGLLGGRWLHVRADQGRKLLAEAISEAGGSIELVIGYRTVRPEVPGLLLDSLRP 427 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH----WLLHCRLLVVSERLAKLARELGW 227 + + SG + + + +L +++ + A L Sbjct: 428 VADGGEGYDAICFASGRTARHFLETTGERFGADAARGFLEQAKIVAIGPVTADALAALDL 487 Query: 228 QDIKVADNADNDALLRALQ 246 + VAD + ++ A++ Sbjct: 488 RVDAVADTPSDAGMVEAVK 506 >UniRef50_A7Z7A4 HemD n=1 Tax=Bacillus amyloliquefaciens FZB42 RepID=A7Z7A4_BACA2 Length = 259 Score = 131 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 73/244 (29%), Gaps = 2/244 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR ++ LG A LI F L E L S Sbjct: 11 TVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLSEPGWLVFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F S L + A+G TA AL + P D ++E L + Sbjct: 71 NGVRFFFSYLDRHGLALSGRKKIAAVGEKTARALKERGARTDAMP-DEYVAECLADTLKR 129 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 A + +++GN R++I L G ++ Y E Sbjct: 130 YASAAEPISVIKGNLSRDVIKAELEPLGYQIREWVLYNTIQDEKGMDELRRAASRSHFDF 189 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS + + + + + K E G V D + + Sbjct: 190 ITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSH-VPDTYTIEGM 248 Query: 242 LRAL 245 L + Sbjct: 249 LDVM 252 >UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonadaceae RepID=A1VRW0_POLNA Length = 287 Score = 131 bits (329), Expect = 2e-29, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 93/269 (34%), Gaps = 36/269 (13%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPG---QQLPQLADQLAALGESDLLFA 58 ++VTRP+P V +L G A F LI+ +P L D AL Sbjct: 5 RVIVTRPAPDAALWVRQLEQAGIAAEAFELIDIAPVGSAADAQALGDAWLALDAYAACLF 64 Query: 59 LSQHAVAFAQSQLHQQD-----------------RKWPRLPDYFAIGRTTALALHTVSGQ 101 +S HAV + R+ P + A G T AL Sbjct: 65 VSGHAVEHFFKENKAFAQGGYAQAAINNIANSGLRRIPPGLRFMAPGPGTVAALRAAGVP 124 Query: 102 KI-----LYPQDREISEVLLQLPELQNIAGKRALILRGN--------GGRELIGDTLTAR 148 + SE L ++ ++ G++ LI+RG GR+ I Sbjct: 125 AAQIDAPAADASQFDSEALWRVVGARDWQGRKVLIVRGQSAGAQGATSGRDWIVRQWQGA 184 Query: 149 GAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHWLL 207 GA V F YQR A A+ A QA + ++ + +S E + L + Sbjct: 185 GASVDFVGVYQRRAPILTDAQVARARQASADGSVWLFSSSEAVANLVGQAGLQGVDWG-- 242 Query: 208 HCRLLVVSERLAKLARELGWQDIKVADNA 236 R + R+A+ R GW + + A Sbjct: 243 RARAVATHPRIAQAVRAAGWGVVVESRPA 271 >UniRef50_D1YA62 Uroporphyrinogen-III synthase n=2 Tax=Propionibacterium acnes RepID=D1YA62_PROAC Length = 571 Score = 130 bits (328), Expect = 3e-29, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 81/243 (33%), Gaps = 12/243 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +IL+ R L SRL++ G + P I P + Q+ + L G + + Sbjct: 293 NILIPRTRDHSATLPSRLQSYGAHSLDVPTISMEPPRTPQQMDKAIRGLVEGRYEWVVFT 352 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV +L Q AI +T AL + P + + L Sbjct: 353 SANAVRAVSEKLEQIGLDARAYSGLRIAAIFDSTINALAEWGVRPDFVPSGEQSTRALAA 412 Query: 118 -LPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 P R + R + E + L+ G EV Y+ AE Sbjct: 413 VFPAFDEALDPINRVFVPRADIATESLSADLSELGWEVEDVVGYRTVRAAPPPAETREAI 472 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + + VV TS ++ L + + + H + V R A+ RE G +A Sbjct: 473 KTGKFDAVVFTSSTTVRNLVGIAGKPH-----KHTVVAAVGIRTAETCREHGLTVDVIAP 527 Query: 235 NAD 237 Sbjct: 528 EPT 530 >UniRef50_Q59335 Uroporphyrinogen-III synthase n=11 Tax=Chlorobiaceae RepID=HEM4_CHLP8 Length = 246 Score = 130 bits (327), Expect = 4e-29, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 80/248 (32%), Gaps = 13/248 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP V L G FP IE P + L + +F S Sbjct: 3 TVLVTRPKHQAAPFVRELEQYGLSTVVFPTIEIRPVAGWN-----VPDLTKFAGIFFTSP 57 Query: 62 HAVAFAQSQLHQQDRKW---PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 ++V F L Q + +A+G+TT L P+ + L+ Sbjct: 58 NSVQFFLKHLLQTAPDELKNLQQTRVWAVGKTTGQDLEKHGVSIEPLPKIA-DAVNLMAD 116 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEAMRWQAR 177 + I G+ L +RG+ I + + G Y+ D Sbjct: 117 IDPAEIKGQTFLFVRGSLSLGTIPELIAEFGGTCVELTVYENLPPSLEDTQRVKDMLAEG 176 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++ + TS + + I ++ + + ++G + + + D Sbjct: 177 KLDCLSFTSPSTAKNFFEAIGSKELSD---SVQIAAIGTTTSGALEKMGIKVDIIPEYFD 233 Query: 238 NDALLRAL 245 + +A+ Sbjct: 234 GPSFAKAI 241 >UniRef50_UPI000050FC32 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050FC32 Length = 530 Score = 128 bits (322), Expect = 2e-28, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 81/250 (32%), Gaps = 12/250 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFALS 60 +L+ R G L LG V P I P + Q+ + L G + + S Sbjct: 256 VLIPRTKEQGTSTAEALGELGAVGTVVPTIAVQPPRTPTQMEKAIRGLVDGSYEWVGFTS 315 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV + L A+G TA +L L P + L Sbjct: 316 VNAVRAVRMWFEDFGLDSRSLSGVKVAAVGGRTAASLIDWGITPDLVPDGEHSARGLAAA 375 Query: 119 --PELQNIAGK-RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 + +I L+ R + E++ L +G + Y+ A + Sbjct: 376 WPDYVDDIDPMNTVLLPRADIATEVLVAGLLEKGWDPDDVTAYRTVRASPPPAPIREAIK 435 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 A + + TS ++ L + + + + A A E G + +A+ Sbjct: 436 AGDFDAFLFTSSSTVRNLVGIAGKPASTS-----VICCIGPATANTAAEHGLRVDVLAEE 490 Query: 236 ADNDALLRAL 245 A+ +L+ L Sbjct: 491 ANLTSLIDGL 500 >UniRef50_C6HUG3 Uroporphyrin-III C-methyltransferase / synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG3_9BACT Length = 539 Score = 128 bits (322), Expect = 2e-28, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 82/248 (33%), Gaps = 8/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR +EL L LG FP I SP + + L + + LS Sbjct: 265 RILLTRERSRSKELSETLEALGATVITFPTIHVSPSFSEKSMH-TIEHLKDFAWIVFLSP 323 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + L + ++ L F++G T+ AL+ + L P + V+ Sbjct: 324 NGVQYFLEGLGKSNKDLRSLAGLRIFSMGPATSTALNEAGLRPDLAPAESHGEGVIDAFR 383 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG---AEEAMRWQA 176 L + L++RG+ G I L G V Y+ Sbjct: 384 NLPEPHSGKVLLVRGDRGTGAIPRGLEELGYGVETISVYENTLPDVPSYRMERLRTILDE 443 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + + + S ++ SL P + L + + Q + +A N Sbjct: 444 GAIDLAIFYSPSAIRGFISLFPDHAEA--ISRIPSLAIGPTTREELLRSAIQTLVMAKNP 501 Query: 237 DNDALLRA 244 +++ Sbjct: 502 TTPSVVET 509 >UniRef50_Q58401 Putative uroporphyrinogen-III synthase n=8 Tax=Methanococcales RepID=HEM4_METJA Length = 240 Score = 128 bits (321), Expect = 2e-28, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 88/248 (35%), Gaps = 15/248 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + S L+ G FP +E + L L D + S Sbjct: 1 MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDV------NLDSYDWIAFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + L + +R+ + IG TA G+ + +E LL+ + Sbjct: 55 PSGVIGLYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE--AMRWQARE 178 + ++ LI R+++ + L A Y+ + A++ Sbjct: 115 KVSKEEEKFLIPTTPSTRDVLKNNLNA-----DLLFVYKSAEPENLKEDIKKLKELIAKD 169 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ TSG + + + + E + ++ + AK+ + G++ + Sbjct: 170 KFILTFTSGLTAKNFFKYVDDEFAEI-IKDNYIVAIGPITAKVIEKFGFK-PLIPKVYTI 227 Query: 239 DALLRALQ 246 + +L ++ Sbjct: 228 EGMLEVIR 235 >UniRef50_C1AA39 Putative uroporphyrinogen-III synthase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA39_GEMAT Length = 259 Score = 127 bits (320), Expect = 3e-28, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 85/246 (34%), Gaps = 7/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I VTR G L LR +G PL P L L L D + S Sbjct: 9 RIAVTRTVERGGPLADALRRVGATVHEIPLTHIEPL-DAAPLHAALRELAHYDWVLLTSV 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAI-GRTTALALHTVSGQKILYPQDREISEVLLQ-LP 119 +AV + + + A+ G TTA A + + +R +E +L L Sbjct: 68 NAVERLAQAVREVGAESVMESRRLAVVGSTTAAACESHGWRLPTVQPERMQAEGVLDDLA 127 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ G R L G R+++ + L A GA V Y+ ++ EV Sbjct: 128 SRSDVEGSRVLYPAAAGARDVLPEGLRALGAVVDVIATYRTVPDAAGQERMLALVESGEV 187 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V + + + L +P + + A+ AR G+ + + Sbjct: 188 DLVTLAAPSAMDALLDALPPERA----SRLPVACIGPVTARAARLAGFPVKVESTAPTVE 243 Query: 240 ALLRAL 245 +R++ Sbjct: 244 GWVRSI 249 >UniRef50_UPI0001972E7B uroporphyrin-III C-methyltransferase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972E7B Length = 542 Score = 127 bits (320), Expect = 3e-28, Method: Composition-based stats. Identities = 47/267 (17%), Positives = 81/267 (30%), Gaps = 26/267 (9%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP + RLR G P E + L L L + S Sbjct: 271 KILVTRPKRRSAGMAGRLREAGAEVVELPAAEPRLLEDTSFLDRTLERLADFKWAVFTSP 330 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREI-------S 112 V L ++ D + + IG TA AL P++ + Sbjct: 331 SGVELFFEYLRREKKDIRLLMGLKFAVIGAGTAKALCRYGFYADYMPENFYAKELGRGLA 390 Query: 113 EVLLQLPELQNIAGK------------RALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 E +L + + G+ + L+LR + + L Y+ Sbjct: 391 ETILHEMKEEEKRGENGRGGAGCGKPVKVLLLRAQKASPALCEELARAEIPFEDAVLYRT 450 Query: 161 CAIHYD--GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERL 218 + + + V TS ++ L+ E L + + E Sbjct: 451 EFPAPSMQAERVKILLEKKAFDYVTFTSESTVKGFLELLSPTDEE--LCGFTAVCIGEMT 508 Query: 219 AKLARELGWQDIKVADNADNDALLRAL 245 K ARE G + + ++ D++ + Sbjct: 509 EKAAREAGMRTVT-SEVPSMDSMAECM 534 >UniRef50_UPI0001BC6E7F uroporphyrinogen-III synthase, putative n=1 Tax=Buchnera aphidicola str. LSR1 (Acyrthosiphon pisum) RepID=UPI0001BC6E7F Length = 137 Score = 127 bits (320), Expect = 3e-28, Method: Composition-based stats. Identities = 42/131 (32%), Positives = 76/131 (58%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 +++ I R ++L+G GR+LI L G ++ ECY+R D E +W+ Sbjct: 1 MKIINKDKIKNNRIILLQGENGRKLIKRRLEKEGFKICLIECYKRVFKILDTNMEVKKWR 60 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + ++ +VVT+ E L QL ++I + WL CR+ VV +RL ++A++LGW D+ V+ Sbjct: 61 SYKIDTLVVTNSESLHQLKNIISSTNQIQWLFGCRIFVVGKRLFRIAKKLGWNDVIVSKY 120 Query: 236 ADNDALLRALQ 246 A+ND+ ++ ++ Sbjct: 121 ANNDSFIKRIK 131 >UniRef50_UPI0001C42100 uroporphyrinogen-III synthase HemD n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42100 Length = 258 Score = 127 bits (319), Expect = 4e-28, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 77/247 (31%), Gaps = 9/247 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I +TRP + + G A P +E + L + + E D L S Sbjct: 4 KIAITRPQERSKAAKEFIENYGSEAIIVPTLELK-LENTESLKNLMEKSNELDWLIFTSV 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 ++ K IG TA + P+D +E LL+ E Sbjct: 63 SSIESIFEFYPDFLDKLNPECKIATIGTKTAELGIKKGLPIDIIPKD-YTAEGLLEEFER 121 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQAREV 179 ++ K + R R ++ + L GA V E Y+ + ++ Sbjct: 122 IDLNNKNVGVPRTFSARTILPEGLKNMGANVILAESYKSVIPEDTSKIEKLIQCILDEKI 181 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLV-VSERLAKLARELGWQDIKVADN 235 + TS + L+ + +++ L L V + + +LG I Sbjct: 182 DGITFTSPLTVSNLFEIAKDEDKDNLVEKLSTTTLTVAIGPITGNILNQLGVNHIY-PKR 240 Query: 236 ADNDALL 242 ++ Sbjct: 241 YTVKDMI 247 >UniRef50_Q59294 Uroporphyrinogen-III synthase n=6 Tax=Clostridium RepID=HEM4_CLOJO Length = 504 Score = 127 bits (319), Expect = 4e-28, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 87/246 (35%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP + LV +LR LG +P IE P Q +L + E + S+ Sbjct: 255 KILVTRPKESSGTLVEKLRQLGAEPVEYPCIEVVPIPQNEKLYHACENIREYGWILLTSK 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + + L+ + +G TA AL V P+ L Sbjct: 315 NGIQIFFDYLNSKGLDARVLANTKIGTVGSQTAKALKEVGLISDFTPEI-FDGRHLALGI 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + ++ LI + I + L + + Y I+ + + E+ Sbjct: 374 AERVGENEKVLICDAAIASDDIVNILRSNNIKFDRVPLYNTNYINENSNKVKKSIVHGEL 433 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS ++ + + L + + + A+ A++ + + VA+ + D Sbjct: 434 KYITFTSASTVEGFIASMKDIP----LESLTAVCIGNKTAEAAKKYNLRYV-VAEKSTID 488 Query: 240 ALLRAL 245 +++ L Sbjct: 489 SMIDKL 494 >UniRef50_B0K2L5 Uroporphyrin-III C-methyltransferase n=9 Tax=Thermoanaerobacterales RepID=B0K2L5_THEPX Length = 497 Score = 125 bits (315), Expect = 1e-27, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 88/245 (35%), Gaps = 9/245 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR +++ L G P I+ +P L + L + + D S Sbjct: 254 RILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPF--LNNIVKFLEEIHKFDYAVFTSV 311 Query: 62 HAVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V ++ L AIG TA AL + + P++ S L + Sbjct: 312 NDVWSFIEASREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEE-YTSYSLANALK 370 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + GK +L G +++ ++L A V Y+ +Y+ E+ + + + Sbjct: 371 KH-VEGKNIALLTSQIGGDILLESLGNC-ANVQKIVAYK-NEPNYEIKEKLISELRKGID 427 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + V TS + LI + L + ++ + K + G+ + + Sbjct: 428 IAVFTSSSTFNYMHQLIGDEI--NLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSEYTTEK 485 Query: 241 LLRAL 245 L+ + Sbjct: 486 LIEEI 490 >UniRef50_C0VHI0 Uroporphyrinogen-III synthase n=2 Tax=Acinetobacter RepID=C0VHI0_9GAMM Length = 258 Score = 125 bits (315), Expect = 1e-27, Method: Composition-based stats. Identities = 56/258 (21%), Positives = 99/258 (38%), Gaps = 18/258 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP + L ++ G H PL+E +L L + ++ +S Sbjct: 1 MRFINTRPQDRADRLTQAMQDAGYQVEHLPLLELIAVPLSEELQQLYQQLDQVQVIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L + +L + A+G+ TA AL Q + + E SE +L L Sbjct: 61 PTAVDIGMKYLVKSGLNLHQLAHIRWIAVGQATAKALAQFGIQSDV--PEVESSEGMLDL 118 Query: 119 PELQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P L+ ++ RG GGR+ + L +G ++ Y R E + Sbjct: 119 PLLKQQNDLQKIAFWRGLGGRQFMMQQLQQQGVKIANFVLYHRQCPQQSVFEFPRLLEKM 178 Query: 178 EVT---MVVVTSGEMLQQLWSLIPQW-YREHWLLHCRLLVVSER---LAKLAR-ELGWQ- 228 E V+++S + L Q ++ W+ LV+ ER + A+ LG Sbjct: 179 EPDQPVAVLISSEASWKNWLQLCAQNPCKQKWVY----LVLGERLTAILNQAQHSLGNTI 234 Query: 229 DIKVADNADNDALLRALQ 246 +I +N +++ + Sbjct: 235 NIIQLENLSASEIIQRMS 252 >UniRef50_B2V748 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=B2V748_SULSY Length = 237 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 94/248 (37%), Gaps = 21/248 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I++TR + EE+ G FPLI F P + L + L S+ Sbjct: 3 NIIITREASGFEEVKDLFIKAGFNPISFPLIRFEPVEIKN------FNLEDYKYLIFTSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE- 120 +AV + SQ+ + D+ A+G TA L + + I+ P + +E L E Sbjct: 57 NAVKYFFSQIPKIDK------KIIAVGEKTAKYLEKLGYKDIIVP-EVFSAEGLKAYFEK 109 Query: 121 -LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA-IHYDGAEEAMRWQARE 178 + K+ ++R + G DTL ++ Y+ I + E + + Sbjct: 110 NIDTFKDKKIALIRASEG----MDTLLNSNFKIDLIPVYETKLNIPENVDEIKSLIENEK 165 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V +V +S + ++ + + L + + + G++ V D Sbjct: 166 VYAIVFSSPSTFKGFLNIFKEE-SKKLLDKMLTVAIGKTTKNFIESQGFKVDVVPDKFTF 224 Query: 239 DALLRALQ 246 + +++ L+ Sbjct: 225 EEIVKKLK 232 >UniRef50_C9RF91 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methanocaldococcus RepID=C9RF91_METVM Length = 244 Score = 124 bits (311), Expect = 3e-27, Method: Composition-based stats. Identities = 39/249 (15%), Positives = 90/249 (36%), Gaps = 16/249 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP E + L+ FP ++ + L L E + S Sbjct: 1 MKVVITRPKERAEAFSTILKKENFDPIIFPTLKLEYNKDLK------IDLDEYGWIIFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + L +++++ + AIG TA + + G+ + +E LL+ + Sbjct: 55 PSGVIGLNNILSEKEKENVKDKKIAAIGEKTAKMVKKIFGKYPDIVPKQYTAECLLEEIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE---EAMRWQAR 177 + R L+ R+++ + L A Y+ + Sbjct: 115 KRADKNDRFLVPTTPSTRDILKNNLNA-----DLVFVYKSVEPENLKENMEVLKETLKNE 169 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 E ++ TSG + + + + + + ++ + AK+ ++ G + K+ D Sbjct: 170 ERFIITFTSGLTAKNFFKYVDDEF-YQMIKNNYIVAIGPITAKVIQKFGI-NPKIPDKYT 227 Query: 238 NDALLRALQ 246 + +L ++ Sbjct: 228 IEGMLEVIK 236 >UniRef50_C8PUY1 Uroporphyrinogen-III synthase n=1 Tax=Enhydrobacter aerosaccus SK60 RepID=C8PUY1_9GAMM Length = 262 Score = 124 bits (311), Expect = 3e-27, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 99/262 (37%), Gaps = 21/262 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP + L L G PL+ L ++ ++ +S Sbjct: 1 MQFINTRPDQRAKTLSLFLHQHGVAVIDLPLLTLVEKPLTVAERAVLQSIDRYQVVVLVS 60 Query: 61 QHAVAFAQSQLHQQDR--KWPRLPDYFAIGRTTALALHTVSGQKILYPQDR--------- 109 + AV + ++L + + + + A+G TA + Q P Sbjct: 61 EAAVKYGLARLATLVKLTELSKKITWVAVGDKTANYFNQTWQQLTELPAPTVTFPGEKRA 120 Query: 110 EISEVLLQLPELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA 168 + +E LL LP +Q++ G + RG GGREL+ DTL A+G +V YQR Sbjct: 121 QNNEGLLNLPVIQSLGKGDYLQVWRGIGGRELLADTLAAKGVQVHLLNLYQRVLPS-ATT 179 Query: 169 EEAMRWQA----REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE 224 + WQ + +V+++S Q L C LV+ R+A+ Sbjct: 180 QAFAVWQQTQSHNQPIVVLISSLTAWQNWQQLTANTEMAA---SCYYLVLQSRIAEQMLL 236 Query: 225 LGWQ-DIKVADNADNDALLRAL 245 +I + + +L+AL Sbjct: 237 QPANLNITIIPDLMPATILQAL 258 >UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepID=A5CNI5_CLAM3 Length = 279 Score = 124 bits (311), Expect = 3e-27, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 87/248 (35%), Gaps = 14/248 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALG--ESDLLFAL 59 +LV R P G+ + LR G P+I F+ Q L LA L D L Sbjct: 13 RVLVPRGGPWGDGVAYDLRAQGATPVVAPMINFAATQDAQALESALADLAAGSFDWLTVT 72 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ-- 117 S V L P A+G TTA AL P + LL+ Sbjct: 73 SATTVDV----LASHRAVVPEGTRIAAVGETTAAALVAAGYTVDFVPSIDSSATALLEEW 128 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 +R L LR + + D L ARG +V Y+ + + Sbjct: 129 TEMAAGSPRRRVLTLRSEIAKPTLTDGLIARGHDVRSVVAYRTVGVLVSD-RIREDVSSG 187 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 V ++VTSG + +Q+ + + + R AK AR G + VA Sbjct: 188 RVRAILVTSGSVAEQVHEQLGDVPD-----GVLIACIGPRTAKDARRSGVRVDVVASERS 242 Query: 238 NDALLRAL 245 +L++AL Sbjct: 243 AASLIQAL 250 >UniRef50_B2UXC3 Uroporphyrinogen III synthase/methyltransferase n=7 Tax=Clostridium RepID=B2UXC3_CLOBA Length = 491 Score = 123 bits (310), Expect = 4e-27, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 80/246 (32%), Gaps = 14/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I VTR L +LR +G IE L + L D + S Sbjct: 251 NICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTANN--LDSYMGDLENYDHIVFTSV 308 Query: 62 HAVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++V L + +L AIG+ T AL I L+++ + Sbjct: 309 NSVDIFFDYLIENKYDIRKLQAKVSAIGKATWQALERRGII-CFVKAREFIGAGLIKVLK 367 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ LI + + I D L+ GA V Y + EV Sbjct: 368 PHVKENEKVLIPCSSLAKSDIADELSNVGANVDRVFIYDTVK-----GRVRNKRAFDEVD 422 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS + + ++ + +++ + R K ELG + + D Sbjct: 423 IVFFTSPSTVYNMIDMVG----LDAIKEKQVIAIGTRTNKPLEELGIK-AYICKEHSQDG 477 Query: 241 LLRALQ 246 L ++ Sbjct: 478 FLNEIE 483 >UniRef50_D0SDM4 Uroporphyrinogen-III synthase n=1 Tax=Acinetobacter johnsonii SH046 RepID=D0SDM4_ACIJO Length = 259 Score = 122 bits (306), Expect = 1e-26, Method: Composition-based stats. Identities = 56/230 (24%), Positives = 88/230 (38%), Gaps = 10/230 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP L L + PL+E P L L + ++ +S Sbjct: 1 MLFINTRPVDRAASLTMALEQQAVEVYPLPLLELLPRAWSHDLERLYQQLVYTQVIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV F + L Q + + +G+ TA AL ++ E SE +LQL Sbjct: 61 PSAVQFGMAHLLQSGLTVSDLQHIQWITVGQKTAQALAEYGLDSVV--PKVETSEGMLQL 118 Query: 119 PELQNIAGK-RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH---YDGAEEAMRW 174 P LQN+A RG GGR+ + DTL G + Y+R + AE Sbjct: 119 PVLQNLASDASIAFWRGEGGRQFMMDTLMQHGCLILNFVLYERRCPNETMQQQAELIQCL 178 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE 224 + +++S +L+ L LV+ ERLA++ ++ Sbjct: 179 SEHNDYVALISSEASWLNWLALLD--TNIQLLQKGHFLVLGERLAQILKQ 226 >UniRef50_A5UND1 Uroporphyrinogen III synthase, HemD n=2 Tax=Methanobrevibacter smithii RepID=A5UND1_METS3 Length = 257 Score = 121 bits (305), Expect = 1e-26, Method: Composition-based stats. Identities = 43/251 (17%), Positives = 81/251 (32%), Gaps = 17/251 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + +TRP+ + + LG P ++ P L + +A D + S Sbjct: 6 VAITRPADRSKAACKIVEELGGQYVLAPTLDLKPV-NSESLKNLIANKDLLDWIVFTSPT 64 Query: 63 AVA----FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + F L D IG T + L P+D +E LL+ Sbjct: 65 TITSLNLFYPDFLKNLD------CKVAVIGNKTGKIAGEQGVKVDLIPED-FTAEGLLEE 117 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMRWQA 176 E +NI + I R R ++ + L +V E Y+ + + + + Sbjct: 118 FEKRNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSLFPMDEDKINDLIAKIEN 177 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRL--LVVSERLAKLARELGWQDIKVAD 234 E+ + TS + + + + LL L + + K+ + I D Sbjct: 178 NEIDAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIY-PD 236 Query: 235 NADNDALLRAL 245 ++ L Sbjct: 237 TYTVRDMMELL 247 >UniRef50_B3QWI2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QWI2_CHLT3 Length = 248 Score = 121 bits (305), Expect = 2e-26, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 86/250 (34%), Gaps = 15/250 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP L++ L FP IE + L L +F S Sbjct: 3 TVLVTRPKDQAGSLIAALSKFNLGCELFPTIEIAAVPGWS-----LPGLSGYAGIFFTSV 57 Query: 62 HAVAFAQSQLHQQDRKWPR---LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 ++V + + L + ++ R FA+G TA AL + P + L+ + Sbjct: 58 NSVNYLCTPLQKDFPEFAREINKLKVFAVGVKTAKALAKFNISTEELPSQAYAT-DLMAM 116 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM---RWQ 175 + + I + L +RG +I ++ G Y+ E + Sbjct: 117 IKPEEIQNNKFLFIRGTLSLGIIPAEISKHGGLCDEITVYENKIATPPPDELVRIKSLLE 176 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 ++ +V TS + L+ + ++ + + ++ + D Sbjct: 177 QGKIDCIVFTSPSTAINFFQLL---NIQSLPEKTKVASIGTTTSGALTDMNIATDIMPDY 233 Query: 236 ADNDALLRAL 245 + ++ L A+ Sbjct: 234 STSEGLAEAI 243 >UniRef50_C5V9U0 Uroporphyrinogen-III synthase n=2 Tax=Corynebacterium matruchotii RepID=C5V9U0_9CORY Length = 260 Score = 121 bits (304), Expect = 2e-26, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 80/239 (33%), Gaps = 14/239 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 + V R L++RL T G P I P L QL L G + + Sbjct: 9 KVAVLRSPEQSHSLITRLETYGAEVISIPTIRIVPPVDLTQLHHAARQLRAGTYEWVVFT 68 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLLQL 118 S +AV ++ +GR TA +L P R+ + L++ Sbjct: 69 SANAVRCIAERMTG---PLNSQTRVATVGRATARVARHYHLDPVLQPPITRQNALGLVEA 125 Query: 119 PELQNIAG---KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 E N ++ L+ N + D L ++G V Y+ Sbjct: 126 FEPANSRSEERRKILVPHANIAPSTLVDGLKSQGWIVDDIIGYRTILADPPPPNIHDLLV 185 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++T + +TSG ++ L ++ + + + L + ++LG V + Sbjct: 186 TGQITAICITSGSTIRNLITIAGRPHPQTLLA-----CIGPSAEAATKKLGLNVAVVPE 239 >UniRef50_UPI0001B5826B putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Streptomyces sp. C RepID=UPI0001B5826B Length = 542 Score = 121 bits (304), Expect = 2e-26, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 67/198 (33%), Gaps = 7/198 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R L +LR+ G V P I P + Q+ + L G + + Sbjct: 282 RVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFT 341 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + + + A+G TA AL + L P + + LL+ Sbjct: 342 SVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAALVEFGVKPDLVPSGEQSAAGLLE 401 Query: 118 -LPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 P + R + R + E + L G EV Y+ A+ Sbjct: 402 DWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPADTREAI 461 Query: 175 QAREVTMVVVTSGEMLQQ 192 + V+ TS ++ Sbjct: 462 KGGGFDAVLFTSSSTVRN 479 >UniRef50_A5EW82 Uroporphyrinogen-III synthase family protein HemD n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EW82_DICNV Length = 251 Score = 120 bits (301), Expect = 5e-26, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 99/248 (39%), Gaps = 23/248 (9%) Query: 2 SILVTRPSP---AGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 IL TR E L LR LG +H PL++ + P A L ++D L Sbjct: 13 RILYTRSKQHWLQAEPL---LRQLGAQPYHLPLLD---TKMQPLSAKALEQCRKADDLVF 66 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S AV +Q ++ + AIG TA AL + + L SE LL+ Sbjct: 67 VSAQAVQHFLAQYQPVFQQ-----NLIAIGMKTADALTAHAQTRFLVAPPPYNSEALLR- 120 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + ++ GGR+L+ TL+ EV + YQR + A ++ Sbjct: 121 --IWQPQRHKIALIAAEGGRDLLYTTLSEDN-EVYRIDTYQRFNPTH-----AWNFEMPL 172 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +++ S + L ++ PQ + ++ +S R+ + A G+ A AD Sbjct: 173 PHCILLASVQTLAHFLAITPQNMLKLLQCRAVIVALSPRIMQAAVHAGFLHCISAQYADE 232 Query: 239 DALLRALQ 246 L+ L+ Sbjct: 233 RHLISCLE 240 >UniRef50_D1Y458 Porphyrin biosynthesis protein HemD n=2 Tax=Bacteria RepID=D1Y458_9BACT Length = 483 Score = 119 bits (300), Expect = 6e-26, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 89/247 (36%), Gaps = 25/247 (10%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP+ L LR LG FP I P L +L L D + S Sbjct: 255 KVLVTRPANRQGRLSRMLRDLGAEVVEFPCIAAVP------LETKLPPLDVHDWIGFTSA 308 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V ++L + R L A+G TA AL + L P + + L Sbjct: 309 TGVECFFARLTAEGRDVRELGSAKIAAVGPATAAALRERGLRPDLIPAVYDG----VHLG 364 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G L+ R G + +TL RG + Y+ A +Q +V Sbjct: 365 AELAKRGGSVLLFRALDGSPELTETLRGRGVDFDEVPLYRT-------ETLAAPFQPADV 417 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+ TS ++ P L + + A+ A LG ++I+VA A + Sbjct: 418 DAVLFTSASTVRGFKKACP------GLEAPLACCIGVQTAREAERLGLKNIRVAARATLE 471 Query: 240 ALLRALQ 246 L+ L+ Sbjct: 472 DLVNILK 478 >UniRef50_D0J465 Uroporphyrinogen III synthase n=6 Tax=Comamonadaceae RepID=D0J465_COMTE Length = 281 Score = 119 bits (299), Expect = 7e-26, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 92/281 (32%), Gaps = 41/281 (14%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ------LADQLAALGESDL 55 +LVTRP + V R G A PLI P G Sbjct: 3 RVLVTRPLHDAKPWVDAFRARGLQAEALPLIGIGPCTDPAAHQALLRARQLALKPGHYRA 62 Query: 56 LFALSQHAVAFAQSQ----LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY-----P 106 + +S +AV + +Q + + G T AL + Sbjct: 63 VMFVSGNAVQYFFAQGQTPALDAEALLAPDTRAWTPGPGTERALLEAGLASLQIDGPSPD 122 Query: 107 QDREISEVLLQLPELQNIAGKRALILRGNG--------------------GRELIGDTLT 146 + SE L Q Q G R LI+RG GR+ + L Sbjct: 123 ATQFESEALWQNVHGQVRPGDRVLIVRGTSPATAPVADNADMSIPSTQGAGRDWLAARLR 182 Query: 147 ARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHW 205 GAEV Y+R + + + QA + ++ + +S E + L L+PQ Sbjct: 183 EAGAEVELLAVYERQLPVWTAQQLDLARQAVSDGSLWLFSSSEAVANLQQLLPQQQWHLG 242 Query: 206 LLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 L L ER+A A G+ + + D ++ +++ Sbjct: 243 LA----LTTHERIASKALSAGFGRVLHS-RPSLDDVVASIE 278 >UniRef50_C0QQD7 Uroporphyrinogen-III synthase n=1 Tax=Persephonella marina EX-H1 RepID=C0QQD7_PERMH Length = 233 Score = 118 bits (297), Expect = 1e-25, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 96/246 (39%), Gaps = 19/246 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++IL+T+ ++ + ++ + FP I+ P + D D+ S Sbjct: 2 INILITKSEKELKK-IEAVKNIRIDIIPFPAIKTIPLDFDIKTED-------FDIFVFTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + ++ + + + A+G T L + + I PQ + SE LL+L Sbjct: 54 VNAVKYFFEKIEPERLEGKQ---IIAVGDKTKAELEKIGFKNIKTPQIQ-SSEGLLELLS 109 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA-IHYDGAEEAMRWQAREV 179 +N K+ + R G +L+ L VT Y+ I + + ++ + V Sbjct: 110 NRNYKDKKIALPRAKKGIDLLIKNLD----NVTLIPVYETVLNIPENVDKVKEMFEKKLV 165 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V TS ++ + + L +++ + + K + LG + V + + Sbjct: 166 DFAVFTSPSNVENFLKIFEKGLDY--LKQTKVVPIGKTTGKKLKSLGIEPFFVPEKPSIE 223 Query: 240 ALLRAL 245 +++ + Sbjct: 224 NIIKEI 229 >UniRef50_C7M2H6 Uroporphyrin-III C-methyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H6_ACIFD Length = 490 Score = 118 bits (297), Expect = 2e-25, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 91/247 (36%), Gaps = 17/247 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFAL 59 + I+VTRP + L RLR LG V P IE P LA L+ + + D L Sbjct: 245 LRIVVTRPRAVADALAVRLRDLGAVVVASPAIEIGPPSDGGAALAAALSHIEDYDWLVLT 304 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 SQ+AV + R AIG TA AL V L P + E L+++ Sbjct: 305 SQNAVDRVVGGIGDLRRL--GGVRIAAIGPATARALERVHLTADLIPG-TWVGEGLVEVF 361 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + LI R R+++ L A+G V E Y+ E + Sbjct: 362 GPGPGS---VLIARARQARDVVPRGLEAKGWRVDVVEAYETRTAAASVPPELV----ESA 414 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +VV T+ ++ + P L+ + + GW A + D D Sbjct: 415 DLVVFTAPSTVEGFATQYP------GLVPRAAAAIGPVTEEALVRRGWPVALTATHYDAD 468 Query: 240 ALLRALQ 246 L+ ++ Sbjct: 469 GLVEVIR 475 >UniRef50_C1SL66 Uroporphyrinogen-III synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SL66_9BACT Length = 227 Score = 118 bits (296), Expect = 2e-25, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 96/246 (39%), Gaps = 22/246 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTR + L +++ G + P+IE SP + GE D S Sbjct: 1 MNVLVTREEEKYQILAEKMKAFGLTPFSLPMIECSPVGAIIT--------GEYDYAVFTS 52 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++ + + + + A+G +TA AL + + + P + +E + +L Sbjct: 53 LNSAKYFKPHISRVTIN-----KVVAVGPSTAAALLDIDIKTDIMP-ETFSAEGMKELFA 106 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +++ GK+ L + L RGAE YQ + Y + ++ Sbjct: 107 TEDVEGKKFLFAGAKVRAGDFHEYLRGRGAEPVMVATYQTQPVKYPPGYIEAFLKENKID 166 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V S + + + I ++ ++ + + A R LG+ + D+ D Sbjct: 167 IVTFASPSAARAMLADIQHIDQQ-------IVCIGKTTADEVRFLGYDS-RYPDDYTLDW 218 Query: 241 LLRALQ 246 ++R ++ Sbjct: 219 MVRLIK 224 >UniRef50_A8VZH5 PhoU family protein n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VZH5_9BACI Length = 264 Score = 116 bits (291), Expect = 7e-25, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 85/251 (33%), Gaps = 11/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL TR + L RL G PLI + + + + A +D++ S+ Sbjct: 9 RILNTRAPHQQKALTDRLTAWGADVVELPLIRVERVKGV-SVREFREAFEAADVVVFTSR 67 Query: 62 HAVAFAQSQLHQQDR-----KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +AV L + + + A+G T L + P D + L Sbjct: 68 NAVEVTMDLLKEACQTDDYTRCFEGKVIAAVGEKTGDVLMASGLTPSIMP-DVFEAGHLA 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + Q G R R+ + LT G VT Y + + ++ Sbjct: 127 RSIVDQTAPGAEIFYPRSEKARKTLPKALTEAGRHVTELVIYTTKSQTIPSDKITELFEG 186 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSER-LAKLARELGWQDIKVADN 235 + ++ S +Q + + + + V+ER L +E + + V + Sbjct: 187 DGLDVITFMSPTAVQSFFQQMDPALVPDDVRFAVIGEVTERALRPYVKE---ERLIVPER 243 Query: 236 ADNDALLRALQ 246 + ++RA++ Sbjct: 244 YTLEDMIRAIE 254 >UniRef50_C1DT10 Uroporphyrinogen-III synthase n=2 Tax=Sulfurihydrogenibium RepID=C1DT10_SULAA Length = 241 Score = 115 bits (289), Expect = 1e-24, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 88/248 (35%), Gaps = 16/248 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+TR EE+ S G FP I+F L + D L S+ Sbjct: 3 NVLITREKGQFEEVKSIFEKEGFNPIPFPTIKFEKLP-LDNFDE-----KNYDYLIFTSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP-- 119 +AV F + K A+G TA L + I P D E L Sbjct: 57 NAVKFFLEDIEVDKSK-----PVIAVGSKTANYLKKEGFKNIEIP-DAFSGEGLKDYIDK 110 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW-QARE 178 L GK+ ++R G +++ + + + V Y+ D EE + +E Sbjct: 111 NLDRFKGKKFGLIRALEGSQVLLNQ-SGKDYFVQLLPIYKTTYNIPDNTEEIEKLFLKKE 169 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + VV +S ++ + +L + + +K + G++ V Sbjct: 170 IYAVVFSSPSTFYGFLNVFGVEKSKKFLEDVLVCTIGTTTSKALEDKGFKVNIVPQIFTF 229 Query: 239 DALLRALQ 246 + +++ L+ Sbjct: 230 EEIVKLLK 237 >UniRef50_C5U4M5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Methanocaldococcus infernus ME RepID=C5U4M5_9EURY Length = 230 Score = 114 bits (285), Expect = 3e-24, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 90/246 (36%), Gaps = 19/246 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+++VTRP + L G P +E + L D++ S Sbjct: 1 MNVIVTRPEDVAKSFCQLLTKKGYSVIKIPCLEI-------RYKKVKINLDNYDIIAFTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V L + +R+ + IG TA + + + +E LL+ E Sbjct: 54 PRGVKGLYLNLSEDEREKVKEKIIACIGEKTAKKVEELFKKSPEIVPSEYRAEKLLE--E 111 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ + GK LI R+++ R T+ Y+ + E+ + + + Sbjct: 112 IKKVEGK-ILIPTTRATRDVL------RVLHPTYIYVYESLEPE-NLKEKVLSLKNLDTF 163 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TSG + + + + ++ + ++ + A+ + G I VA + Sbjct: 164 IITFTSGLIAENFLKYVDEELKKKIEENY-IIAIGPVTAERVKRFGLNPI-VAKKYTIEG 221 Query: 241 LLRALQ 246 +L A++ Sbjct: 222 ILEAIE 227 >UniRef50_Q3IBM6 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=uncultured sulfate-reducing bacterium RepID=Q3IBM6_9BACT Length = 518 Score = 114 bits (285), Expect = 4e-24, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 84/246 (34%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP+ L LR LG +P + + + + S+ Sbjct: 261 RVMVTRPADQSVALYGDLRELGAEVLAYPTLATVEDFRSDDWDALRRIQEKERWVVFTSE 320 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + Q D + A G TA +L+ + P ++ + Q+ Sbjct: 321 NGVRYFLEQWFATIGDIRGLNDYRIAAAGDGTARSLNANNLAPDFVPTRASMAALAQQMA 380 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E ++ + +RGN + I L GA+V Y+ + A + A Sbjct: 381 EKVPMSKATVVRVRGNARNDPIERALRETGAQVVSLPVYRTFPTKWRSA-VKEKLFAYPP 439 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++ TSG + L + + + ++ + ++ R G + Sbjct: 440 DVILFTSGTAVDGLAANLSARELKELSSGAAVVSIGPATSRTIRTHGITVELESKVHTMP 499 Query: 240 ALLRAL 245 +LL L Sbjct: 500 SLLEEL 505 >UniRef50_A8MGE5 Uroporphyrin-III C-methyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MGE5_ALKOO Length = 496 Score = 111 bits (279), Expect = 2e-23, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 80/249 (32%), Gaps = 22/249 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP +L L LG +P I D + + S Sbjct: 260 KILITRPKQTIGKLSQMLWELGAETVEYPCIR-------TSTIDFDLNMNHLQWIVFTSA 312 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL-QL 118 V +L + D + +G TA L + P +E L +L Sbjct: 313 VGVKAFFDKLFTMKMDSRCLHDKKIAVVGSETAAELLKYGIRADFIPS-VFDAEHLATEL 371 Query: 119 PELQNIAGK-RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 I K + + R G E + LT EV+ Y+ + + Sbjct: 372 LNSGQITSKDQVGVFRAKTGSEDLVRILTDHNVEVSDVAVYETNYVKNHKIDV------N 425 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + V TS +Q + + + + ++ A +A++ G + ++D A Sbjct: 426 KFDYVAFTSASCVQGFVESFGEDADFSSVNA---VCIGKQTASMAKQYGM-NTTISDIAT 481 Query: 238 NDALLRALQ 246 ++ ++ Sbjct: 482 ISGIVDKIK 490 >UniRef50_Q2IKT0 Uroporphyrinogen-III synthase n=4 Tax=Anaeromyxobacter RepID=Q2IKT0_ANADE Length = 264 Score = 111 bits (278), Expect = 3e-23, Method: Composition-based stats. Identities = 57/249 (22%), Positives = 84/249 (33%), Gaps = 9/249 (3%) Query: 2 SILVTRPSPA--GEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 +++VTR + + L RL LG P I F+P L L L D Sbjct: 13 TVVVTRGKGSEGKDALAVRLEELGAEVRALPSIAFAPPADPAPLDAALRGLERFDWAVFT 72 Query: 60 SQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV +L L A+G TA L + + P + + +L Sbjct: 73 SANAVDRTVERLRALGLAPAALGRLRLAAVGPATAERLAALVRAPDVVPVEAKG--DVLA 130 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW-QA 176 + + G+R L R GR L A GAE+T E Y+ + W A Sbjct: 131 RTLGEQVRGRRVLFPRPAEGRPETVAGLLAAGAELTAVEAYRTMPAPPEALGCLAGWLAA 190 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 EV V S + + + R L + + A RE G V + Sbjct: 191 GEVAAVAFASPSAVAAVVGALGD--RSALLRGVLIAAIGPTTADALREAGLPVGAVPAHY 248 Query: 237 DNDALLRAL 245 L A+ Sbjct: 249 TGRDLAEAI 257 >UniRef50_C5ABI2 Uncharacterized enzyme of heme biosynthesis n=5 Tax=Burkholderia RepID=C5ABI2_BURGB Length = 757 Score = 111 bits (277), Expect = 3e-23, Method: Composition-based stats. Identities = 41/133 (30%), Positives = 58/133 (43%), Gaps = 6/133 (4%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD--GAEEAMRWQA 176 P +AGKR LI+RG+GGRE + L GAEV Y+R E Sbjct: 230 PPAGPLAGKRVLIVRGDGGREWLATRLREAGAEVELVAAYRRIVPEPSIGAWERVHALLG 289 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREH---WLLHCRLLVVSERLAKLARELGWQDIKVA 233 +VTS E ++ L L LLH L+ R+A AR LG+ I + Sbjct: 290 GAPHAWLVTSSEGVRNLHELAVDHLTAAEIEALLHAPLVAPHSRIADTARALGFDRITQS 349 Query: 234 DNADNDALLRALQ 246 A ++ ++RA + Sbjct: 350 -GAGDERIVRAFR 361 Score = 81.4 bits (200), Expect = 2e-14, Method: Composition-based stats. Identities = 28/139 (20%), Positives = 49/139 (35%), Gaps = 22/139 (15%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + ++T+P L ++L G ++ FPLI+ +P L A L L+ +S Sbjct: 7 FTAVLTKPEGQSAALAAQLAAAGIESFDFPLIDIAPATDFGPLDAAFARLDAYALVVFVS 66 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK----ILYP---------- 106 +A+ A ++ WP +G + AL ++ P Sbjct: 67 PNAIDRALARF---GAIWPHSLPVGVVGPGSVAALARHGIAAPAHRVIAPDGALAPAGAA 123 Query: 107 -----QDREISEVLLQLPE 120 + R SE L E Sbjct: 124 GTDGGEPRYDSEGLYAQIE 142 >UniRef50_B2J0U6 Uroporphyrinogen III synthase HEM4 n=6 Tax=Cyanobacteria RepID=B2J0U6_NOSP7 Length = 300 Score = 110 bits (276), Expect = 4e-23, Method: Composition-based stats. Identities = 41/259 (15%), Positives = 88/259 (33%), Gaps = 23/259 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVT P L ++ G + P IE +L L + E D + S+ Sbjct: 39 RILVTAPRNYAYRLSEQIIKQGGLPVFMPTIETCYLSNYAKLDAALNHIAEFDWIVFTSR 98 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + + +++ + A+G+ A +L + G+ L P + + ++ +L Sbjct: 99 NGITAFFHRMNDLNIPVSVVEKCQLCALGKD-AESLLSFCGKVDLIPTESSPAGIVAELA 157 Query: 120 ELQNIAGKRALILRGNGGREL-----------IGDTLTARGAEVTFCECYQRCAIHYDGA 168 ++ I K+ LI E+ + L G EV Y ++ Sbjct: 158 KIPQIHNKKVLIP----APEVVGLPEPDVVPNLITDLQQLGTEVIRVPTYITQGLNTSIY 213 Query: 169 EEAMRW-QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW 227 + + ++ +S ++ +++ C + AR+LG Sbjct: 214 SIELNLIHQGMIDVIAFSSTAEVESFLTMVNSQSDYEG---CIVACFGPYTTANARKLGV 270 Query: 228 QDIKVADNADN-DALLRAL 245 V+ + + + A+ Sbjct: 271 NVSIVSRDYSSFEGFAEAI 289 >UniRef50_A8UZZ5 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8UZZ5_9AQUI Length = 228 Score = 110 bits (276), Expect = 4e-23, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 84/245 (34%), Gaps = 20/245 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL+TR +L + + PLI+ + + P L + D L S+ Sbjct: 3 NILITREEKLDNKLEKIAKEKDLNIIYCPLIKTTKIEFNPP------DLDKYDYLIITSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + + + A+G T L + +I+ P+ + + +L + Sbjct: 57 NAVKYFLKSIPLEKI---LHKKVIAVGEKTKKYLKNLGFDEIIIPEI-NSARGIEKLIQE 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA-IHYDGAEEAMRWQAREVT 180 + K+ L +R G+E+ L Y+ + E + E+ Sbjct: 113 KQFKDKKFLFIRAEKGQEINNKNL-------DLLIVYKTIFNKPENYKECSKLLIKGEID 165 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V+ +S + E L + +++ + K G+ V + Sbjct: 166 YVIFSSPSTFYSFMENFKNY--EKLLNNTKIITIGNTTKKAVESKGFNVYFVPKKPSFEE 223 Query: 241 LLRAL 245 ++ AL Sbjct: 224 IINAL 228 >UniRef50_A5WHR1 Uroporphyrinogen-III synthase-like protein n=1 Tax=Psychrobacter sp. PRwf-1 RepID=A5WHR1_PSYWF Length = 289 Score = 110 bits (275), Expect = 5e-23, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 75/220 (34%), Gaps = 10/220 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ----QLPQLADQLAALGESDLL 56 M + TRP + L ++ G PL+E + + + + L Sbjct: 1 MIFINTRPIERAQPLTQAMQDKGLTVLELPLLELTAIEIGQREQQYQQHFYQQPDQYQAL 60 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +S A L + A+G TA L Q + P + +E ++ Sbjct: 61 VVVSPTAARMG---LAACPIGFVPRCAVIAVGHATAEVLRVAGWQ-VHCPVE-YSNEGMM 115 Query: 117 QLPELQNIA-GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 +P+L + G R L+ RG GGR ++ + L G V YQR + Sbjct: 116 LMPQLNRLGVGNRILVWRGRGGRRVLVNFLQENGVGVDAIAWYQRQCPPQAEHDFKQLLP 175 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVS 215 ++ V + + P + H L+++S Sbjct: 176 QLGLSEVAKLPDAINLNSLHISPLDNPDANSKHKPLVLIS 215 >UniRef50_C2C1P1 Uroporphyrinogen-III synthase n=1 Tax=Listeria grayi DSM 20601 RepID=C2C1P1_LISGR Length = 242 Score = 109 bits (274), Expect = 6e-23, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 82/247 (33%), Gaps = 20/247 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + ++TR + E+ + LG A PLIE + E D +F S Sbjct: 6 TFVLTRTAADNEKWLPYFHELGVEAVSLPLIETKALPFQIE--------KEYDWIFFTSA 57 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ + + IG TA AL + P ++E L+ Sbjct: 58 KAIHYFAEKYDLAVVT----AKIAVIGEKTAEALIRYGRKADFEPS-SYVAETFLEEWLP 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q A KR L R + RE+I TL +G V + Y+ A Q + + Sbjct: 113 QYSADKRILFPRSSLAREVIAKTLREQGYSVEEIDIYETVIPASSSNLFAALIQTEKDFL 172 Query: 182 VVVTSGEMLQQLWSLIPQWYR--EHWLLHCRLLVVSERLAKLARELGWQ-DIKVADNADN 238 + S ++ + + W + ++ G + AD Sbjct: 173 FLFASPSAWHNFEAICQTRNQSVQAWEYGS----IGPITSRAIEASGCSVKYQPADTYTM 228 Query: 239 DALLRAL 245 +A+++ + Sbjct: 229 EAMIQEI 235 >UniRef50_D2RNT3 Uroporphyrin-III C-methyltransferase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT3_ACIFE Length = 489 Score = 109 bits (274), Expect = 7e-23, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 89/248 (35%), Gaps = 20/248 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVT E+ L ++G+ P++E P + L S+ Sbjct: 253 KILVTGTPVFCGEVARALASVGKTVTELPILELEPL-----FQNIPEDFDRYGWLVFTSR 307 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + + RL + IG+ TA L Q L P + +E L +L Sbjct: 308 NGVRLFFRWFRSARQDFRRLGQVRFACIGQGTAEELADQGFQADLMP-EVFTAEDLGRLL 366 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDGAEEAMRWQARE 178 AG R L+LR G + L G + Y+ R GAE + Q Sbjct: 367 GETLEAGDRCLLLRAEEGSPDLVRELDRAGRKYRDVPLYRIRTRKILTGAETRLAPQ--- 423 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +++ SG +++ + R R+L + A+ ARE G ++ A Sbjct: 424 --VMIFGSGRGVREFFR------RFTLAPETRVLCIGPVTARAAREAGCSQVETAAIHSA 475 Query: 239 DALLRALQ 246 + AL+ Sbjct: 476 AGIRDALE 483 >UniRef50_B9DNE0 Putative uroporphyrinogen III synthase n=1 Tax=Staphylococcus carnosus subsp. carnosus TM300 RepID=B9DNE0_STACT Length = 229 Score = 109 bits (274), Expect = 7e-23, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 76/228 (33%), Gaps = 17/228 (7%) Query: 19 LRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKW 78 +++ + H P I+ P L + D + S++AV + + Q + + Sbjct: 13 IKSEDEDIIHLPFIKIKPLSFNEALLNH-----HYDWIIFSSKNAVKYFRDYFQQLNVDY 67 Query: 79 PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGR 138 AIG T + V +P++ E + E + G R +I R Sbjct: 68 -----VAAIGEKTKDYCNQVGISVDFFPKN-FSQEGFID--EFKVNQGDRIIIPSSAAAR 119 Query: 139 ELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIP 198 + L + AEV + Y+ A + + + + S + Sbjct: 120 PFLQKELQEKNAEVVKIDLYEPEAYTENILQAISLLKRNLANGIAFASSSAADNFFK--- 176 Query: 199 QWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 + + + + + E G+ K+A+ D LL+ ++ Sbjct: 177 EAENLNLDSNYNYYAIGRPTFEKIEEYGYT-AKIAEEQTIDGLLKIIK 223 >UniRef50_A8UVV3 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8UVV3_9AQUI Length = 244 Score = 109 bits (272), Expect = 1e-22, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 76/235 (32%), Gaps = 17/235 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR E PLI P L Q+ + + S Sbjct: 8 RVILTRSVEDIERDRKLFEKYRFEVVELPLIRTEP------LDFQVPK-DSYEYVVFQSA 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV P+ A+G T L + + L P+D +E ++ E Sbjct: 61 KAVKHFLKS-----SDIPKGVKVIAVGNRTREELERLGYKVWLVPKD-MSAEGVVN--EF 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ LI R GR+ + L+++G V Y+ + Y E + Sbjct: 113 PLGRGETVLIPRSEQGRDEAVEGLSSKGYRVVTINVYRTSKVSYSEEEVVSILKGGG--F 170 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +V S ++ ++ + + + L ++ + + K + G V Sbjct: 171 IVFASPSAVRSFFANLRKGTAKAVLNDLVVVSIGKTTKKELEKFGVTPAIVPPKP 225 Score = 49.5 bits (117), Expect = 1e-04, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 38/114 (33%), Gaps = 5/114 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAA-LGESDLLFALS 60 ++L+ R +E V L + G I ++ +++ + L + S Sbjct: 119 TVLIPRSEQGRDEAVEGLSSKGYRVV---TINVYRTSKVSYSEEEVVSILKGGGFIVFAS 175 Query: 61 QHAVAFAQSQLHQ-QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISE 113 AV + L + + +IG+TT L + P + E Sbjct: 176 PSAVRSFFANLRKGTAKAVLNDLVVVSIGKTTKKELEKFGVTPAIVPPKPLMEE 229 >UniRef50_Q83H96 Porphyrin biosynthesis protein n=2 Tax=Tropheryma whipplei RepID=Q83H96_TROW8 Length = 241 Score = 108 bits (271), Expect = 1e-22, Method: Composition-based stats. Identities = 45/252 (17%), Positives = 89/252 (35%), Gaps = 31/252 (12%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + +TR E+ L+ G + P+I+ P ++L + D L S Sbjct: 8 VWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGY---ENELQKIPFFDWLIVTS-- 62 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 + + P+ A+GR TA +L + L P++ S+ L + Sbjct: 63 -----STTAGLLNTPIPQSVKVAAVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAH 117 Query: 123 ---------NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 ++ +R LIL + + L G +VT Y+ + + Sbjct: 118 LNFPRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLVIYKTVILDIPPMPQL-- 175 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 +T VTSG + Q + L+ + + A++ + G + +A Sbjct: 176 ---DNITAAFVTSGSIAQGIAKT-------GLFFDLPLVCIGHKTAEICQRSGLRVASIA 225 Query: 234 DNADNDALLRAL 245 + + L++AL Sbjct: 226 RTKNKEGLVQAL 237 >UniRef50_C7R377 Uroporphyrinogen III synthase HEM4 n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R377_JONDD Length = 284 Score = 108 bits (271), Expect = 1e-22, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 85/258 (32%), Gaps = 15/258 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLAALGESDLLFAL 59 + L+ RP L++R+ G PLI P Q L AAL + Sbjct: 12 TTLILRPEGRATPLITRITHAGGHTVTAPLITREPITTDQRATLDTHTAALHTYAWVAVT 71 Query: 60 SQHAVAFAQSQLHQQDRKWPRLP-----DYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S +AV + + + P + ++G T AL + S + Sbjct: 72 SVNAVDELIASIQRTHPTTPLTTVCTTTQWASVGPATTRALRAHGITVAWEATENSASGM 131 Query: 115 LLQLPELQNIAGKR--ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM 172 L Q P R L+ GN + LT+ G T Y A H Sbjct: 132 LAQWPAANTHTDPRTAVLLPLGNLATTQLETGLTSAGYTPTRVTTYLTVA-HPAPPSALA 190 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQ----WYREHWLLHCRLLV-VSERLAKLARELGW 227 W+A + V++TSG +++Q + + V + E + A+ Sbjct: 191 AWRAGRIDAVILTSGSIVEQFVAQFGHPSPGPGPAQGNEDRPVFVAIGEPTRRAAQRHSL 250 Query: 228 QDIKVADNADNDALLRAL 245 VA A L+ AL Sbjct: 251 PIDAVARQASTAGLVDAL 268 >UniRef50_Q0ST17 Uroporphyrinogen-III methyltransferase/synthase n=25 Tax=Clostridium RepID=Q0ST17_CLOPS Length = 492 Score = 108 bits (271), Expect = 1e-22, Method: Composition-based stats. Identities = 44/228 (19%), Positives = 81/228 (35%), Gaps = 13/228 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I +TR +E+ +L+ LG I+ + L + + L + D + S Sbjct: 252 NICLTRSKEQSKEIKWKLKELGAEVTEINSIKIKETSEN--LDEYINTLEKYDHIVFTSV 309 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAI-GRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV L ++ ++ FA+ G+ T AL + +E L ++ + Sbjct: 310 NAVNVFFDYLVKKRVDIRKIKADFAVLGKATKKALIARGIVPSIM-AHSFTAEGLFEVLK 368 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G+ LI + RE + D L + GA+ Y EV Sbjct: 369 DNIKEGEEVLIPCSSLSREYLFDNLASLGAKCHRVNIYDTICGDVKNPRAFK-----EVD 423 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ 228 MV+ TS ++ + +I L + + K E G + Sbjct: 424 MVLYTSPSTVKNMIDMIGLES----LKEKVSIAIGPITLKALNESGIE 467 >UniRef50_Q1IWF9 Uroporphyrin-III methyltransferase and synthase domains n=4 Tax=Bacteria RepID=Q1IWF9_DEIGD Length = 507 Score = 108 bits (270), Expect = 2e-22, Method: Composition-based stats. Identities = 53/236 (22%), Positives = 78/236 (33%), Gaps = 16/236 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++ VTR L LR G PLI F+ + L +L L L S Sbjct: 263 TVAVTRTREGASALSELLRARGASVLEVPLIRFAATENAAALQTRLRDLSGVTWLLLTSN 322 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV + L L A+G +TA +L + P + +QLP Sbjct: 323 QAVTALFAHLEHLGLDARHLAGVKVAAVGPSTARSLAEQGLRADFVPSTPGARYLGVQLP 382 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G+ AL L + TL ARG E Y+ E + R Sbjct: 383 AR---PGEVALHLTSQVAEAELQQTLEARGIRYERAELYRTEPARLSTPELE---RLRGA 436 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +V + SG + L +L + + + A AR G+ + VA Sbjct: 437 DVVTLASGSAARHLAALAG--------TDFTVAAMGPQTADAARAAGFTRVTVARE 484 Score = 47.9 bits (113), Expect = 3e-04, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 42/115 (36%), Gaps = 1/115 (0%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 +AG+ + R G + + L ARGA V + A A + VT ++ Sbjct: 259 LAGRTVAVTRTREGASALSELLRARGASVLEVPLIRFAATENAAALQTRLRDLSGVTWLL 318 Query: 184 VTSGEMLQQLWSLIPQ-WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 +TS + + L++ + L ++ V A+ E G + V Sbjct: 319 LTSNQAVTALFAHLEHLGLDARHLAGVKVAAVGPSTARSLAEQGLRADFVPSTPG 373 >UniRef50_Q4FVJ4 Possible uroporphyrinogen-III synthase n=2 Tax=Psychrobacter RepID=Q4FVJ4_PSYA2 Length = 327 Score = 108 bits (269), Expect = 3e-22, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 104/300 (34%), Gaps = 59/300 (19%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFALS 60 ++ TRP L L+ G P++ P + GE L +S Sbjct: 27 VINTRPVERAAPLTRHLQAAGMSVIDMPMLTLQPRSTTDNDMILMRQWLAGEYQALVIVS 86 Query: 61 QHAVAFAQSQLHQQDRK--------------------WPRLPDYFAIGRTTALALHT--- 97 A A + +R+ A+G TA L+ Sbjct: 87 PTAAASGLAIWQLLERERQANGATDKAVEGIEDSLGVLVAPSHLIAVGEATAAVLNEVKL 146 Query: 98 -VSGQKILYPQDREISEVLLQLPELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFC 155 + ++L P E +L +PE+ ++ AG + L+ RG GGR L+ DTL ARG + Sbjct: 147 PFASYQVLQPAIANN-EGMLSMPEIDSLQAGDKLLVWRGLGGRRLLVDTLQARGVHIDSI 205 Query: 156 ECYQRCAIHYDGAEEAMRW---------------QAREVTMVVVTSGEMLQQLWSLIPQW 200 Y+R D + +W + +V+V+SG + S++ Sbjct: 206 AWYERKIP-VDAMAQYQQWLQDFDSQNAIGGITISQQAKPIVIVSSGTAFEHWQSIVQAT 264 Query: 201 YREHW--------------LLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 + L +V+ ERLA + E +V ++ + +L A+ Sbjct: 265 KTLNLAAENQAMSVNVTLELSDFAYVVLGERLANMVAEQHLSYWRV-EDLAPETILAAIN 323 >UniRef50_C7I1F1 Bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase n=1 Tax=Thiomonas intermedia K12 RepID=C7I1F1_THIIN Length = 335 Score = 108 bits (269), Expect = 3e-22, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 102/316 (32%), Gaps = 76/316 (24%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++ TR S L G FPL P LP+ LAAL ++DL +S Sbjct: 5 TLISTRASSQSGGAHELLAAAGVQMLDFPLQHIGPPGDLPRFHAALAALPQTDLAIPVSP 64 Query: 62 HAVAFAQSQLHQ---------------------------QDRKWPRL--PDYFAIGRTTA 92 AVA + L Q D WPRL P G+ A Sbjct: 65 TAVAAVFAALRQPWPARCAIGVVGEGSLRAVRRALTAQPDDAPWPRLIAPGSAPPGQGFA 124 Query: 93 L-------------------------------ALHTVSGQKILY-----PQDREISEVLL 116 + G+ + P SE L Sbjct: 125 QPAPRGGQENLGRPGVFLRAPQGRASPSPPPEGVKETWGRPCVSLRGDEPGGEGDSEALW 184 Query: 117 QLPELQ---------NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG 167 +L AG+ ALI RG GR+L+ L A GA+V E Y R A Y+ Sbjct: 185 NALQLAFAPGPVASFPWAGRHALIFRGGPGRDLLLRKLEAAGAKVKVIEAYSRLAPEYNA 244 Query: 168 AEEAMRWQA-REVTMVVVTSGEMLQQLWSLI-PQWYREHWLLHCRLLVVSERLAKLAREL 225 A+ A + +S E + L L+ P L R L + R+A E Sbjct: 245 QTAALLQTALGSGGWWLFSSTEAVHNLQRLLEPAGLDADVLHPQRALAIHPRIASALSEA 304 Query: 226 GWQDIKVADNADNDAL 241 G+ +++ + L Sbjct: 305 GFGRVELTRAPLEEVL 320 >UniRef50_D0LW22 Uroporphyrin-III C-methyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LW22_HALO1 Length = 525 Score = 107 bits (268), Expect = 3e-22, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 80/258 (31%), Gaps = 14/258 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +LV R +RLR LG P+ + + Q+ S Sbjct: 260 LRVLVPRAEHQAASFAARLRELGAEPVLMPVTRVAAPAEPDPAWAQVLE-SSYTWTIFTS 318 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV + L + R L +GR T AL L P+ + + V + Sbjct: 319 ANAVEQFFAALRARGRDARFLGGARLACVGRATEAALAAQGLICDLLPERGDAAGVAAAV 378 Query: 119 PEL-----QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE--- 170 +++A +R L+ R GRE L A G V Y+ D Sbjct: 379 LAASEAAGESVAAQRVLLPRAAEGREEAIAALRAAGCAVQPLTVYRSETTPSDHPSVEDG 438 Query: 171 AMRWQAREVTMVVVTSGEMLQQLWSLIPQWY--REHWLLHCRLL-VVSERLAKLARELGW 227 + + V + +Q L + + + C ++ + + G Sbjct: 439 VHALRTGAIDAVAFFAPSQVQALLDIAEAAGLTQAEVVERCAIVAAIGATTQAALEQRGI 498 Query: 228 QDIKVADNADNDALLRAL 245 + + L+ AL Sbjct: 499 AVHAAPERPEAALLVEAL 516 >UniRef50_C5EV70 Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=3 Tax=Clostridiales RepID=C5EV70_9FIRM Length = 512 Score = 107 bits (267), Expect = 4e-22, Method: Composition-based stats. Identities = 37/256 (14%), Positives = 70/256 (27%), Gaps = 16/256 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + +T +L + L G ++ + + L L S Sbjct: 255 RVGITGTEQFAGKLAAALSEQGAQVSWLVNMKVEDHIEEAPMQAAYRNLPSYTWLVFTSA 314 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V L + R L + IG T L P D ++ L Sbjct: 315 NGVRLFFQGLFKDGRDCRCLGHVKFAVIGDGTGRELSGYGFNADYMP-DAYCAKALADGL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G R LI R GG ++ TL G Y+ + Sbjct: 374 VHAVSPGDRLLIARSAGGSPILAQTLLNAGIHFDDIVLYE-VTGQPSASFIPEEVMGF-- 430 Query: 180 TMVVVTSGEMLQQLWSLIPQ----------WYREHWLLHCRLLVVSERLAKLARELGWQD 229 + S ++ + + Q + +L+ + A+ G++ Sbjct: 431 DYITFASASGVRAFFDCLTQGGTGDKAVGIQGPAVHPKNPKLVCIGAVTARELERQGYKA 490 Query: 230 IKVADNADNDALLRAL 245 A + L++A+ Sbjct: 491 DITAAQYHIEGLVKAI 506 >UniRef50_Q0W5T0 Uroporphyrinogen-III synthase n=1 Tax=uncultured methanogenic archaeon RC-I RepID=Q0W5T0_UNCMA Length = 256 Score = 107 bits (267), Expect = 5e-22, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 87/253 (34%), Gaps = 12/253 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 I VTRP + V L+ G A P++E P L L GE+D + Sbjct: 3 RIAVTRPRKFLPDTVRILKEKGLEAVPVPMMEMIPRND-GALEAFFKRLEAGEADTVIIT 61 Query: 60 SQHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 SQ+ V F + +L + IG T L + P SE L+Q Sbjct: 62 SQNGVQFIYDKAPDPAALTKQLNSVEVIGIGPRTNSVLTERGITHLQMPG-TFSSEGLVQ 120 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-YDGAEEAMRWQA 176 + GKR +LR N G ++ L A GA+V Y + + A Sbjct: 121 -DFCAKLKGKRVEVLRSNHGNPILISGLEAGGAKVREIIVYDIVPLKGEEQAAFVREALE 179 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLH----CRLLVVSERLAKLARELGWQDIKV 232 + TS + L + L ++ V+ A ++ G + V Sbjct: 180 GRIDAYTFTSTMTARSLLMMGESMGVLDPLKREINSKKVAVIGHPTADFLKKSGIRVDAV 239 Query: 233 ADNADNDALLRAL 245 + + ++ AL Sbjct: 240 PERFTFEDMVEAL 252 >UniRef50_B3DZQ5 Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=3 Tax=cellular organisms RepID=B3DZQ5_METI4 Length = 514 Score = 106 bits (266), Expect = 5e-22, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 85/247 (34%), Gaps = 6/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGE-SDLLFALS 60 ++VTR + +L+ LG P I P + +L + D L S Sbjct: 260 RVVVTRTKEGSARIAKKLQELGAEVLEIPTIRIVPSSLGDEQIRRLKKIEAFYDWLLFTS 319 Query: 61 QHAVA--FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 V F D + + AIG TTA A+ + P+ S L + Sbjct: 320 PTGVEIFFGHYLRLTGDIRGLKGIKIGAIGLTTAQAIGRYHLAVEVIPEK-FTSMDLARC 378 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 +NI G+R L+ R E I LT+ GA V Y D ++Q Sbjct: 379 FLGKNIEGERFLLPRSTMADEGIVKFLTSLGACVEQWALYDIQPETEDFRGGREKFQKEG 438 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ S ++ L + L ++ + + + ++L + + + Sbjct: 439 ADWILFASASSVKYWNRLNLSCHDTSLLPK--VISIGPQTTRALQDLHQEVYRESKIHTI 496 Query: 239 DALLRAL 245 D L+ L Sbjct: 497 DGLIETL 503 Score = 41.7 bits (97), Expect = 0.020, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 43/120 (35%), Gaps = 7/120 (5%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 LQ E + + G+R ++ R G I L GAEV R G E+ R + Sbjct: 248 LQWFEKKPLYGQRVVVTRTKEGSARIAKKLQELGAEVLEIPT-IRIVPSSLGDEQIRRLK 306 Query: 176 ARE--VTMVVVTSGEMLQQLW-SLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 E ++ TS ++ + + L ++ + A+ +G + V Sbjct: 307 KIEAFYDWLLFTSPTGVEIFFGHYLRLTGDIRGLKGIKIGAIG---LTTAQAIGRYHLAV 363 >UniRef50_A5KJC6 Putative uncharacterized protein n=4 Tax=Bacteria RepID=A5KJC6_9FIRM Length = 515 Score = 106 bits (265), Expect = 7e-22, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 88/254 (34%), Gaps = 19/254 (7%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFP---LIEFSPGQQLPQLADQLAALGESDLLFALS 60 LVTRP L RLR LG P + P ++L + ++ + + S Sbjct: 260 LVTRPRQNSSALAKRLRNLGAQVIEMPSIHTVAIDPNERLKKALGEIQHSEKEEWFVFTS 319 Query: 61 QHAVAFAQSQLHQQDRKWPRLP------DYFAIGRTTALALHTVSGQKILYPQDREISEV 114 V QL ++ RL AIG TA AL + P+ E Sbjct: 320 PIGVHVFFEQLEKEAWDMRRLLAGKAQIKIAAIGSATAAALKEHGLFADIVPKIYNAGE- 378 Query: 115 LLQLPELQNIAGKR-ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAEEA 171 L +NI+ I R G + L G V Y+ + Sbjct: 379 -LGKTLAENISEYSAVTIFRAEEGSLELLPPLMETGVPVNDIALYRTEYEVSSLLRHKIE 437 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 +Q E+ V TS ++ I L + + + E+ A AR+ G + I+ Sbjct: 438 KMFQKEEIDAVTFTSASTVKGFVKAIKNVE----LQNVSAVCIGEQTAAEARKYGMK-IQ 492 Query: 232 VADNADNDALLRAL 245 VA AD DA+ + Sbjct: 493 VAKRADMDAMTEKI 506 >UniRef50_B8DHJ3 Uroporphyrinogen-III synthase n=18 Tax=Listeria RepID=B8DHJ3_LISMH Length = 240 Score = 106 bits (264), Expect = 9e-22, Method: Composition-based stats. Identities = 36/195 (18%), Positives = 70/195 (35%), Gaps = 11/195 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR + + + G PLI+ P + E++ LF S Sbjct: 4 KVVLTREASKNQPWQTYFGQNGFAVVSVPLIKTRPKKISLSREQL-----EAEWLFLTSA 58 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + ++ IG T L + P SE+ L+ Sbjct: 59 NAVEYFF-----MNQPGEAHYKIAVIGEKTREKLAEFGYKPSFVPSI-YQSEIFLEEWLN 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +N L+ + N R +I DTLT +G V E Y+ + + + ++ + Sbjct: 113 ENPEKTSVLLPQSNLSRSIIKDTLTEKGYLVHSVELYETVSPENSKIKLTELLNSNDIHI 172 Query: 182 VVVTSGEMLQQLWSL 196 ++ S + +S+ Sbjct: 173 IIFASPSAWKNFYSI 187 >UniRef50_O67647 Putative uncharacterized protein n=1 Tax=Aquifex aeolicus RepID=O67647_AQUAE Length = 250 Score = 105 bits (263), Expect = 1e-21, Method: Composition-based stats. Identities = 38/245 (15%), Positives = 90/245 (36%), Gaps = 17/245 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR ++ G PLI Q L L E D + S+ Sbjct: 15 RVILTRELEDIKKDKPLFEREGFKVLELPLI------QTKVLEFNLPD-EEFDYIVFQSK 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV +++ + K A+G+ TA L + + P++ E ++ L++L Sbjct: 68 KAVKIFLGKVNLKGNK-----KIVAVGKKTAEELEKLGYKADFIPEN-ESAKGLIEL--F 119 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + + + LI R GR + L EV + Y + Y E + Sbjct: 120 KRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKG--DF 177 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ S ++ ++ + L + + + + + ++ +++ ++ + + Sbjct: 178 IIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDI 237 Query: 242 LRALQ 246 ++ L+ Sbjct: 238 VKKLK 242 >UniRef50_C9M5W2 Porphyrin biosynthesis protein HemD n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W2_9BACT Length = 493 Score = 105 bits (263), Expect = 1e-21, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 77/247 (31%), Gaps = 22/247 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++VTR + L G P P A G+ + L S Sbjct: 251 LTVVVTRGASDAPRFAGTLARWGARVLVRP--SIDPRADFSSPALSDFRPGQHEWLVFTS 308 Query: 61 QHAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 H V F L Q+ D + A+G TA L L P D S L + Sbjct: 309 AHGVEFFFQWLAQKGWDVRAFAGAKIAAVGPATARELEARGLIVDLVP-DVFDSAHLAEA 367 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + A R +++ + G + Y+ + + W Sbjct: 368 LAARKTS--SAAAFRAWEATDVLSREMARSGCRLDEYPLYRNEMDGGEVGSLSADW---- 421 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V S ++ R L + A+ A++LG+Q + A A Sbjct: 422 ---VTFASPSAVRGFVRRWKAPGA-------RALCIGPTTAEEAQKLGFQTVT-ARQATF 470 Query: 239 DALLRAL 245 +++ AL Sbjct: 471 ESMTAAL 477 >UniRef50_B0C6J8 Uroporphyrinogen-III synthase n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0C6J8_ACAM1 Length = 287 Score = 105 bits (262), Expect = 2e-21, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 89/245 (36%), Gaps = 16/245 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++T P P L + + G + P IE P L L L + + S+ Sbjct: 17 RIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDHALQQLRDFSWVAFTSR 76 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + +L Q D L AIG+ A L T+ + L P++ + ++ +L Sbjct: 77 TGIQAVMLRLQQLDIPLFLLNQCHICAIGQD-ADQLQTLGVRVDLIPKESSPAGLVAELA 135 Query: 120 ELQNIAGKRALILRGNGGR--------ELIGDTLTARGAEVTFCECY-QRCAIHYDGAEE 170 ++ +I +R + R + + D L G V Y R A E Sbjct: 136 QIPDIDTRRIFVPIPQVERIPEPDIVPKFLAD-LEQLGLTVVSVPAYVTRRLEATAYAVE 194 Query: 171 AMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 + + +V + +S + L ++ E + HC + A A++LG Sbjct: 195 VEQIRQGKVDAIAFSSTAEISALLQMV---DAETLMKHCVIACFGPYTAGNAKDLGLSVD 251 Query: 231 KVADN 235 V+ + Sbjct: 252 IVSQD 256 >UniRef50_Q11DF2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chelativorans sp. BNC1 RepID=Q11DF2_MESSB Length = 232 Score = 104 bits (261), Expect = 2e-21, Method: Composition-based stats. Identities = 55/245 (22%), Positives = 83/245 (33%), Gaps = 19/245 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ-QLPQLADQLAALGESDLLFALS 60 +LVTRP P RL LG PL + P + A+ +AAL S Sbjct: 3 RVLVTRPEPGASRTAGRLAALGFEPVLLPLTKIVPLPVETWSGAENIAALA------ITS 56 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV L + P FA+G TA + ++ L + Sbjct: 57 ANAVRHTPPPLLRDLAGLPA----FAVGERTAQVAAEAGVS--VKDAGAGDADRLAERIV 110 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G + L+L G R + L A G V E Y + G E + R + Sbjct: 111 ASVQPGSKILLLCGRIRRGTLESRLAAAGLPVRAIETYDTVPVSLSGDELSTEIGDRSID 170 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V+V S L + + + +S+R+A+ I +A DA Sbjct: 171 AVLVYSAVAATILSPFVSSFLTAA------FIAISDRVAQNLPAGLGNRIHIAREPTEDA 224 Query: 241 LLRAL 245 +L L Sbjct: 225 MLSLL 229 >UniRef50_D2RRS2 Uroporphyrinogen III synthase HEM4 n=6 Tax=Halobacteriaceae RepID=D2RRS2_9EURY Length = 255 Score = 104 bits (261), Expect = 2e-21, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 75/246 (30%), Gaps = 23/246 (9%) Query: 2 SILVTRPS-PAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ V RP E + L LG P++ P+ D + S Sbjct: 14 TVAVFRPDDERLESAAALLSELGAEPVPDPMLAVEATGATPRTDA--------DYVVFTS 65 Query: 61 QHAVAFAQSQLHQQDRKW-PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + W P AIG TA AL L P+ S L+ Sbjct: 66 KTGAELVSEA------GWEPGDQTVCAIGPATADALRAEGYAVDLVPEK-FTSSGLVAAL 118 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E +AG R + R + G ++ D GA V Y+ G A+ ++ Sbjct: 119 E-DRVAGARIEVARSDHGSAVLLDGFEDAGAYVHETILYRLVRPDGSGKSAALA-AEGDL 176 Query: 180 TMVVVTSGEMLQQLWSLIPQWY----REHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 V TS + L + V+ E A+ A E G V Sbjct: 177 DAVCFTSSLTVDHFLEAAADRGVRDAALEGLAAATVGVIGEPTAETAAERGIDVDVVPKE 236 Query: 236 ADNDAL 241 A DAL Sbjct: 237 ATFDAL 242 >UniRef50_C9RPT4 Uroporphyrin-III C-methyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT4_FIBSS Length = 525 Score = 103 bits (258), Expect = 4e-21, Method: Composition-based stats. Identities = 48/266 (18%), Positives = 85/266 (31%), Gaps = 35/266 (13%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS--------------------PGQQLP 41 ++VTR + + +RL LG P+IE +L Sbjct: 263 RLVVTRAAKQSSGITARLTALGAEVIETPMIETRNVLPYCHAELPSCIANSYEYDTAELA 322 Query: 42 QLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVS 99 LAD L + D+L S + V QL + L ++G+ T L Sbjct: 323 DLAD-FEDLKDFDILAFTSTNGVESFFEQLFTAEYDVRELAGKKIASVGKITEKKLLEYG 381 Query: 100 GQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ 159 + P+D E L L R L+L+GN + + L T Y+ Sbjct: 382 IRCDYVPKD-HTGEGLGLLLREVVDDESRILLLQGNLADDTLLKLLPKA----TRWIVYE 436 Query: 160 RCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLA 219 I + + VV S ++ + L + Sbjct: 437 TLPIAELPDWKREAIASA--DAVVFASSSAVENFAQISSLSSFVSRLS----FCIGRMTE 490 Query: 220 KLARELGWQDIKVADNADNDALLRAL 245 A++ G++ + +D D+L++ + Sbjct: 491 ASAKKHGFETVT-SDETTMDSLVKKI 515 >UniRef50_B2SLZ9 Uroporphyrinogen-III synthase n=16 Tax=Xanthomonadaceae RepID=B2SLZ9_XANOP Length = 267 Score = 102 bits (256), Expect = 7e-21, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 83/235 (35%), Gaps = 7/235 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++ RPS L + G Q D L + + S Sbjct: 21 TLISLRPSGEHAPLRRAVARHGGRVLALSPWRLQ-TNDAAQARDALRQALAAPIAVFTSP 79 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV A +L R P + ++G TA AL ++ P R SE L L Sbjct: 80 AAVQAAH-RLAPLQR--PAQAHWVSVGDGTARALQACGIDTVVRPT-RMDSEG-LLALPL 134 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + ++ GGR ++ TL RGA + + YQR + + A ++ Sbjct: 135 LQAPLQAVGLITAPGGRGMLAPTLEQRGARIVRADVYQRIPLRLRASAIQALSHALPRSV 194 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + ++S E L + +P E W ++ S+R+ A G+ A+ Sbjct: 195 LALSSAEALTLVLQQLPSALIEKW-QRRPVVASSDRMLDAAHAAGFIHRMRAEGP 248 >UniRef50_Q3ACT2 Uroporphyrinogen-III synthase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=Q3ACT2_CARHZ Length = 343 Score = 102 bits (256), Expect = 7e-21, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 73/246 (29%), Gaps = 11/246 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ P +E G + PL++ + L D L S Sbjct: 102 RVLI--PRTEADE-KRECGRFGAIGIEVPLLKITYIPDERILQ---LDFSAYDWLIFTSA 155 Query: 62 HAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 H V L+ + +G TA AL PQ ++ L+L Sbjct: 156 HGVEGFFFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFSPQKFTAKDLALELTT 215 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 I K ++++GN GR + + L Y+ +A+ + Sbjct: 216 SGMIQ-KGVIVIQGNLGRPELLEILARNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLID 274 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TS + I E+ + + + + + + + Sbjct: 275 VLFFTSPSTFNNFYQFIS---DENLAKNLPHFAIGPTTYEAFLQKDIRRKYFSSEHTLEG 331 Query: 241 LLRALQ 246 L + L+ Sbjct: 332 LWQTLK 337 >UniRef50_UPI0001C35DE2 uroporphyrinogen III synthase/methyltransferase (HemD+CobA) n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE2 Length = 504 Score = 102 bits (255), Expect = 1e-20, Method: Composition-based stats. Identities = 39/247 (15%), Positives = 74/247 (29%), Gaps = 6/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + VT +L L G +E + + L + + S Sbjct: 255 RVAVTGTGLLAAKLRKSLEEAGASTECVLSLELESCRSGEAMKAAYERLADYGWIVFTSA 314 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV L + R + + A+G+ TA L P++ + L + Sbjct: 315 NAVREFFLGLLESGRDNRSVGHVKFAAVGKGTAKELLRYGFTTDYIPEEFCAA-ALARGL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G+R LI R G + L G Y E + + + Sbjct: 374 KDVVKDGERLLIPRSLKGSPELNGILDGAGIRYDDVVLYNVAERKQGEKELSEALK--KA 431 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + SG + + + L R++ + + AK E G + A + Sbjct: 432 DYLTFASGSGVDAFFENAGEDVT-ALLAGIRVVCIGDITAKKLEEHGRKADVTASRFTVE 490 Query: 240 ALLRALQ 246 + A+ Sbjct: 491 GMTEAVS 497 >UniRef50_B9MRJ5 Uroporphyrin-III C-methyltransferase n=2 Tax=Clostridia RepID=B9MRJ5_ANATD Length = 491 Score = 101 bits (253), Expect = 2e-20, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 90/247 (36%), Gaps = 19/247 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWH--FPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 I +TRP + S L +LG + ++ L +L E D+L Sbjct: 253 RICITRPKSVSRNIKSLLFSLGADVVDGCCSKLVL----HREEIDKILNSLPEYDILVFT 308 Query: 60 SQHAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 S + V L +++ + D+ AIG+ TAL+L P D S+ L+++ Sbjct: 309 SVNGVDSFFDYLTEKNIDVRNIKGDFAAIGKKTALSLQKRGFGVKYIP-DEHSSDGLIKI 367 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 E + K+ L ++ + + ++L + G EV Y Sbjct: 368 FENEVDKSKKILTVQSKNAGDYLKNSLESLGFEVDTIFAYSMEFTKNPNDAVYDS----- 422 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + V TS M + L + ++ + E K G + I +++ A + Sbjct: 423 -DIFVFTSSGMFRHFIECYGVEV----LSNKIVISIGEHTQKTLESFGIKSI-ISNEATD 476 Query: 239 DALLRAL 245 + ++ + Sbjct: 477 EGIVNKI 483 >UniRef50_C2LYB7 Uroporphyrinogen-III synthase n=1 Tax=Staphylococcus hominis SK119 RepID=C2LYB7_STAHO Length = 223 Score = 101 bits (253), Expect = 2e-20, Method: Composition-based stats. Identities = 41/221 (18%), Positives = 70/221 (31%), Gaps = 24/221 (10%) Query: 25 VAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDY 84 H P I+ + QL D L S++AV L + K Sbjct: 19 EVIHKPFIKIQSLEFDTQLLH-----DNYDWLIFSSKNAVHLFYKYLEYVNVK-----HI 68 Query: 85 FAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDT 144 +G TA + P D E LL+ L+ + LI R + T Sbjct: 69 AVVGAKTAQLCKQLGINIDFIPNDYSQ-EGLLEGLNLEKSS---ILIPSSAQARPKLQQT 124 Query: 145 LTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQ-QLWSLIPQWYRE 203 L V + Y A + E Q +V + +S ++ P+ + Sbjct: 125 LAEHN-NVVKIDLYTPIADRENIIEVINLIQHNQVEALTFSSSSAVRYYFSEAFPKHF-- 181 Query: 204 HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 + ++ A R G++ +AD ++AL+ Sbjct: 182 -----KNYYAIGQQTANSIRAYGYE-PYIADKQTSEALINT 216 >UniRef50_D1B7N0 Uroporphyrin-III C-methyltransferase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N0_THEAS Length = 494 Score = 100 bits (250), Expect = 4e-20, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 84/250 (33%), Gaps = 21/250 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 +++ V RP P G + RL LG A+ PL+E P +L LA+L +D + S Sbjct: 245 LTVAVCRPMPEGYQTARRLEALGADAFTLPLLEVRPTASREEL---LASLEGADTVVFTS 301 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + + AIG T +L + L P +R S L +L Sbjct: 302 PRGPKVFRDLVMDLRL---LRCRTVAIGEGTRRSLEEMGIGVDLMP-ERADSRSLAELLV 357 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM-RWQAREV 179 G+R L LR L + + GA Y+ E + WQ Sbjct: 358 SCVRPGERILFLRNRRCSPLPVEAVRRAGALALELPIYEMVPRGLPWRELILEHWQDTRP 417 Query: 180 TMVVVTSGEMLQQLWSLIPQ----WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 VV S + + W C AK EL + V + Sbjct: 418 HAVVFGSAALAEAFADEFGPLPAGAVPVAWGEEC---------AKRCGELFRRRGVVMAS 468 Query: 236 ADNDALLRAL 245 D D L+ AL Sbjct: 469 QDLDGLVSAL 478 >UniRef50_C8XF52 Uroporphyrinogen III synthase HEM4 n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8XF52_NAKMY Length = 263 Score = 100 bits (250), Expect = 4e-20, Method: Composition-based stats. Identities = 42/196 (21%), Positives = 65/196 (33%), Gaps = 6/196 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 +LV RP+ +LV L G LI + L + L + Sbjct: 15 RVLVPRPAERSADLVQALTAAGARPEVVELIGIAEPADTAALDLAVLGLSRGEDAWVAFT 74 Query: 60 SQHAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + D A+G TA AL L P R + L Sbjct: 75 SVNAVDAVVGRARALTVDPVIAADTRVAAVGPATARALRAAGLPVDLQPAARGSAAALAA 134 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + Q + L+ R + + + L +G +V Y+ + E A R A Sbjct: 135 VFP-QAAGDQSVLLPRSDLAPDTLPAALAGKGFQVRPVIAYRTV-VRPPEPEIARRLAAG 192 Query: 178 EVTMVVVTSGEMLQQL 193 + V+ TS +Q L Sbjct: 193 DFHAVLFTSPSTVQAL 208 >UniRef50_C3WG36 Uroporphyrinogen-III synthase n=17 Tax=Fusobacterium RepID=C3WG36_FUSMR Length = 488 Score = 100 bits (250), Expect = 4e-20, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 79/246 (32%), Gaps = 13/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR E ++ +G A P I+ L ++ ++ L L S Sbjct: 255 KVLVTRDKRQAREFSDKIEKIGGFAIELPFIKIEST--LDKIDREM--LKSYSTLLFNSP 310 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V +++ A+G T L + P++ + E L + Sbjct: 311 NGVREFMNKIEDIRDI--AHLKIGAVGSKTKELLERYKIKADFIPKEYLV-EKLAKEAIH 367 Query: 122 QNIAGKRALILRGNGGRELIGDTLTA-RGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ LI+ + L + Y+ I D E + +V Sbjct: 368 YTAVEEKILIITSDIS-PCDTKKLNSIYDRHFDKIVAYKTKKIIRDKEEVLDTLK--KVE 424 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V S + I Y + + + + ++ ++ G A D + Sbjct: 425 IVTFLSSSTVDAFMESIE--YDIESVKNIKFASIGPVTSETIKKYGLTVDFEAKVYDANG 482 Query: 241 LLRALQ 246 ++ A++ Sbjct: 483 IIEAIK 488 >UniRef50_B3T2T9 Putative Uroporphyrinogen-III synthase HemD n=1 Tax=uncultured marine crenarchaeote HF4000_ANIW93H17 RepID=B3T2T9_9ARCH Length = 273 Score = 100 bits (249), Expect = 5e-20, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 100/263 (38%), Gaps = 22/263 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 +I +TR +E + + P IE G+ + + L+AL E D + Sbjct: 10 TIAITRSKDDSQEFIDLITREKGNVLPLPTIELV-GKGEKIVDEFLSALAEGDPDYSVFM 68 Query: 60 SQHAVAFAQSQLHQQD-----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S AV+ + R A+G T AL + + PQ R S Sbjct: 69 SSKAVSLLFETAKKAGKFEELRLAVANTIVLAVGPRTKDALEKENVKVAYMPQ-RYSSVG 127 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE---A 171 + ++ N GK+ +I R + + L G +VT Y D ++ Sbjct: 128 IGEVFTKLNAVGKKVIIPRSGASTPFLKELLEKIGLDVTELYLYD-VCAFRDTSQWNEFR 186 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH----WLLHCRLLVVSERLAKLARELGW 227 + +V ++ TS ++ + ++ + + ++ L ++ + A ++L Sbjct: 187 QLFSQNKVDGIIFTSVSSVRAFFEIMQKDHDKNKLVDMLHETIVISIGPFTADELKKLNV 246 Query: 228 QDIKVAD----NADNDALLRALQ 246 +++ +AD + DA+++AL Sbjct: 247 ENV-IADVHTVSGSFDAIVKALS 268 >UniRef50_UPI000185083E uroporphyrinogen-III synthase n=1 Tax=Bacillus coahuilensis m4-4 RepID=UPI000185083E Length = 205 Score = 99 bits (248), Expect = 6e-20, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 77/192 (40%), Gaps = 5/192 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR ++ + LG A PL+ FS + + + + + +F S + Sbjct: 12 IIVTRGVEQSTSMIQAIECLGGTAHAVPLLAFSESTLEDEYLLMMEKITQFEWIFFTSHN 71 Query: 63 AVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 ++ F + +L + L + A+G TA L + + P R +E ++Q L Sbjct: 72 SIHFFRRKLKKLGISLKDLHVNIAAVGEKTAKHLRELGVEVDFLPS-RFTAEDMIQEFLL 130 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +N + LI +GN ++ + L Y+ + + + + + Sbjct: 131 ENPLAQHILIPKGNLASSILSNGLAKERISHQEWVIYKNEVPT--SSPQCLEETVKNIGS 188 Query: 182 VVVTSGEMLQQL 193 +V+ S + LQ L Sbjct: 189 IVLHS-QALQLL 199 >UniRef50_B6R6Q3 Uroporphyrinogen-III synthase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R6Q3_9RHOB Length = 236 Score = 99.1 bits (246), Expect = 1e-19, Method: Composition-based stats. Identities = 50/247 (20%), Positives = 82/247 (33%), Gaps = 16/247 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ILVTRP P ++ +L +G P++ F P +A A+ S Sbjct: 1 MKILVTRPQPQADKTAQKLVAMGHEVIVEPMLSFQPLTVNGDVAGDAKAIA------VTS 54 Query: 61 QHAVA-FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV + L + + P +++G TA A KI+ S L Sbjct: 55 AKAVEALVFNGLVDKLQHLP----LYSVGEATAKAAEASGFPKIICADGDVDS---LGRL 107 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + L +G E YQ A + +A + Sbjct: 108 IAERNQDGPVFYPAAVDRSGDLAGQLEQQGIACRMVEVYQMAAATGFSGKTRDLIEAGTL 167 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + S +Q S+ +L + L VS+R+A+ A+ G ++ A D Sbjct: 168 DCALFYSPRTIQIFLSISNLEKTTVFLNSMKALCVSKRVAEQAQSFG--EVFTAKTPSED 225 Query: 240 ALLRALQ 246 L L Sbjct: 226 GLFELLS 232 >UniRef50_Q2J3D5 Uroporphyrinogen III synthase HEM4 n=14 Tax=Bradyrhizobiaceae RepID=Q2J3D5_RHOP2 Length = 265 Score = 99.1 bits (246), Expect = 1e-19, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 83/249 (33%), Gaps = 19/249 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP P + + LR G P++ F P + + S + Sbjct: 21 LLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDDQD------TDYTGVIVTSAN 74 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A+ + Q FA+G+ TA A + ++ E L+L Sbjct: 75 ALR---AIADQPGFARLLKLPLFAVGKHTARAARDAGFKDVIV---AEGDAARLRLKVAD 128 Query: 123 NIAGKR------ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 ++ GK+ + + R+ + L G V Y+ + A + A Sbjct: 129 SVKGKKKAAGALLYLAGADLSRD-LAGELREDGFHVVMQTTYRMLPVQTLPATICDEFAA 187 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + V+ S + E L +S+ ++ + RE G + VA Sbjct: 188 NRIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQVMVARTP 247 Query: 237 DNDALLRAL 245 D AL AL Sbjct: 248 DEKALFEAL 256 >UniRef50_C8NBV8 Putative uncharacterized protein n=1 Tax=Cardiobacterium hominis ATCC 15826 RepID=C8NBV8_9GAMM Length = 243 Score = 98.8 bits (245), Expect = 1e-19, Method: Composition-based stats. Identities = 62/247 (25%), Positives = 98/247 (39%), Gaps = 27/247 (10%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L TR + +R+ LG A H PL+ + LP A A L SD+L S Sbjct: 8 TLLYTRDAAHYPAFRARIAALGGSALHLPLMT---TRVLPLSATDRAILDHSDVLVFTSA 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV Q +D+ AIG+TTA AL + + SE LL Sbjct: 65 AAVHHLIEQYPLRDQ------QTVAIGKTTAAALPS---PPTITAPAPYNSEALLA---Y 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH---YDGAEEAMRWQARE 178 G R ++ GGRE + TL + V Y+R D Sbjct: 113 WQPRGMRIALIAAPGGREQLAATL-NKNNTVHTLYPYRRTNPTAVWPDALPL-------- 163 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ + S + L L ++IPQ + + +S R+A+ A++ G+Q A++A Sbjct: 164 PDIITIASQQTLNHLLAIIPQEKLKLLKYRACIAAISARVAQYAQQQGFQQTIFAEDASE 223 Query: 239 DALLRAL 245 + A+ Sbjct: 224 TRQISAI 230 >UniRef50_Q18ES1 Uroporphyrinogen-III synthase n=6 Tax=Halobacteriaceae RepID=Q18ES1_HALWD Length = 261 Score = 98.4 bits (244), Expect = 2e-19, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 81/235 (34%), Gaps = 17/235 (7%) Query: 16 VSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQD 75 V L G P++ P +P++ D ++ + S+ V D Sbjct: 5 VELLEEYGITPIPDPMLSVEPTGTIPEI-DTVSDASPF--VVLTSKTGVEI------LAD 55 Query: 76 RKW-PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRG 134 W P + IG TA A V + P + S+ L+ Q + + +I R Sbjct: 56 AGWNPTVATLVCIGPRTAAAARDVGWTVDIIPTE-YSSQGLVDALADQ-VTDRSVIIARS 113 Query: 135 NGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLW 194 + G E + D L A GA VT Y+ G M E+ V TS ++ Sbjct: 114 DHGSETLIDGLDAAGAAVTETVLYKLVRPDGTGQSTVMAAGN-ELDAVCFTSSLTVEHFL 172 Query: 195 SLIPQ----WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 S L + + + E + A+ G + +A + L+ A+ Sbjct: 173 SAAANRELREETIMGLNNAVVGTIGEPTRETAQAHGVRVDVTPADATFEHLVEAV 227 Score = 40.2 bits (93), Expect = 0.071, Method: Composition-based stats. Identities = 20/134 (14%), Positives = 39/134 (29%), Gaps = 9/134 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 S+++ R E L+ L G L + + +AA E D + S Sbjct: 107 SVIIARSDHGSETLIDGLDAAGAAVTETVLYKLV-RPDGTGQSTVMAAGNELDAVCFTSS 165 Query: 62 HAVAFAQSQLHQQDRK-----WPRLPDYFAIGRTTALALHTVSGQKILYPQD---REISE 113 V S ++ + IG T + + P D + E Sbjct: 166 LTVEHFLSAAANRELREETIMGLNNAVVGTIGEPTRETAQAHGVRVDVTPADATFEHLVE 225 Query: 114 VLLQLPELQNIAGK 127 ++ + ++ Sbjct: 226 AVVNELQTGQLSSD 239 >UniRef50_A0B883 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=7 Tax=Archaea RepID=A0B883_METTP Length = 491 Score = 98.4 bits (244), Expect = 2e-19, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 78/247 (31%), Gaps = 15/247 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I + R + V G + P I + + +++ + S Sbjct: 247 RIAILRAEKQLDVSVRLAERYGFIPVAAPSISLRALELPHDIKERIEKTEC---VVFTSS 303 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V + + AIG TA AL + P + ++ L Sbjct: 304 NGVEIISRR--SDLVDLIQKKRVAAIGPKTAQALSERGVNVDVIPAEYSSRGLVNALGGF 361 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 K L+LR G + L + G EV Y+ D + + +A + + Sbjct: 362 -----KSVLLLRSAQGSPALLQGLRSSGIEVEDVPVYE-VKGSEDSRLDDLIRRAELIDV 415 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLH----CRLLVVSERLAKLARELGWQDIKVADNAD 237 TSG ++ L + E L ++ + A++ E G + + + Sbjct: 416 FAFTSGSTVRYLMRRSEELGMEDHLRRALDSALVVAIGPPTAEVLGEFGVRVDLIPERYT 475 Query: 238 NDALLRA 244 + +L A Sbjct: 476 FEGMLEA 482 >UniRef50_C2BTR7 Uroporphyrinogen-III synthase n=3 Tax=Mobiluncus RepID=C2BTR7_9ACTO Length = 252 Score = 98.4 bits (244), Expect = 2e-19, Method: Composition-based stats. Identities = 48/241 (19%), Positives = 81/241 (33%), Gaps = 11/241 (4%) Query: 8 PSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALG--ESDLLFALSQHAVA 65 P G+ L + L G P+ E P D + L E D + S Sbjct: 8 PRVPGDVLATGLEQAGLPVVCAPVTEKVPTPS-EDWFDPMQRLQSGEYDWVVLSSVATAT 66 Query: 66 FAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIA 125 F H A+G TA A+ G L D +E L+++ Sbjct: 67 F--LDAHYDLEDLFAQVQVAAVGSATAEAIRQFDGHVDLVGPDPACAESLVEVFPAGTGT 124 Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 L+ G +G L +G V Y+ + E T V++T Sbjct: 125 ---VLLPGAVGAAPTLGQGLNRKGYNVEKLRLYESVCLPDLPLEWETALAPGAHTYVLIT 181 Query: 186 SGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 +G + L+ + + W + + A + RELGW +V + + + ++RA Sbjct: 182 AGSVAHAAHQLLTKAGVKQWPEP---IAFGKSSATVLRELGWSAAEVCETTNTEGVVRAY 238 Query: 246 Q 246 + Sbjct: 239 E 239 >UniRef50_A9A1A3 Uroporphyrinogen III synthase HEM4 n=2 Tax=Thaumarchaeota RepID=A9A1A3_NITMS Length = 267 Score = 98.0 bits (243), Expect = 2e-19, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 90/259 (34%), Gaps = 17/259 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 +I +TR S E +S P IE + + + L ++ D + Sbjct: 6 TIAITRSSDDASEFISLAEQTNATPIALPTIELVSKGEKI-VDEFLDSVETYNPDYSVFM 64 Query: 60 SQHAVAFAQSQLHQQD-----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S AV + + ++G T +AL T + P+ S Sbjct: 65 SSKAVKLLFDTAKESGKLETLQLAIANTIVISVGPKTTIALETQGIKVNHQPEKTFSSVG 124 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEE---A 171 + +L N GK+ ++ R + + L G +V+ Y D ++ Sbjct: 125 VGELFTQLNAVGKKVIVPRSGASTPFLKELLNKIGIDVSEIHLYD-VCAFRDTSQWNGFR 183 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLL----HCRLLVVSERLAKLARELGW 227 + +V VV TS ++ + ++ + Y E+ LL ++ + + ++ Sbjct: 184 ELFSQNKVDGVVFTSASSVRGFFEIMTKDYDENSLLDNLAKLSVVSIGPFTSDELKKFKV 243 Query: 228 QDIKVADNADNDALLRALQ 246 ++ VA+ A++ Sbjct: 244 KN-TVAEVHTVAGAFEAMK 261 >UniRef50_B9YIB7 Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax='Nostoc azollae' 0708 RepID=B9YIB7_ANAAZ Length = 135 Score = 97.2 bits (241), Expect = 5e-19, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 37/98 (37%), Gaps = 2/98 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR + RL G P +E P L ++ L D L S Sbjct: 22 TILVTRSVGQSRQFSDRLTAGGATVIEMPALEIRPPSSWTPLDQAISKLSSFDWLILTSS 81 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHT 97 + V + ++L +D+ + +G TA +L Sbjct: 82 NGVEYFFNRLQTKGKDKSALKKVKVALVGAKTAQSLKN 119 Score = 47.1 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 41/113 (36%), Gaps = 1/113 (0%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 P +AGK L+ R G D LTA GA V + + + Sbjct: 13 PSTTTLAGKTILVTRSVGQSRQFSDRLTAGGATVIEMPALEIRPPSSWTPLDQAISKLSS 72 Query: 179 VTMVVVTSGEMLQQLW-SLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 +++TS ++ + L + + L ++ +V + A+ + + I Sbjct: 73 FDWLILTSSNGVEYFFNRLQTKGKDKSALKKVKVALVGAKTAQSLKNKIFSQI 125 >UniRef50_D1Z2S3 Uroporphyrinogen-III synthase n=1 Tax=Methanocella paludicola SANAE RepID=D1Z2S3_METPS Length = 261 Score = 96.4 bits (239), Expect = 7e-19, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 90/251 (35%), Gaps = 15/251 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLAALGESDLLFAL 59 + VTRP+ V LR+ G A P++E P + + ++L+A G+ D++ Sbjct: 9 RVAVTRPAKFLPAAVEYLRSKGMEAVPVPMMEMVPRKNGDVDAFLERLSA-GQVDVIILT 67 Query: 60 SQHAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 SQ+ F +L + L AIG T AL + + P SE ++ Sbjct: 68 SQNGFLFLLERLGDDVEHFLGLVEGVRVLAIGPKTKKALEAHAIWAKMVPS-TYSSEGIV 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE-EAMRWQ 175 + K +LR + G ++ L A GA V Y + + E Sbjct: 127 KEFSF---PRKHVEVLRSDHGNPVLIKGLEAGGAIVHETILYDIVPLKGEAQEAFVREAL 183 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLH----CRLLVVSERLAKLARELGWQDIK 231 A + TS + L+ L + V+ A+ RE G + Sbjct: 184 AGSIDAFTFTSTMTARSLFMTAESMGVLPELKSAMNAKAVAVIGTPTAEFLRENGVRVDV 243 Query: 232 VADNADNDALL 242 V N + ++ Sbjct: 244 VPRNFTFEEMI 254 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 95.7 bits (237), Expect = 1e-18, Method: Composition-based stats. Identities = 36/182 (19%), Positives = 73/182 (40%), Gaps = 11/182 (6%) Query: 26 AWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLH--QQDRKWPRLPD 83 A H PLI+ + + +L + + D + S++ V + L+ + D K Sbjct: 484 AIHTPLIKINKIENNKRLYTSIKEISVFDWIIFTSRYGVYYFFESLNEMKLDMKVLSAVY 543 Query: 84 YFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGD 143 ++G+ T+L L+ + + E +E L+ ++ + KR L+ R N G + + + Sbjct: 544 IASVGKATSLELNKHGFYADIE-SESESAEGLINYFKVMRLTRKRILLPRSNRGLKYLSE 602 Query: 144 TLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQ---QLWSLIPQW 200 L G EV Y + +Q +V +S + QL+ ++P Sbjct: 603 LLEQLGNEVIDIPVYTNEINDKAEKVDLSFFQK-----IVFSSPSGVNAFIQLYRMLPSG 657 Query: 201 YR 202 + Sbjct: 658 IQ 659 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uropor... 248 1e-64 UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen... 248 1e-64 UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enteroba... 245 9e-64 UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacil... 245 1e-63 UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobacu... 243 4e-63 UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacte... 239 7e-62 UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillacea... 237 2e-61 UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiob... 236 7e-61 UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uropo... 234 2e-60 UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobac... 232 7e-60 UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkali... 232 8e-60 UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methy... 230 2e-59 UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bac... 230 4e-59 UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH 230 4e-59 UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptunii... 228 2e-58 UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobac... 227 3e-58 UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomon... 227 3e-58 UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomon... 225 9e-58 UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus... 225 1e-57 UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bac... 223 4e-57 UniRef50_A7GTE4 Uroporphyrinogen III synthase HEM4 n=72 Tax=Baci... 222 8e-57 UniRef50_C9KL86 Uroporphyrinogen III synthase/methyltransferase ... 222 9e-57 UniRef50_C6D877 Uroporphyrin-III C-methyltransferase n=95 Tax=Fi... 222 1e-56 UniRef50_B3T8I0 Putative tetrapyrrole (Corrin/porphyrin) methyla... 218 2e-55 UniRef50_Q8GCA7 Uroporphyrinogen III synthase n=1 Tax=Bacillus m... 217 3e-55 UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 T... 216 7e-55 UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase ... 215 8e-55 UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=No... 215 1e-54 UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyri... 215 1e-54 UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyr... 215 1e-54 UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio... 214 2e-54 UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase ... 214 2e-54 UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase ... 214 3e-54 UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Paste... 213 4e-54 UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uropo... 213 5e-54 UniRef50_D1VCA0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Frank... 212 8e-54 UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gam... 212 9e-54 UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C... 211 2e-53 UniRef50_C2WCN0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Bacil... 211 2e-53 UniRef50_D2M0D2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacil... 211 2e-53 UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus... 210 2e-53 UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococ... 210 3e-53 UniRef50_C7N5L1 Uroporphyrin-III C-methyltransferase n=1 Tax=Sla... 209 8e-53 UniRef50_B2UQJ4 Uroporphyrin-III C-methyltransferase n=6 Tax=Bac... 208 2e-52 UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimn... 207 2e-52 UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thaue... 207 3e-52 UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shew... 206 6e-52 UniRef50_A6W5L9 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyri... 206 7e-52 UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaprote... 206 7e-52 UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Galli... 205 9e-52 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 205 1e-51 UniRef50_Q4JSX6 Uroporphyrin-III C-methyltransferase / uroporphy... 205 1e-51 UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456... 205 1e-51 UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desul... 205 1e-51 UniRef50_C1F250 Uroporphyrinogen-III synthase n=1 Tax=Acidobacte... 205 1e-51 UniRef50_Q7NL92 Uroporphyrinogen III synthase/methyltransferase ... 205 2e-51 UniRef50_A0QR19 Uroporphyrinogen-III synthase n=10 Tax=Actinomyc... 204 2e-51 UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio Re... 204 2e-51 UniRef50_C4DTF5 Uroporphyrinogen-III synthase; uroporphyrinogen-... 204 2e-51 UniRef50_C8NSF6 Uroporphyrin-III C-methyltransferase/uroporphyri... 203 3e-51 UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Alloc... 203 4e-51 UniRef50_D0WES9 Siroheme synthase n=1 Tax=Slackia exigua ATCC 70... 203 4e-51 UniRef50_A3ETN4 Uroporphyrin-III C-methyltransferase / synthase ... 203 5e-51 UniRef50_A6C1N1 Uroporphyrin-III C-methyltransferase n=1 Tax=Pla... 203 5e-51 UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cry... 203 6e-51 UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella... 202 9e-51 UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylopha... 202 1e-50 UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurel... 202 1e-50 UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marin... 201 2e-50 UniRef50_Q180R8 Porphyrin biosynthesis protein includes: uroporp... 200 3e-50 UniRef50_A6CN70 HemD n=1 Tax=Bacillus sp. SG-1 RepID=A6CN70_9BACI 200 3e-50 UniRef50_Q59294 Uroporphyrinogen-III synthase n=6 Tax=Clostridiu... 200 3e-50 UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrional... 200 3e-50 UniRef50_Q9K8G1 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus... 200 4e-50 UniRef50_A9B548 Uroporphyrinogen III synthase HEM4 n=1 Tax=Herpe... 200 4e-50 UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteo... 199 7e-50 UniRef50_A7Z7A4 HemD n=1 Tax=Bacillus amyloliquefaciens FZB42 Re... 199 7e-50 UniRef50_C1YGP0 Uroporphyrinogen-III synthase; uroporphyrinogen-... 198 1e-49 UniRef50_P21248 Uroporphyrinogen-III synthase n=4 Tax=Bacillus R... 198 2e-49 UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcu... 198 2e-49 UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marin... 198 2e-49 UniRef50_C8WIZ1 Uroporphyrin-III C-methyltransferase n=10 Tax=Ba... 198 2e-49 UniRef50_Q1INI7 Uroporphyrinogen-III synthase n=1 Tax=Candidatus... 197 2e-49 UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggi... 197 2e-49 UniRef50_Q2JFR9 Uroporphyrinogen-III synthase / uroporphyrinogen... 196 6e-49 UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanel... 196 6e-49 UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma pr... 196 7e-49 UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococ... 196 7e-49 UniRef50_C1PAG5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacil... 196 8e-49 UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pir... 195 9e-49 UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassifi... 194 2e-48 UniRef50_C1ZIN7 Uroporphyrin-III C-methyltransferase n=1 Tax=Pla... 194 2e-48 UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionell... 194 2e-48 UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia ... 194 2e-48 UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burk... 194 3e-48 UniRef50_C7P5B9 Uroporphyrinogen III synthase HEM4 n=1 Tax=Metha... 194 3e-48 UniRef50_Q1D8Z7 Uroporphyrinogen-III synthase n=2 Tax=Cystobacte... 193 5e-48 UniRef50_A9GHX2 Uroporphyrinogen-III synthase n=3 Tax=cellular o... 193 5e-48 UniRef50_B5YJZ5 Uroporphyrinogen III synthase/methyltransferase ... 192 8e-48 UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured... 192 8e-48 UniRef50_Q3B017 Uroporphyrinogen-III synthase n=19 Tax=Cyanobact... 192 1e-47 UniRef50_Q8EPM9 Uroporphyrinogen-III synthase n=1 Tax=Oceanobaci... 192 1e-47 UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolum... 191 1e-47 UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Terediniba... 191 2e-47 UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus Re... 191 2e-47 UniRef50_UPI0001972E7B uroporphyrin-III C-methyltransferase n=1 ... 190 4e-47 UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verru... 190 4e-47 UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma p... 190 4e-47 UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella ch... 190 5e-47 UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionel... 189 6e-47 UniRef50_Q5WEP6 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus... 189 6e-47 UniRef50_A9KP84 Uroporphyrin-III C-methyltransferase n=4 Tax=Clo... 188 1e-46 UniRef50_Q58401 Putative uroporphyrinogen-III synthase n=8 Tax=M... 188 1e-46 UniRef50_Q2NF31 HemD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 188 1e-46 UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia ... 188 2e-46 UniRef50_UPI000050FC32 Uroporphyrin-III C/tetrapyrrole (Corrin/P... 188 2e-46 UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uropor... 188 2e-46 UniRef50_C6HUG3 Uroporphyrin-III C-methyltransferase / synthase ... 188 2e-46 UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sacch... 187 3e-46 UniRef50_D1YA62 Uroporphyrinogen-III synthase n=2 Tax=Propioniba... 186 4e-46 UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas ... 186 5e-46 UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomo... 186 5e-46 UniRef50_B0K2L5 Uroporphyrin-III C-methyltransferase n=9 Tax=The... 186 6e-46 UniRef50_Q59335 Uroporphyrinogen-III synthase n=11 Tax=Chlorobia... 186 8e-46 UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodos... 185 1e-45 UniRef50_C9RF91 Uroporphyrinogen III synthase HEM4 n=2 Tax=Metha... 185 1e-45 UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella b... 185 2e-45 UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/... 183 3e-45 UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralston... 183 4e-45 UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomon... 183 4e-45 UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobact... 182 1e-44 UniRef50_O26268 Putative uroporphyrinogen-III synthase n=1 Tax=M... 182 1e-44 UniRef50_B2UXC3 Uroporphyrinogen III synthase/methyltransferase ... 181 1e-44 UniRef50_Q31D67 Uroporphyrinogen-III synthase n=7 Tax=Prochloroc... 181 1e-44 UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivora... 181 2e-44 UniRef50_UPI0001C42100 uroporphyrinogen-III synthase HemD n=1 Ta... 180 3e-44 UniRef50_C5EV70 Uroporphyrinogen-III methylase and Uroporphyrino... 180 4e-44 UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III... 180 5e-44 UniRef50_B2V748 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sulfu... 179 6e-44 UniRef50_B3DZQ5 Uroporphyrinogen-III methylase and Uroporphyrino... 179 9e-44 UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma p... 178 1e-43 UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/... 178 2e-43 UniRef50_O67647 Putative uncharacterized protein n=1 Tax=Aquifex... 178 2e-43 UniRef50_UPI0001C35DE2 uroporphyrinogen III synthase/methyltrans... 177 3e-43 UniRef50_B3QWI2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chlor... 176 4e-43 UniRef50_A8UVV3 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogen... 175 9e-43 UniRef50_C1AA39 Putative uroporphyrinogen-III synthase n=1 Tax=G... 175 1e-42 UniRef50_A8VZH5 PhoU family protein n=1 Tax=Bacillus selenitired... 175 2e-42 UniRef50_Q0EX10 Putative uroporphyrin-III C-methyltransferase/ur... 174 2e-42 UniRef50_C1DT10 Uroporphyrinogen-III synthase n=2 Tax=Sulfurihyd... 172 7e-42 UniRef50_A6GI22 Uroporphyrinogen III synthase/methyltransferase ... 172 8e-42 UniRef50_Q0W5T0 Uroporphyrinogen-III synthase n=1 Tax=uncultured... 171 2e-41 UniRef50_C0QQD7 Uroporphyrinogen-III synthase n=1 Tax=Persephone... 171 2e-41 UniRef50_C5V9U0 Uroporphyrinogen-III synthase n=2 Tax=Corynebact... 170 4e-41 UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio... 170 4e-41 UniRef50_C1SL66 Uroporphyrinogen-III synthase n=1 Tax=Denitrovib... 170 5e-41 UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromon... 169 6e-41 UniRef50_A5UND1 Uroporphyrinogen III synthase, HemD n=2 Tax=Meth... 169 9e-41 UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacill... 168 1e-40 UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfu... 168 1e-40 UniRef50_Q3ACT2 Uroporphyrinogen-III synthase n=1 Tax=Carboxydot... 168 1e-40 UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsie... 168 2e-40 UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chrom... 168 2e-40 UniRef50_A8UZZ5 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogen... 167 2e-40 UniRef50_C2C1P1 Uroporphyrinogen-III synthase n=1 Tax=Listeria g... 167 2e-40 UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicros... 167 3e-40 UniRef50_Q3IBM6 Uroporphyrinogen III synthase/methyltransferase ... 167 3e-40 UniRef50_B8DHJ3 Uroporphyrinogen-III synthase n=18 Tax=Listeria ... 167 3e-40 UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyr... 166 5e-40 UniRef50_A8MGE5 Uroporphyrin-III C-methyltransferase n=1 Tax=Alk... 165 9e-40 UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepI... 165 1e-39 UniRef50_C9RPT4 Uroporphyrin-III C-methyltransferase n=1 Tax=Fib... 165 2e-39 UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine ... 165 2e-39 UniRef50_A7NKU9 Uroporphyrinogen III synthase HEM4 n=2 Tax=Rosei... 163 3e-39 UniRef50_UPI0001B5826B putative uroporphyrin-III C-methyltransfe... 163 4e-39 UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepI... 163 5e-39 UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 163 5e-39 UniRef50_B6R6Q3 Uroporphyrinogen-III synthase n=1 Tax=Pseudovibr... 163 7e-39 UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Ta... 162 8e-39 UniRef50_A0B883 Uroporphyrinogen-III synthase / uroporphyrinogen... 162 8e-39 UniRef50_Q0ST17 Uroporphyrinogen-III methyltransferase/synthase ... 162 1e-38 UniRef50_Q1IWF9 Uroporphyrin-III methyltransferase and synthase ... 161 2e-38 UniRef50_D2RNT3 Uroporphyrin-III C-methyltransferase n=1 Tax=Aci... 160 4e-38 UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polyn... 160 4e-38 UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 160 5e-38 UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halot... 160 6e-38 UniRef50_C5U4M5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Metha... 160 6e-38 UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutie... 159 8e-38 UniRef50_C7M2H6 Uroporphyrin-III C-methyltransferase n=1 Tax=Aci... 159 8e-38 UniRef50_D1Y458 Porphyrin biosynthesis protein HemD n=2 Tax=Bact... 159 8e-38 UniRef50_D2RGG8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Archa... 159 9e-38 UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobact... 158 1e-37 UniRef50_C3WG36 Uroporphyrinogen-III synthase n=17 Tax=Fusobacte... 158 1e-37 UniRef50_A3CL79 Uroporphyrinogen-III synthase, putative n=1 Tax=... 158 1e-37 UniRef50_C9M5W2 Porphyrin biosynthesis protein HemD n=1 Tax=Jonq... 158 2e-37 UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseud... 157 2e-37 UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Me... 156 4e-37 UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERA... 156 4e-37 UniRef50_B9MRJ5 Uroporphyrin-III C-methyltransferase n=2 Tax=Clo... 156 5e-37 UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangi... 156 6e-37 UniRef50_B2J0U6 Uroporphyrinogen III synthase HEM4 n=6 Tax=Cyano... 156 6e-37 UniRef50_D1Z2S3 Uroporphyrinogen-III synthase n=1 Tax=Methanocel... 156 9e-37 UniRef50_D0LW22 Uroporphyrin-III C-methyltransferase n=1 Tax=Hal... 155 9e-37 UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyr... 155 9e-37 UniRef50_A9A1A3 Uroporphyrinogen III synthase HEM4 n=2 Tax=Thaum... 155 1e-36 UniRef50_P10746 Uroporphyrinogen-III synthase n=15 Tax=Theria Re... 155 1e-36 UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chlor... 155 2e-36 UniRef50_B9QSU4 Uroporphyrinogen-III synthase n=2 Tax=Labrenzia ... 155 2e-36 UniRef50_O48721 Uroporphyrinogen-III synthase, chloroplastic n=1... 155 2e-36 UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina... 155 2e-36 UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia ... 153 5e-36 UniRef50_B3T2T9 Putative Uroporphyrinogen-III synthase HemD n=1 ... 153 6e-36 UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lepto... 152 9e-36 UniRef50_A2SK65 Uroporphyrinogen-III synthase n=1 Tax=Methylibiu... 150 3e-35 UniRef50_UPI00003C04D4 PREDICTED: similar to uroporphyrinogen II... 150 4e-35 UniRef50_Q12WZ2 Uroporphyrinogen-III synthase n=4 Tax=Methanosar... 150 4e-35 UniRef50_C1EAM2 Urophorphyrin III synthase n=2 Tax=Micromonas Re... 150 4e-35 UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella... 149 5e-35 UniRef50_A5KJC6 Putative uncharacterized protein n=4 Tax=Bacteri... 149 6e-35 UniRef50_C7NCC3 Uroporphyrin-III C-methyltransferase n=4 Tax=Fus... 149 6e-35 UniRef50_Q11DF2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chela... 149 7e-35 UniRef50_C7R377 Uroporphyrinogen III synthase HEM4 n=1 Tax=Jones... 149 8e-35 UniRef50_D1JGX5 Putative uroporphyrinogen-III synthase n=1 Tax=u... 149 9e-35 UniRef50_D2LKB0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Rhodo... 148 1e-34 UniRef50_UPI0000521766 PREDICTED: similar to uroporphyrinogen II... 148 1e-34 UniRef50_C9Y9I3 Putative uncharacterized protein n=1 Tax=Curviba... 148 2e-34 UniRef50_A9CUB7 Uroporphyrinogen-III synthetase n=1 Tax=Hoeflea ... 148 2e-34 UniRef50_Q9W3B3 CG1885 n=10 Tax=Drosophila RepID=Q9W3B3_DROME 147 2e-34 UniRef50_B9DNE0 Putative uroporphyrinogen III synthase n=1 Tax=S... 147 3e-34 UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea... 146 5e-34 UniRef50_C5CSC8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Vario... 146 5e-34 UniRef50_B1HVD5 Uroporphyrinogen-III synthase n=2 Tax=Bacillacea... 146 6e-34 UniRef50_D1B7N0 Uroporphyrin-III C-methyltransferase n=1 Tax=The... 146 8e-34 UniRef50_Q2J3D5 Uroporphyrinogen III synthase HEM4 n=14 Tax=Brad... 146 9e-34 UniRef50_Q18ES1 Uroporphyrinogen-III synthase n=6 Tax=Halobacter... 145 1e-33 UniRef50_Q5GRQ8 Uroporphyrinogen-III synthase n=10 Tax=Wolbachia... 145 1e-33 UniRef50_Q2VYV0 Uroporphyrinogen-III synthase n=3 Tax=Magnetospi... 145 2e-33 UniRef50_Q2IKT0 Uroporphyrinogen-III synthase n=4 Tax=Anaeromyxo... 144 2e-33 UniRef50_A8J4K4 Uroporphyrinogen-iii synthase n=1 Tax=Chlamydomo... 144 2e-33 UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta prote... 144 3e-33 UniRef50_C0VHI0 Uroporphyrinogen-III synthase n=2 Tax=Acinetobac... 144 3e-33 UniRef50_Q6C2A4 YALI0F09449p n=1 Tax=Yarrowia lipolytica RepID=Q... 144 3e-33 UniRef50_B0C6J8 Uroporphyrinogen-III synthase n=1 Tax=Acaryochlo... 144 3e-33 UniRef50_A8SQW3 Putative uncharacterized protein n=1 Tax=Coproco... 144 3e-33 UniRef50_B7FUN6 Uroporphyrinogen-iii synthase n=1 Tax=Phaeodacty... 143 4e-33 UniRef50_C6QJ56 Uroporphyrinogen III synthase HEM4 n=1 Tax=Hypho... 143 5e-33 UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonada... 143 5e-33 UniRef50_Q2RND4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Rhodo... 143 6e-33 UniRef50_C1XV34 Uroporphyrinogen-III synthase n=2 Tax=Meiothermu... 142 9e-33 UniRef50_B0W7I4 Uroporphyrinogen iii synthase n=3 Tax=Culicidae ... 142 1e-32 Sequences not found previously or not previously below threshold: >UniRef50_B2A1G8 Uroporphyrinogen-III C-methyltransferase, uroporphyrinogen-III synthase n=27 Tax=cellular organisms RepID=B2A1G8_NATTJ Length = 516 Score = 248 bits (634), Expect = 1e-64, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 94/250 (37%), Gaps = 7/250 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL ++ LG FP I+ L + + L E + L S Sbjct: 255 NILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSV 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V ++L D AIG T +L + + PQ+ +E L+ L Sbjct: 315 NGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQE-YRAEALIDLM 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + Q +G R LI R RE++ + L +G +V Y+ D + + E+ Sbjct: 374 KEQVKSGDRVLIPRAKEAREVLPEALREQGLKVDVITAYETVKDTKDTEKVRKMLKQNEL 433 Query: 180 TMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + TS ++ ++ L + + + A ++ G + +A+ Sbjct: 434 DAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTCQQYGIEVNSIANE 493 Query: 236 ADNDALLRAL 245 L+ +L Sbjct: 494 YTIPGLVESL 503 Score = 62.9 bits (152), Expect = 8e-09, Method: Composition-based stats. Identities = 16/132 (12%), Positives = 41/132 (31%), Gaps = 1/132 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + K L+ R + ++ G + + + + Sbjct: 243 LAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKK 302 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 E +V TS ++ ++ + + L + + + + E G + V Sbjct: 303 LAEYNWLVFTSVNGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQ 362 Query: 235 NADNDALLRALQ 246 +AL+ ++ Sbjct: 363 EYRAEALIDLMK 374 >UniRef50_A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=7 Tax=cellular organisms RepID=A0LN72_SYNFM Length = 519 Score = 248 bits (633), Expect = 1e-64, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 91/246 (36%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR + L LG FP I P +L + + L D S Sbjct: 255 RIVVTRAREQASDFKGMLTELGAHCIEFPTIAIEPPPSWRELDEAIRRLASYDWAIFTSV 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V F +L + AIG TA AL + L P + +E +L Sbjct: 315 NGVRFFMERLRALGLDVRELKGVRLAAIGPKTAEALEKTGLRVDLVPSE-YRAESILDSL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ +R LI R R+++ +TL A+GA V Y+ G E A R++ E+ Sbjct: 374 GDADLRERRFLIPRAMVARDILPETLRAKGALVEVVPAYRTVIPRERGPEIAERFRKAEI 433 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS + +SL + L + + A+ A + G + + Sbjct: 434 HCLTFTSSSTVSNFFSLFDRGEILPLLEGVAIACIGPVTAQTAVKHGLKVHIMPAEYTIP 493 Query: 240 ALLRAL 245 L A+ Sbjct: 494 GLANAI 499 Score = 79.1 bits (194), Expect = 1e-13, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 40/131 (30%), Gaps = 1/131 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + + G+R ++ R LT GA + + Sbjct: 243 LNWFENRPLFGRRIVVTRAREQASDFKGMLTELGAHCIEFPTIAIEPPPSWRELDEAIRR 302 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + TS ++ + + L RL + + A+ + G + V Sbjct: 303 LASYDWAIFTSVNGVRFFMERLRALGLDVRELKGVRLAAIGPKTAEALEKTGLRVDLVPS 362 Query: 235 NADNDALLRAL 245 +++L +L Sbjct: 363 EYRAESILDSL 373 >UniRef50_P09126 Uroporphyrinogen-III synthase n=119 Tax=Enterobacteriaceae RepID=HEM4_ECOLI Length = 246 Score = 245 bits (626), Expect = 9e-64, Method: Composition-based stats. Identities = 246/246 (100%), Positives = 246/246 (100%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_C0ZAH2 Uroporphyrinogen-III synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAH2_BREBN Length = 270 Score = 245 bits (625), Expect = 1e-63, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 100/244 (40%), Gaps = 2/244 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTR ELV ++ LG A+ FPL++ P +L + + L D + S + Sbjct: 15 IMVTRARSQVRELVEQIERLGGEAYAFPLLKMMPPTDTAKLDEAITQLPAFDWVVFTSVN 74 Query: 63 AVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V F ++ + A+G TA AL + + P D ++E LL Sbjct: 75 GVRFFLERMREVGVGLEAFTGKIAAVGPKTAKALEHHGLEVAVIPSD-YVAEGLLSSLYD 133 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G+R L+ R + R+ + L G VT + Y E A + Q + + Sbjct: 134 QLLPGQRVLLPRADIARKALPKELARLGLAVTEVDVYHTVIDAEHAPEAAEKLQQGLIDI 193 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ TS + + + + WL H ++ + A A++ G VA + L Sbjct: 194 ILFTSSSTVTHFMAAMEPYASLDWLKHVQIACIGPITADTAKQNGLSVHAVASEYTVEGL 253 Query: 242 LRAL 245 L A+ Sbjct: 254 LAAI 257 Score = 71.4 bits (174), Expect = 2e-11, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 33/128 (25%), Gaps = 2/128 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A + L L LG + + A + G D++ S Sbjct: 140 RVLLPRADIARKALPKELARLGLAVTEVDVYHTVIDAEHAPEAAEKLQQGLIDIILFTSS 199 Query: 62 HAVAFAQSQLHQQD-RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + + W + IG TA + E LL Sbjct: 200 STVTHFMAAMEPYASLDWLKHVQIACIGPITADTAKQNGLSVHAVASE-YTVEGLLAAII 258 Query: 121 LQNIAGKR 128 + Sbjct: 259 ENLGGNRH 266 Score = 65.3 bits (158), Expect = 2e-09, Method: Composition-based stats. Identities = 17/123 (13%), Positives = 37/123 (30%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GK ++ R + + + G E + + Q V Sbjct: 9 PLTGKCIMVTRARSQVRELVEQIERLGGEAYAFPLLKMMPPTDTAKLDEAITQLPAFDWV 68 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 V TS ++ + + ++ V + AK G + + + + LL Sbjct: 69 VFTSVNGVRFFLERMREVGVGLEAFTGKIAAVGPKTAKALEHHGLEVAVIPSDYVAEGLL 128 Query: 243 RAL 245 +L Sbjct: 129 SSL 131 >UniRef50_D1CBT3 Uroporphyrinogen-III synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT3_THET1 Length = 266 Score = 243 bits (621), Expect = 4e-63, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 102/247 (41%), Gaps = 7/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++TRP+ LV L + G V P IE +P +L +L ALG D + S Sbjct: 18 KIVITRPNHQANSLVKLLESSGAVPILLPTIEINPNVASSELDAELNALGSYDWVVFTSV 77 Query: 62 HAVAFAQSQLHQQDRK--WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L Q + + IG +T AL + + + P D I+E LLQ Sbjct: 78 NGVKIFFDRLRQLGLEEVPLSRLKFACIGPSTKSALESYGIRVDVMP-DSYIAEALLQAL 136 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++++G+R L+ R + R ++ L A GA V Y+ + YD Sbjct: 137 LDRDVSGQRILLARADSARPVLRKGLEAAGAIVREVPIYRTIPVKYDREYLKDLLAQSN- 195 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS ++ + + + + A A+ELG + VA+ + Sbjct: 196 -AITFTSSSTVKHFLDSLGD--PSYLPQSLCVACIGPITADTAKELGLRVDVVANVYTVE 252 Query: 240 ALLRALQ 246 L++A++ Sbjct: 253 GLVKAIE 259 Score = 77.2 bits (189), Expect = 4e-13, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 41/127 (32%), Gaps = 1/127 (0%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + GK+ +I R N + L + GA + +A Sbjct: 10 IAGALIGKKIVITRPNHQANSLVKLLESSGAVPILLPTIEINPNVASSELDAELNALGSY 69 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 VV TS ++ + + Q E L + + G + + D+ Sbjct: 70 DWVVFTSVNGVKIFFDRLRQLGLEEVPLSRLKFACIGPSTKSALESYGIRVDVMPDSYIA 129 Query: 239 DALLRAL 245 +ALL+AL Sbjct: 130 EALLQAL 136 >UniRef50_D0Z0U7 Uroporphyrinogen-III synthase n=5 Tax=Photobacterium RepID=D0Z0U7_LISDA Length = 251 Score = 239 bits (610), Expect = 7e-62, Method: Composition-based stats. Identities = 116/246 (47%), Positives = 143/246 (58%), Gaps = 1/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRPSP GE+L +L +G H PL+ + G ++ L QL L D L A+S Sbjct: 1 MTILVTRPSPDGEQLAHQLCAVGLTVIHQPLLAITSGDEVDLLISQLNWLKSDDFLIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV A + L Q WP+ Y A+G TA L V+GQ +L PQ R SE LL LPE Sbjct: 61 DHAVKLAHNYLQSQGASWPKNVHYMAVGHKTAATLAKVTGQSVLMPQHRCDSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I +R LILRGNGGRELI L AR AEV +CE YQRC + DG A WQ ++V Sbjct: 121 LQQIRHRRVLILRGNGGRELIRQELIARHAEVHYCETYQRCWLPLDGTTLADSWQQQQVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGE L L L+PQ W L+C L V S+R+A A +LG+ I +A N A Sbjct: 181 KLVVTSGEQLAFLHQLVPQHN-HAWFLNCHLFVPSQRIADQASQLGFTHISTVGSASNQA 239 Query: 241 LLRALQ 246 L L Sbjct: 240 LFTFLS 245 >UniRef50_C5D5K6 Uroporphyrinogen-III synthase n=9 Tax=Bacillaceae RepID=C5D5K6_GEOSW Length = 266 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 96/245 (39%), Gaps = 5/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR + +LR G PLI SP ++ + L D L S Sbjct: 9 TVLVTRGKEQAKAFSEKLRKAGATPIEIPLISISPSSHREEIERCVRQLPNYDWLIFTSA 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F + ++ LP +G+ TA AL T P + ++E +++ + Sbjct: 69 NGVRFFFPFVKKETP----LPKVAVVGKKTAAALKTYGVSPAAIPSE-FVAEGMIEALKP 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 R L+++GN R ++ D L GA++T Y+ + + R++ + Sbjct: 124 LVKPRDRVLLVKGNLARPVLRDALINMGADITDLIVYETLMNESGKEQLLYLLRERKLDV 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS +Q ++ + L C + + + A + G D D + Sbjct: 184 ITFTSSSTVQSFIRMMEEEDIASLLSGCVIACIGPITKETAEKAGLAVHICPDEYTIDDM 243 Query: 242 LRALQ 246 ++ ++ Sbjct: 244 IKEME 248 Score = 73.0 bits (178), Expect = 8e-12, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 41/124 (33%), Gaps = 5/124 (4%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++GK L+ RG + + L GA + E Q + Sbjct: 4 PLSGKTVLVTRGKEQAKAFSEKLRKAGATPIEIPLISISPSSHREEIERCVRQLPNYDWL 63 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 + TS ++ + + + ++ VV ++ A + G + + ++ Sbjct: 64 IFTSANGVRFFFPFVKKETPLP-----KVAVVGKKTAAALKTYGVSPAAIPSEFVAEGMI 118 Query: 243 RALQ 246 AL+ Sbjct: 119 EALK 122 >UniRef50_B5ERN5 Uroporphyrinogen-III synthase n=3 Tax=Acidithiobacillus RepID=B5ERN5_ACIF5 Length = 262 Score = 236 bits (602), Expect = 7e-61, Method: Composition-based stats. Identities = 77/243 (31%), Positives = 114/243 (46%), Gaps = 2/243 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I+VTRP E+++ L G FP +E + L D L L D + S++ Sbjct: 11 IVVTRPRAQTGEMLTLLEAQGARPILFPAVEIEAPENWQSLDDALHRLVTYDWVIFSSRN 70 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AVAFA S+L ++ WP P A+GR TA AL Q L P+ R SE LL+ PEL Sbjct: 71 AVAFALSRLQSRNLSWPVGPRIAAVGRETAKALGEFGLQVDLVPR-RFSSEGLLESPELL 129 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R + G+ GREL+ TL RGA CY+R + W E+ V Sbjct: 130 DVRGQRIALFAGDQGRELLEKTLDERGAVTDEVLCYRRRLPGTNPTPLLHAWARGELDAV 189 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 VTS E+ + ++ + WL + ++ +S A+ +G +A A +L Sbjct: 190 TVTSPEIFNNFYQMVGGLG-QRWLKNTPIIAISPLTAEAVTAVGLPTPWIAPEASTAGML 248 Query: 243 RAL 245 AL Sbjct: 249 AAL 251 >UniRef50_Q2RJ27 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=23 Tax=cellular organisms RepID=Q2RJ27_MOOTA Length = 520 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 96/247 (38%), Gaps = 5/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP E L L LG +FP+I P L L A+GE D + S Sbjct: 258 RVIVTRPRAQAEGLTRSLADLGAEVINFPVIRTEPPADWHPLDTALDAIGEFDWIIFTSA 317 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + +L ++ + AIG T+ AL P++ ++E + Sbjct: 318 NGVRYFWRRLLERHQDIRSLAGIRIAAIGPATSRALKERGLLTDWQPRE-YVAEAVASGL 376 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + G+R L+ R + R + L +GAEVT Y+ + A +V Sbjct: 377 GPR-VRGRRVLLPRADIARPFLAVDLRRQGAEVTEVTAYRTVKNEENAGSLKEMLAAGKV 435 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V TS ++ L+ + + + A ARE G Q A + Sbjct: 436 AAVTFTSSSTVRAFLDLLGD-GALDLVQGIDVFCLGPVTAATAREAGLQVAATAGEYTEE 494 Query: 240 ALLRALQ 246 L+RA++ Sbjct: 495 GLVRAME 501 Score = 75.3 bits (184), Expect = 2e-12, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 44/131 (33%), Gaps = 1/131 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + + G+R ++ R E + +L GAEV + + Sbjct: 246 LAWLEDKPLFGRRVIVTRPRAQAEGLTRSLADLGAEVINFPVIRTEPPADWHPLDTALDA 305 Query: 176 AREVTMVVVTSGEMLQQLW-SLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 E ++ TS ++ W L+ + L R+ + ++ +E G Sbjct: 306 IGEFDWIIFTSANGVRYFWRRLLERHQDIRSLAGIRIAAIGPATSRALKERGLLTDWQPR 365 Query: 235 NADNDALLRAL 245 +A+ L Sbjct: 366 EYVAEAVASGL 376 >UniRef50_Q1GX91 Uroporphyrinogen-III synthase n=1 Tax=Methylobacillus flagellatus KT RepID=Q1GX91_METFK Length = 256 Score = 232 bits (593), Expect = 7e-60, Method: Composition-based stats. Identities = 85/245 (34%), Positives = 122/245 (49%), Gaps = 3/245 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I +TRP L S + G A FPLI +P Q L + D L +S + Sbjct: 9 IAITRPLDQATRLTSMIEAAGGHAIGFPLIAIAPLQDYSSFEQTLDEVTMQDWLIFISSN 68 Query: 63 AVAFAQSQLHQQDRKWP-RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV A S+L + +WP P + AIG TA L +L P+ R SE LL LP++ Sbjct: 69 AVQHAMSRLQAKLPQWPPAKPQFAAIGPVTASQLMQYGITNVLQPEHRFDSESLLALPQM 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G R +I+RG GGREL+ DTL RGAEV F ECY+R D + W ++ Sbjct: 129 QAVKGLRIMIVRGVGGRELMADTLRDRGAEVRFAECYRRINPQADAGKLQSLWHNGQLDT 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +VVTS E ++ L ++ WL + V R+A+L LG + + +A +DA+ Sbjct: 189 IVVTSSEAMRNLLAMTGS-GTAEWLRDITICVNHARIAELPSSLGLR-VLIASAPGDDAM 246 Query: 242 LRALQ 246 ++ L Sbjct: 247 MQCLS 251 >UniRef50_B8GSU7 Uroporphyrinogen-III synthase n=2 Tax=Thioalkalivibrio RepID=B8GSU7_THISH Length = 272 Score = 232 bits (592), Expect = 8e-60, Method: Composition-based stats. Identities = 83/244 (34%), Positives = 132/244 (54%), Gaps = 3/244 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ E + G V FP++E + +L + L D+ +S + Sbjct: 18 VLVTRPAHQAEVFCRMIEQAGGVPLRFPVLEILEPRDSGRLDALIDRLDAFDIAIFISPN 77 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV+ A +++H R WP A+G+ +A L + P R SE LL+ PELQ Sbjct: 78 AVSMAVNRIHA-RRPWPEHLRIGAVGQKSAQELARAGHPAHICPPRRFDSEALLEEPELQ 136 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++AGKR +I RG+GGREL+GDTL RGA V + E Y+R D + + W E+ +V Sbjct: 137 DVAGKRIVIFRGDGGRELLGDTLKERGAVVEYAEAYRRGRPDADTGKLMIHWSRGELHLV 196 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI-KVADNADNDAL 241 TS E L+ L+ ++ + R WL LLV + R+ + ARELG+ VA++ ++++ Sbjct: 197 TSTSSEGLRNLFDMVGKLGRM-WLRKTPLLVGAPRMVETARELGFNGDPWVAEDPSDESM 255 Query: 242 LRAL 245 ++A+ Sbjct: 256 MQAV 259 Score = 44.1 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 39/125 (31%), Gaps = 3/125 (2%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + G L+ R E+ + G + G +A+ + Sbjct: 9 VIGPLKGAGVLVTRPAHQAEVFCRMIEQAGGVPLRFPVLEILEPRDSGRLDALIDRLDAF 68 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD-NADN 238 + + S + ++ R W H R+ V ++ A+ G D+ Sbjct: 69 DIAIFISPNAVS--MAVNRIHARRPWPEHLRIGAVGQKSAQELARAGHPAHICPPRRFDS 126 Query: 239 DALLR 243 +ALL Sbjct: 127 EALLE 131 >UniRef50_C6X7P0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methylophilaceae RepID=C6X7P0_METSD Length = 267 Score = 230 bits (588), Expect = 2e-59, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 126/246 (51%), Gaps = 2/246 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 +S+ +TRP L + G + FPLIE +P QL LG+ D +S Sbjct: 14 LSVAITRPLDQATRLSRLIVEAGGTPYGFPLIEIAPLADYSAFDAQLHELGKYDWTIFIS 73 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV A ++ + P + AIG TA L ++ +L PQ R SE LL LPE Sbjct: 74 SNAVQNAIPRMLNLVGQPPATLRHAAIGPVTAAELTSLGIGPVLTPQGRYDSESLLALPE 133 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + G+R LI RG GGREL+ ++L ARGA V F ECY+R RWQ +++ Sbjct: 134 MQQVKGQRFLIFRGVGGRELLAESLRARGATVDFAECYRRINPQTSAEPLEQRWQQQQLD 193 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS E ++ L ++ + W+ L V R+A+L ELG + VA+ +DA Sbjct: 194 AVVVTSSEAMRHLLNMT-NNGQHAWIRDVTLCVNHARIAELPIELGL-HVIVAEAPGDDA 251 Query: 241 LLRALQ 246 +L+ L Sbjct: 252 MLQCLN 257 >UniRef50_D2L438 Uroporphyrin-III C-methyltransferase n=2 Tax=Bacteria RepID=D2L438_9DELT Length = 514 Score = 230 bits (586), Expect = 4e-59, Method: Composition-based stats. Identities = 56/245 (22%), Positives = 96/245 (39%), Gaps = 4/245 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTR +LV L G + FP IE +P + + L + D + S + Sbjct: 255 VVVTRSREQASDLVRLLAEEGACCYEFPAIEIAPLADTTPVRQAASRLYDYDWVIFTSVN 314 Query: 63 AVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V +++ AIG TA AL + + P +R ++E +++ Sbjct: 315 GVKCFFAEVDALGLDARAFAGIRIAAIGPATAEALASKGLKADFLP-ERFVAESVVEGLL 373 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 IA +R LI R R+++ + L GA+V+ Y + D E +A E+ Sbjct: 374 ALGIADRRVLIPRAREARDVLPEKLAEAGADVSVLPVYDTRPVDQDPQEILEAIRAGEIR 433 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V TS ++ ++ IP + + V+ AK E G +A A Sbjct: 434 YVTFTSSSTVKNFFAKIPPAALQAA-GTVKTAVIGPITAKTLAEYGLSADVMAAAYTVPA 492 Query: 241 LLRAL 245 L A+ Sbjct: 493 LAEAI 497 Score = 76.4 bits (187), Expect = 8e-13, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 35/119 (29%), Gaps = 1/119 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A + L +L G P+ + P Q PQ + GE + S Sbjct: 381 RVLIPRAREARDVLPEKLAEAGADVSVLPVYDTRPVDQDPQEILEAIRAGEIRYVTFTSS 440 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V +++ + IG TA L + L + Sbjct: 441 STVKNFFAKIPPAALQAAGTVKTAVIGPITAKTLAEYGLSADVMAA-AYTVPALAEAII 498 Score = 68.7 bits (167), Expect = 2e-10, Method: Composition-based stats. Identities = 19/185 (10%), Positives = 51/185 (27%), Gaps = 14/185 (7%) Query: 69 SQLHQQDRKWPRLPDYFAIGRTTA-LALHTVSGQKILYPQDREISEVLLQLPEL------ 121 + L + + T A P I ++ L E Sbjct: 194 AALVRWGTTCRHKSLVATV--ATMPEAAARHGF----APPSLFIVGGVVSLHETLSWYEH 247 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + + G+ ++ R + L GA + + + + Sbjct: 248 RPLLGQGVVVTRSREQASDLVRLLAEEGACCYEFPAIEIAPLADTTPVRQAASRLYDYDW 307 Query: 182 VVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V+ TS ++ ++ + + R+ + A+ G + + + ++ Sbjct: 308 VIFTSVNGVKCFFAEVDALGLDARAFAGIRIAAIGPATAEALASKGLKADFLPERFVAES 367 Query: 241 LLRAL 245 ++ L Sbjct: 368 VVEGL 372 >UniRef50_C0Q9U3 HemD n=6 Tax=Deltaproteobacteria RepID=C0Q9U3_DESAH Length = 513 Score = 230 bits (586), Expect = 4e-59, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 92/246 (37%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTR ELV L LG P I+ P + L + + L + D + S Sbjct: 258 TIVVTRARVQASELVGSLSALGARCIEIPTIQVVPPRDPAPLVNAVKNLSDFDWVVFTSV 317 Query: 62 HAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V L Q D + + IG T L + P+ ++E +++ Sbjct: 318 NGVKLFFKTLYGEQMDVRALGGLKFACIGPATKAELFVHGIVSDILPK-TYMAESVVEAF 376 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 I GKR L+ R R ++ + L GA VT Y+ A H D AE A +V Sbjct: 377 SNVEIQGKRVLLPRAKQARTILPEELDKLGARVTEVTAYETIAEHLDEAELARLVAESKV 436 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V TS ++ L+ + A+ A LG + VA Sbjct: 437 DIVTFTSSSTVENFKRLVMDKKVLEMGPEVIAACIGPITAETAASLGIRPDIVATEFTIP 496 Query: 240 ALLRAL 245 L+ A+ Sbjct: 497 GLVDAI 502 Score = 71.4 bits (174), Expect = 3e-11, Method: Composition-based stats. Identities = 17/129 (13%), Positives = 36/129 (27%), Gaps = 1/129 (0%) Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 E + + GK ++ R + +L+A GA Q Sbjct: 247 NWFESRPLLGKTIVVTRARVQASELVGSLSALGARCIEIPTIQVVPPRDPAPLVNAVKNL 306 Query: 177 REVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + VV TS ++ + L + L + + G + Sbjct: 307 SDFDWVVFTSVNGVKLFFKTLYGEQMDVRALGGLKFACIGPATKAELFVHGIVSDILPKT 366 Query: 236 ADNDALLRA 244 ++++ A Sbjct: 367 YMAESVVEA 375 >UniRef50_Q2BL64 Uroporphyrinogen-III synthetase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BL64_9GAMM Length = 260 Score = 228 bits (581), Expect = 2e-58, Method: Composition-based stats. Identities = 76/252 (30%), Positives = 125/252 (49%), Gaps = 8/252 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ----LADQLAALGESDLL 56 + +LVTRP+ + L L G FPL++ +P L Q+ L + Sbjct: 8 LRVLVTRPAHQADTLYELLLQQGADPVRFPLLQITPVTSADSGFHLLKQQIIDLDLFQHI 67 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +S +AV + Q + P + AIG+ +A L+ P SE LL Sbjct: 68 IFISPNAVELGYEWIDQYWPQLPLGVQWLAIGKQSAARLNNYGIDAYHSPL-GYDSEALL 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 P LQ IAG + LI+RG GGRE + + L ARGAEV++ E Y+R + Y E + + Sbjct: 127 NSPALQKIAGDKVLIMRGEGGRETLAEELRARGAEVSYAELYRRESPCYSAKEISDALLS 186 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYRE---HWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + + ++++SG L+ L +L+ +E LL+C L+V S+R+ + A+ +G+ I A Sbjct: 187 KHLDAILISSGAGLKNLITLLSSTGKELSTDSLLNCHLIVPSDRIKQEAQGVGFNRITTA 246 Query: 234 DNADNDALLRAL 245 D+ +++ AL Sbjct: 247 SGPDDRSMIAAL 258 Score = 50.2 bits (119), Expect = 6e-05, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 49/133 (36%), Gaps = 9/133 (6%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + G R L+ R + + + L +GA+ Q + + + + + Sbjct: 2 ADKLNGLRVLVTRPAHQADTLYELLLQQGADPVRFPLLQITPVTSADSGF-HLLKQQIID 60 Query: 181 M-----VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + ++ S ++ + I Q++ + L + L + ++ A G Sbjct: 61 LDLFQHIIFISPNAVELGYEWIDQYWPQLPL-GVQWLAIGKQSAARLNNYGIDAYHSPLG 119 Query: 236 ADNDALLR--ALQ 246 D++ALL ALQ Sbjct: 120 YDSEALLNSPALQ 132 >UniRef50_Q9L6Q3 Uroporphyrinogen-III synthase n=47 Tax=Enterobacteriaceae RepID=HEM4_SALTY Length = 246 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 204/246 (82%), Positives = 217/246 (88%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE LVSRLR LGQVAW FPLIEF G++LP LAD+LA L E+DL+FALS Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAVAFA +QL + R WP P YFAIGRTTALALHTVSG I YP DREISE LLQLPE Sbjct: 61 QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNIAGKRALILRGNGGREL+G+TLTARGAEV+FCECYQRCA HYDGAEEAMRW R VT Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTSGEMLQ+LWSL PQWYREHWLL CRLLVVSERLA LARELGWQDIKVADNADNDA Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA 240 Query: 241 LLRALQ 246 LLRALQ Sbjct: 241 LLRALQ 246 >UniRef50_C6MCU1 Uroporphyrinogen-III synthase n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MCU1_9PROT Length = 261 Score = 227 bits (578), Expect = 3e-58, Method: Composition-based stats. Identities = 79/245 (32%), Positives = 118/245 (48%), Gaps = 2/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ILVTRP L + G P++E + + L D + L E D +S Sbjct: 10 INILVTRPLHQSTFLAENIHASGGKPILLPVLEITDVTDITPLLDLINRLDEFDWAVFVS 69 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L + R P A+G+ TA L ++L P + SE LL+ E Sbjct: 70 PNAVIKSMD-LITKQRALPPDLKIAAVGKGTADTLRRYGVNRVLIPIEHFDSEALLKSEE 128 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN+ K +I RGNGGR L+GDTL RGA + + ECY R D A W ++ Sbjct: 129 LQNMTEKHVVIFRGNGGRALLGDTLAQRGAHIEYAECYLRRKPEIDSAPLLAAWSQGKIH 188 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E L L+ +I ++ L + +R+A+ ARELG + I A ++ Sbjct: 189 AVIITSSEGLHNLFDIIGTLGQQ-LLKTTPIFTAHDRIAQAARELGLKKIVKVPYAGDEG 247 Query: 241 LLRAL 245 LL+ L Sbjct: 248 LLKGL 252 >UniRef50_Q0AH88 Uroporphyrinogen-III synthase n=3 Tax=Nitrosomonadaceae RepID=Q0AH88_NITEC Length = 260 Score = 225 bits (574), Expect = 9e-58, Method: Composition-based stats. Identities = 82/244 (33%), Positives = 123/244 (50%), Gaps = 5/244 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 IL+TRP L +R++ LG W FP++E S + L D +A L + DL +S + Sbjct: 11 ILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSPN 70 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV +H + R+WP +G+ +A AL ++ P+D SE LL++P+LQ Sbjct: 71 AVERVMPLVHAE-RRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQLQ 129 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GKR +I RGNGGR+L+GDTL RGA V + ECY+R D W + V Sbjct: 130 IMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKYWHDNGIQAV 189 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD---NADND 239 V++S E L L+ +I + ++ L + +R+ ARELG + I Sbjct: 190 VISSSEGLDNLFDMIGKTGQQ-LLRATAVFTAHDRIECKARELGIRKIYRTPLGDEGTVQ 248 Query: 240 ALLR 243 LL Sbjct: 249 GLLE 252 >UniRef50_C4K4E4 Uroporphyrinogen III synthase n=1 Tax=Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) RepID=C4K4E4_HAMD5 Length = 248 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 119/245 (48%), Positives = 167/245 (68%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRPSP GEELV ++ G A+H+PLIEFS G+ L +L+ ++ + E D++F +S Sbjct: 1 MVVLVTRPSPMGEELVQFIQAHGHTAYHYPLIEFSQGRDLMELSQRITQMREEDMIFVVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A+ + S WP Y+AIGR TA A ++ KI YP ++E SE LL L Sbjct: 61 KTAIDYLASFFKNNPLSWPPSIFYYAIGRNTAQAWQKINPFKIRYPLNQETSEGLLALAN 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I K ALILRGNGGREL+GD L RGA++ +CECYQR +HYDGA+++++WQ +V Sbjct: 121 LQFINKKTALILRGNGGRELLGDRLKKRGAQIIYCECYQRHPVHYDGAQKSIQWQRLKVD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTS EML ++++L+P+ R WL+ RL+VVS RLA +A LGW I++A+NA N++ Sbjct: 181 TVVVTSEEMLHRIYALVPEEARFAWLIKSRLIVVSARLANIATHLGWHHIQIAENASNES 240 Query: 241 LLRAL 245 LL + Sbjct: 241 LLHTV 245 >UniRef50_UPI0001C4214B uroporphyrinogen-III synthase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C4214B Length = 262 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 50/244 (20%), Positives = 93/244 (38%), Gaps = 3/244 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTR E ++++ G ++ PL+ F P + QL + + E D L S + Sbjct: 11 VLVTRAKDQAEPFINQIEEAGGISHIIPLLLFQPVKSD-QLEKAITYINEFDWLVFTSAN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V F + ++ +G T L + L P DR ++E L Sbjct: 70 GVRFFLEEFKKRHLPSSLKARIAVVGEKTEAVLDEYGLKADLLP-DRYVAEDLAVTLTTH 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE-VTM 181 AG++ L+ RGN GR L+ L G EV+ Y+ + ++ + + + Sbjct: 129 ITAGEKILMPRGNLGRTLLPKELEKAGIEVSDLTIYETVCPPEAKDQFRAFIKSGQAIDV 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS ++ ++ + E ++ + K A E A + L Sbjct: 189 ITFTSSSAVRHFAQVLLELRIEEPFKDAKIACIGPIAEKTATEYHLNVDITASTYTIEGL 248 Query: 242 LRAL 245 + A+ Sbjct: 249 IEAI 252 Score = 66.4 bits (161), Expect = 9e-10, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 34/131 (25%), Gaps = 5/131 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLI--EFSPGQQLPQLADQLAALGESDLLFAL 59 IL+ R + L L G I P + Q + + D++ Sbjct: 134 KILMPRGNLGRTLLPKELEKAGIEVSDL-TIYETVCPPEAKDQFRAFIKSGQAIDVITFT 192 Query: 60 SQHAVAFAQSQLHQQDRKWP-RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 S AV L + + P + IG + E L++ Sbjct: 193 SSSAVRHFAQVLLELRIEEPFKDAKIACIGPIAEKTATEYHLNVDITAS-TYTIEGLIEA 251 Query: 119 PELQNIAGKRA 129 K+ Sbjct: 252 IITYYKEAKKV 262 Score = 57.2 bits (137), Expect = 5e-07, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 43/122 (35%), Gaps = 2/122 (1%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 ++GK L+ R E + + G + D E+A+ + E +V Sbjct: 6 LSGKHVLVTRAKDQAEPFINQIEEAGGISHIIPLLLFQPVKSDQLEKAITYIN-EFDWLV 64 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 TS ++ + + L R+ VV E+ + E G + + D + L Sbjct: 65 FTSANGVRFFLEEFKKRHLPSSLK-ARIAVVGEKTEAVLDEYGLKADLLPDRYVAEDLAV 123 Query: 244 AL 245 L Sbjct: 124 TL 125 >UniRef50_A7GTE4 Uroporphyrinogen III synthase HEM4 n=72 Tax=Bacillus cereus group RepID=A7GTE4_BACCN Length = 252 Score = 222 bits (567), Expect = 8e-57, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 88/245 (35%), Gaps = 6/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR ++ + +R + PL+ G +L L D + S+ Sbjct: 8 KVLVTRARHQAGQMSAAVRKESGIPMEIPLLRM-DGVSQEKLQSVAKQLHVYDWIIFTSK 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F +HQ K P A+G TA L Q P ++E Sbjct: 67 NGVRFFLEAIHQ---KLPPAVKIAAVGIKTAQELEARGYQVHFVPT-AFVAETFAMEFVQ 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +R L +GN R++I L V Y+ + Q+ ++ + Sbjct: 123 TLNGTERILFPKGNLARDVISVKLREAHILVEELVVYETKLNDEKKEDLIAALQSNQIDV 182 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS + L+ W+ C + + K AR+ ++++ V + ++L Sbjct: 183 ITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKY-FKNVLVPEEYTIESL 241 Query: 242 LRALQ 246 ++ + Sbjct: 242 IQCIS 246 >UniRef50_C9KL86 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL86_9FIRM Length = 508 Score = 222 bits (566), Expect = 9e-57, Method: Composition-based stats. Identities = 56/251 (22%), Positives = 93/251 (37%), Gaps = 10/251 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEF-SPGQQLPQLADQLAALGESDLLFALS 60 ++LVTR +L + L LG P I P + +A L L S Sbjct: 258 TVLVTRARSQASKLTACLEELGARVIEKPAIAIAVPDDGYAAVDAAIAKLDSYQWLIFTS 317 Query: 61 QHAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V +L + L AIG+TTA L + + PQ+ +E +L+ Sbjct: 318 TNGVERFMQRLFAAGKDVRALGYAKVAAIGQTTAKKLQSYGICADVVPQE-FRAEGILES 376 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ--- 175 + + + L+ R RE++ + L +GAEV YQ E A + Sbjct: 377 LKGKLPPHAKILLPRAAVAREILPEKLREQGAEVDVVPVYQTVMAETSEEERAALREELE 436 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + V TS + L L+ L + + A+ AR+ G + VA Sbjct: 437 NGAIDFVTFTSSSTVVNLVKLLGGIEP---LKGVKTACIGPVTAETARKHGIEPTIVASR 493 Query: 236 ADNDALLRALQ 246 + L+ A++ Sbjct: 494 YTIEGLVEAMR 504 Score = 66.8 bits (162), Expect = 7e-10, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 39/123 (31%), Gaps = 2/123 (1%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDGAEEAMRWQAREVTMVVV 184 GK L+ R + L GA V A +A + ++ Sbjct: 256 GKTVLVTRARSQASKLTACLEELGARVIEKPAIAIAVPDDGYAAVDAAIAKLDSYQWLIF 315 Query: 185 TSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 TS +++ L L + ++ + + AK + G V + +L Sbjct: 316 TSTNGVERFMQRLFAAGKDVRALGYAKVAAIGQTTAKKLQSYGICADVVPQEFRAEGILE 375 Query: 244 ALQ 246 +L+ Sbjct: 376 SLK 378 >UniRef50_C6D877 Uroporphyrin-III C-methyltransferase n=95 Tax=Firmicutes RepID=C6D877_PAESJ Length = 520 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 95/252 (37%), Gaps = 9/252 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ---LADQLAALGESDLLFA 58 +LVTR +L R+ LG P+IE + + LA + + Sbjct: 256 RVLVTRARAQASDLADRIEELGGEPCELPVIETREPRDEAAVEGIRTALAGAESYNWIMF 315 Query: 59 LSQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 S + V + + L + + R A+G TA AL P +E LL Sbjct: 316 TSVNGVEYFFNWLDRFNVDIRRFHAARIAAVGPRTAEALRKRGLIADQLPAK-FQAEGLL 374 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + E + G++ L+ RG+ RE++ L A+G + Y+ + + Sbjct: 375 EQLEGELRPGEKVLLPRGDLAREILPRELKAKGLVPVELDVYETVIADSQDEQAFEWIRN 434 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWY---REHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 RE+ + TS + L L+ + L ++ + +K A E G Sbjct: 435 REIHAITFTSSSTVTNLLELLRRNGFEDPVAQLAGIDVVSIGPVTSKTASEAGLSVTLEP 494 Query: 234 DNADNDALLRAL 245 +NA +AL+ AL Sbjct: 495 ENATIEALVEAL 506 Score = 68.3 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 46/135 (34%), Gaps = 4/135 (2%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMR 173 L+ E + + G R L+ R + D + G E + + Sbjct: 244 LKWYEKKPLFGVRVLVTRARAQASDLADRIEELGGEPCELPVIETREPRDEAAVEGIRTA 303 Query: 174 WQARE-VTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIK 231 E ++ TS ++ ++ + ++ + R+ V R A+ R+ G + Sbjct: 304 LAGAESYNWIMFTSVNGVEYFFNWLDRFNVDIRRFHAARIAAVGPRTAEALRKRGLIADQ 363 Query: 232 VADNADNDALLRALQ 246 + + LL L+ Sbjct: 364 LPAKFQAEGLLEQLE 378 Score = 52.5 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 40/130 (30%), Gaps = 5/130 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A E L L+ G V + E + A + E + S Sbjct: 386 KVLLPRGDLAREILPRELKAKGLVPVELDVYETVIADSQDEQAFEWIRNREIHAITFTSS 445 Query: 62 HAVAFAQSQLHQQDRKWP----RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 V L + + P D +IG T+ L P++ E L++ Sbjct: 446 STVTNLLELLRRNGFEDPVAQLAGIDVVSIGPVTSKTASEAGLSVTLEPENA-TIEALVE 504 Query: 118 LPELQNIAGK 127 I + Sbjct: 505 ALVQHQITKR 514 >UniRef50_B3T8I0 Putative tetrapyrrole (Corrin/porphyrin) methylase n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8I0_9ZZZZ Length = 510 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 87/246 (35%), Gaps = 6/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR L + L G P I+ P + +L L + + + S Sbjct: 255 RVLVTRSRSQASRLCTLLEQAGASTVELPTIQIGPLEDFSELDATLKNIADYQWVIFASA 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + Q + AIG TTA AL P +S V+L+ Sbjct: 315 NAVESVFDRFESQGKDARALAGMTVGAIGPTTAQALSRWGITADFVPSRP-VSAVVLKEL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 ++ L+ + GR+ + LT GA+V Y+ + + V Sbjct: 374 SGRDWKDVSVLLPSADIGRDELEKGLTNLGAKVNRLAAYRNVPVEGVSGLAKKAFVDG-V 432 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V TS ++ L ++ L + + + ARELG Q A + Sbjct: 433 DIVTFTSSSTVRNLVEMLD--GDRAALETSFIACIGPVTSATARELGLQVDLEATEHTVE 490 Query: 240 ALLRAL 245 L+ AL Sbjct: 491 GLVDAL 496 Score = 67.6 bits (164), Expect = 4e-10, Method: Composition-based stats. Identities = 17/122 (13%), Positives = 35/122 (28%), Gaps = 1/122 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L + + + GKR L+ R + L GA Q + +A Sbjct: 243 LAWFDKRALFGKRVLVTRSRSQASRLCTLLEQAGASTVELPTIQIGPLEDFSELDATLKN 302 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V+ S ++ ++ ++ L + + A+ G V Sbjct: 303 IADYQWVIFASANAVESVFDRFESQGKDARALAGMTVGAIGPTTAQALSRWGITADFVPS 362 Query: 235 NA 236 Sbjct: 363 RP 364 >UniRef50_Q8GCA7 Uroporphyrinogen III synthase n=1 Tax=Bacillus megaterium RepID=Q8GCA7_BACME Length = 257 Score = 217 bits (553), Expect = 3e-55, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 97/247 (39%), Gaps = 8/247 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+TR + ++++ LG + P++ F+ ++ D L ++ D + SQ Sbjct: 11 KVLITREAKQAHSFAAQIKKLGGIPLSLPVLTFARSNNEKEVEDVLLSIDCFDWIVFTSQ 70 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + ++F L + + W L A+G TA L L P++ ++E LL+ Sbjct: 71 NGISFFFEWLKELNISWSALKRLKVAAVGEKTAKLLEKHDVNVQLVPKE-YVAESLLESL 129 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + +R L++RG R ++ D L EVT YQ D + + Sbjct: 130 KANVSHHERVLLVRGQLARSVLKDGLKE--CEVTDLVVYQTIRN-QDSERLVKQHVETGI 186 Query: 180 TMVVVTSGEMLQQLWSLIPQ-WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + TS ++ + + +++ + ++ A E G + V + Sbjct: 187 DAITFTSSSTVRFFVESVKDIPNWLELINRTKVVCIGPITSQTASEYGIKH-LVPNTYTI 245 Query: 239 DALLRAL 245 + ++ L Sbjct: 246 NGMIDML 252 Score = 59.9 bits (144), Expect = 8e-08, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 37/122 (30%), Gaps = 3/122 (2%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVT 185 K+ LI R + G A + E + +V T Sbjct: 10 KKVLITREAKQAHSFAAQIKKLGGIPLSLPV-LTFARSNNEKEVEDVLLSIDCFDWIVFT 68 Query: 186 SGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 S + + + + L ++ V E+ AKL + V ++LL + Sbjct: 69 SQNGISFFFEWLKELNISWSALKRLKVAAVGEKTAKLLEKHDVNVQLVPKEYVAESLLES 128 Query: 245 LQ 246 L+ Sbjct: 129 LK 130 >UniRef50_A6F8Y8 Hypothetical uroporphyrinogen III synthase n=1 Tax=Moritella sp. PE36 RepID=A6F8Y8_9GAMM Length = 255 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 92/248 (37%), Positives = 137/248 (55%), Gaps = 4/248 (1%) Query: 1 MSI--LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 M I L+TRP GE+L ++ A P I+ S GQQ +++ LA L D + A Sbjct: 1 MKIRALITRPRVKGEQLARQIEAADGAALCCPFIDISAGQQFTKVSSLLAELQPDDYIIA 60 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S +AV +A + L +R WP+ +Y A+G TTAL+ P D SE +L+L Sbjct: 61 ISDNAVNYANTSLINANRTWPQQINYIAVGPTTALSWQKYGINHAQIP-DTHDSEGVLKL 119 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 ++ K+ +ILRGNGGRE + + LT R A VT+CE YQR A YD +WQ Sbjct: 120 LANASVEHKKIVILRGNGGRETLAEDLTKRTANVTYCEVYQRTAPDYDPDMLINKWQQFA 179 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + V++TSGE+L L IP + W+L+ +V S+R+A LA LG + + +A A N Sbjct: 180 INSVIITSGEILGNLIKTIP-YTALPWILNLHFIVPSQRIAALAHTLGIEHVTIATGASN 238 Query: 239 DALLRALQ 246 ++L A++ Sbjct: 239 NSLFNAIK 246 >UniRef50_B0C0D5 Uroporphyrinogen III synthase/methyltransferase n=12 Tax=Cyanobacteria RepID=B0C0D5_ACAM1 Length = 542 Score = 215 bits (549), Expect = 8e-55, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 96/251 (38%), Gaps = 8/251 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR + L ++G P +E P L +A+L D L S Sbjct: 285 TILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPSSWKALDGAIASLDRFDWLILTSA 344 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L L +GR TA L + P + +++ L++ Sbjct: 345 NGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKADYIPPN-FVADALVEHF 403 Query: 120 ELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + G+ L R GGR+++ LT +GA V YQ + + + Sbjct: 404 PGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQT 463 Query: 179 VTMVVVTSGEMLQQLWSLIPQW----YREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 V +V S + ++ + L+ Q + WL ++ + + + +EL + A+ Sbjct: 464 VDIVTFASSKTVRYFYQLLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAE 523 Query: 235 NADNDALLRAL 245 D L +++ Sbjct: 524 EYTLDGLTQSI 534 Score = 74.9 bits (183), Expect = 2e-12, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 46/138 (33%), Gaps = 1/138 (0%) Query: 107 QDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD 166 + S L +AGK L+ R + +L + GA V + Sbjct: 264 DSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPSSW 323 Query: 167 GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLAREL 225 A + +++TS + + + + L ++ VV + AK + Sbjct: 324 KALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQ 383 Query: 226 GWQDIKVADNADNDALLR 243 G + + N DAL+ Sbjct: 384 GLKADYIPPNFVADALVE 401 >UniRef50_UPI0001C15AC8 hypothetical protein CRD_00318 n=2 Tax=Nostocaceae RepID=UPI0001C15AC8 Length = 274 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 91/255 (35%), Gaps = 13/255 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR EL + LG P +E P L + L D L S Sbjct: 14 TILVTRAVGQSSELSHGITNLGARVIELPALEIGPPSSWRSLDQSILELSTFDWLVFTST 73 Query: 62 HAVAFAQSQLH-------QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 + V +++ R+ A+G TA +L + P D + Sbjct: 74 NGVESFFARMALQYKNQQALIRRAINRTKIAAVGEKTAQSLKMHQIEPDFIPPDFIADSL 133 Query: 115 LLQLPELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 + PE N+AGK+ L R GGR+++ LT +GA+V Y+ Sbjct: 134 VNNFPE--NLAGKKILFPRVESGGRDILVKELTQKGAQVVEVPAYESLCPQSIPTTAQQA 191 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQDI 230 V ++ S + ++ L+ + L + + + +K +L + Sbjct: 192 LINHSVDVITFASSKTVKFFCVLLENNLPQKAEQYLNKSAIASIGPQTSKTCIDLLGRVD 251 Query: 231 KVADNADNDALLRAL 245 A D L++A+ Sbjct: 252 ITAQKHTIDGLIKAI 266 Score = 68.3 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 18/131 (13%), Positives = 45/131 (34%), Gaps = 6/131 (4%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + ++GK L+ R G + +T GA V + + + + Sbjct: 5 IPITPLSGKTILVTRAVGQSSELSHGITNLGARVIELPALEIGPPSSWRSLDQSILELST 64 Query: 179 VTMVVVTSGEMLQQLWSLIP------QWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 +V TS ++ ++ + Q + ++ V E+ A+ + + + Sbjct: 65 FDWLVFTSTNGVESFFARMALQYKNQQALIRRAINRTKIAAVGEKTAQSLKMHQIEPDFI 124 Query: 233 ADNADNDALLR 243 + D+L+ Sbjct: 125 PPDFIADSLVN 135 >UniRef50_Q2JNU8 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=2 Tax=Synechococcus RepID=Q2JNU8_SYNJB Length = 500 Score = 215 bits (547), Expect = 1e-54, Method: Composition-based stats. Identities = 62/249 (24%), Positives = 96/249 (38%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR L+ G P + P L +A LG+ + L S Sbjct: 246 TVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTSA 305 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +LH+Q R L +G TA L L PQ+ ++E LLQ+ Sbjct: 306 NGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQE-FVAEALLQVW 364 Query: 120 ELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + I+G+R L R GGRE + L RGAEV YQ + +A + Sbjct: 365 -PEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEALKAHQ 423 Query: 179 VTMVVVTSGEMLQQLWSLIPQW--YREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 V ++ S + +Q LI Q E W ++ + + A + + A Sbjct: 424 VDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAAQEY 483 Query: 237 DNDALLRAL 245 + L+ AL Sbjct: 484 TLEGLVEAL 492 Score = 66.4 bits (161), Expect = 7e-10, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 44/118 (37%), Gaps = 1/118 (0%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTS 186 K L+ R G + L A+GA V +A + + +++TS Sbjct: 245 KTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTS 304 Query: 187 GEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 +Q + + + R+ L ++ VV + A + + G + +ALL+ Sbjct: 305 ANGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEALLQ 362 Score = 61.4 bits (148), Expect = 3e-08, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 41/126 (32%), Gaps = 7/126 (5%) Query: 2 SILVTRPSPAG-EELVSRLRTLGQVAWHFPL-IEFSPGQQLPQLADQLAALGESDLLFAL 59 IL R G EE+V LR G P PQ+ + L A + D+L Sbjct: 372 RILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEALKA-HQVDILTFA 430 Query: 60 SQHAVAFAQSQLHQQDRK---WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 S V + Q W AIG TA G+ + Q+ E L+ Sbjct: 431 SSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAAQE-YTLEGLV 489 Query: 117 QLPELQ 122 + Sbjct: 490 EALIQA 495 >UniRef50_UPI0001C33642 uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase n=1 Tax=cyanobacterium UCYN-A RepID=UPI0001C33642 Length = 504 Score = 215 bits (547), Expect = 1e-54, Method: Composition-based stats. Identities = 49/255 (19%), Positives = 96/255 (37%), Gaps = 13/255 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR + + +L+ G PL+E P +L + + D L S Sbjct: 247 KVIITRSHESSSQFKFQLQEAGADVITLPLLEILPPSSWERLDGAIQEISSFDWLVLTSA 306 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V F +LH + +G+ TA L + P D I++ L++ Sbjct: 307 NGVKFFMERLHDLGKDIRILNNIKIAVVGKKTADYLKKFYLKPNFIPSD-FIADSLVENF 365 Query: 120 ELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 ++I GK+ L R GGR+++ +GA +T YQ E + + Sbjct: 366 -PEDINGKKILFPRVETGGRDILLKEFIKKGASITEVPAYQSICPKNIDNEIWKILKNEQ 424 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYRE--------HWLLHCRLLVVSERLAKLARELGWQDI 230 V ++ TS ++++ + L + + L + L + + +K +L + Sbjct: 425 VDIITFTSSKIVKHFYHLFKNIFPDSIEEKKILSKLDNVYLACIGPQTSKTCNDLFGRVD 484 Query: 231 KVADNADNDALLRAL 245 A + L L Sbjct: 485 VEAKEYTLEGLTNQL 499 Score = 70.3 bits (171), Expect = 6e-11, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 45/122 (36%), Gaps = 1/122 (0%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 +AGK+ +I R + L GA+V + + + + Sbjct: 242 PLAGKKVIITRSHESSSQFKFQLQEAGADVITLPLLEILPPSSWERLDGAIQEISSFDWL 301 Query: 183 VVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V+TS ++ + ++ L + ++ VV ++ A ++ + + + D+L Sbjct: 302 VLTSANGVKFFMERLHDLGKDIRILNNIKIAVVGKKTADYLKKFYLKPNFIPSDFIADSL 361 Query: 242 LR 243 + Sbjct: 362 VE 363 >UniRef50_B5FF96 Uroporphyrinogen-III synthase n=3 Tax=Aliivibrio RepID=B5FF96_VIBFM Length = 253 Score = 214 bits (545), Expect = 2e-54, Method: Composition-based stats. Identities = 100/245 (40%), Positives = 135/245 (55%), Gaps = 2/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ILVTRP + L L G A PLI PG +L QL ++L + D + A+S Sbjct: 1 MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFSSLNDGDFIIAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV + Q L Q +W + +Y A+G+ +A L + YP SE LL LP Sbjct: 61 QHAVEYTQKYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPT-HSDSEHLLALPV 119 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN GK+A+ILRGNGGR+LI L +VT+CE YQR AI +D + + WQ + V Sbjct: 120 LQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++VTSGE L S +W+L RLLV SER+ + A+ELG+Q I+ A N Sbjct: 180 TLIVTSGEQLSFFTSQFISTDL-NWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSD 238 Query: 241 LLRAL 245 LL + Sbjct: 239 LLHYI 243 >UniRef50_A3ZQM0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZQM0_9PLAN Length = 485 Score = 214 bits (545), Expect = 2e-54, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 97/247 (39%), Gaps = 9/247 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP E+L L LG + P I+ SP + D + L + + L S Sbjct: 240 RILITRPEHQAEDLAHTLAELGADVYLQPAIQISPPSDWTPVDDAIRRLHDFEWLVFSST 299 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + +L AIG TA L + + P + +E L++ Sbjct: 300 NGVRYFLDRLFASGEDLRAVGHLHIAAIGPGTADMLAKYHLKADVIPAE-YRAESLVEAL 358 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + +R L+ R + GR+++ L A G EVT YQ E W + + Sbjct: 359 QATTDR-QRFLLPRASRGRDVLPTGLAAGGGEVTEIVVYQSDDCMTLSPEIIEAWDDQPI 417 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+VTS + + L+ ++ + + +S + RE G + A D Sbjct: 418 DYVIVTSSAIARATVRLLGARAQQ-----TKFVSISPITSDALREAGVEPNIEAAVYTMD 472 Query: 240 ALLRALQ 246 ++ ALQ Sbjct: 473 GIVAALQ 479 Score = 79.5 bits (195), Expect = 1e-13, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 44/131 (33%), Gaps = 1/131 (0%) Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + + + G+R LI R E + TL GA+V Q + + Sbjct: 229 NWFQQRPLFGQRILITRPEHQAEDLAHTLAELGADVYLQPAIQISPPSDWTPVDDAIRRL 288 Query: 177 REVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + +V +S ++ L + H + + A + + + + Sbjct: 289 HDFEWLVFSSTNGVRYFLDRLFASGEDLRAVGHLHIAAIGPGTADMLAKYHLKADVIPAE 348 Query: 236 ADNDALLRALQ 246 ++L+ ALQ Sbjct: 349 YRAESLVEALQ 359 >UniRef50_Q7UPD0 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Rhodopirellula baltica RepID=Q7UPD0_RHOBA Length = 510 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 96/246 (39%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP +L L LG P I+ P ++ + + D L S+ Sbjct: 265 NVLVTRPKDQANQLAKPLEELGANVIVQPAIKICPPDDWSEVDAAIDQIETFDSLVFTSR 324 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L R +G TA L T + P + ++ LL Sbjct: 325 NGVKSFLDRLLDVGRDMRCLGGLKIAVVGDATANVLATYHLRADWIP-ESFDADALLTTL 383 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + K L++R GR+++ D L A G +V Y+ + + + + Sbjct: 384 QNAEPPLKSTLVVRTQRGRDVVTDGLRASGTQVREVVAYENWDVPEMDPATRGKIDEQPL 443 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + +TS + + + ++ R+ V+S A+ RELGW+ VA +A Sbjct: 444 DWITLTSPATARNVHRWLGD-----FIGETRIAVISPLTAQTVRELGWRVDAVAASATMQ 498 Query: 240 ALLRAL 245 +L +A+ Sbjct: 499 SLTQAI 504 Score = 72.6 bits (177), Expect = 1e-11, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 52/144 (36%), Gaps = 2/144 (1%) Query: 104 LYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI 163 + + ++E + + ++GK L+ R + L GA V + C Sbjct: 242 IVGEVTGLAESM-DWFSRRPLSGKNVLVTRPKDQANQLAKPLEELGANVIVQPAIKICPP 300 Query: 164 HYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLA 222 +A Q +V TS ++ + R+ L ++ VV + A + Sbjct: 301 DDWSEVDAAIDQIETFDSLVFTSRNGVKSFLDRLLDVGRDMRCLGGLKIAVVGDATANVL 360 Query: 223 RELGWQDIKVADNADNDALLRALQ 246 + + ++ D DALL LQ Sbjct: 361 ATYHLRADWIPESFDADALLTTLQ 384 >UniRef50_A6VL86 Uroporphyrinogen III synthase HEM4 n=7 Tax=Pasteurellaceae RepID=A6VL86_ACTSZ Length = 249 Score = 213 bits (543), Expect = 4e-54, Method: Composition-based stats. Identities = 96/247 (38%), Positives = 138/247 (55%), Gaps = 3/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP GE+L L G A H PL S G++L +L +++ L D +FA+S Sbjct: 1 MAVLVTRPDSRGEQLTEALNKAGVAALHMPLFSISAGRELNELPNKMYQLKAGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L +W + YFA+G+++A S Q + YP E SE LL LP+ Sbjct: 61 KNAVEFAAETLSNTGFRWRQDLIYFAVGQSSAEYFCEQSEQPVHYPYGHENSEGLLALPQ 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +Q + K LILRGNGGREL RGA+V ECY+R + YD ++ Q + Sbjct: 121 MQRLTDKTVLILRGNGGRELFPAQAVRRGAQVEIIECYRRVPVEYDPKKQTDLCQRAGIN 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW--QDIKVADNADN 238 ++ TS E+L +L + +P R+ WL CRL+ S R+AK A GW + I +A ADN Sbjct: 181 TIIATSSEILTRLTNFVPAEERD-WLTQCRLVTASYRVAKSAERAGWQKRQILIAPRADN 239 Query: 239 DALLRAL 245 L++ L Sbjct: 240 ATLVKML 246 >UniRef50_Q02D79 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02D79_SOLUE Length = 494 Score = 213 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 64/244 (26%), Positives = 95/244 (38%), Gaps = 9/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR + L + L +LG P IE P L +A L D L S Sbjct: 247 RIVVTRAREQADALGAALSSLGAGVIELPTIEIGPAADSGPLERAIAELETYDWLIFTSA 306 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F +L + AIG T A+ + + L ++ ++E LL+ Sbjct: 307 NGVRFFVERLDDLRKLRS---KICAIGPATRAAVEALHVKVDLMGKE-YVAEGLLEAFAA 362 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++AGKR L+ R R+L+ L RGA+V E Y+ A GA + AR Sbjct: 363 HDLAGKRVLLPRAAVARDLVPVELAKRGAQVDVVEAYRTAAPAGLGARVREVF-ARRPDC 421 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ L R+ + + ARELG A D L Sbjct: 422 VTFTSSSTVRNFVEAAGAGA----LEGVRVASIGPVTSATARELGVAVTVEARPFTVDGL 477 Query: 242 LRAL 245 + A+ Sbjct: 478 VDAV 481 >UniRef50_D1VCA0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Frankia sp. EuI1c RepID=D1VCA0_9ACTO Length = 617 Score = 212 bits (541), Expect = 8e-54, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 93/251 (37%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R L LR+ G P I P + + + L G + Sbjct: 343 TVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFT 402 Query: 60 SQHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV Q ++ ++ AIG TA AL + + L P ++ SE LL Sbjct: 403 SVNAVKAVQEKVEERSLDARSFAGVKVAAIGEATAEALRSFGIRPDLVPAGQQSSEGLLA 462 Query: 118 LPELQNIAGK---RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + + R L+ R + E++ L RG +V Y+ A Sbjct: 463 DWPEYDSSLDLLDRVLLPRADIATEILEAGLKERGWQVDDVTAYRTVRAAPPPAPIREAL 522 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V VV TS ++ L + + + + + + A+ A+ELG + A Sbjct: 523 KGGRVDAVVFTSSSTVRNLVGIAGKPH-----ETTVIACIGPKTAETAQELGLRVDVEAP 577 Query: 235 NADNDALLRAL 245 A +L+ AL Sbjct: 578 EATIASLVTAL 588 Score = 62.2 bits (150), Expect = 2e-08, Method: Composition-based stats. Identities = 19/132 (14%), Positives = 39/132 (29%), Gaps = 4/132 (3%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAEEAMR 173 L E + + G L+ R ++ D L + GA Sbjct: 331 LSWWETRALFGWTVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITG 390 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKV 232 + V TS ++ + + + + ++ + E A+ R G + V Sbjct: 391 LVSGRYQWVAFTSVNAVKAVQEKVEERSLDARSFAGVKVAAIGEATAEALRSFGIRPDLV 450 Query: 233 AD-NADNDALLR 243 ++ LL Sbjct: 451 PAGQQSSEGLLA 462 >UniRef50_A0Y9F1 Uroporphyrinogen-III synthase n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0Y9F1_9GAMM Length = 264 Score = 212 bits (540), Expect = 9e-54, Method: Composition-based stats. Identities = 68/249 (27%), Positives = 114/249 (45%), Gaps = 8/249 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQ-----LAALGESDLLF 57 +LVTRP +LV+ + T G A H P+I Q AL + + Sbjct: 9 VLVTRPQGQAADLVAAIETAGGCAIHCPVIAIERLSDSDTAEQQRCKQQFMALDQFQHVI 68 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLL 116 +S +AV + + Q + P +++ IG +T L + SE LL Sbjct: 69 FISTNAVKYGLQWIDQYWPQLPVGINWYGIGGSTTQLLRQEGVPVNDTVECGTMNSEALL 128 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 Q LQ + ++ LI+RG GGR+ + L RGAEV + ECY+R + + + Sbjct: 129 QHKGLQAFSHQKVLIVRGVGGRDYLQQVLQQRGAEVEYAECYRRR-VAVTSTDLISKIVE 187 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 E+ V + SGE ++ L+ + + L+V R+A++A + G++ + ADNA Sbjct: 188 YEINTVCLNSGESVENFCQLVGPEHW-SIIKGLLLVVPGARVAEIAGKKGFERVFCADNA 246 Query: 237 DNDALLRAL 245 N A++ A+ Sbjct: 247 SNQAMIAAI 255 Score = 41.0 bits (95), Expect = 0.038, Method: Composition-based stats. Identities = 11/123 (8%), Positives = 33/123 (26%), Gaps = 1/123 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R + L L+ G + L ++ E + + S Sbjct: 140 KVLIVRGVGGRDYLQQVLQQRGAEVEYAECYRRRVAVTSTDLISKIVE-YEINTVCLNSG 198 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +V + + + G A +++ + ++ + + Sbjct: 199 ESVENFCQLVGPEHWSIIKGLLLVVPGARVAEIAGKKGFERVFCADNASNQAMIAAIGDE 258 Query: 122 QNI 124 + Sbjct: 259 DQL 261 >UniRef50_Q602K2 Uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase n=1 Tax=Methylococcus capsulatus RepID=Q602K2_METCA Length = 672 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 128/246 (52%), Gaps = 3/246 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP E L + T G A FPL++ P Q + A L + D +S Sbjct: 1 MRVLVTRPKEQAEPLCRLIETAGGKAVRFPLLDIEPSAQAEEGAALLRQASDWDWWIFVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV A + R P AIG+ TA AL L P+ + SE LL+ P Sbjct: 61 VNAVNRA--RALDVLRPDGAGPRIAAIGKATADALVDGGIAVDLVPESQANSEGLLETPP 118 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++++AG+R LI+RG GGRE + + L RGA V + E Y+R +H + + Sbjct: 119 MRDVAGRRILIVRGEGGRETLKERLVERGALVQYAELYRRVPVHTGAEALIEGLRTAGLD 178 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 M+ TSGE ++ L+ L+P R L+ L+V+SERL A LG++ +KVAD A + A Sbjct: 179 MLTATSGEAIEHLYRLVPPEDRPR-LVETPLVVISERLKNQAGSLGFRHVKVADAASDAA 237 Query: 241 LLRALQ 246 +L+AL+ Sbjct: 238 VLQALE 243 >UniRef50_C2WCN0 Uroporphyrinogen III synthase HEM4 n=2 Tax=Bacillus RepID=C2WCN0_BACCE Length = 254 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 38/245 (15%), Positives = 86/245 (35%), Gaps = 6/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+TR ++ ++ + PL+ G + D + S+ Sbjct: 8 TVLITRAKHQARQMSVAVKKESGIPMEIPLLRME-GVSQQVFQSVSQQIHLYDWIIFTSK 66 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V+F L + + P A+G T L + P ++E + Sbjct: 67 NGVSFFLDGLGE---RIPSTVRIAAVGVKTGQELKKRGYEVCFVPT-SFVAETFAEEFGR 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + + L +GN R++I L G + Y+ + + ++ ++ + Sbjct: 123 KLSGKEHILFPKGNLARDVIPTKLRELGVLLEEFVVYETKTNDTKQQDLIVALESGKIDV 182 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ L+ W+ C + + + AR + D+ V +AL Sbjct: 183 VTFTSPSTVRSFVKLLEGTNWREWIKKCTIACIGPITEQEARRY-FADVIVPKEYTIEAL 241 Query: 242 LRALQ 246 ++ + Sbjct: 242 IQCIS 246 >UniRef50_D2M0D2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M0D2_BACS4 Length = 257 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 38/246 (15%), Positives = 95/246 (38%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L TR L L G PLI P++ + + + D + S Sbjct: 9 TLLNTRAIHQAAPLTKYLEKHGGNVVEIPLISMKKTSD-PKIKEAIKMIHTYDYIVFTST 67 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 ++++F L +Q + +G++T +L+ + P +E L Sbjct: 68 NSISFFLEILKEQGLSKREICNMKFAVVGKSTLRSLNKEGFDADIIPPI-FDAEHLASAL 126 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + AG++ L + + R+++ L G ++ Y+ D A+ + + Sbjct: 127 KTELSAGEKVLYPKSDLARDVLTRELHKVGIQIDDPSVYETVFRIDDKAKLNELIKKNLI 186 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++ TS + +S + + + + V+ ++ ++ G +++ + + Sbjct: 187 HIIIFTSPSTVHSFFSQVDKEVVMNNVDKLHFAVIGSVTSRALKDEGIEEMIIPKEFTTE 246 Query: 240 ALLRAL 245 AL+ A+ Sbjct: 247 ALVHAI 252 Score = 62.2 bits (150), Expect = 2e-08, Method: Composition-based stats. Identities = 18/125 (14%), Positives = 38/125 (30%), Gaps = 2/125 (1%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + G L R + L G V +EA++ + Sbjct: 4 PLQGYTLLNTRAIHQAAPLTKYLEKHGGNVVEIPLISMKKTSDPKIKEAIKMI-HTYDYI 62 Query: 183 VVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS + ++ + + + + VV + + + G+ + D + L Sbjct: 63 VFTSTNSISFFLEILKEQGLSKREICNMKFAVVGKSTLRSLNKEGFDADIIPPIFDAEHL 122 Query: 242 LRALQ 246 AL+ Sbjct: 123 ASALK 127 >UniRef50_Q2B6K9 Uroporphyrinogen-III synthetase n=1 Tax=Bacillus sp. NRRL B-14911 RepID=Q2B6K9_9BACI Length = 259 Score = 210 bits (536), Expect = 2e-53, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 87/244 (35%), Gaps = 5/244 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LV R +R+ G + PL+ F P + ++ + L D + S+ Sbjct: 12 KVLVPRGKDQAGPFSELIRSYGGIPVEIPLLAFRPAEVTEEILHAVRELPTYDWVIFTSK 71 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A+ S + P AIG T A P++ +E + Sbjct: 72 NALETFISFAGRNAV----FPKIAAIGTKTERAAEESGLAVSFTPEE-FAAEGFIDEFLP 126 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G + LI +GN R I D L GAE Y+ G + A+ + + + Sbjct: 127 FVEKGMKVLIPKGNKARSYIADELKRAGAEPQEIIIYETGFPEDSGEKLAVMLKNGSLDV 186 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS ++ ++ + E + C + + K A ELG V + L Sbjct: 187 LAFTSPSTVEHFMEIVRKTGAEAAIKGCLVACIGPVTQKRAEELGLGVHVVPAGYTIEDL 246 Query: 242 LRAL 245 +++ Sbjct: 247 AKSI 250 Score = 63.7 bits (154), Expect = 6e-09, Method: Composition-based stats. Identities = 16/129 (12%), Positives = 37/129 (28%), Gaps = 2/129 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +L+ + + A + L+ G + E + + + G D+L S Sbjct: 132 MKVLIPKGNKARSYIADELKRAGAEPQEIIIYETGFPEDSGEKLAVMLKNGSLDVLAFTS 191 Query: 61 QHAVAFAQSQLHQQDRK-WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V + + + + IG T + + E L + Sbjct: 192 PSTVEHFMEIVRKTGAEAAIKGCLVACIGPVTQKRAEELGL-GVHVVPAGYTIEDLAKSI 250 Query: 120 ELQNIAGKR 128 + ++ Sbjct: 251 AAELNQRRK 259 Score = 59.9 bits (144), Expect = 7e-08, Method: Composition-based stats. Identities = 16/124 (12%), Positives = 34/124 (27%), Gaps = 5/124 (4%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E +AGK+ L+ RG + + + G + Sbjct: 4 ESLPLAGKKVLVPRGKDQAGPFSELIRSYGGIPVEIPLLAFRPAEVTEEILHAVRELPTY 63 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+ TS L+ S + ++ + + + A E G + + Sbjct: 64 DWVIFTSKNALETFISFAGRNAVFP-----KIAAIGTKTERAAEESGLAVSFTPEEFAAE 118 Query: 240 ALLR 243 + Sbjct: 119 GFID 122 >UniRef50_Q3JDS0 Uroporphyrinogen-III synthase n=2 Tax=Nitrosococcus oceani RepID=Q3JDS0_NITOC Length = 265 Score = 210 bits (535), Expect = 3e-53, Method: Composition-based stats. Identities = 74/245 (30%), Positives = 114/245 (46%), Gaps = 3/245 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP+ E+L + G A FP +E + + + + L + +S Sbjct: 16 RVLVTRPAEQAEKLSQAIELEGGQAVRFPTVEIGDSEVPAVVEEIIGRLDDFHWAVFVSA 75 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + R+ P +GR TA AL L P SE LL + EL Sbjct: 76 NAVQRGVPWVFA-RREMPANLKIAVVGRATAQALGNFGLYPRLCPSYGYNSEALLAMDEL 134 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD-GAEEAMRWQAREVT 180 Q++ G++ ++ R +GGREL+ TLT RGA+V + E Y+RC A V Sbjct: 135 QDMKGQQVVLFRASGGRELLAKTLTKRGAKVEYAEVYRRCLPSPSVAANLRQVLVNVPVD 194 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+ TS +L+ L L + E L L+V+ R + ARELG+ I VA + A Sbjct: 195 VVITTSKAVLENLCHLAGEPLLEK-LRRTPLVVIGSRQVQQARELGFTQIWVAQEPSDAA 253 Query: 241 LLRAL 245 L++ + Sbjct: 254 LVQTI 258 Score = 42.1 bits (98), Expect = 0.018, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 41/127 (32%), Gaps = 3/127 (2%) Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 Q +AG+R L+ R E + + G + + E + + Sbjct: 6 FIPQQRLAGRRVLVTRPAEQAEKLSQAIELEGGQAVRFPTVEIGDSEVPAVVEEIIGRLD 65 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD-NA 236 + V S +Q+ + + R + ++ VV A+ G Sbjct: 66 DFHWAVFVSANAVQRGVPWV--FARREMPANLKIAVVGRATAQALGNFGLYPRLCPSYGY 123 Query: 237 DNDALLR 243 +++ALL Sbjct: 124 NSEALLA 130 >UniRef50_C7N5L1 Uroporphyrin-III C-methyltransferase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N5L1_SLAHD Length = 546 Score = 209 bits (532), Expect = 8e-53, Method: Composition-based stats. Identities = 54/259 (20%), Positives = 83/259 (32%), Gaps = 15/259 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR LR LG P IE + + + + D L S Sbjct: 284 RIVVTRSRTQAGTFSVLLRDLGADVVEIPTIEICDPSSFDVIDAAIERIADYDWLVFTSV 343 Query: 62 HAVAFAQSQLHQ-------------QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQD 108 + V +L + +D + AIG TA AL P + Sbjct: 344 NGVDRFFKRLAEPCASAVGGSPKQTRDTRTLAGLRVAAIGPATADALTRHGIMPDAVPGE 403 Query: 109 REISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR-CAIHYDG 167 V + AG + LI R RE + + L G E T Y+ Sbjct: 404 YRAEAVFDAMRAAGLAAGDKILIARAKEARETLPEMLAEAGCEATVAPVYETRRPADEQT 463 Query: 168 AEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW 227 AE R EV V TS + L +++ + L L + + +LG Sbjct: 464 AELCGRIVNGEVDAVTFTSSSTARNLVAMLGE-GAVETLSKLDLFSIGPITTQTLAKLGL 522 Query: 228 QDIKVADNADNDALLRALQ 246 ++ AD L+ ++ Sbjct: 523 TNVHQADTYTIPGLVACIR 541 Score = 71.8 bits (175), Expect = 2e-11, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 43/143 (30%), Gaps = 12/143 (8%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 LQ E + G+R ++ R L GA+V + C +A + Sbjct: 272 LQWFENAPLFGRRIVVTRSRTQAGTFSVLLRDLGADVVEIPTIEICDPSSFDVIDAAIER 331 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHW------------LLHCRLLVVSERLAKLAR 223 + +V TS + + + + + L R+ + A Sbjct: 332 IADYDWLVFTSVNGVDRFFKRLAEPCASAVGGSPKQTRDTRTLAGLRVAAIGPATADALT 391 Query: 224 ELGWQDIKVADNADNDALLRALQ 246 G V +A+ A++ Sbjct: 392 RHGIMPDAVPGEYRAEAVFDAMR 414 >UniRef50_B2UQJ4 Uroporphyrin-III C-methyltransferase n=6 Tax=Bacteria RepID=B2UQJ4_AKKM8 Length = 506 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 89/251 (35%), Gaps = 13/251 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR EL +RLR LG P+I +P + A+ + D L S Sbjct: 256 RIVVTRTRAQAGELSARLRRLGAEVLEMPVIRIAPPSNRREFAESVVHAHTYDWLVFSSP 315 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V R AIG T L + P+ ++E L++ Sbjct: 316 NGVERFFQAFFAVYRDIRSIGGARIAAIGPGTEAKLREYGLAVDVMPKK-FVAEGLVKAF 374 Query: 120 -----ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 E+ I L +RG R +I D L A GA V C Y+ A D A + Sbjct: 375 RDAREEIGTIEHSTFLWVRGEEARRVIYDGLNALGAIVDECIAYKTEAETEDVAGAQAAF 434 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + R +V TS + + L W CR + +ELG A Sbjct: 435 RERGADIVTFTSSSTAENFFKL-----GLPWPEGCRAASIGPVTTATLKELGHAPSITAK 489 Query: 235 NADNDALLRAL 245 D + L+ A+ Sbjct: 490 THDINGLVEAI 500 Score = 74.5 bits (182), Expect = 3e-12, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 39/130 (30%), Gaps = 1/130 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + GKR ++ R + L GAEV + Sbjct: 244 LNWFEKLPLFGKRIVVTRTRAQAGELSARLRRLGAEVLEMPVIRIAPPSNRREFAESVVH 303 Query: 176 AREVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 A +V +S +++ + + + R+ + RE G + Sbjct: 304 AHTYDWLVFSSPNGVERFFQAFFAVYRDIRSIGGARIAAIGPGTEAKLREYGLAVDVMPK 363 Query: 235 NADNDALLRA 244 + L++A Sbjct: 364 KFVAEGLVKA 373 >UniRef50_Q0A578 Uroporphyrinogen-III synthase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A578_ALHEH Length = 261 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 72/245 (29%), Positives = 113/245 (46%), Gaps = 2/245 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ L L G W P +E P + A +AALGE+D L +S + Sbjct: 9 VLVTRPAHQAAGLCRTLEAAGARVWALPTLEIVPQPESALPAAAVAALGEADWLIFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV + + + + A+G+ T ALH V PQ SE L + P Sbjct: 69 AVHHGLACMARHGVRPRPDARIAAVGKGTERALHRVGLSVTAVPQAGFTSEDLAREPAFG 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R +I+RG+ GR + + L +GAEV F Y+ D QA + V Sbjct: 129 DMRGQRVMIVRGDSGRAWLAEHLRGQGAEVAFLAVYRAVRPQVDAQPVVEALQAGRLHSV 188 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIKVADNADNDAL 241 ++TS L LW ++ R + L+ VS R+A+ A + G + VA + ++ L Sbjct: 189 IITSVRGLDNLWFMLGDSGRV-LVQRRALVTVSPRIARYAEQAGHTGPVVVARSPADEDL 247 Query: 242 LRALQ 246 L+A+ Sbjct: 248 LQAVH 252 Score = 52.2 bits (124), Expect = 1e-05, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 34/122 (27%), Gaps = 2/122 (1%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + AG L+ R + TL A GA V + A E Sbjct: 1 MALPAGYGVLVTRPAHQAAGLCRTLEAAGARVWALPTLEIVPQPESALPAAAVAALGEAD 60 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN-ADND 239 ++ S + + + + R+ V + + +G V ++ Sbjct: 61 WLIFVSPNAVHHGLACMARHGVRPRP-DARIAAVGKGTERALHRVGLSVTAVPQAGFTSE 119 Query: 240 AL 241 L Sbjct: 120 DL 121 Score = 46.0 bits (108), Expect = 0.001, Method: Composition-based stats. Identities = 16/117 (13%), Positives = 26/117 (22%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++ R L LR G + Q Q + G + S Sbjct: 134 RVMIVRGDSGRAWLAEHLRGQGAEVAFLAVYRAVRPQVDAQPVVEALQAGRLHSVIITSV 193 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + L R + + A + E LLQ Sbjct: 194 RGLDNLWFMLGDSGRVLVQRRALVTVSPRIARYAEQAGHTGPVVVARSPADEDLLQA 250 >UniRef50_C4ZNN4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Thauera sp. MZ1T RepID=C4ZNN4_THASP Length = 267 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 72/247 (29%), Positives = 113/247 (45%), Gaps = 5/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++V RP E L +RL G A FP+I P L + L E DL F +S Sbjct: 20 TLVVMRPREQAESLCARLEAAGGRALRFPVIAVGPALDPAPLQAIVGRLDEFDLAFFVSP 79 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE- 120 +AV A + R WP +G+ + + ++ PQD SE ++ LPE Sbjct: 80 NAVDHAMRAILP-QRTWPARLRVATVGKGSQRVMQDWGFANVIAPQDGFDSEAVIALPEF 138 Query: 121 -LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G++ LI RG+GGREL+ DTL RGA V + CY+R D A E+ Sbjct: 139 AADAVRGRKVLIFRGDGGRELLADTLRERGASVEYVTCYRRHCPEADPALLLGPAARGEL 198 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++TS E ++ L ++ L + R+ AR G++ + A +D Sbjct: 199 DGLLLTSSEGVRNLEWMLGTEGLAA-LHAVTVFATHPRIVAQARAAGFERVVETP-AGDD 256 Query: 240 ALLRALQ 246 L++AL+ Sbjct: 257 GLMQALE 263 >UniRef50_A4YBG3 Uroporphyrinogen III synthase HEM4 n=21 Tax=Shewanella RepID=A4YBG3_SHEPC Length = 246 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 83/248 (33%), Positives = 124/248 (50%), Gaps = 5/248 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +L+TRP + +V L G + PL+ P + D L +D++ +S Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGITHYVTPLLGVEPTNDITT--DASHPLAGTDIIICIS 58 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV FA L++ + + P YFA+G T AL + + P D + +E LL L Sbjct: 59 ANAVIFANKALNKINAQIATWPKVQYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLTL 118 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 LQ+I K+ I+RG GGRE + + LT RGA V + E YQR DG +WQ Sbjct: 119 ASLQHIPAKKVTIIRGVGGREALAEQLTRRGANVRYWEVYQRVCPPLDGYAITQQWQHFG 178 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + +VVTSGE+L L L+P+ WL C ++V S R+ A G + A A++ Sbjct: 179 IDTIVVTSGEVLNNLIKLVPKE-LFAWLRSCHIIVPSNRVEAQAHAFGINHVTNACAANS 237 Query: 239 DALLRALQ 246 A+L AL+ Sbjct: 238 KAVLNALK 245 >UniRef50_A6W5L9 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase n=27 Tax=Actinomycetales RepID=A6W5L9_KINRD Length = 607 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 50/251 (19%), Positives = 87/251 (34%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R + ++L G A P I P + Q+ + L G + + Sbjct: 329 RVLVPRTKEQAGGVTAKLSDHGATAEVVPTISVEPPRTPQQMEKAVKGLVTGRYEWIGFT 388 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + + + A+G TA AL + L P+ + + LL+ Sbjct: 389 SVNAVRAVREKFTEYGLDARAFSGLKVAAVGGVTADALREWGIEPDLVPEGEQSASGLLE 448 Query: 118 -LPELQNIAG--KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 P ++ R + R + + + L G EV Y+ A Sbjct: 449 AWPPYDDVLDPINRVFLPRADIATDTLVAGLQENGWEVDDVTAYRTVRAAPPAAPVRDAI 508 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + VV TS ++ L + + + + + AK A E G + +A Sbjct: 509 KTGAFDAVVFTSSSTVRNLVGIAGKPHP-----STVVACIGPATAKTAEEHGLRVDVLAP 563 Query: 235 NADNDALLRAL 245 DAL+ AL Sbjct: 564 EPSADALVDAL 574 Score = 59.9 bits (144), Expect = 7e-08, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 33/123 (26%), Gaps = 4/123 (3%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAEEAMRWQAREVTMVV 183 G R L+ R + L+ GA + + Sbjct: 327 GWRVLVPRTKEQAGGVTAKLSDHGATAEVVPTISVEPPRTPQQMEKAVKGLVTGRYEWIG 386 Query: 184 VTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVAD-NADNDAL 241 TS ++ + ++ + ++ V A RE G + V + L Sbjct: 387 FTSVNAVRAVREKFTEYGLDARAFSGLKVAAVGGVTADALREWGIEPDLVPEGEQSASGL 446 Query: 242 LRA 244 L A Sbjct: 447 LEA 449 >UniRef50_Q491Z5 Uroporphyrinogen III synthase n=6 Tax=Gammaproteobacteria RepID=Q491Z5_BLOPB Length = 249 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 118/245 (48%), Positives = 159/245 (64%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRPSP GE+LV++L + G+ A+H PLI FS G++L L +L L E D L +S Sbjct: 1 MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHA+ +A +QL WP Y++IG T++ ++ +SG + YP +E SE LLQLPE Sbjct: 61 QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L GKRALILRGN GR ++ DTL RG V CECY R Y+ ++ + Sbjct: 121 LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVVTSGE+LQ L+ LIP+ YR WL+ C+L+VVS RLAKLAR LGW +I +A +A+N+ Sbjct: 181 TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI 240 Query: 241 LLRAL 245 L L Sbjct: 241 LFHLL 245 >UniRef50_C5V3N2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Gallionella ferruginea ES-2 RepID=C5V3N2_9PROT Length = 248 Score = 205 bits (523), Expect = 9e-52, Method: Composition-based stats. Identities = 82/246 (33%), Positives = 124/246 (50%), Gaps = 15/246 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +LVTRP L + G A FP++E +P L +L +Q++ + +++L +S Sbjct: 9 LKVLVTRPRDQAFTLAQAIGQQGGTAVLFPMLEIAPVPDLLRLQEQVSHVEQANLAIFIS 68 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + + K P +G +A AL + ++ P +R SE LL PE Sbjct: 69 PNAVKYGMAA---TGGKVPA--RVATVGEGSAKALRALGIAHVIVPVERFDSEGLLARPE 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQNI G +I RG+GGREL+GDTL RGA V + CY RC +E A V Sbjct: 124 LQNIDGWHVMIFRGDGGRELLGDTLRERGARVEYVTCYLRCKPQCPVSELA------GVD 177 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ VTS E L L +I + L V+ R+A+LA+ LGW + + ++ +D Sbjct: 178 LITVTSSEALNHLSQMI---VDSKEVFDRPLFVIHPRIAELAKRLGWSKVHLTES-GDDG 233 Query: 241 LLRALQ 246 LL LQ Sbjct: 234 LLAGLQ 239 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 98/246 (39%), Gaps = 6/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ RP+ LV RLR LG A PLI P + L LA L D + S Sbjct: 311 RVLLVRPAGQETFLVERLRALGAEAVIHPLIRILPPEDWGPLDAALADLARFDWVVFTSA 370 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L + R AIG TA AL + + P D+ I+E + Sbjct: 371 NGVRATLERLRLLGGGSELLREKRLAAIGPATARALREYELEPDIVP-DKFIAEAVAAQL 429 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + +AG R L+ R RE++ L GA V Y+ + D +A + Sbjct: 430 IARGVAGARVLVARAAEAREILPRRLEEAGATVVVVPAYRTELLPLD-EAIQAALEAGTI 488 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + +T+ + L + + R R+ + A ARELG + VAD + Sbjct: 489 DWIFLTASSTARALAAALGDIKRLS--DRIRIAAIGPVTAGTARELGLRVDVVADTYTAE 546 Query: 240 ALLRAL 245 L+ A+ Sbjct: 547 GLIEAV 552 Score = 73.0 bits (178), Expect = 8e-12, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 36/122 (29%), Gaps = 3/122 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LV R + A E L RL G P + L G D +F + Sbjct: 438 RVLVARAAEAREILPRRLEEAGATVVVVPAYRTELLPLDEAIQAAL-EAGTIDWIFLTAS 496 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + L R AIG TA + + + D +E L++ Sbjct: 497 STARALAAALGDIKR-LSDRIRIAAIGPVTAGTARELGLRVDVV-ADTYTAEGLIEAVVR 554 Query: 122 QN 123 Sbjct: 555 AE 556 Score = 69.9 bits (170), Expect = 6e-11, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 42/125 (33%), Gaps = 1/125 (0%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + G+R L++R G + + L A GAE + G +A Sbjct: 305 DPLRGRRVLLVRPAGQETFLVERLRALGAEAVIHPLIRILPPEDWGPLDAALADLARFDW 364 Query: 182 VVVTSGEMLQQLWSLIPQW-YREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV TS ++ + L RL + A+ RE + V D +A Sbjct: 365 VVFTSANGVRATLERLRLLGGGSELLREKRLAAIGPATARALREYELEPDIVPDKFIAEA 424 Query: 241 LLRAL 245 + L Sbjct: 425 VAAQL 429 >UniRef50_Q4JSX6 Uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase n=5 Tax=Actinomycetales RepID=Q4JSX6_CORJK Length = 628 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 46/252 (18%), Positives = 89/252 (35%), Gaps = 13/252 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R + +RL + G + P I P + Q+ + L G + Sbjct: 348 TVLVPRAKNQAGPMSTRLASHGAIPVEVPTISVEPPRSPVQMERAIKGLVDGRYHWIVFT 407 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQD-REISEVLL 116 S +AV +L + A+G T+ A+ + L P+D + L+ Sbjct: 408 SVNAVKAVWEKLREFGLDARALAGVRVAAVGPKTSQAVKDLGITPELLPKDDARNAAGLV 467 Query: 117 QLPELQNIAGK---RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 ++ + R L+ R + +++ D L G +V Y+ E Sbjct: 468 EVFPPHDPDLDLVDRVLLPRADIATDVLVDGLIELGWDVEDVVAYRTVRAAPPSPEIRDM 527 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V TS ++ L + + + + + A+ ARE G + + Sbjct: 528 IKTGGFDAVCFTSSSTVKNLVGIAGKPH-----ARTIIACIGPMAAQTAREHGLRVDVMP 582 Query: 234 DNADNDALLRAL 245 + A L+ AL Sbjct: 583 EAAGVPELVDAL 594 Score = 59.1 bits (142), Expect = 1e-07, Method: Composition-based stats. Identities = 16/119 (13%), Positives = 37/119 (31%), Gaps = 3/119 (2%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQAR 177 E + + G L+ R + L + GA Sbjct: 340 ENRALYGWTVLVPRAKNQAGPMSTRLASHGAIPVEVPTISVEPPRSPVQMERAIKGLVDG 399 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +V TS ++ +W + ++ + L R+ V + ++ ++LG + + Sbjct: 400 RYHWIVFTSVNAVKAVWEKLREFGLDARALAGVRVAAVGPKTSQAVKDLGITPELLPKD 458 >UniRef50_A1K456 HemD protein n=2 Tax=Rhodocyclaceae RepID=A1K456_AZOSB Length = 265 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 68/245 (27%), Positives = 106/245 (43%), Gaps = 5/245 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + VTRP L +R G FP++ + L + +A L DL F +S + Sbjct: 19 VAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPN 78 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV A + + R WP + +G+ + AL ++ P + SE +L LP Sbjct: 79 AVEHALAAVKA-RRHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFS 137 Query: 123 N--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 I G+R +I RG+GGREL+ D L ARGA V CY+R D A + Sbjct: 138 ATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLD 197 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+TS E ++ L ++ + L + R+ AR G+ ++ +D Sbjct: 198 ALVLTSSEGVRNLVEMVGEKG-FGVLRRVTVFAPHPRIVAHARAAGFDRVEETP-PGDDG 255 Query: 241 LLRAL 245 LL L Sbjct: 256 LLETL 260 Score = 46.0 bits (108), Expect = 0.001, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 31/122 (25%), Gaps = 4/122 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLI-EFSPGQQLPQLADQLAALGESDLLFALS 60 +++ R E L LR G V + P L A G D L S Sbjct: 145 RVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRPAADAAPLIQA-AGTGRLDALVLTS 203 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + ++ R FA ++ + LL+ Sbjct: 204 SEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARAAGFDRVEETPPGDD--GLLETLV 261 Query: 121 LQ 122 Sbjct: 262 RH 263 >UniRef50_Q1JVU0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JVU0_DESAC Length = 264 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 57/246 (23%), Positives = 89/246 (36%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR + + V L G A PLIE +L + LA L + D L S Sbjct: 10 RILVTRAAHQAQSFVRLLEAQGATAITCPLIEIVAPASWQRLDEALARLQDYDDLILTSV 69 Query: 62 HAVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV S+L + + +G TA +L Q L P + +E ++ Sbjct: 70 NAVDMVFSRLGKGVVPQTALDGVRLVCVGPKTAKSLQHYGYQPDLQPDE-YRAEAVVAAL 128 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + G++ L R R+LI +LT GAEV Y+ + + V Sbjct: 129 TAEGVRGRKVLYPRAELARDLIPSSLTQAGAEVDDPIAYRTLPAKGSALQIRGLLDDKAV 188 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V +S + L+ H L + A + G D Sbjct: 189 DVVTFSSSSSVDNFVDLLGDDVTL-LTRHVVLASIGPLTTATAVKHGLAIEVEPAEYTLD 247 Query: 240 ALLRAL 245 L++AL Sbjct: 248 GLVQAL 253 Score = 71.0 bits (173), Expect = 3e-11, Method: Composition-based stats. Identities = 26/124 (20%), Positives = 51/124 (41%), Gaps = 1/124 (0%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GKR L+ R + L A+GA C + A + + ++ + Sbjct: 5 PLTGKRILVTRAAHQAQSFVRLLEAQGATAITCPLIEIVAPASWQRLDEALARLQDYDDL 64 Query: 183 VVTSGEMLQQLWSLIPQW-YREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++TS + ++S + + + L RL+ V + AK + G+Q D +A+ Sbjct: 65 ILTSVNAVDMVFSRLGKGVVPQTALDGVRLVCVGPKTAKSLQHYGYQPDLQPDEYRAEAV 124 Query: 242 LRAL 245 + AL Sbjct: 125 VAAL 128 Score = 41.8 bits (97), Expect = 0.023, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 35/125 (28%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L R A + + S L G P + L D++ S Sbjct: 137 KVLYPRAELARDLIPSSLTQAGAEVDDPIAYRTLPAKGSALQIRGLLDDKAVDVVTFSSS 196 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +V L R +IG T + P + + ++ L + Sbjct: 197 SSVDNFVDLLGDDVTLLTRHVVLASIGPLTTATAVKHGLAIEVEPAEYTLDGLVQALIDY 256 Query: 122 QNIAG 126 N +G Sbjct: 257 FNPSG 261 >UniRef50_C1F250 Uroporphyrinogen-III synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F250_ACIC5 Length = 275 Score = 205 bits (521), Expect = 1e-51, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 89/257 (34%), Gaps = 15/257 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR L L +LG P I P L L L D + S Sbjct: 15 RILVTRAEHQAGRLSHILASLGAEPVEVPAIRILPPDTYEPLDHALRTLSSYDWIILTSA 74 Query: 62 HAVAFAQSQLHQQDRKWPRL----------PDYFAIGRTTALALHTVSGQKILYPQDREI 111 + V S++ Q P P A+G +TA A V L P D+ + Sbjct: 75 NTVNAMLSRIEQLGMVSPASQTGQAIYGPMPKIAAVGPSTAKAAARVRWNIDLMP-DKYV 133 Query: 112 SEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 +E LL+ + G+R L+ R + R++I + L +G + E Y+ A+ Sbjct: 134 AESLLEAL-GDKLRGQRVLLARSSRSRDVIPEALREQGVNLDVVEAYRTEIPEESLAQIR 192 Query: 172 MRWQAREVT---MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ 228 + TS + + L+ + + +K R+ W+ Sbjct: 193 TLFGDGRPHGLAAATFTSSSTVDNFFKLMRASGLAFVPSTLPAISIGPITSKTLRDHAWE 252 Query: 229 DIKVADNADNDALLRAL 245 AD D L+ A+ Sbjct: 253 PSAEADPHSVDGLVDAV 269 Score = 68.3 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 43/133 (32%), Gaps = 9/133 (6%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q ++G+R L+ R + L + GAE + + Sbjct: 9 QPLSGRRILVTRAEHQAGRLSHILASLGAEPVEVPAIRILPPDTYEPLDHALRTLSSYDW 68 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHC---------RLLVVSERLAKLARELGWQDIKV 232 +++TS + + S I Q ++ V AK A + W + Sbjct: 69 IILTSANTVNAMLSRIEQLGMVSPASQTGQAIYGPMPKIAAVGPSTAKAAARVRWNIDLM 128 Query: 233 ADNADNDALLRAL 245 D ++LL AL Sbjct: 129 PDKYVAESLLEAL 141 >UniRef50_Q7NL92 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Gloeobacter violaceus RepID=Q7NL92_GLOVI Length = 508 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 82/246 (33%), Gaps = 3/246 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTR + ++L LG P + + L +A L L S + Sbjct: 247 ILVTRAADQAGGFSAQLEALGASVLEMPALVVTAPTSWEPLDRAIAQLAGYRWLLLTSAN 306 Query: 63 AVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V ++L R A+G TA A T P +L P+ Sbjct: 307 GVEAFFARLTHHRRDLRALGGVRVAAVGPKTAQAARTHGLICDFVPGQYVSDGLLTDFPD 366 Query: 121 LQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + I G+R L +R GGRE I + GA V Y +A + Sbjct: 367 IAGIYGERVLFVRVESGGRETITEQFRRWGALVDEVAGYATGCPDSAEPGCVAALRAGRI 426 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 S + ++ L+ E L R+ + + + RE + A+ D Sbjct: 427 DCATFASAKTVRHFARLLQGEELESLLRKVRIASIGPQTSAACRETLGRVDVEAEVFTLD 486 Query: 240 ALLRAL 245 L +A+ Sbjct: 487 GLAQAI 492 Score = 60.2 bits (145), Expect = 6e-08, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 43/127 (33%), Gaps = 1/127 (0%) Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + + + GK L+ R L A GA V A + Q Sbjct: 235 DWFDRRALFGKHILVTRAADQAGGFSAQLEALGASVLEMPALVVTAPTSWEPLDRAIAQL 294 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +++TS ++ ++ + R+ L R+ V + A+ AR G V Sbjct: 295 AGYRWLLLTSANGVEAFFARLTHHRRDLRALGGVRVAAVGPKTAQAARTHGLICDFVPGQ 354 Query: 236 ADNDALL 242 +D LL Sbjct: 355 YVSDGLL 361 >UniRef50_A0QR19 Uroporphyrinogen-III synthase n=10 Tax=Actinomycetales RepID=A0QR19_MYCS2 Length = 610 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 83/251 (33%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R E+ RL T G + P I P + Q+ + L G + Sbjct: 342 TVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFT 401 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + ++ +G+ TA + L P + S LL Sbjct: 402 STNAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLD 461 Query: 118 LPELQNI---AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + R L+ R + E + + L RG E+ Y+ A Sbjct: 462 EFPPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMI 521 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V TS ++ L + + + + + + A+ A E G + + Sbjct: 522 KTGGFDAVCFTSSSTVRNLVGIAGKPH-----ARTIVACIGPKTAETAIEFGLRVDVQPE 576 Query: 235 NADNDALLRAL 245 A L+ AL Sbjct: 577 TAAVGPLVEAL 587 Score = 64.5 bits (156), Expect = 3e-09, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 33/128 (25%), Gaps = 7/128 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A E L LR G P ++ G D + S Sbjct: 475 RVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSS 534 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREIS---EVLLQL 118 V L K IG TA + + P+ + E L + Sbjct: 535 STVR----NLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVEALAEH 590 Query: 119 PELQNIAG 126 G Sbjct: 591 AARLRAEG 598 Score = 56.0 bits (134), Expect = 1e-06, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 32/122 (26%), Gaps = 3/122 (2%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMR 173 L E + + G L+ R + + L GA Sbjct: 330 LNWWESRALYGWTVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKG 389 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKV 232 VV TS ++ +W ++ + ++ V + A R G V Sbjct: 390 LVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELV 449 Query: 233 AD 234 Sbjct: 450 PS 451 >UniRef50_A5F4J2 Uroporphyrinogen-III synthase n=40 Tax=Vibrio RepID=A5F4J2_VIBC3 Length = 260 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 98/245 (40%), Positives = 129/245 (52%), Gaps = 5/245 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G EL L G A H PL+ S QL LA+ L D++ A+S Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAE---DLSSFDIIIAVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 QHAV F+ L + WP Y A+G+ TA Q + YP + SE LL L Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYP-EISDSEHLLALSM 121 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L+++AGK+ LILRGNGGRELI TL RGA V + E Y R + AE +WQ +V Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+TS E L + W+ LLV S+R+A LA +LG+ I V +A N Sbjct: 182 SLVITSSEQLAFFIRQFETSHLP-WVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAANRD 240 Query: 241 LLRAL 245 L+ AL Sbjct: 241 LVAAL 245 >UniRef50_C4DTF5 Uroporphyrinogen-III synthase; uroporphyrinogen-III C-methyltransferase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DTF5_9ACTO Length = 527 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 87/251 (34%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +L+ R E+ +LR G + P I P + Q+ + L G + Sbjct: 248 KVLIPRTKEQAGEMSDKLREYGAIPCEVPTIAVEPPRTPAQMERAIKGLVDGRYAWIVFT 307 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + + +G TA + + + L P + LL+ Sbjct: 308 SANAVKAIWEKFAEHGLDARAFGGLKIACVGDATAAKVRSFGIEPELLPTGEQSGTGLLE 367 Query: 118 LPELQNI---AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + + R L+ R + E + L RG EV Y+ A+ Sbjct: 368 VFPPHDTILDPVSRVLLPRADIATEALSAGLQERGWEVDDVTAYRTVRASPPPADIRDAI 427 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++ V+ TS ++ L + + + + V+ A+ A E G + Sbjct: 428 KSGGFDAVLFTSSSTVRNLVGIAGKPH-----ARTVVSVIGPHTAETATEFGLRVDAQPQ 482 Query: 235 NADNDALLRAL 245 +A+ +L+ AL Sbjct: 483 HANMPSLVEAL 493 Score = 59.5 bits (143), Expect = 1e-07, Method: Composition-based stats. Identities = 19/128 (14%), Positives = 34/128 (26%), Gaps = 4/128 (3%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQAR 177 E + + G + LI R + D L GA Sbjct: 240 ENRPLYGWKVLIPRTKEQAGEMSDKLREYGAIPCEVPTIAVEPPRTPAQMERAIKGLVDG 299 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVAD-N 235 +V TS ++ +W + + ++ V + A R G + + Sbjct: 300 RYAWIVFTSANAVKAIWEKFAEHGLDARAFGGLKIACVGDATAAKVRSFGIEPELLPTGE 359 Query: 236 ADNDALLR 243 LL Sbjct: 360 QSGTGLLE 367 Score = 53.7 bits (128), Expect = 5e-06, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 33/127 (25%), Gaps = 4/127 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R A E L + L+ G P G D + S Sbjct: 381 RVLLPRADIATEALSAGLQERGWEVDDVTAYRTVRASPPPADIRDAIKSGGFDAVLFTSS 440 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V L K IG TA + PQ + ++ L E Sbjct: 441 STVR----NLVGIAGKPHARTVVSVIGPHTAETATEFGLRVDAQPQHANMPSLVEALAEY 496 Query: 122 QNIAGKR 128 KR Sbjct: 497 AVALKKR 503 >UniRef50_C8NSF6 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=58 Tax=Actinomycetales RepID=C8NSF6_COREF Length = 626 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 93/253 (36%), Gaps = 15/253 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R P + +RL + G + P I P + Q+ + + G + Sbjct: 354 RVLVPRAKPQAAAMSARLASHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLT 413 Query: 60 SQHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLL 116 S +AV + + A+G TA + + L P +R+ ++ ++ Sbjct: 414 SVNAVRAVWDMITEFGLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPPRNRQNAQGIV 473 Query: 117 ----QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM 172 + E + G R L+ R + +++ D L A G EV Y+ A+ Sbjct: 474 DVFPEYIEELDPVG-RVLLPRADIATDVLVDGLVALGWEVDDVVAYRTVRAAPPSADIRD 532 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 + V TS ++ L + + + + + A ARELG + + Sbjct: 533 MIKTGGFDAVCFTSSSTVRNLVGIAGKPHP-----RTIIACIGPMTADTARELGLRVDVM 587 Query: 233 ADNADNDALLRAL 245 + A+ L+ AL Sbjct: 588 PEIAEVPDLVDAL 600 Score = 57.6 bits (138), Expect = 4e-07, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 37/119 (31%), Gaps = 3/119 (2%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQAR 177 E + + G R L+ R + L + GA Sbjct: 346 ENRALYGWRVLVPRAKPQAAAMSARLASHGAIPQEVPTISVEPPRNPAQMERAIKGIVEG 405 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADN 235 VV+TS ++ +W +I ++ + R+ V E+ A R LG + Sbjct: 406 RYQWVVLTSVNAVRAVWDMITEFGLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPPR 464 >UniRef50_C5S5J5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5J5_CHRVI Length = 251 Score = 203 bits (517), Expect = 4e-51, Method: Composition-based stats. Identities = 95/243 (39%), Positives = 131/243 (53%), Gaps = 7/243 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP+ E L + + G A FP I P A DLL+ +S + Sbjct: 12 VLVTRPAGQAEPLCRLIESAGGRAIRFPTIAIEPTHDPEATALLA---ESWDLLYFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV AQ+ + D WPR+ A+GR TA AL L P DR SE LL++PEL Sbjct: 69 AVEQAQALVA--DGTWPRVERVAAVGRGTARALEAAGRAPDLVPNDRYESEALLEMPELS 126 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 ++ G+R LI+RG GGR L ++ RGAEV F E Y+R D A W+ EV V Sbjct: 127 DMRGRRVLIVRGVGGRGLFAQAMSERGAEVRFAEVYRRARPAVDVAPLLAHWRE-EVDFV 185 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 + TS E+L L L+ Q + L L+V++ER A+ AR LG+Q I+VA+ AD+ +++ Sbjct: 186 MATSDEVLLNLAELLGQEGQASLL-ATPLVVIAERTAQTARNLGFQTIRVAERADDSSIV 244 Query: 243 RAL 245 RAL Sbjct: 245 RAL 247 Score = 47.2 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 19/121 (15%), Positives = 33/121 (27%), Gaps = 3/121 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIE-FSPGQQLPQLADQLAALGESDLLFALS 60 +L+ R + G + P + L E D + A S Sbjct: 132 RVLIVRGVGGRGLFAQAMSERGAEVRFAEVYRRARPAVDVAPLLAHWRE--EVDFVMATS 189 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + L Q+ + I TA + Q I + + S ++ L Sbjct: 190 DEVLLNLAELLGQEGQASLLATPLVVIAERTAQTARNLGFQTIRVAERADDSSIVRALIA 249 Query: 121 L 121 L Sbjct: 250 L 250 >UniRef50_D0WES9 Siroheme synthase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WES9_9ACTN Length = 548 Score = 203 bits (517), Expect = 4e-51, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 78/249 (31%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTR RL LG P I+ +P + L L AL + S Sbjct: 284 RILVTRSRTQASAFTRRLEALGAQVVEVPTIDIAPPESFDALDASLNALDGFSWVVFTSA 343 Query: 62 HAVAFAQSQLHQQ-----DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 + V +L ++ D + AIG TA AL + P + V Sbjct: 344 NGVEAFFERLRRRTALPHDARALAHARIAAIGPATADALRAHGIEADAVPHEYRAEAVFD 403 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + E A LI R RE + + L G VT Y+ Sbjct: 404 AMRERGLDADDAVLIPRAQVAREALPEMLAGIGCAVTVAPAYRTVVPGTSADAARAALAD 463 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 V V TS + L +L+ + L RL + LG+ A + Sbjct: 464 G-VDAVTFTSSSTAENLVALLGEDAP-ALLADARLFSIGPITTATLERLGFPPASTASSY 521 Query: 237 DNDALLRAL 245 L+ L Sbjct: 522 TIPGLVDTL 530 Score = 84.1 bits (207), Expect = 3e-15, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 50/161 (31%), Gaps = 6/161 (3%) Query: 92 ALALHTVSGQKILYPQDREIS--EVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARG 149 A + +++ L E + G+R L+ R L A G Sbjct: 246 ARRAEEAGFTAPVMTVVGQVACLREDLSWFEDAPLFGRRILVTRSRTQASAFTRRLEALG 305 Query: 150 AEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQ----WYREHW 205 A+V A +A + VV TS ++ + + + + Sbjct: 306 AQVVEVPTIDIAPPESFDALDASLNALDGFSWVVFTSANGVEAFFERLRRRTALPHDARA 365 Query: 206 LLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 L H R+ + A R G + V +A+ A++ Sbjct: 366 LAHARIAAIGPATADALRAHGIEADAVPHEYRAEAVFDAMR 406 >UniRef50_A3ETN4 Uroporphyrin-III C-methyltransferase / synthase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN4_9BACT Length = 516 Score = 203 bits (516), Expect = 5e-51, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 96/252 (38%), Gaps = 11/252 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLAALGESDLLFAL 59 IL+TR +G L L LG P IE P + ++ L L E + L L Sbjct: 263 RILLTREKESGSPLKDELEKLGAEVVSCPTIEIRPVTGMEREEVVRTLQNLSEYEWLLFL 322 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S + V + + + + F++G +T L P + + +L+ Sbjct: 323 SPNGVRYFFRAMRETGKDIRSLSGCRIFSMGPSTTRTLEEYGIHPDATPLESY-ANGVLE 381 Query: 118 LPELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG---AEEAMR 173 Q +G+R L++RG+ G I D L A G ++ Y+ + Sbjct: 382 FFRSQIPCSGQRCLLIRGDRGDGAIPDGLAAMGFKIQQITAYENRIPELPNYLRDLVSGG 441 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 ++ ++ + V S + L SL+ + + + L + A R+ G +I + Sbjct: 442 FENQDFHLAVFYSPSAYKNLVSLLKEHGQS--IRKTTGLAIGPTTADALRKDGVTNILLP 499 Query: 234 DNADNDALLRAL 245 ++A+L + Sbjct: 500 SEPTDEAVLTTI 511 Score = 69.9 bits (170), Expect = 7e-11, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 47/131 (35%), Gaps = 3/131 (2%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEAMRW 174 L+ + + + GKR L+ R + D L GAEV C + + + E Sbjct: 251 LEWQKNRPLFGKRILLTREKESGSPLKDELEKLGAEVVSCPTIEIRPVTGMEREEVVRTL 310 Query: 175 QA-REVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKV 232 Q E ++ S ++ + + + ++ L CR+ + + E G Sbjct: 311 QNLSEYEWLLFLSPNGVRYFFRAMRETGKDIRSLSGCRIFSMGPSTTRTLEEYGIHPDAT 370 Query: 233 ADNADNDALLR 243 + + +L Sbjct: 371 PLESYANGVLE 381 >UniRef50_A6C1N1 Uroporphyrin-III C-methyltransferase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C1N1_9PLAN Length = 509 Score = 203 bits (516), Expect = 5e-51, Method: Composition-based stats. Identities = 52/248 (20%), Positives = 89/248 (35%), Gaps = 4/248 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + I +TR E + + LG P IE S + ++ L L S Sbjct: 257 LRIGITRAEDQSETEIQQAIRLGAQPVLLPTIEISKPADQAPVDQAISRLEHYQWLVFTS 316 Query: 61 QHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V + +L + IG +TA AL + L P + +E L + Sbjct: 317 ANGVRYFMDRLWELGFDSRQLAHLKIATIGPSTAEALLAYRLRADLTPP-QYRAEALAEA 375 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + +A + L N GRE++ L A V Y+ + E ++ E Sbjct: 376 LKPL-VAHQSLLWAGANRGREVLQTELAKVSATVEKVVVYENHDVAAWNTESLRLLESGE 434 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V V ++S + + L+ R +L +S ++ A E G Q A + Sbjct: 435 VDWVGLSSPSIARNFERLLSDAARTQLGKSIKLASISPVTSQAALEAGLQIDAEAKDYHW 494 Query: 239 DALLRALQ 246 D + A+Q Sbjct: 495 DGIFAAIQ 502 Score = 59.1 bits (142), Expect = 1e-07, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 38/132 (28%), Gaps = 1/132 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 + E + + G R I R E GA+ + + + Sbjct: 246 IAWYEQKPLFGLRIGITRAEDQSETEIQQAIRLGAQPVLLPTIEISKPADQAPVDQAISR 305 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVAD 234 +V TS ++ + + + L H ++ + A+ + Sbjct: 306 LEHYQWLVFTSANGVRYFMDRLWELGFDSRQLAHLKIATIGPSTAEALLAYRLRADLTPP 365 Query: 235 NADNDALLRALQ 246 +AL AL+ Sbjct: 366 QYRAEALAEALK 377 >UniRef50_C7MKX3 Uroporphyrin-III C-methyltransferase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7MKX3_CRYCD Length = 579 Score = 203 bits (516), Expect = 6e-51, Method: Composition-based stats. Identities = 59/261 (22%), Positives = 90/261 (34%), Gaps = 18/261 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--------GESD 54 I+VTR L S L TLG FP I P + L L D Sbjct: 310 IVVTRSREQASVLSSGLSTLGAQVVEFPTIAIKPRSIDAHIRSALMRLASDAAHVRESYD 369 Query: 55 LLFALSQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREIS 112 + S + V + L++ AIG TA LH + P ++ I+ Sbjct: 370 WVVFTSANGVQCFFAALNELHLDARSLGGVKVAAIGPATAAELHNQGISPDVVP-EKFIA 428 Query: 113 EVLLQLPELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAE 169 E + Q + G R L+ R R+ + + LT GA+V Y + Sbjct: 429 ESVAQALVESGVGRGTRVLLPRAAVARDALPNRLTQAGAQVEVLPLYDTVIPHAEVAAQD 488 Query: 170 EAMRWQAREVTMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLAREL 225 A +A EV+ + TS ++ ++ P+ H L + + R+L Sbjct: 489 LATSLRAGEVSAITFTSSSTVRNFKEMLAAVMPESELIHLLETVTCASIGPVTSDTMRDL 548 Query: 226 GWQDIKVADNADNDALLRALQ 246 AD L+ ALQ Sbjct: 549 TIPVSVQADTHTIPGLISALQ 569 Score = 52.9 bits (126), Expect = 1e-05, Method: Composition-based stats. Identities = 20/135 (14%), Positives = 42/135 (31%), Gaps = 8/135 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFS-PGQQLPQLADQLA-ALGESDLLFAL 59 +L+ R + A + L +RL G PL + P ++ + GE + Sbjct: 445 RVLLPRAAVARDALPNRLTQAGAQVEVLPLYDTVIPHAEVAAQDLATSLRAGEVSAITFT 504 Query: 60 SQHAVAFAQSQLHQ-----QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S V + L + +IG T+ + ++ + D Sbjct: 505 SSSTVRNFKEMLAAVMPESELIHLLETVTCASIGPVTSDTMRDLTI-PVSVQADTHTIPG 563 Query: 115 LLQLPELQNIAGKRA 129 L+ + ++ Sbjct: 564 LISALQTALDKEEQL 578 >UniRef50_D1RC73 Uroporphyrinogen-III synthase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RC73_LEGLO Length = 252 Score = 202 bits (514), Expect = 9e-51, Method: Composition-based stats. Identities = 68/232 (29%), Positives = 106/232 (45%), Gaps = 4/232 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP +L +R G +A P +E D L L +S Sbjct: 8 LRILNTRPQEQAHKLTESIRASGGIAIELPALEIQ--ASNSDWVDLLPNLDNVTHAIFIS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +QL+Q WP AIG+ TA +L + Q P+ SE LL L Sbjct: 66 ANAVHYCFTQLNQLQINWPTSIQVIAIGQGTASSLQKFNIQVSAIPEFP-NSEHLLSLDT 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ + L+ +G GR LI + L +GA++ + YQR W+ V Sbjct: 125 LQHLENQNVLLFKGKEGRPLIEEQLMQKGAKLVILKVYQRVMPKPSPLLVQSIWRDDLVD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 ++++TS + L L+ + + WL R LV+SER+A++A LG I + Sbjct: 185 IILLTSEQSLLNLFKIFDKEA-HDWLKSKRWLVISERIAQIASSLGIHKINI 235 Score = 49.8 bits (118), Expect = 8e-05, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 46/121 (38%), Gaps = 3/121 (2%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +++ G R L R + +++ A G + A + D + VT Sbjct: 3 RSLNGLRILNTRPQEQAHKLTESIRASGGIAIELPALEIQASNSDWVDLLPNLDN--VTH 60 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + S + ++ + Q + +W +++ + + A ++ Q + + +++ L Sbjct: 61 AIFISANAVHYCFTQLNQL-QINWPTSIQVIAIGQGTASSLQKFNIQVSAIPEFPNSEHL 119 Query: 242 L 242 L Sbjct: 120 L 120 >UniRef50_C0N2Y5 Uroporphyrinogen-III synthase n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N2Y5_9GAMM Length = 250 Score = 202 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 114/244 (46%), Gaps = 9/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP ++L + G FP+I +P L ++ L +S+ Sbjct: 11 KILITRPRQQSDQLAELIEQAGGKPILFPVIAINPLL-PSDWQQPAFKLDHANWLIFVSR 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV S + P+ + A+G TA A+ + P+ SE LL +PE+ Sbjct: 70 NAVLSFMSGWQT---ELPKHLKFAAVGGGTAQAMRESGLKVDCQPEISSGSEGLLMMPEM 126 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q++A + +I+RG GGRE + DTL +RGA +++ E Y+R D A Sbjct: 127 QDVADCKIIIIRGVGGREHLADTLASRGASISYMEVYRRDVAVQDKVSIERAMAA---DK 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ TS + + ++ LL+ L+VVS R+ A G+ ++V+ +A + A+ Sbjct: 184 LICTSVAGIDNVCQILSD--DMTNLLNKPLVVVSNRIKAHAESKGFSCVRVSTDASDVAM 241 Query: 242 LRAL 245 L+ L Sbjct: 242 LQTL 245 Score = 51.0 bits (121), Expect = 4e-05, Method: Composition-based stats. Identities = 16/126 (12%), Positives = 42/126 (33%), Gaps = 6/126 (4%) Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + ++AG++ LI R + + + + G + + ++ Sbjct: 1 MVTEASLAGQKILITRPRQQSDQLAELIEQAGGKPILFPV-IAINPLLPSDWQQPAFKLD 59 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD-NA 236 ++ S + S ++ H + V A+ RE G + + ++ Sbjct: 60 HANWLIFVSRNAVLSFMS----GWQTELPKHLKFAAVGGGTAQAMRESGLKVDCQPEISS 115 Query: 237 DNDALL 242 ++ LL Sbjct: 116 GSEGLL 121 >UniRef50_B8F5M2 Uroporphyrinogen-III synthase n=10 Tax=Pasteurellaceae RepID=B8F5M2_HAEPS Length = 252 Score = 202 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 94/247 (38%), Positives = 132/247 (53%), Gaps = 3/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G +LV L A H PL G LP L L+ L D +FA+S Sbjct: 1 MNVLVTRPDQRGLQLVEMLAEQQIFAIHQPLFRVEAGADLPTLPSSLSRLNSGDYVFAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV FA L Q W YFA+G+ +A + Q + YP E SE LL LPE Sbjct: 61 KNAVDFATETLKQTGFYWRSDLLYFAVGQRSANHFASQIEQAVRYPIQSENSEGLLALPE 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + ++GK LILR + GRE + T+RGAEV ECY+R + + +E+ + Sbjct: 121 MAQLSGKNVLILRADTGREFFAEQATSRGAEVQILECYRRIMLADNLSEQISLAKRAGTD 180 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ--DIKVADNADN 238 +VVTSGE+L + WL CRL+VV +R+A LAR+ GW+ I+++ ADN Sbjct: 181 TIVVTSGEILTTFIEQTAEADLP-WLYQCRLIVVGKRIATLARKSGWKSEQIQISMKADN 239 Query: 239 DALLRAL 245 +LL + Sbjct: 240 HSLLETI 246 >UniRef50_A1TXW8 Uroporphyrinogen III synthase HEM4 n=3 Tax=Marinobacter RepID=A1TXW8_MARAV Length = 270 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 66/241 (27%), Positives = 107/241 (44%), Gaps = 3/241 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ RP P L R G A P++ P + P+ L L + A+S Sbjct: 18 RVLICRPEPEASRLAEAFRKAGADARVMPMMAREPLPETPEQRGILQQLDNFSHIIAVSP 77 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A ++ + P ++ +G TA + P + SE LL LP L Sbjct: 78 YAARRLMEEIDHWWPQLPAGLQWYGVGAGTAAVFREHGLKP-RMPAEGWTSEALLALPSL 136 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G++ L+ RG GRELI +TL RGA +T Y+R +Y + + Sbjct: 137 QRVDGEKVLLARGEHGRELIRETLAQRGARITTLPLYRRVLPYYSAKQVKALVADFHPEV 196 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V+ SGE L L L ++ L ++V +ER+A+ AR LG++ V + ++D L Sbjct: 197 VIALSGETLNNLVELGHRYQLA--LTPDIIVVPAERVAEQARALGFRKPLVPGSLNDDDL 254 Query: 242 L 242 + Sbjct: 255 V 255 Score = 59.9 bits (144), Expect = 7e-08, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 45/128 (35%), Gaps = 1/128 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 + + + G+R LI R + + GA+ R + + + Q Sbjct: 6 AEFQQPSELQGRRVLICRPEPEASRLAEAFRKAGADARVMPMMAREPLPETPEQRGILQQ 65 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + ++ S ++L I W+ + + V A + RE G + A+ Sbjct: 66 LDNFSHIIAVSPYAARRLMEEIDHWWPQ-LPAGLQWYGVGAGTAAVFREHGLKPRMPAEG 124 Query: 236 ADNDALLR 243 ++ALL Sbjct: 125 WTSEALLA 132 >UniRef50_Q180R8 Porphyrin biosynthesis protein includes: uroporphyrinogen-III methyltransferase and uroporphyrinogen-III synthase] n=12 Tax=Bacteria RepID=Q180R8_CLOD6 Length = 502 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 47/245 (19%), Positives = 88/245 (35%), Gaps = 5/245 (2%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 I VTR LV ++ LG P I+ Q L +++ + + + L S++ Sbjct: 258 IAVTRSRNQNSVLVEKIMDLGGNPIEIPTIKVEKIQNNINLENEIKNINKYNYLILTSKN 317 Query: 63 AVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV ++++ + AIG T+ L + P+ ++E L + Sbjct: 318 AVEIFFEKIYEMNFDLRILSNLKVCAIGSATSNELKKRGIIADIVPKK-FVAESLYEELA 376 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LI R R+ + D L A EVT Y+ E + ++ Sbjct: 377 PILNDDDNILIPRAENARDYLVDKLKAI-CEVTEVHIYRTVIDEEKKGEILDILNSNDID 435 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + TS + L +I + L + L + + LG + K + + D+ Sbjct: 436 YITFTSSSTVNNLVEIIGKENI-KILEKIKTLSIGPITTETINSLGIKLYKESATSTIDS 494 Query: 241 LLRAL 245 L+ + Sbjct: 495 LVDLI 499 >UniRef50_A6CN70 HemD n=1 Tax=Bacillus sp. SG-1 RepID=A6CN70_9BACI Length = 266 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 86/242 (35%), Gaps = 3/242 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTR A + + ++ G + PLI F P + + + L L D +F S++ Sbjct: 12 ILVTREEKAAKGIADVIKQYGGIPHIVPLISFRPYEDEKE-STYLEKLKSYDWIFFTSKN 70 Query: 63 AVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V F +L + + P + A+G T A+ + Q P+ + Sbjct: 71 GVHFFFQKLKEHNLSIVGSPTKFAAVGEKTCRAMKSHGIQVDFVPKL-YSGFDFAKEFVH 129 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 R L+ +GN ++ I T R + Y+ + Q ++++ Sbjct: 130 SFPQAGRVLLSKGNLAKDTISSYFTERSMPIDEWITYETFFPDAIEKRLSSLLQEKKLSA 189 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ ++ + ++ + + A G V + + + Sbjct: 190 VTFTSPSTVRGFMKIVNDNGLHEAMNGLAVVCIGPVTREAACRYGLTVQVVPERYTVEDM 249 Query: 242 LR 243 + Sbjct: 250 ID 251 >UniRef50_Q59294 Uroporphyrinogen-III synthase n=6 Tax=Clostridium RepID=HEM4_CLOJO Length = 504 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 87/246 (35%), Gaps = 8/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP + LV +LR LG +P IE P Q +L + E + S+ Sbjct: 255 KILVTRPKESSGTLVEKLRQLGAEPVEYPCIEVVPIPQNEKLYHACENIREYGWILLTSK 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + + L+ + +G TA AL V P + L Sbjct: 315 NGIQIFFDYLNSKGLDARVLANTKIGTVGSQTAKALKEVGLISDFTP-EIFDGRHLALGI 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + ++ LI + I + L + + Y I+ + + E+ Sbjct: 374 AERVGENEKVLICDAAIASDDIVNILRSNNIKFDRVPLYNTNYINENSNKVKKSIVHGEL 433 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + TS ++ + + L + + + A+ A++ + + VA+ + D Sbjct: 434 KYITFTSASTVEGFIASMKDIP----LESLTAVCIGNKTAEAAKKYNLRYV-VAEKSTID 488 Query: 240 ALLRAL 245 +++ L Sbjct: 489 SMIDKL 494 Score = 65.3 bits (158), Expect = 2e-09, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 42/117 (35%), Gaps = 1/117 (0%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 G + L+ R + + L GAE C + I + RE +++T Sbjct: 253 GTKILVTRPKESSGTLVEKLRQLGAEPVEYPCIEVVPIPQNEKLYHACENIREYGWILLT 312 Query: 186 SGEMLQQLWSLIPQWYREHW-LLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 S +Q + + + L + ++ V + AK +E+G + D L Sbjct: 313 SKNGIQIFFDYLNSKGLDARVLANTKIGTVGSQTAKALKEVGLISDFTPEIFDGRHL 369 >UniRef50_B7VME0 Uroporphyrinogen-III synthase n=14 Tax=Vibrionales RepID=B7VME0_VIBSL Length = 242 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 99/246 (40%), Positives = 137/246 (55%), Gaps = 5/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTRP G+ L +L G A H PLI L+ L SD++ A+S Sbjct: 1 MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLST---QLNNSDIIIAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 HAV AQ+ L + WP P Y +G+ TA L VS QK+ YP+ SE LL+L E Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPK-VSDSEHLLKLTE 116 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + K LILRGNGGRELI D+L RGA+V++CE Y+R I + W ++ + Sbjct: 117 LNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKTS 176 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV+TS E L+ L S+ P Y WL +L V S+R+ + A++LG+ ++ +A N Sbjct: 177 KVVITSQEQLEYLCSITPDEYL-AWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQI 235 Query: 241 LLRALQ 246 LL ALQ Sbjct: 236 LLAALQ 241 >UniRef50_Q9K8G1 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus halodurans RepID=Q9K8G1_BACHD Length = 253 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 46/243 (18%), Positives = 87/243 (35%), Gaps = 8/243 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+TR L + G V PL+ F + A++ + + S + Sbjct: 11 VLITRAKEQASSLSRLIEEAGGVPIEVPLLSFIKTMD--VYEEVGASIQSYEWIVFTSAN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV F + ++ +LP A+G +T L L P + ++E L++ + Sbjct: 69 AVRFFFNTWP--RQELKKLPSIAAVGSSTQRELSRYGISVDLMPNE-YVAESLVETMVKR 125 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + R L +GN R + L G V Y+ +Q + ++ Sbjct: 126 -LKPCRVLFPKGNLARPTVKVGLETNGFIVDEMTVYETKRPLEAKVMLCEAFQKHRIEII 184 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 TS + +L+ + + H H + A A++ G VA + L+ Sbjct: 185 TFTSPSAVDHFVTLLDREFILH--EHLLYAYIGPIAAARAKQRGLPVHIVAKTYTGEGLV 242 Query: 243 RAL 245 A+ Sbjct: 243 NAI 245 Score = 52.5 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 15/127 (11%), Positives = 33/127 (25%), Gaps = 5/127 (3%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + GK LI R + + G E Q Sbjct: 1 MIAPVLKGKGVLITRAKEQASSLSRLIEEAGGVPIEVPLLSFIKTMDVYEEVGASIQ--S 58 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +V TS ++ ++ P+ + + V + G + + Sbjct: 59 YEWIVFTSANAVRFFFNTWPRQELKKLPS---IAAVGSSTQRELSRYGISVDLMPNEYVA 115 Query: 239 DALLRAL 245 ++L+ + Sbjct: 116 ESLVETM 122 >UniRef50_A9B548 Uroporphyrinogen III synthase HEM4 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B548_HERA2 Length = 266 Score = 200 bits (508), Expect = 4e-50, Method: Composition-based stats. Identities = 51/249 (20%), Positives = 87/249 (34%), Gaps = 9/249 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++TR E L G + I+ P L+ + D + A S Sbjct: 11 RIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMIATST 70 Query: 62 HAVAFAQSQLHQQDRK--WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV + AIG+ TA L P ++E L Sbjct: 71 NAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVP-HAYVAEQFL--V 127 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E Q+IAG+R + + + R L+ + L RGA+VT Y+ A A + + V Sbjct: 128 EFQDIAGQRIFLPQADIARPLLREALIERGADVTAVVAYRTVPDPQVVA-LAELLRQQRV 186 Query: 180 TMVVVTSGEMLQQLWSLIPQWY---REHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +V TS ++ + + +L + + ++ A ++G A Sbjct: 187 DVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVDIEAAEH 246 Query: 237 DNDALLRAL 245 L+ AL Sbjct: 247 STQGLVEAL 255 Score = 62.9 bits (152), Expect = 9e-09, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 35/115 (30%), Gaps = 1/115 (0%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GKR ++ R L GAE +C Q + Q + Sbjct: 6 PLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWM 65 Query: 183 VVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + TS ++ + + L ++ + + AKL + G V Sbjct: 66 IATSTNAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAY 120 Score = 55.2 bits (132), Expect = 2e-06, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 32/113 (28%), Gaps = 5/113 (4%) Query: 15 LVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQ 74 L L G P Q+ LA+ L D++ S V + LH Sbjct: 149 LREALIERGADVTAVVAYRTVPDPQVVALAELLRQ-QRVDVVTFTSSSTVRYTIEALHAA 207 Query: 75 D----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 +++ IG T+ V + + ++ L E Sbjct: 208 GMRNSQEFLNQTIIATIGPITSQTALDVGLHVDIEAAEHSTQGLVEALLEWAK 260 >UniRef50_Q479S9 Uroporphyrinogen-III synthase n=3 Tax=Betaproteobacteria RepID=Q479S9_DECAR Length = 260 Score = 199 bits (506), Expect = 7e-50, Method: Composition-based stats. Identities = 79/246 (32%), Positives = 114/246 (46%), Gaps = 5/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP L + G FPL+E SP L + +A L L +S Sbjct: 11 TIVVTRPQAQAAPLAEAIAAAGGKPLVFPLLEISPATDPQPLIEAVARLESYSLAVFISP 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV A + WP A+G+ TA L + P +R SE LL+LPE+ Sbjct: 71 NAVDHALPAILAHG-GWPVSLKPAAVGQGTARELAAKGVFGCVVPSERFDSEALLELPEM 129 Query: 122 QN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G+R +I RG+GGREL+ DTL RGA V CY+R WQ+ ++ Sbjct: 130 AAESVNGRRVVIFRGDGGRELLADTLRERGASVDCITCYRRSGPSAGVQPLLAAWQSGQL 189 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + V+S E L+ L + R +L L V R+A+ AR LG +I + + AD Sbjct: 190 DALTVSSSEGLRYLVDRLDAEGR-AFLQKTPLFVPHARIAENARALGLSNIILTEAAD-A 247 Query: 240 ALLRAL 245 +L L Sbjct: 248 GILAGL 253 >UniRef50_A7Z7A4 HemD n=1 Tax=Bacillus amyloliquefaciens FZB42 RepID=A7Z7A4_BACA2 Length = 259 Score = 199 bits (506), Expect = 7e-50, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 73/244 (29%), Gaps = 2/244 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR ++ LG A LI F L E L S Sbjct: 11 TVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLSEPGWLVFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V F S L + A+G TA AL + P + ++E L + Sbjct: 71 NGVRFFFSYLDRHGLALSGRKKIAAVGEKTARALKERGARTDAMPDE-YVAECLADTLKR 129 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 A + +++GN R++I L G ++ Y E Sbjct: 130 YASAAEPISVIKGNLSRDVIKAELEPLGYQIREWVLYNTIQDEKGMDELRRAASRSHFDF 189 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + TS + + + + + K E G V D + + Sbjct: 190 ITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISS-HVPDTYTIEGM 248 Query: 242 LRAL 245 L + Sbjct: 249 LDVM 252 Score = 55.6 bits (133), Expect = 1e-06, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 40/126 (31%), Gaps = 5/126 (3%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR--EVT 180 + GK L+ R + A G E A + E Sbjct: 6 PLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASL--IAFQEALPDECADSLREDLSEPG 63 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS ++ +S + + ++ V E+ A+ +E G + + D + Sbjct: 64 WLVFTSVNGVRFFFSYLDRHGL-ALSGRKKIAAVGEKTARALKERGARTDAMPDEYVAEC 122 Query: 241 LLRALQ 246 L L+ Sbjct: 123 LADTLK 128 >UniRef50_C1YGP0 Uroporphyrinogen-III synthase; uroporphyrinogen-III C-methyltransferase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YGP0_NOCDA Length = 562 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 85/253 (33%), Gaps = 13/253 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R L +LR G V P I P + Q+ + L G + Sbjct: 284 RVLVPRTKEQAAALSDQLRGYGAVPEEVPTISVEPPRTPQQMERAVRGLVTGRYQWVAFT 343 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDRE-ISEVLL 116 S +AV + +L +G TA A+ Q L P + E S L+ Sbjct: 344 SVNAVRAIRERLESYGLDARAFAGVKVAVVGEATARAVREFGIQPDLAPPEEEQSSSGLV 403 Query: 117 QLPELQNI---AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 + + +R L+ R + E + L G EV Y+ A Sbjct: 404 SVWPPYDAEIDPIERVLLPRADIATETLSAGLDKLGWEVDDVTAYRTVRAAPPPAPVREA 463 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + V+ TS ++ L + + + + V+ + A E G + VA Sbjct: 464 IKGGGFDAVLFTSSSTVRNLVGIAGKPH-----NTTVIAVIGPETERTAIEFGLRVDVVA 518 Query: 234 DNADNDALLRALQ 246 A AL +AL Sbjct: 519 PKASVSALAQALS 531 Score = 59.1 bits (142), Expect = 1e-07, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 42/148 (28%), Gaps = 11/148 (7%) Query: 91 TALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGA 150 TA AL V +P+ L E + + G R L+ R + D L GA Sbjct: 255 TAPALMVVGPAAGRHPE--------LSWYESRPLFGWRVLVPRTKEQAAALSDQLRGYGA 306 Query: 151 EVTFCECYQRCAI--HYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH-WLL 207 V TS ++ + + + + Sbjct: 307 VPEEVPTISVEPPRTPQQMERAVRGLVTGRYQWVAFTSVNAVRAIRERLESYGLDARAFA 366 Query: 208 HCRLLVVSERLAKLARELGWQDIKVADN 235 ++ VV E A+ RE G Q Sbjct: 367 GVKVAVVGEATARAVREFGIQPDLAPPE 394 >UniRef50_P21248 Uroporphyrinogen-III synthase n=4 Tax=Bacillus RepID=HEM4_BACSU Length = 262 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 73/244 (29%), Gaps = 2/244 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTR ++ LG A LI F L L S Sbjct: 11 TVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + F S L + P A+G TA L + + PQ+ I+E L + Sbjct: 71 NGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQE-YIAEQLADALKQ 129 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ +++GN R++I L G EV Y+ Sbjct: 130 HAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKDAAGQYSFDY 189 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS + ++ + ++ + + G D D + Sbjct: 190 VTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITS-HTPDTFTIDGM 248 Query: 242 LRAL 245 L + Sbjct: 249 LELM 252 Score = 59.1 bits (142), Expect = 1e-07, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 42/126 (33%), Gaps = 5/126 (3%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARG--AEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + GK L+ R + A G A +T ++R + + A Sbjct: 6 PLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAA--PG 63 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS +S + + + H ++ V E+ A+ + + + Sbjct: 64 WLVFTSVNGADFFFSYLKE-NQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQ 122 Query: 241 LLRALQ 246 L AL+ Sbjct: 123 LADALK 128 >UniRef50_A4BS89 Uroporphyrinogen III synthase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS89_9GAMM Length = 267 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 81/246 (32%), Positives = 111/246 (45%), Gaps = 4/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRP+ E L G A PL+ S + P A A L DLL S Sbjct: 17 NIVVTRPAHQAESFCRMLEHAGANALRCPLLNISATPKTPSFARLRAELASFDLLIFNSP 76 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A F QL R+ AIG TA A+ + + P SE LL+LP L Sbjct: 77 NAANFGLPQLEP-QRRLQGRVKIAAIGAKTAHAIAGLGYSVDIVPATGFDSESLLELPIL 135 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG-AEEAMRWQAREVT 180 + + G + ILRG+GGREL G L +RGAEV++ + Y+R + + Sbjct: 136 EKVGGMKIAILRGSGGRELAGSVLRSRGAEVSYIQVYERQPPSKEQFEQIEQLLLHNRSD 195 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW-QDIKVADNADND 239 V +TSGE LWS I H L + S R+A +AR G I VA + ++ Sbjct: 196 AVAITSGEAFLALWSGIGPR-LCHLLNQSTFVFGSRRIADVARSKGLCSPIAVAADPSDE 254 Query: 240 ALLRAL 245 A+ AL Sbjct: 255 AMFAAL 260 >UniRef50_A6W1B5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Marinomonas sp. MWYL1 RepID=A6W1B5_MARMS Length = 250 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 112/246 (45%), Gaps = 10/246 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQL---PQLADQLAALGESDLLFA 58 IL+TRP P R+R G VA P++E P + + + Q+ + D + Sbjct: 5 RILITRPEPENSLSRERVRAYGWVAVPLPMLEIKPVEDVNKKATIRAQIFDIDTFDYVIF 64 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +S++A A L + P + IG+ T L I P +E LL+ Sbjct: 65 VSKNAARLACDWLDECWPMIPTNVHWIGIGQGTTQTLLNEGIPAISNP--GHTTETLLEW 122 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + ++ LI+RG GGR + + L RGA+V++ Y R Y + + Sbjct: 123 LKPAKMKDQKVLIIRGEGGRPELANKLEERGAKVSYLSLYDRKKPIYYAQTF---FMLPD 179 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + ++ +TSGE L+ L + E +L S R+ + A+E+GW + A+ AD+ Sbjct: 180 INLIWITSGESLRNLSEYVSLHKPE--WKTLPILTPSIRVNQQAKEMGWINASCANGADD 237 Query: 239 DALLRA 244 ++L++A Sbjct: 238 NSLIKA 243 >UniRef50_C8WIZ1 Uroporphyrin-III C-methyltransferase n=10 Tax=Bacteria RepID=C8WIZ1_EGGLE Length = 522 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 76/250 (30%), Gaps = 7/250 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++ VTR L RLR LG P+I + + + L + S Sbjct: 263 TVAVTRTRAQASGLTERLRALGASVIELPVISIAAPSSFSGVDSCIERLAGYRFVVFTSA 322 Query: 62 HAVAFAQSQLHQQDRKWPRLP--DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L L AIG TA L L P + +E + L Sbjct: 323 NGVKAFFERLVLAGLDARALACARIAAIGPATAAELAERGIVADLVPGE-FRAEAVADLL 381 Query: 120 ELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-YDGAEEAMRWQAR 177 + G L+ R R+++ L A GA V Y+ A Sbjct: 382 IEAGLTDGDWVLVPRALEARDVLPRMLRACGARVDVVPVYRTVPPSRASAEPALASLIAG 441 Query: 178 EVTMVVVTSGEMLQQLWSLIPQ--WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 E V TS ++ L+ L + AR+ + A+ Sbjct: 442 EADAVTFTSSSTVRNFVGLVRDVAPNPVEVLERLDFYSIGPITTTTARDESLRIAAQAEA 501 Query: 236 ADNDALLRAL 245 D L+ A+ Sbjct: 502 YTIDGLVEAI 511 Score = 61.0 bits (147), Expect = 3e-08, Method: Composition-based stats. Identities = 29/179 (16%), Positives = 48/179 (26%), Gaps = 23/179 (12%) Query: 68 QSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGK 127 + K P + A+ AL L E +AG Sbjct: 225 AERAAAVGFKAPAIIVVGAV-----AALRER-----------------LAWYEPGPLAGT 262 Query: 128 RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSG 187 + R + + L A GA V A ++ + VV TS Sbjct: 263 TVAVTRTRAQASGLTERLRALGASVIELPVISIAAPSSFSGVDSCIERLAGYRFVVFTSA 322 Query: 188 EMLQQLWSLIPQWYREHWLLHC-RLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 ++ + + + L C R+ + A E G V +A+ L Sbjct: 323 NGVKAFFERLVLAGLDARALACARIAAIGPATAAELAERGIVADLVPGEFRAEAVADLL 381 >UniRef50_Q1INI7 Uroporphyrinogen-III synthase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=Q1INI7_ACIBL Length = 272 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 88/249 (35%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LV+R L L+ G P IE Q + + ++ + D L S Sbjct: 17 RVLVSRARKQAGALSVELKARGARVLEIPFIEIREPQSFAPMDTAIRSVLDYDWLILTSV 76 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V +L + AIG T A+ + + P++ ++E +++ Sbjct: 77 NGVNALFRRLEKLKLRPDLFEKLKIAAIGPATKKAIEGQRLKVEVTPKE-YVAEAVVEAL 135 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA--R 177 + + GKR L++R R++I + L GA V E Y+ + + + Sbjct: 136 -ARKVKGKRVLLVRAKVARDVIPNELRRAGANVDVVEAYETVVPEKSRGKLSDALHSLKN 194 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLH-CRLLVVSERLAKLARELGWQDIKVADNA 236 + ++ TS ++ LI + R + + RE A+ Sbjct: 195 KPQVITFTSSSTVKNFVELIGKRAATKCFRDGVRSASIGPVTSATLREFNLPVNIQAEEY 254 Query: 237 DNDALLRAL 245 L+ A+ Sbjct: 255 TIPGLVAAI 263 Score = 66.4 bits (161), Expect = 8e-10, Method: Composition-based stats. Identities = 21/142 (14%), Positives = 43/142 (30%), Gaps = 8/142 (5%) Query: 105 YPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH 164 P + +E L + G R L+ R + L ARGA V + Sbjct: 1 MPSRSKPAETL-------PLKGVRVLVSRARKQAGALSVELKARGARVLEIPFIEIREPQ 53 Query: 165 YDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWY-REHWLLHCRLLVVSERLAKLAR 223 + + +++TS + L+ + + R ++ + K Sbjct: 54 SFAPMDTAIRSVLDYDWLILTSVNGVNALFRRLEKLKLRPDLFEKLKIAAIGPATKKAIE 113 Query: 224 ELGWQDIKVADNADNDALLRAL 245 + +A++ AL Sbjct: 114 GQRLKVEVTPKEYVAEAVVEAL 135 >UniRef50_A7BY77 Uroporphyrinogen III synthase HEM4 n=1 Tax=Beggiatoa sp. PS RepID=A7BY77_9GAMM Length = 271 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 77/268 (28%), Positives = 120/268 (44%), Gaps = 31/268 (11%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + ILVTRP+ E L + G + P+IE + L D L E D+ +S Sbjct: 6 IKILVTRPAHQAEHLCQLIEAEGGQSIRLPVIEIIDIEDKTALFDCRMHLDELDIAIFIS 65 Query: 61 QHAVAFAQSQLHQQD--------------------RKWPRLPDYFAIGRTTALALHTVSG 100 +AV + L + ++ + A+G+ T L Sbjct: 66 ANAVDKSLPTLLTPNHSENEKDSLTPVSTNSTTYFQREEQTLQIIAVGKRTTSTLKAWGL 125 Query: 101 QKILYPQDREISEVLLQLPELQN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECY 158 L P SE +L++P++Q + GK+ +I RG GGREL+ +TL RGA V + Y Sbjct: 126 T-ALCPDSPFNSEAVLKMPQMQTEVVQGKKIVIFRGEGGRELLAETLQQRGAIVNYINVY 184 Query: 159 QRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERL 218 +R V ++ VTS E LQ L++++ + + WL H +V+SER+ Sbjct: 185 RRIQPSVP-----KWIADISVDVITVTSIEGLQNLFAMLEK--QVAWLCHTPFVVMSERI 237 Query: 219 AKLARELGWQ-DIKVADNADNDALLRAL 245 A++LG Q I VA A +D LL A+ Sbjct: 238 RTEAQKLGVQAPIFVAPTASDDGLLTAI 265 >UniRef50_Q2JFR9 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=3 Tax=Frankia RepID=Q2JFR9_FRASC Length = 607 Score = 196 bits (498), Expect = 6e-49, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 91/251 (36%), Gaps = 12/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 ++LV R L LR+ G P I P + + + L G + Sbjct: 332 TVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFT 391 Query: 60 SQHAVAFAQSQLHQ--QDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV Q ++ + D + AIG TA AL T + L P ++ SE LL Sbjct: 392 SVNAVKAVQEKVEERSLDARAFAGVKVAAIGEATADALRTFGIRPDLVPSGQQSSEGLLA 451 Query: 118 ---LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + R L+ R + E + L RG +V Y+ A Sbjct: 452 DWPDFDDTLDLLDRVLLPRADIATETLVAGLKERGWQVDDVTAYRTVRAAPPPASIREAL 511 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + V VV TS ++ L + + + + V+ A A+ELG + A Sbjct: 512 KGGRVDAVVFTSSSTVRNLVGIAGKPH-----ETTVIAVIGPATAATAQELGLRVDVQAP 566 Query: 235 NADNDALLRAL 245 A AL+ AL Sbjct: 567 EASIPALVGAL 577 Score = 59.9 bits (144), Expect = 8e-08, Method: Composition-based stats. Identities = 19/132 (14%), Positives = 38/132 (28%), Gaps = 4/132 (3%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAEEAMR 173 L E + + G L+ R ++ D L + GA Sbjct: 320 LSWWETRALFGWTVLVPRTKEQAAILSDLLRSHGASPLEVPTIAVEPPRTAAPMERAITG 379 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKV 232 + V TS ++ + + + + ++ + E A R G + V Sbjct: 380 LVSGRYQWVAFTSVNAVKAVQEKVEERSLDARAFAGVKVAAIGEATADALRTFGIRPDLV 439 Query: 233 AD-NADNDALLR 243 ++ LL Sbjct: 440 PSGQQSSEGLLA 451 >UniRef50_Q1MZM6 Uroporphyrinogen-III synthetase n=1 Tax=Bermanella marisrubri RepID=Q1MZM6_9GAMM Length = 255 Score = 196 bits (498), Expect = 6e-49, Method: Composition-based stats. Identities = 76/251 (30%), Positives = 120/251 (47%), Gaps = 12/251 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPG-----QQLPQLADQLAALGESDLLF 57 +LVTRP G+ ++ L G H PL++ P QL ++ L D + Sbjct: 4 LLVTRPQGQGQGMMIELEQAGIQVVHQPLLKIEPLKMEDGADYHQLKQRIVDLDLYDTVI 63 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTV--SGQKILYPQDREISEVL 115 +S +A A + Q + P +FA+G ++A L + S + + SE L Sbjct: 64 CVSSNAAQLASDWIDQYWPQLPVKQQWFAVGPSSAEPLLPLLDSAAMDIQVPEGNHSEGL 123 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L LP+L+++ K+ LILRG GGRELI TL RGA V + E Y+R + + Sbjct: 124 LALPQLRDMTEKKVLILRGVGGRELIKSTLEERGASVHYAEFYRRTPVDLTQQQLQTLLT 183 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 ++ ++TSGEM+QQ +P LLV SER+ K+A +LG+Q + Sbjct: 184 EHQIHYALLTSGEMVQQFHQALPNTP-----KDLHLLVPSERIQKMAIDLGFQQTHICQP 238 Query: 236 ADNDALLRALQ 246 A+L+++ Sbjct: 239 ITAQAVLKSIN 249 >UniRef50_Q1YSU1 Uroporphyrinogen-III synthetase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSU1_9GAMM Length = 243 Score = 196 bits (498), Expect = 7e-49, Method: Composition-based stats. Identities = 81/245 (33%), Positives = 122/245 (49%), Gaps = 8/245 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILV RP ++ + L G H P++ P + + + + D +S Sbjct: 4 RILVIRPLRQADQFIELLERAGNQVCHIPVMAIEPVVDGQSIKNLILEVDNFDKAICVSG 63 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A A L + P +YFAIG+ TA L L P R+ SE LL LPEL Sbjct: 64 NAAELAIEWLDRYWPMQPVGIEYFAIGQQTAHILGAADI-VALSPSGRQNSEALLALPEL 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q+++ +R ++ RG GGRE++GDTL RGA V +CE Y+R R Q E Sbjct: 123 QDLSDQRVIVFRGRGGREILGDTLIERGARVDYCELYERVINPQ--KALLARKQMLESDC 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +V SGE+L L + E ++V SER+A++A +LG+++I A+NA +A+ Sbjct: 181 LVAHSGELLTALGDQSGESGAE-----TAVVVPSERVAEIAWKLGYRNIVSAENALPEAM 235 Query: 242 LRALQ 246 L A+Q Sbjct: 236 LAAVQ 240 Score = 40.2 bits (93), Expect = 0.069, Method: Composition-based stats. Identities = 12/118 (10%), Positives = 39/118 (33%), Gaps = 1/118 (0%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 +R L++R + + L G +V + + + + + + Sbjct: 2 SQRILVIRPLRQADQFIELLERAGNQVCHIPVMAIEPVVDGQSIKNLILEVDNFDKAICV 61 Query: 186 SGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 SG + + +++ + + ++ A + + + +++ALL Sbjct: 62 SGNAAELAIEWLDRYWPMQPV-GIEYFAIGQQTAHILGAADIVALSPSGRQNSEALLA 118 >UniRef50_A0L5L4 Uroporphyrinogen-III synthase n=1 Tax=Magnetococcus sp. MC-1 RepID=A0L5L4_MAGSM Length = 259 Score = 196 bits (498), Expect = 7e-49, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 88/244 (36%), Gaps = 3/244 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTRP P + + G P++ +P + L +AA+ D + S Sbjct: 10 TILVTRPQPEADATALLILQAGGTPIITPMLNIAPAEDSQPLQQAIAAIHSFDGVLITSA 69 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A L Q + P FA+G TA L G + P R E L + Sbjct: 70 NAARAYLDALAAQAQPLSGTPPCFAVGPKTAELLRA-GGATVCQPSSRFDGEALAEAINQ 128 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ L R GRE + D L VT Y+ A+ + + V Sbjct: 129 WQGKGRHFLFPRAAIGRETLIDGLENDDHRVTMVAAYRALPAQQLSAQAHRYLREKRVDA 188 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + S + L+ E L +S A+ LG+ +A A ++L Sbjct: 189 ALFFSSRTATTFFELLISQALEPA--EMVLAALSPVTAERMASLGFAAHVIAPQATAESL 246 Query: 242 LRAL 245 L+AL Sbjct: 247 LQAL 250 Score = 46.4 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 26/88 (29%), Gaps = 2/88 (2%) Query: 160 RCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERL 218 A D A V++TS + + + V + Sbjct: 41 NIAPAEDSQPLQQAIAAIHSFDGVLITSANAARAYLDALAAQAQP-LSGTPPCFAVGPKT 99 Query: 219 AKLARELGWQDIKVADNADNDALLRALQ 246 A+L R G + + D +AL A+ Sbjct: 100 AELLRAGGATVCQPSSRFDGEALAEAIN 127 >UniRef50_C1PAG5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Bacillus coagulans 36D1 RepID=C1PAG5_BACCO Length = 262 Score = 196 bits (498), Expect = 8e-49, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 83/245 (33%), Gaps = 3/245 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL+TR GE+L +++ LG + P++ F L + L L D + S+ Sbjct: 11 NILITRGGKDGEKLAAQIEALGGTPFVVPMVSFRAYADLSA-SVFLRKLSAYDWVVFTSK 69 Query: 62 HAVAFAQSQLHQQDRKWPR-LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V + + ++ A+G+ TA + + P+ ++ + Sbjct: 70 NGVRYFLEACSRAGIACEHLNINWAAVGKKTAACMEQSGLKVSFAPRK-FTAKDFAREFL 128 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 R L+ +GN I D L G Y+ + + Sbjct: 129 RSGHRASRVLLPKGNLAGTEIADFLRKSGIIAEEWIVYETYMPEGAKEKLTRLLGREHID 188 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + S + + + + L R+ V+ + + G + D +A Sbjct: 189 FALFLSPSAFRHFKGALEESGMDIAGLSTRIAVIGPSTRQAVEKAGSRAAVCPDEYTVEA 248 Query: 241 LLRAL 245 +L AL Sbjct: 249 MLGAL 253 >UniRef50_D2R7V5 Uroporphyrin-III C-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R7V5_9PLAN Length = 505 Score = 195 bits (497), Expect = 9e-49, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 89/246 (36%), Gaps = 9/246 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP+ E L L LG P I + L + L D L S Sbjct: 260 TVLVTRPAQQAESLARPLEELGAAVLLDPAIVIGMPEDSAPLVQAIHTLETYDWLVFASA 319 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V QL +G T+ AL + + L P++ E +E L + Sbjct: 320 SGVEKFFEQLISLGYDLRKLAHIRLAVVGSGTSAALEKLHLRADLVPENFE-AESLAAML 378 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + AGKR LI+R + GRE++ L GA V Y+ R R++ Sbjct: 379 APEA-AGKRVLIVRASRGREVLPQLLANSGAGVEQVVAYESVDNLVPDPLVVQRLTERKI 437 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + VTS + L + L +L +S + R LG + A Sbjct: 438 DYISVTSSAIATSLVNRYGD-----LLRSAKLASLSPITSATIRSLGHEVAVEATLYTMA 492 Query: 240 ALLRAL 245 L+ A+ Sbjct: 493 GLVEAI 498 Score = 64.1 bits (155), Expect = 4e-09, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 49/160 (30%), Gaps = 9/160 (5%) Query: 92 ALALHTVSGQK--ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARG 149 A + + + + L + + + G L+ R E + L G Sbjct: 222 AQFVKQTGLRPPVVFIVGEVVNLRDELTWFDRRPLFGTTVLVTRPAQQAESLARPLEELG 281 Query: 150 AEV--TFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYRE-HW 205 A V + D A +V S +++ + + + Sbjct: 282 AAVLLDPAIV---IGMPEDSAPLVQAIHTLETYDWLVFASASGVEKFFEQLISLGYDLRK 338 Query: 206 LLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 L H RL VV + +L + V +N + ++L L Sbjct: 339 LAHIRLAVVGSGTSAALEKLHLRADLVPENFEAESLAAML 378 >UniRef50_A4A9F8 Uroporphyrinogen-III synthase n=3 Tax=unclassified Gammaproteobacteria RepID=A4A9F8_9GAMM Length = 261 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 72/235 (30%), Positives = 117/235 (49%), Gaps = 3/235 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLP-QLADQLAALGESDLLFALS 60 +LVTRP+ + L+ L G V H P+++ P LP +L L + +S Sbjct: 6 RVLVTRPAGQADSLIGALSDAGFVPLHLPMLQIEPLDPLPGAQRQRLMDLDRYAHVIFVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +A ++ + P+ Y+A+G++TAL L + P+ SE LL +P Sbjct: 66 ANAARLGVERIRDYWPQLPQGQLYWAVGKSTALCLEAEGL-DVRRPERDMSSEGLLAMPG 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + +R LI++G GGR+ + L RGAEV CY+R +D ++ Sbjct: 125 LAELQSQRVLIVKGEGGRKFLEVKLRERGAEVDSLACYRRDYAAHDRQACRDLLGDHDLA 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +++V+SGE L++L SL+ Q L LLV S+R+A+ A LGW ++ A+N Sbjct: 185 LILVSSGEGLERLTSLL-QPEEHTNLAMTTLLVPSQRVAEQALGLGWTHVECAEN 238 >UniRef50_C1ZIN7 Uroporphyrin-III C-methyltransferase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZIN7_PLALI Length = 563 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 86/253 (33%), Gaps = 10/253 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + I + RP GE LG P I S + + + E D + S Sbjct: 284 LRIAIPRPLEQGELTALECEQLGGSPLLMPTISISSIDDWTLVDGIIDRIAEFDWIIFTS 343 Query: 61 QHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V L Q+ IG +TA L + P + EVL + Sbjct: 344 VNGVRCFMQHLWQRGLDGRELAGCRLAVIGASTAAELEKWHLRADFVPS-QFRGEVLAEE 402 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 Q AG+ R N GRE+I + L G + Y+ + A+ + +E Sbjct: 403 LAQQFSAGRAIWF-RANRGREVIPERLQKAGWSMETAVVYRNEDVTSWPADFWEKLSRKE 461 Query: 179 VTMVVVTSGEMLQQLWSLIPQW------YREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 V + ++S M + L+ + ++ R + +S + A E G Sbjct: 462 VDWIALSSPSMARNWKKLLDAYLRESGRNASEFINAARFVSISPVTTQAALEAGLSISAE 521 Query: 233 ADNADNDALLRAL 245 A + + RA+ Sbjct: 522 ASVFTWEGIFRAI 534 >UniRef50_C6N607 Uroporphyrinogen III methylase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N607_9GAMM Length = 251 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 70/245 (28%), Positives = 104/245 (42%), Gaps = 8/245 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L TRP E L + +R V P + L L + D +S Sbjct: 8 LRVLNTRPQGQAELLSNAIRAADGVVLELPTLAIEATPDW---LSTLPDLKKVDQAIFVS 64 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV +QL Q +WP AIG+ A AL + P+ SE LL L Sbjct: 65 ANAVEQCFTQLQQAGFRWPATIRVIAIGQGCAAALKKFNIPIHAMPEIA-DSEHLLTLSS 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + LI +G GGR LI +TL +G + YQR + W+ V Sbjct: 124 LLQPQKQNILIFKGAGGRALIEETLLNKGVNLLALNVYQRVMPKINHQFVKSIWRDDLVD 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++++TS + + L+ L + HWL LV+SERLA++A LG I + D Sbjct: 184 IILLTSEQSMHHLFKLFEKDA-HHWLRQKTCLVISERLAQIASSLGMSTII---RSHPDG 239 Query: 241 LLRAL 245 ++ AL Sbjct: 240 MMNAL 244 >UniRef50_D0I363 Uroporphyrinogen-III synthase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0I363_VIBHO Length = 257 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 94/247 (38%), Positives = 124/247 (50%), Gaps = 4/247 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LV RP+PA ELV L G A PL+ FS G+ LP L + L ++ A+S Sbjct: 1 MTVLVVRPAPACYELVETLNQSGIKALPAPLLSFSEGKDLPVLTNTYRRLPSGSVVVAVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALA-LHTVSGQKILYPQDREISEVLLQLP 119 A+ + Q Q + W Y A+G TA L L P E SE +L L Sbjct: 61 PRAIEYTQQQFRNDNTAWRDDLHYVAVGEKTAQVWLEESGI-NALQPP-TEDSEGMLSLS 118 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 LILRGNGGR L+G TL +RGA+V + E YQR AM+WQA V Sbjct: 119 VFGEPEHLEVLILRGNGGRALLGKTLASRGAKVHYFEAYQRHWTSDSLLSLAMQWQAENV 178 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +VVTSGE L L I + ++ WL C +LV S+R+ A LG+ I+ ++A N Sbjct: 179 DTLVVTSGEQLSLLCQTISESNQQ-WLRECHILVPSKRIYNQAIGLGFNTIRCVNSASNT 237 Query: 240 ALLRALQ 246 AL AL Sbjct: 238 ALFHALN 244 >UniRef50_Q143B4 Uroporphyrinogen III synthase HEM4 n=64 Tax=Burkholderia RepID=Q143B4_BURXL Length = 672 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 70/265 (26%), Positives = 111/265 (41%), Gaps = 24/265 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++TRP+ EL++RL G FPLI+ +P L L++L L+ +S Sbjct: 18 FTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVS 77 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQ----KILYPQDR------- 109 +AV +A ++ D WP +G + AL ++ P Sbjct: 78 PNAVDYAFAR---SDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETAR 134 Query: 110 EISEVLLQLPELQ----NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY 165 SE L + N+ GKR LI+RG+GGRE + + L GAEV Y+R Sbjct: 135 FDSEGLFAAIDTALGATNLEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEP 194 Query: 166 DGAEEAM--RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAK 220 A A ++TS E ++ L L L L+ R+A+ Sbjct: 195 SIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQLKRAALVTPHPRIAQ 254 Query: 221 LARELGWQDIKVADNADNDALLRAL 245 AR LG+ I V+ A ++ ++R L Sbjct: 255 TARALGFDSITVS-GAGDERIVRTL 278 >UniRef50_C7P5B9 Uroporphyrinogen III synthase HEM4 n=1 Tax=Methanocaldococcus fervens AG86 RepID=C7P5B9_METFA Length = 243 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 38/249 (15%), Positives = 87/249 (34%), Gaps = 17/249 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + L+ G FP +E + + L D + S Sbjct: 1 MKVVITRPKERADVFSKLLKKEGFEPIIFPTLELIYNKDIKV------NLDNYDWIVFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + + + R+ + IG TA A G+++ +E LL+ + Sbjct: 55 PSGVIGLYNIIEEAQREEVKNKKIAVIGEKTAKAFKEYFGREVDVMPKEYTAESLLEEIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH---YDGAEEAMRWQAR 177 + + LI R+++ + L A Y+ + + + Sbjct: 115 KTAKSDDKFLIPTTPSTRDVLKNNLNA-----DLLFVYKSVEPENLKENIEKLKENIKDE 169 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++ TSG + + + + E + + ++ + AK+ E G++ + Sbjct: 170 RF-ILTFTSGLTAKNFFKYVDDEFAEI-IKNNYIVAIGPITAKVIEEFGFKP-LIPKIYT 226 Query: 238 NDALLRALQ 246 + +L ++ Sbjct: 227 IEGILEVIK 235 >UniRef50_Q1D8Z7 Uroporphyrinogen-III synthase n=2 Tax=Cystobacterineae RepID=Q1D8Z7_MYXXD Length = 256 Score = 193 bits (491), Expect = 5e-48, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 75/244 (30%), Gaps = 7/244 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP EEL L G PL+E P + LA + + S Sbjct: 9 RVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASP 68 Query: 62 HAVAFAQSQLHQQD-RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V L + + + +G T A + P + LL L + Sbjct: 69 TGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEG-TGAALLNLIK 127 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G L+ GR + D L G VT Y+ A A Sbjct: 128 DALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLA-LLDASPPD 186 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V+ S + + L R++ + A LG VA+ ++ Sbjct: 187 VVLFASPRTAEAFVEEAGRE----RLATARVVAIGPTTASALERLGVPAAAVAERPTPES 242 Query: 241 LLRA 244 L+ A Sbjct: 243 LVDA 246 Score = 72.6 bits (177), Expect = 1e-11, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 41/126 (32%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + + GKR L+ R E + L GAEV + + + T Sbjct: 2 ERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYT 61 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV S + L + + + + ++ V R + A G + A Sbjct: 62 WVVFASPTGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAA 121 Query: 241 LLRALQ 246 LL ++ Sbjct: 122 LLNLIK 127 >UniRef50_A9GHX2 Uroporphyrinogen-III synthase n=3 Tax=cellular organisms RepID=A9GHX2_SORC5 Length = 534 Score = 193 bits (490), Expect = 5e-48, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 91/254 (35%), Gaps = 11/254 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP +R G A P I+ P ++ + + L + S+ Sbjct: 265 RVLVTRPRHQARSTSRLVRLRGGEAVELPTIDIHPPPDPARVTEAVRGLSGYHAVVFTSE 324 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + VA ++ + AIG TA AL + + P++ E+ + Sbjct: 325 NGVACFFKEMDRLGLDARAFGPARLAAIGVGTAAALAARGVRADIVPREFRGEELAEAIL 384 Query: 120 ELQNIAGK-------RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD-GAEEA 171 +AG+ R L+ R RE++ + L A G EV Y+ E Sbjct: 385 ADPALAGRRAASPRVRVLLARALVAREVLPERLRAAGCEVDVVPVYETRPASAGRREELL 444 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 A + +V++TS + L L+ + L L + A + G + Sbjct: 445 RALSAGAIDVVLLTSSSTVDSLCDLLGE-GAAARLERVLLASIGPITTATAEKRGLRIGV 503 Query: 232 VADNADNDALLRAL 245 A+ + LL AL Sbjct: 504 TAEVSTTAGLLDAL 517 Score = 53.7 bits (128), Expect = 5e-06, Method: Composition-based stats. Identities = 26/210 (12%), Positives = 52/210 (24%), Gaps = 25/210 (11%) Query: 37 GQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALH 96 + A + +D S+ + ++ + + P +G T Sbjct: 198 RRDPATPAAAIQWGTRADQRVVSSR--LDDLHRRVKEAGIESPA---VIVVGAVT----- 247 Query: 97 TVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCE 156 + L+ + + + GKR L+ R + RG E Sbjct: 248 --GLRDT------------LRWFDRKPLFGKRVLVTRPRHQARSTSRLVRLRGGEAVELP 293 Query: 157 CYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVS 215 VV TS + + + + + RL + Sbjct: 294 TIDIHPPPDPARVTEAVRGLSGYHAVVFTSENGVACFFKEMDRLGLDARAFGPARLAAIG 353 Query: 216 ERLAKLARELGWQDIKVADNADNDALLRAL 245 A G + V + L A+ Sbjct: 354 VGTAAALAARGVRADIVPREFRGEELAEAI 383 >UniRef50_B5YJZ5 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJZ5_THEYD Length = 509 Score = 192 bits (489), Expect = 8e-48, Method: Composition-based stats. Identities = 48/252 (19%), Positives = 92/252 (36%), Gaps = 13/252 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+TR E L +G + FP I F+P + +L + + E + S Sbjct: 256 RVLITR---QLTEDYLLLEDMGAELFVFPTIAFAPPEDFKELDRAIEKIKEYKFIVFPSP 312 Query: 62 HAVAFAQSQLHQQDRKWPRLPDY--FAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV F + R L AIGR TA +L + P + SE L+ + Sbjct: 313 RAVNFFFERFLSLGRDMRDLKGVLLCAIGRETAKSLRNFGINADIIPDE-YSSEALITMF 371 Query: 120 ELQNIA------GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR 173 + + + + L R + + + + G +V Y+ G A Sbjct: 372 KEKILNFQPSAFSLKILYPRSDLALKGFVEEMEKIGIQVDAPVTYRTIKPTEHGKRLARF 431 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + ++T+ TS L ++ + L + V+ + AK E G++ + Sbjct: 432 LREGKITIATFTSPSSFNNLIDILKDDAL-NMLKEVAIAVIGKTTAKAVEEAGYRVSIIP 490 Query: 234 DNADNDALLRAL 245 + + ++ A+ Sbjct: 491 EKSTIKHMVEAI 502 >UniRef50_Q6SHZ5 Uroporphyrinogen-III synthase n=1 Tax=uncultured marine bacterium 106 RepID=Q6SHZ5_9BACT Length = 275 Score = 192 bits (489), Expect = 8e-48, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 96/248 (38%), Gaps = 4/248 (1%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + LVTR L L + G + + P + + + + + D S Sbjct: 17 LRFLVTRLDSTESSLSGMLESQGASVLTAQMTQIIPTESWESFDETVQQISKIDWAVFTS 76 Query: 61 QHAVAFAQSQLHQQ---DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 ++ V S+L+ ++ +G+ TA L L P + SE L+ Sbjct: 77 RNGVTHCLSRLNDLEVSAQQLFSSIKTACVGQATASVLTDNGITPELVP-EHFQSEGLIY 135 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + ++ KR +++ R+++ D+L GA++ Y+ + D + + Sbjct: 136 AFKQHDLFEKRCWLIQAESPRKILQDSLQKMGAQIILTPVYRNVPVAGDYTFLLTELEQQ 195 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++ ++ S +Q ++P + E ++ + + AK AR+ GW + D Sbjct: 196 KLDWILFASPSAVQNFHQILPSGFWESLAAEPKIACLGKITAKAARDFGWSVQVAPNIQD 255 Query: 238 NDALLRAL 245 L+++L Sbjct: 256 FQHLVQSL 263 Score = 54.1 bits (129), Expect = 4e-06, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 46/129 (35%), Gaps = 2/129 (1%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E +AG R L+ R + + L ++GA V + Q + + Q ++ Sbjct: 10 EKSPLAGLRFLVTRLDSTESSLSGMLESQGASVLTAQMTQIIPTESWESFDETVQQISKI 69 Query: 180 TMVVVTSGEMLQQLWSLIPQWY--REHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 V TS + S + + + V + A + + G V ++ Sbjct: 70 DWAVFTSRNGVTHCLSRLNDLEVSAQQLFSSIKTACVGQATASVLTDNGITPELVPEHFQ 129 Query: 238 NDALLRALQ 246 ++ L+ A + Sbjct: 130 SEGLIYAFK 138 >UniRef50_Q3B017 Uroporphyrinogen-III synthase n=19 Tax=Cyanobacteria RepID=Q3B017_SYNS9 Length = 272 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 89/250 (35%), Gaps = 9/250 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TR + E L G P + P L D LA L L S Sbjct: 16 TVVITRAAEQQGEAKELLEAKGANVLDLPALVIVPPDHWGPLDDALADLDNFHWLVFSSA 75 Query: 62 HAVAFAQSQLHQQDR---KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V + +L +Q R + PR A+GR TA L + P ++E L+ Sbjct: 76 NGVLAVEQRLQRQQRNLCRLPRGLKIAAVGRKTARLLEELGAPADFVPP-SFVAESLIDH 134 Query: 119 PELQNIAGKRALILR-GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + G L+ R GGR ++ D G V Y + A Sbjct: 135 FPVSGW-GLTMLLPRVQQGGRTVLADAFGEAGVRVVEVAAYDSRCPEHMAEPAATALADG 193 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQDIKVAD 234 V + TSG+ L+ + + W L ++ + + ++ RE + AD Sbjct: 194 AVDAIAFTSGKTATHTAQLMEKRFGSEWKQHLNGVAVVSIGPQTSRSCREHFGRVDAEAD 253 Query: 235 NADNDALLRA 244 D + L+ A Sbjct: 254 PHDLEGLVEA 263 Score = 60.2 bits (145), Expect = 7e-08, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 42/131 (32%), Gaps = 2/131 (1%) Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 L Q + + +I R + + L A+GA V + G + Sbjct: 3 LPASRSDQPLQHRTVVITRAAEQQGEAKELLEAKGANVLDLPALVIVPPDHWGPLDDALA 62 Query: 175 QAREVTMVVVTSGEMLQQLWSLI--PQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 +V +S + + + Q ++ V + A+L ELG V Sbjct: 63 DLDNFHWLVFSSANGVLAVEQRLQRQQRNLCRLPRGLKIAAVGRKTARLLEELGAPADFV 122 Query: 233 ADNADNDALLR 243 + ++L+ Sbjct: 123 PPSFVAESLID 133 >UniRef50_Q8EPM9 Uroporphyrinogen-III synthase n=1 Tax=Oceanobacillus iheyensis RepID=Q8EPM9_OCEIH Length = 252 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 80/243 (32%), Gaps = 10/243 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+TR E ++ G PL+ + L + + + S + Sbjct: 10 VLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNP--IWLHLKKYEWILFTSSN 67 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V LHQ D ++P +G T LAL + P +E + + Sbjct: 68 GVHGFFHFLHQLDIEFPSDIKVGIVGTKTKLALDEYELKPDFIPSI-FDAETMAKEFIES 126 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + LI+RGN R +I + T E Y+ + E + V V Sbjct: 127 YDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEVYETTYRYEAKRELEDTIKN--VDFV 184 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 +TS + L L+ C + + A +L ++ + DA++ Sbjct: 185 TLTSPSTVTALMKLVKDIP-----FSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMI 239 Query: 243 RAL 245 + Sbjct: 240 EVM 242 >UniRef50_C4LDV5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Tolumonas auensis DSM 9187 RepID=C4LDV5_TOLAT Length = 241 Score = 191 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 95/246 (38%), Positives = 133/246 (54%), Gaps = 6/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+ L+ RP PA EL + LR G PL+ + PG +L L L ++++ A+S Sbjct: 1 MTPLILRPQPAAGELAAYLRRDGHTPVVCPLLTYQPGDELALLPAL---LKQAEITLAVS 57 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV FA L QQ WP Y A+G TA + ++ P D SE LL P Sbjct: 58 AAAVQFASRHLQQQKILWPPALTYLAVGPATAAEWQQQGLR-VISPADAR-SEGLLAQPA 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ++ GK+ +ILRGNGGREL+ +TL RGA+V+ ECY+R + DGA WQA V Sbjct: 116 LQSVNGKKIVILRGNGGRELLTETLRHRGAQVSCVECYRRHYLQTDGARLLQEWQAAAVD 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V++TS E+ +QL L+P +WL R V SER+A+ R G++ I + A + A Sbjct: 176 SVIITSSELFRQLLILLPDTAG-NWLSALRWFVASERIAEEIRHSGFKQITIMSGAQHQA 234 Query: 241 LLRALQ 246 + AL Sbjct: 235 VAAALS 240 >UniRef50_C5BLH7 Uroporphyrinogen-III synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BLH7_TERTT Length = 266 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 79/249 (31%), Positives = 115/249 (46%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ---LADQLAALGESDLLFA 58 IL +RP S+L+ G PL+ + Q+ Q + + + D + Sbjct: 8 RILASRPLAQNSSWSSKLQAAGYRVLALPLLAIAQVQEPAQQQSIKNCILDFDHYDAVIF 67 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK--ILYPQDREISEVLL 116 +SQ+AV L Q + P+ Y+A+G TA + G + + +E LL Sbjct: 68 VSQNAVEATWQWLDQYWPQLPQGITYYAVGIKTAAQVQHFLGSEATVHAALTAMNTEELL 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LP LQ +A +R LI RG GGR +GD L RGA VT+CE YQR + Sbjct: 128 ALPGLQQVAHQRILICRGLGGRPRLGDELENRGAAVTYCELYQRTLPAEAVTQFTDANLN 187 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 ++ V SGE LQ L + + L L+V ER+A LA E G+Q I++A NA Sbjct: 188 PAQDVLCVFSGETLQNLLYVATTAGAD--LSAFALVVPGERVAALAAEQGFQQIQIARNA 245 Query: 237 DNDALLRAL 245 A+L A+ Sbjct: 246 GEAAMLAAI 254 Score = 39.8 bits (92), Expect = 0.073, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 34/128 (26%), Gaps = 3/128 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPL-IEFSPGQQLPQLADQLAALGESDLLFALS 60 IL+ R L L G + L P + + Q D + D+L S Sbjct: 139 RILICRGLGGRPRLGDELENRGAAVTYCELYQRTLPAEAVTQFTDANLNPAQ-DVLCVFS 197 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + G A Q+I ++ + +L + E Sbjct: 198 GETLQNLLYVATTAGADLSAFALV-VPGERVAALAAEQGFQQIQIARNAGEAAMLAAIDE 256 Query: 121 LQNIAGKR 128 + K Sbjct: 257 IIATLDKT 264 >UniRef50_Q59683 Uroporphyrinogen-III synthase n=2 Tax=Proteus RepID=HEM4_PROMI Length = 199 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 94/195 (48%), Positives = 121/195 (62%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 MSIL+TRPSPAGE+L RL G+ A+H PLIE + G++L L ++L L D LF LS Sbjct: 1 MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++AV +A QL+Q + WP Y+ IG++TA ++ I YP+ E SE LL L Sbjct: 61 KNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I KR L+LRGNGGREL+ TL RGA V CECYQR I Y E A++W+ +V Sbjct: 121 LQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVE 180 Query: 181 MVVVTSGEMLQQLWS 195 + EMLQQL S Sbjct: 181 YLCGHQCEMLQQLLS 195 >UniRef50_UPI0001972E7B uroporphyrin-III C-methyltransferase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972E7B Length = 542 Score = 190 bits (483), Expect = 4e-47, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 81/267 (30%), Gaps = 26/267 (9%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP + RLR G P E + L L L + S Sbjct: 271 KILVTRPKRRSAGMAGRLREAGAEVVELPAAEPRLLEDTSFLDRTLERLADFKWAVFTSP 330 Query: 62 HAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREI-------S 112 V L ++D + + IG TA AL P++ + Sbjct: 331 SGVELFFEYLRREKKDIRLLMGLKFAVIGAGTAKALCRYGFYADYMPENFYAKELGRGLA 390 Query: 113 EVLLQLPELQNIAGK------------RALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 E +L + + G+ + L+LR + + L Y+ Sbjct: 391 ETILHEMKEEEKRGENGRGGAGCGKPVKVLLLRAQKASPALCEELARAEIPFEDAVLYRT 450 Query: 161 CAIHYD--GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERL 218 + + + V TS ++ L+ + L + + E Sbjct: 451 EFPAPSMQAERVKILLEKKAFDYVTFTSESTVKGFLELLSPT--DEELCGFTAVCIGEMT 508 Query: 219 AKLARELGWQDIKVADNADNDALLRAL 245 K ARE G + + ++ D++ + Sbjct: 509 EKAAREAGMRTV-TSEVPSMDSMAECM 534 Score = 68.3 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 49/134 (36%), Gaps = 2/134 (1%) Query: 103 ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA 162 I+ + +SE L Q E + + G + L+ R + L GAEV + Sbjct: 247 IVVGEVCSLSESL-QWMEEKPLFGAKILVTRPKRRSAGMAGRLREAGAEVVELPAAEPRL 305 Query: 163 IHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKL 221 + + + + V TS ++ + + + ++ L+ + V+ AK Sbjct: 306 LEDTSFLDRTLERLADFKWAVFTSPSGVELFFEYLRREKKDIRLLMGLKFAVIGAGTAKA 365 Query: 222 ARELGWQDIKVADN 235 G+ + +N Sbjct: 366 LCRYGFYADYMPEN 379 >UniRef50_B1ZV86 Uroporphyrinogen III synthase HEM4 n=3 Tax=Verrucomicrobia RepID=B1ZV86_OPITP Length = 270 Score = 190 bits (483), Expect = 4e-47, Method: Composition-based stats. Identities = 50/247 (20%), Positives = 92/247 (37%), Gaps = 4/247 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTR EL ++L LG PLI S LAD L LG D + S Sbjct: 14 RIIVTRAREQASELSAKLTALGAEVLELPLIRVSKHISKEALADVLLELGSYDWIVFTSA 73 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL-QL 118 + V + + + D + L + +G TA + + + P+ E L L Sbjct: 74 NGVRYFFEEFLRIFDDIRSLGLLRFACVGDATAKGIRELHLKVECQPKVA-TGEALADAL 132 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 E ++ + +++ GN R+++ L A V + YQ + A ++ + Sbjct: 133 IETGSLDNAKVVVITGNLNRDVLVTKLEGAHAIVDQLQVYQTERVDLTDNPAAAEFRTQG 192 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V+ S + + + + ++ + G + VA + Sbjct: 193 ADAVLFASSSAVDSFAAQQAALTLQKGAKPPLFGSIGPLTSESLTKAGLEIGFVAKEPNL 252 Query: 239 DALLRAL 245 D+L++AL Sbjct: 253 DSLVQAL 259 Score = 69.1 bits (168), Expect = 1e-10, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 46/124 (37%), Gaps = 3/124 (2%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM-RWQAREVTMV 182 + G+R ++ R + LTA GAEV + + H A + + Sbjct: 10 LHGRRIIVTRAREQASELSAKLTALGAEVLELPLIR-VSKHISKEALADVLLELGSYDWI 68 Query: 183 VVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS ++ + + + + L R V + AK REL + A +AL Sbjct: 69 VFTSANGVRYFFEEFLRIFDDIRSLGLLRFACVGDATAKGIRELHLKVECQPKVATGEAL 128 Query: 242 LRAL 245 AL Sbjct: 129 ADAL 132 Score = 39.4 bits (91), Expect = 0.098, Method: Composition-based stats. Identities = 18/127 (14%), Positives = 41/127 (32%), Gaps = 2/127 (1%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++T + LV++L + + + A +D + S Sbjct: 144 VVITGNLNR-DVLVTKLEGAHAIVDQLQVYQTERVDLTDNPAAAEFRTQGADAVLFASSS 202 Query: 63 AVAFAQSQLHQQDRKWPRLPDYF-AIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV +Q + P F +IG T+ +L + ++ + ++ L + Sbjct: 203 AVDSFAAQQAALTLQKGAKPPLFGSIGPLTSESLTKAGLEIGFVAKEPNLDSLVQALVKK 262 Query: 122 QNIAGKR 128 R Sbjct: 263 LGARESR 269 >UniRef50_B5JT00 Putative uncharacterized protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JT00_9GAMM Length = 618 Score = 190 bits (482), Expect = 4e-47, Method: Composition-based stats. Identities = 67/246 (27%), Positives = 107/246 (43%), Gaps = 9/246 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TR + + L++ + G + ++ P + AAL + +S Sbjct: 8 LRVLITRTAKQAKPLLTLIEAEGGMGTPAGVLSIEADYGDPSVTAAKAALDQYHRFIFVS 67 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L P +GR T L P+ SE LL LP Sbjct: 68 ANAVEHGLAALGS----LPDEARLACVGRKTRQTLEQAGYSVADCPESDFNSEALLALPS 123 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQN+ G+R LI+RG+GGR+LI DTL RGA+V ECY R D ++ Sbjct: 124 LQNVDGERILIVRGHGGRQLIRDTLQQRGAQVDSVECYHRQLSDGDFRPLQDAIESGAFD 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI-KVADNADND 239 ++ + +L+ Q L L+ VS + ARELG+ I +A +A ++ Sbjct: 184 VIC----PSSSESLALLSQACPSKSLKSLPLIAVSATMQDKARELGFTQIAAMAKDATDE 239 Query: 240 ALLRAL 245 ++ AL Sbjct: 240 SIFDAL 245 >UniRef50_Q2SQ71 Uroporphyrinogen-III synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SQ71_HAHCH Length = 260 Score = 190 bits (482), Expect = 5e-47, Method: Composition-based stats. Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 8/250 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP + L + L P I P + + D + L + +S Sbjct: 12 LRVLLTRPQGENDSLRALLEQNSAEVRVLPAIAIEPLPETQAIKDCILDLDRYTHVICVS 71 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +HA + + P+ +FAIG ++A L + + P+ SE LL+ P Sbjct: 72 KHASRLLLELIDAYWPQAPQGVRWFAIGESSAAPLRSYGLT-VNTPEQGCASEQLLEHPG 130 Query: 121 LQ----NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 LQ + R LI++G GGREL+ +T+ RGA V E Y+R + YD E + Sbjct: 131 LQARNEDEPPMRVLIVKGCGGRELLTETMQERGAHVATLELYERKTLEYDPNELNEALKQ 190 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +VV SGE L L L ++ S R+A LA+E + K+A Sbjct: 191 WRPEVVVTLSGETLLHLCQLGQNIGYAWG--DTLFVIPSARVATLAQENRL-NYKIAPEL 247 Query: 237 DNDALLRALQ 246 ++ALL L+ Sbjct: 248 SDEALLALLK 257 Score = 53.3 bits (127), Expect = 8e-06, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 35/108 (32%), Gaps = 1/108 (0%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q ++G R L+ R G + + L AEV + A + T Sbjct: 7 QELSGLRVLLTRPQGENDSLRALLEQNSAEVRVLPAIAIEPLPETQAIKDCILDLDRYTH 66 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD 229 V+ S + L LI ++ + R + E A R G Sbjct: 67 VICVSKHASRLLLELIDAYWPQA-PQGVRWFAIGESSAAPLRSYGLTV 113 >UniRef50_Q5X1F1 Uroporphyrinogen-III synthetase n=4 Tax=Legionella pneumophila RepID=Q5X1F1_LEGPA Length = 250 Score = 189 bits (481), Expect = 6e-47, Method: Composition-based stats. Identities = 61/245 (24%), Positives = 111/245 (45%), Gaps = 7/245 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + IL TRP + L ++ G + P +E + + L L + +S Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENN--WINNLPDLTSVNQAIFVS 65 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + +L ++ W AIG+ T+ L+ + Q P+ SE LL L Sbjct: 66 ANAVRYFMMELASKNINWLNSIRVAAIGKGTSRVLNEFNIQVSDVPELP-DSEHLLTLNS 124 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I + L+++G GGR+LI + L +GA++ Y+R D W+ Sbjct: 125 LQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDQEFLNSLWRDDLAD 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++++TS + + L+ + + WL + LV+S+RLAK+A G + I ++ + Sbjct: 185 IILLTSEQSIHNLFKMFSIEGQM-WLQNKPCLVISDRLAKVASLFGIKKILISH---PER 240 Query: 241 LLRAL 245 ++ L Sbjct: 241 MIGTL 245 >UniRef50_Q5WEP6 Uroporphyrinogen III cosynthase n=1 Tax=Bacillus clausii KSM-K16 RepID=Q5WEP6_BACSK Length = 252 Score = 189 bits (481), Expect = 6e-47, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 82/245 (33%), Gaps = 12/245 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 IL+TR E + L LG + PLI+ P L + A L + + S + Sbjct: 9 ILITRDERQNERWAAELAVLGAIPHSLPLIQCVTRNLTPALRETFAHLHQFAWVVFTSAN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 V Q P + A+G TA L P + E L + Sbjct: 69 GVRAFFDLYKGQ----PFMAKVAAVGPKTAQLLEEQGLHCDFIPSE-YTGEALAKELVPL 123 Query: 123 NIAGKRALILRGNGGRELIGDTLTA--RGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L+++G + + D L++ R A VT Y E+A R Q + Sbjct: 124 LAPHSDVLVVKGQLAKRTVCDILSSSDRQATVTEMIVYDTLCPAG-AEEQAKRLQQKTFD 182 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V +TS ++ P + + + A+ A++ G + A Sbjct: 183 YVTLTSTSAAVHYANVAPAAG----IRAKTIACIGPVTARAAKQCGLSPLVTASEYTVKG 238 Query: 241 LLRAL 245 L+ + Sbjct: 239 LIDTI 243 Score = 64.1 bits (155), Expect = 4e-09, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 39/125 (31%), Gaps = 5/125 (4%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ + GK LI R E L GA Q + A + Sbjct: 1 MKPLKGKHILITRDERQNERWAAELAVLGAIPHSLPLIQCVTRNLTPALRETFAHLHQFA 60 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VV TS ++ + L ++ V + A+L E G + +A Sbjct: 61 WVVFTSANGVRAFFDLYKGQPFMA-----KVAAVGPKTAQLLEEQGLHCDFIPSEYTGEA 115 Query: 241 LLRAL 245 L + L Sbjct: 116 LAKEL 120 >UniRef50_A9KP84 Uroporphyrin-III C-methyltransferase n=4 Tax=Clostridiales RepID=A9KP84_CLOPH Length = 502 Score = 188 bits (479), Expect = 1e-46, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 80/248 (32%), Gaps = 9/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTRP L +L++ G P I +P + L + L L + L S Sbjct: 255 KIVVTRPKELVSTLSEKLKSKGAEVLEIPTIRIAPLKNNIVLKNTLLQLDQFQWLVFTSP 314 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V + + ++ +G T + L P++ + L + Sbjct: 315 SGVDVFFNAMKEEKIDIRKLANLKVAVVGEGTKKKVEDRGILVDLIPENYY-GKSLGKSI 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARG-AEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + G R LI R + G E I + + EV Y D ++ Sbjct: 374 RMSCCDGDRILIPRASIGNEEIMEEIKKNPLLEVMDIPIYDTVYSTPDIINLKDEFERGN 433 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + V TS + + + E+ A++ + ++ A Sbjct: 434 IDFAVFTSKSTVTGFVKATKDLDYHL----VNAVCIGEQTRDEAQKNNMKT-WMSKKATI 488 Query: 239 DALLRALQ 246 D+L+ ++ Sbjct: 489 DSLVETIE 496 Score = 71.0 bits (173), Expect = 3e-11, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 54/128 (42%), Gaps = 1/128 (0%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E + ++GK+ ++ R + + L ++GAEV + + + + Q + Sbjct: 247 EKRPLSGKKIVVTRPKELVSTLSEKLKSKGAEVLEIPTIRIAPLKNNIVLKNTLLQLDQF 306 Query: 180 TMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +V TS + ++ + + + L + ++ VV E K + G + +N Sbjct: 307 QWLVFTSPSGVDVFFNAMKEEKIDIRKLANLKVAVVGEGTKKKVEDRGILVDLIPENYYG 366 Query: 239 DALLRALQ 246 +L ++++ Sbjct: 367 KSLGKSIR 374 >UniRef50_Q58401 Putative uroporphyrinogen-III synthase n=8 Tax=Methanococcales RepID=HEM4_METJA Length = 240 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 88/248 (35%), Gaps = 15/248 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + S L+ G FP +E + L L D + S Sbjct: 1 MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDV------NLDSYDWIAFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + L + +R+ + IG TA G+ + +E LL+ + Sbjct: 55 PSGVIGLYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR--WQARE 178 + ++ LI R+++ + L A Y+ + A++ Sbjct: 115 KVSKEEEKFLIPTTPSTRDVLKNNLNA-----DLLFVYKSAEPENLKEDIKKLKELIAKD 169 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ TSG + + + + E + ++ + AK+ + G++ + Sbjct: 170 KFILTFTSGLTAKNFFKYVDDEFAEI-IKDNYIVAIGPITAKVIEKFGFKP-LIPKVYTI 227 Query: 239 DALLRALQ 246 + +L ++ Sbjct: 228 EGMLEVIR 235 >UniRef50_Q2NF31 HemD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NF31_METST Length = 259 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 78/253 (30%), Gaps = 16/253 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TRP + L + G P +E + +L + + D + S Sbjct: 10 NVVITRPIERSQTLSDMILKKGGKPIIVPTLELQ-LVESKELVYIIENIETFDWIVFTSP 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V L + D IG T L + L P+D +E LL+ + Sbjct: 69 AGVKSFFK-LCKLDIIPS---KIAVIGVKTEEELLKYGFKPDLIPKD-FTAEGLLESFKS 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMRWQAREV 179 N+ K + R RE++ L GA V E Y H E V Sbjct: 124 INLKNKNVALPRTLSAREVLPKGLEDYGASVLIAEAYTSGIPHDTTKIIELCNDIIDGLV 183 Query: 180 TMVVVTSGEMLQQLWSLIPQWYRE-------HWLLHCRLLVVSERLAKLARELGWQDIKV 232 ++ TS ++ L + + + AK E G I Sbjct: 184 DIITFTSPLTVKNLMEVYKNSQPSRLDELILALKSRVVVASIGPITAKSLSEYGICTI-E 242 Query: 233 ADNADNDALLRAL 245 ++ A+ Sbjct: 243 PSRYTVKDMVEAI 255 Score = 64.5 bits (156), Expect = 3e-09, Method: Composition-based stats. Identities = 15/126 (11%), Positives = 41/126 (32%), Gaps = 8/126 (6%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVT 180 N K +I R + + D + +G + + + E + Sbjct: 4 NNFNNKNVVITRPIERSQTLSDMILKKGGKPIIVPTLELQLVE--SKELVYIIENIETFD 61 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS ++ + L ++ V+ + + + G++ + + + Sbjct: 62 WIVFTSPAGVKSFFKLCKLDIIPS-----KIAVIGVKTEEELLKYGFKPDLIPKDFTAEG 116 Query: 241 LLRALQ 246 LL + + Sbjct: 117 LLESFK 122 >UniRef50_Q8D2W1 HemD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W1_WIGBR Length = 245 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 89/245 (36%), Positives = 149/245 (60%), Gaps = 1/245 (0%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+IL+TRP P G+ L++ +R G+ AW+ PLI F+ G L L + L E D++ +LS Sbjct: 1 MTILITRPYPHGQHLINMIRKNGKEAWYLPLIYFTSGIGLLSLTNFFKKLQEKDIICSLS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A +A Q+ + WP+ +Y+AIG+T+A L S K++YP+ E SE LL L Sbjct: 61 PRATKYANYQILLEKCNWPKKINYYAIGKTSAFYLSKYSKCKVIYPKLTENSENLLDLIS 120 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +++ K+ LIL+GN GR+ + + L GA + ECY+R I Y+ + + ++ Sbjct: 121 KEDVK-KKILILKGNNGRKFLENKLKLYGAYIINVECYKRNFIKYNKYDYLKKIINLKIN 179 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +VVTS E+L QL + IP Y +L++ +L+VVS+R++ +A LGW++I V+ ++ N Sbjct: 180 TLVVTSSEILHQLHNNIPLNYINFFLINFKLVVVSKRISDIADNLGWKNIIVSKSSKNKD 239 Query: 241 LLRAL 245 ++++L Sbjct: 240 IIQSL 244 >UniRef50_UPI000050FC32 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050FC32 Length = 530 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 77/250 (30%), Gaps = 12/250 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFALS 60 +L+ R G L LG V P I P + Q+ + L G + + S Sbjct: 256 VLIPRTKEQGTSTAEALGELGAVGTVVPTIAVQPPRTPTQMEKAIRGLVDGSYEWVGFTS 315 Query: 61 QHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV + A+G TA +L L P + L Sbjct: 316 VNAVRAVRMWFEDFGLDSRSLSGVKVAAVGGRTAASLIDWGITPDLVPDGEHSARGLAAA 375 Query: 119 P---ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L+ R + E++ L +G + Y+ A + Sbjct: 376 WPDYVDDIDPMNTVLLPRADIATEVLVAGLLEKGWDPDDVTAYRTVRASPPPAPIREAIK 435 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 A + + TS ++ L + + + + A A E G + +A+ Sbjct: 436 AGDFDAFLFTSSSTVRNLVGIAGKPASTS-----VICCIGPATANTAAEHGLRVDVLAEE 490 Query: 236 ADNDALLRAL 245 A+ +L+ L Sbjct: 491 ANLTSLIDGL 500 Score = 57.6 bits (138), Expect = 3e-07, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 40/154 (25%), Gaps = 4/154 (2%) Query: 95 LHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTF 154 + + ++ S L E + + G + LI R + L GA T Sbjct: 222 AQSGGDRMVVIMGQGVESRSELSWFETKPLFGWQVLIPRTKEQGTSTAEALGELGAVGTV 281 Query: 155 CECYQRCAIHYDG--AEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW-LLHCRL 211 + V TS ++ + + + L ++ Sbjct: 282 VPTIAVQPPRTPTQMEKAIRGLVDGSYEWVGFTSVNAVRAVRMWFEDFGLDSRSLSGVKV 341 Query: 212 LVVSERLAKLARELGWQDIKVAD-NADNDALLRA 244 V R A + G V D L A Sbjct: 342 AAVGGRTAASLIDWGITPDLVPDGEHSARGLAAA 375 Score = 54.5 bits (130), Expect = 4e-06, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 29/109 (26%), Gaps = 4/109 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+ R A E LV+ L G P + G+ D S Sbjct: 388 TVLLPRADIATEVLVAGLLEKGWDPDDVTAYRTVRASPPPAPIREAIKAGDFDAFLFTSS 447 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDRE 110 V L K IG TA + + ++ Sbjct: 448 STVR----NLVGIAGKPASTSVICCIGPATANTAAEHGLRVDVLAEEAN 492 >UniRef50_UPI00016C4E5B uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4E5B Length = 513 Score = 188 bits (477), Expect = 2e-46, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 92/249 (36%), Gaps = 7/249 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LVTRP+ +V +L LG V P +E + L L GE D L Sbjct: 260 RVLVTRPAHQAGGMVRKLEHLGAVVSRLPAVEIRDVDNFASVDRALGQLRHGEWDWLVFT 319 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S + V +L R AIG TA +L + + P SE L Sbjct: 320 SANGVHALLRRLDTIGRDLRDLGGVKLAAIGPKTAESLREYRLRADVVPDTTFSSEGLAG 379 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + +AG+R L+ R N GREL+ L A V Y + + + Sbjct: 380 ALKPH-VAGQRVLLARANRGRELLRTELAKV-ATVEQVTVYDQVDVTAPEGAVLDALRRG 437 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLL-HCRLLVVSERLAKLARELGWQDIKVADNA 236 E+ V + S + + + + + +L+V+S K R LG+ A Sbjct: 438 EIRFVTLPSSSIAKGVLAAFDETINGRVERGEIKLIVISPETGKAVRALGYPVAAEATTF 497 Query: 237 DNDALLRAL 245 D L+ A+ Sbjct: 498 TEDGLIEAV 506 Score = 64.5 bits (156), Expect = 3e-09, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 47/133 (35%), Gaps = 4/133 (3%) Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH--YDGAEEAMRWQ 175 E + + G+R L+ R + L GA V+ + + + + Sbjct: 250 WFEGRPLFGQRVLVTRPAHQAGGMVRKLEHLGAVVSRLPAVEIRDVDNFASVDRALGQLR 309 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 E +V TS + L + R+ L +L + + A+ RE + V D Sbjct: 310 HGEWDWLVFTSANGVHALLRRLDTIGRDLRDLGGVKLAAIGPKTAESLREYRLRADVVPD 369 Query: 235 -NADNDALLRALQ 246 ++ L AL+ Sbjct: 370 TTFSSEGLAGALK 382 >UniRef50_C6HUG3 Uroporphyrin-III C-methyltransferase / synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG3_9BACT Length = 539 Score = 188 bits (477), Expect = 2e-46, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 81/248 (32%), Gaps = 8/248 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR +EL L LG FP I SP + + L + + LS Sbjct: 265 RILLTRERSRSKELSETLEALGATVITFPTIHVSPSFSEKSMHT-IEHLKDFAWIVFLSP 323 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + L + ++ F++G T+ AL+ + L P + V+ Sbjct: 324 NGVQYFLEGLGKSNKDLRSLAGLRIFSMGPATSTALNEAGLRPDLAPAESHGEGVIDAFR 383 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG---AEEAMRWQA 176 L + L++RG+ G I L G V Y+ Sbjct: 384 NLPEPHSGKVLLVRGDRGTGAIPRGLEELGYGVETISVYENTLPDVPSYRMERLRTILDE 443 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + + + S ++ SL P + L + + Q + +A N Sbjct: 444 GAIDLAIFYSPSAIRGFISLFPDH--AEAISRIPSLAIGPTTREELLRSAIQTLVMAKNP 501 Query: 237 DNDALLRA 244 +++ Sbjct: 502 TTPSVVET 509 Score = 72.6 bits (177), Expect = 1e-11, Method: Composition-based stats. Identities = 20/155 (12%), Positives = 46/155 (29%), Gaps = 4/155 (2%) Query: 93 LALHTVSGQKILYPQDREISEVLLQLPELQNIA--GKRALILRGNGGRELIGDTLTARGA 150 L + + + + GKR L+ R + + +TL A GA Sbjct: 228 AFLKEHGIAPPAILTIGGVVSLRKDVSWSHRLPLLGKRILLTRERSRSKELSETLEALGA 287 Query: 151 EVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHC 209 V + + ++ +V S +Q + + ++ L Sbjct: 288 TVITFPTIH-VSPSFSEKSMHTIEHLKDFAWIVFLSPNGVQYFLEGLGKSNKDLRSLAGL 346 Query: 210 RLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 R+ + + E G + + + ++ A Sbjct: 347 RIFSMGPATSTALNEAGLRPDLAPAESHGEGVIDA 381 >UniRef50_Q21EF8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Saccharophagus degradans 2-40 RepID=Q21EF8_SACD2 Length = 290 Score = 187 bits (475), Expect = 3e-46, Method: Composition-based stats. Identities = 75/271 (27%), Positives = 117/271 (43%), Gaps = 25/271 (9%) Query: 1 MSILVTRPSPAGEELVSRLR----TLGQVAWHFPLIEFSPG---QQLPQLADQLAALGES 53 + I+ +RP E R+ A PL+E P + QL Q L + Sbjct: 8 IRIIASRPVAQNSEWCKRIEMFNSEAVWRALPIPLLEIIPVTGEAEKRQLQTQALGLDDY 67 Query: 54 DLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHT-------VSGQKILYP 106 + +SQ+AV + L + P+ + +G T A+ Q +L Sbjct: 68 QKILFVSQNAVEHFFTCLEDYWPQLPKQLCFIGVGEKTKQAILQQLDRWGCAGDQIVLGG 127 Query: 107 QDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYD 166 D SE LL +PELQ + ++ LI RG GGR ++G+ L ARGA + +CE YQR Sbjct: 128 VDAMNSEALLAMPELQQVDAEKILICRGVGGRPMLGEILVARGARIEYCELYQRALPKQA 187 Query: 167 GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCR-----------LLVVS 215 A A + V SGE L L +++ + ++V Sbjct: 188 VAVLAEADLNSTTDICPVFSGETLTNLVAVLAKHSNPRASEKPPFRLPAQWRALIVVVPG 247 Query: 216 ERLAKLARELGWQDIKVADNADNDALLRALQ 246 ER+A+ A+ +G++ I VA NA A+L+A+Q Sbjct: 248 ERVAQHAKAVGFKRIAVAKNATEPAMLKAIQ 278 >UniRef50_D1YA62 Uroporphyrinogen-III synthase n=2 Tax=Propionibacterium acnes RepID=D1YA62_PROAC Length = 571 Score = 186 bits (474), Expect = 4e-46, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 83/243 (34%), Gaps = 12/243 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +IL+ R L SRL++ G + P I P + Q+ + L G + + Sbjct: 293 NILIPRTRDHSATLPSRLQSYGAHSLDVPTISMEPPRTPQQMDKAIRGLVEGRYEWVVFT 352 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV +L Q AI +T AL + P + + L Sbjct: 353 SANAVRAVSEKLEQIGLDARAYSGLRIAAIFDSTINALAEWGVRPDFVPSGEQSTRALAA 412 Query: 118 LPELQNIAGK---RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + + A R + R + E + L+ G EV Y+ AE Sbjct: 413 VFPAFDEALDPINRVFVPRADIATESLSADLSELGWEVEDVVGYRTVRAAPPPAETREAI 472 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + + VV TS ++ L + + + H + V R A+ RE G +A Sbjct: 473 KTGKFDAVVFTSSTTVRNLVGIAGKPH-----KHTVVAAVGIRTAETCREHGLTVDVIAP 527 Query: 235 NAD 237 Sbjct: 528 EPT 530 Score = 54.1 bits (129), Expect = 4e-06, Method: Composition-based stats. Identities = 21/153 (13%), Positives = 41/153 (26%), Gaps = 8/153 (5%) Query: 89 RTTALALHTVSGQKILYPQDREISEV----LLQLPELQNIAGKRALILRGNGGRELIGDT 144 TA + + ++ ++ E L E + + G LI R + Sbjct: 251 PQTAKTAR-LGDAEPVHVAIGKVVEAPEREQLDWYESKPLFGWNILIPRTRDHSATLPSR 309 Query: 145 LTARGAEVTFCECYQRCAI--HYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYR 202 L + GA + VV TS ++ + + Q Sbjct: 310 LQSYGAHSLDVPTISMEPPRTPQQMDKAIRGLVEGRYEWVVFTSANAVRAVSEKLEQIGL 369 Query: 203 EHWL-LHCRLLVVSERLAKLARELGWQDIKVAD 234 + R+ + + E G + V Sbjct: 370 DARAYSGLRIAAIFDSTINALAEWGVRPDFVPS 402 >UniRef50_A0KFH5 Uroporphyrinogen-III synthase n=2 Tax=Aeromonas RepID=A0KFH5_AERHH Length = 244 Score = 186 bits (473), Expect = 5e-46, Method: Composition-based stats. Identities = 101/243 (41%), Positives = 135/243 (55%), Gaps = 7/243 (2%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 LV RP+ EL + LR G PL+E G +L +L + L ++D++ A+S HA Sbjct: 4 LVVRPAAQAAELAALLRQHGHAPLCCPLLETVAGSELHRLPEL---LPQADIVIAVSVHA 60 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 V F L Q + WP DYFA+G+ +A A V Q L P D SE LL LP LQ Sbjct: 61 VNFTHHFLLQTGQTWP-NIDYFAVGQASADAFSEVGIQ-ALSPDDPR-SEGLLALPSLQQ 117 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + GK+ LILRGNGGR+LI TL +RGA V +C Y+R DG WQA + ++ Sbjct: 118 VNGKQVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPALDGDALTCHWQAAGLDSLL 177 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 VTSGE+LQ+L L+P WL L+V S R+A++A G+ I +A A N AL Sbjct: 178 VTSGELLQRLLELVPDQQLP-WLHDRLLVVPSPRVAEMAAAAGFTHITIAQGASNQALTA 236 Query: 244 ALQ 246 AL+ Sbjct: 237 ALE 239 >UniRef50_A3Y6B4 Uroporphyrinogen-III synthetase n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6B4_9GAMM Length = 253 Score = 186 bits (473), Expect = 5e-46, Method: Composition-based stats. Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 10/248 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFALSQ 61 IL+TRP P R +T G + P+IE + + + L D + +S+ Sbjct: 8 ILITRPEPENTLSCERFQTWGAHSLSLPMIEIDALTEQNAAIQSHIFDLDLYDQVIFISK 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDR----EISEVLLQ 117 +AV + + P ++ IG+ T ++ + + Q+ SE LL Sbjct: 68 NAVRYGIEWIEDCWPMLPVGINWVGIGKGTTDFINELGFDLGIKAQEHALSGNTSEALLN 127 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 +Q +AG++ LI+ G GGR + +TL RGA+V Y R I+YD + A Sbjct: 128 QESMQKVAGQKILIMGGEGGRTKLAETLLERGAQVKHLALYSRNKINYDLEQVAEA---E 184 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++++TSGE L+ L + Q ++WL H +L S+R+A +A ELGW+++ A+ AD Sbjct: 185 NCEVILITSGEGLENLVDTLSQHN-KNWL-HKLILTPSQRVADMAIELGWKNVVNANGAD 242 Query: 238 NDALLRAL 245 ++++ AL Sbjct: 243 DNSIYAAL 250 Score = 42.5 bits (99), Expect = 0.011, Method: Composition-based stats. Identities = 15/120 (12%), Positives = 37/120 (30%), Gaps = 4/120 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+ +L L G H + ++ +Q+A +++ S Sbjct: 138 KILIMGGEGGRTKLAETLLERGAQVKH---LALYSRNKINYDLEQVAEAENCEVILITSG 194 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + L Q ++ W + A + + ++ + + + L +L Sbjct: 195 EGLENLVDTLSQHNKNWLHKL-ILTPSQRVADMAIELGWKNVVNANGADDNSIYAALTQL 253 >UniRef50_B0K2L5 Uroporphyrin-III C-methyltransferase n=9 Tax=Thermoanaerobacterales RepID=B0K2L5_THEPX Length = 497 Score = 186 bits (472), Expect = 6e-46, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 83/245 (33%), Gaps = 9/245 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR +++ L G P I+ +P + L + + D S Sbjct: 254 RILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNN--IVKFLEEIHKFDYAVFTSV 311 Query: 62 HAVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V ++ L AIG TA AL + + P++ S L + Sbjct: 312 NDVWSFIEASREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEE-YTSYSLANALK 370 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + GK +L G +++ ++L A V Y+ + + + + Sbjct: 371 KH-VEGKNIALLTSQIGGDILLESLGNC-ANVQKIVAYKNEPNYEIKEKLISELRKG-ID 427 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + V TS + LI + L + ++ + K + G+ + + Sbjct: 428 IAVFTSSSTFNYMHQLIGDEI--NLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSEYTTEK 485 Query: 241 LLRAL 245 L+ + Sbjct: 486 LIEEI 490 Score = 73.3 bits (179), Expect = 7e-12, Method: Composition-based stats. Identities = 22/155 (14%), Positives = 50/155 (32%), Gaps = 6/155 (3%) Query: 95 LHTVSGQK--ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEV 152 + + + D L+ E + + GKR L+ R + + L+ GA+V Sbjct: 219 VRKEGIKNPGVFAVGDVVTLRDRLKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADV 278 Query: 153 TFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRL 211 C I + + V TS + + + L ++ Sbjct: 279 VVCP---TIKITPFLNNIVKFLEEIHKFDYAVFTSVNDVWSFIEASREKRVDLRNLRIKV 335 Query: 212 LVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 + + + A+ + + + + +L AL+ Sbjct: 336 VAIGSKTAEALENIFIYPDIIPEEYTSYSLANALK 370 >UniRef50_Q59335 Uroporphyrinogen-III synthase n=11 Tax=Chlorobiaceae RepID=HEM4_CHLP8 Length = 246 Score = 186 bits (472), Expect = 8e-46, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 80/248 (32%), Gaps = 13/248 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP V L G FP IE P + L + +F S Sbjct: 3 TVLVTRPKHQAAPFVRELEQYGLSTVVFPTIEIRPVAGWN-----VPDLTKFAGIFFTSP 57 Query: 62 HAVAFAQSQLHQQDRKWPRLP---DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 ++V F L Q + +A+G+TT L P+ + L+ Sbjct: 58 NSVQFFLKHLLQTAPDELKNLQQTRVWAVGKTTGQDLEKHGVSIEPLPKIA-DAVNLMAD 116 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-YDGAEEAMRWQAR 177 + I G+ L +RG+ I + + G Y+ D Sbjct: 117 IDPAEIKGQTFLFVRGSLSLGTIPELIAEFGGTCVELTVYENLPPSLEDTQRVKDMLAEG 176 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 ++ + TS + + I ++ + + ++G + + + D Sbjct: 177 KLDCLSFTSPSTAKNFFEAIGSKELSD---SVQIAAIGTTTSGALEKMGIKVDIIPEYFD 233 Query: 238 NDALLRAL 245 + +A+ Sbjct: 234 GPSFAKAI 241 >UniRef50_A1WVU0 Uroporphyrinogen-III synthase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WVU0_HALHL Length = 264 Score = 185 bits (470), Expect = 1e-45, Method: Composition-based stats. Identities = 71/220 (32%), Positives = 105/220 (47%), Gaps = 2/220 (0%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP+ E LV L G W FP ++ + + +D L +SQ+ Sbjct: 10 VIVTRPTHQAEGLVHALEAAGAGVWRFPTLDIIAEPEDAARQEAARRAACADWLIFVSQN 69 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AVA ++ +G+ TA AL +++LYP+ SE LL +L Sbjct: 70 AVAHGLPRIRAAGGPA-GHARCATVGQGTAEALRRNGIEEVLYPRHGATSEDLLAETDLG 128 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 I+ R +I+RG GGR + + L ARGAEV F E Y+R D A +A V +V Sbjct: 129 RISAGRVMIVRGVGGRPYLAEALRARGAEVDFLEVYRRVRPSTDPAPLLEAAEADRVQVV 188 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 V TSGE+L L+ R WL ++V+ ER+A +A Sbjct: 189 VATSGEVLDNFLELVGDRGR-RWLARAGVVVIGERVATMA 227 Score = 48.3 bits (114), Expect = 2e-04, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 26/92 (28%), Gaps = 2/92 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLI-EFSPGQQLPQLADQLAALGESDLLFALS 60 +++ R L LR G + P L + A ++ A S Sbjct: 134 RVMIVRGVGGRPYLAEALRARGAEVDFLEVYRRVRPSTDPAPLLEA-AEADRVQVVVATS 192 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTA 92 + + + R+W IG A Sbjct: 193 GEVLDNFLELVGDRGRRWLARAGVVVIGERVA 224 Score = 46.4 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 40/123 (32%), Gaps = 3/123 (2%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G ++ R E + L A GA V A D A + +A Sbjct: 3 QPLDGTGVIVTRPTHQAEGLVHALEAAGAGVWRFPTLDIIAEPEDAARQEAARRAACADW 62 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD-NADNDA 240 ++ S + I H R V + A+ R G +++ A ++ Sbjct: 63 LIFVSQNAVAHGLPRIRAAGGPAG--HARCATVGQGTAEALRRNGIEEVLYPRHGATSED 120 Query: 241 LLR 243 LL Sbjct: 121 LLA 123 >UniRef50_C9RF91 Uroporphyrinogen III synthase HEM4 n=2 Tax=Methanocaldococcus RepID=C9RF91_METVM Length = 244 Score = 185 bits (470), Expect = 1e-45, Method: Composition-based stats. Identities = 39/249 (15%), Positives = 91/249 (36%), Gaps = 16/249 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP E + L+ FP ++ + L L E + S Sbjct: 1 MKVVITRPKERAEAFSTILKKENFDPIIFPTLKLEYNKDLK------IDLDEYGWIIFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V + L +++++ + AIG TA + + G+ + +E LL+ + Sbjct: 55 PSGVIGLNNILSEKEKENVKDKKIAAIGEKTAKMVKKIFGKYPDIVPKQYTAECLLEEIK 114 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE---EAMRWQAR 177 + R L+ R+++ + L A Y+ + Sbjct: 115 KRADKNDRFLVPTTPSTRDILKNNLNA-----DLVFVYKSVEPENLKENMEVLKETLKNE 169 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 E ++ TSG + + + + + + + ++ + AK+ ++ G + K+ D Sbjct: 170 ERFIITFTSGLTAKNFFKYVDDEFYQ-MIKNNYIVAIGPITAKVIQKFGI-NPKIPDKYT 227 Query: 238 NDALLRALQ 246 + +L ++ Sbjct: 228 IEGMLEVIK 236 >UniRef50_A9KDC7 Uroporphyrinogen-III synthase n=5 Tax=Coxiella burnetii RepID=A9KDC7_COXBN Length = 268 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 70/264 (26%), Positives = 104/264 (39%), Gaps = 29/264 (10%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPG----------------QQLPQLAD 45 +I++TRP GE L + G FP + P ++ D Sbjct: 10 TIMITRPEGQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDD 69 Query: 46 QLAA---LGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK 102 ++ L SD+L LS +AV + AIG TA AL Sbjct: 70 KMTKAGFLNSSDILIFLSANAVKH------SPILNFKAEQKLVAIGTGTAAALFQRGLSV 123 Query: 103 ILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA 162 P + SE LL LP L + GK I G R + + L RGA V Y+R Sbjct: 124 DAVP-EHFSSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYRRER 182 Query: 163 IHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 + + + +V TS E LQ L +L +HWL L+V+S+R+ LA Sbjct: 183 PVVNKKTI-DALTHQTLHAIVSTSAESLQNLCTLFESH--QHWLHRIPLVVISKRMENLA 239 Query: 223 RELGWQDIKVADNADNDALLRALQ 246 + G+ + +ADN A+++ L Sbjct: 240 KSQGFHLVLLADNPGEKAIIKVLS 263 >UniRef50_A4CFD4 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=1 Tax=Pseudoalteromonas tunicata D2 RepID=A4CFD4_9GAMM Length = 614 Score = 183 bits (466), Expect = 3e-45, Method: Composition-based stats. Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 11/246 (4%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ILVTRP G ELV++L+ LG A FPL+ P LA LGE+D L +SQ Sbjct: 4 ILVTRPDTKGAELVAQLKKLGHHAISFPLLALEPLAVSS---AALAPLGEADKLIFISQD 60 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 AV L+ P +FA+G TA + + G K + + SE LL L ELQ Sbjct: 61 AVKA----LYALKPNLKHQPQFFAVGEKTAAVIAELFGVKARIAK-PQDSEGLLALKELQ 115 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 +I + ++L+G GR LI L RGA V Y+R + + +WQ +++ + Sbjct: 116 HIEQQNIVLLKGQDGRPLIAQKLKQRGAFVHAVVLYRRQPVKGVASGWIKQWQQQKIDSI 175 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW--QDIKVADNADNDA 240 V+TS + ++ + + WL CR V SER+A + +I++ A ++A Sbjct: 176 VLTSNAAVDAIFRELAE-NEVKWLKTCRFYVASERIANYLSQFAIAANNIQICAGASDEA 234 Query: 241 LLRALQ 246 +L A+ Sbjct: 235 ILTAIS 240 Score = 44.1 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 39/124 (31%), Gaps = 3/124 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I++ + + +L+ G L P + + + + D + S Sbjct: 121 NIVLLKGQDGRPLIAQKLKQRGAFVHAVVLYRRQPVKGVASGWIKQWQQQKIDSIVLTSN 180 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSG--QKILYPQDREISEVLLQLP 119 AV +L + + KW + ++ A L + I E +L Sbjct: 181 AAVDAIFRELAENEVKWLKTCRFYVASERIANYLSQFAIAANNIQICAGASD-EAILTAI 239 Query: 120 ELQN 123 Q+ Sbjct: 240 SQQD 243 >UniRef50_Q474V0 Putative uncharacterized protein n=1 Tax=Ralstonia eutropha JMP134 RepID=Q474V0_RALEJ Length = 689 Score = 183 bits (466), Expect = 4e-45, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 106/273 (38%), Gaps = 31/273 (11%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L + L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQAAGLDVLGFPLLSIGPAADDAPLRAALARLDQFALVIFVSP 64 Query: 62 HAVAFAQSQLH----QQDRKWPRLPDYFAIGRTTALALHTVSGQ----KILYPQD----- 108 +A+ +A L +WP +G + +AL +++ P Sbjct: 65 NAIQYAVDALAVVQGIAAAQWPPGVPVAVVGPASVMALAERGIVAPDYRVIAPAGADGNG 124 Query: 109 ----------REISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECY 158 R SE L E + G+ LI+RGNGGR+ +GD L GA+VT E Y Sbjct: 125 TNGGANCEEARFDSEALWAQLEPAALQGRSVLIVRGNGGRDWLGDRLREAGADVTAVEAY 184 Query: 159 QRCAIHYDGAEEAMRWQ----AREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRL 211 QR + ++TS E ++ L +L L + Sbjct: 185 QRTLPEPTAMQWQAVRDGLSPGAAPQAWLLTSSEAVRNLETLARHNLSPQELATLKQVQC 244 Query: 212 LVVSERLAKLARELGWQDIKVADNADNDALLRA 244 + R+A+ A+ LG+ I A + LL A Sbjct: 245 IAPHARIAEQAQALGFTRILRAA-PGDAGLLAA 276 >UniRef50_P48246 Uroporphyrinogen-III synthase n=23 Tax=Pseudomonadaceae RepID=HEM4_PSEAE Length = 251 Score = 183 bits (465), Expect = 4e-45, Method: Composition-based stats. Identities = 67/233 (28%), Positives = 111/233 (47%), Gaps = 7/233 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+TRP L + L G + PL+ P ++ P+ + L + +S+ Sbjct: 5 RLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSK 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A +L + + P+ + ++G TA L + YP+ + SE LL LP Sbjct: 65 PAARLGLERLDRYWPQPPQQT-WCSVGAATAAILEAYGL-DVTYPEQGDDSEALLALPAF 122 Query: 122 QN---IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 Q+ + + LI+RG GGRE + + L +G +V + Y+R A Y E R +A Sbjct: 123 QDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAER 182 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + +VV+SG+ LQ L+ L + E + L V S R+A++ARELG Q + Sbjct: 183 LNGLVVSSGQGLQNLYQLAAADWPE--IGRLPLFVPSPRVAEMARELGAQRVI 233 Score = 41.0 bits (95), Expect = 0.033, Method: Composition-based stats. Identities = 17/119 (14%), Positives = 35/119 (29%), Gaps = 2/119 (1%) Query: 125 AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVV 184 +G R L+ R + + +L G + + + + VVV Sbjct: 2 SGWRLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVV 61 Query: 185 TSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 S + + +++ + V A + G D++ALL Sbjct: 62 VSKPAARLGLERLDRYWPQP--PQQTWCSVGAATAAILEAYGLDVTYPEQGDDSEALLA 118 >UniRef50_P42452 Uroporphyrinogen-III synthase n=16 Tax=Cyanobacteria RepID=HEM4_SYNE7 Length = 264 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 7/250 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL TR + ++LR G P +E P L + +AA+ + D L S Sbjct: 10 TILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIADFDWLILASA 69 Query: 62 HAVAFAQSQLHQQDRKWPR-LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV Q +L Q + W +G+ TA L G+ P + I+E L++ Sbjct: 70 NAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPE-FIAESLVEHF- 127 Query: 121 LQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 Q +AG+R L R GGRE I L ++GA V Y+ + + + + Sbjct: 128 PQPVAGQRLLFPRVETGGREQITQALQSQGAIVVEVPAYESRCPSQIPDDALIALRQAHL 187 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLARELGWQDIKVADNA 236 ++ TS + ++ L+ W + + + + +EL + A Sbjct: 188 NLISFTSSKTVRNFCQLMASNLGVDWSARISGVAIASIGPQTSITCQELLGRVEVEAQEY 247 Query: 237 DNDALLRALQ 246 D LL A++ Sbjct: 248 TLDGLLLAIE 257 Score = 52.2 bits (124), Expect = 2e-05, Method: Composition-based stats. Identities = 18/125 (14%), Positives = 41/125 (32%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 Q + GK L R G L A GA V + + + Sbjct: 1 MAEQPLIGKTILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIAD 60 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 +++ S ++ + + + + C + VV ++ A++ G + + Sbjct: 61 FDWLILASANAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPEFIA 120 Query: 239 DALLR 243 ++L+ Sbjct: 121 ESLVE 125 >UniRef50_O26268 Putative uroporphyrinogen-III synthase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM4_METTH Length = 253 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 82/246 (33%), Gaps = 7/246 (2%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 VTRP E V + G A P +E L + E DL+ SQ A Sbjct: 2 AVTRPPERSAEAVELIEGAGGRALVAPTLELKE-AHTESLREVCRRADEWDLVIFTSQAA 60 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 V + K + IG TA + + P+D +E LL N Sbjct: 61 VESLFQLCREFAGKIRKDCLVAVIGPRTARVAGEHGLRVDIVPED-YTAEGLLDALTGLN 119 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY--DGAEEAMRWQAREVTM 181 I G + + R R+++ L GAEV E Y+ E +V Sbjct: 120 IEGWKVALPRTLSARKVLPRGLEMMGAEVLVAEAYRSGLPEDTGPAEELIDGLLDGKVDA 179 Query: 182 VVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V TS ++ L+ + +E L ++ + + E G + + Sbjct: 180 VTFTSPLTVENLFKIAGNRRKELIEVLKRVKVAAIGPITLRKLEEHGITAV-TPERYTVK 238 Query: 240 ALLRAL 245 ++ AL Sbjct: 239 DMIAAL 244 >UniRef50_B2UXC3 Uroporphyrinogen III synthase/methyltransferase n=7 Tax=Clostridium RepID=B2UXC3_CLOBA Length = 491 Score = 181 bits (461), Expect = 1e-44, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 80/246 (32%), Gaps = 14/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I VTR L +LR +G IE L + L D + S Sbjct: 251 NICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTANN--LDSYMGDLENYDHIVFTSV 308 Query: 62 HAVAFAQSQLHQQDRKWPRL-PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++V L + +L AIG+ T AL I L+++ + Sbjct: 309 NSVDIFFDYLIENKYDIRKLQAKVSAIGKATWQALERRGIIC-FVKAREFIGAGLIKVLK 367 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ LI + + I D L+ GA V Y + EV Sbjct: 368 PHVKENEKVLIPCSSLAKSDIADELSNVGANVDRVFIYDTV-----KGRVRNKRAFDEVD 422 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V TS + + ++ + +++ + R K ELG + + D Sbjct: 423 IVFFTSPSTVYNMIDMVG----LDAIKEKQVIAIGTRTNKPLEELGIK-AYICKEHSQDG 477 Query: 241 LLRALQ 246 L ++ Sbjct: 478 FLNEIE 483 >UniRef50_Q31D67 Uroporphyrinogen-III synthase n=7 Tax=Prochlorococcus marinus RepID=Q31D67_PROM9 Length = 265 Score = 181 bits (461), Expect = 1e-44, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 93/253 (36%), Gaps = 10/253 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I++TR ++ + G + FP I L L + L + + + S Sbjct: 12 NIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQINDFHWIIFSSS 71 Query: 62 HAVAFAQSQLHQQD---RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + + F +L ++ + +G TA L + P + ++E L+ Sbjct: 72 NGIKFVDKRLRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPE-YVAESLIDN 130 Query: 119 PELQNIAGKRALILRGN-GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + G R + R GGR+LI D G+ V Y+ E R Sbjct: 131 FPISGY-GLRVFLPRVQTGGRDLIADQFRKAGSRVFEVAAYETRCPDSIPEETIDIIVNR 189 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLL---HCRLLVVSERLAKLARELGWQDIKVAD 234 +V + +SG+ + L+ + + + WL R L + + K+ +++ + A Sbjct: 190 KVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKIFGRVDSQAQ 249 Query: 235 NADNDALLR-ALQ 246 D LL A+ Sbjct: 250 KYTFDGLLDVAIS 262 Score = 59.9 bits (144), Expect = 7e-08, Method: Composition-based stats. Identities = 16/127 (12%), Positives = 43/127 (33%), Gaps = 2/127 (1%) Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + + +I R G I T++GA + + Q + Sbjct: 3 IVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQIND 62 Query: 179 VTMVVVTSGEMLQQLWSLIP--QWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 ++ +S ++ + + Q + ++ VV E+ A+ + G + + Sbjct: 63 FHWIIFSSSNGIKFVDKRLRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPEY 122 Query: 237 DNDALLR 243 ++L+ Sbjct: 123 VAESLID 129 >UniRef50_Q0VM29 Uroporphyrinogen-III synthase n=2 Tax=Alcanivorax RepID=Q0VM29_ALCBS Length = 243 Score = 181 bits (459), Expect = 2e-44, Method: Composition-based stats. Identities = 69/244 (28%), Positives = 104/244 (42%), Gaps = 16/244 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP + L+ L G H P + P + L L +F S Sbjct: 9 RVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASV 68 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A A S + +WP + A+GR TA L + PQ +E +L LP L Sbjct: 69 NAARLALSAMADLWPQWPVGVHWLAVGRATAAELESWHL-PATVPQQGFNTEAVLALPCL 127 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + K+ LI RG+ GREL+ TL +RGA V Y+R A E Sbjct: 128 QQLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKAASP-------VLIPAETDW 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V++TS + Q + +P C ++ ER+A + R D+ VA +A ++ + Sbjct: 181 VMITSVQGWQAIGGSVPPC--------CGVVAAGERVADVVRAEHSGDVSVAASAHDEDM 232 Query: 242 LRAL 245 L AL Sbjct: 233 LSAL 236 >UniRef50_UPI0001C42100 uroporphyrinogen-III synthase HemD n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42100 Length = 258 Score = 180 bits (458), Expect = 3e-44, Method: Composition-based stats. Identities = 39/250 (15%), Positives = 77/250 (30%), Gaps = 9/250 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I +TRP + + G A P +E + L + + E D L S Sbjct: 4 KIAITRPQERSKAAKEFIENYGSEAIIVPTLELK-LENTESLKNLMEKSNELDWLIFTSV 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 ++ K IG TA + P+D +E LL+ E Sbjct: 63 SSIESIFEFYPDFLDKLNPECKIATIGTKTAELGIKKGLPIDIIPKD-YTAEGLLEEFER 121 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQAREV 179 ++ K + R R ++ + L GA V E Y+ + ++ Sbjct: 122 IDLNNKNVGVPRTFSARTILPEGLKNMGANVILAESYKSVIPEDTSKIEKLIQCILDEKI 181 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLH----CRLLVVSERLAKLARELGWQDIKVADN 235 + TS + L+ + +++ + + + + +LG I Sbjct: 182 DGITFTSPLTVSNLFEIAKDEDKDNLVEKLSTTTLTVAIGPITGNILNQLGVNHIY-PKR 240 Query: 236 ADNDALLRAL 245 ++ + Sbjct: 241 YTVKDMIDLM 250 >UniRef50_C5EV70 Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=3 Tax=Clostridiales RepID=C5EV70_9FIRM Length = 512 Score = 180 bits (457), Expect = 4e-44, Method: Composition-based stats. Identities = 36/256 (14%), Positives = 69/256 (26%), Gaps = 16/256 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + +T +L + L G ++ + + L L S Sbjct: 255 RVGITGTEQFAGKLAAALSEQGAQVSWLVNMKVEDHIEEAPMQAAYRNLPSYTWLVFTSA 314 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V L + R + IG T L P D ++ L Sbjct: 315 NGVRLFFQGLFKDGRDCRCLGHVKFAVIGDGTGRELSGYGFNADYMP-DAYCAKALADGL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G R LI R GG ++ TL G Y+ + Sbjct: 374 VHAVSPGDRLLIARSAGGSPILAQTLLNAGIHFDDIVLYE-VTGQPSASFIPEEVM--GF 430 Query: 180 TMVVVTSGEMLQQLWSLIPQ----------WYREHWLLHCRLLVVSERLAKLARELGWQD 229 + S ++ + + Q + +L+ + A+ G++ Sbjct: 431 DYITFASASGVRAFFDCLTQGGTGDKAVGIQGPAVHPKNPKLVCIGAVTARELERQGYKA 490 Query: 230 IKVADNADNDALLRAL 245 A + L++A+ Sbjct: 491 DITAAQYHIEGLVKAI 506 Score = 54.1 bits (129), Expect = 4e-06, Method: Composition-based stats. Identities = 22/152 (14%), Positives = 48/152 (31%), Gaps = 1/152 (0%) Query: 95 LHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTF 154 + + + ++ +AG+R I + L+ +GA+V++ Sbjct: 222 VREAGLGTPAIIVVGDTAAYEMKYRTAGPLAGRRVGITGTEQFAGKLAAALSEQGAQVSW 281 Query: 155 CECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLV 213 + + +A T +V TS ++ + L L H + V Sbjct: 282 LVNMKVEDHIEEAPMQAAYRNLPSYTWLVFTSANGVRLFFQGLFKDGRDCRCLGHVKFAV 341 Query: 214 VSERLAKLARELGWQDIKVADNADNDALLRAL 245 + + + G+ + D AL L Sbjct: 342 IGDGTGRELSGYGFNADYMPDAYCAKALADGL 373 >UniRef50_A3RYV4 UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III C-methyltransferase n=6 Tax=Ralstonia RepID=A3RYV4_RALSO Length = 1065 Score = 180 bits (456), Expect = 5e-44, Method: Composition-based stats. Identities = 63/242 (26%), Positives = 100/242 (41%), Gaps = 14/242 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP LV+ L G FPL++ +P L L LA L+ +S + Sbjct: 394 VVVTRPRAQALMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 453 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK---------ILYPQDREISE 113 AV A + + + +WP+ +G +A AL + + R+ SE Sbjct: 454 AVQQAFAAMPE-GFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSE 512 Query: 114 VLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR-CAIHYDGAEEAM 172 L + ++G+ LI+RGNGGRE + D L G V E Y+R + A A+ Sbjct: 513 ALYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAAL 572 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW---LLHCRLLVVSERLAKLARELGWQD 229 R +TS E ++ L SL L R+ + A+ LG++D Sbjct: 573 REVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRD 632 Query: 230 IK 231 + Sbjct: 633 VT 634 >UniRef50_B2V748 Uroporphyrinogen III synthase HEM4 n=1 Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=B2V748_SULSY Length = 237 Score = 179 bits (455), Expect = 6e-44, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 93/248 (37%), Gaps = 21/248 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I++TR + EE+ G FPLI F P + L + L S+ Sbjct: 3 NIIITREASGFEEVKDLFIKAGFNPISFPLIRFEPVEIKN------FNLEDYKYLIFTSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE- 120 +AV + SQ+ + D A+G TA L + + I+ P + +E L E Sbjct: 57 NAVKYFFSQIPKID------KKIIAVGEKTAKYLEKLGYKDIIVP-EVFSAEGLKAYFEK 109 Query: 121 -LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA-IHYDGAEEAMRWQARE 178 + K+ ++R + G DTL ++ Y+ I + E + + Sbjct: 110 NIDTFKDKKIALIRASEG----MDTLLNSNFKIDLIPVYETKLNIPENVDEIKSLIENEK 165 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V +V +S + ++ + + L + + + G++ V D Sbjct: 166 VYAIVFSSPSTFKGFLNIFKEE-SKKLLDKMLTVAIGKTTKNFIESQGFKVDVVPDKFTF 224 Query: 239 DALLRALQ 246 + +++ L+ Sbjct: 225 EEIVKKLK 232 >UniRef50_B3DZQ5 Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase n=3 Tax=cellular organisms RepID=B3DZQ5_METI4 Length = 514 Score = 179 bits (454), Expect = 9e-44, Method: Composition-based stats. Identities = 48/247 (19%), Positives = 87/247 (35%), Gaps = 6/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGE-SDLLFALS 60 ++VTR + +L+ LG P I P + +L + D L S Sbjct: 260 RVVVTRTKEGSARIAKKLQELGAEVLEIPTIRIVPSSLGDEQIRRLKKIEAFYDWLLFTS 319 Query: 61 QHAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 V + D + + AIG TTA A+ + P ++ S L + Sbjct: 320 PTGVEIFFGHYLRLTGDIRGLKGIKIGAIGLTTAQAIGRYHLAVEVIP-EKFTSMDLARC 378 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 +NI G+R L+ R E I LT+ GA V Y D ++Q Sbjct: 379 FLGKNIEGERFLLPRSTMADEGIVKFLTSLGACVEQWALYDIQPETEDFRGGREKFQKEG 438 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ S ++ L + L +++ + + + ++L + + + Sbjct: 439 ADWILFASASSVKYWNRLNLSCHDTSLL--PKVISIGPQTTRALQDLHQEVYRESKIHTI 496 Query: 239 DALLRAL 245 D L+ L Sbjct: 497 DGLIETL 503 Score = 76.0 bits (186), Expect = 1e-12, Method: Composition-based stats. Identities = 17/124 (13%), Positives = 37/124 (29%), Gaps = 2/124 (1%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 LQ E + + G+R ++ R G I L GAEV + + + Sbjct: 248 LQWFEKKPLYGQRVVVTRTKEGSARIAKKLQELGAEVLEIPTIRIVPSSLGDEQIRRLKK 307 Query: 176 AREV-TMVVVTSGEMLQQLW-SLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 ++ TS ++ + + L ++ + A+ + Sbjct: 308 IEAFYDWLLFTSPTGVEIFFGHYLRLTGDIRGLKGIKIGAIGLTTAQAIGRYHLAVEVIP 367 Query: 234 DNAD 237 + Sbjct: 368 EKFT 371 >UniRef50_B8KSU6 Putative uncharacterized protein n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KSU6_9GAMM Length = 679 Score = 178 bits (453), Expect = 1e-43, Method: Composition-based stats. Identities = 79/245 (32%), Positives = 125/245 (51%), Gaps = 7/245 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++++TRP L + L G + P++ P P D L AL ++DL +S Sbjct: 4 TVILTRPQEDSARLAAILAERGWDVFVQPMLRMEPLA--PAAIDALPALTDNDLAIFISA 61 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV L ++ R A+GR TA L + DRE SE LL LP L Sbjct: 62 NAVRQGLPHLAERLRD--AGMVSLAVGRRTAQELEAAGL--PVMTPDREDSEGLLALPAL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + I+G R L+++G GGR ++ +TL RGAEV CYQR D + A R + Sbjct: 118 REISGHRVLLVKGEGGRAVLAETLRTRGAEVIEFVCYQRVNESLDATDFAGELAKRRPLV 177 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 + +S + L+++ L+ + + + + ++V SER+A++A ELGWQ + A NA ++A Sbjct: 178 IQASSEQTLRRVTELLAEGGQPNLVAE-NVVVPSERVAQVAAELGWQHVITAPNAGDEAF 236 Query: 242 LRALQ 246 LR L+ Sbjct: 237 LRVLE 241 >UniRef50_Q3IF71 Uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal) n=2 Tax=Alteromonadales RepID=Q3IF71_PSEHT Length = 616 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 66/248 (26%), Positives = 114/248 (45%), Gaps = 11/248 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++IL+TRP G L +L G A FP+++ +L+ L +D + +S Sbjct: 2 LNILITRPQGKGAALAQQLEQAGYQASLFPVLKIEYLTPDSI---ELSPLTNADKIIFVS 58 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Q AV L + ++ +G+ TA ++ V G + P+ + SE LL L Sbjct: 59 QDAV----LALSELKPDINIKAQFYGVGQQTADTIYEVFGVRAAVPK-QHDSEGLLALKS 113 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L ++ ++++G GGR I TL RGA + C YQR I + WQ++ V Sbjct: 114 LADVDSCNIVLVKGIGGRPDIAKTLKQRGAFLNNCVVYQRTPIDPEPNNWIDHWQSQNVH 173 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ--DIKVADNADN 238 +V+TS + ++ + R+ WL CR V SER+ ++ +I +A A + Sbjct: 174 GIVITSNAAVDAIFKNLAAPQRQ-WLQQCRFYVASERIGAYLQQHQVSSANIHIAAGASD 232 Query: 239 DALLRALQ 246 +A+ + Sbjct: 233 NAMFTCIN 240 >UniRef50_O67647 Putative uncharacterized protein n=1 Tax=Aquifex aeolicus RepID=O67647_AQUAE Length = 250 Score = 178 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 36/245 (14%), Positives = 85/245 (34%), Gaps = 17/245 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR ++ G PLI+ L L E D + S+ Sbjct: 15 RVILTRELEDIKKDKPLFEREGFKVLELPLIQT------KVLEFNLPD-EEFDYIVFQSK 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV A+G+ TA L + + P++ E ++ L++L + Sbjct: 68 KAVKIFL-----GKVNLKGNKKIVAVGKKTAEELEKLGYKADFIPEN-ESAKGLIELFK- 120 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + + LI R GR + L EV + Y + Y E + Sbjct: 121 -RLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKG--DF 177 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ S ++ ++ + L + + + + + ++ +++ ++ + + Sbjct: 178 IIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDI 237 Query: 242 LRALQ 246 ++ L+ Sbjct: 238 VKKLK 242 Score = 64.1 bits (155), Expect = 4e-09, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 44/123 (35%), Gaps = 3/123 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R EL+ L+ + + + + L L + D + S Sbjct: 126 KVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTRE--ELLEKLNKGDFIIFYSP 183 Query: 62 HAVAFAQSQLHQQDR-KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 AV + L K + AIG+TT L S + ++ + +++ +L E Sbjct: 184 SAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKKLKE 243 Query: 121 LQN 123 L Sbjct: 244 LAR 246 >UniRef50_UPI0001C35DE2 uroporphyrinogen III synthase/methyltransferase (HemD+CobA) n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE2 Length = 504 Score = 177 bits (449), Expect = 3e-43, Method: Composition-based stats. Identities = 39/247 (15%), Positives = 73/247 (29%), Gaps = 6/247 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + VT +L L G +E + + L + + S Sbjct: 255 RVAVTGTGLLAAKLRKSLEEAGASTECVLSLELESCRSGEAMKAAYERLADYGWIVFTSA 314 Query: 62 HAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 +AV L + R + A+G+ TA L P++ + L + Sbjct: 315 NAVREFFLGLLESGRDNRSVGHVKFAAVGKGTAKELLRYGFTTDYIPEE-FCAAALARGL 373 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + G+R LI R G + L G Y E + + + Sbjct: 374 KDVVKDGERLLIPRSLKGSPELNGILDGAGIRYDDVVLYNVAERKQGEKELSEALK--KA 431 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + SG + + + L R++ + + AK E G + A + Sbjct: 432 DYLTFASGSGVDAFFENAGE-DVTALLAGIRVVCIGDITAKKLEEHGRKADVTASRFTVE 490 Query: 240 ALLRALQ 246 + A+ Sbjct: 491 GMTEAVS 497 >UniRef50_B3QWI2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QWI2_CHLT3 Length = 248 Score = 176 bits (448), Expect = 4e-43, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 86/250 (34%), Gaps = 15/250 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++LVTRP L++ L FP IE + L L +F S Sbjct: 3 TVLVTRPKDQAGSLIAALSKFNLGCELFPTIEIAAVPGWS-----LPGLSGYAGIFFTSV 57 Query: 62 HAVAFAQSQLHQQDRKWPR---LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 ++V + + L + ++ R FA+G TA AL + P + L+ + Sbjct: 58 NSVNYLCTPLQKDFPEFAREINKLKVFAVGVKTAKALAKFNISTEELPSQAY-ATDLMAM 116 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM---RWQ 175 + + I + L +RG +I ++ G Y+ E + Sbjct: 117 IKPEEIQNNKFLFIRGTLSLGIIPAEISKHGGLCDEITVYENKIATPPPDELVRIKSLLE 176 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 ++ +V TS + L+ + ++ + + ++ + D Sbjct: 177 QGKIDCIVFTSPSTAINFFQLL---NIQSLPEKTKVASIGTTTSGALTDMNIATDIMPDY 233 Query: 236 ADNDALLRAL 245 + ++ L A+ Sbjct: 234 STSEGLAEAI 243 >UniRef50_A8UVV3 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8UVV3_9AQUI Length = 244 Score = 175 bits (445), Expect = 9e-43, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 74/238 (31%), Gaps = 17/238 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR E PLI P + + S Sbjct: 8 RVILTRSVEDIERDRKLFEKYRFEVVELPLIRTEPLDFQVP-------KDSYEYVVFQSA 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV P+ A+G T L + + L P+D +E ++ L Sbjct: 61 KAVKHFLKS-----SDIPKGVKVIAVGNRTREELERLGYKVWLVPKD-MSAEGVVNEFPL 114 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G+ LI R GR+ + L+++G V Y+ + Y E + Sbjct: 115 G--RGETVLIPRSEQGRDEAVEGLSSKGYRVVTINVYRTSKVSYSEEEVVSILKGGGF-- 170 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V S ++ ++ + + + L ++ + + K + G V + Sbjct: 171 IVFASPSAVRSFFANLRKGTAKAVLNDLVVVSIGKTTKKELEKFGVTPAIVPPKPLME 228 Score = 55.2 bits (132), Expect = 2e-06, Method: Composition-based stats. Identities = 14/117 (11%), Positives = 33/117 (28%), Gaps = 13/117 (11%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTS 186 KR ++ R E EV + + + + VV S Sbjct: 7 KRVILTRSVEDIERDRKLFEKYRFEVVELPLIRTEPLDFQVPK-------DSYEYVVFQS 59 Query: 187 GEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 + ++ +++ V R + LG++ V + + ++ Sbjct: 60 AKAVKHFLK------SSDIPKGVKVIAVGNRTREELERLGYKVWLVPKDMSAEGVVN 110 >UniRef50_C1AA39 Putative uroporphyrinogen-III synthase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA39_GEMAT Length = 259 Score = 175 bits (445), Expect = 1e-42, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 84/246 (34%), Gaps = 7/246 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I VTR G L LR +G PL P L L L D + S Sbjct: 9 RIAVTRTVERGGPLADALRRVGATVHEIPLTHIEPL-DAAPLHAALRELAHYDWVLLTSV 67 Query: 62 HAVAFAQSQLHQQDRKWP-RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + + + +G TTA A + + +R +E +L Sbjct: 68 NAVERLAQAVREVGAESVMESRRLAVVGSTTAAACESHGWRLPTVQPERMQAEGVLDDLA 127 Query: 121 LQ-NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + ++ G R L G R+++ + L A GA V Y+ ++ EV Sbjct: 128 SRSDVEGSRVLYPAAAGARDVLPEGLRALGAVVDVIATYRTVPDAAGQERMLALVESGEV 187 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V + + + L +P + + A+ AR G+ + + Sbjct: 188 DLVTLAAPSAMDALLDALP----PERASRLPVACIGPVTARAARLAGFPVKVESTAPTVE 243 Query: 240 ALLRAL 245 +R++ Sbjct: 244 GWVRSI 249 Score = 66.0 bits (160), Expect = 1e-09, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 40/122 (32%), Gaps = 4/122 (3%) Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMV 182 +AG R + R + D L GA V D A + V Sbjct: 5 LAGVRIAVTRTVERGGPLADALRRVGATVHEIPL--THIEPLDAAPLHAALRELAHYDWV 62 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIKVADNADNDAL 241 ++TS +++L + + E + RL VV A GW+ + + + Sbjct: 63 LLTSVNAVERLAQAVREVGAESVMESRRLAVVGSTTAAACESHGWRLPTVQPERMQAEGV 122 Query: 242 LR 243 L Sbjct: 123 LD 124 >UniRef50_A8VZH5 PhoU family protein n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VZH5_9BACI Length = 264 Score = 175 bits (443), Expect = 2e-42, Method: Composition-based stats. Identities = 43/251 (17%), Positives = 82/251 (32%), Gaps = 11/251 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL TR + L RL G PLI + + + + A +D++ S+ Sbjct: 9 RILNTRAPHQQKALTDRLTAWGADVVELPLIRVERVKGV-SVREFREAFEAADVVVFTSR 67 Query: 62 HAVAFAQSQLHQQDR-----KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +AV L + + + A+G T L + P D + L Sbjct: 68 NAVEVTMDLLKEACQTDDYTRCFEGKVIAAVGEKTGDVLMASGLTPSIMP-DVFEAGHLA 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + Q G R R+ + LT G VT Y + + ++ Sbjct: 127 RSIVDQTAPGAEIFYPRSEKARKTLPKALTEAGRHVTELVIYTTKSQTIPSDKITELFEG 186 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAREL-GWQDIKVADN 235 + ++ S +Q + + R V+ E + R + + V + Sbjct: 187 DGLDVITFMSPTAVQSFFQQMDPALVPD---DVRFAVIGEVTERALRPYVKEERLIVPER 243 Query: 236 ADNDALLRALQ 246 + ++RA++ Sbjct: 244 YTLEDMIRAIE 254 Score = 57.2 bits (137), Expect = 4e-07, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 49/128 (38%), Gaps = 7/128 (5%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-YDGAEEAMRWQAREVTM 181 ++GKR L R ++ + D LTA GA+V + + E ++A + Sbjct: 4 PLSGKRILNTRAPHQQKALTDRLTAWGADVVELPLIRVERVKGVSVREFREAFEAA--DV 61 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHC----RLLVVSERLAKLARELGWQDIKVADNAD 237 VV TS ++ L+ + + C + V E+ + G + D + Sbjct: 62 VVFTSRNAVEVTMDLLKEACQTDDYTRCFEGKVIAAVGEKTGDVLMASGLTPSIMPDVFE 121 Query: 238 NDALLRAL 245 L R++ Sbjct: 122 AGHLARSI 129 >UniRef50_Q0EX10 Putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EX10_9PROT Length = 263 Score = 174 bits (442), Expect = 2e-42, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 86/248 (34%), Gaps = 10/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TR + L +R G V FP + + +A L + S Sbjct: 10 RILLTRAAAQLPALAEMVRRRGAVPVAFPCLAVESMPDT--IMQAIAKLERFSDVLFTSC 67 Query: 62 HAVAFAQSQLHQQDRK---WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 + V+ L A+G TA L+ + + P+ ++ Sbjct: 68 NGVSSVVDALGSHGMDAAALFAPMRVAAVGNQTADCLNQHGIRTDIVPETASQDGLVDAY 127 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + +R L R GRE + + LT RG EV Y+ H D ++ + E Sbjct: 128 LQSGLP--ERLLFFRAEEGREALAEALTERGIEVETVAAYRTICPHDDASDVIAMLRDGE 185 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V V++ S + + + +S+++A A G VA +A Sbjct: 186 VDAVLLGSARACLHYLQRVGDATLAARPVS---VAISQKMAAAAMCGGLHVQLVAKSASF 242 Query: 239 DALLRALQ 246 +A+L L Sbjct: 243 EAMLDVLS 250 Score = 62.9 bits (152), Expect = 8e-09, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 42/126 (33%), Gaps = 6/126 (4%) Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVT 180 Q +AG+R L+ R + + + RGA C A+ + Sbjct: 4 QPLAGRRILLTRAAAQLPALAEMVRRRGAVPVAFPC---LAVESMPDTIMQAIAKLERFS 60 Query: 181 MVVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V+ TS + + + + R+ V + A + G + V + A Sbjct: 61 DVLFTSCNGVSSVVDALGSHGMDAAALFAPMRVAAVGNQTADCLNQHGIRTDIVPETASQ 120 Query: 239 DALLRA 244 D L+ A Sbjct: 121 DGLVDA 126 >UniRef50_C1DT10 Uroporphyrinogen-III synthase n=2 Tax=Sulfurihydrogenibium RepID=C1DT10_SULAA Length = 241 Score = 172 bits (437), Expect = 7e-42, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 90/250 (36%), Gaps = 20/250 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+TR EE+ S G FP I+F L + D L S+ Sbjct: 3 NVLITREKGQFEEVKSIFEKEGFNPIPFPTIKFEKLP----LDNF--DEKNYDYLIFTSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE- 120 +AV F D + + A+G TA L + I P D E L + Sbjct: 57 NAVKFFLE-----DIEVDKSKPVIAVGSKTANYLKKEGFKNIEIP-DAFSGEGLKDYIDK 110 Query: 121 -LQNIAGKRALILRGNGGRELIGDTLTARGAE--VTFCECYQRCA-IHYDGAEEAMRWQA 176 L GK+ ++R G +++ L G + V Y+ I + E + Sbjct: 111 NLDRFKGKKFGLIRALEGSQVL---LNQSGKDYFVQLLPIYKTTYNIPDNTEEIEKLFLK 167 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +E+ VV +S ++ + +L + + +K + G++ V Sbjct: 168 KEIYAVVFSSPSTFYGFLNVFGVEKSKKFLEDVLVCTIGTTTSKALEDKGFKVNIVPQIF 227 Query: 237 DNDALLRALQ 246 + +++ L+ Sbjct: 228 TFEEIVKLLK 237 >UniRef50_A6GI22 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GI22_9DELT Length = 512 Score = 172 bits (437), Expect = 8e-42, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 88/259 (33%), Gaps = 15/259 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ--QLPQLADQLA--ALGESDLLF 57 ++VTR + L+ L G A FP +E + + + L LA L + + Sbjct: 249 RVVVTRAARQSGGLLHALAGAGADAVAFPCLEVAAPEPAEREALDAALAPDRLAGLEGVI 308 Query: 58 ALSQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVL 115 S + L + + AIG TA + L P SE L Sbjct: 309 VSSPNGADALFDALARLNLDARAFAGKLLAAIGTGTAARCQAKGLRPDLIPAKAR-SEGL 367 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM--- 172 ++L + + G R L +R + GR+L+ + ++ G + Y+ G Sbjct: 368 IELLRARGLLGGRWLHVRADQGRKLLAEAISEAGGSIELVIGYRTVRPEVPGLLLDSLRP 427 Query: 173 -RWQAREVTMVVVTSGEMLQQLWSLIPQWYREH----WLLHCRLLVVSERLAKLARELGW 227 + SG + + + +L +++ + A L Sbjct: 428 VADGGEGYDAICFASGRTARHFLETTGERFGADAARGFLEQAKIVAIGPVTADALAALDL 487 Query: 228 QDIKVADNADNDALLRALQ 246 + VAD + ++ A++ Sbjct: 488 RVDAVADTPSDAGMVEAVK 506 Score = 63.3 bits (153), Expect = 6e-09, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 45/136 (33%), Gaps = 5/136 (3%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + + G+R ++ R + L GA+ C + A E Sbjct: 237 LAWLERRPLFGRRVVVTRAARQSGGLLHALAGAGADAVAFPCLEVAAPEPAEREALDAAL 296 Query: 176 A----REVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDI 230 A + V+V+S L+ + + + L + A + G + Sbjct: 297 APDRLAGLEGVIVSSPNGADALFDALARLNLDARAFAGKLLAAIGTGTAARCQAKGLRPD 356 Query: 231 KVADNADNDALLRALQ 246 + A ++ L+ L+ Sbjct: 357 LIPAKARSEGLIELLR 372 >UniRef50_Q0W5T0 Uroporphyrinogen-III synthase n=1 Tax=uncultured methanogenic archaeon RC-I RepID=Q0W5T0_UNCMA Length = 256 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 85/253 (33%), Gaps = 12/253 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALG--ESDLLFAL 59 I VTRP + V L+ G A P++E P L L E+D + Sbjct: 3 RIAVTRPRKFLPDTVRILKEKGLEAVPVPMMEMIPRNDGA-LEAFFKRLEAGEADTVIIT 61 Query: 60 SQHAVAFAQSQLHQQDR--KWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 SQ+ V F + K + IG T L + P SE L+Q Sbjct: 62 SQNGVQFIYDKAPDPAALTKQLNSVEVIGIGPRTNSVLTERGITHLQMP-GTFSSEGLVQ 120 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-YDGAEEAMRWQA 176 + GKR +LR N G ++ L A GA+V Y + + A Sbjct: 121 DFC-AKLKGKRVEVLRSNHGNPILISGLEAGGAKVREIIVYDIVPLKGEEQAAFVREALE 179 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLH----CRLLVVSERLAKLARELGWQDIKV 232 + TS + L + L ++ V+ A ++ G + V Sbjct: 180 GRIDAYTFTSTMTARSLLMMGESMGVLDPLKREINSKKVAVIGHPTADFLKKSGIRVDAV 239 Query: 233 ADNADNDALLRAL 245 + + ++ AL Sbjct: 240 PERFTFEDMVEAL 252 Score = 56.4 bits (135), Expect = 9e-07, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 39/119 (32%), Gaps = 2/119 (1%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI-HYDGAEEAMRWQAREVTMVVVT 185 KR + R L +G E + R +A E V++T Sbjct: 2 KRIAVTRPRKFLPDTVRILKEKGLEAVPVPMMEMIPRNDGALEAFFKRLEAGEADTVIIT 61 Query: 186 SGEMLQQLWSLIPQ-WYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 S +Q ++ P L ++ + R + E G +++ ++ L++ Sbjct: 62 SQNGVQFIYDKAPDPAALTKQLNSVEVIGIGPRTNSVLTERGITHLQMPGTFSSEGLVQ 120 >UniRef50_C0QQD7 Uroporphyrinogen-III synthase n=1 Tax=Persephonella marina EX-H1 RepID=C0QQD7_PERMH Length = 233 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 96/246 (39%), Gaps = 19/246 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++IL+T+ ++ + ++ + FP I+ P + D D+ S Sbjct: 2 INILITKSEKELKK-IEAVKNIRIDIIPFPAIKTIPLDFDIKTED-------FDIFVFTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + ++ + + A+G T L + + I PQ + SE LL+L Sbjct: 54 VNAVKYFFEKIEPERLE---GKQIIAVGDKTKAELEKIGFKNIKTPQI-QSSEGLLELLS 109 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCA-IHYDGAEEAMRWQAREV 179 +N K+ + R G +L+ L VT Y+ I + + ++ + V Sbjct: 110 NRNYKDKKIALPRAKKGIDLLIKNLD----NVTLIPVYETVLNIPENVDKVKEMFEKKLV 165 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V TS ++ + + +L +++ + + K + LG + V + + Sbjct: 166 DFAVFTSPSNVENFLKIFEK--GLDYLKQTKVVPIGKTTGKKLKSLGIEPFFVPEKPSIE 223 Query: 240 ALLRAL 245 +++ + Sbjct: 224 NIIKEI 229 Score = 55.2 bits (132), Expect = 2e-06, Method: Composition-based stats. Identities = 16/118 (13%), Positives = 43/118 (36%), Gaps = 12/118 (10%) Query: 129 ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGE 188 LI + + I + + ++ + + +D + + + V TS Sbjct: 4 ILITKSEKELKKI-EAVKNIRIDIIPFPAIKTIPLDFD-------IKTEDFDIFVFTSVN 55 Query: 189 MLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 ++ + I L +++ V ++ ++G+++IK ++ LL L Sbjct: 56 AVKYFFEKIE----PERLEGKQIIAVGDKTKAELEKIGFKNIKTPQIQSSEGLLELLS 109 >UniRef50_C5V9U0 Uroporphyrinogen-III synthase n=2 Tax=Corynebacterium matruchotii RepID=C5V9U0_9CORY Length = 260 Score = 170 bits (431), Expect = 4e-41, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 80/239 (33%), Gaps = 14/239 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 + V R L++RL T G P I P L QL L G + + Sbjct: 9 KVAVLRSPEQSHSLITRLETYGAEVISIPTIRIVPPVDLTQLHHAARQLRAGTYEWVVFT 68 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ-DREISEVLLQL 118 S +AV ++ +GR TA +L P R+ + L++ Sbjct: 69 SANAVRCIAERMTG---PLNSQTRVATVGRATARVARHYHLDPVLQPPITRQNALGLVEA 125 Query: 119 PELQNIAG---KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 E N ++ L+ N + D L ++G V Y+ Sbjct: 126 FEPANSRSEERRKILVPHANIAPSTLVDGLKSQGWIVDDIIGYRTILADPPPPNIHDLLV 185 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++T + +TSG ++ L ++ + + + L + ++LG V + Sbjct: 186 TGQITAICITSGSTIRNLITIAGRPHPQTLL-----ACIGPSAEAATKKLGLNVAVVPE 239 Score = 55.2 bits (132), Expect = 2e-06, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 39/128 (30%), Gaps = 8/128 (6%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE--EAMRWQAREVT 180 + G + +LR + L GAEV + A + +A Sbjct: 4 PLHGWKVAVLRSPEQSHSLITRLETYGAEVISIPTIRIVPPVDLTQLHHAARQLRAGTYE 63 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD--NADN 238 VV TS ++ + + R+ V A++AR + + Sbjct: 64 WVVFTSANAVRCIAERM----TGPLNSQTRVATVGRATARVARHYHLDPVLQPPITRQNA 119 Query: 239 DALLRALQ 246 L+ A + Sbjct: 120 LGLVEAFE 127 >UniRef50_B3PF71 Uroporphyrinogen-III synthase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PF71_CELJU Length = 277 Score = 170 bits (431), Expect = 4e-41, Method: Composition-based stats. Identities = 74/255 (29%), Positives = 111/255 (43%), Gaps = 14/255 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDL---LFAL 59 I++TRP E +L+ G L+E P + + + + DL + Sbjct: 8 IIITRPQAQAEPWAKQLQAQGFATRLLTLLEIMPLKDETRQRAIQNRVMDFDLYQKAIFV 67 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYP---QDREISEVLL 116 SQ+AV A L + + P +YFA+G TTA L SE LL Sbjct: 68 SQNAVHQAMDWLDRYWPQLPIGIEYFAVGATTARELAVHGIPVTDLAQAESGSMTSEALL 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ- 175 + LQ +AG++ +I RG GGR +GD L ARGA+V +CE Y+RC + Sbjct: 128 EAASLQQVAGEKVIIFRGLGGRGHMGDVLRARGAQVDYCELYERCLPSHAATGLHQLLAD 187 Query: 176 ----AREVTMVVVTSGEMLQQLWSLIPQWYREH---WLLHCRLLVVSERLAKLARELGWQ 228 ++ + SGE LQ L L+ L LLV SER+ A+ G+ Sbjct: 188 ITCWQARQQVMALHSGESLQHLLQLLELPLLSPLRGRLQRAWLLVPSERIRDQAQTAGFH 247 Query: 229 DIKVADNADNDALLR 243 +A+NA + A+ + Sbjct: 248 RCLLAENATDAAMTQ 262 >UniRef50_C1SL66 Uroporphyrinogen-III synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SL66_9BACT Length = 227 Score = 170 bits (430), Expect = 5e-41, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 96/246 (39%), Gaps = 22/246 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++LVTR + L +++ G + P+IE SP + GE D S Sbjct: 1 MNVLVTREEEKYQILAEKMKAFGLTPFSLPMIECSPVGAIIT--------GEYDYAVFTS 52 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++ + + + + A+G +TA AL + + + P + +E + +L Sbjct: 53 LNSAKYFKPHISRVTIN-----KVVAVGPSTAAALLDIDIKTDIMP-ETFSAEGMKELFA 106 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +++ GK+ L + L RGAE YQ + Y + ++ Sbjct: 107 TEDVEGKKFLFAGAKVRAGDFHEYLRGRGAEPVMVATYQTQPVKYPPGYIEAFLKENKID 166 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V S + + + I ++ ++ + + A R LG+ + D+ D Sbjct: 167 IVTFASPSAARAMLADIQHIDQQ-------IVCIGKTTADEVRFLGYDS-RYPDDYTLDW 218 Query: 241 LLRALQ 246 ++R ++ Sbjct: 219 MVRLIK 224 >UniRef50_A1T0Q9 Uroporphyrinogen-III synthase n=2 Tax=Psychromonas RepID=A1T0Q9_PSYIN Length = 244 Score = 169 bits (429), Expect = 6e-41, Method: Composition-based stats. Identities = 82/242 (33%), Positives = 122/242 (50%), Gaps = 6/242 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR +P + LV+ L G VA+ PL+ + + LA D + A+S Sbjct: 5 RLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLA--KNYDYIIAVSP 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + Q L WP+ +Y A+G T L + Q ++ P+ SE LL LP L Sbjct: 63 NAVDYTQKALA--GINWPQ-TEYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLL 119 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 N+ GK LILRG GGREL+ DTL RGA V + + YQR AI G WQ + + Sbjct: 120 LNLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNING 179 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +++S E+L++L S++P WL + SER+ A+ GW + KV + + Sbjct: 180 AIISSIELLERLMSVVP-LAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQV 238 Query: 242 LR 243 + Sbjct: 239 ID 240 >UniRef50_A5UND1 Uroporphyrinogen III synthase, HemD n=2 Tax=Methanobrevibacter smithii RepID=A5UND1_METS3 Length = 257 Score = 169 bits (428), Expect = 9e-41, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 80/247 (32%), Gaps = 9/247 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 + +TRP+ + + LG P ++ P L + +A D + S Sbjct: 6 VAITRPADRSKAACKIVEELGGQYVLAPTLDLKPV-NSESLKNLIANKDLLDWIVFTSPT 64 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 + L D IG T + L P+D +E LL+ E + Sbjct: 65 TITSLN--LFYPDFLKNLDCKVAVIGNKTGKIAGEQGVKVDLIPED-FTAEGLLEEFEKR 121 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMRWQAREVT 180 NI + I R R ++ + L +V E Y+ + + + + E+ Sbjct: 122 NITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSLFPMDEDKINDLIAKIENNEID 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRL--LVVSERLAKLARELGWQDIKVADNADN 238 + TS + + + + LL L + + K+ + I D Sbjct: 182 AITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIY-PDTYTV 240 Query: 239 DALLRAL 245 ++ L Sbjct: 241 RDMMELL 247 >UniRef50_Q3SFT6 Uroporphyrinogen-III synthase n=1 Tax=Thiobacillus denitrificans ATCC 25259 RepID=Q3SFT6_THIDA Length = 252 Score = 168 bits (427), Expect = 1e-40, Method: Composition-based stats. Identities = 83/244 (34%), Positives = 117/244 (47%), Gaps = 8/244 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR L + +R G A+ FP + F + +L LA + +D + +S Sbjct: 9 TILVTRAPRQAAALSAAIRAAGGSAFEFPALAFEAVP-VDRLQASLAQVVAADFVIFVSP 67 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A F + + A+G TA AL ++ P D + SE LL LP+L Sbjct: 68 NAAEFGMAAIGS----LAAGRSVLAVGPGTARALAAQGLDAVITP-DGQDSEALLALPQL 122 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 ++ GKR +I+RG GGR L+GDTL ARGAEV + ECY+R A D A RWQA + Sbjct: 123 LDVDGKRVVIVRGIGGRALLGDTLAARGAEVHYMECYRRLAPTADAAPLIARWQAGGIDA 182 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V V S E L L +L+ + L H L E++A AR G A + L Sbjct: 183 VTVASAETLHNLAALLGEAGAP-LLAHTPLFAPYEKIAAAARSFGVAQ-ATATPGGDAGL 240 Query: 242 LRAL 245 + L Sbjct: 241 VAGL 244 >UniRef50_A1AXB3 Uroporphyrinogen III synthase HEM4 n=2 Tax=sulfur-oxidizing symbionts RepID=A1AXB3_RUTMC Length = 248 Score = 168 bits (427), Expect = 1e-40, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 105/247 (42%), Gaps = 14/247 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++L+TRP EEL S + G FP ++ + D D++ +S Sbjct: 1 MNVLLTRPLLQVEELQSMVTKSGNKPLLFPTLKLNSI-------DAKVENNYYDVIIFIS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV + L FA+G TA L + +P+ + SE LL L Sbjct: 54 VNAVEYGLKILKTI-----SYHKIFAVGSATARKLSENDIEIDDFPRKKASSEALLALDS 108 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG--AEEAMRWQARE 178 + + K LI RG GRE++ L + +V + E Y+R + + + +R Sbjct: 109 VAQLYHKTILIFRGQSGREVLKQGLIKQNNQVEYVEVYERVNHNINSLHRQSLDELLSRN 168 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++ +TS + ++ L + Q L + L+V+S+R+ +G+ + V N N Sbjct: 169 EGVISITSIDSMKLLVKISSQILDVDRLKNYLLVVLSDRIKTYVNSIGFNKVLVTPNTSN 228 Query: 239 DALLRAL 245 + ++ L Sbjct: 229 NGIISVL 235 >UniRef50_Q3ACT2 Uroporphyrinogen-III synthase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=Q3ACT2_CARHZ Length = 343 Score = 168 bits (426), Expect = 1e-40, Method: Composition-based stats. Identities = 36/246 (14%), Positives = 70/246 (28%), Gaps = 11/246 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L+ R + R +G PL++ + L D L S Sbjct: 102 RVLIPRTEADEKRECGRFGAIGIEV---PLLKITYIPDERILQ---LDFSAYDWLIFTSA 155 Query: 62 HAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 H V L+ + +G TA AL PQ ++ L Sbjct: 156 HGVEGFFFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFSPQK-FTAKDLALELT 214 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + K ++++GN GR + + L Y+ +A+ + Sbjct: 215 TSGMIQKGVIVIQGNLGRPELLEILARNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLID 274 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TS + I L H + + + + + + Sbjct: 275 VLFFTSPSTFNNFYQFISDENLAKNLPH---FAIGPTTYEAFLQKDIRRKYFSSEHTLEG 331 Query: 241 LLRALQ 246 L + L+ Sbjct: 332 LWQTLK 337 Score = 57.2 bits (137), Expect = 5e-07, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 44/134 (32%), Gaps = 12/134 (8%) Query: 115 LLQLPELQNIAGKRALILR--GNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM 172 L +AG R LI R + RE A G EV I Y E + Sbjct: 89 LQHFLNNGPLAGVRVLIPRTEADEKRE--CGRFGAIGIEVPLL------KITYIPDERIL 140 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV 232 + ++ TS ++ + + + ++ VV E+ AK ++ G Sbjct: 141 QLDFSAYDWLIFTSAHGVEGFFFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFS 200 Query: 233 ADNADNDALLRALQ 246 L AL+ Sbjct: 201 PQKFTAKDL--ALE 212 >UniRef50_A8PKZ2 Uroporphyrinogen-III synthase n=1 Tax=Rickettsiella grylli RepID=A8PKZ2_9COXI Length = 262 Score = 168 bits (426), Expect = 2e-40, Method: Composition-based stats. Identities = 68/246 (27%), Positives = 116/246 (47%), Gaps = 5/246 (2%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP EL ++++ G HFP +E + + ++ +L L + +S Sbjct: 7 LRVLITRPLHQTSELTTQIQNCGGFVVHFPTLEINQVPNIKKINSELKKLNHYHFVIFIS 66 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++V +H WP A G T AL +P+ ++ L Sbjct: 67 PNSVFNTAPSIHAIWPHWPCSTKTIATGLGTVSALKQHHLPSHFHPEKNYTGMGIINLSI 126 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 LQ I GK+ LI++G GGR + L RGA V Y+R + ++ Sbjct: 127 LQTIKGKKILIIKGQGGRLNLIKNLKTRGASVNNLVVYKRQLPAIEKQCIPN---QEDID 183 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW-QDIKVADNADND 239 +++ TSG L+ L +L+ + H L ++LV+S RLA +A++LG+ + +ADNA +D Sbjct: 184 VIICTSGTGLKNLVTLLHPRWESH-LFKKQMLVISPRLAVIAKKLGFVKLPLIADNASHD 242 Query: 240 ALLRAL 245 A+L L Sbjct: 243 AILHTL 248 >UniRef50_Q1QSV6 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QSV6_CHRSD Length = 251 Score = 168 bits (426), Expect = 2e-40, Method: Composition-based stats. Identities = 79/247 (31%), Positives = 114/247 (46%), Gaps = 8/247 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+VTRP G LV L T G A H L+ P + D++ S Sbjct: 6 RIVVTRPGEGGRRLVDALSTAGFEAVHPALMTLQPLAADEVERGAVLDFDLYDVVVVTSP 65 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQ--DREISEVLLQLP 119 A + + + P+ P ++A+G +TA LH G K P SE LL + Sbjct: 66 FAAECLDEWIDRYWPQLPQGPRFYAVGASTAATLHRTLGIKAKVPDPARGTTSEALLAMR 125 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 L + G+RALI+ G+GGR+++ + L ARGA V Y+R D + Sbjct: 126 SLTRLDGQRALIVGGSGGRQVMAEALEARGARVAKLALYRRVYTAPDEVTV-DWLASGAF 184 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 T ++VTSGE+L+ L S Q + L+V S+RLA LA +G+ VA A D Sbjct: 185 TAMIVTSGELLEHLVSWCGQAAL-----NKPLIVSSQRLATLADTMGFASPHVASGATPD 239 Query: 240 ALLRALQ 246 AL+ A+Q Sbjct: 240 ALVTAVQ 246 >UniRef50_A8UZZ5 Uroporphyrinogen-III synthetase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8UZZ5_9AQUI Length = 228 Score = 167 bits (424), Expect = 2e-40, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 84/245 (34%), Gaps = 20/245 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +IL+TR +L + + PLI+ + + P L + D L S+ Sbjct: 3 NILITREEKLDNKLEKIAKEKDLNIIYCPLIKTTKIEFNPP------DLDKYDYLIITSK 56 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + L + A+G T L + +I+ P + + + +L + Sbjct: 57 NAVKYF---LKSIPLEKILHKKVIAVGEKTKKYLKNLGFDEIIIP-EINSARGIEKLIQE 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI-HYDGAEEAMRWQAREVT 180 + K+ L +R G+E+ + Y+ + E + E+ Sbjct: 113 KQFKDKKFLFIRAEKGQEI-------NNKNLDLLIVYKTIFNKPENYKECSKLLIKGEID 165 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V+ +S + E L + +++ + K G+ V + Sbjct: 166 YVIFSSPSTFYSFMENFKNY--EKLLNNTKIITIGNTTKKAVESKGFNVYFVPKKPSFEE 223 Query: 241 LLRAL 245 ++ AL Sbjct: 224 IINAL 228 Score = 56.0 bits (134), Expect = 1e-06, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 46/120 (38%), Gaps = 10/120 (8%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTS 186 K LI R + + + +C + I ++ + + +++TS Sbjct: 2 KNILITREEKLDNKLEKIAKEKDLNIIYCPLIKTTKIEFNPPDL------DKYDYLIITS 55 Query: 187 GEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 ++ IP +LH +++ V E+ K + LG+ +I + + + + +Q Sbjct: 56 KNAVKYFLKSIPLEK----ILHKKVIAVGEKTKKYLKNLGFDEIIIPEINSARGIEKLIQ 111 >UniRef50_C2C1P1 Uroporphyrinogen-III synthase n=1 Tax=Listeria grayi DSM 20601 RepID=C2C1P1_LISGR Length = 242 Score = 167 bits (424), Expect = 2e-40, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 80/245 (32%), Gaps = 16/245 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 + ++TR + E+ + LG A PLIE + E D +F S Sbjct: 6 TFVLTRTAADNEKWLPYFHELGVEAVSLPLIETKALPFQIE--------KEYDWIFFTSA 57 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ + + IG TA AL + P ++E L+ Sbjct: 58 KAIHYFAEKYDLAVVTA----KIAVIGEKTAEALIRYGRKADFEPS-SYVAETFLEEWLP 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q A KR L R + RE+I TL +G V + Y+ A Q + + Sbjct: 113 QYSADKRILFPRSSLAREVIAKTLREQGYSVEEIDIYETVIPASSSNLFAALIQTEKDFL 172 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV-ADNADNDA 240 + S ++ + + + ++ G AD +A Sbjct: 173 FLFASPSAWHNFEAICQTRNQS--VQAWEYGSIGPITSRAIEASGCSVKYQPADTYTMEA 230 Query: 241 LLRAL 245 +++ + Sbjct: 231 MIQEI 235 Score = 56.4 bits (135), Expect = 1e-06, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 39/125 (31%), Gaps = 1/125 (0%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL R S A E + LR G + E L L + L S Sbjct: 119 RILFPRSSLAREVIAKTLREQGYSVEEIDIYETVIPASSSNLFAALIQTEKDFLFLFASP 178 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A ++ +++ +Y +IG T+ A+ P D E ++Q Sbjct: 179 SAWHNFEAICQTRNQSVQAW-EYGSIGPITSRAIEASGCSVKYQPADTYTMEAMIQEIMR 237 Query: 122 QNIAG 126 + Sbjct: 238 EEKQS 242 >UniRef50_Q31JG4 Uroporphyrinogen-III synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31JG4_THICR Length = 264 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 62/255 (24%), Positives = 109/255 (42%), Gaps = 13/255 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ L TRP E L +R G P ++ P L D +F +S Sbjct: 8 LTFLNTRPVEQAEALSQSVREKGHQVLACPTLKICPRSLPQ---QAGVTLSTFDKVFFIS 64 Query: 61 QHAVAFAQSQLH---QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 Q+AV Q + + FAIG++T A+ + ++ ++E LLQ Sbjct: 65 QNAVKQFVDMWQSAYQTHPVFAEKTECFAIGQSTYNAMKALDWPVAKVHSNQYVTEALLQ 124 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LQN+ ++ LI++G GGR + + L A GA VT Y+R + A+ + AR Sbjct: 125 SEVLQNLTDQQCLIVKGKGGRPTLAEGLIAAGATVTEWAVYERVPADFCDAQWQVFRSAR 184 Query: 178 EVTMVVVTSGEMLQQLWSLI-----PQWYREHWLLHCRLLVVSERLAKLARELGWQ-DIK 231 +++++S + L ++ + WL ++V S+R+ ++ WQ + Sbjct: 185 HP-VLLISSLDAWYGLEKMLKNSGYGSKNDQAWLFLQDVIVFSDRIKHALQQQEWQGRLF 243 Query: 232 VADNADNDALLRALQ 246 V N +L AL+ Sbjct: 244 VVPQQSNAGILTALE 258 >UniRef50_Q3IBM6 Uroporphyrinogen III synthase/methyltransferase n=1 Tax=uncultured sulfate-reducing bacterium RepID=Q3IBM6_9BACT Length = 518 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 84/246 (34%), Gaps = 3/246 (1%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++VTRP+ L LR LG +P + + + + S+ Sbjct: 261 RVMVTRPADQSVALYGDLRELGAEVLAYPTLATVEDFRSDDWDALRRIQEKERWVVFTSE 320 Query: 62 HAVAFAQSQLHQQ--DRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + Q D + A G TA +L+ + P ++ + Q+ Sbjct: 321 NGVRYFLEQWFATIGDIRGLNDYRIAAAGDGTARSLNANNLAPDFVPTRASMAALAQQMA 380 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E ++ + +RGN + I L GA+V Y+ + A + A Sbjct: 381 EKVPMSKATVVRVRGNARNDPIERALRETGAQVVSLPVYRTFPTKWRSA-VKEKLFAYPP 439 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++ TSG + L + + + ++ + ++ R G + Sbjct: 440 DVILFTSGTAVDGLAANLSARELKELSSGAAVVSIGPATSRTIRTHGITVELESKVHTMP 499 Query: 240 ALLRAL 245 +LL L Sbjct: 500 SLLEEL 505 Score = 55.6 bits (133), Expect = 1e-06, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 38/129 (29%), Gaps = 1/129 (0%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L+ + + + G R ++ R + L GAEV +A+R Sbjct: 249 LKWFQDRPLFGVRVMVTRPADQSVALYGDLRELGAEVLAYPTLATVEDFRSDDWDALRRI 308 Query: 176 AREVTMVVVTSGEMLQQLWSL-IPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + VV TS ++ L R+ + A+ V Sbjct: 309 QEKERWVVFTSENGVRYFLEQWFATIGDIRGLNDYRIAAAGDGTARSLNANNLAPDFVPT 368 Query: 235 NADNDALLR 243 A AL + Sbjct: 369 RASMAALAQ 377 >UniRef50_B8DHJ3 Uroporphyrinogen-III synthase n=18 Tax=Listeria RepID=B8DHJ3_LISMH Length = 240 Score = 167 bits (423), Expect = 3e-40, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 79/244 (32%), Gaps = 13/244 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++TR + + + G PLI+ P + E++ LF S Sbjct: 4 KVVLTREASKNQPWQTYFGQNGFAVVSVPLIKTRPKK-----ISLSREQLEAEWLFLTSA 58 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV + ++ IG T L + P SE+ L+ Sbjct: 59 NAVEYFF-----MNQPGEAHYKIAVIGEKTREKLAEFGYKPSFVPSI-YQSEIFLEEWLN 112 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +N L+ + N R +I DTLT +G V E Y+ + + + ++ + Sbjct: 113 ENPEKTSVLLPQSNLSRSIIKDTLTEKGYLVHSVELYETVSPENSKIKLTELLNSNDIHI 172 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 ++ S + +S+ + + + + GW+ L Sbjct: 173 IIFASPSAWKNFYSIAKSLPVQK--EKWHIASIGSITTEAILADGWEVKYQPKTFTMKHL 230 Query: 242 LRAL 245 + Sbjct: 231 ADLI 234 >UniRef50_A4G3V3 Uroporphyrinogen III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=2 Tax=Oxalobacteraceae RepID=A4G3V3_HERAR Length = 260 Score = 166 bits (422), Expect = 5e-40, Method: Composition-based stats. Identities = 74/255 (29%), Positives = 111/255 (43%), Gaps = 17/255 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TRP E L R+ LG+ A FPL++ P L L L L+ +S + Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILPLADQASLQQALRDLSGYALIAFVSPN 68 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQ----KILYPQ--DREISEVLL 116 A WPR +G + LAL I+ P DR SE LL Sbjct: 69 A----IDAALAARADWPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTDSETLL 124 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMR--W 174 +L + K+ LI+RG GR L+ + L A GA+VT Y+R A +D Sbjct: 125 AELDLPALRNKQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDATRRRELKRL 184 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLARELGWQDIK 231 + +V TS E L+ L ++ Q + R++V R+ + A+ LG+ +I Sbjct: 185 LHGQNDWIV-TSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRIGETAQLLGFSNIT 243 Query: 232 VADNADNDALLRALQ 246 V + +D LL ALQ Sbjct: 244 VTRS-GDDGLLAALQ 257 >UniRef50_A8MGE5 Uroporphyrin-III C-methyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MGE5_ALKOO Length = 496 Score = 165 bits (419), Expect = 9e-40, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 80/249 (32%), Gaps = 22/249 (8%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+TRP +L L LG +P I S + + S Sbjct: 260 KILITRPKQTIGKLSQMLWELGAETVEYPCIRTSTIDFD-------LNMNHLQWIVFTSA 312 Query: 62 HAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL-QL 118 V +L + D + +G TA L + P +E L +L Sbjct: 313 VGVKAFFDKLFTMKMDSRCLHDKKIAVVGSETAAELLKYGIRADFIPS-VFDAEHLATEL 371 Query: 119 PELQNIAGK-RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 I K + + R G E + LT EV+ Y+ + + Sbjct: 372 LNSGQITSKDQVGVFRAKTGSEDLVRILTDHNVEVSDVAVYETNYVKN------HKIDVN 425 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + V TS +Q + + + + ++ A +A++ G + ++D A Sbjct: 426 KFDYVAFTSASCVQGFVESFGE---DADFSSVNAVCIGKQTASMAKQYGM-NTTISDIAT 481 Query: 238 NDALLRALQ 246 ++ ++ Sbjct: 482 ISGIVDKIK 490 Score = 63.3 bits (153), Expect = 7e-09, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 39/130 (30%), Gaps = 8/130 (6%) Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + G + LI R + L GAE C + I +D Sbjct: 249 DWFSNLPLKGCKILITRPKQTIGKLSQMLWELGAETVEYPCIRTSTIDFD-------LNM 301 Query: 177 REVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + +V TS ++ + L L ++ VV A + G + + Sbjct: 302 NHLQWIVFTSAVGVKAFFDKLFTMKMDSRCLHDKKIAVVGSETAAELLKYGIRADFIPSV 361 Query: 236 ADNDALLRAL 245 D + L L Sbjct: 362 FDAEHLATEL 371 >UniRef50_C1D9V4 HemD n=1 Tax=Laribacter hongkongensis HLHK9 RepID=C1D9V4_LARHH Length = 248 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 71/243 (29%), Positives = 105/243 (43%), Gaps = 8/243 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TRP AG L + LRT G + +PL+ P + L AAL +D L +S Sbjct: 6 VIITRPHEAGAPLAAALRTAGFAPFEWPLLALEP--EPEALDRLPAALAGADWLVVVSPS 63 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A L + P A+GR TA L SG+ +LYP SE LL LP+ Sbjct: 64 AARLIAPALA----RLPAGLRLAAVGRATAQVLEQASGRPVLYPATGNDSEALLALPDWG 119 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + G+ +I +G+GGR + + L RGA V Y+R + D A V Sbjct: 120 ALDGRTVVIAKGHGGRPWLAENLARRGARVVPLALYRRRKLTPDPAALQAALAVHPQAAV 179 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 +VTS E+ + L + R+A+ LG +K A +DA++ Sbjct: 180 LVTSTEIAEAWRQAAGDALWPS-LQSIMHIAPHPRIAERLTALGVMRVKTT-GAGDDAVI 237 Query: 243 RAL 245 AL Sbjct: 238 DAL 240 >UniRef50_C9RPT4 Uroporphyrin-III C-methyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT4_FIBSS Length = 525 Score = 165 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 85/265 (32%), Gaps = 33/265 (12%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPG-----------------QQLPQLA 44 ++VTR + + +RL LG P+IE +LA Sbjct: 263 RLVVTRAAKQSSGITARLTALGAEVIETPMIETRNVLPYCHAELPSCIANSYEYDTAELA 322 Query: 45 DQ--LAALGESDLLFALSQHAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSG 100 D L + D+L S + V QL + D + ++G+ T L Sbjct: 323 DLADFEDLKDFDILAFTSTNGVESFFEQLFTAEYDVRELAGKKIASVGKITEKKLLEYGI 382 Query: 101 QKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 + P+D E L L R L+L+GN + + L T Y+ Sbjct: 383 RCDYVPKD-HTGEGLGLLLREVVDDESRILLLQGNLADDTLLKLLPKA----TRWIVYET 437 Query: 161 CAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAK 220 I + + VV S ++ + L + Sbjct: 438 LPIAELPDWKREAIASA--DAVVFASSSAVENFAQISSLSSFVSRLS----FCIGRMTEA 491 Query: 221 LARELGWQDIKVADNADNDALLRAL 245 A++ G++ + +D D+L++ + Sbjct: 492 SAKKHGFETV-TSDETTMDSLVKKI 515 Score = 68.0 bits (165), Expect = 3e-10, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 49/146 (33%), Gaps = 20/146 (13%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI------------ 163 L + ++GKR ++ R I LTA GAEV + + Sbjct: 251 LAWKKNLPLSGKRLVVTRAAKQSSGITARLTALGAEVIETPMIETRNVLPYCHAELPSCI 310 Query: 164 ----HYDGAEEAMRW---QAREVTMVVVTSGEMLQQLWS-LIPQWYREHWLLHCRLLVVS 215 YD AE A ++ ++ TS ++ + L Y L ++ V Sbjct: 311 ANSYEYDTAELADLADFEDLKDFDILAFTSTNGVESFFEQLFTAEYDVRELAGKKIASVG 370 Query: 216 ERLAKLARELGWQDIKVADNADNDAL 241 + K E G + V + + L Sbjct: 371 KITEKKLLEYGIRCDYVPKDHTGEGL 396 >UniRef50_A0Z3B7 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z3B7_9GAMM Length = 660 Score = 165 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 73/246 (29%), Positives = 117/246 (47%), Gaps = 8/246 (3%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++ ++TRP E L L G + PLI + +L L D+ +S Sbjct: 3 LTAVLTRPGGVVEPLQLVLEQRGVDTFVQPLINI---ASISVEHRELITLYPGDICIFIS 59 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV S L Q R+ A+GR TA A+ + + SE LL L Sbjct: 60 VNAVEQGLSNLAPQLREL--GCPILAVGRATASAISAAGF--DVSVPSQADSEGLLGLDI 115 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L + GK+ +I++G GGR L+ + L RGA+V CY+R D + + RE Sbjct: 116 LHGVKGKQVVIVKGEGGRGLLAEALRERGADVVSYVCYRRDPTGIDAGQFCWQLCEREHV 175 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + +SGE+++QL L+ Q + + L ++V S R+AK+A LGW ++ A A +D+ Sbjct: 176 VFQASSGEIVEQLTELLGQGGQPNLLDS-PVIVPSGRVAKIAVGLGWTNVITAAGAGDDS 234 Query: 241 LLRALQ 246 L A++ Sbjct: 235 FLSAIE 240 >UniRef50_A7NKU9 Uroporphyrinogen III synthase HEM4 n=2 Tax=Roseiflexus RepID=A7NKU9_ROSCS Length = 269 Score = 163 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 58/249 (23%), Positives = 96/249 (38%), Gaps = 12/249 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I VTR + E L + L + G P I ++P +L L L + D + S Sbjct: 11 RIAVTRAAERAEGLAAALSSEGAEVLVCPTIAYAPPDDPDRLEAALERLDQYDWIIFTSV 70 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV Q P A+G+ TA A+ + G+ L P ++ +E LL EL Sbjct: 71 AAVDTLARY---QALPPPLHVRVAAVGKATAAAIESRGGRVDLLPA-QQNAEGLLA--EL 124 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +N+AG+R L+ + R+ + L R A V Y+ + R + Sbjct: 125 RNVAGQRFLLPVSDIARDTLAVGLREREALVDVVTAYRTV-PGPGVRDLIDPLCRRAIDA 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLH-----CRLLVVSERLAKLARELGWQDIKVADNA 236 VV +S L+ L + Q+ + L+ + A+ R+ G A N Sbjct: 184 VVFSSPSTLRYLIDGMEQFGIARSVARALFDGVALIAIGPTTAQALRDEGLSVAAQAPNP 243 Query: 237 DNDALLRAL 245 + + A+ Sbjct: 244 AVEGVAEAV 252 Score = 50.2 bits (119), Expect = 5e-05, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 43/129 (33%), Gaps = 4/129 (3%) Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + + GKR + R E + L++ GAEV C EA + Sbjct: 1 MDTTGQLQGKRIAVTRAAERAEGLAAALSSEGAEVLVCPTIAYAPPDDPDRLEAALERLD 60 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + ++ TS + L LH R+ V + A G + + + Sbjct: 61 QYDWIIFTSVAAVDTLARYQALPPP----LHVRVAAVGKATAAAIESRGGRVDLLPAQQN 116 Query: 238 NDALLRALQ 246 + LL L+ Sbjct: 117 AEGLLAELR 125 >UniRef50_UPI0001B5826B putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Streptomyces sp. C RepID=UPI0001B5826B Length = 542 Score = 163 bits (414), Expect = 4e-39, Method: Composition-based stats. Identities = 39/198 (19%), Positives = 66/198 (33%), Gaps = 7/198 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R L +LR+ G V P I P + Q+ + L G + + Sbjct: 282 RVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFT 341 Query: 60 SQHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV + + + A+G TA AL + L P + + LL+ Sbjct: 342 SVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAALVEFGVKPDLVPSGEQSAAGLLE 401 Query: 118 LPELQNI---AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + R + R + E + L G EV Y+ A+ Sbjct: 402 DWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPADTREAI 461 Query: 175 QAREVTMVVVTSGEMLQQ 192 + V+ TS ++ Sbjct: 462 KGGGFDAVLFTSSSTVRN 479 Score = 64.5 bits (156), Expect = 3e-09, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 36/132 (27%), Gaps = 4/132 (3%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGAEEAMR 173 L E + + G R L+ R + D L + GA Sbjct: 270 LAWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKG 329 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKV 232 + TS ++ + ++ + ++ V E+ A E G + V Sbjct: 330 LVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAALVEFGVKPDLV 389 Query: 233 AD-NADNDALLR 243 LL Sbjct: 390 PSGEQSAAGLLE 401 >UniRef50_A5CNI5 HemD protein n=4 Tax=Actinobacteria (class) RepID=A5CNI5_CLAM3 Length = 279 Score = 163 bits (413), Expect = 5e-39, Method: Composition-based stats. Identities = 61/248 (24%), Positives = 88/248 (35%), Gaps = 14/248 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 +LV R P G+ + LR G P+I F+ Q L LA L G D L Sbjct: 13 RVLVPRGGPWGDGVAYDLRAQGATPVVAPMINFAATQDAQALESALADLAAGSFDWLTVT 72 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL- 118 S V L P A+G TTA AL P + LL+ Sbjct: 73 SATTVDV----LASHRAVVPEGTRIAAVGETTAAALVAAGYTVDFVPSIDSSATALLEEW 128 Query: 119 -PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 +R L LR + + D L ARG +V Y+ + + Sbjct: 129 TEMAAGSPRRRVLTLRSEIAKPTLTDGLIARGHDVRSVVAYRTVGV-LVSDRIREDVSSG 187 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 V ++VTSG + +Q+ + + + R AK AR G + VA Sbjct: 188 RVRAILVTSGSVAEQVHEQLGDVPD-----GVLIACIGPRTAKDARRSGVRVDVVASERS 242 Query: 238 NDALLRAL 245 +L++AL Sbjct: 243 AASLIQAL 250 Score = 51.8 bits (123), Expect = 2e-05, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 34/127 (26%), Gaps = 5/127 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L R A L L G ++ + +++ G + S Sbjct: 139 RVLTLRSEIAKPTLTDGLIARGHDVRSVVAYRTVGVLVSDRIREDVSS-GRVRAILVTSG 197 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 QL P IG TA + + +R + ++ L E+ Sbjct: 198 SVAEQVHEQLG----DVPDGVLIACIGPRTAKDARRSGVRVDVVASERSAASLIQALVEI 253 Query: 122 QNIAGKR 128 R Sbjct: 254 ARHEEPR 260 >UniRef50_Q5QUS2 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina loihiensis RepID=Q5QUS2_IDILO Length = 251 Score = 163 bits (413), Expect = 5e-39, Method: Composition-based stats. Identities = 72/243 (29%), Positives = 111/243 (45%), Gaps = 8/243 (3%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +L+ RP + ++ +LR G+ + IE P + Q+ D + +S++ Sbjct: 9 VLLLRPGKSPDDFTQQLRKTGRECFVHSFIEIEPLPVNKEQLTQIKQ-KHWDGIVIVSKN 67 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A +A Y+A+G TA + P SE LL+L ELQ Sbjct: 68 AAHYASRAGFSGVPS-----KYYAVGPGTASFACKHLNTAVSCPAFIHQSEGLLELSELQ 122 Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + + LI+RG GGREL+ D + ARGA V + E Y+R + + E +W + V + Sbjct: 123 KLQQQNWLIIRGEGGRELLADAIRARGASVDYWEVYRRKQLTLNDPELIQQWIS-SVGTI 181 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 VVTS E L S +P + WL C+ +V S RL L +IKV +A + L+ Sbjct: 182 VVTSAEQLGYFLSSMPNSA-QSWLDSCQWIVPSHRLKGLIPFGQSDNIKVTGSAADAILM 240 Query: 243 RAL 245 AL Sbjct: 241 NAL 243 >UniRef50_B6R6Q3 Uroporphyrinogen-III synthase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R6Q3_9RHOB Length = 236 Score = 163 bits (412), Expect = 7e-39, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 82/247 (33%), Gaps = 16/247 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ILVTRP P ++ +L +G P++ F P +A G++ + S Sbjct: 1 MKILVTRPQPQADKTAQKLVAMGHEVIVEPMLSFQPLTVNGDVA------GDAKAIAVTS 54 Query: 61 QHAVAFA-QSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV + L + +++G TA A KI+ S L Sbjct: 55 AKAVEALVFNGL----VDKLQHLPLYSVGEATAKAAEASGFPKIICADGDVDS---LGRL 107 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + L +G E YQ A + +A + Sbjct: 108 IAERNQDGPVFYPAAVDRSGDLAGQLEQQGIACRMVEVYQMAAATGFSGKTRDLIEAGTL 167 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + S +Q S+ +L + L VS+R+A+ A+ G ++ A D Sbjct: 168 DCALFYSPRTIQIFLSISNLEKTTVFLNSMKALCVSKRVAEQAQSFG--EVFTAKTPSED 225 Query: 240 ALLRALQ 246 L L Sbjct: 226 GLFELLS 232 >UniRef50_UPI0000E105B4 uroporphyrinogen III synthase HEM4 n=1 Tax=Glaciecola sp. HTCC2999 RepID=UPI0000E105B4 Length = 249 Score = 162 bits (411), Expect = 8e-39, Method: Composition-based stats. Identities = 65/254 (25%), Positives = 111/254 (43%), Gaps = 22/254 (8%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 LV RP + G + L P + + L D + S+ A Sbjct: 3 LVLRPEHKIDSSQHAFEQAGIPSIGLALQTILPRDDIAE-QVHLVNFHHVDNVIFTSKMA 61 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDRE---------ISEV 114 FA + +A+G++T L + Q + + + SE Sbjct: 62 AQFALPFM----PDLSSHTYVYAVGKSTFQTLAQWTHQYPFWCNNHQLMMPLAHQQTSEG 117 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 +L LP L ++ +R +I++G GGRE + DTL+ RGA V+ C Y+R ++ + W Sbjct: 118 ILSLPSLSDVTEQRIVIVKGLGGRETLRDTLSERGAVVSECTVYERITLNNPVST--QAW 175 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD--IKV 232 Q ++T + TS E LQ + + P WL + +VVS R+A+ A +LG + I + Sbjct: 176 QVTDITGITATSNEQLQLAFDIYPH----SWLTELKWVVVSPRIAQYALKLGIPNQQISI 231 Query: 233 ADNADNDALLRALQ 246 + +AD+ AL+ + Sbjct: 232 SQSADDAALIAHIN 245 >UniRef50_A0B883 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase n=7 Tax=Archaea RepID=A0B883_METTP Length = 491 Score = 162 bits (411), Expect = 8e-39, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 80/247 (32%), Gaps = 15/247 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I + R + V G + P I + + + + +++ + S Sbjct: 247 RIAILRAEKQLDVSVRLAERYGFIPVAAPSISLRALELPHDIKE---RIEKTECVVFTSS 303 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V + + AIG TA AL + P + S L+ Sbjct: 304 NGVEIISRR--SDLVDLIQKKRVAAIGPKTAQALSERGVNVDVIPAE-YSSRGLVNALGG 360 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 K L+LR G + L + G EV Y+ D + + +A + + Sbjct: 361 F----KSVLLLRSAQGSPALLQGLRSSGIEVEDVPVYE-VKGSEDSRLDDLIRRAELIDV 415 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCR----LLVVSERLAKLARELGWQDIKVADNAD 237 TSG ++ L + E L ++ + A++ E G + + + Sbjct: 416 FAFTSGSTVRYLMRRSEELGMEDHLRRALDSALVVAIGPPTAEVLGEFGVRVDLIPERYT 475 Query: 238 NDALLRA 244 + +L A Sbjct: 476 FEGMLEA 482 Score = 53.3 bits (127), Expect = 7e-06, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 38/132 (28%), Gaps = 20/132 (15%) Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV- 179 + + +R ILR ++ V E Y + ++ Sbjct: 240 ERYLRQRRIAILRAEKQLDV----------SVRLAERYGFIPVAAPSISLRALELPHDIK 289 Query: 180 ------TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 VV TS ++ + + + R+ + + A+ E G + Sbjct: 290 ERIEKTECVVFTSSNGVEI---ISRRSDLVDLIQKKRVAAIGPKTAQALSERGVNVDVIP 346 Query: 234 DNADNDALLRAL 245 + L+ AL Sbjct: 347 AEYSSRGLVNAL 358 >UniRef50_Q0ST17 Uroporphyrinogen-III methyltransferase/synthase n=25 Tax=Clostridium RepID=Q0ST17_CLOPS Length = 492 Score = 162 bits (410), Expect = 1e-38, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 87/246 (35%), Gaps = 14/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I +TR +E+ +L+ LG I+ + L + + L + D + S Sbjct: 252 NICLTRSKEQSKEIKWKLKELGAEVTEINSIKIKETSEN--LDEYINTLEKYDHIVFTSV 309 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAI-GRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV L ++ ++ FA+ G+ T AL + +E L ++ + Sbjct: 310 NAVNVFFDYLVKKRVDIRKIKADFAVLGKATKKALIARGIVPSIM-AHSFTAEGLFEVLK 368 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G+ LI + RE + D L + GA+ Y EV Sbjct: 369 DNIKEGEEVLIPCSSLSREYLFDNLASLGAKCHRVNIYDTICGDVKNPRAFK-----EVD 423 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 MV+ TS ++ + +I L + + K E G + K+ D Sbjct: 424 MVLYTSPSTVKNMIDMIG----LESLKEKVSIAIGPITLKALNESGIEG-KMCKTHCGDG 478 Query: 241 LLRALQ 246 L ++ Sbjct: 479 FLSEIE 484 Score = 64.1 bits (155), Expect = 4e-09, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 35/122 (28%), Gaps = 4/122 (3%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVV 184 G + R + I L GAEVT I + +V Sbjct: 250 GANICLTRSKEQSKEIKWKLKELGAEVTEIN---SIKIKETSENLDEYINTLEKYDHIVF 306 Query: 185 TSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 TS + + + + + + V+ + K G +A + + L Sbjct: 307 TSVNAVNVFFDYLVKKRVDIRKIKADFAVLGKATKKALIARGIVPSIMAHSFTAEGLFEV 366 Query: 245 LQ 246 L+ Sbjct: 367 LK 368 >UniRef50_Q1IWF9 Uroporphyrin-III methyltransferase and synthase domains n=4 Tax=Bacteria RepID=Q1IWF9_DEIGD Length = 507 Score = 161 bits (408), Expect = 2e-38, Method: Composition-based stats. Identities = 52/236 (22%), Positives = 76/236 (32%), Gaps = 16/236 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++ VTR L LR G PLI F+ + L +L L L S Sbjct: 263 TVAVTRTREGASALSELLRARGASVLEVPLIRFAATENAAALQTRLRDLSGVTWLLLTSN 322 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV + L A+G +TA +L + P + +QLP Sbjct: 323 QAVTALFAHLEHLGLDARHLAGVKVAAVGPSTARSLAEQGLRADFVPSTPGARYLGVQLP 382 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G+ AL L + TL ARG E Y+ E R Sbjct: 383 AR---PGEVALHLTSQVAEAELQQTLEARGIRYERAELYRTEPARLSTPELERL---RGA 436 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 +V + SG + L +L + + + A AR G+ + VA Sbjct: 437 DVVTLASGSAARHLAALAG--------TDFTVAAMGPQTADAARAAGFTRVTVARE 484 Score = 64.9 bits (157), Expect = 2e-09, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 52/151 (34%), Gaps = 6/151 (3%) Query: 92 ALALHTVSGQKILYPQDREIS---EVL--LQLPELQNIAGKRALILRGNGGRELIGDTLT 146 A + + E++ E L + +AG+ + R G + + L Sbjct: 222 AQRVREAGLEAPAVTVVGEVARLRETLRWFDVAPAGPLAGRTVAVTRTREGASALSELLR 281 Query: 147 ARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHW- 205 ARGA V + A A + VT +++TS + + L++ + + Sbjct: 282 ARGASVLEVPLIRFAATENAAALQTRLRDLSGVTWLLLTSNQAVTALFAHLEHLGLDARH 341 Query: 206 LLHCRLLVVSERLAKLARELGWQDIKVADNA 236 L ++ V A+ E G + V Sbjct: 342 LAGVKVAAVGPSTARSLAEQGLRADFVPSTP 372 >UniRef50_D2RNT3 Uroporphyrin-III C-methyltransferase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT3_ACIFE Length = 489 Score = 160 bits (405), Expect = 4e-38, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 83/247 (33%), Gaps = 18/247 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVT E+ L ++G+ P++E P + L S+ Sbjct: 253 KILVTGTPVFCGEVARALASVGKTVTELPILELEPL-----FQNIPEDFDRYGWLVFTSR 307 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + V + + RL + IG+ TA L Q L P + +E L +L Sbjct: 308 NGVRLFFRWFRSARQDFRRLGQVRFACIGQGTAEELADQGFQADLMP-EVFTAEDLGRLL 366 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 AG R L+LR G + L G + Y+ E Sbjct: 367 GETLEAGDRCLLLRAEEGSPDLVRELDRAGRKYRDVPLYRIRTRKILTGAETRL----AP 422 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++ SG +++ + R+L + A+ ARE G ++ A Sbjct: 423 QVMIFGSGRGVREFFRRF------TLAPETRVLCIGPVTARAAREAGCSQVETAAIHSAA 476 Query: 240 ALLRALQ 246 + AL+ Sbjct: 477 GIRDALE 483 >UniRef50_A4SWL1 Uroporphyrinogen III synthase HEM4 n=2 Tax=Polynucleobacter necessarius RepID=A4SWL1_POLSQ Length = 274 Score = 160 bits (405), Expect = 4e-38, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 108/265 (40%), Gaps = 24/265 (9%) Query: 2 SILVTRPSPAGEELVSRLRT---LGQVA-------WHFPLIEFSPGQQLPQLADQLAALG 51 +I++TRP+ +L+ L +A PL+ P + L Sbjct: 5 TIVITRPTGQARQLIEVLTKVIEASAIAKRSLPELVSLPLLTIVPKSDEHLADSIASTLQ 64 Query: 52 ESDLLFALSQHAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQ--- 107 ++DL +S +AV L + + + + +G ++ LAL + YP Sbjct: 65 DADLAIFVSPNAVESVMRLLERDWQDFSKRIIPIGVMGGSSRLALKNHGIGQEDYPTSIY 124 Query: 108 -----DREISEVLLQLPE--LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 +R SE L Q + + K+ +I +G+GGRE + DTL GA V Y R Sbjct: 125 MPSINERWDSEGLWQELQTLDWDWTHKKVVIFKGDGGREWLADTLQKAGATVEAISTYTR 184 Query: 161 CAIHYD-GAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLA 219 + D A + + ++ ++TS E ++ L +I + L L +A Sbjct: 185 VPLDIDNPAWQVIHEMDFSKSLWLLTSSEAVRYLGEVIRDQFPY-GLESASALCPHHNIA 243 Query: 220 KLARELGWQDIKVADNADNDALLRA 244 A +G+ ++ ++ ++AL++ Sbjct: 244 DAAEAIGFGEVFTSE-PGDEALIKT 267 >UniRef50_B0VDG2 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=14 Tax=Acinetobacter RepID=B0VDG2_ACIBY Length = 255 Score = 160 bits (404), Expect = 5e-38, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 95/259 (36%), Gaps = 19/259 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP EL L+ G PL+E L+ L + + +S Sbjct: 1 MLFINTRPDSRAAELTHALQNKGFQVESLPLLELVAQPFSESLSQLYQQLTGAQAIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKW--PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L Q K + + A+G+ TA LH + + + E SE +L L Sbjct: 61 PTAVDVGMQYLTQSGLKIDELKHIQWIAVGQATANRLHDYGIEAHV--PEVETSEGMLNL 118 Query: 119 PELQNI-AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P L + RG GGR+ + +TL +G ++ Y+R + Q Sbjct: 119 PLLHCMQKSGSVAFWRGEGGRQFMMETLQQQGIQILNFVLYRRQCPQASYSTFKHLTQNS 178 Query: 178 EVT----MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAR------ELGW 227 +V++TS + L + + C LV+ RL +L + + + Sbjct: 179 NYNLDKWLVLITSEASWKYWLELCLKNKAQP---DCVYLVLGPRLFQLVKDYRDQQQAHF 235 Query: 228 QDIKVADNADNDALLRALQ 246 I +N ++ +Q Sbjct: 236 -HIIQLENLSPSGMIHHIQ 253 >UniRef50_D0KW75 Uroporphyrinogen III synthase HEM4 n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KW75_HALNC Length = 256 Score = 160 bits (404), Expect = 6e-38, Method: Composition-based stats. Identities = 67/252 (26%), Positives = 108/252 (42%), Gaps = 17/252 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTL--GQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFA 58 ++I +TRP A +EL + +L ++PL+ F+P + + +A + D Sbjct: 7 LTIGLTRPDGANDELAKAISSLLPDATLLNWPLLTFAPIPERQKALSAMARITAGDWAIF 66 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVS--GQKILYPQDREISEVLL 116 +S AV FA D + A+G TT A+ ++ ++ P + SE LL Sbjct: 67 VSPRAVRFAHDL---HDLTALPGLHWAAVGDTTTAAIQSLFSDPPQVHRPSSTQDSEGLL 123 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 ++ + G + RG GRE + DTL G V Y+R + Sbjct: 124 ASLPIEAMRGHTVWLFRGQTGRETLADTLRQNGITVIPVPVYRRNCTRRPAH------LS 177 Query: 177 REVTMVVVTSGEMLQQLWSL---IPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKV- 232 + V+T+ E L+ L L + LLHC L+V++ R AR LG+ V Sbjct: 178 ALPSTWVITAPESLRCLRQLADTLESAEDRARLLHCNLVVINARTEARARSLGFTGAIVR 237 Query: 233 ADNADNDALLRA 244 A+ D+ AL RA Sbjct: 238 AEAPDDAALARA 249 >UniRef50_C5U4M5 Uroporphyrinogen III synthase HEM4 n=1 Tax=Methanocaldococcus infernus ME RepID=C5U4M5_9EURY Length = 230 Score = 160 bits (404), Expect = 6e-38, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 84/246 (34%), Gaps = 19/246 (7%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M+++VTRP + L G P +E L D++ S Sbjct: 1 MNVIVTRPEDVAKSFCQLLTKKGYSVIKIPCLEIRY-------KKVKINLDNYDIIAFTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 V L + +R+ + IG TA + + + +E LL+ + Sbjct: 54 PRGVKGLYLNLSEDEREKVKEKIIACIGEKTAKKVEELFKKSPEIVPSEYRAEKLLEEIK 113 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + GK LI R+++ R T+ Y+ + + + Sbjct: 114 --KVEGK-ILIPTTRATRDVL------RVLHPTYIYVYESLEPENLKEKVLS-LKNLDTF 163 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 ++ TSG + + + + ++ + ++ + A+ + G I VA + Sbjct: 164 IITFTSGLIAENFLKYVDEELKKKIEENY-IIAIGPVTAERVKRFGLNPI-VAKKYTIEG 221 Query: 241 LLRALQ 246 +L A++ Sbjct: 222 ILEAIE 227 >UniRef50_B9Z5H2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z5H2_9NEIS Length = 245 Score = 159 bits (403), Expect = 8e-38, Method: Composition-based stats. Identities = 75/245 (30%), Positives = 110/245 (44%), Gaps = 13/245 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVTRP L++ L G P+++ P LA +D L +S Sbjct: 7 RILVTRPPAQSARLMALLSDAGAEPLPLPVLDIVP--DERALAALPTLAEAADWLIFVSP 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ A L ++ K +G +A L +SG+ +L+P+D S LL LPEL Sbjct: 65 SAIDAAWPVLARRKLKA----RLACVGAASAAKLAALSGRAVLHPRDGSDSAALLALPEL 120 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q + G+R LI+RG GGR +G+TL ARGA +T E Y+R D + V Sbjct: 121 QRLTGQRVLIVRGVGGRAELGETLAARGARLTLAEVYRRVDGEPD-----WSLLEQPVDA 175 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +V+TS + ++L+ L + L V R+A G I V AD+ AL Sbjct: 176 LVLTSSDTAERLFRLAGRSRSLT-LQCLLYCVPHPRIAATLAAHGVTRI-VTTQADDAAL 233 Query: 242 LRALQ 246 + L Sbjct: 234 VAGLS 238 >UniRef50_C7M2H6 Uroporphyrin-III C-methyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H6_ACIFD Length = 490 Score = 159 bits (402), Expect = 8e-38, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 90/247 (36%), Gaps = 17/247 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFAL 59 + I+VTRP + L RLR LG V P IE P LA L+ + + D L Sbjct: 245 LRIVVTRPRAVADALAVRLRDLGAVVVASPAIEIGPPSDGGAALAAALSHIEDYDWLVLT 304 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 SQ+AV + R AIG TA AL V L P + E L+++ Sbjct: 305 SQNAVDRVVGGIGDLRR--LGGVRIAAIGPATARALERVHLTADLIP-GTWVGEGLVEVF 361 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 LI R R+++ L A+G V E Y+ E + Sbjct: 362 ---GPGPGSVLIARARQARDVVPRGLEAKGWRVDVVEAYETRTAAASVPPELV----ESA 414 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +VV T+ ++ + P L+ + + GW A + D D Sbjct: 415 DLVVFTAPSTVEGFATQYP------GLVPRAAAAIGPVTEEALVRRGWPVALTATHYDAD 468 Query: 240 ALLRALQ 246 L+ ++ Sbjct: 469 GLVEVIR 475 Score = 50.2 bits (119), Expect = 6e-05, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 40/134 (29%), Gaps = 14/134 (10%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL-GESDLLFALSQ 61 +L+ R A + + L G + A L +DL+ + Sbjct: 368 VLIARARQARDVVPRGLEAKGWRVDV-----VEAYETRTAAASVPPELVESADLVVFTAP 422 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 V +Q + AIG T AL L ++ L+++ Sbjct: 423 STVEGFATQYPGLVPRAA-----AAIGPVTEEALVRRGWPVALTAT-HYDADGLVEVIRE 476 Query: 122 QNIAGKRALILRGN 135 AG+ L+ R Sbjct: 477 AREAGR--LVPRSE 488 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 30/215 (13%), Positives = 58/215 (26%), Gaps = 14/215 (6%) Query: 40 LPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTA------- 92 L AL S L + A + A P + R + Sbjct: 148 DASLDYDWRALVASGLTLVVLMGAASRATIAKELMGAGAPGETPVAVVTRASWIDEEVRW 207 Query: 93 LALHTVSGQKILYPQDREISEVLL---QLPELQNIAGKRALILRGNGGRELIGDTLTARG 149 +L + + P I V+ + + G R ++ R + + L G Sbjct: 208 TSLAALGSVPVASPSTIIIGGVVDPRRRWRPSLPLGGLRIVVTRPRAVADALAVRLRDLG 267 Query: 150 AEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHWLLH 208 A V + GA A + +V+TS + ++ L Sbjct: 268 AVVVASPAIEIGPPSDGGAALAAALSHIEDYDWLVLTSQNAVD---RVVGGIGDLRRLGG 324 Query: 209 CRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 R+ + A+ + + + L+ Sbjct: 325 VRIAAIGPATARALERVHLTADLIPGTWVGEGLVE 359 >UniRef50_D1Y458 Porphyrin biosynthesis protein HemD n=2 Tax=Bacteria RepID=D1Y458_9BACT Length = 483 Score = 159 bits (402), Expect = 8e-38, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 87/247 (35%), Gaps = 25/247 (10%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP+ L LR LG FP I P L +L L D + S Sbjct: 255 KVLVTRPANRQGRLSRMLRDLGAEVVEFPCIAAVP------LETKLPPLDVHDWIGFTSA 308 Query: 62 HAVAFAQSQLHQQDRKWPRL--PDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 V ++L + R L A+G TA AL + L P L Sbjct: 309 TGVECFFARLTAEGRDVRELGSAKIAAVGPATAAALRERGLRPDLIPA-VYDGVHLGAEL 367 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G L+ R G + +TL RG + Y+ A +Q +V Sbjct: 368 AK---RGGSVLLFRALDGSPELTETLRGRGVDFDEVPLYRT-------ETLAAPFQPADV 417 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+ TS ++ P L + + A+ A LG ++I+VA A + Sbjct: 418 DAVLFTSASTVRGFKKACP------GLEAPLACCIGVQTAREAERLGLKNIRVAARATLE 471 Query: 240 ALLRALQ 246 L+ L+ Sbjct: 472 DLVNILK 478 Score = 45.6 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 38/122 (31%), Gaps = 7/122 (5%) Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQA 176 + + K+ L+ R + + L GAEV C + + Sbjct: 244 AWRQTLPLRDKKVLVTRPANRQGRLSRMLRDLGAEVVEFPCIAAVPLETKLPPLDVH--- 300 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADN 235 + TS ++ ++ + R+ L ++ V A RE G + + Sbjct: 301 ---DWIGFTSATGVECFFARLTAEGRDVRELGSAKIAAVGPATAAALRERGLRPDLIPAV 357 Query: 236 AD 237 D Sbjct: 358 YD 359 >UniRef50_D2RGG8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RGG8_ARCPR Length = 231 Score = 159 bits (402), Expect = 9e-38, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 81/248 (32%), Gaps = 27/248 (10%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + + RP E V + G P I+ P + D+L S Sbjct: 1 MKVAILRPEHVASETVDMFKKQGFDVISIPFIKIVP-------RNFEFDPRNYDVLIVTS 53 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A K + + AIG+ TA L + R S L + + Sbjct: 54 RTAARIVVE-------KGIKHENVIAIGKKTAEELRKAGIHAKI--PTRFDSTTLYEEFK 104 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + GKR ILR N G ++ + V Y G ++ + Sbjct: 105 -DELKGKRVAILRSNRGDPILLNL-----PNVDEVILYDIEF--EWGEKQKKFLNDLDFD 156 Query: 181 MVVVTSGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 ++V +S ++ + L + L ++ + + + G + + + Sbjct: 157 VIVFSSRMTVKSFFGLADHLGIDIVERLKDKIVIAIGPPTREELSKYGIE-ALMPEEWTF 215 Query: 239 DALLRALQ 246 D++L+ L+ Sbjct: 216 DSILKLLK 223 >UniRef50_Q7P209 Uroporphyrinogen-III synthase n=1 Tax=Chromobacterium violaceum RepID=Q7P209_CHRVO Length = 243 Score = 158 bits (401), Expect = 1e-37, Method: Composition-based stats. Identities = 84/245 (34%), Positives = 116/245 (47%), Gaps = 11/245 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L RP L+ +LR G A H PL+E P + A +D LF +S Sbjct: 3 RVLAARPLAQCAGLLEKLRAEGWQAGHLPLMEIEPLPEALAALPAQA--ARADALFWVSP 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A+ L D +G +A L +SG+ +L+P SE LL LPEL Sbjct: 61 SAIDVGWPALAGMDF---SGKRLACVGAASARRLADLSGRPVLHPTAGSDSEALLALPEL 117 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + +G+R LI+RG GGR L+ DTL ARGAEV E Y+R DGA + + A Sbjct: 118 ADASGQRWLIVRGQGGRPLLADTLAARGAEVGVAEVYRRV----DGAPDWAAFDAAPPDA 173 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V++TSGEM++QL+ L R L V R+A+ G I V AD+ AL Sbjct: 174 VIITSGEMVEQLFRLAGPR-RTGALQCLLYCVPHPRIAERLAAFGAARI-VTTRADDAAL 231 Query: 242 LRALQ 246 + L+ Sbjct: 232 VAGLK 236 >UniRef50_C3WG36 Uroporphyrinogen-III synthase n=17 Tax=Fusobacterium RepID=C3WG36_FUSMR Length = 488 Score = 158 bits (401), Expect = 1e-37, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 76/246 (30%), Gaps = 13/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTR E ++ +G A P I+ L L S Sbjct: 255 KVLVTRDKRQAREFSDKIEKIGGFAIELPFIKIESTLDKID----REMLKSYSTLLFNSP 310 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 + V +++ D + A+G T L + P++ + E L + Sbjct: 311 NGVREFMNKIE--DIRDIAHLKIGAVGSKTKELLERYKIKADFIPKE-YLVEKLAKEAIH 367 Query: 122 QNIAGKRALILRGNGGRELIGDTLTA-RGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 ++ LI+ + L + Y+ I D E + +V Sbjct: 368 YTAVEEKILIITSDI-SPCDTKKLNSIYDRHFDKIVAYKTKKIIRDKEEVLDTLK--KVE 424 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 +V S + I Y + + + + ++ ++ G A D + Sbjct: 425 IVTFLSSSTVDAFMESIE--YDIESVKNIKFASIGPVTSETIKKYGLTVDFEAKVYDANG 482 Query: 241 LLRALQ 246 ++ A++ Sbjct: 483 IIEAIK 488 >UniRef50_A3CL79 Uroporphyrinogen-III synthase, putative n=1 Tax=Streptococcus sanguinis SK36 RepID=A3CL79_STRSV Length = 241 Score = 158 bits (401), Expect = 1e-37, Method: Composition-based stats. Identities = 37/241 (15%), Positives = 75/241 (31%), Gaps = 17/241 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I+ TR + ++R G H PLI + L +D +F S Sbjct: 4 KIIFTREQAPDSAWLEKIRQAGFETHHVPLIRCQSLPLPEAVQAILPE---ADWVFFTSA 60 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 AV L IG T+ AL + + + + +L Sbjct: 61 VAVEAFSPYLK-------ADYQIATIGPQTSQALDKLGRACDFQASSHYGLDFIQEWLDL 113 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 + ++ L+ + + + + L G EV Y + + +V + Sbjct: 114 A-LQTQKILLPQSSLSNPSLAEKLKEAGHEVWAWPMYATTSNPAGQDQLETYLSQEDV-I 171 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 S Q ++ P H ++ V+ + A+ E G++ + + + Sbjct: 172 WTFASPSAWQSFCAIKPHLASSH-----QIAVIGQTTAQAVEESGYRVDYQPQSPSVEEM 226 Query: 242 L 242 + Sbjct: 227 V 227 >UniRef50_C9M5W2 Porphyrin biosynthesis protein HemD n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W2_9BACT Length = 493 Score = 158 bits (399), Expect = 2e-37, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 77/247 (31%), Gaps = 22/247 (8%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++VTR + L G P I+ P L+D G+ + L S Sbjct: 251 LTVVVTRGASDAPRFAGTLARWGARVLVRPSIDPRADFSSPALSDF--RPGQHEWLVFTS 308 Query: 61 QHAVAFAQSQLHQQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 H V F L Q+ A+G TA L L P D S L + Sbjct: 309 AHGVEFFFQWLAQKGWDVRAFAGAKIAAVGPATARELEARGLIVDLVP-DVFDSAHLAEA 367 Query: 119 PELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQARE 178 + + R +++ + G + Y+ + + Sbjct: 368 LAARKTSSA--AAFRAWEATDVLSREMARSGCRLDEYPLYRNEMDGGEVGSLSA------ 419 Query: 179 VTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 V S ++ R L + A+ A++LG+Q + A A Sbjct: 420 -DWVTFASPSAVRGFVRRWKAPG-------ARALCIGPTTAEEAQKLGFQTV-TARQATF 470 Query: 239 DALLRAL 245 +++ AL Sbjct: 471 ESMTAAL 477 Score = 66.8 bits (162), Expect = 6e-10, Method: Composition-based stats. Identities = 28/206 (13%), Positives = 55/206 (26%), Gaps = 19/206 (9%) Query: 55 LLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAI------GRTT--------ALALHTVSG 100 L+F + A+ L + G T A + Sbjct: 167 LVFLMGTSALEEIAEGLIGAGLD--ESTPAAVVERGGMKGERTVRGTLGSIAGLARSAGV 224 Query: 101 QKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQR 160 ++ + L ++ + ++ RG TL GA V Sbjct: 225 ASPALAVVGGVASLNLDFSDMLPLKDLTVVVTRGASDAPRFAGTLARWGARVLVRP--SI 282 Query: 161 CAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYRE-HWLLHCRLLVVSERLA 219 + ++ + +V TS ++ + + Q + ++ V A Sbjct: 283 DPRADFSSPALSDFRPGQHEWLVFTSAHGVEFFFQWLAQKGWDVRAFAGAKIAAVGPATA 342 Query: 220 KLARELGWQDIKVADNADNDALLRAL 245 + G V D D+ L AL Sbjct: 343 RELEARGLIVDLVPDVFDSAHLAEAL 368 >UniRef50_Q15Z16 Uroporphyrinogen III synthase HEM4 n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15Z16_PSEA6 Length = 240 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 75/244 (30%), Positives = 109/244 (44%), Gaps = 13/244 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFAL 59 M++L+ RP +R T G A LI Q+ L L L +L D + Sbjct: 1 MTVLIFRPEQKCAPSAARFITAGLPAVGVGLISTQASQEALSSLPSALGSLSSGDGIIVT 60 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S L QQ + P FA+G +TA L + +E LL L Sbjct: 61 ST----VVSQLLAQQRIELPNSATIFAVGSSTAQGLRAQG--YDVTVPLVPTTEGLLALS 114 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 L+ IAG +IL+G GGRE + LT RGA V + YQR I A WQA ++ Sbjct: 115 PLKEIAGHTVVILKGQGGREDLAQQLTQRGATVLLADIYQRIKIATPKAT--QEWQAEQI 172 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 ++ TSGE++ + + WL +VVS R ++A + G + I V+D+A + Sbjct: 173 RCIIATSGEIIDTAFE----HFDAKWLQSLPWIVVSPRTEQIAVKQGIKTIFVSDDASDQ 228 Query: 240 ALLR 243 AL+R Sbjct: 229 ALIR 232 >UniRef50_UPI0000E87D4B uroporphyrinogen III methylase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D4B Length = 247 Score = 156 bits (396), Expect = 4e-37, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 100/245 (40%), Gaps = 6/245 (2%) Query: 3 ILVTRPSPAGEELVSRL-RTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++ TRP E+ FPL E P ++ + L L L +S Sbjct: 6 LISTRPVRK--EISPTFYEENNVTFLPFPLTEILPLKEYEEFDLILQNLSSYHHLIFIST 63 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV F ++++ P IG +T L + YP++ SE LL+ Sbjct: 64 NAVDFFVARMNFYHITLPSSLIISCIGPSTKKLLQENFNTPVFYPRESFDSEHLLKSDIF 123 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 +I ++ LI+RG GGRE + L +G +T+ ECY R + D E Sbjct: 124 SDIKNQKILIIRGIGGRETLRKGLEKKGGLITYGECYTRKYLQIDLEEVRKSTYEFNRIF 183 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 +++TS E ++ WL ++V RL + +I + ++ ND++ Sbjct: 184 MLITSYESAKKFMQH-NITDHLGWLKSIHVIVNHIRLKNELNI--FSNITITEDLSNDSI 240 Query: 242 LRALQ 246 LR L+ Sbjct: 241 LRILK 245 >UniRef50_B3R610 BIFUNCTIONAL: UROPORPHYRIN-III C-METHYLTRANSFERASE AND UROPORPHYRINOGEN-III SYNTHASE TRANSMEMBRANE PROTEIN n=3 Tax=Cupriavidus RepID=B3R610_CUPTR Length = 712 Score = 156 bits (396), Expect = 4e-37, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 103/276 (37%), Gaps = 34/276 (12%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++VTRP+ +L L+ G FPL+ P L LA L L+ +S Sbjct: 5 TVVVTRPAGQSRQLTEALQGAGLDVLSFPLLAIGPAADDAPLRAALARLDTFALVVFVSP 64 Query: 62 HAVAFAQSQLHQQD----RKWPRLPDYFAIGRTTALALHTVSG----------------- 100 +A+AFA L +WP +G + AL Sbjct: 65 NAIAFALDALAGVQGSAVARWPVPVAVAVVGPASVAALAERGIAAPAYRVIAPAGANANG 124 Query: 101 --QKILYPQD---REISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFC 155 P R SE L + +AGK LI+RGNGGR+ +GD L GA+V Sbjct: 125 AGHDDTVPDAEALRFDSEALWAQLDPAALAGKPVLIIRGNGGRDWLGDRLREAGAQVEAV 184 Query: 156 ECYQRCAIHYDG---AEEAMRWQAR-EVTMVVVTSGEMLQQLWSLIPQW---YREHWLLH 208 E YQR + ++TS E ++ L L Q + L Sbjct: 185 EAYQRTLPEPGAMQWQAVRDHLRPGAAPHAWLLTSSEAVRNLDVLARQHLSPQEDAALRQ 244 Query: 209 CRLLVVSERLAKLARELGWQDIKVADNADNDALLRA 244 + + R+A+ A LG+ I+ A + LL A Sbjct: 245 VQCIAPHARIAEQALALGFAHIQRAA-PGDAGLLAA 279 >UniRef50_B9MRJ5 Uroporphyrin-III C-methyltransferase n=2 Tax=Clostridia RepID=B9MRJ5_ANATD Length = 491 Score = 156 bits (396), Expect = 5e-37, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 92/245 (37%), Gaps = 15/245 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I +TRP + S L +LG + ++ ++ L +L E D+L S Sbjct: 253 RICITRPKSVSRNIKSLLFSLGADVVDGCCSKLVLHRE--EIDKILNSLPEYDILVFTSV 310 Query: 62 HAVAFAQSQLHQQDRKWPRLP-DYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V L +++ + D+ AIG+ TAL+L P + S+ L+++ E Sbjct: 311 NGVDSFFDYLTEKNIDVRNIKGDFAAIGKKTALSLQKRGFGVKYIPDE-HSSDGLIKIFE 369 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 + K+ L ++ + + ++L + G EV Y Sbjct: 370 NEVDKSKKILTVQSKNAGDYLKNSLESLGFEVDTIFAYSMEFTKNPNDAVYDS------D 423 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + V TS M + L + ++ + E K G + I +++ A ++ Sbjct: 424 IFVFTSSGMFRHFIECYG----VEVLSNKIVISIGEHTQKTLESFGIKSI-ISNEATDEG 478 Query: 241 LLRAL 245 ++ + Sbjct: 479 IVNKI 483 Score = 61.0 bits (147), Expect = 3e-08, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 44/121 (36%), Gaps = 2/121 (1%) Query: 126 GKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVT 185 GKR I R I L + GA+V C + + + E ++V T Sbjct: 251 GKRICITRPKSVSRNIKSLLFSLGADVVDGCCSKLVLHREEIDKILNSL--PEYDILVFT 308 Query: 186 SGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 S + + + + + + + ++ A ++ G+ + D +D L++ Sbjct: 309 SVNGVDSFFDYLTEKNIDVRNIKGDFAAIGKKTALSLQKRGFGVKYIPDEHSSDGLIKIF 368 Query: 246 Q 246 + Sbjct: 369 E 369 >UniRef50_C7R6S2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7R6S2_KANKD Length = 250 Score = 156 bits (395), Expect = 6e-37, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 104/244 (42%), Gaps = 7/244 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +I+VTRPSP GE L L G A H PLI F+ QL L + L +S+ Sbjct: 6 TIIVTRPSPMGESLCQELNDEGYRAIHCPLIRFTSNTDYSP-EQQLTLLKQHKLWIFVSK 64 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP-E 120 AV +A L Q+ A+G+ T AL L P+ SE +L L + Sbjct: 65 QAVDYALKDLSQEQLDQFLGHTLIAVGKATQKALQPYGL-SALVPKTP-DSEGILALINQ 122 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 A L++RG+ GR L+ L ++ Y R + + A + Sbjct: 123 FSLPADYPILLIRGDKGRGLLEQELGGP-YQLGVLPVYHRIELTAALPPAMQQASAEKPI 181 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 VVTSG++L+ ++ ++ S R++ LAR++G+ + A +A N Sbjct: 182 GWVVTSGQILELTDKMLSTAGITP--EQVVIISGSSRISDLARQMGYTNCYTAKDASNAE 239 Query: 241 LLRA 244 ++ A Sbjct: 240 IISA 243 >UniRef50_B2J0U6 Uroporphyrinogen III synthase HEM4 n=6 Tax=Cyanobacteria RepID=B2J0U6_NOSP7 Length = 300 Score = 156 bits (395), Expect = 6e-37, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 85/255 (33%), Gaps = 15/255 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ILVT P L ++ G + P IE +L L + E D + S+ Sbjct: 39 RILVTAPRNYAYRLSEQIIKQGGLPVFMPTIETCYLSNYAKLDAALNHIAEFDWIVFTSR 98 Query: 62 HAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + + +++ + A+G+ A +L + G+ L P + + ++ +L Sbjct: 99 NGITAFFHRMNDLNIPVSVVEKCQLCALGKD-AESLLSFCGKVDLIPTESSPAGIVAELA 157 Query: 120 ELQNIAGKRALILRGNGGR-------ELIGDTLTARGAEVTFCECYQRCAIHYDGAEE-A 171 ++ I K+ LI + L G EV Y ++ Sbjct: 158 KIPQIHNKKVLIPAPEVVGLPEPDVVPNLITDLQQLGTEVIRVPTYITQGLNTSIYSIEL 217 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + ++ +S ++ +++ + C + AR+LG Sbjct: 218 NLIHQGMIDVIAFSSTAEVESFLTMV---NSQSDYEGCIVACFGPYTTANARKLGVNVSI 274 Query: 232 VADNA-DNDALLRAL 245 V+ + + A+ Sbjct: 275 VSRDYSSFEGFAEAI 289 Score = 42.1 bits (98), Expect = 0.016, Method: Composition-based stats. Identities = 19/128 (14%), Positives = 35/128 (27%), Gaps = 10/128 (7%) Query: 2 SILVTRPSPAGEE-------LVSRLRTLGQVAWHFPL-IEFSPGQQLPQLADQLAALGES 53 +L+ P G L++ L+ LG P I + + L G Sbjct: 166 KVLIPAPEVVGLPEPDVVPNLITDLQQLGTEVIRVPTYITQGLNTSIYSIELNLIHQGMI 225 Query: 54 DLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISE 113 D++ S V + ++ Q G T + + +D E Sbjct: 226 DVIAFSSTAEVESFLTMVNSQSDY--EGCIVACFGPYTTANARKLGVNVSIVSRDYSSFE 283 Query: 114 VLLQLPEL 121 + Sbjct: 284 GFAEAIAE 291 Score = 41.8 bits (97), Expect = 0.021, Method: Composition-based stats. Identities = 16/124 (12%), Positives = 39/124 (31%), Gaps = 2/124 (1%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GKR L+ + + + +G F + C + +A E + Sbjct: 34 PLYGKRILVTAPRNYAYRLSEQIIKQGGLPVFMPTIETCYLSNYAKLDAALNHIAEFDWI 93 Query: 183 VVTSGEMLQQLWSLIPQWY-REHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V TS + + + + C+L + + A+ + + + + Sbjct: 94 VFTSRNGITAFFHRMNDLNIPVSVVEKCQLCALGKD-AESLLSFCGKVDLIPTESSPAGI 152 Query: 242 LRAL 245 + L Sbjct: 153 VAEL 156 >UniRef50_D1Z2S3 Uroporphyrinogen-III synthase n=1 Tax=Methanocella paludicola SANAE RepID=D1Z2S3_METPS Length = 261 Score = 156 bits (394), Expect = 9e-37, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 86/252 (34%), Gaps = 15/252 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 + VTRP+ V LR+ G A P++E P + + L L G+ D++ Sbjct: 9 RVAVTRPAKFLPAAVEYLRSKGMEAVPVPMMEMVPRKNGD-VDAFLERLSAGQVDVIILT 67 Query: 60 SQHAVAFAQSQLH---QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 SQ+ F +L + AIG T AL + + P SE ++ Sbjct: 68 SQNGFLFLLERLGDDVEHFLGLVEGVRVLAIGPKTKKALEAHAIWAKMVPS-TYSSEGIV 126 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE-EAMRWQ 175 + K +LR + G ++ L A GA V Y + + E Sbjct: 127 KEFSFPR---KHVEVLRSDHGNPVLIKGLEAGGAIVHETILYDIVPLKGEAQEAFVREAL 183 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHC----RLLVVSERLAKLARELGWQDIK 231 A + TS + L+ L + V+ A+ RE G + Sbjct: 184 AGSIDAFTFTSTMTARSLFMTAESMGVLPELKSAMNAKAVAVIGTPTAEFLRENGVRVDV 243 Query: 232 VADNADNDALLR 243 V N + ++ Sbjct: 244 VPRNFTFEEMID 255 Score = 59.1 bits (142), Expect = 1e-07, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 37/120 (30%), Gaps = 3/120 (2%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEAMRWQAREVTMVVVT 185 KR + R + L ++G E + D R A +V ++++T Sbjct: 8 KRVAVTRPAKFLPAAVEYLRSKGMEAVPVPMMEMVPRKNGDVDAFLERLSAGQVDVIILT 67 Query: 186 SGEMLQQLWSLIPQWYRE--HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 S L + + R+L + + K V ++ +++ Sbjct: 68 SQNGFLFLLERLGDDVEHFLGLVEGVRVLAIGPKTKKALEAHAIWAKMVPSTYSSEGIVK 127 >UniRef50_D0LW22 Uroporphyrin-III C-methyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LW22_HALO1 Length = 525 Score = 155 bits (393), Expect = 9e-37, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 77/258 (29%), Gaps = 14/258 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +LV R +RLR LG P+ + + Q+ S Sbjct: 260 LRVLVPRAEHQAASFAARLRELGAEPVLMPVTRVAAPAEPDPAWAQVLE-SSYTWTIFTS 318 Query: 61 QHAVAFAQSQLHQQDRKWP--RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 +AV + L + R +GR T AL L P+ + + V + Sbjct: 319 ANAVEQFFAALRARGRDARFLGGARLACVGRATEAALAAQGLICDLLPERGDAAGVAAAV 378 Query: 119 PELQNIAG-----KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM- 172 AG +R L+ R GRE L A G V Y+ D Sbjct: 379 LAASEAAGESVAAQRVLLPRAAEGREEAIAALRAAGCAVQPLTVYRSETTPSDHPSVEDG 438 Query: 173 --RWQAREVTMVVVTSGEMLQQLWSLIPQWY--REHWLLHCRLL-VVSERLAKLARELGW 227 + + V + +Q L + + + C ++ + + G Sbjct: 439 VHALRTGAIDAVAFFAPSQVQALLDIAEAAGLTQAEVVERCAIVAAIGATTQAALEQRGI 498 Query: 228 QDIKVADNADNDALLRAL 245 + + L+ AL Sbjct: 499 AVHAAPERPEAALLVEAL 516 Score = 58.3 bits (140), Expect = 2e-07, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 37/121 (30%), Gaps = 2/121 (1%) Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ 175 L E + + G R L+ R L GAE R A + + Sbjct: 249 LDWFEQRPLFGLRVLVPRAEHQAASFAARLRELGAEPVLMPV-TRVAAPAEPDPAWAQVL 307 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVAD 234 T + TS ++Q ++ + R+ +L RL V G + + Sbjct: 308 ESSYTWTIFTSANAVEQFFAALRARGRDARFLGGARLACVGRATEAALAAQGLICDLLPE 367 Query: 235 N 235 Sbjct: 368 R 368 Score = 47.2 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 41/131 (31%), Gaps = 7/131 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQ-QLPQLADQLAAL--GESDLLFA 58 +L+ R + EE ++ LR G + P + D + AL G D + Sbjct: 393 RVLLPRAAEGREEAIAALRAAGCAVQPLTVYRSETTPSDHPSVEDGVHALRTGAIDAVAF 452 Query: 59 LSQHAVAFAQSQLHQQDRKWPRLPD----YFAIGRTTALALHTVSGQKILYPQDREISEV 114 + V + + AIG TT AL P+ E + + Sbjct: 453 FAPSQVQALLDIAEAAGLTQAEVVERCAIVAAIGATTQAALEQRGIAVHAAPERPEAALL 512 Query: 115 LLQLPELQNIA 125 + L + Sbjct: 513 VEALIAARARP 523 >UniRef50_Q6FFA8 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) n=1 Tax=Acinetobacter sp. ADP1 RepID=Q6FFA8_ACIAD Length = 256 Score = 155 bits (393), Expect = 9e-37, Method: Composition-based stats. Identities = 54/229 (23%), Positives = 87/229 (37%), Gaps = 11/229 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M ++ TRP+ +EL + G + PL+ L L +S L+ +S Sbjct: 1 MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKW--PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L + + + A+G++TA AL + E SE +LQL Sbjct: 61 PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGISAEI--PQVETSEGMLQL 118 Query: 119 PELQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA----MR 173 P Q + ++ RG GGR+L+ L +G + Y R + Sbjct: 119 PVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDRQCPESATQKILSIAHDI 178 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLA 222 Q ++ V++TS SLI C LV+ ERL ++ Sbjct: 179 VQDKQPVWVLITSEASWLNWLSLIQPHAG--LFQDCHYLVLGERLEQIL 225 Score = 47.2 bits (111), Expect = 6e-04, Method: Composition-based stats. Identities = 15/114 (13%), Positives = 40/114 (35%), Gaps = 6/114 (5%) Query: 133 RGNGGRELIGDTLTARGAEVTFCE--CYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEML 190 R + + ++A+G V ++ + + ++ +VV S + Sbjct: 7 RPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQL--IVVVSPTAV 64 Query: 191 QQLWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 + + + L H R + V + AK + G ++ ++ +L+ Sbjct: 65 EIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGIS-AEIPQVETSEGMLQ 117 >UniRef50_A9A1A3 Uroporphyrinogen III synthase HEM4 n=2 Tax=Thaumarchaeota RepID=A9A1A3_NITMS Length = 267 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 86/259 (33%), Gaps = 17/259 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFAL 59 +I +TR S E +S P IE + + + L ++ D + Sbjct: 6 TIAITRSSDDASEFISLAEQTNATPIALPTIELVS-KGEKIVDEFLDSVETYNPDYSVFM 64 Query: 60 SQHAVAFAQSQLHQQD-----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S AV + + ++G T +AL T + P+ S Sbjct: 65 SSKAVKLLFDTAKESGKLETLQLAIANTIVISVGPKTTIALETQGIKVNHQPEKTFSSVG 124 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE---EA 171 + +L N GK+ ++ R + + L G +V+ Y D ++ Sbjct: 125 VGELFTQLNAVGKKVIVPRSGASTPFLKELLNKIGIDVSEIHLYD-VCAFRDTSQWNGFR 183 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLI----PQWYREHWLLHCRLLVVSERLAKLARELGW 227 + +V VV TS ++ + ++ + L ++ + + ++ Sbjct: 184 ELFSQNKVDGVVFTSASSVRGFFEIMTKDYDENSLLDNLAKLSVVSIGPFTSDELKKFKV 243 Query: 228 QDIKVADNADNDALLRALQ 246 ++ VA+ A++ Sbjct: 244 KN-TVAEVHTVAGAFEAMK 261 >UniRef50_P10746 Uroporphyrinogen-III synthase n=15 Tax=Theria RepID=HEM4_HUMAN Length = 265 Score = 155 bits (392), Expect = 1e-36, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 85/260 (32%), Gaps = 18/260 (6%) Query: 1 MSILVTRPSPAGE----ELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLL 56 M +L+ + + + + L G A P++ F LP +++L+ + L Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFL-SLPSFSEKLSHPEDYGGL 59 Query: 57 FALSQHAVAFAQSQLHQQDRK--WPRLPD-------YFAIGRTTALALHTVSGQKILYPQ 107 S AV A+ L Q ++ W R + +G TA + + + Sbjct: 60 IFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGL--DTEGE 117 Query: 108 DREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG 167 +E L + + + L GN RE++ L +G + YQ A Sbjct: 118 TCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQ 177 Query: 168 AEEAMRW-QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELG 226 + Q + S L I + ++ + + + A+ G Sbjct: 178 GNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDN-IDQIKFAAIGPTTARALAAQG 236 Query: 227 WQDIKVADNADNDALLRALQ 246 A++ AL ++ Sbjct: 237 LPVSCTAESPTPQALATGIR 256 >UniRef50_B8G819 Uroporphyrinogen III synthase HEM4 n=3 Tax=Chloroflexus RepID=B8G819_CHLAD Length = 254 Score = 155 bits (391), Expect = 2e-36, Method: Composition-based stats. Identities = 65/247 (26%), Positives = 103/247 (41%), Gaps = 16/247 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFAL 59 I +TRP+ G+ L +RLR LG + PLI ++P L LA L G D L Sbjct: 8 RIAITRPAGRGDTLAARLRALGAIPLLTPLIAYAPPADPAPLQHALAQLAAGTYDWLVVT 67 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S+ AV P A+G+ TA G++ D E+ L + Sbjct: 68 SRQAVQVLAEA------TVPTTTAIAAVGKATAADCRRTWGREPAGVPDEELGAALPNV- 120 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + GKR L+ + + L A GA V Y+ + AE A ++ + Sbjct: 121 -MGTLTGKRILLPCADIAPSTLTAALQAAGAIVDRVTAYRTIS-SPAAAELAAALRSGTI 178 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V+ SG +Q+ +L+P + L+ + A + ELG +A ++D Sbjct: 179 DAIVLASGSAARQIPALLPPQTQCP-----PLVCIGPSTAAVCTELGLPVAAIAIRPNDD 233 Query: 240 ALLRALQ 246 ALL AL+ Sbjct: 234 ALLAALE 240 >UniRef50_B9QSU4 Uroporphyrinogen-III synthase n=2 Tax=Labrenzia RepID=B9QSU4_9RHOB Length = 237 Score = 155 bits (391), Expect = 2e-36, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 76/246 (30%), Gaps = 14/246 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M LVTRP P + RLR LG A PL+ F P L D L S Sbjct: 1 MRFLVTRPRPDCKRTADRLRALGHEADEMPLLHFRPCPPPS------FDLSSIDALALTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + AV H F +G TA A + + L L Sbjct: 55 RRAVDAIT---HHAQLTQLTSLPAFTVGDKTASACREAGFEDVRSADS--DVAGLASLIL 109 Query: 121 LQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + L L +G L G Y+ + R + Sbjct: 110 SSAGSDLCKVLYLSAEQRSGDLGRLLEKGGVTCRTLPVYRMEPVQDLPKTVFARLANGDY 169 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V+V S + L L EH + +S + A+ + G+ D+ +A D Sbjct: 170 AGVLVFSRRTGETLARLFAAHLPEHIFSDLPVYAISGQAAEGLQ--GFNDVHIASAPRED 227 Query: 240 ALLRAL 245 AL L Sbjct: 228 ALFDLL 233 >UniRef50_O48721 Uroporphyrinogen-III synthase, chloroplastic n=14 Tax=Magnoliophyta RepID=HEM4_ARATH Length = 321 Score = 155 bits (391), Expect = 2e-36, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 75/248 (30%), Gaps = 15/248 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTR +++ L G + PLI+ + G +LA L D + S Sbjct: 67 VVVTRERGKNNQIIKALEKNGISSLELPLIQHARGPDFDRLASVLND-KSFDWIIITSPE 125 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTV-----SGQKILYPQDREISEVLLQ 117 A + +G TA + + + +VL Sbjct: 126 AGSVFLEAWKTA---SSPEVQIGVVGAGTARVFEEAMKSADGLLHVAFTPSKATGKVLAS 182 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 + L I + L+ RG EV Y + + + Sbjct: 183 ELPEKVGKRSSVLYPASLKAGNDIVEGLSKRGFEVVRLNTYTTVPVQSVDTVLLQQALSA 242 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 V + V S ++ LI + + + E A AR LG +++ + Sbjct: 243 PV--LSVASPSAVRAWLHLIQNEEQWSN----YVACIGETTASAARRLGLKNVYYPEKPG 296 Query: 238 NDALLRAL 245 + + ++ Sbjct: 297 LEGWVESI 304 >UniRef50_A3WKE6 Uroporphyrinogen-III synthase n=1 Tax=Idiomarina baltica OS145 RepID=A3WKE6_9GAMM Length = 241 Score = 155 bits (391), Expect = 2e-36, Method: Composition-based stats. Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 12/242 (4%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 L+ +P + + ++ L I+ P P + + D + +S++A Sbjct: 8 LILQPDDSRQRIIGALSESAIQFTQHSFIDIEPISVKPLVN------PDYDGVIWISKNA 61 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQN 123 V FA ++ FA+G TTA G P + SE LL LPE+ N Sbjct: 62 VKFA----ADAGFRFLPQTSMFAVGPTTARLAANTFGISAYCPTYKHDSESLLTLPEMVN 117 Query: 124 IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVV 183 + ++ LI++G GR+L+ DTL ARGA V+ + Y+R + + +W V ++V Sbjct: 118 VDNQKWLIIKGEKGRDLLFDTLRARGATVSSIDVYRRVKRPLNDETQVTQWMN-TVNLIV 176 Query: 184 VTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 VTS E L S +P+ WL C +V SERL L + I V +A ++ Sbjct: 177 VTSAEQLGYFLSSLPREAG-GWLSRCDWIVPSERLRDLIPFVAADTITVTGSATESKMIE 235 Query: 244 AL 245 A+ Sbjct: 236 AI 237 >UniRef50_Q48AW9 Uroporphyrinogen-III synthase n=1 Tax=Colwellia psychrerythraea 34H RepID=Q48AW9_COLP3 Length = 253 Score = 153 bits (387), Expect = 5e-36, Method: Composition-based stats. Identities = 81/252 (32%), Positives = 120/252 (47%), Gaps = 15/252 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 + +L+TRP ++L L G + L ++ +A L +D+L +S Sbjct: 6 LKVLITRPKAKAQQLALLLNQQGILNTSQTLFDYQKNASANDIATA---LENADILIFVS 62 Query: 61 QHAVAFAQSQLHQQDRKWPRLPD--YFAIGRTTALALHTVSGQKILYPQ-DREISEVLLQ 117 AV FA + P FA+G T AL + IL P +E SE LL+ Sbjct: 63 VAAVEFAHAS-----YPLPNNLSQTIFAVGNATKKALQAIGMTTILSPPPQQEHSEGLLK 117 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 LP+L + GKR +I RGNGGRE I ++LT RGAEV + E YQR A +W+A+ Sbjct: 118 LPQLSKVIGKRIIIFRGNGGREHIANSLTLRGAEVRYIESYQRVWRTLPII-IAEQWRAQ 176 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREH---WLLHCRLLVVSERLAKLARELGWQDIKVAD 234 ++ +VVTS ++L L + W C +VVS+R+ K A+ LG + + Sbjct: 177 KINCIVVTSNDILLALLKYLASTTNSTDNYWQSQCLWVVVSDRIEKNAKALGLKRVINTH 236 Query: 235 NADNDALLRALQ 246 A + L LQ Sbjct: 237 GASSQILCNTLQ 248 >UniRef50_B3T2T9 Putative Uroporphyrinogen-III synthase HemD n=1 Tax=uncultured marine crenarchaeote HF4000_ANIW93H17 RepID=B3T2T9_9ARCH Length = 273 Score = 153 bits (386), Expect = 6e-36, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 99/262 (37%), Gaps = 20/262 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESD--LLFAL 59 +I +TR +E + + P IE G+ + + L+AL E D + Sbjct: 10 TIAITRSKDDSQEFIDLITREKGNVLPLPTIELV-GKGEKIVDEFLSALAEGDPDYSVFM 68 Query: 60 SQHAVAFAQSQLHQQD-----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEV 114 S AV+ + R A+G T AL + + PQ R S Sbjct: 69 SSKAVSLLFETAKKAGKFEELRLAVANTIVLAVGPRTKDALEKENVKVAYMPQ-RYSSVG 127 Query: 115 LLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAM 172 + ++ N GK+ +I R + + L G +VT Y CA E Sbjct: 128 IGEVFTKLNAVGKKVIIPRSGASTPFLKELLEKIGLDVTELYLYDVCAFRDTSQWNEFRQ 187 Query: 173 RWQAREVTMVVVTSGEMLQQLWSLIPQWYREH----WLLHCRLLVVSERLAKLARELGWQ 228 + +V ++ TS ++ + ++ + + ++ L ++ + A ++L + Sbjct: 188 LFSQNKVDGIIFTSVSSVRAFFEIMQKDHDKNKLVDMLHETIVISIGPFTADELKKLNVE 247 Query: 229 DIKVADNADN----DALLRALQ 246 ++ +AD DA+++AL Sbjct: 248 NV-IADVHTVSGSFDAIVKALS 268 >UniRef50_B1Y161 Uroporphyrinogen III synthase HEM4 n=1 Tax=Leptothrix cholodnii SP-6 RepID=B1Y161_LEPCP Length = 267 Score = 152 bits (385), Expect = 9e-36, Method: Composition-based stats. Identities = 69/253 (27%), Positives = 101/253 (39%), Gaps = 14/253 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQ-LAALGESDLLFALSQ 61 +LVTRP P +E V RLR LGQ A PL+ P L + ++ +S Sbjct: 12 LLVTRPQPQADEWVERLRGLGQPACAAPLMVIEPVAAFAAAVQAAWQRLADCRMVMFVSP 71 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY-----PQDREISEVL- 115 +AV +Q WP A G T AL + D+ +E L Sbjct: 72 NAVLQFFAQ-RPAGLPWPTDTLAAATGPGTVAALQSKGVAAAQIVAPAADADQFDAETLW 130 Query: 116 LQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGA--EEAMR 173 LQ E Q AG++ LI+RG GR+ + TL GA+V Y+R A + G + R Sbjct: 131 LQRLESQTWAGRQVLIVRGEDGRDWLASTLRHHGAQVDLLAAYRRTAPAWSGELLDLLQR 190 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHW--LLHCRLLVVSERLAKLARELGWQDIK 231 + R + S + Q + W L + R+A+ A LGW+ + Sbjct: 191 VRQRPQDYAWLFSSSQAIGHLAAFMQTAPQAWRALHDVPAVATHLRIAQTATSLGWRTVL 250 Query: 232 VADNADNDALLRA 244 + AL+ A Sbjct: 251 --PLTPDAALIAA 261 >UniRef50_A2SK65 Uroporphyrinogen-III synthase n=1 Tax=Methylibium petroleiphilum PM1 RepID=A2SK65_METPP Length = 275 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 100/261 (38%), Gaps = 18/261 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP E V+RL G A PLI + L + LL +S Sbjct: 1 MRVLVTRPEEQAREWVARLTERGVAAAALPLIAIEAPADPAPVRLAWQTLPQRSLLVFVS 60 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQK---ILYPQD--REISEVL 115 +AV SQ +W + + G T+ AL + P D R SE L Sbjct: 61 PNAVTQFFSQ-RPAGCEWQATLRFGSPGPGTSAALRAAGVAPGAIVEPPPDAGRFDSEAL 119 Query: 116 LQLPELQNI-AGKRALILRGN-------GGRELIGDTLTARGAEVTFCECYQRCAIHYDG 167 + Q G+ LI+RG+ GRE + L GA + Y+R D Sbjct: 120 WAVLGPQGPWQGRSVLIVRGSVDGEAQGQGREWLSQVLRDAGASIDLVAAYRRAPPRLDA 179 Query: 168 AEEAMRWQAREV---TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARE 224 A +A+ A + + +S E + QL +L + L R+A+ AR Sbjct: 180 AGQALWAAALAAPVEHVWLFSSSEAIDQLDALAAAAGTAPDWRTAQALATHPRIAQRARR 239 Query: 225 LGWQDIKVADNADNDALLRAL 245 G+ + A +A++ A+ Sbjct: 240 AGFGRVIEAP-PTLEAVVAAI 259 >UniRef50_UPI00003C04D4 PREDICTED: similar to uroporphyrinogen III synthase n=1 Tax=Apis mellifera RepID=UPI00003C04D4 Length = 266 Score = 150 bits (380), Expect = 4e-35, Method: Composition-based stats. Identities = 39/252 (15%), Positives = 85/252 (33%), Gaps = 11/252 (4%) Query: 2 SILVTRPSPA----GEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLF 57 +++ R E V L+T G + P + F + +L + L Sbjct: 7 KVVLCRGLSEKNDSQEAYVKTLKTAGYLCDCLPTLRFE-FVNISELRTCFLSSSSYYGLV 65 Query: 58 ALSQHAVAFA-QSQLHQQDRKWP-RLPDYFAIGRTTALALHTVSGQKILYPQDREISEVL 115 S+ A S D P + + +G T + G + + ++ ++ L Sbjct: 66 LTSRRAAEAIELSAKEDPDILLPWKTLPVYCVGPATESFAKSHLGSENCFGKEAGNAKEL 125 Query: 116 LQLPELQ-NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 +L K L GRE I TL ++ Y+ A + ++ Sbjct: 126 AELLVASIEKKSKPLLYPCSEIGRETIEKTLNENDIKIHKIVVYKTLASKTLEHDLL-KF 184 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + + S ++ + +L+ + + L + + + + + + G + A+ Sbjct: 185 MDNVPKIFIFFSPSTVEYIVTLLKKKSYD--LNNIKAVAIGPVTRQALLDAGLKVFATAN 242 Query: 235 NADNDALLRALQ 246 D +LL A+ Sbjct: 243 KPDPVSLLDAIN 254 >UniRef50_Q12WZ2 Uroporphyrinogen-III synthase n=4 Tax=Methanosarcinaceae RepID=Q12WZ2_METBU Length = 266 Score = 150 bits (380), Expect = 4e-35, Method: Composition-based stats. Identities = 44/259 (16%), Positives = 78/259 (30%), Gaps = 18/259 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES--DLLFALS 60 I + RP + + G P+IE + + D + S Sbjct: 10 IAIMRPESYVVKSRELAESFGFEVVAIPMIEIEGMKD-EYFDAFAENIFSGISDYVIFTS 68 Query: 61 QHAVAFAQSQLHQQD----RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 + + S++ + AIG TT L + + P SE L+ Sbjct: 69 ANGIDHTLSKITPDRHSKFIDALNNTNVVAIGPTTRKQLEGIGIGVMGMP-GVYSSEGLV 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDGAEEAMRWQ 175 + ++ GK+ R G L+ L GA V + Y E + Sbjct: 128 EYLCP-DVKGKQIDTARSAYGSSLLISGLRDCGANVLETKVYTLTLPKGPLQDELITKSV 186 Query: 176 AREVTMVVVTSGEMLQQLWS----LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 E+ + TS M++ + L L + + + A +E G + Sbjct: 187 NGEIDVFAFTSSMMVRSFFDRAEALCEGKSIREVLENSLVAAIGIPTANTLKEYGVEVNV 246 Query: 232 VADNADNDALL----RALQ 246 D +L AL+ Sbjct: 247 TPDEYTFKEILRVAKAALE 265 >UniRef50_C1EAM2 Urophorphyrin III synthase n=2 Tax=Micromonas RepID=C1EAM2_9CHLO Length = 323 Score = 150 bits (379), Expect = 4e-35, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 76/251 (30%), Gaps = 15/251 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++TR ++ SRL G PLIE G L L + S Sbjct: 78 VVLTREEGKNGDMCSRLTARGIDCLEMPLIETINGADRDALPAALNDPEGWTWVCITSPE 137 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A + R +G TA L L S+ ++ Sbjct: 138 AAKVFLEGWTEAGRP---DLPIATVGAGTARILAEHYASGALAAPTFTPSKANADTMVVE 194 Query: 123 NIAGK--RALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHY-DGAEEAMRWQAREV 179 + R L + D L ARGA VT + Y + D A A A Sbjct: 195 LPVDESSRVLYPASAKAASTLQDGLAARGATVTRLDTYSTENVTAVDPAVLARALAA--- 251 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 +V S ++ +L H + AK ++G + ++ D Sbjct: 252 DVVTFGSPSAVKAWMALSG--LDPAASDHPAYACIGGTSAKACDKIGLPGVLFPEDPGVD 309 Query: 240 A----LLRALQ 246 +L+AL+ Sbjct: 310 GWEGVVLKALE 320 Score = 56.0 bits (134), Expect = 1e-06, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 34/109 (31%), Gaps = 3/109 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L + A L L G + LA +D++ S Sbjct: 202 RVLYPASAKAASTLQDGLAARGATVTRLDTYSTENVTAVDP--AVLARALAADVVTFGSP 259 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDRE 110 AV L D P Y IG T+A A + +L+P+D Sbjct: 260 SAVKAWM-ALSGLDPAASDHPAYACIGGTSAKACDKIGLPGVLFPEDPG 307 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 35/119 (29%), Gaps = 4/119 (3%) Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 E + AG+ ++ R G + LTARG + + A A Sbjct: 69 ETEQYAGRCVVLTREEGKNGDMCSRLTARGIDCLEMPLIETINGADRDALPAALNDPEGW 128 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 T V +TS E + + R + V A++ E A Sbjct: 129 TWVCITSPEAAKVFLEGWTEAGRPDL----PIATVGAGTARILAEHYASGALAAPTFTP 183 >UniRef50_Q2KYG5 Uroporphyrinogen-III synthase n=5 Tax=Bordetella RepID=Q2KYG5_BORA1 Length = 266 Score = 149 bits (378), Expect = 5e-35, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 92/255 (36%), Gaps = 19/255 (7%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHA 63 ++TRP E L RLR G P + + DL+ +S +A Sbjct: 13 VLTRPEGRNEALAGRLRAAGWEVCVLPALRIVALPAPRA-----PRPEDYDLVVFVSGNA 67 Query: 64 VAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSG----QKILYPQ---DREISEVLL 116 Q++ WP +G +A AL +LYP SE L Sbjct: 68 ARLYLKQVYASAGAWPAATVAATVGPGSAQALFESGYFGANTTVLYPDISAPTHDSEALW 127 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAE---EAMR 173 Q+ Q +R L++RG GR + + L GA+VT YQR +D A Sbjct: 128 QVLSAQGALPRRVLLVRGTQGRNWLAERLREAGAQVTAYAAYQRLPAQWDAATLDALRAW 187 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAK--LARELGWQDIK 231 + V ++TSGE + + + I + W +CR ++ L G Sbjct: 188 ARQGRVATWLLTSGESIDAVAAQIARADLLSWWRNCRYVITHPVLRGRLTLSFAGEGSAA 247 Query: 232 VADN--ADNDALLRA 244 + ++A+ A Sbjct: 248 MVKECMPADEAIFEA 262 >UniRef50_A5KJC6 Putative uncharacterized protein n=4 Tax=Bacteria RepID=A5KJC6_9FIRM Length = 515 Score = 149 bits (378), Expect = 6e-35, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 81/257 (31%), Gaps = 25/257 (9%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGES---DLLFALS 60 LVTRP L RLR LG P I +L L + S + S Sbjct: 260 LVTRPRQNSSALAKRLRNLGAQVIEMPSIHTVAIDPNERLKKALGEIQHSEKEEWFVFTS 319 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRT----------TALALHTVSGQKILYPQDRE 110 V QL ++ RL G+ TA AL + P+ Sbjct: 320 PIGVHVFFEQLEKEAWDMRRLLA----GKAQIKIAAIGSATAAALKEHGLFADIVPKI-Y 374 Query: 111 ISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAI--HYDGA 168 + L + I R G + L G V Y+ Sbjct: 375 NAGELGKTLAENISEYSAVTIFRAEEGSLELLPPLMETGVPVNDIALYRTEYEVSSLLRH 434 Query: 169 EEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQ 228 + +Q E+ V TS ++ I L + + + E+ A AR+ G + Sbjct: 435 KIEKMFQKEEIDAVTFTSASTVKGFVKAIKNVE----LQNVSAVCIGEQTAAEARKYGMK 490 Query: 229 DIKVADNADNDALLRAL 245 I+VA AD DA+ + Sbjct: 491 -IQVAKRADMDAMTEKI 506 Score = 46.4 bits (109), Expect = 8e-04, Method: Composition-based stats. Identities = 24/189 (12%), Positives = 55/189 (29%), Gaps = 15/189 (7%) Query: 69 SQLHQQDRKWPRLPDYFAIGRTT----ALALHTVSGQKILYPQDREISEVLLQLPELQNI 124 + + ++ + + T A + I+ + +SE + + + Sbjct: 198 AAVIERGTTARQRQVCATV--KTLKQQADEAKIKAPAIIVVGKVCSLSEEF-HWIKDRIL 254 Query: 125 AGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG---AEEAMRWQAREVTM 181 GK+ L+ R + L GA+V AI + + + Sbjct: 255 GGKQFLVTRPRQNSSALAKRLRNLGAQVIEMPSIHTVAIDPNERLKKALGEIQHSEKEEW 314 Query: 182 VVVTSGEMLQQLWSLIPQWYRE-----HWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 V TS + + + + + ++ + A +E G V Sbjct: 315 FVFTSPIGVHVFFEQLEKEAWDMRRLLAGKAQIKIAAIGSATAAALKEHGLFADIVPKIY 374 Query: 237 DNDALLRAL 245 + L + L Sbjct: 375 NAGELGKTL 383 >UniRef50_C7NCC3 Uroporphyrin-III C-methyltransferase n=4 Tax=Fusobacteriaceae RepID=C7NCC3_LEPBD Length = 495 Score = 149 bits (378), Expect = 6e-35, Method: Composition-based stats. Identities = 36/249 (14%), Positives = 73/249 (29%), Gaps = 18/249 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +ILVTR + +++ LG A P I ++ L E L S Sbjct: 254 NILVTRNREKQGNISNKINELGGQALSLPFINIEYV------DFEMPDLKEYSTLLFNSI 307 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 ++V ++ D + +G TA + YP++ E L Sbjct: 308 NSVIGFMRKVK--DIRSLGNVKIGVVGEKTAEEIEKYKIIPDFYPEE-YTVERLANESVN 364 Query: 122 QNIAGKRALILRGNGG--RELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 G++ L + + E L R E Y+ + + + + Sbjct: 365 FTKEGEKILFIVSDISPVNEKKYSNLYNRNYE--KLVVYKTQKVEVEKEKAEKYIKES-- 420 Query: 180 TMVVVTSGEMLQQLWS---LIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 +++ S + L + L + + + K + G + Sbjct: 421 DILMFLSSSTFKAFADSINLSENEEIKEILKNKIIASIGPVTTKTIEKYGLKVEIEPKKY 480 Query: 237 DNDALLRAL 245 + L + Sbjct: 481 TEEGLFEKI 489 >UniRef50_Q11DF2 Uroporphyrinogen III synthase HEM4 n=1 Tax=Chelativorans sp. BNC1 RepID=Q11DF2_MESSB Length = 232 Score = 149 bits (377), Expect = 7e-35, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 78/244 (31%), Gaps = 17/244 (6%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +LVTRP P RL LG PL + P + + L S Sbjct: 3 RVLVTRPEPGASRTAGRLAALGFEPVLLPLTKIVPLP-----VETWSGAENIAALAITSA 57 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +AV L + FA+G TA + ++ L + Sbjct: 58 NAVRHTPPPL----LRDLAGLPAFAVGERTAQVAAEAGVS--VKDAGAGDADRLAERIVA 111 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 G + L+L G R + L A G V E Y + G E + R + Sbjct: 112 SVQPGSKILLLCGRIRRGTLESRLAAAGLPVRAIETYDTVPVSLSGDELSTEIGDRSIDA 171 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDAL 241 V+V S L + L + +S+R+A+ I +A DA+ Sbjct: 172 VLVYSAVAATILSPFVSS------FLTAAFIAISDRVAQNLPAGLGNRIHIAREPTEDAM 225 Query: 242 LRAL 245 L L Sbjct: 226 LSLL 229 >UniRef50_C7R377 Uroporphyrinogen III synthase HEM4 n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R377_JONDD Length = 284 Score = 149 bits (377), Expect = 8e-35, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 84/256 (32%), Gaps = 15/256 (5%) Query: 4 LVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQ--LADQLAALGESDLLFALSQ 61 L+ RP L++R+ G PLI P + L AAL + S Sbjct: 14 LILRPEGRATPLITRITHAGGHTVTAPLITREPITTDQRATLDTHTAALHTYAWVAVTSV 73 Query: 62 HAVAFAQSQLHQQDRKWPRLP-----DYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 +AV + + + P + ++G T AL + S +L Sbjct: 74 NAVDELIASIQRTHPTTPLTTVCTTTQWASVGPATTRALRAHGITVAWEATENSASGMLA 133 Query: 117 QLPELQNIAGKR--ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 Q P R L+ GN + LT+ G T Y A + A W Sbjct: 134 QWPAANTHTDPRTAVLLPLGNLATTQLETGLTSAGYTPTRVTTYLTVAHPAPPSALA-AW 192 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLL-----HCRLLVVSERLAKLARELGWQD 229 +A + V++TSG +++Q + + + E + A+ Sbjct: 193 RAGRIDAVILTSGSIVEQFVAQFGHPSPGPGPAQGNEDRPVFVAIGEPTRRAAQRHSLPI 252 Query: 230 IKVADNADNDALLRAL 245 VA A L+ AL Sbjct: 253 DAVARQASTAGLVDAL 268 >UniRef50_D1JGX5 Putative uroporphyrinogen-III synthase n=1 Tax=uncultured archaeon RepID=D1JGX5_9ARCH Length = 257 Score = 149 bits (376), Expect = 9e-35, Method: Composition-based stats. Identities = 46/252 (18%), Positives = 84/252 (33%), Gaps = 10/252 (3%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I V RP ++ G + FPL E + + + +D+ S Sbjct: 6 KIAVFRPENVLKKTKEIADRYGFDFFGFPLFELVVRKDALAEIEAVFG-EGADIAVFTSI 64 Query: 62 HAVAFAQSQLHQQDRKWPR-----LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 + V A + + AIG T L + P + S+ L Sbjct: 65 NGVKKAF-GICNGKFDLKKKFQDDNVVVCAIGPATKAELANKGLHVHIMPAE-YSSDGLK 122 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQ-RCAIHYDGAEEAMRWQ 175 + + + G R + LR + G + I L A+GA V Y R + E Sbjct: 123 SVFDAIEVKGTRIVFLRSSEGDKDIITFLDAKGAFVNDIAIYSVREIALAECEELFNELV 182 Query: 176 AREVTMVVVTSGEMLQQLWSLIPQWYR-EHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 V+ TS + + E + +++ + + A+ +E G VA Sbjct: 183 WYGPDYVIFTSSLTFRIFLKHTKELNITEKVFENAKIVAIGDPTAETIKEEGLNVDLVAQ 242 Query: 235 NADNDALLRALQ 246 + + LL+ ++ Sbjct: 243 KSTIEDLLKEIR 254 >UniRef50_D2LKB0 Uroporphyrinogen III synthase HEM4 n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LKB0_RHOVA Length = 235 Score = 148 bits (375), Expect = 1e-34, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 77/246 (31%), Gaps = 11/246 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTR LR LG PLIE A L +D L S Sbjct: 1 MRLLVTRAEQDAAPFAGELRELGHEPVLQPLIELRALDFDA------AELENTDALIVTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + + + + +G TA QK L D E L Sbjct: 55 GNTLRALEQAGA---IGGLARFPIYCVGDATARRARHCGLQKPLAVAD--TGEQLAAAIV 109 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 Q G R + + G I LT+ G Y A + A + + Sbjct: 110 AQAAPGTRFVHVAGEHLSFDIVGELTSHGMPSRSLAVYVMQAAEAFKPDIADMIERGTLD 169 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V + S + SL + +SE +A+ R L + + +++ + A Sbjct: 170 GVTLLSPRTAEIYVSLCHRHRLAECAKKLSYFCISETVAQQLRTLEPRGVYISERPNRKA 229 Query: 241 LLRALQ 246 LL ++ Sbjct: 230 LLDLVR 235 >UniRef50_UPI0000521766 PREDICTED: similar to uroporphyrinogen III synthase n=1 Tax=Ciona intestinalis RepID=UPI0000521766 Length = 251 Score = 148 bits (375), Expect = 1e-34, Method: Composition-based stats. Identities = 37/250 (14%), Positives = 82/250 (32%), Gaps = 9/250 (3%) Query: 1 MSILVTRPSPA-GEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 M I++ R S +E V+ L +G P++ F+ + D ++A + Sbjct: 1 MKIVLMRASTGCNDEYVNTLNKIG-DVTSIPVLSFN-FCNCDLIKDAISAPDSWSGIIFT 58 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S+ +V Q L + +A+G +TA + I + ++VL +L Sbjct: 59 SKRSVEAVQLSLDTPLSELWASKPCYAVGESTAKMAENLGF--ISKGGNSGNAQVLAELI 116 Query: 120 ELQN--IAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ-A 176 + + + L + G RE + LT Y+ + Sbjct: 117 VQEQKLVNNQPLLFICGQLKRETLPSVLTCNEIPFHTITAYETVKNPVVDEAVQSYVEVN 176 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 + S + Q + +++ + E A + A+ Sbjct: 177 GSPDFITFFSPSG-HRFCFNTWQSALKGDFSATKIVAIGETTAHSFASQPDISVVTAERP 235 Query: 237 DNDALLRALQ 246 + ++L + ++ Sbjct: 236 NPESLFKIIK 245 >UniRef50_C9Y9I3 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9Y9I3_9BURK Length = 268 Score = 148 bits (374), Expect = 2e-34, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 99/266 (37%), Gaps = 25/266 (9%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +++TRP + L G +W PLI+ P Q + + L + D + +S Sbjct: 5 MRVIITRPQAEAAPWLKALDAAGYTSWSLPLIDIRPAAQSAHVESAWSRLSDFDAVMFVS 64 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDY----FAIGRTTALALHTVS-----GQKILYPQDREI 111 ++AV + + F G + AL V + + Sbjct: 65 RNAVHYFFEGKAAVAPVFTAQAAIETRAFVTGPGSYSALQRVGAEPGFVDAPDFHAGQFD 124 Query: 112 SEVLLQLPELQNIAGKRALILRGN----------GGRELIGDTLTARGAEVTFCECYQRC 161 SE L + + G R LI+RG+ GR+ + G EV F Y+R Sbjct: 125 SEALWAVVRSRVTPGYRVLIVRGSTIDEGASDEGSGRDWFALQVMDAGGEVEFVVSYERQ 184 Query: 162 AIHYDGAEEAMRWQAR-EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAK 220 +D + A A + T+ V +S E ++ L P + +V R+ Sbjct: 185 RPQWDASTIAQAQAAATDGTVWVFSSSEAIRNLQHACPGVS----WAQAQAVVTHARIGD 240 Query: 221 LARELGWQDIKVADNADNDALLRALQ 246 ARE G+ ++ + AL+ +++ Sbjct: 241 AAREAGFGRVRESK-PLLPALMASIE 265 >UniRef50_A9CUB7 Uroporphyrinogen-III synthetase n=1 Tax=Hoeflea phototrophica DFL-43 RepID=A9CUB7_9RHIZ Length = 243 Score = 148 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 12/248 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP P SRLRTLG PL E Q+ D L + + L A S Sbjct: 1 MRVLVTRPEPGASRTASRLRTLGHEPVILPLFE----AQITARPDDLPPVQQVGGLIATS 56 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 A + S + + +G TA A + + + L Sbjct: 57 ARAFSIFGSNTAPAEYL---HFPVYTVGPATAQAARDAGFHDVH--EGAGSARDLAGALT 111 Query: 121 LQ---NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 Q + G L L G+ + + + LTA G + E Y+ + Y + + + Sbjct: 112 AQSGTAVDGPGLLYLAGSPRKPFLEEALTAEGLPLKVLETYRMDQLSYPTDSQILDLLSP 171 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + S SL+ + L + +S ++ E + A + D Sbjct: 172 APDAALFYSSNAALGFCSLVSTKNLDKSLQSTFFMCLSPEISSAFPETWMARVISAGHPD 231 Query: 238 NDALLRAL 245 D+LL +L Sbjct: 232 EDSLLASL 239 >UniRef50_Q9W3B3 CG1885 n=10 Tax=Drosophila RepID=Q9W3B3_DROME Length = 277 Score = 147 bits (372), Expect = 2e-34, Method: Composition-based stats. Identities = 35/251 (13%), Positives = 75/251 (29%), Gaps = 11/251 (4%) Query: 2 SILVTRPSPAGEE-LVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++++ + + L P + F + L +L +L + + S Sbjct: 7 TVIIFKSESESSDVYAETLEKHDFNPVFVPTLSFG-FKNLDELRAKLQNPDKYAGIIFTS 65 Query: 61 QHAVAFAQSQLH--QQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 V L+ + W L + +A+G T + Q + + + L Sbjct: 66 PRCVEAVAESLNLGELPGGWKMLHN-YAVGEVTHNLALSTLDQLFTHGKQTGNARALGDY 124 Query: 119 PE--LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQ- 175 L+ GN + + L G V CE Y+ GA + Sbjct: 125 IVDTFDGSRALPLLLPCGNLATDTLLSKLAENGFSVDACEVYETRCHPELGANVERALEI 184 Query: 176 -AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + + S + R+ + +L+ + + LG + A+ Sbjct: 185 YGESIEFLAFFSPSGVNCAQQYF--TSRQLSMDKWKLVAIGPSTRRALESLGQKVYCTAE 242 Query: 235 NADNDALLRAL 245 + L++ L Sbjct: 243 RPTVEHLVKVL 253 Score = 49.5 bits (117), Expect = 9e-05, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 45/120 (37%), Gaps = 4/120 (3%) Query: 13 EELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAAL--GESDLLFALSQHAVAFAQSQ 70 + L+S+L G + E +L ++ + + L S V AQ Sbjct: 147 DTLLSKLAENGFSVDACEVYETRCHPELGANVERALEIYGESIEFLAFFSPSGVNCAQQY 206 Query: 71 LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRAL 130 + + AIG +T AL ++ QK+ +R E L+++ + +R L Sbjct: 207 FTSRQLSMDKW-KLVAIGPSTRRALESLG-QKVYCTAERPTVEHLVKVLLNPQDSRERLL 264 >UniRef50_B9DNE0 Putative uroporphyrinogen III synthase n=1 Tax=Staphylococcus carnosus subsp. carnosus TM300 RepID=B9DNE0_STACT Length = 229 Score = 147 bits (372), Expect = 3e-34, Method: Composition-based stats. Identities = 35/222 (15%), Positives = 71/222 (31%), Gaps = 17/222 (7%) Query: 25 VAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDY 84 H P I+ P L + D + S++AV + + Q + + Sbjct: 19 DIIHLPFIKIKPLSFNEALLN-----HHYDWIIFSSKNAVKYFRDYFQQLNVDY-----V 68 Query: 85 FAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDT 144 AIG T + V +P++ E + ++ G R +I R + Sbjct: 69 AAIGEKTKDYCNQVGISVDFFPKN-FSQEGFIDEFKVNQ--GDRIIIPSSAAARPFLQKE 125 Query: 145 LTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREH 204 L + AEV + Y+ A + + + + S + + Sbjct: 126 LQEKNAEVVKIDLYEPEAYTENILQAISLLKRNLANGIAFASSSAADNFFKEAENLNLDS 185 Query: 205 WLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ 246 + + + E G+ K+A+ D LL+ ++ Sbjct: 186 ---NYNYYAIGRPTFEKIEEYGYT-AKIAEEQTIDGLLKIIK 223 Score = 47.9 bits (113), Expect = 3e-04, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 41/126 (32%), Gaps = 12/126 (9%) Query: 2 SILVTRPSPAGEE--LVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGE--SDLLF 57 I++ PS A L L+ L + P + ++ L ++ + Sbjct: 109 RIII--PSSAAARPFLQKELQEKNAEVVKIDL--YEPEAYTENILQAISLLKRNLANGIA 164 Query: 58 ALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S A + + +Y+AIGR T + + + + + LL+ Sbjct: 165 FASSSAADNFFKEAENLNLD--SNYNYYAIGRPTFEKIEEYGYTAKI--AEEQTIDGLLK 220 Query: 118 LPELQN 123 + + Sbjct: 221 IIKESR 226 >UniRef50_A4BAP9 Uroporphyrinogen-III synthetase n=1 Tax=Reinekea blandensis MED297 RepID=A4BAP9_9GAMM Length = 246 Score = 146 bits (370), Expect = 5e-34, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 91/248 (36%), Gaps = 12/248 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 IL+ + S L + S Q + +Q L + +S Sbjct: 3 RILIPKASREQARWQQALAGESIEPLWIDPWQMSGLPQTAEHRNQWLNLDLFSGVVCVSP 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 A + L + P + G TA L + PQ +E +L LPE Sbjct: 63 TAAEVLVAALDEFWPMPPSGVHWLCNGPRTAEVLSEAGLTPVF-PQQGHTAEQVLALPEA 121 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 Q G + LI++G GGR + TLT RGA T Y+R A+ D + +A Sbjct: 122 QCAQGDKWLIVKGEGGRVTLAQTLTERGAIATELPVYRR-AVDNDALQYMTSIRADA-DA 179 Query: 182 VVVTS---GEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADN 238 + ++S GE L + Q + W + S RL + G + ++VA A Sbjct: 180 LWLSSEFLGESLLNQGRDLWQSWTGEWWVS------SPRLKDWCQAQGCRRVRVASGATV 233 Query: 239 DALLRALQ 246 AL ++ Sbjct: 234 QALQAMIR 241 Score = 43.3 bits (101), Expect = 0.008, Method: Composition-based stats. Identities = 16/117 (13%), Positives = 36/117 (30%), Gaps = 1/117 (0%) Query: 127 KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTS 186 +R LI + + + L E + + +Q + + VV S Sbjct: 2 RRILIPKASREQARWQQALAGESIEPLWIDPWQMSGLPQTAEHRNQWLNLDLFSGVVCVS 61 Query: 187 GEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 + L + + +++ L R A++ E G + + +L Sbjct: 62 PTAAEVLVAALDEFWPMP-PSGVHWLCNGPRTAEVLSEAGLTPVFPQQGHTAEQVLA 117 >UniRef50_C5CSC8 Uroporphyrinogen III synthase HEM4 n=1 Tax=Variovorax paradoxus S110 RepID=C5CSC8_VARPS Length = 257 Score = 146 bits (370), Expect = 5e-34, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 93/256 (36%), Gaps = 19/256 (7%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 ++VTRP+ + R G A PLI P L L + L +S Sbjct: 6 VIVTRPAREAAQWADEFRAAGLDAEVLPLIAIEPAIDAEPLRAAWKRLADYAALMFVSAT 65 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILY---PQD--REISEVLLQ 117 AV + R P ++A G TA AL + P D R SE L + Sbjct: 66 AVEHFFLHAEEGQRA--TGPRFWATGPGTARALLRAGVPQDAIDAPPPDAARFDSEALWE 123 Query: 118 LPELQNIAGKRALILRG------NGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA 171 + Q G R LI+RG GR+ + + A Y+R +D A A Sbjct: 124 RVKGQVGQGVRVLIVRGGDAAGQPSGRDWLAREIDAAKGLRDTVVAYRRLPPSFDDAARA 183 Query: 172 MRWQ-AREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDI 230 + A + + +S E + L +P + R+ + AR G+ + Sbjct: 184 LALDGAAGRAVWLFSSSEAIANLCDAMPGTG----WHAACAVATHARIGEAARAAGFGAV 239 Query: 231 KVADNADNDALLRALQ 246 +V +AL+ +++ Sbjct: 240 RVCP-PLREALVASIE 254 >UniRef50_B1HVD5 Uroporphyrinogen-III synthase n=2 Tax=Bacillaceae RepID=B1HVD5_LYSSC Length = 253 Score = 146 bits (369), Expect = 6e-34, Method: Composition-based stats. Identities = 36/245 (14%), Positives = 71/245 (28%), Gaps = 10/245 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 ++L+T +V + LG A PLIE + + + D + SQ Sbjct: 11 TVLLTGT-SKTTAIVDDIAALGGHAVIAPLIETCERMDNNDAK-LMNSALQFDWVIFTSQ 68 Query: 62 HAVAFAQSQLHQQDRKWPR-LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 +AV +++ + +IG T AL + Q P +++ ++ Sbjct: 69 NAVDAFANKMGRHQISAKNFRAKIASIGTKTTTALENLGFQVSFMPS-VFSADIFVKEFP 127 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 L +RG + + D L + Y+ Q E Sbjct: 128 NIAGDHPSCLFIRGEKAKSTLKDGLP---FNLKEWTVYETIERQDQTLAIINCIQHNEDV 184 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 V+ S + + R+ + + G + A Sbjct: 185 TVIFASPSAVDVYAKSVAVHV---GWQATRVAAIGHITEAALEQYGATVDIMPSVYTMQA 241 Query: 241 LLRAL 245 ++ L Sbjct: 242 VIEEL 246 Score = 54.1 bits (129), Expect = 4e-06, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 37/121 (30%), Gaps = 2/121 (1%) Query: 123 NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMV 182 + GK L+ G I D + A G + D + + A + V Sbjct: 6 PLRGKTVLL-TGTSKTTAIVDDIAALGGHAVIAPLIET-CERMDNNDAKLMNSALQFDWV 63 Query: 183 VVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALL 242 + TS + + + + ++ + + LG+Q + D + Sbjct: 64 IFTSQNAVDAFANKMGRHQISAKNFRAKIASIGTKTTTALENLGFQVSFMPSVFSADIFV 123 Query: 243 R 243 + Sbjct: 124 K 124 >UniRef50_D1B7N0 Uroporphyrin-III C-methyltransferase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N0_THEAS Length = 494 Score = 146 bits (368), Expect = 8e-34, Method: Composition-based stats. Identities = 57/246 (23%), Positives = 83/246 (33%), Gaps = 13/246 (5%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 +++ V RP P G + RL LG A+ PL+E P +L LA+L +D + S Sbjct: 245 LTVAVCRPMPEGYQTARRLEALGADAFTLPLLEVRPTASREEL---LASLEGADTVVFTS 301 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + + AIG T +L + L P +R S L +L Sbjct: 302 PRGPKVFRDLVMDLRLL---RCRTVAIGEGTRRSLEEMGIGVDLMP-ERADSRSLAELLV 357 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA-MRWQAREV 179 G+R L LR L + + GA Y+ E WQ Sbjct: 358 SCVRPGERILFLRNRRCSPLPVEAVRRAGALALELPIYEMVPRGLPWRELILEHWQDTRP 417 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 VV S + + + E AK EL + V + D D Sbjct: 418 HAVVFGSAALAEAFADEFGPLPAGAVP-----VAWGEECAKRCGELFRRRGVVMASQDLD 472 Query: 240 ALLRAL 245 L+ AL Sbjct: 473 GLVSAL 478 >UniRef50_Q2J3D5 Uroporphyrinogen III synthase HEM4 n=14 Tax=Bradyrhizobiaceae RepID=Q2J3D5_RHOP2 Length = 265 Score = 146 bits (368), Expect = 9e-34, Method: Composition-based stats. Identities = 49/248 (19%), Positives = 81/248 (32%), Gaps = 17/248 (6%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +LVTRP P + + LR G P++ F P + + S + Sbjct: 21 LLVTRPQPDNDATAAALRAKGYDVLLAPMLRFEPAPFPDDQDT------DYTGVIVTSAN 74 Query: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQ 122 A+ Q FA+G+ TA A + ++ + L+L Sbjct: 75 ALRA---IADQPGFARLLKLPLFAVGKHTARAARDAGFKDVIVAEG---DAARLRLKVAD 128 Query: 123 NIAGKR-----ALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 ++ GK+ L L G + L G V Y+ + A + A Sbjct: 129 SVKGKKKAAGALLYLAGADLSRDLAGELREDGFHVVMQTTYRMLPVQTLPATICDEFAAN 188 Query: 178 EVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNAD 237 + V+ S + E L +S+ ++ + RE G + VA D Sbjct: 189 RIEAVLHYSRRSARAFIDATRASGIEISALAIPQCCLSDSVSDVVREAGATQVMVARTPD 248 Query: 238 NDALLRAL 245 AL AL Sbjct: 249 EKALFEAL 256 >UniRef50_Q18ES1 Uroporphyrinogen-III synthase n=6 Tax=Halobacteriaceae RepID=Q18ES1_HALWD Length = 261 Score = 145 bits (367), Expect = 1e-33, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 77/234 (32%), Gaps = 15/234 (6%) Query: 16 VSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQD 75 V L G P++ P +P++ S + S+ V Sbjct: 5 VELLEEYGITPIPDPMLSVEPTGTIPEIDTV---SDASPFVVLTSKTGVEILADAGWN-- 59 Query: 76 RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGN 135 P + IG TA A V + P + S+ L+ Q + + +I R + Sbjct: 60 ---PTVATLVCIGPRTAAAARDVGWTVDIIPTE-YSSQGLVDALADQ-VTDRSVIIARSD 114 Query: 136 GGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWS 195 G E + D L A GA VT Y+ G M E+ V TS ++ S Sbjct: 115 HGSETLIDGLDAAGAAVTETVLYKLVRPDGTGQSTVMA-AGNELDAVCFTSSLTVEHFLS 173 Query: 196 LIPQWYREH----WLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 L + + + E + A+ G + +A + L+ A+ Sbjct: 174 AAANRELREETIMGLNNAVVGTIGEPTRETAQAHGVRVDVTPADATFEHLVEAV 227 Score = 56.4 bits (135), Expect = 8e-07, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 38/130 (29%), Gaps = 7/130 (5%) Query: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 +++ R E L+ L G L + + +AA E D + S Sbjct: 108 VIIARSDHGSETLIDGLDAAGAAVTETVLYKLV-RPDGTGQSTVMAAGNELDAVCFTSSL 166 Query: 63 AVAFAQSQ-----LHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 V S L ++ IG T + + P D E L++ Sbjct: 167 TVEHFLSAAANRELREETIMGLNNAVVGTIGEPTRETAQAHGVRVDVTPADA-TFEHLVE 225 Query: 118 LPELQNIAGK 127 + G+ Sbjct: 226 AVVNELQTGQ 235 >UniRef50_Q5GRQ8 Uroporphyrinogen-III synthase n=10 Tax=Wolbachia RepID=Q5GRQ8_WOLTR Length = 235 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 34/247 (13%), Positives = 72/247 (29%), Gaps = 16/247 (6%) Query: 1 MS-ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 M IL+TRP S L+ G + P Q + D++ + Sbjct: 1 MKSILLTRPLSDSLNTRSTLKKYGYKVYIEPAFTIKHLQPDISA-------YKFDVVIST 53 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S+++V +G +T I+ E L+ Sbjct: 54 SKNSVKAFSQ------ICRVDDLPIITVGNSTMQTAKDSGFSDIISADS--NVEGLISFV 105 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + L +RG + L+ G V Y+ + Sbjct: 106 KNYYSRAVKFLYIRGQEVSCDLKKRLSEEGFNVREVILYKTIIKRGLTNRCKNLLLGGRI 165 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V S + + SL+ + + + + +S+ + + + W+ I + + Sbjct: 166 NSVAFFSSQTARIFCSLVLKSGLSNVMDNITAYAMSKNIVDSLKPIKWKKIITSRLPTQE 225 Query: 240 ALLRALQ 246 L+ + Sbjct: 226 NLIDIIN 232 >UniRef50_Q2VYV0 Uroporphyrinogen-III synthase n=3 Tax=Magnetospirillum RepID=Q2VYV0_MAGSA Length = 242 Score = 145 bits (366), Expect = 2e-33, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 80/246 (32%), Gaps = 15/246 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M LVTRP E + L+ G PL++ +P + LG + + S Sbjct: 1 MRALVTRPKEDSEGVAQALKQRGLDVMVEPLLDIAPVEG------AKPDLGGAQGILVTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + + R +A+G +A A + ++ E L +L Sbjct: 55 ANGIRAL------GRLTPGRELPVWAVGDASARAAREMGFTRVE--SAGGDVETLAELVA 106 Query: 121 LQ-NIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + + G L G + L+A G +V Y+ + ++ Sbjct: 107 ARVDPQGGALLHAAGTVTAGDLSGRLSALGFQVRRQVLYRAVTATRLSDGLRDALRNGQL 166 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 + + S + +L + L +S ++ L W+ ++ A Sbjct: 167 HLALFFSPRTARTFATLAVEAGVRDSLAAIAAYGLSANVSAELGPLPWRVLRQAAEPTQA 226 Query: 240 ALLRAL 245 ALL A+ Sbjct: 227 ALLAAI 232 >UniRef50_Q2IKT0 Uroporphyrinogen-III synthase n=4 Tax=Anaeromyxobacter RepID=Q2IKT0_ANADE Length = 264 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 82/249 (32%), Gaps = 9/249 (3%) Query: 2 SILVTRPS--PAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 +++VTR + L RL LG P I F+P L L L D Sbjct: 13 TVVVTRGKGSEGKDALAVRLEELGAEVRALPSIAFAPPADPAPLDAALRGLERFDWAVFT 72 Query: 60 SQHAVAFAQSQLHQQD--RKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQ 117 S +AV +L A+G TA L + + P + + +L Sbjct: 73 SANAVDRTVERLRALGLAPAALGRLRLAAVGPATAERLAALVRAPDVVPVEAKG--DVLA 130 Query: 118 LPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW-QA 176 + + G+R L R GR L A GAE+T E Y+ + W A Sbjct: 131 RTLGEQVRGRRVLFPRPAEGRPETVAGLLAAGAELTAVEAYRTMPAPPEALGCLAGWLAA 190 Query: 177 REVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNA 236 EV V S + + + R L + + A RE G V + Sbjct: 191 GEVAAVAFASPSAVAAVVGALGD--RSALLRGVLIAAIGPTTADALREAGLPVGAVPAHY 248 Query: 237 DNDALLRAL 245 L A+ Sbjct: 249 TGRDLAEAI 257 >UniRef50_A8J4K4 Uroporphyrinogen-iii synthase n=1 Tax=Chlamydomonas reinhardtii RepID=A8J4K4_CHLRE Length = 297 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 68/247 (27%), Gaps = 12/247 (4%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQ-LPQLADQLAALGESDLLFALS 60 +L+TR ++L + L G PLI + G A AA + + + S Sbjct: 46 KVLLTREEGKNDKLRAALTRKGYTCLELPLIAHTDGPDRPLLPALLRAAADQYEWVAITS 105 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + A+G T AL P + +V+ Sbjct: 106 PEGASVFLEGWAAAG---KPKLRVAAVGGGTGEALQAGGVTPEYVPSKA-LGKVMGSELP 161 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 +R L + D+LT G EV Y ++ Sbjct: 162 RVPGGSRRVLYPASVKASTDLQDSLTEAGFEVHRINTYNTTSVASVPEALLREALTA--D 219 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGW-QDIKVADNADND 239 +V S ++ L + + A+ G Q + D + Sbjct: 220 VVTYGSPSAVKAWVGLAGLEAANAKVN----ACIGSTSARACANAGITQHVYFPDAPGIE 275 Query: 240 ALLRALQ 246 + A++ Sbjct: 276 GWVEAVE 282 Score = 43.7 bits (102), Expect = 0.006, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 38/128 (29%), Gaps = 9/128 (7%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +L A +L L G + +P+ L +D++ S Sbjct: 169 RVLYPASVKASTDLQDSLTEAGFEVHRINTYNTTSVASVPE--ALLREALTADVVTYGSP 226 Query: 62 HAVAF--AQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 AV + L + K IG T+A A + +Y D E ++ Sbjct: 227 SAVKAWVGLAGLEAANAKVN-----ACIGSTSARACANAGITQHVYFPDAPGIEGWVEAV 281 Query: 120 ELQNIAGK 127 E K Sbjct: 282 EKGCREAK 289 >UniRef50_B6BVM6 Uroporphyrinogen-III synthase n=1 Tax=beta proteobacterium KB13 RepID=B6BVM6_9PROT Length = 247 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 106/242 (43%), Gaps = 5/242 (2%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 +++ TR S + +++ + +P IE P P++ + + + +S Sbjct: 3 NLIATRSSLQNQSIINFFKGSSLNVIDYPFIEIEPIFSTPEIKKIIDDMHLFSKIIFISS 62 Query: 62 HAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPEL 121 +A + K+ FAIG TT L + + I P D+ S+ LL+LPE+ Sbjct: 63 NAAQCFKIISEHHSIKFSDNVQIFAIGPTTKKEL-SFLKKNIFSPIDQFDSKTLLELPEI 121 Query: 122 QNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTM 181 QN+ + LI+RG GG+EL+ + L + A + + ECYQR D + +E Sbjct: 122 QNVKDESILIVRGVGGKELLKNELEKKQANIAYLECYQRIFKLIDFN-IITNYSQKETLY 180 Query: 182 VVVTSGEMLQQLWSLIPQWYREHWLL--HCRLLVVSERLAKLARELGWQDIKVADNADND 239 +++TS ++ Q + + + H +V E +AK DIK+ D + Sbjct: 181 ILITSSQIAQHFIDQLGLFGNPDQIHFDHICFIVNHENIAKELSVFEC-DIKITPTLDPE 239 Query: 240 AL 241 L Sbjct: 240 KL 241 >UniRef50_C0VHI0 Uroporphyrinogen-III synthase n=2 Tax=Acinetobacter RepID=C0VHI0_9GAMM Length = 258 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 50/231 (21%), Positives = 85/231 (36%), Gaps = 11/231 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M + TRP + L ++ G H PL+E +L L + ++ +S Sbjct: 1 MRFINTRPQDRADRLTQAMQDAGYQVEHLPLLELIAVPLSEELQQLYQQLDQVQVIVVVS 60 Query: 61 QHAVAFAQSQLHQQDRKW--PRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 AV L + + A+G+ TA AL Q + + E SE +L L Sbjct: 61 PTAVDIGMKYLVKSGLNLHQLAHIRWIAVGQATAKALAQFGIQSDV--PEVESSEGMLDL 118 Query: 119 PELQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAR 177 P L+ ++ RG GGR+ + L +G ++ Y R E + Sbjct: 119 PLLKQQNDLQKIAFWRGLGGRQFMMQQLQQQGVKIANFVLYHRQCPQQSVFEFPRLLEKM 178 Query: 178 EVT---MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAREL 225 E V+++S + L Q + + LV+ ERL + + Sbjct: 179 EPDQPVAVLISSEASWKNWLQLCAQNPCKQKWV---YLVLGERLTAILNQA 226 Score = 53.7 bits (128), Expect = 6e-06, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 41/112 (36%), Gaps = 2/112 (1%) Query: 133 RGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQ 192 R + + + G +V + A+ + + Q +V ++VV S + Sbjct: 7 RPQDRADRLTQAMQDAGYQVEHLPLLELIAVPLSEELQQLYQQLDQVQVIVVVSPTAVDI 66 Query: 193 LWSLIPQWYRE-HWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLR 243 + + H L H R + V + AK + G Q V + ++ +L Sbjct: 67 GMKYLVKSGLNLHQLAHIRWIAVGQATAKALAQFGIQSD-VPEVESSEGMLD 117 >UniRef50_Q6C2A4 YALI0F09449p n=1 Tax=Yarrowia lipolytica RepID=Q6C2A4_YARLI Length = 243 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 37/252 (14%), Positives = 77/252 (30%), Gaps = 20/252 (7%) Query: 1 MSILV----TRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLL 56 M+IL+ T P +EL + G A PL++ SP + D + Sbjct: 1 MNILLLKNPTTPRDFYQEL--FVEQKGHNAVFVPLLQHSPVGIESLKTHIANEVDGIDAV 58 Query: 57 FALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLL 116 S AV + P + +G TA L + + + + E Sbjct: 59 IVTSHRAVEILGEYASPELLCKPA----YTVGPATARCLRELGFKDV---RGEETGNGAA 111 Query: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDG---AEEAMR 173 +P+L + +R G R+ I + L G + Y+ + + Sbjct: 112 LVPQLLSDGYQRFAFYAGKVRRDTIPNKLREAGRSLVEYTVYETVDLDDIAGRFEKAVGA 171 Query: 174 WQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVA 233 + + + Q+ + + + ++ + ++ + A Sbjct: 172 LPDAKHNWICFFAPSGTAQIVEYLKKNPAHGF----KIASIGPTTLDYLQKNDIKVDVTA 227 Query: 234 DNADNDALLRAL 245 D + L A+ Sbjct: 228 KQPDPEHFLEAM 239 >UniRef50_B0C6J8 Uroporphyrinogen-III synthase n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0C6J8_ACAM1 Length = 287 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 83/246 (33%), Gaps = 14/246 (5%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQ 61 I++T P P L + + G + P IE P L L L + + S+ Sbjct: 17 RIVITAPRPYAGRLATAIIQQGGLPIVMPTIETYALDPAPDLDHALQQLRDFSWVAFTSR 76 Query: 62 HAVAFAQSQLHQQDRK--WPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 + +L Q D AIG+ A L T+ + L P++ + ++ +L Sbjct: 77 TGIQAVMLRLQQLDIPLFLLNQCHICAIGQD-ADQLQTLGVRVDLIPKESSPAGLVAELA 135 Query: 120 ELQNIAGKRALILRGNGGR-------ELIGDTLTARGAEVTFCECYQRCAIHYDGAEEA- 171 ++ +I +R + R L G V Y + Sbjct: 136 QIPDIDTRRIFVPIPQVERIPEPDIVPKFLADLEQLGLTVVSVPAYVTRRLEATAYAVEV 195 Query: 172 MRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIK 231 + + +V + +S + L ++ E + HC + A A++LG Sbjct: 196 EQIRQGKVDAIAFSSTAEISALLQMVDA---ETLMKHCVIACFGPYTAGNAKDLGLSVDI 252 Query: 232 VADNAD 237 V+ + Sbjct: 253 VSQDFS 258 >UniRef50_A8SQW3 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW3_9FIRM Length = 527 Score = 144 bits (363), Expect = 3e-33, Method: Composition-based stats. Identities = 32/262 (12%), Positives = 75/262 (28%), Gaps = 35/262 (13%) Query: 13 EELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLH 72 E++ + LG ++ + ++ +L L + + L SQ+ + L Sbjct: 265 EKMRVAIDALGGQSYSIVDMSVEQTEEKDRLRVALEHIEDYSWLAFTSQNTITLFFKWLR 324 Query: 73 QQDRKWPR--LPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRAL 130 + + + + +G T AL + P + S L G++ L Sbjct: 325 EWNIDVRKLVHLKFAVVGAGTRDALRSEGYIADYVPDEYTTS-ALAMGLANVMNDGEKLL 383 Query: 131 ILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEML 190 + R G E + D L G Y + + ++ S + Sbjct: 384 LPRAVQGSETMLDILDKGGVTYEEIPVYDVVGRRMESIQYLKDL-----DVITFVSASGV 438 Query: 191 QQLWSLIPQW---------------------------YREHWLLHCRLLVVSERLAKLAR 223 + ++ + + R+ + K Sbjct: 439 RGFLKVLDAEKNGSGMDHMPNDVDSCREHTNNTESTLKIHDIMKNIRIAALGNVTEKALE 498 Query: 224 ELGWQDIKVADNADNDALLRAL 245 + G+ V + D + L+ ++ Sbjct: 499 KAGYHADIVPEVGDIEHLISSI 520 >UniRef50_B7FUN6 Uroporphyrinogen-iii synthase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7FUN6_PHATR Length = 296 Score = 143 bits (362), Expect = 4e-33, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 78/249 (31%), Gaps = 18/249 (7%) Query: 3 ILVTRPSPAGEELVSRLRTL---GQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFAL 59 + VTR ++L+ L + P I + G+ LA++L + D + Sbjct: 50 VAVTREDGNNKKLLKALESRLAGRISVLEVPCIAHADGEDYALLAEKLRS-ERWDYVAVT 108 Query: 60 SQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLP 119 S A S A+G+ T+ AL P + ++L+LP Sbjct: 109 SPQAAIILNSAWDSVRDD---PIPVTAVGKATSEALEEYGIAVSFCPSKAIATTLMLELP 165 Query: 120 ELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 + R L R + + L RG EV Y + H+ R A + Sbjct: 166 ATRVTDATRVLYPASAKARTTLENGLRERGFEVVRLNAYDTVSAHWTH---IQRTNAEKC 222 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQD--IKVADNAD 237 + S + + + + A + R+ GW I D Sbjct: 223 QVACFGSPSAVDGWLRN------SNNNTTVLAACIGKTSADVCRDRGWPKECIFFPDKPG 276 Query: 238 NDALLRALQ 246 + + ++ Sbjct: 277 IEGWINVVE 285 >UniRef50_C6QJ56 Uroporphyrinogen III synthase HEM4 n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QJ56_9RHIZ Length = 246 Score = 143 bits (361), Expect = 5e-33, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 90/247 (36%), Gaps = 11/247 (4%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M +LVTRP GE L + L LG PLI D+ + L S Sbjct: 1 MHVLVTRPKDDGETLKAELEQLGCKVTLEPLIRIVSNDIPATAIDETSTL------IITS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 ++A+ L A+G TA + I +E++ ++ Sbjct: 55 RNALRALAKSPALTRALTRPLL---AVGPGTAALAREMGFTDIFEGPGTG-AELVPEITR 110 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G + L + + L RG + Y+ A + A + + Sbjct: 111 RSEAGGGAFVYLSADRMAFDVPSALAERGIAIRRVVAYRSVAAETLSPQVADALRDGAIN 170 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLAR-ELGWQDIKVADNADND 239 +VV+ S + + P + + L + +SE +A + + ELG Q I VA+ +++ Sbjct: 171 VVVLMSPRTSETWAKIAPVAAKPNDLSDISYVCISEAVANVVKSELGPQAIIVANRPNHE 230 Query: 240 ALLRALQ 246 +L L+ Sbjct: 231 EILIVLK 237 >UniRef50_A1VRW0 Uroporphyrinogen-III synthase n=4 Tax=Comamonadaceae RepID=A1VRW0_POLNA Length = 287 Score = 143 bits (361), Expect = 5e-33, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 96/278 (34%), Gaps = 37/278 (13%) Query: 2 SILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPG---QQLPQLADQLAALGESDLLFA 58 ++VTRP+P V +L G A F LI+ +P L D AL Sbjct: 5 RVIVTRPAPDAALWVRQLEQAGIAAEAFELIDIAPVGSAADAQALGDAWLALDAYAACLF 64 Query: 59 LSQHAVAFAQSQLHQQD-----------------RKWPRLPDYFAIGRTTALALHTVS-- 99 +S HAV + R+ P + A G T AL Sbjct: 65 VSGHAVEHFFKENKAFAQGGYAQAAINNIANSGLRRIPPGLRFMAPGPGTVAALRAAGVP 124 Query: 100 ---GQKILYPQDREISEVLLQLPELQNIAGKRALILRGN--------GGRELIGDTLTAR 148 + SE L ++ ++ G++ LI+RG GR+ I Sbjct: 125 AAQIDAPAADASQFDSEALWRVVGARDWQGRKVLIVRGQSAGAQGATSGRDWIVRQWQGA 184 Query: 149 GAEVTFCECYQRCAIHYDGAEEAMRWQA-REVTMVVVTSGEMLQQLWSLIPQWYREHWLL 207 GA V F YQR A A+ A QA + ++ + +S E + L + Sbjct: 185 GASVDFVGVYQRRAPILTDAQVARARQASADGSVWLFSSSEAVANLVGQAGLQGVDWG-- 242 Query: 208 HCRLLVVSERLAKLARELGWQDIKVADNADNDALLRAL 245 R + R+A+ R GW + + + +AL Sbjct: 243 RARAVATHPRIAQAVRAAGWGVVVES-RPALKDIRQAL 279 >UniRef50_Q2RND4 Uroporphyrinogen III synthase HEM4 n=1 Tax=Rhodospirillum rubrum ATCC 11170 RepID=Q2RND4_RHORT Length = 734 Score = 143 bits (360), Expect = 6e-33, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 74/243 (30%), Gaps = 15/243 (6%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M L+TRP + + + LR G + PL+ P L ++ L S Sbjct: 1 MRALITRPLEDADRIGALLRARGADVFLEPLLIILPAAAPG------LDLTDAQALVFTS 54 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 + V DR R +A+G TT + L L Sbjct: 55 ANGVRAF------ADRNALRRLPVYAVGETTGTVASAYGFPDVRIA--GGDVRALASLIL 106 Query: 121 LQNIAG-KRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREV 179 Q + + G + +L A G V Y+ E + R + Sbjct: 107 AQASPDAGPLVHISGTNVAGDLAGSLGAHGFTVRRERLYEARPAAAFSKELKTAFVERSM 166 Query: 180 TMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239 V + S + L+ + + + +S +A L ++VA D Sbjct: 167 PAVFLFSPRTARTFAGLVHKADLLSAMTDVTVYALSPAVADALEGLPLGAVRVAAEPTQD 226 Query: 240 ALL 242 ALL Sbjct: 227 ALL 229 >UniRef50_C1XV34 Uroporphyrinogen-III synthase n=2 Tax=Meiothermus RepID=C1XV34_9DEIN Length = 234 Score = 142 bits (359), Expect = 9e-33, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 75/246 (30%), Gaps = 28/246 (11%) Query: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 M++ +T E L RL T G H+PLI Q + L L S Sbjct: 1 MTVALTHAEGRLEGLRERLETQGYRVVHYPLIATQTLQGVS-----LEPLEACCWWLFSS 55 Query: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120 Q AV + A+G TA AL + + L + +E L + Sbjct: 56 QAAVRAVVELGGR-----FAGHRLGAVGEGTAKALRDLGLEVELVSPEGH-AESLARAFI 109 Query: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180 G + RGN + D L G EV Y+ + Sbjct: 110 AWQAPG-PVGLPRGNRALPTLADLLEGAGYEVHALTVYKTLTQPWPPDAPI-------PD 161 Query: 181 MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA 240 + V+ S ++ L + + A+ R G A + + Sbjct: 162 LTVLASPSAVEAL--------PVEVARQTHCIALGPSTAQSLRACGLS-YSQAQSPTVEG 212 Query: 241 LLRALQ 246 ++ A++ Sbjct: 213 VIAAIE 218 >UniRef50_B0W7I4 Uroporphyrinogen iii synthase n=3 Tax=Culicidae RepID=B0W7I4_CULQU Length = 267 Score = 142 bits (359), Expect = 1e-32, Method: Composition-based stats. Identities = 37/245 (15%), Positives = 84/245 (34%), Gaps = 13/245 (5%) Query: 2 SILVTRPSPAGEEL-VSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 ++V + + S L+ G P ++FS + L L D+L + + L S Sbjct: 3 KVVVLKSESDNSDTYSSLLQKHGFEPVLVPTLDFS-FKNLDVLRDRLLSPYKYSGLIFTS 61 Query: 61 QHAVAFAQSQL--HQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQL 118 ++ + L + W L + +++G T+ + + Q Q + L Sbjct: 62 PRSITAVRDALGGQRLKDDWRTLEN-YSVGETSHDLICSH-LQLNTKGQQSGNASNLADF 119 Query: 119 PELQNIAGKRA----LILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRW 174 + ++ K L GN ++++ L+ G + E Y+ + Sbjct: 120 IKT-DLYNKTITLPFLFPCGNLKQDVLQYKLSEYGYSLDSVEVYETVPHKDLERNLVQLF 178 Query: 175 QAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVAD 234 + ++ S + ++ + + L CR++ + K G + A+ Sbjct: 179 RGDAPAFLLFFSPSGINYCSAIFERNKLD--LGGCRIVAIGPSTKKAIENKGLTVYRTAE 236 Query: 235 NADND 239 D Sbjct: 237 KPSPD 241 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.308 0.155 0.411 Lambda K H 0.267 0.0483 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,592,937,034 Number of Sequences: 3077464 Number of extensions: 65682567 Number of successful extensions: 268065 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 799 Number of HSP's successfully gapped in prelim test: 506 Number of HSP's that attempted gapping in prelim test: 262145 Number of HSP's gapped (non-prelim): 1949 length of query: 246 length of database: 1,040,396,356 effective HSP length: 125 effective length of query: 121 effective length of database: 655,713,356 effective search space: 79341316076 effective search space used: 79341316076 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (20.9 bits) S2: 92 (39.8 bits)