Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	L	Y	N	L	K	D	H	N	E	Q	V	S	F	A	Q	A	V	T	Q	G	L	G	K	N	Q	G	L	F	F	P	H	D	L	P	E	F	S	L	T	E	I	D	E	M	L	K	L	D	F	V	T	R	S	A	K	I	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	F	I	G	D	E	I	P	Q	E	I	L	E	E	R	V	R	A	A	F	A	F	P	A	P	V	A	N	V	E	S	D	V	G	C	L	E	L	F	H	G	P	T	L	A	F	K	D	F	G	G	R	F	M	A	Q	M	L	T	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	A	G	D	K	P	V	T	I	L	T	A	T	S	G	D	T	G	A	A	V	A	H	A	F	Y	G	L	P	N	V	K	V	V	I	L	Y	P	R	G	K	I	S	P	L	Q	E	K	L	F	C	T	L	G	G	N	I	E	T	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	I	D	G	D	F	D	A	C	Q	A	L	V	K	Q	A	F	D	D	E	E	L	K	V	A	L	G	L	N	S	A	N	S	I	N	I	S	R	L	L	A	Q	I	C	Y	Y	F	E	A	V	A	Q	L	P	Q	E	T	R	N	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	V	V	S	V	P	S	G	N	F	G	D	L	T	A	G	L	L	A	K	S	L	G	L	P	V	K	R	F	I	A	A	T	N	V	N	D	T	V	P	R	F	L	H	D	G	Q	W	S	P	K	A	T	Q	A	T	L	S	N	A
Secondary structure
SS confidence
Disorder																																																	?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		M	D	V	S	Q	P	N	N	W	P	R	V	E	E	L	F	R	R	K	I	W	Q	L	K	E	L	G	Y	A	A	V	D	D	E	T	T	Q	Q	T	M	R	E	L	K	E	L	G	Y	T	S	E	P	H	A	A	V	A	Y	R	A
Secondary structure
SS confidence
Disorder			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	R	D	Q	L	N	P	G	E	Y	G	L	F	L	G	T	A	H	P	A	K	F	K	E	S	V	E	A	I	L	G	E	T	L	D	L	P	K	E	L	A	E	R	A	D	L	P	L	L	S	H	N	L	P	A	D	F	A	A	L
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		R	K	L	M	M	N	H	Q
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1vb3 chain A domain 1 Region: 1 - 428 Aligned: 428 Modelled: 428 Confidence: 100.0% Identity: 100% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1kl7 chain A Region: 1 - 427 Aligned: 425 Modelled: 427 Confidence: 100.0% Identity: 35% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3v7n chain A Region: 2 - 427 Aligned: 425 Modelled: 426 Confidence: 100.0% Identity: 28% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis Phyre2 PDB 1e5x chain A Region: 1 - 427 Aligned: 386 Modelled: 408 Confidence: 100.0% Identity: 23% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1v8z chain A domain 1 Region: 25 - 391 Aligned: 341 Modelled: 350 Confidence: 100.0% Identity: 18% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2d1f chain A Region: 82 - 406 Aligned: 301 Modelled: 322 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase Phyre2 PDB 1v7c chain A Region: 83 - 405 Aligned: 297 Modelled: 323 Confidence: 100.0% Identity: 24% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2zsj chain B Region: 83 - 405 Aligned: 297 Modelled: 314 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 Phyre2 PDB 1qop chain B Region: 19 - 390 Aligned: 347 Modelled: 372 Confidence: 100.0% Identity: 15% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1pwh chain A Region: 82 - 390 Aligned: 287 Modelled: 309 Confidence: 100.0% Identity: 14% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1tdj chain A Region: 83 - 377 Aligned: 273 Modelled: 293 Confidence: 100.0% Identity: 17% PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli Phyre2 PDB 2rkb chain E Region: 84 - 390 Aligned: 284 Modelled: 304 Confidence: 100.0% Identity: 14% PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells Phyre2 PDB 1x1q chain A Region: 27 - 392 Aligned: 342 Modelled: 366 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 Phyre2 PDB 2gn0 chain A Region: 67 - 391 Aligned: 301 Modelled: 325 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) Phyre2 PDB 3r0z chain A Region: 83 - 392 Aligned: 291 Modelled: 310 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium Phyre2 PDB 1v71 chain A domain 1 Region: 82 - 392 Aligned: 287 Modelled: 311 Confidence: 100.0% Identity: 17% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3l6c chain A Region: 66 - 386 Aligned: 299 Modelled: 321 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor Phyre2 PDB 1p5j chain A Region: 80 - 390 Aligned: 289 Modelled: 311 Confidence: 100.0% Identity: 14% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1p5j chain A Region: 80 - 390 Aligned: 289 Modelled: 311 Confidence: 100.0% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase Phyre2 PDB 1tdj chain A domain 1 Region: 61 - 377 Aligned: 295 Modelled: 313 Confidence: 100.0% Identity: 19% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 1 d1vb3a1 2 d1kl7a_ 3 c3v7nA_ 4 d1e5xa_ 5 d1v8za1 6 c2d1fA_ 7 d1v7ca_ 8 c2zsjB_ 9 d1qopb_ 10 d1pwha_ 11 c1tdjA_ 12 c2rkbE_ 13 c1x1qA_ 14 c2gn0A_ 15 c3r0zA_ 16 d1v71a1 17 c3l6cA_ 18 d1p5ja_ 19 c1p5jA_ 20 d1tdja1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1vb3a1 100.0 100 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 2 d1kl7a_ 100.0 35 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 3 c3v7nA_ 100.0 28 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis 4 d1e5xa_ 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 5 d1v8za1 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 6 c2d1fA_ 100.0 23 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase 7 d1v7ca_ 100.0 24 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 8 c2zsjB_ 100.0 20 PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 9 d1qopb_ 100.0 15 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 10 d1pwha_ 100.0 14 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 11 c1tdjA_ 100.0 17 PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli 12 c2rkbE_ 100.0 14 PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells 13 c1x1qA_ 100.0 17 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 14 c2gn0A_ 100.0 16 PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) 15 c3r0zA_ 100.0 16 PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium 16 d1v71a1 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 17 c3l6cA_ 100.0 16 PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor 18 d1p5ja_ 100.0 14 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 19 c1p5jA_ 100.0 14 PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase 20 d1tdja1 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 21 d1y7la1 not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 22 d1wkva1 not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 23 d1ve5a1 not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 24 c3iauA_ not modelled 100.0 16 PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum 25 d1ve1a1 not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 26 d1jbqa_ not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 27 c1jbqD_ not modelled 100.0 18 PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein 28 c3pc3A_ not modelled 100.0 19 PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate 29 d2bhsa1 not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 30 d1z7wa1 not modelled 100.0 15 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 31 d1o58a_ not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 32 c3dwgA_ not modelled 100.0 18 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis 33 d1fcja_ not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 34 c2pqmA_ not modelled 100.0 14 PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution 35 c2q3bA_ not modelled 100.0 16 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis 36 c2o2jA_ not modelled 100.0 16 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: mycobacterium tuberculosis tryptophan synthase beta chain2 dimer (apoform) 37 c2eguA_ not modelled 100.0 21 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 38 d1f2da_ not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 39 d1tyza_ not modelled 100.0 13 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 40 d1j0aa_ not modelled 100.0 13 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 41 c2qx7A_ not modelled 80.8 18 PDB header:plant protein Chain: A: PDB Molecule:eugenol synthase 1; PDBTitle: structure of eugenol synthase from ocimum basilicum 42 d1vp8a_ not modelled 80.8 17 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 43 d1xgka_ not modelled 79.4 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 44 d1qsga_ not modelled 77.8 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 45 c3s8mA_ not modelled 72.4 9 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 46 d1t57a_ not modelled 69.0 16 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 47 c2uv8C_ not modelled 68.8 17 PDB header:transferase Chain: C: PDB Molecule:fatty acid synthase subunit alpha (fas2); PDBTitle: crystal structure of yeast fatty acid synthase with stalled2 acyl carrier protein at 3.1 angstrom resolution 48 d1o8ca2 not modelled 64.9 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 49 c3imfA_ not modelled 63.5 18 PDB header:oxidoreductase Chain: A: PDB Molecule:short chain dehydrogenase; PDBTitle: 1.99 angstrom resolution crystal structure of a short chain2 dehydrogenase from bacillus anthracis str. 'ames ancestor' 50 d1ecfa1 not modelled 63.2 19 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 51 d1gph11 not modelled 61.0 18 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 52 c3iccA_ not modelled 59.8 18 PDB header:oxidoreductase Chain: A: PDB Molecule:putative 3-oxoacyl-(acyl carrier protein) reductase; PDBTitle: crystal structure of a putative 3-oxoacyl-(acyl carrier protein)2 reductase from bacillus anthracis at 1.87 a resolution 53 c2q2qG_ not modelled 58.5 10 PDB header:oxidoreductase Chain: G: PDB Molecule:beta-d-hydroxybutyrate dehydrogenase; PDBTitle: structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida 54 c1m6yA_ not modelled 58.2 12 PDB header:transferase Chain: A: PDB Molecule:s-adenosyl-methyltransferase mraw; PDBTitle: crystal structure analysis of tm0872, a putative sam-2 dependent methyltransferase, complexed with sah 55 c3ek2D_ not modelled 57.8 13 PDB header:oxidoreductase Chain: D: PDB Molecule:enoyl-(acyl-carrier-protein) reductase (nadh); PDBTitle: crystal structure of eonyl-(acyl carrier protein) reductase2 from burkholderia pseudomallei 1719b 56 c2vkzC_ not modelled 57.7 17 PDB header:transferase Chain: C: PDB Molecule:fatty acid synthase subunit alpha; PDBTitle: structure of the cerulenin-inhibited fungal fatty acid2 synthase type i multienzyme complex 57 c2rgwD_ not modelled 55.8 16 PDB header:transferase Chain: D: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: catalytic subunit of m. jannaschii aspartate2 transcarbamoylase 58 d1ae1a_ not modelled 54.7 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 59 d1q59a_ not modelled 52.9 11 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 60 c2p2gD_ not modelled 50.8 17 PDB header:transferase Chain: D: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase from mycobacterium2 tuberculosis (rv1656): orthorhombic form 61 c3qvoA_ not modelled 47.0 9 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:nmra family protein; PDBTitle: structure of a rossmann-fold nad(p)-binding family protein from2 shigella flexneri. 62 c3ezlA_ not modelled 46.8 12 PDB header:oxidoreductase Chain: A: PDB Molecule:acetoacetyl-coa reductase; PDBTitle: crystal structure of acetyacetyl-coa reductase from2 burkholderia pseudomallei 1710b 63 c1stzB_ not modelled 45.4 28 PDB header:transcription Chain: B: PDB Molecule:heat-inducible transcription repressor hrca homolog; PDBTitle: crystal structure of a hypothetical protein at 2.2 a resolution 64 c1gph1_ not modelled 45.4 18 PDB header:transferase(glutamine amidotransferase) Chain: 1: PDB Molecule:glutamine phosphoribosyl-pyrophosphate amidotransferase; PDBTitle: structure of the allosteric regulatory enzyme of purine biosynthesis 65 d2ax3a2 not modelled 43.5 12 Fold:YjeF N-terminal domain-like Superfamily:YjeF N-terminal domain-like Family:YjeF N-terminal domain-like 66 c2qkmF_ not modelled 43.4 23 PDB header:hydrolase Chain: F: PDB Molecule:spac19a8.12 protein; PDBTitle: the crystal structure of fission yeast mrna decapping enzyme dcp1-dcp22 complex 67 d2qklb1 not modelled 43.3 23 Fold:Dcp2 domain-like Superfamily:Dcp2 domain-like Family:Dcp2 box A domain 68 c3kb8A_ not modelled 43.2 13 PDB header:transferase Chain: A: PDB Molecule:hypoxanthine phosphoribosyltransferase; PDBTitle: 2.09 angstrom resolution structure of a hypoxanthine-guanine2 phosphoribosyltransferase (hpt-1) from bacillus anthracis str. 'ames3 ancestor' in complex with gmp 69 c3toxG_ not modelled 43.2 17 PDB header:oxidoreductase Chain: G: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a short chain dehydrogenase in complex with2 nad(p) from sinorhizobium meliloti 1021 70 c3qp9C_ not modelled 43.1 15 PDB header:oxidoreductase Chain: C: PDB Molecule:type i polyketide synthase pikaii; PDBTitle: the structure of a c2-type ketoreductase from a modular polyketide2 synthase 71 d1pq1a_ not modelled 41.9 14 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 72 c3d3jA_ not modelled 41.5 20 PDB header:protein binding Chain: A: PDB Molecule:enhancer of mrna-decapping protein 3; PDBTitle: crystal structure of human edc3p 73 c3grkE_ not modelled 41.2 13 PDB header:oxidoreductase Chain: E: PDB Molecule:enoyl-(acyl-carrier-protein) reductase (nadh); PDBTitle: crystal structure of short chain dehydrogenase reductase2 sdr glucose-ribitol dehydrogenase from brucella melitensis 74 c2vzkD_ not modelled 40.9 20 PDB header:transferase Chain: D: PDB Molecule:glutamate n-acetyltransferase 2 beta chain; PDBTitle: structure of the acyl-enzyme complex of an n-terminal2 nucleophile (ntn) hydrolase, oat2 75 d1qyda_ not modelled 39.5 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 76 c3ijrF_ not modelled 37.8 16 PDB header:oxidoreductase Chain: F: PDB Molecule:oxidoreductase, short chain dehydrogenase/reductase family; PDBTitle: 2.05 angstrom resolution crystal structure of a short chain2 dehydrogenase from bacillus anthracis str. 'ames ancestor' in complex3 with nad+ 77 c2vofA_ not modelled 37.6 25 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain 78 c3i5mA_ not modelled 37.5 24 PDB header:oxidoreductase Chain: A: PDB Molecule:putative leucoanthocyanidin reductase 1; PDBTitle: structure of the apo form of leucoanthocyanidin reductase from vitis2 vinifera 79 d1yfza1 not modelled 36.9 13 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 80 c1yfzA_ not modelled 36.9 13 PDB header:transferase Chain: A: PDB Molecule:hypoxanthine-guanine phosphoribosyltransferase; PDBTitle: novel imp binding in feedback inhibition of hypoxanthine-guanine2 phosphoribosyltransferase from thermoanaerobacter tengcongensis 81 d1a1va1 not modelled 36.7 15 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:RNA helicase 82 c3e59A_ not modelled 36.5 24 PDB header:transferase Chain: A: PDB Molecule:pyoverdine biosynthesis protein pvca; PDBTitle: crystal structure of the pvca (pa2254) protein from pseudomonas2 aeruginosa 83 d1fw8a_ not modelled 36.0 19 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 84 c3gdfA_ not modelled 35.8 21 PDB header:oxidoreductase Chain: A: PDB Molecule:probable nadp-dependent mannitol dehydrogenase; PDBTitle: crystal structure of the nadp-dependent mannitol dehydrogenase from2 cladosporium herbarum. 85 c1vraB_ not modelled 35.1 22 PDB header:transferase Chain: B: PDB Molecule:arginine biosynthesis bifunctional protein argj; PDBTitle: crystal structure of arginine biosynthesis bifunctional protein argj2 (10175521) from bacillus halodurans at 2.00 a resolution 86 c3v8bC_ not modelled 34.8 15 PDB header:oxidoreductase Chain: C: PDB Molecule:putative dehydrogenase, possibly 3-oxoacyl-[acyl-carrier PDBTitle: crystal structure of a 3-ketoacyl-acp reductase from sinorhizobium2 meliloti 1021 87 c3ppiA_ not modelled 34.7 20 PDB header:oxidoreductase Chain: A: PDB Molecule:3-hydroxyacyl-coa dehydrogenase type-2; PDBTitle: crystal structure of 3-hydroxyacyl-coa dehydrogenase type-2 from2 mycobacterium avium 88 c1oi7A_ not modelled 34.5 12 PDB header:synthetase Chain: A: PDB Molecule:succinyl-coa synthetase alpha chain; PDBTitle: the crystal structure of succinyl-coa synthetase alpha2 subunit from thermus thermophilus 89 c3oidA_ not modelled 34.5 18 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-[acyl-carrier-protein] reductase [nadph]; PDBTitle: crystal structure of enoyl-acp reductases iii (fabl) from b. subtilis2 (complex with nadp and tcl) 90 d1p9oa_ not modelled 34.3 35 Fold:Ribokinase-like Superfamily:CoaB-like Family:CoaB-like 91 d2rhca1 not modelled 33.7 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 92 c2gn9B_ not modelled 33.3 11 PDB header:lyase Chain: B: PDB Molecule:udp-glcnac c6 dehydratase; PDBTitle: crystal structure of udp-glcnac inverting 4,6-dehydratase in complex2 with nadp and udp-glc 93 c3it4B_ not modelled 33.3 32 PDB header:transferase Chain: B: PDB Molecule:arginine biosynthesis bifunctional protein argj PDBTitle: the crystal structure of ornithine acetyltransferase from2 mycobacterium tuberculosis (rv1653) at 1.7 a 94 d1trba1 not modelled 32.8 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 95 c3cxtA_ not modelled 32.7 15 PDB header:oxidoreductase Chain: A: PDB Molecule:dehydrogenase with different specificities; PDBTitle: quaternary complex structure of gluconate 5-dehydrogenase from2 streptococcus suis type 2 96 c2zatC_ not modelled 32.5 12 PDB header:oxidoreductase Chain: C: PDB Molecule:dehydrogenase/reductase sdr family member 4; PDBTitle: crystal structure of a mammalian reductase 97 d1uana_ not modelled 32.3 23 Fold:LmbE-like Superfamily:LmbE-like Family:LmbE-like 98 c3bmrA_ not modelled 32.0 17 PDB header:oxidoreductase Chain: A: PDB Molecule:pteridine reductase; PDBTitle: structure of pteridine reductase 1 (ptr1) from trypanosoma2 brucei in ternary complex with cofactor (nadp+) and3 inhibitor (compound ax6) 99 d1f16a_ not modelled 32.0 15 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 100 c2gk4A_ not modelled 31.9 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: the crystal structure of the dna/pantothenate metabolism flavoprotein2 from streptococcus pneumoniae 101 c2yv6A_ not modelled 31.2 17 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2 homologous antagonist/killer; PDBTitle: crystal structure of human bcl-2 family protein bak 102 d2gnoa2 not modelled 30.8 15 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Extended AAA-ATPase domain 103 d2gdza1 not modelled 30.2 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 104 d1bxla_ not modelled 30.0 15 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 105 d1xdpa3 not modelled 29.8 14 Fold:Phospholipase D/nuclease Superfamily:Phospholipase D/nuclease Family:Polyphosphate kinase C-terminal domain 106 c3ioyB_ not modelled 29.4 13 PDB header:oxidoreductase Chain: B: PDB Molecule:short-chain dehydrogenase/reductase sdr; PDBTitle: structure of putative short-chain dehydrogenase (saro_0793)2 from novosphingobium aromaticivorans 107 c3dfmA_ not modelled 29.2 19 PDB header:hydrolase Chain: A: PDB Molecule:teicoplanin pseudoaglycone deacetylase orf2; PDBTitle: the crystal structure of the zinc inhibited form of2 teicoplanin deacetylase orf2 108 d1hgxa_ not modelled 29.0 18 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 109 c1n7gB_ not modelled 28.9 12 PDB header:lyase Chain: B: PDB Molecule:gdp-d-mannose-4,6-dehydratase; PDBTitle: crystal structure of the gdp-mannose 4,6-dehydratase2 ternary complex with nadph and gdp-rhamnose. 110 d1hdia_ not modelled 28.9 21 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 111 c1w4zA_ not modelled 28.8 14 PDB header:antibiotic biosynthesis Chain: A: PDB Molecule:ketoacyl reductase; PDBTitle: structure of actinorhodin polyketide (actiii) reductase 112 c2qioA_ not modelled 28.6 13 PDB header:unknown function Chain: A: PDB Molecule:enoyl-(acyl-carrier-protein) reductase; PDBTitle: x-ray structure of enoyl-acyl carrier protein reductase from bacillus2 anthracis with triclosan 113 d1vz6a_ not modelled 28.2 20 Fold:DmpA/ArgJ-like Superfamily:DmpA/ArgJ-like Family:ArgJ-like 114 c3c7cB_ not modelled 27.9 13 PDB header:oxidoreductase Chain: B: PDB Molecule:octopine dehydrogenase; PDBTitle: a structural basis for substrate and stereo selectivity in2 octopine dehydrogenase (odh-nadh-l-arginine) 115 c3dfiA_ not modelled 27.8 19 PDB header:hydrolase Chain: A: PDB Molecule:pseudoaglycone deacetylase dbv21; PDBTitle: the crystal structure of antimicrobial reagent a40926 pseudoaglycone2 deacetylase dbv21 116 c3lxmC_ not modelled 27.6 13 PDB header:transferase Chain: C: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: 2.00 angstrom resolution crystal structure of a catalytic2 subunit of an aspartate carbamoyltransferase (pyrb) from3 yersinia pestis co92 117 c3r3sD_ not modelled 27.6 15 PDB header:oxidoreductase Chain: D: PDB Molecule:oxidoreductase; PDBTitle: structure of the ygha oxidoreductase from salmonella enterica 118 d1mxha_ not modelled 27.1 18 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 119 d1ysga1 not modelled 26.9 14 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 120 d1k3ka_ not modelled 26.8 24 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0