BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (316 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 436 e-121 UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 422 e-116 UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 372 e-101 UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 367 e-100 UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 365 e-100 UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 357 2e-97 UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 325 9e-88 UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organis... 323 5e-87 UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 321 3e-86 UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium... 320 4e-86 UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5... 319 8e-86 UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2... 316 9e-85 UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 314 2e-84 UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C... 311 2e-83 UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 308 1e-82 UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 307 2e-82 UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 301 2e-80 UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 293 5e-78 UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 286 6e-76 UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 3e-74 UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 278 2e-73 UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 276 6e-73 UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 270 7e-71 UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 267 3e-70 UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 265 1e-69 UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 265 2e-69 UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepI... 249 9e-65 UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 244 3e-63 UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_P... 238 3e-61 UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 237 4e-61 UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 226 8e-58 UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 219 1e-55 UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 207 3e-52 UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 183 6e-45 UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 182 1e-44 UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7... 178 2e-43 UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4... 177 3e-43 UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 177 6e-43 UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 176 1e-42 UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipe... 171 3e-41 UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 170 5e-41 UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 169 8e-41 UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 167 5e-40 UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 165 2e-39 UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 165 2e-39 UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1... 164 3e-39 UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 163 8e-39 UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostri... 162 1e-38 UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphospha... 162 1e-38 UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3... 161 3e-38 UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collins... 160 6e-38 UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 159 1e-37 UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax... 159 1e-37 UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 158 3e-37 UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 157 3e-37 UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 156 1e-36 UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 154 3e-36 UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 153 8e-36 UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 153 1e-35 UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 153 1e-35 UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 152 1e-35 UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 152 1e-35 UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=5... 151 2e-35 UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 151 4e-35 UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 150 6e-35 UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 150 8e-35 UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 149 1e-34 UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1... 149 2e-34 UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 148 2e-34 UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 148 3e-34 UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 147 4e-34 UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 147 5e-34 UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 147 5e-34 UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 145 1e-33 UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 145 2e-33 UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 145 2e-33 UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 145 2e-33 UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 145 2e-33 UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 144 5e-33 UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 143 7e-33 UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate ... 143 1e-32 UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphat... 142 2e-32 UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 142 2e-32 UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate ... 141 2e-32 UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 141 3e-32 UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1... 141 3e-32 UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 140 5e-32 UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 140 5e-32 UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 140 7e-32 UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8... 139 9e-32 UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 139 1e-31 UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 139 2e-31 UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 138 2e-31 UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/rib... 138 3e-31 UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 137 4e-31 UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2... 137 4e-31 UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 137 5e-31 UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candida... 134 3e-30 UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 134 5e-30 UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2... 133 8e-30 UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteri... 132 1e-29 UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerof... 132 2e-29 UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 131 3e-29 UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 130 4e-29 UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 130 5e-29 UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 130 7e-29 UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 129 1e-28 UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 129 2e-28 UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 128 3e-28 UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2... 127 6e-28 UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2... 126 8e-28 UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 126 1e-27 UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammapr... 125 2e-27 UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 125 2e-27 UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 122 2e-26 UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 120 6e-26 UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 119 1e-25 UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate ... 117 4e-25 UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 116 1e-24 UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudona... 114 3e-24 UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 113 7e-24 UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 112 2e-23 UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 112 2e-23 UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 112 2e-23 UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyt... 111 3e-23 UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 110 5e-23 UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 110 7e-23 UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 110 9e-23 UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 110 9e-23 UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 T... 110 9e-23 UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellu... 106 1e-21 UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 105 2e-21 UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 104 4e-21 UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 100 1e-19 UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 99 2e-19 UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 97 5e-19 UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCM... 97 6e-19 UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 96 1e-18 UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 96 2e-18 UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 96 2e-18 UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 96 2e-18 UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 95 3e-18 UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1... 92 2e-17 UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reducta... 90 8e-17 UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 90 1e-16 UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q... 89 3e-16 UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP 88 4e-16 UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 88 5e-16 UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 83 1e-14 UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 81 4e-14 UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 74 8e-12 UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 67 1e-09 UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 50 1e-04 UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia... 46 0.001 >UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=23 Tax=Proteobacteria RepID=ISPH_MARAV Length = 316 Score = 436 bits (1120), Expect = e-121, Method: Compositional matrix adjust. Identities = 213/316 (67%), Positives = 255/316 (80%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI IV AL ++GAPIYVRHEVVHN++VVD+LR RGAIF++++ Sbjct: 1 MQIRLANPRGFCAGVDRAIEIVNRALDVFGAPIYVRHEVVHNKFVVDNLRNRGAIFVDEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPD ++IFSAHGVSQAV+NEA R L VFDATCPLVTKVHMEV R SR G E ILIG Sbjct: 61 GEVPDDKLVIFSAHGVSQAVQNEAARRGLKVFDATCPLVTKVHMEVMRYSRDGRECILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMGQY + GG +YLVE DV KL VK+ +LSF+TQTTLS+DDT+ VID Sbjct: 121 HHGHPEVEGTMGQYDHSNGGDIYLVEDEADVQKLEVKDPSRLSFVTQTTLSMDDTARVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALR +FP+I GPRKDDICYAT NRQ+AV+ LA +++LVVGS NSSNSNRL ELA+RMG Sbjct: 181 ALRAKFPQIEGPRKDDICYATQNRQDAVKQLAGDCDIMLVVGSPNSSNSNRLRELAERMG 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 A+LID+A I W+ K +GVTAGASAP++LV +V+ RL+ LGG E + + GREE+ Sbjct: 241 TPAYLIDEAAQIDPAWLYGKKAIGVTAGASAPEVLVADVIKRLKALGGEEPVEVSGREES 300 Query: 300 IVFEVPKELRVDIREV 315 IVF +PKELR+D E+ Sbjct: 301 IVFSMPKELRIDAVEL 316 >UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=187 Tax=Bacteria RepID=ISPH_PSYWF Length = 318 Score = 422 bits (1084), Expect = e-116, Method: Compositional matrix adjust. Identities = 206/316 (65%), Positives = 260/316 (82%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI+IV ALA + PIYVRHEVVHN++VV L RGA+F+E++ Sbjct: 1 MQIYLANPRGFCAGVDRAIAIVNEALARFEPPIYVRHEVVHNKFVVSDLANRGAVFVEEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPDG+I+IFSAHGVS+AV +EA+ RDLTVFDATCPLVTKVH+EVA+ +R +++LIG Sbjct: 61 HEVPDGSIVIFSAHGVSKAVEDEAERRDLTVFDATCPLVTKVHIEVAKFAREKMDAVLIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMG++S GG ++LVE+ DV KL V + ++L+F+TQTTLS+DDT+ VID Sbjct: 121 HQGHPEVEGTMGRFSAQYGGEIHLVENEADVEKLEVSDPDRLAFVTQTTLSMDDTAVVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALRK+FP I GPRKDDICYAT NRQ+AV+ LA++ EVVLVVGS NSSNSNRL ELA+RM Sbjct: 181 ALRKKFPNIQGPRKDDICYATQNRQDAVKDLAQRCEVVLVVGSPNSSNSNRLRELAERMN 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 +A+LID+A ++++EW V VGVTAGASAP+IL+Q V+ +LQQ GG L+G EEN Sbjct: 241 CKAYLIDNAGEMKKEWFAGVGAVGVTAGASAPEILIQEVLNQLQQWGGDLPDELKGIEEN 300 Query: 300 IVFEVPKELRVDIREV 315 + F +PKELR+ ++EV Sbjct: 301 VTFSLPKELRIPVKEV 316 >UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=437 Tax=cellular organisms RepID=ISPH_POLSJ Length = 333 Score = 372 bits (954), Expect = e-101, Method: Compositional matrix adjust. Identities = 175/310 (56%), Positives = 239/310 (77%), Gaps = 3/310 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +ILLA PRGFCAGVDRAI IVE AL +GAPIYVRHE+VHN YVV+ L+ +GAIFIE++S Sbjct: 10 EILLAEPRGFCAGVDRAIEIVERALTKFGAPIYVRHEIVHNTYVVNELKAKGAIFIEELS 69 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP GA L+FSAHGVS+A+++EA++R +FDATCPLVTKVH+EVA+ + G E I+IGH Sbjct: 70 DVPPGATLVFSAHGVSKAIQDEARARGFQIFDATCPLVTKVHVEVAKLHKEGYEFIMIGH 129 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GHPEVEGTMGQ + G++LVE DV ++T E+L+ +TQTTLSVDD +++ A+ Sbjct: 130 KGHPEVEGTMGQL---DSGIHLVEDVADVARITPSQTERLAVVTQTTLSVDDAAEISAAV 186 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + RFP++ P++ DICYAT NRQ+AV+ L+ Q ++++VVGS SSNSNRL ELA ++G Sbjct: 187 KARFPQVREPKQQDICYATQNRQDAVKVLSPQVDILIVVGSPTSSNSNRLRELAAKLGTE 246 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 A+++DDA +++E W + VG+TAGASAP+ILV+ V+ R++ LG ++G EE I Sbjct: 247 AYMVDDASELRESWFEGKSRVGLTAGASAPEILVKQVIDRIRALGAVSVRKMDGIEETIK 306 Query: 302 FEVPKELRVD 311 F +PK L+VD Sbjct: 307 FPLPKGLKVD 316 >UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Proteobacteria RepID=ISPH_WIGBR Length = 315 Score = 367 bits (943), Expect = e-100, Method: Compositional matrix adjust. Identities = 164/315 (52%), Positives = 238/315 (75%), Gaps = 2/315 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I LANPRGFCAGVDRAI+IV+NA+ IYG PIYV +EVVHN+YVV+SL++ G+IF+++I Sbjct: 1 MNIFLANPRGFCAGVDRAINIVKNAIEIYGPPIYVYNEVVHNKYVVNSLKKIGSIFVKKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP+ +ILIFSAHGVS+++ EA R L +FDATCPLV+KVH E+ RAS+ E I+IG Sbjct: 61 CDVPEKSILIFSAHGVSKSILKEANKRKLIIFDATCPLVSKVHHEIKRASKLRSEVIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+ GT+GQY+NP +++++S +++ KL +K+ L + TQTTLSVDDT+ +I A Sbjct: 121 HKNHPEIIGTIGQYNNPNKKVFVIQSIEEICKLKIKDPNNLFYFTQTTLSVDDTNKIIFA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++K++P I+ PRK DICYAT NRQ++++ + + +++ ++GSKNSSNSNRL E+A + GK Sbjct: 181 IKKKYPYIIEPRKKDICYATENRQKSIKKIIKLVDIIFIIGSKNSSNSNRLFEIANKSGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA--IPLEGREE 298 +++LID K+I++ W+ V +G+TAGASAP+ILVQ VV L+ ++G E Sbjct: 241 KSYLIDTYKEIKKSWLNGVNNIGITAGASAPEILVQQVVNYLKIFYKNSVNIYQVDGDIE 300 Query: 299 NIVFEVPKELRVDIR 313 F +PK+L + I+ Sbjct: 301 KTKFMIPKKLILKIK 315 >UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_BUCA5 Length = 319 Score = 365 bits (938), Expect = e-100, Method: Compositional matrix adjust. Identities = 171/308 (55%), Positives = 237/308 (76%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+L NPRGFCAGV RAI IVENAL +Y IY+RHE+VHN+YV+++LR++G +F+E+I Sbjct: 1 MNIILTNPRGFCAGVKRAILIVENALKVYKKTIYIRHELVHNQYVINTLRQKGVVFVEKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++PD +++IFSAHGVS+ V EA + L + DATCPLV KVH+EV+++S + E+ILIG Sbjct: 61 EQIPDYSVVIFSAHGVSKKVVQEAVKKKLIILDATCPLVEKVHIEVSKSSEKAIETILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GHPEVEGT+GQY+N G +YLVES +DV L+V+N +KL+F TQTTLS+ +T +I A Sbjct: 121 HRGHPEVEGTIGQYNNKNGKIYLVESIEDVHNLSVQNSKKLNFFTQTTLSITNTKKIIAA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ +FP+I GP K+DICYATTNRQ AVR L++ A+++ V+GS NSSNSNRLAEL + G Sbjct: 181 LKNKFPEISGPNKEDICYATTNRQIAVRQLSKIADIIFVIGSNNSSNSNRLAELGKETGT 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 LI DI+++W+K V +G+TAGASAP+ILV V+ L+++G + I + G E Sbjct: 241 FTKLISSFLDIKKKWLKNVNYIGITAGASAPEILVTEVIQYLRKIGAHKPIEMIGVREKK 300 Query: 301 VFEVPKEL 308 +F++PK+L Sbjct: 301 IFKIPKKL 308 >UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Proteobacteria RepID=Q3JAD0_NITOC Length = 320 Score = 357 bits (917), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 175/315 (55%), Positives = 233/315 (73%), Gaps = 4/315 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA PRGFCAGV RAI IVE+AL IYGAPIYV HE+VHN++VV+ L+ RG IF E + Sbjct: 1 MKVTLAQPRGFCAGVVRAIDIVEHALEIYGAPIYVLHEIVHNQHVVEDLQRRGVIFTEDL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + +P G++ IFSAHGVS AV AK DL V DATCPLVTKVH++ + R+G+E I+IG Sbjct: 61 ASIPAGSVTIFSAHGVSTAVVETAKKNDLQVIDATCPLVTKVHLQAKKYYRQGDELIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HAGHPEVEGT G+ +G +Y+++S +V L VK+ E ++++TQTTLS+DDT DV+DA Sbjct: 121 HAGHPEVEGTRGRV---KGTVYVLDSVAEVENLAVKDPEHIAYVTQTTLSIDDTRDVVDA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+KRFPKI GP DDICYAT NRQ AVR ++++ +++LVVG++NSSNSNRL E+ ++ G Sbjct: 178 LKKRFPKIHGPGLDDICYATQNRQNAVREMSKKVDILLVVGARNSSNSNRLREVGEQNGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A LI DAKD+ W VG+TAGAS P+ILVQ V+ L+ G E + L+G +E+I Sbjct: 238 TAHLIQDAKDLDSSWFTSQSRVGITAGASTPEILVQGVLNELRSYGVEEVMDLDGVQESI 297 Query: 301 VFEVPKEL-RVDIRE 314 F +P L R +R+ Sbjct: 298 SFRLPTMLPRAKLRQ 312 >UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=17 Tax=Rickettsiales RepID=ISPH_ANAMM Length = 342 Score = 325 bits (834), Expect = 9e-88, Method: Compositional matrix adjust. Identities = 155/308 (50%), Positives = 223/308 (72%), Gaps = 5/308 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP--IYVRHEVVHNRYVVDSLRERGAIFIE 58 ++++LA PRGFCAGV+RA+ +E+ + Y +Y HE+VHN +VV+S ++ G F+ Sbjct: 36 VEVILARPRGFCAGVERAVRTLESVASRYAGTREVYALHEIVHNLHVVNSFKKMGVKFVS 95 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + EVP+GA+L+FSAHGVSQ V+ E++ + LTV DATCPLVTKVH+E+ R + G + IL Sbjct: 96 ALHEVPEGAVLVFSAHGVSQQVKEESRRKGLTVVDATCPLVTKVHLEIQRYDKSGYQVIL 155 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +GH GH EVEG+MGQ SNP + LV++ DV + + + KL+++TQTTLS+DDT+++I Sbjct: 156 VGHKGHREVEGSMGQVSNP---VVLVQNVQDVQSIKIPSAAKLAYVTQTTLSMDDTAEII 212 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 AL+ RFP+IVGP DICYAT NRQ AV+A+++ +VVL +GSKNSSNSNRL +LA+ Sbjct: 213 SALKLRFPRIVGPDLRDICYATQNRQTAVKAMSQMVDVVLAIGSKNSSNSNRLLDLAKAQ 272 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 RA+LID ++I EW+ + +G+TAGASAP+ILVQ V+ L + ++G E Sbjct: 273 NARAYLIDSYRNIDLEWLIGARRIGITAGASAPEILVQEVIDYLGLHANLKVRTMDGVSE 332 Query: 299 NIVFEVPK 306 NI F++P+ Sbjct: 333 NITFKLPE 340 >UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organisms RepID=B3SF22_TRIAD Length = 470 Score = 323 bits (828), Expect = 5e-87, Method: Compositional matrix adjust. Identities = 147/295 (49%), Positives = 218/295 (73%), Gaps = 3/295 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +ANPRGFCAGV+RA+ IVE LA YGAP+YVRHE+VHNRYVV++L+ +GAIF+E+I Sbjct: 11 LEIFMANPRGFCAGVERAVEIVELTLAKYGAPVYVRHEIVHNRYVVENLKNKGAIFVEEI 70 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+PD A+ I+SAHGVS+ V NE++ + L + DATCPLV KVH++ + + G++ I+IG Sbjct: 71 AEIPDNAVTIYSAHGVSEKVENESRFKHLKIIDATCPLVKKVHLQAQKFEKVGDKIIIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+EGT G+ +++VE+ DV K+ +E +S++TQTTLSVDDT ++IDA Sbjct: 131 HKNHPEIEGTSGRVKRE---VFIVENIQDVEKIPFSKDESISYVTQTTLSVDDTKNIIDA 187 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ FP I GP +IC+AT NRQ+AV+ LA + + V+G+KNSSNSNRL ++A+ G Sbjct: 188 LKNAFPNIKGPELKNICFATQNRQDAVKQLASLVDTIFVIGAKNSSNSNRLRDIAENCGT 247 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG 295 +AFL++ D + + +G+TAGASAP+ILV N++A+++++ + +EG Sbjct: 248 KAFLLNGETDDISDLLHNSTKLGITAGASAPEILVSNLIAKIKKMRDVKITHVEG 302 >UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=210 Tax=cellular organisms RepID=ISPH_MYCVP Length = 337 Score = 321 bits (822), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 164/309 (53%), Positives = 218/309 (70%), Gaps = 4/309 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +GAPIYVRHE+VHNRYVVD+L + GAIF+EQ Sbjct: 28 RVLLAEPRGYCAGVDRAVETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTD 87 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GAI++FSAHGV+ V EA +R L DATCPLVTKVH E R +R + +L+GH Sbjct: 88 EVPEGAIVVFSAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGH 147 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ + + +V++PD V K+TV++ K+ +++QTTLSVD+T + + L Sbjct: 148 EGHEEVVGTAGEAPD---HVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDETMETVRRL 204 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R++FP + P DDICYAT NRQ AV+A+A + E+V+VVGSKNSSNS RL E+A G Sbjct: 205 REKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKNSSNSVRLVEVALGAGAS 264 Query: 242 -AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A L+D A DI W V VGVT+GAS P+ILV+ V+ RL + G P+ E + Sbjct: 265 AAHLVDYADDIDPAWFDGVTTVGVTSGASVPEILVRGVLDRLAEHGYDVVQPVTTANETL 324 Query: 301 VFEVPKELR 309 VF +P+E+R Sbjct: 325 VFALPREIR 333 >UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium RepID=B2HKN9_MYCMM Length = 333 Score = 320 bits (821), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 162/312 (51%), Positives = 215/312 (68%), Gaps = 7/312 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 +LLA+PR FCAGV RAI VE L P+YVR ++VHNR VV L++RGAIF++++ E Sbjct: 24 VLLASPRSFCAGVHRAIEAVERVLDRATGPVYVRKQIVHNRTVVAELQDRGAIFVDELDE 83 Query: 63 VPD----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +PD GA+++FSAHGVS AVR A R L V DATCPLVTKVH E AR + RG+ +L Sbjct: 84 IPDPPAPGAVVVFSAHGVSPAVRAAANGRGLEVVDATCPLVTKVHAEAARFAGRGDTVLL 143 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IGH GH E +GT+G N M LV++ DDV +L + + ++S++TQTTL+VD+T+DVI Sbjct: 144 IGHLGHEETDGTLGVAPN---SMLLVQNADDVTELDLPEDAQVSYLTQTTLAVDETTDVI 200 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 DALRKRFPK+ P +DICYATTNRQ AV A+ + + +LVVGS+NSSNS RL ELA+R Sbjct: 201 DALRKRFPKLAEPPTEDICYATTNRQRAVEAIVRRCDALLVVGSQNSSNSQRLVELARRR 260 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 G A+LID DI W+ +G+TAGASAP LV+ V+ L+ G + E Sbjct: 261 GTPAYLIDGPTDIDPHWLDSTATIGITAGASAPPRLVEQVIDALRLRGPINVVESPVTTE 320 Query: 299 NIVFEVPKELRV 310 ++ F +P ++RV Sbjct: 321 SVRFALPPKVRV 332 >UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5 Tax=Bacteria RepID=C9RIQ9_FIBSS Length = 310 Score = 319 bits (818), Expect = 8e-86, Method: Compositional matrix adjust. Identities = 153/309 (49%), Positives = 219/309 (70%), Gaps = 3/309 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+LA PRGFCAGVDRAI +VE A+ +G PIYVRHE+VHN++VVD+L+++G +F++++ Sbjct: 3 KIVLATPRGFCAGVDRAIHVVEKAIEKFGTPIYVRHEIVHNKFVVDTLKDKGVVFVDELD 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+++IFSAHGV++ + EAK+R+L V DA+CPLV KVH R G ILIGH Sbjct: 63 QVPEGSVVIFSAHGVAEHIYEEAKARNLQVLDASCPLVLKVHFSAKRHYNAGRHIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EVEGT+GQ PEG + L+ + +D + V +++L+++TQTTLSV +T +I+AL Sbjct: 123 AGHAEVEGTLGQL--PEGAITLIRNENDAETVDVPADKELAYITQTTLSVAETRKIIEAL 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 ++RFP I+GP D+CYAT NRQ AV L + +++LVVG+KNSSNS+RL EL G Sbjct: 181 KRRFPNIIGPEAGDLCYATGNRQAAVLELCSEVDMLLVVGAKNSSNSSRLMELGLEQGLP 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL-QQLGGGEAIPLEGREENI 300 + LI D D+ W + + VG+++GASAP++LVQ VV L ++ E L EN Sbjct: 241 SHLIADVNDLDPAWFEGIDTVGISSGASAPEVLVQGVVDWLKEKFAPVEVENLVKLVENT 300 Query: 301 VFEVPKELR 309 F +PK L+ Sbjct: 301 KFNLPKALQ 309 >UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Actinomycetales RepID=D2PN99_9ACTO Length = 358 Score = 316 bits (809), Expect = 9e-85, Method: Compositional matrix adjust. Identities = 160/313 (51%), Positives = 222/313 (70%), Gaps = 4/313 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +YG P+YVR E+VHN++VV +L+ RGAIF+++ Sbjct: 36 RVLLAAPRGYCAGVDRAVVAVEKALDLYGPPVYVRKEIVHNKHVVQTLQARGAIFVDETD 95 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G +IFSAHGV+ V EA +R L DATCPLVTKVH E R + + +LIGH Sbjct: 96 EVPEGETVIFSAHGVAPVVHQEAAARQLKTIDATCPLVTKVHHEAKRFAATDYDILLIGH 155 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ PE ++LV+ P DV + V++ EK+ +++QTTLSVD+T + + L Sbjct: 156 EGHEEVIGTSGE--APE-HIHLVDGPGDVPNVEVRDPEKVVWLSQTTLSVDETMETVRRL 212 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP + P DDICYAT NRQ AV+ LA A++++VVGS+NSSNS RL E+A G + Sbjct: 213 RERFPHLQDPPSDDICYATQNRQAAVKKLAADADLMIVVGSRNSSNSVRLVEVAVEHGAK 272 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+D A +I E W++ V VGVT+GAS P+ILV++V+ L G GE + EE++ Sbjct: 273 AGYLVDYADEIDEAWLEGVDSVGVTSGASVPEILVRDVLDWLAARGYGEVQEVTTAEESL 332 Query: 301 VFEVPKELRVDIR 313 F +P+ELR D++ Sbjct: 333 TFALPRELRTDLK 345 >UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F698_ACIC5 Length = 338 Score = 314 bits (805), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 162/307 (52%), Positives = 225/307 (73%), Gaps = 3/307 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LL PRGFCAGV RA+ IV AL +GAPIYVR E+VHNR+VV+ L E+GAIF+E I Sbjct: 21 KVLLLKPRGFCAGVVRAVDIVRIALETFGAPIYVRKEIVHNRFVVNELAEKGAIFVEDID 80 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+ +I+SAHGVS AVR ++K R+L V DATCPLVTKVH+E + +R+G +LIGH Sbjct: 81 QVPEGSRVIYSAHGVSPAVRQQSKDRNLRVIDATCPLVTKVHVEAVKFARQGYSLVLIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+EGT+G+ + +V S +V L V + +++++TQTTLS+D+ D+I+AL Sbjct: 141 RDHEEIEGTLGEAPD---VTTVVSSAAEVAALEVPDPNRVAYLTQTTLSLDEARDMIEAL 197 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +K+FP IVGP DICYAT NRQ AV+ +A QA++VLVVGS NSSNSNRL E+++ +G + Sbjct: 198 KKKFPNIVGPHSQDICYATENRQVAVKNVAHQADLVLVVGSNNSSNSNRLVEVSRNLGTK 257 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 +LID++K I+ EW++ V V VTAGASAP++LV++VV L G G +E EN+ Sbjct: 258 GYLIDNSKAIRPEWLEGVATVAVTAGASAPEVLVEDVVKYLGSKGFGSVEEVEVMPENVR 317 Query: 302 FEVPKEL 308 F +P E+ Sbjct: 318 FGLPPEI 324 >UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C516_9PLAN Length = 310 Score = 311 bits (798), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 151/309 (48%), Positives = 217/309 (70%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LANPRGFCAGV+ AI +E + I+G+ +YV HE+VHN+YVV+ +G F+E + Sbjct: 1 MKVILANPRGFCAGVNMAIECLEEVIRIFGSNVYVYHEIVHNKYVVNRFTNQGVTFVEAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEVP+ +IL+FSAHGVS +RN+A+ R++ DATCPLVTKVH E + + G ILIG Sbjct: 61 SEVPENSILVFSAHGVSPVIRNQARERNIRTIDATCPLVTKVHTEAIKYADAGYHIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ PE + L+E+P++V L +L+F+TQTTLSV++ VI + Sbjct: 121 HEGHDEVIGTMGE--APE-SITLIETPEEVAALEFPEGARLAFLTQTTLSVEEAGRVIRS 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L++++P I P K+DICYATTNRQEAV L + ++VLV+GS+NSSNS RL E+ + GK Sbjct: 178 LKEKYPAIESPPKEDICYATTNRQEAVSELVSRVDLVLVLGSQNSSNSKRLMEIGKTAGK 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 AFLID +++ EW + + + +TAGASAP+++VQ ++ L+ E R+E++ Sbjct: 238 PAFLIDGVEEVLPEWFDQAETILITAGASAPEVVVQELIQFLEDNYQAEVENAIVRKESV 297 Query: 301 VFEVPKELR 309 F +PKELR Sbjct: 298 RFPLPKELR 306 >UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Bacteria RepID=ISPH_ACIC1 Length = 340 Score = 308 bits (790), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 151/313 (48%), Positives = 220/313 (70%), Gaps = 4/313 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGV+RA+ VE AL +YG P+YVR ++VHN++VV L +GAIF+E+ Sbjct: 11 RVLLAQPRGYCAGVERAVDTVEKALELYGPPVYVRKQIVHNKHVVAELEAKGAIFVEEAD 70 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G+I++ SAHGV+ +V +A+ R L DATCPLVTKVH E R + +G E +LIGH Sbjct: 71 EVPEGSIVVLSAHGVAPSVYEQARQRRLKTIDATCPLVTKVHQEARRFAEQGLEILLIGH 130 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 A H EV GT G+ + + LV+ P++ + VK+ ++++++QTTLSVD+T ++ L Sbjct: 131 ANHEEVVGTTGEAPS---SITLVDGPEEAEHVQVKDPSRVAWLSQTTLSVDETLQTVEVL 187 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP+++ P DDICYAT NRQ AV+ +A A++V+VVGS+NSSNS RL E+A G + Sbjct: 188 RRRFPQLIDPPSDDICYATQNRQAAVKRIAAIADLVIVVGSRNSSNSARLVEVALDSGAK 247 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+DDA +I E W+ V VGVT+GAS P+ LV V+A L + G ++ E + Sbjct: 248 ASYLVDDASEIDERWLDGVWTVGVTSGASVPESLVTGVLAWLAERGFDTVEEIDAERETL 307 Query: 301 VFEVPKELRVDIR 313 VF +P ELR +++ Sbjct: 308 VFALPPELRRELK 320 >UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Bacteria RepID=ISPH_RHOBA Length = 319 Score = 307 bits (787), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 158/309 (51%), Positives = 214/309 (69%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA PRGFCAGV+ AI ++ L +G P+YV HE+VHN++VV + RE+GA+F++ I Sbjct: 4 MKIILAAPRGFCAGVNMAIDSLDLTLQKFGPPVYVYHEIVHNQFVVKTFREKGAVFVDTI 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVP+G +L+FSAHGVS +R A++R L DATCPLVTKVH+E + ++ G ILIG Sbjct: 64 DEVPEGGVLLFSAHGVSPEIRKAAQARKLHALDATCPLVTKVHLEAIKYAKAGYTIILIG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ PE + LVE DV +L + +L+++TQTTLSVDD VI Sbjct: 124 HEGHDEVLGTMGE--APE-AIVLVEDEADVDRLEFEPGTQLAYLTQTTLSVDDAGRVIRR 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR+RFP+I P KDDICYAT NRQEAV+ L E A+V++V+GS+NSSNS RL ELA GK Sbjct: 181 LRERFPEIHSPPKDDICYATQNRQEAVKLLREDADVIVVLGSQNSSNSQRLKELAAEQGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 RA L+D +D+ + + V +TAGASAP+ +VQ+ + L++ REE++ Sbjct: 241 RAMLVDGPQDLAVDQFSDDDRVLITAGASAPESVVQSTIDWLKENFDASVDTQVVREEDV 300 Query: 301 VFEVPKELR 309 F +PK LR Sbjct: 301 QFPLPKPLR 309 >UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=83 Tax=Alphaproteobacteria RepID=ISPH_BRUA1 Length = 346 Score = 301 bits (771), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 147/283 (51%), Positives = 203/283 (71%), Gaps = 6/283 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I L PRGFCAGVDRAI IV AL YGAP+YVRHE+VHNRYVV+ L+ RGAIF+E++ Sbjct: 8 LEIRLCGPRGFCAGVDRAIQIVVLALKKYGAPVYVRHEIVHNRYVVEGLQARGAIFVEEL 67 Query: 61 SEVPDG---AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+P ++FSAHGV ++V +A++++L DATCPLV+KVH + R R G I Sbjct: 68 DEIPAAHRNQPVVFSAHGVPKSVPADAEAKNLFYLDATCPLVSKVHKQAMRHQRLGRHVI 127 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 LIGH+GHPEV GTMGQ P+G + L+E+ +D +E+ L F+TQTTLSVDDT+ + Sbjct: 128 LIGHSGHPEVIGTMGQL--PDGAVTLIETVEDAHTCHFDDEDNLGFVTQTTLSVDDTAGI 185 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I L+ RFP + P + ICYATTNRQ+AVRA A ++ L+VG+ NSSNS RL E+A++ Sbjct: 186 IKELQARFPNLAAPAAESICYATTNRQDAVRAAAPGCDLFLIVGAPNSSNSKRLVEVAEK 245 Query: 238 MGKR-AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVV 279 G R + L+ A+DI+ E + ++ VG++AGASAP+I+V ++ Sbjct: 246 AGARMSMLVQRAEDIEWEQIGDISVVGLSAGASAPEIIVDEII 288 >UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Chlamydiales RepID=ISPH_PARUW Length = 313 Score = 293 bits (751), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 149/308 (48%), Positives = 208/308 (67%), Gaps = 3/308 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++LL+ PRGFCAGV+RAI VE AL ++G+PIYV+HE+VHNR+VV L+ +GAIFIE + Sbjct: 1 MKLLLSKPRGFCAGVERAIETVEKALLLWGSPIYVKHEIVHNRHVVQGLKTKGAIFIEDV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP GA LI+SAHGVS AVR +AK R L DATC LVT+VH V R + +G + ILIG Sbjct: 61 EDVPVGARLIYSAHGVSPAVREQAKKRQLIEIDATCGLVTRVHSAVKRYALQGYQIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H H E+ GT G+ + +VES +DV L +++KL ++TQTTLS+DD ++ A Sbjct: 121 HHNHVEIIGTAGEAPDV---TTIVESVEDVKNLNFSSQDKLFYITQTTLSLDDVKEITQA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L ++P + ICYATTNRQ A+R + + ++VLVVG SSNSNRL E A G Sbjct: 178 LIVKYPHVETLPSSSICYATTNRQMALREITDLTDLVLVVGDPQSSNSNRLREAASTRGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 ++LI+D K+I EW+ + +G+TAGAS P+ +VQ + L +LG E + E++ Sbjct: 238 ESYLINDEKEIHPEWLLGKQVIGLTAGASTPEEIVQKCIQCLIELGVNEVEDIVYTHEDV 297 Query: 301 VFEVPKEL 308 VF++PK + Sbjct: 298 VFQLPKPI 305 >UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Alphaproteobacteria RepID=C9D092_9RHOB Length = 556 Score = 286 bits (732), Expect = 6e-76, Method: Compositional matrix adjust. Identities = 134/230 (58%), Positives = 180/230 (78%), Gaps = 2/230 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + + LA PRGFCAGVDRAI IVE AL +GAP+YVRHE+VHN++VVD LR++GA+F+E++ Sbjct: 7 LMLYLAAPRGFCAGVDRAIKIVEMALEKWGAPVYVRHEIVHNKFVVDGLRDKGAVFVEEL 66 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E PD +IFSAHGV ++V A++R++ DATCPLV+KVH+E R + G + I+IG Sbjct: 67 EECPDDRPVIFSAHGVPKSVPAAAQAREMVFVDATCPLVSKVHIEAQRHAEAGLQMIMIG 126 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GHPE GTMGQ PEG + LVE+ +DV + V++ E+L+F+TQTTLSVDDT D++ A Sbjct: 127 HKGHPETIGTMGQL--PEGEVLLVETVEDVAHVDVRDPERLAFVTQTTLSVDDTKDIVAA 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 L+ RFP I+GP K+DICYATTNRQEAV+ +A +++ +LVVG+ NSSNS R Sbjct: 185 LQTRFPAIIGPHKEDICYATTNRQEAVKEVAPKSDALLVVGAPNSSNSRR 234 >UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=A1A2C9_BIFAA Length = 343 Score = 280 bits (717), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 155/333 (46%), Positives = 213/333 (63%), Gaps = 28/333 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAP-------IYVRHEVVHNRYVVDSLRERGA 54 +I+LA+PRGFCAGVDRAI V L P +YVR ++VHN++VV+ L +GA Sbjct: 13 RIVLADPRGFCAGVDRAILTVRTILKSADTPRADGLPPVYVRRQIVHNKHVVEDLAAQGA 72 Query: 55 IFIEQISEVPDGAI-----LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA 109 +F+++++E+PD A ++FSAHGVS AV+ EA +R + V DATCPLV+KVH EV R Sbjct: 73 VFVQELAEIPDAAAEAGIPIVFSAHGVSPAVKAEATARGMHVVDATCPLVSKVHREVLRF 132 Query: 110 SRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTL 169 + G E I IGH GH E G + + +PE ++L+E DV L + + KL +TQTTL Sbjct: 133 VKEGYEIIYIGHKGHDEAVGVVEE--SPEH-VHLIEHASDVDSLDFQPDTKLVLLTQTTL 189 Query: 170 SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSN 229 SVD+T+ I AL+ RFP + P DICYAT+NRQ AV+ +AEQA+ V++VGS NSSNS Sbjct: 190 SVDETAGTITALKARFPWLEMPPNSDICYATSNRQAAVKLVAEQADCVVIVGSANSSNSV 249 Query: 230 RLAELAQR-------------MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQ 276 RL E+AQ RA +DDA ++ W + V+ VG+++GAS PD LV Sbjct: 250 RLMEVAQEGLSARYASKTAVGAAGRAHRVDDASELDPAWFEGVESVGISSGASVPDELVS 309 Query: 277 NVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 VVA LQ+LG + +E +EN+ F +P ELR Sbjct: 310 GVVAALQELGYQDVSTIETIKENMHFVLPAELR 342 >UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTX4_9ACTO Length = 336 Score = 278 bits (711), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 150/331 (45%), Positives = 204/331 (61%), Gaps = 23/331 (6%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA++ V+ AL +YG PIYVR E+VHN++VV +L GAIF+ ++S Sbjct: 3 KVLLASPRGYCAGVDRAVTAVQRALEVYGQPIYVRKEIVHNKFVVRTLAAAGAIFVNELS 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ ++FSAHGV+ +V EA+ R L V DATCPLV+KVH E R + G + ILIGH Sbjct: 63 EVPSGSRVVFSAHGVAPSVYAEAEQRGLEVIDATCPLVSKVHREARRYANEGYDIILIGH 122 Query: 122 AGHPEVEGTMG------------QYSNPEGGMYLVESPDDVWK----------LTVKNEE 159 GH EVEGT G E ES D L+ + Sbjct: 123 TGHEEVEGTSGVAPEKIHVIDTDWIDTSESATTGTESADTTATGTPPADPLAGLSTDPDA 182 Query: 160 KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLV 219 KL +++QTTLSVD T+ + L++RFP ++ P DDIC+AT NRQ AV+A+A+Q EVV+V Sbjct: 183 KLIWLSQTTLSVDQTAATVARLQRRFPGLISPPSDDICFATQNRQGAVKAMAQQCEVVIV 242 Query: 220 VGSKNSSNSNRLAE-LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 VGS NSSNS RL E Q A+ I+ ++ +W +GVT+GAS P++LV V Sbjct: 243 VGSANSSNSVRLREVAVQAGAGAAYRIEGVHELNPDWFTGASTIGVTSGASVPEVLVTEV 302 Query: 279 VARLQQLGGGEAIPLEGREENIVFEVPKELR 309 + L Q G E ++ +E F +PK LR Sbjct: 303 LEWLAQHGFDEVQMVQTTQETTSFALPKPLR 333 >UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=ISPH_BIFLO Length = 352 Score = 276 bits (707), Expect = 6e-73, Method: Compositional matrix adjust. Identities = 151/326 (46%), Positives = 214/326 (65%), Gaps = 22/326 (6%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGA-----------PIYVRHEVVHNRYVVDSLRE 51 ++LA+PRGFCAGVDRAI V+ L A P+YVR ++VHN++VV+ L Sbjct: 27 VVLADPRGFCAGVDRAILTVQTILKAAEASGKRTREDGLPPVYVRRQIVHNKHVVEDLAG 86 Query: 52 RGAIFIEQISEVPDGAI-----LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 +GA+F+++++E+PD A ++FSAHGVS V+ EA+ R + V DATCPLV KVH EV Sbjct: 87 QGAVFVQELAEIPDAAAQAGIPVVFSAHGVSPVVKAEAERRGMHVVDATCPLVGKVHREV 146 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQ 166 R R G E + IGH GH E G +G+ +PE ++L+E DV L + KL ++Q Sbjct: 147 LRFVREGYEIVYIGHKGHDEAVGVVGE--SPEH-VHLIEHESDVDSLDFAPDTKLVLLSQ 203 Query: 167 TTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSS 226 TTLSVD+T+D I AL+ +FP I P DICYAT+NRQ AV+ +A+Q++ V++VGS NSS Sbjct: 204 TTLSVDETADTIAALKAKFPWIQEPPSSDICYATSNRQAAVKLVAQQSDCVVIVGSANSS 263 Query: 227 NSNRLAELAQR-MGKR--AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 NS RL E+AQ +G+R A+ +DDA ++ W + ++ VG+++GAS PD LV V+ LQ Sbjct: 264 NSVRLMEVAQEGLGERGKAYRVDDASELDPAWFEGLESVGISSGASVPDELVSGVIDALQ 323 Query: 284 QLGGGEAIPLEGREENIVFEVPKELR 309 LG +E +EN+ F +P ELR Sbjct: 324 NLGFTGMKSVETIKENMHFVLPAELR 349 >UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=14 Tax=cellular organisms RepID=ISPH_CHLTB Length = 307 Score = 270 bits (689), Expect = 7e-71, Method: Compositional matrix adjust. Identities = 144/308 (46%), Positives = 204/308 (66%), Gaps = 4/308 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+L +PRGFCAGV RAI VE AL +G PIYV+HE+VHNR+VVD LRE+GAIFIE + Sbjct: 3 KIILCSPRGFCAGVIRAIQTVEVALEKWGRPIYVKHEIVHNRHVVDKLREKGAIFIEDLQ 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP + +IFSAHGV ++R EA R L DATC LVTKVH V +++G ILIG Sbjct: 63 EVPRNSRVIFSAHGVPPSLREEATERGLIAIDATCGLVTKVHSAVKMYAKKGYHIILIGK 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+ G G+ + + +VE+ +V L ++ L ++TQTTLS+DD +D++ AL Sbjct: 123 RKHVEIIGIRGEAPD---QITVVENIAEVEALPFSAQDPLFYVTQTTLSMDDAADIVAAL 179 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + R+P+I ICYAT NRQ A+R + Q + V V+G + SSNSNRL E+A+R G Sbjct: 180 KARYPQIFTLPSSSICYATQNRQGALRNILPQVDFVYVIGDRQSSNSNRLREVAERRGVT 239 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE-GREENI 300 A L++ ++ EE ++ +G+TAGAS P+ +VQ + +LQ+L +I ++ EE+ Sbjct: 240 ARLVNHPDEVTEEILQYSGNIGITAGASTPEDVVQACLMKLQELIPDLSIEMDLFVEEDT 299 Query: 301 VFEVPKEL 308 VF++PKEL Sbjct: 300 VFQLPKEL 307 >UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1NAP1_9BACT Length = 309 Score = 267 bits (683), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 142/307 (46%), Positives = 204/307 (66%), Gaps = 10/307 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I +A P G CAGV RA+ VE L AP+YV HE+VHN ++V+ L+ERG IF E ++ Sbjct: 6 KIFIARPHGMCAGVRRALDTVEAVLKSAPAPVYVLHEIVHNNFIVNRLKERGVIFAETLA 65 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GA+L+FSAHGVS AV EA+ R L DATCPLV + +++ R GE ILIGH Sbjct: 66 EVPEGAVLLFSAHGVSAAVEEEARRRSLRTVDATCPLVKSLQSAASKSFRPGEVLILIGH 125 Query: 122 AGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLT-VKNEEKLSFMTQTTLSVDDTSDVID 179 GHPEVEG +G+ P GG ++++ +V L + + ++QTTL+++ +V+ Sbjct: 126 RGHPEVEGVLGRV--PAGGTVHVISGAAEVPGLPELPAGTPVRALSQTTLNLEAVDEVLA 183 Query: 180 ALRKRFPKI-VGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 ALR R+P++ GP +CYATTNRQ+AVR LA + +L++GS SSNSNRL E+A++ Sbjct: 184 ALRNRWPQLESGP---GVCYATTNRQKAVRQLAARCRTILIIGSPRSSNSNRLREIAEQA 240 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 G RAFLID +++ + + +GV+AGASAP+ LV+ V RL++LG G + P+E E Sbjct: 241 GARAFLIDGPQELPP--LDPSQDIGVSAGASAPEELVEATVERLRRLGYGASEPVEAAVE 298 Query: 299 NIVFEVP 305 + F +P Sbjct: 299 TVAFRLP 305 >UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Leptospira RepID=ISPH_LEPIN Length = 330 Score = 265 bits (678), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 141/310 (45%), Positives = 201/310 (64%), Gaps = 12/310 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I LANPRGFCAGV AIS VE A IYVR E+VHNR VV+ +++ G FI + Sbjct: 22 KIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDLD 81 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 E P+GA +IFSAHGVS +V AK R + + DATCPLVT+VH + AR + + I IGH Sbjct: 82 EAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRK-ARKIKDTHQIIYIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVDDTSDVID 179 GH E GTMG E M+LVES +D+ L + + L+++ QTTLSV DT ++ID Sbjct: 141 EGHDEAIGTMG-----EAEMFLVESLEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIID 195 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K FP + P KDDICYATT RQEAV + ++ + +LV+G+ NSSNS RL +LAQ+ Sbjct: 196 QISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADNSSNSLRLLQLAQKSK 255 Query: 240 KRAFLIDDAKDIQEEWVK--EVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL--EG 295 +F + A D+ +E+++ E+K +G+TAGAS P +LV ++++L+ + L Sbjct: 256 PHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGS 315 Query: 296 REENIVFEVP 305 R++++ F++P Sbjct: 316 RDDSMNFKLP 325 >UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Neorickettsia RepID=ISPH_NEOSM Length = 303 Score = 265 bits (677), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 134/307 (43%), Positives = 212/307 (69%), Gaps = 8/307 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 MQI +A PRGFCAGV+RAI VE A+ Y I+V HE+VHN V+ + RG FIE Sbjct: 1 MQIFVACPRGFCAGVERAIETVEIAIRRYPEKKIFVYHEIVHNSRVIQDFKARGVDFIED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I++V ++LIFSAHGVS+ + KS DL + DATCPLV+K+H EV R + G ++I Sbjct: 61 ITKVEPKSVLIFSAHGVSEEIEKYVKSLDLVLVDATCPLVSKIHREVQRFEKEGFIILVI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G+ H E+ GT+G+ + Y+V+ P+D+ L KL+++TQ+TL+++ TS +I+ Sbjct: 121 GNRNHAEIIGTVGR---TKTQAYIVQDPEDIDNLP-SITGKLAYVTQSTLALEYTSTMIN 176 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ++++FP +VG + D+CYAT NRQEAV+ALA++ +++L+VGS NSSNS L +++ ++ Sbjct: 177 KIKEKFPNVVG--RSDVCYATQNRQEAVKALAKEVDLMLIVGSTNSSNSRNLMQVSSKIC 234 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ-LGGGEAIPLEGREE 298 ++AFLID+ +++ +W + V VG+++GASAP+ILVQ++V+ L++ E + +EE Sbjct: 235 QKAFLIDNYNEVEPDWFEGVDRVGISSGASAPEILVQDLVSFLKKRFPSAEVSDFKFKEE 294 Query: 299 NIVFEVP 305 + F++P Sbjct: 295 KVQFKLP 301 >UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepID=A7AME9_BABBO Length = 419 Score = 249 bits (636), Expect = 9e-65, Method: Compositional matrix adjust. Identities = 140/316 (44%), Positives = 191/316 (60%), Gaps = 5/316 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L PRGFCAGV RAI VE A+ I+G PIYV+HE+VHN +V ++L+++G IFIE I Sbjct: 85 VFLLEPRGFCAGVRRAIETVEEAVRIFGPPIYVKHEIVHNEFVCNTLKKKGVIFIEDIET 144 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VP+G+IL+ SAHGV +V K R+L DA+CPLV KVH+ V + + G + ILIGH Sbjct: 145 VPEGSILVLSAHGVPPSVHEMVKKRNLVEIDASCPLVNKVHVYVRKKAEEGYKIILIGHK 204 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H E GT+G+ + +VE+ DDV +L + L + TQTTLSVDD + D L Sbjct: 205 SHVETIGTLGEAPD---VTTVVETVDDVDRLEYSRDTPLFYATQTTLSVDDCKIIKDRLL 261 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +RFP I ICYATTNRQ AVR ++VLVVGS SSN+NRL + A RA Sbjct: 262 ERFPWIETIPSGSICYATTNRQFAVRDACNFCDLVLVVGSSLSSNANRLVDTANLRNVRA 321 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV- 301 LI +A I EE + + + + ++A AS PD L +VV +L I + + V Sbjct: 322 HLIPNADAITEELIGDARKIALSASASTPDELTADVVKKLAVPPYNYNIEIYHSCDERVP 381 Query: 302 -FEVPKELRVDIREVD 316 + +P+ L + I+E D Sbjct: 382 KWRLPRNLELYIKEHD 397 >UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Mobiluncus mulieris RepID=C2KTB4_9ACTO Length = 374 Score = 244 bits (623), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 144/372 (38%), Positives = 205/372 (55%), Gaps = 64/372 (17%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA+++V+ AL +GAP+YVR E+VHN++VV +L GA+F+ ++ Sbjct: 3 KVLLASPRGYCAGVDRAVTVVQRALERFGAPVYVRKEIVHNKFVVRTLAAAGAVFVSELH 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ +IFSAHGV+ AV EA++R L V DATCPLVTKVH E R + +G + ILIGH Sbjct: 63 EVPSGSRVIFSAHGVAPAVYAEAEARGLKVIDATCPLVTKVHREAKRFADQGYDIILIGH 122 Query: 122 AGHPEVEGTMG---------------------QYSNP------------EGGMYLVESPD 148 GH EVEGT G Q P + G+ ES Sbjct: 123 QGHEEVEGTQGVAPDRIRVIDTNQDVSILTGNQPETPGENPAPSPKERQDFGLAPGESSP 182 Query: 149 DVWKLTVKN-------EEKLSFMTQTTLSVDDTSDVIDALRK------------------ 183 + + V E ++ + T + D T + RK Sbjct: 183 NPARNVVPGSQPELAPHESVNHVNHETAATDATDSATNGKRKMVWLSQTTLSVDQTNETV 242 Query: 184 -----RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 FP + P DIC+AT NRQ AV+A++ + +VV+VVGS NSSNS RL E+A+ Sbjct: 243 ARLKLHFPGLESPPSGDICFATQNRQGAVKAMSPKCDVVIVVGSANSSNSVRLMEVAREA 302 Query: 239 GKRA-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 G A + +D A ++ +W + K VG+T+GAS P++LV V+ L G + P+E E Sbjct: 303 GAGASYRVDGAGELCADWFEGAKTVGLTSGASVPEVLVDEVLQWLAAHGFDDVEPVETLE 362 Query: 298 ENIVFEVPKELR 309 E F +P++LR Sbjct: 363 ETTRFALPRDLR 374 >UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_PLAF7 Length = 535 Score = 238 bits (606), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 127/314 (40%), Positives = 187/314 (59%), Gaps = 5/314 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L NPRGFC GV RAI VE L ++ PIYV+H++VHN V L + GAIFIE +++ Sbjct: 222 LYLINPRGFCKGVSRAIETVEECLKLFKPPIYVKHKIVHNDIVCKKLEKEGAIFIEDLND 281 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VPDG ILI+SAHG+S +R AK + L DATCPLV KVH+ V ++ + ILIG+ Sbjct: 282 VPDGHILIYSAHGISPQIREIAKKKKLIEIDATCPLVNKVHVYVQMKAKENYDIILIGYK 341 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H EV GT Y+ ++VE+ +DV KL +KL ++TQTTLS+DD + ++ L+ Sbjct: 342 NHVEVIGT---YNEAPHCTHIVENVNDVDKLNFPLNKKLFYVTQTTLSMDDCALIVQKLK 398 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +FP I ICYATTNRQ A+ + + ++ +VVGS +SSN+ +L +Q A Sbjct: 399 NKFPHIETIPSGSICYATTNRQTALNKICTKCDLTIVVGSSSSSNAKKLVYSSQIRNVPA 458 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP-LEGREENI- 300 L++ D+ ++ +K V + +T+ AS P+ Q V L + +G EN+ Sbjct: 459 VLLNTVHDLDQQILKNVNKIALTSAASTPEQETQKFVNLLTNPPFNYTLQNFDGAHENVP 518 Query: 301 VFEVPKELRVDIRE 314 +++PK L I+E Sbjct: 519 KWKLPKNLLHMIKE 532 >UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Deinococci RepID=ISPH_THET2 Length = 340 Score = 237 bits (604), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 144/326 (44%), Positives = 197/326 (60%), Gaps = 22/326 (6%) Query: 2 QILLANPRGFCAGVDRAISIVEN---ALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++ LA PRGFCAGV AI VE AL G + V HE+VHNR VV+ L+ +G F+E Sbjct: 9 RVYLARPRGFCAGVVMAIEAVERWAEALKEKGE-LVVYHEIVHNRVVVERLQAKGVHFVE 67 Query: 59 QISEVPDGA-------ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 ++EV ++FSAHG AVR +A LTV DATCPLVTKVH E R ++ Sbjct: 68 DLAEVERLRRERRLADTVVFSAHGHPPAVRRQAAEMGLTVLDATCPLVTKVHTEAKRYAK 127 Query: 112 RGEESILIG-HAGHPEVEGTMGQYSNPEGGMYLV------ESPD--DVWKLTVKNEEKLS 162 G +LIG A H E++GT G+ PE + + + P D + V + E++ Sbjct: 128 EGYWILLIGDSADHQEIKGTYGE--APERTILVAVHTHVGKDPRLADPRTVEVPDPERVV 185 Query: 163 FMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGS 222 +TQTTLSVDDT I L+KRFPK+V P + D+CYAT NRQEAV+ +A + E LV+ S Sbjct: 186 VLTQTTLSVDDTLATIAILKKRFPKLVVPSRKDLCYATQNRQEAVKRIAPKVEAFLVLTS 245 Query: 223 KNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 +SSN RL ELAQ + RA+ ++ ++++ EW++ V+ +G+T+ AS P+ LVQ VVARL Sbjct: 246 PHSSNGMRLLELAQSLVGRAYRLERPEELRPEWLEGVESLGITSAASTPEDLVQGVVARL 305 Query: 283 QQLGGGEAIPLEGREENIVFEVPKEL 308 + G + EG E I F PK L Sbjct: 306 KAQNPGLEVVEEGAWETIAFREPKPL 331 >UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Deinococcus deserti VCD115 RepID=C1CUR9_DEIDV Length = 334 Score = 226 bits (576), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 136/326 (41%), Positives = 185/326 (56%), Gaps = 25/326 (7%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAI-FIEQI 60 +I LA PRGFCAGV AI VE A P+ V H +VHN VV+ LR G + F+E + Sbjct: 4 RIHLAKPRGFCAGVVMAIQAVEKAARTEEKPVTVYHSIVHNHTVVERLRAGGGVHFVEDL 63 Query: 61 SEVP----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + +G +IFSAHG+S VR A+ L DATCPLVTKVH E + +R G Sbjct: 64 DAIEALPENGETVIFSAHGISPVVRERARQLGLATIDATCPLVTKVHTEAKKYAREGYTI 123 Query: 117 ILIG-HAGHPEVEGT-------------MGQYSNPEGGMYLVESPDDVWKLTVKNEEKLS 162 +LIG A H EV GT +GQ N + G+ +D + V + ++ Sbjct: 124 LLIGDSARHQEVIGTRGEAPDHTILVGVLGQAHNEDSGL------NDPHTVEVPDPSRVV 177 Query: 163 FMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGS 222 +TQTTLSVDDT +D LR RFP +V P +D+CYAT NRQ+AV+A+A ++ LV+ S Sbjct: 178 VLTQTTLSVDDTRRTVDVLRSRFPALVVPPSEDLCYATKNRQDAVKAIAPVVDMFLVLTS 237 Query: 223 KNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 +SSN RL ELA+ + RA ++ D+Q + V+ VG+T+ AS PD LVQ VV Sbjct: 238 THSSNGMRLLELARSLCGRAERLETVADLQMLDLSGVRSVGITSAASTPDDLVQAVVEHF 297 Query: 283 QQLGGGEAIPLEGREENIVFEVPKEL 308 + L + EG ENI F P+++ Sbjct: 298 RSLNPLLQVTEEGEWENIEFREPRKI 323 >UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Meiothermus RepID=C1XXH1_9DEIN Length = 343 Score = 219 bits (557), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 138/329 (41%), Positives = 192/329 (58%), Gaps = 27/329 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENA---LAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++ LA PRGFCAGV AI VE A L G + V H +VHN VV L ++G F+E Sbjct: 4 RVYLAKPRGFCAGVVMAIQAVEKAAQELKEEGE-LVVYHAIVHNDVVVKRLEQQGVHFVE 62 Query: 59 QISEV--------PDGAIL----IFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 ++EV GA L +FSAHG+ +R EA R L+ DATCPLVTKVH E Sbjct: 63 DLAEVERLRKERRKAGAKLADTVVFSAHGIPPRLRTEAAQRGLSQIDATCPLVTKVHSEA 122 Query: 107 ARASRRGEESILIG-HAGHPEVEGTMGQYSNPEGGM------YLVESPD--DVWKLTVKN 157 R ++ G +LIG A H E++GT G+ PE + ++ P D ++ V + Sbjct: 123 KRYAKEGYWILLIGDSADHQEIKGTRGE--APERTILVSVHTHVGRDPRLADPRRVEVPD 180 Query: 158 EEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVV 217 EK+ +TQTTLSVDDT I+ L+ RFPK+V P +DD+C+AT NRQ+AV+ +A ++ Sbjct: 181 PEKVVVLTQTTLSVDDTLATIEILKARFPKLVVPSRDDLCFATKNRQDAVKQIAPHVDLF 240 Query: 218 LVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQN 277 LV+ S SSN RL ELA+++ RA I+ D++ EW++ VK VG+T+ AS PD LVQ Sbjct: 241 LVLTSTASSNGMRLLELAKQLVGRAERINTVADLKPEWLEGVKSVGITSAASTPDDLVQE 300 Query: 278 VVARLQQLGGGEAIPLEGREENIVFEVPK 306 VV + + +G E+I F P+ Sbjct: 301 VVGYFRSHNPALEVIEQGEWEDIEFREPR 329 >UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZW7_ACIFD Length = 344 Score = 207 bits (528), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 123/316 (38%), Positives = 185/316 (58%), Gaps = 24/316 (7%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRGFCAGV+RAI + L I+ P+Y HE+VHNR VV++ G +F++ + Sbjct: 5 KVLLAAPRGFCAGVERAIGALGWMLRIFEPPVYCYHEIVHNRLVVEAFEAAGVVFVDDVE 64 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 VP G ++ SAHG + V A+ R V DA CPLVTKVH E+ ++RG + + +GH Sbjct: 65 SVPPGRPVMLSAHGTAPEVLEAARQRCPIVVDAVCPLVTKVHHEIRTRAQRGYQIVYVGH 124 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E G + PE + VE+P++ +T+ + ++ + QTTL+V + + + Sbjct: 125 RGHEEAIGATAE--APE-AVTFVETPEEARAITL-GDGPVALLAQTTLAVPEWEAIAAIV 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA------ 235 + P + P + D+CYATTNRQ AVRALAE+ + ++VVGS NSSN+ L +A Sbjct: 181 ASQTPNLWQPGRSDLCYATTNRQAAVRALAERVDAMVVVGSANSSNTRALERVATSAGVG 240 Query: 236 --QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 +R+ + + L+ + I VGVTAGASA + +V++VVA L G E I + Sbjct: 241 HVERVNRPSELVGPFEGI----------VGVTAGASAAESVVKDVVAALAPRLGVEEISV 290 Query: 294 EGREENIVFEVPKELR 309 EE+ F +P +LR Sbjct: 291 --LEEDEFFPLPPDLR 304 >UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=72 Tax=Bacillales RepID=ISPH_BACC0 Length = 316 Score = 183 bits (465), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 111/292 (38%), Positives = 166/292 (56%), Gaps = 14/292 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M+I+ +PRG+C GV A+ I NA PIY+ +VHN++V D+ E G I ++ Sbjct: 1 MKIVKISPRGYCYGVVDAMVIARNAALDTSLPRPIYILGMIVHNKHVTDAFEEDGIITLD 60 Query: 59 QISEVP-----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 S + D +IF+AHGVS V+ AK + LT DATCP VTK H + G Sbjct: 61 GPSRLDILDKIDSGTVIFTAHGVSPEVKQRAKEKGLTTIDATCPDVTKTHDLIEAKKAEG 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 I IG HPE EG +G + ++L+E DD+ L + +K+ QTT+S D Sbjct: 121 YHVIYIGKKNHPEPEGAVGIAPD---IVHLIERADDLKTLEIPT-DKILVTNQTTMSQWD 176 Query: 174 TSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +++ ++K+FP +IC AT RQEAV A+ A++ +VVG S+NSNRLA+ Sbjct: 177 VQHLMEDIQKKFP--TAEFHKEICLATQVRQEAVAKQADVADLTIVVGDPKSNNSNRLAQ 234 Query: 234 LAQRM-GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 ++Q + G +A+ + D +I EW++ V+ V VTAGAS P + + V+A L+Q Sbjct: 235 VSQEIAGTKAYRVADVSEINLEWLQGVENVAVTAGASTPTPITKEVIAFLEQ 286 >UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase homolog n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=ISPH_BUCBP Length = 221 Score = 182 bits (463), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 80/214 (37%), Positives = 132/214 (61%), Gaps = 1/214 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+ILL NPR FC RA+SIV AL +G IYV H++VHN Y++++L+ +G IF + I Sbjct: 1 MKILLENPRSFCVETKRALSIVNLALKTWGKLIYVNHKIVHNNYIINNLKLKGVIFSKNI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + + + + L+ S H V ++ + + + DATCPLV KVH ++ ++ ILI Sbjct: 61 NSILESSKLMLSKHSVPNKIKKTTLEKKIFIIDATCPLVKKVHKKIHYKNKNTYNVILIE 120 Query: 121 HAGHPEVEGTMGQY-SNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 ++ HP+++GT+ +Y N + +Y+V+S KLT+KN Q TLS + +I Sbjct: 121 NSQHPKIQGTLERYQKNLKNSIYIVKSKKYAIKLTIKNTRNSIITAQITLSSEKIYPIIT 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ 213 LRK+FP I+ +++ICYAT NR+ A++ ++++ Sbjct: 181 ILRKKFPAIINSHENNICYATINRKTAIKHISKK 214 >UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7 Tax=Clostridiales RepID=A3DDC0_CLOTH Length = 694 Score = 178 bits (451), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 100/286 (34%), Positives = 165/286 (57%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV A+ V N L PIY ++HN VVD +G I+ I Sbjct: 1 MEIIVAKSAGFCFGVSNAVKTVNNLLENQKEPIYTYGPIIHNAQVVDLFTSKGVKKIDDI 60 Query: 61 SEV-PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 E P+G I+I AHGV+ + + + L + DATCP V K+H V S G + I++ Sbjct: 61 DEAEPNGHIVI-RAHGVTPDIYKKISDKGLILEDATCPYVKKIHNLVKEKSEEGYKIIIV 119 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G +N Y+V+S DDV K ++EK+ + QTT++ + +V Sbjct: 120 GDRNHPEVIGINGWCNNQ---AYIVDSVDDVEKFPT-SDEKVCVVAQTTITNEKWLEVNT 175 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 AL+K+F I+ + D IC AT+ RQ +A+ ++++++G KNSSN+ +L ++ ++ Sbjct: 176 ALKKKFKNIL--KFDTICSATSRRQNEAEEIAKNVDMMIIIGGKNSSNTQKLYDICKKHC 233 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ + D+ +K++K VG++AGAS PD +++ V+ ++ +L Sbjct: 234 NLTYKIETSGDLPPVDIKKIKKVGISAGASTPDWVIEEVIKKMSEL 279 >UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4 Tax=Veillonellaceae RepID=A1HTW2_9FIRM Length = 655 Score = 177 bits (450), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 102/286 (35%), Positives = 164/286 (57%), Gaps = 12/286 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+LA RGFC GV RAI E A A G P+Y ++HN +V L E+G + Sbjct: 1 MKIILAEYRGFCYGVKRAI---ETAYACIGQGPVYTLGPIIHNPQLVQRLSEQGVVMANT 57 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + ++P G ++I S HGV V ++A++R L V DATCP V K + + +G ++ Sbjct: 58 LEQIPAGRVIIRS-HGVGPEVYDQARARSLEVVDATCPHVRKAQQAARQLAEKGYYVAVV 116 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+ + + +VE+P D L E+L + QTT + D + ++D Sbjct: 117 GEPNHPEVKSIVAWAGER---VTVVETPADAQNLPY--HEQLGVVAQTTFASDQFNTIVD 171 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+ + +I R IC AT RQ+A LA + +V++VVG KNS+N++RLAEL + G Sbjct: 172 ILKTKCREIEVSRT--ICTATDQRQQAAIKLARKVDVMVVVGGKNSANTSRLAELCRLQG 229 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++ A++++ +W V+ VG+TAGAS PD +++ V +++Q+ Sbjct: 230 CPTYHVETAQELKIDWFTGVQTVGITAGASTPDWIIEEVYSKMQEF 275 >UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Leptospirillum RepID=A3ERP9_9BACT Length = 302 Score = 177 bits (448), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 99/285 (34%), Positives = 163/285 (57%), Gaps = 7/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I L G C GV RAI + P+++ HE+VHN +VV L ERG ++++ Sbjct: 1 MDIFLPEYAGVCVGVKRAIKMAHKTAEEATGPVFILHEIVHNTHVVKDLSERGVKSVDEV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G LI SAHGV+ V +A+SR+L V D TCPLV K+H V + + L+G Sbjct: 61 KEVDKGT-LIISAHGVAPEVIADARSRNLEVVDTTCPLVWKIHRIVKALAEKNYTIFLLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G + +++ +++ L + E ++ ++QTT S+ +++D Sbjct: 120 ERNHDEVMGVQGVAKD---HIHIFHKKEEIAHLPL-TEGPVALVSQTTQSIKYFDEILDL 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L +R+P++ + IC AT RQ + A+A +V++ VGS +S+NS RL E++ + + Sbjct: 176 LLERYPQL--EIHNTICDATEKRQTSALAIAGDMDVMITVGSMSSANSRRLQEVSAGLCR 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++L+D A ++ + W K + VGVTAGAS P+ L++ V+ +L ++ Sbjct: 234 ASYLVDSANEVSDTWFKGGERVGVTAGASTPEWLIEGVIEKLMEI 278 >UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Firmicutes RepID=ISPH_LISMC Length = 331 Score = 176 bits (445), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 113/316 (35%), Positives = 182/316 (57%), Gaps = 17/316 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFI- 57 M+I+ +PRG+C GV A+ I +NA PI++ +VHN++V D+ G + Sbjct: 1 MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVD 60 Query: 58 ----EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 E+I + +IF+AHGVS +V+ +A ++ LT DATCP V + + G Sbjct: 61 GANREEILDKITTGTVIFTAHGVSPSVKAKAAAKGLTTIDATCPDVLHTYNLILEKQAAG 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 E I IG GHPE EG G + P+ ++LVE+ D+ L++ ++ + QTT+S D Sbjct: 121 YEIIYIGKKGHPEPEGAYG--TAPD-VVHLVETKADIDALSLLSDN-IFVTNQTTMSKWD 176 Query: 174 TSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +D++D ++++FPK + + +IC AT RQEAV A+ A++ +VVG S+N+ RLA+ Sbjct: 177 VADLMDYIKEKFPKAI--QHQEICMATQVRQEAVAVQAKGADLTIVVGDPRSNNTARLAQ 234 Query: 234 LA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 ++ ++ G +A+ I D ++ EW+K+ K V VTAGAS P LV+ V+ L+Q + Sbjct: 235 VSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKTT 294 Query: 293 LEGREENIVFE--VPK 306 + R N FE +PK Sbjct: 295 WK-RAHNKDFERILPK 309 >UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipelotrichaceae RepID=A8RBC4_9FIRM Length = 303 Score = 171 bits (433), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 111/310 (35%), Positives = 164/310 (52%), Gaps = 30/310 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAISI + Y IYV +VHNRYV+ +L+ ++ Sbjct: 1 MEIIKVVPRGYCKGVTRAISIAKETAQKYPDKSIYVLGMLVHNRYVMQALKALNIHAVDD 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + E+P I+IF+AHG++ V +AK L DA+CP V K V Sbjct: 61 PHKSRLQLLDELPKDCIVIFTAHGIAPQVIEKAKQMGLICIDASCPDVVKTQQLVYEKLN 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G + IG HPE E + S+ ++L+ S +D+ T+ N + QTT+S+ Sbjct: 121 EGYDVFYIGKRSHPEAEAVLSLSSH----VHLITSKEDID--TITNVTNVFVTNQTTMSI 174 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQA-EVVLVVGSKNSSNSNR 230 DT + + +++++P V ++IC AT RQEAV L QA +V+ VVG K+S+NSNR Sbjct: 175 FDTQALFNYIKQKYPNAV--LCEEICNATRIRQEAVANLKNQAIDVLYVVGDKHSNNSNR 232 Query: 231 LAELAQRMG-KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 LA++AQ +LIDD DI+E + K +G+T+GAS P L V+ Sbjct: 233 LAQIAQENKIANVYLIDDVNDIEEAQFAKAKRIGITSGASTPTYLTSQVIHY-------- 284 Query: 290 AIPLEGREEN 299 LEG E+N Sbjct: 285 ---LEGYEQN 291 >UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonella RepID=D1BMA5_VEIPT Length = 632 Score = 170 bits (431), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 103/298 (34%), Positives = 166/298 (55%), Gaps = 11/298 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV RA+ + A G Y ++HN VV L ++G ++++ Sbjct: 1 MEIILAENHGFCYGVKRAVEMANEAANNDGKS-YTLGPIIHNPQVVGRLEDKGVSPVQEV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S++ +G ++I S HGV A+ EA+ + L V DATCP V K + G +++G Sbjct: 60 SDIVEGTMIIRS-HGVGPAIYEEAEEKGLHVVDATCPYVKKAQQDAKSVIDEGMTLVILG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ ++ ++N EG ++E + KL V EK+ + QTT S + +ID Sbjct: 119 EKNHPEVK-SINLWANNEG--IIIEDEESAQKLQVV--EKMGVVVQTTFSQFKFNSIIDI 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K+ + + IC AT RQ + LA ++++V+G KNS N+NRLAE+ + +G Sbjct: 174 LEKKSKNLKVFKT--ICNATQERQNSAVDLARNVDLMIVIGGKNSGNTNRLAEVCRDVGC 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + I+ + ++Q EW V+ VGVTAGAS PD +++ V+ ++ E + EG+EE Sbjct: 232 ATYHIETSTELQLEWFNRVQTVGVTAGASTPDWIIKEVIETMKDF--AELLAAEGQEE 287 >UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Aquificales RepID=ISPH_AQUAE Length = 289 Score = 169 bits (429), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 95/291 (32%), Positives = 164/291 (56%), Gaps = 9/291 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I++A GFC GV RA+ + E +L +Y ++HN V+ L+ G +F Q E Sbjct: 4 IIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLG-VFPSQGEE 62 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 +G +I +HG+ + + L V DATCP V VH V + +R G +L+G Sbjct: 63 FKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVGEK 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID--A 180 HPEV GT+G G +VE+ +D+ + E++ + QTT + + +V+ A Sbjct: 123 NHPEVIGTLGYLRACNGKGIVVETLEDIGEAL--KHERVGIVAQTTQNEEFFKEVVGEIA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + K++ + IC AT+ RQE+V+ LA + +V++++G KNS N+ RL +++ + Sbjct: 181 LWVKEVKVI----NTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNP 236 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 + I+ A+++Q EW + VK VG++AGAS PD +++ V +R+Q++ G+ + Sbjct: 237 NTYHIETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLV 287 >UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Beggiatoa sp. PS RepID=A7C5H7_9GAMM Length = 214 Score = 167 bits (423), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 80/145 (55%), Positives = 109/145 (75%) Query: 141 MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYAT 200 M+++ +P++V L+VKN ++L+++TQTTLS+DDT DVI AL RFP I GP +DICYAT Sbjct: 5 MHVLCTPEEVMALSVKNPKQLAYVTQTTLSLDDTRDVIAALTTRFPNIKGPALNDICYAT 64 Query: 201 TNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVK 260 NRQ AVR LA EV+LVVG+ NSSNSNRL E+ + G +A+LI+DA+D+Q +W Sbjct: 65 QNRQNAVRQLANDVEVLLVVGANNSSNSNRLREVGTQAGVQAYLIEDAEDLQPQWFANRP 124 Query: 261 CVGVTAGASAPDILVQNVVARLQQL 285 VG+TAGASAP++LV+ V+ RL Sbjct: 125 TVGITAGASAPEVLVEGVLQRLNNF 149 >UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=51 Tax=Epsilonproteobacteria RepID=ISPH_CAMFF Length = 279 Score = 165 bits (418), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 98/288 (34%), Positives = 163/288 (56%), Gaps = 17/288 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENA--LAIYGAPIYVRHEVVHNRYVVDSLRERGAI-FI 57 M+I LA GFC GV RAI I EN+ + G E++HN +D L+ + + Sbjct: 1 MKIELAKSYGFCFGVKRAIKIAENSKNASTIG-------ELIHNSLEIDRLKNNFNVKTL 53 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + ISE+ + I HG+++ KSRD+ + DATCP VTK V + S G E + Sbjct: 54 KDISELKNEKKAIIRTHGITKEGLANLKSRDVEIIDATCPFVTKPQQIVEKMSSEGYEIV 113 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 G HPEV+G M YS+ + L ES + TVK K++ ++QTT ++ + + Sbjct: 114 FFGDINHPEVKGVMS-YSSKNVYVILDESELE----TVKLPSKIAVVSQTTKKIEKFTKI 168 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + L +R ++ + IC AT QEAVR L+ +A+V++++G KNSSN+ +L +++ Sbjct: 169 VSYLMQRVKEV--RVFNTICNATLENQEAVRELSSRADVMVIIGGKNSSNTKQLYLISKN 226 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++LI+ +++ +W + K G++AGAS P+ ++QNV+ +L+ L Sbjct: 227 LCPDSYLIESENELELKWFQNKKLCGISAGASTPEWVIQNVINKLENL 274 >UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridia RepID=A4J3N5_DESRM Length = 672 Score = 165 bits (417), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 93/285 (32%), Positives = 160/285 (56%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RAI + + IY ++HN VV +L E G I I Sbjct: 1 MRIKLASKAGFCYGVKRAIDLALSTAKEKAGNIYTLGPLIHNPQVVQNLAENGICEINDI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV +G ++I S HGV + A+ + L V DATCP V + + +G ++G Sbjct: 61 GEVKEGTVIIRS-HGVGPEIIQAAREKGLKVLDATCPFVARAQKYAHEMAAQGIPVYILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEV+G +G EG ++++P ++ ++ K+ + QTT + + +++A Sbjct: 120 DPGHPEVQGILGWT---EGKGSVIDNPSEITRV---EHPKVGVVAQTTQPLSNFQALLEA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + ++ ++ IC+AT RQ A LA + +V++VVG KNS+N+ +LA++ Q G Sbjct: 174 LQNQGVEV--DARNTICHATGERQRAAMELAREVDVMVVVGGKNSANTKKLAKICQETGT 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++ A+++++EW + VG+TAGAS PD +++ V R+ ++ Sbjct: 232 PTYHVESARELRKEWFLGHEIVGLTAGASTPDAIIEEVKKRMNEM 276 >UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GDV0_9FIRM Length = 678 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 98/285 (34%), Positives = 163/285 (57%), Gaps = 10/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL-AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M++++A GFC GV +A V+ AL A +Y + HN ++D LRE G IF++ Sbjct: 1 MKVIVAEHAGFCGGVKKA---VKQALDASRQGRVYALGPLAHNDSLLDKLREEGVIFVDD 57 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 ++EVP GA ++ +HG V +A+ R L + DATC V K+ VAR G++ I++ Sbjct: 58 LAEVPHGATVVIRSHGERPEVFRQAEERGLQIVDATCTFVGKLQTLVARLIEEGKQVIVL 117 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVI 178 G HPE++G +G + ++ + + +L N EK ++ + QTT +++ Sbjct: 118 GDPTHPEIKGVLGWGRDQP---IVLTADGSISELEGLNREKPVALVAQTTQRQSILAEIG 174 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + L+ P V + IC AT RQEA R LA ++++VVG KNS+N+ +LA++ + Sbjct: 175 EKLKAIVP--VVEIYNTICQATALRQEAARNLAYDVDLMVVVGGKNSANTRKLADVCRST 232 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 G R + +A ++ E +KEV+ VGVTAGAS PD ++ V+ +++ Sbjct: 233 GVRTIAVSEAHELDAEQLKEVRTVGVTAGASTPDWTIKEVIGKME 277 >UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_GEOBB Length = 283 Score = 163 bits (412), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 103/285 (36%), Positives = 152/285 (53%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ++LA GFC GV RA + A I G+ Y ++H+ VV L E G I ++ + Sbjct: 1 MQVILAKHAGFCFGVKRATQLAFQAANI-GSETYTLGPIIHSPQVVQRLEEMGVIPVDNV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEV G +I +HGV+ A +L V DATCP V K VA S+ G + +++G Sbjct: 60 SEVETGGTIIIRSHGVAAEELEAAVRANLEVVDATCPFVKKAQEHVATLSKEGYDIVVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + S G +Y+V S DV +L K+ + QTT S + +V+ A Sbjct: 120 DAVHPEVQGIV---SYAAGRVYVVSSHKDVERL--PRMSKIGVVAQTTQSFEHLHEVVAA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 R + + IC AT RQE + LA + ++V+G NS+N+ RLA++ + Sbjct: 175 CLARGGE--ARVYNTICDATAVRQEEAKKLAGAVDCMVVIGGFNSANTMRLAQICLELLP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R ++ A I E+W K VK VGVTAGAS P ++ V+ R+ + Sbjct: 233 RTHHVETASQIDEQWFKGVKKVGVTAGASTPKWIIDEVIDRISAI 277 >UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FZU7_9CLOT Length = 280 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 92/286 (32%), Positives = 160/286 (55%), Gaps = 7/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAI-YGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I ++ GFC GV RA+ + L + IY ++HN+ V+ ERG + + Sbjct: 1 MNIKISEKAGFCFGVKRAMGLAWRELCEEHDKQIYALGPLIHNKQAVEKYEERGLVTADD 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I E+P +I +HGVS+++ + A ++L V D TCP V K+H V +G++ ILI Sbjct: 61 IEEIPSDVKMIIRSHGVSKSIYDRADEKELEVVDTTCPFVKKIHDIVKENYDKGKKIILI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G +N ++++ D+ +L + E + QTT++++ +++D Sbjct: 121 GDKNHPEVIGINGWCNN---SAIIIKTIDEAKELELDPEVDYCSVAQTTMNLEVYGNMVD 177 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+++ KI + IC +T RQEA R LA + + ++V+G K+SSN+ +L + + + Sbjct: 178 ILKQKSDKI--DFNNTICSSTKARQEAARELASEMDCMVVIGGKHSSNTQKLVGICKEVC 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ D+ E +K+ + VG+TAGAS PD ++ +++ L+ L Sbjct: 236 P-TFAIETRDDLDVEEIKKYENVGITAGASTPDWIIDDIIEYLKSL 280 >UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium MedeBAC82F10 RepID=Q4PKE9_9BACT Length = 191 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 83/193 (43%), Positives = 130/193 (67%), Gaps = 3/193 (1%) Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 +IGH GHPEVEGT GQ + + LV+ +DV KL +++K++++TQTTLSV DT ++ Sbjct: 1 MIGHEGHPEVEGTAGQLQDI-SKLTLVQELNDVEKLYFPSDQKIAYITQTTLSVFDTQEI 59 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 +DAL K+FP+I+ P+K DICYAT+NRQ +VR +A+ + V+G+ NSSNS RL E A++ Sbjct: 60 VDALEKKFPEILAPKKSDICYATSNRQTSVREMAKNVDAFFVIGAFNSSNSIRLVETAKK 119 Query: 238 MG-KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 G + + LI++ D + + + + +G+TA ASAP+ + + R+++ E I + Sbjct: 120 FGCEDSELIENIDDFDYQKLNQYQSIGLTASASAPEEQLNLFIDRVKENFSPEVIDFK-E 178 Query: 297 EENIVFEVPKELR 309 +ENIVF+VP L Sbjct: 179 DENIVFKVPNFLN 191 >UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonellaceae RepID=D2RKJ8_ACIFE Length = 680 Score = 161 bits (407), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 95/288 (32%), Positives = 159/288 (55%), Gaps = 12/288 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A+P GFC GV RAI++ E Y I E+VHN VV+ L+++G E++ Sbjct: 1 MKIYVADPCGFCYGVKRAINVAEVQAKGYNDSIATLGELVHNPRVVEKLKQQGVECKEKL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G +IF +HGV A+ EA+ R+L V DATCP V K A + G I++G Sbjct: 61 AQFAAGDTVIFRSHGVGPALYEEARQRELNVIDATCPHVRKAQKTAAELAGEGRFVIIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ ++ ++ + ++E+ DD+ L K+ K ++QTT + + ++ Sbjct: 121 EKRHPEVQ-SIKAWAGSDS--VVIETSDDLGSLPEKD--KFGVVSQTTFEAEKFNLLLRM 175 Query: 181 LRKRFP---KIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 +++ P K+V IC AT RQ A R LA + + V G KNS+N+ L ELA+ Sbjct: 176 AQEKRPGDYKVV----RTICTATAERQAAARQLAGKTDAFFVFGGKNSANTRHLWELARE 231 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + R++L+ DA +I + + +G+TAGAS P +++ + ++ + Sbjct: 232 INPRSYLLQDASEITGPMLAGAQKIGITAGASTPQEIIEEAIGTMETM 279 >UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collinsella RepID=B6GBX2_9ACTN Length = 283 Score = 160 bits (405), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 98/285 (34%), Positives = 151/285 (52%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + I +A G C GV+RA+++ A P+ ++HN VV L G +++ Sbjct: 3 LTIEVARHAGVCYGVERALTLAAEAARESRGPVRTLGPLIHNPLVVSELEHAGVTVADRV 62 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV D +I AHGV V + A+ LTV DATCP V KVHM + R G + I++G Sbjct: 63 EEV-DAGTVIIRAHGVVPQVVDRAERLGLTVLDATCPYVKKVHMAAEKLVREGYQLIVVG 121 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 +GHPEVEG MG +V +P D+ + + K+ + QTT +V S ++ A Sbjct: 122 ESGHPEVEGIMGHADER---ARVVSTPADLDAIELSR--KVGVVVQTTQTVGALSSIVSA 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R ++ + IC AT RQ++ LA + +V++VVG KNS N+ RLA++ Q Sbjct: 177 LLSRTSEL--RVINTICAATQERQDSAAELAARVDVMIVVGGKNSGNTRRLAQICQMGCA 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 I+D+ +++ W V+ +GVTAGAS P + V +++ L Sbjct: 235 HTHHIEDSSELEASWFTGVEHIGVTAGASTPAAHIDRAVEKIRAL 279 >UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Bacteria RepID=ISPH_THEP3 Length = 288 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 95/290 (32%), Positives = 162/290 (55%), Gaps = 10/290 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAI-YGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+IL+A GFC GV RAI + G IY E++HN V+ L ++G IE+ Sbjct: 1 MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEE 60 Query: 60 --ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + ++ +G LI +HGVS+ + + + + V D TCP V KV V +G I Sbjct: 61 EELDKLTEGDKLIIRSHGVSKKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSII 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 ++G HPEV G G + Y+V S ++ ++L EK + QTTL D+ Sbjct: 121 IVGDRNHPEVIGVNGWCDDT---AYVVNSIEEAYELP--QLEKACAVAQTTLIEKHWKDI 175 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 ++ ++ + ++ + IC AT RQ+A L+++ +V+ V+G K+SSN+ +L ++ ++ Sbjct: 176 LEVIKLKVKDLIFF--NTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEK 233 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K F I+DA+++ E VK+ + +GVTAGAS PD ++++V+ +++ L G Sbjct: 234 NCKNTFHIEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKG 283 >UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196B3D1 Length = 324 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 101/287 (35%), Positives = 166/287 (57%), Gaps = 21/287 (7%) Query: 8 PRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS------ 61 PRG+C GV RAI+IV+ + G PI V +VHN+++VD+L++RGAI IE S Sbjct: 29 PRGYCKGVIRAINIVKETIEQPG-PITVLGMIVHNQFIVDALKKRGAITIEDASKTRMEL 87 Query: 62 --EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 E+ +G ++I +AHG V +AKS+ L V DATC V K H + +RG++ + I Sbjct: 88 LDEINEGTVII-TAHGAGDCVIEKAKSKGLNVVDATCLDVIKTHTLIKEQLKRGKDVLYI 146 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMT-QTTLSVDDTSDVI 178 G HPE EG + +PE ++L+ S D+ L +++K MT QTT+S+ D D+ Sbjct: 147 GKKNHPEAEGAL--LIDPE-HIHLITSKKDLETL---DKDKHYVMTNQTTMSLYDVYDLC 200 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA-QR 237 + ++ + + C AT RQEA+ + E ++V++VG +S+N+ +LA ++ ++ Sbjct: 201 EYAKEILDVEI---MKETCSATQIRQEAIAKMDEDIDLVIIVGDPHSNNTKKLASISMEK 257 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 K +I +++ W+K K VGV++GAS P +L ++ L+Q Sbjct: 258 AHKDTKMIGSLEELDLSWLKGKKHVGVSSGASTPTVLTNQIIDFLKQ 304 >UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2ASB2_STRRD Length = 420 Score = 158 bits (399), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 96/285 (33%), Positives = 155/285 (54%), Gaps = 4/285 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA R C G RA+ I + A G ++ V + + +L G + + Sbjct: 118 RVLLAGTRPACPGARRALEITRDT-AGGGQAVFSYGPVTDDPHQAGALTREGVTTVTDLD 176 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +P+GA ++F AHGVS A+R EA +R LT+ DATCPLV H EVAR + RG+ +++IG Sbjct: 177 RLPEGAGVVFPAHGVSLALRAEAAARGLTIIDATCPLVAAAHAEVARFTERGDLTVVIGR 236 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 +G V +GQ PE LVES DV +L + E +S++ QT + V+ + V+ AL Sbjct: 237 SGDAAVSAVLGQ--APE-STVLVESAADVERLRPADPEAISYLVQTGIPVEQATPVVAAL 293 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R RFP + GP D CY ++R AV ++ ++++L+ + ++ + LA+ G Sbjct: 294 RARFPALRGPDPGDFCYHASDRASAVASITGASDLLLIAAGSHCPDARHVVRLAEPAGVP 353 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 A ++ D+ + ++E V +T+ SAP L + +V L LG Sbjct: 354 AQVVTGVADLCPDRLREAATVALTSARSAPAGLSEQIVTILSGLG 398 >UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Clostridiaceae RepID=ISPH_CLOD6 Length = 279 Score = 157 bits (398), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 86/285 (30%), Positives = 155/285 (54%), Gaps = 6/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A GFC GV RA+ + + + + IY ++HN+ V E+G + +I Sbjct: 1 MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQAVAKYEEKGLKTVNEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P+ +I +HGV + + EAK + L + D TCP V K+H V+ +G E I+IG Sbjct: 61 DTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKIHTVVSEYHNKGYEIIVIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G G N ++++ + + + N ++ + QTT++ + +++ Sbjct: 121 DMKHPEVIGINGWCEN---SAIIIKTLEQMENMEFDNSKRYCLVAQTTINPELYISIVNK 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +IV D IC AT RQE+ + LA++ + ++V+G K+SSN+ +L ++ + + Sbjct: 178 LSDKLEEIV--FNDTICSATKTRQESAKELAKEVDCMIVIGGKHSSNTQKLVKVCEDLVP 235 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ ++ +K+ K +G+TAGAS P+ +++ VV L+ L Sbjct: 236 -TFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFLENL 279 >UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FLP4_DESAA Length = 576 Score = 156 bits (394), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 154/280 (55%), Gaps = 12/280 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC GV RA+ +V + P+Y ++HN V+ L E+G +E+I Sbjct: 1 MKITIAKTSGFCMGVRRAVEMVLDTANRVKGPVYTFGPLIHNPQVMHMLAEKGVEVLEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G +LI AHGV+ R ++ TV DATCP V KV + + G I++G Sbjct: 61 PEKGEGTVLI-RAHGVTPETRGRLEAAGFTVIDATCPRVIKVQRLLDKYQAEGYTPIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV G +G + G Y+V S ++ L + EK + QTT ++++A Sbjct: 120 DADHPEVIGLVG---HARGHAYVVRSREE--ALNLPKGEKAVLVAQTTQDQVLYLNILEA 174 Query: 181 LRKRFPKIVGPRKD--DICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 +R+RF +I KD IC +T RQE R LA Q E ++VVG K+S N+ RLA++A Sbjct: 175 VRERFDEI----KDFNTICDSTARRQEEARGLAHQVEAMVVVGGKSSGNTQRLAQIAAGS 230 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 G F ++ K++ + ++ VG+TAGAS P+ +++ V Sbjct: 231 GVPTFHVETEKELDVTKFQGMEHVGITAGASTPNWIIRRV 270 >UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y3T0_9BACT Length = 293 Score = 154 bits (390), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 98/296 (33%), Positives = 146/296 (49%), Gaps = 20/296 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL+A P G C GV RAI VE ALA AP+Y +HN V+ L++ G ++ Sbjct: 1 MKILVAAPTGLCFGVKRAIGFVEKALA-QTAPVYALGSPIHNPQEVERLQKMGLRVVQSE 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+P GA + AHG + V + R+++V D TCP V S G +++G Sbjct: 60 TEIPAGATALIRAHGAAPGVLENLRKRNVSVIDGTCPFVRAAQGHARELSEAGYHVLILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVES--PDDVWKLTVKNEEKLSFMTQTT-------LSV 171 + HPE G G P + + S ++K +VK KL ++QTT + Sbjct: 120 NEKHPETVGIRGYVRGPSTVISTIPSLFSSTIFKSSVKIH-KLGLVSQTTQEESLLAEAA 178 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 V D LR + IC AT RQEAVR LA Q E ++V+G NS+N+ +L Sbjct: 179 KAALGVADELRI---------YNTICRATIERQEAVRRLASQVEGMIVIGGHNSANTGKL 229 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 +A+ A I+ A + WV E + +G+ AGAS PD L++ + + + G Sbjct: 230 CRIARDSSCDAVWIEHAGQLDRRWVLEKRVIGIAAGASTPDWLIEQLHNAIHNIAG 285 >UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Bacteria RepID=C3RLQ9_9MOLU Length = 303 Score = 153 bits (386), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 93/296 (31%), Positives = 161/296 (54%), Gaps = 23/296 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLR--------ER 52 M++ PRG+C GV RAI + + + +Y+ +VHN+Y+VD+L ++ Sbjct: 1 MKVYPITPRGYCKGVVRAIELAKKQA--HQDDVYILGMIVHNQYIVDALNNLGVKTIDKK 58 Query: 53 GAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 GA E + +V G ++I +AHG S V +A S+++ V +ATCP V K H + + Sbjct: 59 GASREELLDQVSQGTVII-TAHGASHNVIKKAHSKNIQVINATCPDVIKTHDLIKNYLNQ 117 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFM--TQTTLS 170 G E + IG AGHPE EG + S ++L+E+ D L + L+++ QTT+S Sbjct: 118 GIEILYIGKAGHPESEGAL---SIDPAHIHLIENKTDFENL----DPNLNYVITNQTTMS 170 Query: 171 VDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 + D D+ + + + ++ + + C ATT RQEA+ + ++ +V+ +VG +S+N+ + Sbjct: 171 LYDVYDLCEYAKTKLNNLIVAK--ETCQATTVRQEAIAKINDEVDVIFIVGDPHSNNTKK 228 Query: 231 LAELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 LA +A ++ K ++I+ DI +KE V++GAS P L V+ L+Q Sbjct: 229 LASIAHEKANKDTYMIESVNDIDISMLKEKHAAAVSSGASTPTYLTNQVIEYLRQF 284 >UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Desulfuromonadales RepID=ISPH_GEOLS Length = 280 Score = 153 bits (386), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 99/285 (34%), Positives = 153/285 (53%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA + A A + ++H+ VV+ L E G ++ + Sbjct: 1 MKVILAKRAGFCFGVKRATQMAFEA-AGKDQKTFTLGPIIHSPQVVNKLEEMGVGVVKDL 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S V +G ++I S HGV + +EA + L V DATCP V K V S G + +++G Sbjct: 60 SGVSNGTVIIRS-HGVLASEMDEAHQKQLEVVDATCPFVKKAQEHVQYLSEAGYDVLVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + S + +Y+V S D V +L K+ + QTT S D+ V+ Sbjct: 119 DADHPEVQGIV---SYGKEKVYVVASGDQVKQL--PKMGKMGVVAQTTQSFDNLKSVVTE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R ++ + IC AT RQ+ LA+Q + ++V+G NS+N+ RLAE+ + Sbjct: 174 CLRRGGEV--RVYNTICDATAVRQQEATELAQQVDCMIVIGGFNSANTRRLAEICTEIQP 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R + I+ A +I W + V VGVTAGAS P ++ V+ RL Q+ Sbjct: 232 RTYHIETAAEIDCSWFQGVDTVGVTAGASTPKWIIDEVMNRLDQV 276 >UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KIS2_9FIRM Length = 275 Score = 153 bits (386), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 103/284 (36%), Positives = 159/284 (55%), Gaps = 12/284 (4%) Query: 1 MQILLANPRGFCAGVDRAISIV-ENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+++LA+ GFC GV RAI I ENA A A ++HN +VD LR G +++ Sbjct: 1 MEVILADYLGFCYGVKRAIKIARENASADGTACTL--GPIIHNPQMVDRLRREGVGSVDR 58 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + E+ G ++I S HGV AV +EAK+R L V DATCP V K + G ++I Sbjct: 59 LEEMEKGTVIIRS-HGVGPAVYDEAKARGLEVVDATCPHVKKAQLSAKELVDEGYSVVII 117 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+ ++ ++S+ G ++E+ D+ V+ KL + QTT S ++ Sbjct: 118 GEKEHPEVK-SIFEWSS--GKAQIIETEDEA--EAVEPCGKLGIVCQTTFSGARFRQIVM 172 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L ++ I R IC AT RQ A LA + +++LV+G KNS+N+ RLA+L Sbjct: 173 RLLEKSRDIRILRT--ICTATDQRQAAAIDLASKVDLMLVIGGKNSANTTRLAQLCSEKC 230 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 + I+ A ++Q+EW ++K +G+TAGAS PD +++ V + Q Sbjct: 231 -LTYHIETAAELQDEWFDKIKKIGITAGASTPDWIIKEVYKKCQ 273 >UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A4N7_NATTJ Length = 705 Score = 152 bits (385), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 92/297 (30%), Positives = 159/297 (53%), Gaps = 19/297 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGA---PIYVRHEVVHNRYVVDSLRERGAIFI 57 M+IL+A GFC+GV+RA+ A+ + ++ +VHN+ V+ +L E+G I Sbjct: 1 MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGII 60 Query: 58 EQISEVPDGAIL--------IFSAHGVS-QAVRNEAKSRDLTVFDATCPLVTKVHMEVAR 108 E ++++ L + +HGV + + + V DATCP V KV + ++ Sbjct: 61 ENLTQLQSKKCLSEETNNYVVIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASK 120 Query: 109 ASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTT 168 + G + ++G HPEV+G N ++E P+ V + + N K + + QTT Sbjct: 121 LYQDGYQIFIVGDPNHPEVKGIKEWTDN---NAIVIEKPEQVNDIEISN--KTAVVAQTT 175 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 L + +++++ + R P + + IC AT RQ A + LA Q +V++VVG NSSN+ Sbjct: 176 LREEKFNEIVEKILDRNPNTI--VHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNT 233 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +L ELA + G + I+ AK+++ +W K +GVTAGAS PD ++ VV ++++ Sbjct: 234 KKLKELAVKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREF 290 >UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AXA2_SYNWW Length = 687 Score = 152 bits (385), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 104/285 (36%), Positives = 153/285 (53%), Gaps = 13/285 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG---AIFI 57 M +LLA GFCAGV +A+ I E A A + +VHN VV+ R++G + Sbjct: 1 MYVLLARNAGFCAGVRKAVKIAEEA-AEEPDKWFSLGPLVHNDEVVNYFRQKGIEPVDML 59 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+I E P G +I +HG S V +A+ L V DATC LV K+H V R + + Sbjct: 60 ERIGEQPAG--IIIRSHGTSPEVIKQAQELGLEVRDATCVLVKKIHEIVTRLRGEDYDIV 117 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G A HPEVEG +G +V S D+V L V K++ ++QTT + V Sbjct: 118 VFGDARHPEVEGILGWCGQRAS---VVASADEVGYLPVMP--KVALISQTTRDEKEFQKV 172 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 AL + ++ + IC AT +RQEA R L + +++LV+G SSN+ L++ Q Sbjct: 173 AGALSNKCREL--KVFNTICSATRSRQEAARELCRKVDLMLVIGDLKSSNTRTLSKECQN 230 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 G R F I A +I+ EW+ V +G+TAGAS PD +++ V+ R+ Sbjct: 231 TGVRTFQIQKASEIKPEWLDGVSKIGITAGASTPDWIIKEVLDRM 275 >UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=58 Tax=Bacteria RepID=A9KLR6_CLOPH Length = 643 Score = 151 bits (382), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 159/293 (54%), Gaps = 14/293 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA GFC GV RA+ V ++ G +Y ++HN VV L ++G I + Sbjct: 1 MKITLAKTAGFCFGVKRAVDKVYEEIS-NGKEVYTYGPIIHNDEVVKDLEDKGVKVIHSL 59 Query: 61 SEVP--DGAILIFSAHGVSQAVRN------EAKSRDLTVFDATCPLVTKVHMEVARASRR 112 E+ D ++ +HGV ++V + E + ++ + DATCP V K+H V S Sbjct: 60 DELKKLDRGTIVIRSHGVPKSVLDQIKEIEETEGKNFDLVDATCPYVLKIHRIVKEQSEL 119 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G + I+IG HPEV G +G NP + +V + ++ K+ + +E+K+ + QTT + Sbjct: 120 GRQLIVIGDKEHPEVSGIIGWCKNP---VIVVGNAEEAEKIQLSSEQKVCIVAQTTFNYK 176 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 + ++++ + K+ I+ + IC AT RQ L++ +E ++V+G K+SSN+ +L Sbjct: 177 NFQELVEIISKKGYDILVL--NTICNATEERQTEAAMLSKTSEAMIVIGGKHSSNTRKLY 234 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 E++++ + I D+ +K + VG+TAGAS P+ +++ V R+ ++ Sbjct: 235 EISKKECANTYYIQKLIDLDLNQLKSFRSVGITAGASTPNNIIKEVHTRMAEM 287 >UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Bulleidia extructa W1219 RepID=D2MQD5_9FIRM Length = 300 Score = 151 bits (381), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 106/293 (36%), Positives = 159/293 (54%), Gaps = 22/293 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAI + + Y + + +VHN++VVD L + G IE Sbjct: 1 MEIISVQPRGYCHGVVRAIRLAQKTRETYPHTTMTILGMLVHNQHVVDELAKNGIHTIED 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + ++ +G I++F+AHGVS AV +AK + L + DATCP V K H E+ R Sbjct: 61 HHQDRLSLLDKIQEG-IVVFTAHGVSPAVYEKAKEKGLQIVDATCPDVLKTH-ELIR--N 116 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 + I +G HPE EGT+G S ++LV +D+ L + QTTLS+ Sbjct: 117 HPGDVIYLGKKNHPEAEGTIGLSSR----VHLVSCVEDLNTLQSFPLQDPIITNQTTLSL 172 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 D D+I A K++P R +IC AT RQEA+ L + +V+ VVG S+NSN+L Sbjct: 173 LDLQDLITACLKQYPNAKVVR--EICPATRLRQEAILNL--ETDVLYVVGDVRSNNSNQL 228 Query: 232 AELAQRMG-KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 +A++ G +I D+QE + E K + VT+G+S P+ L V++ LQ Sbjct: 229 VNIARKKGISFVKMISSVHDLQEHEIIEKKRIAVTSGSSTPNTLTNQVISFLQ 281 >UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mycoplasma penetrans RepID=ISPH_MYCPE Length = 299 Score = 150 bits (379), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 92/302 (30%), Positives = 157/302 (51%), Gaps = 22/302 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERG------ 53 M+I+ PRGFC GV A + + +Y Y+ +VHN+ ++ L E G Sbjct: 1 MKIIKITPRGFCKGVVDAYATCKKIAKLYPNHEKYLIGWLVHNKEIIKELEELGIQTKDD 60 Query: 54 -----AIFIEQISEVPDG---AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHME 105 + I+ I E+ D I+IFSAHG Q ++A+ + L VFD TC VTK H Sbjct: 61 KNHSRSEIIDSI-EIKDKNNPPIVIFSAHGTDQKTIDKAREKGLVVFDTTCIYVTKTHDL 119 Query: 106 VARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMT 165 + +G + IG HPE T+ + + L+E+ +D+ + ++E+ + Sbjct: 120 IKEKIEQGYQIFYIGVNNHPETISTLS----IDKSIILIETVNDIENIRTESEKPIFVTN 175 Query: 166 QTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNS 225 QTT+S+ + ++ + L+ ++ I K+DIC A +RQ+AV + + +++LVVG S Sbjct: 176 QTTISIYEFEEITETLKSKYKNI--EFKNDICNAAKDRQDAVINMPSEVDLLLVVGDIKS 233 Query: 226 SNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +NS +L E+ + + LI + K+I++EW KC+ +T+G S P L V+ L++ Sbjct: 234 NNSKKLVEIGIKKQIESHLIWNTKNIKDEWFINKKCLAITSGCSTPTWLANYVIIFLEKK 293 Query: 286 GG 287 G Sbjct: 294 LG 295 >UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=bacterium Ellin514 RepID=B9XIS3_9BACT Length = 297 Score = 150 bits (378), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 95/286 (33%), Positives = 144/286 (50%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+ A G C GV AI++ A P+ + ++VHN V+ +LR G F ++I Sbjct: 14 MNIIRAEHMGMCFGVRDAITLATKETA--STPLTILGDLVHNETVLSNLRAHGIKFEQEI 71 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V +++I +AHG S+ NE K+R L V +ATCPLV H VA +R G ++IG Sbjct: 72 EAVTTDSVMI-TAHGASEKSINEIKARGLKVLEATCPLVHFAHRSVAELARDGYHPVIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G +V S D+ L + + QTT ++ ++ Sbjct: 131 KRDHVEVRGLTGDLK----AFDVVLSEADIENL--QERARFGIAAQTTQPIEKVQRLVGI 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +RK+FP D +C T RQ A LA++++VV+VVG +S+N++ L + R Sbjct: 185 VRKKFPNSEVRFVDTVCRPTKQRQFAAVELAQKSDVVVVVGGAHSNNTHELVKTCGRYCP 244 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 R + A D++ EW + VG+TAG S PD + V L+QL Sbjct: 245 RVHHVQFANDLRSEWFENAGIVGITAGTSTPDSTINEVEQALRQLA 290 >UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=8 Tax=Bacteria RepID=D1PP74_9FIRM Length = 639 Score = 149 bits (376), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 94/304 (30%), Positives = 155/304 (50%), Gaps = 16/304 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++ A GFC GVDRA+ + + L G + ++HN VV L +GA+ + + Sbjct: 1 MKVIRAKTAGFCFGVDRAVKLTYDLLG-QGRRVATLGPLIHNPQVVQDLEAKGALTCDGV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VPDG +I +HGV Q V + +R L DATCP V K+H A A ++G ++ G Sbjct: 60 EDVPDGYEVIIRSHGVPQNVYEKISTRGLAYHDATCPFVAKIHKLAAEAGKKGALLLVAG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G +G + P +E ++ ++ +E + + QTT V+ Sbjct: 120 DANHPEVQGIVGHATGPVRVFADLEELQNLLPELLQ-QESIHVVAQTTFRVESWESCKAF 178 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+K K D IC AT RQ+ L+++ + ++V+G +SSN+ +L ++A R Sbjct: 179 LKKECTK--AEIFDTICNATWARQQEAEDLSQKCDRMVVIGGHHSSNTQKLLQVAARH-T 235 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ-----------LGGGE 289 A ++ A ++ W+ + VGVTAGAS P +++ V+ + + L E Sbjct: 236 TAINVETADELDPAWLAGAETVGVTAGASTPSSIIEEVLNSMSEEIRDDMSFEEMLAASE 295 Query: 290 AIPL 293 A PL Sbjct: 296 AKPL 299 >UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5G9_THEAS Length = 280 Score = 149 bits (375), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 92/285 (32%), Positives = 150/285 (52%), Gaps = 5/285 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L+A+P G C GV RAI +E L G +Y +HN V+ L+ +G + +++I Sbjct: 1 MKVLVASPTGLCFGVRRAIEALEATLEERGR-VYSLGSPIHNPQEVERLKAKGLVVVDEI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP G L AHGVS V EA R V D TCP V K S G +++G Sbjct: 60 DQVPPGVTLFIRAHGVSPQVFREALRRCGEVIDGTCPFVRKAQERAMVLSDEGYPVLIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G + + ++V L +K+ ++QTT ++ DV+ A Sbjct: 120 DGEHPEVKGILGFVNGFAAVVPHRGRLEEV--LDGHRFQKVGVLSQTTQKLEVFFDVVKA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L P++ + IC AT RQ AV LA + ++V+G +NS+N+ +L ++A G Sbjct: 178 LVGIVPEV--RVYNTICSATLERQRAVCELASSVQGIVVMGGRNSANTRKLYQIALESGA 235 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +A I+ ++ W+ + +G+ AG S PD L++ ++ RL++L Sbjct: 236 QAVWIEHPDELDYGWLADKGSIGLAAGGSTPDWLIRELIERLEKL 280 >UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridiales RepID=B1I3Y7_DESAP Length = 677 Score = 148 bits (373), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 94/285 (32%), Positives = 146/285 (51%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA GFC GV RAI + + PIY ++HN VV L E+G +E+I Sbjct: 1 MEVRLATKAGFCFGVHRAIDLALKTVRETAPPIYSLGPLIHNPQVVAYLAEQGIEVVEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 VP G LI +HGV + + + TV DATCP V + + G + I++G Sbjct: 61 ERVPRGT-LIIRSHGVEPKLLEKTRELGFTVVDATCPFVKRAQRLACDLNDSGHQVIVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G ++N G +VE D V + ++ + QTT + V++ Sbjct: 120 DRKHPEVRGIVG-WTN--GQAVVVE--DRVEASALPFYPRVGVVAQTTQPHANLEAVVEE 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R +++ D IC A RQ A LA Q +V++VVG +S+N+ +L L + G Sbjct: 175 LKSRMGEVL--VCDTICNAVVERQNAALTLARQVDVMVVVGGIDSANTRKLTGLCRLSGT 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ +Q EW + G+TAGAS PD +++ V R+++L Sbjct: 233 PTYHIETGDQLQSEWFRGCTVAGLTAGASTPDWIIEEVKRRMEEL 277 >UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MRX3_ANATD Length = 663 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 98/286 (34%), Positives = 152/286 (53%), Gaps = 7/286 (2%) Query: 1 MQILLANPRGFCAGVDRAIS-IVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV RA+ ++ A A G I V ++HN YV+D L++ G +E Sbjct: 1 MIIKVAQSAGFCFGVQRAVEGVLAWAKANKGKSIKVYGMLIHNSYVIDKLKDLGVKVVED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I ++ I+ +HGVS E + R V+D TCP V K+H V S G + I++ Sbjct: 61 IEQIGKEDIIFIRSHGVSMEEYAEIEKRADKVYDFTCPYVKKIHEIVMEHSVNGYDIIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G +G N ++V+S + V + + E K + + QTT S++ + Sbjct: 121 GDMNHPEVKGIVGHVGNNR-KCFVVDSIEKVKEAINQIEGKAAVVCQTTFDGKKWSEIRE 179 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L V D IC AT NRQ+ + LA+ +++LVVG K SSN+N+L +L + + Sbjct: 180 FLESHTNYKVF---DTICKATINRQKEAQELAQHVDIMLVVGDKKSSNTNKLYKLLKEI- 235 Query: 240 KRAFLIDDAKDIQE-EWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 K F I+ +D+ + +K +GVTAGAS ++ VV L++ Sbjct: 236 KPTFFIEKVEDLDSIKLDSYIKSIGVTAGASTSPEQIEEVVKHLEE 281 >UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YH70_THEYD Length = 289 Score = 147 bits (372), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 87/287 (30%), Positives = 155/287 (54%), Gaps = 8/287 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I+LA GFC GV RAI I + + ++ ++HN VV+ L++ G +++IS+ Sbjct: 5 IVLAEGAGFCFGVKRAIDIAFDVAQKHKDGVFTLGPIIHNPQVVERLKDLGVYPVDEISQ 64 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 LI AHG+ + NE K D + DATCP V K + + G + ++IG Sbjct: 65 -KTIKTLIIRAHGIPKEKFNELKQLDCEIIDATCPFVKKAQNLAEKLASEGYQVLIIGDR 123 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVK---NEEKLSFMTQTTLSVDDTSDVID 179 HPEV+G +S ++ D+ K + K +K+ + QTT + ++++ Sbjct: 124 EHPEVKGI---FSYAGEKAIVINHADNELKESKKIPILNKKIGIIQQTTQPMSKVKEIMN 180 Query: 180 ALRKRFPKIVGPR-KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + R + +C T+ R EA +A++ +V++VVG KNS+N+ +LA L +++ Sbjct: 181 KIINSLNEFEEIRIFNTLCNFTSRRLEATEKVAKEVDVMIVVGGKNSANTTQLANLCRKI 240 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 G + + I+DA++I ++WV K +GVTAGAS P ++ V+ ++++ Sbjct: 241 GVKTYHIEDAQEIDKKWVNSAKKIGVTAGASTPQWIIDEVIDKIKKF 287 >UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N521_SLAHD Length = 276 Score = 147 bits (371), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 94/285 (32%), Positives = 150/285 (52%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL A G C GV+RA+ +V A + ++HN VV L RG ++ Sbjct: 1 MEILRAKHAGVCYGVERALDMVSAASMDGDEDTFTLGPLIHNPQVVAKLESRGVRAVDGP 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +V D I+I HGV + + KSRDLTV DATCP V K A + ++IG Sbjct: 61 EQV-DHGIVILRTHGVEPHIAADLKSRDLTVIDATCPHVAKAQRSAANLADTCGTVLIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPE+ ++ +Y+ + + DV ++ EE + + QTT S + V++ Sbjct: 120 RAEHPEIR-SVREYAGEKAIVVA-----DVDEVPEHLEEPVGVIVQTTESKEKLQAVVNE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R + K+ IC+AT RQ+A ALA++ + ++V+G KNSSN+ L E+ + Sbjct: 174 LEAR--GVETQVKNTICFATRQRQDAAAALADEVDAMVVIGGKNSSNTTHLYEICRDHCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++ ++ +++ W VGVTAGAS PD +++V++ L+ L Sbjct: 232 RSYFVETKEELDPSWFSATDRVGVTAGASTPDYQIEDVISYLESL 276 >UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=36 Tax=Clostridium RepID=ISPH_CLOPS Length = 282 Score = 147 bits (370), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 87/292 (29%), Positives = 161/292 (55%), Gaps = 21/292 (7%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG--AIFIEQ 59 ++LA GFC GV RA+ +G IY ++HN VV+ L + AI + Sbjct: 4 NVILAKNAGFCFGVKRAVDEAIKYQKEFGKKIYTLGPLIHNNDVVNYLEDNDIFAIELSD 63 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + G +++ +HGV ++V + + L V +ATCP VT + ++V + +G + I++ Sbjct: 64 TNSLNKGDVVLIRSHGVKESVIKDLTDKGLIVKNATCPYVTNIQLKVKKCYEQGYKIIIV 123 Query: 120 GHAGHPEVEGTMGQYSNP----EGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 G HPEV G G ++ G L P K+ ++QTT + + Sbjct: 124 GDENHPEVIGINGWCNDSAIITNGKTELENIP-----------AKVCVVSQTTEKKETWN 172 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 V++ + K +IV + IC AT RQ++V+ L+++A++V V+G KNSSN+ +L E+ Sbjct: 173 KVLNEIVKESKEIVAF--NTICSATDVRQKSVQELSKEADLVFVIGGKNSSNTTKLYEIC 230 Query: 236 QRMGKRAFLIDDAKDIQEEWVKE--VKCVGVTAGASAPDILVQNVVARLQQL 285 ++ +++ I++ K++ E +++ VK +G+TAGAS PD ++ V++++++L Sbjct: 231 KKECPKSYHIENVKELDESLLEDESVKTIGITAGASTPDWIINEVISKIKEL 282 >UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=19 Tax=Fusobacterium RepID=ISPH_FUSNN Length = 827 Score = 145 bits (367), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 157/289 (54%), Gaps = 13/289 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M+I+ A GFC GV AI++ N+L Y+ +VHN+ VV+ + +G + + Sbjct: 1 MEIIRAKHMGFCFGVLEAINVC-NSLVEEKGRKYILGMLVHNKQVVEDMERKGFKLVTED 59 Query: 60 -----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + E+ + I++ AHG S++V + K R + VFDATC V K+ E+ A+ G Sbjct: 60 ELLNDMDELKEDDIVVIRAHGTSKSVHEKLKERKVKVFDATCIFVNKIRQEIEIANENGY 119 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 + +G HPEV+G + + + + ES ++ KL + ++ TQTTL+ Sbjct: 120 SILFMGDKNHPEVKGVISFADD----IQIFESFEEAKKLKIDLDKTYLLSTQTTLNKKKF 175 Query: 175 SDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 ++ ++ + +V D IC AT RQ+AV LA + EV+++VG SSN+ +L E+ Sbjct: 176 EEIKKYFKENYKNVVIF--DKICGATAVRQKAVEDLAVKVEVMIIVGDTKSSNTKKLYEI 233 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 ++++ ++L+++ + + + + VG+TAGAS P+ + N+ +++ Sbjct: 234 SKKLNDNSYLVENEEQLDLSIFRGKEVVGITAGASTPEETIMNIEKKVR 282 >UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Opitutus terrae PB90-1 RepID=ISPH_OPITP Length = 289 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 96/302 (31%), Positives = 161/302 (53%), Gaps = 30/302 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L A GFC GV+RAI I + P+Y ++HNR +++ L E G I Sbjct: 1 MKVLRAKSAGFCWGVERAIEITRDYAHQGRKPVYTDGPLIHNRQMMEKLSEEG------I 54 Query: 61 SEVPD----------------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHM 104 EV D +++ AHG+S RN KS + DATCP V + Sbjct: 55 REVGDYQSRANIAVNPAAPGENPVMVVRAHGISPERRNYLKSLGMDFKDATCPDVGIIAG 114 Query: 105 EVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFM 164 ++ +++G +I+ G HPE G +G Y+ EG Y + S D+ L E++ + Sbjct: 115 KIRLHAKKGYATIIFGDKNHPEAIGLLG-YT--EGRGYCITSKADIDALPAL--ERVCMV 169 Query: 165 TQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ-AEVVLVVGSK 223 +Q+T+ + + +++ + R++F +++ D IC AT +RQ V ALA Q A+ ++V+G Sbjct: 170 SQSTMFMHEFAELSEYARQKFKEVL--VFDTICQATKDRQTDVVALARQGAQAIVVIGGH 227 Query: 224 NSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 +S+N+ +LA LA+ + I+ A ++ E +K+ +GVTAGAS P+ L+ V A+L+ Sbjct: 228 HSANTVKLASLARLQNLPTYHIETAAELSPEEMKKFTVIGVTAGASTPEFLISEVCAKLE 287 Query: 284 QL 285 L Sbjct: 288 AL 289 >UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Dictyoglomus RepID=ISPH_DICT6 Length = 283 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 94/286 (32%), Positives = 161/286 (56%), Gaps = 12/286 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + +A P GFC+GV ++IS+ E L+ G +Y +VHN V++ L ++G +E+ Sbjct: 1 MILYIATPYGFCSGVKKSISLAEKVLSNEGE-VYTLGALVHNPKVIEELSKKGIKILEKN 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V +G LI AHG+ Q ++ V+DATCPLV KV + ++ + ++IG Sbjct: 60 GFV-EGKALIVRAHGLPQRDIEFYRTLGNRVYDATCPLVKKVQILAEYLNKNKYKVVIIG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G + Y++ +G +VE+ DD+ K ++N K+ + QTT S+D+ ++ Sbjct: 119 EKNHPEVIGILS-YTDDQG--IVVENEDDIKK--IENYPKIGIVFQTTQSLDNALQKVNL 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA-ELAQRMG 239 + ++ +I + IC T RQE + L+E ++ LV+G KNS+N+ RL L++++ Sbjct: 174 IMEKGKEI--RIFNTICPETIERQEKAKKLSEMVDLALVLGGKNSANTRRLYITLSKKIP 231 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I++ ++I + W KE VG+ G S P+ V+ VV L+ L Sbjct: 232 --TYHIENIEEIDKSWFKEDNKVGIITGTSTPNDFVEEVVELLKSL 275 >UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D7I4_9ACTN Length = 282 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 94/285 (32%), Positives = 143/285 (50%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A G C GV+RA+ +VE I+ ++HN VV L +G I Sbjct: 1 MHIRIATEAGACYGVNRALDMVEALSHKIHGRIHTLGPLIHNPQVVSKLAAKGVEVIHNA 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV AIL+ + HGV+ +A V DATCP V + H ++ G + ++ G Sbjct: 61 DEVSGKAILLRT-HGVTPEEEKKAYQSHDIVVDATCPFVIRAHRAAETLTKEGYQVLVFG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GH EVEGT+G G VE+P+D+ L++K ++ + QTT S +++ A Sbjct: 120 EKGHAEVEGTLGHAP----GAVCVETPEDIEALSIKR--RVGIVVQTTQSRRRLKEIVAA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +I D IC AT+ RQ A LA+ + ++V+G K S+N+ RLAE+ + Sbjct: 174 LVGKAEEI--RLFDTICEATSLRQNAATDLAKSVDCMIVIGGKISANTTRLAEICRTYCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ A+++ W VG+TAGAS P + V RL L Sbjct: 232 HVYHIETAEELDPAWFSPTSEVGITAGASTPQYQIDEVYKRLMSL 276 >UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VSI0_9FIRM Length = 725 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 95/291 (32%), Positives = 156/291 (53%), Gaps = 13/291 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RA + A A +Y ++VHN V++ L+E+ IE Sbjct: 1 MEIYLADYAGFCGGVKRACKL---AFAAADEGVYCLGDIVHNEVVINDLKEKKVKTIEN- 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++V + ++I S HGV + + + + + D CP V K++ V + ++G I++G Sbjct: 57 TQVYNSKVIIRS-HGVPKEDLEKLRYNNNEIIDCVCPKVKKIYNIVEKYYKKGYNIIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G + Y N E ++ + ++ K+ V K + Q+T S + D + Sbjct: 116 DENHPEVKG-INSYCNNEAIIF---NKEEDLKVPVG---KTIVVAQST-SNEKVFDYLTN 167 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K K + IC AT NRQ ++R LA+ + V+V+G K SSN+ +LAE+A+ K Sbjct: 168 LIKNISKSEILVYNTICDATFNRQNSIRKLAKIVDAVIVLGGKKSSNTKKLAEVAKESCK 227 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 FLI KDI +K+ +G+TAGAS PD +++ V+ ++ GE + Sbjct: 228 NVFLIQSIKDIDINILKKFNKIGITAGASTPDKVIKEAVSSMENFDKGEMM 278 >UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfitobacterium hafniense RepID=B8G2Q3_DESHD Length = 661 Score = 144 bits (362), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 88/285 (30%), Positives = 151/285 (52%), Gaps = 11/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+ A GFC GV RA+ + E + + ++HN+ VV+ + ++G + ++ Sbjct: 1 MKIIRAEKAGFCFGVKRALDMAERT--VQSSSTASLGPLIHNQQVVEKMEKQGVRVVGEV 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G LI +HGV + EA+ + V DATCP V K A +S+ G + +++G Sbjct: 59 KETQAGDTLIIRSHGVPPDIYEEARRCQVKVVDATCPFVQKAQRLAAESSQSG-QVVVVG 117 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G G +E+ ++ +L E+LS + QTT + ++D Sbjct: 118 DRQHPEVQGILGWAG---GNAIAIETLEEARELPFY--EQLSVLAQTTQPAANFHGIVDE 172 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + + IC AT RQ R LA + +V++VVG KNS+N+ +LA + Sbjct: 173 LKTHTHAL--KVHNTICNATEERQTVARELAGKVDVMIVVGGKNSANTRKLAGICSER-T 229 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + +LI+ A ++++ W V VG+TAGAS PD +++ V ++ + Sbjct: 230 QTYLIETADELEDNWFTGVVTVGLTAGASTPDWIIEEVYRKMSTM 274 >UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RIU7_MOOTA Length = 736 Score = 143 bits (361), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 94/282 (33%), Positives = 144/282 (51%), Gaps = 12/282 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A+ GFC GV RA+ A P+ ++HNR VVD L G + + Sbjct: 1 MEVIVADYAGFCFGVKRAVEKAREAPK----PVASLGMLIHNRQVVDQLAREGVRPVASL 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G ILI S HG + A+ + L + DATCP V + + + G + I++G Sbjct: 57 DEVNCGRILIRS-HGTTPETLVRARDKGLEIIDATCPYVKRAQHLAQKMAAEGYQVIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G +G ++ P G +V PD + + + + QTT +V A Sbjct: 116 DAAHPEVQGMLG-WAGP--GAVVV--PDKKAAAALPFHPRRAVLAQTTQPESRLEEVAAA 170 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR +V + +C AT RQEA LA Q +V++VVG K S+N+ LAEL + G Sbjct: 171 LRSNTDTLV--VHNTVCQATHQRQEAAVRLARQVDVMVVVGGKESANTRHLAELCRATGT 228 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 + ++ A ++ +W + VGVT GAS P +++ VV L Sbjct: 229 PTYHVERAGELCRQWFINTRRVGVTGGASTPAWIIEEVVGML 270 >UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E01-6750 RepID=UPI000190F3D8 Length = 83 Score = 143 bits (360), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 67/83 (80%), Positives = 76/83 (91%) Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 +AQRMG+ AFLIDDA DIQE WVK+ CVGVTAGASAPDILVQNV+ARL++ GGGEA+ L Sbjct: 1 MAQRMGRTAFLIDDAADIQEAWVKDAACVGVTAGASAPDILVQNVIARLREFGGGEAVTL 60 Query: 294 EGREENIVFEVPKELRVDIREVD 316 EGREENIVFEVPKELRVD+REV+ Sbjct: 61 EGREENIVFEVPKELRVDVREVE 83 >UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphate reductase protein n=1 Tax=Spiroplasma citri RepID=Q14P56_SPICI Length = 293 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 92/298 (30%), Positives = 154/298 (51%), Gaps = 18/298 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI-- 57 M+++ PRG+C GV ++I + A Y G IY+ +VHN++V+D + G I + Sbjct: 1 MKVVKVTPRGYCLGVVKSIKWAKEAAIKYAGRQIYMLGYLVHNKHVIDEIVNLGVIPVND 60 Query: 58 ------EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVAR-AS 110 E I +PD A++I SAHG +++ A +++T+ D C VT + + Sbjct: 61 FKLNRLELIQTLPDNAVVILSAHGSDDRIKDVAVQKNITLVDTECEWVTVTKNLIKEYLA 120 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTT 168 + + I IG HPE + + LV + +V + + +K+ QTT Sbjct: 121 KPDYQIIFIGKHFHPETNAMLAL----SPTINLVTTEQEVVSILPNLDPTKKILITNQTT 176 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRAL-AEQAEVVLVVGSKNSSN 227 LS D +++ L+ P + K+D+C AT RQ AV +L +++LVVG + SSN Sbjct: 177 LSKIDIEAIVEKLKTLVPNEII-FKNDLCNATLERQNAVLSLDPTTIDLLLVVGDERSSN 235 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + +L + +++G ++ I+D DIQ W+ CV VTAGAS P I+ V+ L+Q+ Sbjct: 236 TLKLVAMGEQIGIESYRINDKSDIQPTWLANKTCVAVTAGASTPSIIQLEVIRYLEQI 293 >UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LUA5_SYNAS Length = 577 Score = 142 bits (357), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 95/288 (32%), Positives = 158/288 (54%), Gaps = 11/288 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGA-PIYVRHEVVHNRYVVDSLRERGAIFI-- 57 M + LA GFC GV RA+ V + G+ IY ++HN V+ LRERG I I Sbjct: 1 MSVFLAKTAGFCMGVKRAVDTVLDIARHKGSEKIYTYGPLIHNPQTVEFLRERGIIPIKD 60 Query: 58 -EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 E +S A ++ AHG+S + R + +++ L + DATCP VT V + + + + Sbjct: 61 IEALSASDQNAAIVIRAHGISPSERKKIRNKGLRIIDATCPKVTHVQAIIRQHAAKDYNI 120 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 ++IG HPEV G +G ++ S +V +L + EK+ + QTT +V++ + Sbjct: 121 LIIGDGDHPEVNGLLGHAGG---HGRVIGSLQNVEELPIM--EKVCVVAQTTQNVEEYAA 175 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 ++ +R RFP+ V + IC +T RQ VR LA + E +++VG +NS+N+ RLA L+ Sbjct: 176 IVRRIRDRFPETV--VFNTICDSTEQRQAEVRELAARMEAMVIVGGRNSANTRRLAALSS 233 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + G F I+ A ++ + + +G++AGAS P+ ++ VV R+ + Sbjct: 234 QQGTPTFHIETADELNDAKLAPYDRIGLSAGASTPNWIIDRVVDRIAE 281 >UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D54C36 Length = 166 Score = 141 bits (356), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 73/162 (45%), Positives = 112/162 (69%), Gaps = 1/162 (0%) Query: 149 DVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVR 208 DV L V++ + L+++TQTTLS+DDT V+ AL+K+FP I GP K+DICYATTNRQ AV+ Sbjct: 2 DVQNLEVRDTQNLAYVTQTTLSIDDTFSVVQALQKKFPAIQGPHKEDICYATTNRQLAVK 61 Query: 209 ALAEQAEVVLVVGSKNSSNSNRLAELAQRMG-KRAFLIDDAKDIQEEWVKEVKCVGVTAG 267 +A + + +LVVG+ NSSNS RL E+ +R G K + L+ A +I ++ ++ +G+TAG Sbjct: 62 EIANKIDALLVVGAPNSSNSKRLVEVGKRAGCKYSQLVQRASEIDFRALEGIENLGITAG 121 Query: 268 ASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 ASAP++L+ V+ ++ + +E EN+ F+VP+ LR Sbjct: 122 ASAPEVLIDEVINSFRETHLVDVEIVETAVENVNFKVPRVLR 163 >UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Anaeromyxobacter RepID=ISPH_ANADF Length = 283 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 88/285 (30%), Positives = 143/285 (50%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV R + V P+ ++HN V RE+G ++ + Sbjct: 1 MEVKIAKTAGFCWGVRRTVDKVMEVADHASGPVVTLGPIIHNPQAVARFREKGVGTVDAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV DG ++ HG + + A+ R L V D TCP V R S G +++G Sbjct: 61 GEVGDGTTVVVRTHGAVKEELDRAEGRGLEVVDGTCPYVKYPQAIAQRLSAEGYHVVIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A H E++G + YS EG +V+ + ++ K K++ + QTT D V+ A Sbjct: 121 DANHAEIKGVI-SYS--EGPCTVVKPGGPIPEIPAK---KVAVIAQTTCIGADFEAVVGA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R ++ + IC T RQ R+LA + + V+VVG KNS+N+ LAE+ + + Sbjct: 175 LALRHKEVRA--VNTICNDTEERQADARSLAREVDAVVVVGGKNSANTRHLAEICREIQP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R + ++ +++ EW + VG++AGAS PD +V+ V L+ L Sbjct: 233 RTWHVETEAELRPEWFTGCQVVGLSAGASTPDWVVEGVAGWLRGL 277 >UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LQM8_DESBD Length = 286 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 154/286 (53%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY---GAPIYVRHEVVHNRYVVDSLRERGAIFI 57 M++++A GFC GVD A+ ++NA++I IY ++HN V+ + G + Sbjct: 1 MELIIAETAGFCMGVDMALHKLDNAVSIPPQDAQHIYTLGPIIHNPQVLARYKGLGVLQT 60 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + + G +++ AHG+ + ++ + +++TV DATCP V K + + R + + + + Sbjct: 61 DGTKPLQTGDVVVIRAHGIPRHIQTSLEGQNITVVDATCPKVKKAQILIQRQADQNKHLL 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 L G HPEV+G + Y+ P+ ++ ES +++ V + QTT + + Sbjct: 121 LFGERDHPEVQGLVS-YA-PKHTIF--ESLEELQAYEVDPAQTYFLAAQTTQDRESFDTI 176 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + LR + D IC AT +RQE VR L+ + + +++VG KNS N+ RLA++AQ Sbjct: 177 REYLRANVDAAMT-ILDTICMATKDRQEEVRELSRKVQAIVIVGGKNSGNTRRLAQIAQE 235 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 G A ++ A+++ E + +G+TAGAS P ++QNV L+ Sbjct: 236 SGIFAIHVETAEELPLEELAAFTRIGLTAGASTPPWIIQNVAQTLR 281 >UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AGH3_SEBTE Length = 291 Score = 140 bits (353), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 86/293 (29%), Positives = 157/293 (53%), Gaps = 16/293 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 ++I+ A GFC GV A+ V + + IYV +VHN +V++ L ++G IF+ + Sbjct: 5 IEIIRAEHMGFCFGVREAVDEVHRYVDMNRGQIYVLGMLVHNEFVIEKLLKKGVIFVSEE 64 Query: 60 -----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + + G I+I AHG +Q V+ + + + D C V +V +RG Sbjct: 65 DVLNNNTPLKSGDIVIIRAHGTTQNVQKKLLEIGVKLIDMACIYVKSARDQVVIWEQRGY 124 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 +S+ IG HPEV+G P + S D++ + + EK F+ QTT + Sbjct: 125 KSVFIGDKDHPEVKGITSYGIKP----LIFGSLDELKQAELDINEKWVFLFQTTYNRFIF 180 Query: 175 SDVIDALRKRF--PKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 ++ D + RF K+V IC AT RQ A+ LA++ + V ++GS+ SSN+ +L Sbjct: 181 QEINDYIINRFINYKVVKT----ICGATHQRQSAIEKLAQEVDAVFIIGSEQSSNTKKLY 236 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++++ + ++++LI++ DI++ + V+ +GV+AGAS P+ L+ + ++++L Sbjct: 237 QISKNLNEKSYLIENNDDIKKHMLDGVRKLGVSAGASTPEELIAIIENKIKEL 289 >UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C8WAL7_ATOPD Length = 284 Score = 140 bits (353), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 86/289 (29%), Positives = 158/289 (54%), Gaps = 11/289 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I +A+ G C GV+RA+ +V+ A+ AP+ ++HN VV SL+++G ++ SE Sbjct: 4 IKIADEAGACYGVERALQMVQQAVKDAHAPVRTLGPLIHNPRVVTSLKDQGVEVVDFASE 63 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 G+ L+ HGV+ AK + V DATCP V K H +++G ++G + Sbjct: 64 AA-GSALLLRTHGVTPQEEQIAKDGCVDVLDATCPFVKKAHRAAELLAKQGYAVYVVGES 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT--VKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEVE T+ G ++S ++V ++ +K+ + QTT+S S+V++A Sbjct: 123 GHPEVEATLAHVP----GSLAIDSVEEVAAQADAMRVAKKVGLVVQTTMSAAKLSEVVNA 178 Query: 181 LRKRFPKIVGPR-KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + P + R + IC AT Q++ LA++++V++++G + S+N+ RLAE+++ Sbjct: 179 V---LPLVDELRVMNTICEATAGHQDSCMRLAKESDVMIIIGGRISANTTRLAEISKLYC 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 + I+ ++Q W + + +G+TAGAS P+ + V ++++ G Sbjct: 236 PATYHIEGTDELQASWFEGAEHIGITAGASTPEAHINAVKLAIEEIVGA 284 >UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPH_PETMO Length = 284 Score = 140 bits (352), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 86/289 (29%), Positives = 158/289 (54%), Gaps = 16/289 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC+GV + + V+N+L + IY+ E+VHNR V++ L GAI I + Sbjct: 1 MEINVAKRTGFCSGVQKTYNEVKNSL-VDKNKIYIYGELVHNRKVIEELNSAGAITITGM 59 Query: 61 SEVPDGAI---LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 ++PD +I LI AHG+S+A ++ K R V D TCP+VT + V + + G + Sbjct: 60 DDIPDDSIDETLIIRAHGISKAEKDLLKKRFSKVIDMTCPIVTNLVKYVEKKQKDGFFVV 119 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G HPE+ G G E + + SP + ++K+ ++QTT+ ++ + Sbjct: 120 VYGKPDHPEILGLKGNVD--ESKLLITLSPVTIP------QKKVLIVSQTTMGEEEYKNF 171 Query: 178 IDALR--KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 I ++ F +++ +D IC T R++ L++++ ++LV+G KNSSN+ +L ++ Sbjct: 172 ITSILTINSFTEVL--IRDTICSETILREKETLELSQKSTLMLVLGGKNSSNTQKLYRIS 229 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 ++ KR + I+ ++++E + +G+ G+S P + V+ L Q Sbjct: 230 KKYCKRTYHIESGEELKEITISPQDKIGIVTGSSTPTSELNKVLEYLSQ 278 >UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8 Tax=Clostridiales Family XI. Incertae Sedis RepID=C7RHT6_ANAPD Length = 686 Score = 139 bits (351), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 154/287 (53%), Gaps = 12/287 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++AN GFC GV R++ + E A+ G Y ++HN +V+ L G +++ Sbjct: 1 MEIIIANYSGFCGGVRRSVELAEEAIKNEGER-YCVGPLIHNPQLVEKLENEGLEVVDKK 59 Query: 61 S--EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 ++ D +LI AHG S + + V DATCP++ ++ ++ G + ++ Sbjct: 60 EALKIKDSTVLI-RAHGESADFKERLLANGNEVVDATCPVLNNIYKKIIEKENDGYQVVI 118 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G HPE+ + S G+ + D+ +K KL ++QTT +D D+ Sbjct: 119 VGDKTHPEI---IAMESFLNNGIIV---SDETEAKNIKCNNKLYVVSQTTNRLDYFYDIA 172 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + L++ +V ++ IC AT NRQEA ++LA++ + ++V G NSSN+N+L ++A Sbjct: 173 NKLKENNDSVV--IENTICKATENRQEAAKSLAKEVDCMIVAGGFNSSNTNKLYQVANLY 230 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 K F I+ KD+ + + + K VG+ AGAS PD +++ VV+ + + Sbjct: 231 CKNVFRIETVKDLPLQKLSKFKKVGIIAGASTPDEIIEEVVSSMDEF 277 >UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=delta proteobacterium MLMS-1 RepID=Q1NXJ4_9DELT Length = 361 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 94/295 (31%), Positives = 149/295 (50%), Gaps = 28/295 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA+ + PI ++HN V+ L ++G +E++ Sbjct: 85 MKVILAKHAGFCMGVRRAVETTLELVEKSRGPIATFGPLIHNPQVLTMLGQKGVEVLEEV 144 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G ++I AHGV A + + V DATCP V KV + + R+G ++++G Sbjct: 145 PEQSQGTVVI-RAHGVPPARKQSLEESGAVVEDATCPRVVKVQAIIDKYRRQGYTTVIVG 203 Query: 121 HAGHPEVEGTMGQYSNPEGGMYL----------VESPDDVWKLTVKNEEKLSFMTQTTLS 170 H EVEG +G E G+ + ++ P V T ++EE +T LS Sbjct: 204 DRDHAEVEGLVGHAG--EVGLVISSMEELDGLELKPPYIVVSQTTQDEEMFQLITAGVLS 261 Query: 171 VDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 RFP G + IC +T RQ+ VR + Q + ++VVG +NS+N+ R Sbjct: 262 -------------RFPG--GKVFNTICDSTHKRQDEVREMCRQVDALVVVGGRNSANTKR 306 Query: 231 LAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 LAE+A+ + FL++ ++Q E ++ + VGVTAGAS P ++ VV L+ L Sbjct: 307 LAEIARGLACPVFLVETEAELQFEQMRRYQSVGVTAGASTPVWSIRQVVDALEAL 361 >UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M529_9BACT Length = 289 Score = 139 bits (349), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 84/279 (30%), Positives = 141/279 (50%), Gaps = 8/279 (2%) Query: 6 ANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPD 65 A P G C GV RAI+ +E AL+ G +Y +HN + L ++G + +VP Sbjct: 8 AEPTGLCFGVKRAIAQMEKALSSDG-ELYCVGSPIHNPQEIARLAQKGLRVVASPQDVPS 66 Query: 66 GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHP 125 G+ + AHG++ +RN K R++ + D TCP V G ++ G A HP Sbjct: 67 GSTVFIRAHGIAPDLRNALKQRNVRIIDGTCPFVRVAQARAKALEDEGYSVVVAGDASHP 126 Query: 126 EVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRF 185 EV +G N G +V + D+ L E++ F++QTTL D + ++ A + Sbjct: 127 EVISIVGGLQN---GAKVVSNSTDLQDLA--KIERIGFVSQTTLPEDLFASIVSAAVRIS 181 Query: 186 PKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLI 245 P + + IC AT RQ AV L ++ + ++V+G ++S+N+ +L +A+ G I Sbjct: 182 PDV--KAHNTICRATFERQRAVAELVKRTDGIVVIGGRDSANTAKLFHIAKSCGADVLWI 239 Query: 246 DDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 ++A ++ +W VG+ AGAS PD L++ + +Q Sbjct: 240 EEAGELDGKWFTGKTHVGIAAGASTPDWLIEEFIQAARQ 278 >UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYQ1_UNCTG Length = 300 Score = 138 bits (348), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 157/292 (53%), Gaps = 16/292 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +++ +A GFC GV RAI + E A +Y V+HN V L ++G ++ Sbjct: 7 LRVKIAENAGFCFGVRRAIDLTEKT-AGKERKVYTLGPVIHNPQEVKRLEKKGIKTLKDP 65 Query: 61 SEVPDGAILIFSAHGVSQAVRNE-AKSRDLTVFDATCPLVTKVHMEVARAS----RRGEE 115 +V G+I I HG+ + + +++++ V DA CP V + + R S + + Sbjct: 66 KKVKSGSI-ILRTHGIPCNLHKKLEENKNINVIDAACPFVKRAQNTIKRLSTDIKSKDKT 124 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 I++G HPEV + S G +VE+ + K + + L+ ++QTT + ++ + Sbjct: 125 IIVVGEKIHPEV---IALVSYGSGKCIIVENIKEAQKFRGRGD--LNIVSQTTQTPENFN 179 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 +I L+KR+ V + IC AT +RQ+A LA+ ++++V+G KNS N+ RLA++ Sbjct: 180 SIIKVLKKRYKTKV---YNTICKATLDRQKAAEKLAKNVDLMIVIGGKNSGNTTRLAQIC 236 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K + I+ A I+E+W K + VG+TAGAS PD +++ + R++++G Sbjct: 237 SEKTK-TYHIETACSIKEKWFKNINSVGLTAGASTPDWIIKEIEMRIKEVGA 287 >UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/ribosomal protein S1 n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMR5_9FIRM Length = 658 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 90/286 (31%), Positives = 157/286 (54%), Gaps = 11/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I A GFC GV +A+ I ENA A+ G ++HN VV L +G + Sbjct: 17 MKIYKARVMGFCYGVRKAMEIAENA-AVSGQKTVTLGPIIHNPQVVARLAGKGISPVMST 75 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA-SRRGEESILI 119 E+ D ++I S HG+ + N K + + DATCP V K + E+A+ + G++ +L+ Sbjct: 76 DEITDETVIIRS-HGIGPSCYNNLKRKKSVLLDATCPFV-KRNQEIAKGLAAEGKKIVLV 133 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPE+ ++ +++ Y+VE+ +DV L + +++ + QTT S+ +I Sbjct: 134 GEKKHPEML-SVAEWAGE--APYIVETMEDVEALP--DLDEVHIVIQTTFSLSLADRLIT 188 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 A++++ + + IC AT++RQ A LA +V++V+G +NS+N+ RL E+ Q G Sbjct: 189 AIKRKAGSVSVHKT--ICNATSDRQTAAGELARNVDVMIVIGGRNSANTGRLVEVCQAEG 246 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 I+ A ++++EW VG+TAGAS PD +++ V ++ + Sbjct: 247 AVTHHIETAAELKKEWFHSQCKVGITAGASTPDWIIEEVFFIMEDM 292 >UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMG2_9BACT Length = 275 Score = 137 bits (346), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 18/283 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A P G C GV RAI +E AL G ++ +HN V L ++G + +E Sbjct: 1 MKVVVAEPTGLCFGVKRAIRTMEEALEEKGR-VFCIGSPIHNPQEVQRLVDKGLVVVEDD 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P + AHG+S V + + + D TCP V K R SR G +++G Sbjct: 60 DRIPPDEPVFVRAHGISPDVHQRLQDKGARIIDGTCPFVRKAQEMAGRLSREGYYLVVLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE++G +G P YLV ++ K + + + T+ Sbjct: 120 DENHPEIKGILGYVEGP----YLV--------VSGKKDLRAIDKIDKIGIISQTTQQEST 167 Query: 181 LRKRFPKIVGPRK-----DDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 L++ + VG + + IC AT RQEAVR LA + + ++++G NS+N+ +L +A Sbjct: 168 LKELVSEAVGSAREIKVSNTICRATVERQEAVRRLAYKVDGIVIIGGHNSANTGKLFRIA 227 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 Q G A ++ A + W+ +G+ AGAS PD L++ + Sbjct: 228 QESGTPALWVEQADQLDGRWLSGKGTIGIAAGASTPDWLIKQL 270 >UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZT29_DESOH Length = 577 Score = 137 bits (345), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 93/283 (32%), Positives = 147/283 (51%), Gaps = 8/283 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV RA+ +V +A Y PIY ++HN V+ L E+ +E I Sbjct: 1 MKVSIAKTSGFCMGVRRAVDMVLDASNRYTEPIYTFGPLIHNPQVLRLLAEKKISVMETI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G +LI AHGV R + ++ TV DATCP V KV ++R + G I+IG Sbjct: 61 PEQGNGIVLI-RAHGVPPRTREKLEAAGFTVIDATCPRVVKVQTIISRNAAEGCAVIIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G Y+ G +V + K + EK + QTT S +V Sbjct: 120 DKDHPEVVGLLG-YAGDRG---VVADSLEALK-ALPAFEKAIIVAQTTQSTRLFDEVGAW 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 P + IC +T NRQ ALA Q + ++VVG NS N+ RLA+++++ G Sbjct: 175 AAAHHPHY--QVFNTICPSTKNRQAETEALARQTDAMVVVGGYNSGNTQRLAQVSKKSGH 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 F ++ ++++ + + +G+TAGAS P+ +++ + L+ Sbjct: 233 PVFHVETSEELDTNALAKSDHIGITAGASTPNWIIKKIYRELE 275 >UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C7MNA7_CRYCD Length = 284 Score = 137 bits (345), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 93/285 (32%), Positives = 145/285 (50%), Gaps = 7/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A+ G C GV RA+++ + A A G + ++HN VV L G + + Sbjct: 1 MEIIIASRAGACYGVQRALNLAQKA-AQSGGDVQTLGSLIHNPQVVAELAASGVEAVSKP 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ +I S HGV+ VR + + DATCP V + + G I++G Sbjct: 60 EELTASRAIIRS-HGVTPQVREGIEQAGADIIDATCPHVLRAQQAARDLALEGRLVIVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEVEG G + + +PDDV + + + + QTT + +ID Sbjct: 119 EESHPEVEGLRAWAEQAGGQVVVAATPDDVPS---QIDGSVGIVVQTTQRREKLDAIIDV 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R I +D IC AT+ RQEA LA Q +V++V+G NSSN+ RL E+ + Sbjct: 176 LKSR--GIEAEIRDTICSATSTRQEAAAELASQVDVMVVIGGHNSSNTTRLFEICRARSP 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +AF I+ ++Q K + VGVTAGAS P+ +++V+ RL+ Sbjct: 234 QAFHIESPDELQAIDFKGAQRVGVTAGASTPEDQIESVIERLRSF 278 >UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q304_9BACT Length = 584 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 155/285 (54%), Gaps = 10/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 +++ +A GFC GV RA+ I+ +A GA +Y ++HN V++ L +R + Sbjct: 5 LKVFVAKTAGFCMGVRRAMDILLDAANEKNIGAKVYTDGPLIHNPQVLEYLEKRDLHIVN 64 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 ++++ + ++I AHGV+ + R E +S+ V DATCP V +V + + + +G +I+ Sbjct: 65 DVTDLSNSTVVI-RAHGVTPSRRAEIESKGAKVCDATCPHVMRVQSIIKKYAAQGYSTII 123 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G GH EV G +G EG ++VE+ +++ L +K+ + QTT I Sbjct: 124 VGDNGHAEVVGLLGY---AEGRGHVVENMENIELL--PPMDKVCIVAQTTQDRHLFKRAI 178 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 D +++R+P + IC +T RQ+ V L + + ++VVG + S+N+ RL + + Sbjct: 179 DEIKRRYPN--SESFETICSSTYKRQDEVVNLCKSVDAMIVVGGRGSANTTRLVTICESQ 236 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 G F ++ +I +K +GVTAGAS P+ +++ VV +++ Sbjct: 237 GTPTFHVETDSEIDLNKLKVFNTIGVTAGASTPNWMIKRVVDKVR 281 >UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GLE4_9DELT Length = 297 Score = 134 bits (337), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 149/286 (52%), Gaps = 7/286 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFIEQI 60 Q+LLA GFC GV A+ ++ AL + I+ ++HN V++ +G I+ Sbjct: 4 QVLLAESAGFCMGVSLALGKLDKALENQTSQRIFTYGPIIHNPQVLEYYHGKGVKIIDNW 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G +++ AHGV V + + +++ + DATCP V K + + + S + ++ G Sbjct: 64 DEPRPGDMVLIRAHGVPLQVEEKLREKNIDILDATCPKVKKAQLLIYKNSAVSDRLLIYG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G + Y+ E +L E+ + K+ + +++ ++QTT + + Sbjct: 124 ELDHPEVKGLLS-YAQCEA--FLFENMQEFKKIALAPKDRYCLVSQTTQDRQEFLSIASE 180 Query: 181 LR-KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+ + +I+ D IC AT +RQ +A Q E + VVG +NS N+ RL ++A++ Sbjct: 181 LKHSQGNEII--TLDTICDATKDRQNETIKIAGQVECMFVVGGRNSGNTRRLYQVARKYC 238 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R I+ ++I E VK VG+TAGAS P+ +Q++ L ++ Sbjct: 239 PRCLHIETKEEIDPEMVKGCSKVGLTAGASTPNSTIQSIYQYLHRI 284 >UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=D1CF50_THET1 Length = 293 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 92/293 (31%), Positives = 141/293 (48%), Gaps = 12/293 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ+ LA GFC GV + + + + + + +VHN VV L+ RG + Sbjct: 1 MQVKLARELGFCFGVKKTLKLFDE-MGSDSRGVKTLGTLVHNPQVVSELKARGVGVAYSV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV D L +AHG EA+ + L + D TCPLVTKV + G + ++ G Sbjct: 60 DEV-DSGTLTITAHGAGPDAYAEAQRKGLRLLDTTCPLVTKVQKIAESLHKDGYQVVVYG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNE------EKLSFMTQTTLSVDDT 174 H EV G +G N + ++ + V +L +KL+ ++QTT + Sbjct: 119 DPNHQEVRGIVGWTENT--ALVSTDAKELVPRLKALTSSKKRVPKKLAVVSQTTQPAERF 176 Query: 175 SDVIDALRKRFPKIVGPRK--DDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 I L P + IC T +RQ AV LA + +V++VVG ++S+N+ LA Sbjct: 177 KSFIAELVSLLPDDFNEFHVHNTICQPTLDRQSAVVELANEVDVMVVVGGRDSANTKHLA 236 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ELA G + I+ ++I W K K VGVTAGAS PD +++ VV ++ + Sbjct: 237 ELASEEGVPTYHIEWPEEIDPNWFKGAKVVGVTAGASTPDAVIEKVVKTIEAI 289 >UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B0MQU3_9FIRM Length = 658 Score = 132 bits (333), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 90/286 (31%), Positives = 143/286 (50%), Gaps = 17/286 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I A GFC GV RA+ I E G+ Y E++HN + L++ G I+ Sbjct: 5 NIETAKSAGFCFGVKRAVEIAEKTAEENGS-CYTLGELIHNGSEIARLQKLGVYPIDSPD 63 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 ++P G LI +HGV+++V + + ++ DATCP V K+H V+++ I+ G Sbjct: 64 DLPQGRTLIIRSHGVAKSVTDYIHDKGISCIDATCPFVAKIHNIVSKSEC---PVIIAGD 120 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT----VKNEEKLSFMTQTTLSVDDTSDV 177 HPEV G +G NP+ + +V D++ K+ + L + QTT + Sbjct: 121 PDHPEVIGIVGHCRNPD-EVSVVRDSDELEKMAELQKFPRQNALIMVAQTTFNSSKWQSC 179 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I +K + I D IC AT RQ+ LA ++ +++ VG KNSSN+ +LA+++Q+ Sbjct: 180 IQVAKKHYTNIT--IFDTICSATAERQKETEELARRSALMVTVGGKNSSNTAKLAQISQK 237 Query: 238 MGKRAFLIDDAKDIQEEWVKEV-----KCVGVTAGASAPDILVQNV 278 F D DI + V E+ VG+TAGAS P +++ V Sbjct: 238 HCPVIFT-QDGSDIDKAAVSELLPLQGGTVGITAGASTPAYIIKEV 282 >UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1C7U3_9FIRM Length = 666 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 80/284 (28%), Positives = 150/284 (52%), Gaps = 9/284 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I A G+C GV++A++ A +Y ++HN +V + L+E+G I+ + Sbjct: 1 MNIRKAKSAGYCFGVNKAVNTAYEASENSNEKVYTLGPLIHNVHVTNELKEKGVSIIDNL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ +G ++I S HGV + + + K ++L + DATCP V + +V + +G I++G Sbjct: 61 DDIDEGTVIIRS-HGVGKEIYEKIKKKNLKLIDATCPYVKSIQNKVEKYHNKGYTIIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 + HPEV+G G N ++ E + K +E + + QTT+ D+ + Sbjct: 120 DSDHPEVKGVNGWCENKAKVIFTKEEAKN-----FKTDENVCVVAQTTIIEALFDDITNI 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++ +V + IC AT+ RQE +A + E ++VVG +SSN+ +L E+++ Sbjct: 175 IKDNCANVVIF--NTICNATSVRQEEASLIASEVEAMVVVGDTHSSNTKKLVEISKSKCD 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 F ++ A D+ ++ +K+ +G+TAGAS P L++ V+ + Sbjct: 233 NVFFVETASDL-DDAIKKYNNIGLTAGASTPTQLIEEVINTMDN 275 >UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBE4_ELUMP Length = 564 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 86/277 (31%), Positives = 146/277 (52%), Gaps = 8/277 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + +A GFC GV +AI V + PI+ ++HN V+ +L E+G I SE Sbjct: 8 VTIAKSAGFCPGVKKAIDKVLELESSGKKPIFTLGPLIHNNQVIATLEEKGITSIGHPSE 67 Query: 63 VPDG-AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 V +L+ AHG++ + E +S V DATCPLV VH +++ + G ++++G Sbjct: 68 VEGKEGVLVIRAHGITPEFQREVESCGKEVIDATCPLVKHVHNNISKYAGEGYTTVIVGD 127 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EV G +G Y+ G Y+V +V L + + +K++ + QTT + + + Sbjct: 128 AGHAEVIGLLG-YTQGRG--YVVADESEV--LALPDFDKVNIVAQTTQKEAAFYKLAELI 182 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +++ + V + IC T RQ A+ A+ V+VVG KNS+N+ RLA+L + + Sbjct: 183 KQKAKEAV--VSNTICEPTKQRQSETIEYAKNADFVIVVGGKNSANTARLAKLCGELAPK 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 ++ D++ +K K + +TAGAS P+ L+ + Sbjct: 241 VLHVETEADLEGHDLKTPKKIFITAGASTPNWLIDRI 277 >UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Thermomicrobia (class) RepID=B9L0U3_THERP Length = 327 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 94/295 (31%), Positives = 142/295 (48%), Gaps = 13/295 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I++A GFC GV RA+ IV NA P+ +++HN VV+ L G + + Sbjct: 16 EIVVAEVLGFCWGVRRALEIVRNA--ARERPVAALGDIIHNPIVVEQLTREGVLPVTDPV 73 Query: 62 EVPDGAI--LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 E + + +AHG EA DL V D TCPLVTKV + + +G ++ Sbjct: 74 EAKRHGLDRVAITAHGAPPTRYQEASVYDLEVIDTTCPLVTKVQRLAQKLALQGYFLVVY 133 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK------LTVKNEEKLSFMTQTTLSVDD 173 G A HPEV G +G ++ E D W K++ + QTT D+ Sbjct: 134 GDAQHPEVRGVLG-WAGTERACAAKSFDDLPWDGPRGTGAMQPPPRKVALIAQTTKRTDE 192 Query: 174 TSDVIDALRKRFPKIVGPRK--DDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 + AL G + + IC T RQEA+ LA ++VLV+G + SSNS RL Sbjct: 193 FTAFAQALAAWVLPHGGELRVVNTICQPTWERQEALARLARTVDLVLVIGGRKSSNSARL 252 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 E+++ +G + L++ + V+ VG+TAGAS PD ++ V+ L +LG Sbjct: 253 VEVSRSLGTPSVLVERPDQLDPALFAPVRRVGITAGASTPDEVILAVIEELVRLG 307 >UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=ISPH_THENN Length = 279 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 98/291 (33%), Positives = 153/291 (52%), Gaps = 26/291 (8%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VEN L G + E+VHNR V++ L ++G +I Sbjct: 1 MKIIVAKNVGFCFGVERAIRTVENLLN-EGKRVVTDGEIVHNRQVMEDLLKKGL----KI 55 Query: 61 SEVP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 S P DG + + AHG+ + + + V D TCP+V ++ S RG+ I+ Sbjct: 56 SSDPTDGDVFVVRAHGIPEEKLEKLRKIYPEVVDLTCPIVFQLFRTAREYSSRGK-LIVF 114 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVI 178 G HPE+ MG +P V K K EEK + F++QTT S+D+ + + Sbjct: 115 GKRDHPEMVALMGY------------APAIVTKKPFKTEEKNVVFLSQTTSSLDEYREFV 162 Query: 179 DALRK--RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 + K F K + + IC T R+ V+ L++ ++ +VVG K+SSN+ +L LA Sbjct: 163 SEMIKMNNFEKAI--YLNTICPVTVEREREVKELSKICDLSVVVGGKHSSNTGKLFRLAS 220 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 R RA ++ +I E+ VK V V +G S P L++NVV +L+++ G Sbjct: 221 R-NSRAIWVESPDEIPEDVVK-YGTVCVFSGTSTPVSLIENVVRKLEEMEG 269 >UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; SSU ribosomal protein S1P n=2 Tax=Bacteria RepID=C1SLB2_9BACT Length = 848 Score = 130 bits (327), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 81/286 (28%), Positives = 150/286 (52%), Gaps = 10/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +A+ GFC GV+RA+S+VE+ + +Y ++HN +V E G Sbjct: 6 VEIFIADHAGFCFGVERAVSLVEDTSKQFTG-VYTLGPIIHNPQIVSKFAENGIGVCYNP 64 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV + ++ +HGV++ SR + V DATCP V K + G ++ G Sbjct: 65 EEVNEDNTVVVRSHGVTKETYATLASRKVNVVDATCPFVKKAQNSAKKLGNEGAVVVVYG 124 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTV-KNEEKLSFMTQTTLSVDDTSDVID 179 HPEV+ + + Y++ S DV + +V +E + + QTT + + + + Sbjct: 125 EKNHPEVKSIVSFIDS----RYVIVS--DVGEASVLPDENCYALVAQTTQNSESFDKIAE 178 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+ + K++ K+ IC AT+ RQ + LA++ ++++V+G +NS N+ RL E+ + + Sbjct: 179 ILKTKCDKLI--IKNTICNATSLRQASAIDLAKKVDIMVVIGGRNSGNTTRLYEICKNIC 236 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 I+ +++++E + VG+TAGAS P LV+ V+ L+++ Sbjct: 237 ANTHHIETKEELKKEIFDGCRKVGITAGASTPGYLVEEVIEFLKEV 282 >UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XKP1_CALS8 Length = 662 Score = 129 bits (324), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 89/287 (31%), Positives = 144/287 (50%), Gaps = 10/287 (3%) Query: 1 MQILLANPRGFCAGVDRAIS-IVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV+RA++ ++ A A + V ++HN YV++ L+E IE Sbjct: 1 MIIKVAKNAGFCFGVERAVNGVIAWAKANKDKSVKVYGMLIHNSYVIEKLKELNVKVIEN 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I+E+ I+ +HGVS +E + R V+D TCP V K+H V S G + I++ Sbjct: 61 INEIEKDDIVFIRSHGVSMEEFSEIEKRASKVYDFTCPYVKKIHEIVRENSENGLDVIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYL--VESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 G HPEV+G +G + + +E D +N + QTT ++ Sbjct: 121 GDINHPEVKGIIGHVEKDRKCIVIDSLEKAKDAISQLGRN---AVVVCQTTFDNAKWCEI 177 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + + V D +C AT RQE + LA +V+LV+G K SSN+N+L + + Sbjct: 178 KEYIENNTEYKVF---DTVCKATITRQEEAKVLALDVDVMLVIGDKKSSNTNKLYQAVKD 234 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + K F I+ +D++ +VK +G+TAGAS + +V L++ Sbjct: 235 I-KPTFFIERPQDLEGIDFTKVKKIGITAGASTSQEQISEIVEILEK 280 >UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H149_9FIRM Length = 703 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 85/299 (28%), Positives = 145/299 (48%), Gaps = 31/299 (10%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG--AIFIEQ 59 +I+L GFC GV AI + A A I+ +++HN+ VV+ L ERG A+ ++ Sbjct: 12 KIILVEGSGFCFGVKNAIQKAKRARAELDKEIFTLGDIIHNKVVVEDLNERGITAVGEDE 71 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I + G+ ++ +HG S+A +A D + DATCP V ++H V S +G I++ Sbjct: 72 IETLKRGSNIVVRSHGASRAFFEKAAGLDFNLIDATCPYVLRIHTLVKNESLKGRVIIIV 131 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTL--------- 169 G+ HPEV G G + + ++ ++ K + K + + QTT+ Sbjct: 132 GNEEHPEVAGISGWCCGEKAVISENSKKSEIEEICEKYKGKEMVVVGQTTIKQEAYERVC 191 Query: 170 ----SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNS 225 SV+D ++V+D L C TT RQE A+ + ++V+G S Sbjct: 192 EVIKSVNDHAEVMDTL---------------CSITTTRQEKAFECAKNVDAMIVIGDSKS 236 Query: 226 SNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 SNS +L E+ + K F I++ D+ + + +GV A ASAP +++ V+ + + Sbjct: 237 SNSLKLYEICSSVNKNTFFIENKSDLPLKKLSNCTTIGVVASASAPGQIIREVMVIMNE 295 >UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Dehalococcoides RepID=ISPH_DEHSC Length = 284 Score = 128 bits (321), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 90/297 (30%), Positives = 151/297 (50%), Gaps = 23/297 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ A+ GFC GV RAI+I+E + G + +VHN+ V++ L G ++ I Sbjct: 1 MKVECASNIGFCFGVRRAINILEKTASERGG-VETLGALVHNQQVLNRLSGMGVRVVKNI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G + S+HGV AV E KS+ L + D TCP V + + R G +++ G Sbjct: 60 DDIS-GRTVAISSHGVGPAVLAELKSKGLEIVDTTCPFVKRAQVAAKRFHDAGFFTVIYG 118 Query: 121 HAGHPEVEGTMGQYS-------NPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTT-LSVD 172 HPEV+G +G NP+G DD+ L+ + ++QTT + Sbjct: 119 DVNHPEVKGILGWAGGNGLATLNPQG-------LDDIPDLS----RYIGVLSQTTQIPTG 167 Query: 173 DTSDVIDALRKRFPKIVGPR-KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 TS V + + + K R D +C+ +RQ A LA + +++LV+G NS+N+ L Sbjct: 168 FTSFVKNVIDQALVKDAEIRIADTLCHDIRDRQAAALELAGRVDLMLVIGGHNSANTRHL 227 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 +L + + LI+ A ++Q +W+K V +G+T+GAS + + V + L +L G Sbjct: 228 LDLCKTV-SNTHLIETASELQTDWLKGVSRIGITSGASTDETTISEVCSYLDRLSAG 283 >UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Deltaproteobacteria RepID=A0LJ95_SYNFM Length = 580 Score = 127 bits (318), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 88/287 (30%), Positives = 149/287 (51%), Gaps = 9/287 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY--GAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M++L+A GFC GV A+ + A+ G I ++HNR V+ L +G + Sbjct: 1 MKVLVAKTAGFCKGVRDALEVTLGAIKNQQDGENICTFGPLIHNRQVLAMLEAKGIREVN 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +I D ++I AHG+ R T+ DATC V KVH + R +RRG +++ Sbjct: 61 EIEGCADRKVVI-RAHGIPPETRQTLHRLGATLLDATCKRVAKVHAAIKRHARRGYYTVI 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G A H EV G MG EG ++ + + +L + E L + QTT + + ++ Sbjct: 120 VGDADHAEVIGLMGY---TEGRGVVINRVEQLNELPAEWENVL-LVAQTTQNEEVFQEIQ 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + K++PK G K+ IC +T RQ VR + E +++VG +S N+ RLA++A+ Sbjct: 176 EEFLKKYPK--GKVKNTICDSTHERQTEVREMCSLVEAMVIVGGFHSGNTLRLAQVAREC 233 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++ ++ + + + VGV+AGAS P+ L++NVV L+ + Sbjct: 234 EIPTYHVETEAELNPQELAKYSRVGVSAGASTPNWLIRNVVRFLESI 280 >UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Verrucomicrobia RepID=B4CZC4_9BACT Length = 287 Score = 126 bits (317), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 91/295 (30%), Positives = 146/295 (49%), Gaps = 27/295 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA G C GV AI+ E LA G P+ + E+VHN V + L G Sbjct: 1 MKIQLAEHYGLCFGVRDAIAQAEE-LATRG-PLTILGELVHNPVVRERLARHG------- 51 Query: 61 SEVPDGAI----------LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 V +GA+ ++ +AHG S R E ++ V D TCPLV + H ++ Sbjct: 52 --VREGALDDRDSAQSTQVMITAHGASDKARGEWRNAGFGVADGTCPLVLQAHEKLRALV 109 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLS 170 +G ++IG GH EV G G + + ++ES +D+ L +L ++QTT Sbjct: 110 EQGFVPVVIGKRGHVEVNGLTGDFPD----ACIIESAEDLANL--PTAARLGVISQTTQP 163 Query: 171 VDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 + ++DA+R P D +C T NRQ A+R L E+ + ++VVG +NS+N+ + Sbjct: 164 SEKVLALVDAIRIARPASEVRFCDTVCQPTKNRQSALRKLIEECDTLVVVGGRNSNNTLQ 223 Query: 231 LAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 L A G+ ++ A++++ +W + + VG+TAG S V V RL+ + Sbjct: 224 LVAAATVAGRAVHHVERAEELRPDWFRAARVVGITAGTSTLKETVATVRIRLEAI 278 >UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga lettingae TMO RepID=ISPH_THELT Length = 278 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/290 (28%), Positives = 160/290 (55%), Gaps = 25/290 (8%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M+I++A GFC+GV RA+ + + + IY E+VHN+ VVDSLR+RG +++ Sbjct: 1 MRIIVAEDIGFCSGVRRALKMTLSEIN-ENEKIYTLGEIVHNKTVVDSLRKRGVNVLQEN 59 Query: 60 -ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 I E + LI AHG+S+ E + + D TCP+V + +R + G ++ Sbjct: 60 IIPEDAKNSSLIIRAHGISRDQLFELQKVFKKIVDTTCPIVHNLFQTASRIHQEGYRIVV 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEE---KLSFMTQTTLSVDDTS 175 G HPE+ G Y+ ++ +T+K E ++ M+QTT+S+D+ Sbjct: 120 FGKESHPEMSALKG---------YVKDAT-----ITLKPPELSGRICIMSQTTMSIDEFY 165 Query: 176 D-VIDAL-RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 D V+ ++ + +F +I + +C T R++ + +A+Q ++++++G KNSSN+++L + Sbjct: 166 DFVVKSISQSKFSEI--RIINTVCEITARREKEAQKIAKQVDLMIIIGGKNSSNTSKLTK 223 Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 +A + RA I+ +++ + +V+ +G+T G S P+ V+ V+ +++ Sbjct: 224 IASKFT-RAIQIETPEEVDKINFDKVEMIGITTGTSTPEEDVKTVIDKIK 272 >UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammaproteobacteria RepID=C0AZ30_9ENTR Length = 97 Score = 125 bits (315), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 61/94 (64%), Positives = 72/94 (76%) Query: 223 KNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 KNSSNSNRLAELAQR GK ++LID +DI E WV VGVTAGASAPDILVQ V+ RL Sbjct: 4 KNSSNSNRLAELAQRAGKPSYLIDSFEDIDESWVANANIVGVTAGASAPDILVQQVLERL 63 Query: 283 QQLGGGEAIPLEGREENIVFEVPKELRVDIREVD 316 + G + + L GREENIVFEVPKELR+D + ++ Sbjct: 64 KTFGADDVVELSGREENIVFEVPKELRLDYKVIE 97 >UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bacteroidales RepID=ISPH_AZOPC Length = 287 Score = 125 bits (313), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 80/280 (28%), Positives = 133/280 (47%), Gaps = 14/280 (5%) Query: 10 GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQISEVPDGA 67 GFC GV AI E L I +Y ++VHN V L+++G I E++ + + Sbjct: 11 GFCFGVMSAIQRAEKEL-ITNDELYCLGDIVHNSQEVVRLQKKGLKIINHEELGRIYNKK 69 Query: 68 ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA----SRRGEESILIGHAG 123 +L F AHG + A + + DATCP+V ++ ++ + + + +L G + Sbjct: 70 VL-FRAHGEPPSTYEVANQNSIHIIDATCPVVLQLQKKIQKIYQSFANTKSQIVLFGRSK 128 Query: 124 HPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 H EV +GQ G ++ES +D+ ++ + + +QTT+ VDD +++ + Sbjct: 129 HAEVSALVGQ---TNGNAIVIESKNDIQQIDFA--KNIYLFSQTTMFVDDFKEIVKEIEN 183 Query: 184 RFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 + I+ + IC+ NR +R A Q ++L V NSSN L +R Sbjct: 184 KIIHPIIFSSFNTICHQMVNRINHIRKFAVQHNLLLFVAGDNSSNGTILFNECRRANLNT 243 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 +LI D KDIQ EW +K VG+ S P L++ + L Sbjct: 244 YLISDEKDIQSEWFNGIKSVGICGATSTPKWLMEKIALSL 283 >UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Thermotogaceae RepID=ISPH_THESQ Length = 275 Score = 122 bits (306), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 90/290 (31%), Positives = 155/290 (53%), Gaps = 24/290 (8%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VE L G + E+VHN+ V++ L ++G ++ Sbjct: 1 MKIVVAKNIGFCFGVERAIRTVEELLD-EGKKVVTDGEIVHNKQVMEQLTKKG---LKVS 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SE+ DG + + AHG+ + E K V D TCP+V+++ R ++ + I+ G Sbjct: 57 SEMTDGEVFVVRAHGIPKDRLEELKKIFPEVVDLTCPIVSQLFKTAQRYAKE-RKVIVFG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVID 179 HPE+ G +P V K+ K EEK + F++QTT S+++ + + Sbjct: 116 KEDHPEMVALRGY------------APAIVTKVPFKFEEKKVVFLSQTTSSLEEYKEFVA 163 Query: 180 ALRK--RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 A+ + F + V + IC T NR+ V L++ ++ +VVG K+SSN+ +L +A + Sbjct: 164 AMIRMNEFEEAVFL--NTICPVTVNREREVEELSKICDLSIVVGGKHSSNTGKLFRIASK 221 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K + I+ ++ + VK V V +G S P+ L++NVV +L+++ G Sbjct: 222 HSKTIW-IESPDELPADVVK-YGTVCVFSGTSTPNSLIENVVRKLKEMEG 269 >UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CWY2_HALOH Length = 678 Score = 120 bits (301), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 74/254 (29%), Positives = 128/254 (50%), Gaps = 10/254 (3%) Query: 32 PIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTV 91 P+Y ++HN VV L+E G ++ + ++ D ++I +HGV + +A+ + L + Sbjct: 12 PVYTLGPLIHNPQVVKRLKEMGIESLDSL-DIIDNGVIIIRSHGVPPDIIEKARQKGLHI 70 Query: 92 FDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVW 151 DATCP V +G ++I+ G HPEV G G N ++ S ++ Sbjct: 71 IDATCPYVKNAQKYARELVDKGYQTIIFGDRDHPEVIGINGAARNES---IIISSEKEIK 127 Query: 152 KLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR-KDDICYATTNRQEAVRAL 210 + + + K+ + QTT S ++ + P++ R + IC T RQ++ L Sbjct: 128 DINLSS--KVGLIAQTTKSPASFQKIVSYI---LPEVKELRIYNTICRTTETRQKSAVDL 182 Query: 211 AEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASA 270 A Q + + V+G KNS+N+ RLAEL G + I+ A +I +K +G+TAGAS Sbjct: 183 ARQVDAMFVIGGKNSANTTRLAELCAETGTPTYHIETAGEIDFRQLKSYNKIGITAGAST 242 Query: 271 PDILVQNVVARLQQ 284 PD L++ V+ + + Sbjct: 243 PDWLIKEVIEAMSE 256 >UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium URE4 RepID=C0JZX4_9BACT Length = 288 Score = 119 bits (298), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 85/285 (29%), Positives = 134/285 (47%), Gaps = 16/285 (5%) Query: 10 GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAIL 69 GFC GV RAIS E L +Y +VHN +D L G + I +VP+G + Sbjct: 11 GFCGGVIRAISQAERFLQ-ESDHLYSLGAIVHNEAELDRLGAEGLRTVASIPDVPEGETV 69 Query: 70 IFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES------ILIGHAG 123 + AHG + +A+ R L V D TCP+V K+ + A R ++ G G Sbjct: 70 LIRAHGEPPSTYADARRRGLVVIDCTCPVVLKLQEHIREAYARLHADGLHGTLLIFGKIG 129 Query: 124 HPEVEGTMGQYSNPEGGMYLVESP---DDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G +GQ +G +VE+ +D + + + +QTT S + +++ D Sbjct: 130 HAEVLGLLGQV---DGDAIVVENRAMLEDALP-AIDFSQPVEIFSQTTKSPAEYAEICDR 185 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R ++ D IC NR E + A A +++L V ++SSN L +L R+ Sbjct: 186 VRSLGDRVT--VHDTICAQVANRHEHLAAFARAHDLILFVAGESSSNGRVLFDLCHRLNP 243 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++ I DI WV++ VGV S P L++ V +++L Sbjct: 244 RSYRIGAPADIDPAWVRDGDHVGVCGATSTPQWLLEMVAEAVREL 288 >UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0033 Length = 284 Score = 117 bits (294), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 80/287 (27%), Positives = 147/287 (51%), Gaps = 9/287 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I LA GFC GV+RA+++ + ++ + I+ ++HN +V + L+ +G +++ Sbjct: 2 IKLAKSAGFCFGVERAVNLAYSNASL--SNIFTFGPIIHNDFVTNDLKLKGVEIAYELT- 58 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 P +I +HGV + + +A + + DATCP V K+H V + G+ I+IG Sbjct: 59 -PRIKNVIIRSHGVGENIYKQADHLGINIIDATCPYVKKIHNLVKQHIILGQSIIIIGDK 117 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPE+ G G ++N + E ++ L N + + QTT + + +I L Sbjct: 118 LHPEIIGING-WTNDNAIIIKDEFDSNIPLL--DNTKSYFVVAQTTYKQEVVNRIIQLLE 174 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 + I IC TT RQ+ R+LA+ + +++VG +NSSN+ +L E+ K + Sbjct: 175 EN--HITFNYVHTICSTTTKRQQEARSLAKNVDTMIIVGGRNSSNTKKLFEICLSECKNS 232 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 I++A ++ + + +G+TAGAS P ++ +V++ + GE Sbjct: 233 LCIENASELAKIKFNKDSDIGITAGASTPKYIIDDVISYINNTIKGE 279 >UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DRD7_9ACTO Length = 407 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 122/234 (52%), Gaps = 5/234 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA +C G R + +VE+ L ++V ++ + +LRERG + + + Sbjct: 116 RVLLAGGEPWCVGGRRVVELVESTLDDGAELVHVVGDLAASPERRVALRERGVVPVTALD 175 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVPDGA ++ A G+ + R +A R + + D TCP + +V R + RG+ +L+G Sbjct: 176 EVPDGARVVVGAAGIPEEQRVKAAKRGVRIVDGTCPHIASGKAQVRRYAERGDAVVLVGQ 235 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E GQ + +VE+ DV ++ + + +S + ++++ ++ AL Sbjct: 236 RGHASTEALSGQAPD---ATLVVETTADVEQM--RGGDGVSAVPVPSMAIGAVVPMLAAL 290 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 R+RFPK+ D CY T +R VR LA A+VV V+G S + RL ++A Sbjct: 291 RRRFPKLPVQHPDQWCYQTQDRLATVRELAGTADVVFVLGPPESPETVRLLDVA 344 >UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8C2Y3_THAPS Length = 462 Score = 114 bits (286), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 93/350 (26%), Positives = 164/350 (46%), Gaps = 65/350 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A+ + G +++ +E++HN V D L + FIE+ Sbjct: 105 VKVYLAKDFGFCWGVERSIALAYEAVEHFPGKTVHITNELIHNPEVNDKLHDMNVQFIEK 164 Query: 60 I-------SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + S++ +G ++I A G S ++++ V D TCP V+KV V + R+ Sbjct: 165 LGEGKKDFSKIGEGDVVILPAFGASFEEMTLMNNKNVEVVDTTCPWVSKVWNTVDQHQRK 224 Query: 113 GEESILIGHAGHPEVEGTMGQYSN-------PEGGM---YLVESPDDVWKLTVKNE---- 158 G S++ G GH E T+ + E M Y++ D L + Sbjct: 225 GLTSVIHGKYGHEETVATVSFCEDYICVKDIKEAEMVADYIINGGDKEKFLKYFEKAVSK 284 Query: 159 --------EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATTN 202 +K+ QTT+ +T + ++K K GP D IC AT Sbjct: 285 GFDPDTMLDKVGLANQTTMYKKETRAIGQLMQKAMMKKFGPVNAKDHYLEFDTICDATQE 344 Query: 203 RQEAVRALAEQA-----EVVLVVGSKNSSNSNRLAELAQRMGKRAFLID----------- 246 RQ+A+ L E + + +LVVG +SSN+ L E+ ++ G R+F I+ Sbjct: 345 RQDAISDLVENSDELGLDFILVVGGWDSSNTAHLLEIPEKAGVRSFHINKSECIGADNTI 404 Query: 247 -----DAKDIQEEWVKEVK------CVGVTAGASAPDILVQNVVARLQQL 285 D + + E+++++++ +GVT+GAS PD VQ+ + ++ L Sbjct: 405 THRTVDGEIVTEKFIEDIENKDKKLVMGVTSGASTPDKAVQDSLDQIFML 454 >UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PSH0_9SPIO Length = 333 Score = 113 bits (283), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 89/282 (31%), Positives = 132/282 (46%), Gaps = 10/282 (3%) Query: 10 GFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAI 68 G+C GV RA+ V ALA Y +Y ++HN + L +G + E+ I Sbjct: 55 GYCMGVRRAVDAVYRALADYPDKTVYTYGPLIHNPVTMRLLEAKGVHIVNPDEELKPQII 114 Query: 69 LIFS----AHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGH 124 AHG+S R E + DATCP V + A+ S++G IL G H Sbjct: 115 PQSPIIIRAHGISPQKRQELIDCGAIIIDATCPKVIASQFKAAQYSQKGYTVILAGDRNH 174 Query: 125 PEVEGTMGQ-YSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 E+ G G S P G V++ + L + + QTT+ D+ + D L K Sbjct: 175 GELIGIRGYVLSVPNGKCITVQTAAEAETLQDDGAPTV-LIAQTTIKRDEYRAIADILHK 233 Query: 184 RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAF 243 + + + IC AT RQEA+ L ++ + +LVVG NS+N+ RL + A GK A+ Sbjct: 234 KIAHLT--VLETICSATDERQEALLELVKEVDAILVVGGSNSANTRRLLQTAVDSGKPAW 291 Query: 244 LIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 L + A DI E V +G+ AGAS PD + + + L +L Sbjct: 292 LAETAADIPSE-VCCYHTIGLAAGASTPDSSIDTIESILDKL 332 >UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Desulfovibrionales RepID=ISPH_DESVH Length = 290 Score = 112 bits (280), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/294 (29%), Positives = 137/294 (46%), Gaps = 13/294 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL------AIYGAP---IYVRHEVVHNRYVVDSLRE 51 M ++ A GFC GV A+ ++ + A G+P I ++HN V+++ Sbjct: 1 MNVIRARTAGFCMGVSLALRKLDREVDRAEEKAAQGSPRCRIATFGPIIHNPQVLEAYAG 60 Query: 52 RGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 G + Q+ EV G ++ AHGV Q +SRD V DATCP V K + + R Sbjct: 61 MGVRCLRQVDEVEAGDHVVIRAHGVPQQQEKALRSRDAVVVDATCPKVKKAQLGIEEQCR 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G +L G A HPEV G + Y+ G + S D++ L ++ E + QTT Sbjct: 121 AGRTLLLFGEAEHPEVRGLL-SYAGE--GALVFGSVDELEGLPLQPETEYFLAAQTTQDR 177 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 L +R V P + IC AT RQ+ +A + + ++VVG +S N+ RL Sbjct: 178 VAFEVARAWLHERLGHEV-PVLETICDATRLRQQEAIDIARKVDAMVVVGGFDSGNTRRL 236 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 A++A G +++ + E ++ +G+TAGAS P ++ L+ L Sbjct: 237 ADVAAAQGVFTVHVENESQLPVEQLRGCGIIGLTAGASTPKSIIDATQRFLESL 290 >UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Brachyspira hyodysenteriae WA1 RepID=C0R0R2_BRAHW Length = 581 Score = 112 bits (280), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 83/280 (29%), Positives = 139/280 (49%), Gaps = 8/280 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE-- 58 M + + GFC GV A+ + + + IY+ ++HN +D L G E Sbjct: 1 MNVDIGKFAGFCDGVKYAVENTFSQASKKNSDIYIDGHLIHNPQTLDMLENIGVKTYEDD 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + V DG +I AHG+S R S + + TC V K+ V + S G I+ Sbjct: 61 EDMSVLDGKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKYSSLGYRVIV 120 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IG+ HPE+ G G Y++ +Y+V +D+ KL + +K + QTTL + Sbjct: 121 IGNPVHPEIVGVCG-YAD---DVYVVYKDEDLNKLP-NDSKKALIVAQTTLQKSAFDKFV 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 ++ ++ K+ IC AT RQ V +A++ +VVLV+G SSN+ L +A + Sbjct: 176 AQIQDKYKDTEIIIKNTICAATEQRQNEVLEIAKRNDVVLVIGGSESSNTRNLYNIASSI 235 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 K AF ++ +D+++ + K +G+ AGAS PD L++++ Sbjct: 236 -KPAFYVEYKEDLEKIDLSNYKNIGIMAGASTPDWLIEDI 274 >UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Brachyspira murdochii DSM 12563 RepID=C1QCD1_9SPIR Length = 583 Score = 112 bits (279), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/276 (31%), Positives = 136/276 (49%), Gaps = 16/276 (5%) Query: 10 GFCAGVDRAISIVENALAIYGA-----PIYVRHEVVHNRYVVDSLRERGAIFIE--QISE 62 GFC GV A VEN + IY+ ++HN +D L G E + Sbjct: 10 GFCDGVKYA---VENTFSQAAKNNNNDDIYIDGHLIHNPQTLDMLENIGVKTYEDNEDMS 66 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 V + +I AHG+S R S + + TC V K+ V + S G I+IG+ Sbjct: 67 VLNNKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKHSSLGYRIIVIGNP 126 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPE+ G G Y+N +Y+V +D+ L + +K QTTL +D ++ Sbjct: 127 KHPEIIGVCG-YAN---DVYVVYKDEDLNNLP-NDTKKTLIAAQTTLQKSVFDKYVDKIK 181 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +++P K+ IC AT RQ V +A++ + VLV+G SSN+ L +A + K A Sbjct: 182 EKYPDTEIIVKNTICEATEQRQNEVLEIAKRNDAVLVIGGSESSNTRNLYNIASSI-KPA 240 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 F ++ +D+++ + + K VG+ AGAS PD L+++V Sbjct: 241 FYVEYKEDLEKIDLSKYKNVGIMAGASTPDWLIEDV 276 >UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8P7_COPPD Length = 282 Score = 111 bits (278), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 87/285 (30%), Positives = 134/285 (47%), Gaps = 26/285 (9%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++ LA P+G C GV R+I + L +G ++ H +VHN V+ L + G I E + Sbjct: 7 ELHLAFPQGPCFGVKRSIELCRKILEKHGT-VFAVHPLVHNEIVMADLAKHGLILEEDVE 65 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 ++P + ++ SAHG + V K ++ V DA CPLV VH + A + + ++G Sbjct: 66 KIPSNSWVVLSAHGTPKDVLERLKEKNCKVVDAVCPLVLFVHKKALEAVKNFGKVNIVGD 125 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI--- 178 + H E+ + PEG Y++ P+ KL +++ + Q+T T +I Sbjct: 126 SQHQEIRALTSEL--PEGS-YVLCGPEG--KLA---DKRFPVVFQST-----TDPIILHE 172 Query: 179 -DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 DA R D IC AT RQ+A L E + ++++GS S+NS LA A Sbjct: 173 LDAEGYRI-------MDTICTATKGRQQANAQLIENCDALIILGSSTSANSRHLAAKASA 225 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 GK L D D + VG+ AGAS P LV R+ Sbjct: 226 SGKPVLLTLDL-DEAASFALNYDIVGIIAGASTPLDLVYQAYDRI 269 >UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPH_KOSOT Length = 298 Score = 110 bits (276), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 149/304 (49%), Gaps = 25/304 (8%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV+RA+ + L V ++VHN V+ L++ G + Sbjct: 1 MKIVLAESLGFCYGVNRAVEATKRLLK-EKRDARVIGDIVHNEIVMKKLKDMGLKVYPDL 59 Query: 61 SEV-----PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + + ++ I AHG S V + K R V D TCP+V V ++G Sbjct: 60 SSIDFSDTAENSVAIIRAHGASPDVEDFLKRRFGYVVDLTCPIVYNVFSLAKDLEKKGYF 119 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK-----LTVKNEEKLSFMTQTTLS 170 ++ G H EV+ G+ ++ YL+ P ++ L K +K++ ++QTT++ Sbjct: 120 IVIFGKKDHAEVKALCGRLND-----YLIVEPGYDFETIKAFLREKKPKKVALISQTTMN 174 Query: 171 VDDTSDVIDALRKRFPKIVGPR---KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSN 227 S+ + L ++ K+ G + IC T NR++ LA+ + V+VVG K SSN Sbjct: 175 ----SESFEKLAEKLLKLEGIEVSVNNTICNVTINREKMAIHLAQTCDAVVVVGGKRSSN 230 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 + +LA++ + GKRAF + + + + + + + VG+ +G S P + ++ ++ Sbjct: 231 TGKLAKIVESHGKRAFHVQNPEQLPDLSI--YRKVGIISGTSTPKEQILKILDYIKFTYE 288 Query: 288 GEAI 291 GE I Sbjct: 289 GEVI 292 >UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Bacteroidales RepID=ISPH_PARD8 Length = 290 Score = 110 bits (275), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 131/287 (45%), Gaps = 14/287 (4%) Query: 10 GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQISEVPDGA 67 GFC GV AI E L +Y ++VHN V+ L G I E +S + D Sbjct: 11 GFCFGVVTAIESAERELG-NTDTLYCLGDIVHNSLEVERLEHMGLHTIDHEGLSRLRDRK 69 Query: 68 ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVT----KVHMEVARASRRGEESILIGHAG 123 +L+ AHG + AK ++T+ DATCP+V K+H + ++ G G Sbjct: 70 VLL-RAHGEPPSTYALAKRNNITIIDATCPVVLRLQRKIHKCYQETRANNTQLVIYGKKG 128 Query: 124 HPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 H EV G +GQ EG ++E +D+ +L +S +QTT S+D V+ +++ Sbjct: 129 HAEVNGLVGQ---TEGTAIVIEKIEDLDRLDFT--RAISLFSQTTKSLDGFKAVVAEIKQ 183 Query: 184 RFPKIVG-PRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 R + V D IC NR ++A A + V V + SSN L E ++ Sbjct: 184 RMAEGVEFNYYDTICRQVANRLPNIKAFASSHDWVYFVAGRKSSNGKMLFEECRKANPNT 243 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 I + +I E + V+ VGV S P L++ V R+++L E Sbjct: 244 LFISEVSEITEPLPEGVRRVGVCGATSTPKWLMEEVAVRIKELNASE 290 >UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=30 Tax=Bacteroidetes RepID=ISPH_CYTH3 Length = 293 Score = 110 bits (274), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 147/296 (49%), Gaps = 21/296 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 M +++ G+C GV+ AI + E+ +A G P++ ++VHN V+ L ++G I E Sbjct: 1 MDVIIDKNSGYCFGVEFAIQMAEDEMAT-GEPLFCLGDIVHNSMEVERLAKKGLKIIDRE 59 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV-----ARASRRG 113 ++ ++ D +LI AHG A ++ + DA+CP+V K+ V A S+ G Sbjct: 60 ELKKLSDCKVLI-RAHGEPPETYQLALENNIELVDASCPVVLKLQNRVKASFDAIDSKDG 118 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD- 172 + ++ G GH EV G GQ + ++ + D+ K+ E+ ++ +QTT S Sbjct: 119 Q-IVIYGQEGHAEVIGIAGQTGDK---AIVITTEKDLDKIDF--EKPVTLYSQTTKSTQG 172 Query: 173 --DTSDVIDALRKRFPKIVGPR---KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSN 227 D+I+A K V D IC +NR+ +R +++ +VV+ V K SSN Sbjct: 173 FYKMKDLIEARVAEAGKNVDENFEYNDSICRQVSNREPQLRKFSKEFDVVIFVSGKKSSN 232 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 L + ++ +R++ +++ +I+ W++ VG+ S P L++ V +Q Sbjct: 233 GKALYGVCKQENERSYFVENETEIEPSWIRATDNVGICGATSTPMWLMEKVQNYIQ 288 >UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema denticola RepID=ISPH_TREDE Length = 289 Score = 110 bits (274), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 86/288 (29%), Positives = 147/288 (51%), Gaps = 26/288 (9%) Query: 10 GFCAGVDRAISIV-----ENALAIYGAPIYVRHEVVHNRYVVDSLRERG--AIFIEQISE 62 G+C+GV RA+ V EN G +Y ++HN + L++ G I E +E Sbjct: 10 GYCSGVRRAVDTVLKLAKENTENKSG--LYTFGPLIHNPSTMLRLKQMGVRTIDTENFTE 67 Query: 63 VPD--GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES--IL 118 D ++++ AHG+ + ++E + V DATC ++V A A + EE+ IL Sbjct: 68 DEDYKDSVIVIRAHGIPPSKKSELEKSGAKVIDATC---SRVKASQALAKKHSEEAFVIL 124 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLS----FMTQTTLSVDDT 174 G H E+ G EG +V++ ++ + + + + + QTT+ + Sbjct: 125 AGDKNHGELISIAGY---AEGKCLIVQNAEEAALIDLPSSLSANGSAVLIAQTTIKESEY 181 Query: 175 SDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 + AL+KR + + IC AT++RQ A++ LA + + +LV+G KNS+N+ RL + Sbjct: 182 EAIASALKKRISDL--KVFNTICPATSDRQAALKKLAYEVDALLVIGGKNSANTKRLFQT 239 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 A K A+LI+DA +I +E + +G+TAGAS PD ++ V +L Sbjct: 240 AVDTKKPAWLIEDASEIPKE-IFSYSVIGLTAGASTPDFIIDEVEKKL 286 >UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 Tax=Phaeodactylum tricornutum RepID=B7FUL0_PHATR Length = 458 Score = 110 bits (274), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 94/345 (27%), Positives = 158/345 (45%), Gaps = 64/345 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A + +++ +E++HN V ++L+ + FIE+ Sbjct: 103 VKVYLAKDFGFCWGVERSIALAYEAAEHFPDRKLHITNELIHNPEVNENLKAKNVQFIEK 162 Query: 60 ISE-------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + + V DG ++I A G S + +++ + D TCP V+KV V + ++ Sbjct: 163 LGDGTKNFASVQDGDVVILPAFGASFEEMDYFDKKNVEIVDTTCPWVSKVWNTVDKHQKQ 222 Query: 113 GEESILIGHAGHPEVEGTMGQYSN-------PEGGM---YLVESPD-DVWKLTVKNE--- 158 G S++ G H E T + E M Y++ D D + +N Sbjct: 223 GLTSVIHGKYAHEETVATTSFCEDFICVKNFKEAEMVANYILNGGDKDAFMKHFENAVSE 282 Query: 159 --------EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTN 202 EK+ QTT+ +T + +K K GP K D IC AT Sbjct: 283 GFDPDKHLEKVGLANQTTMYKKETRAIGQLFQKTMMKKFGPVKSKEHYMEFDTICDATQE 342 Query: 203 RQEAVRALAEQAE-----VVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK-------- 249 RQ+A+ + E A+ +LV+G +SSN+ L E+ G RAF I+ A+ Sbjct: 343 RQDAIHDMVESAQKDGLDFILVIGGWDSSNTAHLLEIPVHAGIRAFHINRAECIGADNTI 402 Query: 250 ------------DIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 + E+ KEV +GVT+GAS PD VQ+ ++++ Sbjct: 403 THRTVDGEIVTTQLLEDMDKEV-VMGVTSGASTPDAAVQDSLSQI 446 >UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellularis PHE/MN1-00 RepID=Q1MQE5_LAWIP Length = 294 Score = 106 bits (264), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 134/291 (46%), Gaps = 27/291 (9%) Query: 1 MQILLANPRGFCAGVDRAI----SIVENA------LAIYGAPIYVRHEVVHNRYVVDSLR 50 MQ++ A G C GVD A+ +EN +YG ++HN V+ + Sbjct: 9 MQVIRAKTAGTCWGVDLALRKLSQSIENKEKANTRFVMYGL-------IIHNPQVIVEYK 61 Query: 51 ERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 +G I ++ I EV G +I AHG+ + + + DATCP V K + +A A+ Sbjct: 62 AQGVICVDSIEEVRAGDTVIIRAHGIPIYEEQQLTDIGINLIDATCPKVKKTQLAIANAT 121 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLS 170 +L G A HPEV+G + S +G ++ ++ V + + +QTT Sbjct: 122 NSETILLLFGEANHPEVKGLI---SYSQGPFHVFDTKQFVEDFDNSQNKTIVLASQTTQD 178 Query: 171 VDDTSDVIDALRKRF--PKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 ++ + L ++ P I+ + IC AT RQ + ++ EQ ++VVG S N+ Sbjct: 179 EITFKEIQEILHQKGIQPVIL----NTICDATYKRQRELLSITEQVNTMVVVGGFTSGNT 234 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQ-EEWVKEVKCVGVTAGASAPDILVQNV 278 RL EL++ G + F I+ + + + +G+T GAS P L+ V Sbjct: 235 RRLVELSKAKGIKTFHIETVDALYGNNELDQNDIIGLTGGASTPKQLIDKV 285 >UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Prevotella RepID=D1Y0F8_9BACT Length = 304 Score = 105 bits (261), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 135/299 (45%), Gaps = 30/299 (10%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 +QI + + GFC GV AI E LA G +Y ++VHN V+ L G + I E Sbjct: 2 LQIEIDSGSGFCFGVTTAIKKAEEELA-KGTKLYCLGDIVHNSMEVERLETNGLVTIDHE 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVH--------------- 103 Q+ ++ + +L+ AHG AK ++ + DATCP+V + Sbjct: 61 QMKKLHNVKVLL-RAHGEPPETYELAKRNNIEIIDATCPVVLALQRRIKKQYESKLDDKL 119 Query: 104 ----ME-VARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNE 158 ME V ++ G + ++ G GH EV G +GQ + ++E +DV KL + Sbjct: 120 EDKQMEFVPESTSVGSQIVIFGKNGHAEVLGLVGQ---TKSEALIIEKFEDVKKLNFTKD 176 Query: 159 EKLSFMTQTTLSVDDTSDVIDALRKRF-PKIVGPRKDDICYATTNRQEAVRALAEQAEVV 217 + +QTT S+++ +I+ ++ P D IC NR + A + +V+ Sbjct: 177 --IYLYSQTTKSLNEFHQIIEYIQSHIDPSAKFQSFDTICRQVANRMPNISTFATRHDVI 234 Query: 218 LVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQ 276 + V K SSN L + R++ ++ A +I W + V VG+ S P L++ Sbjct: 235 IFVAGKKSSNGKVLFHECLDVNPRSYQVECADEIDMSWFEGVNTVGICGATSTPKWLME 293 >UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IE33_THEAB Length = 811 Score = 104 bits (259), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 146/291 (50%), Gaps = 29/291 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI +A GFC GV++A+++ + L G ++ ++VHN+ V++ L G + Sbjct: 1 MQIKIAKGIGFCFGVEKAVNVTKELLK-SGKNVFTDDDIVHNKQVMEELERLGLSY---- 55 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +G I + AHG+ + + K V D TC +V + V +G + ++ G Sbjct: 56 ---DNGDIYLIRAHGLPKEKIEKIKKEHRVV-DLTCNIVYNLFKTVEVYENKGYQVVVYG 111 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE+ + S + + +E L +K++ K+ +QTT+S D + + Sbjct: 112 KITHPEM---IALKSYSKNAIITMEP------LVIKSD-KIFVASQTTMSYKDFENFYNK 161 Query: 181 LRKRFPKIVGPRK--DDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 L+ I K + IC T NR+ V L+++ ++++VVG K+SSN+ +L +A + Sbjct: 162 LKD--ISIYNEFKVFNSICNITHNREIEVEKLSKEVDLMIVVGGKHSSNTRKLFNIASQH 219 Query: 239 GKRAFL--IDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K + ID+ K+I K V VG+ +G S P +V+ + A L++LGG Sbjct: 220 TKAIHIETIDEIKEIP----KGVDSVGIISGTSTPKEIVEEIAAGLKKLGG 266 >UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dunaliella salina RepID=C5H8E3_DUNSA Length = 474 Score = 99.8 bits (247), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 92/347 (26%), Positives = 147/347 (42%), Gaps = 69/347 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENAL-AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA G+C GV+RA+ + A A G I+V +E++HN V LRE +++ Sbjct: 112 VKLAKAYGYCWGVERAVRMAYEARRAFPGRSIHVTNEIIHNPEVNRRLREMDVNIVKEDP 171 Query: 60 -----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 S++ +G ++IF A GV + + + + D TCP V KV V +++ Sbjct: 172 QKGKDYSKIDNGDVVIFPAFGVGAPDMKYFRDKGVNIVDTTCPWVAKVWNSVDTYAKKKC 231 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLV----ESPDDVWKLTVKNEEKLSFM------ 164 SI+ G H E T + YL+ V +K ++ FM Sbjct: 232 TSIIHGKYSHEETVATASFAED-----YLIIKDLNEAQYVCDYILKGGDREEFMKKFSKA 286 Query: 165 -----------------TQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYA 199 QTT+ +T + L + + GP+ D IC A Sbjct: 287 VSKGFDPDVHLNRVGLANQTTMLKGETQAIGKMLERTMMEKFGPQNLQDHFMVMDTICDA 346 Query: 200 TTNRQEAVRALAEQA--EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ----- 252 T RQ+A+ + + +++LVVG NSSN++ L E+ G AF +D A I Sbjct: 347 TQERQDALYEITDDPTIDMMLVVGGFNSSNTSHLQEIPHNKGLPAFWVDTADRIDMASNS 406 Query: 253 -------------EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQL 285 E W+ E +GVT+GAS PD V+ V+ R+ ++ Sbjct: 407 IAHKLHYGELKVTENWLPEGPITIGVTSGASTPDRAVEEVLERVFRM 453 >UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HME7_FERNB Length = 854 Score = 98.6 bits (244), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/303 (26%), Positives = 145/303 (47%), Gaps = 33/303 (10%) Query: 4 LLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEV 63 ++ GFC GVD A+ + + L G ++ EVVHN+ V++ L+ G + Q Sbjct: 12 IIVGQYGFCFGVDNAVREIIDHLN-KGENLFTDGEVVHNKNVLEELKRLGLKYSPQ---- 66 Query: 64 PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAG 123 + + AHG+ NE S++ V D TCP+V + + S+ G + + G Sbjct: 67 -ENGTFVVRAHGLPPEKLNEI-SKNYKVIDLTCPIVQNLFALGKKLSKEGYKVVAFGKKD 124 Query: 124 HPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 H E+ G N + P + + K++ ++QTT S + + I+ ++K Sbjct: 125 HAEMVAFAGHVKNS----LVTTEPLPLL------DNKIAIISQTTSSSEKFALFIEEMKK 174 Query: 184 ----RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K++ + IC T R+E + LA+ V+VVG KNSSN+ +L E+A G Sbjct: 175 LNKGKEIKVI----NTICKVTIEREEQAKKLAQICNFVVVVGGKNSSNTKKLFEIAYNYG 230 Query: 240 KRAFL--IDDAKDIQE----EWVKEVKC--VGVTAGASAPDILVQNVVARLQQLGGGEAI 291 K + I++ +I+E E K+++ +G+ +G S V++++ L + GG + Sbjct: 231 KAVHIESINEINEIEEMLFREKSKDIQTIKIGLISGTSTYSKDVEHILKYLVKNYGGREL 290 Query: 292 PLE 294 +E Sbjct: 291 YME 293 >UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM5_9BACT Length = 543 Score = 97.4 bits (241), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 100/374 (26%), Positives = 156/374 (41%), Gaps = 84/374 (22%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + LL + GFC GV AI LA G +++ E++HN +V + L+ RG +++ Sbjct: 159 EYLLPSHFGFCLGVQNAIERAYETLAANPGKRVFMLSELIHNPFVNEDLQARGLKYLQSD 218 Query: 61 SEVP---------------DGAILIFSAHGVSQAVRNEAKSRDLTV--FDATCPLVTKVH 103 VP D I+I A G + R L + +DATC LV KV Sbjct: 219 KGVPLIEEATGRPYWDGLSDADIVIIPAFGARDEDKLRLIERGLPIRQYDATCMLVEKVW 278 Query: 104 MEVARASRRGEESILIGHAGHPEVEGTMGQYSN--PE------------GGMYLVESPDD 149 R +G ++ G A H E + T + P G + +S ++ Sbjct: 279 KAARRYGEQGYTIVIHGKAEHEETKATFSNSAKYAPSVVIRDIKEASILGEVIRAKSKEE 338 Query: 150 VWKL-------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVG------ 190 +L K+ ++L+ + QTTL ++T +I L + + G Sbjct: 339 KQRLFEPFVSRASVGFDPSKDLDRLALVNQTTLLRNETLKIIAYLEETLAETYGEAHVKE 398 Query: 191 -----PRKDDICYATTNRQEAV-RALAEQAEVVLVVGSKNSSNSNRLAELAQ-RMGKRAF 243 + D +CYAT Q+A+ +AL E + +VVG KNSSN+ +L L Q R G+RAF Sbjct: 399 HLAMSSKGDTLCYATQVNQDALAKALDEDIDAAIVVGGKNSSNTFQLFRLCQERFGERAF 458 Query: 244 LIDD-----AKDIQEEWV---------------------KEVKCVGVTAGASAPDILVQN 277 I ++D E ++ KE V VT GAS PD ++Q Sbjct: 459 YIQSEANILSRDEIEHFIFPYNPGDPKQGVMETRAFLPEKERVKVLVTGGASCPDGILQQ 518 Query: 278 VVARLQQLGGGEAI 291 ++ R+ E I Sbjct: 519 IICRINGFHAPERI 532 >UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MT01_9CHLO Length = 523 Score = 97.4 bits (241), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 93/333 (27%), Positives = 148/333 (44%), Gaps = 56/333 (16%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA+ GFC GV+RA+ + A Y A +++ +E++HN V L + G FIE+ Sbjct: 174 LKLADAYGFCWGVERAVQMAYEARKQYPDAKLWITNEIIHNPTVNKRLGDMGVNFIEETK 233 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S V +G ++I A G S + ++ D TCP V+KV V +R+ Sbjct: 234 DGKDFSGVGNGEVVILPAFGASVHEMKLLAEKGASIVDTTCPWVSKVWNAVDAHTRKEFT 293 Query: 116 SILIGHAGHPEVEGT---MGQY---SNPEGGMYLVE---SPDDVWKLTVK---------- 156 SI+ G H E T G Y + + YL + + D + K Sbjct: 294 SIIHGKWAHEETVATASFAGTYLVIKDMKEATYLCDYILNGGDKEEFMAKFVNAHSEGFD 353 Query: 157 ---NEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQE 205 + + L QTT+ +T + L + + G D IC AT RQ+ Sbjct: 354 PDVDLDGLGIANQTTMLKGETQAIGKLLERTMMEKHGVANLADHYMVMDTICDATQERQD 413 Query: 206 AVRALAE-QAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQE----------- 253 A+ L E + +++LVVG NSSN+ L E+++ +F +D + + E Sbjct: 414 AMYQLVEDKPDMMLVVGGYNSSNTQHLQEISEDASVPSFWVDTPERLDEDNVIAHRLAHG 473 Query: 254 ------EWVKEVKCV-GVTAGASAPDILVQNVV 279 +W+ E V GVT+GAS PD +V++VV Sbjct: 474 ELVETKDWLPEGDVVIGVTSGASTPDKVVEDVV 506 >UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Treponema RepID=ISPH_TREPS Length = 376 Score = 96.3 bits (238), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/315 (27%), Positives = 134/315 (42%), Gaps = 47/315 (14%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS- 61 I A+ G+C GV A+ + E+A A + +Y +VHN + LR RG ++ Sbjct: 10 ITRAHTLGYCGGVRMAVRMAEHARAHHRGSVYTLGPLVHNPVTLARLRARGIECLDPAHL 69 Query: 62 -----------------EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHM 104 E ++ AHGV+ V + V DATCP V + Sbjct: 70 SFALHAPAAPGAAPHAVEEKTARTVVIRAHGVAPEVYEALERSGAQVVDATCPRVKESQR 129 Query: 105 EVARASRRGEESILIGHAGHPEVEGTMG--------QYSNPEGGMYLVESPD----DVWK 152 + +G IL G H E+ G G S+ GG +PD V Sbjct: 130 RAQGFAAQGLHVILAGDRNHGEIVGIEGYVRAGAAQACSHLPGG-----APDGMLPQVQC 184 Query: 153 LTVKNEE---------KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNR 203 V+N + + + QTT++ + + A R R ++ R IC AT R Sbjct: 185 FVVQNAREAAALPCLARAALLAQTTITQGEYDAIAAAARTRVRELTVAR--TICAATARR 242 Query: 204 QEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVG 263 Q A+RALA E +LV+G +S+N+ RL A+ +L++ +DI + + VG Sbjct: 243 QAALRALAPTVEALLVIGGAHSANTQRLLHTARETSLPTWLVERVEDIPPD-IYAFSAVG 301 Query: 264 VTAGASAPDILVQNV 278 ++AGAS PD ++ V Sbjct: 302 ISAGASTPDCVIAAV 316 >UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=115 Tax=cellular organisms RepID=ISPH_SYNR3 Length = 406 Score = 95.9 bits (237), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 93/344 (27%), Positives = 144/344 (41%), Gaps = 66/344 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFI---- 57 I LA GFC GV+RA++I Y I++ +E++HN V L E +FI Sbjct: 57 IRLAEAFGFCWGVERAVAIAYETRRHYPTERIWITNEIIHNPSVNAHLVEMNVLFIPVEE 116 Query: 58 --EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + S V G ++I A G + R + D TCP V+KV V R + Sbjct: 117 GVKDFSGVESGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWNSVERHKKNSFT 176 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLV----ESPDDVWKLTVKNEEKLSFM------- 164 S++ G H E T + G YLV E V + N + +F+ Sbjct: 177 SVIHGKVKHEETLAT-----SSFAGTYLVVLDLEEAQLVCDYILGNGNREAFLKRFAGAT 231 Query: 165 ----------------TQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYAT 200 QTT+ +T D+ + + GP + IC AT Sbjct: 232 SPGFDPDRDLSRIGVANQTTMLKSETEDIGRLFERTLLRRYGPTDLNDHFLAFNTICDAT 291 Query: 201 TNRQEAVRALAEQA-EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ------- 252 RQ+A+ +L ++ ++++V+G NSSN+ L E+A G + ID + I Sbjct: 292 QERQDAMFSLVDEPLDLMVVIGGYNSSNTTHLQEIAVSRGIPSVHIDAPERIGPGNAVEH 351 Query: 253 ----------EEWVKEVKC-VGVTAGASAPDILVQNVVARLQQL 285 E ++ E +G+T+GAS PD +V+ V+ RL QL Sbjct: 352 KPLGQDLERLEPFLPEGDLRIGITSGASTPDRVVEGVIDRLLQL 395 >UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Chlamydomonas reinhardtii RepID=A8JEV9_CHLRE Length = 465 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 90/347 (25%), Positives = 146/347 (42%), Gaps = 69/347 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENA-LAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA G+C GV+RA+ + A LA ++V +E++HN V L+E +E Sbjct: 101 VKLAKAYGYCWGVERAVRMAYEARLAHPDKKVFVTNEIIHNPEVNSRLKEMNIEIVEDEG 160 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + G ++IF A G + + K + + + D TCP V KV V +R+ Sbjct: 161 KGKDYSMIGGGDVVIFPAFGATVQELTDFKEKGVQMVDTTCPWVAKVWNSVDTHTRKQYT 220 Query: 116 SILIGHAGHPEVEGTMGQYSNP------EGGMYLVESPDDVWKLTVKNEE---------- 159 S++ G H E T SN + Y+ + + L N E Sbjct: 221 SVIHGKYSHEETIATASFASNYIIVKDLKEAQYVCD-----YILQGGNREEFLQKFSKAV 275 Query: 160 -----------KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYAT 200 ++ QTT+ +T + L K GP K + IC AT Sbjct: 276 SAGFDPETMLDRVGLANQTTMLKGETEQIGKMLEKTMLTKYGPAKLNDHFLLMETICDAT 335 Query: 201 TNRQEAVRALAEQAEV--VLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEE---- 254 RQ+A+ + E+ ++VVG NSSN++ L E+A+ G +F +D A I E Sbjct: 336 QERQDALYEMVADPEIDMMIVVGGFNSSNTSHLQEIAEHKGLASFWVDSAARIDVEKNVI 395 Query: 255 --------------WVKEVK--CVGVTAGASAPDILVQNVVARLQQL 285 W+ K +G+T+GAS PD V+ V+ ++ ++ Sbjct: 396 LHKLAHGELKETTGWLNPGKPVTIGITSGASTPDRAVEEVLHKVFKI 442 >UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Chlorobiaceae RepID=ISPH_CHLP8 Length = 332 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 86/326 (26%), Positives = 135/326 (41%), Gaps = 54/326 (16%) Query: 10 GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG--AIFIEQISEVPDGA 67 GFC GV I + E L G +Y +VVHN V L G I I E+ D Sbjct: 11 GFCIGVQGTIHVAEEKLNQSGE-LYCLGDVVHNEVEVKRLEALGMETIDIPAFEELRDAE 69 Query: 68 ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEV 127 +LI AHG + A+ +L + D TCP+V K+ + G + I+ G HPEV Sbjct: 70 VLI-RAHGEPPSTYETARRNNLAITDTTCPVVAKLQKTAKMLHQLGYQVIIYGKKIHPEV 128 Query: 128 EGTMGQYSNPEGGMYLVESPD-----DVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 G GQ N EG +++ PD ++ L + K + ++QTT+ V ++ L Sbjct: 129 IGINGQ-CNDEG--VVIKHPDLSDEAEIAPLDLG--RKTALISQTTMDVPGFYELKKNLE 183 Query: 183 KRF---------------------------------PKIVGPRKDDICYATTNRQEAVRA 209 K F P++V KD IC ++R +R Sbjct: 184 KLFAEHGHRNPGTKSGEWMAVRDIDITSEKTGGRAMPELV--YKDTICRQVSSRNGKLRD 241 Query: 210 LAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWV-----KEVKCVGV 264 A + ++ + SSN L + + ++ I+D +IQ EW K V+ VG+ Sbjct: 242 FALANDCIVFAAGRKSSNGQVLYSICKDANPHSYFIEDVDEIQPEWFVGENGKPVESVGI 301 Query: 265 TAGASAPDILVQNVVARLQQLGGGEA 290 S P L++ V + + G ++ Sbjct: 302 CGATSTPMWLLEKVANYIGKTFGDDS 327 >UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Prevotella RepID=C5VII4_9BACT Length = 335 Score = 94.7 bits (234), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/330 (24%), Positives = 132/330 (40%), Gaps = 61/330 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 +QI + N GFC GV AI E LA G +Y ++VHN V+ L ++G I I E Sbjct: 2 LQIEIDNGSGFCFGVTTAIKKAEEELA-KGTKLYCLGDIVHNSMEVERLTKKGLITINHE 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES-- 116 Q+ E+ + +L+ AHG A+ ++ + DATCP+V + + +G + Sbjct: 61 QMRELHNVKVLL-RAHGEPPETYELARRNNIEIIDATCPVVLALQRRIKTQYEKGRQPSY 119 Query: 117 -------------------------------------------------ILIGHAGHPEV 127 ++ G GH EV Sbjct: 120 MISSKGGAAVDEPSSLKPVTNEAVETSISSVSLPPAVGEGQELSASSSIVIFGKNGHAEV 179 Query: 128 EGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRF-P 186 G +GQ ++E +DV L N+ + +QTT S+D+ +I+ ++ P Sbjct: 180 LGLVGQ---THSQAIVIEKFEDVKALDFNND--IYLYSQTTKSLDEFHKIIEYIQSHISP 234 Query: 187 KIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLID 246 K D IC NR + A + +++L V + SSN L + + ++ Sbjct: 235 KAKFQSFDTICRQVANRMPNISTFAARHDLILFVAGRKSSNGKVLFHECLSVNPNSHQVE 294 Query: 247 DAKDIQEEWVKEVKCVGVTAGASAPDILVQ 276 A +I W V+ VG+ S P L++ Sbjct: 295 SADEIDMSWFDGVETVGICGATSTPKWLME 324 >UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V303_9AQUI Length = 167 Score = 92.4 bits (228), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 50/167 (29%), Positives = 99/167 (59%), Gaps = 3/167 (1%) Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G GHPEV GT+G G +V + +++ K + K+ + QTT S D + + Sbjct: 1 MGEHGHPEVIGTLGHLEESGGRGIVVSNMEELVK-NLPRTSKVGVVAQTTQSEDFFREAV 59 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + ++ + IC AT+ RQE V+ +A +V++++G K+S N+NRLA++++ + Sbjct: 60 GYIAENIEEV--KIFNTICDATSVRQEEVKKIAPNVDVMIIIGGKHSGNTNRLAQISRYL 117 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ A +I+ +W++ + +G++AGAS PD ++ VV ++++L Sbjct: 118 NPDTYHIEKADEIEPKWLEGKEKIGISAGASTPDWIINEVVEKVKKL 164 >UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH n=5 Tax=Verrucomicrobia RepID=B3DZ81_METI4 Length = 419 Score = 90.1 bits (222), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 96/357 (26%), Positives = 147/357 (41%), Gaps = 77/357 (21%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFIEQ 59 + + LA GFC GV+RAI + ++ I++ E++HN V D L G I++ Sbjct: 51 ITVKLAKAFGFCYGVERAIDLAYATTKVFPTKRIFLLGEIIHNPEVNDQLTAMG---IKR 107 Query: 60 ISEVPDGAIL---------IFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 + V G L I A G + + D TC V V V + Sbjct: 108 LQAVEGGYFLDGLTADDVVIIPAFGAEVETMKRIQQIGCQIVDTTCGDVMTVWKRVRQYR 167 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEG-GMYLV----ESPDDVWKLTVKNEEKLSFM- 164 + G SI+ G A H E + T + +G G YLV E D V +K F+ Sbjct: 168 KEGATSIIHGKAWHEETKATASRAIGEDGNGHYLVVYNLEETDYVCNYIRYGGDKKEFLE 227 Query: 165 ----------------------TQTTLSVDDTSDVIDALRKRFPKIVGPRK--------- 193 QTT+ +T +V ++R K + R Sbjct: 228 KFKGAVSPGFDPDVHLCHVGVANQTTMMRGETEEV----QRRICKAIEDRYGKENLHEHF 283 Query: 194 ---DDICYATTNRQEAVRAL--AEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDA 248 D IC AT RQ+A+ + E+ ++++VVG NSSN++ LAE+ + F+ + Sbjct: 284 RFFDTICGATQERQDALLDMLDKEKLDLLIVVGGYNSSNTSHLAEIGESRLPTYFIKNAE 343 Query: 249 KDIQ-----------------EEWVKEVKC-VGVTAGASAPDILVQNVVARLQQLGG 287 K I E W+KE + VG+TAGAS P+ L++ + RL +L G Sbjct: 344 KLISTRQIQHWDLHKGQEVITEGWLKEGEINVGITAGASCPNNLIEETIQRLFELRG 400 >UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Sphingobacteriales RepID=Q2S1D9_SALRD Length = 413 Score = 89.7 bits (221), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 90/345 (26%), Positives = 151/345 (43%), Gaps = 68/345 (19%) Query: 5 LANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI-----E 58 +A GFC GV++AI I AL I++ E++HN +V + LR+RG F+ E Sbjct: 46 IARHFGFCFGVEQAIEIAYEALEENPDKRIFLLSEMIHNPHVNEDLRDRGIQFLRTTQGE 105 Query: 59 QI---SEVPDGAILIFSAHGVSQAVRN--EAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 Q+ E+ ++I A G + V E D +D TCP V KV + ++ Sbjct: 106 QLIPFDELTPDDVVIIPAFGTTLEVEQKLEEIGVDTEAYDTTCPFVEKVWRKSSQIGDDD 165 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTV------------------ 155 ++ G H E T ++ EG + +V ++ +L Sbjct: 166 HSIVVHGKRYHEETRATFS-HAKEEGPVVVVRDMEEAEELAKVIRGEKDADFFYDYFEDK 224 Query: 156 --------KNEEKLSFMTQTTLSVDDTSDVID----ALRKRFPKI-----VGPRKDDICY 198 ++ +KL + QTT+ ++T+ + D A+R+R+ + D +CY Sbjct: 225 YSEDFDPERDLQKLGVVNQTTMLAEETAAIADLMRDAMRERYGEAHVEERFADTSDTLCY 284 Query: 199 ATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK-------- 249 AT Q A +AL E A++ +VVG NSSN++ L EL + F+ D ++ Sbjct: 285 ATNENQNATQALIEDGADLGIVVGGYNSSNTSHLVELCEEHMPTYFIRDASEFDAPSEIH 344 Query: 250 --DIQ-------EEWVKEVKC---VGVTAGASAPDILVQNVVARL 282 D+ ++W V +T+GAS PD L+ VV ++ Sbjct: 345 HFDVHAKEEVATDDWFPAEDTPVDVLLTSGASCPDALLDEVVRKI 389 >UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q0DNV6_ORYSJ Length = 482 Score = 88.6 bits (218), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 89/362 (24%), Positives = 160/362 (44%), Gaps = 83/362 (22%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI-- 57 ++++LA GFC GVD A+ + +A + +++ ++++HN V + L E G I Sbjct: 123 VRLILAEAHGFCLGVDNAVRLAYDARVKFPDRRLWLTNQIIHNPTVSERLDEMGIKIIPV 182 Query: 58 ----EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 + +S V DG ++IF A G + +++ + D TCPLV KV R + Sbjct: 183 VSGVKDLSVVEDGDVVIFPAFGFTVDEMVTLNRKNVHIVDTTCPLVLKVVHMTERHIKGN 242 Query: 114 EESILIGHAGHPE---------------------------VEGTM-GQYSNPEGGM---- 141 +I+ G H E +EG + G S E + Sbjct: 243 YTTIIHGKYAHEETVATASFADKYIIVKDITEAKYVCDYILEGQLDGSSSTKEKFLKKFR 302 Query: 142 YLVE---SPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDD--- 195 Y V PD + E++ + QTT+ +T ++ + + G +++ Sbjct: 303 YAVSPGFDPD-------IDLERVGVVNQTTMLKGETKEIGILIEQTMMSKYGLDQNNKQE 355 Query: 196 -------ICYATTNRQEAVRALAE-QAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDD 247 IC AT RQ+A+ L E + +++LVVG NSSN++ L E+ + G ++ +D Sbjct: 356 HFVRVGTICNATQERQDAMYKLVEKEVDLILVVGGWNSSNTSHLQEIGELSGIPSYWVDG 415 Query: 248 AKDI-----------------QEEWVKE-VKCVGVTAGASAPDILVQNVVARL-----QQ 284 + I +++W+ +GVT+GAS PD +V++V+ ++ Q+ Sbjct: 416 EQRIGPGNKISYKQKNGELVEKDKWLPHGAITIGVTSGASTPDKVVEDVLQKVFEIKRQE 475 Query: 285 LG 286 LG Sbjct: 476 LG 477 >UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP Length = 306 Score = 87.8 bits (216), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 105/226 (46%), Gaps = 14/226 (6%) Query: 10 GFCAGVDRAISIVENAL-AIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQISEVPDG 66 GFC GV +A+S E L +G P+Y ++VHNR VD L G I EQ S + + Sbjct: 17 GFCFGVIKAVSRAEEILRQEHGEPLYCLGDIVHNRAQVDRLESLGMRTIDHEQFSHLSNA 76 Query: 67 AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA----SRRGEESILIGHA 122 +L + AHG A A + V DATCP+V ++ +V +A + + ++ G Sbjct: 77 RVL-YRAHGEPPASYTYAAENGIEVVDATCPVVLRLQQKVRQAYLQHANDDTQIVIFGKP 135 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 GH EV G +GQ +G +V P D+ V + +QTT+ D +++ ++ Sbjct: 136 GHAEVNGLVGQ---TDGKAIVVREPKDLD--LVDFARSIELFSQTTMQEDQLEEMLSLIQ 190 Query: 183 KRFPKIVG-PRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSN 227 R + IC + R +R A+ + + V + SSN Sbjct: 191 SRLSDTATLVSHNTICQQVSRRIPNIREFAKSHDRIFFVSDQKSSN 236 >UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=Q1ATX3_RUBXD Length = 410 Score = 87.8 bits (216), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 95/356 (26%), Positives = 149/356 (41%), Gaps = 69/356 (19%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI-- 57 + + LA+ GFC GVDRA+ + I++ +++HN + LRE G F+ Sbjct: 45 LTLRLADEFGFCYGVDRAVDYAFQTREKFPDRRIFLTGDMIHNASMNARLREMGIEFLSQ 104 Query: 58 -------EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 E+ ++ + ++I A G + + R + D TC V V VAR + Sbjct: 105 GFDGRPDERFEDLDEEDVVILPAFGAPVEWVGKLRERGCIIVDTTCGSVLSVWKRVARYA 164 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEG-GMYLVES--------PDDVWKLTVKNEEK- 160 ++G SI+ G H E T Q G G YL+ D + T E K Sbjct: 165 QKGFTSIIHGKYYHEETRATASQTRREGGNGKYLIVRDLKETGYLTDFIRGRTSAGELKE 224 Query: 161 ------------------LSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------D 194 + QTT+ + +T V + +RK + G D Sbjct: 225 RLGHGMSPGFDPERDLVRVGVANQTTMLMTETMKVGEEIRKAMEERYGRENLAEHFELFD 284 Query: 195 DICYATTNRQEAV-RALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLI-------- 245 IC AT +RQ+A+ R L +VV++VG NSSN+N LA +A R++ I Sbjct: 285 TICSATQDRQDALMRLLEHPLDVVVIVGGYNSSNTNNLAIIAAGRVPRSYHIANGECIRG 344 Query: 246 ------------DDAKDIQEE-WVKEVKC-VGVTAGASAPDILVQNVVARLQQLGG 287 D ++++EE W+ E VG+TAGAS P+ + V R+ + G Sbjct: 345 ASIRHKPPGTPLDPREEVEEEGWLPEGPVRVGLTAGASTPNSQIGLAVRRILEARG 400 >UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Cyanobacteria RepID=ISPH_ACAM1 Length = 415 Score = 83.2 bits (204), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 89/358 (24%), Positives = 147/358 (41%), Gaps = 75/358 (20%) Query: 3 ILLANPRGFCAGVDRAISIV-ENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I LA GFC GV+RAI++ E I++ +E++HN V +LR+ + +E I Sbjct: 57 IHLAEAFGFCWGVERAIALAYETRRQFPQERIWITNEIIHNPSVNKNLRD---MKVEFIP 113 Query: 62 EVPDGA----------ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 PDG ++I A G S + T+ D TCP V+KV V + + Sbjct: 114 VQPDGQKDFTVVGQNDVVILPAFGASVQEMQLLHDKGCTIMDTTCPWVSKVWTSVEKHKK 173 Query: 112 RGEESILIGHAGHPEVEGT---MGQY---SNPEGGMYLVE---SPDDVWKLTVKNEEKLS 162 SI+ G H E T G Y N E Y+ + +P D + + + + Sbjct: 174 GSYTSIIHGKYKHEETIATSSFAGTYLVLLNLEEAEYVADYILNPGDT--PSEREQRRAD 231 Query: 163 FM-----------------------TQTTLSVDDTSDVIDALRKRFPKIVGPRK------ 193 FM QTT+ +T + + + GP + Sbjct: 232 FMAKFANAHSPGFDPETDLERVGIANQTTMLKGETEQIGKLFERTVMRKYGPAQVNEHFL 291 Query: 194 --DDICYATTNRQEAVRALAEQA-EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD 250 + IC AT RQ+A+ L ++ ++++V+G NSSN+ L E++ ++ ID Sbjct: 292 SFNTICDATQERQDAIFQLVDEPLDLMVVIGGFNSSNTTHLQEISIDKNIPSYHIDSVDR 351 Query: 251 I-----------------QEEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEA 290 I + W+ +GVT+GAS PD +V ++V ++ + A Sbjct: 352 IGPGNRVEHKPLNADLTVTDNWLPNGPLAIGVTSGASTPDKVVSDIVEKIFSIKSASA 409 >UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Perkinsus RepID=B1Q2Q7_9ALVE Length = 575 Score = 81.3 bits (199), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 98/385 (25%), Positives = 153/385 (39%), Gaps = 107/385 (27%) Query: 5 LANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI------ 57 LA GFC GV+RA++I + Y I++ +EV+HN V +L E G +I Sbjct: 178 LAEAHGFCWGVERAVAIAYESSRRYPDKTIWMTNEVIHNPTVNRNLEELGIRYIPRDAGN 237 Query: 58 -EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + S V G ++I A G + E K + +T+ D TCP V+KV V R + S Sbjct: 238 QKDFSVVSAGDVVILPAFGAAVKEMMELKRKGVTIVDTTCPWVSKVWSSVERHKKGEYTS 297 Query: 117 ILIGHAGHPEVEGTMG---QY---SNPEGGMYLVES---------PDDVWKL-------- 153 I+ G + H E T +Y N + Y+ + DD ++ Sbjct: 298 IIHGKSKHEETIATSSFADKYLILKNLKDAEYVCKFLLSKNKERLVDDFFEKFPADRHSV 357 Query: 154 ---TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTN 202 +K+ EK+ QTT+ +T+ + K ++ GP + IC AT + Sbjct: 358 GFDPLKDLEKVGVANQTTMLKGETALIAKLFEKTILQLYGPEGLNEHFVAFNTICDATQD 417 Query: 203 RQEAVRAL-------------------------------AEQAEVVLVVGSKNSSNSNRL 231 RQ+A+ L A + +++LVVG NSSN+ L Sbjct: 418 RQDALYKLVGEKYEQPQSDMLEELGVDTPKTTDPQVTPTATKLDMMLVVGGFNSSNTEHL 477 Query: 232 AELAQRMG----KRAFLIDDAKDIQE---------------EWVK--------------- 257 E++ G RAF ID I E E + Sbjct: 478 QEISVEAGGVKDHRAFHIDGPARIDELRNTITHKPVETPPIEAARNHGLAVTHDFLPGDG 537 Query: 258 EVKCVGVTAGASAPDILVQNVVARL 282 E +GVT+GAS PD +++ + +L Sbjct: 538 EHITIGVTSGASTPDDVLEQSLQKL 562 >UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AAK2_GEMAT Length = 437 Score = 73.6 bits (179), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 91/362 (25%), Positives = 141/362 (38%), Gaps = 75/362 (20%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I LA GFC GV+RA+ + I++ E++HN +V L+E G IF+ Sbjct: 73 IRLAREFGFCYGVERAVDYAYQTRRKFPERRIFLAGEIIHNPHVNAKLQEMGVIFLSAKG 132 Query: 62 EVPDGA------ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + D A ++I A GV+ + V D TC V V V +R G Sbjct: 133 KGFDYAPVEPKDVVILPAFGVTIQDFQTLRELGCVVVDTTCGSVLNVWKRVEAYARDGFT 192 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLV------------------------------- 144 S++ G H E T Q GG YLV Sbjct: 193 SLIHGKYYHEETRATASQVEKYNGGQYLVVRDMAEAELVMDYLEDRAGVQPAREPLSREA 252 Query: 145 ------ESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK----- 193 ++ D + V + E++ QTT+ ++ + A+ + + G Sbjct: 253 FLERFAKAASDGFDPDV-HLERVGVANQTTMLARESLAIGAAVGESMTRGYGEAHRAEHF 311 Query: 194 ---DDICYATTNRQEAV-RALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLID-DA 248 D IC AT +RQ+AV L + ++++VVG NSSN+ LA L + D D Sbjct: 312 RTFDTICSATQDRQDAVMELLRDPLDLMVVVGGYNSSNTISLAALCAEQVPTYHIADPDE 371 Query: 249 KDIQEEWVKEVKC--------------------VGVTAGASAPDILVQNVVARLQQLGGG 288 D+ E V+ + +G+TAGAS P+ + VAR+ + G Sbjct: 372 IDVAENRVRYRRIGAKHHEDEMSSWLPTTGPLRIGITAGASTPNNKIGQAVARVFAIRGV 431 Query: 289 EA 290 +A Sbjct: 432 DA 433 >UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KX15_9GAMM Length = 66 Score = 66.6 bits (161), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 33/60 (55%), Positives = 39/60 (65%) Query: 251 IQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRV 310 I+E W+ VGVTAGASAP+ LVQ+VV LQ G E PL G ENI F +PK LR+ Sbjct: 2 IEEGWLTPESVVGVTAGASAPEALVQDVVTALQARGADEVTPLNGEPENITFSLPKGLRI 61 >UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5KI36_9ALVE Length = 429 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 77/174 (44%), Gaps = 46/174 (26%) Query: 155 VKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEA 206 +K+ EK+ QTT+ +T+ + K ++ GP + IC AT +RQ+A Sbjct: 243 LKDLEKVGVANQTTMLKGETALIAKLFEKTVLQLYGPEGLNEHFVAFNTICDATQDRQDA 302 Query: 207 VRAL----AEQAEVVLVVGSKNSSNSNRLAELAQRMG----KRAFLIDDAKDIQE----- 253 + L A + +++LVVG NSSN+ L E++ G RAF ID I E Sbjct: 303 LYKLVTPTATKLDMMLVVGGFNSSNTEHLQEISVEAGGVKDHRAFHIDGPARIDELRNTI 362 Query: 254 ----------------------EWVK---EVKCVGVTAGASAPDILVQNVVARL 282 +++ E +GVT+GAS PD +++ + +L Sbjct: 363 THKPVETPPIEAARNHGLAVTHDFLPGNGEHITIGVTSGASTPDDVLEQSLQKL 416 >UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CI73_9FIRM Length = 83 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/78 (35%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIF---I 57 M + +A GFC GV RA+ V + PIY ++HN VV L +G I Sbjct: 1 MNVKVAEHAGFCFGVRRAVDKVYELIESQEKPIYTLGPIIHNESVVGDLEAKGVKVIENI 60 Query: 58 EQISEVPDGAILIFSAHG 75 EQ+ V DG ++I S+ G Sbjct: 61 EQLHSVRDGVVVIRSSRG 78 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 444 e-123 UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 433 e-120 UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 416 e-115 UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 415 e-115 UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2... 406 e-112 UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 400 e-110 UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 399 e-110 UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5... 396 e-109 UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 396 e-109 UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C... 392 e-107 UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 390 e-107 UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 389 e-107 UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium... 387 e-106 UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 385 e-105 UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 382 e-105 UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 379 e-104 UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 378 e-103 UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 375 e-103 UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 375 e-102 UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organis... 370 e-101 UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7... 370 e-101 UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepI... 367 e-100 UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4... 365 e-100 UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_P... 364 3e-99 UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 362 8e-99 UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 362 1e-98 UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 362 1e-98 UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 361 2e-98 UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 361 2e-98 UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 360 2e-98 UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 360 4e-98 UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 359 7e-98 UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 358 1e-97 UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 358 2e-97 UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candida... 357 3e-97 UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 357 4e-97 UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 354 2e-96 UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 354 3e-96 UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2... 353 5e-96 UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 353 5e-96 UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostri... 351 2e-95 UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 348 1e-94 UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 347 2e-94 UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 347 3e-94 UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 347 4e-94 UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 346 6e-94 UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 344 2e-93 UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2... 344 2e-93 UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 344 3e-93 UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 343 4e-93 UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=5... 342 1e-92 UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 341 2e-92 UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 340 3e-92 UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 340 4e-92 UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 337 3e-91 UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 336 5e-91 UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1... 334 3e-90 UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 334 3e-90 UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3... 333 5e-90 UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 332 1e-89 UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1... 331 2e-89 UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 331 2e-89 UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 330 6e-89 UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 329 9e-89 UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2... 328 1e-88 UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collins... 328 1e-88 UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 328 2e-88 UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 328 2e-88 UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 327 4e-88 UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/rib... 325 1e-87 UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 325 2e-87 UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 325 2e-87 UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 322 1e-86 UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 322 1e-86 UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 322 1e-86 UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 320 4e-86 UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 318 1e-85 UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerof... 318 1e-85 UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1... 317 3e-85 UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 317 3e-85 UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 316 7e-85 UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 315 2e-84 UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 315 2e-84 UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 313 4e-84 UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 313 5e-84 UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8... 312 9e-84 UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 312 1e-83 UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 311 2e-83 UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 310 4e-83 UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 308 1e-82 UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 308 2e-82 UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 307 2e-82 UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 307 4e-82 UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 306 6e-82 UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 303 5e-81 UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 303 5e-81 UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipe... 300 5e-80 UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 298 1e-79 UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate ... 298 2e-79 UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 297 3e-79 UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 296 6e-79 UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 296 7e-79 UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteri... 295 1e-78 UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 295 2e-78 UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCM... 293 5e-78 UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 293 7e-78 UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 292 9e-78 UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 289 9e-77 UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 288 1e-76 UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 286 7e-76 UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 283 4e-75 UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 283 5e-75 UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 283 7e-75 UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellu... 281 2e-74 UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 281 3e-74 UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 281 3e-74 UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 3e-74 UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 3e-74 UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 4e-74 UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 4e-74 UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax... 278 2e-73 UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudona... 278 2e-73 UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 278 2e-73 UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 T... 277 3e-73 UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 276 5e-73 UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 275 2e-72 UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2... 274 3e-72 UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 274 3e-72 UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 274 3e-72 UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q... 273 8e-72 UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 271 2e-71 UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reducta... 270 4e-71 UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 269 9e-71 UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 267 4e-70 UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphat... 265 2e-69 UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 261 3e-68 UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 260 5e-68 UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 260 6e-68 UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 258 2e-67 UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 251 2e-65 UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP 250 4e-65 UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 239 6e-62 UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyt... 237 4e-61 UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 223 9e-57 UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphospha... 219 8e-56 UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 219 8e-56 UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1... 204 2e-51 UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 200 4e-50 UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate ... 188 2e-46 UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 156 8e-37 UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammapr... 132 2e-29 UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate ... 111 3e-23 UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia... 103 1e-20 UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 80 1e-13 Sequences not found previously or not previously below threshold: UniRef50_Q6LH35 Putative uncharacterized protein n=1 Tax=Photoba... 76 2e-12 UniRef50_Q075K0 Plastid lyt B-like protein (4-hydroxy-3-methylbu... 69 2e-10 UniRef50_Q7MUK6 LytB-related protein n=2 Tax=Bacteria RepID=Q7MU... 63 1e-08 UniRef50_D2MHW9 Putative uncharacterized protein (Fragment) n=1 ... 59 2e-07 UniRef50_Q4E9V2 Hydroxymethylbutenyl pyrophosphate reductase (Fr... 53 1e-05 UniRef50_Q5YBC4 Plastid ispH (Fragment) n=1 Tax=Helicosporidium ... 51 7e-05 UniRef50_C5IH56 At4g34350-like protein (Fragment) n=3 Tax=Solanu... 49 2e-04 UniRef50_C5WLY1 Putative uncharacterized protein Sb01g009135 (Fr... 45 0.003 UniRef50_Q88MU9 Thiol:disulfide interchange protein DsbC n=21 Ta... 44 0.006 >UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=23 Tax=Proteobacteria RepID=ISPH_MARAV Length = 316 Score = 444 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 213/316 (67%), Positives = 255/316 (80%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI IV AL ++GAPIYVRHEVVHN++VVD+LR RGAIF++++ Sbjct: 1 MQIRLANPRGFCAGVDRAIEIVNRALDVFGAPIYVRHEVVHNKFVVDNLRNRGAIFVDEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPD ++IFSAHGVSQAV+NEA R L VFDATCPLVTKVHMEV R SR G E ILIG Sbjct: 61 GEVPDDKLVIFSAHGVSQAVQNEAARRGLKVFDATCPLVTKVHMEVMRYSRDGRECILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMGQY + GG +YLVE DV KL VK+ +LSF+TQTTLS+DDT+ VID Sbjct: 121 HHGHPEVEGTMGQYDHSNGGDIYLVEDEADVQKLEVKDPSRLSFVTQTTLSMDDTARVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALR +FP+I GPRKDDICYAT NRQ+AV+ LA +++LVVGS NSSNSNRL ELA+RMG Sbjct: 181 ALRAKFPQIEGPRKDDICYATQNRQDAVKQLAGDCDIMLVVGSPNSSNSNRLRELAERMG 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 A+LID+A I W+ K +GVTAGASAP++LV +V+ RL+ LGG E + + GREE+ Sbjct: 241 TPAYLIDEAAQIDPAWLYGKKAIGVTAGASAPEVLVADVIKRLKALGGEEPVEVSGREES 300 Query: 300 IVFEVPKELRVDIREV 315 IVF +PKELR+D E+ Sbjct: 301 IVFSMPKELRIDAVEL 316 >UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=187 Tax=Bacteria RepID=ISPH_PSYWF Length = 318 Score = 433 bits (1115), Expect = e-120, Method: Composition-based stats. Identities = 206/316 (65%), Positives = 260/316 (82%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI+IV ALA + PIYVRHEVVHN++VV L RGA+F+E++ Sbjct: 1 MQIYLANPRGFCAGVDRAIAIVNEALARFEPPIYVRHEVVHNKFVVSDLANRGAVFVEEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPDG+I+IFSAHGVS+AV +EA+ RDLTVFDATCPLVTKVH+EVA+ +R +++LIG Sbjct: 61 HEVPDGSIVIFSAHGVSKAVEDEAERRDLTVFDATCPLVTKVHIEVAKFAREKMDAVLIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMG++S GG ++LVE+ DV KL V + ++L+F+TQTTLS+DDT+ VID Sbjct: 121 HQGHPEVEGTMGRFSAQYGGEIHLVENEADVEKLEVSDPDRLAFVTQTTLSMDDTAVVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALRK+FP I GPRKDDICYAT NRQ+AV+ LA++ EVVLVVGS NSSNSNRL ELA+RM Sbjct: 181 ALRKKFPNIQGPRKDDICYATQNRQDAVKDLAQRCEVVLVVGSPNSSNSNRLRELAERMN 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 +A+LID+A ++++EW V VGVTAGASAP+IL+Q V+ +LQQ GG L+G EEN Sbjct: 241 CKAYLIDNAGEMKKEWFAGVGAVGVTAGASAPEILIQEVLNQLQQWGGDLPDELKGIEEN 300 Query: 300 IVFEVPKELRVDIREV 315 + F +PKELR+ ++EV Sbjct: 301 VTFSLPKELRIPVKEV 316 >UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Proteobacteria RepID=Q3JAD0_NITOC Length = 320 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 175/315 (55%), Positives = 233/315 (73%), Gaps = 4/315 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA PRGFCAGV RAI IVE+AL IYGAPIYV HE+VHN++VV+ L+ RG IF E + Sbjct: 1 MKVTLAQPRGFCAGVVRAIDIVEHALEIYGAPIYVLHEIVHNQHVVEDLQRRGVIFTEDL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + +P G++ IFSAHGVS AV AK DL V DATCPLVTKVH++ + R+G+E I+IG Sbjct: 61 ASIPAGSVTIFSAHGVSTAVVETAKKNDLQVIDATCPLVTKVHLQAKKYYRQGDELIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HAGHPEVEGT G+ +G +Y+++S +V L VK+ E ++++TQTTLS+DDT DV+DA Sbjct: 121 HAGHPEVEGTRGRV---KGTVYVLDSVAEVENLAVKDPEHIAYVTQTTLSIDDTRDVVDA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+KRFPKI GP DDICYAT NRQ AVR ++++ +++LVVG++NSSNSNRL E+ ++ G Sbjct: 178 LKKRFPKIHGPGLDDICYATQNRQNAVREMSKKVDILLVVGARNSSNSNRLREVGEQNGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A LI DAKD+ W VG+TAGAS P+ILVQ V+ L+ G E + L+G +E+I Sbjct: 238 TAHLIQDAKDLDSSWFTSQSRVGITAGASTPEILVQGVLNELRSYGVEEVMDLDGVQESI 297 Query: 301 VFEVPKEL-RVDIRE 314 F +P L R +R+ Sbjct: 298 SFRLPTMLPRAKLRQ 312 >UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=437 Tax=cellular organisms RepID=ISPH_POLSJ Length = 333 Score = 415 bits (1068), Expect = e-115, Method: Composition-based stats. Identities = 175/314 (55%), Positives = 240/314 (76%), Gaps = 3/314 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +ILLA PRGFCAGVDRAI IVE AL +GAPIYVRHE+VHN YVV+ L+ +GAIFIE++S Sbjct: 10 EILLAEPRGFCAGVDRAIEIVERALTKFGAPIYVRHEIVHNTYVVNELKAKGAIFIEELS 69 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP GA L+FSAHGVS+A+++EA++R +FDATCPLVTKVH+EVA+ + G E I+IGH Sbjct: 70 DVPPGATLVFSAHGVSKAIQDEARARGFQIFDATCPLVTKVHVEVAKLHKEGYEFIMIGH 129 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GHPEVEGTMGQ + G++LVE DV ++T E+L+ +TQTTLSVDD +++ A+ Sbjct: 130 KGHPEVEGTMGQL---DSGIHLVEDVADVARITPSQTERLAVVTQTTLSVDDAAEISAAV 186 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + RFP++ P++ DICYAT NRQ+AV+ L+ Q ++++VVGS SSNSNRL ELA ++G Sbjct: 187 KARFPQVREPKQQDICYATQNRQDAVKVLSPQVDILIVVGSPTSSNSNRLRELAAKLGTE 246 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 A+++DDA +++E W + VG+TAGASAP+ILV+ V+ R++ LG ++G EE I Sbjct: 247 AYMVDDASELRESWFEGKSRVGLTAGASAPEILVKQVIDRIRALGAVSVRKMDGIEETIK 306 Query: 302 FEVPKELRVDIREV 315 F +PK L+VD + Sbjct: 307 FPLPKGLKVDAQGH 320 >UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Actinomycetales RepID=D2PN99_9ACTO Length = 358 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 158/313 (50%), Positives = 220/313 (70%), Gaps = 4/313 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +YG P+YVR E+VHN++VV +L+ RGAIF+++ Sbjct: 36 RVLLAAPRGYCAGVDRAVVAVEKALDLYGPPVYVRKEIVHNKHVVQTLQARGAIFVDETD 95 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G +IFSAHGV+ V EA +R L DATCPLVTKVH E R + + +LIGH Sbjct: 96 EVPEGETVIFSAHGVAPVVHQEAAARQLKTIDATCPLVTKVHHEAKRFAATDYDILLIGH 155 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ ++LV+ P DV + V++ EK+ +++QTTLSVD+T + + L Sbjct: 156 EGHEEVIGTSGEAP---EHIHLVDGPGDVPNVEVRDPEKVVWLSQTTLSVDETMETVRRL 212 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP + P DDICYAT NRQ AV+ LA A++++VVGS+NSSNS RL E+A G + Sbjct: 213 RERFPHLQDPPSDDICYATQNRQAAVKKLAADADLMIVVGSRNSSNSVRLVEVAVEHGAK 272 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+D A +I E W++ V VGVT+GAS P+ILV++V+ L G GE + EE++ Sbjct: 273 AGYLVDYADEIDEAWLEGVDSVGVTSGASVPEILVRDVLDWLAARGYGEVQEVTTAEESL 332 Query: 301 VFEVPKELRVDIR 313 F +P+ELR D++ Sbjct: 333 TFALPRELRTDLK 345 >UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Proteobacteria RepID=ISPH_WIGBR Length = 315 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 164/315 (52%), Positives = 238/315 (75%), Gaps = 2/315 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I LANPRGFCAGVDRAI+IV+NA+ IYG PIYV +EVVHN+YVV+SL++ G+IF+++I Sbjct: 1 MNIFLANPRGFCAGVDRAINIVKNAIEIYGPPIYVYNEVVHNKYVVNSLKKIGSIFVKKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP+ +ILIFSAHGVS+++ EA R L +FDATCPLV+KVH E+ RAS+ E I+IG Sbjct: 61 CDVPEKSILIFSAHGVSKSILKEANKRKLIIFDATCPLVSKVHHEIKRASKLRSEVIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+ GT+GQY+NP +++++S +++ KL +K+ L + TQTTLSVDDT+ +I A Sbjct: 121 HKNHPEIIGTIGQYNNPNKKVFVIQSIEEICKLKIKDPNNLFYFTQTTLSVDDTNKIIFA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++K++P I+ PRK DICYAT NRQ++++ + + +++ ++GSKNSSNSNRL E+A + GK Sbjct: 181 IKKKYPYIIEPRKKDICYATENRQKSIKKIIKLVDIIFIIGSKNSSNSNRLFEIANKSGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA--IPLEGREE 298 +++LID K+I++ W+ V +G+TAGASAP+ILVQ VV L+ ++G E Sbjct: 241 KSYLIDTYKEIKKSWLNGVNNIGITAGASAPEILVQQVVNYLKIFYKNSVNIYQVDGDIE 300 Query: 299 NIVFEVPKELRVDIR 313 F +PK+L + I+ Sbjct: 301 KTKFMIPKKLILKIK 315 >UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Bacteria RepID=ISPH_ACIC1 Length = 340 Score = 399 bits (1027), Expect = e-110, Method: Composition-based stats. Identities = 151/313 (48%), Positives = 219/313 (69%), Gaps = 4/313 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGV+RA+ VE AL +YG P+YVR ++VHN++VV L +GAIF+E+ Sbjct: 11 RVLLAQPRGYCAGVERAVDTVEKALELYGPPVYVRKQIVHNKHVVAELEAKGAIFVEEAD 70 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G+I++ SAHGV+ +V +A+ R L DATCPLVTKVH E R + +G E +LIGH Sbjct: 71 EVPEGSIVVLSAHGVAPSVYEQARQRRLKTIDATCPLVTKVHQEARRFAEQGLEILLIGH 130 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 A H EV GT G+ + LV+ P++ + VK+ ++++++QTTLSVD+T ++ L Sbjct: 131 ANHEEVVGTTGEAP---SSITLVDGPEEAEHVQVKDPSRVAWLSQTTLSVDETLQTVEVL 187 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP+++ P DDICYAT NRQ AV+ +A A++V+VVGS+NSSNS RL E+A G + Sbjct: 188 RRRFPQLIDPPSDDICYATQNRQAAVKRIAAIADLVIVVGSRNSSNSARLVEVALDSGAK 247 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+DDA +I E W+ V VGVT+GAS P+ LV V+A L + G ++ E + Sbjct: 248 ASYLVDDASEIDERWLDGVWTVGVTSGASVPESLVTGVLAWLAERGFDTVEEIDAERETL 307 Query: 301 VFEVPKELRVDIR 313 VF +P ELR +++ Sbjct: 308 VFALPPELRRELK 320 >UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5 Tax=Bacteria RepID=C9RIQ9_FIBSS Length = 310 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 219/309 (70%), Gaps = 3/309 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+LA PRGFCAGVDRAI +VE A+ +G PIYVRHE+VHN++VVD+L+++G +F++++ Sbjct: 3 KIVLATPRGFCAGVDRAIHVVEKAIEKFGTPIYVRHEIVHNKFVVDTLKDKGVVFVDELD 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+++IFSAHGV++ + EAK+R+L V DA+CPLV KVH R G ILIGH Sbjct: 63 QVPEGSVVIFSAHGVAEHIYEEAKARNLQVLDASCPLVLKVHFSAKRHYNAGRHIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EVEGT+GQ PEG + L+ + +D + V +++L+++TQTTLSV +T +I+AL Sbjct: 123 AGHAEVEGTLGQL--PEGAITLIRNENDAETVDVPADKELAYITQTTLSVAETRKIIEAL 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 ++RFP I+GP D+CYAT NRQ AV L + +++LVVG+KNSSNS+RL EL G Sbjct: 181 KRRFPNIIGPEAGDLCYATGNRQAAVLELCSEVDMLLVVGAKNSSNSSRLMELGLEQGLP 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ-LGGGEAIPLEGREENI 300 + LI D D+ W + + VG+++GASAP++LVQ VV L++ E L EN Sbjct: 241 SHLIADVNDLDPAWFEGIDTVGISSGASAPEVLVQGVVDWLKEKFAPVEVENLVKLVENT 300 Query: 301 VFEVPKELR 309 F +PK L+ Sbjct: 301 KFNLPKALQ 309 >UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=17 Tax=Rickettsiales RepID=ISPH_ANAMM Length = 342 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 155/307 (50%), Positives = 222/307 (72%), Gaps = 5/307 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG--APIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++++LA PRGFCAGV+RA+ +E+ + Y +Y HE+VHN +VV+S ++ G F+ Sbjct: 36 VEVILARPRGFCAGVERAVRTLESVASRYAGTREVYALHEIVHNLHVVNSFKKMGVKFVS 95 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + EVP+GA+L+FSAHGVSQ V+ E++ + LTV DATCPLVTKVH+E+ R + G + IL Sbjct: 96 ALHEVPEGAVLVFSAHGVSQQVKEESRRKGLTVVDATCPLVTKVHLEIQRYDKSGYQVIL 155 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +GH GH EVEG+MGQ SNP + LV++ DV + + + KL+++TQTTLS+DDT+++I Sbjct: 156 VGHKGHREVEGSMGQVSNP---VVLVQNVQDVQSIKIPSAAKLAYVTQTTLSMDDTAEII 212 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 AL+ RFP+IVGP DICYAT NRQ AV+A+++ +VVL +GSKNSSNSNRL +LA+ Sbjct: 213 SALKLRFPRIVGPDLRDICYATQNRQTAVKAMSQMVDVVLAIGSKNSSNSNRLLDLAKAQ 272 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 RA+LID ++I EW+ + +G+TAGASAP+ILVQ V+ L + ++G E Sbjct: 273 NARAYLIDSYRNIDLEWLIGARRIGITAGASAPEILVQEVIDYLGLHANLKVRTMDGVSE 332 Query: 299 NIVFEVP 305 NI F++P Sbjct: 333 NITFKLP 339 >UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C516_9PLAN Length = 310 Score = 392 bits (1008), Expect = e-107, Method: Composition-based stats. Identities = 149/309 (48%), Positives = 215/309 (69%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LANPRGFCAGV+ AI +E + I+G+ +YV HE+VHN+YVV+ +G F+E + Sbjct: 1 MKVILANPRGFCAGVNMAIECLEEVIRIFGSNVYVYHEIVHNKYVVNRFTNQGVTFVEAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEVP+ +IL+FSAHGVS +RN+A+ R++ DATCPLVTKVH E + + G ILIG Sbjct: 61 SEVPENSILVFSAHGVSPVIRNQARERNIRTIDATCPLVTKVHTEAIKYADAGYHIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ + L+E+P++V L +L+F+TQTTLSV++ VI + Sbjct: 121 HEGHDEVIGTMGEAP---ESITLIETPEEVAALEFPEGARLAFLTQTTLSVEEAGRVIRS 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L++++P I P K+DICYATTNRQEAV L + ++VLV+GS+NSSNS RL E+ + GK Sbjct: 178 LKEKYPAIESPPKEDICYATTNRQEAVSELVSRVDLVLVLGSQNSSNSKRLMEIGKTAGK 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 AFLID +++ EW + + + +TAGASAP+++VQ ++ L+ E R+E++ Sbjct: 238 PAFLIDGVEEVLPEWFDQAETILITAGASAPEVVVQELIQFLEDNYQAEVENAIVRKESV 297 Query: 301 VFEVPKELR 309 F +PKELR Sbjct: 298 RFPLPKELR 306 >UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=210 Tax=cellular organisms RepID=ISPH_MYCVP Length = 337 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 164/309 (53%), Positives = 218/309 (70%), Gaps = 4/309 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +GAPIYVRHE+VHNRYVVD+L + GAIF+EQ Sbjct: 28 RVLLAEPRGYCAGVDRAVETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTD 87 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GAI++FSAHGV+ V EA +R L DATCPLVTKVH E R +R + +L+GH Sbjct: 88 EVPEGAIVVFSAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGH 147 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ + + +V++PD V K+TV++ K+ +++QTTLSVD+T + + L Sbjct: 148 EGHEEVVGTAGEAPD---HVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDETMETVRRL 204 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK- 240 R++FP + P DDICYAT NRQ AV+A+A + E+V+VVGSKNSSNS RL E+A G Sbjct: 205 REKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKNSSNSVRLVEVALGAGAS 264 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A L+D A DI W V VGVT+GAS P+ILV+ V+ RL + G P+ E + Sbjct: 265 AAHLVDYADDIDPAWFDGVTTVGVTSGASVPEILVRGVLDRLAEHGYDVVQPVTTANETL 324 Query: 301 VFEVPKELR 309 VF +P+E+R Sbjct: 325 VFALPREIR 333 >UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Bacteria RepID=ISPH_RHOBA Length = 319 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 156/309 (50%), Positives = 212/309 (68%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA PRGFCAGV+ AI ++ L +G P+YV HE+VHN++VV + RE+GA+F++ I Sbjct: 4 MKIILAAPRGFCAGVNMAIDSLDLTLQKFGPPVYVYHEIVHNQFVVKTFREKGAVFVDTI 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVP+G +L+FSAHGVS +R A++R L DATCPLVTKVH+E + ++ G ILIG Sbjct: 64 DEVPEGGVLLFSAHGVSPEIRKAAQARKLHALDATCPLVTKVHLEAIKYAKAGYTIILIG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ + LVE DV +L + +L+++TQTTLSVDD VI Sbjct: 124 HEGHDEVLGTMGEAP---EAIVLVEDEADVDRLEFEPGTQLAYLTQTTLSVDDAGRVIRR 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR+RFP+I P KDDICYAT NRQEAV+ L E A+V++V+GS+NSSNS RL ELA GK Sbjct: 181 LRERFPEIHSPPKDDICYATQNRQEAVKLLREDADVIVVLGSQNSSNSQRLKELAAEQGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 RA L+D +D+ + + V +TAGASAP+ +VQ+ + L++ REE++ Sbjct: 241 RAMLVDGPQDLAVDQFSDDDRVLITAGASAPESVVQSTIDWLKENFDASVDTQVVREEDV 300 Query: 301 VFEVPKELR 309 F +PK LR Sbjct: 301 QFPLPKPLR 309 >UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium RepID=B2HKN9_MYCMM Length = 333 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 162/313 (51%), Positives = 215/313 (68%), Gaps = 7/313 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 +LLA+PR FCAGV RAI VE L P+YVR ++VHNR VV L++RGAIF++++ E Sbjct: 24 VLLASPRSFCAGVHRAIEAVERVLDRATGPVYVRKQIVHNRTVVAELQDRGAIFVDELDE 83 Query: 63 VPD----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +PD GA+++FSAHGVS AVR A R L V DATCPLVTKVH E AR + RG+ +L Sbjct: 84 IPDPPAPGAVVVFSAHGVSPAVRAAANGRGLEVVDATCPLVTKVHAEAARFAGRGDTVLL 143 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IGH GH E +GT+G N M LV++ DDV +L + + ++S++TQTTL+VD+T+DVI Sbjct: 144 IGHLGHEETDGTLGVAPN---SMLLVQNADDVTELDLPEDAQVSYLTQTTLAVDETTDVI 200 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 DALRKRFPK+ P +DICYATTNRQ AV A+ + + +LVVGS+NSSNS RL ELA+R Sbjct: 201 DALRKRFPKLAEPPTEDICYATTNRQRAVEAIVRRCDALLVVGSQNSSNSQRLVELARRR 260 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 G A+LID DI W+ +G+TAGASAP LV+ V+ L+ G + E Sbjct: 261 GTPAYLIDGPTDIDPHWLDSTATIGITAGASAPPRLVEQVIDALRLRGPINVVESPVTTE 320 Query: 299 NIVFEVPKELRVD 311 ++ F +P ++RV Sbjct: 321 SVRFALPPKVRVP 333 >UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Chlamydiales RepID=ISPH_PARUW Length = 313 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 149/308 (48%), Positives = 208/308 (67%), Gaps = 3/308 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++LL+ PRGFCAGV+RAI VE AL ++G+PIYV+HE+VHNR+VV L+ +GAIFIE + Sbjct: 1 MKLLLSKPRGFCAGVERAIETVEKALLLWGSPIYVKHEIVHNRHVVQGLKTKGAIFIEDV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP GA LI+SAHGVS AVR +AK R L DATC LVT+VH V R + +G + ILIG Sbjct: 61 EDVPVGARLIYSAHGVSPAVREQAKKRQLIEIDATCGLVTRVHSAVKRYALQGYQIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H H E+ GT G+ + +VES +DV L +++KL ++TQTTLS+DD ++ A Sbjct: 121 HHNHVEIIGTAGEAPD---VTTIVESVEDVKNLNFSSQDKLFYITQTTLSLDDVKEITQA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L ++P + ICYATTNRQ A+R + + ++VLVVG SSNSNRL E A G Sbjct: 178 LIVKYPHVETLPSSSICYATTNRQMALREITDLTDLVLVVGDPQSSNSNRLREAASTRGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 ++LI+D K+I EW+ + +G+TAGAS P+ +VQ + L +LG E + E++ Sbjct: 238 ESYLINDEKEIHPEWLLGKQVIGLTAGASTPEEIVQKCIQCLIELGVNEVEDIVYTHEDV 297 Query: 301 VFEVPKEL 308 VF++PK + Sbjct: 298 VFQLPKPI 305 >UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=14 Tax=cellular organisms RepID=ISPH_CHLTB Length = 307 Score = 382 bits (983), Expect = e-105, Method: Composition-based stats. Identities = 144/308 (46%), Positives = 204/308 (66%), Gaps = 4/308 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+L +PRGFCAGV RAI VE AL +G PIYV+HE+VHNR+VVD LRE+GAIFIE + Sbjct: 3 KIILCSPRGFCAGVIRAIQTVEVALEKWGRPIYVKHEIVHNRHVVDKLREKGAIFIEDLQ 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP + +IFSAHGV ++R EA R L DATC LVTKVH V +++G ILIG Sbjct: 63 EVPRNSRVIFSAHGVPPSLREEATERGLIAIDATCGLVTKVHSAVKMYAKKGYHIILIGK 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+ G G+ + + +VE+ +V L ++ L ++TQTTLS+DD +D++ AL Sbjct: 123 RKHVEIIGIRGEAPD---QITVVENIAEVEALPFSAQDPLFYVTQTTLSMDDAADIVAAL 179 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + R+P+I ICYAT NRQ A+R + Q + V V+G + SSNSNRL E+A+R G Sbjct: 180 KARYPQIFTLPSSSICYATQNRQGALRNILPQVDFVYVIGDRQSSNSNRLREVAERRGVT 239 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE-GREENI 300 A L++ ++ EE ++ +G+TAGAS P+ +VQ + +LQ+L +I ++ EE+ Sbjct: 240 ARLVNHPDEVTEEILQYSGNIGITAGASTPEDVVQACLMKLQELIPDLSIEMDLFVEEDT 299 Query: 301 VFEVPKEL 308 VF++PKEL Sbjct: 300 VFQLPKEL 307 >UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTX4_9ACTO Length = 336 Score = 379 bits (974), Expect = e-104, Method: Composition-based stats. Identities = 147/334 (44%), Positives = 208/334 (62%), Gaps = 29/334 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA++ V+ AL +YG PIYVR E+VHN++VV +L GAIF+ ++S Sbjct: 3 KVLLASPRGYCAGVDRAVTAVQRALEVYGQPIYVRKEIVHNKFVVRTLAAAGAIFVNELS 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ ++FSAHGV+ +V EA+ R L V DATCPLV+KVH E R + G + ILIGH Sbjct: 63 EVPSGSRVVFSAHGVAPSVYAEAEQRGLEVIDATCPLVSKVHREARRYANEGYDIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVES-------------------------PDDVWKLTVK 156 GH EVEGT G ++++++ D + L+ Sbjct: 123 TGHEEVEGTSGVAP---EKIHVIDTDWIDTSESATTGTESADTTATGTPPADPLAGLSTD 179 Query: 157 NEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEV 216 + KL +++QTTLSVD T+ + L++RFP ++ P DDIC+AT NRQ AV+A+A+Q EV Sbjct: 180 PDAKLIWLSQTTLSVDQTAATVARLQRRFPGLISPPSDDICFATQNRQGAVKAMAQQCEV 239 Query: 217 VLVVGSKNSSNSNRLAE-LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILV 275 V+VVGS NSSNS RL E Q A+ I+ ++ +W +GVT+GAS P++LV Sbjct: 240 VIVVGSANSSNSVRLREVAVQAGAGAAYRIEGVHELNPDWFTGASTIGVTSGASVPEVLV 299 Query: 276 QNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 V+ L Q G E ++ +E F +PK LR Sbjct: 300 TEVLEWLAQHGFDEVQMVQTTQETTSFALPKPLR 333 >UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F698_ACIC5 Length = 338 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 162/307 (52%), Positives = 225/307 (73%), Gaps = 3/307 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LL PRGFCAGV RA+ IV AL +GAPIYVR E+VHNR+VV+ L E+GAIF+E I Sbjct: 21 KVLLLKPRGFCAGVVRAVDIVRIALETFGAPIYVRKEIVHNRFVVNELAEKGAIFVEDID 80 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+ +I+SAHGVS AVR ++K R+L V DATCPLVTKVH+E + +R+G +LIGH Sbjct: 81 QVPEGSRVIYSAHGVSPAVRQQSKDRNLRVIDATCPLVTKVHVEAVKFARQGYSLVLIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+EGT+G+ + +V S +V L V + +++++TQTTLS+D+ D+I+AL Sbjct: 141 RDHEEIEGTLGEAPD---VTTVVSSAAEVAALEVPDPNRVAYLTQTTLSLDEARDMIEAL 197 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +K+FP IVGP DICYAT NRQ AV+ +A QA++VLVVGS NSSNSNRL E+++ +G + Sbjct: 198 KKKFPNIVGPHSQDICYATENRQVAVKNVAHQADLVLVVGSNNSSNSNRLVEVSRNLGTK 257 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 +LID++K I+ EW++ V V VTAGASAP++LV++VV L G G +E EN+ Sbjct: 258 GYLIDNSKAIRPEWLEGVATVAVTAGASAPEVLVEDVVKYLGSKGFGSVEEVEVMPENVR 317 Query: 302 FEVPKEL 308 F +P E+ Sbjct: 318 FGLPPEI 324 >UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Aquificales RepID=ISPH_AQUAE Length = 289 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 92/290 (31%), Positives = 160/290 (55%), Gaps = 5/290 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I++A GFC GV RA+ + E +L +Y ++HN V+ L+ G F Q E Sbjct: 4 IIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLGV-FPSQGEE 62 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 +G +I +HG+ + + L V DATCP V VH V + +R G +L+G Sbjct: 63 FKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVGEK 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPEV GT+G G +VE+ +D+ + E++ + QTT + + +V+ + Sbjct: 123 NHPEVIGTLGYLRACNGKGIVVETLEDIGEAL--KHERVGIVAQTTQNEEFFKEVVGEIA 180 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 ++ + IC AT+ RQE+V+ LA + +V++++G KNS N+ RL +++ + Sbjct: 181 LWVKEVKVI--NTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNPNT 238 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 + I+ A+++Q EW + VK VG++AGAS PD +++ V +R+Q++ G+ + Sbjct: 239 YHIETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLVS 288 >UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_BUCA5 Length = 319 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 171/308 (55%), Positives = 237/308 (76%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+L NPRGFCAGV RAI IVENAL +Y IY+RHE+VHN+YV+++LR++G +F+E+I Sbjct: 1 MNIILTNPRGFCAGVKRAILIVENALKVYKKTIYIRHELVHNQYVINTLRQKGVVFVEKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++PD +++IFSAHGVS+ V EA + L + DATCPLV KVH+EV+++S + E+ILIG Sbjct: 61 EQIPDYSVVIFSAHGVSKKVVQEAVKKKLIILDATCPLVEKVHIEVSKSSEKAIETILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GHPEVEGT+GQY+N G +YLVES +DV L+V+N +KL+F TQTTLS+ +T +I A Sbjct: 121 HRGHPEVEGTIGQYNNKNGKIYLVESIEDVHNLSVQNSKKLNFFTQTTLSITNTKKIIAA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ +FP+I GP K+DICYATTNRQ AVR L++ A+++ V+GS NSSNSNRLAEL + G Sbjct: 181 LKNKFPEISGPNKEDICYATTNRQIAVRQLSKIADIIFVIGSNNSSNSNRLAELGKETGT 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 LI DI+++W+K V +G+TAGASAP+ILV V+ L+++G + I + G E Sbjct: 241 FTKLISSFLDIKKKWLKNVNYIGITAGASAPEILVTEVIQYLRKIGAHKPIEMIGVREKK 300 Query: 301 VFEVPKEL 308 +F++PK+L Sbjct: 301 IFKIPKKL 308 >UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organisms RepID=B3SF22_TRIAD Length = 470 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 147/296 (49%), Positives = 219/296 (73%), Gaps = 3/296 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +ANPRGFCAGV+RA+ IVE LA YGAP+YVRHE+VHNRYVV++L+ +GAIF+E+I Sbjct: 11 LEIFMANPRGFCAGVERAVEIVELTLAKYGAPVYVRHEIVHNRYVVENLKNKGAIFVEEI 70 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+PD A+ I+SAHGVS+ V NE++ + L + DATCPLV KVH++ + + G++ I+IG Sbjct: 71 AEIPDNAVTIYSAHGVSEKVENESRFKHLKIIDATCPLVKKVHLQAQKFEKVGDKIIIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+EGT G+ + +++VE+ DV K+ +E +S++TQTTLSVDDT ++IDA Sbjct: 131 HKNHPEIEGTSGRV---KREVFIVENIQDVEKIPFSKDESISYVTQTTLSVDDTKNIIDA 187 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ FP I GP +IC+AT NRQ+AV+ LA + + V+G+KNSSNSNRL ++A+ G Sbjct: 188 LKNAFPNIKGPELKNICFATQNRQDAVKQLASLVDTIFVIGAKNSSNSNRLRDIAENCGT 247 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 +AFL++ D + + +G+TAGASAP+ILV N++A+++++ + +EG Sbjct: 248 KAFLLNGETDDISDLLHNSTKLGITAGASAPEILVSNLIAKIKKMRDVKITHVEGT 303 >UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7 Tax=Clostridiales RepID=A3DDC0_CLOTH Length = 694 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 98/303 (32%), Positives = 164/303 (54%), Gaps = 6/303 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV A+ V N L PIY ++HN VVD +G I+ I Sbjct: 1 MEIIVAKSAGFCFGVSNAVKTVNNLLENQKEPIYTYGPIIHNAQVVDLFTSKGVKKIDDI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E ++ AHGV+ + + + L + DATCP V K+H V S G + I++G Sbjct: 61 DEAEPNGHIVIRAHGVTPDIYKKISDKGLILEDATCPYVKKIHNLVKEKSEEGYKIIIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G G +N Y+V+S DDV K + EK+ + QTT++ + +V A Sbjct: 121 DRNHPEVIGINGWCNN---QAYIVDSVDDVEKFPTSD-EKVCVVAQTTITNEKWLEVNTA 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+K+F I + D IC AT+ RQ +A+ ++++++G KNSSN+ +L ++ ++ Sbjct: 177 LKKKFKNI--LKFDTICSATSRRQNEAEEIAKNVDMMIIIGGKNSSNTQKLYDICKKHCN 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 + I+ + D+ +K++K VG++AGAS PD +++ V+ ++ +L + + + I Sbjct: 235 LTYKIETSGDLPPVDIKKIKKVGISAGASTPDWVIEEVIKKMSELNKQGMVDILENDGEI 294 Query: 301 VFE 303 F Sbjct: 295 DFA 297 >UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepID=A7AME9_BABBO Length = 419 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 140/316 (44%), Positives = 191/316 (60%), Gaps = 5/316 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L PRGFCAGV RAI VE A+ I+G PIYV+HE+VHN +V ++L+++G IFIE I Sbjct: 85 VFLLEPRGFCAGVRRAIETVEEAVRIFGPPIYVKHEIVHNEFVCNTLKKKGVIFIEDIET 144 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VP+G+IL+ SAHGV +V K R+L DA+CPLV KVH+ V + + G + ILIGH Sbjct: 145 VPEGSILVLSAHGVPPSVHEMVKKRNLVEIDASCPLVNKVHVYVRKKAEEGYKIILIGHK 204 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H E GT+G+ + +VE+ DDV +L + L + TQTTLSVDD + D L Sbjct: 205 SHVETIGTLGEAPD---VTTVVETVDDVDRLEYSRDTPLFYATQTTLSVDDCKIIKDRLL 261 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +RFP I ICYATTNRQ AVR ++VLVVGS SSN+NRL + A RA Sbjct: 262 ERFPWIETIPSGSICYATTNRQFAVRDACNFCDLVLVVGSSLSSNANRLVDTANLRNVRA 321 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV- 301 LI +A I EE + + + + ++A AS PD L +VV +L I + + V Sbjct: 322 HLIPNADAITEELIGDARKIALSASASTPDELTADVVKKLAVPPYNYNIEIYHSCDERVP 381 Query: 302 -FEVPKELRVDIREVD 316 + +P+ L + I+E D Sbjct: 382 KWRLPRNLELYIKEHD 397 >UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4 Tax=Veillonellaceae RepID=A1HTW2_9FIRM Length = 655 Score = 365 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 99/297 (33%), Positives = 163/297 (54%), Gaps = 10/297 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA RGFC GV RAI I P+Y ++HN +V L E+G + + Sbjct: 1 MKIILAEYRGFCYGVKRAIETAY--ACIGQGPVYTLGPIIHNPQLVQRLSEQGVVMANTL 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++P G +I +HGV V ++A++R L V DATCP V K + + +G ++G Sbjct: 59 EQIPAGR-VIIRSHGVGPEVYDQARARSLEVVDATCPHVRKAQQAARQLAEKGYYVAVVG 117 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ + + +VE+P D L E+L + QTT + D + ++D Sbjct: 118 EPNHPEVKSIVAWAG---ERVTVVETPADAQNLPY--HEQLGVVAQTTFASDQFNTIVDI 172 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + +I R IC AT RQ+A LA + +V++VVG KNS+N++RLAEL + G Sbjct: 173 LKTKCREIEVSR--TICTATDQRQQAAIKLARKVDVMVVVGGKNSANTSRLAELCRLQGC 230 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 + ++ A++++ +W V+ VG+TAGAS PD +++ V +++Q+ ++ E Sbjct: 231 PTYHVETAQELKIDWFTGVQTVGITAGASTPDWIIEEVYSKMQEFDQLLDQDMKPLE 287 >UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_PLAF7 Length = 535 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 127/316 (40%), Positives = 188/316 (59%), Gaps = 5/316 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L NPRGFC GV RAI VE L ++ PIYV+H++VHN V L + GAIFIE +++ Sbjct: 222 LYLINPRGFCKGVSRAIETVEECLKLFKPPIYVKHKIVHNDIVCKKLEKEGAIFIEDLND 281 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VPDG ILI+SAHG+S +R AK + L DATCPLV KVH+ V ++ + ILIG+ Sbjct: 282 VPDGHILIYSAHGISPQIREIAKKKKLIEIDATCPLVNKVHVYVQMKAKENYDIILIGYK 341 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H EV GT Y+ ++VE+ +DV KL +KL ++TQTTLS+DD + ++ L+ Sbjct: 342 NHVEVIGT---YNEAPHCTHIVENVNDVDKLNFPLNKKLFYVTQTTLSMDDCALIVQKLK 398 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +FP I ICYATTNRQ A+ + + ++ +VVGS +SSN+ +L +Q A Sbjct: 399 NKFPHIETIPSGSICYATTNRQTALNKICTKCDLTIVVGSSSSSNAKKLVYSSQIRNVPA 458 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP-LEGREENI- 300 L++ D+ ++ +K V + +T+ AS P+ Q V L + +G EN+ Sbjct: 459 VLLNTVHDLDQQILKNVNKIALTSAASTPEQETQKFVNLLTNPPFNYTLQNFDGAHENVP 518 Query: 301 VFEVPKELRVDIREVD 316 +++PK L I+E + Sbjct: 519 KWKLPKNLLHMIKERE 534 >UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Bacteria RepID=ISPH_THEP3 Length = 288 Score = 362 bits (931), Expect = 8e-99, Method: Composition-based stats. Identities = 95/292 (32%), Positives = 163/292 (55%), Gaps = 10/292 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+IL+A GFC GV RAI + G IY E++HN V+ L ++G IE+ Sbjct: 1 MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEE 60 Query: 60 --ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + ++ +G LI +HGVS+ + + + + V D TCP V KV V +G I Sbjct: 61 EELDKLTEGDKLIIRSHGVSKKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSII 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 ++G HPEV G G + Y+V S ++ ++L EK + QTTL D+ Sbjct: 121 IVGDRNHPEVIGVNGWCDDT---AYVVNSIEEAYEL--PQLEKACAVAQTTLIEKHWKDI 175 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 ++ ++ + ++ + IC AT RQ+A L+++ +V+ V+G K+SSN+ +L ++ ++ Sbjct: 176 LEVIKLKVKDLIF--FNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEK 233 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 K F I+DA+++ E VK+ + +GVTAGAS PD ++++V+ +++ L G + Sbjct: 234 NCKNTFHIEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGED 285 >UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=A1A2C9_BIFAA Length = 343 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 153/333 (45%), Positives = 209/333 (62%), Gaps = 28/333 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYG-------APIYVRHEVVHNRYVVDSLRERGA 54 +I+LA+PRGFCAGVDRAI V L P+YVR ++VHN++VV+ L +GA Sbjct: 13 RIVLADPRGFCAGVDRAILTVRTILKSADTPRADGLPPVYVRRQIVHNKHVVEDLAAQGA 72 Query: 55 IFIEQISEVPD-----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA 109 +F+++++E+PD G ++FSAHGVS AV+ EA +R + V DATCPLV+KVH EV R Sbjct: 73 VFVQELAEIPDAAAEAGIPIVFSAHGVSPAVKAEATARGMHVVDATCPLVSKVHREVLRF 132 Query: 110 SRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTL 169 + G E I IGH GH E G + ++L+E DV L + + KL +TQTTL Sbjct: 133 VKEGYEIIYIGHKGHDEAVGVV---EESPEHVHLIEHASDVDSLDFQPDTKLVLLTQTTL 189 Query: 170 SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSN 229 SVD+T+ I AL+ RFP + P DICYAT+NRQ AV+ +AEQA+ V++VGS NSSNS Sbjct: 190 SVDETAGTITALKARFPWLEMPPNSDICYATSNRQAAVKLVAEQADCVVIVGSANSSNSV 249 Query: 230 RLAELAQR-------------MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQ 276 RL E+AQ RA +DDA ++ W + V+ VG+++GAS PD LV Sbjct: 250 RLMEVAQEGLSARYASKTAVGAAGRAHRVDDASELDPAWFEGVESVGISSGASVPDELVS 309 Query: 277 NVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 VVA LQ+LG + +E +EN+ F +P ELR Sbjct: 310 GVVAALQELGYQDVSTIETIKENMHFVLPAELR 342 >UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=ISPH_BIFLO Length = 352 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 149/328 (45%), Positives = 211/328 (64%), Gaps = 22/328 (6%) Query: 3 ILLANPRGFCAGVDRAISIVE---NALAIYGA--------PIYVRHEVVHNRYVVDSLRE 51 ++LA+PRGFCAGVDRAI V+ A G P+YVR ++VHN++VV+ L Sbjct: 27 VVLADPRGFCAGVDRAILTVQTILKAAEASGKRTREDGLPPVYVRRQIVHNKHVVEDLAG 86 Query: 52 RGAIFIEQISEVPD-----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 +GA+F+++++E+PD G ++FSAHGVS V+ EA+ R + V DATCPLV KVH EV Sbjct: 87 QGAVFVQELAEIPDAAAQAGIPVVFSAHGVSPVVKAEAERRGMHVVDATCPLVGKVHREV 146 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQ 166 R R G E + IGH GH E G +G+ ++L+E DV L + KL ++Q Sbjct: 147 LRFVREGYEIVYIGHKGHDEAVGVVGESP---EHVHLIEHESDVDSLDFAPDTKLVLLSQ 203 Query: 167 TTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSS 226 TTLSVD+T+D I AL+ +FP I P DICYAT+NRQ AV+ +A+Q++ V++VGS NSS Sbjct: 204 TTLSVDETADTIAALKAKFPWIQEPPSSDICYATSNRQAAVKLVAQQSDCVVIVGSANSS 263 Query: 227 NSNRLAELAQR-MGKR--AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 NS RL E+AQ +G+R A+ +DDA ++ W + ++ VG+++GAS PD LV V+ LQ Sbjct: 264 NSVRLMEVAQEGLGERGKAYRVDDASELDPAWFEGLESVGISSGASVPDELVSGVIDALQ 323 Query: 284 QLGGGEAIPLEGREENIVFEVPKELRVD 311 LG +E +EN+ F +P ELR Sbjct: 324 NLGFTGMKSVETIKENMHFVLPAELRRK 351 >UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Clostridiaceae RepID=ISPH_CLOD6 Length = 279 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 86/285 (30%), Positives = 155/285 (54%), Gaps = 6/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A GFC GV RA+ + + + + IY ++HN+ V E+G + +I Sbjct: 1 MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQAVAKYEEKGLKTVNEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P+ +I +HGV + + EAK + L + D TCP V K+H V+ +G E I+IG Sbjct: 61 DTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKIHTVVSEYHNKGYEIIVIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G G N ++++ + + + N ++ + QTT++ + +++ Sbjct: 121 DMKHPEVIGINGWCEN---SAIIIKTLEQMENMEFDNSKRYCLVAQTTINPELYISIVNK 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +IV D IC AT RQE+ + LA++ + ++V+G K+SSN+ +L ++ + + Sbjct: 178 LSDKLEEIVF--NDTICSATKTRQESAKELAKEVDCMIVIGGKHSSNTQKLVKVCEDL-V 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ ++ +K+ K +G+TAGAS P+ +++ VV L+ L Sbjct: 235 PTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFLENL 279 >UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FLP4_DESAA Length = 576 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 99/286 (34%), Positives = 154/286 (53%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC GV RA+ +V + P+Y ++HN V+ L E+G +E+I Sbjct: 1 MKITIAKTSGFCMGVRRAVEMVLDTANRVKGPVYTFGPLIHNPQVMHMLAEKGVEVLEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G +LI AHGV+ R ++ TV DATCP V KV + + G I++G Sbjct: 61 PEKGEGTVLI-RAHGVTPETRGRLEAAGFTVIDATCPRVIKVQRLLDKYQAEGYTPIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV G +G G Y+V S ++ L + EK + QTT ++++A Sbjct: 120 DADHPEVIGLVGHA---RGHAYVVRSREEA--LNLPKGEKAVLVAQTTQDQVLYLNILEA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R+RF +I + IC +T RQE R LA Q E ++VVG K+S N+ RLA++A G Sbjct: 175 VRERFDEI--KDFNTICDSTARRQEEARGLAHQVEAMVVVGGKSSGNTQRLAQIAAGSGV 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 F ++ K++ + ++ VG+TAGAS P+ +++ V + G Sbjct: 233 PTFHVETEKELDVTKFQGMEHVGITAGASTPNWIIRRVHQAVADPG 278 >UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonella RepID=D1BMA5_VEIPT Length = 632 Score = 360 bits (926), Expect = 2e-98, Method: Composition-based stats. Identities = 100/298 (33%), Positives = 159/298 (53%), Gaps = 11/298 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV RA+ + A G Y ++HN VV L ++G ++++ Sbjct: 1 MEIILAENHGFCYGVKRAVEMANEAANNDGKS-YTLGPIIHNPQVVGRLEDKGVSPVQEV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S++ +G +I +HGV A+ EA+ + L V DATCP V K + G +++G Sbjct: 60 SDIVEG-TMIIRSHGVGPAIYEEAEEKGLHVVDATCPYVKKAQQDAKSVIDEGMTLVILG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ +N ++E + KL V EK+ + QTT S + +ID Sbjct: 119 EKNHPEVKSINLWANNEG---IIIEDEESAQKLQV--VEKMGVVVQTTFSQFKFNSIIDI 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K+ + IC AT RQ + LA ++++V+G KNS N+NRLAE+ + +G Sbjct: 174 LEKKSKNL--KVFKTICNATQERQNSAVDLARNVDLMIVIGGKNSGNTNRLAEVCRDVGC 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + I+ + ++Q EW V+ VGVTAGAS PD +++ V+ ++ E + EG+EE Sbjct: 232 ATYHIETSTELQLEWFNRVQTVGVTAGASTPDWIIKEVIETMKDF--AELLAAEGQEE 287 >UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_GEOBB Length = 283 Score = 360 bits (924), Expect = 4e-98, Method: Composition-based stats. Identities = 102/290 (35%), Positives = 153/290 (52%), Gaps = 8/290 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ++LA GFC GV RA + A I G+ Y ++H+ VV L E G I ++ + Sbjct: 1 MQVILAKHAGFCFGVKRATQLAFQAANI-GSETYTLGPIIHSPQVVQRLEEMGVIPVDNV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEV G +I +HGV+ A +L V DATCP V K VA S+ G + +++G Sbjct: 60 SEVETGGTIIIRSHGVAAEELEAAVRANLEVVDATCPFVKKAQEHVATLSKEGYDIVVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + + G +Y+V S DV +L K+ + QTT S + +V+ A Sbjct: 120 DAVHPEVQGIVSYAA---GRVYVVSSHKDVERL--PRMSKIGVVAQTTQSFEHLHEVVAA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 R + + IC AT RQE + LA + ++V+G NS+N+ RLA++ + Sbjct: 175 CLARGGEA--RVYNTICDATAVRQEEAKKLAGAVDCMVVIGGFNSANTMRLAQICLELLP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 R ++ A I E+W K VK VGVTAGAS P ++ V+ R+ + + Sbjct: 233 RTHHVETASQIDEQWFKGVKKVGVTAGASTPKWIIDEVIDRISAIDKDKI 282 >UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Desulfuromonadales RepID=ISPH_GEOLS Length = 280 Score = 359 bits (923), Expect = 7e-98, Method: Composition-based stats. Identities = 97/286 (33%), Positives = 151/286 (52%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA + A A + ++H+ VV+ L E G ++ + Sbjct: 1 MKVILAKRAGFCFGVKRATQMAFEA-AGKDQKTFTLGPIIHSPQVVNKLEEMGVGVVKDL 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S V +G +I +HGV + +EA + L V DATCP V K V S G + +++G Sbjct: 60 SGVSNG-TVIIRSHGVLASEMDEAHQKQLEVVDATCPFVKKAQEHVQYLSEAGYDVLVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + + +Y+V S D V +L K+ + QTT S D+ V+ Sbjct: 119 DADHPEVQGIVSY---GKEKVYVVASGDQVKQL--PKMGKMGVVAQTTQSFDNLKSVVTE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R ++ + IC AT RQ+ LA+Q + ++V+G NS+N+ RLAE+ + Sbjct: 174 CLRRGGEV--RVYNTICDATAVRQQEATELAQQVDCMIVIGGFNSANTRRLAEICTEIQP 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 R + I+ A +I W + V VGVTAGAS P ++ V+ RL Q+ Sbjct: 232 RTYHIETAAEIDCSWFQGVDTVGVTAGASTPKWIIDEVMNRLDQVN 277 >UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Neorickettsia RepID=ISPH_NEOSM Length = 303 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 134/307 (43%), Positives = 211/307 (68%), Gaps = 8/307 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 MQI +A PRGFCAGV+RAI VE A+ Y I+V HE+VHN V+ + RG FIE Sbjct: 1 MQIFVACPRGFCAGVERAIETVEIAIRRYPEKKIFVYHEIVHNSRVIQDFKARGVDFIED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I++V ++LIFSAHGVS+ + KS DL + DATCPLV+K+H EV R + G ++I Sbjct: 61 ITKVEPKSVLIFSAHGVSEEIEKYVKSLDLVLVDATCPLVSKIHREVQRFEKEGFIILVI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G+ H E+ GT+G+ + Y+V+ P+D+ L KL+++TQ+TL+++ TS +I+ Sbjct: 121 GNRNHAEIIGTVGR---TKTQAYIVQDPEDIDNLP-SITGKLAYVTQSTLALEYTSTMIN 176 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ++++FP +VG D+CYAT NRQEAV+ALA++ +++L+VGS NSSNS L +++ ++ Sbjct: 177 KIKEKFPNVVGRS--DVCYATQNRQEAVKALAKEVDLMLIVGSTNSSNSRNLMQVSSKIC 234 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ-LGGGEAIPLEGREE 298 ++AFLID+ +++ +W + V VG+++GASAP+ILVQ++V+ L++ E + +EE Sbjct: 235 QKAFLIDNYNEVEPDWFEGVDRVGISSGASAPEILVQDLVSFLKKRFPSAEVSDFKFKEE 294 Query: 299 NIVFEVP 305 + F++P Sbjct: 295 KVQFKLP 301 >UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LUA5_SYNAS Length = 577 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 94/288 (32%), Positives = 157/288 (54%), Gaps = 11/288 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M + LA GFC GV RA+ V + G IY ++HN V+ LRERG I I+ Sbjct: 1 MSVFLAKTAGFCMGVKRAVDTVLDIARHKGSEKIYTYGPLIHNPQTVEFLRERGIIPIKD 60 Query: 60 ISEV---PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 I + A ++ AHG+S + R + +++ L + DATCP VT V + + + + Sbjct: 61 IEALSASDQNAAIVIRAHGISPSERKKIRNKGLRIIDATCPKVTHVQAIIRQHAAKDYNI 120 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 ++IG HPEV G + G ++ S +V +L + EK+ + QTT +V++ + Sbjct: 121 LIIGDGDHPEV---NGLLGHAGGHGRVIGSLQNVEELPI--MEKVCVVAQTTQNVEEYAA 175 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 ++ +R RFP+ V + IC +T RQ VR LA + E +++VG +NS+N+ RLA L+ Sbjct: 176 IVRRIRDRFPETV--VFNTICDSTEQRQAEVRELAARMEAMVIVGGRNSANTRRLAALSS 233 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + G F I+ A ++ + + +G++AGAS P+ ++ VV R+ + Sbjct: 234 QQGTPTFHIETADELNDAKLAPYDRIGLSAGASTPNWIIDRVVDRIAE 281 >UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q304_9BACT Length = 584 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 83/285 (29%), Positives = 155/285 (54%), Gaps = 10/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY--GAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 +++ +A GFC GV RA+ I+ +A GA +Y ++HN V++ L +R + Sbjct: 5 LKVFVAKTAGFCMGVRRAMDILLDAANEKNIGAKVYTDGPLIHNPQVLEYLEKRDLHIVN 64 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 ++++ + + ++ AHGV+ + R E +S+ V DATCP V +V + + + +G +I+ Sbjct: 65 DVTDLSN-STVVIRAHGVTPSRRAEIESKGAKVCDATCPHVMRVQSIIKKYAAQGYSTII 123 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G GH EV G +G EG ++VE+ +++ L +K+ + QTT I Sbjct: 124 VGDNGHAEVVGLLGYA---EGRGHVVENMENIELL--PPMDKVCIVAQTTQDRHLFKRAI 178 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 D +++R+P + IC +T RQ+ V L + + ++VVG + S+N+ RL + + Sbjct: 179 DEIKRRYPN--SESFETICSSTYKRQDEVVNLCKSVDAMIVVGGRGSANTTRLVTICESQ 236 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 G F ++ +I +K +GVTAGAS P+ +++ VV +++ Sbjct: 237 GTPTFHVETDSEIDLNKLKVFNTIGVTAGASTPNWMIKRVVDKVR 281 >UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=83 Tax=Alphaproteobacteria RepID=ISPH_BRUA1 Length = 346 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 153/313 (48%), Positives = 213/313 (68%), Gaps = 6/313 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I L PRGFCAGVDRAI IV AL YGAP+YVRHE+VHNRYVV+ L+ RGAIF+E++ Sbjct: 8 LEIRLCGPRGFCAGVDRAIQIVVLALKKYGAPVYVRHEIVHNRYVVEGLQARGAIFVEEL 67 Query: 61 SEVPD---GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+P ++FSAHGV ++V +A++++L DATCPLV+KVH + R R G I Sbjct: 68 DEIPAAHRNQPVVFSAHGVPKSVPADAEAKNLFYLDATCPLVSKVHKQAMRHQRLGRHVI 127 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 LIGH+GHPEV GTMGQ P+G + L+E+ +D +E+ L F+TQTTLSVDDT+ + Sbjct: 128 LIGHSGHPEVIGTMGQL--PDGAVTLIETVEDAHTCHFDDEDNLGFVTQTTLSVDDTAGI 185 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I L+ RFP + P + ICYATTNRQ+AVRA A ++ L+VG+ NSSNS RL E+A++ Sbjct: 186 IKELQARFPNLAAPAAESICYATTNRQDAVRAAAPGCDLFLIVGAPNSSNSKRLVEVAEK 245 Query: 238 MGKR-AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 G R + L+ A+DI+ E + ++ VG++AGASAP+I+V ++ + + E Sbjct: 246 AGARMSMLVQRAEDIEWEQIGDISVVGLSAGASAPEIIVDEIIDAFKARFDVKIELAETT 305 Query: 297 EENIVFEVPKELR 309 E F V +E+R Sbjct: 306 VETENFLVNREIR 318 >UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridia RepID=A4J3N5_DESRM Length = 672 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 96/305 (31%), Positives = 164/305 (53%), Gaps = 10/305 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RAI + + IY ++HN VV +L E G I I Sbjct: 1 MRIKLASKAGFCYGVKRAIDLALSTAKEKAGNIYTLGPLIHNPQVVQNLAENGICEINDI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV +G +I +HGV + A+ + L V DATCP V + + +G ++G Sbjct: 61 GEVKEG-TVIIRSHGVGPEIIQAAREKGLKVLDATCPFVARAQKYAHEMAAQGIPVYILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEV+G +G EG ++++P ++ ++ K+ + QTT + + +++A Sbjct: 120 DPGHPEVQGILGW---TEGKGSVIDNPSEITRVE---HPKVGVVAQTTQPLSNFQALLEA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + + ++ IC+AT RQ A LA + +V++VVG KNS+N+ +LA++ Q G Sbjct: 174 LQNQ--GVEVDARNTICHATGERQRAAMELAREVDVMVVVGGKNSANTKKLAKICQETGT 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 + ++ A+++++EW + VG+TAGAS PD +++ V R+ ++ EG E + Sbjct: 232 PTYHVESARELRKEWFLGHEIVGLTAGASTPDAIIEEVKKRMNEMDQMTNGE-EGMSEAM 290 Query: 301 VFEVP 305 + P Sbjct: 291 EVKSP 295 >UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Deinococci RepID=ISPH_THET2 Length = 340 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 142/324 (43%), Positives = 195/324 (60%), Gaps = 18/324 (5%) Query: 2 QILLANPRGFCAGVDRAISIVE---NALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++ LA PRGFCAGV AI VE AL G + V HE+VHNR VV+ L+ +G F+E Sbjct: 9 RVYLARPRGFCAGVVMAIEAVERWAEALKEKGELV-VYHEIVHNRVVVERLQAKGVHFVE 67 Query: 59 QISEVPD-------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 ++EV ++FSAHG AVR +A LTV DATCPLVTKVH E R ++ Sbjct: 68 DLAEVERLRRERRLADTVVFSAHGHPPAVRRQAAEMGLTVLDATCPLVTKVHTEAKRYAK 127 Query: 112 RGEESILIGH-AGHPEVEGTMGQYSNP----EGGMYLVESP--DDVWKLTVKNEEKLSFM 164 G +LIG A H E++GT G+ ++ + P D + V + E++ + Sbjct: 128 EGYWILLIGDSADHQEIKGTYGEAPERTILVAVHTHVGKDPRLADPRTVEVPDPERVVVL 187 Query: 165 TQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKN 224 TQTTLSVDDT I L+KRFPK+V P + D+CYAT NRQEAV+ +A + E LV+ S + Sbjct: 188 TQTTLSVDDTLATIAILKKRFPKLVVPSRKDLCYATQNRQEAVKRIAPKVEAFLVLTSPH 247 Query: 225 SSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 SSN RL ELAQ + RA+ ++ ++++ EW++ V+ +G+T+ AS P+ LVQ VVARL+ Sbjct: 248 SSNGMRLLELAQSLVGRAYRLERPEELRPEWLEGVESLGITSAASTPEDLVQGVVARLKA 307 Query: 285 LGGGEAIPLEGREENIVFEVPKEL 308 G + EG E I F PK L Sbjct: 308 QNPGLEVVEEGAWETIAFREPKPL 331 >UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZT29_DESOH Length = 577 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 90/284 (31%), Positives = 146/284 (51%), Gaps = 8/284 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV RA+ +V +A Y PIY ++HN V+ L E+ +E I Sbjct: 1 MKVSIAKTSGFCMGVRRAVDMVLDASNRYTEPIYTFGPLIHNPQVLRLLAEKKISVMETI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G I++ AHGV R + ++ TV DATCP V KV ++R + G I+IG Sbjct: 61 PEQGNG-IVLIRAHGVPPRTREKLEAAGFTVIDATCPRVVKVQTIISRNAAEGCAVIIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G + + +S + + L EK + QTT S +V Sbjct: 120 DKDHPEVVGLLGYAGD---RGVVADSLEALKALPA--FEKAIIVAQTTQSTRLFDEVGAW 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 P + IC +T NRQ ALA Q + ++VVG NS N+ RLA+++++ G Sbjct: 175 AAAHHPH--YQVFNTICPSTKNRQAETEALARQTDAMVVVGGYNSGNTQRLAQVSKKSGH 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 F ++ ++++ + + +G+TAGAS P+ +++ + L+ Sbjct: 233 PVFHVETSEELDTNALAKSDHIGITAGASTPNWIIKKIYRELEA 276 >UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Mobiluncus mulieris RepID=C2KTB4_9ACTO Length = 374 Score = 353 bits (906), Expect = 5e-96, Method: Composition-based stats. Identities = 139/375 (37%), Positives = 206/375 (54%), Gaps = 70/375 (18%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA+++V+ AL +GAP+YVR E+VHN++VV +L GA+F+ ++ Sbjct: 3 KVLLASPRGYCAGVDRAVTVVQRALERFGAPVYVRKEIVHNKFVVRTLAAAGAVFVSELH 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ +IFSAHGV+ AV EA++R L V DATCPLVTKVH E R + +G + ILIGH Sbjct: 63 EVPSGSRVIFSAHGVAPAVYAEAEARGLKVIDATCPLVTKVHREAKRFADQGYDIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------------- 153 GH EVEGT G + + ++++ DV L Sbjct: 123 QGHEEVEGTQGVAPD---RIRVIDTNQDVSILTGNQPETPGENPAPSPKERQDFGLAPGE 179 Query: 154 ---------------TVKNEEKLSFMTQTTLSVDDTS----------------------- 175 + E ++ + T + D T Sbjct: 180 SSPNPARNVVPGSQPELAPHESVNHVNHETAATDATDSATNGKRKMVWLSQTTLSVDQTN 239 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 + + L+ FP + P DIC+AT NRQ AV+A++ + +VV+VVGS NSSNS RL E+A Sbjct: 240 ETVARLKLHFPGLESPPSGDICFATQNRQGAVKAMSPKCDVVIVVGSANSSNSVRLMEVA 299 Query: 236 QRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE 294 + G ++ +D A ++ +W + K VG+T+GAS P++LV V+ L G + P+E Sbjct: 300 REAGAGASYRVDGAGELCADWFEGAKTVGLTSGASVPEVLVDEVLQWLAAHGFDDVEPVE 359 Query: 295 GREENIVFEVPKELR 309 EE F +P++LR Sbjct: 360 TLEETTRFALPRDLR 374 >UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FZU7_9CLOT Length = 280 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 92/286 (32%), Positives = 160/286 (55%), Gaps = 7/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL-AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I ++ GFC GV RA+ + L + IY ++HN+ V+ ERG + + Sbjct: 1 MNIKISEKAGFCFGVKRAMGLAWRELCEEHDKQIYALGPLIHNKQAVEKYEERGLVTADD 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I E+P +I +HGVS+++ + A ++L V D TCP V K+H V +G++ ILI Sbjct: 61 IEEIPSDVKMIIRSHGVSKSIYDRADEKELEVVDTTCPFVKKIHDIVKENYDKGKKIILI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G +N ++++ D+ +L + E + QTT++++ +++D Sbjct: 121 GDKNHPEVIGINGWCNN---SAIIIKTIDEAKELELDPEVDYCSVAQTTMNLEVYGNMVD 177 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+++ KI + IC +T RQEA R LA + + ++V+G K+SSN+ +L + + + Sbjct: 178 ILKQKSDKI--DFNNTICSSTKARQEAARELASEMDCMVVIGGKHSSNTQKLVGICKEVC 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ D+ E +K+ + VG+TAGAS PD ++ +++ L+ L Sbjct: 236 -PTFAIETRDDLDVEEIKKYENVGITAGASTPDWIIDDIIEYLKSL 280 >UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridiales RepID=B1I3Y7_DESAP Length = 677 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 92/285 (32%), Positives = 142/285 (49%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA GFC GV RAI + + PIY ++HN VV L E+G +E+I Sbjct: 1 MEVRLATKAGFCFGVHRAIDLALKTVRETAPPIYSLGPLIHNPQVVAYLAEQGIEVVEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 VP G LI +HGV + + + TV DATCP V + + G + I++G Sbjct: 61 ERVPRG-TLIIRSHGVEPKLLEKTRELGFTVVDATCPFVKRAQRLACDLNDSGHQVIVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G G +VE + L ++ + QTT + V++ Sbjct: 120 DRKHPEVRGIVGW---TNGQAVVVEDRVEASALPFYP--RVGVVAQTTQPHANLEAVVEE 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R +++ D IC A RQ A LA Q +V++VVG +S+N+ +L L + G Sbjct: 175 LKSRMGEVL--VCDTICNAVVERQNAALTLARQVDVMVVVGGIDSANTRKLTGLCRLSGT 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ +Q EW + G+TAGAS PD +++ V R+++L Sbjct: 233 PTYHIETGDQLQSEWFRGCTVAGLTAGASTPDWIIEEVKRRMEEL 277 >UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=delta proteobacterium MLMS-1 RepID=Q1NXJ4_9DELT Length = 361 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 90/285 (31%), Positives = 149/285 (52%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA+ + PI ++HN V+ L ++G +E++ Sbjct: 85 MKVILAKHAGFCMGVRRAVETTLELVEKSRGPIATFGPLIHNPQVLTMLGQKGVEVLEEV 144 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G ++I AHGV A + + V DATCP V KV + + R+G ++++G Sbjct: 145 PEQSQGTVVI-RAHGVPPARKQSLEESGAVVEDATCPRVVKVQAIIDKYRRQGYTTVIVG 203 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EVEG +G ++ S +++ L +K ++QTT + + Sbjct: 204 DRDHAEVEGLVGHAG---EVGLVISSMEELDGLELKPP--YIVVSQTTQDEEMFQLITAG 258 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + RFP G + IC +T RQ+ VR + Q + ++VVG +NS+N+ RLAE+A+ + Sbjct: 259 VLSRFPG--GKVFNTICDSTHKRQDEVREMCRQVDALVVVGGRNSANTKRLAEIARGLAC 316 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 FL++ ++Q E ++ + VGVTAGAS P ++ VV L+ L Sbjct: 317 PVFLVETEAELQFEQMRRYQSVGVTAGASTPVWSIRQVVDALEAL 361 >UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Leptospira RepID=ISPH_LEPIN Length = 330 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 138/313 (44%), Positives = 200/313 (63%), Gaps = 12/313 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I LANPRGFCAGV AIS VE A IYVR E+VHNR VV+ +++ G FI + Sbjct: 22 KIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDLD 81 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 E P+GA +IFSAHGVS +V AK R + + DATCPLVT+VH + + + + I IGH Sbjct: 82 EAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARK-IKDTHQIIYIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVDDTSDVID 179 GH E GTMG+ M+LVES +D+ L + + L+++ QTTLSV DT ++ID Sbjct: 141 EGHDEAIGTMGEAE-----MFLVESLEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIID 195 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K FP + P KDDICYATT RQEAV + ++ + +LV+G+ NSSNS RL +LAQ+ Sbjct: 196 QISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADNSSNSLRLLQLAQKSK 255 Query: 240 KRAFLIDDAKDIQEEWVKE--VKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL--EG 295 +F + A D+ +E+++ +K +G+TAGAS P +LV ++++L+ + L Sbjct: 256 PHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGS 315 Query: 296 REENIVFEVPKEL 308 R++++ F++P L Sbjct: 316 RDDSMNFKLPGVL 328 >UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Deinococcus deserti VCD115 RepID=C1CUR9_DEIDV Length = 334 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 133/320 (41%), Positives = 183/320 (57%), Gaps = 13/320 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERG-AIFIEQI 60 +I LA PRGFCAGV AI VE A P+ V H +VHN VV+ LR G F+E + Sbjct: 4 RIHLAKPRGFCAGVVMAIQAVEKAARTEEKPVTVYHSIVHNHTVVERLRAGGGVHFVEDL 63 Query: 61 SEVP----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + +G +IFSAHG+S VR A+ L DATCPLVTKVH E + +R G Sbjct: 64 DAIEALPENGETVIFSAHGISPVVRERARQLGLATIDATCPLVTKVHTEAKKYAREGYTI 123 Query: 117 ILIGH-AGHPEVEGTMGQYSNPEGGMYLV-------ESPDDVWKLTVKNEEKLSFMTQTT 168 +LIG A H EV GT G+ + + ++ +D + V + ++ +TQTT Sbjct: 124 LLIGDSARHQEVIGTRGEAPDHTILVGVLGQAHNEDSGLNDPHTVEVPDPSRVVVLTQTT 183 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 LSVDDT +D LR RFP +V P +D+CYAT NRQ+AV+A+A ++ LV+ S +SSN Sbjct: 184 LSVDDTRRTVDVLRSRFPALVVPPSEDLCYATKNRQDAVKAIAPVVDMFLVLTSTHSSNG 243 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 RL ELA+ + RA ++ D+Q + V+ VG+T+ AS PD LVQ VV + L Sbjct: 244 MRLLELARSLCGRAERLETVADLQMLDLSGVRSVGITSAASTPDDLVQAVVEHFRSLNPL 303 Query: 289 EAIPLEGREENIVFEVPKEL 308 + EG ENI F P+++ Sbjct: 304 LQVTEEGEWENIEFREPRKI 323 >UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KIS2_9FIRM Length = 275 Score = 346 bits (889), Expect = 6e-94, Method: Composition-based stats. Identities = 97/284 (34%), Positives = 149/284 (52%), Gaps = 10/284 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA+ GFC GV RAI I + G ++HN +VD LR G ++++ Sbjct: 1 MEVILADYLGFCYGVKRAIKIARENASADGTAC-TLGPIIHNPQMVDRLRREGVGSVDRL 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ G +I +HGV AV +EAK+R L V DATCP V K + G ++IG Sbjct: 60 EEMEKG-TVIIRSHGVGPAVYDEAKARGLEVVDATCPHVKKAQLSAKELVDEGYSVVIIG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ S G ++E+ D+ + KL + QTT S ++ Sbjct: 119 EKEHPEVKSIFEWSS---GKAQIIETEDEAEAVE--PCGKLGIVCQTTFSGARFRQIVMR 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L ++ I R IC AT RQ A LA + +++LV+G KNS+N+ RLA+L Sbjct: 174 LLEKSRDIRILR--TICTATDQRQAAAIDLASKVDLMLVIGGKNSANTTRLAQLCSEKCL 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + I+ A ++Q+EW ++K +G+TAGAS PD +++ V + Q Sbjct: 232 -TYHIETAAELQDEWFDKIKKIGITAGASTPDWIIKEVYKKCQN 274 >UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfitobacterium hafniense RepID=B8G2Q3_DESHD Length = 661 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 90/298 (30%), Positives = 154/298 (51%), Gaps = 11/298 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+ A GFC GV RA+ + E + ++HN+ VV+ + ++G + ++ Sbjct: 1 MKIIRAEKAGFCFGVKRALDMAERTVQSSSTA--SLGPLIHNQQVVEKMEKQGVRVVGEV 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G LI +HGV + EA+ + V DATCP V K A +S+ G + +++G Sbjct: 59 KETQAGDTLIIRSHGVPPDIYEEARRCQVKVVDATCPFVQKAQRLAAESSQSG-QVVVVG 117 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G G +E+ ++ +L E+LS + QTT + ++D Sbjct: 118 DRQHPEVQGILGWAG---GNAIAIETLEEARELPFY--EQLSVLAQTTQPAANFHGIVDE 172 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + + IC AT RQ R LA + +V++VVG KNS+N+ +LA + Sbjct: 173 LKTHTHAL--KVHNTICNATEERQTVARELAGKVDVMIVVGGKNSANTRKLAGICSER-T 229 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + +LI+ A ++++ W V VG+TAGAS PD +++ V ++ + E + E+ Sbjct: 230 QTYLIETADELEDNWFTGVVTVGLTAGASTPDWIIEEVYRKMSTMENKETHEMMNMED 287 >UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Deltaproteobacteria RepID=A0LJ95_SYNFM Length = 580 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 92/312 (29%), Positives = 156/312 (50%), Gaps = 17/312 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY--GAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M++L+A GFC GV A+ + A+ G I ++HNR V+ L +G + Sbjct: 1 MKVLVAKTAGFCKGVRDALEVTLGAIKNQQDGENICTFGPLIHNRQVLAMLEAKGIREVN 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +I D ++I AHG+ R T+ DATC V KVH + R +RRG +++ Sbjct: 61 EIEGCADRKVVI-RAHGIPPETRQTLHRLGATLLDATCKRVAKVHAAIKRHARRGYYTVI 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G A H EV G MG EG ++ + + +L + E + + QTT + + ++ Sbjct: 120 VGDADHAEVIGLMGY---TEGRGVVINRVEQLNELPAEW-ENVLLVAQTTQNEEVFQEIQ 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + K++PK G K+ IC +T RQ VR + E +++VG +S N+ RLA++A+ Sbjct: 176 EEFLKKYPK--GKVKNTICDSTHERQTEVREMCSLVEAMVIVGGFHSGNTLRLAQVAREC 233 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + ++ ++ + + + VGV+AGAS P+ L++NVV L+ + + P Sbjct: 234 EIPTYHVETEAELNPQELAKYSRVGVSAGASTPNWLIRNVVRFLESIRPEQPEP------ 287 Query: 299 NIVFEVPKELRV 310 F V K L + Sbjct: 288 --RFSVKKTLEL 297 >UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YH70_THEYD Length = 289 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 85/288 (29%), Positives = 152/288 (52%), Gaps = 8/288 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I+LA GFC GV RAI I + + ++ ++HN VV+ L++ G +++IS Sbjct: 4 NIVLAEGAGFCFGVKRAIDIAFDVAQKHKDGVFTLGPIIHNPQVVERLKDLGVYPVDEIS 63 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 + LI AHG+ + NE K D + DATCP V K + + G + ++IG Sbjct: 64 Q-KTIKTLIIRAHGIPKEKFNELKQLDCEIIDATCPFVKKAQNLAEKLASEGYQVLIIGD 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNE---EKLSFMTQTTLSVDDTSDVI 178 HPEV+G ++ D+ K + K +K+ + QTT + +++ Sbjct: 123 REHPEVKGIFSYAG---EKAIVINHADNELKESKKIPILNKKIGIIQQTTQPMSKVKEIM 179 Query: 179 DALRKRFPKIVG-PRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + + + + +C T+ R EA +A++ +V++VVG KNS+N+ +LA L ++ Sbjct: 180 NKIINSLNEFEEIRIFNTLCNFTSRRLEATEKVAKEVDVMIVVGGKNSANTTQLANLCRK 239 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +G + + I+DA++I ++WV K +GVTAGAS P ++ V+ ++++ Sbjct: 240 IGVKTYHIEDAQEIDKKWVNSAKKIGVTAGASTPQWIIDEVIDKIKKF 287 >UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1NAP1_9BACT Length = 309 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 138/305 (45%), Positives = 200/305 (65%), Gaps = 6/305 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I +A P G CAGV RA+ VE L AP+YV HE+VHN ++V+ L+ERG IF E ++ Sbjct: 6 KIFIARPHGMCAGVRRALDTVEAVLKSAPAPVYVLHEIVHNNFIVNRLKERGVIFAETLA 65 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GA+L+FSAHGVS AV EA+ R L DATCPLV + +++ R GE ILIGH Sbjct: 66 EVPEGAVLLFSAHGVSAAVEEEARRRSLRTVDATCPLVKSLQSAASKSFRPGEVLILIGH 125 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT-VKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEVEG +G+ G ++++ +V L + + ++QTTL+++ +V+ A Sbjct: 126 RGHPEVEGVLGRVPA-GGTVHVISGAAEVPGLPELPAGTPVRALSQTTLNLEAVDEVLAA 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR R+P++ +CYATTNRQ+AVR LA + +L++GS SSNSNRL E+A++ G Sbjct: 185 LRNRWPQLESGPG--VCYATTNRQKAVRQLAARCRTILIIGSPRSSNSNRLREIAEQAGA 242 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 RAFLID +++ + + +GV+AGASAP+ LV+ V RL++LG G + P+E E + Sbjct: 243 RAFLIDGPQELPP--LDPSQDIGVSAGASAPEELVEATVERLRRLGYGASEPVEAAVETV 300 Query: 301 VFEVP 305 F +P Sbjct: 301 AFRLP 305 >UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=58 Tax=Bacteria RepID=A9KLR6_CLOPH Length = 643 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 88/300 (29%), Positives = 161/300 (53%), Gaps = 14/300 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA GFC GV RA+ V ++ G +Y ++HN VV L ++G I + Sbjct: 1 MKITLAKTAGFCFGVKRAVDKVYEEISN-GKEVYTYGPIIHNDEVVKDLEDKGVKVIHSL 59 Query: 61 SEVP--DGAILIFSAHGVSQAVRNEAKS------RDLTVFDATCPLVTKVHMEVARASRR 112 E+ D ++ +HGV ++V ++ K ++ + DATCP V K+H V S Sbjct: 60 DELKKLDRGTIVIRSHGVPKSVLDQIKEIEETEGKNFDLVDATCPYVLKIHRIVKEQSEL 119 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G + I+IG HPEV G +G NP + +V + ++ K+ + +E+K+ + QTT + Sbjct: 120 GRQLIVIGDKEHPEVSGIIGWCKNP---VIVVGNAEEAEKIQLSSEQKVCIVAQTTFNYK 176 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 + ++++ + K+ I+ + IC AT RQ L++ +E ++V+G K+SSN+ +L Sbjct: 177 NFQELVEIISKKGYDIL--VLNTICNATEERQTEAAMLSKTSEAMIVIGGKHSSNTRKLY 234 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 E++++ + I D+ +K + VG+TAGAS P+ +++ V R+ ++ + + Sbjct: 235 EISKKECANTYYIQKLIDLDLNQLKSFRSVGITAGASTPNNIIKEVHTRMAEMSFEQLLE 294 >UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Meiothermus RepID=C1XXH1_9DEIN Length = 343 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 131/326 (40%), Positives = 185/326 (56%), Gaps = 21/326 (6%) Query: 2 QILLANPRGFCAGVDRAISIVENALAI--YGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 ++ LA PRGFCAGV AI VE A + V H +VHN VV L ++G F+E Sbjct: 4 RVYLAKPRGFCAGVVMAIQAVEKAAQELKEEGELVVYHAIVHNDVVVKRLEQQGVHFVED 63 Query: 60 ISEVPD------------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVA 107 ++EV ++FSAHG+ +R EA R L+ DATCPLVTKVH E Sbjct: 64 LAEVERLRKERRKAGAKLADTVVFSAHGIPPRLRTEAAQRGLSQIDATCPLVTKVHSEAK 123 Query: 108 RASRRGEESILIGH-AGHPEVEGTMGQYSNP----EGGMYLVESP--DDVWKLTVKNEEK 160 R ++ G +LIG A H E++GT G+ ++ P D ++ V + EK Sbjct: 124 RYAKEGYWILLIGDSADHQEIKGTRGEAPERTILVSVHTHVGRDPRLADPRRVEVPDPEK 183 Query: 161 LSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVV 220 + +TQTTLSVDDT I+ L+ RFPK+V P +DD+C+AT NRQ+AV+ +A ++ LV+ Sbjct: 184 VVVLTQTTLSVDDTLATIEILKARFPKLVVPSRDDLCFATKNRQDAVKQIAPHVDLFLVL 243 Query: 221 GSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVA 280 S SSN RL ELA+++ RA I+ D++ EW++ VK VG+T+ AS PD LVQ VV Sbjct: 244 TSTASSNGMRLLELAKQLVGRAERINTVADLKPEWLEGVKSVGITSAASTPDDLVQEVVG 303 Query: 281 RLQQLGGGEAIPLEGREENIVFEVPK 306 + + +G E+I F P+ Sbjct: 304 YFRSHNPALEVIEQGEWEDIEFREPR 329 >UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RIU7_MOOTA Length = 736 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 95/299 (31%), Positives = 143/299 (47%), Gaps = 16/299 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A+ GFC GV RA+ A P+ ++HNR VVD L G + + Sbjct: 1 MEVIVADYAGFCFGVKRAVEKAREA----PKPVASLGMLIHNRQVVDQLAREGVRPVASL 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G ILI +HG + A+ + L + DATCP V + + + G + I++G Sbjct: 57 DEVNCGRILI-RSHGTTPETLVRARDKGLEIIDATCPYVKRAQHLAQKMAAEGYQVIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G +G G +V L + + QTT +V A Sbjct: 116 DAAHPEVQGMLGWAG---PGAVVVPDKKAAAALPFHPRR--AVLAQTTQPESRLEEVAAA 170 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR +V + +C AT RQEA LA Q +V++VVG K S+N+ LAEL + G Sbjct: 171 LRSNTDTLV--VHNTVCQATHQRQEAAVRLARQVDVMVVVGGKESANTRHLAELCRATGT 228 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 + ++ A ++ +W + VGVT GAS P +++ VV L GE + EE Sbjct: 229 PTYHVERAGELCRQWFINTRRVGVTGGASTPAWIIEEVVGMLT----GEEKIMVPEEEK 283 >UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A4N7_NATTJ Length = 705 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 91/297 (30%), Positives = 158/297 (53%), Gaps = 19/297 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP---IYVRHEVVHNRYVVDSLRERGAIFI 57 M+IL+A GFC+GV+RA+ A+ + ++ +VHN+ V+ +L E+G I Sbjct: 1 MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGII 60 Query: 58 EQISEVPDGAI--------LIFSAHGVSQAVRNEAKSR-DLTVFDATCPLVTKVHMEVAR 108 E ++++ ++ +HGV + + V DATCP V KV + ++ Sbjct: 61 ENLTQLQSKKCLSEETNNYVVIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASK 120 Query: 109 ASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTT 168 + G + ++G HPEV+G N ++E P+ V + + N K + + QTT Sbjct: 121 LYQDGYQIFIVGDPNHPEVKGIKEWTDN---NAIVIEKPEQVNDIEISN--KTAVVAQTT 175 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 L + +++++ + R P + + IC AT RQ A + LA Q +V++VVG NSSN+ Sbjct: 176 LREEKFNEIVEKILDRNPNTI--VHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNT 233 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +L ELA + G + I+ AK+++ +W K +GVTAGAS PD ++ VV ++++ Sbjct: 234 KKLKELAVKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREF 290 >UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; SSU ribosomal protein S1P n=2 Tax=Bacteria RepID=C1SLB2_9BACT Length = 848 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 78/284 (27%), Positives = 144/284 (50%), Gaps = 8/284 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +A+ GFC GV+RA+S+VE+ + +Y ++HN +V E G Sbjct: 6 VEIFIADHAGFCFGVERAVSLVEDTSKQFTG-VYTLGPIIHNPQIVSKFAENGIGVCYNP 64 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV + ++ +HGV++ SR + V DATCP V K + G ++ G Sbjct: 65 EEVNEDNTVVVRSHGVTKETYATLASRKVNVVDATCPFVKKAQNSAKKLGNEGAVVVVYG 124 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ + + +V + L +E + + QTT + + + + Sbjct: 125 EKNHPEVKSIVSFI---DSRYVIVSDVGEASVL--PDENCYALVAQTTQNSESFDKIAEI 179 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + K++ K+ IC AT+ RQ + LA++ ++++V+G +NS N+ RL E+ + + Sbjct: 180 LKTKCDKLI--IKNTICNATSLRQASAIDLAKKVDIMVVIGGRNSGNTTRLYEICKNICA 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 I+ +++++E + VG+TAGAS P LV+ V+ L++ Sbjct: 238 NTHHIETKEELKKEIFDGCRKVGITAGASTPGYLVEEVIEFLKE 281 >UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D7I4_9ACTN Length = 282 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 92/289 (31%), Positives = 141/289 (48%), Gaps = 9/289 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A G C GV+RA+ +VE I+ ++HN VV L +G I Sbjct: 1 MHIRIATEAGACYGVNRALDMVEALSHKIHGRIHTLGPLIHNPQVVSKLAAKGVEVIHNA 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G ++ HGV+ +A V DATCP V + H ++ G + ++ G Sbjct: 61 DEV-SGKAILLRTHGVTPEEEKKAYQSHDIVVDATCPFVIRAHRAAETLTKEGYQVLVFG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GH EVEGT+G G VE+P+D+ L++K ++ + QTT S +++ A Sbjct: 120 EKGHAEVEGTLGHAP----GAVCVETPEDIEALSIK--RRVGIVVQTTQSRRRLKEIVAA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +I D IC AT+ RQ A LA+ + ++V+G K S+N+ RLAE+ + Sbjct: 174 LVGKAEEI--RLFDTICEATSLRQNAATDLAKSVDCMIVIGGKISANTTRLAEICRTYCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 + I+ A+++ W VG+TAGAS P + V RL L Sbjct: 232 HVYHIETAEELDPAWFSPTSEVGITAGASTPQYQIDEVYKRLMSLYPAS 280 >UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5G9_THEAS Length = 280 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 92/285 (32%), Positives = 150/285 (52%), Gaps = 5/285 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L+A+P G C GV RAI +E L G +Y +HN V+ L+ +G + +++I Sbjct: 1 MKVLVASPTGLCFGVRRAIEALEATLEERGR-VYSLGSPIHNPQEVERLKAKGLVVVDEI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP G L AHGVS V EA R V D TCP V K S G +++G Sbjct: 60 DQVPPGVTLFIRAHGVSPQVFREALRRCGEVIDGTCPFVRKAQERAMVLSDEGYPVLIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G + + ++V L +K+ ++QTT ++ DV+ A Sbjct: 120 DGEHPEVKGILGFVNGFAAVVPHRGRLEEV--LDGHRFQKVGVLSQTTQKLEVFFDVVKA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L P++ + IC AT RQ AV LA + ++V+G +NS+N+ +L ++A G Sbjct: 178 LVGIVPEV--RVYNTICSATLERQRAVCELASSVQGIVVMGGRNSANTRKLYQIALESGA 235 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +A I+ ++ W+ + +G+ AG S PD L++ ++ RL++L Sbjct: 236 QAVWIEHPDELDYGWLADKGSIGLAAGGSTPDWLIRELIERLEKL 280 >UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Anaeromyxobacter RepID=ISPH_ANADF Length = 283 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 85/286 (29%), Positives = 141/286 (49%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV R + V P+ ++HN V RE+G ++ + Sbjct: 1 MEVKIAKTAGFCWGVRRTVDKVMEVADHASGPVVTLGPIIHNPQAVARFREKGVGTVDAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV DG ++ HG + + A+ R L V D TCP V R S G +++G Sbjct: 61 GEVGDGTTVVVRTHGAVKEELDRAEGRGLEVVDGTCPYVKYPQAIAQRLSAEGYHVVIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A H E++G + EG +V+ + ++ +K++ + QTT D V+ A Sbjct: 121 DANHAEIKGVISY---SEGPCTVVKPGGPIPEIP---AKKVAVIAQTTCIGADFEAVVGA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R ++ + IC T RQ R+LA + + V+VVG KNS+N+ LAE+ + + Sbjct: 175 LALRHKEV--RAVNTICNDTEERQADARSLAREVDAVVVVGGKNSANTRHLAEICREIQP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 R + ++ +++ EW + VG++AGAS PD +V+ V L+ L Sbjct: 233 RTWHVETEAELRPEWFTGCQVVGLSAGASTPDWVVEGVAGWLRGLH 278 >UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonellaceae RepID=D2RKJ8_ACIFE Length = 680 Score = 333 bits (854), Expect = 5e-90, Method: Composition-based stats. Identities = 93/285 (32%), Positives = 153/285 (53%), Gaps = 6/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A+P GFC GV RAI++ E Y I E+VHN VV+ L+++G E++ Sbjct: 1 MKIYVADPCGFCYGVKRAINVAEVQAKGYNDSIATLGELVHNPRVVEKLKQQGVECKEKL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G +IF +HGV A+ EA+ R+L V DATCP V K A + G I++G Sbjct: 61 AQFAAGDTVIFRSHGVGPALYEEARQRELNVIDATCPHVRKAQKTAAELAGEGRFVIIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ + ++E+ DD+ L K+ K ++QTT + + ++ Sbjct: 121 EKRHPEVQSIKAWAGSDS---VVIETSDDLGSLPEKD--KFGVVSQTTFEAEKFNLLLRM 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +++ P + IC AT RQ A R LA + + V G KNS+N+ L ELA+ + Sbjct: 176 AQEKRPGDYKVVR-TICTATAERQAAARQLAGKTDAFFVFGGKNSANTRHLWELAREINP 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++L+ DA +I + + +G+TAGAS P +++ + ++ + Sbjct: 235 RSYLLQDASEITGPMLAGAQKIGITAGASTPQEIIEEAIGTMETM 279 >UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GLE4_9DELT Length = 297 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 81/285 (28%), Positives = 142/285 (49%), Gaps = 5/285 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 Q+LLA GFC GV A+ ++ AL I+ ++HN V++ +G I+ Sbjct: 4 QVLLAESAGFCMGVSLALGKLDKALENQTSQRIFTYGPIIHNPQVLEYYHGKGVKIIDNW 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G +++ AHGV V + + +++ + DATCP V K + + + S + ++ G Sbjct: 64 DEPRPGDMVLIRAHGVPLQVEEKLREKNIDILDATCPKVKKAQLLIYKNSAVSDRLLIYG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G + + +L E+ + K+ + +++ ++QTT + + Sbjct: 124 ELDHPEVKGLLSYA---QCEAFLFENMQEFKKIALAPKDRYCLVSQTTQDRQEFLSIASE 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ D IC AT +RQ +A Q E + VVG +NS N+ RL ++A++ Sbjct: 181 LK-HSQGNEIITLDTICDATKDRQNETIKIAGQVECMFVVGGRNSGNTRRLYQVARKYCP 239 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R I+ ++I E VK VG+TAGAS P+ +Q++ L ++ Sbjct: 240 RCLHIETKEEIDPEMVKGCSKVGLTAGASTPNSTIQSIYQYLHRI 284 >UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GDV0_9FIRM Length = 678 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 96/300 (32%), Positives = 163/300 (54%), Gaps = 6/300 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A GFC GV +A+ +A +Y + HN ++D LRE G IF++ + Sbjct: 1 MKVIVAEHAGFCGGVKKAVKQALDASRQ--GRVYALGPLAHNDSLLDKLREEGVIFVDDL 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +EVP GA ++ +HG V +A+ R L + DATC V K+ VAR G++ I++G Sbjct: 59 AEVPHGATVVIRSHGERPEVFRQAEERGLQIVDATCTFVGKLQTLVARLIEEGKQVIVLG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE++G +G + + S ++ L E+ ++ + QTT +++ + Sbjct: 119 DPTHPEIKGVLGWGRDQPIVLTADGSISELEGLN--REKPVALVAQTTQRQSILAEIGEK 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ P V + IC AT RQEA R LA ++++VVG KNS+N+ +LA++ + G Sbjct: 177 LKAIVP--VVEIYNTICQATALRQEAARNLAYDVDLMVVVGGKNSANTRKLADVCRSTGV 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 R + +A ++ E +KEV+ VGVTAGAS PD ++ V+ +++ E + E + Sbjct: 235 RTIAVSEAHELDAEQLKEVRTVGVTAGASTPDWTIKEVIGKMENEKNTELQEEQTATEEV 294 >UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=51 Tax=Epsilonproteobacteria RepID=ISPH_CAMFF Length = 279 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 91/286 (31%), Positives = 159/286 (55%), Gaps = 13/286 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRER-GAIFIEQ 59 M+I LA GFC GV RAI I EN+ E++HN +D L+ ++ Sbjct: 1 MKIELAKSYGFCFGVKRAIKIAENSKNAS-----TIGELIHNSLEIDRLKNNFNVKTLKD 55 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 ISE+ + I HG+++ KSRD+ + DATCP VTK V + S G E + Sbjct: 56 ISELKNEKKAIIRTHGITKEGLANLKSRDVEIIDATCPFVTKPQQIVEKMSSEGYEIVFF 115 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G M S +Y++ ++ + + + K++ ++QTT ++ + ++ Sbjct: 116 GDINHPEVKGVMSYSSK---NVYVILDESELETVKLPS--KIAVVSQTTKKIEKFTKIVS 170 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L +R ++ + IC AT QEAVR L+ +A+V++++G KNSSN+ +L +++ + Sbjct: 171 YLMQRVKEV--RVFNTICNATLENQEAVRELSSRADVMVIIGGKNSSNTKQLYLISKNLC 228 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++LI+ +++ +W + K G++AGAS P+ ++QNV+ +L+ L Sbjct: 229 PDSYLIESENELELKWFQNKKLCGISAGASTPEWVIQNVINKLENL 274 >UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=36 Tax=Clostridium RepID=ISPH_CLOPS Length = 282 Score = 330 bits (846), Expect = 6e-89, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 161/288 (55%), Gaps = 13/288 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE--Q 59 ++LA GFC GV RA+ +G IY ++HN VV+ L + IE Sbjct: 4 NVILAKNAGFCFGVKRAVDEAIKYQKEFGKKIYTLGPLIHNNDVVNYLEDNDIFAIELSD 63 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + G +++ +HGV ++V + + L V +ATCP VT + ++V + +G + I++ Sbjct: 64 TNSLNKGDVVLIRSHGVKESVIKDLTDKGLIVKNATCPYVTNIQLKVKKCYEQGYKIIIV 123 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G ++ + ++ + K+ ++QTT + + V++ Sbjct: 124 GDENHPEVIGINGWCND---SAIITNGKTELENIPA----KVCVVSQTTEKKETWNKVLN 176 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K +IV + IC AT RQ++V+ L+++A++V V+G KNSSN+ +L E+ ++ Sbjct: 177 EIVKESKEIVA--FNTICSATDVRQKSVQELSKEADLVFVIGGKNSSNTTKLYEICKKEC 234 Query: 240 KRAFLIDDAKDIQEEWVKE--VKCVGVTAGASAPDILVQNVVARLQQL 285 +++ I++ K++ E +++ VK +G+TAGAS PD ++ V++++++L Sbjct: 235 PKSYHIENVKELDESLLEDESVKTIGITAGASTPDWIINEVISKIKEL 282 >UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Leptospirillum RepID=A3ERP9_9BACT Length = 302 Score = 329 bits (844), Expect = 9e-89, Method: Composition-based stats. Identities = 99/285 (34%), Positives = 163/285 (57%), Gaps = 7/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I L G C GV RAI + P+++ HE+VHN +VV L ERG ++++ Sbjct: 1 MDIFLPEYAGVCVGVKRAIKMAHKTAEEATGPVFILHEIVHNTHVVKDLSERGVKSVDEV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G LI SAHGV+ V +A+SR+L V D TCPLV K+H V + + L+G Sbjct: 61 KEVDKG-TLIISAHGVAPEVIADARSRNLEVVDTTCPLVWKIHRIVKALAEKNYTIFLLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G + +++ +++ L + E ++ ++QTT S+ +++D Sbjct: 120 ERNHDEVMGVQGVAKD---HIHIFHKKEEIAHLPL-TEGPVALVSQTTQSIKYFDEILDL 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L +R+P++ + IC AT RQ + A+A +V++ VGS +S+NS RL E++ + + Sbjct: 176 LLERYPQLE--IHNTICDATEKRQTSALAIAGDMDVMITVGSMSSANSRRLQEVSAGLCR 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++L+D A ++ + W K + VGVTAGAS P+ L++ V+ +L ++ Sbjct: 234 ASYLVDSANEVSDTWFKGGERVGVTAGASTPEWLIEGVIEKLMEI 278 >UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=D1CF50_THET1 Length = 293 Score = 328 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 93/297 (31%), Positives = 143/297 (48%), Gaps = 12/297 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ+ LA GFC GV + + + + + + +VHN VV L+ RG + Sbjct: 1 MQVKLARELGFCFGVKKTLKL-FDEMGSDSRGVKTLGTLVHNPQVVSELKARGVGVAYSV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G L +AHG EA+ + L + D TCPLVTKV + G + ++ G Sbjct: 60 DEVDSG-TLTITAHGAGPDAYAEAQRKGLRLLDTTCPLVTKVQKIAESLHKDGYQVVVYG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTV------KNEEKLSFMTQTTLSVDDT 174 H EV G +G N + ++ + V +L + +KL+ ++QTT + Sbjct: 119 DPNHQEVRGIVGWTENT--ALVSTDAKELVPRLKALTSSKKRVPKKLAVVSQTTQPAERF 176 Query: 175 SDVIDALRKRFPKI--VGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 I L P + IC T +RQ AV LA + +V++VVG ++S+N+ LA Sbjct: 177 KSFIAELVSLLPDDFNEFHVHNTICQPTLDRQSAVVELANEVDVMVVVGGRDSANTKHLA 236 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 ELA G + I+ ++I W K K VGVTAGAS PD +++ VV ++ + E Sbjct: 237 ELASEEGVPTYHIEWPEEIDPNWFKGAKVVGVTAGASTPDAVIEKVVKTIEAIEPEE 293 >UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collinsella RepID=B6GBX2_9ACTN Length = 283 Score = 328 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 98/285 (34%), Positives = 152/285 (53%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + I +A G C GV+RA+++ A P+ ++HN VV L G +++ Sbjct: 3 LTIEVARHAGVCYGVERALTLAAEAARESRGPVRTLGPLIHNPLVVSELEHAGVTVADRV 62 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G +I AHGV V + A+ LTV DATCP V KVHM + R G + I++G Sbjct: 63 EEVDAG-TVIIRAHGVVPQVVDRAERLGLTVLDATCPYVKKVHMAAEKLVREGYQLIVVG 121 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 +GHPEVEG MG + +V +P D+ + + K+ + QTT +V S ++ A Sbjct: 122 ESGHPEVEGIMGHA---DERARVVSTPADLDAIELS--RKVGVVVQTTQTVGALSSIVSA 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R ++ + IC AT RQ++ LA + +V++VVG KNS N+ RLA++ Q Sbjct: 177 LLSRTSELRVI--NTICAATQERQDSAAELAARVDVMIVVGGKNSGNTRRLAQICQMGCA 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 I+D+ +++ W V+ +GVTAGAS P + V +++ L Sbjct: 235 HTHHIEDSSELEASWFTGVEHIGVTAGASTPAAHIDRAVEKIRAL 279 >UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N521_SLAHD Length = 276 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 94/285 (32%), Positives = 145/285 (50%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL A G C GV+RA+ +V A + ++HN VV L RG ++ Sbjct: 1 MEILRAKHAGVCYGVERALDMVSAASMDGDEDTFTLGPLIHNPQVVAKLESRGVRAVDGP 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +V G I+I HGV + + KSRDLTV DATCP V K A + ++IG Sbjct: 61 EQVDHG-IVILRTHGVEPHIAADLKSRDLTVIDATCPHVAKAQRSAANLADTCGTVLIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPE+ +V DV ++ EE + + QTT S + V++ Sbjct: 120 RAEHPEIRSVREYAG---EKAIVV---ADVDEVPEHLEEPVGVIVQTTESKEKLQAVVNE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R + K+ IC+AT RQ+A ALA++ + ++V+G KNSSN+ L E+ + Sbjct: 174 LEAR--GVETQVKNTICFATRQRQDAAAALADEVDAMVVIGGKNSSNTTHLYEICRDHCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++ ++ +++ W VGVTAGAS PD +++V++ L+ L Sbjct: 232 RSYFVETKEELDPSWFSATDRVGVTAGASTPDYQIEDVISYLESL 276 >UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AXA2_SYNWW Length = 687 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 102/306 (33%), Positives = 157/306 (51%), Gaps = 15/306 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M +LLA GFCAGV +A+ I E A + +VHN VV+ R++G ++ + Sbjct: 1 MYVLLARNAGFCAGVRKAVKIAEEAAEEPDK-WFSLGPLVHNDEVVNYFRQKGIEPVDML 59 Query: 61 SEVPDG-AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + A +I +HG S V +A+ L V DATC LV K+H V R + ++ Sbjct: 60 ERIGEQPAGIIIRSHGTSPEVIKQAQELGLEVRDATCVLVKKIHEIVTRLRGEDYDIVVF 119 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G A HPEVEG +G +V S D+V L V K++ ++QTT + V Sbjct: 120 GDARHPEVEGILGWCGQ---RASVVASADEVGYLPVMP--KVALISQTTRDEKEFQKVAG 174 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 AL + ++ + IC AT +RQEA R L + +++LV+G SSN+ L++ Q G Sbjct: 175 ALSNKCREL--KVFNTICSATRSRQEAARELCRKVDLMLVIGDLKSSNTRTLSKECQNTG 232 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL------QQLGGGEAIPL 293 R F I A +I+ EW+ V +G+TAGAS PD +++ V+ R+ + L + Sbjct: 233 VRTFQIQKASEIKPEWLDGVSKIGITAGASTPDWIIKEVLDRMTLYEEEKMLDENQETNQ 292 Query: 294 EGREEN 299 E +E Sbjct: 293 ETSQET 298 >UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C7MNA7_CRYCD Length = 284 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 92/291 (31%), Positives = 146/291 (50%), Gaps = 7/291 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A+ G C GV RA+++ + A A G + ++HN VV L G + + Sbjct: 1 MEIIIASRAGACYGVQRALNLAQKA-AQSGGDVQTLGSLIHNPQVVAELAASGVEAVSKP 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ + I +HGV+ VR + + DATCP V + + G I++G Sbjct: 60 EELTA-SRAIIRSHGVTPQVREGIEQAGADIIDATCPHVLRAQQAARDLALEGRLVIVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEVEG G + + +PDDV + + + + QTT + +ID Sbjct: 119 EESHPEVEGLRAWAEQAGGQVVVAATPDDV---PSQIDGSVGIVVQTTQRREKLDAIIDV 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R I +D IC AT+ RQEA LA Q +V++V+G NSSN+ RL E+ + Sbjct: 176 LKSR--GIEAEIRDTICSATSTRQEAAAELASQVDVMVVIGGHNSSNTTRLFEICRARSP 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +AF I+ ++Q K + VGVTAGAS P+ +++V+ RL+ + Sbjct: 234 QAFHIESPDELQAIDFKGAQRVGVTAGASTPEDQIESVIERLRSFAESQEE 284 >UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/ribosomal protein S1 n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMR5_9FIRM Length = 658 Score = 325 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I A GFC GV +A+ I ENA + ++HN VV L +G + Sbjct: 17 MKIYKARVMGFCYGVRKAMEIAENAAVSGQKTV-TLGPIIHNPQVVARLAGKGISPVMST 75 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ D +I +HG+ + N K + + DATCP V + + G++ +L+G Sbjct: 76 DEITD-ETVIIRSHGIGPSCYNNLKRKKSVLLDATCPFVKRNQEIAKGLAAEGKKIVLVG 134 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE+ Y+VE+ +DV L + +++ + QTT S+ +I A Sbjct: 135 EKKHPEMLSVAEWAGEAP---YIVETMEDVEAL--PDLDEVHIVIQTTFSLSLADRLITA 189 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++++ + IC AT++RQ A LA +V++V+G +NS+N+ RL E+ Q G Sbjct: 190 IKRKAGSV--SVHKTICNATSDRQTAAGELARNVDVMIVIGGRNSANTGRLVEVCQAEGA 247 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 I+ A ++++EW VG+TAGAS PD +++ V ++ + Sbjct: 248 VTHHIETAAELKKEWFHSQCKVGITAGASTPDWIIEEVFFIMEDMN 293 >UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=8 Tax=Bacteria RepID=D1PP74_9FIRM Length = 639 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 89/286 (31%), Positives = 151/286 (52%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++ A GFC GVDRA+ + + L G + ++HN VV L +GA+ + + Sbjct: 1 MKVIRAKTAGFCFGVDRAVKLTYDLL-GQGRRVATLGPLIHNPQVVQDLEAKGALTCDGV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VPDG +I +HGV Q V + +R L DATCP V K+H A A ++G ++ G Sbjct: 60 EDVPDGYEVIIRSHGVPQNVYEKISTRGLAYHDATCPFVAKIHKLAAEAGKKGALLLVAG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVDDTSDVI 178 A HPEV+G +G + P + + +++ L + +E + + QTT V+ Sbjct: 120 DANHPEVQGIVGHATGP---VRVFADLEELQNLLPELLQQESIHVVAQTTFRVESWESCK 176 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 L+K K D IC AT RQ+ L+++ + ++V+G +SSN+ +L ++A R Sbjct: 177 AFLKKECTKAE--IFDTICNATWARQQEAEDLSQKCDRMVVIGGHHSSNTQKLLQVAARH 234 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 A ++ A ++ W+ + VGVTAGAS P +++ V+ + + Sbjct: 235 -TTAINVETADELDPAWLAGAETVGVTAGASTPSSIIEEVLNSMSE 279 >UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBE4_ELUMP Length = 564 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 85/283 (30%), Positives = 147/283 (51%), Gaps = 8/283 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + +A GFC GV +AI V + PI+ ++HN V+ +L E+G I SE Sbjct: 8 VTIAKSAGFCPGVKKAIDKVLELESSGKKPIFTLGPLIHNNQVIATLEEKGITSIGHPSE 67 Query: 63 VP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 V +L+ AHG++ + E +S V DATCPLV VH +++ + G ++++G Sbjct: 68 VEGKEGVLVIRAHGITPEFQREVESCGKEVIDATCPLVKHVHNNISKYAGEGYTTVIVGD 127 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EV G +G +G Y+V +V L + + +K++ + QTT + + + Sbjct: 128 AGHAEVIGLLGY---TQGRGYVVADESEV--LALPDFDKVNIVAQTTQKEAAFYKLAELI 182 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +++ + V + IC T RQ A+ A+ V+VVG KNS+N+ RLA+L + + Sbjct: 183 KQKAKEAV--VSNTICEPTKQRQSETIEYAKNADFVIVVGGKNSANTARLAKLCGELAPK 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 ++ D++ +K K + +TAGAS P+ L+ + ++ Sbjct: 241 VLHVETEADLEGHDLKTPKKIFITAGASTPNWLIDRISGAVKN 283 >UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMG2_9BACT Length = 275 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 80/282 (28%), Positives = 136/282 (48%), Gaps = 8/282 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A P G C GV RAI +E AL G ++ +HN V L ++G + +E Sbjct: 1 MKVVVAEPTGLCFGVKRAIRTMEEALEEKGR-VFCIGSPIHNPQEVQRLVDKGLVVVEDD 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P + AHG+S V + + + D TCP V K R SR G +++G Sbjct: 60 DRIPPDEPVFVRAHGISPDVHQRLQDKGARIIDGTCPFVRKAQEMAGRLSREGYYLVVLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE++G +G P +V D+ + ++ + +QTT +++ Sbjct: 120 DENHPEIKGILGYVEGPY---LVVSGKKDLRAIDKIDKIGII--SQTTQQESTLKELVSE 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +I + IC AT RQEAVR LA + + ++++G NS+N+ +L +AQ G Sbjct: 175 AVGSAREI--KVSNTICRATVERQEAVRRLAYKVDGIVIIGGHNSANTGKLFRIAQESGT 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 A ++ A + W+ +G+ AGAS PD L++ + + Sbjct: 233 PALWVEQADQLDGRWLSGKGTIGIAAGASTPDWLIKQLQQAM 274 >UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Alphaproteobacteria RepID=C9D092_9RHOB Length = 556 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 134/228 (58%), Positives = 179/228 (78%), Gaps = 2/228 (0%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + LA PRGFCAGVDRAI IVE AL +GAP+YVRHE+VHN++VVD LR++GA+F+E++ E Sbjct: 9 LYLAAPRGFCAGVDRAIKIVEMALEKWGAPVYVRHEIVHNKFVVDGLRDKGAVFVEELEE 68 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 PD +IFSAHGV ++V A++R++ DATCPLV+KVH+E R + G + I+IGH Sbjct: 69 CPDDRPVIFSAHGVPKSVPAAAQAREMVFVDATCPLVSKVHIEAQRHAEAGLQMIMIGHK 128 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 GHPE GTMGQ PEG + LVE+ +DV + V++ E+L+F+TQTTLSVDDT D++ AL+ Sbjct: 129 GHPETIGTMGQL--PEGEVLLVETVEDVAHVDVRDPERLAFVTQTTLSVDDTKDIVAALQ 186 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 RFP I+GP K+DICYATTNRQEAV+ +A +++ +LVVG+ NSSNS R Sbjct: 187 TRFPAIIGPHKEDICYATTNRQEAVKEVAPKSDALLVVGAPNSSNSRR 234 >UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYQ1_UNCTG Length = 300 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 84/303 (27%), Positives = 156/303 (51%), Gaps = 16/303 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +++ +A GFC GV RAI + E +Y V+HN V L ++G ++ Sbjct: 7 LRVKIAENAGFCFGVRRAIDLTEKTAGKE-RKVYTLGPVIHNPQEVKRLEKKGIKTLKDP 65 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKS-RDLTVFDATCPLVTKVHMEVARAS----RRGEE 115 +V G+ +I HG+ + + + +++ V DA CP V + + R S + + Sbjct: 66 KKVKSGS-IILRTHGIPCNLHKKLEENKNINVIDAACPFVKRAQNTIKRLSTDIKSKDKT 124 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 I++G HPEV + S G +VE+ + K + + L+ ++QTT + ++ + Sbjct: 125 IIVVGEKIHPEVIALVSYGS---GKCIIVENIKEAQKFRGRGD--LNIVSQTTQTPENFN 179 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 +I L+KR+ + IC AT +RQ+A LA+ ++++V+G KNS N+ RLA++ Sbjct: 180 SIIKVLKKRYK---TKVYNTICKATLDRQKAAEKLAKNVDLMIVIGGKNSGNTTRLAQIC 236 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG 295 + + I+ A I+E+W K + VG+TAGAS PD +++ + R++++G + Sbjct: 237 SEK-TKTYHIETACSIKEKWFKNINSVGLTAGASTPDWIIKEIEMRIKEVGAKHYLEFIS 295 Query: 296 REE 298 + Sbjct: 296 AAD 298 >UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Brachyspira hyodysenteriae WA1 RepID=C0R0R2_BRAHW Length = 581 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 82/289 (28%), Positives = 139/289 (48%), Gaps = 8/289 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + + GFC GV A+ + + + IY+ ++HN +D L G E Sbjct: 1 MNVDIGKFAGFCDGVKYAVENTFSQASKKNSDIYIDGHLIHNPQTLDMLENIGVKTYEDD 60 Query: 61 SE--VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + V DG +I AHG+S R S + + TC V K+ V + S G I+ Sbjct: 61 EDMSVLDGKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKYSSLGYRVIV 120 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IG+ HPE+ G G + +Y+V +D+ KL + +K + QTTL + Sbjct: 121 IGNPVHPEIVGVCGYADD----VYVVYKDEDLNKLP-NDSKKALIVAQTTLQKSAFDKFV 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 ++ ++ K+ IC AT RQ V +A++ +VVLV+G SSN+ L +A + Sbjct: 176 AQIQDKYKDTEIIIKNTICAATEQRQNEVLEIAKRNDVVLVIGGSESSNTRNLYNIASSI 235 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K AF ++ +D+++ + K +G+ AGAS PD L++++ ++ Sbjct: 236 -KPAFYVEYKEDLEKIDLSNYKNIGIMAGASTPDWLIEDIAQTIKDKYA 283 >UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Opitutus terrae PB90-1 RepID=ISPH_OPITP Length = 289 Score = 318 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 91/296 (30%), Positives = 157/296 (53%), Gaps = 18/296 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L A GFC GV+RAI I + P+Y ++HNR +++ L E G + Sbjct: 1 MKVLRAKSAGFCWGVERAIEITRDYAHQGRKPVYTDGPLIHNRQMMEKLSEEGIREVGDY 60 Query: 61 SE----------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 + +++ AHG+S RN KS + DATCP V + ++ + Sbjct: 61 QSRANIAVNPAAPGENPVMVVRAHGISPERRNYLKSLGMDFKDATCPDVGIIAGKIRLHA 120 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLS 170 ++G +I+ G HPE G +G EG Y + S D+ L E++ ++Q+T+ Sbjct: 121 KKGYATIIFGDKNHPEAIGLLGY---TEGRGYCITSKADIDALPA--LERVCMVSQSTMF 175 Query: 171 VDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSN 229 + + +++ + R++F +++ D IC AT +RQ V ALA Q A+ ++V+G +S+N+ Sbjct: 176 MHEFAELSEYARQKFKEVL--VFDTICQATKDRQTDVVALARQGAQAIVVIGGHHSANTV 233 Query: 230 RLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +LA LA+ + I+ A ++ E +K+ +GVTAGAS P+ L+ V A+L+ L Sbjct: 234 KLASLARLQNLPTYHIETAAELSPEEMKKFTVIGVTAGASTPEFLISEVCAKLEAL 289 >UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1C7U3_9FIRM Length = 666 Score = 318 bits (816), Expect = 1e-85, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 154/301 (51%), Gaps = 11/301 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I A G+C GV++A++ A +Y ++HN +V + L+E+G I+ + Sbjct: 1 MNIRKAKSAGYCFGVNKAVNTAYEASENSNEKVYTLGPLIHNVHVTNELKEKGVSIIDNL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ +G +I +HGV + + + K ++L + DATCP V + +V + +G I++G Sbjct: 61 DDIDEG-TVIIRSHGVGKEIYEKIKKKNLKLIDATCPYVKSIQNKVEKYHNKGYTIIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 + HPEV+G G N ++ + ++ K +E + + QTT+ D+ + Sbjct: 120 DSDHPEVKGVNGWCENKAK---VIFTKEEAKN--FKTDENVCVVAQTTIIEALFDDITNI 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++ +V + IC AT+ RQE +A + E ++VVG +SSN+ +L E+++ Sbjct: 175 IKDNCANVV--IFNTICNATSVRQEEASLIASEVEAMVVVGDTHSSNTKKLVEISKSKCD 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 F ++ A D+ + +K+ +G+TAGAS P L++ V+ + + EE+I Sbjct: 233 NVFFVETASDLDDA-IKKYNNIGLTAGASTPTQLIEEVINTMDNNMVDSFE--KNIEESI 289 Query: 301 V 301 Sbjct: 290 K 290 >UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LQM8_DESBD Length = 286 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALA---IYGAPIYVRHEVVHNRYVVDSLRERGAIFI 57 M++++A GFC GVD A+ ++NA++ IY ++HN V+ + G + Sbjct: 1 MELIIAETAGFCMGVDMALHKLDNAVSIPPQDAQHIYTLGPIIHNPQVLARYKGLGVLQT 60 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + + G +++ AHG+ + ++ + +++TV DATCP V K + + R + + + + Sbjct: 61 DGTKPLQTGDVVVIRAHGIPRHIQTSLEGQNITVVDATCPKVKKAQILIQRQADQNKHLL 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 L G HPEV+G + + ES +++ V + QTT + + Sbjct: 121 LFGERDHPEVQGLVSYAP----KHTIFESLEELQAYEVDPAQTYFLAAQTTQDRESFDTI 176 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + LR + D IC AT +RQE VR L+ + + +++VG KNS N+ RLA++AQ Sbjct: 177 REYLRANVDAAMT-ILDTICMATKDRQEEVRELSRKVQAIVIVGGKNSGNTRRLAQIAQE 235 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 G A ++ A+++ E + +G+TAGAS P ++QNV L+ Sbjct: 236 SGIFAIHVETAEELPLEELAAFTRIGLTAGASTPPWIIQNVAQTLR 281 >UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Dehalococcoides RepID=ISPH_DEHSC Length = 284 Score = 317 bits (813), Expect = 3e-85, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 143/290 (49%), Gaps = 9/290 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ A+ GFC GV RAI+I+E + G + +VHN+ V++ L G ++ I Sbjct: 1 MKVECASNIGFCFGVRRAINILEKTASERGG-VETLGALVHNQQVLNRLSGMGVRVVKNI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G + S+HGV AV E KS+ L + D TCP V + + R G +++ G Sbjct: 60 DDI-SGRTVAISSHGVGPAVLAELKSKGLEIVDTTCPFVKRAQVAAKRFHDAGFFTVIYG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G + DD+ L+ + ++QTT + + Sbjct: 119 DVNHPEVKGILGWAGGNGLATLNPQGLDDIPDLS----RYIGVLSQTTQIPTGFTSFVKN 174 Query: 181 L--RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + D +C+ +RQ A LA + +++LV+G NS+N+ L +L + + Sbjct: 175 VIDQALVKDAEIRIADTLCHDIRDRQAAALELAGRVDLMLVIGGHNSANTRHLLDLCKTV 234 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 LI+ A ++Q +W+K V +G+T+GAS + + V + L +L G Sbjct: 235 -SNTHLIETASELQTDWLKGVSRIGITSGASTDETTISEVCSYLDRLSAG 283 >UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Thermomicrobia (class) RepID=B9L0U3_THERP Length = 327 Score = 316 bits (810), Expect = 7e-85, Method: Composition-based stats. Identities = 94/298 (31%), Positives = 140/298 (46%), Gaps = 15/298 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I++A GFC GV RA+ IV NA P+ +++HN VV+ L G + + Sbjct: 16 EIVVAEVLGFCWGVRRALEIVRNAARE--RPVAALGDIIHNPIVVEQLTREGVLPVTDPV 73 Query: 62 EVPDG--AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 E + +AHG EA DL V D TCPLVTKV + + +G ++ Sbjct: 74 EAKRHGLDRVAITAHGAPPTRYQEASVYDLEVIDTTCPLVTKVQRLAQKLALQGYFLVVY 133 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVW-------KLTVKNEEKLSFMTQTTLSVD 172 G A HPEV G +G +S DD+ K++ + QTT D Sbjct: 134 GDAQHPEVRGVLGWAGTERACAA--KSFDDLPWDGPRGTGAMQPPPRKVALIAQTTKRTD 191 Query: 173 DTSDVIDALRKRFPKIVGP--RKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 + + AL G + IC T RQEA+ LA ++VLV+G + SSNS R Sbjct: 192 EFTAFAQALAAWVLPHGGELRVVNTICQPTWERQEALARLARTVDLVLVIGGRKSSNSAR 251 Query: 231 LAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 L E+++ +G + L++ + V+ VG+TAGAS PD ++ V+ L +LG Sbjct: 252 LVEVSRSLGTPSVLVERPDQLDPALFAPVRRVGITAGASTPDEVILAVIEELVRLGFA 309 >UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZW7_ACIFD Length = 344 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 119/309 (38%), Positives = 180/309 (58%), Gaps = 10/309 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRGFCAGV+RAI + L I+ P+Y HE+VHNR VV++ G +F++ + Sbjct: 5 KVLLAAPRGFCAGVERAIGALGWMLRIFEPPVYCYHEIVHNRLVVEAFEAAGVVFVDDVE 64 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 VP G ++ SAHG + V A+ R V DA CPLVTKVH E+ ++RG + + +GH Sbjct: 65 SVPPGRPVMLSAHGTAPEVLEAARQRCPIVVDAVCPLVTKVHHEIRTRAQRGYQIVYVGH 124 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E G + + VE+P++ +T+ + ++ + QTTL+V + + + Sbjct: 125 RGHEEAIGATAEAP---EAVTFVETPEEARAITL-GDGPVALLAQTTLAVPEWEAIAAIV 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK- 240 + P + P + D+CYATTNRQ AVRALAE+ + ++VVGS NSSN+ L +A G Sbjct: 181 ASQTPNLWQPGRSDLCYATTNRQAAVRALAERVDAMVVVGSANSSNTRALERVATSAGVG 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 ++ ++ + VGVTAGASA + +V++VVA L G E I + EE+ Sbjct: 241 HVERVNRPSELVGPF---EGIVGVTAGASAAESVVKDVVAALAPRLGVEEISV--LEEDE 295 Query: 301 VFEVPKELR 309 F +P +LR Sbjct: 296 FFPLPPDLR 304 >UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Brachyspira murdochii DSM 12563 RepID=C1QCD1_9SPIR Length = 583 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 140/300 (46%), Gaps = 10/300 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVEN--ALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M + + GFC GV A+ + A IY+ ++HN +D L G E Sbjct: 1 MNVDIGKFAGFCDGVKYAVENTFSQAAKNNNNDDIYIDGHLIHNPQTLDMLENIGVKTYE 60 Query: 59 QISE--VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + V + +I AHG+S R S + + TC V K+ V + S G Sbjct: 61 DNEDMSVLNNKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKHSSLGYRI 120 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 I+IG+ HPE+ G G ++ +Y+V +D+ L + +K QTTL Sbjct: 121 IVIGNPKHPEIIGVCGYAND----VYVVYKDEDLNNLP-NDTKKTLIAAQTTLQKSVFDK 175 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 +D +++++P K+ IC AT RQ V +A++ + VLV+G SSN+ L +A Sbjct: 176 YVDKIKEKYPDTEIIVKNTICEATEQRQNEVLEIAKRNDAVLVIGGSESSNTRNLYNIAS 235 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 + K AF ++ +D+++ + + K VG+ AGAS PD L+++V ++ R Sbjct: 236 SI-KPAFYVEYKEDLEKIDLSKYKNVGIMAGASTPDWLIEDVAQTIKDKYASPITRFVSR 294 >UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M529_9BACT Length = 289 Score = 313 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 10/286 (3%) Query: 1 MQIL--LANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M + A P G C GV RAI+ +E AL+ G +Y +HN + L ++G + Sbjct: 1 MTVRFSKAEPTGLCFGVKRAIAQMEKALSSDGE-LYCVGSPIHNPQEIARLAQKGLRVVA 59 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +VP G+ + AHG++ +RN K R++ + D TCP V G ++ Sbjct: 60 SPQDVPSGSTVFIRAHGIAPDLRNALKQRNVRIIDGTCPFVRVAQARAKALEDEGYSVVV 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 G A HPEV +G + G +V + D+ L E++ F++QTTL D + ++ Sbjct: 120 AGDASHPEVISIVG---GLQNGAKVVSNSTDLQDLA--KIERIGFVSQTTLPEDLFASIV 174 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 A + P + + IC AT RQ AV L ++ + ++V+G ++S+N+ +L +A+ Sbjct: 175 SAAVRISPDV--KAHNTICRATFERQRAVAELVKRTDGIVVIGGRDSANTAKLFHIAKSC 232 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 G I++A ++ +W VG+ AGAS PD L++ + +Q Sbjct: 233 GADVLWIEEAGELDGKWFTGKTHVGIAAGASTPDWLIEEFIQAARQ 278 >UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CWY2_HALOH Length = 678 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 74/266 (27%), Positives = 130/266 (48%), Gaps = 8/266 (3%) Query: 32 PIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTV 91 P+Y ++HN VV L+E G ++ + + +G ++I +HGV + +A+ + L + Sbjct: 12 PVYTLGPLIHNPQVVKRLKEMGIESLDSLDIIDNG-VIIIRSHGVPPDIIEKARQKGLHI 70 Query: 92 FDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVW 151 DATCP V +G ++I+ G HPEV G G N ++ S ++ Sbjct: 71 IDATCPYVKNAQKYARELVDKGYQTIIFGDRDHPEVIGINGAARNES---IIISSEKEIK 127 Query: 152 KLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALA 211 + + + K+ + QTT S ++ + ++ + IC T RQ++ LA Sbjct: 128 DINLSS--KVGLIAQTTKSPASFQKIVSYILPEVKEL--RIYNTICRTTETRQKSAVDLA 183 Query: 212 EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAP 271 Q + + V+G KNS+N+ RLAEL G + I+ A +I +K +G+TAGAS P Sbjct: 184 RQVDAMFVIGGKNSANTTRLAELCAETGTPTYHIETAGEIDFRQLKSYNKIGITAGASTP 243 Query: 272 DILVQNVVARLQQLGGGEAIPLEGRE 297 D L++ V+ + + + E +E Sbjct: 244 DWLIKEVIEAMSEEKRDAELQEEIQE 269 >UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8 Tax=Clostridiales Family XI. Incertae Sedis RepID=C7RHT6_ANAPD Length = 686 Score = 312 bits (801), Expect = 9e-84, Method: Composition-based stats. Identities = 87/309 (28%), Positives = 161/309 (52%), Gaps = 12/309 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++AN GFC GV R++ + E A+ G Y ++HN +V+ L G +++ Sbjct: 1 MEIIIANYSGFCGGVRRSVELAEEAIKNEGER-YCVGPLIHNPQLVEKLENEGLEVVDKK 59 Query: 61 SEVP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + ++ AHG S + + V DATCP++ ++ ++ G + +++ Sbjct: 60 EALKIKDSTVLIRAHGESADFKERLLANGNEVVDATCPVLNNIYKKIIEKENDGYQVVIV 119 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPE+ +N G+ + D+ +K KL ++QTT +D D+ + Sbjct: 120 GDKTHPEIIAMESFLNN---GIIV---SDETEAKNIKCNNKLYVVSQTTNRLDYFYDIAN 173 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L++ +V + IC AT NRQEA ++LA++ + ++V G NSSN+N+L ++A Sbjct: 174 KLKENNDSVVIE--NTICKATENRQEAAKSLAKEVDCMIVAGGFNSSNTNKLYQVANLYC 231 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 K F I+ KD+ + + + K VG+ AGAS PD +++ VV+ + + + + E++ Sbjct: 232 KNVFRIETVKDLPLQKLSKFKKVGIIAGASTPDEIIEEVVSSMDEF--TKEEFMNSLEDS 289 Query: 300 IVFEVPKEL 308 + PKE+ Sbjct: 290 LKKIYPKEI 298 >UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Firmicutes RepID=ISPH_LISMC Length = 331 Score = 312 bits (800), Expect = 1e-83, Method: Composition-based stats. Identities = 112/325 (34%), Positives = 183/325 (56%), Gaps = 19/325 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M+I+ +PRG+C GV A+ I +NA PI++ +VHN++V D+ G ++ Sbjct: 1 MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVD 60 Query: 59 Q------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + ++ G +IF+AHGVS +V+ +A ++ LT DATCP V + + Sbjct: 61 GANREEILDKITTG-TVIFTAHGVSPSVKAKAAAKGLTTIDATCPDVLHTYNLILEKQAA 119 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G E I IG GHPE EG G + ++LVE+ D+ L++ ++ + QTT+S Sbjct: 120 GYEIIYIGKKGHPEPEGAYGTAPD---VVHLVETKADIDALSLLSDN-IFVTNQTTMSKW 175 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D +D++D ++++FPK + + +IC AT RQEAV A+ A++ +VVG S+N+ RLA Sbjct: 176 DVADLMDYIKEKFPKAI--QHQEICMATQVRQEAVAVQAKGADLTIVVGDPRSNNTARLA 233 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +++ ++ G +A+ I D ++ EW+K+ K V VTAGAS P LV+ V+ L+Q + Sbjct: 234 QVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKT 293 Query: 292 PLEGREENIVFE--VPKELRVDIRE 314 + R N FE +PK + E Sbjct: 294 TWK-RAHNKDFERILPKMKNKYMAE 317 >UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=72 Tax=Bacillales RepID=ISPH_BACC0 Length = 316 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 112/302 (37%), Positives = 166/302 (54%), Gaps = 14/302 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M+I+ +PRG+C GV A+ I NA PIY+ +VHN++V D+ E G I ++ Sbjct: 1 MKIVKISPRGYCYGVVDAMVIARNAALDTSLPRPIYILGMIVHNKHVTDAFEEDGIITLD 60 Query: 59 QISEVP-----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 S + D +IF+AHGVS V+ AK + LT DATCP VTK H + G Sbjct: 61 GPSRLDILDKIDSGTVIFTAHGVSPEVKQRAKEKGLTTIDATCPDVTKTHDLIEAKKAEG 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 I IG HPE EG +G + ++L+E DD+ L + +K+ QTT+S D Sbjct: 121 YHVIYIGKKNHPEPEGAVGIAPD---IVHLIERADDLKTLEIP-TDKILVTNQTTMSQWD 176 Query: 174 TSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +++ ++K+FP +IC AT RQEAV A+ A++ +VVG S+NSNRLA+ Sbjct: 177 VQHLMEDIQKKFP--TAEFHKEICLATQVRQEAVAKQADVADLTIVVGDPKSNNSNRLAQ 234 Query: 234 LAQR-MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 ++Q G +A+ + D +I EW++ V+ V VTAGAS P + + V+A L+Q Sbjct: 235 VSQEIAGTKAYRVADVSEINLEWLQGVENVAVTAGASTPTPITKEVIAFLEQYDPMNPAT 294 Query: 293 LE 294 E Sbjct: 295 WE 296 >UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MRX3_ANATD Length = 663 Score = 310 bits (795), Expect = 4e-83, Method: Composition-based stats. Identities = 98/286 (34%), Positives = 149/286 (52%), Gaps = 7/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVE-NALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV RA+ V A A G I V ++HN YV+D L++ G +E Sbjct: 1 MIIKVAQSAGFCFGVQRAVEGVLAWAKANKGKSIKVYGMLIHNSYVIDKLKDLGVKVVED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I ++ I+ +HGVS E + R V+D TCP V K+H V S G + I++ Sbjct: 61 IEQIGKEDIIFIRSHGVSMEEYAEIEKRADKVYDFTCPYVKKIHEIVMEHSVNGYDIIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G +G N ++V+S + V + + E K + + QTT S++ + Sbjct: 121 GDMNHPEVKGIVGHVGN-NRKCFVVDSIEKVKEAINQIEGKAAVVCQTTFDGKKWSEIRE 179 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L D IC AT NRQ+ + LA+ +++LVVG K SSN+N+L +L + + Sbjct: 180 FLESHTNY---KVFDTICKATINRQKEAQELAQHVDIMLVVGDKKSSNTNKLYKLLKEI- 235 Query: 240 KRAFLIDDAKDIQEEWVKEV-KCVGVTAGASAPDILVQNVVARLQQ 284 K F I+ +D+ + K +GVTAGAS ++ VV L++ Sbjct: 236 KPTFFIEKVEDLDSIKLDSYIKSIGVTAGASTSPEQIEEVVKHLEE 281 >UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=19 Tax=Fusobacterium RepID=ISPH_FUSNN Length = 827 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 84/292 (28%), Positives = 157/292 (53%), Gaps = 13/292 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE-- 58 M+I+ A GFC GV AI++ + + G Y+ +VHN+ VV+ + +G + Sbjct: 1 MEIIRAKHMGFCFGVLEAINVCNSLVEEKGRK-YILGMLVHNKQVVEDMERKGFKLVTED 59 Query: 59 ----QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + E+ + I++ AHG S++V + K R + VFDATC V K+ E+ A+ G Sbjct: 60 ELLNDMDELKEDDIVVIRAHGTSKSVHEKLKERKVKVFDATCIFVNKIRQEIEIANENGY 119 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 + +G HPEV+G + + + + ES ++ KL + ++ TQTTL+ Sbjct: 120 SILFMGDKNHPEVKGVISFADD----IQIFESFEEAKKLKIDLDKTYLLSTQTTLNKKKF 175 Query: 175 SDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 ++ ++ + +V D IC AT RQ+AV LA + EV+++VG SSN+ +L E+ Sbjct: 176 EEIKKYFKENYKNVV--IFDKICGATAVRQKAVEDLAVKVEVMIIVGDTKSSNTKKLYEI 233 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 ++++ ++L+++ + + + + VG+TAGAS P+ + N+ +++ + Sbjct: 234 SKKLNDNSYLVENEEQLDLSIFRGKEVVGITAGASTPEETIMNIEKKVRGIY 285 >UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Dictyoglomus RepID=ISPH_DICT6 Length = 283 Score = 308 bits (790), Expect = 2e-82, Method: Composition-based stats. Identities = 92/290 (31%), Positives = 153/290 (52%), Gaps = 10/290 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + +A P GFC+GV ++IS+ E L+ G +Y +VHN V++ L ++G +E+ Sbjct: 1 MILYIATPYGFCSGVKKSISLAEKVLSNEGE-VYTLGALVHNPKVIEELSKKGIKILEKN 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V +G LI AHG+ Q ++ V+DATCPLV KV + ++ + ++IG Sbjct: 60 GFV-EGKALIVRAHGLPQRDIEFYRTLGNRVYDATCPLVKKVQILAEYLNKNKYKVVIIG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G + + +VE+ DD+ K+ N K+ + QTT S+D+ ++ Sbjct: 119 EKNHPEVIGILSYTDD---QGIVVENEDDIKKIE--NYPKIGIVFQTTQSLDNALQKVNL 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + ++ +I + IC T RQE + L+E ++ LV+G KNS+N+ RL + Sbjct: 174 IMEKGKEI--RIFNTICPETIERQEKAKKLSEMVDLALVLGGKNSANTRRLYITLSKK-I 230 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 + I++ ++I + W KE VG+ G S P+ V+ VV L+ L E Sbjct: 231 PTYHIENIEEIDKSWFKEDNKVGIITGTSTPNDFVEEVVELLKSLYPLEI 280 >UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y3T0_9BACT Length = 293 Score = 307 bits (788), Expect = 2e-82, Method: Composition-based stats. Identities = 95/289 (32%), Positives = 145/289 (50%), Gaps = 6/289 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL+A P G C GV RAI VE ALA AP+Y +HN V+ L++ G ++ Sbjct: 1 MKILVAAPTGLCFGVKRAIGFVEKALAQ-TAPVYALGSPIHNPQEVERLQKMGLRVVQSE 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+P GA + AHG + V + R+++V D TCP V S G +++G Sbjct: 60 TEIPAGATALIRAHGAAPGVLENLRKRNVSVIDGTCPFVRAAQGHARELSEAGYHVLILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVES--PDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 + HPE G G P + + S ++K +VK KL ++QTT +++ Sbjct: 120 NEKHPETVGIRGYVRGPSTVISTIPSLFSSTIFKSSVKIH-KLGLVSQTTQ--EESLLAE 176 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 A + IC AT RQEAVR LA Q E ++V+G NS+N+ +L +A+ Sbjct: 177 AAKAALGVADELRIYNTICRATIERQEAVRRLASQVEGMIVIGGHNSANTGKLCRIARDS 236 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 A I+ A + WV E + +G+ AGAS PD L++ + + + G Sbjct: 237 SCDAVWIEHAGQLDRRWVLEKRVIGIAAGASTPDWLIEQLHNAIHNIAG 285 >UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VSI0_9FIRM Length = 725 Score = 307 bits (787), Expect = 4e-82, Method: Composition-based stats. Identities = 89/292 (30%), Positives = 145/292 (49%), Gaps = 13/292 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RA + A +Y ++VHN V++ L+E+ IE Sbjct: 1 MEIYLADYAGFCGGVKRACKLAFAAADEG---VYCLGDIVHNEVVINDLKEKKVKTIENT 57 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + +I +HGV + + + + + D CP V K++ V + ++G I++G Sbjct: 58 QVY--NSKVIIRSHGVPKEDLEKLRYNNNEIIDCVCPKVKKIYNIVEKYYKKGYNIIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +N + +D+ K + Q+T S + D + Sbjct: 116 DENHPEVKGINSYCNNE---AIIFNKEEDLK----VPVGKTIVVAQST-SNEKVFDYLTN 167 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K K + IC AT NRQ ++R LA+ + V+V+G K SSN+ +LAE+A+ K Sbjct: 168 LIKNISKSEILVYNTICDATFNRQNSIRKLAKIVDAVIVLGGKKSSNTKKLAEVAKESCK 227 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 FLI KDI +K+ +G+TAGAS PD +++ V+ ++ GE + Sbjct: 228 NVFLIQSIKDIDINILKKFNKIGITAGASTPDKVIKEAVSSMENFDKGEMME 279 >UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C8WAL7_ATOPD Length = 284 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 156/288 (54%), Gaps = 9/288 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I +A+ G C GV+RA+ +V+ A+ AP+ ++HN VV SL+++G ++ SE Sbjct: 4 IKIADEAGACYGVERALQMVQQAVKDAHAPVRTLGPLIHNPRVVTSLKDQGVEVVDFASE 63 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 G+ L+ HGV+ AK + V DATCP V K H +++G ++G + Sbjct: 64 -AAGSALLLRTHGVTPQEEQIAKDGCVDVLDATCPFVKKAHRAAELLAKQGYAVYVVGES 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT--VKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEVE T+ ++S ++V ++ +K+ + QTT+S S+V++A Sbjct: 123 GHPEVEATLAHVPGS----LAIDSVEEVAAQADAMRVAKKVGLVVQTTMSAAKLSEVVNA 178 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + ++ + IC AT Q++ LA++++V++++G + S+N+ RLAE+++ Sbjct: 179 VLPLVDEL--RVMNTICEATAGHQDSCMRLAKESDVMIIIGGRISANTTRLAEISKLYCP 236 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 + I+ ++Q W + + +G+TAGAS P+ + V ++++ G Sbjct: 237 ATYHIEGTDELQASWFEGAEHIGITAGASTPEAHINAVKLAIEEIVGA 284 >UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Desulfovibrionales RepID=ISPH_DESVH Length = 290 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 130/294 (44%), Gaps = 13/294 (4%) Query: 1 MQILLANPRGFCAGV-------DRAISIVENALAIYGAP--IYVRHEVVHNRYVVDSLRE 51 M ++ A GFC GV DR + E A I ++HN V+++ Sbjct: 1 MNVIRARTAGFCMGVSLALRKLDREVDRAEEKAAQGSPRCRIATFGPIIHNPQVLEAYAG 60 Query: 52 RGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 G + Q+ EV G ++ AHGV Q +SRD V DATCP V K + + R Sbjct: 61 MGVRCLRQVDEVEAGDHVVIRAHGVPQQQEKALRSRDAVVVDATCPKVKKAQLGIEEQCR 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G +L G A HPEV G + G + S D++ L ++ E + QTT Sbjct: 121 AGRTLLLFGEAEHPEVRGLLSYAG---EGALVFGSVDELEGLPLQPETEYFLAAQTTQDR 177 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 L +R P + IC AT RQ+ +A + + ++VVG +S N+ RL Sbjct: 178 VAFEVARAWLHERLGH-EVPVLETICDATRLRQQEAIDIARKVDAMVVVGGFDSGNTRRL 236 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 A++A G +++ + E ++ +G+TAGAS P ++ L+ L Sbjct: 237 ADVAAAQGVFTVHVENESQLPVEQLRGCGIIGLTAGASTPKSIIDATQRFLESL 290 >UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=bacterium Ellin514 RepID=B9XIS3_9BACT Length = 297 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 93/288 (32%), Positives = 143/288 (49%), Gaps = 9/288 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+ A G C GV AI++ P+ + ++VHN V+ +LR G F ++I Sbjct: 14 MNIIRAEHMGMCFGVRDAITLA--TKETASTPLTILGDLVHNETVLSNLRAHGIKFEQEI 71 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V + ++ +AHG S+ NE K+R L V +ATCPLV H VA +R G ++IG Sbjct: 72 EAVTTDS-VMITAHGASEKSINEIKARGLKVLEATCPLVHFAHRSVAELARDGYHPVIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G + +V S D+ L + + QTT ++ ++ Sbjct: 131 KRDHVEVRGLTGDLKAFD----VVLSEADIENLQERA--RFGIAAQTTQPIEKVQRLVGI 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +RK+FP D +C T RQ A LA++++VV+VVG +S+N++ L + R Sbjct: 185 VRKKFPNSEVRFVDTVCRPTKQRQFAAVELAQKSDVVVVVGGAHSNNTHELVKTCGRYCP 244 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 R + A D++ EW + VG+TAG S PD + V L+QL Sbjct: 245 RVHHVQFANDLRSEWFENAGIVGITAGTSTPDSTINEVEQALRQLADN 292 >UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipelotrichaceae RepID=A8RBC4_9FIRM Length = 303 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 107/294 (36%), Positives = 159/294 (54%), Gaps = 19/294 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAISI + Y IYV +VHNRYV+ +L+ ++ Sbjct: 1 MEIIKVVPRGYCKGVTRAISIAKETAQKYPDKSIYVLGMLVHNRYVMQALKALNIHAVDD 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + E+P I+IF+AHG++ V +AK L DA+CP V K V Sbjct: 61 PHKSRLQLLDELPKDCIVIFTAHGIAPQVIEKAKQMGLICIDASCPDVVKTQQLVYEKLN 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G + IG HPE E + S ++L+ S +D+ +T N + QTT+S+ Sbjct: 121 EGYDVFYIGKRSHPEAEAVLSLSS----HVHLITSKEDIDTIT--NVTNVFVTNQTTMSI 174 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQA-EVVLVVGSKNSSNSNR 230 DT + + +++++P V ++IC AT RQEAV L QA +V+ VVG K+S+NSNR Sbjct: 175 FDTQALFNYIKQKYPNAV--LCEEICNATRIRQEAVANLKNQAIDVLYVVGDKHSNNSNR 232 Query: 231 LAELAQRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 LA++AQ +LIDD DI+E + K +G+T+GAS P L V+ L+ Sbjct: 233 LAQIAQENKIANVYLIDDVNDIEEAQFAKAKRIGITSGASTPTYLTSQVIHYLE 286 >UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XKP1_CALS8 Length = 662 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 86/287 (29%), Positives = 143/287 (49%), Gaps = 6/287 (2%) Query: 1 MQILLANPRGFCAGVDRAIS-IVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV+RA++ ++ A A + V ++HN YV++ L+E IE Sbjct: 1 MIIKVAKNAGFCFGVERAVNGVIAWAKANKDKSVKVYGMLIHNSYVIEKLKELNVKVIEN 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I+E+ I+ +HGVS +E + R V+D TCP V K+H V S G + I++ Sbjct: 61 INEIEKDDIVFIRSHGVSMEEFSEIEKRASKVYDFTCPYVKKIHEIVRENSENGLDVIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G +G + +++S + + + QTT ++ + Sbjct: 121 GDINHPEVKGIIGHVE-KDRKCIVIDSLEKAKDAISQLGRNAVVVCQTTFDNAKWCEIKE 179 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + D +C AT RQE + LA +V+LV+G K SSN+N+L + + + Sbjct: 180 YIEN---NTEYKVFDTVCKATITRQEEAKVLALDVDVMLVIGDKKSSNTNKLYQAVKDI- 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 K F I+ +D++ +VK +G+TAGAS + +V L++ Sbjct: 236 KPTFFIERPQDLEGIDFTKVKKIGITAGASTSQEQISEIVEILEKRF 282 >UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0033 Length = 284 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 9/288 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I LA GFC GV+RA+++ + ++ + I+ ++HN +V + L+ +G +++ Sbjct: 2 IKLAKSAGFCFGVERAVNLAYSNASL--SNIFTFGPIIHNDFVTNDLKLKGVEIAYELT- 58 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 P +I +HGV + + +A + + DATCP V K+H V + G+ I+IG Sbjct: 59 -PRIKNVIIRSHGVGENIYKQADHLGINIIDATCPYVKKIHNLVKQHIILGQSIIIIGDK 117 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPE+ G G ++ +++ D + N + + QTT + + +I L Sbjct: 118 LHPEIIGINGWTND---NAIIIKDEFDSNIPLLDNTKSYFVVAQTTYKQEVVNRIIQLLE 174 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 + I IC TT RQ+ R+LA+ + +++VG +NSSN+ +L E+ K + Sbjct: 175 EN--HITFNYVHTICSTTTKRQQEARSLAKNVDTMIIVGGRNSSNTKKLFEICLSECKNS 232 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 I++A ++ + + +G+TAGAS P ++ +V++ + GE Sbjct: 233 LCIENASELAKIKFNKDSDIGITAGASTPKYIIDDVISYINNTIKGEI 280 >UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PSH0_9SPIO Length = 333 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 90/290 (31%), Positives = 134/290 (46%), Gaps = 10/290 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 + A G+C GV RA+ V ALA Y +Y ++HN + L +G + Sbjct: 48 VKRAQVLGYCMGVRRAVDAVYRALADYPDKTVYTYGPLIHNPVTMRLLEAKGVHIVNPDE 107 Query: 62 EVPDGAILIF----SAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+ I AHG+S R E + DATCP V + A+ S++G I Sbjct: 108 ELKPQIIPQSPIIIRAHGISPQKRQELIDCGAIIIDATCPKVIASQFKAAQYSQKGYTVI 167 Query: 118 LIGHAGHPEVEGTMGQY-SNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 L G H E+ G G S P G V++ + L + + QTT+ D+ Sbjct: 168 LAGDRNHGELIGIRGYVLSVPNGKCITVQTAAEAETLQ-DDGAPTVLIAQTTIKRDEYRA 226 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 + D L K+ + + IC AT RQEA+ L ++ + +LVVG NS+N+ RL + A Sbjct: 227 IADILHKKIAHLT--VLETICSATDERQEALLELVKEVDAILVVGGSNSANTRRLLQTAV 284 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 GK A+L + A DI E V +G+ AGAS PD + + + L +L Sbjct: 285 DSGKPAWLAETAADIPSE-VCCYHTIGLAAGASTPDSSIDTIESILDKLP 333 >UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dunaliella salina RepID=C5H8E3_DUNSA Length = 474 Score = 296 bits (759), Expect = 6e-79, Method: Composition-based stats. Identities = 90/354 (25%), Positives = 148/354 (41%), Gaps = 59/354 (16%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIE--- 58 + LA G+C GV+RA+ + A + G I+V +E++HN V LRE ++ Sbjct: 112 VKLAKAYGYCWGVERAVRMAYEARRAFPGRSIHVTNEIIHNPEVNRRLREMDVNIVKEDP 171 Query: 59 ----QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 S++ +G ++IF A GV + + + + D TCP V KV V +++ Sbjct: 172 QKGKDYSKIDNGDVVIFPAFGVGAPDMKYFRDKGVNIVDTTCPWVAKVWNSVDTYAKKKC 231 Query: 115 ESILIGHAGHPEVEGTMGQYS------NPEGGMYLVE---SPDDVWKLTVKNEE------ 159 SI+ G H E T + Y+ + D + K + Sbjct: 232 TSIIHGKYSHEETVATASFAEDYLIIKDLNEAQYVCDYILKGGDREEFMKKFSKAVSKGF 291 Query: 160 -------KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATTNRQ 204 ++ QTT+ +T + L + + GP D IC AT RQ Sbjct: 292 DPDVHLNRVGLANQTTMLKGETQAIGKMLERTMMEKFGPQNLQDHFMVMDTICDATQERQ 351 Query: 205 EAVRALAEQ--AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ---------- 252 +A+ + + +++LVVG NSSN++ L E+ G AF +D A I Sbjct: 352 DALYEITDDPTIDMMLVVGGFNSSNTSHLQEIPHNKGLPAFWVDTADRIDMASNSIAHKL 411 Query: 253 --------EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 E W+ E +GVT+GAS PD V+ V+ R+ ++ ++ RE Sbjct: 412 HYGELKVTENWLPEGPITIGVTSGASTPDRAVEEVLERVFRMKDPNFKGIQPRE 465 >UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema denticola RepID=ISPH_TREDE Length = 289 Score = 296 bits (758), Expect = 7e-79, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 138/295 (46%), Gaps = 18/295 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP---IYVRHEVVHNRYVVDSLRERGAIFI 57 M + A G+C+GV RA+ V +Y ++HN + L++ G I Sbjct: 1 MVVKRAEVLGYCSGVRRAVDTVLKLAKENTENKSGLYTFGPLIHNPSTMLRLKQMGVRTI 60 Query: 58 EQI----SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 + E ++++ AHG+ + ++E + V DATC V + S Sbjct: 61 DTENFTEDEDYKDSVIVIRAHGIPPSKKSELEKSGAKVIDATCSRVKASQALAKKHSEEA 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKN----EEKLSFMTQTTL 169 IL G H E+ G EG +V++ ++ + + + + QTT+ Sbjct: 121 F-VILAGDKNHGELISIAGYA---EGKCLIVQNAEEAALIDLPSSLSANGSAVLIAQTTI 176 Query: 170 SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSN 229 + + AL+KR + + IC AT++RQ A++ LA + + +LV+G KNS+N+ Sbjct: 177 KESEYEAIASALKKRISDL--KVFNTICPATSDRQAALKKLAYEVDALLVIGGKNSANTK 234 Query: 230 RLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 RL + A K A+LI+DA +I +E +G+TAGAS PD ++ V +L + Sbjct: 235 RLFQTAVDTKKPAWLIEDASEIPKEIFS-YSVIGLTAGASTPDFIIDEVEKKLLE 288 >UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B0MQU3_9FIRM Length = 658 Score = 295 bits (756), Expect = 1e-78, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 148/311 (47%), Gaps = 17/311 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I A GFC GV RA+ I E G+ Y E++HN + L++ G I+ Sbjct: 5 NIETAKSAGFCFGVKRAVEIAEKTAEENGSC-YTLGELIHNGSEIARLQKLGVYPIDSPD 63 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 ++P G LI +HGV+++V + + ++ DATCP V K+H V S+ I+ G Sbjct: 64 DLPQGRTLIIRSHGVAKSVTDYIHDKGISCIDATCPFVAKIHNIV---SKSECPVIIAGD 120 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT----VKNEEKLSFMTQTTLSVDDTSDV 177 HPEV G +G NP+ + +V D++ K+ + L + QTT + Sbjct: 121 PDHPEVIGIVGHCRNPD-EVSVVRDSDELEKMAELQKFPRQNALIMVAQTTFNSSKWQSC 179 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I +K + I D IC AT RQ+ LA ++ +++ VG KNSSN+ +LA+++Q+ Sbjct: 180 IQVAKKHYTNIT--IFDTICSATAERQKETEELARRSALMVTVGGKNSSNTAKLAQISQK 237 Query: 238 MGKRAFLIDDAKDIQEEWVKE-----VKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 D DI + V E VG+TAGAS P +++ V + ++ E Sbjct: 238 HC-PVIFTQDGSDIDKAAVSELLPLQGGTVGITAGASTPAYIIKEVHRIMSEILNNEEGF 296 Query: 293 LEGREENIVFE 303 E + F+ Sbjct: 297 DFMAEVDKTFK 307 >UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPH_KOSOT Length = 298 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 144/300 (48%), Gaps = 17/300 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV+RA+ + L V ++VHN V+ L++ G + Sbjct: 1 MKIVLAESLGFCYGVNRAVEATKRLLKEK-RDARVIGDIVHNEIVMKKLKDMGLKVYPDL 59 Query: 61 SEVP-----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + + ++ I AHG S V + K R V D TCP+V V ++G Sbjct: 60 SSIDFSDTAENSVAIIRAHGASPDVEDFLKRRFGYVVDLTCPIVYNVFSLAKDLEKKGYF 119 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK----LTVKNEEKLSFMTQTTLSV 171 ++ G H EV+ G+ ++ +VE D L K +K++ ++QTT++ Sbjct: 120 IVIFGKKDHAEVKALCGRLNDY----LIVEPGYDFETIKAFLREKKPKKVALISQTTMNS 175 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 + + + L + I + IC T NR++ LA+ + V+VVG K SSN+ +L Sbjct: 176 ESFEKLAEKLL-KLEGIEVSVNNTICNVTINREKMAIHLAQTCDAVVVVGGKRSSNTGKL 234 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 A++ + GKRAF + + + + + + + VG+ +G S P + ++ ++ GE I Sbjct: 235 AKIVESHGKRAFHVQNPEQLPD--LSIYRKVGIISGTSTPKEQILKILDYIKFTYEGEVI 292 >UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MT01_9CHLO Length = 523 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 90/338 (26%), Positives = 147/338 (43%), Gaps = 56/338 (16%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIE--- 58 + LA+ GFC GV+RA+ + A Y A +++ +E++HN V L + G FIE Sbjct: 174 LKLADAYGFCWGVERAVQMAYEARKQYPDAKLWITNEIIHNPTVNKRLGDMGVNFIEETK 233 Query: 59 ---QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S V +G ++I A G S + ++ D TCP V+KV V +R+ Sbjct: 234 DGKDFSGVGNGEVVILPAFGASVHEMKLLAEKGASIVDTTCPWVSKVWNAVDAHTRKEFT 293 Query: 116 SILIGHAGHPEVEGTMGQY------SNPEGGMYLVE---SPDDVWKLTVK---------- 156 SI+ G H E T + + YL + + D + K Sbjct: 294 SIIHGKWAHEETVATASFAGTYLVIKDMKEATYLCDYILNGGDKEEFMAKFVNAHSEGFD 353 Query: 157 ---NEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATTNRQE 205 + + L QTT+ +T + L + + G D IC AT RQ+ Sbjct: 354 PDVDLDGLGIANQTTMLKGETQAIGKLLERTMMEKHGVANLADHYMVMDTICDATQERQD 413 Query: 206 AVRALAE-QAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQE----------- 253 A+ L E + +++LVVG NSSN+ L E+++ +F +D + + E Sbjct: 414 AMYQLVEDKPDMMLVVGGYNSSNTQHLQEISEDASVPSFWVDTPERLDEDNVIAHRLAHG 473 Query: 254 ------EWVKEVK-CVGVTAGASAPDILVQNVVARLQQ 284 +W+ E +GVT+GAS PD +V++VV + + Sbjct: 474 ELVETKDWLPEGDVVIGVTSGASTPDKVVEDVVDMIFK 511 >UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AGH3_SEBTE Length = 291 Score = 293 bits (750), Expect = 7e-78, Method: Composition-based stats. Identities = 85/290 (29%), Positives = 154/290 (53%), Gaps = 12/290 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+ A GFC GV A+ V + + IYV +VHN +V++ L ++G IF+ + Sbjct: 6 EIIRAEHMGFCFGVREAVDEVHRYVDMNRGQIYVLGMLVHNEFVIEKLLKKGVIFVSEED 65 Query: 62 EVPD------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + + G I+I AHG +Q V+ + + + D C V +V +RG + Sbjct: 66 VLNNNTPLKSGDIVIIRAHGTTQNVQKKLLEIGVKLIDMACIYVKSARDQVVIWEQRGYK 125 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 S+ IG HPEV+G P + S D++ + + EK F+ QTT + Sbjct: 126 SVFIGDKDHPEVKGITSYGIKP----LIFGSLDELKQAELDINEKWVFLFQTTYNRFIFQ 181 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 ++ D + RF I IC AT RQ A+ LA++ + V ++GS+ SSN+ +L +++ Sbjct: 182 EINDYIINRF--INYKVVKTICGATHQRQSAIEKLAQEVDAVFIIGSEQSSNTKKLYQIS 239 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + + ++++LI++ DI++ + V+ +GV+AGAS P+ L+ + ++++L Sbjct: 240 KNLNEKSYLIENNDDIKKHMLDGVRKLGVSAGASTPEELIAIIENKIKEL 289 >UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Cyanobacteria RepID=ISPH_ACAM1 Length = 415 Score = 292 bits (749), Expect = 9e-78, Method: Composition-based stats. Identities = 84/359 (23%), Positives = 141/359 (39%), Gaps = 65/359 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFI---- 57 I LA GFC GV+RAI++ + I++ +E++HN V +LR+ FI Sbjct: 57 IHLAEAFGFCWGVERAIALAYETRRQFPQERIWITNEIIHNPSVNKNLRDMKVEFIPVQP 116 Query: 58 ---EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + + V ++I A G S + T+ D TCP V+KV V + + Sbjct: 117 DGQKDFTVVGQNDVVILPAFGASVQEMQLLHDKGCTIMDTTCPWVSKVWTSVEKHKKGSY 176 Query: 115 ESILIGHAGHPEVEGTMGQYS------NPEGGMYL---VESPDDVWKL------------ 153 SI+ G H E T N E Y+ + +P D Sbjct: 177 TSIIHGKYKHEETIATSSFAGTYLVLLNLEEAEYVADYILNPGDTPSEREQRRADFMAKF 236 Query: 154 ---------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDI 196 + E++ QTT+ +T + + + GP + I Sbjct: 237 ANAHSPGFDPETDLERVGIANQTTMLKGETEQIGKLFERTVMRKYGPAQVNEHFLSFNTI 296 Query: 197 CYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQE-- 253 C AT RQ+A+ L ++ ++++V+G NSSN+ L E++ ++ ID I Sbjct: 297 CDATQERQDAIFQLVDEPLDLMVVIGGFNSSNTTHLQEISIDKNIPSYHIDSVDRIGPGN 356 Query: 254 ---------------EWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 W+ +GVT+GAS PD +V ++V ++ + A + R Sbjct: 357 RVEHKPLNADLTVTDNWLPNGPLAIGVTSGASTPDKVVSDIVEKIFSIKSASAEVVGVR 415 >UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H149_9FIRM Length = 703 Score = 289 bits (740), Expect = 9e-77, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 146/305 (47%), Gaps = 9/305 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQ 59 +I+L GFC GV AI + A A I+ +++HN+ VV+ L ERG + ++ Sbjct: 12 KIILVEGSGFCFGVKNAIQKAKRARAELDKEIFTLGDIIHNKVVVEDLNERGITAVGEDE 71 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I + G+ ++ +HG S+A +A D + DATCP V ++H V S +G I++ Sbjct: 72 IETLKRGSNIVVRSHGASRAFFEKAAGLDFNLIDATCPYVLRIHTLVKNESLKGRVIIIV 131 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVI 178 G+ HPEV G G + + ++ ++ K + K + + QTT+ + V Sbjct: 132 GNEEHPEVAGISGWCCGEKAVISENSKKSEIEEICEKYKGKEMVVVGQTTIKQEAYERVC 191 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + ++ D +C TT RQE A+ + ++V+G SSNS +L E+ + Sbjct: 192 EVIKS--VNDHAEVMDTLCSITTTRQEKAFECAKNVDAMIVIGDSKSSNSLKLYEICSSV 249 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG----GGEAIPLE 294 K F I++ D+ + + +GV A ASAP +++ V+ + + G E + L Sbjct: 250 NKNTFFIENKSDLPLKKLSNCTTIGVVASASAPGQIIREVMVIMNENQNETTGNEMLELM 309 Query: 295 GREEN 299 E Sbjct: 310 DEIEK 314 >UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Chlamydomonas reinhardtii RepID=A8JEV9_CHLRE Length = 465 Score = 288 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 86/347 (24%), Positives = 145/347 (41%), Gaps = 67/347 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENA-LAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA G+C GV+RA+ + A LA ++V +E++HN V L+E +E Sbjct: 101 VKLAKAYGYCWGVERAVRMAYEARLAHPDKKVFVTNEIIHNPEVNSRLKEMNIEIVEDEG 160 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + G ++IF A G + + K + + + D TCP V KV V +R+ Sbjct: 161 KGKDYSMIGGGDVVIFPAFGATVQELTDFKEKGVQMVDTTCPWVAKVWNSVDTHTRKQYT 220 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------- 153 S++ G H E T SN +V+ + + Sbjct: 221 SVIHGKYSHEETIATASFASNY----IIVKDLKEAQYVCDYILQGGNREEFLQKFSKAVS 276 Query: 154 ----TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATT 201 +++ QTT+ +T + L K GP K + IC AT Sbjct: 277 AGFDPETMLDRVGLANQTTMLKGETEQIGKMLEKTMLTKYGPAKLNDHFLLMETICDATQ 336 Query: 202 NRQEAVRALA--EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEE----- 254 RQ+A+ + + ++++VVG NSSN++ L E+A+ G +F +D A I E Sbjct: 337 ERQDALYEMVADPEIDMMIVVGGFNSSNTSHLQEIAEHKGLASFWVDSAARIDVEKNVIL 396 Query: 255 -------------WVKEVK--CVGVTAGASAPDILVQNVVARLQQLG 286 W+ K +G+T+GAS PD V+ V+ ++ ++ Sbjct: 397 HKLAHGELKETTGWLNPGKPVTIGITSGASTPDRAVEEVLHKVFKIY 443 >UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=115 Tax=cellular organisms RepID=ISPH_SYNR3 Length = 406 Score = 286 bits (732), Expect = 7e-76, Method: Composition-based stats. Identities = 87/352 (24%), Positives = 142/352 (40%), Gaps = 64/352 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIF----- 56 I LA GFC GV+RA++I Y I++ +E++HN V L E +F Sbjct: 57 IRLAEAFGFCWGVERAVAIAYETRRHYPTERIWITNEIIHNPSVNAHLVEMNVLFIPVEE 116 Query: 57 -IEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 ++ S V G ++I A G + R + D TCP V+KV V R + Sbjct: 117 GVKDFSGVESGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWNSVERHKKNSFT 176 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------- 153 S++ G H E T G +V ++ + Sbjct: 177 SVIHGKVKHEETLATSSFA----GTYLVVLDLEEAQLVCDYILGNGNREAFLKRFAGATS 232 Query: 154 ----TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATT 201 ++ ++ QTT+ +T D+ + + GP + IC AT Sbjct: 233 PGFDPDRDLSRIGVANQTTMLKSETEDIGRLFERTLLRRYGPTDLNDHFLAFNTICDATQ 292 Query: 202 NRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI--------- 251 RQ+A+ +L ++ ++++V+G NSSN+ L E+A G + ID + I Sbjct: 293 ERQDAMFSLVDEPLDLMVVIGGYNSSNTTHLQEIAVSRGIPSVHIDAPERIGPGNAVEHK 352 Query: 252 ----QEEWV-----KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE 294 E + + +G+T+GAS PD +V+ V+ RL QL I E Sbjct: 353 PLGQDLERLEPFLPEGDLRIGITSGASTPDRVVEGVIDRLLQLAEAGQIAAE 404 >UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Bacteroidales RepID=ISPH_PARD8 Length = 290 Score = 283 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 81/295 (27%), Positives = 136/295 (46%), Gaps = 14/295 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQ 59 ++ + GFC GV AI E L +Y ++VHN V+ L G I E Sbjct: 3 EVEIDKDSGFCFGVVTAIESAERELGNTDT-LYCLGDIVHNSLEVERLEHMGLHTIDHEG 61 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE----E 115 +S + D ++ AHG + AK ++T+ DATCP+V ++ ++ + + + Sbjct: 62 LSRLRD-RKVLLRAHGEPPSTYALAKRNNITIIDATCPVVLRLQRKIHKCYQETRANNTQ 120 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 ++ G GH EV G +GQ EG ++E +D+ +L +S +QTT S+D Sbjct: 121 LVIYGKKGHAEVNGLVGQ---TEGTAIVIEKIEDLDRLDF--TRAISLFSQTTKSLDGFK 175 Query: 176 DVIDALRKRFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 V+ +++R + + D IC NR ++A A + V V + SSN L E Sbjct: 176 AVVAEIKQRMAEGVEFNYYDTICRQVANRLPNIKAFASSHDWVYFVAGRKSSNGKMLFEE 235 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 ++ I + +I E + V+ VGV S P L++ V R+++L E Sbjct: 236 CRKANPNTLFISEVSEITEPLPEGVRRVGVCGATSTPKWLMEEVAVRIKELNASE 290 >UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Prevotella RepID=D1Y0F8_9BACT Length = 304 Score = 283 bits (725), Expect = 5e-75, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 132/305 (43%), Gaps = 30/305 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 +QI + + GFC GV AI E LA G +Y ++VHN V+ L G + I E Sbjct: 2 LQIEIDSGSGFCFGVTTAIKKAEEELAK-GTKLYCLGDIVHNSMEVERLETNGLVTIDHE 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR------ 112 Q+ ++ + +L AHG AK ++ + DATCP+V + + + Sbjct: 61 QMKKLHNVKVL-LRAHGEPPETYELAKRNNIEIIDATCPVVLALQRRIKKQYESKLDDKL 119 Query: 113 --------------GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNE 158 G + ++ G GH EV G +GQ + ++E +DV KL + Sbjct: 120 EDKQMEFVPESTSVGSQIVIFGKNGHAEVLGLVGQ---TKSEALIIEKFEDVKKLNFTKD 176 Query: 159 EKLSFMTQTTLSVDDTSDVIDALRKRF-PKIVGPRKDDICYATTNRQEAVRALAEQAEVV 217 + +QTT S+++ +I+ ++ P D IC NR + A + +V+ Sbjct: 177 --IYLYSQTTKSLNEFHQIIEYIQSHIDPSAKFQSFDTICRQVANRMPNISTFATRHDVI 234 Query: 218 LVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQN 277 + V K SSN L + R++ ++ A +I W + V VG+ S P L++ Sbjct: 235 IFVAGKKSSNGKVLFHECLDVNPRSYQVECADEIDMSWFEGVNTVGICGATSTPKWLMEE 294 Query: 278 VVARL 282 + Sbjct: 295 CRDEI 299 >UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Bacteria RepID=C3RLQ9_9MOLU Length = 303 Score = 283 bits (724), Expect = 7e-75, Method: Composition-based stats. Identities = 91/301 (30%), Positives = 152/301 (50%), Gaps = 19/301 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M++ PRG+C GV RAI + + +Y+ +VHN+Y+VD+L G I++ Sbjct: 1 MKVYPITPRGYCKGVVRAIELAKKQAHQDD--VYILGMIVHNQYIVDALNNLGVKTIDKK 58 Query: 60 -------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + +V G +I +AHG S V +A S+++ V +ATCP V K H + + Sbjct: 59 GASREELLDQVSQG-TVIITAHGASHNVIKKAHSKNIQVINATCPDVIKTHDLIKNYLNQ 117 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G E + IG AGHPE EG + ++L+E+ D L QTT+S+ Sbjct: 118 GIEILYIGKAGHPESEGALSI---DPAHIHLIENKTDFENL--DPNLNYVITNQTTMSLY 172 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D D+ + + + ++ K+ C ATT RQEA+ + ++ +V+ +VG +S+N+ +LA Sbjct: 173 DVYDLCEYAKTKLNNLIV-AKET-CQATTVRQEAIAKINDEVDVIFIVGDPHSNNTKKLA 230 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +A ++ K ++I+ DI +KE V++GAS P L V+ L+Q Sbjct: 231 SIAHEKANKDTYMIESVNDIDISMLKEKHAAAVSSGASTPTYLTNQVIEYLRQFDYQNVS 290 Query: 292 P 292 Sbjct: 291 T 291 >UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellularis PHE/MN1-00 RepID=Q1MQE5_LAWIP Length = 294 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 129/289 (44%), Gaps = 9/289 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGA---PIYVRHEVVHNRYVVDSLRERGAIFI 57 MQ++ A G C GVD A+ + ++ + ++HN V+ + +G I + Sbjct: 9 MQVIRAKTAGTCWGVDLALRKLSQSIENKEKANTRFVMYGLIIHNPQVIVEYKAQGVICV 68 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + I EV G +I AHG+ + + + DATCP V K + +A A+ + Sbjct: 69 DSIEEVRAGDTVIIRAHGIPIYEEQQLTDIGINLIDATCPKVKKTQLAIANATNSETILL 128 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 L G A HPEV+G + P ++ ++ V + + +QTT ++ Sbjct: 129 LFGEANHPEVKGLISYSQGP---FHVFDTKQFVEDFDNSQNKTIVLASQTTQDEITFKEI 185 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + L ++ I + IC AT RQ + ++ EQ ++VVG S N+ RL EL++ Sbjct: 186 QEILHQK--GIQPVILNTICDATYKRQRELLSITEQVNTMVVVGGFTSGNTRRLVELSKA 243 Query: 238 MGKRAFLIDDAKDIQE-EWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 G + F I+ + + + +G+T GAS P L+ V L Sbjct: 244 KGIKTFHIETVDALYGNNELDQNDIIGLTGGASTPKQLIDKVEDFLSNN 292 >UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mycoplasma penetrans RepID=ISPH_MYCPE Length = 299 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 89/301 (29%), Positives = 154/301 (51%), Gaps = 20/301 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRGFC GV A + + +Y Y+ +VHN+ ++ L E G + Sbjct: 1 MKIIKITPRGFCKGVVDAYATCKKIAKLYPNHEKYLIGWLVHNKEIIKELEELGIQTKDD 60 Query: 60 -------------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 I + + I+IFSAHG Q ++A+ + L VFD TC VTK H + Sbjct: 61 KNHSRSEIIDSIEIKDKNNPPIVIFSAHGTDQKTIDKAREKGLVVFDTTCIYVTKTHDLI 120 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQ 166 +G + IG HPE T+ + + L+E+ +D+ + ++E+ + Q Sbjct: 121 KEKIEQGYQIFYIGVNNHPETISTLS----IDKSIILIETVNDIENIRTESEKPIFVTNQ 176 Query: 167 TTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSS 226 TT+S+ + ++ + L+ ++ I K+DIC A +RQ+AV + + +++LVVG S+ Sbjct: 177 TTISIYEFEEITETLKSKYKNIEF--KNDICNAAKDRQDAVINMPSEVDLLLVVGDIKSN 234 Query: 227 NSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 NS +L E+ + + LI + K+I++EW KC+ +T+G S P L V+ L++ Sbjct: 235 NSKKLVEIGIKKQIESHLIWNTKNIKDEWFINKKCLAITSGCSTPTWLANYVIIFLEKKL 294 Query: 287 G 287 G Sbjct: 295 G 295 >UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=30 Tax=Bacteroidetes RepID=ISPH_CYTH3 Length = 293 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 145/298 (48%), Gaps = 21/298 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 M +++ G+C GV+ AI + E+ +A G P++ ++VHN V+ L ++G I E Sbjct: 1 MDVIIDKNSGYCFGVEFAIQMAEDEMAT-GEPLFCLGDIVHNSMEVERLAKKGLKIIDRE 59 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA-----SRRG 113 ++ ++ D +LI AHG A ++ + DA+CP+V K+ V + S+ G Sbjct: 60 ELKKLSDCKVLI-RAHGEPPETYQLALENNIELVDASCPVVLKLQNRVKASFDAIDSKDG 118 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 + ++ G GH EV G GQ + ++ + D+ K+ E+ ++ +QTT S Sbjct: 119 -QIVIYGQEGHAEVIGIAGQTGD---KAIVITTEKDLDKIDF--EKPVTLYSQTTKSTQG 172 Query: 174 TSDVIDALRKRFPKI------VGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSN 227 + D + R + D IC +NR+ +R +++ +VV+ V K SSN Sbjct: 173 FYKMKDLIEARVAEAGKNVDENFEYNDSICRQVSNREPQLRKFSKEFDVVIFVSGKKSSN 232 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 L + ++ +R++ +++ +I+ W++ VG+ S P L++ V +Q Sbjct: 233 GKALYGVCKQENERSYFVENETEIEPSWIRATDNVGICGATSTPMWLMEKVQNYIQAH 290 >UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=ISPH_THENN Length = 279 Score = 280 bits (718), Expect = 3e-74, Method: Composition-based stats. Identities = 93/288 (32%), Positives = 146/288 (50%), Gaps = 20/288 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VEN L G + E+VHNR V++ L ++G Sbjct: 1 MKIIVAKNVGFCFGVERAIRTVENLLNE-GKRVVTDGEIVHNRQVMEDLLKKGLKISSDP 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + DG + + AHG+ + + + V D TCP+V ++ S RG + I+ G Sbjct: 60 T---DGDVFVVRAHGIPEEKLEKLRKIYPEVVDLTCPIVFQLFRTAREYSSRG-KLIVFG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVID 179 HPE+ MG P V K K EEK + F++QTT S+D+ + + Sbjct: 116 KRDHPEMVALMGYA------------PAIVTKKPFKTEEKNVVFLSQTTSSLDEYREFVS 163 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K + IC T R+ V+ L++ ++ +VVG K+SSN+ +L LA R Sbjct: 164 EMIKMNNFEKAIYLNTICPVTVEREREVKELSKICDLSVVVGGKHSSNTGKLFRLASR-N 222 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 RA ++ +I E+ VK V V +G S P L++NVV +L+++ G Sbjct: 223 SRAIWVESPDEIPEDVVK-YGTVCVFSGTSTPVSLIENVVRKLEEMEG 269 >UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bacteroidales RepID=ISPH_AZOPC Length = 287 Score = 280 bits (718), Expect = 3e-74, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 136/294 (46%), Gaps = 15/294 (5%) Query: 1 MQ-ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI-- 57 M+ I + GFC GV AI E L +Y ++VHN V L+++G I Sbjct: 1 MKTIEIDCDSGFCFGVMSAIQRAEKELITNDE-LYCLGDIVHNSQEVVRLQKKGLKIINH 59 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVAR----ASRRG 113 E++ + + +L F AHG + A + + DATCP+V ++ ++ + + Sbjct: 60 EELGRIYNKKVL-FRAHGEPPSTYEVANQNSIHIIDATCPVVLQLQKKIQKIYQSFANTK 118 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 + +L G + H EV +GQ G ++ES +D+ ++ + + +QTT+ VDD Sbjct: 119 SQIVLFGRSKHAEVSALVGQ---TNGNAIVIESKNDIQQIDF--AKNIYLFSQTTMFVDD 173 Query: 174 TSDVIDALRKRFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 +++ + + I+ + IC+ NR +R A Q ++L V NSSN L Sbjct: 174 FKEIVKEIENKIIHPIIFSSFNTICHQMVNRINHIRKFAVQHNLLLFVAGDNSSNGTILF 233 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 +R +LI D KDIQ EW +K VG+ S P L++ + L Sbjct: 234 NECRRANLNTYLISDEKDIQSEWFNGIKSVGICGATSTPKWLMEKIALSLIPFH 287 >UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Prevotella RepID=C5VII4_9BACT Length = 335 Score = 280 bits (718), Expect = 4e-74, Method: Composition-based stats. Identities = 80/336 (23%), Positives = 132/336 (39%), Gaps = 61/336 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 +QI + N GFC GV AI E LA G +Y ++VHN V+ L ++G I I E Sbjct: 2 LQIEIDNGSGFCFGVTTAIKKAEEELAK-GTKLYCLGDIVHNSMEVERLTKKGLITINHE 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE--- 115 Q+ E+ + +L AHG A+ ++ + DATCP+V + + +G + Sbjct: 61 QMRELHNVKVL-LRAHGEPPETYELARRNNIEIIDATCPVVLALQRRIKTQYEKGRQPSY 119 Query: 116 ------------------------------------------------SILIGHAGHPEV 127 ++ G GH EV Sbjct: 120 MISSKGGAAVDEPSSLKPVTNEAVETSISSVSLPPAVGEGQELSASSSIVIFGKNGHAEV 179 Query: 128 EGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRF-P 186 G +GQ ++E +DV L N+ + +QTT S+D+ +I+ ++ P Sbjct: 180 LGLVGQ---THSQAIVIEKFEDVKALDFNND--IYLYSQTTKSLDEFHKIIEYIQSHISP 234 Query: 187 KIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLID 246 K D IC NR + A + +++L V + SSN L + + ++ Sbjct: 235 KAKFQSFDTICRQVANRMPNISTFAARHDLILFVAGRKSSNGKVLFHECLSVNPNSHQVE 294 Query: 247 DAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 A +I W V+ VG+ S P L++ + Sbjct: 295 SADEIDMSWFDGVETVGICGATSTPKWLMEECRDEI 330 >UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Thermotogaceae RepID=ISPH_THESQ Length = 275 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 88/288 (30%), Positives = 148/288 (51%), Gaps = 20/288 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VE L G + E+VHN+ V++ L ++G Sbjct: 1 MKIVVAKNIGFCFGVERAIRTVEELLDE-GKKVVTDGEIVHNKQVMEQLTKKGLKVS--- 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SE+ DG + + AHG+ + E K V D TCP+V+++ R ++ + I+ G Sbjct: 57 SEMTDGEVFVVRAHGIPKDRLEELKKIFPEVVDLTCPIVSQLFKTAQRYAKE-RKVIVFG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVID 179 HPE+ G P V K+ K EEK + F++QTT S+++ + + Sbjct: 116 KEDHPEMVALRGYA------------PAIVTKVPFKFEEKKVVFLSQTTSSLEEYKEFVA 163 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 A+ + + IC T NR+ V L++ ++ +VVG K+SSN+ +L +A + Sbjct: 164 AMIRMNEFEEAVFLNTICPVTVNREREVEELSKICDLSIVVGGKHSSNTGKLFRIASKHS 223 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K I+ ++ + VK V V +G S P+ L++NVV +L+++ G Sbjct: 224 K-TIWIESPDELPADVVK-YGTVCVFSGTSTPNSLIENVVRKLKEMEG 269 >UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196B3D1 Length = 324 Score = 278 bits (712), Expect = 2e-73, Method: Composition-based stats. Identities = 98/302 (32%), Positives = 164/302 (54%), Gaps = 19/302 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M++ PRG+C GV RAI+IV+ + G PI V +VHN+++VD+L++RGAI IE Sbjct: 22 MKVTGIVPRGYCKGVIRAINIVKETIEQPG-PITVLGMIVHNQFIVDALKKRGAITIEDA 80 Query: 60 -------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + E+ +G +I +AHG V +AKS+ L V DATC V K H + +R Sbjct: 81 SKTRMELLDEINEG-TVIITAHGAGDCVIEKAKSKGLNVVDATCLDVIKTHTLIKEQLKR 139 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G++ + IG HPE EG + +PE ++L+ S D+ L ++ QTT+S+ Sbjct: 140 GKDVLYIGKKNHPEAEGAL--LIDPE-HIHLITSKKDLETL--DKDKHYVMTNQTTMSLY 194 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D D+ + ++ + + C AT RQEA+ + E ++V++VG +S+N+ +LA Sbjct: 195 DVYDLCEYAKEI---LDVEIMKETCSATQIRQEAIAKMDEDIDLVIIVGDPHSNNTKKLA 251 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 ++ ++ K +I +++ W+K K VGV++GAS P +L ++ L+Q Sbjct: 252 SISMEKAHKDTKMIGSLEELDLSWLKGKKHVGVSSGASTPTVLTNQIIDFLKQYDENNPD 311 Query: 292 PL 293 Sbjct: 312 SF 313 >UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8C2Y3_THAPS Length = 462 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 94/357 (26%), Positives = 159/357 (44%), Gaps = 65/357 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A+ + G +++ +E++HN V D L + FIE+ Sbjct: 105 VKVYLAKDFGFCWGVERSIALAYEAVEHFPGKTVHITNELIHNPEVNDKLHDMNVQFIEK 164 Query: 60 ISE-------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + E + +G ++I A G S ++++ V D TCP V+KV V + R+ Sbjct: 165 LGEGKKDFSKIGEGDVVILPAFGASFEEMTLMNNKNVEVVDTTCPWVSKVWNTVDQHQRK 224 Query: 113 GEESILIGHAGHPEVEGTMGQYSN----------PEGGMYLVESPDDVWKLTVKNE---- 158 G S++ G GH E T+ + Y++ D L + Sbjct: 225 GLTSVIHGKYGHEETVATVSFCEDYICVKDIKEAEMVADYIINGGDKEKFLKYFEKAVSK 284 Query: 159 --------EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDICYATTN 202 +K+ QTT+ +T + ++K K GP D IC AT Sbjct: 285 GFDPDTMLDKVGLANQTTMYKKETRAIGQLMQKAMMKKFGPVNAKDHYLEFDTICDATQE 344 Query: 203 RQEAVRALAEQA-----EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK-------- 249 RQ+A+ L E + + +LVVG +SSN+ L E+ ++ G R+F I+ ++ Sbjct: 345 RQDAISDLVENSDELGLDFILVVGGWDSSNTAHLLEIPEKAGVRSFHINKSECIGADNTI 404 Query: 250 -------DIQEEWV------KEVKCV-GVTAGASAPDILVQNVVARLQQLGGGEAIP 292 +I E K+ K V GVT+GAS PD VQ+ + ++ L + Sbjct: 405 THRTVDGEIVTEKFIEDIENKDKKLVMGVTSGASTPDKAVQDSLDQIFMLKKVYSKE 461 >UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium URE4 RepID=C0JZX4_9BACT Length = 288 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 84/293 (28%), Positives = 138/293 (47%), Gaps = 14/293 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +++ + + GFC GV RAIS E L +Y +VHN +D L G + I Sbjct: 2 VKVEIDSRSGFCGGVIRAISQAERFLQESD-HLYSLGAIVHNEAELDRLGAEGLRTVASI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVA----RASRRGE-- 114 +VP+G ++ AHG + +A+ R L V D TCP+V K+ + R G Sbjct: 61 PDVPEGETVLIRAHGEPPSTYADARRRGLVVIDCTCPVVLKLQEHIREAYARLHADGLHG 120 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVD 172 ++ G GH EV G +GQ +G +VE+ + + + + +QTT S Sbjct: 121 TLLIFGKIGHAEVLGLLGQV---DGDAIVVENRAMLEDALPAIDFSQPVEIFSQTTKSPA 177 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 + +++ D +R ++ D IC NR E + A A +++L V ++SSN L Sbjct: 178 EYAEICDRVRSLGDRVT--VHDTICAQVANRHEHLAAFARAHDLILFVAGESSSNGRVLF 235 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +L R+ R++ I DI WV++ VGV S P L++ V +++L Sbjct: 236 DLCHRLNPRSYRIGAPADIDPAWVRDGDHVGVCGATSTPQWLLEMVAEAVREL 288 >UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 Tax=Phaeodactylum tricornutum RepID=B7FUL0_PHATR Length = 458 Score = 277 bits (710), Expect = 3e-73, Method: Composition-based stats. Identities = 90/352 (25%), Positives = 155/352 (44%), Gaps = 72/352 (20%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A + +++ +E++HN V ++L+ + FIE+ Sbjct: 103 VKVYLAKDFGFCWGVERSIALAYEAAEHFPDRKLHITNELIHNPEVNENLKAKNVQFIEK 162 Query: 60 ISE-------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + + V DG ++I A G S + +++ + D TCP V+KV V + ++ Sbjct: 163 LGDGTKNFASVQDGDVVILPAFGASFEEMDYFDKKNVEIVDTTCPWVSKVWNTVDKHQKQ 222 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL------------------- 153 G S++ G H E T + V++ + + Sbjct: 223 GLTSVIHGKYAHEETVATTSFCED----FICVKNFKEAEMVANYILNGGDKDAFMKHFEN 278 Query: 154 -------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDICY 198 K+ EK+ QTT+ +T + +K K GP D IC Sbjct: 279 AVSEGFDPDKHLEKVGLANQTTMYKKETRAIGQLFQKTMMKKFGPVKSKEHYMEFDTICD 338 Query: 199 ATTNRQEAVRALAEQA-----EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK---- 249 AT RQ+A+ + E A + +LV+G +SSN+ L E+ G RAF I+ A+ Sbjct: 339 ATQERQDAIHDMVESAQKDGLDFILVIGGWDSSNTAHLLEIPVHAGIRAFHINRAECIGA 398 Query: 250 ----------------DIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + E+ KEV +GVT+GAS PD VQ+ ++++ L Sbjct: 399 DNTITHRTVDGEIVTTQLLEDMDKEV-VMGVTSGASTPDAAVQDSLSQIFLL 449 >UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Treponema RepID=ISPH_TREPS Length = 376 Score = 276 bits (708), Expect = 5e-73, Method: Composition-based stats. Identities = 83/322 (25%), Positives = 135/322 (41%), Gaps = 41/322 (12%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS- 61 I A+ G+C GV A+ + E+A A + +Y +VHN + LR RG ++ Sbjct: 10 ITRAHTLGYCGGVRMAVRMAEHARAHHRGSVYTLGPLVHNPVTLARLRARGIECLDPAHL 69 Query: 62 -----------------EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHM 104 E ++ AHGV+ V + V DATCP V + Sbjct: 70 SFALHAPAAPGAAPHAVEEKTARTVVIRAHGVAPEVYEALERSGAQVVDATCPRVKESQR 129 Query: 105 EVARASRRGEESILIGHAGHPEVEGTMGQYSN------------------PEGGMYLVES 146 + +G IL G H E+ G G P+ ++V++ Sbjct: 130 RAQGFAAQGLHVILAGDRNHGEIVGIEGYVRAGAAQACSHLPGGAPDGMLPQVQCFVVQN 189 Query: 147 PDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEA 206 + L + + + QTT++ + + A R R ++ R IC AT RQ A Sbjct: 190 AREAAAL--PCLARAALLAQTTITQGEYDAIAAAARTRVRELTVAR--TICAATARRQAA 245 Query: 207 VRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTA 266 +RALA E +LV+G +S+N+ RL A+ +L++ +DI + + VG++A Sbjct: 246 LRALAPTVEALLVIGGAHSANTQRLLHTARETSLPTWLVERVEDIPPD-IYAFSAVGISA 304 Query: 267 GASAPDILVQNVVARLQQLGGG 288 GAS PD ++ V L+ G Sbjct: 305 GASTPDCVIAAVEQALRTGGAP 326 >UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Bulleidia extructa W1219 RepID=D2MQD5_9FIRM Length = 300 Score = 275 bits (703), Expect = 2e-72, Method: Composition-based stats. Identities = 104/293 (35%), Positives = 156/293 (53%), Gaps = 22/293 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAI + + Y + + +VHN++VVD L + G IE Sbjct: 1 MEIISVQPRGYCHGVVRAIRLAQKTRETYPHTTMTILGMLVHNQHVVDELAKNGIHTIED 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + ++ +G I++F+AHGVS AV +AK + L + DATCP V K H + Sbjct: 61 HHQDRLSLLDKIQEG-IVVFTAHGVSPAVYEKAKEKGLQIVDATCPDVLKTHELIRNHPG 119 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 I +G HPE EGT+G S ++LV +D+ L + QTTLS+ Sbjct: 120 D---VIYLGKKNHPEAEGTIGLSS----RVHLVSCVEDLNTLQSFPLQDPIITNQTTLSL 172 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 D D+I A K++P R +IC AT RQEA+ L + +V+ VVG S+NSN+L Sbjct: 173 LDLQDLITACLKQYPNAKVVR--EICPATRLRQEAILNL--ETDVLYVVGDVRSNNSNQL 228 Query: 232 AELAQRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 +A++ G +I D+QE + E K + VT+G+S P+ L V++ LQ Sbjct: 229 VNIARKKGISFVKMISSVHDLQEHEIIEKKRIAVTSGSSTPNTLTNQVISFLQ 281 >UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Verrucomicrobia RepID=B4CZC4_9BACT Length = 287 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 85/286 (29%), Positives = 139/286 (48%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA G C GV AI+ E P+ + E+VHN V + L G Sbjct: 1 MKIQLAEHYGLCFGVRDAIAQAEELATR--GPLTILGELVHNPVVRERLARHGVREGALD 58 Query: 61 SEVPDGAI-LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + ++ +AHG S R E ++ V D TCPLV + H ++ +G ++I Sbjct: 59 DRDSAQSTQVMITAHGASDKARGEWRNAGFGVADGTCPLVLQAHEKLRALVEQGFVPVVI 118 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G GH EV G G + + ++ES +D+ L +L ++QTT + ++D Sbjct: 119 GKRGHVEVNGLTGDFPD----ACIIESAEDLANL--PTAARLGVISQTTQPSEKVLALVD 172 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 A+R P D +C T NRQ A+R L E+ + ++VVG +NS+N+ +L A G Sbjct: 173 AIRIARPASEVRFCDTVCQPTKNRQSALRKLIEECDTLVVVGGRNSNNTLQLVAAATVAG 232 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++ A++++ +W + + VG+TAG S V V RL+ + Sbjct: 233 RAVHHVERAEELRPDWFRAARVVGITAGTSTLKETVATVRIRLEAI 278 >UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPH_PETMO Length = 284 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 149/287 (51%), Gaps = 12/287 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC+GV + + V+N+L IY+ E+VHNR V++ L GAI I + Sbjct: 1 MEINVAKRTGFCSGVQKTYNEVKNSLVDKNK-IYIYGELVHNRKVIEELNSAGAITITGM 59 Query: 61 SEVPDGA---ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 ++PD + LI AHG+S+A ++ K R V D TCP+VT + V + + G + Sbjct: 60 DDIPDDSIDETLIIRAHGISKAEKDLLKKRFSKVIDMTCPIVTNLVKYVEKKQKDGFFVV 119 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G HPE+ G G + + L ++K+ ++QTT+ ++ + Sbjct: 120 VYGKPDHPEILGLKGNVDESKLLITL--------SPVTIPQKKVLIVSQTTMGEEEYKNF 171 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I ++ +D IC T R++ L++++ ++LV+G KNSSN+ +L ++++ Sbjct: 172 ITSILTINSFTEVLIRDTICSETILREKETLELSQKSTLMLVLGGKNSSNTQKLYRISKK 231 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 KR + I+ ++++E + +G+ G+S P + V+ L Q Sbjct: 232 YCKRTYHIESGEELKEITISPQDKIGIVTGSSTPTSELNKVLEYLSQ 278 >UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Chlorobiaceae RepID=ISPH_CHLP8 Length = 332 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 131/329 (39%), Gaps = 41/329 (12%) Query: 1 MQILLANPR-GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE- 58 M+I L GFC GV I + E L G +Y +VVHN V L G I+ Sbjct: 1 MKINLDRTSSGFCIGVQGTIHVAEEKLNQSGE-LYCLGDVVHNEVEVKRLEALGMETIDI 59 Query: 59 -QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+ D +LI AHG + A+ +L + D TCP+V K+ + G + I Sbjct: 60 PAFEELRDAEVLI-RAHGEPPSTYETARRNNLAITDTTCPVVAKLQKTAKMLHQLGYQVI 118 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G HPEV G GQ ++ + + D+ + K + ++QTT+ V ++ Sbjct: 119 IYGKKIHPEVIGINGQCNDEGVVIKHPDLSDEAEIAPLDLGRKTALISQTTMDVPGFYEL 178 Query: 178 IDALRKRFPKI-------------------------------VGPRKDDICYATTNRQEA 206 L K F + KD IC ++R Sbjct: 179 KKNLEKLFAEHGHRNPGTKSGEWMAVRDIDITSEKTGGRAMPELVYKDTICRQVSSRNGK 238 Query: 207 VRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWV-----KEVKC 261 +R A + ++ + SSN L + + ++ I+D +IQ EW K V+ Sbjct: 239 LRDFALANDCIVFAAGRKSSNGQVLYSICKDANPHSYFIEDVDEIQPEWFVGENGKPVES 298 Query: 262 VGVTAGASAPDILVQNVVARLQQLGGGEA 290 VG+ S P L++ V + + G ++ Sbjct: 299 VGICGATSTPMWLLEKVANYIGKTFGDDS 327 >UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q0DNV6_ORYSJ Length = 482 Score = 273 bits (698), Expect = 8e-72, Method: Composition-based stats. Identities = 77/353 (21%), Positives = 151/353 (42%), Gaps = 72/353 (20%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIF--- 56 ++++LA GFC GVD A+ + +A + +++ ++++HN V + L E G Sbjct: 123 VRLILAEAHGFCLGVDNAVRLAYDARVKFPDRRLWLTNQIIHNPTVSERLDEMGIKIIPV 182 Query: 57 ---IEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 ++ +S V DG ++IF A G + +++ + D TCPLV KV R + Sbjct: 183 VSGVKDLSVVEDGDVVIFPAFGFTVDEMVTLNRKNVHIVDTTCPLVLKVVHMTERHIKGN 242 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL-------------------- 153 +I+ G H E T +V+ + + Sbjct: 243 YTTIIHGKYAHEETVATASFADKY----IIVKDITEAKYVCDYILEGQLDGSSSTKEKFL 298 Query: 154 ------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKD------- 194 + E++ + QTT+ +T ++ + + G ++ Sbjct: 299 KKFRYAVSPGFDPDIDLERVGVVNQTTMLKGETKEIGILIEQTMMSKYGLDQNNKQEHFV 358 Query: 195 ---DICYATTNRQEAVRALA-EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD 250 IC AT RQ+A+ L ++ +++LVVG NSSN++ L E+ + G ++ +D + Sbjct: 359 RVGTICNATQERQDAMYKLVEKEVDLILVVGGWNSSNTSHLQEIGELSGIPSYWVDGEQR 418 Query: 251 I-----------------QEEWVK-EVKCVGVTAGASAPDILVQNVVARLQQL 285 I +++W+ +GVT+GAS PD +V++V+ ++ ++ Sbjct: 419 IGPGNKISYKQKNGELVEKDKWLPHGAITIGVTSGASTPDKVVEDVLQKVFEI 471 >UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Perkinsus RepID=B1Q2Q7_9ALVE Length = 575 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 95/386 (24%), Positives = 151/386 (39%), Gaps = 107/386 (27%) Query: 4 LLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI----- 57 LA GFC GV+RA++I + Y I++ +EV+HN V +L E G +I Sbjct: 177 KLAEAHGFCWGVERAVAIAYESSRRYPDKTIWMTNEVIHNPTVNRNLEELGIRYIPRDAG 236 Query: 58 --EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + S V G ++I A G + E K + +T+ D TCP V+KV V R + Sbjct: 237 NQKDFSVVSAGDVVILPAFGAAVKEMMELKRKGVTIVDTTCPWVSKVWSSVERHKKGEYT 296 Query: 116 SILIGHAGHPEVEGTMGQY------SNPEGGMYLVES---------PDDVWKL------- 153 SI+ G + H E T N + Y+ + DD ++ Sbjct: 297 SIIHGKSKHEETIATSSFADKYLILKNLKDAEYVCKFLLSKNKERLVDDFFEKFPADRHS 356 Query: 154 ----TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATT 201 +K+ EK+ QTT+ +T+ + K ++ GP + IC AT Sbjct: 357 VGFDPLKDLEKVGVANQTTMLKGETALIAKLFEKTILQLYGPEGLNEHFVAFNTICDATQ 416 Query: 202 NRQEAVRAL-------------------------------AEQAEVVLVVGSKNSSNSNR 230 +RQ+A+ L A + +++LVVG NSSN+ Sbjct: 417 DRQDALYKLVGEKYEQPQSDMLEELGVDTPKTTDPQVTPTATKLDMMLVVGGFNSSNTEH 476 Query: 231 LAELAQRMG----KRAFLIDDAKDIQE---------------------------EWVKEV 259 L E++ G RAF ID I E +++ Sbjct: 477 LQEISVEAGGVKDHRAFHIDGPARIDELRNTITHKPVETPPIEAARNHGLAVTHDFLPGD 536 Query: 260 K---CVGVTAGASAPDILVQNVVARL 282 +GVT+GAS PD +++ + +L Sbjct: 537 GEHITIGVTSGASTPDDVLEQSLQKL 562 >UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH n=5 Tax=Verrucomicrobia RepID=B3DZ81_METI4 Length = 419 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 88/355 (24%), Positives = 144/355 (40%), Gaps = 65/355 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA GFC GV+RAI + ++ I++ E++HN V D L G ++ Sbjct: 53 VKLAKAFGFCYGVERAIDLAYATTKVFPTKRIFLLGEIIHNPEVNDQLTAMGIKRLQAVE 112 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + + ++I A G + + D TC V V V + + G Sbjct: 113 GGYFLDGLTADDVVIIPAFGAEVETMKRIQQIGCQIVDTTCGDVMTVWKRVRQYRKEGAT 172 Query: 116 SILIGHAGHPEVEGTMGQYSNPEG-----GMYLVESPDDVWKLTVKNEEK---------- 160 SI+ G A H E + T + +G +Y +E D V +K Sbjct: 173 SIIHGKAWHEETKATASRAIGEDGNGHYLVVYNLEETDYVCNYIRYGGDKKEFLEKFKGA 232 Query: 161 -------------LSFMTQTTLSVDDTSD----VIDALRKRFPK----IVGPRKDDICYA 199 + QTT+ +T + + A+ R+ K D IC A Sbjct: 233 VSPGFDPDVHLCHVGVANQTTMMRGETEEVQRRICKAIEDRYGKENLHEHFRFFDTICGA 292 Query: 200 TTNRQEAVRAL--AEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD------- 250 T RQ+A+ + E+ ++++VVG NSSN++ LAE+ + + I +A+ Sbjct: 293 TQERQDALLDMLDKEKLDLLIVVGGYNSSNTSHLAEIGESR-LPTYFIKNAEKLISTRQI 351 Query: 251 -----------IQEEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 I E W+KE + VG+TAGAS P+ L++ + RL +L G L Sbjct: 352 QHWDLHKGQEVITEGWLKEGEINVGITAGASCPNNLIEETIQRLFELRGIGVETL 406 >UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga lettingae TMO RepID=ISPH_THELT Length = 278 Score = 269 bits (689), Expect = 9e-71, Method: Composition-based stats. Identities = 77/285 (27%), Positives = 149/285 (52%), Gaps = 15/285 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M+I++A GFC+GV RA+ + + + IY E+VHN+ VVDSLR+RG +++ Sbjct: 1 MRIIVAEDIGFCSGVRRALKMTLSEINE-NEKIYTLGEIVHNKTVVDSLRKRGVNVLQEN 59 Query: 60 -ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 I E + LI AHG+S+ E + + D TCP+V + +R + G ++ Sbjct: 60 IIPEDAKNSSLIIRAHGISRDQLFELQKVFKKIVDTTCPIVHNLFQTASRIHQEGYRIVV 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 G HPE+ G + ++ P+ ++ M+QTT+S+D+ D + Sbjct: 120 FGKESHPEMSALKGYVKD---ATITLKPPE--------LSGRICIMSQTTMSIDEFYDFV 168 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + +C T R++ + +A+Q ++++++G KNSSN+++L ++A + Sbjct: 169 VKSISQSKFSEIRIINTVCEITARREKEAQKIAKQVDLMIIIGGKNSSNTSKLTKIASKF 228 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 RA I+ +++ + +V+ +G+T G S P+ V+ V+ +++ Sbjct: 229 -TRAIQIETPEEVDKINFDKVEMIGITTGTSTPEEDVKTVIDKIK 272 Score = 40.8 bits (95), Expect = 0.070, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 40/96 (41%), Gaps = 1/96 (1%) Query: 89 LTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPD 148 + + + C + + E + +++ + I+IG S + +E+P+ Sbjct: 180 IRIINTVCEITARREKEAQKIAKQVDLMIIIGGKNSSNTSKLTKIASKFTRAIQ-IETPE 238 Query: 149 DVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKR 184 +V K+ E + T T+ +D VID ++ R Sbjct: 239 EVDKINFDKVEMIGITTGTSTPEEDVKTVIDKIKCR 274 >UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AAK2_GEMAT Length = 437 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 86/362 (23%), Positives = 134/362 (37%), Gaps = 75/362 (20%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFIE--- 58 I LA GFC GV+RA+ + I++ E++HN +V L+E G IF+ Sbjct: 73 IRLAREFGFCYGVERAVDYAYQTRRKFPERRIFLAGEIIHNPHVNAKLQEMGVIFLSAKG 132 Query: 59 ---QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + V ++I A GV+ + V D TC V V V +R G Sbjct: 133 KGFDYAPVEPKDVVILPAFGVTIQDFQTLRELGCVVVDTTCGSVLNVWKRVEAYARDGFT 192 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMY-LVESPDDVWKL--------------------- 153 S++ G H E T Q GG Y +V + + Sbjct: 193 SLIHGKYYHEETRATASQVEKYNGGQYLVVRDMAEAELVMDYLEDRAGVQPAREPLSREA 252 Query: 154 --------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR------- 192 + E++ QTT+ ++ + A+ + + G Sbjct: 253 FLERFAKAASDGFDPDVHLERVGVANQTTMLARESLAIGAAVGESMTRGYGEAHRAEHFR 312 Query: 193 -KDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD 250 D IC AT +RQ+AV L ++++VVG NSSN+ LA L + I D + Sbjct: 313 TFDTICSATQDRQDAVMELLRDPLDLMVVVGGYNSSNTISLAALCAEQ-VPTYHIADPDE 371 Query: 251 IQ--------------------EEWVK--EVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 I W+ +G+TAGAS P+ + VAR+ + G Sbjct: 372 IDVAENRVRYRRIGAKHHEDEMSSWLPTTGPLRIGITAGASTPNNKIGQAVARVFAIRGV 431 Query: 289 EA 290 +A Sbjct: 432 DA 433 >UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphate reductase protein n=1 Tax=Spiroplasma citri RepID=Q14P56_SPICI Length = 293 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 91/298 (30%), Positives = 152/298 (51%), Gaps = 18/298 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+++ PRG+C GV ++I + A Y G IY+ +VHN++V+D + G I + Sbjct: 1 MKVVKVTPRGYCLGVVKSIKWAKEAAIKYAGRQIYMLGYLVHNKHVIDEIVNLGVIPVND 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA-S 110 I +PD A++I SAHG +++ A +++T+ D C VT + + Sbjct: 61 FKLNRLELIQTLPDNAVVILSAHGSDDRIKDVAVQKNITLVDTECEWVTVTKNLIKEYLA 120 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTT 168 + + I IG HPE + + LV + +V + + +K+ QTT Sbjct: 121 KPDYQIIFIGKHFHPETNAMLALSP----TINLVTTEQEVVSILPNLDPTKKILITNQTT 176 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSN 227 LS D +++ L+ P K+D+C AT RQ AV +L +++LVVG + SSN Sbjct: 177 LSKIDIEAIVEKLKTLVPN-EIIFKNDLCNATLERQNAVLSLDPTTIDLLLVVGDERSSN 235 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + +L + +++G ++ I+D DIQ W+ CV VTAGAS P I+ V+ L+Q+ Sbjct: 236 TLKLVAMGEQIGIESYRINDKSDIQPTWLANKTCVAVTAGASTPSIIQLEVIRYLEQI 293 >UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=Q1ATX3_RUBXD Length = 410 Score = 261 bits (667), Expect = 3e-68, Method: Composition-based stats. Identities = 89/361 (24%), Positives = 147/361 (40%), Gaps = 69/361 (19%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI-- 57 + + LA+ GFC GVDRA+ + I++ +++HN + LRE G F+ Sbjct: 45 LTLRLADEFGFCYGVDRAVDYAFQTREKFPDRRIFLTGDMIHNASMNARLREMGIEFLSQ 104 Query: 58 -------EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 E+ ++ + ++I A G + + R + D TC V V VAR + Sbjct: 105 GFDGRPDERFEDLDEEDVVILPAFGAPVEWVGKLRERGCIIVDTTCGSVLSVWKRVARYA 164 Query: 111 RRGEESILIGHAGHPEVEGTMGQY--SNPEGGMYLVESPDDVWKL--------------- 153 ++G SI+ G H E T Q G +V + L Sbjct: 165 QKGFTSIIHGKYYHEETRATASQTRREGGNGKYLIVRDLKETGYLTDFIRGRTSAGELKE 224 Query: 154 -----------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KD 194 ++ ++ QTT+ + +T V + +RK + G D Sbjct: 225 RLGHGMSPGFDPERDLVRVGVANQTTMLMTETMKVGEEIRKAMEERYGRENLAEHFELFD 284 Query: 195 DICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLI-------- 245 IC AT +RQ+A+ L E +VV++VG NSSN+N LA +A R++ I Sbjct: 285 TICSATQDRQDALMRLLEHPLDVVVIVGGYNSSNTNNLAIIAAGRVPRSYHIANGECIRG 344 Query: 246 ------------DDAKDIQEE-WV-KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 D ++++EE W+ + VG+TAGAS P+ + V R+ + G Sbjct: 345 ASIRHKPPGTPLDPREEVEEEGWLPEGPVRVGLTAGASTPNSQIGLAVRRILEARGIRVE 404 Query: 292 P 292 Sbjct: 405 E 405 >UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IE33_THEAB Length = 811 Score = 260 bits (665), Expect = 5e-68, Method: Composition-based stats. Identities = 78/292 (26%), Positives = 140/292 (47%), Gaps = 21/292 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI +A GFC GV++A+++ + L G ++ ++VHN+ V++ L G + Sbjct: 1 MQIKIAKGIGFCFGVEKAVNVTKELLKS-GKNVFTDDDIVHNKQVMEELERLGLSY---- 55 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +G I + AHG+ + + K V D TC +V + V +G + ++ G Sbjct: 56 ---DNGDIYLIRAHGLPKEKIEKIKKEH-RVVDLTCNIVYNLFKTVEVYENKGYQVVVYG 111 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE+ N + +E V +K+ +QTT+S D + + Sbjct: 112 KITHPEMIALKSYSKN---AIITMEPL-------VIKSDKIFVASQTTMSYKDFENFYNK 161 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + IC T NR+ V L+++ ++++VVG K+SSN+ +L +A + Sbjct: 162 LKDISIYNEFKVFNSICNITHNREIEVEKLSKEVDLMIVVGGKHSSNTRKLFNIASQH-T 220 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 +A I+ +I+E K V VG+ +G S P +V+ + A L++LGG + Sbjct: 221 KAIHIETIDEIKEI-PKGVDSVGIISGTSTPKEIVEEIAAGLKKLGGMLQME 271 >UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2ASB2_STRRD Length = 420 Score = 260 bits (664), Expect = 6e-68, Method: Composition-based stats. Identities = 94/291 (32%), Positives = 154/291 (52%), Gaps = 4/291 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA R C G RA+ I + A G ++ V + + +L G + + Sbjct: 118 RVLLAGTRPACPGARRALEITRDT-AGGGQAVFSYGPVTDDPHQAGALTREGVTTVTDLD 176 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +P+GA ++F AHGVS A+R EA +R LT+ DATCPLV H EVAR + RG+ +++IG Sbjct: 177 RLPEGAGVVFPAHGVSLALRAEAAARGLTIIDATCPLVAAAHAEVARFTERGDLTVVIGR 236 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 +G V +GQ LVES DV +L + E +S++ QT + V+ + V+ AL Sbjct: 237 SGDAAVSAVLGQAP---ESTVLVESAADVERLRPADPEAISYLVQTGIPVEQATPVVAAL 293 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R RFP + GP D CY ++R AV ++ ++++L+ + ++ + LA+ G Sbjct: 294 RARFPALRGPDPGDFCYHASDRASAVASITGASDLLLIAAGSHCPDARHVVRLAEPAGVP 353 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 A ++ D+ + ++E V +T+ SAP L + +V L LG + Sbjct: 354 AQVVTGVADLCPDRLREAATVALTSARSAPAGLSEQIVTILSGLGPLGVVN 404 >UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Sphingobacteriales RepID=Q2S1D9_SALRD Length = 413 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 85/353 (24%), Positives = 142/353 (40%), Gaps = 70/353 (19%) Query: 4 LLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ--- 59 +A GFC GV++AI I AL I++ E++HN +V + LR+RG F+ Sbjct: 45 KIARHFGFCFGVEQAIEIAYEALEENPDKRIFLLSEMIHNPHVNEDLRDRGIQFLRTTQG 104 Query: 60 -----ISEVPDGAILIFSAHGVSQAVRNEAKSRDL--TVFDATCPLVTKVHMEVARASRR 112 E+ ++I A G + V + + + +D TCP V KV + ++ Sbjct: 105 EQLIPFDELTPDDVVIIPAFGTTLEVEQKLEEIGVDTEAYDTTCPFVEKVWRKSSQIGDD 164 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL------------------- 153 ++ G H E T EG + +V ++ +L Sbjct: 165 DHSIVVHGKRYHEETRATFSHAK-EEGPVVVVRDMEEAEELAKVIRGEKDADFFYDYFED 223 Query: 154 -------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK---------DDIC 197 ++ +KL + QTT+ ++T+ + D +R + G D +C Sbjct: 224 KYSEDFDPERDLQKLGVVNQTTMLAEETAAIADLMRDAMRERYGEAHVEERFADTSDTLC 283 Query: 198 YATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ---- 252 YAT Q A +AL E A++ +VVG NSSN++ L EL + + I DA + Sbjct: 284 YATNENQNATQALIEDGADLGIVVGGYNSSNTSHLVELCEEHM-PTYFIRDASEFDAPSE 342 Query: 253 --------------EEWVKEVKC---VGVTAGASAPDILVQNVVARLQQLGGG 288 ++W V +T+GAS PD L+ VV ++ Sbjct: 343 IHHFDVHAKEEVATDDWFPAEDTPVDVLLTSGASCPDALLDEVVRKIISWFPD 395 >UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM5_9BACT Length = 543 Score = 251 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 96/374 (25%), Positives = 149/374 (39%), Gaps = 84/374 (22%) Query: 2 QILLANPRGFCAGVDRAISIVENALA-IYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + LL + GFC GV AI LA G +++ E++HN +V + L+ RG +++ Sbjct: 159 EYLLPSHFGFCLGVQNAIERAYETLAANPGKRVFMLSELIHNPFVNEDLQARGLKYLQSD 218 Query: 61 SEVP---------------DGAILIFSAHGVSQAVRNEAKSRDLTV--FDATCPLVTKVH 103 VP D I+I A G + R L + +DATC LV KV Sbjct: 219 KGVPLIEEATGRPYWDGLSDADIVIIPAFGARDEDKLRLIERGLPIRQYDATCMLVEKVW 278 Query: 104 MEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYL--------------VESPDD 149 R +G ++ G A H E + T + + + +S ++ Sbjct: 279 KAARRYGEQGYTIVIHGKAEHEETKATFSNSAKYAPSVVIRDIKEASILGEVIRAKSKEE 338 Query: 150 VWKL-------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--- 193 +L K+ ++L+ + QTTL ++T +I L + + G Sbjct: 339 KQRLFEPFVSRASVGFDPSKDLDRLALVNQTTLLRNETLKIIAYLEETLAETYGEAHVKE 398 Query: 194 --------DDICYATTNRQEA-VRALAEQAEVVLVVGSKNSSNSNRLAELAQRM-GKRAF 243 D +CYAT Q+A +AL E + +VVG KNSSN+ +L L Q G+RAF Sbjct: 399 HLAMSSKGDTLCYATQVNQDALAKALDEDIDAAIVVGGKNSSNTFQLFRLCQERFGERAF 458 Query: 244 LIDDA------KDIQEEWV--------------------KEVKCVGVTAGASAPDILVQN 277 I +I+ KE V VT GAS PD ++Q Sbjct: 459 YIQSEANILSRDEIEHFIFPYNPGDPKQGVMETRAFLPEKERVKVLVTGGASCPDGILQQ 518 Query: 278 VVARLQQLGGGEAI 291 ++ R+ E I Sbjct: 519 IICRINGFHAPERI 532 >UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP Length = 306 Score = 250 bits (640), Expect = 4e-65, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 125/290 (43%), Gaps = 15/290 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALA-IYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 ++ + GFC GV +A+S E L +G P+Y ++VHNR VD L G I E Sbjct: 9 RVEIDPESGFCFGVIKAVSRAEEILRQEHGEPLYCLGDIVHNRAQVDRLESLGMRTIDHE 68 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVA----RASRRGE 114 Q S + + A +++ AHG A A + V DATCP+V ++ +V + + Sbjct: 69 QFSHLSN-ARVLYRAHGEPPASYTYAAENGIEVVDATCPVVLRLQQKVRQAYLQHANDDT 127 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 + ++ G GH EV G +GQ +G +V P D+ + + +QTT+ D Sbjct: 128 QIVIFGKPGHAEVNGLVGQ---TDGKAIVVREPKDLDLVDF--ARSIELFSQTTMQEDQL 182 Query: 175 SDVIDALRKRFPKIVGPR-KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +++ ++ R + IC + R +R A+ + + V + SSN L + Sbjct: 183 EEMLSLIQSRLSDTATLVSHNTICQQVSRRIPNIREFAKSHDRIFFVSDQKSSNGRVLYQ 242 Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEV-KCVGVTAGASAPDILVQNVVARL 282 + I ++ + V + +GV S +Q + + Sbjct: 243 NCLEVNPNTTFITYPSELTYDLVPSHEESIGVCGATSTSREQLQEIAEII 292 >UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HME7_FERNB Length = 854 Score = 239 bits (612), Expect = 6e-62, Method: Composition-based stats. Identities = 81/321 (25%), Positives = 146/321 (45%), Gaps = 25/321 (7%) Query: 4 LLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEV 63 ++ GFC GVD A+ + + L G ++ EVVHN+ V++ L+ G + Q Sbjct: 12 IIVGQYGFCFGVDNAVREIIDHLNK-GENLFTDGEVVHNKNVLEELKRLGLKYSPQ---- 66 Query: 64 PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAG 123 + + AHG+ NE S++ V D TCP+V + + S+ G + + G Sbjct: 67 -ENGTFVVRAHGLPPEKLNEI-SKNYKVIDLTCPIVQNLFALGKKLSKEGYKVVAFGKKD 124 Query: 124 HPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 H E+ G N LV + L + + K++ ++QTT S + + I+ ++K Sbjct: 125 HAEMVAFAGHVKNS-----LVTT----EPLPL-LDNKIAIISQTTSSSEKFALFIEEMKK 174 Query: 184 RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAF 243 + IC T R+E + LA+ V+VVG KNSSN+ +L E+A GK Sbjct: 175 LNKGKEIKVINTICKVTIEREEQAKKLAQICNFVVVVGGKNSSNTKKLFEIAYNYGKAVH 234 Query: 244 L--IDDAKDIQEEWVKEVK------CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG 295 + I++ +I+E +E +G+ +G S V++++ L + GG + +E Sbjct: 235 IESINEINEIEEMLFREKSKDIQTIKIGLISGTSTYSKDVEHILKYLVKNYGGRELYMED 294 Query: 296 REENIVFEVPKELRVDIREVD 316 + + ++E + Sbjct: 295 LNNLKQEVLEESFEQLLKEHE 315 >UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8P7_COPPD Length = 282 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 78/281 (27%), Positives = 127/281 (45%), Gaps = 18/281 (6%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++ LA P+G C GV R+I + L +G ++ H +VHN V+ L + G I E + Sbjct: 7 ELHLAFPQGPCFGVKRSIELCRKILEKHGT-VFAVHPLVHNEIVMADLAKHGLILEEDVE 65 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 ++P + ++ SAHG + V K ++ V DA CPLV VH + A + + ++G Sbjct: 66 KIPSNSWVVLSAHGTPKDVLERLKEKNCKVVDAVCPLVLFVHKKALEAVKNFGKVNIVGD 125 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 + H E+ + G Y++ P+ +++ + Q+T T + + Sbjct: 126 SQHQEIRALTSELP---EGSYVLCGPEGKLA-----DKRFPVVFQST-----TDPI---I 169 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 D IC AT RQ+A L E + ++++GS S+NS LA A GK Sbjct: 170 LHELDAEGYRIMDTICTATKGRQQANAQLIENCDALIILGSSTSANSRHLAAKASASGKP 229 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 L D + + VG+ AGAS P LV R+ Sbjct: 230 VLLTLDLDE-AASFALNYDIVGIIAGASTPLDLVYQAYDRI 269 >UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DRD7_9ACTO Length = 407 Score = 223 bits (568), Expect = 9e-57, Method: Composition-based stats. Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA +C G R + +VE+ L ++V ++ + +LRERG + + + Sbjct: 116 RVLLAGGEPWCVGGRRVVELVESTLDDGAELVHVVGDLAASPERRVALRERGVVPVTALD 175 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVPDGA ++ A G+ + R +A R + + D TCP + +V R + RG+ +L+G Sbjct: 176 EVPDGARVVVGAAGIPEEQRVKAAKRGVRIVDGTCPHIASGKAQVRRYAERGDAVVLVGQ 235 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E GQ + +VE+ DV ++ + + +S + ++++ ++ AL Sbjct: 236 RGHASTEALSGQAPD---ATLVVETTADVEQM--RGGDGVSAVPVPSMAIGAVVPMLAAL 290 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFPK+ D CY T +R VR LA A+VV V+G S + RL ++A Sbjct: 291 RRRFPKLPVQHPDQWCYQTQDRLATVRELAGTADVVFVLGPPESPETVRLLDVAAS---N 347 Query: 242 AFLIDDAKDIQEEWV 256 A + DI+ ++ Sbjct: 348 AVAVGGLGDIEPSYL 362 >UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium MedeBAC82F10 RepID=Q4PKE9_9BACT Length = 191 Score = 219 bits (560), Expect = 8e-56, Method: Composition-based stats. Identities = 83/192 (43%), Positives = 128/192 (66%), Gaps = 3/192 (1%) Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IGH GHPEVEGT GQ + + LV+ +DV KL +++K++++TQTTLSV DT +++ Sbjct: 2 IGHEGHPEVEGTAGQLQDI-SKLTLVQELNDVEKLYFPSDQKIAYITQTTLSVFDTQEIV 60 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 DAL K+FP+I+ P+K DICYAT+NRQ +VR +A+ + V+G+ NSSNS RL E A++ Sbjct: 61 DALEKKFPEILAPKKSDICYATSNRQTSVREMAKNVDAFFVIGAFNSSNSIRLVETAKKF 120 Query: 239 GK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 G + LI++ D + + + + +G+TA ASAP+ + + R+++ E I + + Sbjct: 121 GCEDSELIENIDDFDYQKLNQYQSIGLTASASAPEEQLNLFIDRVKENFSPEVIDFK-ED 179 Query: 298 ENIVFEVPKELR 309 ENIVF+VP L Sbjct: 180 ENIVFKVPNFLN 191 >UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase homolog n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=ISPH_BUCBP Length = 221 Score = 219 bits (560), Expect = 8e-56, Method: Composition-based stats. Identities = 80/215 (37%), Positives = 132/215 (61%), Gaps = 1/215 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+ILL NPR FC RA+SIV AL +G IYV H++VHN Y++++L+ +G IF + I Sbjct: 1 MKILLENPRSFCVETKRALSIVNLALKTWGKLIYVNHKIVHNNYIINNLKLKGVIFSKNI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + + + + L+ S H V ++ + + + DATCPLV KVH ++ ++ ILI Sbjct: 61 NSILESSKLMLSKHSVPNKIKKTTLEKKIFIIDATCPLVKKVHKKIHYKNKNTYNVILIE 120 Query: 121 HAGHPEVEGTMGQY-SNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 ++ HP+++GT+ +Y N + +Y+V+S KLT+KN Q TLS + +I Sbjct: 121 NSQHPKIQGTLERYQKNLKNSIYIVKSKKYAIKLTIKNTRNSIITAQITLSSEKIYPIIT 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQA 214 LRK+FP I+ +++ICYAT NR+ A++ ++++ Sbjct: 181 ILRKKFPAIINSHENNICYATINRKTAIKHISKKI 215 >UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V303_9AQUI Length = 167 Score = 204 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 50/166 (30%), Positives = 98/166 (59%), Gaps = 3/166 (1%) Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G GHPEV GT+G G +V + +++ K + K+ + QTT S D + + Sbjct: 2 GEHGHPEVIGTLGHLEESGGRGIVVSNMEELVK-NLPRTSKVGVVAQTTQSEDFFREAVG 60 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + + ++ + IC AT+ RQE V+ +A +V++++G K+S N+NRLA++++ + Sbjct: 61 YIAENIEEV--KIFNTICDATSVRQEEVKKIAPNVDVMIIIGGKHSGNTNRLAQISRYLN 118 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ A +I+ +W++ + +G++AGAS PD ++ VV ++++L Sbjct: 119 PDTYHIEKADEIEPKWLEGKEKIGISAGASTPDWIINEVVEKVKKL 164 >UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Beggiatoa sp. PS RepID=A7C5H7_9GAMM Length = 214 Score = 200 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 80/148 (54%), Positives = 110/148 (74%) Query: 138 EGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDIC 197 + M+++ +P++V L+VKN ++L+++TQTTLS+DDT DVI AL RFP I GP +DIC Sbjct: 2 DETMHVLCTPEEVMALSVKNPKQLAYVTQTTLSLDDTRDVIAALTTRFPNIKGPALNDIC 61 Query: 198 YATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVK 257 YAT NRQ AVR LA EV+LVVG+ NSSNSNRL E+ + G +A+LI+DA+D+Q +W Sbjct: 62 YATQNRQNAVRQLANDVEVLLVVGANNSSNSNRLREVGTQAGVQAYLIEDAEDLQPQWFA 121 Query: 258 EVKCVGVTAGASAPDILVQNVVARLQQL 285 VG+TAGASAP++LV+ V+ RL Sbjct: 122 NRPTVGITAGASAPEVLVEGVLQRLNNF 149 >UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D54C36 Length = 166 Score = 188 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 72/162 (44%), Positives = 112/162 (69%), Gaps = 1/162 (0%) Query: 149 DVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVR 208 DV L V++ + L+++TQTTLS+DDT V+ AL+K+FP I GP K+DICYATTNRQ AV+ Sbjct: 2 DVQNLEVRDTQNLAYVTQTTLSIDDTFSVVQALQKKFPAIQGPHKEDICYATTNRQLAVK 61 Query: 209 ALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR-AFLIDDAKDIQEEWVKEVKCVGVTAG 267 +A + + +LVVG+ NSSNS RL E+ +R G + + L+ A +I ++ ++ +G+TAG Sbjct: 62 EIANKIDALLVVGAPNSSNSKRLVEVGKRAGCKYSQLVQRASEIDFRALEGIENLGITAG 121 Query: 268 ASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 ASAP++L+ V+ ++ + +E EN+ F+VP+ LR Sbjct: 122 ASAPEVLIDEVINSFRETHLVDVEIVETAVENVNFKVPRVLR 163 >UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5KI36_9ALVE Length = 429 Score = 156 bits (396), Expect = 8e-37, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 111/303 (36%), Gaps = 84/303 (27%) Query: 54 AIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLT--VFDATCPLVTKVHMEVARASR 111 + ++ ++EV ++ + V E +DA V V R + Sbjct: 124 LVPVDPVNEVTP---VLERGYAVVNETYMELHFEHPHAWFYDA-------VWSSVERHKK 173 Query: 112 RGEESILIGHAGHPEVEGTMGQY------SNPEGGMYLVES--PDDVWKL---------- 153 SI+ G + H E T N + Y+ + + +L Sbjct: 174 GEYTSIIHGKSKHEETIATSSFADKYLILKNLKDAEYVCKFLLSKNKERLVNDFFEKFPA 233 Query: 154 --------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDIC 197 +K+ EK+ QTT+ +T+ + K ++ GP + IC Sbjct: 234 DRHSVGFDPLKDLEKVGVANQTTMLKGETALIAKLFEKTVLQLYGPEGLNEHFVAFNTIC 293 Query: 198 YATTNRQEAVRAL----AEQAEVVLVVGSKNSSNSNRLAELAQRMG----KRAFLIDDAK 249 AT +RQ+A+ L A + +++LVVG NSSN+ L E++ G RAF ID Sbjct: 294 DATQDRQDALYKLVTPTATKLDMMLVVGGFNSSNTEHLQEISVEAGGVKDHRAFHIDGPA 353 Query: 250 DIQE---------------------------EWVKEVK---CVGVTAGASAPDILVQNVV 279 I E +++ +GVT+GAS PD +++ + Sbjct: 354 RIDELRNTITHKPVETPPIEAARNHGLAVTHDFLPGNGEHITIGVTSGASTPDDVLEQSL 413 Query: 280 ARL 282 +L Sbjct: 414 QKL 416 >UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammaproteobacteria RepID=C0AZ30_9ENTR Length = 97 Score = 132 bits (332), Expect = 2e-29, Method: Composition-based stats. Identities = 61/94 (64%), Positives = 72/94 (76%) Query: 223 KNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 KNSSNSNRLAELAQR GK ++LID +DI E WV VGVTAGASAPDILVQ V+ RL Sbjct: 4 KNSSNSNRLAELAQRAGKPSYLIDSFEDIDESWVANANIVGVTAGASAPDILVQQVLERL 63 Query: 283 QQLGGGEAIPLEGREENIVFEVPKELRVDIREVD 316 + G + + L GREENIVFEVPKELR+D + ++ Sbjct: 64 KTFGADDVVELSGREENIVFEVPKELRLDYKVIE 97 >UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E01-6750 RepID=UPI000190F3D8 Length = 83 Score = 111 bits (278), Expect = 3e-23, Method: Composition-based stats. Identities = 67/83 (80%), Positives = 76/83 (91%) Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 +AQRMG+ AFLIDDA DIQE WVK+ CVGVTAGASAPDILVQNV+ARL++ GGGEA+ L Sbjct: 1 MAQRMGRTAFLIDDAADIQEAWVKDAACVGVTAGASAPDILVQNVIARLREFGGGEAVTL 60 Query: 294 EGREENIVFEVPKELRVDIREVD 316 EGREENIVFEVPKELRVD+REV+ Sbjct: 61 EGREENIVFEVPKELRVDVREVE 83 >UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CI73_9FIRM Length = 83 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 28/78 (35%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + +A GFC GV RA+ V + PIY ++HN VV L +G IE I Sbjct: 1 MNVKVAEHAGFCFGVRRAVDKVYELIESQEKPIYTLGPIIHNESVVGDLEAKGVKVIENI 60 Query: 61 SE---VPDGAILIFSAHG 75 + V DG ++I S+ G Sbjct: 61 EQLHSVRDGVVVIRSSRG 78 >UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KX15_9GAMM Length = 66 Score = 79.8 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 33/61 (54%), Positives = 39/61 (63%) Query: 251 IQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRV 310 I+E W+ VGVTAGASAP+ LVQ+VV LQ G E PL G ENI F +PK LR+ Sbjct: 2 IEEGWLTPESVVGVTAGASAPEALVQDVVTALQARGADEVTPLNGEPENITFSLPKGLRI 61 Query: 311 D 311 Sbjct: 62 P 62 >UniRef50_Q6LH35 Putative uncharacterized protein n=1 Tax=Photobacterium profundum RepID=Q6LH35_PHOPR Length = 304 Score = 75.5 bits (185), Expect = 2e-12, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 84/239 (35%), Gaps = 32/239 (13%) Query: 42 NRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTK 101 N L E G + ++++P+GA + + + A + K+ + V D CP V K Sbjct: 57 NP---KMLEELGVNVVPTVADLPEGAGVFVTGYDADYAELQQLKADGVPVIDRPCPWVRK 113 Query: 102 VHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNP--EGGMYLVESPDDVWKLT-VKNE 158 + ++ + +L+ H + +V+ + ++ +K Sbjct: 114 LRDQILSFDNESYQMVLVIDENH-----MVYDCFKNLIPSDAIIVQPQNFKERICHLKLS 168 Query: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKD---DICYATTNRQ---EAVRALAE 212 LS ++ T D + + + + +P + +C T Q E V + Sbjct: 169 RPLSLLSYTVFRRTDIEAMAEFILQEYPNQEHHLHNYKKTLCLWTK--QGLFEEVEDKCQ 226 Query: 213 QA--EVVLVVGSKNSSN-----SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGV 264 + V ++ SN + L + + +I+ DI + K +GV Sbjct: 227 SHRLDEVWII----CSNRGDRSTQSLIQQVEDSQAIPVIIEKVADIPSR--NDKKKIGV 279 >UniRef50_Q075K0 Plastid lyt B-like protein (4-hydroxy-3-methylbut-2-enyl diphosphate reductase) (Fragment) n=1 Tax=Prototheca wickerhamii RepID=Q075K0_PROWI Length = 189 Score = 69.4 bits (169), Expect = 2e-10, Method: Composition-based stats. Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGA-PIYVRHEVVHNRYVVDSLRE 51 ++LA GFC GV+RA+ I A Y +++ +E++H V + LR Sbjct: 95 VVLAEAYGFCWGVERAVQIAYEARHRYPEAEVHITNEIIHKPSVNERLRR 144 >UniRef50_Q7MUK6 LytB-related protein n=2 Tax=Bacteria RepID=Q7MUK6_PORGI Length = 316 Score = 62.8 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 75/189 (39%), Gaps = 14/189 (7%) Query: 49 LRERGAIFIEQISEVPDGA--ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 ++ G +++ +++P+G +++ + + + + + + D CP V K+ E Sbjct: 60 FKKLGVPYVKTYNDLPEGNDFVVVNTGYDSIVHEEKVLREKGVEILDKPCPFVRKLRKEF 119 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK-LTVKNEEKLSFMT 165 + + +L+ + H + M L++ + K L N + + F++ Sbjct: 120 EK-IDDSYQYVLLCESNH---IIIKNFATIFPRDMILIQMGNYKEKLLEQSNGKPMMFIS 175 Query: 166 QTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQ---EAVRALA----EQAEVVL 218 T + V D + K FP D C R + +R ++ ++ L Sbjct: 176 YVTFLKKHSIQVFDFINKTFPGKDHKMVDTQCMWAAGRLSPIDEIRNMSEDILKEVRYAL 235 Query: 219 VVGSKNSSN 227 ++GS S+N Sbjct: 236 LIGSPGSTN 244 >UniRef50_D2MHW9 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHW9_9BACT Length = 55 Score = 58.9 bits (142), Expect = 2e-07, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 29/49 (59%) Query: 261 CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 VG+++GAS P+++++ ++A+L+ LG +EE+ F P L Sbjct: 3 TVGISSGASTPEVIIEELLAKLKDLGASTFEEFSLKEESTKFPFPHSLE 51 >UniRef50_Q4E9V2 Hydroxymethylbutenyl pyrophosphate reductase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9V2_9RICK Length = 52 Score = 53.2 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 258 EVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE-GREENIVFEVPK 306 V+ +G+TAGASAPDILV ++ L+ E + G EN+ F++P Sbjct: 1 GVEKIGITAGASAPDILVDELMDYLKVSMNVEVSVMPGGIIENVQFKIPN 50 >UniRef50_Q5YBC4 Plastid ispH (Fragment) n=1 Tax=Helicosporidium sp. ex Simulium jonesi RepID=Q5YBC4_HELSJ Length = 113 Score = 50.9 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 39/107 (36%), Gaps = 25/107 (23%) Query: 222 SKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEE-------------------WVKEVK-- 260 S+ + G ++ +D A I E W+ K Sbjct: 9 GAESARGR----DGEMNGVASYWVDSAARIDVENNAIAHKTAHGRAGGVTQNWLTPGKPI 64 Query: 261 CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKE 307 CVGVT+GAS PD V+NV+ + ++ + E + + P E Sbjct: 65 CVGVTSGASTPDRSVENVLDCIFRIYDPSFQGIPVLEHDTALDRPSE 111 >UniRef50_C5IH56 At4g34350-like protein (Fragment) n=3 Tax=Solanum RepID=C5IH56_9SOLN Length = 106 Score = 48.9 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 15/29 (51%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGA 31 + LA GFC GV+RA+ I A + Sbjct: 78 VKLAEAYGFCWGVERAVQIAYEARKQFPT 106 >UniRef50_C5WLY1 Putative uncharacterized protein Sb01g009135 (Fragment) n=1 Tax=Sorghum bicolor RepID=C5WLY1_SORBI Length = 119 Score = 45.1 bits (106), Expect = 0.003, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 29/48 (60%), Gaps = 4/48 (8%) Query: 252 QEEWVK-EVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 +E W+ + +GVT+GAS PD +V++ + ++ ++ + L+G + Sbjct: 15 KENWLPFGLIKIGVTSGASTPDKVVEDALQKVFEI---KREELDGAPQ 59 >UniRef50_Q88MU9 Thiol:disulfide interchange protein DsbC n=21 Tax=Pseudomonadaceae RepID=Q88MU9_PSEPK Length = 260 Score = 44.3 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 11/74 (14%) Query: 47 DSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVF-DATCPLVTKVHME 105 + +G + I+ +P G ++++ A G +++ +TVF D TCP K+H E Sbjct: 109 EKTERQGI--AKLINGIPAGEMVVYPAKGETKS--------HITVFTDTTCPYCHKLHAE 158 Query: 106 VARASRRGEESILI 119 V +RRG E + Sbjct: 159 VPELNRRGIEVRYV 172 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 427 e-118 UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 420 e-116 UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 401 e-110 UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 401 e-110 UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2... 399 e-109 UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 392 e-108 UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C... 385 e-105 UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 384 e-105 UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 384 e-105 UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5... 383 e-105 UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 382 e-105 UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 381 e-104 UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium... 377 e-103 UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 376 e-103 UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 375 e-103 UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 370 e-101 UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 369 e-101 UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 369 e-101 UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7... 367 e-100 UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4... 366 e-100 UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organis... 362 7e-99 UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepI... 361 2e-98 UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 360 3e-98 UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 359 6e-98 UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 359 1e-97 UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 357 2e-97 UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 357 3e-97 UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 357 3e-97 UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 356 5e-97 UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candida... 355 1e-96 UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 355 1e-96 UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_P... 354 3e-96 UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2... 354 4e-96 UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 352 1e-95 UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 352 1e-95 UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 351 2e-95 UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3... 351 2e-95 UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 349 6e-95 UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 349 8e-95 UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 349 1e-94 UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostri... 348 2e-94 UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 347 2e-94 UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 347 4e-94 UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 346 7e-94 UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 344 4e-93 UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 343 4e-93 UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2... 342 7e-93 UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 342 9e-93 UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 342 1e-92 UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 340 3e-92 UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 339 7e-92 UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 338 1e-91 UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=5... 337 3e-91 UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 337 4e-91 UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 336 5e-91 UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 335 1e-90 UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1... 335 1e-90 UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 335 1e-90 UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1... 332 1e-89 UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collins... 331 2e-89 UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 331 2e-89 UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3... 331 2e-89 UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2... 330 3e-89 UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 328 1e-88 UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 328 2e-88 UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 328 2e-88 UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 327 3e-88 UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/rib... 327 3e-88 UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 326 6e-88 UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1... 326 7e-88 UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate ... 325 1e-87 UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 324 3e-87 UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 323 5e-87 UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 322 1e-86 UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1... 322 1e-86 UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1... 321 2e-86 UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 321 2e-86 UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 320 5e-86 UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerof... 317 4e-85 UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 316 5e-85 UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8... 315 1e-84 UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 314 3e-84 UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 314 3e-84 UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 314 3e-84 UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 313 5e-84 UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 313 6e-84 UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 311 2e-83 UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 310 3e-83 UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 310 3e-83 UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 309 9e-83 UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 308 1e-82 UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 308 1e-82 UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 307 3e-82 UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 307 3e-82 UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3... 301 2e-80 UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 299 7e-80 UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteri... 298 1e-79 UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate ... 298 1e-79 UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1... 298 1e-79 UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 298 2e-79 UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 297 3e-79 UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 294 2e-78 UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1... 294 3e-78 UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCM... 293 6e-78 UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipe... 292 8e-78 UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 290 5e-77 UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 289 1e-76 UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 288 1e-76 UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 288 2e-76 UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 287 4e-76 UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 286 7e-76 UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 283 4e-75 UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellu... 283 5e-75 UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 282 1e-74 UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 282 1e-74 UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 281 2e-74 UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 4e-74 UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 5e-74 UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 280 6e-74 UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 279 1e-73 UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax... 278 1e-73 UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 278 2e-73 UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 278 2e-73 UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudona... 277 3e-73 UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 T... 276 6e-73 UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 274 3e-72 UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 273 4e-72 UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2... 273 6e-72 UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 272 9e-72 UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 272 1e-71 UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 271 2e-71 UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q... 271 3e-71 UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 267 4e-70 UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 265 2e-69 UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reducta... 264 3e-69 UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphat... 262 1e-68 UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2... 260 6e-68 UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 259 9e-68 UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1... 257 3e-67 UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP 256 1e-66 UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 252 1e-65 UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 248 2e-64 UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyt... 241 3e-62 UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 224 3e-57 UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphat... 213 7e-54 UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphospha... 211 3e-53 UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1... 203 8e-51 UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 196 1e-48 UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate ... 184 3e-45 UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 172 1e-41 UniRef50_Q6LH35 Putative uncharacterized protein n=1 Tax=Photoba... 132 2e-29 UniRef50_Q7MUK6 LytB-related protein n=2 Tax=Bacteria RepID=Q7MU... 122 2e-26 UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammapr... 122 2e-26 UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate ... 99 2e-19 UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia... 99 3e-19 UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reducta... 72 3e-11 UniRef50_Q075K0 Plastid lyt B-like protein (4-hydroxy-3-methylbu... 68 3e-10 UniRef50_D2MHW9 Putative uncharacterized protein (Fragment) n=1 ... 59 2e-07 UniRef50_Q5YBC4 Plastid ispH (Fragment) n=1 Tax=Helicosporidium ... 57 9e-07 UniRef50_Q4E9V2 Hydroxymethylbutenyl pyrophosphate reductase (Fr... 52 4e-05 UniRef50_C5IH56 At4g34350-like protein (Fragment) n=3 Tax=Solanu... 48 4e-04 Sequences not found previously or not previously below threshold: CONVERGED! >UniRef50_A1TYZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=23 Tax=Proteobacteria RepID=ISPH_MARAV Length = 316 Score = 427 bits (1099), Expect = e-118, Method: Composition-based stats. Identities = 213/316 (67%), Positives = 255/316 (80%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI IV AL ++GAPIYVRHEVVHN++VVD+LR RGAIF++++ Sbjct: 1 MQIRLANPRGFCAGVDRAIEIVNRALDVFGAPIYVRHEVVHNKFVVDNLRNRGAIFVDEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPD ++IFSAHGVSQAV+NEA R L VFDATCPLVTKVHMEV R SR G E ILIG Sbjct: 61 GEVPDDKLVIFSAHGVSQAVQNEAARRGLKVFDATCPLVTKVHMEVMRYSRDGRECILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGG-MYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMGQY + GG +YLVE DV KL VK+ +LSF+TQTTLS+DDT+ VID Sbjct: 121 HHGHPEVEGTMGQYDHSNGGDIYLVEDEADVQKLEVKDPSRLSFVTQTTLSMDDTARVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALR +FP+I GPRKDDICYAT NRQ+AV+ LA +++LVVGS NSSNSNRL ELA+RMG Sbjct: 181 ALRAKFPQIEGPRKDDICYATQNRQDAVKQLAGDCDIMLVVGSPNSSNSNRLRELAERMG 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 A+LID+A I W+ K +GVTAGASAP++LV +V+ RL+ LGG E + + GREE+ Sbjct: 241 TPAYLIDEAAQIDPAWLYGKKAIGVTAGASAPEVLVADVIKRLKALGGEEPVEVSGREES 300 Query: 300 IVFEVPKELRVDIREV 315 IVF +PKELR+D E+ Sbjct: 301 IVFSMPKELRIDAVEL 316 >UniRef50_A5WCZ2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=187 Tax=Bacteria RepID=ISPH_PSYWF Length = 318 Score = 420 bits (1081), Expect = e-116, Method: Composition-based stats. Identities = 204/316 (64%), Positives = 257/316 (81%), Gaps = 1/316 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI LANPRGFCAGVDRAI+IV ALA + PIYVRHEVVHN++VV L RGA+F+E++ Sbjct: 1 MQIYLANPRGFCAGVDRAIAIVNEALARFEPPIYVRHEVVHNKFVVSDLANRGAVFVEEL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVPDG+I+IFSAHGVS+AV +EA+ RDLTVFDATCPLVTKVH+EVA+ +R +++LIG Sbjct: 61 HEVPDGSIVIFSAHGVSKAVEDEAERRDLTVFDATCPLVTKVHIEVAKFAREKMDAVLIG 120 Query: 121 HAGHPEVEGTMG-QYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 H GHPEVEGTMG + G ++LVE+ DV KL V + ++L+F+TQTTLS+DDT+ VID Sbjct: 121 HQGHPEVEGTMGRFSAQYGGEIHLVENEADVEKLEVSDPDRLAFVTQTTLSMDDTAVVID 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ALRK+FP I GPRKDDICYAT NRQ+AV+ LA++ EVVLVVGS NSSNSNRL ELA+RM Sbjct: 181 ALRKKFPNIQGPRKDDICYATQNRQDAVKDLAQRCEVVLVVGSPNSSNSNRLRELAERMN 240 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 +A+LID+A ++++EW V VGVTAGASAP+IL+Q V+ +LQQ GG L+G EEN Sbjct: 241 CKAYLIDNAGEMKKEWFAGVGAVGVTAGASAPEILIQEVLNQLQQWGGDLPDELKGIEEN 300 Query: 300 IVFEVPKELRVDIREV 315 + F +PKELR+ ++EV Sbjct: 301 VTFSLPKELRIPVKEV 316 >UniRef50_Q3JAD0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Proteobacteria RepID=Q3JAD0_NITOC Length = 320 Score = 401 bits (1031), Expect = e-110, Method: Composition-based stats. Identities = 175/317 (55%), Positives = 233/317 (73%), Gaps = 4/317 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA PRGFCAGV RAI IVE+AL IYGAPIYV HE+VHN++VV+ L+ RG IF E + Sbjct: 1 MKVTLAQPRGFCAGVVRAIDIVEHALEIYGAPIYVLHEIVHNQHVVEDLQRRGVIFTEDL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + +P G++ IFSAHGVS AV AK DL V DATCPLVTKVH++ + R+G+E I+IG Sbjct: 61 ASIPAGSVTIFSAHGVSTAVVETAKKNDLQVIDATCPLVTKVHLQAKKYYRQGDELIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HAGHPEVEGT G+ +G +Y+++S +V L VK+ E ++++TQTTLS+DDT DV+DA Sbjct: 121 HAGHPEVEGTRGRV---KGTVYVLDSVAEVENLAVKDPEHIAYVTQTTLSIDDTRDVVDA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+KRFPKI GP DDICYAT NRQ AVR ++++ +++LVVG++NSSNSNRL E+ ++ G Sbjct: 178 LKKRFPKIHGPGLDDICYATQNRQNAVREMSKKVDILLVVGARNSSNSNRLREVGEQNGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A LI DAKD+ W VG+TAGAS P+ILVQ V+ L+ G E + L+G +E+I Sbjct: 238 TAHLIQDAKDLDSSWFTSQSRVGITAGASTPEILVQGVLNELRSYGVEEVMDLDGVQESI 297 Query: 301 VFEVPKEL-RVDIREVD 316 F +P L R +R+ Sbjct: 298 SFRLPTMLPRAKLRQKQ 314 >UniRef50_Q12EY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=437 Tax=cellular organisms RepID=ISPH_POLSJ Length = 333 Score = 401 bits (1030), Expect = e-110, Method: Composition-based stats. Identities = 175/314 (55%), Positives = 240/314 (76%), Gaps = 3/314 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +ILLA PRGFCAGVDRAI IVE AL +GAPIYVRHE+VHN YVV+ L+ +GAIFIE++S Sbjct: 10 EILLAEPRGFCAGVDRAIEIVERALTKFGAPIYVRHEIVHNTYVVNELKAKGAIFIEELS 69 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP GA L+FSAHGVS+A+++EA++R +FDATCPLVTKVH+EVA+ + G E I+IGH Sbjct: 70 DVPPGATLVFSAHGVSKAIQDEARARGFQIFDATCPLVTKVHVEVAKLHKEGYEFIMIGH 129 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GHPEVEGTMGQ + G++LVE DV ++T E+L+ +TQTTLSVDD +++ A+ Sbjct: 130 KGHPEVEGTMGQL---DSGIHLVEDVADVARITPSQTERLAVVTQTTLSVDDAAEISAAV 186 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + RFP++ P++ DICYAT NRQ+AV+ L+ Q ++++VVGS SSNSNRL ELA ++G Sbjct: 187 KARFPQVREPKQQDICYATQNRQDAVKVLSPQVDILIVVGSPTSSNSNRLRELAAKLGTE 246 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 A+++DDA +++E W + VG+TAGASAP+ILV+ V+ R++ LG ++G EE I Sbjct: 247 AYMVDDASELRESWFEGKSRVGLTAGASAPEILVKQVIDRIRALGAVSVRKMDGIEETIK 306 Query: 302 FEVPKELRVDIREV 315 F +PK L+VD + Sbjct: 307 FPLPKGLKVDAQGH 320 >UniRef50_D2PN99 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Actinomycetales RepID=D2PN99_9ACTO Length = 358 Score = 399 bits (1025), Expect = e-109, Method: Composition-based stats. Identities = 158/313 (50%), Positives = 220/313 (70%), Gaps = 4/313 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +YG P+YVR E+VHN++VV +L+ RGAIF+++ Sbjct: 36 RVLLAAPRGYCAGVDRAVVAVEKALDLYGPPVYVRKEIVHNKHVVQTLQARGAIFVDETD 95 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G +IFSAHGV+ V EA +R L DATCPLVTKVH E R + + +LIGH Sbjct: 96 EVPEGETVIFSAHGVAPVVHQEAAARQLKTIDATCPLVTKVHHEAKRFAATDYDILLIGH 155 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ ++LV+ P DV + V++ EK+ +++QTTLSVD+T + + L Sbjct: 156 EGHEEVIGTSGEAP---EHIHLVDGPGDVPNVEVRDPEKVVWLSQTTLSVDETMETVRRL 212 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP + P DDICYAT NRQ AV+ LA A++++VVGS+NSSNS RL E+A G + Sbjct: 213 RERFPHLQDPPSDDICYATQNRQAAVKKLAADADLMIVVGSRNSSNSVRLVEVAVEHGAK 272 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+D A +I E W++ V VGVT+GAS P+ILV++V+ L G GE + EE++ Sbjct: 273 AGYLVDYADEIDEAWLEGVDSVGVTSGASVPEILVRDVLDWLAARGYGEVQEVTTAEESL 332 Query: 301 VFEVPKELRVDIR 313 F +P+ELR D++ Sbjct: 333 TFALPRELRTDLK 345 >UniRef50_A0LW20 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Bacteria RepID=ISPH_ACIC1 Length = 340 Score = 392 bits (1008), Expect = e-108, Method: Composition-based stats. Identities = 151/315 (47%), Positives = 219/315 (69%), Gaps = 4/315 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGV+RA+ VE AL +YG P+YVR ++VHN++VV L +GAIF+E+ Sbjct: 11 RVLLAQPRGYCAGVERAVDTVEKALELYGPPVYVRKQIVHNKHVVAELEAKGAIFVEEAD 70 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+G+I++ SAHGV+ +V +A+ R L DATCPLVTKVH E R + +G E +LIGH Sbjct: 71 EVPEGSIVVLSAHGVAPSVYEQARQRRLKTIDATCPLVTKVHQEARRFAEQGLEILLIGH 130 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 A H EV GT G+ + LV+ P++ + VK+ ++++++QTTLSVD+T ++ L Sbjct: 131 ANHEEVVGTTGEAP---SSITLVDGPEEAEHVQVKDPSRVAWLSQTTLSVDETLQTVEVL 187 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFP+++ P DDICYAT NRQ AV+ +A A++V+VVGS+NSSNS RL E+A G + Sbjct: 188 RRRFPQLIDPPSDDICYATQNRQAAVKRIAAIADLVIVVGSRNSSNSARLVEVALDSGAK 247 Query: 242 A-FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A +L+DDA +I E W+ V VGVT+GAS P+ LV V+A L + G ++ E + Sbjct: 248 ASYLVDDASEIDERWLDGVWTVGVTSGASVPESLVTGVLAWLAERGFDTVEEIDAERETL 307 Query: 301 VFEVPKELRVDIREV 315 VF +P ELR +++ Sbjct: 308 VFALPPELRRELKAR 322 >UniRef50_A6C516 LytB protein n=2 Tax=Planctomycetaceae RepID=A6C516_9PLAN Length = 310 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 149/309 (48%), Positives = 215/309 (69%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LANPRGFCAGV+ AI +E + I+G+ +YV HE+VHN+YVV+ +G F+E + Sbjct: 1 MKVILANPRGFCAGVNMAIECLEEVIRIFGSNVYVYHEIVHNKYVVNRFTNQGVTFVEAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEVP+ +IL+FSAHGVS +RN+A+ R++ DATCPLVTKVH E + + G ILIG Sbjct: 61 SEVPENSILVFSAHGVSPVIRNQARERNIRTIDATCPLVTKVHTEAIKYADAGYHIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ + L+E+P++V L +L+F+TQTTLSV++ VI + Sbjct: 121 HEGHDEVIGTMGEAP---ESITLIETPEEVAALEFPEGARLAFLTQTTLSVEEAGRVIRS 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L++++P I P K+DICYATTNRQEAV L + ++VLV+GS+NSSNS RL E+ + GK Sbjct: 178 LKEKYPAIESPPKEDICYATTNRQEAVSELVSRVDLVLVLGSQNSSNSKRLMEIGKTAGK 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 AFLID +++ EW + + + +TAGASAP+++VQ ++ L+ E R+E++ Sbjct: 238 PAFLIDGVEEVLPEWFDQAETILITAGASAPEVVVQELIQFLEDNYQAEVENAIVRKESV 297 Query: 301 VFEVPKELR 309 F +PKELR Sbjct: 298 RFPLPKELR 306 >UniRef50_Q8D2R2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Proteobacteria RepID=ISPH_WIGBR Length = 315 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 164/315 (52%), Positives = 238/315 (75%), Gaps = 2/315 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I LANPRGFCAGVDRAI+IV+NA+ IYG PIYV +EVVHN+YVV+SL++ G+IF+++I Sbjct: 1 MNIFLANPRGFCAGVDRAINIVKNAIEIYGPPIYVYNEVVHNKYVVNSLKKIGSIFVKKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP+ +ILIFSAHGVS+++ EA R L +FDATCPLV+KVH E+ RAS+ E I+IG Sbjct: 61 CDVPEKSILIFSAHGVSKSILKEANKRKLIIFDATCPLVSKVHHEIKRASKLRSEVIIIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+ GT+GQY+NP +++++S +++ KL +K+ L + TQTTLSVDDT+ +I A Sbjct: 121 HKNHPEIIGTIGQYNNPNKKVFVIQSIEEICKLKIKDPNNLFYFTQTTLSVDDTNKIIFA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++K++P I+ PRK DICYAT NRQ++++ + + +++ ++GSKNSSNSNRL E+A + GK Sbjct: 181 IKKKYPYIIEPRKKDICYATENRQKSIKKIIKLVDIIFIIGSKNSSNSNRLFEIANKSGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA--IPLEGREE 298 +++LID K+I++ W+ V +G+TAGASAP+ILVQ VV L+ ++G E Sbjct: 241 KSYLIDTYKEIKKSWLNGVNNIGITAGASAPEILVQQVVNYLKIFYKNSVNIYQVDGDIE 300 Query: 299 NIVFEVPKELRVDIR 313 F +PK+L + I+ Sbjct: 301 KTKFMIPKKLILKIK 315 >UniRef50_Q7ULU1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Bacteria RepID=ISPH_RHOBA Length = 319 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 156/309 (50%), Positives = 212/309 (68%), Gaps = 3/309 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA PRGFCAGV+ AI ++ L +G P+YV HE+VHN++VV + RE+GA+F++ I Sbjct: 4 MKIILAAPRGFCAGVNMAIDSLDLTLQKFGPPVYVYHEIVHNQFVVKTFREKGAVFVDTI 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EVP+G +L+FSAHGVS +R A++R L DATCPLVTKVH+E + ++ G ILIG Sbjct: 64 DEVPEGGVLLFSAHGVSPEIRKAAQARKLHALDATCPLVTKVHLEAIKYAKAGYTIILIG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GH EV GTMG+ + LVE DV +L + +L+++TQTTLSVDD VI Sbjct: 124 HEGHDEVLGTMGEAP---EAIVLVEDEADVDRLEFEPGTQLAYLTQTTLSVDDAGRVIRR 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR+RFP+I P KDDICYAT NRQEAV+ L E A+V++V+GS+NSSNS RL ELA GK Sbjct: 181 LRERFPEIHSPPKDDICYATQNRQEAVKLLREDADVIVVLGSQNSSNSQRLKELAAEQGK 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 RA L+D +D+ + + V +TAGASAP+ +VQ+ + L++ REE++ Sbjct: 241 RAMLVDGPQDLAVDQFSDDDRVLITAGASAPESVVQSTIDWLKENFDASVDTQVVREEDV 300 Query: 301 VFEVPKELR 309 F +PK LR Sbjct: 301 QFPLPKPLR 309 >UniRef50_C9RIQ9 Hydroxymethylbutenyl pyrophosphate reductase n=5 Tax=Bacteria RepID=C9RIQ9_FIBSS Length = 310 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 152/309 (49%), Positives = 218/309 (70%), Gaps = 3/309 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+LA PRGFCAGVDRAI +VE A+ +G PIYVRHE+VHN++VVD+L+++G +F++++ Sbjct: 3 KIVLATPRGFCAGVDRAIHVVEKAIEKFGTPIYVRHEIVHNKFVVDTLKDKGVVFVDELD 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+++IFSAHGV++ + EAK+R+L V DA+CPLV KVH R G ILIGH Sbjct: 63 QVPEGSVVIFSAHGVAEHIYEEAKARNLQVLDASCPLVLKVHFSAKRHYNAGRHIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EVEGT+GQ EG + L+ + +D + V +++L+++TQTTLSV +T +I+AL Sbjct: 123 AGHAEVEGTLGQLP--EGAITLIRNENDAETVDVPADKELAYITQTTLSVAETRKIIEAL 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 ++RFP I+GP D+CYAT NRQ AV L + +++LVVG+KNSSNS+RL EL G Sbjct: 181 KRRFPNIIGPEAGDLCYATGNRQAAVLELCSEVDMLLVVGAKNSSNSSRLMELGLEQGLP 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ-LGGGEAIPLEGREENI 300 + LI D D+ W + + VG+++GASAP++LVQ VV L++ E L EN Sbjct: 241 SHLIADVNDLDPAWFEGIDTVGISSGASAPEVLVQGVVDWLKEKFAPVEVENLVKLVENT 300 Query: 301 VFEVPKELR 309 F +PK L+ Sbjct: 301 KFNLPKALQ 309 >UniRef50_Q5PAE7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=17 Tax=Rickettsiales RepID=ISPH_ANAMM Length = 342 Score = 382 bits (983), Expect = e-105, Method: Composition-based stats. Identities = 155/308 (50%), Positives = 223/308 (72%), Gaps = 5/308 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY--GAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++++LA PRGFCAGV+RA+ +E+ + Y +Y HE+VHN +VV+S ++ G F+ Sbjct: 36 VEVILARPRGFCAGVERAVRTLESVASRYAGTREVYALHEIVHNLHVVNSFKKMGVKFVS 95 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + EVP+GA+L+FSAHGVSQ V+ E++ + LTV DATCPLVTKVH+E+ R + G + IL Sbjct: 96 ALHEVPEGAVLVFSAHGVSQQVKEESRRKGLTVVDATCPLVTKVHLEIQRYDKSGYQVIL 155 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +GH GH EVEG+MGQ SNP + LV++ DV + + + KL+++TQTTLS+DDT+++I Sbjct: 156 VGHKGHREVEGSMGQVSNP---VVLVQNVQDVQSIKIPSAAKLAYVTQTTLSMDDTAEII 212 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 AL+ RFP+IVGP DICYAT NRQ AV+A+++ +VVL +GSKNSSNSNRL +LA+ Sbjct: 213 SALKLRFPRIVGPDLRDICYATQNRQTAVKAMSQMVDVVLAIGSKNSSNSNRLLDLAKAQ 272 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 RA+LID ++I EW+ + +G+TAGASAP+ILVQ V+ L + ++G E Sbjct: 273 NARAYLIDSYRNIDLEWLIGARRIGITAGASAPEILVQEVIDYLGLHANLKVRTMDGVSE 332 Query: 299 NIVFEVPK 306 NI F++P+ Sbjct: 333 NITFKLPE 340 >UniRef50_A1TE06 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=210 Tax=cellular organisms RepID=ISPH_MYCVP Length = 337 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 164/309 (53%), Positives = 218/309 (70%), Gaps = 4/309 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRG+CAGVDRA+ VE AL +GAPIYVRHE+VHNRYVVD+L + GAIF+EQ Sbjct: 28 RVLLAEPRGYCAGVDRAVETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTD 87 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GAI++FSAHGV+ V EA +R L DATCPLVTKVH E R +R + +L+GH Sbjct: 88 EVPEGAIVVFSAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGH 147 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH EV GT G+ + + +V++PD V K+TV++ K+ +++QTTLSVD+T + + L Sbjct: 148 EGHEEVVGTAGEAPD---HVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDETMETVRRL 204 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK- 240 R++FP + P DDICYAT NRQ AV+A+A + E+V+VVGSKNSSNS RL E+A G Sbjct: 205 REKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKNSSNSVRLVEVALGAGAS 264 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 A L+D A DI W V VGVT+GAS P+ILV+ V+ RL + G P+ E + Sbjct: 265 AAHLVDYADDIDPAWFDGVTTVGVTSGASVPEILVRGVLDRLAEHGYDVVQPVTTANETL 324 Query: 301 VFEVPKELR 309 VF +P+E+R Sbjct: 325 VFALPREIR 333 >UniRef50_B2HKN9 LytB-related protein LytB2 n=3 Tax=Mycobacterium RepID=B2HKN9_MYCMM Length = 333 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 162/313 (51%), Positives = 215/313 (68%), Gaps = 7/313 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 +LLA+PR FCAGV RAI VE L P+YVR ++VHNR VV L++RGAIF++++ E Sbjct: 24 VLLASPRSFCAGVHRAIEAVERVLDRATGPVYVRKQIVHNRTVVAELQDRGAIFVDELDE 83 Query: 63 VPD----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +PD GA+++FSAHGVS AVR A R L V DATCPLVTKVH E AR + RG+ +L Sbjct: 84 IPDPPAPGAVVVFSAHGVSPAVRAAANGRGLEVVDATCPLVTKVHAEAARFAGRGDTVLL 143 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IGH GH E +GT+G N M LV++ DDV +L + + ++S++TQTTL+VD+T+DVI Sbjct: 144 IGHLGHEETDGTLGVAPN---SMLLVQNADDVTELDLPEDAQVSYLTQTTLAVDETTDVI 200 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 DALRKRFPK+ P +DICYATTNRQ AV A+ + + +LVVGS+NSSNS RL ELA+R Sbjct: 201 DALRKRFPKLAEPPTEDICYATTNRQRAVEAIVRRCDALLVVGSQNSSNSQRLVELARRR 260 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 G A+LID DI W+ +G+TAGASAP LV+ V+ L+ G + E Sbjct: 261 GTPAYLIDGPTDIDPHWLDSTATIGITAGASAPPRLVEQVIDALRLRGPINVVESPVTTE 320 Query: 299 NIVFEVPKELRVD 311 ++ F +P ++RV Sbjct: 321 SVRFALPPKVRVP 333 >UniRef50_B0BAX0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=14 Tax=cellular organisms RepID=ISPH_CHLTB Length = 307 Score = 376 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 144/308 (46%), Positives = 204/308 (66%), Gaps = 4/308 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+L +PRGFCAGV RAI VE AL +G PIYV+HE+VHNR+VVD LRE+GAIFIE + Sbjct: 3 KIILCSPRGFCAGVIRAIQTVEVALEKWGRPIYVKHEIVHNRHVVDKLREKGAIFIEDLQ 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP + +IFSAHGV ++R EA R L DATC LVTKVH V +++G ILIG Sbjct: 63 EVPRNSRVIFSAHGVPPSLREEATERGLIAIDATCGLVTKVHSAVKMYAKKGYHIILIGK 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+ G G+ + + +VE+ +V L ++ L ++TQTTLS+DD +D++ AL Sbjct: 123 RKHVEIIGIRGEAPD---QITVVENIAEVEALPFSAQDPLFYVTQTTLSMDDAADIVAAL 179 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 + R+P+I ICYAT NRQ A+R + Q + V V+G + SSNSNRL E+A+R G Sbjct: 180 KARYPQIFTLPSSSICYATQNRQGALRNILPQVDFVYVIGDRQSSNSNRLREVAERRGVT 239 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE-GREENI 300 A L++ ++ EE ++ +G+TAGAS P+ +VQ + +LQ+L +I ++ EE+ Sbjct: 240 ARLVNHPDEVTEEILQYSGNIGITAGASTPEDVVQACLMKLQELIPDLSIEMDLFVEEDT 299 Query: 301 VFEVPKEL 308 VF++PKEL Sbjct: 300 VFQLPKEL 307 >UniRef50_Q6MC97 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Chlamydiales RepID=ISPH_PARUW Length = 313 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 149/308 (48%), Positives = 208/308 (67%), Gaps = 3/308 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++LL+ PRGFCAGV+RAI VE AL ++G+PIYV+HE+VHNR+VV L+ +GAIFIE + Sbjct: 1 MKLLLSKPRGFCAGVERAIETVEKALLLWGSPIYVKHEIVHNRHVVQGLKTKGAIFIEDV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP GA LI+SAHGVS AVR +AK R L DATC LVT+VH V R + +G + ILIG Sbjct: 61 EDVPVGARLIYSAHGVSPAVREQAKKRQLIEIDATCGLVTRVHSAVKRYALQGYQIILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H H E+ GT G+ + +VES +DV L +++KL ++TQTTLS+DD ++ A Sbjct: 121 HHNHVEIIGTAGEAPD---VTTIVESVEDVKNLNFSSQDKLFYITQTTLSLDDVKEITQA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L ++P + ICYATTNRQ A+R + + ++VLVVG SSNSNRL E A G Sbjct: 178 LIVKYPHVETLPSSSICYATTNRQMALREITDLTDLVLVVGDPQSSNSNRLREAASTRGI 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 ++LI+D K+I EW+ + +G+TAGAS P+ +VQ + L +LG E + E++ Sbjct: 238 ESYLINDEKEIHPEWLLGKQVIGLTAGASTPEEIVQKCIQCLIELGVNEVEDIVYTHEDV 297 Query: 301 VFEVPKEL 308 VF++PK + Sbjct: 298 VFQLPKPI 305 >UniRef50_O67625 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Aquificales RepID=ISPH_AQUAE Length = 289 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 92/290 (31%), Positives = 159/290 (54%), Gaps = 5/290 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I++A GFC GV RA+ + E +L +Y ++HN V+ L+ G F Q E Sbjct: 4 IIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLGV-FPSQGEE 62 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 +G +I +HG+ + + L V DATCP V VH V + +R G +L+G Sbjct: 63 FKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVGEK 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPEV GT+G G +VE+ +D+ E++ + QTT + + +V+ + Sbjct: 123 NHPEVIGTLGYLRACNGKGIVVETLEDIG--EALKHERVGIVAQTTQNEEFFKEVVGEIA 180 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 ++ + IC AT+ RQE+V+ LA + +V++++G KNS N+ RL +++ + Sbjct: 181 LWVKEV--KVINTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNPNT 238 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 + I+ A+++Q EW + VK VG++AGAS PD +++ V +R+Q++ G+ + Sbjct: 239 YHIETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLVS 288 >UniRef50_C1F698 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F698_ACIC5 Length = 338 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 163/312 (52%), Positives = 227/312 (72%), Gaps = 3/312 (0%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LL PRGFCAGV RA+ IV AL +GAPIYVR E+VHNR+VV+ L E+GAIF+E I Sbjct: 21 KVLLLKPRGFCAGVVRAVDIVRIALETFGAPIYVRKEIVHNRFVVNELAEKGAIFVEDID 80 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +VP+G+ +I+SAHGVS AVR ++K R+L V DATCPLVTKVH+E + +R+G +LIGH Sbjct: 81 QVPEGSRVIYSAHGVSPAVRQQSKDRNLRVIDATCPLVTKVHVEAVKFARQGYSLVLIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 H E+EGT+G+ + +V S +V L V + +++++TQTTLS+D+ D+I+AL Sbjct: 141 RDHEEIEGTLGEAPD---VTTVVSSAAEVAALEVPDPNRVAYLTQTTLSLDEARDMIEAL 197 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +K+FP IVGP DICYAT NRQ AV+ +A QA++VLVVGS NSSNSNRL E+++ +G + Sbjct: 198 KKKFPNIVGPHSQDICYATENRQVAVKNVAHQADLVLVVGSNNSSNSNRLVEVSRNLGTK 257 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 +LID++K I+ EW++ V V VTAGASAP++LV++VV L G G +E EN+ Sbjct: 258 GYLIDNSKAIRPEWLEGVATVAVTAGASAPEVLVEDVVKYLGSKGFGSVEEVEVMPENVR 317 Query: 302 FEVPKELRVDIR 313 F +P E+ I+ Sbjct: 318 FGLPPEIVQAIQ 329 >UniRef50_C2BTX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTX4_9ACTO Length = 336 Score = 369 bits (947), Expect = e-101, Method: Composition-based stats. Identities = 147/335 (43%), Positives = 208/335 (62%), Gaps = 29/335 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA++ V+ AL +YG PIYVR E+VHN++VV +L GAIF+ ++S Sbjct: 3 KVLLASPRGYCAGVDRAVTAVQRALEVYGQPIYVRKEIVHNKFVVRTLAAAGAIFVNELS 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ ++FSAHGV+ +V EA+ R L V DATCPLV+KVH E R + G + ILIGH Sbjct: 63 EVPSGSRVVFSAHGVAPSVYAEAEQRGLEVIDATCPLVSKVHREARRYANEGYDIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVES-------------------------PDDVWKLTVK 156 GH EVEGT G ++++++ D + L+ Sbjct: 123 TGHEEVEGTSGVAP---EKIHVIDTDWIDTSESATTGTESADTTATGTPPADPLAGLSTD 179 Query: 157 NEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEV 216 + KL +++QTTLSVD T+ + L++RFP ++ P DDIC+AT NRQ AV+A+A+Q EV Sbjct: 180 PDAKLIWLSQTTLSVDQTAATVARLQRRFPGLISPPSDDICFATQNRQGAVKAMAQQCEV 239 Query: 217 VLVVGSKNSSNSNRLAE-LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILV 275 V+VVGS NSSNS RL E Q A+ I+ ++ +W +GVT+GAS P++LV Sbjct: 240 VIVVGSANSSNSVRLREVAVQAGAGAAYRIEGVHELNPDWFTGASTIGVTSGASVPEVLV 299 Query: 276 QNVVARLQQLGGGEAIPLEGREENIVFEVPKELRV 310 V+ L Q G E ++ +E F +PK LR Sbjct: 300 TEVLEWLAQHGFDEVQMVQTTQETTSFALPKPLRK 334 >UniRef50_A3DDC0 Hydroxymethylbutenyl pyrophosphate reductase n=7 Tax=Clostridiales RepID=A3DDC0_CLOTH Length = 694 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 98/303 (32%), Positives = 164/303 (54%), Gaps = 6/303 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV A+ V N L PIY ++HN VVD +G I+ I Sbjct: 1 MEIIVAKSAGFCFGVSNAVKTVNNLLENQKEPIYTYGPIIHNAQVVDLFTSKGVKKIDDI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E ++ AHGV+ + + + L + DATCP V K+H V S G + I++G Sbjct: 61 DEAEPNGHIVIRAHGVTPDIYKKISDKGLILEDATCPYVKKIHNLVKEKSEEGYKIIIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G G +N Y+V+S DDV K + EK+ + QTT++ + +V A Sbjct: 121 DRNHPEVIGINGWCNN---QAYIVDSVDDVEKFPTSD-EKVCVVAQTTITNEKWLEVNTA 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+K+F I + D IC AT+ RQ +A+ ++++++G KNSSN+ +L ++ ++ Sbjct: 177 LKKKFKNI--LKFDTICSATSRRQNEAEEIAKNVDMMIIIGGKNSSNTQKLYDICKKHCN 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 + I+ + D+ +K++K VG++AGAS PD +++ V+ ++ +L + + + I Sbjct: 235 LTYKIETSGDLPPVDIKKIKKVGISAGASTPDWVIEEVIKKMSELNKQGMVDILENDGEI 294 Query: 301 VFE 303 F Sbjct: 295 DFA 297 >UniRef50_A1HTW2 Hydroxymethylbutenyl pyrophosphate reductase n=4 Tax=Veillonellaceae RepID=A1HTW2_9FIRM Length = 655 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 98/297 (32%), Positives = 162/297 (54%), Gaps = 10/297 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA RGFC GV RAI I P+Y ++HN +V L E+G + + Sbjct: 1 MKIILAEYRGFCYGVKRAIETAY--ACIGQGPVYTLGPIIHNPQLVQRLSEQGVVMANTL 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++P G +I +HGV V ++A++R L V DATCP V K + + +G ++G Sbjct: 59 EQIPAG-RVIIRSHGVGPEVYDQARARSLEVVDATCPHVRKAQQAARQLAEKGYYVAVVG 117 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ + + +VE+P D L E+L + QTT + D + ++D Sbjct: 118 EPNHPEVKSIVAWAG---ERVTVVETPADAQNLPY--HEQLGVVAQTTFASDQFNTIVDI 172 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + +I IC AT RQ+A LA + +V++VVG KNS+N++RLAEL + G Sbjct: 173 LKTKCREIE--VSRTICTATDQRQQAAIKLARKVDVMVVVGGKNSANTSRLAELCRLQGC 230 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 + ++ A++++ +W V+ VG+TAGAS PD +++ V +++Q+ ++ E Sbjct: 231 PTYHVETAQELKIDWFTGVQTVGITAGASTPDWIIEEVYSKMQEFDQLLDQDMKPLE 287 >UniRef50_B3SF22 Malic enzyme (Fragment) n=2 Tax=cellular organisms RepID=B3SF22_TRIAD Length = 470 Score = 362 bits (931), Expect = 7e-99, Method: Composition-based stats. Identities = 147/296 (49%), Positives = 219/296 (73%), Gaps = 3/296 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +ANPRGFCAGV+RA+ IVE LA YGAP+YVRHE+VHNRYVV++L+ +GAIF+E+I Sbjct: 11 LEIFMANPRGFCAGVERAVEIVELTLAKYGAPVYVRHEIVHNRYVVENLKNKGAIFVEEI 70 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+PD A+ I+SAHGVS+ V NE++ + L + DATCPLV KVH++ + + G++ I+IG Sbjct: 71 AEIPDNAVTIYSAHGVSEKVENESRFKHLKIIDATCPLVKKVHLQAQKFEKVGDKIIIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H HPE+EGT G+ + +++VE+ DV K+ +E +S++TQTTLSVDDT ++IDA Sbjct: 131 HKNHPEIEGTSGRV---KREVFIVENIQDVEKIPFSKDESISYVTQTTLSVDDTKNIIDA 187 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ FP I GP +IC+AT NRQ+AV+ LA + + V+G+KNSSNSNRL ++A+ G Sbjct: 188 LKNAFPNIKGPELKNICFATQNRQDAVKQLASLVDTIFVIGAKNSSNSNRLRDIAENCGT 247 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 +AFL++ D + + +G+TAGASAP+ILV N++A+++++ + +EG Sbjct: 248 KAFLLNGETDDISDLLHNSTKLGITAGASAPEILVSNLIAKIKKMRDVKITHVEGT 303 >UniRef50_A7AME9 LytB protein, putative n=2 Tax=Piroplasmida RepID=A7AME9_BABBO Length = 419 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 139/316 (43%), Positives = 190/316 (60%), Gaps = 5/316 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L PRGFCAGV RAI VE A+ I+G PIYV+HE+VHN +V ++L+++G IFIE I Sbjct: 85 VFLLEPRGFCAGVRRAIETVEEAVRIFGPPIYVKHEIVHNEFVCNTLKKKGVIFIEDIET 144 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VP+G+IL+ SAHGV +V K R+L DA+CPLV KVH+ V + + G + ILIGH Sbjct: 145 VPEGSILVLSAHGVPPSVHEMVKKRNLVEIDASCPLVNKVHVYVRKKAEEGYKIILIGHK 204 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H E GT+G+ + +VE+ DDV +L + L + TQTTLSVDD + D L Sbjct: 205 SHVETIGTLGEAPD---VTTVVETVDDVDRLEYSRDTPLFYATQTTLSVDDCKIIKDRLL 261 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +RFP I ICYATTNRQ AVR ++VLVVGS SSN+NRL + A RA Sbjct: 262 ERFPWIETIPSGSICYATTNRQFAVRDACNFCDLVLVVGSSLSSNANRLVDTANLRNVRA 321 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI-- 300 LI +A I EE + + + + ++A AS PD L +VV +L I + + Sbjct: 322 HLIPNADAITEELIGDARKIALSASASTPDELTADVVKKLAVPPYNYNIEIYHSCDERVP 381 Query: 301 VFEVPKELRVDIREVD 316 + +P+ L + I+E D Sbjct: 382 KWRLPRNLELYIKEHD 397 >UniRef50_B8FLP4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FLP4_DESAA Length = 576 Score = 360 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 97/286 (33%), Positives = 153/286 (53%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC GV RA+ +V + P+Y ++HN V+ L E+G +E+I Sbjct: 1 MKITIAKTSGFCMGVRRAVEMVLDTANRVKGPVYTFGPLIHNPQVMHMLAEKGVEVLEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G ++ AHGV+ R ++ TV DATCP V KV + + G I++G Sbjct: 61 PEKGEG-TVLIRAHGVTPETRGRLEAAGFTVIDATCPRVIKVQRLLDKYQAEGYTPIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV G +G G Y+V S ++ L + EK + QTT ++++A Sbjct: 120 DADHPEVIGLVGHAR---GHAYVVRSREEA--LNLPKGEKAVLVAQTTQDQVLYLNILEA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R+RF +I + IC +T RQE R LA Q E ++VVG K+S N+ RLA++A G Sbjct: 175 VRERFDEI--KDFNTICDSTARRQEEARGLAHQVEAMVVVGGKSSGNTQRLAQIAAGSGV 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 F ++ K++ + ++ VG+TAGAS P+ +++ V + G Sbjct: 233 PTFHVETEKELDVTKFQGMEHVGITAGASTPNWIIRRVHQAVADPG 278 >UniRef50_D1BMA5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonella RepID=D1BMA5_VEIPT Length = 632 Score = 359 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 100/298 (33%), Positives = 159/298 (53%), Gaps = 11/298 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV RA+ + A G Y ++HN VV L ++G ++++ Sbjct: 1 MEIILAENHGFCYGVKRAVEMANEAANNDGKS-YTLGPIIHNPQVVGRLEDKGVSPVQEV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S++ +G +I +HGV A+ EA+ + L V DATCP V K + G +++G Sbjct: 60 SDIVEG-TMIIRSHGVGPAIYEEAEEKGLHVVDATCPYVKKAQQDAKSVIDEGMTLVILG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ +N ++E + KL V EK+ + QTT S + +ID Sbjct: 119 EKNHPEVKSINLWANNEG---IIIEDEESAQKLQV--VEKMGVVVQTTFSQFKFNSIIDI 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K+ + IC AT RQ + LA ++++V+G KNS N+NRLAE+ + +G Sbjct: 174 LEKKSKNL--KVFKTICNATQERQNSAVDLARNVDLMIVIGGKNSGNTNRLAEVCRDVGC 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + I+ + ++Q EW V+ VGVTAGAS PD +++ V+ ++ E + EG+EE Sbjct: 232 ATYHIETSTELQLEWFNRVQTVGVTAGASTPDWIIKEVIETMKDF--AELLAAEGQEE 287 >UniRef50_B5E9S9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_GEOBB Length = 283 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 102/290 (35%), Positives = 151/290 (52%), Gaps = 8/290 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ++LA GFC GV RA + A I G+ Y ++H+ VV L E G I ++ + Sbjct: 1 MQVILAKHAGFCFGVKRATQLAFQAANI-GSETYTLGPIIHSPQVVQRLEEMGVIPVDNV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SEV G +I +HGV+ A +L V DATCP V K VA S+ G + +++G Sbjct: 60 SEVETGGTIIIRSHGVAAEELEAAVRANLEVVDATCPFVKKAQEHVATLSKEGYDIVVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + G +Y+V S DV +L K+ + QTT S + +V+ A Sbjct: 120 DAVHPEVQGIVSYA---AGRVYVVSSHKDVERLP--RMSKIGVVAQTTQSFEHLHEVVAA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 R + IC AT RQE + LA + ++V+G NS+N+ RLA++ + Sbjct: 175 CLAR--GGEARVYNTICDATAVRQEEAKKLAGAVDCMVVIGGFNSANTMRLAQICLELLP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 R ++ A I E+W K VK VGVTAGAS P ++ V+ R+ + + Sbjct: 233 RTHHVETASQIDEQWFKGVKKVGVTAGASTPKWIIDEVIDRISAIDKDKI 282 >UniRef50_B8D8U8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=9 Tax=Bacteria RepID=ISPH_BUCA5 Length = 319 Score = 357 bits (918), Expect = 2e-97, Method: Composition-based stats. Identities = 171/308 (55%), Positives = 237/308 (76%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+L NPRGFCAGV RAI IVENAL +Y IY+RHE+VHN+YV+++LR++G +F+E+I Sbjct: 1 MNIILTNPRGFCAGVKRAILIVENALKVYKKTIYIRHELVHNQYVINTLRQKGVVFVEKI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++PD +++IFSAHGVS+ V EA + L + DATCPLV KVH+EV+++S + E+ILIG Sbjct: 61 EQIPDYSVVIFSAHGVSKKVVQEAVKKKLIILDATCPLVEKVHIEVSKSSEKAIETILIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H GHPEVEGT+GQY+N G +YLVES +DV L+V+N +KL+F TQTTLS+ +T +I A Sbjct: 121 HRGHPEVEGTIGQYNNKNGKIYLVESIEDVHNLSVQNSKKLNFFTQTTLSITNTKKIIAA 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ +FP+I GP K+DICYATTNRQ AVR L++ A+++ V+GS NSSNSNRLAEL + G Sbjct: 181 LKNKFPEISGPNKEDICYATTNRQIAVRQLSKIADIIFVIGSNNSSNSNRLAELGKETGT 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 LI DI+++W+K V +G+TAGASAP+ILV V+ L+++G + I + G E Sbjct: 241 FTKLISSFLDIKKKWLKNVNYIGITAGASAPEILVTEVIQYLRKIGAHKPIEMIGVREKK 300 Query: 301 VFEVPKEL 308 +F++PK+L Sbjct: 301 IFKIPKKL 308 >UniRef50_B3E441 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Desulfuromonadales RepID=ISPH_GEOLS Length = 280 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 96/286 (33%), Positives = 148/286 (51%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA + A + ++H+ VV+ L E G ++ + Sbjct: 1 MKVILAKRAGFCFGVKRATQMAFEAAGK-DQKTFTLGPIIHSPQVVNKLEEMGVGVVKDL 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 S V +G +I +HGV + +EA + L V DATCP V K V S G + +++G Sbjct: 60 SGVSNG-TVIIRSHGVLASEMDEAHQKQLEVVDATCPFVKKAQEHVQYLSEAGYDVLVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G + + +Y+V S D V +L K+ + QTT S D+ V+ Sbjct: 119 DADHPEVQGIVSY---GKEKVYVVASGDQVKQLP--KMGKMGVVAQTTQSFDNLKSVVTE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +R + IC AT RQ+ LA+Q + ++V+G NS+N+ RLAE+ + Sbjct: 174 CLRR--GGEVRVYNTICDATAVRQQEATELAQQVDCMIVIGGFNSANTRRLAEICTEIQP 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 R + I+ A +I W + V VGVTAGAS P ++ V+ RL Q+ Sbjct: 232 RTYHIETAAEIDCSWFQGVDTVGVTAGASTPKWIIDEVMNRLDQVN 277 >UniRef50_Q187C6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=7 Tax=Clostridiaceae RepID=ISPH_CLOD6 Length = 279 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 86/285 (30%), Positives = 155/285 (54%), Gaps = 6/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A GFC GV RA+ + + + + IY ++HN+ V E+G + +I Sbjct: 1 MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQAVAKYEEKGLKTVNEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P+ +I +HGV + + EAK + L + D TCP V K+H V+ +G E I+IG Sbjct: 61 DTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKIHTVVSEYHNKGYEIIVIG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G G N ++++ + + + N ++ + QTT++ + +++ Sbjct: 121 DMKHPEVIGINGWCEN---SAIIIKTLEQMENMEFDNSKRYCLVAQTTINPELYISIVNK 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +IV D IC AT RQE+ + LA++ + ++V+G K+SSN+ +L ++ + + Sbjct: 178 LSDKLEEIVF--NDTICSATKTRQESAKELAKEVDCMIVIGGKHSSNTQKLVKVCEDL-V 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ ++ +K+ K +G+TAGAS P+ +++ VV L+ L Sbjct: 235 PTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFLENL 279 >UniRef50_B0K9L0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Bacteria RepID=ISPH_THEP3 Length = 288 Score = 356 bits (915), Expect = 5e-97, Method: Composition-based stats. Identities = 95/292 (32%), Positives = 163/292 (55%), Gaps = 10/292 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+IL+A GFC GV RAI + G IY E++HN V+ L ++G IE+ Sbjct: 1 MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEE 60 Query: 60 --ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + ++ +G LI +HGVS+ + + + + V D TCP V KV V +G I Sbjct: 61 EELDKLTEGDKLIIRSHGVSKKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSII 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 ++G HPEV G G + Y+V S ++ ++L EK + QTTL D+ Sbjct: 121 IVGDRNHPEVIGVNGWCDDT---AYVVNSIEEAYELP--QLEKACAVAQTTLIEKHWKDI 175 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 ++ ++ + ++ + IC AT RQ+A L+++ +V+ V+G K+SSN+ +L ++ ++ Sbjct: 176 LEVIKLKVKDLIF--FNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEK 233 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 K F I+DA+++ E VK+ + +GVTAGAS PD ++++V+ +++ L G + Sbjct: 234 NCKNTFHIEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGED 285 >UniRef50_Q1Q304 Putative uncharacterized protein n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q304_9BACT Length = 584 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 84/302 (27%), Positives = 160/302 (52%), Gaps = 10/302 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY--GAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 +++ +A GFC GV RA+ I+ +A GA +Y ++HN V++ L +R + Sbjct: 5 LKVFVAKTAGFCMGVRRAMDILLDAANEKNIGAKVYTDGPLIHNPQVLEYLEKRDLHIVN 64 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 ++++ + + ++ AHGV+ + R E +S+ V DATCP V +V + + + +G +I+ Sbjct: 65 DVTDLSN-STVVIRAHGVTPSRRAEIESKGAKVCDATCPHVMRVQSIIKKYAAQGYSTII 123 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G GH EV G +G EG ++VE+ +++ L +K+ + QTT I Sbjct: 124 VGDNGHAEVVGLLGYA---EGRGHVVENMENIELLP--PMDKVCIVAQTTQDRHLFKRAI 178 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 D +++R+P + IC +T RQ+ V L + + ++VVG + S+N+ RL + + Sbjct: 179 DEIKRRYPNSES--FETICSSTYKRQDEVVNLCKSVDAMIVVGGRGSANTTRLVTICESQ 236 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 G F ++ +I +K +GVTAGAS P+ +++ VV +++ + + + Sbjct: 237 GTPTFHVETDSEIDLNKLKVFNTIGVTAGASTPNWMIKRVVDKVRTYKVNKYQKILFATK 296 Query: 299 NI 300 +I Sbjct: 297 SI 298 >UniRef50_Q8G4L8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=ISPH_BIFLO Length = 352 Score = 355 bits (911), Expect = 1e-96, Method: Composition-based stats. Identities = 145/328 (44%), Positives = 206/328 (62%), Gaps = 22/328 (6%) Query: 3 ILLANPRGFCAGVDRAISIV-----------ENALAIYGAPIYVRHEVVHNRYVVDSLRE 51 ++LA+PRGFCAGVDRAI V + P+YVR ++VHN++VV+ L Sbjct: 27 VVLADPRGFCAGVDRAILTVQTILKAAEASGKRTREDGLPPVYVRRQIVHNKHVVEDLAG 86 Query: 52 RGAIFIEQISEVPD-----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 +GA+F+++++E+PD G ++FSAHGVS V+ EA+ R + V DATCPLV KVH EV Sbjct: 87 QGAVFVQELAEIPDAAAQAGIPVVFSAHGVSPVVKAEAERRGMHVVDATCPLVGKVHREV 146 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQ 166 R R G E + IGH GH E G +G+ ++L+E DV L + KL ++Q Sbjct: 147 LRFVREGYEIVYIGHKGHDEAVGVVGESP---EHVHLIEHESDVDSLDFAPDTKLVLLSQ 203 Query: 167 TTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSS 226 TTLSVD+T+D I AL+ +FP I P DICYAT+NRQ AV+ +A+Q++ V++VGS NSS Sbjct: 204 TTLSVDETADTIAALKAKFPWIQEPPSSDICYATSNRQAAVKLVAQQSDCVVIVGSANSS 263 Query: 227 NSNRLAELAQR---MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 NS RL E+AQ +A+ +DDA ++ W + ++ VG+++GAS PD LV V+ LQ Sbjct: 264 NSVRLMEVAQEGLGERGKAYRVDDASELDPAWFEGLESVGISSGASVPDELVSGVIDALQ 323 Query: 284 QLGGGEAIPLEGREENIVFEVPKELRVD 311 LG +E +EN+ F +P ELR Sbjct: 324 NLGFTGMKSVETIKENMHFVLPAELRRK 351 >UniRef50_Q8I295 LytB protein n=9 Tax=Aconoidasida RepID=Q8I295_PLAF7 Length = 535 Score = 354 bits (908), Expect = 3e-96, Method: Composition-based stats. Identities = 126/316 (39%), Positives = 187/316 (59%), Gaps = 5/316 (1%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + L NPRGFC GV RAI VE L ++ PIYV+H++VHN V L + GAIFIE +++ Sbjct: 222 LYLINPRGFCKGVSRAIETVEECLKLFKPPIYVKHKIVHNDIVCKKLEKEGAIFIEDLND 281 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 VPDG ILI+SAHG+S +R AK + L DATCPLV KVH+ V ++ + ILIG+ Sbjct: 282 VPDGHILIYSAHGISPQIREIAKKKKLIEIDATCPLVNKVHVYVQMKAKENYDIILIGYK 341 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 H EV GT + + ++VE+ +DV KL +KL ++TQTTLS+DD + ++ L+ Sbjct: 342 NHVEVIGTYNEAPH---CTHIVENVNDVDKLNFPLNKKLFYVTQTTLSMDDCALIVQKLK 398 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 +FP I ICYATTNRQ A+ + + ++ +VVGS +SSN+ +L +Q A Sbjct: 399 NKFPHIETIPSGSICYATTNRQTALNKICTKCDLTIVVGSSSSSNAKKLVYSSQIRNVPA 458 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA-IPLEGREENI- 300 L++ D+ ++ +K V + +T+ AS P+ Q V L +G EN+ Sbjct: 459 VLLNTVHDLDQQILKNVNKIALTSAASTPEQETQKFVNLLTNPPFNYTLQNFDGAHENVP 518 Query: 301 VFEVPKELRVDIREVD 316 +++PK L I+E + Sbjct: 519 KWKLPKNLLHMIKERE 534 >UniRef50_A8ZT29 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZT29_DESOH Length = 577 Score = 354 bits (908), Expect = 4e-96, Method: Composition-based stats. Identities = 90/284 (31%), Positives = 146/284 (51%), Gaps = 8/284 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV RA+ +V +A Y PIY ++HN V+ L E+ +E I Sbjct: 1 MKVSIAKTSGFCMGVRRAVDMVLDASNRYTEPIYTFGPLIHNPQVLRLLAEKKISVMETI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E +G I++ AHGV R + ++ TV DATCP V KV ++R + G I+IG Sbjct: 61 PEQGNG-IVLIRAHGVPPRTREKLEAAGFTVIDATCPRVVKVQTIISRNAAEGCAVIIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G + + +S + + L EK + QTT S +V Sbjct: 120 DKDHPEVVGLLGYAGD---RGVVADSLEALKALPAF--EKAIIVAQTTQSTRLFDEVGAW 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 P + IC +T NRQ ALA Q + ++VVG NS N+ RLA+++++ G Sbjct: 175 AAAHHPH--YQVFNTICPSTKNRQAETEALARQTDAMVVVGGYNSGNTQRLAQVSKKSGH 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 F ++ ++++ + + +G+TAGAS P+ +++ + L+ Sbjct: 233 PVFHVETSEELDTNALAKSDHIGITAGASTPNWIIKKIYRELEA 276 >UniRef50_B2S9W9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=83 Tax=Alphaproteobacteria RepID=ISPH_BRUA1 Length = 346 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 152/313 (48%), Positives = 212/313 (67%), Gaps = 6/313 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I L PRGFCAGVDRAI IV AL YGAP+YVRHE+VHNRYVV+ L+ RGAIF+E++ Sbjct: 8 LEIRLCGPRGFCAGVDRAIQIVVLALKKYGAPVYVRHEIVHNRYVVEGLQARGAIFVEEL 67 Query: 61 SEVPD---GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+P ++FSAHGV ++V +A++++L DATCPLV+KVH + R R G I Sbjct: 68 DEIPAAHRNQPVVFSAHGVPKSVPADAEAKNLFYLDATCPLVSKVHKQAMRHQRLGRHVI 127 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 LIGH+GHPEV GTMGQ + G + L+E+ +D +E+ L F+TQTTLSVDDT+ + Sbjct: 128 LIGHSGHPEVIGTMGQLPD--GAVTLIETVEDAHTCHFDDEDNLGFVTQTTLSVDDTAGI 185 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I L+ RFP + P + ICYATTNRQ+AVRA A ++ L+VG+ NSSNS RL E+A++ Sbjct: 186 IKELQARFPNLAAPAAESICYATTNRQDAVRAAAPGCDLFLIVGAPNSSNSKRLVEVAEK 245 Query: 238 MGKR-AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 G R + L+ A+DI+ E + ++ VG++AGASAP+I+V ++ + + E Sbjct: 246 AGARMSMLVQRAEDIEWEQIGDISVVGLSAGASAPEIIVDEIIDAFKARFDVKIELAETT 305 Query: 297 EENIVFEVPKELR 309 E F V +E+R Sbjct: 306 VETENFLVNREIR 318 >UniRef50_A1A2C9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bifidobacterium RepID=A1A2C9_BIFAA Length = 343 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 153/334 (45%), Positives = 210/334 (62%), Gaps = 28/334 (8%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYG-------APIYVRHEVVHNRYVVDSLRERGA 54 +I+LA+PRGFCAGVDRAI V L P+YVR ++VHN++VV+ L +GA Sbjct: 13 RIVLADPRGFCAGVDRAILTVRTILKSADTPRADGLPPVYVRRQIVHNKHVVEDLAAQGA 72 Query: 55 IFIEQISEVPD-----GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA 109 +F+++++E+PD G ++FSAHGVS AV+ EA +R + V DATCPLV+KVH EV R Sbjct: 73 VFVQELAEIPDAAAEAGIPIVFSAHGVSPAVKAEATARGMHVVDATCPLVSKVHREVLRF 132 Query: 110 SRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTL 169 + G E I IGH GH E G + + ++L+E DV L + + KL +TQTTL Sbjct: 133 VKEGYEIIYIGHKGHDEAVGVVEESP---EHVHLIEHASDVDSLDFQPDTKLVLLTQTTL 189 Query: 170 SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSN 229 SVD+T+ I AL+ RFP + P DICYAT+NRQ AV+ +AEQA+ V++VGS NSSNS Sbjct: 190 SVDETAGTITALKARFPWLEMPPNSDICYATSNRQAAVKLVAEQADCVVIVGSANSSNSV 249 Query: 230 RLAELAQR-------------MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQ 276 RL E+AQ RA +DDA ++ W + V+ VG+++GAS PD LV Sbjct: 250 RLMEVAQEGLSARYASKTAVGAAGRAHRVDDASELDPAWFEGVESVGISSGASVPDELVS 309 Query: 277 NVVARLQQLGGGEAIPLEGREENIVFEVPKELRV 310 VVA LQ+LG + +E +EN+ F +P ELR Sbjct: 310 GVVAALQELGYQDVSTIETIKENMHFVLPAELRK 343 >UniRef50_Q2LUA5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LUA5_SYNAS Length = 577 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 94/288 (32%), Positives = 157/288 (54%), Gaps = 11/288 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M + LA GFC GV RA+ V + G IY ++HN V+ LRERG I I+ Sbjct: 1 MSVFLAKTAGFCMGVKRAVDTVLDIARHKGSEKIYTYGPLIHNPQTVEFLRERGIIPIKD 60 Query: 60 ISEV---PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 I + A ++ AHG+S + R + +++ L + DATCP VT V + + + + Sbjct: 61 IEALSASDQNAAIVIRAHGISPSERKKIRNKGLRIIDATCPKVTHVQAIIRQHAAKDYNI 120 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 ++IG HPEV G + G ++ S +V +L + EK+ + QTT +V++ + Sbjct: 121 LIIGDGDHPEV---NGLLGHAGGHGRVIGSLQNVEELPI--MEKVCVVAQTTQNVEEYAA 175 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 ++ +R RFP+ V + IC +T RQ VR LA + E +++VG +NS+N+ RLA L+ Sbjct: 176 IVRRIRDRFPETV--VFNTICDSTEQRQAEVRELAARMEAMVIVGGRNSANTRRLAALSS 233 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + G F I+ A ++ + + +G++AGAS P+ ++ VV R+ + Sbjct: 234 QQGTPTFHIETADELNDAKLAPYDRIGLSAGASTPNWIIDRVVDRIAE 281 >UniRef50_A4J3N5 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridia RepID=A4J3N5_DESRM Length = 672 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 96/305 (31%), Positives = 164/305 (53%), Gaps = 10/305 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RAI + + IY ++HN VV +L E G I I Sbjct: 1 MRIKLASKAGFCYGVKRAIDLALSTAKEKAGNIYTLGPLIHNPQVVQNLAENGICEINDI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV +G +I +HGV + A+ + L V DATCP V + + +G ++G Sbjct: 61 GEVKEG-TVIIRSHGVGPEIIQAAREKGLKVLDATCPFVARAQKYAHEMAAQGIPVYILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEV+G +G EG ++++P ++ ++ K+ + QTT + + +++A Sbjct: 120 DPGHPEVQGILGW---TEGKGSVIDNPSEITRVEHP---KVGVVAQTTQPLSNFQALLEA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + + ++ IC+AT RQ A LA + +V++VVG KNS+N+ +LA++ Q G Sbjct: 174 LQNQ--GVEVDARNTICHATGERQRAAMELAREVDVMVVVGGKNSANTKKLAKICQETGT 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 + ++ A+++++EW + VG+TAGAS PD +++ V R+ ++ EG E + Sbjct: 232 PTYHVESARELRKEWFLGHEIVGLTAGASTPDAIIEEVKKRMNEMDQMTNGE-EGMSEAM 290 Query: 301 VFEVP 305 + P Sbjct: 291 EVKSP 295 >UniRef50_Q2GDX3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Neorickettsia RepID=ISPH_NEOSM Length = 303 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 134/307 (43%), Positives = 211/307 (68%), Gaps = 8/307 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 MQI +A PRGFCAGV+RAI VE A+ Y I+V HE+VHN V+ + RG FIE Sbjct: 1 MQIFVACPRGFCAGVERAIETVEIAIRRYPEKKIFVYHEIVHNSRVIQDFKARGVDFIED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I++V ++LIFSAHGVS+ + KS DL + DATCPLV+K+H EV R + G ++I Sbjct: 61 ITKVEPKSVLIFSAHGVSEEIEKYVKSLDLVLVDATCPLVSKIHREVQRFEKEGFIILVI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G+ H E+ GT+G+ + Y+V+ P+D+ L KL+++TQ+TL+++ TS +I+ Sbjct: 121 GNRNHAEIIGTVGR---TKTQAYIVQDPEDIDNLP-SITGKLAYVTQSTLALEYTSTMIN 176 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 ++++FP +VG D+CYAT NRQEAV+ALA++ +++L+VGS NSSNS L +++ ++ Sbjct: 177 KIKEKFPNVVGRS--DVCYATQNRQEAVKALAKEVDLMLIVGSTNSSNSRNLMQVSSKIC 234 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG-GEAIPLEGREE 298 ++AFLID+ +++ +W + V VG+++GASAP+ILVQ++V+ L++ E + +EE Sbjct: 235 QKAFLIDNYNEVEPDWFEGVDRVGISSGASAPEILVQDLVSFLKKRFPSAEVSDFKFKEE 294 Query: 299 NIVFEVP 305 + F++P Sbjct: 295 KVQFKLP 301 >UniRef50_C2KTB4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Mobiluncus mulieris RepID=C2KTB4_9ACTO Length = 374 Score = 349 bits (896), Expect = 8e-95, Method: Composition-based stats. Identities = 139/375 (37%), Positives = 206/375 (54%), Gaps = 70/375 (18%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA+PRG+CAGVDRA+++V+ AL +GAP+YVR E+VHN++VV +L GA+F+ ++ Sbjct: 3 KVLLASPRGYCAGVDRAVTVVQRALERFGAPVYVRKEIVHNKFVVRTLAAAGAVFVSELH 62 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP G+ +IFSAHGV+ AV EA++R L V DATCPLVTKVH E R + +G + ILIGH Sbjct: 63 EVPSGSRVIFSAHGVAPAVYAEAEARGLKVIDATCPLVTKVHREAKRFADQGYDIILIGH 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------------- 153 GH EVEGT G + + ++++ DV L Sbjct: 123 QGHEEVEGTQGVAPD---RIRVIDTNQDVSILTGNQPETPGENPAPSPKERQDFGLAPGE 179 Query: 154 ---------------TVKNEEKLSFMTQTTLSVDDTS----------------------- 175 + E ++ + T + D T Sbjct: 180 SSPNPARNVVPGSQPELAPHESVNHVNHETAATDATDSATNGKRKMVWLSQTTLSVDQTN 239 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 + + L+ FP + P DIC+AT NRQ AV+A++ + +VV+VVGS NSSNS RL E+A Sbjct: 240 ETVARLKLHFPGLESPPSGDICFATQNRQGAVKAMSPKCDVVIVVGSANSSNSVRLMEVA 299 Query: 236 QRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE 294 + G ++ +D A ++ +W + K VG+T+GAS P++LV V+ L G + P+E Sbjct: 300 REAGAGASYRVDGAGELCADWFEGAKTVGLTSGASVPEVLVDEVLQWLAAHGFDDVEPVE 359 Query: 295 GREENIVFEVPKELR 309 EE F +P++LR Sbjct: 360 TLEETTRFALPRDLR 374 >UniRef50_B8G2Q3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Desulfitobacterium hafniense RepID=B8G2Q3_DESHD Length = 661 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 90/298 (30%), Positives = 154/298 (51%), Gaps = 11/298 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+ A GFC GV RA+ + E + ++HN+ VV+ + ++G + ++ Sbjct: 1 MKIIRAEKAGFCFGVKRALDMAERTVQSSSTA--SLGPLIHNQQVVEKMEKQGVRVVGEV 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G LI +HGV + EA+ + V DATCP V K A +S+ G + +++G Sbjct: 59 KETQAGDTLIIRSHGVPPDIYEEARRCQVKVVDATCPFVQKAQRLAAESSQSG-QVVVVG 117 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G G +E+ ++ +L E+LS + QTT + ++D Sbjct: 118 DRQHPEVQGILGWAG---GNAIAIETLEEARELPFY--EQLSVLAQTTQPAANFHGIVDE 172 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + + IC AT RQ R LA + +V++VVG KNS+N+ +LA + Sbjct: 173 LKTHTHAL--KVHNTICNATEERQTVARELAGKVDVMIVVGGKNSANTRKLAGICSER-T 229 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + +LI+ A ++++ W V VG+TAGAS PD +++ V ++ + E + E+ Sbjct: 230 QTYLIETADELEDNWFTGVVTVGLTAGASTPDWIIEEVYRKMSTMENKETHEMMNMED 287 >UniRef50_B6FZU7 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FZU7_9CLOT Length = 280 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 92/286 (32%), Positives = 160/286 (55%), Gaps = 7/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL-AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I ++ GFC GV RA+ + L + IY ++HN+ V+ ERG + + Sbjct: 1 MNIKISEKAGFCFGVKRAMGLAWRELCEEHDKQIYALGPLIHNKQAVEKYEERGLVTADD 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I E+P +I +HGVS+++ + A ++L V D TCP V K+H V +G++ ILI Sbjct: 61 IEEIPSDVKMIIRSHGVSKSIYDRADEKELEVVDTTCPFVKKIHDIVKENYDKGKKIILI 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G +N ++++ D+ +L + E + QTT++++ +++D Sbjct: 121 GDKNHPEVIGINGWCNN---SAIIIKTIDEAKELELDPEVDYCSVAQTTMNLEVYGNMVD 177 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L+++ KI + IC +T RQEA R LA + + ++V+G K+SSN+ +L + + + Sbjct: 178 ILKQKSDKIDF--NNTICSSTKARQEAARELASEMDCMVVIGGKHSSNTQKLVGICKEVC 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 F I+ D+ E +K+ + VG+TAGAS PD ++ +++ L+ L Sbjct: 236 -PTFAIETRDDLDVEEIKKYENVGITAGASTPDWIIDDIIEYLKSL 280 >UniRef50_Q1NXJ4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=delta proteobacterium MLMS-1 RepID=Q1NXJ4_9DELT Length = 361 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 89/285 (31%), Positives = 148/285 (51%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA GFC GV RA+ + PI ++HN V+ L ++G +E++ Sbjct: 85 MKVILAKHAGFCMGVRRAVETTLELVEKSRGPIATFGPLIHNPQVLTMLGQKGVEVLEEV 144 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G ++ AHGV A + + V DATCP V KV + + R+G ++++G Sbjct: 145 PEQSQG-TVVIRAHGVPPARKQSLEESGAVVEDATCPRVVKVQAIIDKYRRQGYTTVIVG 203 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EVEG +G ++ S +++ L +K ++QTT + + Sbjct: 204 DRDHAEVEGLVGHAG---EVGLVISSMEELDGLELKP--PYIVVSQTTQDEEMFQLITAG 258 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + RFP G + IC +T RQ+ VR + Q + ++VVG +NS+N+ RLAE+A+ + Sbjct: 259 VLSRFPG--GKVFNTICDSTHKRQDEVREMCRQVDALVVVGGRNSANTKRLAEIARGLAC 316 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 FL++ ++Q E ++ + VGVTAGAS P ++ VV L+ L Sbjct: 317 PVFLVETEAELQFEQMRRYQSVGVTAGASTPVWSIRQVVDALEAL 361 >UniRef50_Q72G65 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Deinococci RepID=ISPH_THET2 Length = 340 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 142/324 (43%), Positives = 195/324 (60%), Gaps = 18/324 (5%) Query: 2 QILLANPRGFCAGVDRAISIVE---NALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 ++ LA PRGFCAGV AI VE AL G + V HE+VHNR VV+ L+ +G F+E Sbjct: 9 RVYLARPRGFCAGVVMAIEAVERWAEALKEKGELV-VYHEIVHNRVVVERLQAKGVHFVE 67 Query: 59 QISEVPD-------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 ++EV ++FSAHG AVR +A LTV DATCPLVTKVH E R ++ Sbjct: 68 DLAEVERLRRERRLADTVVFSAHGHPPAVRRQAAEMGLTVLDATCPLVTKVHTEAKRYAK 127 Query: 112 RGEESILIGH-AGHPEVEGTMGQYSNP----EGGMYLVESP--DDVWKLTVKNEEKLSFM 164 G +LIG A H E++GT G+ ++ + P D + V + E++ + Sbjct: 128 EGYWILLIGDSADHQEIKGTYGEAPERTILVAVHTHVGKDPRLADPRTVEVPDPERVVVL 187 Query: 165 TQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKN 224 TQTTLSVDDT I L+KRFPK+V P + D+CYAT NRQEAV+ +A + E LV+ S + Sbjct: 188 TQTTLSVDDTLATIAILKKRFPKLVVPSRKDLCYATQNRQEAVKRIAPKVEAFLVLTSPH 247 Query: 225 SSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 SSN RL ELAQ + RA+ ++ ++++ EW++ V+ +G+T+ AS P+ LVQ VVARL+ Sbjct: 248 SSNGMRLLELAQSLVGRAYRLERPEELRPEWLEGVESLGITSAASTPEDLVQGVVARLKA 307 Query: 285 LGGGEAIPLEGREENIVFEVPKEL 308 G + EG E I F PK L Sbjct: 308 QNPGLEVVEEGAWETIAFREPKPL 331 >UniRef50_B1I3Y7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Clostridiales RepID=B1I3Y7_DESAP Length = 677 Score = 346 bits (888), Expect = 7e-94, Method: Composition-based stats. Identities = 92/285 (32%), Positives = 141/285 (49%), Gaps = 8/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ LA GFC GV RAI + + PIY ++HN VV L E+G +E+I Sbjct: 1 MEVRLATKAGFCFGVHRAIDLALKTVRETAPPIYSLGPLIHNPQVVAYLAEQGIEVVEEI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 VP G LI +HGV + + + TV DATCP V + + G + I++G Sbjct: 61 ERVPRG-TLIIRSHGVEPKLLEKTRELGFTVVDATCPFVKRAQRLACDLNDSGHQVIVVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G +G G +VE + L ++ + QTT + V++ Sbjct: 120 DRKHPEVRGIVGW---TNGQAVVVEDRVEASALPFYP--RVGVVAQTTQPHANLEAVVEE 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R ++ D IC A RQ A LA Q +V++VVG +S+N+ +L L + G Sbjct: 175 LKSRMGEV--LVCDTICNAVVERQNAALTLARQVDVMVVVGGIDSANTRKLTGLCRLSGT 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ +Q EW + G+TAGAS PD +++ V R+++L Sbjct: 233 PTYHIETGDQLQSEWFRGCTVAGLTAGASTPDWIIEEVKRRMEEL 277 >UniRef50_Q8F3I3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Leptospira RepID=ISPH_LEPIN Length = 330 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 138/313 (44%), Positives = 200/313 (63%), Gaps = 12/313 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I LANPRGFCAGV AIS VE A IYVR E+VHNR VV+ +++ G FI + Sbjct: 22 KIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDLD 81 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 E P+GA +IFSAHGVS +V AK R + + DATCPLVT+VH + + + + I IGH Sbjct: 82 EAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARK-IKDTHQIIYIGH 140 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVDDTSDVID 179 GH E GTMG+ M+LVES +D+ L + + L+++ QTTLSV DT ++ID Sbjct: 141 EGHDEAIGTMGEAE-----MFLVESLEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIID 195 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K FP + P KDDICYATT RQEAV + ++ + +LV+G+ NSSNS RL +LAQ+ Sbjct: 196 QISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADNSSNSLRLLQLAQKSK 255 Query: 240 KRAFLIDDAKDIQEEWVKE--VKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG-- 295 +F + A D+ +E+++ +K +G+TAGAS P +LV ++++L+ + L Sbjct: 256 PHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGS 315 Query: 296 REENIVFEVPKEL 308 R++++ F++P L Sbjct: 316 RDDSMNFKLPGVL 328 >UniRef50_C9KIS2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KIS2_9FIRM Length = 275 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 95/284 (33%), Positives = 147/284 (51%), Gaps = 10/284 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++LA+ GFC GV RAI I + G ++HN +VD LR G ++++ Sbjct: 1 MEVILADYLGFCYGVKRAIKIARENASADGTAC-TLGPIIHNPQMVDRLRREGVGSVDRL 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ G +I +HGV AV +EAK+R L V DATCP V K + G ++IG Sbjct: 60 EEMEKG-TVIIRSHGVGPAVYDEAKARGLEVVDATCPHVKKAQLSAKELVDEGYSVVIIG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ G ++E+ D+ + KL + QTT S ++ Sbjct: 119 EKEHPEVKSIFEW---SSGKAQIIETEDEAEAVE--PCGKLGIVCQTTFSGARFRQIVMR 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L ++ I IC AT RQ A LA + +++LV+G KNS+N+ RLA+L Sbjct: 174 LLEKSRDI--RILRTICTATDQRQAAAIDLASKVDLMLVIGGKNSANTTRLAQLCSEKCL 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 + I+ A ++Q+EW ++K +G+TAGAS PD +++ V + Q Sbjct: 232 -TYHIETAAELQDEWFDKIKKIGITAGASTPDWIIKEVYKKCQN 274 >UniRef50_A0LJ95 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Deltaproteobacteria RepID=A0LJ95_SYNFM Length = 580 Score = 342 bits (879), Expect = 7e-93, Method: Composition-based stats. Identities = 91/314 (28%), Positives = 155/314 (49%), Gaps = 17/314 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAI--YGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M++L+A GFC GV A+ + A+ G I ++HNR V+ L +G + Sbjct: 1 MKVLVAKTAGFCKGVRDALEVTLGAIKNQQDGENICTFGPLIHNRQVLAMLEAKGIREVN 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +I D ++ AHG+ R T+ DATC V KVH + R +RRG +++ Sbjct: 61 EIEGCAD-RKVVIRAHGIPPETRQTLHRLGATLLDATCKRVAKVHAAIKRHARRGYYTVI 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 +G A H EV G MG EG ++ + + +L + E + + QTT + + ++ Sbjct: 120 VGDADHAEVIGLMGY---TEGRGVVINRVEQLNELPAEW-ENVLLVAQTTQNEEVFQEIQ 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + K++PK G K+ IC +T RQ VR + E +++VG +S N+ RLA++A+ Sbjct: 176 EEFLKKYPK--GKVKNTICDSTHERQTEVREMCSLVEAMVIVGGFHSGNTLRLAQVAREC 233 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREE 298 + ++ ++ + + + VGV+AGAS P+ L++NVV L+ + + P Sbjct: 234 EIPTYHVETEAELNPQELAKYSRVGVSAGASTPNWLIRNVVRFLESIRPEQPEP------ 287 Query: 299 NIVFEVPKELRVDI 312 F V K L + Sbjct: 288 --RFSVKKTLELLA 299 >UniRef50_C1CUR9 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Deinococcus deserti VCD115 RepID=C1CUR9_DEIDV Length = 334 Score = 342 bits (878), Expect = 9e-93, Method: Composition-based stats. Identities = 133/320 (41%), Positives = 183/320 (57%), Gaps = 13/320 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLR-ERGAIFIEQI 60 +I LA PRGFCAGV AI VE A P+ V H +VHN VV+ LR G F+E + Sbjct: 4 RIHLAKPRGFCAGVVMAIQAVEKAARTEEKPVTVYHSIVHNHTVVERLRAGGGVHFVEDL 63 Query: 61 SEVP----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + +G +IFSAHG+S VR A+ L DATCPLVTKVH E + +R G Sbjct: 64 DAIEALPENGETVIFSAHGISPVVRERARQLGLATIDATCPLVTKVHTEAKKYAREGYTI 123 Query: 117 ILIGH-AGHPEVEGTMGQYSNPEGGMYLV-------ESPDDVWKLTVKNEEKLSFMTQTT 168 +LIG A H EV GT G+ + + ++ +D + V + ++ +TQTT Sbjct: 124 LLIGDSARHQEVIGTRGEAPDHTILVGVLGQAHNEDSGLNDPHTVEVPDPSRVVVLTQTT 183 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 LSVDDT +D LR RFP +V P +D+CYAT NRQ+AV+A+A ++ LV+ S +SSN Sbjct: 184 LSVDDTRRTVDVLRSRFPALVVPPSEDLCYATKNRQDAVKAIAPVVDMFLVLTSTHSSNG 243 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 RL ELA+ + RA ++ D+Q + V+ VG+T+ AS PD LVQ VV + L Sbjct: 244 MRLLELARSLCGRAERLETVADLQMLDLSGVRSVGITSAASTPDDLVQAVVEHFRSLNPL 303 Query: 289 EAIPLEGREENIVFEVPKEL 308 + EG ENI F P+++ Sbjct: 304 LQVTEEGEWENIEFREPRKI 323 >UniRef50_Q2RIU7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RIU7_MOOTA Length = 736 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 95/299 (31%), Positives = 143/299 (47%), Gaps = 16/299 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A+ GFC GV RA+ A P+ ++HNR VVD L G + + Sbjct: 1 MEVIVADYAGFCFGVKRAVEKAREA----PKPVASLGMLIHNRQVVDQLAREGVRPVASL 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G ILI +HG + A+ + L + DATCP V + + + G + I++G Sbjct: 57 DEVNCGRILI-RSHGTTPETLVRARDKGLEIIDATCPYVKRAQHLAQKMAAEGYQVIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPEV+G +G G +V L + + QTT +V A Sbjct: 116 DAAHPEVQGMLGWAG---PGAVVVPDKKAAAALPFHPRR--AVLAQTTQPESRLEEVAAA 170 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR +V + +C AT RQEA LA Q +V++VVG K S+N+ LAEL + G Sbjct: 171 LRSNTDTLV--VHNTVCQATHQRQEAAVRLARQVDVMVVVGGKESANTRHLAELCRATGT 228 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 + ++ A ++ +W + VGVT GAS P +++ VV L GE + EE Sbjct: 229 PTYHVERAGELCRQWFINTRRVGVTGGASTPAWIIEEVVGMLT----GEEKIMVPEEEK 283 >UniRef50_B5YH70 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YH70_THEYD Length = 289 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 84/289 (29%), Positives = 152/289 (52%), Gaps = 10/289 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I+LA GFC GV RAI I + + ++ ++HN VV+ L++ G +++IS Sbjct: 4 NIVLAEGAGFCFGVKRAIDIAFDVAQKHKDGVFTLGPIIHNPQVVERLKDLGVYPVDEIS 63 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 + LI AHG+ + NE K D + DATCP V K + + G + ++IG Sbjct: 64 Q-KTIKTLIIRAHGIPKEKFNELKQLDCEIIDATCPFVKKAQNLAEKLASEGYQVLIIGD 122 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPD----DVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 HPEV+G ++ D + K+ + +K+ + QTT + ++ Sbjct: 123 REHPEVKGIFSYAG---EKAIVINHADNELKESKKIPI-LNKKIGIIQQTTQPMSKVKEI 178 Query: 178 IDALRKRFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 ++ + + + +C T+ R EA +A++ +V++VVG KNS+N+ +LA L + Sbjct: 179 MNKIINSLNEFEEIRIFNTLCNFTSRRLEATEKVAKEVDVMIVVGGKNSANTTQLANLCR 238 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++G + + I+DA++I ++WV K +GVTAGAS P ++ V+ ++++ Sbjct: 239 KIGVKTYHIEDAQEIDKKWVNSAKKIGVTAGASTPQWIIDEVIDKIKKF 287 >UniRef50_B2A4N7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A4N7_NATTJ Length = 705 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 92/313 (29%), Positives = 161/313 (51%), Gaps = 19/313 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP---IYVRHEVVHNRYVVDSLRERGAIFI 57 M+IL+A GFC+GV+RA+ A+ + ++ +VHN+ V+ +L E+G I Sbjct: 1 MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGII 60 Query: 58 EQISEVPD--------GAILIFSAHGVSQAVRNEAKSR-DLTVFDATCPLVTKVHMEVAR 108 E ++++ ++ +HGV + + V DATCP V KV + ++ Sbjct: 61 ENLTQLQSKKCLSEETNNYVVIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASK 120 Query: 109 ASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTT 168 + G + ++G HPEV+G N ++E P+ V + + N K + + QTT Sbjct: 121 LYQDGYQIFIVGDPNHPEVKGIKEWTDNN---AIVIEKPEQVNDIEISN--KTAVVAQTT 175 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNS 228 L + +++++ + R P + + IC AT RQ A + LA Q +V++VVG NSSN+ Sbjct: 176 LREEKFNEIVEKILDRNPNTI--VHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNT 233 Query: 229 NRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 +L ELA + G + I+ AK+++ +W K +GVTAGAS PD ++ VV ++++ Sbjct: 234 KKLKELAVKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQ 293 Query: 289 EAIPLEGREENIV 301 +E+ Sbjct: 294 NENLNTNSDESTQ 306 >UniRef50_D1NAP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1NAP1_9BACT Length = 309 Score = 338 bits (868), Expect = 1e-91, Method: Composition-based stats. Identities = 138/305 (45%), Positives = 200/305 (65%), Gaps = 6/305 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I +A P G CAGV RA+ VE L AP+YV HE+VHN ++V+ L+ERG IF E ++ Sbjct: 6 KIFIARPHGMCAGVRRALDTVEAVLKSAPAPVYVLHEIVHNNFIVNRLKERGVIFAETLA 65 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVP+GA+L+FSAHGVS AV EA+ R L DATCPLV + +++ R GE ILIGH Sbjct: 66 EVPEGAVLLFSAHGVSAAVEEEARRRSLRTVDATCPLVKSLQSAASKSFRPGEVLILIGH 125 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT-VKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEVEG +G+ G ++++ +V L + + ++QTTL+++ +V+ A Sbjct: 126 RGHPEVEGVLGRVP-AGGTVHVISGAAEVPGLPELPAGTPVRALSQTTLNLEAVDEVLAA 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 LR R+P++ +CYATTNRQ+AVR LA + +L++GS SSNSNRL E+A++ G Sbjct: 185 LRNRWPQLESGPG--VCYATTNRQKAVRQLAARCRTILIIGSPRSSNSNRLREIAEQAGA 242 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 RAFLID +++ + + +GV+AGASAP+ LV+ V RL++LG G + P+E E + Sbjct: 243 RAFLIDGPQELPP--LDPSQDIGVSAGASAPEELVEATVERLRRLGYGASEPVEAAVETV 300 Query: 301 VFEVP 305 F +P Sbjct: 301 AFRLP 305 >UniRef50_A9KLR6 Hydroxymethylbutenyl pyrophosphate reductase n=58 Tax=Bacteria RepID=A9KLR6_CLOPH Length = 643 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 88/300 (29%), Positives = 160/300 (53%), Gaps = 14/300 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA GFC GV RA+ V ++ G +Y ++HN VV L ++G I + Sbjct: 1 MKITLAKTAGFCFGVKRAVDKVYEEISN-GKEVYTYGPIIHNDEVVKDLEDKGVKVIHSL 59 Query: 61 SEVP--DGAILIFSAHGVSQAVRNEAKS------RDLTVFDATCPLVTKVHMEVARASRR 112 E+ D ++ +HGV ++V ++ K ++ + DATCP V K+H V S Sbjct: 60 DELKKLDRGTIVIRSHGVPKSVLDQIKEIEETEGKNFDLVDATCPYVLKIHRIVKEQSEL 119 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G + I+IG HPEV G +G NP + +V + ++ K+ + +E+K+ + QTT + Sbjct: 120 GRQLIVIGDKEHPEVSGIIGWCKNP---VIVVGNAEEAEKIQLSSEQKVCIVAQTTFNYK 176 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 + ++++ + K+ I + IC AT RQ L++ +E ++V+G K+SSN+ +L Sbjct: 177 NFQELVEIISKKGYDI--LVLNTICNATEERQTEAAMLSKTSEAMIVIGGKHSSNTRKLY 234 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 E++++ + I D+ +K + VG+TAGAS P+ +++ V R+ ++ + + Sbjct: 235 EISKKECANTYYIQKLIDLDLNQLKSFRSVGITAGASTPNNIIKEVHTRMAEMSFEQLLE 294 >UniRef50_C0GLE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GLE4_9DELT Length = 297 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 81/285 (28%), Positives = 142/285 (49%), Gaps = 5/285 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 Q+LLA GFC GV A+ ++ AL I+ ++HN V++ +G I+ Sbjct: 4 QVLLAESAGFCMGVSLALGKLDKALENQTSQRIFTYGPIIHNPQVLEYYHGKGVKIIDNW 63 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E G +++ AHGV V + + +++ + DATCP V K + + + S + ++ G Sbjct: 64 DEPRPGDMVLIRAHGVPLQVEEKLREKNIDILDATCPKVKKAQLLIYKNSAVSDRLLIYG 123 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G + + +L E+ + K+ + +++ ++QTT + + Sbjct: 124 ELDHPEVKGLLSYA---QCEAFLFENMQEFKKIALAPKDRYCLVSQTTQDRQEFLSIASE 180 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ D IC AT +RQ +A Q E + VVG +NS N+ RL ++A++ Sbjct: 181 LK-HSQGNEIITLDTICDATKDRQNETIKIAGQVECMFVVGGRNSGNTRRLYQVARKYCP 239 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R I+ ++I E VK VG+TAGAS P+ +Q++ L ++ Sbjct: 240 RCLHIETKEEIDPEMVKGCSKVGLTAGASTPNSTIQSIYQYLHRI 284 >UniRef50_C1SLB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; SSU ribosomal protein S1P n=2 Tax=Bacteria RepID=C1SLB2_9BACT Length = 848 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 78/284 (27%), Positives = 144/284 (50%), Gaps = 8/284 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 ++I +A+ GFC GV+RA+S+VE+ + +Y ++HN +V E G Sbjct: 6 VEIFIADHAGFCFGVERAVSLVEDTSKQFTG-VYTLGPIIHNPQIVSKFAENGIGVCYNP 64 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV + ++ +HGV++ SR + V DATCP V K + G ++ G Sbjct: 65 EEVNEDNTVVVRSHGVTKETYATLASRKVNVVDATCPFVKKAQNSAKKLGNEGAVVVVYG 124 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ + + +V + L +E + + QTT + + + + Sbjct: 125 EKNHPEVKSIVSF---IDSRYVIVSDVGEASVLP--DENCYALVAQTTQNSESFDKIAEI 179 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + K++ K+ IC AT+ RQ + LA++ ++++V+G +NS N+ RL E+ + + Sbjct: 180 LKTKCDKLI--IKNTICNATSLRQASAIDLAKKVDIMVVIGGRNSGNTTRLYEICKNICA 237 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 I+ +++++E + VG+TAGAS P LV+ V+ L++ Sbjct: 238 NTHHIETKEELKKEIFDGCRKVGITAGASTPGYLVEEVIEFLKE 281 >UniRef50_C1XXH1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Meiothermus RepID=C1XXH1_9DEIN Length = 343 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 131/326 (40%), Positives = 185/326 (56%), Gaps = 21/326 (6%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAP--IYVRHEVVHNRYVVDSLRERGAIFIEQ 59 ++ LA PRGFCAGV AI VE A + V H +VHN VV L ++G F+E Sbjct: 4 RVYLAKPRGFCAGVVMAIQAVEKAAQELKEEGELVVYHAIVHNDVVVKRLEQQGVHFVED 63 Query: 60 ISEVPD------------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVA 107 ++EV ++FSAHG+ +R EA R L+ DATCPLVTKVH E Sbjct: 64 LAEVERLRKERRKAGAKLADTVVFSAHGIPPRLRTEAAQRGLSQIDATCPLVTKVHSEAK 123 Query: 108 RASRRGEESILIGH-AGHPEVEGTMGQYSNP----EGGMYLVESP--DDVWKLTVKNEEK 160 R ++ G +LIG A H E++GT G+ ++ P D ++ V + EK Sbjct: 124 RYAKEGYWILLIGDSADHQEIKGTRGEAPERTILVSVHTHVGRDPRLADPRRVEVPDPEK 183 Query: 161 LSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVV 220 + +TQTTLSVDDT I+ L+ RFPK+V P +DD+C+AT NRQ+AV+ +A ++ LV+ Sbjct: 184 VVVLTQTTLSVDDTLATIEILKARFPKLVVPSRDDLCFATKNRQDAVKQIAPHVDLFLVL 243 Query: 221 GSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVA 280 S SSN RL ELA+++ RA I+ D++ EW++ VK VG+T+ AS PD LVQ VV Sbjct: 244 TSTASSNGMRLLELAKQLVGRAERINTVADLKPEWLEGVKSVGITSAASTPDDLVQEVVG 303 Query: 281 RLQQLGGGEAIPLEGREENIVFEVPK 306 + + +G E+I F P+ Sbjct: 304 YFRSHNPALEVIEQGEWEDIEFREPR 329 >UniRef50_D1B5G9 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5G9_THEAS Length = 280 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 92/285 (32%), Positives = 150/285 (52%), Gaps = 5/285 (1%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L+A+P G C GV RAI +E L G +Y +HN V+ L+ +G + +++I Sbjct: 1 MKVLVASPTGLCFGVRRAIEALEATLEERG-RVYSLGSPIHNPQEVERLKAKGLVVVDEI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VP G L AHGVS V EA R V D TCP V K S G +++G Sbjct: 60 DQVPPGVTLFIRAHGVSPQVFREALRRCGEVIDGTCPFVRKAQERAMVLSDEGYPVLIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G + + ++V L +K+ ++QTT ++ DV+ A Sbjct: 120 DGEHPEVKGILGFVNGFAAVVPHRGRLEEV--LDGHRFQKVGVLSQTTQKLEVFFDVVKA 177 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L P++ + IC AT RQ AV LA + ++V+G +NS+N+ +L ++A G Sbjct: 178 LVGIVPEV--RVYNTICSATLERQRAVCELASSVQGIVVMGGRNSANTRKLYQIALESGA 235 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +A I+ ++ W+ + +G+ AG S PD L++ ++ RL++L Sbjct: 236 QAVWIEHPDELDYGWLADKGSIGLAAGGSTPDWLIRELIERLEKL 280 >UniRef50_C2D7I4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D7I4_9ACTN Length = 282 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 91/289 (31%), Positives = 140/289 (48%), Gaps = 9/289 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I +A G C GV+RA+ +VE I+ ++HN VV L +G I Sbjct: 1 MHIRIATEAGACYGVNRALDMVEALSHKIHGRIHTLGPLIHNPQVVSKLAAKGVEVIHNA 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G ++ HGV+ +A V DATCP V + H ++ G + ++ G Sbjct: 61 DEV-SGKAILLRTHGVTPEEEKKAYQSHDIVVDATCPFVIRAHRAAETLTKEGYQVLVFG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 GH EVEGT+G VE+P+D+ L++K ++ + QTT S +++ A Sbjct: 120 EKGHAEVEGTLGHAPG----AVCVETPEDIEALSIK--RRVGIVVQTTQSRRRLKEIVAA 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L + +I D IC AT+ RQ A LA+ + ++V+G K S+N+ RLAE+ + Sbjct: 174 LVGKAEEI--RLFDTICEATSLRQNAATDLAKSVDCMIVIGGKISANTTRLAEICRTYCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 + I+ A+++ W VG+TAGAS P + V RL L Sbjct: 232 HVYHIETAEELDPAWFSPTSEVGITAGASTPQYQIDEVYKRLMSLYPAS 280 >UniRef50_C0GDV0 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GDV0_9FIRM Length = 678 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 99/314 (31%), Positives = 168/314 (53%), Gaps = 12/314 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A GFC GV +A+ +A +Y + HN ++D LRE G IF++ + Sbjct: 1 MKVIVAEHAGFCGGVKKAVKQALDASRQ--GRVYALGPLAHNDSLLDKLREEGVIFVDDL 58 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +EVP GA ++ +HG V +A+ R L + DATC V K+ VAR G++ I++G Sbjct: 59 AEVPHGATVVIRSHGERPEVFRQAEERGLQIVDATCTFVGKLQTLVARLIEEGKQVIVLG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE++G +G + + S ++ L E+ ++ + QTT +++ + Sbjct: 119 DPTHPEIKGVLGWGRDQPIVLTADGSISELEGLN--REKPVALVAQTTQRQSILAEIGEK 176 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ P V + IC AT RQEA R LA ++++VVG KNS+N+ +LA++ + G Sbjct: 177 LKAIVP--VVEIYNTICQATALRQEAARNLAYDVDLMVVVGGKNSANTRKLADVCRSTGV 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 R + +A ++ E +KEV+ VGVTAGAS PD ++ V+ +++ E + E + Sbjct: 235 RTIAVSEAHELDAEQLKEVRTVGVTAGASTPDWTIKEVIGKMENEKNTELQEEQTATEEV 294 Query: 301 VFEVPKELRVDIRE 314 L +I+E Sbjct: 295 ------SLDQEIKE 302 >UniRef50_B6GBX2 Putative uncharacterized protein n=2 Tax=Collinsella RepID=B6GBX2_9ACTN Length = 283 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 98/283 (34%), Positives = 151/283 (53%), Gaps = 8/283 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I +A G C GV+RA+++ A P+ ++HN VV L G +++ E Sbjct: 5 IEVARHAGVCYGVERALTLAAEAARESRGPVRTLGPLIHNPLVVSELEHAGVTVADRVEE 64 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 V G +I AHGV V + A+ LTV DATCP V KVHM + R G + I++G + Sbjct: 65 VDAG-TVIIRAHGVVPQVVDRAERLGLTVLDATCPYVKKVHMAAEKLVREGYQLIVVGES 123 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 GHPEVEG MG + +V +P D+ + + K+ + QTT +V S ++ AL Sbjct: 124 GHPEVEGIMGHA---DERARVVSTPADLDAIELS--RKVGVVVQTTQTVGALSSIVSALL 178 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 R ++ + IC AT RQ++ LA + +V++VVG KNS N+ RLA++ Q Sbjct: 179 SRTSEL--RVINTICAATQERQDSAAELAARVDVMIVVGGKNSGNTRRLAQICQMGCAHT 236 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 I+D+ +++ W V+ +GVTAGAS P + V +++ L Sbjct: 237 HHIEDSSELEASWFTGVEHIGVTAGASTPAAHIDRAVEKIRAL 279 >UniRef50_A7HCQ8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Anaeromyxobacter RepID=ISPH_ANADF Length = 283 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 84/286 (29%), Positives = 138/286 (48%), Gaps = 8/286 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ +A GFC GV R + V P+ ++HN V RE+G ++ + Sbjct: 1 MEVKIAKTAGFCWGVRRTVDKVMEVADHASGPVVTLGPIIHNPQAVARFREKGVGTVDAV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV DG ++ HG + + A+ R L V D TCP V R S G +++G Sbjct: 61 GEVGDGTTVVVRTHGAVKEELDRAEGRGLEVVDGTCPYVKYPQAIAQRLSAEGYHVVIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A H E++G + P +V+ + ++ +K++ + QTT D V+ A Sbjct: 121 DANHAEIKGVISYSEGP---CTVVKPGGPIPEIP---AKKVAVIAQTTCIGADFEAVVGA 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R + IC T RQ R+LA + + V+VVG KNS+N+ LAE+ + + Sbjct: 175 LALR--HKEVRAVNTICNDTEERQADARSLAREVDAVVVVGGKNSANTRHLAEICREIQP 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 R + ++ +++ EW + VG++AGAS PD +V+ V L+ L Sbjct: 233 RTWHVETEAELRPEWFTGCQVVGLSAGASTPDWVVEGVAGWLRGLH 278 >UniRef50_D2RKJ8 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Veillonellaceae RepID=D2RKJ8_ACIFE Length = 680 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 93/285 (32%), Positives = 151/285 (52%), Gaps = 6/285 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A+P GFC GV RAI++ E Y I E+VHN VV+ L+++G E++ Sbjct: 1 MKIYVADPCGFCYGVKRAINVAEVQAKGYNDSIATLGELVHNPRVVEKLKQQGVECKEKL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G +IF +HGV A+ EA+ R+L V DATCP V K A + G I++G Sbjct: 61 AQFAAGDTVIFRSHGVGPALYEEARQRELNVIDATCPHVRKAQKTAAELAGEGRFVIIVG 120 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+ ++E+ DD+ L K+ K ++QTT + + ++ Sbjct: 121 EKRHPEVQSIKAWAG---SDSVVIETSDDLGSLPEKD--KFGVVSQTTFEAEKFNLLLRM 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +++ P IC AT RQ A R LA + + V G KNS+N+ L ELA+ + Sbjct: 176 AQEKRPG-DYKVVRTICTATAERQAAARQLAGKTDAFFVFGGKNSANTRHLWELAREINP 234 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++L+ DA +I + + +G+TAGAS P +++ + ++ + Sbjct: 235 RSYLLQDASEITGPMLAGAQKIGITAGASTPQEIIEEAIGTMETM 279 >UniRef50_D1CF50 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=D1CF50_THET1 Length = 293 Score = 330 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 93/295 (31%), Positives = 139/295 (47%), Gaps = 8/295 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQ+ LA GFC GV + + + + + + +VHN VV L+ RG + Sbjct: 1 MQVKLARELGFCFGVKKTLKL-FDEMGSDSRGVKTLGTLVHNPQVVSELKARGVGVAYSV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G L +AHG EA+ + L + D TCPLVTKV + G + ++ G Sbjct: 60 DEVDSG-TLTITAHGAGPDAYAEAQRKGLRLLDTTCPLVTKVQKIAESLHKDGYQVVVYG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMY----LVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 H EV G +G N LV + + +KL+ ++QTT + Sbjct: 119 DPNHQEVRGIVGWTENTALVSTDAKELVPRLKALTSSKKRVPKKLAVVSQTTQPAERFKS 178 Query: 177 VIDALRKRFPKI--VGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 I L P + IC T +RQ AV LA + +V++VVG ++S+N+ LAEL Sbjct: 179 FIAELVSLLPDDFNEFHVHNTICQPTLDRQSAVVELANEVDVMVVVGGRDSANTKHLAEL 238 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 A G + I+ ++I W K K VGVTAGAS PD +++ VV ++ + E Sbjct: 239 ASEEGVPTYHIEWPEEIDPNWFKGAKVVGVTAGASTPDAVIEKVVKTIEAIEPEE 293 >UniRef50_Q0STT3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=36 Tax=Clostridium RepID=ISPH_CLOPS Length = 282 Score = 328 bits (842), Expect = 1e-88, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 161/288 (55%), Gaps = 13/288 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE--Q 59 ++LA GFC GV RA+ +G IY ++HN VV+ L + IE Sbjct: 4 NVILAKNAGFCFGVKRAVDEAIKYQKEFGKKIYTLGPLIHNNDVVNYLEDNDIFAIELSD 63 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + G +++ +HGV ++V + + L V +ATCP VT + ++V + +G + I++ Sbjct: 64 TNSLNKGDVVLIRSHGVKESVIKDLTDKGLIVKNATCPYVTNIQLKVKKCYEQGYKIIIV 123 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV G G ++ + ++ + K+ ++QTT + + V++ Sbjct: 124 GDENHPEVIGINGWCND---SAIITNGKTELENIPA----KVCVVSQTTEKKETWNKVLN 176 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K +IV + IC AT RQ++V+ L+++A++V V+G KNSSN+ +L E+ ++ Sbjct: 177 EIVKESKEIV--AFNTICSATDVRQKSVQELSKEADLVFVIGGKNSSNTTKLYEICKKEC 234 Query: 240 KRAFLIDDAKDIQEEWVKE--VKCVGVTAGASAPDILVQNVVARLQQL 285 +++ I++ K++ E +++ VK +G+TAGAS PD ++ V++++++L Sbjct: 235 PKSYHIENVKELDESLLEDESVKTIGITAGASTPDWIINEVISKIKEL 282 >UniRef50_Q0AXA2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AXA2_SYNWW Length = 687 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 102/306 (33%), Positives = 157/306 (51%), Gaps = 15/306 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M +LLA GFCAGV +A+ I E A + +VHN VV+ R++G ++ + Sbjct: 1 MYVLLARNAGFCAGVRKAVKIAEEAAEEPDK-WFSLGPLVHNDEVVNYFRQKGIEPVDML 59 Query: 61 SEVPDG-AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + A +I +HG S V +A+ L V DATC LV K+H V R + ++ Sbjct: 60 ERIGEQPAGIIIRSHGTSPEVIKQAQELGLEVRDATCVLVKKIHEIVTRLRGEDYDIVVF 119 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G A HPEVEG +G +V S D+V L V K++ ++QTT + V Sbjct: 120 GDARHPEVEGILGWCGQ---RASVVASADEVGYLPVMP--KVALISQTTRDEKEFQKVAG 174 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 AL + ++ + IC AT +RQEA R L + +++LV+G SSN+ L++ Q G Sbjct: 175 ALSNKCREL--KVFNTICSATRSRQEAARELCRKVDLMLVIGDLKSSNTRTLSKECQNTG 232 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL------QQLGGGEAIPL 293 R F I A +I+ EW+ V +G+TAGAS PD +++ V+ R+ + L + Sbjct: 233 VRTFQIQKASEIKPEWLDGVSKIGITAGASTPDWIIKEVLDRMTLYEEEKMLDENQETNQ 292 Query: 294 EGREEN 299 E +E Sbjct: 293 ETSQET 298 >UniRef50_C7N521 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N521_SLAHD Length = 276 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 94/285 (32%), Positives = 145/285 (50%), Gaps = 9/285 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL A G C GV+RA+ +V A + ++HN VV L RG ++ Sbjct: 1 MEILRAKHAGVCYGVERALDMVSAASMDGDEDTFTLGPLIHNPQVVAKLESRGVRAVDGP 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +V G I+I HGV + + KSRDLTV DATCP V K A + ++IG Sbjct: 61 EQVDHG-IVILRTHGVEPHIAADLKSRDLTVIDATCPHVAKAQRSAANLADTCGTVLIIG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 A HPE+ +V DV ++ EE + + QTT S + V++ Sbjct: 120 RAEHPEIRSVREYAG---EKAIVV---ADVDEVPEHLEEPVGVIVQTTESKEKLQAVVNE 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L R + K+ IC+AT RQ+A ALA++ + ++V+G KNSSN+ L E+ + Sbjct: 174 LEAR--GVETQVKNTICFATRQRQDAAAALADEVDAMVVIGGKNSSNTTHLYEICRDHCD 231 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 R++ ++ +++ W VGVTAGAS PD +++V++ L+ L Sbjct: 232 RSYFVETKEELDPSWFSATDRVGVTAGASTPDYQIEDVISYLESL 276 >UniRef50_A3ERP9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Leptospirillum RepID=A3ERP9_9BACT Length = 302 Score = 327 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 102/300 (34%), Positives = 167/300 (55%), Gaps = 8/300 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I L G C GV RAI + P+++ HE+VHN +VV L ERG ++++ Sbjct: 1 MDIFLPEYAGVCVGVKRAIKMAHKTAEEATGPVFILHEIVHNTHVVKDLSERGVKSVDEV 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 EV G LI SAHGV+ V +A+SR+L V D TCPLV K+H V + + L+G Sbjct: 61 KEVDKG-TLIISAHGVAPEVIADARSRNLEVVDTTCPLVWKIHRIVKALAEKNYTIFLLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G + +++ +++ L + E ++ ++QTT S+ +++D Sbjct: 120 ERNHDEVMGVQGVAKD---HIHIFHKKEEIAHLPL-TEGPVALVSQTTQSIKYFDEILDL 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L +R+P++ + IC AT RQ + A+A +V++ VGS +S+NS RL E++ + + Sbjct: 176 LLERYPQLE--IHNTICDATEKRQTSALAIAGDMDVMITVGSMSSANSRRLQEVSAGLCR 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL-GGGEAIPLEGREEN 299 ++L+D A ++ + W K + VGVTAGAS P+ L++ V+ +L ++ P R E+ Sbjct: 234 ASYLVDSANEVSDTWFKGGERVGVTAGASTPEWLIEGVIEKLMEISRAKGFEPSVTRNES 293 >UniRef50_C9LMR5 Hydroxymethylbutenyl pyrophosphate reductase/ribosomal protein S1 n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMR5_9FIRM Length = 658 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 144/297 (48%), Gaps = 9/297 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I A GFC GV +A+ I ENA + ++HN VV L +G + Sbjct: 17 MKIYKARVMGFCYGVRKAMEIAENAAVSGQKTV-TLGPIIHNPQVVARLAGKGISPVMST 75 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ D +I +HG+ + N K + + DATCP V + + G++ +L+G Sbjct: 76 DEITD-ETVIIRSHGIGPSCYNNLKRKKSVLLDATCPFVKRNQEIAKGLAAEGKKIVLVG 134 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE+ Y+VE+ +DV L + +++ + QTT S+ +I A Sbjct: 135 EKKHPEMLSVAEWAGEAP---YIVETMEDVEALP--DLDEVHIVIQTTFSLSLADRLITA 189 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++++ + IC AT++RQ A LA +V++V+G +NS+N+ RL E+ Q G Sbjct: 190 IKRKAGSV--SVHKTICNATSDRQTAAGELARNVDVMIVIGGRNSANTGRLVEVCQAEGA 247 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 I+ A ++++EW VG+TAGAS PD +++ V ++ + + Sbjct: 248 VTHHIETAAELKKEWFHSQCKVGITAGASTPDWIIEEVFFIMEDMNEMLEQEEMNLD 304 >UniRef50_A0RQC4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=51 Tax=Epsilonproteobacteria RepID=ISPH_CAMFF Length = 279 Score = 326 bits (837), Expect = 6e-88, Method: Composition-based stats. Identities = 91/286 (31%), Positives = 159/286 (55%), Gaps = 13/286 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRER-GAIFIEQ 59 M+I LA GFC GV RAI I EN+ E++HN +D L+ ++ Sbjct: 1 MKIELAKSYGFCFGVKRAIKIAENSKNAS-----TIGELIHNSLEIDRLKNNFNVKTLKD 55 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 ISE+ + I HG+++ KSRD+ + DATCP VTK V + S G E + Sbjct: 56 ISELKNEKKAIIRTHGITKEGLANLKSRDVEIIDATCPFVTKPQQIVEKMSSEGYEIVFF 115 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G M S +Y++ ++ + + + K++ ++QTT ++ + ++ Sbjct: 116 GDINHPEVKGVMSYSSKN---VYVILDESELETVKLPS--KIAVVSQTTKKIEKFTKIVS 170 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L +R ++ + IC AT QEAVR L+ +A+V++++G KNSSN+ +L +++ + Sbjct: 171 YLMQRVKEV--RVFNTICNATLENQEAVRELSSRADVMVIIGGKNSSNTKQLYLISKNLC 228 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 ++LI+ +++ +W + K G++AGAS P+ ++QNV+ +L+ L Sbjct: 229 PDSYLIESENELELKWFQNKKLCGISAGASTPEWVIQNVINKLENL 274 >UniRef50_C0R0R2 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Brachyspira hyodysenteriae WA1 RepID=C0R0R2_BRAHW Length = 581 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 140/298 (46%), Gaps = 8/298 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + + GFC GV A+ + + + IY+ ++HN +D L G E Sbjct: 1 MNVDIGKFAGFCDGVKYAVENTFSQASKKNSDIYIDGHLIHNPQTLDMLENIGVKTYEDD 60 Query: 61 SE--VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 + V DG +I AHG+S R S + + TC V K+ V + S G I+ Sbjct: 61 EDMSVLDGKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKYSSLGYRVIV 120 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IG+ HPE+ G G + +Y+V +D+ KL + +K + QTTL + Sbjct: 121 IGNPVHPEIVGVCGYADD----VYVVYKDEDLNKLP-NDSKKALIVAQTTLQKSAFDKFV 175 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 ++ ++ K+ IC AT RQ V +A++ +VVLV+G SSN+ L +A + Sbjct: 176 AQIQDKYKDTEIIIKNTICAATEQRQNEVLEIAKRNDVVLVIGGSESSNTRNLYNIASSI 235 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 K AF ++ +D+++ + K +G+ AGAS PD L++++ ++ R Sbjct: 236 -KPAFYVEYKEDLEKIDLSNYKNIGIMAGASTPDWLIEDIAQTIKDKYATNFYRFISR 292 >UniRef50_C7MNA7 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C7MNA7_CRYCD Length = 284 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 91/291 (31%), Positives = 145/291 (49%), Gaps = 7/291 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A+ G C GV RA+++ + A G + ++HN VV L G + + Sbjct: 1 MEIIIASRAGACYGVQRALNLAQKAA-QSGGDVQTLGSLIHNPQVVAELAASGVEAVSKP 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 E+ + I +HGV+ VR + + DATCP V + + G I++G Sbjct: 60 EELTA-SRAIIRSHGVTPQVREGIEQAGADIIDATCPHVLRAQQAARDLALEGRLVIVVG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEVEG G + + +PDDV + + + + QTT + +ID Sbjct: 119 EESHPEVEGLRAWAEQAGGQVVVAATPDDV---PSQIDGSVGIVVQTTQRREKLDAIIDV 175 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ R I +D IC AT+ RQEA LA Q +V++V+G NSSN+ RL E+ + Sbjct: 176 LKSR--GIEAEIRDTICSATSTRQEAAAELASQVDVMVVIGGHNSSNTTRLFEICRARSP 233 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +AF I+ ++Q K + VGVTAGAS P+ +++V+ RL+ + Sbjct: 234 QAFHIESPDELQAIDFKGAQRVGVTAGASTPEDQIESVIERLRSFAESQEE 284 >UniRef50_C1TMG2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMG2_9BACT Length = 275 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 80/282 (28%), Positives = 136/282 (48%), Gaps = 8/282 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++++A P G C GV RAI +E AL G ++ +HN V L ++G + +E Sbjct: 1 MKVVVAEPTGLCFGVKRAIRTMEEALEEKG-RVFCIGSPIHNPQEVQRLVDKGLVVVEDD 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +P + AHG+S V + + + D TCP V K R SR G +++G Sbjct: 60 DRIPPDEPVFVRAHGISPDVHQRLQDKGARIIDGTCPFVRKAQEMAGRLSREGYYLVVLG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE++G +G P +V D+ + ++ + +QTT +++ Sbjct: 120 DENHPEIKGILGYVEGPY---LVVSGKKDLRAIDKIDKIGII--SQTTQQESTLKELVSE 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +I + IC AT RQEAVR LA + + ++++G NS+N+ +L +AQ G Sbjct: 175 AVGSAREI--KVSNTICRATVERQEAVRRLAYKVDGIVIIGGHNSANTGKLFRIAQESGT 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 A ++ A + W+ +G+ AGAS PD L++ + + Sbjct: 233 PALWVEQADQLDGRWLSGKGTIGIAAGASTPDWLIKQLQQAM 274 >UniRef50_D1PP74 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=8 Tax=Bacteria RepID=D1PP74_9FIRM Length = 639 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 90/304 (29%), Positives = 153/304 (50%), Gaps = 11/304 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+++ A GFC GVDRA+ + + L G + ++HN VV L +GA+ + + Sbjct: 1 MKVIRAKTAGFCFGVDRAVKLTYDLLGQ-GRRVATLGPLIHNPQVVQDLEAKGALTCDGV 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +VPDG +I +HGV Q V + +R L DATCP V K+H A A ++G ++ G Sbjct: 60 EDVPDGYEVIIRSHGVPQNVYEKISTRGLAYHDATCPFVAKIHKLAAEAGKKGALLLVAG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVDDTSDVI 178 A HPEV+G +G + P + + +++ L + +E + + QTT V+ Sbjct: 120 DANHPEVQGIVGHATGP---VRVFADLEELQNLLPELLQQESIHVVAQTTFRVESWESCK 176 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 L+K K D IC AT RQ+ L+++ + ++V+G +SSN+ +L ++A R Sbjct: 177 AFLKKECTKAE--IFDTICNATWARQQEAEDLSQKCDRMVVIGGHHSSNTQKLLQVAARH 234 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ--LGGGEAIPLEGR 296 A ++ A ++ W+ + VGVTAGAS P +++ V+ + + + Sbjct: 235 -TTAINVETADELDPAWLAGAETVGVTAGASTPSSIIEEVLNSMSEEIRDDMSFEEMLAA 293 Query: 297 EENI 300 E Sbjct: 294 SEAK 297 >UniRef50_Q3ZYL6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Dehalococcoides RepID=ISPH_DEHSC Length = 284 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 142/290 (48%), Gaps = 9/290 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++ A+ GFC GV RAI+I+E + G + +VHN+ V++ L G ++ I Sbjct: 1 MKVECASNIGFCFGVRRAINILEKTASERGG-VETLGALVHNQQVLNRLSGMGVRVVKNI 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ G + S+HGV AV E KS+ L + D TCP V + + R G +++ G Sbjct: 60 DDI-SGRTVAISSHGVGPAVLAELKSKGLEIVDTTCPFVKRAQVAAKRFHDAGFFTVIYG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +G + DD+ L + ++QTT + + Sbjct: 119 DVNHPEVKGILGWAGGNGLATLNPQGLDDIPDL----SRYIGVLSQTTQIPTGFTSFVKN 174 Query: 181 L--RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + D +C+ +RQ A LA + +++LV+G NS+N+ L +L + + Sbjct: 175 VIDQALVKDAEIRIADTLCHDIRDRQAAALELAGRVDLMLVIGGHNSANTRHLLDLCKTV 234 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 LI+ A ++Q +W+K V +G+T+GAS + + V + L +L G Sbjct: 235 S-NTHLIETASELQTDWLKGVSRIGITSGASTDETTISEVCSYLDRLSAG 283 >UniRef50_C7LQM8 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LQM8_DESBD Length = 286 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 83/291 (28%), Positives = 148/291 (50%), Gaps = 8/291 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALA---IYGAPIYVRHEVVHNRYVVDSLRERGAIFI 57 M++++A GFC GVD A+ ++NA++ IY ++HN V+ + G + Sbjct: 1 MELIIAETAGFCMGVDMALHKLDNAVSIPPQDAQHIYTLGPIIHNPQVLARYKGLGVLQT 60 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + + G +++ AHG+ + ++ + +++TV DATCP V K + + R + + + + Sbjct: 61 DGTKPLQTGDVVVIRAHGIPRHIQTSLEGQNITVVDATCPKVKKAQILIQRQADQNKHLL 120 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 L G HPEV+G + + ES +++ V + QTT + + Sbjct: 121 LFGERDHPEVQGLVSYAPKH----TIFESLEELQAYEVDPAQTYFLAAQTTQDRESFDTI 176 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + LR + D IC AT +RQE VR L+ + + +++VG KNS N+ RLA++AQ Sbjct: 177 REYLRANVDAAMT-ILDTICMATKDRQEEVRELSRKVQAIVIVGGKNSGNTRRLAQIAQE 235 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 G A ++ A+++ E + +G+TAGAS P ++QNV L+ Sbjct: 236 SGIFAIHVETAEELPLEELAAFTRIGLTAGASTPPWIIQNVAQTLRLAFPD 286 >UniRef50_B2KBE4 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBE4_ELUMP Length = 564 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 85/283 (30%), Positives = 147/283 (51%), Gaps = 8/283 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + +A GFC GV +AI V + PI+ ++HN V+ +L E+G I SE Sbjct: 8 VTIAKSAGFCPGVKKAIDKVLELESSGKKPIFTLGPLIHNNQVIATLEEKGITSIGHPSE 67 Query: 63 VP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 V +L+ AHG++ + E +S V DATCPLV VH +++ + G ++++G Sbjct: 68 VEGKEGVLVIRAHGITPEFQREVESCGKEVIDATCPLVKHVHNNISKYAGEGYTTVIVGD 127 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 AGH EV G +G +G Y+V +V L + + +K++ + QTT + + + Sbjct: 128 AGHAEVIGLLGY---TQGRGYVVADESEV--LALPDFDKVNIVAQTTQKEAAFYKLAELI 182 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 +++ + V + IC T RQ A+ A+ V+VVG KNS+N+ RLA+L + + Sbjct: 183 KQKAKEAV--VSNTICEPTKQRQSETIEYAKNADFVIVVGGKNSANTARLAKLCGELAPK 240 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 ++ D++ +K K + +TAGAS P+ L+ + ++ Sbjct: 241 VLHVETEADLEGHDLKTPKKIFITAGASTPNWLIDRISGAVKN 283 >UniRef50_C1QCD1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Brachyspira murdochii DSM 12563 RepID=C1QCD1_9SPIR Length = 583 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 140/300 (46%), Gaps = 10/300 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVEN--ALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M + + GFC GV A+ + A IY+ ++HN +D L G E Sbjct: 1 MNVDIGKFAGFCDGVKYAVENTFSQAAKNNNNDDIYIDGHLIHNPQTLDMLENIGVKTYE 60 Query: 59 QISE--VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEES 116 + V + +I AHG+S R S + + TC V K+ V + S G Sbjct: 61 DNEDMSVLNNKTVIVRAHGISPKRREALSSHAKKIVNLTCKYVAKIQGLVKKHSSLGYRI 120 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 I+IG+ HPE+ G G ++ +Y+V +D+ L + +K QTTL Sbjct: 121 IVIGNPKHPEIIGVCGYAND----VYVVYKDEDLNNLP-NDTKKTLIAAQTTLQKSVFDK 175 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 +D +++++P K+ IC AT RQ V +A++ + VLV+G SSN+ L +A Sbjct: 176 YVDKIKEKYPDTEIIVKNTICEATEQRQNEVLEIAKRNDAVLVIGGSESSNTRNLYNIAS 235 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGR 296 + K AF ++ +D+++ + + K VG+ AGAS PD L+++V ++ R Sbjct: 236 SI-KPAFYVEYKEDLEKIDLSKYKNVGIMAGASTPDWLIEDVAQTIKDKYASPITRFVSR 294 >UniRef50_B1GYQ1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYQ1_UNCTG Length = 300 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 84/303 (27%), Positives = 154/303 (50%), Gaps = 16/303 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +++ +A GFC GV RAI + E +Y V+HN V L ++G ++ Sbjct: 7 LRVKIAENAGFCFGVRRAIDLTEKTAGK-ERKVYTLGPVIHNPQEVKRLEKKGIKTLKDP 65 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKS-RDLTVFDATCPLVTKVHMEVARAS----RRGEE 115 +V G+I I HG+ + + + +++ V DA CP V + + R S + + Sbjct: 66 KKVKSGSI-ILRTHGIPCNLHKKLEENKNINVIDAACPFVKRAQNTIKRLSTDIKSKDKT 124 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 I++G HPEV + G +VE+ + K + L+ ++QTT + ++ + Sbjct: 125 IIVVGEKIHPEVIALVSY---GSGKCIIVENIKEAQK--FRGRGDLNIVSQTTQTPENFN 179 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 +I L+KR+ + IC AT +RQ+A LA+ ++++V+G KNS N+ RLA++ Sbjct: 180 SIIKVLKKRYK---TKVYNTICKATLDRQKAAEKLAKNVDLMIVIGGKNSGNTTRLAQIC 236 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG 295 + + I+ A I+E+W K + VG+TAGAS PD +++ + R++++G + Sbjct: 237 SEK-TKTYHIETACSIKEKWFKNINSVGLTAGASTPDWIIKEIEMRIKEVGAKHYLEFIS 295 Query: 296 REE 298 + Sbjct: 296 AAD 298 >UniRef50_B1C7U3 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1C7U3_9FIRM Length = 666 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 154/301 (51%), Gaps = 11/301 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I A G+C GV++A++ A +Y ++HN +V + L+E+G I+ + Sbjct: 1 MNIRKAKSAGYCFGVNKAVNTAYEASENSNEKVYTLGPLIHNVHVTNELKEKGVSIIDNL 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 ++ +G +I +HGV + + + K ++L + DATCP V + +V + +G I++G Sbjct: 61 DDIDEG-TVIIRSHGVGKEIYEKIKKKNLKLIDATCPYVKSIQNKVEKYHNKGYTIIIVG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 + HPEV+G G N ++ + ++ K +E + + QTT+ D+ + Sbjct: 120 DSDHPEVKGVNGWCEN---KAKVIFTKEEAKN--FKTDENVCVVAQTTIIEALFDDITNI 174 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 ++ +V + IC AT+ RQE +A + E ++VVG +SSN+ +L E+++ Sbjct: 175 IKDNCANVV--IFNTICNATSVRQEEASLIASEVEAMVVVGDTHSSNTKKLVEISKSKCD 232 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 F ++ A D+ + +K+ +G+TAGAS P L++ V+ + + EE+I Sbjct: 233 NVFFVETASDLD-DAIKKYNNIGLTAGASTPTQLIEEVINTMDNNMVDSFE--KNIEESI 289 Query: 301 V 301 Sbjct: 290 K 290 >UniRef50_B1ZXD4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Opitutus terrae PB90-1 RepID=ISPH_OPITP Length = 289 Score = 316 bits (811), Expect = 5e-85, Method: Composition-based stats. Identities = 91/296 (30%), Positives = 156/296 (52%), Gaps = 18/296 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M++L A GFC GV+RAI I + P+Y ++HNR +++ L E G + Sbjct: 1 MKVLRAKSAGFCWGVERAIEITRDYAHQGRKPVYTDGPLIHNRQMMEKLSEEGIREVGDY 60 Query: 61 SE----------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARAS 110 + +++ AHG+S RN KS + DATCP V + ++ + Sbjct: 61 QSRANIAVNPAAPGENPVMVVRAHGISPERRNYLKSLGMDFKDATCPDVGIIAGKIRLHA 120 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLS 170 ++G +I+ G HPE G +G EG Y + S D+ L E++ ++Q+T+ Sbjct: 121 KKGYATIIFGDKNHPEAIGLLGY---TEGRGYCITSKADIDALPA--LERVCMVSQSTMF 175 Query: 171 VDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSN 229 + + +++ + R++F ++ D IC AT +RQ V ALA Q A+ ++V+G +S+N+ Sbjct: 176 MHEFAELSEYARQKFKEV--LVFDTICQATKDRQTDVVALARQGAQAIVVIGGHHSANTV 233 Query: 230 RLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +LA LA+ + I+ A ++ E +K+ +GVTAGAS P+ L+ V A+L+ L Sbjct: 234 KLASLARLQNLPTYHIETAAELSPEEMKKFTVIGVTAGASTPEFLISEVCAKLEAL 289 >UniRef50_C7RHT6 Hydroxymethylbutenyl pyrophosphate reductase n=8 Tax=Clostridiales Family XI. Incertae Sedis RepID=C7RHT6_ANAPD Length = 686 Score = 315 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 86/309 (27%), Positives = 159/309 (51%), Gaps = 12/309 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++AN GFC GV R++ + E A+ G Y ++HN +V+ L G +++ Sbjct: 1 MEIIIANYSGFCGGVRRSVELAEEAIKNEGER-YCVGPLIHNPQLVEKLENEGLEVVDKK 59 Query: 61 SEVP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + + ++ AHG S + + V DATCP++ ++ ++ G + +++ Sbjct: 60 EALKIKDSTVLIRAHGESADFKERLLANGNEVVDATCPVLNNIYKKIIEKENDGYQVVIV 119 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPE+ +N +V + + K KL ++QTT +D D+ + Sbjct: 120 GDKTHPEIIAMESFLNN----GIIVSDETEAKNI--KCNNKLYVVSQTTNRLDYFYDIAN 173 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L++ +V + IC AT NRQEA ++LA++ + ++V G NSSN+N+L ++A Sbjct: 174 KLKENNDSVVIE--NTICKATENRQEAAKSLAKEVDCMIVAGGFNSSNTNKLYQVANLYC 231 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREEN 299 K F I+ KD+ + + + K VG+ AGAS PD +++ VV+ + + + + E++ Sbjct: 232 KNVFRIETVKDLPLQKLSKFKKVGIIAGASTPDEIIEEVVSSMDEF--TKEEFMNSLEDS 289 Query: 300 IVFEVPKEL 308 + PKE+ Sbjct: 290 LKKIYPKEI 298 >UniRef50_C9D092 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Alphaproteobacteria RepID=C9D092_9RHOB Length = 556 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 133/228 (58%), Positives = 178/228 (78%), Gaps = 2/228 (0%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 + LA PRGFCAGVDRAI IVE AL +GAP+YVRHE+VHN++VVD LR++GA+F+E++ E Sbjct: 9 LYLAAPRGFCAGVDRAIKIVEMALEKWGAPVYVRHEIVHNKFVVDGLRDKGAVFVEELEE 68 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 PD +IFSAHGV ++V A++R++ DATCPLV+KVH+E R + G + I+IGH Sbjct: 69 CPDDRPVIFSAHGVPKSVPAAAQAREMVFVDATCPLVSKVHIEAQRHAEAGLQMIMIGHK 128 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 GHPE GTMGQ EG + LVE+ +DV + V++ E+L+F+TQTTLSVDDT D++ AL+ Sbjct: 129 GHPETIGTMGQLP--EGEVLLVETVEDVAHVDVRDPERLAFVTQTTLSVDDTKDIVAALQ 186 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 RFP I+GP K+DICYATTNRQEAV+ +A +++ +LVVG+ NSSNS R Sbjct: 187 TRFPAIIGPHKEDICYATTNRQEAVKEVAPKSDALLVVGAPNSSNSRR 234 >UniRef50_B9L0U3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Thermomicrobia (class) RepID=B9L0U3_THERP Length = 327 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 94/303 (31%), Positives = 140/303 (46%), Gaps = 15/303 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I++A GFC GV RA+ IV NA P+ +++HN VV+ L G + + Sbjct: 16 EIVVAEVLGFCWGVRRALEIVRNAARE--RPVAALGDIIHNPIVVEQLTREGVLPVTDPV 73 Query: 62 EVPDG--AILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 E + +AHG EA DL V D TCPLVTKV + + +G ++ Sbjct: 74 EAKRHGLDRVAITAHGAPPTRYQEASVYDLEVIDTTCPLVTKVQRLAQKLALQGYFLVVY 133 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVW-------KLTVKNEEKLSFMTQTTLSVD 172 G A HPEV G +G +S DD+ K++ + QTT D Sbjct: 134 GDAQHPEVRGVLGWAGTERACA--AKSFDDLPWDGPRGTGAMQPPPRKVALIAQTTKRTD 191 Query: 173 DTSDVIDALRKRF--PKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNR 230 + + AL + IC T RQEA+ LA ++VLV+G + SSNS R Sbjct: 192 EFTAFAQALAAWVLPHGGELRVVNTICQPTWERQEALARLARTVDLVLVIGGRKSSNSAR 251 Query: 231 LAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 L E+++ +G + L++ + V+ VG+TAGAS PD ++ V+ L +LG Sbjct: 252 LVEVSRSLGTPSVLVERPDQLDPALFAPVRRVGITAGASTPDEVILAVIEELVRLGFAPP 311 Query: 291 IPL 293 L Sbjct: 312 QRL 314 >UniRef50_C7LZW7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZW7_ACIFD Length = 344 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 118/312 (37%), Positives = 179/312 (57%), Gaps = 10/312 (3%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA PRGFCAGV+RAI + L I+ P+Y HE+VHNR VV++ G +F++ + Sbjct: 5 KVLLAAPRGFCAGVERAIGALGWMLRIFEPPVYCYHEIVHNRLVVEAFEAAGVVFVDDVE 64 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 VP G ++ SAHG + V A+ R V DA CPLVTKVH E+ ++RG + + +GH Sbjct: 65 SVPPGRPVMLSAHGTAPEVLEAARQRCPIVVDAVCPLVTKVHHEIRTRAQRGYQIVYVGH 124 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E G + + VE+P++ +T+ + ++ + QTTL+V + + + Sbjct: 125 RGHEEAIGATAEAP---EAVTFVETPEEARAITL-GDGPVALLAQTTLAVPEWEAIAAIV 180 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK- 240 + P + P + D+CYATTNRQ AVRALAE+ + ++VVGS NSSN+ L +A G Sbjct: 181 ASQTPNLWQPGRSDLCYATTNRQAAVRALAERVDAMVVVGSANSSNTRALERVATSAGVG 240 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENI 300 ++ ++ + VGVTAGASA + +V++VVA L G + EE+ Sbjct: 241 HVERVNRPSELVGPF---EGIVGVTAGASAAESVVKDVVAALAPRLG--VEEISVLEEDE 295 Query: 301 VFEVPKELRVDI 312 F +P +LR I Sbjct: 296 FFPLPPDLRDLI 307 >UniRef50_C9M529 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M529_9BACT Length = 289 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 10/286 (3%) Query: 1 MQIL--LANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M + A P G C GV RAI+ +E AL+ G +Y +HN + L ++G + Sbjct: 1 MTVRFSKAEPTGLCFGVKRAIAQMEKALSSDGE-LYCVGSPIHNPQEIARLAQKGLRVVA 59 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 +VP G+ + AHG++ +RN K R++ + D TCP V G ++ Sbjct: 60 SPQDVPSGSTVFIRAHGIAPDLRNALKQRNVRIIDGTCPFVRVAQARAKALEDEGYSVVV 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 G A HPEV +G + G +V + D+ L E++ F++QTTL D + ++ Sbjct: 120 AGDASHPEVISIVG---GLQNGAKVVSNSTDLQDLA--KIERIGFVSQTTLPEDLFASIV 174 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 A + P + + IC AT RQ AV L ++ + ++V+G ++S+N+ +L +A+ Sbjct: 175 SAAVRISPDV--KAHNTICRATFERQRAVAELVKRTDGIVVIGGRDSANTAKLFHIAKSC 232 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 G I++A ++ +W VG+ AGAS PD L++ + +Q Sbjct: 233 GADVLWIEEAGELDGKWFTGKTHVGIAAGASTPDWLIEEFIQAARQ 278 >UniRef50_B8CWY2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CWY2_HALOH Length = 678 Score = 313 bits (802), Expect = 6e-84, Method: Composition-based stats. Identities = 74/266 (27%), Positives = 130/266 (48%), Gaps = 8/266 (3%) Query: 32 PIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTV 91 P+Y ++HN VV L+E G ++ + + +G ++I +HGV + +A+ + L + Sbjct: 12 PVYTLGPLIHNPQVVKRLKEMGIESLDSLDIIDNG-VIIIRSHGVPPDIIEKARQKGLHI 70 Query: 92 FDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVW 151 DATCP V +G ++I+ G HPEV G G N ++ S ++ Sbjct: 71 IDATCPYVKNAQKYARELVDKGYQTIIFGDRDHPEVIGINGAARNES---IIISSEKEIK 127 Query: 152 KLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALA 211 + + + K+ + QTT S ++ + ++ + IC T RQ++ LA Sbjct: 128 DINLSS--KVGLIAQTTKSPASFQKIVSYILPEVKEL--RIYNTICRTTETRQKSAVDLA 183 Query: 212 EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAP 271 Q + + V+G KNS+N+ RLAEL G + I+ A +I +K +G+TAGAS P Sbjct: 184 RQVDAMFVIGGKNSANTTRLAELCAETGTPTYHIETAGEIDFRQLKSYNKIGITAGASTP 243 Query: 272 DILVQNVVARLQQLGGGEAIPLEGRE 297 D L++ V+ + + + E +E Sbjct: 244 DWLIKEVIEAMSEEKRDAELQEEIQE 269 >UniRef50_B7JN13 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=72 Tax=Bacillales RepID=ISPH_BACC0 Length = 316 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 114/315 (36%), Positives = 172/315 (54%), Gaps = 15/315 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M+I+ +PRG+C GV A+ I NA PIY+ +VHN++V D+ E G I ++ Sbjct: 1 MKIVKISPRGYCYGVVDAMVIARNAALDTSLPRPIYILGMIVHNKHVTDAFEEDGIITLD 60 Query: 59 QISEVP-----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 S + D +IF+AHGVS V+ AK + LT DATCP VTK H + G Sbjct: 61 GPSRLDILDKIDSGTVIFTAHGVSPEVKQRAKEKGLTTIDATCPDVTKTHDLIEAKKAEG 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 I IG HPE EG +G + ++L+E DD+ L + +K+ QTT+S D Sbjct: 121 YHVIYIGKKNHPEPEGAVGIAPDI---VHLIERADDLKTLEIP-TDKILVTNQTTMSQWD 176 Query: 174 TSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +++ ++K+FP +IC AT RQEAV A+ A++ +VVG S+NSNRLA+ Sbjct: 177 VQHLMEDIQKKFPTAEF--HKEICLATQVRQEAVAKQADVADLTIVVGDPKSNNSNRLAQ 234 Query: 234 LAQR-MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 ++Q G +A+ + D +I EW++ V+ V VTAGAS P + + V+A L+Q Sbjct: 235 VSQEIAGTKAYRVADVSEINLEWLQGVENVAVTAGASTPTPITKEVIAFLEQYDPMNPAT 294 Query: 293 LE-GREENIVFEVPK 306 E R+ + +P+ Sbjct: 295 WERVRKVPLQKILPR 309 >UniRef50_C1KV98 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=48 Tax=Firmicutes RepID=ISPH_LISMC Length = 331 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 112/325 (34%), Positives = 181/325 (55%), Gaps = 19/325 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENAL--AIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE 58 M+I+ +PRG+C GV A+ I +NA PI++ +VHN++V D+ G ++ Sbjct: 1 MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVD 60 Query: 59 Q------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + ++ G +IF+AHGVS +V+ +A ++ LT DATCP V + + Sbjct: 61 GANREEILDKITTG-TVIFTAHGVSPSVKAKAAAKGLTTIDATCPDVLHTYNLILEKQAA 119 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G E I IG GHPE EG G + ++LVE+ D+ L++ + + QTT+S Sbjct: 120 GYEIIYIGKKGHPEPEGAYGTAPD---VVHLVETKADIDALSL-LSDNIFVTNQTTMSKW 175 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D +D++D ++++FPK + +IC AT RQEAV A+ A++ +VVG S+N+ RLA Sbjct: 176 DVADLMDYIKEKFPKAIQ--HQEICMATQVRQEAVAVQAKGADLTIVVGDPRSNNTARLA 233 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +++ ++ G +A+ I D ++ EW+K+ K V VTAGAS P LV+ V+ L+Q + Sbjct: 234 QVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKT 293 Query: 292 PLEGREENIVFE--VPKELRVDIRE 314 + R N FE +PK + E Sbjct: 294 TWK-RAHNKDFERILPKMKNKYMAE 317 >UniRef50_Q8RI52 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=19 Tax=Fusobacterium RepID=ISPH_FUSNN Length = 827 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 85/303 (28%), Positives = 159/303 (52%), Gaps = 13/303 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--- 57 M+I+ A GFC GV AI++ + + G Y+ +VHN+ VV+ + +G + Sbjct: 1 MEIIRAKHMGFCFGVLEAINVCNSLVEEKGRK-YILGMLVHNKQVVEDMERKGFKLVTED 59 Query: 58 ---EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + E+ + I++ AHG S++V + K R + VFDATC V K+ E+ A+ G Sbjct: 60 ELLNDMDELKEDDIVVIRAHGTSKSVHEKLKERKVKVFDATCIFVNKIRQEIEIANENGY 119 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 + +G HPEV+G + + + + ES ++ KL + ++ TQTTL+ Sbjct: 120 SILFMGDKNHPEVKGVISFADD----IQIFESFEEAKKLKIDLDKTYLLSTQTTLNKKKF 175 Query: 175 SDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 ++ ++ + +V D IC AT RQ+AV LA + EV+++VG SSN+ +L E+ Sbjct: 176 EEIKKYFKENYKNVV--IFDKICGATAVRQKAVEDLAVKVEVMIIVGDTKSSNTKKLYEI 233 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE 294 ++++ ++L+++ + + + + VG+TAGAS P+ + N+ +++ + + Sbjct: 234 SKKLNDNSYLVENEEQLDLSIFRGKEVVGITAGASTPEETIMNIEKKVRGIYKMSNVNEN 293 Query: 295 GRE 297 E Sbjct: 294 QNE 296 >UniRef50_D1Y3T0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y3T0_9BACT Length = 293 Score = 309 bits (792), Expect = 9e-83, Method: Composition-based stats. Identities = 95/289 (32%), Positives = 145/289 (50%), Gaps = 6/289 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+IL+A P G C GV RAI VE ALA AP+Y +HN V+ L++ G ++ Sbjct: 1 MKILVAAPTGLCFGVKRAIGFVEKALAQ-TAPVYALGSPIHNPQEVERLQKMGLRVVQSE 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +E+P GA + AHG + V + R+++V D TCP V S G +++G Sbjct: 60 TEIPAGATALIRAHGAAPGVLENLRKRNVSVIDGTCPFVRAAQGHARELSEAGYHVLILG 119 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESP--DDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 + HPE G G P + + S ++K +VK KL ++QTT +++ Sbjct: 120 NEKHPETVGIRGYVRGPSTVISTIPSLFSSTIFKSSVKIH-KLGLVSQTTQ--EESLLAE 176 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 A + IC AT RQEAVR LA Q E ++V+G NS+N+ +L +A+ Sbjct: 177 AAKAALGVADELRIYNTICRATIERQEAVRRLASQVEGMIVIGGHNSANTGKLCRIARDS 236 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 A I+ A + WV E + +G+ AGAS PD L++ + + + G Sbjct: 237 SCDAVWIEHAGQLDRRWVLEKRVIGIAAGASTPDWLIEQLHNAIHNIAG 285 >UniRef50_Q72G08 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Desulfovibrionales RepID=ISPH_DESVH Length = 290 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 130/294 (44%), Gaps = 13/294 (4%) Query: 1 MQILLANPRGFCAGV-------DRAISIVENALAIYGAP--IYVRHEVVHNRYVVDSLRE 51 M ++ A GFC GV DR + E A I ++HN V+++ Sbjct: 1 MNVIRARTAGFCMGVSLALRKLDREVDRAEEKAAQGSPRCRIATFGPIIHNPQVLEAYAG 60 Query: 52 RGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 G + Q+ EV G ++ AHGV Q +SRD V DATCP V K + + R Sbjct: 61 MGVRCLRQVDEVEAGDHVVIRAHGVPQQQEKALRSRDAVVVDATCPKVKKAQLGIEEQCR 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G +L G A HPEV G + G + S D++ L ++ E + QTT Sbjct: 121 AGRTLLLFGEAEHPEVRGLLSYAG---EGALVFGSVDELEGLPLQPETEYFLAAQTTQDR 177 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 L +R P + IC AT RQ+ +A + + ++VVG +S N+ RL Sbjct: 178 VAFEVARAWLHERLGH-EVPVLETICDATRLRQQEAIDIARKVDAMVVVGGFDSGNTRRL 236 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 A++A G +++ + E ++ +G+TAGAS P ++ L+ L Sbjct: 237 ADVAAAQGVFTVHVENESQLPVEQLRGCGIIGLTAGASTPKSIIDATQRFLESL 290 >UniRef50_B5YEC2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Dictyoglomus RepID=ISPH_DICT6 Length = 283 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 91/290 (31%), Positives = 152/290 (52%), Gaps = 10/290 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + +A P GFC+GV ++IS+ E L+ G +Y +VHN V++ L ++G +E+ Sbjct: 1 MILYIATPYGFCSGVKKSISLAEKVLSNEGE-VYTLGALVHNPKVIEELSKKGIKILEKN 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V +G LI AHG+ Q ++ V+DATCPLV KV + ++ + ++IG Sbjct: 60 GFV-EGKALIVRAHGLPQRDIEFYRTLGNRVYDATCPLVKKVQILAEYLNKNKYKVVIIG 118 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV G + + +VE+ DD+ K+ K+ + QTT S+D+ ++ Sbjct: 119 EKNHPEVIGILSYTDD---QGIVVENEDDIKKIENYP--KIGIVFQTTQSLDNALQKVNL 173 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + ++ +I + IC T RQE + L+E ++ LV+G KNS+N+ RL + Sbjct: 174 IMEKGKEI--RIFNTICPETIERQEKAKKLSEMVDLALVLGGKNSANTRRLY-ITLSKKI 230 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEA 290 + I++ ++I + W KE VG+ G S P+ V+ VV L+ L E Sbjct: 231 PTYHIENIEEIDKSWFKEDNKVGIITGTSTPNDFVEEVVELLKSLYPLEI 280 >UniRef50_B9MRX3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MRX3_ANATD Length = 663 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 98/288 (34%), Positives = 149/288 (51%), Gaps = 7/288 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVE-NALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV RA+ V A A G I V ++HN YV+D L++ G +E Sbjct: 1 MIIKVAQSAGFCFGVQRAVEGVLAWAKANKGKSIKVYGMLIHNSYVIDKLKDLGVKVVED 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I ++ I+ +HGVS E + R V+D TCP V K+H V S G + I++ Sbjct: 61 IEQIGKEDIIFIRSHGVSMEEYAEIEKRADKVYDFTCPYVKKIHEIVMEHSVNGYDIIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G +G N ++V+S + V + + E K + + QTT S++ + Sbjct: 121 GDMNHPEVKGIVGHVGN-NRKCFVVDSIEKVKEAINQIEGKAAVVCQTTFDGKKWSEIRE 179 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 L D IC AT NRQ+ + LA+ +++LVVG K SSN+N+L +L + + Sbjct: 180 FLESH---TNYKVFDTICKATINRQKEAQELAQHVDIMLVVGDKKSSNTNKLYKLLKEI- 235 Query: 240 KRAFLIDDAKDIQEEWVKEV-KCVGVTAGASAPDILVQNVVARLQQLG 286 K F I+ +D+ + K +GVTAGAS ++ VV L++ Sbjct: 236 KPTFFIEKVEDLDSIKLDSYIKSIGVTAGASTSPEQIEEVVKHLEEKF 283 >UniRef50_D1VSI0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VSI0_9FIRM Length = 725 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 89/292 (30%), Positives = 145/292 (49%), Gaps = 13/292 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA+ GFC GV RA + A +Y ++VHN V++ L+E+ IE Sbjct: 1 MEIYLADYAGFCGGVKRACKLAFAAADEG---VYCLGDIVHNEVVINDLKEKKVKTIENT 57 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + +I +HGV + + + + + D CP V K++ V + ++G I++G Sbjct: 58 QVY--NSKVIIRSHGVPKEDLEKLRYNNNEIIDCVCPKVKKIYNIVEKYYKKGYNIIIVG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPEV+G +N + +D+ K + Q+T S + D + Sbjct: 116 DENHPEVKGINSYCNNE---AIIFNKEEDLK----VPVGKTIVVAQST-SNEKVFDYLTN 167 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L K K + IC AT NRQ ++R LA+ + V+V+G K SSN+ +LAE+A+ K Sbjct: 168 LIKNISKSEILVYNTICDATFNRQNSIRKLAKIVDAVIVLGGKKSSNTKKLAEVAKESCK 227 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 FLI KDI +K+ +G+TAGAS PD +++ V+ ++ GE + Sbjct: 228 NVFLIQSIKDIDINILKKFNKIGITAGASTPDKVIKEAVSSMENFDKGEMME 279 >UniRef50_C8WAL7 Hydroxymethylbutenyl pyrophosphate reductase n=3 Tax=Coriobacteriaceae RepID=C8WAL7_ATOPD Length = 284 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 156/288 (54%), Gaps = 9/288 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I +A+ G C GV+RA+ +V+ A+ AP+ ++HN VV SL+++G ++ SE Sbjct: 4 IKIADEAGACYGVERALQMVQQAVKDAHAPVRTLGPLIHNPRVVTSLKDQGVEVVDFASE 63 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 G+ L+ HGV+ AK + V DATCP V K H +++G ++G + Sbjct: 64 -AAGSALLLRTHGVTPQEEQIAKDGCVDVLDATCPFVKKAHRAAELLAKQGYAVYVVGES 122 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLT--VKNEEKLSFMTQTTLSVDDTSDVIDA 180 GHPEVE T+ ++S ++V ++ +K+ + QTT+S S+V++A Sbjct: 123 GHPEVEATLAHVPGS----LAIDSVEEVAAQADAMRVAKKVGLVVQTTMSAAKLSEVVNA 178 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 + ++ + IC AT Q++ LA++++V++++G + S+N+ RLAE+++ Sbjct: 179 VLPLVDEL--RVMNTICEATAGHQDSCMRLAKESDVMIIIGGRISANTTRLAEISKLYCP 236 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 + I+ ++Q W + + +G+TAGAS P+ + V ++++ G Sbjct: 237 ATYHIEGTDELQASWFEGAEHIGITAGASTPEAHINAVKLAIEEIVGA 284 >UniRef50_B9XIS3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=bacterium Ellin514 RepID=B9XIS3_9BACT Length = 297 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 93/288 (32%), Positives = 143/288 (49%), Gaps = 9/288 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M I+ A G C GV AI++ P+ + ++VHN V+ +LR G F ++I Sbjct: 14 MNIIRAEHMGMCFGVRDAITLA--TKETASTPLTILGDLVHNETVLSNLRAHGIKFEQEI 71 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 V + ++ +AHG S+ NE K+R L V +ATCPLV H VA +R G ++IG Sbjct: 72 EAVTTDS-VMITAHGASEKSINEIKARGLKVLEATCPLVHFAHRSVAELARDGYHPVIIG 130 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 H EV G G + +V S D+ L + + QTT ++ ++ Sbjct: 131 KRDHVEVRGLTGDLKAFD----VVLSEADIENLQER--ARFGIAAQTTQPIEKVQRLVGI 184 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 +RK+FP D +C T RQ A LA++++VV+VVG +S+N++ L + R Sbjct: 185 VRKKFPNSEVRFVDTVCRPTKQRQFAAVELAQKSDVVVVVGGAHSNNTHELVKTCGRYCP 244 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 R + A D++ EW + VG+TAG S PD + V L+QL Sbjct: 245 RVHHVQFANDLRSEWFENAGIVGITAGTSTPDSTINEVEQALRQLADN 292 >UniRef50_B0MQU3 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B0MQU3_9FIRM Length = 658 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 148/311 (47%), Gaps = 17/311 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 I A GFC GV RA+ I E G+ Y E++HN + L++ G I+ Sbjct: 5 NIETAKSAGFCFGVKRAVEIAEKTAEENGS-CYTLGELIHNGSEIARLQKLGVYPIDSPD 63 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 ++P G LI +HGV+++V + + ++ DATCP V K+H V S+ I+ G Sbjct: 64 DLPQGRTLIIRSHGVAKSVTDYIHDKGISCIDATCPFVAKIHNIV---SKSECPVIIAGD 120 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL----TVKNEEKLSFMTQTTLSVDDTSDV 177 HPEV G +G NP+ + +V D++ K+ + L + QTT + Sbjct: 121 PDHPEVIGIVGHCRNPDE-VSVVRDSDELEKMAELQKFPRQNALIMVAQTTFNSSKWQSC 179 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I +K + I D IC AT RQ+ LA ++ +++ VG KNSSN+ +LA+++Q+ Sbjct: 180 IQVAKKHYTNIT--IFDTICSATAERQKETEELARRSALMVTVGGKNSSNTAKLAQISQK 237 Query: 238 MGKRAFLIDDAKDIQEEWVKE-----VKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 D DI + V E VG+TAGAS P +++ V + ++ E Sbjct: 238 HC-PVIFTQDGSDIDKAAVSELLPLQGGTVGITAGASTPAYIIKEVHRIMSEILNNEEGF 296 Query: 293 LEGREENIVFE 303 E + F+ Sbjct: 297 DFMAEVDKTFK 307 >UniRef50_UPI00016C0033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0033 Length = 284 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 145/290 (50%), Gaps = 9/290 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISE 62 I LA GFC GV+RA+++ + ++ I+ ++HN +V + L+ +G +++ Sbjct: 2 IKLAKSAGFCFGVERAVNLAYSNASLSN--IFTFGPIIHNDFVTNDLKLKGVEIAYELT- 58 Query: 63 VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHA 122 P +I +HGV + + +A + + DATCP V K+H V + G+ I+IG Sbjct: 59 -PRIKNVIIRSHGVGENIYKQADHLGINIIDATCPYVKKIHNLVKQHIILGQSIIIIGDK 117 Query: 123 GHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALR 182 HPE+ G G ++ +++ D + N + + QTT + + +I L Sbjct: 118 LHPEIIGINGWTNDN---AIIIKDEFDSNIPLLDNTKSYFVVAQTTYKQEVVNRIIQLLE 174 Query: 183 KRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRA 242 + I IC TT RQ+ R+LA+ + +++VG +NSSN+ +L E+ K + Sbjct: 175 EN--HITFNYVHTICSTTTKRQQEARSLAKNVDTMIIVGGRNSSNTKKLFEICLSECKNS 232 Query: 243 FLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 I++A ++ + + +G+TAGAS P ++ +V++ + GE Sbjct: 233 LCIENASELAKIKFNKDSDIGITAGASTPKYIIDDVISYINNTIKGEISN 282 >UniRef50_A4XKP1 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XKP1_CALS8 Length = 662 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 87/287 (30%), Positives = 142/287 (49%), Gaps = 6/287 (2%) Query: 1 MQILLANPRGFCAGVDRAISIVE-NALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M I +A GFC GV+RA++ V A A + V ++HN YV++ L+E IE Sbjct: 1 MIIKVAKNAGFCFGVERAVNGVIAWAKANKDKSVKVYGMLIHNSYVIEKLKELNVKVIEN 60 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I+E+ I+ +HGVS +E + R V+D TCP V K+H V S G + I++ Sbjct: 61 INEIEKDDIVFIRSHGVSMEEFSEIEKRASKVYDFTCPYVKKIHEIVRENSENGLDVIVV 120 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G HPEV+G +G + +++S + + + QTT ++ + Sbjct: 121 GDINHPEVKGIIGHVEK-DRKCIVIDSLEKAKDAISQLGRNAVVVCQTTFDNAKWCEIKE 179 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + D +C AT RQE + LA +V+LV+G K SSN+N+L + + + Sbjct: 180 YIEN---NTEYKVFDTVCKATITRQEEAKVLALDVDVMLVIGDKKSSNTNKLYQAVKDI- 235 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 K F I+ +D++ +VK +G+TAGAS + +V L++ Sbjct: 236 KPTFFIERPQDLEGIDFTKVKKIGITAGASTSQEQISEIVEILEKRF 282 Score = 41.2 bits (96), Expect = 0.048, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 70/197 (35%), Gaps = 18/197 (9%) Query: 12 CAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSL----RERGAIFIEQIS------ 61 C V + IV G + V ++ H V + ++R I I+ + Sbjct: 97 CPYVKKIHEIVRENSEN-GLDVIVVGDINH-PEVKGIIGHVEKDRKCIVIDSLEKAKDAI 154 Query: 62 -EVPDGAILIF-SAHGVSQ--AVRNEAKSR-DLTVFDATCPLVTKVHMEVARASRRGEES 116 ++ A+++ + ++ ++ ++ + VFD C E + + Sbjct: 155 SQLGRNAVVVCQTTFDNAKWCEIKEYIENNTEYKVFDTVCKATITRQEEAKVLALDVDVM 214 Query: 117 ILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 ++IG Q + +E P D+ + +K+ + S + S+ Sbjct: 215 LVIGDKKSSNTNKL-YQAVKDIKPTFFIERPQDLEGIDFTKVKKIGITAGASTSQEQISE 273 Query: 177 VIDALRKRFPKIVGPRK 193 +++ L KRF +I Sbjct: 274 IVEILEKRFNQIDNQDF 290 >UniRef50_C5H8E3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Dunaliella salina RepID=C5H8E3_DUNSA Length = 474 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 86/358 (24%), Positives = 147/358 (41%), Gaps = 67/358 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIE--- 58 + LA G+C GV+RA+ + A + G I+V +E++HN V LRE ++ Sbjct: 112 VKLAKAYGYCWGVERAVRMAYEARRAFPGRSIHVTNEIIHNPEVNRRLREMDVNIVKEDP 171 Query: 59 ----QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 S++ +G ++IF A GV + + + + D TCP V KV V +++ Sbjct: 172 QKGKDYSKIDNGDVVIFPAFGVGAPDMKYFRDKGVNIVDTTCPWVAKVWNSVDTYAKKKC 231 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEE--------------- 159 SI+ G H E T + +++ ++ + + Sbjct: 232 TSIIHGKYSHEETVATASFAEDY----LIIKDLNEAQYVCDYILKGGDREEFMKKFSKAV 287 Query: 160 -----------KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYAT 200 ++ QTT+ +T + L + + GP D IC AT Sbjct: 288 SKGFDPDVHLNRVGLANQTTMLKGETQAIGKMLERTMMEKFGPQNLQDHFMVMDTICDAT 347 Query: 201 TNRQEAVRALA--EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ------ 252 RQ+A+ + +++LVVG NSSN++ L E+ G AF +D A I Sbjct: 348 QERQDALYEITDDPTIDMMLVVGGFNSSNTSHLQEIPHNKGLPAFWVDTADRIDMASNSI 407 Query: 253 ------------EEWV-KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 E W+ + +GVT+GAS PD V+ V+ R+ ++ ++ RE Sbjct: 408 AHKLHYGELKVTENWLPEGPITIGVTSGASTPDRAVEEVLERVFRMKDPNFKGIQPRE 465 >UniRef50_Q73NQ6 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema denticola RepID=ISPH_TREDE Length = 289 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 138/295 (46%), Gaps = 18/295 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAP---IYVRHEVVHNRYVVDSLRERGAIFI 57 M + A G+C+GV RA+ V +Y ++HN + L++ G I Sbjct: 1 MVVKRAEVLGYCSGVRRAVDTVLKLAKENTENKSGLYTFGPLIHNPSTMLRLKQMGVRTI 60 Query: 58 EQI----SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 + E ++++ AHG+ + ++E + V DATC V + S Sbjct: 61 DTENFTEDEDYKDSVIVIRAHGIPPSKKSELEKSGAKVIDATCSRVKASQALAKKHSEEA 120 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKN----EEKLSFMTQTTL 169 IL G H E+ G EG +V++ ++ + + + + QTT+ Sbjct: 121 F-VILAGDKNHGELISIAGYA---EGKCLIVQNAEEAALIDLPSSLSANGSAVLIAQTTI 176 Query: 170 SVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSN 229 + + AL+KR + + IC AT++RQ A++ LA + + +LV+G KNS+N+ Sbjct: 177 KESEYEAIASALKKRISDL--KVFNTICPATSDRQAALKKLAYEVDALLVIGGKNSANTK 234 Query: 230 RLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 RL + A K A+LI+DA +I +E +G+TAGAS PD ++ V +L + Sbjct: 235 RLFQTAVDTKKPAWLIEDASEIPKEIFS-YSVIGLTAGASTPDFIIDEVEKKLLE 288 >UniRef50_C8PSH0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PSH0_9SPIO Length = 333 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 90/290 (31%), Positives = 134/290 (46%), Gaps = 10/290 (3%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 + A G+C GV RA+ V ALA Y +Y ++HN + L +G + Sbjct: 48 VKRAQVLGYCMGVRRAVDAVYRALADYPDKTVYTYGPLIHNPVTMRLLEAKGVHIVNPDE 107 Query: 62 EVPDGAILIF----SAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+ I AHG+S R E + DATCP V + A+ S++G I Sbjct: 108 ELKPQIIPQSPIIIRAHGISPQKRQELIDCGAIIIDATCPKVIASQFKAAQYSQKGYTVI 167 Query: 118 LIGHAGHPEVEGTMGQY-SNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSD 176 L G H E+ G G S P G V++ + L + + QTT+ D+ Sbjct: 168 LAGDRNHGELIGIRGYVLSVPNGKCITVQTAAEAETLQ-DDGAPTVLIAQTTIKRDEYRA 226 Query: 177 VIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQ 236 + D L K+ + + IC AT RQEA+ L ++ + +LVVG NS+N+ RL + A Sbjct: 227 IADILHKKIAHLT--VLETICSATDERQEALLELVKEVDAILVVGGSNSANTRRLLQTAV 284 Query: 237 RMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 GK A+L + A DI E V +G+ AGAS PD + + + L +L Sbjct: 285 DSGKPAWLAETAADIPSE-VCCYHTIGLAAGASTPDSSIDTIESILDKLP 333 >UniRef50_D1AGH3 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AGH3_SEBTE Length = 291 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 85/290 (29%), Positives = 154/290 (53%), Gaps = 12/290 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 +I+ A GFC GV A+ V + + IYV +VHN +V++ L ++G IF+ + Sbjct: 6 EIIRAEHMGFCFGVREAVDEVHRYVDMNRGQIYVLGMLVHNEFVIEKLLKKGVIFVSEED 65 Query: 62 EVPD------GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + + G I+I AHG +Q V+ + + + D C V +V +RG + Sbjct: 66 VLNNNTPLKSGDIVIIRAHGTTQNVQKKLLEIGVKLIDMACIYVKSARDQVVIWEQRGYK 125 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 S+ IG HPEV+G P + S D++ + + EK F+ QTT + Sbjct: 126 SVFIGDKDHPEVKGITSYGIKP----LIFGSLDELKQAELDINEKWVFLFQTTYNRFIFQ 181 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 ++ D + RF I IC AT RQ A+ LA++ + V ++GS+ SSN+ +L +++ Sbjct: 182 EINDYIINRF--INYKVVKTICGATHQRQSAIEKLAQEVDAVFIIGSEQSSNTKKLYQIS 239 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + + ++++LI++ DI++ + V+ +GV+AGAS P+ L+ + ++++L Sbjct: 240 KNLNEKSYLIENNDDIKKHMLDGVRKLGVSAGASTPEELIAIIENKIKEL 289 >UniRef50_C1MT01 Predicted protein n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MT01_9CHLO Length = 523 Score = 293 bits (751), Expect = 6e-78, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 147/338 (43%), Gaps = 56/338 (16%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 + LA+ GFC GV+RA+ + A Y A +++ +E++HN V L + G FIE+ Sbjct: 174 LKLADAYGFCWGVERAVQMAYEARKQYPDAKLWITNEIIHNPTVNKRLGDMGVNFIEETK 233 Query: 62 E------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + V +G ++I A G S + ++ D TCP V+KV V +R+ Sbjct: 234 DGKDFSGVGNGEVVILPAFGASVHEMKLLAEKGASIVDTTCPWVSKVWNAVDAHTRKEFT 293 Query: 116 SILIGHAGHPEVEGTMGQYS------NPEGGMYLVE---SPDDVWKL------------- 153 SI+ G H E T + + YL + + D + Sbjct: 294 SIIHGKWAHEETVATASFAGTYLVIKDMKEATYLCDYILNGGDKEEFMAKFVNAHSEGFD 353 Query: 154 TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATTNRQE 205 + + L QTT+ +T + L + + G D IC AT RQ+ Sbjct: 354 PDVDLDGLGIANQTTMLKGETQAIGKLLERTMMEKHGVANLADHYMVMDTICDATQERQD 413 Query: 206 AVRALAE-QAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQE----------- 253 A+ L E + +++LVVG NSSN+ L E+++ +F +D + + E Sbjct: 414 AMYQLVEDKPDMMLVVGGYNSSNTQHLQEISEDASVPSFWVDTPERLDEDNVIAHRLAHG 473 Query: 254 ------EWVKEVK-CVGVTAGASAPDILVQNVVARLQQ 284 +W+ E +GVT+GAS PD +V++VV + + Sbjct: 474 ELVETKDWLPEGDVVIGVTSGASTPDKVVEDVVDMIFK 511 >UniRef50_A8RBC4 Putative uncharacterized protein n=3 Tax=Erysipelotrichaceae RepID=A8RBC4_9FIRM Length = 303 Score = 292 bits (749), Expect = 8e-78, Method: Composition-based stats. Identities = 108/308 (35%), Positives = 161/308 (52%), Gaps = 19/308 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAISI + Y IYV +VHNRYV+ +L+ ++ Sbjct: 1 MEIIKVVPRGYCKGVTRAISIAKETAQKYPDKSIYVLGMLVHNRYVMQALKALNIHAVDD 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + E+P I+IF+AHG++ V +AK L DA+CP V K V Sbjct: 61 PHKSRLQLLDELPKDCIVIFTAHGIAPQVIEKAKQMGLICIDASCPDVVKTQQLVYEKLN 120 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 G + IG HPE E + ++L+ S +D+ +T N + QTT+S+ Sbjct: 121 EGYDVFYIGKRSHPEAEAVLS----LSSHVHLITSKEDIDTIT--NVTNVFVTNQTTMSI 174 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQA-EVVLVVGSKNSSNSNR 230 DT + + +++++P V ++IC AT RQEAV L QA +V+ VVG K+S+NSNR Sbjct: 175 FDTQALFNYIKQKYPNAV--LCEEICNATRIRQEAVANLKNQAIDVLYVVGDKHSNNSNR 232 Query: 231 LAELAQRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 LA++AQ +LIDD DI+E + K +G+T+GAS P L V+ L+ + Sbjct: 233 LAQIAQENKIANVYLIDDVNDIEEAQFAKAKRIGITSGASTPTYLTSQVIHYLEGYEQNK 292 Query: 290 AIPLEGRE 297 P E Sbjct: 293 QKPCIEIE 300 >UniRef50_C5CIU9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPH_KOSOT Length = 298 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 144/300 (48%), Gaps = 17/300 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I+LA GFC GV+RA+ + L V ++VHN V+ L++ G + Sbjct: 1 MKIVLAESLGFCYGVNRAVEATKRLLKEK-RDARVIGDIVHNEIVMKKLKDMGLKVYPDL 59 Query: 61 SEVP-----DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + + ++ I AHG S V + K R V D TCP+V V ++G Sbjct: 60 SSIDFSDTAENSVAIIRAHGASPDVEDFLKRRFGYVVDLTCPIVYNVFSLAKDLEKKGYF 119 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK----LTVKNEEKLSFMTQTTLSV 171 ++ G H EV+ G+ ++ +VE D L K +K++ ++QTT++ Sbjct: 120 IVIFGKKDHAEVKALCGRLNDY----LIVEPGYDFETIKAFLREKKPKKVALISQTTMNS 175 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 + + + L + I + IC T NR++ LA+ + V+VVG K SSN+ +L Sbjct: 176 ESFEKLAEKLL-KLEGIEVSVNNTICNVTINREKMAIHLAQTCDAVVVVGGKRSSNTGKL 234 Query: 232 AELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 A++ + GKRAF + + + + + + + VG+ +G S P + ++ ++ GE I Sbjct: 235 AKIVESHGKRAFHVQNPEQLPD--LSIYRKVGIISGTSTPKEQILKILDYIKFTYEGEVI 292 >UniRef50_C7H149 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H149_9FIRM Length = 703 Score = 289 bits (740), Expect = 1e-76, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 146/305 (47%), Gaps = 9/305 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--EQ 59 +I+L GFC GV AI + A A I+ +++HN+ VV+ L ERG + ++ Sbjct: 12 KIILVEGSGFCFGVKNAIQKAKRARAELDKEIFTLGDIIHNKVVVEDLNERGITAVGEDE 71 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 I + G+ ++ +HG S+A +A D + DATCP V ++H V S +G I++ Sbjct: 72 IETLKRGSNIVVRSHGASRAFFEKAAGLDFNLIDATCPYVLRIHTLVKNESLKGRVIIIV 131 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVI 178 G+ HPEV G G + + ++ ++ K + K + + QTT+ + V Sbjct: 132 GNEEHPEVAGISGWCCGEKAVISENSKKSEIEEICEKYKGKEMVVVGQTTIKQEAYERVC 191 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + ++ D +C TT RQE A+ + ++V+G SSNS +L E+ + Sbjct: 192 EVIKSVNDHAE--VMDTLCSITTTRQEKAFECAKNVDAMIVIGDSKSSNSLKLYEICSSV 249 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG----GGEAIPLE 294 K F I++ D+ + + +GV A ASAP +++ V+ + + G E + L Sbjct: 250 NKNTFFIENKSDLPLKKLSNCTTIGVVASASAPGQIIREVMVIMNENQNETTGNEMLELM 309 Query: 295 GREEN 299 E Sbjct: 310 DEIEK 314 >UniRef50_B0C4N8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=5 Tax=Cyanobacteria RepID=ISPH_ACAM1 Length = 415 Score = 288 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 80/363 (22%), Positives = 140/363 (38%), Gaps = 73/363 (20%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFI---- 57 I LA GFC GV+RAI++ + I++ +E++HN V +LR+ FI Sbjct: 57 IHLAEAFGFCWGVERAIALAYETRRQFPQERIWITNEIIHNPSVNKNLRDMKVEFIPVQP 116 Query: 58 ---EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE 114 + + V ++I A G S + T+ D TCP V+KV V + + Sbjct: 117 DGQKDFTVVGQNDVVILPAFGASVQEMQLLHDKGCTIMDTTCPWVSKVWTSVEKHKKGSY 176 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--------------------- 153 SI+ G H E T G ++ + ++ + Sbjct: 177 TSIIHGKYKHEETIATSSFA----GTYLVLLNLEEAEYVADYILNPGDTPSEREQRRADF 232 Query: 154 -------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR-------- 192 + E++ QTT+ +T + + + GP Sbjct: 233 MAKFANAHSPGFDPETDLERVGIANQTTMLKGETEQIGKLFERTVMRKYGPAQVNEHFLS 292 Query: 193 KDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI 251 + IC AT RQ+A+ L ++ ++++V+G NSSN+ L E++ ++ ID I Sbjct: 293 FNTICDATQERQDAIFQLVDEPLDLMVVIGGFNSSNTTHLQEISIDKNIPSYHIDSVDRI 352 Query: 252 QE-----------------EWVK-EVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 W+ +GVT+GAS PD +V ++V ++ + A + Sbjct: 353 GPGNRVEHKPLNADLTVTDNWLPNGPLAIGVTSGASTPDKVVSDIVEKIFSIKSASAEVV 412 Query: 294 EGR 296 R Sbjct: 413 GVR 415 >UniRef50_A8JEV9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Chlamydomonas reinhardtii RepID=A8JEV9_CHLRE Length = 465 Score = 288 bits (738), Expect = 2e-76, Method: Composition-based stats. Identities = 85/351 (24%), Positives = 144/351 (41%), Gaps = 67/351 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENA-LAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA G+C GV+RA+ + A LA ++V +E++HN V L+E +E Sbjct: 101 VKLAKAYGYCWGVERAVRMAYEARLAHPDKKVFVTNEIIHNPEVNSRLKEMNIEIVEDEG 160 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 S + G ++IF A G + + K + + + D TCP V KV V +R+ Sbjct: 161 KGKDYSMIGGGDVVIFPAFGATVQELTDFKEKGVQMVDTTCPWVAKVWNSVDTHTRKQYT 220 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------- 153 S++ G H E T SN +V+ + + Sbjct: 221 SVIHGKYSHEETIATASFASNY----IIVKDLKEAQYVCDYILQGGNREEFLQKFSKAVS 276 Query: 154 ----TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDICYATT 201 +++ QTT+ +T + L K GP + IC AT Sbjct: 277 AGFDPETMLDRVGLANQTTMLKGETEQIGKMLEKTMLTKYGPAKLNDHFLLMETICDATQ 336 Query: 202 NRQEAVRALA--EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEE----- 254 RQ+A+ + + ++++VVG NSSN++ L E+A+ G +F +D A I E Sbjct: 337 ERQDALYEMVADPEIDMMIVVGGFNSSNTSHLQEIAEHKGLASFWVDSAARIDVEKNVIL 396 Query: 255 -------------WVKEVK--CVGVTAGASAPDILVQNVVARLQQLGGGEA 290 W+ K +G+T+GAS PD V+ V+ ++ ++ Sbjct: 397 HKLAHGELKETTGWLNPGKPVTIGITSGASTPDRAVEEVLHKVFKIYNPNF 447 >UniRef50_C3RLQ9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Bacteria RepID=C3RLQ9_9MOLU Length = 303 Score = 287 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 91/301 (30%), Positives = 152/301 (50%), Gaps = 19/301 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M++ PRG+C GV RAI + + +Y+ +VHN+Y+VD+L G I++ Sbjct: 1 MKVYPITPRGYCKGVVRAIELAKKQAHQDD--VYILGMIVHNQYIVDALNNLGVKTIDKK 58 Query: 60 -------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + +V G +I +AHG S V +A S+++ V +ATCP V K H + + Sbjct: 59 GASREELLDQVSQG-TVIITAHGASHNVIKKAHSKNIQVINATCPDVIKTHDLIKNYLNQ 117 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G E + IG AGHPE EG + ++L+E+ D L QTT+S+ Sbjct: 118 GIEILYIGKAGHPESEGALS---IDPAHIHLIENKTDFENL--DPNLNYVITNQTTMSLY 172 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D D+ + + + ++ K+ C ATT RQEA+ + ++ +V+ +VG +S+N+ +LA Sbjct: 173 DVYDLCEYAKTKLNNLIV-AKET-CQATTVRQEAIAKINDEVDVIFIVGDPHSNNTKKLA 230 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +A ++ K ++I+ DI +KE V++GAS P L V+ L+Q Sbjct: 231 SIAHEKANKDTYMIESVNDIDISMLKEKHAAAVSSGASTPTYLTNQVIEYLRQFDYQNVS 290 Query: 292 P 292 Sbjct: 291 T 291 >UniRef50_A5GWG3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=115 Tax=cellular organisms RepID=ISPH_SYNR3 Length = 406 Score = 286 bits (733), Expect = 7e-76, Method: Composition-based stats. Identities = 86/352 (24%), Positives = 141/352 (40%), Gaps = 64/352 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIF----- 56 I LA GFC GV+RA++I Y I++ +E++HN V L E +F Sbjct: 57 IRLAEAFGFCWGVERAVAIAYETRRHYPTERIWITNEIIHNPSVNAHLVEMNVLFIPVEE 116 Query: 57 -IEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 ++ S V G ++I A G + R + D TCP V+KV V R + Sbjct: 117 GVKDFSGVESGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWNSVERHKKNSFT 176 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------- 153 S++ G H E T G +V ++ + Sbjct: 177 SVIHGKVKHEETLATSSFA----GTYLVVLDLEEAQLVCDYILGNGNREAFLKRFAGATS 232 Query: 154 ----TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDICYATT 201 ++ ++ QTT+ +T D+ + + GP + IC AT Sbjct: 233 PGFDPDRDLSRIGVANQTTMLKSETEDIGRLFERTLLRRYGPTDLNDHFLAFNTICDATQ 292 Query: 202 NRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI--------- 251 RQ+A+ +L ++ ++++V+G NSSN+ L E+A G + ID + I Sbjct: 293 ERQDAMFSLVDEPLDLMVVIGGYNSSNTTHLQEIAVSRGIPSVHIDAPERIGPGNAVEHK 352 Query: 252 ---------QEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE 294 + + +G+T+GAS PD +V+ V+ RL QL I E Sbjct: 353 PLGQDLERLEPFLPEGDLRIGITSGASTPDRVVEGVIDRLLQLAEAGQIAAE 404 >UniRef50_A6LIB3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=4 Tax=Bacteroidales RepID=ISPH_PARD8 Length = 290 Score = 283 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 136/295 (46%), Gaps = 14/295 (4%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE--Q 59 ++ + GFC GV AI E L +Y ++VHN V+ L G I+ Sbjct: 3 EVEIDKDSGFCFGVVTAIESAERELGNTDT-LYCLGDIVHNSLEVERLEHMGLHTIDHEG 61 Query: 60 ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGE----E 115 +S + D ++ AHG + AK ++T+ DATCP+V ++ ++ + + + Sbjct: 62 LSRLRD-RKVLLRAHGEPPSTYALAKRNNITIIDATCPVVLRLQRKIHKCYQETRANNTQ 120 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 ++ G GH EV G +GQ EG ++E +D+ +L +S +QTT S+D Sbjct: 121 LVIYGKKGHAEVNGLVGQ---TEGTAIVIEKIEDLDRLDF--TRAISLFSQTTKSLDGFK 175 Query: 176 DVIDALRKRFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAEL 234 V+ +++R + + D IC NR ++A A + V V + SSN L E Sbjct: 176 AVVAEIKQRMAEGVEFNYYDTICRQVANRLPNIKAFASSHDWVYFVAGRKSSNGKMLFEE 235 Query: 235 AQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGE 289 ++ I + +I E + V+ VGV S P L++ V R+++L E Sbjct: 236 CRKANPNTLFISEVSEITEPLPEGVRRVGVCGATSTPKWLMEEVAVRIKELNASE 290 >UniRef50_Q1MQE5 Ribosomal protein S1 n=1 Tax=Lawsonia intracellularis PHE/MN1-00 RepID=Q1MQE5_LAWIP Length = 294 Score = 283 bits (725), Expect = 5e-75, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 129/289 (44%), Gaps = 9/289 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGA---PIYVRHEVVHNRYVVDSLRERGAIFI 57 MQ++ A G C GVD A+ + ++ + ++HN V+ + +G I + Sbjct: 9 MQVIRAKTAGTCWGVDLALRKLSQSIENKEKANTRFVMYGLIIHNPQVIVEYKAQGVICV 68 Query: 58 EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 + I EV G +I AHG+ + + + DATCP V K + +A A+ + Sbjct: 69 DSIEEVRAGDTVIIRAHGIPIYEEQQLTDIGINLIDATCPKVKKTQLAIANATNSETILL 128 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 L G A HPEV+G + P ++ ++ V + + +QTT ++ Sbjct: 129 LFGEANHPEVKGLISYSQGP---FHVFDTKQFVEDFDNSQNKTIVLASQTTQDEITFKEI 185 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 + L ++ I + IC AT RQ + ++ EQ ++VVG S N+ RL EL++ Sbjct: 186 QEILHQK--GIQPVILNTICDATYKRQRELLSITEQVNTMVVVGGFTSGNTRRLVELSKA 243 Query: 238 MGKRAFLIDDAKDIQE-EWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 G + F I+ + + + +G+T GAS P L+ V L Sbjct: 244 KGIKTFHIETVDALYGNNELDQNDIIGLTGGASTPKQLIDKVEDFLSNN 292 >UniRef50_B1LBI2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Thermotogaceae RepID=ISPH_THESQ Length = 275 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 86/288 (29%), Positives = 147/288 (51%), Gaps = 20/288 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VE L G + E+VHN+ V++ L ++G Sbjct: 1 MKIVVAKNIGFCFGVERAIRTVEELLDE-GKKVVTDGEIVHNKQVMEQLTKKGLKVS--- 56 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 SE+ DG + + AHG+ + E K V D TCP+V+++ R ++ + I+ G Sbjct: 57 SEMTDGEVFVVRAHGIPKDRLEELKKIFPEVVDLTCPIVSQLFKTAQRYAKE-RKVIVFG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVK-NEEKLSFMTQTTLSVDDTSDVID 179 HPE+ G V K+ K E+K+ F++QTT S+++ + + Sbjct: 116 KEDHPEMVALRGYAPAI------------VTKVPFKFEEKKVVFLSQTTSSLEEYKEFVA 163 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 A+ + + IC T NR+ V L++ ++ +VVG K+SSN+ +L +A + Sbjct: 164 AMIRMNEFEEAVFLNTICPVTVNREREVEELSKICDLSIVVGGKHSSNTGKLFRIASKHS 223 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 K I+ ++ + VK V V +G S P+ L++NVV +L+++ G Sbjct: 224 K-TIWIESPDELPADVVK-YGTVCVFSGTSTPNSLIENVVRKLKEMEG 269 >UniRef50_Q8EWR9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Mycoplasma penetrans RepID=ISPH_MYCPE Length = 299 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 153/301 (50%), Gaps = 20/301 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRGFC GV A + + +Y Y+ +VHN+ ++ L E G + Sbjct: 1 MKIIKITPRGFCKGVVDAYATCKKIAKLYPNHEKYLIGWLVHNKEIIKELEELGIQTKDD 60 Query: 60 -------------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 I + + I+IFSAHG Q ++A+ + L VFD TC VTK H + Sbjct: 61 KNHSRSEIIDSIEIKDKNNPPIVIFSAHGTDQKTIDKAREKGLVVFDTTCIYVTKTHDLI 120 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQ 166 +G + IG HPE T+ + + L+E+ +D+ + ++E+ + Q Sbjct: 121 KEKIEQGYQIFYIGVNNHPETISTLS----IDKSIILIETVNDIENIRTESEKPIFVTNQ 176 Query: 167 TTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSS 226 TT+S+ + ++ + L+ ++ I +DIC A +RQ+AV + + +++LVVG S+ Sbjct: 177 TTISIYEFEEITETLKSKYKNIEFK--NDICNAAKDRQDAVINMPSEVDLLLVVGDIKSN 234 Query: 227 NSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 NS +L E+ + + LI + K+I++EW KC+ +T+G S P L V+ L++ Sbjct: 235 NSKKLVEIGIKKQIESHLIWNTKNIKDEWFINKKCLAITSGCSTPTWLANYVIIFLEKKL 294 Query: 287 G 287 G Sbjct: 295 G 295 >UniRef50_B3QQE0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=12 Tax=Chlorobiaceae RepID=ISPH_CHLP8 Length = 332 Score = 281 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 79/328 (24%), Positives = 129/328 (39%), Gaps = 41/328 (12%) Query: 1 MQILLANPR-GFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIE- 58 M+I L GFC GV I + E L G +Y +VVHN V L G I+ Sbjct: 1 MKINLDRTSSGFCIGVQGTIHVAEEKLNQSGE-LYCLGDVVHNEVEVKRLEALGMETIDI 59 Query: 59 -QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 E+ D ++ AHG + A+ +L + D TCP+V K+ + G + I Sbjct: 60 PAFEELRDAE-VLIRAHGEPPSTYETARRNNLAITDTTCPVVAKLQKTAKMLHQLGYQVI 118 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G HPEV G GQ ++ + + D+ + K + ++QTT+ V ++ Sbjct: 119 IYGKKIHPEVIGINGQCNDEGVVIKHPDLSDEAEIAPLDLGRKTALISQTTMDVPGFYEL 178 Query: 178 IDALRKRFPKIVGP-------------------------------RKDDICYATTNRQEA 206 L K F + KD IC ++R Sbjct: 179 KKNLEKLFAEHGHRNPGTKSGEWMAVRDIDITSEKTGGRAMPELVYKDTICRQVSSRNGK 238 Query: 207 VRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWV-----KEVKC 261 +R A + ++ + SSN L + + ++ I+D +IQ EW K V+ Sbjct: 239 LRDFALANDCIVFAAGRKSSNGQVLYSICKDANPHSYFIEDVDEIQPEWFVGENGKPVES 298 Query: 262 VGVTAGASAPDILVQNVVARLQQLGGGE 289 VG+ S P L++ V + + G + Sbjct: 299 VGICGATSTPMWLLEKVANYIGKTFGDD 326 >UniRef50_D1Y0F8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Prevotella RepID=D1Y0F8_9BACT Length = 304 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 127/304 (41%), Gaps = 28/304 (9%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +QI + + GFC GV AI E LA G +Y ++VHN V+ L G + I+ Sbjct: 2 LQIEIDSGSGFCFGVTTAIKKAEEELAK-GTKLYCLGDIVHNSMEVERLETNGLVTIDHE 60 Query: 61 SEVP-DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR------- 112 ++ AHG AK ++ + DATCP+V + + + Sbjct: 61 QMKKLHNVKVLLRAHGEPPETYELAKRNNIEIIDATCPVVLALQRRIKKQYESKLDDKLE 120 Query: 113 -------------GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEE 159 G + ++ G GH EV G +GQ + ++E +DV KL + Sbjct: 121 DKQMEFVPESTSVGSQIVIFGKNGHAEVLGLVGQ---TKSEALIIEKFEDVKKLNF--TK 175 Query: 160 KLSFMTQTTLSVDDTSDVIDALRKRF-PKIVGPRKDDICYATTNRQEAVRALAEQAEVVL 218 + +QTT S+++ +I+ ++ P D IC NR + A + +V++ Sbjct: 176 DIYLYSQTTKSLNEFHQIIEYIQSHIDPSAKFQSFDTICRQVANRMPNISTFATRHDVII 235 Query: 219 VVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNV 278 V K SSN L + R++ ++ A +I W + V VG+ S P L++ Sbjct: 236 FVAGKKSSNGKVLFHECLDVNPRSYQVECADEIDMSWFEGVNTVGICGATSTPKWLMEEC 295 Query: 279 VARL 282 + Sbjct: 296 RDEI 299 >UniRef50_B9K8E2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=ISPH_THENN Length = 279 Score = 280 bits (717), Expect = 5e-74, Method: Composition-based stats. Identities = 92/288 (31%), Positives = 144/288 (50%), Gaps = 20/288 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I++A GFC GV+RAI VEN L G + E+VHNR V++ L ++G Sbjct: 1 MKIIVAKNVGFCFGVERAIRTVENLLNE-GKRVVTDGEIVHNRQVMEDLLKKGLKISSDP 59 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 DG + + AHG+ + + + V D TCP+V ++ S RG + I+ G Sbjct: 60 ---TDGDVFVVRAHGIPEEKLEKLRKIYPEVVDLTCPIVFQLFRTAREYSSRG-KLIVFG 115 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK-LSFMTQTTLSVDDTSDVID 179 HPE+ MG V K K EEK + F++QTT S+D+ + + Sbjct: 116 KRDHPEMVALMGYAPAI------------VTKKPFKTEEKNVVFLSQTTSSLDEYREFVS 163 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + K + IC T R+ V+ L++ ++ +VVG K+SSN+ +L LA R Sbjct: 164 EMIKMNNFEKAIYLNTICPVTVEREREVKELSKICDLSVVVGGKHSSNTGKLFRLASR-N 222 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGG 287 RA ++ +I E+ VK V V +G S P L++NVV +L+++ G Sbjct: 223 SRAIWVESPDEIPEDVVK-YGTVCVFSGTSTPVSLIENVVRKLEEMEG 269 >UniRef50_C0JZX4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium URE4 RepID=C0JZX4_9BACT Length = 288 Score = 280 bits (716), Expect = 6e-74, Method: Composition-based stats. Identities = 84/293 (28%), Positives = 138/293 (47%), Gaps = 14/293 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 +++ + + GFC GV RAIS E L +Y +VHN +D L G + I Sbjct: 2 VKVEIDSRSGFCGGVIRAISQAERFLQESD-HLYSLGAIVHNEAELDRLGAEGLRTVASI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVA----RASRRGE-- 114 +VP+G ++ AHG + +A+ R L V D TCP+V K+ + R G Sbjct: 61 PDVPEGETVLIRAHGEPPSTYADARRRGLVVIDCTCPVVLKLQEHIREAYARLHADGLHG 120 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTTLSVD 172 ++ G GH EV G +GQ +G +VE+ + + + + +QTT S Sbjct: 121 TLLIFGKIGHAEVLGLLGQV---DGDAIVVENRAMLEDALPAIDFSQPVEIFSQTTKSPA 177 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 + +++ D +R ++ D IC NR E + A A +++L V ++SSN L Sbjct: 178 EYAEICDRVRSLGDRVT--VHDTICAQVANRHEHLAAFARAHDLILFVAGESSSNGRVLF 235 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 +L R+ R++ I DI WV++ VGV S P L++ V +++L Sbjct: 236 DLCHRLNPRSYRIGAPADIDPAWVRDGDHVGVCGATSTPQWLLEMVAEAVREL 288 >UniRef50_B6YQB8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Bacteroidales RepID=ISPH_AZOPC Length = 287 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 80/294 (27%), Positives = 133/294 (45%), Gaps = 15/294 (5%) Query: 1 MQ-ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+ I + GFC GV AI E L +Y ++VHN V L+++G I Sbjct: 1 MKTIEIDCDSGFCFGVMSAIQRAEKELITNDE-LYCLGDIVHNSQEVVRLQKKGLKIINH 59 Query: 60 ISEVPD--GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVAR----ASRRG 113 E+ ++F AHG + A + + DATCP+V ++ ++ + + Sbjct: 60 -EELGRIYNKKVLFRAHGEPPSTYEVANQNSIHIIDATCPVVLQLQKKIQKIYQSFANTK 118 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 + +L G + H EV +GQ G ++ES +D+ ++ + + +QTT+ VDD Sbjct: 119 SQIVLFGRSKHAEVSALVGQ---TNGNAIVIESKNDIQQIDF--AKNIYLFSQTTMFVDD 173 Query: 174 TSDVIDALRKRFPK-IVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 +++ + + I+ + IC+ NR +R A Q ++L V NSSN L Sbjct: 174 FKEIVKEIENKIIHPIIFSSFNTICHQMVNRINHIRKFAVQHNLLLFVAGDNSSNGTILF 233 Query: 233 ELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLG 286 +R +LI D KDIQ EW +K VG+ S P L++ + L Sbjct: 234 NECRRANLNTYLISDEKDIQSEWFNGIKSVGICGATSTPKWLMEKIALSLIPFH 287 >UniRef50_UPI000196B3D1 hypothetical protein CATMIT_01295 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196B3D1 Length = 324 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 96/302 (31%), Positives = 161/302 (53%), Gaps = 19/302 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M++ PRG+C GV RAI+IV+ + G PI V +VHN+++VD+L++RGAI IE Sbjct: 22 MKVTGIVPRGYCKGVIRAINIVKETIEQPG-PITVLGMIVHNQFIVDALKKRGAITIEDA 80 Query: 60 -------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + E+ +G +I +AHG V +AKS+ L V DATC V K H + +R Sbjct: 81 SKTRMELLDEINEG-TVIITAHGAGDCVIEKAKSKGLNVVDATCLDVIKTHTLIKEQLKR 139 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVD 172 G++ + IG HPE EG + ++L+ S D+ L ++ QTT+S+ Sbjct: 140 GKDVLYIGKKNHPEAEGAL---LIDPEHIHLITSKKDLETL--DKDKHYVMTNQTTMSLY 194 Query: 173 DTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLA 232 D D+ + ++ + + C AT RQEA+ + E ++V++VG +S+N+ +LA Sbjct: 195 DVYDLCEYAKEI---LDVEIMKETCSATQIRQEAIAKMDEDIDLVIIVGDPHSNNTKKLA 251 Query: 233 ELA-QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 ++ ++ K +I +++ W+K K VGV++GAS P +L ++ L+Q Sbjct: 252 SISMEKAHKDTKMIGSLEELDLSWLKGKKHVGVSSGASTPTVLTNQIIDFLKQYDENNPD 311 Query: 292 PL 293 Sbjct: 312 SF 313 >UniRef50_C5VII4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Prevotella RepID=C5VII4_9BACT Length = 335 Score = 278 bits (712), Expect = 2e-73, Method: Composition-based stats. Identities = 79/336 (23%), Positives = 132/336 (39%), Gaps = 61/336 (18%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFI--E 58 +QI + N GFC GV AI E LA G +Y ++VHN V+ L ++G I I E Sbjct: 2 LQIEIDNGSGFCFGVTTAIKKAEEELAK-GTKLYCLGDIVHNSMEVERLTKKGLITINHE 60 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE--- 115 Q+ E+ + ++ AHG A+ ++ + DATCP+V + + +G + Sbjct: 61 QMRELHN-VKVLLRAHGEPPETYELARRNNIEIIDATCPVVLALQRRIKTQYEKGRQPSY 119 Query: 116 ------------------------------------------------SILIGHAGHPEV 127 ++ G GH EV Sbjct: 120 MISSKGGAAVDEPSSLKPVTNEAVETSISSVSLPPAVGEGQELSASSSIVIFGKNGHAEV 179 Query: 128 EGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRF-P 186 G +GQ ++E +DV L N+ + +QTT S+D+ +I+ ++ P Sbjct: 180 LGLVGQ---THSQAIVIEKFEDVKALDFNND--IYLYSQTTKSLDEFHKIIEYIQSHISP 234 Query: 187 KIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLID 246 K D IC NR + A + +++L V + SSN L + + ++ Sbjct: 235 KAKFQSFDTICRQVANRMPNISTFAARHDLILFVAGRKSSNGKVLFHECLSVNPNSHQVE 294 Query: 247 DAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 A +I W V+ VG+ S P L++ + Sbjct: 295 SADEIDMSWFDGVETVGICGATSTPKWLMEECRDEI 330 >UniRef50_Q11YY5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=30 Tax=Bacteroidetes RepID=ISPH_CYTH3 Length = 293 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 142/298 (47%), Gaps = 21/298 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M +++ G+C GV+ AI + E+ +A G P++ ++VHN V+ L ++G I++ Sbjct: 1 MDVIIDKNSGYCFGVEFAIQMAEDEMAT-GEPLFCLGDIVHNSMEVERLAKKGLKIIDR- 58 Query: 61 SEVPD--GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA-----SRRG 113 E+ ++ AHG A ++ + DA+CP+V K+ V + S+ G Sbjct: 59 EELKKLSDCKVLIRAHGEPPETYQLALENNIELVDASCPVVLKLQNRVKASFDAIDSKDG 118 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDD 173 + ++ G GH EV G GQ + ++ + D+ K+ E+ ++ +QTT S Sbjct: 119 -QIVIYGQEGHAEVIGIAGQTGD---KAIVITTEKDLDKIDF--EKPVTLYSQTTKSTQG 172 Query: 174 TSDVIDALRKRFPKI------VGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSN 227 + D + R + D IC +NR+ +R +++ +VV+ V K SSN Sbjct: 173 FYKMKDLIEARVAEAGKNVDENFEYNDSICRQVSNREPQLRKFSKEFDVVIFVSGKKSSN 232 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 L + ++ +R++ +++ +I+ W++ VG+ S P L++ V +Q Sbjct: 233 GKALYGVCKQENERSYFVENETEIEPSWIRATDNVGICGATSTPMWLMEKVQNYIQAH 290 >UniRef50_B8C2Y3 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8C2Y3_THAPS Length = 462 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 89/361 (24%), Positives = 155/361 (42%), Gaps = 73/361 (20%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A+ + G +++ +E++HN V D L + FIE+ Sbjct: 105 VKVYLAKDFGFCWGVERSIALAYEAVEHFPGKTVHITNELIHNPEVNDKLHDMNVQFIEK 164 Query: 60 ISE-------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + E + +G ++I A G S ++++ V D TCP V+KV V + R+ Sbjct: 165 LGEGKKDFSKIGEGDVVILPAFGASFEEMTLMNNKNVEVVDTTCPWVSKVWNTVDQHQRK 224 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL------------------- 153 G S++ G GH E T+ + V+ + + Sbjct: 225 GLTSVIHGKYGHEETVATVSFCEDY----ICVKDIKEAEMVADYIINGGDKEKFLKYFEK 280 Query: 154 -------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDICY 198 +K+ QTT+ +T + ++K K GP D IC Sbjct: 281 AVSKGFDPDTMLDKVGLANQTTMYKKETRAIGQLMQKAMMKKFGPVNAKDHYLEFDTICD 340 Query: 199 ATTNRQEAVRALAEQA-----EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK---- 249 AT RQ+A+ L E + + +LVVG +SSN+ L E+ ++ G R+F I+ ++ Sbjct: 341 ATQERQDAISDLVENSDELGLDFILVVGGWDSSNTAHLLEIPEKAGVRSFHINKSECIGA 400 Query: 250 -----------DIQEEWV-------KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAI 291 +I E + +GVT+GAS PD VQ+ + ++ L + Sbjct: 401 DNTITHRTVDGEIVTEKFIEDIENKDKKLVMGVTSGASTPDKAVQDSLDQIFMLKKVYSK 460 Query: 292 P 292 Sbjct: 461 E 461 >UniRef50_B7FUL0 Hydroxymethylbutenyl diphosphate reductase n=2 Tax=Phaeodactylum tricornutum RepID=B7FUL0_PHATR Length = 458 Score = 276 bits (707), Expect = 6e-73, Method: Composition-based stats. Identities = 90/359 (25%), Positives = 155/359 (43%), Gaps = 72/359 (20%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 +++ LA GFC GV+R+I++ A + +++ +E++HN V ++L+ + FIE+ Sbjct: 103 VKVYLAKDFGFCWGVERSIALAYEAAEHFPDRKLHITNELIHNPEVNENLKAKNVQFIEK 162 Query: 60 ISE-------VPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 + + V DG ++I A G S + +++ + D TCP V+KV V + ++ Sbjct: 163 LGDGTKNFASVQDGDVVILPAFGASFEEMDYFDKKNVEIVDTTCPWVSKVWNTVDKHQKQ 222 Query: 113 GEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL------------------- 153 G S++ G H E T + V++ + + Sbjct: 223 GLTSVIHGKYAHEETVATTSFCEDF----ICVKNFKEAEMVANYILNGGDKDAFMKHFEN 278 Query: 154 -------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPR--------KDDICY 198 K+ EK+ QTT+ +T + +K K GP D IC Sbjct: 279 AVSEGFDPDKHLEKVGLANQTTMYKKETRAIGQLFQKTMMKKFGPVKSKEHYMEFDTICD 338 Query: 199 ATTNRQEAVRALAEQA-----EVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAK---- 249 AT RQ+A+ + E A + +LV+G +SSN+ L E+ G RAF I+ A+ Sbjct: 339 ATQERQDAIHDMVESAQKDGLDFILVIGGWDSSNTAHLLEIPVHAGIRAFHINRAECIGA 398 Query: 250 ----------------DIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 + E+ KEV +GVT+GAS PD VQ+ ++++ L Sbjct: 399 DNTITHRTVDGEIVTTQLLEDMDKEV-VMGVTSGASTPDAAVQDSLSQIFLLKKMYDES 456 >UniRef50_A9BGS3 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPH_PETMO Length = 284 Score = 274 bits (702), Expect = 3e-72, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 149/287 (51%), Gaps = 12/287 (4%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I +A GFC+GV + + V+N+L IY+ E+VHNR V++ L GAI I + Sbjct: 1 MEINVAKRTGFCSGVQKTYNEVKNSLVDKNK-IYIYGELVHNRKVIEELNSAGAITITGM 59 Query: 61 SEVPDGA---ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESI 117 ++PD + LI AHG+S+A ++ K R V D TCP+VT + V + + G + Sbjct: 60 DDIPDDSIDETLIIRAHGISKAEKDLLKKRFSKVIDMTCPIVTNLVKYVEKKQKDGFFVV 119 Query: 118 LIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDV 177 + G HPE+ G G + + L ++K+ ++QTT+ ++ + Sbjct: 120 VYGKPDHPEILGLKGNVDESKLLITL--------SPVTIPQKKVLIVSQTTMGEEEYKNF 171 Query: 178 IDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQR 237 I ++ +D IC T R++ L++++ ++LV+G KNSSN+ +L ++++ Sbjct: 172 ITSILTINSFTEVLIRDTICSETILREKETLELSQKSTLMLVLGGKNSSNTQKLYRISKK 231 Query: 238 MGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 KR + I+ ++++E + +G+ G+S P + V+ L Q Sbjct: 232 YCKRTYHIESGEELKEITISPQDKIGIVTGSSTPTSELNKVLEYLSQ 278 >UniRef50_B2S3D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=3 Tax=Treponema RepID=ISPH_TREPS Length = 376 Score = 273 bits (700), Expect = 4e-72, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 134/322 (41%), Gaps = 41/322 (12%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS- 61 I A+ G+C GV A+ + E+A A + +Y +VHN + LR RG ++ Sbjct: 10 ITRAHTLGYCGGVRMAVRMAEHARAHHRGSVYTLGPLVHNPVTLARLRARGIECLDPAHL 69 Query: 62 -----------------EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHM 104 E ++ AHGV+ V + V DATCP V + Sbjct: 70 SFALHAPAAPGAAPHAVEEKTARTVVIRAHGVAPEVYEALERSGAQVVDATCPRVKESQR 129 Query: 105 EVARASRRGEESILIGHAGHPEVEGTMGQYSN------------------PEGGMYLVES 146 + +G IL G H E+ G G P+ ++V++ Sbjct: 130 RAQGFAAQGLHVILAGDRNHGEIVGIEGYVRAGAAQACSHLPGGAPDGMLPQVQCFVVQN 189 Query: 147 PDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEA 206 + L + + + QTT++ + + A R R ++ IC AT RQ A Sbjct: 190 AREAAALP--CLARAALLAQTTITQGEYDAIAAAARTRVRELT--VARTICAATARRQAA 245 Query: 207 VRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTA 266 +RALA E +LV+G +S+N+ RL A+ +L++ +DI + + VG++A Sbjct: 246 LRALAPTVEALLVIGGAHSANTQRLLHTARETSLPTWLVERVEDIPPD-IYAFSAVGISA 304 Query: 267 GASAPDILVQNVVARLQQLGGG 288 GAS PD ++ V L+ G Sbjct: 305 GASTPDCVIAAVEQALRTGGAP 326 >UniRef50_B4CZC4 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Verrucomicrobia RepID=B4CZC4_9BACT Length = 287 Score = 273 bits (699), Expect = 6e-72, Method: Composition-based stats. Identities = 85/286 (29%), Positives = 139/286 (48%), Gaps = 9/286 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+I LA G C GV AI+ E P+ + E+VHN V + L G Sbjct: 1 MKIQLAEHYGLCFGVRDAIAQAEELATR--GPLTILGELVHNPVVRERLARHGVREGALD 58 Query: 61 SEVPDGAI-LIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILI 119 + ++ +AHG S R E ++ V D TCPLV + H ++ +G ++I Sbjct: 59 DRDSAQSTQVMITAHGASDKARGEWRNAGFGVADGTCPLVLQAHEKLRALVEQGFVPVVI 118 Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G GH EV G G + + ++ES +D+ L +L ++QTT + ++D Sbjct: 119 GKRGHVEVNGLTGDFPD----ACIIESAEDLANLPT--AARLGVISQTTQPSEKVLALVD 172 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 A+R P D +C T NRQ A+R L E+ + ++VVG +NS+N+ +L A G Sbjct: 173 AIRIARPASEVRFCDTVCQPTKNRQSALRKLIEECDTLVVVGGRNSNNTLQLVAAATVAG 232 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + ++ A++++ +W + + VG+TAG S V V RL+ + Sbjct: 233 RAVHHVERAEELRPDWFRAARVVGITAGTSTLKETVATVRIRLEAI 278 >UniRef50_A8F7S0 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermotoga lettingae TMO RepID=ISPH_THELT Length = 278 Score = 272 bits (697), Expect = 9e-72, Method: Composition-based stats. Identities = 77/285 (27%), Positives = 149/285 (52%), Gaps = 15/285 (5%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQ- 59 M+I++A GFC+GV RA+ + + + IY E+VHN+ VVDSLR+RG +++ Sbjct: 1 MRIIVAEDIGFCSGVRRALKMTLSEINE-NEKIYTLGEIVHNKTVVDSLRKRGVNVLQEN 59 Query: 60 -ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESIL 118 I E + LI AHG+S+ E + + D TCP+V + +R + G ++ Sbjct: 60 IIPEDAKNSSLIIRAHGISRDQLFELQKVFKKIVDTTCPIVHNLFQTASRIHQEGYRIVV 119 Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 G HPE+ G + ++ P+ ++ M+QTT+S+D+ D + Sbjct: 120 FGKESHPEMSALKGYVKD---ATITLKPPE--------LSGRICIMSQTTMSIDEFYDFV 168 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 + + +C T R++ + +A+Q ++++++G KNSSN+++L ++A + Sbjct: 169 VKSISQSKFSEIRIINTVCEITARREKEAQKIAKQVDLMIIIGGKNSSNTSKLTKIASKF 228 Query: 239 GKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQ 283 RA I+ +++ + +V+ +G+T G S P+ V+ V+ +++ Sbjct: 229 -TRAIQIETPEEVDKINFDKVEMIGITTGTSTPEEDVKTVIDKIK 272 >UniRef50_B1Q2Q7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=2 Tax=Perkinsus RepID=B1Q2Q7_9ALVE Length = 575 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 92/390 (23%), Positives = 148/390 (37%), Gaps = 115/390 (29%) Query: 4 LLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI----- 57 LA GFC GV+RA++I + Y I++ +EV+HN V +L E G +I Sbjct: 177 KLAEAHGFCWGVERAVAIAYESSRRYPDKTIWMTNEVIHNPTVNRNLEELGIRYIPRDAG 236 Query: 58 --EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + S V G ++I A G + E K + +T+ D TCP V+KV V R + Sbjct: 237 NQKDFSVVSAGDVVILPAFGAAVKEMMELKRKGVTIVDTTCPWVSKVWSSVERHKKGEYT 296 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------------- 153 SI+ G + H E T ++++ D + Sbjct: 297 SIIHGKSKHEETIATSSFADKY----LILKNLKDAEYVCKFLLSKNKERLVDDFFEKFPA 352 Query: 154 --------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDIC 197 +K+ EK+ QTT+ +T+ + K ++ GP + IC Sbjct: 353 DRHSVGFDPLKDLEKVGVANQTTMLKGETALIAKLFEKTILQLYGPEGLNEHFVAFNTIC 412 Query: 198 YATTNRQEAVRAL-------------------------------AEQAEVVLVVGSKNSS 226 AT +RQ+A+ L A + +++LVVG NSS Sbjct: 413 DATQDRQDALYKLVGEKYEQPQSDMLEELGVDTPKTTDPQVTPTATKLDMMLVVGGFNSS 472 Query: 227 NSNRLAELAQRMG----KRAFLIDDAKDIQE---------------------------EW 255 N+ L E++ G RAF ID I E ++ Sbjct: 473 NTEHLQEISVEAGGVKDHRAFHIDGPARIDELRNTITHKPVETPPIEAARNHGLAVTHDF 532 Query: 256 VKEVK---CVGVTAGASAPDILVQNVVARL 282 + +GVT+GAS PD +++ + +L Sbjct: 533 LPGDGEHITIGVTSGASTPDDVLEQSLQKL 562 >UniRef50_D2MQD5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Bulleidia extructa W1219 RepID=D2MQD5_9FIRM Length = 300 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 22/294 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+I+ PRG+C GV RAI + + Y + + +VHN++VVD L + G IE Sbjct: 1 MEIISVQPRGYCHGVVRAIRLAQKTRETYPHTTMTILGMLVHNQHVVDELAKNGIHTIED 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASR 111 + ++ +G I++F+AHGVS AV +AK + L + DATCP V K H + Sbjct: 61 HHQDRLSLLDKIQEG-IVVFTAHGVSPAVYEKAKEKGLQIVDATCPDVLKTHELIRNHPG 119 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSV 171 I +G HPE EGT+G ++LV +D+ L + QTTLS+ Sbjct: 120 D---VIYLGKKNHPEAEGTIG----LSSRVHLVSCVEDLNTLQSFPLQDPIITNQTTLSL 172 Query: 172 DDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRL 231 D D+I A K++P +IC AT RQEA+ L + +V+ VVG S+NSN+L Sbjct: 173 LDLQDLITACLKQYPNA--KVVREICPATRLRQEAILNL--ETDVLYVVGDVRSNNSNQL 228 Query: 232 AELAQRMGK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQ 284 +A++ G +I D+QE + E K + VT+G+S P+ L V++ LQ Sbjct: 229 VNIARKKGISFVKMISSVHDLQEHEIIEKKRIAVTSGSSTPNTLTNQVISFLQD 282 >UniRef50_Q0DNV6 Os03g0732000 protein n=4 Tax=Embryophyta RepID=Q0DNV6_ORYSJ Length = 482 Score = 271 bits (693), Expect = 3e-71, Method: Composition-based stats. Identities = 78/360 (21%), Positives = 152/360 (42%), Gaps = 72/360 (20%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIF--- 56 ++++LA GFC GVD A+ + +A + +++ ++++HN V + L E G Sbjct: 123 VRLILAEAHGFCLGVDNAVRLAYDARVKFPDRRLWLTNQIIHNPTVSERLDEMGIKIIPV 182 Query: 57 ---IEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRG 113 ++ +S V DG ++IF A G + +++ + D TCPLV KV R + Sbjct: 183 VSGVKDLSVVEDGDVVIFPAFGFTVDEMVTLNRKNVHIVDTTCPLVLKVVHMTERHIKGN 242 Query: 114 EESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL-------------------- 153 +I+ G H E T +V+ + + Sbjct: 243 YTTIIHGKYAHEETVATASFADKY----IIVKDITEAKYVCDYILEGQLDGSSSTKEKFL 298 Query: 154 ------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKD------- 194 + E++ + QTT+ +T ++ + + G ++ Sbjct: 299 KKFRYAVSPGFDPDIDLERVGVVNQTTMLKGETKEIGILIEQTMMSKYGLDQNNKQEHFV 358 Query: 195 ---DICYATTNRQEAVRALA-EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD 250 IC AT RQ+A+ L ++ +++LVVG NSSN++ L E+ + G ++ +D + Sbjct: 359 RVGTICNATQERQDAMYKLVEKEVDLILVVGGWNSSNTSHLQEIGELSGIPSYWVDGEQR 418 Query: 251 I-----------------QEEWV-KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 I +++W+ +GVT+GAS PD +V++V+ ++ ++ E Sbjct: 419 IGPGNKISYKQKNGELVEKDKWLPHGAITIGVTSGASTPDKVVEDVLQKVFEIKRQELGE 478 >UniRef50_C1AAK2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AAK2_GEMAT Length = 437 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 84/361 (23%), Positives = 131/361 (36%), Gaps = 75/361 (20%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGAP-IYVRHEVVHNRYVVDSLRERGAIFIE--- 58 I LA GFC GV+RA+ + I++ E++HN +V L+E G IF+ Sbjct: 73 IRLAREFGFCYGVERAVDYAYQTRRKFPERRIFLAGEIIHNPHVNAKLQEMGVIFLSAKG 132 Query: 59 ---QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + V ++I A GV+ + V D TC V V V +R G Sbjct: 133 KGFDYAPVEPKDVVILPAFGVTIQDFQTLRELGCVVVDTTCGSVLNVWKRVEAYARDGFT 192 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMY-LVESPDDVWKL--------------------- 153 S++ G H E T Q GG Y +V + + Sbjct: 193 SLIHGKYYHEETRATASQVEKYNGGQYLVVRDMAEAELVMDYLEDRAGVQPAREPLSREA 252 Query: 154 --------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRF--------PKIVGP 191 + E++ QTT+ ++ + A+ + Sbjct: 253 FLERFAKAASDGFDPDVHLERVGVANQTTMLARESLAIGAAVGESMTRGYGEAHRAEHFR 312 Query: 192 RKDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD 250 D IC AT +RQ+AV L ++++VVG NSSN+ LA L + I D + Sbjct: 313 TFDTICSATQDRQDAVMELLRDPLDLMVVVGGYNSSNTISLAALCAEQ-VPTYHIADPDE 371 Query: 251 IQ--------------------EEWVK--EVKCVGVTAGASAPDILVQNVVARLQQLGGG 288 I W+ +G+TAGAS P+ + VAR+ + G Sbjct: 372 IDVAENRVRYRRIGAKHHEDEMSSWLPTTGPLRIGITAGASTPNNKIGQAVARVFAIRGV 431 Query: 289 E 289 + Sbjct: 432 D 432 >UniRef50_B7IE33 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IE33_THEAB Length = 811 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 78/292 (26%), Positives = 140/292 (47%), Gaps = 21/292 (7%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 MQI +A GFC GV++A+++ + L G ++ ++VHN+ V++ L G + Sbjct: 1 MQIKIAKGIGFCFGVEKAVNVTKELLKS-GKNVFTDDDIVHNKQVMEELERLGLSY---- 55 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 +G I + AHG+ + + K V D TC +V + V +G + ++ G Sbjct: 56 ---DNGDIYLIRAHGLPKEKIEKIKKEH-RVVDLTCNIVYNLFKTVEVYENKGYQVVVYG 111 Query: 121 HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDA 180 HPE+ N + +E V +K+ +QTT+S D + + Sbjct: 112 KITHPEMIALKSYSKN---AIITMEPL-------VIKSDKIFVASQTTMSYKDFENFYNK 161 Query: 181 LRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK 240 L+ + IC T NR+ V L+++ ++++VVG K+SSN+ +L +A + Sbjct: 162 LKDISIYNEFKVFNSICNITHNREIEVEKLSKEVDLMIVVGGKHSSNTRKLFNIASQH-T 220 Query: 241 RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 +A I+ +I +E K V VG+ +G S P +V+ + A L++LGG + Sbjct: 221 KAIHIETIDEI-KEIPKGVDSVGIISGTSTPKEIVEEIAAGLKKLGGMLQME 271 >UniRef50_B3DZ81 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH n=5 Tax=Verrucomicrobia RepID=B3DZ81_METI4 Length = 419 Score = 264 bits (676), Expect = 3e-69, Method: Composition-based stats. Identities = 84/355 (23%), Positives = 144/355 (40%), Gaps = 65/355 (18%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYG-APIYVRHEVVHNRYVVDSLRERGAIFIEQ-- 59 + LA GFC GV+RAI + ++ I++ E++HN V D L G ++ Sbjct: 53 VKLAKAFGFCYGVERAIDLAYATTKVFPTKRIFLLGEIIHNPEVNDQLTAMGIKRLQAVE 112 Query: 60 ----ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 + + ++I A G + + D TC V V V + + G Sbjct: 113 GGYFLDGLTADDVVIIPAFGAEVETMKRIQQIGCQIVDTTCGDVMTVWKRVRQYRKEGAT 172 Query: 116 SILIGHAGHPEVEGTMGQY--SNPEGGMYLVESPDDVWKLTVK----NEEK--------- 160 SI+ G A H E + T + + G +V + ++ + ++K Sbjct: 173 SIIHGKAWHEETKATASRAIGEDGNGHYLVVYNLEETDYVCNYIRYGGDKKEFLEKFKGA 232 Query: 161 -------------LSFMTQTTLSVDDTSD----VIDALRKRFP----KIVGPRKDDICYA 199 + QTT+ +T + + A+ R+ D IC A Sbjct: 233 VSPGFDPDVHLCHVGVANQTTMMRGETEEVQRRICKAIEDRYGKENLHEHFRFFDTICGA 292 Query: 200 TTNRQEAVRAL--AEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKD------- 250 T RQ+A+ + E+ ++++VVG NSSN++ LAE+ + + I +A+ Sbjct: 293 TQERQDALLDMLDKEKLDLLIVVGGYNSSNTSHLAEIGESR-LPTYFIKNAEKLISTRQI 351 Query: 251 -----------IQEEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 I E W+KE + VG+TAGAS P+ L++ + RL +L G L Sbjct: 352 QHWDLHKGQEVITEGWLKEGEINVGITAGASCPNNLIEETIQRLFELRGIGVETL 406 >UniRef50_Q14P56 Probable 4-hydroxy-3-methylbut-2-enyl diphosphate reductase protein n=1 Tax=Spiroplasma citri RepID=Q14P56_SPICI Length = 293 Score = 262 bits (671), Expect = 1e-68, Method: Composition-based stats. Identities = 91/298 (30%), Positives = 152/298 (51%), Gaps = 18/298 (6%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIEQ 59 M+++ PRG+C GV ++I + A Y G IY+ +VHN++V+D + G I + Sbjct: 1 MKVVKVTPRGYCLGVVKSIKWAKEAAIKYAGRQIYMLGYLVHNKHVIDEIVNLGVIPVND 60 Query: 60 --------ISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARA-S 110 I +PD A++I SAHG +++ A +++T+ D C VT + + Sbjct: 61 FKLNRLELIQTLPDNAVVILSAHGSDDRIKDVAVQKNITLVDTECEWVTVTKNLIKEYLA 120 Query: 111 RRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL--TVKNEEKLSFMTQTT 168 + + I IG HPE + + LV + +V + + +K+ QTT Sbjct: 121 KPDYQIIFIGKHFHPETNAMLALSP----TINLVTTEQEVVSILPNLDPTKKILITNQTT 176 Query: 169 LSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSN 227 LS D +++ L+ P K+D+C AT RQ AV +L +++LVVG + SSN Sbjct: 177 LSKIDIEAIVEKLKTLVPN-EIIFKNDLCNATLERQNAVLSLDPTTIDLLLVVGDERSSN 235 Query: 228 SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + +L + +++G ++ I+D DIQ W+ CV VTAGAS P I+ V+ L+Q+ Sbjct: 236 TLKLVAMGEQIGIESYRINDKSDIQPTWLANKTCVAVTAGASTPSIIQLEVIRYLEQI 293 >UniRef50_Q1ATX3 Hydroxymethylbutenyl pyrophosphate reductase n=2 Tax=Bacteria RepID=Q1ATX3_RUBXD Length = 410 Score = 260 bits (664), Expect = 6e-68, Method: Composition-based stats. Identities = 89/359 (24%), Positives = 146/359 (40%), Gaps = 69/359 (19%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFI---- 57 + LA+ GFC GVDRA+ + I++ +++HN + LRE G F+ Sbjct: 47 LRLADEFGFCYGVDRAVDYAFQTREKFPDRRIFLTGDMIHNASMNARLREMGIEFLSQGF 106 Query: 58 -----EQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRR 112 E+ ++ + ++I A G + + R + D TC V V VAR +++ Sbjct: 107 DGRPDERFEDLDEEDVVILPAFGAPVEWVGKLRERGCIIVDTTCGSVLSVWKRVARYAQK 166 Query: 113 GEESILIGHAGHPEVEGTMGQY--SNPEGGMYLVESPDDVWKL----------------- 153 G SI+ G H E T Q G +V + L Sbjct: 167 GFTSIIHGKYYHEETRATASQTRREGGNGKYLIVRDLKETGYLTDFIRGRTSAGELKERL 226 Query: 154 ---------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RKDDI 196 ++ ++ QTT+ + +T V + +RK + G D I Sbjct: 227 GHGMSPGFDPERDLVRVGVANQTTMLMTETMKVGEEIRKAMEERYGRENLAEHFELFDTI 286 Query: 197 CYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLI---------- 245 C AT +RQ+A+ L E +VV++VG NSSN+N LA +A R++ I Sbjct: 287 CSATQDRQDALMRLLEHPLDVVVIVGGYNSSNTNNLAIIAAGRVPRSYHIANGECIRGAS 346 Query: 246 ----------DDAKDIQEE-WV-KEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 D ++++EE W+ + VG+TAGAS P+ + V R+ + G Sbjct: 347 IRHKPPGTPLDPREEVEEEGWLPEGPVRVGLTAGASTPNSQIGLAVRRILEARGIRVEE 405 >UniRef50_Q2S1D9 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=6 Tax=Sphingobacteriales RepID=Q2S1D9_SALRD Length = 413 Score = 259 bits (663), Expect = 9e-68, Method: Composition-based stats. Identities = 85/356 (23%), Positives = 144/356 (40%), Gaps = 70/356 (19%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIY-GAPIYVRHEVVHNRYVVDSLRERGAIFIE- 58 ++ +A GFC GV++AI I AL I++ E++HN +V + LR+RG F+ Sbjct: 42 VRFKIARHFGFCFGVEQAIEIAYEALEENPDKRIFLLSEMIHNPHVNEDLRDRGIQFLRT 101 Query: 59 -------QISEVPDGAILIFSAHGVSQAVRNEAKSRDL--TVFDATCPLVTKVHMEVARA 109 E+ ++I A G + V + + + +D TCP V KV + ++ Sbjct: 102 TQGEQLIPFDELTPDDVVIIPAFGTTLEVEQKLEEIGVDTEAYDTTCPFVEKVWRKSSQI 161 Query: 110 SRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL---------------- 153 ++ G H E T EG + +V ++ +L Sbjct: 162 GDDDHSIVVHGKRYHEETRATFSHAK-EEGPVVVVRDMEEAEELAKVIRGEKDADFFYDY 220 Query: 154 ----------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK---------D 194 ++ +KL + QTT+ ++T+ + D +R + G D Sbjct: 221 FEDKYSEDFDPERDLQKLGVVNQTTMLAEETAAIADLMRDAMRERYGEAHVEERFADTSD 280 Query: 195 DICYATTNRQEAVRALAEQ-AEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQ- 252 +CYAT Q A +AL E A++ +VVG NSSN++ L EL + + I DA + Sbjct: 281 TLCYATNENQNATQALIEDGADLGIVVGGYNSSNTSHLVELCEEHM-PTYFIRDASEFDA 339 Query: 253 -----------------EEWVKEVKC---VGVTAGASAPDILVQNVVARLQQLGGG 288 ++W V +T+GAS PD L+ VV ++ Sbjct: 340 PSEIHHFDVHAKEEVATDDWFPAEDTPVDVLLTSGASCPDALLDEVVRKIISWFPD 395 >UniRef50_A7HME7 Hydroxymethylbutenyl pyrophosphate reductase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HME7_FERNB Length = 854 Score = 257 bits (658), Expect = 3e-67, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 143/321 (44%), Gaps = 25/321 (7%) Query: 4 LLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEV 63 ++ GFC GVD A+ + + L G ++ EVVHN+ V++ L+ G + Q Sbjct: 12 IIVGQYGFCFGVDNAVREIIDHLNK-GENLFTDGEVVHNKNVLEELKRLGLKYSPQ---- 66 Query: 64 PDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAG 123 + + AHG+ NE S++ V D TCP+V + + S+ G + + G Sbjct: 67 -ENGTFVVRAHGLPPEKLNEI-SKNYKVIDLTCPIVQNLFALGKKLSKEGYKVVAFGKKD 124 Query: 124 HPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRK 183 H E+ G N L + + K++ ++QTT S + + I+ ++K Sbjct: 125 HAEMVAFAGHVKNSLVTT---------EPLPL-LDNKIAIISQTTSSSEKFALFIEEMKK 174 Query: 184 RFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAF 243 + IC T R+E + LA+ V+VVG KNSSN+ +L E+A GK Sbjct: 175 LNKGKEIKVINTICKVTIEREEQAKKLAQICNFVVVVGGKNSSNTKKLFEIAYNYGKAVH 234 Query: 244 L--IDDAKDIQEEWVKEVK------CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEG 295 + I++ +I+E +E +G+ +G S V++++ L + GG + +E Sbjct: 235 IESINEINEIEEMLFREKSKDIQTIKIGLISGTSTYSKDVEHILKYLVKNYGGRELYMED 294 Query: 296 REENIVFEVPKELRVDIREVD 316 + + ++E + Sbjct: 295 LNNLKQEVLEESFEQLLKEHE 315 >UniRef50_C2MBA3 LytB protein n=14 Tax=Bacteria RepID=C2MBA3_9PORP Length = 306 Score = 256 bits (654), Expect = 1e-66, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 126/293 (43%), Gaps = 15/293 (5%) Query: 2 QILLANPRGFCAGVDRAISIVENALA-IYGAPIYVRHEVVHNRYVVDSLRERGAIFIE-- 58 ++ + GFC GV +A+S E L +G P+Y ++VHNR VD L G I+ Sbjct: 9 RVEIDPESGFCFGVIKAVSRAEEILRQEHGEPLYCLGDIVHNRAQVDRLESLGMRTIDHE 68 Query: 59 QISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVAR----ASRRGE 114 Q S + + A +++ AHG A A + V DATCP+V ++ +V + + Sbjct: 69 QFSHLSN-ARVLYRAHGEPPASYTYAAENGIEVVDATCPVVLRLQQKVRQAYLQHANDDT 127 Query: 115 ESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDT 174 + ++ G GH EV G +GQ +G +V P D+ + + +QTT+ D Sbjct: 128 QIVIFGKPGHAEVNGLVGQ---TDGKAIVVREPKDLDLVDF--ARSIELFSQTTMQEDQL 182 Query: 175 SDVIDALRKRFPKIVGPR-KDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAE 233 +++ ++ R + IC + R +R A+ + + V + SSN L + Sbjct: 183 EEMLSLIQSRLSDTATLVSHNTICQQVSRRIPNIREFAKSHDRIFFVSDQKSSNGRVLYQ 242 Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEV-KCVGVTAGASAPDILVQNVVARLQQL 285 + I ++ + V + +GV S +Q + + + Sbjct: 243 NCLEVNPNTTFITYPSELTYDLVPSHEESIGVCGATSTSREQLQEIAEIITRW 295 >UniRef50_D2ASB2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2ASB2_STRRD Length = 420 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 93/291 (31%), Positives = 153/291 (52%), Gaps = 4/291 (1%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA R C G RA+ I + G ++ V + + +L G + + Sbjct: 118 RVLLAGTRPACPGARRALEITRDTA-GGGQAVFSYGPVTDDPHQAGALTREGVTTVTDLD 176 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 +P+GA ++F AHGVS A+R EA +R LT+ DATCPLV H EVAR + RG+ +++IG Sbjct: 177 RLPEGAGVVFPAHGVSLALRAEAAARGLTIIDATCPLVAAAHAEVARFTERGDLTVVIGR 236 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 +G V +GQ LVES DV +L + E +S++ QT + V+ + V+ AL Sbjct: 237 SGDAAVSAVLGQAP---ESTVLVESAADVERLRPADPEAISYLVQTGIPVEQATPVVAAL 293 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R RFP + GP D CY ++R AV ++ ++++L+ + ++ + LA+ G Sbjct: 294 RARFPALRGPDPGDFCYHASDRASAVASITGASDLLLIAAGSHCPDARHVVRLAEPAGVP 353 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIP 292 A ++ D+ + ++E V +T+ SAP L + +V L LG + Sbjct: 354 AQVVTGVADLCPDRLREAATVALTSARSAPAGLSEQIVTILSGLGPLGVVN 404 >UniRef50_B5JMM5 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM5_9BACT Length = 543 Score = 248 bits (635), Expect = 2e-64, Method: Composition-based stats. Identities = 96/374 (25%), Positives = 149/374 (39%), Gaps = 84/374 (22%) Query: 2 QILLANPRGFCAGVDRAISIVENALA-IYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 + LL + GFC GV AI LA G +++ E++HN +V + L+ RG +++ Sbjct: 159 EYLLPSHFGFCLGVQNAIERAYETLAANPGKRVFMLSELIHNPFVNEDLQARGLKYLQSD 218 Query: 61 SEVP---------------DGAILIFSAHGVSQAVRNEAKSRDLTV--FDATCPLVTKVH 103 VP D I+I A G + R L + +DATC LV KV Sbjct: 219 KGVPLIEEATGRPYWDGLSDADIVIIPAFGARDEDKLRLIERGLPIRQYDATCMLVEKVW 278 Query: 104 MEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYL--------------VESPDD 149 R +G ++ G A H E + T + + + +S ++ Sbjct: 279 KAARRYGEQGYTIVIHGKAEHEETKATFSNSAKYAPSVVIRDIKEASILGEVIRAKSKEE 338 Query: 150 VWKL-------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--- 193 +L K+ ++L+ + QTTL ++T +I L + + G Sbjct: 339 KQRLFEPFVSRASVGFDPSKDLDRLALVNQTTLLRNETLKIIAYLEETLAETYGEAHVKE 398 Query: 194 --------DDICYATTNRQEA-VRALAEQAEVVLVVGSKNSSNSNRLAELAQRM-GKRAF 243 D +CYAT Q+A +AL E + +VVG KNSSN+ +L L Q G+RAF Sbjct: 399 HLAMSSKGDTLCYATQVNQDALAKALDEDIDAAIVVGGKNSSNTFQLFRLCQERFGERAF 458 Query: 244 LIDDA------KDIQEEWV--------------------KEVKCVGVTAGASAPDILVQN 277 I +I+ KE V VT GAS PD ++Q Sbjct: 459 YIQSEANILSRDEIEHFIFPYNPGDPKQGVMETRAFLPEKERVKVLVTGGASCPDGILQQ 518 Query: 278 VVARLQQLGGGEAI 291 ++ R+ E I Sbjct: 519 IICRINGFHAPERI 532 >UniRef50_B5Y8P7 LytB protein n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8P7_COPPD Length = 282 Score = 241 bits (616), Expect = 3e-62, Method: Composition-based stats. Identities = 79/287 (27%), Positives = 128/287 (44%), Gaps = 23/287 (8%) Query: 1 MQI-----LLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAI 55 M++ LA P+G C GV R+I + L +G ++ H +VHN V+ L + G I Sbjct: 1 MKVCKKELHLAFPQGPCFGVKRSIELCRKILEKHGT-VFAVHPLVHNEIVMADLAKHGLI 59 Query: 56 FIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEE 115 E + ++P + ++ SAHG + V K ++ V DA CPLV VH + A + + Sbjct: 60 LEEDVEKIPSNSWVVLSAHGTPKDVLERLKEKNCKVVDAVCPLVLFVHKKALEAVKNFGK 119 Query: 116 SILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTS 175 ++G + H E+ + G Y++ P+ +++ + Q+T T Sbjct: 120 VNIVGDSQHQEIRALTSELP---EGSYVLCGPEGKLA-----DKRFPVVFQST-----TD 166 Query: 176 DVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELA 235 + + D IC AT RQ+A L E + ++++GS S+NS LA A Sbjct: 167 PI---ILHELDAEGYRIMDTICTATKGRQQANAQLIENCDALIILGSSTSANSRHLAAKA 223 Query: 236 QRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 GK L D + + VG+ AGAS P LV R+ Sbjct: 224 SASGKPVLLTLDLDE-AASFALNYDIVGIIAGASTPLDLVYQAYDRI 269 >UniRef50_C4DRD7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DRD7_9ACTO Length = 407 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 85/300 (28%), Positives = 146/300 (48%), Gaps = 8/300 (2%) Query: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 ++LLA +C G R + +VE+ L ++V ++ + +LRERG + + + Sbjct: 116 RVLLAGGEPWCVGGRRVVELVESTLDDGAELVHVVGDLAASPERRVALRERGVVPVTALD 175 Query: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 EVPDGA ++ A G+ + R +A R + + D TCP + +V R + RG+ +L+G Sbjct: 176 EVPDGARVVVGAAGIPEEQRVKAAKRGVRIVDGTCPHIASGKAQVRRYAERGDAVVLVGQ 235 Query: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 GH E GQ + +VE+ DV ++ + + +S + ++++ ++ AL Sbjct: 236 RGHASTEALSGQAPD---ATLVVETTADVEQM--RGGDGVSAVPVPSMAIGAVVPMLAAL 290 Query: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 R+RFPK+ D CY T +R VR LA A+VV V+G S + RL ++A Sbjct: 291 RRRFPKLPVQHPDQWCYQTQDRLATVRELAGTADVVFVLGPPESPETVRLLDVAAS---N 347 Query: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 A + DI+ ++ +V VGV G A + L ++ L LG L + + Sbjct: 348 AVAVGGLGDIEPSYLVDVGSVGVVVGGDASEGLRGELLTALGGLGPVAVSELRVQTRTMD 407 >UniRef50_Q89AV1 Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase homolog n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=ISPH_BUCBP Length = 221 Score = 213 bits (543), Expect = 7e-54, Method: Composition-based stats. Identities = 79/215 (36%), Positives = 130/215 (60%), Gaps = 1/215 (0%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M+ILL NPR FC RA+SIV AL +G IYV H++VHN Y++++L+ +G IF + I Sbjct: 1 MKILLENPRSFCVETKRALSIVNLALKTWGKLIYVNHKIVHNNYIINNLKLKGVIFSKNI 60 Query: 61 SEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG 120 + + + + L+ S H V ++ + + + DATCPLV KVH ++ ++ ILI Sbjct: 61 NSILESSKLMLSKHSVPNKIKKTTLEKKIFIIDATCPLVKKVHKKIHYKNKNTYNVILIE 120 Query: 121 HAGHPEVEGTMG-QYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 ++ HP+++GT+ N + +Y+V+S KLT+KN Q TLS + +I Sbjct: 121 NSQHPKIQGTLERYQKNLKNSIYIVKSKKYAIKLTIKNTRNSIITAQITLSSEKIYPIIT 180 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQA 214 LRK+FP I+ +++ICYAT NR+ A++ ++++ Sbjct: 181 ILRKKFPAIINSHENNICYATINRKTAIKHISKKI 215 >UniRef50_Q4PKE9 Predicted 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=uncultured bacterium MedeBAC82F10 RepID=Q4PKE9_9BACT Length = 191 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 83/192 (43%), Positives = 128/192 (66%), Gaps = 3/192 (1%) Query: 119 IGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVI 178 IGH GHPEVEGT GQ + + LV+ +DV KL +++K++++TQTTLSV DT +++ Sbjct: 2 IGHEGHPEVEGTAGQLQDI-SKLTLVQELNDVEKLYFPSDQKIAYITQTTLSVFDTQEIV 60 Query: 179 DALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRM 238 DAL K+FP+I+ P+K DICYAT+NRQ +VR +A+ + V+G+ NSSNS RL E A++ Sbjct: 61 DALEKKFPEILAPKKSDICYATSNRQTSVREMAKNVDAFFVIGAFNSSNSIRLVETAKKF 120 Query: 239 GK-RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGRE 297 G + LI++ D + + + + +G+TA ASAP+ + + R+++ E I + + Sbjct: 121 GCEDSELIENIDDFDYQKLNQYQSIGLTASASAPEEQLNLFIDRVKENFSPEVIDFK-ED 179 Query: 298 ENIVFEVPKELR 309 ENIVF+VP L Sbjct: 180 ENIVFKVPNFLN 191 >UniRef50_A8V303 LytB protein n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V303_9AQUI Length = 167 Score = 203 bits (516), Expect = 8e-51, Method: Composition-based stats. Identities = 50/166 (30%), Positives = 98/166 (59%), Gaps = 3/166 (1%) Query: 120 GHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVID 179 G GHPEV GT+G G +V + +++ K + K+ + QTT S D + + Sbjct: 2 GEHGHPEVIGTLGHLEESGGRGIVVSNMEELVK-NLPRTSKVGVVAQTTQSEDFFREAVG 60 Query: 180 ALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMG 239 + + ++ + IC AT+ RQE V+ +A +V++++G K+S N+NRLA++++ + Sbjct: 61 YIAENIEEV--KIFNTICDATSVRQEEVKKIAPNVDVMIIIGGKHSGNTNRLAQISRYLN 118 Query: 240 KRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQL 285 + I+ A +I+ +W++ + +G++AGAS PD ++ VV ++++L Sbjct: 119 PDTYHIEKADEIEPKWLEGKEKIGISAGASTPDWIINEVVEKVKKL 164 >UniRef50_A7C5H7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Beggiatoa sp. PS RepID=A7C5H7_9GAMM Length = 214 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 80/148 (54%), Positives = 110/148 (74%) Query: 138 EGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDIC 197 + M+++ +P++V L+VKN ++L+++TQTTLS+DDT DVI AL RFP I GP +DIC Sbjct: 2 DETMHVLCTPEEVMALSVKNPKQLAYVTQTTLSLDDTRDVIAALTTRFPNIKGPALNDIC 61 Query: 198 YATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVK 257 YAT NRQ AVR LA EV+LVVG+ NSSNSNRL E+ + G +A+LI+DA+D+Q +W Sbjct: 62 YATQNRQNAVRQLANDVEVLLVVGANNSSNSNRLREVGTQAGVQAYLIEDAEDLQPQWFA 121 Query: 258 EVKCVGVTAGASAPDILVQNVVARLQQL 285 VG+TAGASAP++LV+ V+ RL Sbjct: 122 NRPTVGITAGASAPEVLVEGVLQRLNNF 149 >UniRef50_UPI0000D54C36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D54C36 Length = 166 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 72/165 (43%), Positives = 112/165 (67%), Gaps = 1/165 (0%) Query: 149 DVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVR 208 DV L V++ + L+++TQTTLS+DDT V+ AL+K+FP I GP K+DICYATTNRQ AV+ Sbjct: 2 DVQNLEVRDTQNLAYVTQTTLSIDDTFSVVQALQKKFPAIQGPHKEDICYATTNRQLAVK 61 Query: 209 ALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR-AFLIDDAKDIQEEWVKEVKCVGVTAG 267 +A + + +LVVG+ NSSNS RL E+ +R G + + L+ A +I ++ ++ +G+TAG Sbjct: 62 EIANKIDALLVVGAPNSSNSKRLVEVGKRAGCKYSQLVQRASEIDFRALEGIENLGITAG 121 Query: 268 ASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDI 312 ASAP++L+ V+ ++ + +E EN+ F+VP+ LR Sbjct: 122 ASAPEVLIDEVINSFRETHLVDVEIVETAVENVNFKVPRVLREPA 166 >UniRef50_C5KI36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5KI36_9ALVE Length = 429 Score = 172 bits (437), Expect = 1e-41, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 109/307 (35%), Gaps = 92/307 (29%) Query: 54 AIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLT--VFDATCPLVTKVHMEVARASR 111 + ++ ++EV ++ + V E +DA V V R + Sbjct: 124 LVPVDPVNEVTP---VLERGYAVVNETYMELHFEHPHAWFYDA-------VWSSVERHKK 173 Query: 112 RGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKL------------------ 153 SI+ G + H E T ++++ D + Sbjct: 174 GEYTSIIHGKSKHEETIATSSFADKY----LILKNLKDAEYVCKFLLSKNKERLVNDFFE 229 Query: 154 ------------TVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGP--------RK 193 +K+ EK+ QTT+ +T+ + K ++ GP Sbjct: 230 KFPADRHSVGFDPLKDLEKVGVANQTTMLKGETALIAKLFEKTVLQLYGPEGLNEHFVAF 289 Query: 194 DDICYATTNRQEAVRAL----AEQAEVVLVVGSKNSSNSNRLAELAQRMG----KRAFLI 245 + IC AT +RQ+A+ L A + +++LVVG NSSN+ L E++ G RAF I Sbjct: 290 NTICDATQDRQDALYKLVTPTATKLDMMLVVGGFNSSNTEHLQEISVEAGGVKDHRAFHI 349 Query: 246 DDAKDIQE---------------------------EWVKEVK---CVGVTAGASAPDILV 275 D I E +++ +GVT+GAS PD ++ Sbjct: 350 DGPARIDELRNTITHKPVETPPIEAARNHGLAVTHDFLPGNGEHITIGVTSGASTPDDVL 409 Query: 276 QNVVARL 282 + + +L Sbjct: 410 EQSLQKL 416 >UniRef50_Q6LH35 Putative uncharacterized protein n=1 Tax=Photobacterium profundum RepID=Q6LH35_PHOPR Length = 304 Score = 132 bits (333), Expect = 2e-29, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 84/239 (35%), Gaps = 32/239 (13%) Query: 42 NRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTK 101 N L E G + ++++P+GA + + + A + K+ + V D CP V K Sbjct: 57 NP---KMLEELGVNVVPTVADLPEGAGVFVTGYDADYAELQQLKADGVPVIDRPCPWVRK 113 Query: 102 VHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNP--EGGMYLVESPDDVWKLT-VKNE 158 + ++ + +L+ H + +V+ + ++ +K Sbjct: 114 LRDQILSFDNESYQMVLVIDENH-----MVYDCFKNLIPSDAIIVQPQNFKERICHLKLS 168 Query: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKD---DICYATTNRQ---EAVRALAE 212 LS ++ T D + + + + +P + +C T Q E V + Sbjct: 169 RPLSLLSYTVFRRTDIEAMAEFILQEYPNQEHHLHNYKKTLCLWTK--QGLFEEVEDKCQ 226 Query: 213 QA--EVVLVVGSKNSSN-----SNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGV 264 + V ++ SN + L + + +I+ DI + K +GV Sbjct: 227 SHRLDEVWII----CSNRGDRSTQSLIQQVEDSQAIPVIIEKVADIPSR--NDKKKIGV 279 >UniRef50_Q7MUK6 LytB-related protein n=2 Tax=Bacteria RepID=Q7MUK6_PORGI Length = 316 Score = 122 bits (307), Expect = 2e-26, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 75/189 (39%), Gaps = 14/189 (7%) Query: 49 LRERGAIFIEQISEVPDGA--ILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEV 106 ++ G +++ +++P+G +++ + + + + + + D CP V K+ E Sbjct: 60 FKKLGVPYVKTYNDLPEGNDFVVVNTGYDSIVHEEKVLREKGVEILDKPCPFVRKLRKEF 119 Query: 107 ARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWK-LTVKNEEKLSFMT 165 + + +L+ + H + M L++ + K L N + + F++ Sbjct: 120 EK-IDDSYQYVLLCESNH---IIIKNFATIFPRDMILIQMGNYKEKLLEQSNGKPMMFIS 175 Query: 166 QTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQ---EAVRALA----EQAEVVL 218 T + V D + K FP D C R + +R ++ ++ L Sbjct: 176 YVTFLKKHSIQVFDFINKTFPGKDHKMVDTQCMWAAGRLSPIDEIRNMSEDILKEVRYAL 235 Query: 219 VVGSKNSSN 227 ++GS S+N Sbjct: 236 LIGSPGSTN 244 >UniRef50_C0AZ30 Putative uncharacterized protein n=2 Tax=Gammaproteobacteria RepID=C0AZ30_9ENTR Length = 97 Score = 122 bits (306), Expect = 2e-26, Method: Composition-based stats. Identities = 61/94 (64%), Positives = 72/94 (76%) Query: 223 KNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARL 282 KNSSNSNRLAELAQR GK ++LID +DI E WV VGVTAGASAPDILVQ V+ RL Sbjct: 4 KNSSNSNRLAELAQRAGKPSYLIDSFEDIDESWVANANIVGVTAGASAPDILVQQVLERL 63 Query: 283 QQLGGGEAIPLEGREENIVFEVPKELRVDIREVD 316 + G + + L GREENIVFEVPKELR+D + ++ Sbjct: 64 KTFGADDVVELSGREENIVFEVPKELRLDYKVIE 97 >UniRef50_UPI000190F3D8 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E01-6750 RepID=UPI000190F3D8 Length = 83 Score = 99.4 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 67/83 (80%), Positives = 76/83 (91%) Query: 234 LAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPL 293 +AQRMG+ AFLIDDA DIQE WVK+ CVGVTAGASAPDILVQNV+ARL++ GGGEA+ L Sbjct: 1 MAQRMGRTAFLIDDAADIQEAWVKDAACVGVTAGASAPDILVQNVIARLREFGGGEAVTL 60 Query: 294 EGREENIVFEVPKELRVDIREVD 316 EGREENIVFEVPKELRVD+REV+ Sbjct: 61 EGREENIVFEVPKELRVDVREVE 83 >UniRef50_C0CI73 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CI73_9FIRM Length = 83 Score = 98.6 bits (245), Expect = 3e-19, Method: Composition-based stats. Identities = 28/78 (35%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 1 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQI 60 M + +A GFC GV RA+ V + PIY ++HN VV L +G IE I Sbjct: 1 MNVKVAEHAGFCFGVRRAVDKVYELIESQEKPIYTLGPIIHNESVVGDLEAKGVKVIENI 60 Query: 61 SE---VPDGAILIFSAHG 75 + V DG ++I S+ G Sbjct: 61 EQLHSVRDGVVVIRSSRG 78 >UniRef50_B8KX15 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KX15_9GAMM Length = 66 Score = 72.1 bits (176), Expect = 3e-11, Method: Composition-based stats. Identities = 33/63 (52%), Positives = 39/63 (61%) Query: 251 IQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRV 310 I+E W+ VGVTAGASAP+ LVQ+VV LQ G E PL G ENI F +PK LR+ Sbjct: 2 IEEGWLTPESVVGVTAGASAPEALVQDVVTALQARGADEVTPLNGEPENITFSLPKGLRI 61 Query: 311 DIR 313 Sbjct: 62 PAA 64 >UniRef50_Q075K0 Plastid lyt B-like protein (4-hydroxy-3-methylbut-2-enyl diphosphate reductase) (Fragment) n=1 Tax=Prototheca wickerhamii RepID=Q075K0_PROWI Length = 189 Score = 68.2 bits (166), Expect = 3e-10, Method: Composition-based stats. Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGA-PIYVRHEVVHNRYVVDSLRE 51 ++LA GFC GV+RA+ I A Y +++ +E++H V + LR Sbjct: 95 VVLAEAYGFCWGVERAVQIAYEARHRYPEAEVHITNEIIHKPSVNERLRR 144 >UniRef50_D2MHW9 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHW9_9BACT Length = 55 Score = 59.4 bits (143), Expect = 2e-07, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 29/49 (59%) Query: 261 CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 309 VG+++GAS P+++++ ++A+L+ LG +EE+ F P L Sbjct: 3 TVGISSGASTPEVIIEELLAKLKDLGASTFEEFSLKEESTKFPFPHSLE 51 >UniRef50_Q5YBC4 Plastid ispH (Fragment) n=1 Tax=Helicosporidium sp. ex Simulium jonesi RepID=Q5YBC4_HELSJ Length = 113 Score = 57.0 bits (137), Expect = 9e-07, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 39/107 (36%), Gaps = 25/107 (23%) Query: 222 SKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEE-------------------WVKEVK-- 260 S+ + G ++ +D A I E W+ K Sbjct: 9 GAESARGRD----GEMNGVASYWVDSAARIDVENNAIAHKTAHGRAGGVTQNWLTPGKPI 64 Query: 261 CVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKE 307 CVGVT+GAS PD V+NV+ + ++ + E + + P E Sbjct: 65 CVGVTSGASTPDRSVENVLDCIFRIYDPSFQGIPVLEHDTALDRPSE 111 >UniRef50_Q4E9V2 Hydroxymethylbutenyl pyrophosphate reductase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9V2_9RICK Length = 52 Score = 51.6 bits (123), Expect = 4e-05, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 258 EVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLE-GREENIVFEVPK 306 V+ +G+TAGASAPDILV ++ L+ E + G EN+ F++P Sbjct: 1 GVEKIGITAGASAPDILVDELMDYLKVSMNVEVSVMPGGIIENVQFKIPN 50 >UniRef50_C5IH56 At4g34350-like protein (Fragment) n=3 Tax=Solanum RepID=C5IH56_9SOLN Length = 106 Score = 48.2 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 15/29 (51%) Query: 3 ILLANPRGFCAGVDRAISIVENALAIYGA 31 + LA GFC GV+RA+ I A + Sbjct: 78 VKLAEAYGFCWGVERAVQIAYEARKQFPT 106 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.170 0.547 Lambda K H 0.267 0.0521 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,273,384,743 Number of Sequences: 3077464 Number of extensions: 112604799 Number of successful extensions: 327622 Number of sequences better than 1.0e-01: 163 Number of HSP's better than 0.1 without gapping: 459 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 325411 Number of HSP's gapped (non-prelim): 542 length of query: 316 length of database: 1,040,396,356 effective HSP length: 128 effective length of query: 188 effective length of database: 646,480,964 effective search space: 121538421232 effective search space used: 121538421232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 94 (40.5 bits)