Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	I	A	C	L	S	A	L	A	A	V	L	A	F	T	A	G	T	S	V	A	A	T	S	T	V	T	G	G	Y	A	Q	S	D	A	Q	G	Q	M	N	K	M	G	G	F	N	L	K	Y	R	Y	E	E	D	N	S	P	L
Secondary structure
SS confidence
Disorder		?	?	?	?												?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	I	G	S	F	T	Y	T	E	K	S	R	T	A	S	S	G	D	Y	N	K	N	Q	Y	Y	G	I	T	A	G	P	A	Y	R	I	N	D	W	A	S	I	Y	G	V	V	G	V	G	Y	G	K	F	Q	T	T	E	Y	P	T
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?																																					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.
Sequence		Y	K	H	D	T	S	D	Y	G	F	S	Y	G	A	G	L	Q	F	N	P	M	E	N	V	A	L	D	F	S	Y	E	Q	S	R	I	R	S	V	D	V	G	T	W	I	A	G	V	G	Y	R	F
Secondary structure
SS confidence
Disorder		?	?	?	?		?																												?	?		?													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1qj8 chain A Region: 24 - 171 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 99% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 3qra chain A Region: 22 - 171 Aligned: 148 Modelled: 150 Confidence: 100.0% Identity: 45% PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis Phyre2 PDB 1qjp chain A Region: 20 - 171 Aligned: 136 Modelled: 152 Confidence: 99.9% Identity: 19% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 3nb3 chain C Region: 20 - 171 Aligned: 136 Modelled: 152 Confidence: 99.9% Identity: 20% PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components Phyre2 PDB 1g90 chain A Region: 20 - 171 Aligned: 151 Modelled: 152 Confidence: 99.9% Identity: 20% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1p4t chain A Region: 20 - 171 Aligned: 148 Modelled: 152 Confidence: 99.9% Identity: 17% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 2k0l chain A Region: 8 - 171 Aligned: 163 Modelled: 164 Confidence: 99.9% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. Phyre2 PDB 2f1t chain B Region: 22 - 171 Aligned: 149 Modelled: 150 Confidence: 99.9% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw Phyre2 PDB 2x27 chain X Region: 18 - 171 Aligned: 153 Modelled: 154 Confidence: 99.9% Identity: 19% PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa Phyre2 PDB 2jmm chain A Region: 22 - 171 Aligned: 143 Modelled: 150 Confidence: 99.9% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein Phyre2 PDB 2lhf chain A Region: 36 - 171 Aligned: 131 Modelled: 136 Confidence: 99.7% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles Phyre2 PDB 1uyn chain X Region: 46 - 171 Aligned: 122 Modelled: 126 Confidence: 99.1% Identity: 18% Fold: Transmembrane beta-barrels Superfamily: Autotransporter Family: Autotransporter Phyre2 PDB 3dwo chain X Region: 34 - 171 Aligned: 137 Modelled: 138 Confidence: 98.9% Identity: 20% PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue Phyre2 PDB 3aeh chain B Region: 46 - 171 Aligned: 117 Modelled: 126 Confidence: 98.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp Phyre2 PDB 1pho chain A Region: 39 - 171 Aligned: 123 Modelled: 129 Confidence: 98.9% Identity: 17% Fold: Transmembrane beta-barrels Superfamily: Porins Family: Porin Phyre2 PDB 1t16 chain A Region: 35 - 171 Aligned: 134 Modelled: 137 Confidence: 98.9% Identity: 15% Fold: Transmembrane beta-barrels Superfamily: Porins Family: Outer membrane protein transport protein Phyre2 PDB 2zfg chain A domain 1 Region: 36 - 171 Aligned: 130 Modelled: 136 Confidence: 98.8% Identity: 15% Fold: Transmembrane beta-barrels Superfamily: Porins Family: Porin Phyre2 PDB 1osm chain A Region: 36 - 171 Aligned: 127 Modelled: 136 Confidence: 98.7% Identity: 13% Fold: Transmembrane beta-barrels Superfamily: Porins Family: Porin Phyre2 PDB 3kvn chain A Region: 31 - 171 Aligned: 141 Modelled: 141 Confidence: 98.6% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa Phyre2 PDB 3slj chain A Region: 46 - 171 Aligned: 126 Modelled: 126 Confidence: 98.5% Identity: 16% PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant Phyre2 1 d1qj8a_ 2 c3qraA_ 3 d1qjpa_ 4 c3nb3C_ 5 d1g90a_ 6 d1p4ta_ 7 c2k0lA_ 8 c2f1tB_ 9 c2x27X_ 10 c2jmmA_ 11 c2lhfA_ 12 d1uynx_ 13 c3dwoX_ 14 c3aehB_ 15 d1phoa_ 16 d1t16a_ 17 d2zfga1 18 d1osma_ 19 c3kvnA_ 20 c3sljA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1qj8a_ 100.0 99 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 2 c3qraA_ 100.0 45 PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis 3 d1qjpa_ 99.9 19 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 4 c3nb3C_ 99.9 20 PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components 5 d1g90a_ 99.9 20 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 6 d1p4ta_ 99.9 17 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 7 c2k0lA_ 99.9 20 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. 8 c2f1tB_ 99.9 17 PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw 9 c2x27X_ 99.9 19 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa 10 c2jmmA_ 99.9 17 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein 11 c2lhfA_ 99.7 16 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles 12 d1uynx_ 99.1 18 Fold:Transmembrane beta-barrels Superfamily:Autotransporter Family:Autotransporter 13 c3dwoX_ 98.9 20 PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue 14 c3aehB_ 98.9 20 PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp 15 d1phoa_ 98.9 17 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 16 d1t16a_ 98.9 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Outer membrane protein transport protein 17 d2zfga1 98.8 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 18 d1osma_ 98.7 13 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 19 c3kvnA_ 98.6 15 PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa 20 c3sljA_ 98.5 16 PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant 21 d2fgqx1 not modelled 98.5 12 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 22 c3a2rX_ not modelled 98.5 13 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein ii; PDBTitle: crystal structure of outer membrane protein porb from neisseria2 meningitidis 23 c3nsgA_ not modelled 98.4 18 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein f; PDBTitle: crystal structure of ompf, an outer membrane protein from salmonella2 typhi 24 c3qq2C_ not modelled 98.4 19 PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka 25 c2qomB_ not modelled 98.2 18 PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. 26 c3brzA_ not modelled 98.1 7 PDB header:transport protein Chain: A: PDB Molecule:todx; PDBTitle: crystal structure of the pseudomonas putida toluene2 transporter todx 27 c3bryB_ not modelled 98.1 12 PDB header:transport protein Chain: B: PDB Molecule:tbux; PDBTitle: crystal structure of the ralstonia pickettii toluene2 transporter tbux 28 c2x4mD_ not modelled 98.0 19 PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla 29 c2iwvD_ not modelled 97.2 11 PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation 30 d3prna_ not modelled 97.2 16 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 31 d1i78a_ not modelled 96.4 19 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane protease OMPT 32 c2wjqA_ not modelled 96.4 12 PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. 33 d2pora_ not modelled 95.8 16 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 34 c2ervA_ not modelled 95.5 13 PDB header:membrane protein Chain: A: PDB Molecule:hypothetical protein paer03002360; PDBTitle: crystal structure of the outer membrane enzyme pagl 35 d2gufa1 not modelled 94.6 7 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 36 c3dzmB_ not modelled 94.5 19 PDB header:unknown function Chain: B: PDB Molecule:hypothetical conserved protein; PDBTitle: crystal structure of a major outer membrane protein from thermus2 thermophilus hb27 37 c2o4vA_ not modelled 93.8 13 PDB header:membrane protein Chain: A: PDB Molecule:porin p; PDBTitle: an arginine ladder in oprp mediates phosphate specific transfer across2 the outer membrane 38 c2iahA_ not modelled 93.7 8 PDB header:membrane protein Chain: A: PDB Molecule:ferripyoverdine receptor; PDBTitle: crystal structure of the ferripyoverdine receptor of the outer2 membrane of pseudomonas aeruginosa bound to ferripyoverdine. 39 c2hdiA_ not modelled 93.5 13 PDB header:protein transport,antimicrobial protein Chain: A: PDB Molecule:colicin i receptor; PDBTitle: crystal structure of the colicin i receptor cir from e.coli in complex2 with receptor binding domain of colicin ia. 40 c2grxB_ not modelled 89.6 12 PDB header:metal transport Chain: B: PDB Molecule:ferrichrome-iron receptor; PDBTitle: crystal structure of tonb in complex with fhua, e. coli2 outer membrane receptor for ferrichrome 41 d1af6a_ not modelled 84.3 12 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like 42 d1a0tp_ not modelled 83.7 13 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like 43 d1by5a_ not modelled 82.2 12 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 44 c3efmA_ not modelled 79.0 8 PDB header:membrane protein Chain: A: PDB Molecule:ferric alcaligin siderophore receptor; PDBTitle: structure of the alcaligin outer membrane recepteur faua from2 bordetella pertussis 45 d2vdfa1 not modelled 78.7 14 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane adhesin/invasin OpcA 46 d2mpra_ not modelled 74.0 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like 47 d1fepa_ not modelled 72.6 12 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 48 d2gr7a1 not modelled 51.0 23 Fold:Pili subunits Superfamily:Pili subunits Family:YadA C-terminal domain-like 49 c2gr7C_ not modelled 51.0 23 PDB header:membrane protein Chain: C: PDB Molecule:adhesin; PDBTitle: hia 992-1098 50 d2jnaa1 not modelled 49.5 29 Fold:Dodecin subunit-like Superfamily:YdgH-like Family:YdgH-like 51 c1xkhC_ not modelled 45.9 11 PDB header:membrane protein Chain: C: PDB Molecule:ferripyoverdine receptor; PDBTitle: pyoverdine outer membrane receptor fpva from pseudomonas aeruginosa2 pao1 bound to pyoverdine 52 d2gr8a1 not modelled 36.6 24 Fold:Pili subunits Superfamily:Pili subunits Family:YadA C-terminal domain-like 53 c3emoA_ not modelled 33.6 24 PDB header:membrane protein/cell adhesion Chain: A: PDB Molecule:hia (adhesin); PDBTitle: crystal structure of transmembrane hia 973-1098 54 c3qlbA_ not modelled 33.3 11 PDB header:metal transport Chain: A: PDB Molecule:enantio-pyochelin receptor; PDBTitle: enantiopyochelin outer membrane tonb-dependent transporter from2 pseudomonas fluorescens bound to the ferri-enantiopyochelin 55 c1xkwA_ not modelled 31.3 9 PDB header:membrane protein Chain: A: PDB Molecule:fe(iii)-pyochelin receptor; PDBTitle: pyochelin outer membrane receptor fpta from pseudomonas2 aeruginosa 56 c2y0hA_ not modelled 31.0 8 PDB header:transport protein Chain: A: PDB Molecule:probable porin; PDBTitle: crystal structure of pseudomonas aeruginosa opdl 57 c2k3aA_ not modelled 13.6 19 PDB header:hydrolase Chain: A: PDB Molecule:chap domain protein; PDBTitle: nmr solution structure of staphylococcus saprophyticus chap2 (cysteine, histidine-dependent amidohydrolases/peptidases)3 domain protein. northeast structural genomics consortium4 target syr11 58 c3fhhA_ not modelled 13.1 13 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane heme receptor shua; PDBTitle: crystal structure of the heme/hemoglobin outer membrane2 transporter shua from shigella dysenteriae 59 c2qdzA_ not modelled 12.8 13 PDB header:protein transport Chain: A: PDB Molecule:tpsb transporter fhac; PDBTitle: structure of the membrane protein fhac: a member of the2 omp85/tpsb transporter family 60 c2kerA_ not modelled 11.8 15 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:alpha-amylase inhibitor z-2685; PDBTitle: alpha-amylase inhibitor parvulustat (z-2685) from2 streptomyces parvulus 61 d1ok0a_ not modelled 10.5 26 Fold:alpha-Amylase inhibitor tendamistat Superfamily:alpha-Amylase inhibitor tendamistat Family:alpha-Amylase inhibitor tendamistat 62 c3egbA_ not modelled 9.6 15 PDB header:protein binding Chain: A: PDB Molecule:protein pellino homolog 2; PDBTitle: structure of pellino2 fha domain at 3.3 angstroms2 resolution. 63 c2y0kA_ not modelled 7.8 9 PDB header:transport protein Chain: A: PDB Molecule:pyroglutatmate porin opdo; PDBTitle: crystal structure of pseudomonas aeruginosa opdo 64 c2odjA_ not modelled 7.1 11 PDB header:membrane protein Chain: A: PDB Molecule:porin d; PDBTitle: crystal structure of the outer membrane protein oprd from pseudomonas2 aeruginosa 65 d1kmoa_ not modelled 6.7 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 66 c2k4tA_ not modelled 6.6 18 PDB header:membrane protein,apoptosis Chain: A: PDB Molecule:voltage-dependent anion-selective channel PDBTitle: solution structure of human vdac-1 in ldao micelles

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0