Phyre 2 Results for P00954

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Email | l.a.kelley@imperial.ac.uk
Description | P00954
Date | Thu Jan 5 10:57:18 GMT 2012
Unique Job ID | 3a8c8c7d76345cfa

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c3n9iA_
Top template information
PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92
Confidence and coverage
Confidence: | 100.0% | Coverage: | 99%
332 residues ( 99% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | T | K | P | I | V | F | S | G | A | Q | P | S | G | E | L | T | I | G | N | Y | M | G | A | L | R | Q | W | V | N | M | Q | D | D | Y | H | C | I | Y | C | I | V | D | Q | H | A | I | T | V | R | Q | D | A | Q | K | L | R | K | A | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | L | D | T | L | A | L | Y | L | A | C | G | I | D | P | E | K | S | T | I | F | V | Q | S | H | V | P | E | H | A | Q | L | G | W | A | L | N | C | Y | T | Y | F | G | E | L | S | R | M | T | Q | F | K | D | K | S | A | R | Y | A | E | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | I | N | A | G | L | F | D | Y | P | V | L | M | A | A | D | I | L | L | Y | Q | T | N | L | V | P | V | G | E | D | Q | K | Q | H | L | E | L | S | R | D | I | A | Q | R | F | N | A | L | Y | G | E | I | F | K | V | P | E | P | F | I | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | K | S | G | A | R | V | M | S | L | L | E | P | T | K | K | M | S | K | S | D | D | N | R | N | N | V | I | G | L | L | E | D | P | K | S | V | V | K | K | I | K | R | A | V | T | D | S | D | E | P | P | V | V | R | Y | D | V | Q | N | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | A | G | V | S | N | L | L | D | I | L | S | A | V | T | G | Q | S | I | P | E | L | E | K | Q | F | E | G | K | M | Y | G | H | L | K | G | E | V | A | D | A | V | S | G | M | L | T | E | L | Q | E | R | Y | H | R | F | R | N | D | E | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | .
Sequence |  | F | L | Q | Q | V | M | K | D | G | A | E | K | A | S | A | H | A | S | R | T | L | K | A | V | Y | E | A | I | G | F | V | A | K | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c3n9iA_ |

### PDB 3n9i chain A

Region: 3 - 334
Aligned: 332
Modelled: 332
Confidence: 100.0%
Identity: 86%
PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92

Phyre2
2 |
| c3sz3A_ |

### PDB 3sz3 chain A

Region: 1 - 334
Aligned: 334
Modelled: 334
Confidence: 100.0%
Identity: 68%
PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan

Phyre2
3 |
| d1i6la_ |

### PDB 1i6l chain A

Region: 4 - 332
Aligned: 325
Modelled: 329
Confidence: 100.0%
Identity: 56%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2
4 |
| c3prhB_ |

### PDB 3prh chain B

Region: 3 - 332
Aligned: 309
Modelled: 316
Confidence: 100.0%
Identity: 54%
PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis

Phyre2
5 |
| c2yy5C_ |

### PDB 2yy5 chain C

Region: 4 - 334
Aligned: 324
Modelled: 331
Confidence: 100.0%
Identity: 40%
PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae

Phyre2
6 |
| c1yi8C_ |

### PDB 1yi8 chain C

Region: 2 - 333
Aligned: 326
Modelled: 332
Confidence: 100.0%
Identity: 30%
PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp

Phyre2
7 |
| c3m5wB_ |

### PDB 3m5w chain B

Region: 3 - 330
Aligned: 318
Modelled: 323
Confidence: 100.0%
Identity: 36%
PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni

Phyre2
8 |
| c2el7A_ |

### PDB 2el7 chain A

Region: 4 - 333
Aligned: 310
Modelled: 316
Confidence: 100.0%
Identity: 41%
PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus

Phyre2
9 |
| c2g36A_ |

### PDB 2g36 chain A

Region: 5 - 331
Aligned: 313
Modelled: 324
Confidence: 100.0%
Identity: 35%
PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution

Phyre2
10 |
| c2cycB_ |

### PDB 2cyc chain B

Region: 2 - 305
Aligned: 302
Modelled: 304
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: B: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii

Phyre2
11 |
| c2cybA_ |

### PDB 2cyb chain A

Region: 2 - 292
Aligned: 277
Modelled: 288
Confidence: 100.0%
Identity: 22%
PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus

Phyre2
12 |
| c3a05A_ |

### PDB 3a05 chain A

Region: 2 - 297
Aligned: 277
Modelled: 284
Confidence: 100.0%
Identity: 22%
PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan

Phyre2
13 |
| c2quiB_ |

### PDB 2qui chain B

Region: 2 - 298
Aligned: 281
Modelled: 292
Confidence: 100.0%
Identity: 18%
PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp

Phyre2
14 |
| c3jxeB_ |

### PDB 3jxe chain B

Region: 2 - 323
Aligned: 286
Modelled: 299
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp

Phyre2
15 |
| c3p0jD_ |

### PDB 3p0j chain D

Region: 2 - 307
Aligned: 296
Modelled: 298
Confidence: 100.0%
Identity: 18%
PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1

Phyre2
16 |
| c2cyaA_ |

### PDB 2cya chain A

Region: 2 - 305
Aligned: 280
Modelled: 294
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix

Phyre2
17 |
| c3focB_ |

### PDB 3foc chain B

Region: 2 - 298
Aligned: 280
Modelled: 297
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from giardia lamblia

Phyre2
18 |
| c3hzrD_ |

### PDB 3hzr chain D

Region: 2 - 298
Aligned: 278
Modelled: 297
Confidence: 100.0%
Identity: 18%
PDB header:ligase
Chain: D: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica

Phyre2
19 |
| c2j5bA_ |

### PDB 2j5b chain A

Region: 2 - 307
Aligned: 274
Modelled: 290
Confidence: 100.0%
Identity: 22%
PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol

Phyre2
20 |
| d1r6ta2 |

### PDB 1r6t chain A domain 2

Region: 2 - 298
Aligned: 281
Modelled: 292
Confidence: 100.0%
Identity: 18%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c3n9iA_ |
|  | 100.0 | 86 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92
2 | c3sz3A_ |
|  | 100.0 | 68 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan
3 | d1i6la_ |
|  | 100.0 | 56 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
4 | c3prhB_ |
|  | 100.0 | 54 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis
5 | c2yy5C_ |
|  | 100.0 | 40 | PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae
6 | c1yi8C_ |
|  | 100.0 | 30 | PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp
7 | c3m5wB_ |
|  | 100.0 | 36 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni
8 | c2el7A_ |
|  | 100.0 | 41 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus
9 | c2g36A_ |
|  | 100.0 | 35 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution
10 | c2cycB_ |
|  | 100.0 | 20 | PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii
11 | c2cybA_ |
|  | 100.0 | 22 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus
12 | c3a05A_ |
|  | 100.0 | 22 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan
13 | c2quiB_ |
|  | 100.0 | 18 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp
14 | c3jxeB_ |
|  | 100.0 | 20 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp
15 | c3p0jD_ |
|  | 100.0 | 18 | PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1
16 | c2cyaA_ |
|  | 100.0 | 20 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix
17 | c3focB_ |
|  | 100.0 | 20 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from giardia lamblia
18 | c3hzrD_ |
|  | 100.0 | 18 | PDB header:ligase Chain: D: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica
19 | c2j5bA_ |
|  | 100.0 | 22 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol
20 | d1r6ta2 |
|  | 100.0 | 18 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
21 | c2dlcX_ |
| not modelled | 100.0 | 20 | PDB header:ligase/trna Chain: X: PDB Molecule:tyrosyl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of the ternary complex of yeast tyrosyl-trna2 synthetase
22 | c1q11A_ |
| not modelled | 100.0 | 17 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tyrosyl-trna2 synthetase with tyrosinol
23 | d1n3la_ |
| not modelled | 100.0 | 18 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
24 | c2ip1A_ |
| not modelled | 100.0 | 15 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure analysis of s. cerevisiae tryptophanyl trna2 synthetase
25 | c1r6uB_ |
| not modelled | 100.0 | 15 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity
26 | c3hv0A_ |
| not modelled | 100.0 | 19 | PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from cryptosporidium parvum
27 | d2ts1a_ |
| not modelled | 100.0 | 15 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
28 | c2ts1A_ |
| not modelled | 100.0 | 15 | PDB header:ligase (synthetase) Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate
29 | d1j1ua_ |
| not modelled | 100.0 | 20 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
30 | c1jiiA_ |
| not modelled | 100.0 | 16 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383
31 | d1jila_ |
| not modelled | 100.0 | 16 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
32 | c1x8xA_ |
| not modelled | 100.0 | 15 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine
33 | c3i05B_ |
| not modelled | 100.0 | 21 | PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from trypanosoma brucei
34 | c2rkjM_ |
| not modelled | 100.0 | 15 | PDB header:ligase/rna Chain: M: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing2 factor with a group i intron rna
35 | d1h3fa1 |
| not modelled | 100.0 | 23 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
36 | c1h3eA_ |
| not modelled | 100.0 | 21 | PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed2 with wild-type trnatyr(gua) and with atp and tyrosinol
37 | c2janD_ |
| not modelled | 100.0 | 16 | PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state
38 | c2pidB_ |
| not modelled | 100.0 | 15 | PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog
39 | c3tqoA_ |
| not modelled | 98.7 | 13 | PDB header:ligase Chain: A: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii.
40 | c2x1lC_ |
| not modelled | 98.7 | 19 | PDB header:ligase Chain: C: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine
41 | c2cfoA_ |
| not modelled | 98.5 | 26 | PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu
42 | c2ct8A_ |
| not modelled | 98.5 | 17 | PDB header:ligase/rna Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue
43 | d1li5a2 |
| not modelled | 98.4 | 16 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
44 | c1u0bB_ |
| not modelled | 98.4 | 20 | PDB header:ligase/rna Chain: B: PDB Molecule:cysteinyl trna; PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys
45 | c3afhA_ |
| not modelled | 98.4 | 20 | PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 2; PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog
46 | d1gtra2 |
| not modelled | 98.4 | 16 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
47 | c1g59A_ |
| not modelled | 98.3 | 21 | PDB header:ligase/rna Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: glutamyl-trna synthetase complexed with trna(glu).
48 | d1pfva2 |
| not modelled | 98.3 | 17 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
49 | c3al0C_ |
| not modelled | 98.2 | 19 | PDB header:ligase/rna Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl- PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state.
50 | d1nzja_ |
| not modelled | 98.2 | 22 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
51 | c2o5rA_ |
| not modelled | 98.1 | 17 | PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 1; PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution
52 | d1f7ua2 |
| not modelled | 98.1 | 15 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
53 | d1ivsa4 |
| not modelled | 98.0 | 18 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
54 | d1ffya3 |
| not modelled | 98.0 | 23 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
55 | d1j09a2 |
| not modelled | 98.0 | 20 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
56 | c2ja2A_ |
| not modelled | 98.0 | 28 | PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase
57 | c3aiiA_ |
| not modelled | 97.9 | 20 | PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus
58 | c3c8zB_ |
| not modelled | 97.9 | 14 | PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway
59 | c3sp1B_ |
| not modelled | 97.9 | 14 | PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi
60 | c2hz7A_ |
| not modelled | 97.7 | 12 | PDB header:ligase Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans
61 | c3fnrA_ |
| not modelled | 97.7 | 15 | PDB header:transferase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni;
62 | c1exdA_ |
| not modelled | 97.7 | 14 | PDB header:ligase/rna Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase
63 | c1rqgA_ |
| not modelled | 97.4 | 10 | PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from pyrococcus abyssi
64 | d1rqga2 |
| not modelled | 97.2 | 11 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
65 | c1woyA_ |
| not modelled | 97.1 | 13 | PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus
66 | d1irxa2 |
| not modelled | 96.9 | 20 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
67 | d2d5ba2 |
| not modelled | 96.9 | 12 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
68 | c1pfuA_ |
| not modelled | 96.7 | 13 | PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate
69 | c1irxA_ |
| not modelled | 96.7 | 28 | PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of class i lysyl-trna synthetase
70 | c3kflA_ |
| not modelled | 96.5 | 12 | PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate
71 | d1h3na3 |
| not modelled | 96.4 | 13 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
72 | c1obhA_ |
| not modelled | 95.6 | 15 | PDB header:synthetase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site
73 | c1gaxB_ |
| not modelled | 95.3 | 15 | PDB header:ligase/rna Chain: B: PDB Molecule:valyl-trna synthetase; PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue
74 | c1wkbA_ |
| not modelled | 94.8 | 22 | PDB header:ligase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation
75 | c1qu2A_ |
| not modelled | 94.6 | 28 | PDB header:ligase/rna Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin
76 | d1ilea3 |
| not modelled | 94.2 | 21 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
77 | c1ileA_ |
| not modelled | 93.6 | 18 | PDB header:aminoacyl-trna synthetase Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: isoleucyl-trna synthetase
78 | d1iq0a2 |
| not modelled | 93.4 | 11 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
79 | c2zufA_ |
| not modelled | 93.2 | 21 | PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg)
80 | c1wz2B_ |
| not modelled | 90.9 | 24 | PDB header:ligase/rna Chain: B: PDB Molecule:leucyl-trna synthetase; PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex
81 | c1f7uA_ |
| not modelled | 90.6 | 14 | PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg
82 | c1iq0A_ |
| not modelled | 89.1 | 12 | PDB header:ligase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: thermus thermophilus arginyl-trna synthetase
83 | c2r5wA_ |
| not modelled | 83.6 | 17 | PDB header:hydrolase, transferase Chain: A: PDB Molecule:nicotinamide-nucleotide adenylyltransferase; PDBTitle: crystal structure of a bifunctional nmn2 adenylyltransferase/adp ribose pyrophosphatase from3 francisella tularensis
84 | c1zuwA_ |
| not modelled | 72.2 | 19 | PDB header:isomerase Chain: A: PDB Molecule:glutamate racemase 1; PDBTitle: crystal structure of b.subtilis glutamate racemase (race) with d-glu
85 | c3e27B_ |
| not modelled | 71.6 | 9 | PDB header:transferase Chain: B: PDB Molecule:nicotinate (nicotinamide) nucleotide PDBTitle: nicotinic acid mononucleotide (namn) adenylyltransferase2 from bacillus anthracis: product complex
86 | c2ejcA_ |
| not modelled | 62.0 | 17 | PDB header:ligase Chain: A: PDB Molecule:pantoate--beta-alanine ligase; PDBTitle: crystal structure of pantoate--beta-alanine ligase (panc)2 from thermotoga maritima
87 | c3mxtA_ |
| not modelled | 55.8 | 18 | PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine ligase from campylobacter2 jejuni
88 | d1auga_ |
| not modelled | 54.5 | 33 | Fold:Phosphorylase/hydrolase-like Superfamily:Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) Family:Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)
89 | c2jfqA_ |
| not modelled | 47.6 | 19 | PDB header:isomerase Chain: A: PDB Molecule:glutamate racemase; PDBTitle: crystal structure of staphylococcus aureus glutamate2 racemase in complex with d-glutamate
90 | c3uk2B_ |
| not modelled | 44.8 | 13 | PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: the structure of pantothenate synthetase from burkholderia2 thailandensis
91 | c2jfoB_ |
| not modelled | 40.9 | 19 | PDB header:isomerase Chain: B: PDB Molecule:glutamate racemase; PDBTitle: crystal structure of enterococcus faecalis glutamate2 racemase in complex with d- and l-glutamate
92 | d1v8fa_ |
| not modelled | 40.4 | 17 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
93 | d1f0ka_ |
| not modelled | 39.0 | 14 | Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Peptidoglycan biosynthesis glycosyltransferase MurG
94 | c2gzmB_ |
| not modelled | 36.7 | 19 | PDB header:isomerase Chain: B: PDB Molecule:glutamate racemase; PDBTitle: crystal structure of the glutamate racemase from bacillus2 anthracis
95 | d1ihoa_ |
| not modelled | 31.0 | 16 | Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
96 | c3n8hA_ |
| not modelled | 30.4 | 18 | PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine ligase from francisella2 tularensis
97 | c3ag5A_ |
| not modelled | 28.5 | 25 | PDB header:ligase Chain: A: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantothenate synthetase from staphylococcus2 aureus
98 | c3innB_ |
| not modelled | 27.7 | 22 | PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: crystal structure of pantoate-beta-alanine-ligase in complex2 with atp at low occupancy at 2.1 a resolution
99 | c3guzB_ |
| not modelled | 26.6 | 13 | PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: structural and substrate-binding studies of pantothenate2 synthenate (ps)provide insights into homotropic inhibition3 by pantoate in ps's
100 | c3outC_ |
| not modelled | 25.7 | 20 | PDB header:isomerase Chain: C: PDB Molecule:glutamate racemase; PDBTitle: crystal structure of glutamate racemase from francisella tularensis2 subsp. tularensis schu s4 in complex with d-glutamate.
101 | d1htjf_ |
| not modelled | 24.2 | 13 | Fold:Regulator of G-protein signaling, RGS Superfamily:Regulator of G-protein signaling, RGS Family:Regulator of G-protein signaling, RGS
102 | c1htjF_ |
| not modelled | 24.2 | 13 | PDB header:signaling protein Chain: F: PDB Molecule:kiaa0380; PDBTitle: structure of the rgs-like domain from pdz-rhogef
103 | d1kgda_ |
| not modelled | 23.3 | 38 | Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases
104 | c2qjcA_ |
| not modelled | 23.2 | 10 | PDB header:hydrolase Chain: A: PDB Molecule:diadenosine tetraphosphatase, putative; PDBTitle: crystal structure of a putative diadenosine tetraphosphatase
105 | d1e6ca_ |
| not modelled | 22.9 | 41 | Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Shikimate kinase (AroK)

Binding site prediction |

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0