Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	H	L	A	E	L	V	A	S	A	K	A	A	I	S	Q	A	S	D	V	A	A	L	D	N	V	R	V	E	Y	L	G	K	K	G	H	L	T	L	Q	M	T	T	L	R	E	L	P	P	E	E	R	P	A	A	G	A	V	I
Secondary structure
SS confidence
Disorder		?	?	?														?	?	?	?																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	E	A	K	E	Q	V	Q	Q	A	L	N	A	R	K	A	E	L	E	S	A	A	L	N	A	R	L	A	A	E	T	I	D	V	S	L	P	G	R	R	I	E	N	G	G	L	H	P	V	T	R	T	I	D	R	I	E	S	F	F
Secondary structure
SS confidence
Disorder																						?		?	?	?	?														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	E	L	G	F	T	V	A	T	G	P	E	I	E	D	D	Y	H	N	F	D	A	L	N	I	P	G	H	H	P	A	R	A	D	H	D	T	F	W	F	D	T	T	R	L	L	R	T	Q	T	S	G	V	Q	I	R	T	M	K	A
Secondary structure
SS confidence
Disorder																												?			?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	Q	P	P	I	R	I	I	A	P	G	R	V	Y	R	N	D	Y	D	Q	T	H	T	P	M	F	H	Q	M	E	G	L	I	V	D	T	N	I	S	F	T	N	L	K	G	T	L	H	D	F	L	R	N	F	F	E	E	D	L	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	R	F	R	P	S	Y	F	P	F	T	E	P	S	A	E	V	D	V	M	G	K	N	G	K	W	L	E	V	L	G	C	G	M	V	H	P	N	V	L	R	N	V	G	I	D	P	E	V	Y	S	G	F	A	F	G	M	G	M	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.
Sequence		R	L	T	M	L	R	Y	G	V	T	D	L	R	S	F	F	E	N	D	L	R	F	L	K	Q	F	K
Secondary structure
SS confidence
Disorder																										?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3pco chain C Region: 6 - 327 Aligned: 322 Modelled: 322 Confidence: 100.0% Identity: 100% PDB header:ligase Chain: C: PDB Molecule:phenylalanyl-trna synthetase, alpha subunit; PDBTitle: crystal structure of e. coli phenylalanine-trna synthetase complexed2 with phenylalanine and amp Phyre2 PDB 3l4g chain I Region: 72 - 327 Aligned: 253 Modelled: 256 Confidence: 100.0% Identity: 35% PDB header:ligase Chain: I: PDB Molecule:phenylalanyl-trna synthetase alpha chain; PDBTitle: crystal structure of homo sapiens cytoplasmic phenylalanyl-trna2 synthetase Phyre2 PDB 1jjc chain A Region: 91 - 327 Aligned: 237 Modelled: 237 Confidence: 100.0% Identity: 51% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain Phyre2 PDB 1b70 chain A Region: 92 - 327 Aligned: 236 Modelled: 236 Confidence: 100.0% Identity: 51% PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase; PDBTitle: phenylalanyl trna synthetase complexed with phenylalanine Phyre2 PDB 2du7 chain C Region: 82 - 320 Aligned: 236 Modelled: 239 Confidence: 100.0% Identity: 25% PDB header:ligase Chain: C: PDB Molecule:o-phosphoseryl-trna synthetase; PDBTitle: crystal structure of methanococcus jannacshii o-phosphoseryl-trna2 synthetase Phyre2 PDB 2du4 chain B Region: 68 - 320 Aligned: 247 Modelled: 250 Confidence: 100.0% Identity: 24% PDB header:ligase/rna Chain: B: PDB Molecule:o-phosphoseryl-trna synthetase; PDBTitle: crystal structure of archaeoglobus fulgidus o-phosphoseryl-2 trna synthetase complexed with trnacys Phyre2 PDB 3cmq chain A Region: 94 - 327 Aligned: 229 Modelled: 234 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase, mitochondrial; PDBTitle: crystal structure of human mitochondrial phenylalanine trna2 synthetase Phyre2 PDB 2rhq chain A Region: 81 - 327 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 56% PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase alpha chain; PDBTitle: phers from staphylococcus haemolyticus- rational protein2 engineering and inhibitor studies Phyre2 PDB 2zim chain A Region: 103 - 320 Aligned: 201 Modelled: 208 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:pyrrolysyl-trna synthetase; PDBTitle: pyrrolysyl-trna synthetase bound to adenylated pyrrolysine and2 pyrophosphate Phyre2 PDB 2znj chain B Region: 45 - 320 Aligned: 258 Modelled: 276 Confidence: 100.0% Identity: 17% PDB header:ligase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of pyrrolysyl-trna synthetase from2 desulfitobacterium hafniense Phyre2 PDB 3bju chain B Region: 110 - 314 Aligned: 188 Modelled: 204 Confidence: 99.9% Identity: 21% PDB header:ligase Chain: B: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of tetrameric form of human lysyl-trna2 synthetase Phyre2 PDB 1e22 chain A Region: 110 - 314 Aligned: 188 Modelled: 203 Confidence: 99.9% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: lysyl-trna synthetase (lysu) hexagonal form complexed with2 lysine and the non-hydrolysable atp analogue amp-pcp Phyre2 PDB 1eqr chain C Region: 110 - 314 Aligned: 187 Modelled: 202 Confidence: 99.8% Identity: 25% PDB header:ligase Chain: C: PDB Molecule:aspartyl-trna synthetase; PDBTitle: crystal structure of free aspartyl-trna synthetase from2 escherichia coli Phyre2 PDB 1efw chain A Region: 110 - 314 Aligned: 187 Modelled: 202 Confidence: 99.8% Identity: 29% PDB header:ligase/rna Chain: A: PDB Molecule:aspartyl-trna synthetase; PDBTitle: crystal structure of aspartyl-trna synthetase from thermus2 thermophilus complexed to trnaasp from escherichia coli Phyre2 PDB 3e9h chain B Region: 110 - 314 Aligned: 191 Modelled: 201 Confidence: 99.8% Identity: 20% PDB header:ligase Chain: B: PDB Molecule:lysyl-trna synthetase; PDBTitle: lysyl-trna synthetase from bacillus stearothermophilus2 complexed with l-lysylsulfamoyl adenosine Phyre2 PDB 1c0a chain A domain 3 Region: 110 - 314 Aligned: 190 Modelled: 205 Confidence: 99.8% Identity: 20% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain Phyre2 PDB 1nnh chain A Region: 110 - 314 Aligned: 195 Modelled: 205 Confidence: 99.8% Identity: 14% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain Phyre2 PDB 1b8a chain B Region: 110 - 314 Aligned: 189 Modelled: 205 Confidence: 99.8% Identity: 17% PDB header:ligase Chain: B: PDB Molecule:protein (aspartyl-trna synthetase); PDBTitle: aspartyl-trna synthetase Phyre2 PDB 1asy chain A Region: 110 - 314 Aligned: 187 Modelled: 205 Confidence: 99.8% Identity: 20% PDB header:complex (aminoacyl-trna synthase/trna) Chain: A: PDB Molecule:aspartyl-trna synthetase; PDBTitle: class ii aminoacyl transfer rna synthetases: crystal2 structure of yeast aspartyl-trna synthetase complexed with3 trna asp Phyre2 PDB 1x55 chain A Region: 110 - 314 Aligned: 187 Modelled: 203 Confidence: 99.8% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:asparaginyl-trna synthetase; PDBTitle: crystal structure of asparaginyl-trna synthetase from pyrococcus2 horikoshii complexed with asparaginyl-adenylate analogue Phyre2 1 c3pcoC_ 2 c3l4gI_ 3 d1jjca_ 4 c1b70A_ 5 c2du7C_ 6 c2du4B_ 7 c3cmqA_ 8 c2rhqA_ 9 c2zimA_ 10 c2znjB_ 11 c3bjuB_ 12 c1e22A_ 13 c1eqrC_ 14 c1efwA_ 15 c3e9hB_ 16 d1c0aa3 17 d1nnha_ 18 c1b8aB_ 19 c1asyA_ 20 c1x55A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3pcoC_ 100.0 100 PDB header:ligase Chain: C: PDB Molecule:phenylalanyl-trna synthetase, alpha subunit; PDBTitle: crystal structure of e. coli phenylalanine-trna synthetase complexed2 with phenylalanine and amp 2 c3l4gI_ 100.0 35 PDB header:ligase Chain: I: PDB Molecule:phenylalanyl-trna synthetase alpha chain; PDBTitle: crystal structure of homo sapiens cytoplasmic phenylalanyl-trna2 synthetase 3 d1jjca_ 100.0 51 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 4 c1b70A_ 100.0 51 PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase; PDBTitle: phenylalanyl trna synthetase complexed with phenylalanine 5 c2du7C_ 100.0 25 PDB header:ligase Chain: C: PDB Molecule:o-phosphoseryl-trna synthetase; PDBTitle: crystal structure of methanococcus jannacshii o-phosphoseryl-trna2 synthetase 6 c2du4B_ 100.0 24 PDB header:ligase/rna Chain: B: PDB Molecule:o-phosphoseryl-trna synthetase; PDBTitle: crystal structure of archaeoglobus fulgidus o-phosphoseryl-2 trna synthetase complexed with trnacys 7 c3cmqA_ 100.0 36 PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase, mitochondrial; PDBTitle: crystal structure of human mitochondrial phenylalanine trna2 synthetase 8 c2rhqA_ 100.0 56 PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase alpha chain; PDBTitle: phers from staphylococcus haemolyticus- rational protein2 engineering and inhibitor studies 9 c2zimA_ 100.0 19 PDB header:ligase Chain: A: PDB Molecule:pyrrolysyl-trna synthetase; PDBTitle: pyrrolysyl-trna synthetase bound to adenylated pyrrolysine and2 pyrophosphate 10 c2znjB_ 100.0 17 PDB header:ligase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of pyrrolysyl-trna synthetase from2 desulfitobacterium hafniense 11 c3bjuB_ 99.9 21 PDB header:ligase Chain: B: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of tetrameric form of human lysyl-trna2 synthetase 12 c1e22A_ 99.9 20 PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: lysyl-trna synthetase (lysu) hexagonal form complexed with2 lysine and the non-hydrolysable atp analogue amp-pcp 13 c1eqrC_ 99.8 25 PDB header:ligase Chain: C: PDB Molecule:aspartyl-trna synthetase; PDBTitle: crystal structure of free aspartyl-trna synthetase from2 escherichia coli 14 c1efwA_ 99.8 29 PDB header:ligase/rna Chain: A: PDB Molecule:aspartyl-trna synthetase; PDBTitle: crystal structure of aspartyl-trna synthetase from thermus2 thermophilus complexed to trnaasp from escherichia coli 15 c3e9hB_ 99.8 20 PDB header:ligase Chain: B: PDB Molecule:lysyl-trna synthetase; PDBTitle: lysyl-trna synthetase from bacillus stearothermophilus2 complexed with l-lysylsulfamoyl adenosine 16 d1c0aa3 99.8 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 17 d1nnha_ 99.8 14 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 18 c1b8aB_ 99.8 17 PDB header:ligase Chain: B: PDB Molecule:protein (aspartyl-trna synthetase); PDBTitle: aspartyl-trna synthetase 19 c1asyA_ 99.8 20 PDB header:complex (aminoacyl-trna synthase/trna) Chain: A: PDB Molecule:aspartyl-trna synthetase; PDBTitle: class ii aminoacyl transfer rna synthetases: crystal2 structure of yeast aspartyl-trna synthetase complexed with3 trna asp 20 c1x55A_ 99.8 14 PDB header:ligase Chain: A: PDB Molecule:asparaginyl-trna synthetase; PDBTitle: crystal structure of asparaginyl-trna synthetase from pyrococcus2 horikoshii complexed with asparaginyl-adenylate analogue 21 c3icaB_ not modelled 99.8 13 PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: the crystal structure of the beta subunit of a phenylalanyl-trna2 synthetase from porphyromonas gingivalis w83 22 d1l0wa3 not modelled 99.8 24 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 23 c1wydB_ not modelled 99.7 21 PDB header:ligase Chain: B: PDB Molecule:hypothetical aspartyl-trna synthetase; PDBTitle: crystal structure of aspartyl-trna synthetase from sulfolobus tokodaii 24 d1b8aa2 not modelled 99.7 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 25 d1eova2 not modelled 99.7 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 26 d1jjcb5 not modelled 99.7 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 27 c2xgtB_ not modelled 99.7 18 PDB header:ligase Chain: B: PDB Molecule:asparaginyl-trna synthetase, cytoplasmic; PDBTitle: asparaginyl-trna synthetase from brugia malayi complexed2 with the sulphamoyl analogue of asparaginyl-adenylate 28 c3l4gL_ not modelled 99.7 12 PDB header:ligase Chain: L: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: crystal structure of homo sapiens cytoplasmic phenylalanyl-trna2 synthetase 29 c3g1zB_ not modelled 99.7 20 PDB header:ligase Chain: B: PDB Molecule:putative lysyl-trna synthetase; PDBTitle: structure of idp01693/yjea, a potential t-rna synthetase from2 salmonella typhimurium 30 c3i7fA_ not modelled 99.6 24 PDB header:ligase Chain: A: PDB Molecule:aspartyl-trna synthetase; PDBTitle: aspartyl trna synthetase from entamoeba histolytica 31 c3m4qA_ not modelled 99.6 21 PDB header:ligase Chain: A: PDB Molecule:asparaginyl-trna synthetase, putative; PDBTitle: entamoeba histolytica asparaginyl-trna synthetase (asnrs) 32 c3ig2B_ not modelled 99.6 12 PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: the crystal structure of a putative phenylalanyl-trna synthetase2 (phers) beta chain domain from bacteroides fragilis to 2.1a 33 c3pcoD_ not modelled 99.6 18 PDB header:ligase Chain: D: PDB Molecule:phenylalanyl-trna synthetase, beta chain; PDBTitle: crystal structure of e. coli phenylalanine-trna synthetase complexed2 with phenylalanine and amp 34 c2rhsB_ not modelled 99.5 15 PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: phers from staphylococcus haemolyticus- rational protein2 engineering and inhibitor studies 35 d1kmma2 not modelled 99.4 15 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 36 d1e1oa2 not modelled 99.4 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 37 d1bbua2 not modelled 99.3 21 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 38 d1qf6a4 not modelled 99.2 19 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 39 c1fyfB_ not modelled 99.2 19 PDB header:ligase Chain: B: PDB Molecule:threonyl-trna synthetase; PDBTitle: crystal structure of a truncated form of threonyl-trna2 synthetase complexed with a seryl adenylate analog 40 c2akwB_ not modelled 99.2 21 PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: crystal structure of t.thermophilus phenylalanyl-trna synthetase2 complexed with p-cl-phenylalanine 41 d1eiya1 not modelled 99.2 44 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Phenylalanyl-tRNA synthetase (PheRS) 42 c1nyqA_ not modelled 99.2 17 PDB header:ligase Chain: A: PDB Molecule:threonyl-trna synthetase 1; PDBTitle: structure of staphylococcus aureus threonyl-trna synthetase2 complexed with an analogue of threonyl adenylate 43 c1n9wA_ not modelled 99.2 32 PDB header:biosynthetic protein Chain: A: PDB Molecule:aspartyl-trna synthetase 2; PDBTitle: crystal structure of the non-discriminating and archaeal-2 type aspartyl-trna synthetase from thermus thermophilus 44 d1n9wa2 not modelled 99.2 32 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 45 c1z7nB_ not modelled 99.0 11 PDB header:transferase Chain: B: PDB Molecule:atp phosphoribosyltransferase regulatory subunit; PDBTitle: atp phosphoribosyl transferase (hiszg atp-prtase) from2 lactococcus lactis with bound prpp substrate 46 d2iy5a1 not modelled 99.0 43 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Phenylalanyl-tRNA synthetase (PheRS) 47 d1hc7a2 not modelled 99.0 14 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 48 c1qf6A_ not modelled 99.0 17 PDB header:ligase/rna Chain: A: PDB Molecule:threonyl-trna synthetase; PDBTitle: structure of e. coli threonyl-trna synthetase complexed with its2 cognate trna 49 c2dq0A_ not modelled 99.0 15 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of seryl-trna synthetase from pyrococcus2 horikoshii complexed with a seryl-adenylate analog 50 c3qo8A_ not modelled 99.0 16 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of seryl-trna synthetase from candida albicans 51 d1nj8a3 not modelled 98.9 17 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 52 d1seta2 not modelled 98.9 15 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 53 d1wu7a2 not modelled 98.9 16 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 54 c1sryB_ not modelled 98.9 17 PDB header:ligase(synthetase) Chain: B: PDB Molecule:seryl-trna synthetase; PDBTitle: refined crystal structure of the seryl-trna synthetase from2 thermus thermophilus at 2.5 angstroms resolution 55 d1nj1a3 not modelled 98.9 17 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 56 c3racA_ not modelled 98.9 18 PDB header:ligase Chain: A: PDB Molecule:histidine-trna ligase; PDBTitle: crystal strucutre of histidine--trna ligase subunit from2 alicyclobacillus acidocaldarius subsp. acidocaldarius dsm 446. 57 c2dq3A_ not modelled 98.9 14 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of aq_298 58 c1h4tD_ not modelled 98.8 15 PDB header:aminoacyl-trna synthetase Chain: D: PDB Molecule:prolyl-trna synthetase; PDBTitle: prolyl-trna synthetase from thermus thermophilus complexed2 with l-proline 59 c1nj8C_ not modelled 98.8 17 PDB header:ligase Chain: C: PDB Molecule:proline-trna synthetase; PDBTitle: crystal structure of prolyl-trna synthetase from2 methanocaldococcus janaschii 60 c2el9B_ not modelled 98.8 17 PDB header:ligase Chain: B: PDB Molecule:histidyl-trna synthetase; PDBTitle: crystal structure of e.coli histidyl-trna synthetase2 complexed with a histidyl-adenylate analogue 61 c3lssA_ not modelled 98.8 14 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: trypanosoma brucei seryl-trna synthetase in complex with atp 62 c1nj2A_ not modelled 98.8 13 PDB header:ligase Chain: A: PDB Molecule:proline-trna synthetase; PDBTitle: crystal structure of prolyl-trna synthetase from methanothermobacter2 thermautotrophicus 63 d1nyra4 not modelled 98.8 18 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 64 c1atiA_ not modelled 98.7 13 PDB header:protein biosynthesis Chain: A: PDB Molecule:glycyl-trna synthetase; PDBTitle: crystal structure of glycyl-trna synthetase from thermus thermophilus 65 c1adyA_ not modelled 98.7 16 PDB header:trna synthetase Chain: A: PDB Molecule:histidyl-trna synthetase; PDBTitle: histidyl-trna synthetase in complex with histidyl-adenylate 66 c3hriF_ not modelled 98.7 12 PDB header:ligase Chain: F: PDB Molecule:histidyl-trna synthetase; PDBTitle: histidyl-trna synthetase (apo) from trypanosoma brucei 67 c1wleB_ not modelled 98.7 14 PDB header:ligase Chain: B: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of mammalian mitochondrial seryl-trna2 synthetase complexed with seryl-adenylate 68 d1b76a2 not modelled 98.7 9 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 69 d1atia2 not modelled 98.7 9 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 70 c3a32A_ not modelled 98.7 17 PDB header:ligase Chain: A: PDB Molecule:probable threonyl-trna synthetase 1; PDBTitle: crystal structure of putative threonyl-trna synthetase2 thrrs-1 from aeropyrum pernix 71 c1ggmB_ not modelled 98.6 14 PDB header:ligase Chain: B: PDB Molecule:protein (glycyl-trna synthetase); PDBTitle: glycyl-trna synthetase from thermus thermophilus complexed with2 glycyl-adenylate 72 c3mf2B_ not modelled 98.6 11 PDB header:ligase Chain: B: PDB Molecule:bll0957 protein; PDBTitle: crystal structure of class ii aars homologue (bll0957) complexed with2 amp 73 c3ialB_ not modelled 98.6 15 PDB header:ligase Chain: B: PDB Molecule:prolyl-trna synthetase; PDBTitle: giardia lamblia prolyl-trna synthetase in complex with prolyl-2 adenylate 74 c3od1A_ not modelled 98.6 15 PDB header:transferase Chain: A: PDB Molecule:atp phosphoribosyltransferase regulatory subunit; PDBTitle: the crystal structure of an atp phosphoribosyltransferase regulatory2 subunit/histidyl-trna synthetase from bacillus halodurans c 75 c1wu7A_ not modelled 98.6 16 PDB header:ligase Chain: A: PDB Molecule:histidyl-trna synthetase; PDBTitle: crystal structure of histidyl-trna synthetase from2 thermoplasma acidophilum 76 d1h4vb2 not modelled 98.6 15 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 77 c2i4lC_ not modelled 98.6 9 PDB header:ligase Chain: C: PDB Molecule:proline-trna ligase; PDBTitle: rhodopseudomonas palustris prolyl-trna synthetase 78 c1qe0B_ not modelled 98.4 20 PDB header:ligase Chain: B: PDB Molecule:histidyl-trna synthetase; PDBTitle: crystal structure of apo s. aureus histidyl-trna synthetase 79 c3netB_ not modelled 98.4 17 PDB header:ligase Chain: B: PDB Molecule:histidyl-trna synthetase; PDBTitle: crystal structure of histidyl-trna synthetase from nostoc sp. pcc 7120 80 c3errB_ not modelled 98.4 16 PDB header:ligase Chain: B: PDB Molecule:fusion protein of microtubule binding domain from PDBTitle: microtubule binding domain from mouse cytoplasmic dynein as2 a fusion with seryl-trna synthetase 81 c2j3mA_ not modelled 98.3 9 PDB header:ligase Chain: A: PDB Molecule:prolyl-trna synthetase; PDBTitle: prolyl-trna synthetase from enterococcus faecalis complexed2 with atp, manganese and prolinol 82 d1qe0a2 not modelled 98.3 14 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 83 c2cj9A_ not modelled 98.2 13 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of methanosarcina barkeri seryl-trna2 synthetase complexed with an analog of seryladenylate 84 d1z7ma1 not modelled 98.1 12 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 85 d1g5ha2 not modelled 98.1 7 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 86 d2g4ca2 not modelled 98.0 7 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 87 c1g5hA_ not modelled 98.0 7 PDB header:dna binding protein Chain: A: PDB Molecule:mitochondrial dna polymerase accessory subunit; PDBTitle: crystal structure of the accessory subunit of murine mitochondrial2 polymerase gamma 88 d1usya_ not modelled 97.9 15 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 89 c2pmfA_ not modelled 97.7 19 PDB header:ligase Chain: A: PDB Molecule:glycyl-trna synthetase; PDBTitle: the crystal structure of a human glycyl-trna synthetase mutant 90 c3ikmC_ not modelled 97.7 8 PDB header:transferase Chain: C: PDB Molecule:dna polymerase subunit gamma-2; PDBTitle: crystal structure of human mitochondrial dna polymerase2 holoenzyme 91 d1riqa2 not modelled 96.8 20 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 92 c3hxxA_ not modelled 96.7 17 PDB header:ligase Chain: A: PDB Molecule:alanyl-trna synthetase; PDBTitle: crystal structure of catalytic fragment of e. coli alars in complex2 with amppcp 93 c1yfsB_ not modelled 96.6 17 PDB header:ligase Chain: B: PDB Molecule:alanyl-trna synthetase; PDBTitle: the crystal structure of alanyl-trna synthetase in complex2 with l-alanine 94 d1j5wa_ not modelled 96.2 19 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 95 c2ztgA_ not modelled 93.2 15 PDB header:ligase Chain: A: PDB Molecule:alanyl-trna synthetase; PDBTitle: crystal structure of archaeoglobus fulgidus alanyl-trna2 synthetase lacking the c-terminal dimerization domain in3 complex with ala-sa 96 c2zzfA_ not modelled 93.2 19 PDB header:ligase Chain: A: PDB Molecule:alanyl-trna synthetase; PDBTitle: crystal structure of alanyl-trna synthetase without2 oligomerization domain 97 c2phmA_ not modelled 81.5 17 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (phenylalanine-4-hydroxylase); PDBTitle: structure of phenylalanine hydroxylase dephosphorylated 98 d1phza2 not modelled 80.9 17 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 99 d1toha_ not modelled 79.0 17 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 100 d1j8ua_ not modelled 77.9 17 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 101 c3e2tA_ not modelled 76.0 15 PDB header:oxidoreductase Chain: A: PDB Molecule:tryptophan 5-hydroxylase 1; PDBTitle: the catalytic domain of chicken tryptophan hydroxylase 12 with bound tryptophan 102 c3rf1B_ not modelled 70.0 24 PDB header:ligase Chain: B: PDB Molecule:glycyl-trna synthetase alpha subunit; PDBTitle: the crystal structure of glycyl-trna synthetase subunit alpha from2 campylobacter jejuni subsp. jejuni nctc 11168 103 c3ls1A_ not modelled 45.7 15 PDB header:photosynthesis Chain: A: PDB Molecule:sll1638 protein; PDBTitle: crystal structure of cyanobacterial psbq from synechocystis2 sp. pcc 6803 complexed with zn2+ 104 c2lhuA_ not modelled 43.5 53 PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain 105 c1vraA_ not modelled 42.0 56 PDB header:transferase Chain: A: PDB Molecule:arginine biosynthesis bifunctional protein argj; PDBTitle: crystal structure of arginine biosynthesis bifunctional protein argj2 (10175521) from bacillus halodurans at 2.00 a resolution 106 c3it4C_ not modelled 41.4 44 PDB header:transferase Chain: C: PDB Molecule:arginine biosynthesis bifunctional protein argj PDBTitle: the crystal structure of ornithine acetyltransferase from2 mycobacterium tuberculosis (rv1653) at 1.7 a 107 c2v4iA_ not modelled 40.1 44 PDB header:transferase Chain: A: PDB Molecule:glutamate n-acetyltransferase 2 alpha chain; PDBTitle: structure of a novel n-acyl-enzyme intermediate of an n-2 terminal nucleophile (ntn) hydrolase, oat2 108 d12asa_ not modelled 39.1 28 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 109 c3n6oB_ not modelled 38.8 25 PDB header:signaling protein Chain: B: PDB Molecule:guanine nucleotide exchange factor; PDBTitle: crystal structure of the gef and p4m domain of drra/sidm from2 legionella pneumophila 110 d1uoya_ not modelled 36.9 60 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Bubble protein Family:Bubble protein 111 d1h05a_ not modelled 31.4 18 Fold:Flavodoxin-like Superfamily:Type II 3-dehydroquinate dehydratase Family:Type II 3-dehydroquinate dehydratase 112 d1vz6a_ not modelled 31.2 44 Fold:DmpA/ArgJ-like Superfamily:DmpA/ArgJ-like Family:ArgJ-like 113 d1vr3a1 not modelled 23.0 25 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:Acireductone dioxygenase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0