BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (372 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=B... 620 e-176 UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cell... 323 8e-87 UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legione... 318 3e-85 UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechl... 296 5e-79 UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromob... 294 5e-78 UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobact... 259 8e-68 UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellul... 254 4e-66 UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actino... 207 4e-52 UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomy... 200 6e-50 UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovi... 195 3e-48 UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Le... 188 2e-46 UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeoba... 186 2e-45 UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Plancto... 185 3e-45 UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 183 8e-45 UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=C... 182 2e-44 UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bact... 176 9e-43 UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Maripro... 174 4e-42 UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya... 172 1e-41 UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synecho... 172 2e-41 UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia... 171 3e-41 UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinom... 170 1e-40 UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostoc... 167 5e-40 UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubro... 165 3e-39 UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium... 159 2e-37 UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actin... 159 2e-37 UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubro... 155 2e-36 UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterin... 155 2e-36 UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Coryneba... 155 3e-36 UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=P... 153 1e-35 UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=... 152 2e-35 UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomy... 152 2e-35 UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alph... 152 2e-35 UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp.... 149 1e-34 UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=C... 148 3e-34 UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinom... 142 1e-32 UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micr... 140 8e-32 UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Sacch... 137 8e-31 UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobact... 136 1e-30 UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangi... 136 1e-30 UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopir... 135 4e-30 UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 129 1e-28 UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Haloba... 129 2e-28 UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubro... 129 2e-28 UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 128 3e-28 UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=C... 127 8e-28 UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Strepto... 126 2e-27 UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 126 2e-27 UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=C... 124 8e-27 UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales R... 119 2e-25 UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineoco... 117 5e-25 UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=... 117 6e-25 UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 115 2e-24 UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax... 113 1e-23 UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseud... 112 3e-23 UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia... 111 4e-23 UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 110 6e-23 UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environ... 110 6e-23 UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp... 110 7e-23 UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actin... 108 3e-22 UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinom... 108 4e-22 UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=B... 107 5e-22 UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dass... 107 6e-22 UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=No... 107 6e-22 UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseud... 107 9e-22 UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xantho... 106 1e-21 UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actin... 105 3e-21 UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromono... 105 3e-21 UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromono... 105 3e-21 UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Myco... 104 6e-21 UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rh... 103 1e-20 UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax... 102 3e-20 UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 102 3e-20 UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alpha... 101 5e-20 UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 100 2e-19 UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 98 5e-19 UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salin... 97 7e-19 UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 97 8e-19 UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 97 9e-19 UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 97 1e-18 UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocar... 96 2e-18 UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromon... 95 4e-18 UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=A... 95 5e-18 UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocu... 94 6e-18 UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces Re... 94 6e-18 UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyc... 93 2e-17 UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Strepto... 88 6e-16 UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudo... 86 2e-15 UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphapr... 83 2e-14 UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthr... 81 6e-14 UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseu... 81 6e-14 UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylob... 80 1e-13 UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 77 9e-13 UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frank... 76 2e-12 UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenuli... 74 6e-12 UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Coryneb... 73 2e-11 UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenuli... 68 6e-10 UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanoc... 45 0.005 UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verru... 42 0.027 UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74... 42 0.037 UniRef50_B6KJV5 Gamma-glutamylcysteine synthetase, putative n=3 ... 42 0.039 UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilu... 42 0.053 >UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=Bacteria RepID=CAAL_ENT38 Length = 373 Score = 620 bits (1598), Expect = e-176, Method: Compositional matrix adjust. Identities = 286/370 (77%), Positives = 329/370 (88%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 MPLPDFH S+PFTLGIELE+QVVNPPGYDLSQDSS LI AVKN I AGEVKHDITESMLE Sbjct: 1 MPLPDFHSSDPFTLGIELELQVVNPPGYDLSQDSSALIAAVKNDIKAGEVKHDITESMLE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +AT VC++I+QAA QFSAMQ+ +L+AA D H++I GGGTHPFQKWQRQEVCD+ERY L Sbjct: 61 IATGVCQNIDQAAAQFSAMQQAILRAAGDQHIQIAGGGTHPFQKWQRQEVCDDERYNHNL 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E FGYLI QATVFGQHVHVGC +GDDAIYLLHGLSRFVPHFIALSA+SPYMQG+DT+FAS Sbjct: 121 ELFGYLILQATVFGQHVHVGCRNGDDAIYLLHGLSRFVPHFIALSASSPYMQGSDTKFAS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR NIFS FPDNG MPWVSNWQ FE LFR LSYT+MID+IKD+HWDIRPSPHFGTVEVRV Sbjct: 181 SRLNIFSGFPDNGKMPWVSNWQGFEGLFRRLSYTSMIDTIKDVHWDIRPSPHFGTVEVRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 MDTPLTL+HA+N+AGLIQATAHWLLTERP+KHQE+DYLLYKFNRFQACRYGL+G++TD + Sbjct: 241 MDTPLTLAHAINIAGLIQATAHWLLTERPYKHQEQDYLLYKFNRFQACRYGLDGLLTDVN 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG+++ + ED LL+++APSA K+G +SAI + + G +EAQ MRDF+ADGGSLI Sbjct: 301 TGEQKTIAEDMKWLLDRVAPSAEKLGGASAIAEIALMLKQGKSEAQRMRDFIADGGSLIS 360 Query: 361 LVKKHCEIWA 370 LV+KHCE+WA Sbjct: 361 LVQKHCELWA 370 >UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cellular organisms RepID=CAAL_POLNA Length = 381 Score = 323 bits (827), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 149/371 (40%), Positives = 230/371 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S +LG+ELEMQ+VN YDL+ + ++ + G V ++T SM+E Sbjct: 1 MSLEPFQKSSALSLGVELEMQLVNTHDYDLAPYAEDMLRLMSKIALPGAVVPEMTSSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 ++T +C + GQ + ++ ++++A ++ + GGGTHPFQ+W + + D R++ Sbjct: 61 VSTGICHSSAEVLGQLTQIRDALVKSADKLNIAVVGGGTHPFQQWHERRIYDKPRFRELS 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +GYL +Q T+FGQHVH+GC D A+ LH +SR++PHFIALSA+SPY+QG DT F S Sbjct: 121 ELYGYLSKQFTIFGQHVHIGCPDADTALLTLHRMSRYIPHFIALSASSPYVQGQDTAFDS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 +R N AFP +G P+ W +F F +++T ++ S+KD +WDIRP P FGT+E+RV Sbjct: 181 ARLNSVFAFPLSGRAPFALTWDEFTVYFNKMAHTGVVKSMKDFYWDIRPKPEFGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLT+ A +AG +Q+ W + ++PF E DYL+Y +NRFQACR+GL+ V DP Sbjct: 241 FDTPLTIERATALAGYVQSLGSWFMNDQPFMPTEDDYLVYTYNRFQACRFGLDAVYVDPA 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG PL E L + +I AH++ AS++I L V N+A+ +R+ + L Sbjct: 301 TGGHMPLREHILMTMAQIERHAHRLDASASIHLLRTSVERNDNDARWLRERQGEERLLAE 360 Query: 361 LVKKHCEIWAG 371 ++++ + + G Sbjct: 361 VIRQAADRFRG 371 >UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legionella RepID=CAAL_LEGPH Length = 383 Score = 318 bits (814), Expect = 3e-85, Method: Compositional matrix adjust. Identities = 145/372 (38%), Positives = 230/372 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S+ ++G ELE Q+++ L S L+ A+K+ ++K +IT+SM+E Sbjct: 1 MRLLSFKKSKIVSIGTELEFQIIDCSSLSLVSRSKELMRALKDMRYRDQIKPEITQSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + + + + + + +QK++++ A + CGGGTHPFQ+W Q++ ++R+++ Sbjct: 61 INSSIHQSAKEMYDELLELQKILVETAASIDIAFCGGGTHPFQQWTMQKIFPSKRFKKKF 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 + YL ++ATVFGQH+H+GC +GDDAIYL H L+R+VPHFIA+SA+SP+ G +T + S Sbjct: 121 NQYRYLSKRATVFGQHIHIGCPTGDDAIYLTHALARYVPHFIAISASSPFYLGINTNYCS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR IF+AFP +G +P++ NWQ+F +R + +I+++KD +WDIRP P GT+E+RV Sbjct: 181 SRSTIFNAFPLSGVIPYLRNWQEFSDYYRKMYRWKIIENMKDFYWDIRPKPELGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLTL ++ + IQA A +LL E+ + Y +Y +NRFQA R+GLEG +T Sbjct: 241 CDTPLTLRKSILITAYIQALALYLLEEKSVQLSHDLYYVYNYNRFQASRHGLEGELTVTD 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P+ +D L ++KI + +G S IE L+ V++ N++ L+ GS Sbjct: 301 KDRPIPIMDDILETIKKIEQYINGLGNSEYIEELYSDVINKQNDSVLINKIYKQDGSFSK 360 Query: 361 LVKKHCEIWAGD 372 LV CE+W D Sbjct: 361 LVAAQCELWLSD 372 >UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechloromonas aromatica RCB RepID=CAAL_DECAR Length = 384 Score = 296 bits (759), Expect = 5e-79, Method: Compositional matrix adjust. Identities = 144/362 (39%), Positives = 220/362 (60%) Query: 3 LPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 L DF S F+LG+ELE+Q+V+ +DL++ ++ L+ ++ GE+K +ITESM+E++ Sbjct: 6 LGDFKDSAAFSLGVELELQLVSKRDFDLTRGATDLLGSLDYDERFGEIKLEITESMIEIS 65 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 T ++ A S ++ + Q +++ ICGGGTHPF W + +C +R+ + Sbjct: 66 TQPQSTVDGIAADLSGLRDTLRQHCERNNIGICGGGTHPFHHWPERRICPGDRFNDLYQR 125 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 +GYL +Q TVFGQHVH+GC S D+AI+L +VP FIALSA+SP++ G D+ + S+R Sbjct: 126 YGYLAKQFTVFGQHVHIGCTSADEAIWLTQAFGVYVPAFIALSASSPFVDGVDSFYQSAR 185 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 N SAFP +G P + +WQ+F F L + SIKDL+WD+RP P FGTVE+RV D Sbjct: 186 LNAVSAFPLSGQCPPLGSWQEFTEHFAFLQACGIAQSIKDLYWDVRPKPEFGTVEIRVCD 245 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 TPLT+ A ++A L Q+ A WLL RP H K + ++N+FQACRYG E +I+DP Sbjct: 246 TPLTIEQATSLAALAQSLARWLLRTRPPLHTAKQAHVARYNKFQACRYGFEAMISDPVNL 305 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 + PL + LLE ++ A ++ + + L + V +A +R G+L +V Sbjct: 306 CQTPLKQTLADLLEAVSEDARELDCADWLSPLKQAVAENTGDAAWLRARENQHGNLNDVV 365 Query: 363 KK 364 ++ Sbjct: 366 RE 367 >UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromobacterium violaceum RepID=CAAL_CHRVO Length = 377 Score = 294 bits (752), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 143/370 (38%), Positives = 223/370 (60%), Gaps = 10/370 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 +F+ S+P TLG+ELE+ ++N Y+L++ S L+ + K ++K +IT+ M+E+ T Sbjct: 3 EFNQSQPLTLGVELELMILNRRDYNLTRGSDDLLLQINRKPHGYDIKPEITQGMIEIGTA 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V D+N + A++ +++ +A +L + GGG HPFQ W+ Q + ERY+ E +G Sbjct: 63 VHSDVNAMLDELLAIRTLLVDSAHKLNLGLAGGGAHPFQHWEDQRIYPKERYKLVSELYG 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 YL +Q TV+GQH+H+GC GD A+ L H L+R++PHFIALSA+SP+ QG DT F +SR Sbjct: 123 YLAKQFTVYGQHIHIGCPDGDAAVRLTHYLARYIPHFIALSASSPFYQGVDTSFQTSRLT 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +AFP +G MP V +W F A F + ++ S+KD +WDIRP P +GTVE+R+ DTP Sbjct: 183 SVNAFPLSGCMPVVDSWDAFNAYFERMEALGIVASMKDFYWDIRPKPEYGTVEIRICDTP 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKD-----YLLYKFNRFQACRYGLEGVITDP 299 L++ V +A Q +L R F+ D YL Y +NRFQACR+G +GV+ D Sbjct: 243 LSVETPVLLAAYAQ-----MLARRCFEESWNDICPEPYLTYSYNRFQACRFGFDGVMVDA 297 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 + + L ED L L + P A +G+ + AL ++ + ++++ +R GSL Sbjct: 298 RSKSQLGLQEDLLDTLRALEPHAEALGSQHQLAALRQRALKCHSDSRWLRQIFEQSGSLS 357 Query: 360 GLVKKHCEIW 369 +V++ E W Sbjct: 358 EVVRRQSEHW 367 >UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobacteriaceae RepID=D1RSS0_SEROD Length = 369 Score = 259 bits (663), Expect = 8e-68, Method: Compositional matrix adjust. Identities = 135/367 (36%), Positives = 209/367 (56%), Gaps = 7/367 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M LP F SE TLG E+E+Q+V+ YDLS + +++ V +K +KH++T+SM+E Sbjct: 1 MSLP-FKCSERLTLGTEIELQLVDNDSYDLSHKADRVVEDVDDK---KRIKHELTKSMVE 56 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L + V DI + + + + + +A ++CGGG H W++Q + D+ERY Sbjct: 57 LNSSVHTDIGELLAELNELTGKIRASAQRIDCDVCGGGRHLSNDWRQQVITDSERYTLLA 116 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 FGYL + A VFGQH+H+G GD+A+YL H ++ ++PH IALSA+SP QG DT FAS Sbjct: 117 SRFGYLSKLACVFGQHIHIGVNDGDEAMYLCHAMTPYLPHLIALSASSPLYQGVDTLFAS 176 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR + ++FP+ G + + NW +F + L+ +I+ IKD++WD+RP P GTVEVRV Sbjct: 177 SRFSAQNSFPNYGCLEQIYNWDEFTVYYERLTSAGVIEGIKDIYWDVRPKPELGTVEVRV 236 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY-KFNRFQACRYGLEGVITDP 299 DTPL + HA +AG + A +LL R + +Y+ + +N+ ACR+G DP Sbjct: 237 CDTPLHIHHAATLAGYCRLLARYLLDNR--QRVIAEYVAFTNYNKINACRHGFGADYVDP 294 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 T R LT L L + P ++ ++ + V LN+A +R +G Sbjct: 295 ATLRRCSLTSHMLATLAALRPGVQNSEENALLDGVEHYVKIALNDADRIRRLRHNGLQQK 354 Query: 360 GLVKKHC 366 ++K+ C Sbjct: 355 EVIKQLC 361 >UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellular organisms RepID=CAAL_BORPD Length = 415 Score = 254 bits (649), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 148/368 (40%), Positives = 212/368 (57%), Gaps = 4/368 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F S P TLGIELE+Q++NP +DL+ + L+ + N A VK +IT SM+EL + V Sbjct: 6 FVSSAPNTLGIELELQLINPRSFDLAAAADELLAQMANHPIADRVKPEITRSMIELNSSV 65 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + M+ + AA + + GGG HPF +WQ + + D+ R+Q E +GY Sbjct: 66 HEHPMGLLAEMREMRDALCDAADAVGVSVAGGGAHPFMRWQERAISDSPRFQYLAEMYGY 125 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L +Q TVFGQH+H+G SGD A+ ++ GLS +VPHFIALSA+SPY +G DT F+ R N Sbjct: 126 LARQFTVFGQHIHLGVPSGDAAVRMVRGLSPYVPHFIALSASSPYYEGVDTLFSCCRLNA 185 Query: 186 FSAFPDNGPMPW-VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 S+FP G +P V++W +FEA L + +SIKDL+WDIRP P FGTVE+RV DTP Sbjct: 186 VSSFPLAGHLPADVTDWYRFEAHIAQLRACGLAESIKDLYWDIRPKPEFGTVEIRVCDTP 245 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 LT+ A +A QA A +L R + +L Y+ N FQACR+GL+G P G R Sbjct: 246 LTVERACQLAAFAQALA--VLVTREPEPAPAAWLAYRSNHFQACRFGLQGSYVTP-DGQR 302 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 L + L +++ P A ++G + AL + + N+A+ +R L +V+ Sbjct: 303 LRLIDHLRALFQRLMPIADELGTGDMLVALRDESIRNGNDARWLRSQFHRLRDLPLVVES 362 Query: 365 HCEIWAGD 372 W G+ Sbjct: 363 MTHAWRGE 370 >UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actinomycetales RepID=CAAL_THEFY Length = 399 Score = 207 bits (528), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 117/364 (32%), Positives = 193/364 (53%), Gaps = 8/364 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE----VKHDITESMLE 60 +F+ S+ TLG+E E+Q+V+ L QD+ L++ + +++ E ++H++ +S +E Sbjct: 4 EFNPSKRATLGVEWELQLVDRDSGHLRQDAQKLLEELP-ELSGAESNPPLRHELMQSTIE 62 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + T +C +++ SA + QAA +E+ GTHP W+ QE ++RY + Sbjct: 63 VVTGICETVDEVKEDLSATVARLTQAADGRGIELACAGTHPIDDWRDQEFAPSQRYSELI 122 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +L ++ FG HVHVG D I +++ LSR++PHF+AL+A+SP+ G DT AS Sbjct: 123 EQMQWLARRILTFGVHVHVGVTDRDKVIPIVNALSRYLPHFLALTASSPFWSGHDTGLAS 182 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR +F A P GP P +++W FE L I SIK++ WDIRP P FGTVE+R+ Sbjct: 183 SRSIVFGALPTAGPPPRLAHWGAFEEYMDTLLRAGTITSIKEVWWDIRPHPEFGTVEIRM 242 Query: 241 MDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 D T+ A L Q+ +R ++ + N+++A RYGL+ I Sbjct: 243 FDGIPTVREVGMAAALSQSLVQLFEQQLDRGYRLPSPSSWVVTDNKWRATRYGLDARIII 302 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 G PL +D LL ++ P A ++G + ++ + + G + + R + GG L Sbjct: 303 DERGSTVPLRDDLYELLHELRPIAERLGCAEDLDVVAEILHYGAS-YERQRAIIRQGGVL 361 Query: 359 IGLV 362 +V Sbjct: 362 KDVV 365 >UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomycetales RepID=D2SG64_9ACTO Length = 401 Score = 200 bits (509), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 115/366 (31%), Positives = 193/366 (52%), Gaps = 5/366 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG--EVKHDITESM 58 M +P F SE +LG+E E+Q+V+ L+ + +++ ++ + + KH++ +S Sbjct: 1 MQIP-FRSSERASLGVEWELQLVDVRTRQLTAGAVEILEELRPEGAEEHPKAKHELLQST 59 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E+ T VC + +A + V AA L + GTHP WQ Q++ ERY + Sbjct: 60 VEVITGVCTTVAEAKADLAGTVAEVRAAAERRGLGLMCAGTHPITDWQTQQISPKERYLQ 119 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E +L ++ +FG HVHVG + + AI +++ L+++VPHF+ALSA+SP+ G DT Sbjct: 120 LVEKMQWLARRLQIFGVHVHVGVRAPEKAIPIVNALTQYVPHFLALSASSPFWVGCDTGL 179 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G +S W +FE L T I+S++++ WDIRP P FGTVE+ Sbjct: 180 ASARSKVFEGMPTAGLPYQLSGWDRFEEYMETLISTHAIESVREVWWDIRPHPDFGTVEL 239 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 R+ D TL +A L Q T+ R + + + N+++A RYGL+ I Sbjct: 240 RICDGLPTLDEIGAVAALSQCLVEQFDTQLDRGYTLPVPASWVLQENKWRAARYGLDADI 299 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 G RP+ + L+E++ P+A ++G + + +HR + G + + A G Sbjct: 300 VVDDKGTVRPVRQAITDLVEELEPTARRLGCEAELADVHRILAVGASYQRQRAVAAASDG 359 Query: 357 SLIGLV 362 L +V Sbjct: 360 DLTAVV 365 >UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovibrio bacteriovorus RepID=CAAL_BDEBA Length = 378 Score = 195 bits (495), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 109/373 (29%), Positives = 201/373 (53%), Gaps = 6/373 (1%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P+P F S+ F+LG+E+E+Q+++P +L S +++ + + + +K ++ +SMLE+ Sbjct: 6 PIP-FGKSDLFSLGVEVELQIIHPETRNLFPISPDILE--EWSLQSPHLKPEVFQSMLEI 62 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C+++ + + + +L+ H + GTHPF KW + ++RY+ LE Sbjct: 63 DTPICKNVQEVEYELLLTSRELLRICKKHGARLASNGTHPFAKWHHRIFYPSDRYEYLLE 122 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 ++ ++ ++G HVH+G GD I +++ ++PH +A+SA+SP+ G DT ASS Sbjct: 123 RNQHIARRLMIYGLHVHLGMKDGDHCIAMMNEFLYYLPHMLAMSASSPFWTGHDTGLASS 182 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F A P G V NW QFE + + L+ + I S KD+ WDIRPSP++GT+E+R+ Sbjct: 183 RITVFEAHPAGGTPCRVENWAQFEDIVQKLTRSNSIGSFKDIWWDIRPSPNYGTLEIRIC 242 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D + + I A L E+ + Q D + + N+++A R+GL+ + Sbjct: 243 DGVPGIRKTTRLVAFIHLLAKHLQKRLEQGIRRQTPDDWMVRENKWRASRHGLDCEVLID 302 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 + G + L ED LL + A ++G + ++ L + ++ + ++ R GSL Sbjct: 303 NDGMTKNLREDIKDLLAAMKEDAAEMGYTEYLKQLVEEDLTHPS-YEIQRALFEKTGSLE 361 Query: 360 GLVKKHCEIWAGD 372 +V C+++ D Sbjct: 362 HVVDSLCDVFEKD 374 >UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Legionella RepID=D1RC58_LEGLO Length = 402 Score = 188 bits (478), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 104/351 (29%), Positives = 180/351 (51%), Gaps = 5/351 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F+ TLG+E+E+Q+++ Y+L + ++ A+ + ++K + S +E+ T+ Sbjct: 27 FNSGGVLTLGVEIELQLIDAETYNLCSRAEDILAAMSH---LEKIKPEFYLSTIEVNTNK 83 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C + + A + + + + G+HPF K+ E+ RY ++ + Sbjct: 84 CGSVQEVEDDLYATLFELQHVSKKLGILLSTTGSHPFSKYCDWEISPTARYLDLIDRNQW 143 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L ++ +V+G HVH+G +SG++ I + F+PH +ALS++SP+ QG DT AS RP Sbjct: 144 LTRRMSVYGLHVHLGMSSGEECIRFNNFFMYFLPHLLALSSSSPFWQGIDTGLASCRPTT 203 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 + A P G V +WQ FE L++ L I S+KDL WD+RPSP+FGT+E+RV D Sbjct: 204 YEALPTAGQPYHVRSWQDFEHLYKTLKSCGSIKSLKDLWWDLRPSPNFGTLEIRVCDGTA 263 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEK--DYLLYKFNRFQACRYGLEGVITDPHTGD 303 TL+ + + LI A AHW + Y L + N+++A RYGL+ + G Sbjct: 264 TLAETLALVALIHALAHWFADNGSWLESVAYPPYWLSRENKWRAIRYGLDAELVMNTEGK 323 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD 354 + + ED +EK+ P ++ + L + SG + + + F + Sbjct: 324 IKLMREDINEWIEKLKPYIEQLNYQTYFATLQSIMSSGTSTERQRKVFTYN 374 >UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeobacter violaceus RepID=CAAL_GLOVI Length = 372 Score = 186 bits (471), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 106/367 (28%), Positives = 190/367 (51%), Gaps = 9/367 (2%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG-EVKHDITESML 59 M +P F S TLG+E+E+Q+++P +L+ L+ + G VK ++ ++ + Sbjct: 1 MTIP-FQSSTAPTLGVEMELQIIDPATGNLTPRGPELVTFCEEHPEVGLVVKPELVQATI 59 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E+ T +C+D+ Q + ++ + + GTHPF +W+ + RY+ Sbjct: 60 EINTGICKDVAQVERDLTTQLTLLRSVCRERGVSFLSAGTHPFARWRERRYTQTPRYRAL 119 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 ++ + ++ ++G HVHVG GD AI +++ ++++ P +ALSA SP+ +G DT Sbjct: 120 VDKHVWTARRMQIYGLHVHVGMPDGDTAIQVINQITQYAPMLLALSANSPFWEGDDTGLD 179 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R +F G NW+ +E L L T I S +++ WDIRP FGT+EVR Sbjct: 180 SCRTKVFENLSSAGLPFRFENWEGYENLINVLLETGSIGSQREIWWDIRPHSDFGTIEVR 239 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY----KFNRFQACRYGLEGV 295 + D TL+ + + L+Q A + R +++ E+ LL+ + N+++ACR+GLEG Sbjct: 240 ICDATRTLAEVLALTALVQCLAVYF--RRLYENGEEIRLLHPGIIRENKWRACRWGLEGE 297 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + DP T P + + + ++ A ++G S+ + A+ + SG N A R + Sbjct: 298 LIDPLTLKGVPTRKLIEQTVGEMQSLAAELGCSAYLAAIPAILASG-NGATRQRRIYSQS 356 Query: 356 GSLIGLV 362 SL+ +V Sbjct: 357 RSLVAVV 363 >UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Planctomycetaceae RepID=A3ZKZ3_9PLAN Length = 378 Score = 185 bits (469), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 102/324 (31%), Positives = 169/324 (52%), Gaps = 3/324 (0%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F ++ FT+GIELE+ +V+ LS L+DA ++ A +K ++ + LE+ T++ Sbjct: 6 FTSNDAFTVGIELELGLVDSQTMALSSSVQRLLDAAPAEL-ASRIKPELMQCCLEINTEI 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C I +A V D L + G THPF W Q+V NERY ++ Sbjct: 65 CTTIEEAESDLRRKLLAVQGLTDDLGLRLWWGSTHPFSHWCDQKVTQNERYLNLVDLLQE 124 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++ G HVHVG SGD A+ + + +++P +ALS +SPY +G DT AS R I Sbjct: 125 MARRLVTNGLHVHVGVESGDKAVMICDRIMQYLPLLLALSTSSPYWEGRDTGLASHRSKI 184 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 P G P + NW ++ L + T I++I+++ WD+RP +FGTVEVRV D P Sbjct: 185 MEGLPTAGLPPLMRNWSEYVWLVNHMVDTGFINTIREIWWDVRPHHNFGTVEVRVCDMPG 244 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVITDPHTGD 303 L A+ ++ +IQ L E + D ++ + N+++ACR+G + + + +T Sbjct: 245 NLEDAMTISAMIQCLVKQLSDEIDHGAYQHDCHPMMVRQNKWRACRFGSDAKLVNSYTYQ 304 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGA 327 ++ RL+E++ A ++G Sbjct: 305 VESVSTVVARLVERLMAPAIELGC 328 >UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0L2A3_GORB4 Length = 379 Score = 183 bits (465), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 114/370 (30%), Positives = 183/370 (49%), Gaps = 13/370 (3%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--AGEVKHDITESM 58 +P F S +LG+E E + + DLS ++ L AV+ + AG+V ++ + Sbjct: 4 IPSIPFRGSPTPSLGVEWEFALTDKQSGDLSNSAAALFAAVEQRHPEHAGQVHKELLRNT 63 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +EL T VCR +A S VV A + +++ G GTHPF +W Q + + RY Sbjct: 64 VELVTGVCRTTAEALDDLSGTLGVVRGIADELGVDLYGAGTHPFAEWSTQLLTEGHRYAE 123 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E + +Q ++G HVHVG + D + +L L + PH +A+SA+SP G DT + Sbjct: 124 LIERTQWWGRQMLIWGVHVHVGISHRDKVLPILDALLNYYPHLLAISASSPMWAGQDTGY 183 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G + W +FE+ T +ID + ++ WDIRPSPH GT+EV Sbjct: 184 ASNRAMMFQQLPTAGLPFQFARWDEFESFVADQKTTGIIDHLNEIRWDIRPSPHLGTIEV 243 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYL------LYKFNRFQACRYGL 292 RV D L LI H L+ + + + + L L + N+++A RYGL Sbjct: 244 RVCDGMTNLRELSAAVALI----HCLVVDLDRRLEAGETLPTMAPWLVQENKWRAARYGL 299 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + ++ R +TED +L+++AP A + + + + SG Q R Sbjct: 300 DAIVITDGNCAERLVTEDLAGVLDRLAPIARDLDCIDELAGVTSIIESG-GSYQRQRAVH 358 Query: 353 ADGGSLIGLV 362 A GG++ +V Sbjct: 359 AGGGTMRDVV 368 >UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C317D2 Length = 366 Score = 182 bits (461), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 104/330 (31%), Positives = 174/330 (52%), Gaps = 16/330 (4%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 +T+GIE E+ +++ +L+ I+ + T+ +VK ++ ES+LE+AT D Sbjct: 10 YTIGIEEELMILDAESLELAN----AIEGMLEDSTSDQVKPELMESVLEIATSPQPDAAA 65 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A + +++ V + A L I GTHPF W+ Q + RY+ + + ++ +Q Sbjct: 66 AGEELRDLRRQVRETAASRGLAIGSAGTHPFAMWEEQRIVGRTRYRDLVSDLKFVARQEI 125 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 +FGQHVHVG D AI++ +G+ +P +ALSA SP+ + T AS+R IF AFP Sbjct: 126 IFGQHVHVGLDDADKAIHVANGMRIHLPVLLALSANSPFWRADATGLASTRTPIFRAFPR 185 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P +W + A + + +I+ L +D+RP P+ GTVE+RVMD+ + H + Sbjct: 186 VGIPPTYDDWDDYAAKIGFMVESRVIEDYTYLWYDVRPHPNLGTVEIRVMDSQTRVEHTL 245 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKF-------NRFQACRYGLEGVITDPHTGDR 304 A LIQA L +H E L K+ N++ A R+GL+G + D + +R Sbjct: 246 AFAALIQAMVKELA-----EHFEAGKRLSKYPHQMIDENKWLAARHGLDGELVDLPSTER 300 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 E RLL+++ A +G+++ +E + Sbjct: 301 VRTRELAHRLLDRLRDHAQDLGSAAELEGI 330 >UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bacteria RepID=CAAL_CHLAA Length = 390 Score = 176 bits (447), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 105/344 (30%), Positives = 175/344 (50%), Gaps = 7/344 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 FTLGIE E Q+V+P +L + +++ + I ++K ++ +S++E+ T CR I++ Sbjct: 13 FTLGIEEEYQIVDPETRELRSYITQILEPGRT-ILREQIKPEMHQSIVEVGTRPCRTISE 71 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A + ++ + A H+L I GTHPF W +QE+ +ERY + Q Sbjct: 72 ARAEIVRLRSAIAGLAARHNLRIVAAGTHPFSSWMQQEITPDERYHMVVGEMQDAALQLL 131 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 +FG H H+G + + AI L++ PH +ALS +SP+ G +T F S R IFS FP Sbjct: 132 IFGMHCHIGMPNNEVAIELMNVARYICPHLLALSTSSPFWMGRNTGFKSYRSVIFSTFPR 191 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P + +FE + L T ID+ K + WD+RP P FGT+E RV D + + Sbjct: 192 TGIPPTFHSASEFERYVQLLVNTGCIDNGKKIWWDLRPHPFFGTLEFRVCDIATKVEECL 251 Query: 252 NMAGLIQA--TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A +QA + + E + L N+++A R+GL+G + D G R+ + Sbjct: 252 ALAATMQALIVKFYTMFEENTTFRVYRRALINENKWRAQRWGLDGKLID--FGKRKEVEA 309 Query: 310 DTL--RLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDF 351 L ++E + +G+ +E L + V +G + + +R F Sbjct: 310 KALVHEIVELVDDVVDMLGSRREVEYLLKIVENGTSADRQLRVF 353 >UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0F2E7_9PROT Length = 371 Score = 174 bits (442), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 99/306 (32%), Positives = 156/306 (50%), Gaps = 9/306 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F S P TLG+E+E V+ + + + +K ++ S +E+ TD+ Sbjct: 10 FQDSSPGTLGVEMEWMTVD---INSGEQVPAAPAVFAAVGESARIKPELFTSTVEINTDI 66 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 R + A + A+ V Q H + GTHP W+ Q+V D++RY R LE + Sbjct: 67 HRSTSAAVDELQALYDQVSQILGGQHAALLSAGTHPTSHWRDQQVTDDQRYARLLERLQW 126 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 ++++ +FG HVH+G GD I ++ L +P F+A+SA SP+ QG DT ++SR + Sbjct: 127 MVRRFNIFGIHVHIGMPDGDTCIRAMNHLLPIMPVFLAISANSPFWQGEDTGLSASRIKV 186 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 F G + NW+ FE L T IDS++D+ W++RP P FGT+EVR+ D P Sbjct: 187 FEGLSQGGMPFYFENWRDFEHCAGRLQATDSIDSVRDIWWEMRPHPDFGTLEVRIGDMPG 246 Query: 246 TLSHAVNMAGLIQATAHWLL-TER-PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 + + ++A A + TE P H L + NR++ACRYG+ G + DP T Sbjct: 247 SRADTQAYIAYVRAEAMAAMHTEAVPRVHPS----LIRENRWRACRYGMHGTMIDPFTER 302 Query: 304 RRPLTE 309 P+ + Sbjct: 303 LMPVLD 308 >UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YLQ7_9CYAN Length = 371 Score = 172 bits (437), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 102/359 (28%), Positives = 177/359 (49%), Gaps = 10/359 (2%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 E TLG+E E Q+++P LS +I + V+ ++ +S +E+AT VC+ + Sbjct: 5 EGLTLGVEEEYQIIDPKTRQLSGRGEKIISFAEENYGKEIVQPEMHKSQIEIATSVCKSL 64 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + + S +++V++AA + I THPF W++QE N RYQ+ + + ++++ Sbjct: 65 AEVRSELSEARRIVIEAAQRDNKAIAAAATHPFSHWKQQETTANFRYQKLEQEYQQILRE 124 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 FG HVHVG + AI +++ ++ +ALSA SP+ G T + S R ++S F Sbjct: 125 LVTFGCHVHVGIEDKEVAIAVINRARMWLSVLLALSANSPFWLGKKTGYISYRTELWSPF 184 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G P +++ ++ L +I ++W+IR S H+ T+E RV D LT+ Sbjct: 185 PLFGSPPVFEDYKAYQNFVEQLIKMEVIQDTTTIYWNIRISEHYPTIEFRVSDICLTVDE 244 Query: 250 AVNMAGLIQATAHWLLTERP------FKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 AV +AGL++ L E F H E L K + A RYGL+G + D Sbjct: 245 AVMIAGLVRGLVQTCLIEIENDFPLIFVHPE----LLKTADWYAARYGLQGKLIDVMQQR 300 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 +P + + L + P+ +G + +L +V+ N AQ + G+++ +V Sbjct: 301 SKPAKDLVKQFLNYVRPALESLGDWEEVSSLVDKVLKHGNAAQRQLEIYQRQGNIVEVV 359 >UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WGF8_9SYNE Length = 377 Score = 172 bits (435), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 104/355 (29%), Positives = 173/355 (48%), Gaps = 6/355 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 FT+G+E E Q+V+P L+ S LI +N T E+ H++ +E+AT +C ++ Sbjct: 5 FTIGVEEEYQIVDPETRSLADCSKSLIKTNQNSNTEQEIVHELFRCEVEIATGICHTLDD 64 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + V++AA D+ I GTHPF W+ QEV ERY E+ +I++ Sbjct: 65 VRRALVQARTAVIEAAQDNGAVIAAAGTHPFSPWEEQEVTPKERYYALQEDLQQIIKELI 124 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G HVHVG + A+ + + ++P ++L+A SP+ G DT + S R ++ P Sbjct: 125 ILGCHVHVGVEDREMAVQISNRARIWLPLLLSLTANSPFCDGKDTGYDSYRMALWCRLPT 184 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P+ N+ ++ + L T + D ++WDIR S F T+E R+ D ++ AV Sbjct: 185 AGPPPFFENYADYQGFIQKLIDTDITDDPTKVYWDIRLSERFPTIEFRMSDVCASIEEAV 244 Query: 252 NMAGLIQATAHW----LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 +AG+I+A A+ ++ +P + L K +QA R+GL G + D T + P Sbjct: 245 MLAGIIRALAYTCYQDVINGQPALPVRGEML--KAAMWQAARHGLSGELIDFATTESVPA 302 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 + I P G + ++ +++S N AQ R SL +V Sbjct: 303 KTLVQSFMRYIQPGLAHFGDEAIVKKEVDKILSEGNSAQRQRAVYEKTSSLESVV 357 >UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia mucilaginosa RepID=D2NRT8_9MICC Length = 394 Score = 171 bits (434), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 103/366 (28%), Positives = 168/366 (45%), Gaps = 15/366 (4%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNK--------ITAGEVKHDITE 56 DF S TLG+E E+ +++ +L+Q + ++ ++ + V + E Sbjct: 15 DFASSPQSTLGVEWEIALIDRESGELTQRAGEVLSILRERRPELLEPASDRAHVTGEFLE 74 Query: 57 SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY 116 + +E+ T +C + +A Q + ++ + D +E GTHPF W Q V ERY Sbjct: 75 NTIEVVTGICHTVAEACRQLQELTDIIREITDDLGIEFYPAGTHPFSHWADQPVVAKERY 134 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 QR +E Y + ++G HVHVG S D + L+ L+ + PH +ALS +SPY G DT Sbjct: 135 QRVVERAQYWGRHMVIYGVHVHVGVDSRDKVLPLIDALTNYGPHLLALSCSSPYWDGIDT 194 Query: 177 RFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTV 236 +AS R ++ P NG W+Q+ L T +I+ + WD+RP P +GT+ Sbjct: 195 GYASHRTQLYQQLPTNGLPFHFDTWEQYSEYLDSLVATDVINDPSEDRWDVRPVPRYGTI 254 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF----NRFQACRYGL 292 E+R D +L + Q + R + E +L + N+++ RYGL Sbjct: 255 EMRYCDGLASLPDVAAIVAFTQCLVEYF--SRQVEAGESIEVLAPWHAQENKWRVARYGL 312 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + I + ++R L ED LL K+ P A + + + R + G A R Sbjct: 313 DAKIVVSNAPEQRTLREDFELLLPKLEPVARDLDCEVELAQVRRILAEGTG-ADRQRAVF 371 Query: 353 ADGGSL 358 GSL Sbjct: 372 EKTGSL 377 >UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinomycetales RepID=CAAL_CLAMS Length = 383 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 103/366 (28%), Positives = 183/366 (50%), Gaps = 3/366 (0%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF P +GIE E+ V+ +L+ + ++ + + V + + +E+ + Sbjct: 10 DFARQPPSRVGIEWELACVDRGSGELAGVAPQILRSFPHDDAHPHVTGEFLTNTVEVVSA 69 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC-DNERYQRTLENF 123 + A + + + V+ A +++ GTHPF W Q+V DNERY L+ Sbjct: 70 PHSRVGHAVDDLARLIERVVDVADPLGIDLMCAGTHPFSAWPDQDVTPDNERYATLLDRT 129 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 + +Q ++G HVHVG G A+ +L+ L +P F ALSA+SP+ G +T +AS+R Sbjct: 130 RWWGRQMMIWGVHVHVGIEDGSKALPILNALLVHLPRFQALSASSPFWSGQETGYASNRA 189 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 +F P G P ++ W +E L +++ +ID +L WDIRP+P +GT+E RV D Sbjct: 190 LMFQQLPTAGLPPDLTTWADYERLIGDMTHVGVIDHHSELRWDIRPAPKWGTLETRVFDG 249 Query: 244 PLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 TL ++A L+Q H L +R + + N+++A RYG++ +I Sbjct: 250 VSTLGEIASLAALVQCLVHDLSAALDRGEELPRMQPWFVRENKWRAARYGMDAIIIQDAA 309 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 G+ + +DT L+E+++P+A +G + + + V G + + +R + G+L + Sbjct: 310 GEEALVGDDTRALVERLSPTADALGCEAELRGILDIVDRGASYQRQLRVAEENDGALAPV 369 Query: 362 VKKHCE 367 V E Sbjct: 370 VTHLVE 375 >UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostocaceae RepID=CAAL_ANAVT Length = 387 Score = 167 bits (424), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 109/375 (29%), Positives = 175/375 (46%), Gaps = 45/375 (12%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE----VKHDITESMLE 60 +F S F+LG+E+E+Q++NP D+ L+D + + ++ + ++M+E Sbjct: 5 EFKSSPEFSLGMEIELQLLNP-------DTLQLVDGISPLLAQTPENSWIQPEFNQAMVE 57 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN------- 113 +A+ VC +I + A+ + + + IC GT+P CD Sbjct: 58 IASQVCSNIPELEANIVAILRDLKTRCQALGMTICTAGTYP--------CCDRFASITPI 109 Query: 114 ERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQG 173 RY GYL +HVG SGD AI ++ L ++P +ALSA+SP+ G Sbjct: 110 PRYLSQQNTSGYLADLMMTCALQLHVGMPSGDVAIDIMGRLKPYLPILLALSASSPFWWG 169 Query: 174 TDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHF 233 DT FAS R S+ G P NWQ F F M + I+D+HWD+RP P F Sbjct: 170 HDTSFASFRQRFLSSMRTYGICPTFKNWQDFTNFFATAQNAGMFEIIRDIHWDLRPQPDF 229 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQA------------TAHWLLTERPFKHQEKDYLLYK 281 GT+EVRVMD T+ ++ +A I + +LLT P +L+ + Sbjct: 230 GTLEVRVMDAQPTIKESMMLAAFIHSLIVDMYHHSQGKQTEFLLTPLP-------WLIER 282 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 N F+A R+GL+ + G+ RP+ +L +A +A +G SS + L +++ G Sbjct: 283 ENYFRASRWGLDANYIEDEQGNSRPIRNIVKDILNVLAETADTLGNSSYLFQLEKRLDQG 342 Query: 342 LNEAQLMRDFVADGG 356 + + R F + G Sbjct: 343 ASYIRQRRVFESTGS 357 >UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL1_RUBXD Length = 376 Score = 165 bits (417), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 102/353 (28%), Positives = 172/353 (48%), Gaps = 6/353 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 +TLG+E E+ +V+ +L ++ + + A V +++ +S+LE+ T VCR + + Sbjct: 12 YTLGVEEELCIVDASTGELVPKIEEIMSRLPEDL-AEAVSYELFQSVLEIKTPVCRTVGE 70 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A ++ V + GTHPF +++ Q+V ++ERY++ +E ++ + Sbjct: 71 AERVLRELRGRVGSWTAACGASLASAGTHPFSRYRDQKVTEHERYRQVIEELRWVATREV 130 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 +FGQHVHV ++AI + L+ P +ALSA SPY QG DT F SSR IF FP Sbjct: 131 IFGQHVHVAVPGPEEAIQAHNRLAEQAPLLLALSANSPYWQGMDTGFESSRVQIFETFPR 190 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P + FEA + +D WD+RP P GT+E+RV+D+ L HAV Sbjct: 191 AGMPPAFPEYAAFEAYVDLMVECGAMDDYTFCWWDVRPHPKLGTIELRVLDSQTHLRHAV 250 Query: 252 NMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + L Q L + P +D L N+++A R GL+ D P + Sbjct: 251 ALTALTQCIVASSLEDEDAPKGPYHRDIALE--NKWRASRRGLDAAFFDVDERRNVPARD 308 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 +E++ P A ++G + + ++V G + ++ R+ G + +V Sbjct: 309 LARAAVERLRPHAQQLGCEEELLGVL-EIVEGGSGSRRQREIYEKSGDFLDVV 360 >UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium genitalium ATCC 33030 RepID=C8NYP5_9CORY Length = 395 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/336 (28%), Positives = 165/336 (49%), Gaps = 20/336 (5%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P DF+ SE +LG+E E+ V++P DL +I AV ++ ++ + ++ +EL Sbjct: 25 PFRDFNRSEGPSLGVEWEIGVIDPATRDLVARGPEVIQAVNDRWPDVHLEKEFLQNTVEL 84 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T VCR+ +A A + + + +L++ G HPF ++ Q V D YQ + Sbjct: 85 VTPVCRNTAEAIEYLRATKDKIQAVTDEKNLQLWASGGHPFSDFREQAVGDKPTYQEIVN 144 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y QQ ++G HVHVG + +++ + PH +A+SAASP +G DT +AS+ Sbjct: 145 RTQYWGQQMLLWGTHVHVGIRHEERVWPIINAIMTKYPHLLAVSAASPAWEGLDTGYASN 204 Query: 182 RPNIFSAFPDNGPMPW-VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R ++ P G MP+ NW ++ R + + + +H+D+RP+ +GT+EVR+ Sbjct: 205 RTMLYQQLPTAG-MPYQFQNWSEWVQFMRDQTTSGVTSHTGSMHFDVRPAAKWGTIEVRI 263 Query: 241 MDTPLTLSHAVNMAGLIQA-TAHW---------LLTERPFKHQEKDYLLYKFNRFQACRY 290 D TL + L H+ L T +P+ E N+++ RY Sbjct: 264 SDASPTLRELAAVVALTHCLVVHYDAMLDDGRDLPTLQPWHVAE--------NKWRGARY 315 Query: 291 GLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG 326 GLE + D R +T++ ++E++ P A ++G Sbjct: 316 GLEAEVITSRATDERLVTDELYDMVEELQPVAQRLG 351 >UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actinomycetales RepID=CAAL_MYCUA Length = 392 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/340 (28%), Positives = 160/340 (47%), Gaps = 21/340 (6%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF S T+G+E E +V+ DLS +++ +I + V ++ + +E+ + Sbjct: 27 DFARSPRPTVGVEWEFALVDAETRDLSNEATAVIAEIGEN---PRVHKELLRNTVEVVSG 83 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 VC +A + +E+ GTHPF +W Q++ D RY ++ Sbjct: 84 VCGSAGEAIEDLRTTLGPARRIVHARGMELFCEGTHPFAQWSTQKLTDAPRYAELIKRTQ 143 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 + +Q ++G HVHVG +S + + ++ L + PH +ALSA+SP+ G DT +AS+R Sbjct: 144 WWGRQMLIWGVHVHVGVSSANKVMPIISALLNYYPHLLALSASSPWWGGEDTGYASNRAM 203 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +F P G W +FE T +ID I ++ WDIRPSPH GT+E+R+ D Sbjct: 204 MFQQLPTAGLPFQFQTWSEFEGFVYDQKKTGIIDHINEIRWDIRPSPHLGTIELRICDGV 263 Query: 245 LTLSHAVNMAGLIQA----------TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 L + L+ L T P+ QE N+++A RYGL+ Sbjct: 264 SNLRELGALVALMHCLVVDLDRRLDAGETLPTMPPWHVQE--------NKWRAARYGLDA 315 Query: 295 VITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 VI + R +T+D +L ++ P A + + + A+ Sbjct: 316 VIILDAESNERLVTDDLDDVLTRLEPVARSLSCADELAAV 355 >UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL2_RUBXD Length = 363 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 106/364 (29%), Positives = 175/364 (48%), Gaps = 20/364 (5%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F S P+T+G+E E Q+++P L+ ++ A ++ G + +++ S LE+ T Sbjct: 5 FGASPPYTVGVEEEFQLIDPRTRALTPKIEEVLAAGDGELPEGTLASELSASCLEVRTPA 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + + A A++ V + A + G HPF Q + RY++ E G+ Sbjct: 65 YASVAELARALPALRARVRRLAERSGARLVSAGAHPFSPAAEQPITGKPRYRKVDEEMGW 124 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++G HVHV G++A+ + L+R VP FIALSA SP+ +G DTR AS R + Sbjct: 125 PARMQAIYGLHVHVAVPGGEEAVRAVSALARHVPLFIALSANSPFWEGRDTRLASVRAKV 184 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLH---WDIRPSPHFGTVEVRVMD 242 F P +G P ++W++F R + SI+D WD+RP P GTVE+R D Sbjct: 185 FGLIPRSGLPPRFASWEEF---VRHVERLVRAGSIRDYTFCWWDVRPHPKLGTVELRAPD 241 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 +A L Q A + +D LL + N+++A R+GLE + D +G Sbjct: 242 AQTDPGRTAALAALCQCLAAAAEE-----FEPEDPLLTEENKWRATRHGLEAELYD-FSG 295 Query: 303 DR----RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 R R E+ L+ ++ P A ++G + +E + ++ A R +A GSL Sbjct: 296 QRTVAARRAAEE---LVGRLLPVARELGCEAELEGVL-EISRSATGADRQRAVLAREGSL 351 Query: 359 IGLV 362 +V Sbjct: 352 KSVV 355 >UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterineae RepID=C2CS07_CORST Length = 381 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 96/371 (25%), Positives = 179/371 (48%), Gaps = 9/371 (2%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P F S TLG+E E+ +V+P +DL + LI+ V ++ + ++ +EL Sbjct: 4 PEESFARSAEPTLGVEWEVALVDPTTWDLVPRGAELIERVHAAAPEIHLEKEFLQNTVEL 63 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C + +A + V AA + +++ G HPF ++ V E Y + Sbjct: 64 VTGICHTVPEAVADLAHKLSHVRAAADEMGVKLWASGGHPFTDFRENPVSAKESYSEIIN 123 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y +Q ++G HVHVG D +++ L PH +A+SA SP +G DT +AS+ Sbjct: 124 RTQYWGKQMLLWGTHVHVGIRHEDRVWPIINALMTKYPHLLAISACSPAWEGLDTGYASN 183 Query: 182 RPNIFSAFPDNGPMPW-VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R ++ P G MP+ +W+++++ R + + +I+ +H+DIRP+ +GTVEVR+ Sbjct: 184 RTMLYQQLPTAG-MPYQFQSWEEWQSYMRDQAISGVINHTGSMHFDIRPASKWGTVEVRI 242 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF----NRFQACRYGLEGVI 296 D L +A L + +R E+ +L + N+++ RYG++ ++ Sbjct: 243 SDASSNLRELSAVAALTHCLV--VHYDRMIDRGEELPILQPWHVAENKWRGARYGMDALV 300 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 D R + ++ L+E++ P A ++G + + +H + G + R + G Sbjct: 301 VTSRETDERWIKDELADLVEELTPLARELGCAEELALIHEIIDDGAG-YERQRALYEETG 359 Query: 357 SLIGLVKKHCE 367 S +V+ C+ Sbjct: 360 SWQKVVEATCQ 370 >UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Corynebacterium RepID=CAAL_CORU7 Length = 394 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 98/343 (28%), Positives = 174/343 (50%), Gaps = 12/343 (3%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF SEP T+G+E E+ +++P DL + L+D + V + + +E+ T Sbjct: 2 DFPGSEP-TVGLEWEVALIDPETLDLVPRAGELLDLMDEVYPGHRVTREFMANTVEMVTT 60 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V +I A +L A + + GTHPF W QE+ D + YQ +E Sbjct: 61 VHGNIPAAVEDLREQLLQLLDCADRIGVLLFSAGTHPFTNWGDQEMSDKKSYQEIIERTQ 120 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 Y +Q ++G HVHVG S + +++ + PH +A+SA+SP +G DT +AS+R Sbjct: 121 YWGRQMIIWGIHVHVGVGSKEKVWPIINAVMTHYPHVLAMSASSPAWEGLDTGYASNRTL 180 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 ++ P G ++W ++E R + +I+ +H+D+RPS +GT+EVR D+ Sbjct: 181 LYQQLPTAGIPYQFASWDEWEEFNRDQDRSGVINHTGSMHFDVRPS-KYGTIEVRFADST 239 Query: 245 LTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKF----NRFQACRYGLEGVITD 298 + A+ I A H L+ ER + E+ L ++ N+++A RYGL+ +I Sbjct: 240 M----AIWEVAAISAYLHCLVVYFERMYDAGEELPSLQQWHVAENKWRAARYGLKALIIT 295 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 R +T++ R +E+++P A ++G + ++ + R + +G Sbjct: 296 DRETTERMVTDELRRWVEELSPLAEELGCKAELQDVLRLIETG 338 >UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=Persephonella marina EX-H1 RepID=C0QT87_PERMH Length = 362 Score = 153 bits (386), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 99/332 (29%), Positives = 162/332 (48%), Gaps = 17/332 (5%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKH-DITESMLELAT 63 DF S+PFT+GIELE+Q+V+ ++LS+ S ++ + ++ H ++ SM+E+ T Sbjct: 4 DFRSSKPFTVGIELEIQLVDRGSFELSESSEIVFSNASEGLK--KLLHPELLTSMVEIVT 61 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 VC +A K + D+ GTH F K + + +RY + LE F Sbjct: 62 PVCETPEEAVSHIKNAVKEIDLIGEDYGFRSAALGTHVFAKKETIHITAKDRYLKLLEEF 121 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L++Q ++G H+HVG + AI + +P F+A+S +SP+ G T S R Sbjct: 122 QILLKQFLIYGLHIHVGFPEKEMAIKAYNETLNNLPLFLAVSTSSPFFLGEFTGLNSFRT 181 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 IF P G + ++ FE L+ L I SIKD+ WD+R P FGTVE+RV D+ Sbjct: 182 KIFEQLPRAGIPEYFDSYSDFEKLYFTLLENGFIQSIKDIWWDVRIHPDFGTVELRVCDS 241 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDY-LLYKFNRFQACRYGLEGVITDPHTG 302 + +A L QA + F E+ + + K N++ A RY +EG Sbjct: 242 NPDMERIEFIATLFQAVCFY----SSFSSGERYFHQILKQNKWNATRYSVEG-------- 289 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 R E T+++ ++IA ++ + ++ L Sbjct: 290 -RFLYREGTVQIKKRIADIIKELKKTDILKEL 320 >UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=C1A844_GEMAT Length = 404 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 101/356 (28%), Positives = 164/356 (46%), Gaps = 6/356 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T+GIE E Q+++P DL+ L+ + ++ +VK ++ + +E+ T VC I++ Sbjct: 6 LTVGIEEEYQIIDPVTRDLTPGFDALVTSEDAQL--ADVKAELHQCQVEIGTKVCSSISE 63 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++ +V++AA H L I GTHPF W QE+ ERY L + Sbjct: 64 LRTELVKLRGLVIKAAAQHGLTIASAGTHPFSNWMNQEMTPKERYLGVKAELQDLAHRLL 123 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 +FG HVHVG + I L+ +PH + LS +SP+ G +T S R +F FP Sbjct: 124 IFGTHVHVGIEDPEFRIDCLNASRYILPHILCLSTSSPFWFGRNTGLHSYRSIVFKNFPR 183 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G ++ W + L L T I + WD+RP H+ T+E RV D + AV Sbjct: 184 TGVPRILNGWGDYADLVDTLQKTRSIPDGSKVWWDVRPHHHYPTLEFRVCDVNTRVDEAV 243 Query: 252 NMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A ++QA W L + L + N+++A R+GL G + D + P + Sbjct: 244 CIAAILQAVVAKMWKLRRDNLTFRVYASDLIEENKWRAVRWGLGGKLIDFGKKEELPASV 303 Query: 310 DTLRLLEKIAPSA-HKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 L+E ++G +E +R + G + AQ A G L +V + Sbjct: 304 LIRELVEWFLDDVLDELGTRKEVEYAYRILEEG-SSAQRQLATYARTGDLRAVVDQ 358 >UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomycetales RepID=C5BZX5_BEUC1 Length = 388 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 92/337 (27%), Positives = 166/337 (49%), Gaps = 14/337 (4%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE---VKHDITESMLEL 61 +F SE ++GIE E+ +V+ DL Q + ++DAV+ A E +K ++ + +E+ Sbjct: 8 EFAHSERSSVGIEWELALVDADSGDLRQVAQTVLDAVRPD-GAEEHPLIKQELLLNTVEV 66 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 + V R + A + + +E+ G+HPF +W +Q+V + ERY ++ Sbjct: 67 VSGVQRTVADAGRDLERAIDAIREVTDPLRVELMCAGSHPFARWTQQKVTNKERYATLID 126 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 + +Q ++G H HVG + + + PH +LSA+SP+ G DT +AS+ Sbjct: 127 RTQWWGRQMLIYGVHTHVGIEDRSKVLPIARAMLTVAPHLQSLSASSPFWGGKDTGYASN 186 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F P G + W + E + +T +ID + ++ WDIRPSP GT+EVRV Sbjct: 187 RALMFQQLPTAGLPFAFTEWAELEQYVGDMLHTGVIDDVTEIRWDIRPSPRLGTLEVRVC 246 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYL------LYKFNRFQACRYGLEGV 295 D TL + ++ A H L+ + L + N++++ RYG++ + Sbjct: 247 DGTPTLGELLALS----AFTHCLVEHFSSMLDAGEQLPAMPPWFVQENKWRSARYGMDAI 302 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIE 332 + GD R +T+ L+ + P A ++G S+ ++ Sbjct: 303 LILDADGDERLVTDSVHDWLQVLEPVAERLGCSAELD 339 >UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alphaproteobacteria RepID=CAAL_RHORT Length = 389 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 103/342 (30%), Positives = 167/342 (48%), Gaps = 15/342 (4%) Query: 8 VSEP-FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA-------GEVKHDITESML 59 + EP FT+GIE E +V+ L+ D +A+ ++ A G V + + + Sbjct: 1 MREPAFTVGIEEEYLLVDRQSRALAADPP---EALMTRLAAAFGDTNHGAVTPEFLRAQI 57 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E+ T VC + +A A+++V+ + A L THPF +W + ERY Sbjct: 58 EVGTKVCDSLAEAGEALGALRRVLAEEAKGFGLAPIAASTHPFAEWADLKHTPKERYDLL 117 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 E+ ++++ + G HVHVG D + L+ +S F+PH +AL+ +SP+ +G D+ Sbjct: 118 AEDLQAVVRRLVICGMHVHVGIEDPDLRMDLMAQVSYFLPHLLALTTSSPFWRGEDSGLK 177 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R +FSA P G S++ +++ L +I+ + WDIRPS F T+E+R Sbjct: 178 SYRIAVFSALPRTGLPDSFSSFAEYQRHVEVLVSAGLIEDSTRIWWDIRPSHRFPTLEMR 237 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVIT 297 + D L A+ +A L + L R + + Y LL NR++A RYGL+G + Sbjct: 238 IADVCTRLDDALCVAALFRCLLRMLYRLRRANQRWRHYARLLIAENRWRAQRYGLDGGLV 297 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 D G+ P + LLE IAP A G + E LH + + Sbjct: 298 DFGRGEVVPFADLIEELLELIAPDAAVFGCQA--EVLHARTI 337 >UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp. oral taxon 848 str. F0332 RepID=D0WKA5_9ACTO Length = 387 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 96/339 (28%), Positives = 158/339 (46%), Gaps = 7/339 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F SE T+G+E E+Q+V+P L ++ ++ V+ + VK ++ ++MLE + Sbjct: 5 FRDSERSTVGLEWEVQIVDPKTLKLGHNAKWILAEVRRR-GCSLVKGEMHQNMLEFVSRK 63 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + + A L A + + GGG+HPF Q V + RY+ +E Y Sbjct: 64 RVSVAECAADMEEAIDAALPYAEELGVGFSGGGSHPFAHPSDQPVSETARYRELVERTRY 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 +Q +FG HVHVG + + LS + H + +SAASPY DT +A +R + Sbjct: 124 WGRQMVIFGTHVHVGVEDRRKVAPIHNFLSAKIGHLLGISAASPYWDDVDTGYADNRAMM 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 F P G +++W E + L I ++ WD+RPSP FGT+EVR D+ Sbjct: 184 FQQLPTAGLPMHLNSWGDLERIAGDLVDVGAIREYNEIRWDVRPSPGFGTIEVRACDSAT 243 Query: 246 TLSHAVNMA----GLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 L+ +A L++ + L RP + L + N+++ RYG + + Sbjct: 244 NLAEIRAIAAFVHALVETASRELDAGRPL--LSLPFHLLETNKWRGARYGAHAELVESAD 301 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS 340 G+ PL E LL I P+A +G + + A+ + S Sbjct: 302 GECAPLAETLPDLLAWIEPAAEFLGCAEDLAAVPELIAS 340 >UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32130 Length = 382 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 103/351 (29%), Positives = 160/351 (45%), Gaps = 9/351 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F +PF+LG+E E+ +V+P + S+ +ID + G V+ ++ +EL TDV Sbjct: 15 FGEGDPFSLGVEEELFLVDPVTGEQINASTAVIDRLGP--VDGRVERELHACQVELITDV 72 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 CR +A G ++ V+ + + G GTHP + E+ D RY+R E G Sbjct: 73 CRTAGEAVGTLGGLRAAVVATG----VGLLGAGTHPAAEEGDAEITDKVRYERIRELLGD 128 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + V G HVHVG + AI +GL R +P AL A SP+ DT AS+R Sbjct: 129 AVAT-PVNGLHVHVGMPDAETAIRAFNGLRRHLPLLQALGANSPFRHSRDTGLASAREVT 187 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 +P +G + +++ F A+ L+ + W +RP P GTVE+R +DT Sbjct: 188 TRGWPRSGVPRAMRDFEDFCAMSALLARAADVPDYTWFWWKLRPHPRLGTVEIRALDTQT 247 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +L + L+ A + L F+A RYG++ + D G R Sbjct: 248 SLEDLAALVALVHCLARHASELGADPAADPPGELLDEGVFRAARYGIDAQLPDAE-GRLR 306 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 P+ ++E +AP A ++G ++ LHR V G A R A GG Sbjct: 307 PVRSLLDDVVEMVAPDARELGCEGELDGLHRLVERG-GGAGRQRSLHAIGG 356 >UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinomycetales RepID=D2AQS1_STRRD Length = 837 Score = 142 bits (359), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 99/354 (27%), Positives = 177/354 (50%), Gaps = 7/354 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P +G+E E VV+ L + +L+D ++ A H++ S++E + + Sbjct: 7 PIAVGVEEEFHVVDVDTRHLVPRAGVLLD----QLPADRFTHELQRSVVEANSRPFIRLE 62 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A+++ V+QAA L I G+ P + ++ + RY++ L ++ L ++ Sbjct: 63 DLGHDLTALRRTVIQAADGLGLGIVAAGSVPLVDLEALKISPDPRYEQMLADYQLLTREQ 122 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 + G VH + D A+ + H L+ ++P +ALS++SPY G+DT +AS RP I+ +P Sbjct: 123 LICGTQVHAEVDNRDLAVAVAHRLAPWLPPLLALSSSSPYWLGSDTGYASYRPLIWQRWP 182 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP+ + +++ + L + +I +++DIRPS H TVE+R+ D +S Sbjct: 183 TAGPVAAFESAAEYDQVVGDLVRSGVITDPGMIYFDIRPSAHVPTVELRICDACPRVSDI 242 Query: 251 VNMAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 V +AGL +A A L R + + + ++A R GLEG + DP G RP E Sbjct: 243 VLIAGLFRALVARELEAVRRGPDRSVRLEMVRAATWRAARSGLEGDLVDPVEGVPRPAAE 302 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVS-GLNEAQLMRDFVADGGSLIGLV 362 R+++ + P + G + +L +Q + G + A+ R FV GG L +V Sbjct: 303 VIGRMVDGLRPQLEESGDRELVTSLAQQALGRGSSSARQRRAFVR-GGRLADVV 355 >UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micrococcaceae RepID=CAAL_MICLC Length = 398 Score = 140 bits (353), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 106/357 (29%), Positives = 159/357 (44%), Gaps = 25/357 (7%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDA--VKNKITAGEVKHDITESM 58 M LP F S TLGIE E+ +V+ +L ++ L+ A V + +V +T + Sbjct: 1 MTLP-FADSAQSTLGIEWELALVDAVSGELRSEAPDLLRALHVAEGLADDDVNPHMTSEL 59 Query: 59 L----ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE 114 L EL T V ++ A + V AA + + GTHPF Q +E Sbjct: 60 LQNTVELVTGVHERVDAATADLGRIAARVADAAAARGISLFCQGTHPFADAIAQPSTPSE 119 Query: 115 RYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 RY R L+ Y +Q +FG HVHVG A+ +++GL VPH +ALSA+SP+ GT Sbjct: 120 RYDRMLDLTQYWGRQLLIFGVHVHVGLDDVSKAMPVVNGLVNRVPHLLALSASSPFWAGT 179 Query: 175 DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFG 234 DT + S R +F P G W+ FE + MI + + WD+R P G Sbjct: 180 DTGYQSQRTLLFQQLPTAGLPFQFQEWEDFERCVAQMEQVGMIADVTECRWDVRAVPRLG 239 Query: 235 TVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ER--------PFKHQEKDYLLYKFNR 284 TVE+R D TL + Q L ER P+ QE N+ Sbjct: 240 TVEMRACDGLATLEEIAAVTAYTQCLVDDLSASLERGETVEVLPPWHAQE--------NK 291 Query: 285 FQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 ++A RYG++ + G + PL E +E++ P A ++G + + + + G Sbjct: 292 WRAARYGMDATVIVDARGTQVPLAEHLPAEIERLTPVAERLGCEAELAGVQAMIDDG 348 >UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=CAAL1_SACEN Length = 374 Score = 137 bits (344), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 92/340 (27%), Positives = 162/340 (47%), Gaps = 4/340 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++P + + + D + + GEV ++ + +E AT VCR + + Sbjct: 4 LTLGVEEEFLLLDPG----TLEPAAAADRFRAETDRGEVHRELAPAQIESATAVCRTLEE 59 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 S +++ + A + + G P V D+ RY+R E +G +I+ Sbjct: 60 LHHDLSGLRRALAADAAEQGYRLASVGVPPIGSAGPPPVTDSPRYRRMYETYGSIIEDQG 119 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + L ++P + L+ SP+ +G DT +AS R ++S +P Sbjct: 120 VCGCHVHVGALDLETALVAGNHLRPWLPALLLLTTNSPFFRGGDTGYASWRTTLWSRWPA 179 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P +++ + + + CL + + L+W RPS T+EVRV D T+ AV Sbjct: 180 AGPPPVLTSARHYHYVVDCLLASGAVLDSGMLYWYARPSHRVPTLEVRVADAAATVDEAV 239 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 +AGL++ L++RP + D + + + + +GLEG D TG P Sbjct: 240 LLAGLVRGLVGVALSDRPGPVRPVDDAVLRAACWCSAHHGLEGFSLDVGTGRLVPSWHLV 299 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDF 351 L+E + P + G A+ AL ++ + A+ R+ Sbjct: 300 DDLVEHVRPVLERYGDLDAVRALLAKLRENGSAARRQREV 339 >UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobacteriaceae RepID=C7NRF5_HALUD Length = 365 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 85/291 (29%), Positives = 144/291 (49%), Gaps = 16/291 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 TLGIE E VV+ G +S +++ ++ I + H++ + ++E T V D A Sbjct: 14 TLGIEEEFFVVDEYGRPVSGTDTLVYNSEPPAILENRLDHELFKFVIESQTPVIEDPGDA 73 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 A SA++ +++ A DH EI G HP +W+ E + RY+ L+ Y + T Sbjct: 74 AATLSAVRGALVEHARDHGFEIAAAGLHPGARWRELEHAEKPRYRSQLDRIQYPQHRNTT 133 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + A+++ + + +P +AL+A SPY G DT +S+R +F P+ Sbjct: 134 AGLHVHVGVDDAEKAVWIANKIRWHLPIVLALAANSPYWNGFDTGLSSARAKLFEGLPNT 193 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKD---LHWDIRPSPHFGTVEVRVMDTPLTLSH 249 G MP + + FE+ R DSI D L +D+RP +GTVEVR D + Sbjct: 194 G-MP--TTFDSFESFHRFEQRMIETDSISDRGELWFDVRPHTEYGTVEVRTADAQADIDR 250 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYL------LYKFNRFQACRYGLEG 294 + + + H L+ + ++++ + + L N+++A R+G E Sbjct: 251 VLALVEYV----HELVLDLAARYEDGETITAVRRELLDENKWRAIRHGREA 297 >UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2AQR8_STRRD Length = 370 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 93/327 (28%), Positives = 152/327 (46%), Gaps = 5/327 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T+G+E E + + + +++ G V+ ++ + +E + VCRDI Sbjct: 6 LTVGVEEEFFLADVATRHAVLRAETVLEGTAPVPGGGRVEPELARAQVESVSAVCRDIGS 65 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + +++ V AA + + G P V D RY R E FG L+ Q + Sbjct: 66 LREELLRLRRSVAAAAESNGCRLVASGVVPLGDPGPPPVSDRPRYHRIAERFGPLLDQQS 125 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 HVHVG ++A+ +++ L ++P + LS+ SP+ +G DT +AS R +F+ +P Sbjct: 126 ACACHVHVGVPDPEEAVQVVNHLRMWLPVLLVLSSNSPFWRGRDTGYASWRTPLFARWPT 185 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P++S ++E + CL T I L W RPS H TVEVR+ D T+ V Sbjct: 186 AGPPPYLSGRAEYEEIVECLRETGAILDGGMLFWYARPSRHVPTVEVRIADVMPTVDDTV 245 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITD-PHTGDRR--P 306 A L++A +LT+ R L + ++A RYGL G D D R P Sbjct: 246 LFAALVRALVATVLTDLRRGRAAPAAGDHLLRAACWRAARYGLRGDGVDVSGRVDERLIP 305 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEA 333 + +L+E ++P+ G A+ A Sbjct: 306 ASGQIKQLMEYVSPALEASGEDGAVRA 332 >UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopirellula baltica RepID=CAAL_RHOBA Length = 372 Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 90/361 (24%), Positives = 167/361 (46%), Gaps = 20/361 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVK----NKITAGEVKHDITESMLELATDVCRD 68 T+G+E E Q+V+P L + ++ ++ ++ E++H++ + +E+A+DVC Sbjct: 7 TVGVEEEYQLVDPRSGALIPNCKEVMRTIRRNGGSEEAHSEIQHELHLNQIEMASDVCSS 66 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 + + + +++++ AA + E+ GT+P + +RYQ + + + + Sbjct: 67 LEEVRDALTQTRRMLIDAARSNETELASAGTNPLPIPTDDALTPKDRYQAMTDRYQQIAR 126 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 +FG HVHV + I +++ R++P A++A SPY G DT +AS R +++ Sbjct: 127 DLFIFGCHVHVAMEDRELGIQVMNRCRRWLPILQAITANSPYWDGVDTGYASYRRELWAQ 186 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKD---LHWDIRPSPHFGTVEVRVMDTPL 245 +P GP + +++ C+ +IKD L+WDIR T+E R D Sbjct: 187 WPMAGPPAHFDSLADYQS---CVDDLVACGAIKDESFLYWDIRLPTRVPTIEFRAADVMT 243 Query: 246 TLSHAVNMAGLIQATAHWLLTE----RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 + V G+I+A ++E +P L Y + A RYG+ + DP + Sbjct: 244 RVEETVGYVGMIRAIVMLAISEEEQGKPIVPIRPSVLSYAI--WHAARYGMNEQLVDPES 301 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 + P +E RL+ I P+ G + +EA Q++ A R GG L + Sbjct: 302 REMIPASELLNRLMTAIDPALKATGEARPVEAFANQLIKSGTGADRQR----RGGELSSV 357 Query: 362 V 362 V Sbjct: 358 V 358 >UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6W8C0_ACTMD Length = 373 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 98/350 (28%), Positives = 168/350 (48%), Gaps = 13/350 (3%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 +P+P T+G+E E +V+ +L ++ ++ +++ ++T+ +E Sbjct: 9 LPIPRSGSGTALTIGVEEEFLLVDEVTGELVPLGPQVLSGPPDR--GLDLQPEMTQYQVE 66 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 AT VCR ++ Q A + + + A H + G + D+ RY+R + Sbjct: 67 SATAVCRTASEVREQLLAARAALARRAAAHGARLVASGAPVLGGEHPPPLTDHPRYRRIM 126 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +G L+ T+ G HVHVG S + + + + L R++P +ALSA SP+ +G DT +AS Sbjct: 127 ERYGALVDGLTICGCHVHVGIPSPSEGLVISNHLRRWLPVLLALSANSPFHEGRDTGYAS 186 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R +++ +P GP PW + + + L + ++WD+R S + TVE+RV Sbjct: 187 WRHVVWNPWPSAGPPPWFDSVEDYRLATHLLRTSGAALDDGMVYWDVRLSANHPTVELRV 246 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D T+ AV +A L++A A L+ + D LL + +QA R+G EG DP Sbjct: 247 CDVAATVEEAVVLAALVRAIAATALSGE-AAPRVSDRLL-RVALWQAARHGPEGAAVDPL 304 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRD 350 +G P E+ LL + G + VV G+ A+L+RD Sbjct: 305 SGVPVPFAEEVGGLLRWCGAALDAAGDTE-------LVVEGV--ARLLRD 345 >UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Halobacteriaceae RepID=CAAL_HALWD Length = 363 Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 144/307 (46%), Gaps = 16/307 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVK--NKITAGEVKHDITESMLELATDVCRDIN 70 TLG+E E VV+ G + ++ D + A + H++ + ++E T + D++ Sbjct: 14 TLGVEEEFFVVDDSGQPTAGIQELIYDYNHPPAGVLADRLDHELFQFVIETQTPLLEDVS 73 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + A++ ++ A DH I G HP KW+ + + RYQ L+ Y + Sbjct: 74 AVSESVQAVRDALVTHAADHGYRIAAAGLHPTAKWRERNHVEKPRYQSQLDRIQYPQHRN 133 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 T G HVHVG D A ++ + L ++P +ALSA SPY G DT AS+R IF A P Sbjct: 134 TTAGLHVHVGVDDPDAATWIANELRWYLPPLLALSANSPYWNGFDTGLASARAKIFEALP 193 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKD---LHWDIRPSPHFGTVEVRVMDTPLTL 247 + G MP + ++ FEA ++ SIKD L +D+RP GTVEVR D Sbjct: 194 NTG-MP--TRFEDFEAYYQLEKRMVETGSIKDRGELWYDVRPHTGHGTVEVRTPDAQADP 250 Query: 248 SHAVNMAGLIQA-----TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 S V + I A A + E K + + + N++ A RYG + P + Sbjct: 251 SVTVAIVEYIHALVMDFAARYADGESGTKVRRE---ILDANKWHAMRYGRDAEFIIPGSM 307 Query: 303 DRRPLTE 309 + L+E Sbjct: 308 ETVTLSE 314 >UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL3_RUBXD Length = 384 Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 94/332 (28%), Positives = 146/332 (43%), Gaps = 26/332 (7%) Query: 1 MPLPDFHVSEP-FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESML 59 +P F P TLG E E+ + +P L+ + ++ A + +GE + + + Sbjct: 15 LPEEAFETGAPEGTLGAEEELWLADPETLKLAGGAQKILAAEPAEHFSGE----LIDCEV 70 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E T V R+ A A ++ +L+ A + GTHP W+ QE+ D YQ Sbjct: 71 EANTGVHREAAGVARDLLARRRTLLEHAGRLGRVLGTSGTHPLGDWREQEIIDKPHYQYL 130 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQG--TDTR 177 G+LI++ F HVH + IYL + +VPHF+A+S SP+ QG TDTR Sbjct: 131 KRKLGWLIRRNNTFSLHVHYAVQGKEKVIYLFDRIREYVPHFLAVSVNSPFWQGEFTDTR 190 Query: 178 FASSRPNIFS-AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTV 236 S+R +FS + P G +W + + +I + ++ WDIRP P T+ Sbjct: 191 --SARALVFSRSLPHAGMPEAFGSWSAYAGYLDFVGRPGVIRRLGEIWWDIRPHPRLSTL 248 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHWLLTE---------RPFKHQEKDYLLYKFNRFQA 287 E+R D + + + L AT L E RP + E N++ A Sbjct: 249 EIRAFDAQTDPARSEALISLAAATCDMLCAEYESGELRPARPVREIED-------NKWSA 301 Query: 288 CRYGLEGVITDPHTGDRRPLTEDTLRLLEKIA 319 R+GL+G+ D T + P RL E A Sbjct: 302 QRHGLDGLFVDHETHEPVPARWAVERLAELAA 333 >UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WA32_ACTMD Length = 363 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/309 (29%), Positives = 152/309 (49%), Gaps = 7/309 (2%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG-EVKHDITESMLELATDVC 66 +++P+T+G+E E +V+P ++ L +AV ++ A +V+ ++T +E+AT VC Sbjct: 1 MTQPWTVGVEQEFLLVDP----QTRRPVPLAEAVADRAGASFDVQRELTPFQIEVATPVC 56 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 + A Q A ++ + +AA + P + ++ RY R + Sbjct: 57 HSSAELAEQVLAGRRHLAKAARAAGGALMASAVPPLGMTGPPSITEDARYLRMQYTHRKM 116 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + V G HVHVG + AI + L ++P +ALSA SP +G DT ++S R ++ Sbjct: 117 LAGQGVCGMHVHVGVPDRETAIRASNALRPWLPSLLALSANSPVEEGQDTGYSSWRSIVW 176 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P + ++AL L T ++ ++WD+RPS H TVE+RV D PLT Sbjct: 177 SRWPVGGPPPQFTGAGHYDALVSALVGTEVVLDPAMVYWDVRPSTHVPTVEIRVADIPLT 236 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 AV +A L++A P + + +L + ++A R G +G DP TG P Sbjct: 237 AKDAVVIAELVRAFVRTAADSAPT--EPVNDVLLRAAYWRAARDGADGQGIDPRTGSLVP 294 Query: 307 LTEDTLRLL 315 + LL Sbjct: 295 ARDLLAELL 303 >UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32412 Length = 381 Score = 127 bits (318), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 101/359 (28%), Positives = 158/359 (44%), Gaps = 16/359 (4%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVK-NKITAGEVKHDITESMLELATD 64 F S FT+G+E E V++P L+ L DA + + + A + ++ S +E+ + Sbjct: 12 FEDSTDFTVGLEEEFAVLDPGTRALTPRFEELRDAAQADPVLAESIAGELISSEIEIRSG 71 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 D+ AA + ++ + A + + + GTHPF ++ Q + D E Y R + Sbjct: 72 KGVDVADAAIRQRDHRRRLFALAQERGIALGATGTHPFSDYREQRIIDTEHYHRVEDGLK 131 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 Y+ + F HVHVG D A+ + L +P +A+SA SPY+ G D+ + R Sbjct: 132 YVAWRNNTFSLHVHVGVQGADRAVQVCDRLRPVLPLLLAISANSPYVDGRDSGLHTVRTQ 191 Query: 185 IFS-AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 F+ +FP G +WQ F + L T I + W +RP FGTVEVR+ D Sbjct: 192 TFTKSFPRCGVPDAFGSWQAFRSYLEFLVATNSIVEYTQVWWSVRPHLSFGTVEVRICDA 251 Query: 244 PLTLSHAVNMAGLIQA----TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 T + +A LI A A + PF + L + N ++A R GL+G + D Sbjct: 252 QSTAGESDGLAALIVACVAQAARDVEDGVPFA--DPPARLIEENMWRAIRRGLDGPLIDL 309 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 P RLL AP ++G A+ LN AQ R + G + Sbjct: 310 ERAVEFPGQAALERLLAWTAPVRAELGIDVALPE--------LNGAQRQRRMIDAGAGI 360 >UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Streptomyces RepID=CAAL2_STRAW Length = 366 Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 92/351 (26%), Positives = 166/351 (47%), Gaps = 9/351 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESMLELATDVCRDI 69 +T+G+E E +++P + + A + AGE ++ +++E+ +E+AT VC + Sbjct: 4 YTVGVEEEYLLLDPATRLPMPAAEQVRAAAGLEPIAGEDEIQPELSEAQVEVATPVCTSL 63 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 ++ G ++ V+ +AA + + GT P ++ + +N RY+ L+ + Sbjct: 64 DEIGGHLVRLRHVLGRAAESNGCRLAACGTPPIKEESPPPLTNNPRYRAMRAQAPQLVAE 123 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG + + +L+ + ++P +A+SA SP+ G DT FAS R IF + Sbjct: 124 QLVCGTHVHVGVPDPEIGVAVLNRIRLWLPVLVAMSANSPFWAGHDTGFASWRTVIFGRW 183 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P +GP P ++ E + L +I L+W R S + TVEVR +D L Sbjct: 184 PVSGPPPHFADLADHEKRVQQLLTCGVIFDPGQLYWQARLSSRYPTVEVRCLDVQLRADD 243 Query: 250 AVNMAGLIQATAHWLLTER----PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 AV AG+++A + + P + L + + A R+GL G + D + G RR Sbjct: 244 AVMFAGIVRALVATAINDAKAGVPVPSCPPE--LLQGANWHAARHGLSGSLID-YEGRRR 300 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 + +L++ I P+ S + +L +++ A R + GG Sbjct: 301 SAGDVLSQLMDHIGPALDAADDSREVASLVHRLLREGTPADRQRRALLRGG 351 >UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JVV2_RHOER Length = 392 Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 99/340 (29%), Positives = 166/340 (48%), Gaps = 10/340 (2%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG-EVKHDITESMLELATDV 65 H S T+G+E E +V+P + S D++ + + T G +++ +++ +E + V Sbjct: 14 HESTTPTVGVEEEFILVDPTSWLPSTDNAAVAETAS---TLGLDLQLELSRCQVETNSPV 70 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C I++ + M+++ +AA + + G P R E+ D+ RY+R E FG Sbjct: 71 CHGIDELRTHLTDMRRLAAKAAELNGCRLLAVGA-PLSGPSRFEISDSPRYRRMGERFGA 129 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L + ++ G H+HVG A A+ + + + ++P +ALSA S QG DT FAS R Sbjct: 130 LAAEQSICGCHIHVGVADQVQAVQVCNHVRIWLPALLALSANSRVHQGVDTDFASWRAIQ 189 Query: 186 FSAFPDNGPMPWVSNWQQFE-ALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +S +P GP P+ F+ A+ + + M+D + +WDIRPS H TVE+RV D Sbjct: 190 WSRWPVAGPPPYFETTGDFDTAVAKMVDCGVMLDK-RMAYWDIRPSCHLPTVEIRVCDVQ 248 Query: 245 LTLSHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 T A +A L +A L +R + + + + + G+ G DP T Sbjct: 249 PTAEDAALLATLGRALVATALRAIDRGIEAPNISLESLRLATWVSAKEGVLGASIDPITS 308 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIE-ALHRQVVSG 341 R TE RLL + S + G +++E AL + V+G Sbjct: 309 QRISATELLHRLLIHVRDSLDEGGEYASVESALQHKSVTG 348 >UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31B6A Length = 378 Score = 124 bits (310), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 92/358 (25%), Positives = 164/358 (45%), Gaps = 17/358 (4%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F + T+G+E E+ +++P L+ + L+ + K ++ + +E++T Sbjct: 19 FDATGGLTVGVEEELMLLDPATLALAPMAGELLQRLGGDT---RFKPELPAAQVEISTAA 75 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + A Q +A ++ + AA L G HPF + + RY +G Sbjct: 76 AASVADAVAQLAAARRDLAAAAGGLVLP-AAAGVHPFSGAE-GALNRGGRYDVLQAEYGP 133 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++ V G VHV D + + + L ++P AL+A +P+ G D+ AS RP I Sbjct: 134 IARRQLVAGLQVHVAVGGADRTLAVYNALRAYLPELAALAANAPFHCGRDSGLASVRPTI 193 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 P G P + +W QF A R + + + W++RP FGT+E+RV D Sbjct: 194 SEQLPRQGVPPRLESWDQFAAELRWGALAGSVPEPRMWWWELRPHATFGTIELRVPDAQT 253 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLL------YKFNRFQACRYGLEGVITDP 299 ++ A + QA L+ +H ++ LL + NR+ A R+GL+G + D Sbjct: 254 SVGEAAGVIAFAQA----LVATLAERHDAREALLDAPTWRIEENRWSALRHGLDGTLADL 309 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS--GLNEAQLMRDFVADG 355 TG+R P + L+ +AP A ++G + A+ A +V+ + + ++ RD DG Sbjct: 310 VTGERVPTRDRLGELVAAVAPEAERLGCADALTATRAAIVANGAVRQREVARDRGVDG 367 >UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales RepID=D2BAT9_STRRD Length = 386 Score = 119 bits (297), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 99/347 (28%), Positives = 161/347 (46%), Gaps = 7/347 (2%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F P +G+E E VV+P ++ +++ +++ ++ +V +IT +E T Sbjct: 11 PTFDALCPL-VGVEEEYLVVDPSTRAVAPEAAGVVERAAAEL-GEQVSTEITRFQVEAKT 68 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 C DI++ G+ M+ + AA L + GT + + D+ RY ++ + Sbjct: 69 PPCADISELEGRLRRMRSAMAAAARAGGLAVVASGTPVLGEVVPPPITDHPRYDVGIDTY 128 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L + ++ HVHV + A+ + + L ++P IAL A SP+ G DT +AS R Sbjct: 129 RALHDEQSICAGHVHVHLPDRERAVLVSNHLRPWLPVLIALMANSPFWAGRDTGYASWRT 188 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 + +P GP P+ ++ +FE L L+ ++ + WDIRPS T+EVRV D Sbjct: 189 LSWGKWPVAGPPPYFASLAEFEELIGTLTGAGVLVDPGTIFWDIRPSARLPTLEVRVTDV 248 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYL---LYKFNRFQACRYGLEGVITDPH 300 P T + +A +++A + ER L L + +QA R GLEG DP Sbjct: 249 PATAEESALLAAVVRALVV-VSLERVDSGDPGPRLSAELLRAAYWQAARDGLEGQGIDPL 307 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEA-LHRQVVSGLNEAQ 346 TG P E LL I PS + G + A L R +G A+ Sbjct: 308 TGRLAPAAELCEALLRHIGPSLERTGDLETVTARLKRLRAAGSGAAR 354 >UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6WDG9_KINRD Length = 850 Score = 117 bits (294), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 93/361 (25%), Positives = 165/361 (45%), Gaps = 11/361 (3%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG E E+ +++ LS + ++ +++ ++ + +E TDV + + Sbjct: 1 MTLGAEEELHLIDLGSGQLSARAPQVL----SRLDPASYSAELQRTTVETNTDVVTSLTE 56 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++K +++AA L + GT P + E+ RY R E + L+ + Sbjct: 57 LREELLRLRKGLVEAAARDGLGVAAVGTAPRSTFTDFELTATGRYGRMQEQYRLLVDEQL 116 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G VHVG + D A+ ++ ++ +P +ALSA+SP+ G DT +AS R ++ +P Sbjct: 117 ICGTQVHVGVSDRDLAVEIMQRVAPSLPVLLALSASSPFWNGQDTGYASIRTTVWQRWPT 176 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G + + Q++ L L + +I K ++D+RPS H T+E+RV D + AV Sbjct: 177 AGSTGPLESAAQYDELLADLIASGVIGDEKMAYFDVRPSSHAPTLELRVADACPLVDDAV 236 Query: 252 NMAGLIQATAHW----LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR-P 306 +AGL +A +L RP L++ +QA R GL G + D R P Sbjct: 237 LIAGLFRAGVRAAELDVLAGRPRPQVPSP--LHRAGIWQAARGGLSGNLLDGTEHPRPVP 294 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHC 366 E LL ++ P ++G + L ++ N A R + G L +V+ Sbjct: 295 APEAVRALLTRLRPQLEELGDWEEVAELTEATLARGNSADRQRAAFVERGELDDVVRLVV 354 Query: 367 E 367 E Sbjct: 355 E 355 >UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=Streptomyces sp. AA4 RepID=UPI0001B55095 Length = 364 Score = 117 bits (293), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 143/311 (45%), Gaps = 4/311 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 + T GIE E VV+ G L+Q ++ A + GE++H++ +S E+ATDVC Sbjct: 4 QTGDELTFGIEEEFFVVDRDGR-LAQADDVVDRAAETGGENGELQHELIQSQAEIATDVC 62 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 R ++A + +++ + AA + + P EV +N RY+R E+FG Sbjct: 63 RTRDEALRRLRELREDLASAARKRGRRLLPAASPPVSAEDLPEVTENPRYERIGEHFGAT 122 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + + G HVHV + I +L + ++P + ++A S G DT + S R + Sbjct: 123 ARTSLTCGCHVHVAIPDKETGIQVLGRIRPWLPVLLTVTANSAIADGYDTGYRSWRYQQW 182 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P ++ ++E++ + I ++WD+R S T+E R+ D T Sbjct: 183 SRWPSAGPPPRFASLDEYESIVDAWLRSGAILDRGMVYWDVRLSEKQPTIEFRIADVAAT 242 Query: 247 LSHAVNMAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 AV + L + A L + P + L + ++A R G+ G P +GD Sbjct: 243 PEEAVLLGVLARGLVATALADDGPPPDLPNEVLRAQL--WRASRDGVSGCCPHPRSGDLA 300 Query: 306 PLTEDTLRLLE 316 P E L+E Sbjct: 301 PTKEVLADLIE 311 >UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JMG1_RHOER Length = 382 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 96/353 (27%), Positives = 162/353 (45%), Gaps = 12/353 (3%) Query: 2 PLPD-FHVSEPFTLGIELEMQVVNP-PGYDLSQDSSMLIDAVKNKITAGEVKHDITESML 59 P PD F V P TLG+E E + +P G +++ + A + ++ ++T + Sbjct: 5 PTPDIFSVGTP-TLGVEEEFLLCDPQTGRPTLRNAEV---AAAGRELGISLQLELTRCQV 60 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E +T + I Q + V AA ++ GT PF E+ RYQR Sbjct: 61 ETSTSIGSHIRDLRDQLCESRAVTADAAARVGCQLIAVGT-PFYDPPVDEITQTSRYQRM 119 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 FG I + + G H+HVG + ++ +++ L ++P +AL+A SP G DT +A Sbjct: 120 AGQFGA-ITEGVMCGCHIHVGVEDRERSVQIINHLRPWLPTLLALTANSPISAGRDTGYA 178 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R +F +P +GP P + +E + T +I ++WD+R S H TVE+R Sbjct: 179 SWRYVLFGRWPSSGPPPCFESVAHYEDAVAAMLETGVILDPHMVYWDVRMSDHLPTVEIR 238 Query: 240 VMDTPLTLSHAVNMAGLIQA---TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 + D P T+ + +A L+QA TA +T + D+ L + ++A R GL+G Sbjct: 239 ISDVPATVEETMTLATLVQALVGTASAAIT-KGEAAPAVDHELLRAACWRAARDGLDGRS 297 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMR 349 D + + +L++ + P+ G + A +V S N A + R Sbjct: 298 LDVESVRLLTAHQAVRQLVDHVEPALTAFGEFEQVTASLDKVFSNGNGAIVQR 350 >UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B5549F Length = 381 Score = 113 bits (282), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 93/343 (27%), Positives = 150/343 (43%), Gaps = 8/343 (2%) Query: 3 LPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV---KHDITESML 59 LP H S P TLG E E +V+ + ++D G V + ++ SM+ Sbjct: 13 LPAAH-SAPPTLGAEEEFLLVDAETLVPVDAAERVLDVHHRLHPKGAVTVPQRELLSSMI 71 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E + VC + + + SA ++ +++AA + GT Q R + Y+ Sbjct: 72 ETTSPVCAGLPELRAEVSAARERLVEAAAKAGCRVLAHGTAARQAPPRTPT-EAPHYRDV 130 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 + L Q G H+HVG + A++ L + ++P +ALSA SPY G DT FA Sbjct: 131 AGLYRLLAQGTETCGCHIHVGVPDREAAVHALDHVRPWLPVLLALSANSPYEHGVDTGFA 190 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMI-DSIKDLHWDIRPSPHFGTVEV 238 S R + S +P P+ ++ ++A R L T ++ + ++ +W RPS H T+EV Sbjct: 191 SWRTMVLSRWPTTQIPPYFTDAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEV 250 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR--FQACRYGLEGVI 296 RV D T+ AGL +A L ER + + A RYGL G + Sbjct: 251 RVADVMPTVREVAAQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSL 310 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 P +G P E LL + + +G + A+ R ++ Sbjct: 311 VHPGSGTAVPAGEAVAALLAHVGEALADLGDEEEVTAVVRDLL 353 >UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseudomonas mendocina ymp RepID=CAAL_PSEMY Length = 378 Score = 112 bits (279), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 82/316 (25%), Positives = 146/316 (46%), Gaps = 16/316 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T GIE E + + +++ + V ++ + E+ T V + A Sbjct: 5 TFGIEEEYFLTDLTSRQVARRNVEAFATACQYELGERVTREMFAAQFEVVTPVLHSLTDA 64 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 ++ + + A + + GTHP +W+R D RY+ +++ + ++ + Sbjct: 65 RQCLEGARRALARLAREFDCGVLAAGTHPLGQWRRVRATDMPRYRAIFDDYRMVASRSVL 124 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG A G D I L++ L+ ++P + LSA+SP+ G + S R + +P Sbjct: 125 AGLHVHVGVAEGVDRIRLMNRLTPWLPLLLGLSASSPFWNGRPSGLMSYRQAVCDEWPRM 184 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G ++ +++ + ++ T I S +L W+IRPS + T+E+R+ D L A+ Sbjct: 185 GIPDHFADEAEYQRYVQVMTDTGCIRSAANLWWNIRPSLRYPTLELRIADACPRLDDALC 244 Query: 253 MAGL-------IQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +AGL +Q T H + P +L NR++A R GL G+ +P +R Sbjct: 245 LAGLFRAMVEHVQLTPHHAWCDDPLTR-----VLTLENRWRAKRQGLRGLFIEP--ASQR 297 Query: 306 PLTEDTL--RLLEKIA 319 LT T +LE+IA Sbjct: 298 LLTFATWLEEVLERIA 313 >UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia sp. EuI1c RepID=D1VQ82_9ACTO Length = 901 Score = 111 bits (278), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 90/337 (26%), Positives = 151/337 (44%), Gaps = 20/337 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G+E E +++ L + +++A + AG ++ +S++E + RD+ Sbjct: 11 AVGVEEEFHILDLVTRALVPRAGEILEA----LPAGRFTSELLKSVVETNSAPTRDLAAL 66 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 ++ + AA L GT P R EV + RY + E + L ++ + Sbjct: 67 RADLVDLRHELAAAAEPLGLGPVAAGTVPIVDPDRLEVSRDPRYLQMTEEYQILAREQVI 126 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHV D A+ ++ + ++P F+ALSA+SP+ G D+ +AS R ++ +P Sbjct: 127 CGAHVHVDVGDRDTAMAVIARVGPWLPLFLALSASSPFWLGADSGYASMRTMVWQRWPTA 186 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G +++ L L + +I +++DIRPS H TVE+RV D + V Sbjct: 187 GVTGRFQTAAEYDQLVADLVKSGVISDPGMVYFDIRPSAHLPTVELRVCDACPDVDTVVL 246 Query: 253 MAGL--------IQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 +AGL + A L E P L + ++A R GLEG + +P G Sbjct: 247 IAGLFRGLVSHSVAAIEAGLPVELPRAE------LLRAATWRAARSGLEGDLVEPSGGGA 300 Query: 305 RPL-TEDTL-RLLEKIAPSAHKIGASSAIEALHRQVV 339 P+ ED L RLL +I P G + L Q + Sbjct: 301 GPVPAEDLLGRLLAEIRPQLETAGDWELLTELAEQAI 337 >UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1A6U3_THECD Length = 372 Score = 110 bits (276), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 100/356 (28%), Positives = 155/356 (43%), Gaps = 4/356 (1%) Query: 9 SEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD 68 E G+E E V++ + +I+ ++ V +IT +E T C Sbjct: 5 GEALRFGVEEEFLVIDRRTRATVAGAPAVIERAAARL-GDRVCGEITLVQVESRTRPCTT 63 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 + AGQ +A + + AA L + GT + + R R F L Sbjct: 64 AAELAGQIAANRAHLAAAADGGGLGVIASGTPVLGGAVPSPITEGPRQNRGNATFRGLHH 123 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 +A HVHV A + A+ + + L +P IAL A SPY DT +AS R ++S Sbjct: 124 EAAFCALHVHVEMADRERAVRMSNHLRPHLPVLIALGANSPYWCERDTGYASWRTLLWSR 183 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLS 248 +P GP P++ + + ++ L + + + ++ WDIRPS H T+EVRV D P+T Sbjct: 184 WPVAGPPPYLESAEHYDTLVATMQEAGALVDVGNVFWDIRPSAHLPTLEVRVSDVPITAE 243 Query: 249 HAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + +A L++A LL +R L + ++A R GL G D HTG P Sbjct: 244 ESAALAALVRALITSLLPAVDRGEDGPHLRPELLRLAYWRAARDGLSGSGVDVHTGKLLP 303 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 E RLLE P + G + R+++ + A R A GG L G+V Sbjct: 304 AVELAERLLETARPGLERHGDLGRVTGWLRRLIEHGDGASRQRR-AARGGGLTGVV 358 >UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environmental samples RepID=C0INB1_9BACT Length = 384 Score = 110 bits (276), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 134/311 (43%), Gaps = 4/311 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P+ +GIE E V + ++ + S K V ++ +S +E+ T C + Sbjct: 12 PYRIGIEEEYFVSDLRTGNVRRIMSKAFYNACEKELGEAVTPELLQSQIEVRTPPCGTMQ 71 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A S ++V+ + A H L I GTHP W Q+ + ERY E+ L + Sbjct: 72 EARDHLSHYRRVLAREAVRHSLAIVASGTHPLAIWHEQQQTEKERYGEVREDLQMLAMRN 131 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV + + +++ L F+P +ALS +SP+ QG T R + P Sbjct: 132 MVCGMHVHVEVPDPESRVGIMYRLMPFLPPLLALSTSSPFWQGYRTGLLGYRLTAYDELP 191 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G N +++ L+ +I L W +RPS T+E+RV D + Sbjct: 192 RTGLPELFRNAEEYRRYVDTLTEAGVIKDASFLWWAVRPSLAHPTLELRVADCCTHVEDT 251 Query: 251 VNMAGLIQATAHWLLTERPFKHQEKDYL---LYKFNRFQACRYGLEGVITDPHTGDRRPL 307 + +A + + L+ E + + D + + N+++A RYG D RP+ Sbjct: 252 LAIAAIYRGLMRHLV-EHAELNADLDVVGRAVAMENKWRAQRYGTAATFIDARARTARPI 310 Query: 308 TEDTLRLLEKI 318 + +LE I Sbjct: 311 ADVLRYILELI 321 >UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GGR3_9ACTO Length = 377 Score = 110 bits (276), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 89/317 (28%), Positives = 141/317 (44%), Gaps = 7/317 (2%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV---KHDITESMLELATDVCR 67 P TLG+E E +V+ + ++D G V + ++ SM+E + VC Sbjct: 47 PPTLGVEEEFLLVDAETLLPVDAAERVLDVHHRLHPQGAVTAPQRELLSSMIETTSPVCA 106 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D+ + SA ++ +++AA + GT Q R + Y+ + L Sbjct: 107 DLPGLRAEVSAARERLVEAAGKAGCRVLAHGTAGRQAPPRTPT-EAPHYRDVAGLYQLLA 165 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + G HVHVG + A++ L L ++P +ALSA SPY G DT FAS R + S Sbjct: 166 RGTETCGCHVHVGVPDREAAVHALDHLRPWLPVLLALSANSPYEHGADTGFASWRTMVLS 225 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMI-DSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P P+ ++ ++A R L T ++ + ++ +W RPS H T+EVRV D T Sbjct: 226 RWPTTQIPPFFADAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEVRVADVMPT 285 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR--FQACRYGLEGVITDPHTGDR 304 + + AGL +A L ER + + A RYGL G + P +G Sbjct: 286 VREVASQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSLVHPLSGVA 345 Query: 305 RPLTEDTLRLLEKIAPS 321 P E LL + P+ Sbjct: 346 VPAREAPAALLVDLGPA 362 >UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actinomycetales RepID=CAAL2_SACEN Length = 391 Score = 108 bits (270), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 93/330 (28%), Positives = 150/330 (45%), Gaps = 9/330 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDS-SMLIDAVKNKITAGE-VKH-DITESMLELATDVCRD 68 T+G+E E +V+ L+ + ++L +A + A + V H ++ S +E AT CR Sbjct: 21 VTIGVEEEFLLVDAASGQLAPHAEAVLAEAANGPLGAPDAVLHAEMLNSQVEAATGCCRT 80 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 + + Q A + + +AA+ I GT P + + +R+ E + + Sbjct: 81 LEELRSQLVAARTSLDRAASVAGARIVSSGT-PVLAVEGTGTSNGQRFADIAERYRAVAS 139 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 V G HVHVG D A+ +++ L ++P +A+SA SP+ G DT AS R Sbjct: 140 DYHVCGCHVHVGVPDRDTAVAVVNHLRPWLPTLLAISANSPFHLGHDTGHASWRGVQQRL 199 Query: 189 FPDNGPMPWVSNWQQFE-ALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P +G P + ++ + R + ++D W RPSPH TVE+RV D +T Sbjct: 200 YPGSGVPPHFPSRDAYDREVARLVDCGALVDDRMSF-WMARPSPHLPTVELRVADALITA 258 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQ--EKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 V A L +A L + + E + + A RYGL G DP R Sbjct: 259 EETVLQAALSRALVRAALDDLAAGREGDEVSDQVAAAAVWNASRYGLRGPAVDPVPARRV 318 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAI-EAL 334 P E RLL ++ P+ + G S+ + EAL Sbjct: 319 PALEMVERLLRRVGPALEQTGDSALVREAL 348 >UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinomycetales RepID=B8HF13_ARTCA Length = 409 Score = 108 bits (269), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 148/337 (43%), Gaps = 13/337 (3%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKI--TAGEV-KHDITESMLELATDVCR 67 P T G+E E+ +V+P D + L+D + +AG V + + M+E+ T Sbjct: 33 PRTFGVEEELLLVDPGRGDAVPMAGALLDLYVRPLESSAGPVLTAEFQQEMIEVVTPPHS 92 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A + + QAA D + + GT P R+ +E +G Sbjct: 93 TLAGLQADIVAGRDIARQAAEDVGVRVAALGTSPLPS--DPHPVRLRRFAAMVEEYGLTA 150 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ G HVHV S ++A+ +L + ++P +ALSA SP+ G DT +AS R ++S Sbjct: 151 REQLTCGTHVHVSVESDEEAVGVLDRIRNWLPVLVALSANSPFWHGEDTGYASYRSQVWS 210 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP+ + + L + T + +++D R S H+ TVEVR+ D + Sbjct: 211 RWPSAGPLDILGTPDAYHQLVHDMVSTGVAMDEGMIYFDARLSRHYPTVEVRIADACMMP 270 Query: 248 SHAVNMAGLIQ-----ATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 + V +AG+++ A W P L + ++A R+GL G + DP T Sbjct: 271 ENTVLLAGIVRGLVETAAREWKAGTGPAPVPTA---LLRLAGWKASRWGLRGELLDPVTS 327 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 P LL I + +G +E L Q++ Sbjct: 328 RPGPALGVVNSLLHHIHGALEDMGDLERVEELTDQLL 364 >UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=Bacteria RepID=CAAL4_RHOSR Length = 793 Score = 107 bits (268), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 87/362 (24%), Positives = 164/362 (45%), Gaps = 17/362 (4%) Query: 9 SEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD 68 S+P +G+E E +++ L+ + L+ + + + E++ + ++E+ + V D Sbjct: 4 SDPRKVGVEEEFHLIDLKTRRLTTRAPELLARLPDDVYVDELQ----QCVVEVNSGVYAD 59 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 ++ +++++ AA D + + G+ P V +RY R L ++ L + Sbjct: 60 LDGLRSDLERHRRLLVDAAEDLGIGVAAAGSVPLALPAEMHVTGTQRYGRMLADYQVLAR 119 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ-GTDTRFASSRPNIFS 187 + + G VHV D+A+ + H ++ +P +ALSA+SP+ G DT +AS+R ++ Sbjct: 120 EQLICGTQVHVDLPDRDEAVQVAHRVAPHMPVLLALSASSPFRSDGADTGYASARTLLWL 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP VS+ ++ AL L + +I ++D+RPS T+E+RV D+ L Sbjct: 180 RWPSTGPAAPVSSAAEYGALIDDLVASGVISDPGMAYFDVRPSVKLPTLELRVCDSCPRL 239 Query: 248 SHAVNMAGLIQATAHWLLTERPF-------KHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + +A L +A L ER K E L + ++A R GLE + D Sbjct: 240 DTVLLVAALFRA-----LVEREVEGLRAGRKGVEVLPTLTRAALWRAARSGLEEELVDVT 294 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 RP +E + + P + G + L + + + A R + G L Sbjct: 295 VPQARPASELVGDFVNSLRPQLEETGDWDRVVELSAEATAHGSSAARQRQALGRRGRLTD 354 Query: 361 LV 362 +V Sbjct: 355 VV 356 >UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YFK1_NOCDA Length = 390 Score = 107 bits (268), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 8/356 (2%) Query: 11 PFTLGIELEMQVVNP-PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 P T G+E E VV+P LS+ +L + ++ + + + + +E + VC D Sbjct: 27 PPTFGVEEEFFVVDPGTRLILSRAPEVLAN---TRVLGDHLCGEFSRAQVEANSPVCDDA 83 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 +A A + + +AA L + GT + RY +FG L + Sbjct: 84 GEALRFLRAARGELDRAAGAAGLAVVASGTAVLGDPASVGTSEGRRYADITAHFGALRES 143 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG + A+ + + L R++P +ALSA SP+ G DT ++S R ++ Sbjct: 144 HVVCGCHVHVGVPDRETAVAVGNHLRRWLPFLVALSANSPFHAGRDTGYSSWRTVAWNRL 203 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P GP P++ + + E R LS + I + ++WD+R S H T+E+RV D T Sbjct: 204 PSAGPPPFLRSLAEHEQAVRALSDSGAILDRRMVYWDVRLSDHLPTLEIRVSDVAATAEE 263 Query: 250 AVNMAGLIQATAHWLLTERPFKHQE---KDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 A+ +A L++ L + + D L + ++A R GLEGV+ DP TG+ P Sbjct: 264 ALLLALLVRGLTGRALADVLYGVPAPAIPDQAL-RAAVWRAARDGLEGVVPDPLTGEALP 322 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 RLL P G + +L +V + + A R A G L +V Sbjct: 323 GHAAAERLLHAAMPGLLANGDADLASSLLDRVRAAGSGAARQRAVYARRGRLADVV 378 >UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=Nocardiaceae RepID=CAAL3_RHOSR Length = 385 Score = 107 bits (267), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 95/357 (26%), Positives = 161/357 (45%), Gaps = 12/357 (3%) Query: 13 TLGIELEMQVVNP-PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+P G ++ ++ + IT ++ +++ +E AT + I Sbjct: 17 TLGVEEEFVLVDPHTGRPSLSNTDVIASGRELGIT---LQPELSRCQIETATSIGTHIRD 73 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 Q + V AA ++ GT P + D R++R E FG L Sbjct: 74 LRDQLCESRAVTADAAARTGCQLLAVGT-PMYSPPHDSITDTPRHRRIAEQFGAL-ATGV 131 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G HVHVG + AI +++ L ++P +AL+A SP G DT +AS R +F +P Sbjct: 132 MCGCHVHVGVPGREQAIQIINHLRPWLPTLLALTANSPIADGCDTGYASWRYILFGHWPS 191 Query: 192 NGPMPWVSNWQQFEA-LFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP P+ + ++A L + L ++D+ + + WD+R + H TVEVR+ D P T+ Sbjct: 192 AGPPPYFDSAAHYDAALAKMLESGAILDN-RMVFWDVRAADHPPTVEVRISDVPATVEET 250 Query: 251 VNMAGLIQA---TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 + + L+ A TA + ER D+ + ++A R GL G D T P Sbjct: 251 MTLTTLVHALVITAADAI-ERGTPAPTVDHEALRGACWRAARDGLSGHGFDLTTMGLIPA 309 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 +LL + P ++G + V+ N A R +A G + ++ + Sbjct: 310 PRLIYQLLTHVKPVLVELGECGQVTGSLAAVLEHGNGAIRQRRTLARHGRVADVIAE 366 >UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseudomonas RepID=CAAL_PSEE4 Length = 380 Score = 107 bits (266), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 3/291 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 ++ P+T GIE E + + + S + ++ ++ S +E+ + V Sbjct: 1 MARPWTFGIEEEYLLADTTSGQVLASPSPAVTRRCREMLGATFAEEMFLSQIEVVSPVFD 60 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 ++QA ++ + +A D + + G +HP +W RQ +++ +++ + Sbjct: 61 SLHQARSFLGENRQRLGEALGDFGVGLYGAASHPCAQWLRQHPRGTAHFRQLFDDYRLVA 120 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +++ V G HVHVG +G D + L++ + ++P F+ LS +SP G DT + S R I Sbjct: 121 RRSLVNGLHVHVGVPAGTDRMQLINRVLYWLPLFLVLSTSSPLWGGQDTGYMSYRRVICG 180 Query: 188 AFPDNG-PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P G P P +++W ++ L T + D W IRPS F TVE+R+ D Sbjct: 181 EWPHMGLPEP-LADWHAYQRYRGLLQRTGALAEDGDFWWAIRPSRRFPTVELRICDGCPR 239 Query: 247 LSHAVNMAGLIQ-ATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 L + +AGL + H L + + + N ++A RYG G Sbjct: 240 LEDGLAIAGLYRHLVQHALARHDGMAVSREIRWITQENYWRAARYGRRGTF 290 >UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xanthobacteraceae RepID=CAAL_AZOC5 Length = 386 Score = 106 bits (264), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 84/333 (25%), Positives = 145/333 (43%), Gaps = 10/333 (3%) Query: 5 DFHVSEPFTLGIELEMQVVNPP-GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 + +S + GIE E VV+ L + S DA+++++ + ++ +S LE+AT Sbjct: 11 EVRMSNDYRFGIEEEFFVVDAETKAALRRMPSGFFDALRDRL-GDSITVELLQSQLEMAT 69 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 I A + ++ + + A +H L GTHP W RY +++ Sbjct: 70 APTDRIGDALDELRDLRHIAGRVAAEHGLGFIAAGTHPTASWDNVRATKANRYDGLMQDL 129 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L ++ V G HVHV D + ++ ++ ++PHFIALS +SP+ T R Sbjct: 130 QMLGERNMVCGLHVHVELPDPDLRVDVMRRITPYLPHFIALSTSSPFWGSRQTGLMGYRL 189 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 + P G + +E L I + W IRPS T+E+R D Sbjct: 190 AAYDELPRTGLPELFEDNAAYEEYVAALVGARAISDSSYVWWAIRPSQKHPTLELRAPDA 249 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQE---KDYLLYKFNRFQACRYGLEGVITDPH 300 + AV +A L ++ +L+ P H+ D + N+++A RYG+ G D Sbjct: 250 CTRVEDAVALAALYRSLVRFLV-RHPEHHRHIGAVDRAIANENKWRAQRYGIHGSFVD-- 306 Query: 301 TGDRRPL-TEDTL-RLLEKIAPSAHKIGASSAI 331 ++R + D L +L+ +A A +G A+ Sbjct: 307 LAEQRAIQVRDALDQLIALVADDAEDLGCLDAL 339 >UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actinomycetales RepID=CAAL2_NOCSJ Length = 369 Score = 105 bits (262), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 78/265 (29%), Positives = 120/265 (45%), Gaps = 10/265 (3%) Query: 113 NERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 + RY R E FG + + G HVHV S +A+ +L + ++P +ALSA SP+ Q Sbjct: 107 SPRYDRMAERFGIVTDEQLTCGCHVHVAVGSTAEAVGVLDRIRVWLPALLALSANSPFWQ 166 Query: 173 GTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALF-RCLSYTTMIDSIKDLHWDIRPSP 231 G DT +AS R +P +GP ++ L R L+ ++D L++D R S Sbjct: 167 GRDTGYASFRIQALGRWPLSGPTELFGTAAAYQELVERVLAAQVVLDQ-GMLYFDARASH 225 Query: 232 HFGTVEVRVMDTPLTLSHAVNMAGLIQA-----TAHWLLTERPFKHQEKDYLLYKFNRFQ 286 F TVE+RV D L + V +A L +A A W E P + +L + + Sbjct: 226 RFPTVEIRVADVCLDVRDTVLIAALCRALVETSAARWAAGEAP---PQVPAVLLRLATWH 282 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 A R+G+ + DP T P E RL+E P+ + G + +++ N A Sbjct: 283 ASRWGVSADLLDPMTARPLPAAEVVGRLVEHARPALRRSGDDGLVADGIARILEHGNGAT 342 Query: 347 LMRDFVADGGSLIGLVKKHCEIWAG 371 RD A G L +V + +G Sbjct: 343 WQRDVFAGSGRLDEVVSALALVTSG 367 >UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RCL6_9ACTO Length = 372 Score = 105 bits (262), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 91/327 (27%), Positives = 141/327 (43%), Gaps = 8/327 (2%) Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 V +IT LE TD C + + A Q +KVV A L + GT P Sbjct: 49 VSGEITTLQLETRTDACGTLGELADQLDEARKVVADCARAAGLRVVATGTAPVAGAVPPP 108 Query: 110 VCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASP 169 + R R E + L + + HVHV A+ + + L ++P + L+A SP Sbjct: 109 MTVGPRQSRGTETYRGLHDELALCALHVHVEMPDRQRAVLVGNHLRPYLPLLLTLTANSP 168 Query: 170 YMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQF-EALFRCLSYTTMIDSIKDLHWDIR 228 Y D+ +AS R ++ +P GP P + + + E + R L ++D + WD+R Sbjct: 169 YWDDRDSGYASWRTTVWGRWPVAGPPPVFDSAEHYDEVVRRLLDAGALVDRAT-IFWDVR 227 Query: 229 PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQA----TAHWLLTERPFKHQEKDYLLYKFNR 284 PS T+EVRV D+ +T + A L++A A + P H + L + Sbjct: 228 PSERHPTLEVRVADSAVTAEDSARYAALVRALVVHLAAVMDAGEPAPHVAGE--LLRVGY 285 Query: 285 FQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNE 344 ++A R GL+G DP TG RP E LL+ + P G + ++ + Sbjct: 286 WRAARDGLDGEGLDPRTGRLRPAAELARHLLDTVEPVLRAHGDYDPVAQWLERLGTDGTG 345 Query: 345 AQLMRDFVADGGSLIGLVKKHCEIWAG 371 A+ R V GG+L +V E AG Sbjct: 346 ARHQRAVVRRGGTLTDVVDHLAERTAG 372 >UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromonospora RepID=C4RQD7_9ACTO Length = 382 Score = 105 bits (262), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 89/356 (25%), Positives = 164/356 (46%), Gaps = 8/356 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 FT+G+E E +V+P ++++ V ++ G+V+ + S +E+ + +++ Sbjct: 23 FTVGVEEEFLLVDPHTGTAVPAVDLVMEQVPAELR-GQVEREFQTSQIEIGSPPGLELSS 81 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 +++ + AA + + GT P V D R+ R +E F L+ Sbjct: 82 IRHSLGVLRRALADAAERAGVRVLAIGTGPVDG-PVPPVVDKPRFDRMIERFRLLVPGPG 140 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 G HVHVG + + +L+ + ++P A++ SP+ G DT +AS R + +P Sbjct: 141 NNGMHVHVGVPDPETGVRVLNHVRPWLPILHAVTTNSPFFAGEDTGYASWRSVEWERWPS 200 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 P P++ + + +E L R L + ++ L+W R S + TVE+R+ D ++ AV Sbjct: 201 VAPTPYLESHEHYERLIRQLIASGVMLDEGMLYWYARLSAKYPTVEIRIGDVCPSVDDAV 260 Query: 252 NMAGLIQATAHWLLTE----RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 +A L++A +T+ RP D+ L ++A GLEG D G+ RP Sbjct: 261 LVAALVRALVATAMTDIAEGRP--PIRTDHHLLVAAHWRAAHDGLEGQCVDLTDGELRPG 318 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 E L+E++ P+ + G + + L + A R A GSL+ +V+ Sbjct: 319 WERLDSLVERLGPALERHGDLAEVTDLLGGLRRHGTGAARQRAVFARTGSLVDVVR 374 >UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Mycobacterium RepID=CAAL3_MYCS2 Length = 365 Score = 104 bits (259), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 86/340 (25%), Positives = 158/340 (46%), Gaps = 14/340 (4%) Query: 13 TLGIELEMQVVNP-PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G+E E +V+P G ++++ ++ A + +++ ++T +E AT+V + + Sbjct: 6 TFGVEEEFLLVDPRTGEPIARNKAVAETAAAKGV---DLQLELTSCQVETATEVMDNSDD 62 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 +++V AA + + G P + + RY+R FG + + Sbjct: 63 LRKALLRLRRVATDAAETNGARLLAAGLPPTVP-HKFPITPTPRYRRIGHRFGMIAHEQG 121 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G HVHV S D AI + + L ++ +AL+A S +G+D+ +A+ R +++ +P Sbjct: 122 ICGCHVHVEVPSRDAAIRVSNRLRPWLHLLLALTANSAIYRGSDSGYATFRSVLWARWPS 181 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P+ + Q++A L ++WD+RPS F TVEVRV D P T++ V Sbjct: 182 AGPPPFFDSEAQYDATVAMLEDAGAALDDGMIYWDVRPSNKFPTVEVRVSDVPATVAETV 241 Query: 252 NMAGLIQATAHWLLTERPFKHQE-----KDYLLYKFNRFQACRYGLEGVITD-PHTGDRR 305 A L++A + K+ E DY+L K +++ R GL+G D + Sbjct: 242 LFATLVRAAV--MTATEAEKNGEPVVPLTDYVL-KAAYWKSARDGLDGRTIDLAESHAVA 298 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEA 345 P E +E + P+ ++G + +V+ N A Sbjct: 299 PTVELLTNFVEHLRPALEQLGEYDTVRGELARVIETGNGA 338 >UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rhodococcus RepID=CAAL1_RHOSR Length = 369 Score = 103 bits (256), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 77/315 (24%), Positives = 143/315 (45%), Gaps = 13/315 (4%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 ++G+E E +V+ G+ LS ++ + I ++ ++ +E AT VC + Sbjct: 12 LSVGVEEEFFLVDESGH-LSAAGPDVVTEAGHDIHG--LQRELARCQIETATGVCHTGEE 68 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++++ + +AA L + GT + + + RY+ +FG ++ T Sbjct: 69 LHEELRSLRRRLAKAAAGRDLLLLPSGTSLVVEGLPPAITPSPRYEEMARHFGSIVDTVT 128 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 G HVHVG S D + + + + ++P +AL+A SP+ G DT + S R ++S +P Sbjct: 129 TCGCHVHVGIPSRDVGVRVSNLVRSWLPVLLALAANSPFHSGHDTAYHSWRHIMWSRWPS 188 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P + ++EA + T ++W +R + T+EVR+ D +T +HA Sbjct: 189 AGPPPHFDSADEYEATVGAMIGTGAAMDRGMIYWHVRLADKQPTIEVRIADVAMTAAHAA 248 Query: 252 NMAGLIQATAHWLLTER------PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 A +++ W L P+ E L + ++A R GL+G T P Sbjct: 249 LYAVVVKGLVGWALQSLDDGLTVPWLRAE----LLRAQLWRAARDGLDGECTSPAADRVL 304 Query: 306 PLTEDTLRLLEKIAP 320 P+ L + +AP Sbjct: 305 PIRRQLELLNDCVAP 319 >UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax=Streptomyces RepID=C9YX80_STRSW Length = 375 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 75/320 (23%), Positives = 144/320 (45%), Gaps = 3/320 (0%) Query: 40 AVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 A+ ++ E K ++ S +E + V + + ++ + AA+ L + GT Sbjct: 6 AILGRLGGPEFKAELQRSAVEWNSPVHASLESLHTDLTGARRRLAAAASGLGLSVVAAGT 65 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 P + + + RY+ E + + + V VHV D A+ ++ +S ++P Sbjct: 66 VPLARLTPGDTTPDFRYRYMTEEYRRVADEHLVCSAQVHVDVPDRDTAVRIMCAVSPWLP 125 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 +AL+A+SP+ G DT +AS R ++ +P GP+ + +++A + L + +I Sbjct: 126 PLLALTASSPFWLGADTGYASWRTMLWQRWPTAGPVGCFAGAAEYDAAVQGLIRSGVIKD 185 Query: 220 IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQAT---AHWLLTERPFKHQEKD 276 +++D+RPS H T+E+R+ D V + GL +A A LL P + E Sbjct: 186 SGMVYYDLRPSEHQRTLELRICDASPRPETVVLVTGLFRALVEDARGLLEREPERVCEGG 245 Query: 277 YLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHR 336 + + ++A R GLEG + DP T P +L ++ P+ G + L Sbjct: 246 HEWLRSAVWRAARSGLEGDLVDPVTRGAAPAPAVLRGMLRRLRPALEAAGDWDTVPVLLE 305 Query: 337 QVVSGLNEAQLMRDFVADGG 356 + ++ + A +R + G Sbjct: 306 EALARGSAAHRLRRVAGERG 325 >UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PXZ1_9ACTO Length = 351 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 89/353 (25%), Positives = 161/353 (45%), Gaps = 11/353 (3%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 ++G+E E+ +V+ G L + AVK + +V+ ++T + +E+ VC ++ Sbjct: 5 SMGVEEELLLVSASGEPLPRSK-----AVKEEAEGVDVELELTRAQVEINAPVCDSSDEL 59 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 + + AA + + P + Q V RYQ +G L ++ V Sbjct: 60 RRHLVDGRTKLAAAAAEEGARLLAVAAPPSGQ-ALQLVTKKPRYQEMEARYGQLAREQGV 118 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVH+ A+ + + L ++P +AL+A S G DT F+S R ++S +P Sbjct: 119 CGCHVHIDVPDKAAALRVSNHLRPWLPALLALTANSAVYLGEDTGFSSWRWIMWSRWPCA 178 Query: 193 GPMPWVSNWQQFEALFRC-LSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P+ + + ++ L R L+ +++D + ++WD RPS H T+EVRV D PLT+ V Sbjct: 179 GQPPYFESVEHYDRLVRTHLAAGSIMDE-RMVYWDARPSTHLPTLEVRVSDVPLTVDETV 237 Query: 252 NMAGLIQATAHWLLTE-RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 +A L +A L + P + + L + + A R GL G D P+ + Sbjct: 238 LIATLSRALVMTALADGGPGPELQPEVLRAAY--WLAARDGLTGDSVDVLNAQPMPMVDV 295 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 L E + P+ ++G +E ++++ N A R + G + L + Sbjct: 296 QKLLREHVQPALEELGDLELVEETTERLLTDGNGAVRQRRAFRESGDVTALAE 348 >UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alphaproteobacteria RepID=CAAL_BRASB Length = 408 Score = 101 bits (251), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 77/356 (21%), Positives = 155/356 (43%), Gaps = 8/356 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 ++ GIE E + + D++ + + N T G+ ++ ++ +E+AT+V D Sbjct: 34 YSFGIEEEYFLADARTLDVAIRTPDDLFEAANWSTGGQAMREMLQAQIEVATNVHVDSRD 93 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A + +++ V A + L I THP W+ + RY +E+ + Q+ Sbjct: 94 AREELKFLRREVASVAGQYGLTILACSTHPTAMWRSSQPTPRPRYAEMMEDLRIVGQRNM 153 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G HVHV + ++ + ++P FIALSA+SP+ +T R + P Sbjct: 154 LCGMHVHVQLPDSERRFAVMRAMIPYIPVFIALSASSPFWNSRETGLKGYRLAAYDELPR 213 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G ++ +++ L+ + ++ + W +RPS T+E+R D ++ AV Sbjct: 214 TGLPELFTSKPEYDRYVAALTRSGVMPDESHVWWAMRPSLRHPTLELRAPDVCTSVDDAV 273 Query: 252 NMAGLIQATAHWLLTERPFKHQ--EKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A L +A A L + + N+++A RYG + + + P+T Sbjct: 274 AVASLYRALARHLYLHPDLADAVGNVERAIAVENKWRAQRYGTDCLF----VAEEGPVTG 329 Query: 310 DTL--RLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 + R++ IAP A + + +E + G + ++ + GG L +++ Sbjct: 330 QEILNRMIADIAPHAEALDCLAEVERCRTIMQFGSSADYQLQAYRESGGELSAVLR 385 >UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0LDX8_GORB4 Length = 374 Score = 99.8 bits (247), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 97/355 (27%), Positives = 162/355 (45%), Gaps = 8/355 (2%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 PD V P T+G+E E +V+P + ++++ + A + + +++ ++T +E A Sbjct: 9 PDALVVAP-TVGVEEEFILVDPATEHPVARNGEVAAAASRRGV---DLELELTSCQVETA 64 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 T + + + ++ VV AA + + + G P + D RY+R E Sbjct: 65 TAPHHAVADLLDELTRLRSVVAAAAAEVGVGVIAAGAPPTVPVA-FPITDTARYRRIGER 123 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 FG L + V G HVHV + AI + + L +P +ALSA SP + DT AS R Sbjct: 124 FGMLAHEQGVCGCHVHVAVPDRETAIEVSNHLRHRLPVLLALSANSPVYRDADTGHASWR 183 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 ++S +P GP P + + + FE+L + I ++WD+RPS H T+EVRV D Sbjct: 184 WVLWSRWPAAGPPPHLRSREHFESLVTMFVASGAILDDHMVYWDVRPSDHLPTIEVRVGD 243 Query: 243 TPLTLSHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 T S A A +++ L + E D + ++A G++G D Sbjct: 244 VQPTASEAAAFAAIVRGLTLTALRDIDAGIAAPEIDTAILDAAMWKAAHDGIDGAGIDVL 303 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 TG+ P + RL++ I+ + G + + A R + S N A R DG Sbjct: 304 TGESVPALDLVGRLVDDISDALDAAGDADLVTAARRSLGSRGNGATRRRRDFRDG 358 >UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WJM5_ACTMD Length = 383 Score = 97.8 bits (242), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 88/312 (28%), Positives = 133/312 (42%), Gaps = 6/312 (1%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G+E E +V+P + + ++ AV++ + ++ S +E AT VCR + Sbjct: 5 TFGVEEEYLLVSPETSLPTASAPEVLAAVRDLPPGAMAQPELLSSQVEFATGVCRTAPEL 64 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 Q A + V AA + G P R V RY+ + L+ Sbjct: 65 REQLRAGRSAVADAAGRVGVLPVAVGNPPLPG--RVPVTRGSRYREITSLYQGLMTDYQC 122 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + +L L ++P +ALS SP+ +G DT + S R S+FP Sbjct: 123 CGCHVHVGVPDRATGVAVLDHLRPWLPTLLALSVNSPFDRGEDTGYGSWRAVRQSSFPGW 182 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G P + ++ + L T ++ W R SP + TVEVR DT T+ AV Sbjct: 183 GVPPLLRTVERHDRLVEAAVDTGVLVDPTMTFWLARLSPKYPTVEVRAADTAATVDGAVL 242 Query: 253 MAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 A L +A L ER + + + + + A R+G G DP TG R ED Sbjct: 243 QAVLTRALVDTALAALERGEEAPDHEPAVLTAALWSAARHGTAGQGVDPTTG-RAVRAED 301 Query: 311 TLR-LLEKIAPS 321 R LL + P+ Sbjct: 302 LARALLAHVRPA 313 >UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salinispora RepID=CAAL_SALAI Length = 378 Score = 97.4 bits (241), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 79/317 (24%), Positives = 137/317 (43%), Gaps = 4/317 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++ + ++ ++D + + + + + SM+E+ T V D+ + Sbjct: 15 LTLGVEEEFLLLDAETGESMPVAARVLDGLSG-VAHAQSRREFRHSMVEMVTPVLSDLAE 73 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A++ AA + G P + R V D RY FG + Sbjct: 74 LRRHLVALRTAAADAAEAAGARLVAVGATPVNETHRT-VPDEPRYHAMSRRFGPVAHDPA 132 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + + L ++P A++A SP G DT AS R +P Sbjct: 133 VCGCHVHVGLPDRELAVQVCNHLRPWLPVVQAITANSPLHDGQDTGHASWRAMQLERWPS 192 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P+ + ++A L ++ ++W +RPS + TVE+RV D T+ V Sbjct: 193 IGPTPYFDSAADYDATVADLIKAGIMLDAGMVYWYVRPSAAYPTVEIRVGDVCPTVDDTV 252 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +AGL++A + + + L ++A GL+G + D TG RP + Sbjct: 253 LVAGLVRALVATVAADVHDGARAPRIRGCLLSAAHWRAAHDGLDGDLVDLRTGRARPAWD 312 Query: 310 DTLRLLEKIAPSAHKIG 326 L + P+ + G Sbjct: 313 LVDDLFALVTPALERQG 329 >UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2Q2P1_9ACTO Length = 333 Score = 97.1 bits (240), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 113/276 (40%), Gaps = 4/276 (1%) Query: 49 EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 VK ++ LE+AT V RD+ A + +++V A L + HP + Sbjct: 23 RVKPELPACQLEIATSVHRDVADAVAELRTCRELVATACAPD-LALVAAPVHPLVE-GPT 80 Query: 109 EVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAAS 168 + E + +I + V VH+ D + + H L +P AL+A + Sbjct: 81 ALSPTEHAAGLSARYRDVISRQLVSSLQVHLAFGDADCTLSVYHALRDLLPELTALAACA 140 Query: 169 PYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIR 228 P+ G D S RP + S P G P +++W Q+ + + + W++R Sbjct: 141 PFTAGRDAGLCSVRPVVASQLPRQGVPPIITSWHQYAEDLNWAVQGGAVANASEWWWELR 200 Query: 229 PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF--NRFQ 286 P +GT+E+RV+D T + +A + A L E ++ NR+ Sbjct: 201 PHLRYGTLELRVLDVQATTAQTSAIARFVHALGARLADLHHLGRLEPPAPTWRIAENRWS 260 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSA 322 A R G+ G + D TG+ RP L++ P A Sbjct: 261 ALRDGVRGELLDLRTGEVRPTRRRLHHLIDTTEPYA 296 >UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D2S6F8_9ACTO Length = 386 Score = 97.1 bits (240), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 83/326 (25%), Positives = 130/326 (39%), Gaps = 12/326 (3%) Query: 48 GEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 G + ++ LE T VC ++ A + AA D + + P + Sbjct: 63 GRLVPELKTQQLEFGTRVCTGLDDVAADLRHWRGRADAAARDVGARVAALASSPVRV--E 120 Query: 108 QEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAA 167 + ERY E F + G HVHV ++ + +L+ + ++P AL+A Sbjct: 121 PQSTPGERYTEMAETFRLTAAEQLTCGCHVHVAVEDDEEGVAVLNRIRVWLPVLTALTAN 180 Query: 168 SPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDI 227 SP+ G D+ AS R ++ +P +GP ++ + L L T I +++D Sbjct: 181 SPFWLGRDSGHASYRAQAWNRWPSSGPNELFADAAAYHRLVGELLATETIVDTGMVYFDA 240 Query: 228 RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ-----ATAHWLL-TERPFKHQEKDYLLYK 281 R S + TVEVRV D L AV +AGL++ A W P E + + Sbjct: 241 RLSERWPTVEVRVADVALRAEDAVTLAGLVRGLVETAAGQWRAGVPAPAVRSE----VVR 296 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 ++A R GL G + P TG P LL + P+ G + A V+ Sbjct: 297 MAAWRASRSGLTGDLVHPATGRPAPAGAVVTALLAHVRPALAAAGDEQRVAAGVAAVLDR 356 Query: 342 LNEAQLMRDFVADGGSLIGLVKKHCE 367 A L R A G L +V+ E Sbjct: 357 GTGADLQRRVFAATGDLTAVVRAAVE 382 >UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1AAX9_THECD Length = 371 Score = 96.7 bits (239), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/362 (23%), Positives = 159/362 (43%), Gaps = 16/362 (4%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVK--------NKITAGEVKHDITESMLELATD 64 + G+E E+ + +P G S ++ + + +T G ++ ++ LE+ T Sbjct: 5 SFGVEEELLLFDPEGGAPRAMSGAVLHHARLQGEKVHTSPLTKGGMESELQREQLEICTR 64 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 C +++ Q + +AA + I T P + ++RY++ + + Sbjct: 65 PCTTLDELDRQVRRRRLAAARAAAAAGVRIAALATSPVAA--HPTLTPHDRYRQMADQYA 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 + + + G HVHV +S ++ + +L + ++P +ALSA SP+ QG DT + S R Sbjct: 123 QVADEQLICGCHVHVEVSSPEEGVGVLDRIGPWLPPLLALSANSPFWQGRDTGYDSWRRQ 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +++ +P +GP + + R L T + +++D R S H+ TVEVRV D Sbjct: 183 VWARWPSSGPAEPFRSADGYRRAVRALIETGALLDEGMVYYDARLSRHYPTVEVRVADVC 242 Query: 245 LTLSHAVNMA----GLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + V +A GL++ A RP + L + ++A R GL G + P Sbjct: 243 MRADDTVLIAALVRGLVETAARAHREGRPPVPVRTEVL--RAAMWRAGRSGLSGALVHPV 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 T P L+E + P+ G +A+ L + + N A L R A G + G Sbjct: 301 TWRPAPARTVLQALVEYLRPALEDAGDLAAVRELLQALARRGNGACLQRTAYARTGCISG 360 Query: 361 LV 362 ++ Sbjct: 361 VI 362 >UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocardioides sp. JS614 RepID=CAAL1_NOCSJ Length = 382 Score = 95.9 bits (237), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 87/363 (23%), Positives = 157/363 (43%), Gaps = 20/363 (5%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKN--------KITAGEVKHDITESMLELATDV 65 LGIE E+ + +P ++ + ++ + + E+ ++ LE TD Sbjct: 5 LGIEEELLLFDPESGEVVPAAPSVLKEFREHGPGRQRARAATDELDQELFRHQLETRTDP 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 R A Q A ++ +AA G P R V N+RY+ ++ +G Sbjct: 65 VRRAADALDQLVAARRTAGEAARAAGYAAGACGIVPLGG-DRSVVSPNDRYRDMVDTYGE 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + + G HVHV S ++ + ++ ++ ++P +AL+A SPY++G D+ +AS R + Sbjct: 124 IARTGGTCGMHVHVDIGSDEEGVAVVDRIAPWLPVLVALAANSPYVEGRDSGYASWRAQV 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 ++ +P GP + + + R L L++D R S TVEVRV D Sbjct: 184 WARWPSAGPTEQFGSVAGYREVCRMLLDVGAARDPGMLYFDARLSTGQPTVEVRVCDVGT 243 Query: 246 TLSHAVNMAGLIQATAHWLLTE----RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 + AV + L++A E RP H + L + ++A R+G+ + P Sbjct: 244 DPAVAVTIGALVRALVETAAEEWADGRPAAHWRAEAL--RAAHWRASRFGMADSLVHPLA 301 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA--DGGSLI 359 RP L+E + P+ + A+ +E + Q+ +N+ R A GS+ Sbjct: 302 RGLRPARSVVAALVEAVEPA---LAAAGDLELVDVQLERAVNDNGATRQRAAFERTGSVR 358 Query: 360 GLV 362 G+V Sbjct: 359 GVV 361 >UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SDE2_9ACTO Length = 380 Score = 95.1 bits (235), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 84/321 (26%), Positives = 145/321 (45%), Gaps = 12/321 (3%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG---EVKHDITESMLELATDVCRD 68 TLG+E E +++P + +S + D V+ ++ + + + SM+E+ T V D Sbjct: 19 LTLGVEEEFLLLDP----ATGESMPVADRVRGALSGTAREQSRQEFRHSMVEMVTPVSPD 74 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 + + +++ QAA + G P + R V D +RY FG + Sbjct: 75 LGELREHLVTLRQAAAQAADAAGARLVAVGATPVCEAHRT-VPDEQRYHDMSRRFGPVAH 133 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 V G HVHVG + A+ + + L ++P AL+A SP G DT AS R Sbjct: 134 DPAVCGCHVHVGVPDRELAVQVCNHLRPWLPVVQALTANSPLHDGRDTGHASWRSMQLER 193 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLS 248 +P GP P + ++A L ++ ++W RPS + TVEVRV D T+ Sbjct: 194 WPSIGPTPHFESAADYDATVADLITAGIMLDAAMVYWYARPSAAYPTVEVRVGDVCPTVD 253 Query: 249 HAVNMAGLIQATAHWLLTERPF---KHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 V +AGL++A L+ + + +D L+ + ++A G++G + D +G R Sbjct: 254 DTVLVAGLVRALVATLIDDVRAGVPAPRIRDCLVAAAH-WRAAHDGVDGKLVDLRSGRPR 312 Query: 306 PLTEDTLRLLEKIAPSAHKIG 326 P + L+ + P+ + G Sbjct: 313 PAWDLVDDLVVTVTPALARHG 333 >UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=Actinomycetales RepID=CAAL2_FRASC Length = 861 Score = 94.7 bits (234), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 74/320 (23%), Positives = 141/320 (44%), Gaps = 2/320 (0%) Query: 41 VKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTH 100 V ++ ++ +S++E + D+ + +++ + + + L GT Sbjct: 32 VLRRLDGDSFSPELLKSVVETNSQPTADLLELRTNLLDLRRRLAEVTGELGLGPAAAGTV 91 Query: 101 PFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPH 160 P +V ++RY++ E++ + ++ + G VHV A D A+ ++ + ++P Sbjct: 92 PIVDMDLLDVSRDDRYEQMTEDYQIVAREQLICGAQVHVDVADRDLAMAVVAWTAPWLPM 151 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSI 220 +ALSA+SP+ G D+ +AS R ++ +P G +++ L L + +I Sbjct: 152 LLALSASSPFWMGADSGYASMRTLVWQRWPTAGVAGSFRTAAEYDQLVADLIKSGVISDP 211 Query: 221 KDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQE--KDYL 278 +++D+RPS H TVE+R+ D + + + +AGL +A + E Q Sbjct: 212 GMVYFDVRPSAHLPTVELRICDACPDVDNVILIAGLFRALVCQAIEEIEAGGQAPPPRAE 271 Query: 279 LYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQV 338 L + ++A R GLEG + D P RLL ++ P + I+ L Q Sbjct: 272 LLRAATWRAARSGLEGDLVDILGAGPIPAQAMLRRLLTEVRPQLERFDDWELIDNLAEQA 331 Query: 339 VSGLNEAQLMRDFVADGGSL 358 V + A R A G L Sbjct: 332 VGRGSSAHRQRRAFARRGLL 351 >UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GH73_KOCRD Length = 378 Score = 94.4 bits (233), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 131/310 (42%), Gaps = 9/310 (2%) Query: 13 TLGIELEMQVVNP----PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD 68 T GIE E +++ P + S+ L V + G + +E + + D Sbjct: 18 TFGIEEEFLLIDRGDRLPARPTPEQSAQL---VSLEAGGGSATPEWLACQVEETSPIFHD 74 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 A + + A +++ G P + + ++ NERYQR + Sbjct: 75 AAGAVDSLVTFRTALHDATDAMGMDVVGLAAAPDIRPEPADITVNERYQRLAGYTPAVAA 134 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 + G HVH+G +DA+ L+GL ++P +A+ A SP +G ++ F S R + Sbjct: 135 DQYISGMHVHLGFPDMEDAVRALNGLRGWLPALVAIGANSPLWRGAESGFESWRSIHYRR 194 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLS 248 + N P + E LS +++S L W R S GT+E+R D L Sbjct: 195 WIANDIPPHFKDLADHEQRVAVLSAFDVMESPSTLSWLARLSHKHGTLEIRACDVQLEAQ 254 Query: 249 HAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 +V +A LI+A A + + P ++YL +QA R+GL G + DP + P Sbjct: 255 DSVAIAVLIRALADYAMDVPPTMEFSQEYL--DIALWQAARWGLSGRVLDPVAAELVPGE 312 Query: 309 EDTLRLLEKI 318 LLE++ Sbjct: 313 ALVTDLLERV 322 >UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces RepID=B4V462_9ACTO Length = 381 Score = 94.4 bits (233), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 86/318 (27%), Positives = 143/318 (44%), Gaps = 17/318 (5%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDI----TESMLELATDVC 66 P T+G+E E +V+ + + +++D TA + H++ T +E++T V Sbjct: 19 PLTVGVEEEFLLVDTRTLRVVPAAPLVLD------TAAGLPHELHPEGTRYQVEISTPVA 72 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL-ENFGY 125 + +A+++ + +AA H + + + D+E QR FG Sbjct: 73 HSAVTLRAELAALRRTLARAARAHGCRLLAAPSPVVALEGPLHLTDDEPRQREQHRRFGA 132 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L G+HVH+G D A+ + + + ++P IAL+A SP+ G DT AS R Sbjct: 133 LTDTLVSCGRHVHIGTLDVDTAVAVSNRVRPWLPTLIALAANSPFWGGRDTGHASWRAMA 192 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 ++ +P G P ++ F + L + K ++WD+RPS H+ T+E+R D Sbjct: 193 WAGWPSAGLPPHFTSTAHFRRSVQNLLGSGAALDTKMVYWDLRPSGHWPTLEIRAPDMSP 252 Query: 246 TLSHAVNMAGLIQATAHWLLTE----RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 + AV A L +A L E RP D L + R++A GLEG DP+T Sbjct: 253 DIDTAVLQAELARALVAKALQEISEHRPEPAIRDDVL--RLARWRAAHDGLEGFGLDPYT 310 Query: 302 GDRRPLTEDTLRLLEKIA 319 G P LL+ +A Sbjct: 311 GAELPAAGLAEALLDHVA 328 >UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyces RepID=B4V111_9ACTO Length = 391 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 66/202 (32%), Positives = 97/202 (48%), Gaps = 7/202 (3%) Query: 110 VCDNERYQRTLENFGYLI--QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAA 167 V D RY+R FG L+ V G HVHVG A A++L + + ++P AL+ Sbjct: 124 VTDTPRYRRMARQFGALVDGNLGIVCGCHVHVGAADRAQALFLANHVRPWLPALQALAVN 183 Query: 168 SPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDI 227 SP+ G DT FAS R F +P P P + + E+ + ++D + ++W Sbjct: 184 SPFAGGVDTGFASWRCVEFGRWPTAEPSPLLDSASYEESASALVDSGILMDR-RMIYWFA 242 Query: 228 RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN---R 284 RPS H TVE RV DT L V +A L++ LL + + D + + R Sbjct: 243 RPSEHHPTVEFRVADTNADLDTTVLVALLLRGLCATLLAQAEERRPPPDAPVPRLRDAHR 302 Query: 285 FQACRYGLEGVITDPHTGDRRP 306 + A +YG G+ DP TG+R P Sbjct: 303 Y-AAQYGPTGLALDPFTGERVP 323 >UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Streptomyces RepID=CAAL_STRCO Length = 363 Score = 87.8 bits (216), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 87/356 (24%), Positives = 156/356 (43%), Gaps = 11/356 (3%) Query: 13 TLGIELEMQVVNPP-GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T+G+E E+ +V+P G + +++L A + + ++ E MLE AT D+ + Sbjct: 3 TVGVEEELLLVDPATGEPRALSAAVLARAFLDDSEQDVFEKELHEQMLEFATHPQADMER 62 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++ + A + T P + N RY+ E +G ++ + Sbjct: 63 LHAEIVRCREEAGRHAGGIGCAVAALATSPLPV--TPSIGVNRRYEWMAEQYGVVVHEQL 120 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHV S ++ + ++ + ++P ALSA SP+ QG D+ ++S R ++ +P Sbjct: 121 VLGCHVHVSVDSDEEGVAVIDRVRPWLPVLAALSANSPFWQGRDSSYSSYRSRVWQRWPS 180 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP + +++ + T + +++D+R S + TVE RV D L S AV Sbjct: 181 AGPTELFGSAERYHRRVADMLATGTVLDDGMVYFDVRLSQRYPTVEFRVADVCLDASTAV 240 Query: 252 NMAGLIQ-----ATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 +A L + A W P +H L + ++A R GL + P T R P Sbjct: 241 VLAALARALVDTAAREWRAGAEPAEHSVS---LLRLAAWRAARSGLTSELLHPATMRRMP 297 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 LLE + G + +++ N A++ R+ +A GSL +V Sbjct: 298 AESVVRDLLEHAGEALAAAGDLERVREGVEKLLRHGNGARVQRELLARTGSLREVV 353 >UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudomonas fluorescens Pf-5 RepID=CAAL_PSEF5 Length = 387 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/291 (23%), Positives = 124/291 (42%), Gaps = 2/291 (0%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F +P LGIE E + + + + + + +++ + +E+A+ V Sbjct: 4 FDPGQPQHLGIEEEYLLTDLQSRCMVAEPPPEVLRDCREALGQNFAYEMFQGQIEVASPV 63 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 QA ++ + QA H L G+HP W Q +++ F Sbjct: 64 FDHSAQAGAYLRQVRSALDQALASHGLGFICAGSHPLADWHEQRATPQAHFRQLFNEFAL 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 +++ + G HVH + D I +++ + + P +ALS +SP+ QG D+ + S R Sbjct: 124 AARRSVLSGLHVHAQVPAAVDRIAVMNEVLPWTPLLLALSLSSPFWQGHDSGYLSYRQVA 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 +P G ++ + Q F+ R L + + + W IRP+ + T+E+R+ D Sbjct: 184 CDEWPRMGIPEYLHDHQAFDDYLRLLRGIGALGAEDNAWWGIRPALRYPTLELRMTDACP 243 Query: 246 TLSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 ++ A +AGL LL ++ + L K NR QA R G +G Sbjct: 244 RVADAQTLAGLFAVMVRHACLLPAAGSQYTQAQRWLLKENRVQARRRGAQG 294 >UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphaproteobacteria RepID=B1M5M5_METRJ Length = 388 Score = 82.8 bits (203), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 99/219 (45%), Gaps = 2/219 (0%) Query: 40 AVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 AV+ ++ + + + + +E+A+ D+ +A + ++ + + + + GT Sbjct: 34 AVRGRLD--DAEREQLQCQVEVASPPTADLAEARAHLADLRASLAEIGGERGILTFAAGT 91 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 HP +W+ Q D RY + + L ++ V G HVHV I L++ L ++P Sbjct: 92 HPTARWRDQRPTDKARYHGIMADLRMLGRRNLVCGLHVHVEVPDPAARIGLINRLLPYLP 151 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 +ALS SP+ QG T A R ++ P G ++ + ++ + I Sbjct: 152 VLLALSTGSPFWQGQQTGLAGYRMRAYAELPRTGVPELFADADDYARYVDVMTRSGAIAD 211 Query: 220 IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 L W +R S + T+E+R+ D+ L A+ +A L + Sbjct: 212 ASYLWWHVRASVKYPTLELRIADSCARLDDALCIAALFR 250 >UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthrobacter RepID=CAAL3_ARTAT Length = 424 Score = 81.3 bits (199), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 72/288 (25%), Positives = 122/288 (42%), Gaps = 6/288 (2%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G+E E+ +V+P + + L+ +++ T+G + H++ +E T C + Sbjct: 31 TFGVEEELLIVDPVTGEPLALADALLAG-QDEPTSG-LSHELKLEQIETQTRPCHSYGEL 88 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 Q + + QAA H + T P + RY L+ FG + + Sbjct: 89 LQQIRRGRAMANQAARQHGARVAAIATSPLAS--NTHTTPDPRYAAMLDRFGIIATEQLT 146 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVH S ++ + +L + + AL+A SPY +G T F S R ++ +P + Sbjct: 147 CGFHVHTSVESPEEGVVVLDHIRDKLAVLTALTANSPYWRGLPTGFDSYRTQAWNRWPTS 206 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 GP + + + + L T +I +++D R S + TVEVRV D L A Sbjct: 207 GPSSVFGSLTAYRRIVKRLLETGVIMDEGMIYFDARISRNHPTVEVRVADVCLRAEDAAL 266 Query: 253 MAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 MA L++A E + L + +QA GL G + D Sbjct: 267 MAVLVRALVETASLEMLDGVEPTAVPTALLRMASWQASNSGLRGDLLD 314 >UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseudomonas aeruginosa RepID=CAAL_PSEAB Length = 404 Score = 80.9 bits (198), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 121/283 (42%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 GIE E +++ D+ + + A ++ E +E+A+ V + + Sbjct: 10 LRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTLAE 69 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 AA ++ + A D L GTHPF W+R + R E+ G + +++ Sbjct: 70 AARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARRSL 129 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHV D + +L + ++P +ALSA+SP+ G + AS R + +P Sbjct: 130 VCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEWPR 189 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 P + + + L I + W IRPS H T+E+R+ D L+ A+ Sbjct: 190 MNIPPALPDEDAYRRHLALLREAGCIREDGQVWWMIRPSSHVPTLELRICDACPRLADAL 249 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 ++AGL +A L P + N +QA RYG G Sbjct: 250 SLAGLFRALVGEALGAGPRTLPVARDACLEENYWQALRYGCAG 292 >UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylobacterium RepID=B0UDI3_METS4 Length = 377 Score = 80.1 bits (196), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/295 (22%), Positives = 122/295 (41%), Gaps = 10/295 (3%) Query: 51 KHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR--- 107 +HD+ E L +T D+ +A A++ + A L + GTHP W R Sbjct: 43 RHDLIEPRLIWSTPPVADLAEARRALEALRGGIGALAAARGLTVMAAGTHPIALWSRVRP 102 Query: 108 QEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAA 167 ++ +R QR L+ G + V G + VG G I +++ + F+P +ALS + Sbjct: 103 RDAAARDRVQRDLQMVG---SRTVVCGLSIRVGLPEGVSRIDVMNRIQPFLPLILALSTS 159 Query: 168 SPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDI 227 SP+ Q T R P +G P+ + L I + + W I Sbjct: 160 SPFWQAQRTGLMGYRLAASRELPRSGLPPYFRDEDDHARYLAALMRAGAIADLAHVWWVI 219 Query: 228 RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQ--EKDYLLYKFNRF 285 RP+ +++R+ D+ L + +A L + L + + + + N + Sbjct: 220 RPAGEAHALDLRIADSCTRLDDTLAIAALTRCLVRRLARDPSLQRDLTGATHAITAENCW 279 Query: 286 QACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS 340 +A R G+ G + +G+ P+ R L +A +G ++ ++ L R +V+ Sbjct: 280 RAQRSGIHGSLMT-ESGEAEPVPALLSRTLALVAEDGAALGCTAELD-LARWIVA 332 >UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1BT73_XYLCX Length = 357 Score = 77.0 bits (188), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 126/293 (43%), Gaps = 13/293 (4%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E E+ ++ G + +L A G ++++ E LE AT+ R + + A Sbjct: 1 MGVEEELLLLGHDGSPAPRAQEVLEGADAGD---GPLENEFMEEQLETATEPARSLTELA 57 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 + +AA + T P RY R FG + Sbjct: 58 DALRTGRAGAREAAARQDALVAALATSPVAF--TGTTVSRLRYLRARSAFGITAWEQLTN 115 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 G HVHV A + + +L + ++ +ALSA SP+ QG T + S R +++ +P G Sbjct: 116 GCHVHVAVADDAEGVAVLDRIGPWLAPLLALSANSPFWQGGATGYESFRSQVWARWPTAG 175 Query: 194 PMPWVSNWQQF-EALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 P + + + EA+ ++ T++D +++D R S + TVE+RV D L + AV Sbjct: 176 PTRVFGSPEAYHEAVAALVATGTVLDEAM-VYFDARLSARYPTVELRVADVCLDVDSAVL 234 Query: 253 MA----GLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 + GL++ A P + L + ++A GL+G + DP T Sbjct: 235 LGALARGLVETAARAAEAGEPPPDAPPE--LLRTAHWRAGHSGLDGDLLDPAT 285 >UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frankineae RepID=CAAL2_FRAAA Length = 383 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 8/225 (3%) Query: 115 RYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 RY+R FG ++ G HVHV S +A+ L L ++ +A++A SP+ QG Sbjct: 121 RYERMRGEFGLTAREQLTCGCHVHVAVHSRQEAVGALDRLRPWLSVLVAMTANSPFWQGA 180 Query: 175 DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFG 234 D+ +AS R ++ +P G + +++ + L T +++D+R S H+ Sbjct: 181 DSGYASYRTQVWQRWPTAGATGAFGSPAEYDRVVDLLIRTGAAMDDGMIYFDVRLSHHYP 240 Query: 235 TVEVRVMDTPLTLSHA-----VNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACR 289 T+E+RV D L++ + + A + A W E P + L + ++A R Sbjct: 241 TLELRVADVCLSVDDSVLLAALARALVATAARQWAAGE-PVPTVRPE--LLRAAGWRASR 297 Query: 290 YGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 +G+ G + D G+ P R +E + P G A+ AL Sbjct: 298 HGVSGELVDLERGELVPARALVDRFVEWVGPELSATGDGDAVAAL 342 >UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYE4_CATAD Length = 372 Score = 74.3 bits (181), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 88/333 (26%), Positives = 138/333 (41%), Gaps = 40/333 (12%) Query: 44 KITAGEVKHDITES---MLELATDV-CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 ++TA E++ D+ E+ +E A + R + AG S V Q + +LEI Sbjct: 65 RVTAAELRADLAETRGAAIEAAAGLDTRLVASGAGVLSRRPLPVTQ--SPRYLEIA---- 118 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 R+ L F ++ G H+H+G D A+ L L ++P Sbjct: 119 --------------RRFPDVLAEF-----ESEPSGCHIHLGTLDRDRAVLLGTRLRPWMP 159 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 +L+ SP+ G D AS R F +P GP P ++ A+ R + T++D Sbjct: 160 LLQSLAGNSPFAAGRDRGCASWRYFEFQHWPSAGPAPSLTGGGYERAVRRLMESGTVMDR 219 Query: 220 IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLL----TERPFKHQEK 275 K ++W RPS + T+E+RV D L+ V +A L++ A +L ++P ++ Sbjct: 220 -KMIYWFTRPSERWPTLEIRVADVNPDLNVPVLLALLVRGLAATILAALQADQPVPGTDE 278 Query: 276 DYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALH 335 L+ A R+GL DP +G E LLE P G L Sbjct: 279 HRLIEDHR--LAARFGLAAEGLDPVSGTLASAEERAASLLEFSRPGLEPGGDLETAALLL 336 Query: 336 RQV-VSGLNEAQLMRDFVADGG---SLIGLVKK 364 +V +G AQ DF G + GLVK+ Sbjct: 337 AEVRATGGGAAQQRADFQVRGSLSDVVDGLVKR 369 >UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Corynebacterium lipophiloflavum DSM 44291 RepID=C0XRA9_9CORY Length = 854 Score = 72.8 bits (177), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/294 (24%), Positives = 133/294 (45%), Gaps = 7/294 (2%) Query: 19 EMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSA 78 E+Q+V+ L+ + +L+ ++ A +++ SM+++A+ D+ + Sbjct: 6 ELQLVDKETRRLAPKADVLLSQLEGDAFAPSIQN----SMIQVASGSHGDVTSLRDELLQ 61 Query: 79 MQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVH 138 + A L I GT P + RY ++ L ++ + +H Sbjct: 62 GRARASSVAEPLGLAIAAAGTMPLAHRASLAITPRSRYMEMSADYALLAREQLICSAQIH 121 Query: 139 VGCASGDDAIYLLHGLSRFVPHFIALSAASPY-MQGTDTRFASSRPNIFSAFPDNGPMPW 197 V D A+ + G+SR +P +ALSA+SP+ ++G+DT +ASSR +P +GP Sbjct: 122 VEVRDRDQAVAVSPGVSRHLPLLLALSASSPFSVEGSDTGYASSRDLTGQRWPTSGPFAP 181 Query: 198 VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 VSN ++++ L L +I +++ + PS +E+RV D+ ++ +A L Sbjct: 182 VSNAKEYDELVDTLIKAGVIADEAMMYYSLAPSVSKPLLELRVCDSCPSVDAISTIAALF 241 Query: 258 QATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A L + + L++ ++A R GLEG + P T RP E Sbjct: 242 RAMVVREAALVDASTPTPPLNPTLHRSMMWRASRSGLEGSLICPETYTPRPAAE 295 >UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYG9_CATAD Length = 373 Score = 67.8 bits (164), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 104/234 (44%), Gaps = 9/234 (3%) Query: 110 VCDNERYQRTLENFGYLIQQ--ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAA 167 + + ERY+ E + + G HVHVG D+A+ L L ++P L+ Sbjct: 108 ITEGERYEEIAERYSAATTDIDSEASGCHVHVGDLECDEALALAGHLRPWLPVLQVLAVN 167 Query: 168 SPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDI 227 SP+ G+ R AS R A+P GP P ++ ++EA + L ++ + ++W Sbjct: 168 SPFAAGSFRRVASWRHYQQQAWPITGPTPMMTAL-EYEARAQELVDAGVLIDKRMIYWYA 226 Query: 228 RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLL----TERPFKHQEKDYLLYKFN 283 RPS H T+E+RV D + + +A L +A A LL + P E+ L + + Sbjct: 227 RPSEHQPTLEIRVADVCADVDITLLVAVLTRALAMVLLADVRADTPAPRTEE--LEVREH 284 Query: 284 RFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQ 337 A G G+ T P +G PL+ L+ P+ + + + L R+ Sbjct: 285 HRGAATLGPAGLWTHPLSGVSMPLSAGVEALVAHARPALEMLDETRLVAQLLRR 338 >UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanococcus vannielii SB RepID=A6US46_METVS Length = 367 Score = 44.7 bits (104), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 56/124 (45%), Gaps = 18/124 (14%) Query: 73 AGQFSAMQKVVLQAATDHH------LEICGGGTHP--------FQKWQRQEVCDNERYQR 118 +G ++K++ D H + G G HP F +EV D Sbjct: 60 SGSIKDLEKMLYDGMKDFHSRTNNCYNLMGLGMHPLLDLNGTAFWDHDEREVFDTYDRVF 119 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 L+ G+L Q+ V+V +S DD + + + +P+ +AL+A+SP ++G T++ Sbjct: 120 NLKQHGWLNIQSI----QVNVSYSSEDDMVLKHNKIRTMIPYLVALTASSPMVEGKLTKY 175 Query: 179 ASSR 182 A +R Sbjct: 176 ADNR 179 >UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFC0_9BACT Length = 417 Score = 42.4 bits (98), Expect = 0.027, Method: Compositional matrix adjust. Identities = 62/283 (21%), Positives = 113/283 (39%), Gaps = 47/283 (16%) Query: 14 LGIELEMQVVNPPGYDLSQDS-SMLIDAVKNKITAGEVKHDITESMLELATDVCR----- 67 GIELE +V+ + S+L+D +N T E+ + ELAT V Sbjct: 12 FGIELEYMIVDRDTLRPRPIAESILLD--ENGETTQEISLGSIDVSNELATHVLEFKTAG 69 Query: 68 ---DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ-------KWQRQEVCDNERYQ 117 D+ Q F+A + H+ + G HPF W + + + Y Sbjct: 70 PTADLEQLERDFAAAITEMNDRLAVHNAMLAPTGIHPFMDPAIESTTWSKGDRTIYDAYD 129 Query: 118 RTL--ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD 175 R + G+ Q+ H+++ A+ ++ L + +P+ ALSA+SP+++G Sbjct: 130 RIFGCSSHGWFNLQSC----HINLPFANEEEFARLHTAIILILPYLPALSASSPFIEGEY 185 Query: 176 TRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFG- 234 F +R +++ + +P ++ EA+F Y + I ++ + I+P G Sbjct: 186 RGFLDTRLDVYKN--NQAKVPEIAGDIVPEAIFTYADYQSQI--LEKTYAAIKPYDPDGI 241 Query: 235 ------------------TVEVRVMDTPLTLSHAVNMAGLIQA 259 +E+RV+DT + +A LI A Sbjct: 242 LQYEWLNSRGAIARFDRNAIEIRVLDTQENPKQDIGIASLIIA 284 >UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74515_SYNY3 Length = 389 Score = 42.0 bits (97), Expect = 0.037, Method: Compositional matrix adjust. Identities = 37/147 (25%), Positives = 70/147 (47%), Gaps = 13/147 (8%) Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 Q H+++G ++ I + P ++ALSA+SP++ G T + SSR +F Sbjct: 114 QVVTASIHINIGIPDVEELIRACRLVRMEAPLYLALSASSPFLNGQVTGYHSSRWQMFPK 173 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPS----PH-FGTVEVRVMD- 242 P P+ + S+ + L+ TM +++ L +RP+ PH +E+R+ D Sbjct: 174 TPQEVPL-FTSHGHFVQWTEEQLTLGTM-QNVRHLWSAVRPNGDNRPHNLNRLELRICDL 231 Query: 243 --TPLTLSHAVNMAGLIQATAHWLLTE 267 PL+L + + L++A +L + Sbjct: 232 VTNPLSL---LAIVALLEARLQQMLAD 255 >UniRef50_B6KJV5 Gamma-glutamylcysteine synthetase, putative n=3 Tax=Toxoplasma gondii RepID=B6KJV5_TOXGO Length = 1062 Score = 42.0 bits (97), Expect = 0.039, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 47/87 (54%), Gaps = 13/87 (14%) Query: 103 QKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHV-----GCASGDDAIYLLHGLSRF 157 Q+++RQ + + +TL + + VFG +H GC S DA YL L Sbjct: 350 QEYRRQLMMEG----KTLHDGRSIYMDHMVFGMGMHCAQATFGCPSLSDARYLYDQLGVL 405 Query: 158 VPHFIALSAASPYMQG----TDTRFAS 180 P +++L+AA+P+++G TDTR+A+ Sbjct: 406 APLWLSLTAATPFLRGLVAATDTRWAT 432 >UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD82_9ACTO Length = 122 Score = 41.6 bits (96), Expect = 0.053, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 4/111 (3%) Query: 9 SEP-FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKH-DITESMLELATDVC 66 +EP T+G+E E +V+P L+ ++++ A+ AGE H +I + LE +T VC Sbjct: 9 TEPGVTVGVEEEFHLVDPDTLVLTPGTTVVAAALAGD--AGEHVHPEIVSTQLETSTGVC 66 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 + + + SA + AA L + THPF W+ Q + RY+ Sbjct: 67 ATLPELRTELSATRAEAAAAAARDGLALLAASTHPFGTWREQRLTAAPRYR 117 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=B... 465 e-129 UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya... 453 e-126 UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synecho... 441 e-122 UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actino... 426 e-118 UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomy... 421 e-116 UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovi... 421 e-116 UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeoba... 420 e-116 UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bact... 419 e-116 UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 419 e-115 UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=... 411 e-113 UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cell... 410 e-113 UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Le... 409 e-113 UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromob... 409 e-112 UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubro... 408 e-112 UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinom... 406 e-112 UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechl... 406 e-112 UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actin... 405 e-111 UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterin... 405 e-111 UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 401 e-110 UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopir... 400 e-110 UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium... 399 e-109 UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinom... 398 e-109 UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia... 397 e-109 UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legione... 397 e-109 UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Strepto... 395 e-108 UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Plancto... 395 e-108 UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomy... 394 e-108 UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=No... 391 e-107 UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=A... 391 e-107 UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangi... 389 e-107 UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Sacch... 386 e-105 UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 384 e-105 UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromono... 383 e-105 UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=C... 383 e-105 UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=B... 382 e-104 UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 379 e-103 UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinom... 377 e-103 UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Coryneba... 376 e-103 UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia... 376 e-103 UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobact... 375 e-102 UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=... 374 e-102 UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 372 e-101 UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alph... 371 e-101 UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostoc... 369 e-101 UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales R... 368 e-100 UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environ... 368 e-100 UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salin... 367 e-100 UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubro... 367 e-100 UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromon... 367 e-100 UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 364 3e-99 UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Myco... 363 5e-99 UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineoco... 361 2e-98 UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp.... 361 2e-98 UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micr... 361 2e-98 UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rh... 360 6e-98 UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alpha... 357 5e-97 UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 356 9e-97 UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dass... 354 2e-96 UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellul... 353 5e-96 UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Maripro... 353 5e-96 UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xantho... 352 9e-96 UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces Re... 350 5e-95 UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromono... 350 6e-95 UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 346 7e-94 UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actin... 344 3e-93 UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 343 6e-93 UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=C... 339 1e-91 UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax... 339 1e-91 UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthr... 337 3e-91 UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 337 5e-91 UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 337 5e-91 UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=P... 336 1e-90 UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actin... 335 2e-90 UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax... 332 1e-89 UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseud... 331 4e-89 UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp... 329 2e-88 UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseud... 328 2e-88 UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Haloba... 325 2e-87 UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Strepto... 322 1e-86 UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=C... 321 2e-86 UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyc... 321 4e-86 UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubro... 320 5e-86 UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocar... 320 5e-86 UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphapr... 319 1e-85 UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Coryneb... 319 2e-85 UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocu... 317 4e-85 UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobact... 312 1e-83 UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frank... 311 3e-83 UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenuli... 307 3e-82 UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 304 3e-81 UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=C... 300 5e-80 UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenuli... 288 2e-76 UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudo... 286 9e-76 UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylob... 283 7e-75 UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseu... 277 4e-73 UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 250 6e-65 Sequences not found previously or not previously below threshold: UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74... 132 2e-29 UniRef50_Q31KY6 Glutamate--cysteine ligase, putative n=24 Tax=ce... 131 5e-29 UniRef50_B0KFE7 Methyltransferase small n=1 Tax=Pseudomonas puti... 119 1e-25 UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verru... 107 4e-22 UniRef50_B7K137 Glutamate/cysteine ligase n=9 Tax=Cyanobacteria ... 105 3e-21 UniRef50_Q39ZU6 Gamma-glutamylcysteine synthetase n=1 Tax=Peloba... 104 6e-21 UniRef50_Q2JXJ9 Glutamate-cysteine ligase, family 2 n=7 Tax=Bact... 100 1e-19 UniRef50_Q2BQQ6 Putative uncharacterized protein n=1 Tax=Neptuni... 100 2e-19 UniRef50_A0YFA7 Putative uncharacterized protein n=2 Tax=unclass... 97 1e-18 UniRef50_A2BYV9 Uncharacterized conserved protein n=7 Tax=Prochl... 96 1e-18 UniRef50_D2L0B8 Glutamate--cysteine ligase GCS2 n=2 Tax=Desulfov... 95 4e-18 UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilu... 95 4e-18 UniRef50_A3ZWT8 Putative uncharacterized protein n=1 Tax=Blastop... 93 2e-17 UniRef50_B9ZKM7 Putative uncharacterized protein n=1 Tax=Thioalk... 91 4e-17 UniRef50_B9TDX9 Putative uncharacterized protein (Fragment) n=1 ... 90 1e-16 UniRef50_Q1DCU0 Glutamate-cysteine ligase, family 2 n=2 Tax=Myxo... 89 2e-16 UniRef50_B7AQN9 Putative uncharacterized protein n=1 Tax=Bactero... 89 2e-16 UniRef50_B4VPR5 Glutamate-cysteine ligase family 2 n=1 Tax=Micro... 89 3e-16 UniRef50_C8QVM0 Glutamate--cysteine ligase GCS2 n=1 Tax=Desulfur... 87 8e-16 UniRef50_B8KSF5 Glutamate-cysteine ligase, family 2 n=2 Tax=uncl... 86 1e-15 UniRef50_Q092K6 Glutamate--cysteine ligase n=2 Tax=Cystobacterin... 85 3e-15 UniRef50_D1REB2 Carboxylate-amine ligase-like protein n=1 Tax=Le... 84 6e-15 UniRef50_A9TJF8 Predicted protein n=1 Tax=Physcomitrella patens ... 84 6e-15 UniRef50_Q4FMS2 Glutamate-cysteine ligase family 2(GCS2) n=2 Tax... 84 1e-14 UniRef50_Q5ZYJ4 AF2307 n=4 Tax=Legionella pneumophila RepID=Q5ZY... 84 1e-14 UniRef50_D1R9R1 Putative uncharacterized protein n=1 Tax=Parachl... 83 2e-14 UniRef50_D1ACB6 Glutamate/cysteine ligase family protein n=2 Tax... 83 2e-14 UniRef50_D0LKS0 Glutamate--cysteine ligase n=1 Tax=Haliangium oc... 83 2e-14 UniRef50_C7NPM2 Glutamate--cysteine ligase GCS2 n=4 Tax=Halobact... 82 4e-14 UniRef50_C9RNX1 Glutamate--cysteine ligase GCS2 n=1 Tax=Fibrobac... 82 4e-14 UniRef50_D2B0V7 Glutamate/cysteine ligase n=1 Tax=Streptosporang... 81 5e-14 UniRef50_UPI0001AEDC74 hypothetical protein SalbJ_18393 n=1 Tax=... 80 1e-13 UniRef50_O27977 Uncharacterized protein AF_2307 n=2 Tax=Archaeog... 80 2e-13 UniRef50_Q8TY80 Predicted metal-dependent hydrolase of the TIM-b... 79 2e-13 UniRef50_D2RRB5 Glutamate--cysteine ligase GCS2 n=2 Tax=Haloterr... 79 3e-13 UniRef50_Q2RLA4 Putative uncharacterized protein n=1 Tax=Moorell... 78 4e-13 UniRef50_D0MH09 CBS domain containing protein n=1 Tax=Rhodotherm... 78 5e-13 UniRef50_D2AYM1 Glutamate-cysteine ligase, family 2 n=2 Tax=Bact... 78 7e-13 UniRef50_D1X937 Glutamate/cysteine ligase family protein n=11 Ta... 77 9e-13 UniRef50_B6BSN8 Glutamate-cysteine ligase family 2 protein n=2 T... 77 1e-12 UniRef50_D0WIV7 Putative glutamate--cysteine ligase n=1 Tax=Slac... 77 1e-12 UniRef50_Q2SQ10 Uncharacterized conserved protein n=2 Tax=Gammap... 76 1e-12 UniRef50_A1K6A6 Glutamate-cysteine ligase n=5 Tax=Proteobacteria... 76 3e-12 UniRef50_C0W6H8 Putative uncharacterized protein n=1 Tax=Actinom... 76 3e-12 UniRef50_C8NRE4 Family 2 glutamate-cysteine ligase n=11 Tax=Acti... 75 4e-12 UniRef50_Q9JMV4 Putative glutathione synthetase GshA (Fragment) ... 75 4e-12 UniRef50_A0M1L9 GCS2 glutamate--cysteine ligase n=3 Tax=Flavobac... 74 1e-11 UniRef50_D0LNP6 CBS domain containing membrane protein n=3 Tax=M... 74 1e-11 UniRef50_C4GD43 Glutamate--cysteine ligase n=1 Tax=Shuttleworthi... 73 1e-11 UniRef50_D2RUA3 Putative uncharacterized protein n=1 Tax=Haloter... 73 2e-11 UniRef50_A8M1F4 Glutamate--cysteine ligase GCS2 n=2 Tax=Salinisp... 73 2e-11 UniRef50_C7MXH6 Gamma-glutamylcysteine synthetase n=2 Tax=Actino... 72 3e-11 UniRef50_C6XGY1 Glutamate--cysteine ligase n=2 Tax=Rhizobiaceae ... 72 3e-11 UniRef50_C8XBM8 Glutamate/cysteine ligase family protein n=1 Tax... 72 4e-11 UniRef50_A7I8T0 Glutamate--cysteine ligase, GCS2 n=6 Tax=Euryarc... 72 4e-11 UniRef50_Q5FPI3 Glutamate--cysteine ligase n=1 Tax=Gluconobacter... 71 6e-11 UniRef50_P46309 Glutamate--cysteine ligase, chloroplastic n=133 ... 71 9e-11 UniRef50_A6GCK2 Glutamate--cysteine ligase n=1 Tax=Plesiocystis ... 70 1e-10 UniRef50_B2HGM5 Putative uncharacterized protein n=3 Tax=Mycobac... 70 1e-10 UniRef50_C8WKE9 Glutamate--cysteine ligase n=2 Tax=Coriobacteria... 70 1e-10 UniRef50_Q11LE8 Glutamate--cysteine ligase n=22 Tax=Alphaproteob... 70 2e-10 UniRef50_B1MFR8 Glutamate--cysteine ligase GshA n=1 Tax=Mycobact... 69 3e-10 UniRef50_D2RU12 Glutamate--cysteine ligase GCS2 n=1 Tax=Haloterr... 68 7e-10 UniRef50_C0N7Q3 Putative uncharacterized protein n=1 Tax=Methylo... 68 8e-10 UniRef50_D0I9T0 Putative uncharacterized protein n=1 Tax=Grimont... 67 9e-10 UniRef50_A4CI62 CBS domain pair protein n=2 Tax=Flavobacteriales... 67 1e-09 UniRef50_A4RZD5 Gamma-glutamate cysteine synthase n=2 Tax=Viridi... 67 1e-09 UniRef50_B5ZRA7 Glutamate/cysteine ligase n=8 Tax=Rhizobium RepI... 67 1e-09 UniRef50_B4V5Z6 Glutamate-cysteine ligase n=10 Tax=Streptomyces ... 66 2e-09 UniRef50_C7NI09 Putative uncharacterized protein n=1 Tax=Kytococ... 66 2e-09 UniRef50_B4S4M7 Putative uncharacterized protein n=7 Tax=Chlorob... 66 2e-09 UniRef50_UPI00016C5767 glutamate--cysteine ligase n=1 Tax=Gemmat... 66 3e-09 UniRef50_B9ZBA6 Glutamate--cysteine ligase GCS2 n=1 Tax=Natrialb... 66 3e-09 UniRef50_A7HH96 Glutamate--cysteine ligase n=5 Tax=Cystobacterin... 65 4e-09 UniRef50_C1B0M2 Putative uncharacterized protein n=2 Tax=Rhodoco... 65 5e-09 UniRef50_C7ML88 Gamma-glutamylcysteine synthetase n=1 Tax=Crypto... 64 7e-09 UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanoc... 63 1e-08 UniRef50_C0EWU2 Putative uncharacterized protein n=1 Tax=Eubacte... 63 1e-08 UniRef50_UPI0001C36E32 Glutathione synthase n=1 Tax=Ruminococcus... 63 2e-08 UniRef50_Q6Z3A3 Glutamate--cysteine ligase B, chloroplastic n=81... 63 2e-08 UniRef50_A1WVT1 Glutamate--cysteine ligase, GCS2 n=2 Tax=Ectothi... 63 2e-08 UniRef50_C6MEH3 Putative uncharacterized protein n=1 Tax=Nitroso... 63 2e-08 UniRef50_A9GBM5 Glutamate--cysteine ligase n=1 Tax=Sorangium cel... 62 4e-08 UniRef50_A4T5Z6 Glutamate--cysteine ligase, GCS2 n=28 Tax=Actino... 61 5e-08 UniRef50_C4DKI0 Putative uncharacterized protein n=1 Tax=Stackeb... 61 5e-08 UniRef50_B9LUZ8 Putative uncharacterized protein n=8 Tax=Halobac... 61 5e-08 UniRef50_D0RQE4 Glutamate--cysteine ligase, (Gamma-glutamylcyste... 61 7e-08 UniRef50_Q2S261 CBS domain pair protein n=1 Tax=Salinibacter rub... 61 9e-08 UniRef50_A4FGC2 Glutamate-cysteine ligase n=3 Tax=Actinomycetale... 61 9e-08 UniRef50_D1PL70 Putative glutamate--cysteine ligase n=1 Tax=Subd... 60 2e-07 UniRef50_B1KDI6 CBS domain containing protein n=1 Tax=Shewanella... 59 2e-07 UniRef50_B4WP90 Putative uncharacterized protein n=3 Tax=Cyanoba... 59 2e-07 UniRef50_D2RSK6 Putative uncharacterized protein n=1 Tax=Haloter... 59 2e-07 UniRef50_D0L3Q4 Glutamate--cysteine ligase, GCS2 n=78 Tax=Actino... 59 3e-07 UniRef50_D1VG95 Glutamate/cysteine ligase family protein n=1 Tax... 58 6e-07 UniRef50_C7RFC6 Glutamate--cysteine ligase n=3 Tax=Anaerococcus ... 58 6e-07 UniRef50_A6TWY9 Glutamate--cysteine ligase n=2 Tax=Alkaliphilus ... 58 7e-07 UniRef50_Q0RAS7 Glutamate--cysteine ligase GSHA (Gamma-glutamylc... 56 3e-06 UniRef50_C1DH93 Glutamate-cysteine ligase-like protein n=1 Tax=A... 56 3e-06 UniRef50_A1ZDC2 CBS domain pair protein n=1 Tax=Microscilla mari... 54 6e-06 UniRef50_Q6ANW2 Glutathione synthetase n=1 Tax=Desulfotalea psyc... 54 8e-06 UniRef50_A1A2R1 Possible glutamate--cysteine ligase n=18 Tax=Bif... 54 1e-05 UniRef50_B0S3P4 Glutamate-cysteine ligase n=2 Tax=Finegoldia mag... 53 2e-05 UniRef50_UPI000180C776 PREDICTED: similar to Glutamate-cysteine ... 53 3e-05 UniRef50_C3JX20 Glutamate--cysteine ligase family protein n=5 Ta... 52 3e-05 UniRef50_C4RDQ5 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromono... 51 5e-05 UniRef50_D2MHE8 Putative uncharacterized protein n=1 Tax=Candida... 51 7e-05 UniRef50_B2A6L2 Glutamate--cysteine ligase n=1 Tax=Natranaerobiu... 51 7e-05 UniRef50_Q7W897 Putative uncharacterized protein n=4 Tax=Bordete... 51 9e-05 UniRef50_C7QH01 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenuli... 51 9e-05 UniRef50_C9NAH4 Putative uncharacterized protein n=1 Tax=Strepto... 49 2e-04 UniRef50_Q8YYX1 All0721 protein n=4 Tax=Nostocaceae RepID=Q8YYX1... 49 2e-04 UniRef50_D2RSM6 Putative uncharacterized protein n=1 Tax=Haloter... 49 3e-04 UniRef50_Q1WVP8 Glutamate--cysteine ligase n=12 Tax=Lactobacillu... 47 0.001 UniRef50_Q03Q55 Glutamate--cysteine ligase n=1 Tax=Lactobacillus... 47 0.001 UniRef50_D1N7M9 Glutathione synthase n=1 Tax=Victivallis vadensi... 46 0.002 UniRef50_Q8XK30 Glutathione synthetase n=11 Tax=Bacteria RepID=G... 46 0.002 UniRef50_Q127I4 Glutamate--cysteine ligase n=18 Tax=cellular org... 46 0.002 UniRef50_C2C3Y2 Bifunctional glutamate--cysteine ligase/glutathi... 46 0.002 UniRef50_B2SNT5 Glutamate--cysteine ligase n=3 Tax=Xanthomonas o... 45 0.004 UniRef50_D1VQH9 Glutamate/cysteine ligase family protein n=1 Tax... 44 0.006 UniRef50_B2GBB9 Glutamate--cysteine ligase n=8 Tax=Lactobacillus... 44 0.007 UniRef50_Q97IV1 Glutamate--cysteine ligase n=2 Tax=Clostridium R... 44 0.007 UniRef50_Q18FX4 Putative uncharacterized protein n=2 Tax=Halobac... 44 0.008 UniRef50_Q65RX0 Glutathione synthetase n=83 Tax=Bacteria RepID=G... 43 0.018 UniRef50_C2ZI28 Glutathione synthetase n=10 Tax=Bacilli RepID=C2... 43 0.021 UniRef50_B1MW57 Glutamate--cysteine ligase n=3 Tax=Leuconostoc R... 43 0.023 UniRef50_UPI0000382CE6 COG3572: Gamma-glutamylcysteine synthetas... 43 0.027 UniRef50_A7E7E9 Predicted protein n=1 Tax=Sclerotinia sclerotior... 41 0.057 >UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=Bacteria RepID=CAAL_ENT38 Length = 373 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 286/370 (77%), Positives = 329/370 (88%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 MPLPDFH S+PFTLGIELE+QVVNPPGYDLSQDSS LI AVKN I AGEVKHDITESMLE Sbjct: 1 MPLPDFHSSDPFTLGIELELQVVNPPGYDLSQDSSALIAAVKNDIKAGEVKHDITESMLE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +AT VC++I+QAA QFSAMQ+ +L+AA D H++I GGGTHPFQKWQRQEVCD+ERY L Sbjct: 61 IATGVCQNIDQAAAQFSAMQQAILRAAGDQHIQIAGGGTHPFQKWQRQEVCDDERYNHNL 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E FGYLI QATVFGQHVHVGC +GDDAIYLLHGLSRFVPHFIALSA+SPYMQG+DT+FAS Sbjct: 121 ELFGYLILQATVFGQHVHVGCRNGDDAIYLLHGLSRFVPHFIALSASSPYMQGSDTKFAS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR NIFS FPDNG MPWVSNWQ FE LFR LSYT+MID+IKD+HWDIRPSPHFGTVEVRV Sbjct: 181 SRLNIFSGFPDNGKMPWVSNWQGFEGLFRRLSYTSMIDTIKDVHWDIRPSPHFGTVEVRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 MDTPLTL+HA+N+AGLIQATAHWLLTERP+KHQE+DYLLYKFNRFQACRYGL+G++TD + Sbjct: 241 MDTPLTLAHAINIAGLIQATAHWLLTERPYKHQEQDYLLYKFNRFQACRYGLDGLLTDVN 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG+++ + ED LL+++APSA K+G +SAI + + G +EAQ MRDF+ADGGSLI Sbjct: 301 TGEQKTIAEDMKWLLDRVAPSAEKLGGASAIAEIALMLKQGKSEAQRMRDFIADGGSLIS 360 Query: 361 LVKKHCEIWA 370 LV+KHCE+WA Sbjct: 361 LVQKHCELWA 370 >UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YLQ7_9CYAN Length = 371 Score = 453 bits (1165), Expect = e-126, Method: Composition-based stats. Identities = 101/363 (27%), Positives = 176/363 (48%), Gaps = 2/363 (0%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 E TLG+E E Q+++P LS +I + V+ ++ +S +E+AT VC+ + Sbjct: 5 EGLTLGVEEEYQIIDPKTRQLSGRGEKIISFAEENYGKEIVQPEMHKSQIEIATSVCKSL 64 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + + S +++V++AA + I THPF W++QE N RYQ+ + + ++++ Sbjct: 65 AEVRSELSEARRIVIEAAQRDNKAIAAAATHPFSHWKQQETTANFRYQKLEQEYQQILRE 124 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 FG HVHVG + AI +++ ++ +ALSA SP+ G T + S R ++S F Sbjct: 125 LVTFGCHVHVGIEDKEVAIAVINRARMWLSVLLALSANSPFWLGKKTGYISYRTELWSPF 184 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G P +++ ++ L +I ++W+IR S H+ T+E RV D LT+ Sbjct: 185 PLFGSPPVFEDYKAYQNFVEQLIKMEVIQDTTTIYWNIRISEHYPTIEFRVSDICLTVDE 244 Query: 250 AVNMAGLIQATAHWLLTERP--FKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV +AGL++ L E F L K + A RYGL+G + D +P Sbjct: 245 AVMIAGLVRGLVQTCLIEIENDFPLIFVHPELLKTADWYAARYGLQGKLIDVMQQRSKPA 304 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 + + L + P+ +G + +L +V+ N AQ + G+++ +V E Sbjct: 305 KDLVKQFLNYVRPALESLGDWEEVSSLVDKVLKHGNAAQRQLEIYQRQGNIVEVVDYLVE 364 Query: 368 IWA 370 Sbjct: 365 QTR 367 >UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WGF8_9SYNE Length = 377 Score = 441 bits (1134), Expect = e-122, Method: Composition-based stats. Identities = 103/363 (28%), Positives = 170/363 (46%), Gaps = 2/363 (0%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 FT+G+E E Q+V+P L+ S LI +N T E+ H++ +E+AT +C + Sbjct: 3 PDFTIGVEEEYQIVDPETRSLADCSKSLIKTNQNSNTEQEIVHELFRCEVEIATGICHTL 62 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + + V++AA D+ I GTHPF W+ QEV ERY E+ +I++ Sbjct: 63 DDVRRALVQARTAVIEAAQDNGAVIAAAGTHPFSPWEEQEVTPKERYYALQEDLQQIIKE 122 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + G HVHVG + A+ + + ++P ++L+A SP+ G DT + S R ++ Sbjct: 123 LIILGCHVHVGVEDREMAVQISNRARIWLPLLLSLTANSPFCDGKDTGYDSYRMALWCRL 182 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P GP P+ N+ ++ + L T + D ++WDIR S F T+E R+ D ++ Sbjct: 183 PTAGPPPFFENYADYQGFIQKLIDTDITDDPTKVYWDIRLSERFPTIEFRMSDVCASIEE 242 Query: 250 AVNMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV +AG+I+A A+ + + K +QA R+GL G + D T + P Sbjct: 243 AVMLAGIIRALAYTCYQDVINGQPALPVRGEMLKAAMWQAARHGLSGELIDFATTESVPA 302 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 + I P G + ++ +++S N AQ R SL +V Sbjct: 303 KTLVQSFMRYIQPGLAHFGDEAIVKKEVDKILSEGNSAQRQRAVYEKTSSLESVVDDIVR 362 Query: 368 IWA 370 A Sbjct: 363 RSA 365 >UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actinomycetales RepID=CAAL_THEFY Length = 399 Score = 426 bits (1097), Expect = e-118, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 192/371 (51%), Gaps = 6/371 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE---VKHDITESMLEL 61 +F+ S+ TLG+E E+Q+V+ L QD+ L++ + A ++H++ +S +E+ Sbjct: 4 EFNPSKRATLGVEWELQLVDRDSGHLRQDAQKLLEELPELSGAESNPPLRHELMQSTIEV 63 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C +++ SA + QAA +E+ GTHP W+ QE ++RY +E Sbjct: 64 VTGICETVDEVKEDLSATVARLTQAADGRGIELACAGTHPIDDWRDQEFAPSQRYSELIE 123 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 +L ++ FG HVHVG D I +++ LSR++PHF+AL+A+SP+ G DT ASS Sbjct: 124 QMQWLARRILTFGVHVHVGVTDRDKVIPIVNALSRYLPHFLALTASSPFWSGHDTGLASS 183 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F A P GP P +++W FE L I SIK++ WDIRP P FGTVE+R+ Sbjct: 184 RSIVFGALPTAGPPPRLAHWGAFEEYMDTLLRAGTITSIKEVWWDIRPHPEFGTVEIRMF 243 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D T+ A L Q+ +R ++ + N+++A RYGL+ I Sbjct: 244 DGIPTVREVGMAAALSQSLVQLFEQQLDRGYRLPSPSSWVVTDNKWRATRYGLDARIIID 303 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 G PL +D LL ++ P A ++G + ++ + + G + + R + GG L Sbjct: 304 ERGSTVPLRDDLYELLHELRPIAERLGCAEDLDVVAEILHYGAS-YERQRAIIRQGGVLK 362 Query: 360 GLVKKHCEIWA 370 +V + + Sbjct: 363 DVVDALVKEFR 373 >UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomycetales RepID=D2SG64_9ACTO Length = 401 Score = 421 bits (1084), Expect = e-116, Method: Composition-based stats. Identities = 115/369 (31%), Positives = 192/369 (52%), Gaps = 5/369 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESM 58 M +P F SE +LG+E E+Q+V+ L+ + +++ ++ + KH++ +S Sbjct: 1 MQIP-FRSSERASLGVEWELQLVDVRTRQLTAGAVEILEELRPEGAEEHPKAKHELLQST 59 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E+ T VC + +A + V AA L + GTHP WQ Q++ ERY + Sbjct: 60 VEVITGVCTTVAEAKADLAGTVAEVRAAAERRGLGLMCAGTHPITDWQTQQISPKERYLQ 119 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E +L ++ +FG HVHVG + + AI +++ L+++VPHF+ALSA+SP+ G DT Sbjct: 120 LVEKMQWLARRLQIFGVHVHVGVRAPEKAIPIVNALTQYVPHFLALSASSPFWVGCDTGL 179 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G +S W +FE L T I+S++++ WDIRP P FGTVE+ Sbjct: 180 ASARSKVFEGMPTAGLPYQLSGWDRFEEYMETLISTHAIESVREVWWDIRPHPDFGTVEL 239 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 R+ D TL +A L Q T +R + + + N+++A RYGL+ I Sbjct: 240 RICDGLPTLDEIGAVAALSQCLVEQFDTQLDRGYTLPVPASWVLQENKWRAARYGLDADI 299 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 G RP+ + L+E++ P+A ++G + + +HR + G + + A G Sbjct: 300 VVDDKGTVRPVRQAITDLVEELEPTARRLGCEAELADVHRILAVGASYQRQRAVAAASDG 359 Query: 357 SLIGLVKKH 365 L +V Sbjct: 360 DLTAVVDSL 368 >UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovibrio bacteriovorus RepID=CAAL_BDEBA Length = 378 Score = 421 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 109/373 (29%), Positives = 201/373 (53%), Gaps = 6/373 (1%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P+P F S+ F+LG+E+E+Q+++P +L S +++ + + + +K ++ +SMLE+ Sbjct: 6 PIP-FGKSDLFSLGVEVELQIIHPETRNLFPISPDILE--EWSLQSPHLKPEVFQSMLEI 62 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C+++ + + + +L+ H + GTHPF KW + ++RY+ LE Sbjct: 63 DTPICKNVQEVEYELLLTSRELLRICKKHGARLASNGTHPFAKWHHRIFYPSDRYEYLLE 122 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 ++ ++ ++G HVH+G GD I +++ ++PH +A+SA+SP+ G DT ASS Sbjct: 123 RNQHIARRLMIYGLHVHLGMKDGDHCIAMMNEFLYYLPHMLAMSASSPFWTGHDTGLASS 182 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F A P G V NW QFE + + L+ + I S KD+ WDIRPSP++GT+E+R+ Sbjct: 183 RITVFEAHPAGGTPCRVENWAQFEDIVQKLTRSNSIGSFKDIWWDIRPSPNYGTLEIRIC 242 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D + + I A L E+ + Q D + + N+++A R+GL+ + Sbjct: 243 DGVPGIRKTTRLVAFIHLLAKHLQKRLEQGIRRQTPDDWMVRENKWRASRHGLDCEVLID 302 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 + G + L ED LL + A ++G + ++ L + ++ + ++ R GSL Sbjct: 303 NDGMTKNLREDIKDLLAAMKEDAAEMGYTEYLKQLVEEDLTHPS-YEIQRALFEKTGSLE 361 Query: 360 GLVKKHCEIWAGD 372 +V C+++ D Sbjct: 362 HVVDSLCDVFEKD 374 >UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeobacter violaceus RepID=CAAL_GLOVI Length = 372 Score = 420 bits (1080), Expect = e-116, Method: Composition-based stats. Identities = 104/368 (28%), Positives = 186/368 (50%), Gaps = 5/368 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG-EVKHDITESML 59 M +P F S TLG+E+E+Q+++P +L+ L+ + G VK ++ ++ + Sbjct: 1 MTIP-FQSSTAPTLGVEMELQIIDPATGNLTPRGPELVTFCEEHPEVGLVVKPELVQATI 59 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E+ T +C+D+ Q + ++ + + GTHPF +W+ + RY+ Sbjct: 60 EINTGICKDVAQVERDLTTQLTLLRSVCRERGVSFLSAGTHPFARWRERRYTQTPRYRAL 119 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 ++ + ++ ++G HVHVG GD AI +++ ++++ P +ALSA SP+ +G DT Sbjct: 120 VDKHVWTARRMQIYGLHVHVGMPDGDTAIQVINQITQYAPMLLALSANSPFWEGDDTGLD 179 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R +F G NW+ +E L L T I S +++ WDIRP FGT+EVR Sbjct: 180 SCRTKVFENLSSAGLPFRFENWEGYENLINVLLETGSIGSQREIWWDIRPHSDFGTIEVR 239 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 + D TL+ + + L+Q A + L E + + + + N+++ACR+GLEG + Sbjct: 240 ICDATRTLAEVLALTALVQCLAVYFRRLYENGEEIRLLHPGIIRENKWRACRWGLEGELI 299 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 DP T P + + + ++ A ++G S+ + A+ + SG N A R + S Sbjct: 300 DPLTLKGVPTRKLIEQTVGEMQSLAAELGCSAYLAAIPAILASG-NGATRQRRIYSQSRS 358 Query: 358 LIGLVKKH 365 L+ +V Sbjct: 359 LVAVVADL 366 >UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bacteria RepID=CAAL_CHLAA Length = 390 Score = 419 bits (1077), Expect = e-116, Method: Composition-based stats. Identities = 103/357 (28%), Positives = 169/357 (47%), Gaps = 4/357 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 FTLGIE E Q+V+P +L + +++ + I ++K ++ +S++E+ T CR I+ Sbjct: 12 AFTLGIEEEYQIVDPETRELRSYITQILEPGRT-ILREQIKPEMHQSIVEVGTRPCRTIS 70 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A + ++ + A H+L I GTHPF W +QE+ +ERY + Q Sbjct: 71 EARAEIVRLRSAIAGLAARHNLRIVAAGTHPFSSWMQQEITPDERYHMVVGEMQDAALQL 130 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 +FG H H+G + + AI L++ PH +ALS +SP+ G +T F S R IFS FP Sbjct: 131 LIFGMHCHIGMPNNEVAIELMNVARYICPHLLALSTSSPFWMGRNTGFKSYRSVIFSTFP 190 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G P + +FE + L T ID+ K + WD+RP P FGT+E RV D + Sbjct: 191 RTGIPPTFHSASEFERYVQLLVNTGCIDNGKKIWWDLRPHPFFGTLEFRVCDIATKVEEC 250 Query: 251 VNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A +QA + + E + L N+++A R+GL+G + D Sbjct: 251 LALAATMQALIVKFYTMFEENTTFRVYRRALINENKWRAQRWGLDGKLIDFGKRKEVEAK 310 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 ++E + +G+ +E L + V A A+ L +V Sbjct: 311 ALVHEIVELVDDVVDMLGSRREVEYLLKIV-ENGTSADRQLRVFAETNDLKAVVDNL 366 >UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0L2A3_GORB4 Length = 379 Score = 419 bits (1077), Expect = e-115, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 178/370 (48%), Gaps = 5/370 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--AGEVKHDITESM 58 +P F S +LG+E E + + DLS ++ L AV+ + AG+V ++ + Sbjct: 4 IPSIPFRGSPTPSLGVEWEFALTDKQSGDLSNSAAALFAAVEQRHPEHAGQVHKELLRNT 63 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +EL T VCR +A S VV A + +++ G GTHPF +W Q + + RY Sbjct: 64 VELVTGVCRTTAEALDDLSGTLGVVRGIADELGVDLYGAGTHPFAEWSTQLLTEGHRYAE 123 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E + +Q ++G HVHVG + D + +L L + PH +A+SA+SP G DT + Sbjct: 124 LIERTQWWGRQMLIWGVHVHVGISHRDKVLPILDALLNYYPHLLAISASSPMWAGQDTGY 183 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G + W +FE+ T +ID + ++ WDIRPSPH GT+EV Sbjct: 184 ASNRAMMFQQLPTAGLPFQFARWDEFESFVADQKTTGIIDHLNEIRWDIRPSPHLGTIEV 243 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 RV D L LI L E L + N+++A RYGL+ ++ Sbjct: 244 RVCDGMTNLRELSAAVALIHCLVVDLDRRLEAGETLPTMAPWLVQENKWRAARYGLDAIV 303 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 R +TED +L+++AP A + + + + SG + Q R A GG Sbjct: 304 ITDGNCAERLVTEDLAGVLDRLAPIARDLDCIDELAGVTSIIESGGS-YQRQRAVHAGGG 362 Query: 357 SLIGLVKKHC 366 ++ +V Sbjct: 363 TMRDVVASVV 372 >UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=C1A844_GEMAT Length = 404 Score = 411 bits (1057), Expect = e-113, Method: Composition-based stats. Identities = 102/366 (27%), Positives = 167/366 (45%), Gaps = 6/366 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + T+GIE E Q+++P DL+ L+ + ++ +VK ++ + +E+ T VC Sbjct: 2 RTPSLTVGIEEEYQIIDPVTRDLTPGFDALVTSEDAQL--ADVKAELHQCQVEIGTKVCS 59 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 I++ + ++ +V++AA H L I GTHPF W QE+ ERY L Sbjct: 60 SISELRTELVKLRGLVIKAAAQHGLTIASAGTHPFSNWMNQEMTPKERYLGVKAELQDLA 119 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + +FG HVHVG + I L+ +PH + LS +SP+ G +T S R +F Sbjct: 120 HRLLIFGTHVHVGIEDPEFRIDCLNASRYILPHILCLSTSSPFWFGRNTGLHSYRSIVFK 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 FP G ++ W + L L T I + WD+RP H+ T+E RV D + Sbjct: 180 NFPRTGVPRILNGWGDYADLVDTLQKTRSIPDGSKVWWDVRPHHHYPTLEFRVCDVNTRV 239 Query: 248 SHAVNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 AV +A ++QA W L + L + N+++A R+GL G + D + Sbjct: 240 DEAVCIAAILQAVVAKMWKLRRDNLTFRVYASDLIEENKWRAVRWGLGGKLIDFGKKEEL 299 Query: 306 PLTEDTLRLLEK-IAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P + L+E + ++G +E +R + G + AQ A G L +V + Sbjct: 300 PASVLIRELVEWFLDDVLDELGTRKEVEYAYRILEEG-SSAQRQLATYARTGDLRAVVDQ 358 Query: 365 HCEIWA 370 A Sbjct: 359 LIRETA 364 >UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cellular organisms RepID=CAAL_POLNA Length = 381 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 149/371 (40%), Positives = 230/371 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S +LG+ELEMQ+VN YDL+ + ++ + G V ++T SM+E Sbjct: 1 MSLEPFQKSSALSLGVELEMQLVNTHDYDLAPYAEDMLRLMSKIALPGAVVPEMTSSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 ++T +C + GQ + ++ ++++A ++ + GGGTHPFQ+W + + D R++ Sbjct: 61 VSTGICHSSAEVLGQLTQIRDALVKSADKLNIAVVGGGTHPFQQWHERRIYDKPRFRELS 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +GYL +Q T+FGQHVH+GC D A+ LH +SR++PHFIALSA+SPY+QG DT F S Sbjct: 121 ELYGYLSKQFTIFGQHVHIGCPDADTALLTLHRMSRYIPHFIALSASSPYVQGQDTAFDS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 +R N AFP +G P+ W +F F +++T ++ S+KD +WDIRP P FGT+E+RV Sbjct: 181 ARLNSVFAFPLSGRAPFALTWDEFTVYFNKMAHTGVVKSMKDFYWDIRPKPEFGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLT+ A +AG +Q+ W + ++PF E DYL+Y +NRFQACR+GL+ V DP Sbjct: 241 FDTPLTIERATALAGYVQSLGSWFMNDQPFMPTEDDYLVYTYNRFQACRFGLDAVYVDPA 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG PL E L + +I AH++ AS++I L V N+A+ +R+ + L Sbjct: 301 TGGHMPLREHILMTMAQIERHAHRLDASASIHLLRTSVERNDNDARWLRERQGEERLLAE 360 Query: 361 LVKKHCEIWAG 371 ++++ + + G Sbjct: 361 VIRQAADRFRG 371 >UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Legionella RepID=D1RC58_LEGLO Length = 402 Score = 409 bits (1052), Expect = e-113, Method: Composition-based stats. Identities = 107/366 (29%), Positives = 184/366 (50%), Gaps = 6/366 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F+ TLG+E+E+Q+++ Y+L + ++ A+ + ++K + S +E+ T+ Sbjct: 27 FNSGGVLTLGVEIELQLIDAETYNLCSRAEDILAAMSHL---EKIKPEFYLSTIEVNTNK 83 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C + + A + + + + G+HPF K+ E+ RY ++ + Sbjct: 84 CGSVQEVEDDLYATLFELQHVSKKLGILLSTTGSHPFSKYCDWEISPTARYLDLIDRNQW 143 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L ++ +V+G HVH+G +SG++ I + F+PH +ALS++SP+ QG DT AS RP Sbjct: 144 LTRRMSVYGLHVHLGMSSGEECIRFNNFFMYFLPHLLALSSSSPFWQGIDTGLASCRPTT 203 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 + A P G V +WQ FE L++ L I S+KDL WD+RPSP+FGT+E+RV D Sbjct: 204 YEALPTAGQPYHVRSWQDFEHLYKTLKSCGSIKSLKDLWWDLRPSPNFGTLEIRVCDGTA 263 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQE--KDYLLYKFNRFQACRYGLEGVITDPHTGD 303 TL+ + + LI A AHW + Y L + N+++A RYGL+ + G Sbjct: 264 TLAETLALVALIHALAHWFADNGSWLESVAYPPYWLSRENKWRAIRYGLDAELVMNTEGK 323 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 + + ED +EK+ P ++ + L + SG + + R S +VK Sbjct: 324 IKLMREDINEWIEKLKPYIEQLNYQTYFATLQSIMSSGTST-ERQRKVFTYNKSFKDVVK 382 Query: 364 KHCEIW 369 + + Sbjct: 383 HNVSEF 388 >UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromobacterium violaceum RepID=CAAL_CHRVO Length = 377 Score = 409 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 141/365 (38%), Positives = 220/365 (60%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 +F+ S+P TLG+ELE+ ++N Y+L++ S L+ + K ++K +IT+ M+E+ T Sbjct: 3 EFNQSQPLTLGVELELMILNRRDYNLTRGSDDLLLQINRKPHGYDIKPEITQGMIEIGTA 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V D+N + A++ +++ +A +L + GGG HPFQ W+ Q + ERY+ E +G Sbjct: 63 VHSDVNAMLDELLAIRTLLVDSAHKLNLGLAGGGAHPFQHWEDQRIYPKERYKLVSELYG 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 YL +Q TV+GQH+H+GC GD A+ L H L+R++PHFIALSA+SP+ QG DT F +SR Sbjct: 123 YLAKQFTVYGQHIHIGCPDGDAAVRLTHYLARYIPHFIALSASSPFYQGVDTSFQTSRLT 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +AFP +G MP V +W F A F + ++ S+KD +WDIRP P +GTVE+R+ DTP Sbjct: 183 SVNAFPLSGCMPVVDSWDAFNAYFERMEALGIVASMKDFYWDIRPKPEYGTVEIRICDTP 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 L++ V +A Q A E + YL Y +NRFQACR+G +GV+ D + + Sbjct: 243 LSVETPVLLAAYAQMLARRCFEESWNDICPEPYLTYSYNRFQACRFGFDGVMVDARSKSQ 302 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 L ED L L + P A +G+ + AL ++ + ++++ +R GSL +V++ Sbjct: 303 LGLQEDLLDTLRALEPHAEALGSQHQLAALRQRALKCHSDSRWLRQIFEQSGSLSEVVRR 362 Query: 365 HCEIW 369 E W Sbjct: 363 QSEHW 367 >UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL1_RUBXD Length = 376 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 102/370 (27%), Positives = 172/370 (46%), Gaps = 2/370 (0%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 MP+ + +TLG+E E+ +V+ +L ++ + + A V +++ +S+LE Sbjct: 1 MPVEFKLGNSGYTLGVEEELCIVDASTGELVPKIEEIMSRLPEDL-AEAVSYELFQSVLE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + T VCR + +A ++ V + GTHPF +++ Q+V ++ERY++ + Sbjct: 60 IKTPVCRTVGEAERVLRELRGRVGSWTAACGASLASAGTHPFSRYRDQKVTEHERYRQVI 119 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E ++ + +FGQHVHV ++AI + L+ P +ALSA SPY QG DT F S Sbjct: 120 EELRWVATREVIFGQHVHVAVPGPEEAIQAHNRLAEQAPLLLALSANSPYWQGMDTGFES 179 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR IF FP G P + FEA + +D WD+RP P GT+E+RV Sbjct: 180 SRVQIFETFPRAGMPPAFPEYAAFEAYVDLMVECGAMDDYTFCWWDVRPHPKLGTIELRV 239 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 +D+ L HAV + L Q L + + N+++A R GL+ D Sbjct: 240 LDSQTHLRHAVALTALTQCIVASSLEDEDAPKGPYHRDIALENKWRASRRGLDAAFFDVD 299 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P + +E++ P A ++G + + V G + ++ R+ G + Sbjct: 300 ERRNVPARDLARAAVERLRPHAQQLGCEEELLGVLEIV-EGGSGSRRQREIYEKSGDFLD 358 Query: 361 LVKKHCEIWA 370 +V E Sbjct: 359 VVAFLIEGTR 368 >UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinomycetales RepID=CAAL_CLAMS Length = 383 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 102/370 (27%), Positives = 182/370 (49%), Gaps = 3/370 (0%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF P +GIE E+ V+ +L+ + ++ + + V + + +E+ + Sbjct: 10 DFARQPPSRVGIEWELACVDRGSGELAGVAPQILRSFPHDDAHPHVTGEFLTNTVEVVSA 69 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCD-NERYQRTLENF 123 + A + + + V+ A +++ GTHPF W Q+V NERY L+ Sbjct: 70 PHSRVGHAVDDLARLIERVVDVADPLGIDLMCAGTHPFSAWPDQDVTPDNERYATLLDRT 129 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 + +Q ++G HVHVG G A+ +L+ L +P F ALSA+SP+ G +T +AS+R Sbjct: 130 RWWGRQMMIWGVHVHVGIEDGSKALPILNALLVHLPRFQALSASSPFWSGQETGYASNRA 189 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 +F P G P ++ W +E L +++ +ID +L WDIRP+P +GT+E RV D Sbjct: 190 LMFQQLPTAGLPPDLTTWADYERLIGDMTHVGVIDHHSELRWDIRPAPKWGTLETRVFDG 249 Query: 244 PLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 TL ++A L+Q H L +R + + N+++A RYG++ +I Sbjct: 250 VSTLGEIASLAALVQCLVHDLSAALDRGEELPRMQPWFVRENKWRAARYGMDAIIIQDAA 309 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 G+ + +DT L+E+++P+A +G + + + V G + + +R + G+L + Sbjct: 310 GEEALVGDDTRALVERLSPTADALGCEAELRGILDIVDRGASYQRQLRVAEENDGALAPV 369 Query: 362 VKKHCEIWAG 371 V E Sbjct: 370 VTHLVEELRS 379 >UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechloromonas aromatica RCB RepID=CAAL_DECAR Length = 384 Score = 406 bits (1043), Expect = e-112, Method: Composition-based stats. Identities = 145/369 (39%), Positives = 222/369 (60%) Query: 3 LPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 L DF S F+LG+ELE+Q+V+ +DL++ ++ L+ ++ GE+K +ITESM+E++ Sbjct: 6 LGDFKDSAAFSLGVELELQLVSKRDFDLTRGATDLLGSLDYDERFGEIKLEITESMIEIS 65 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 T ++ A S ++ + Q +++ ICGGGTHPF W + +C +R+ + Sbjct: 66 TQPQSTVDGIAADLSGLRDTLRQHCERNNIGICGGGTHPFHHWPERRICPGDRFNDLYQR 125 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 +GYL +Q TVFGQHVH+GC S D+AI+L +VP FIALSA+SP++ G D+ + S+R Sbjct: 126 YGYLAKQFTVFGQHVHIGCTSADEAIWLTQAFGVYVPAFIALSASSPFVDGVDSFYQSAR 185 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 N SAFP +G P + +WQ+F F L + SIKDL+WD+RP P FGTVE+RV D Sbjct: 186 LNAVSAFPLSGQCPPLGSWQEFTEHFAFLQACGIAQSIKDLYWDVRPKPEFGTVEIRVCD 245 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 TPLT+ A ++A L Q+ A WLL RP H K + ++N+FQACRYG E +I+DP Sbjct: 246 TPLTIEQATSLAALAQSLARWLLRTRPPLHTAKQAHVARYNKFQACRYGFEAMISDPVNL 305 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 + PL + LLE ++ A ++ + + L + V +A +R G+L +V Sbjct: 306 CQTPLKQTLADLLEAVSEDARELDCADWLSPLKQAVAENTGDAAWLRARENQHGNLNDVV 365 Query: 363 KKHCEIWAG 371 ++ + G Sbjct: 366 REASKRLMG 374 >UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actinomycetales RepID=CAAL_MYCUA Length = 392 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 97/363 (26%), Positives = 165/363 (45%), Gaps = 5/363 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF S T+G+E E +V+ DLS +++ +I + V ++ + +E+ + Sbjct: 27 DFARSPRPTVGVEWEFALVDAETRDLSNEATAVIAEIGEN---PRVHKELLRNTVEVVSG 83 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 VC +A + +E+ GTHPF +W Q++ D RY ++ Sbjct: 84 VCGSAGEAIEDLRTTLGPARRIVHARGMELFCEGTHPFAQWSTQKLTDAPRYAELIKRTQ 143 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 + +Q ++G HVHVG +S + + ++ L + PH +ALSA+SP+ G DT +AS+R Sbjct: 144 WWGRQMLIWGVHVHVGVSSANKVMPIISALLNYYPHLLALSASSPWWGGEDTGYASNRAM 203 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +F P G W +FE T +ID I ++ WDIRPSPH GT+E+R+ D Sbjct: 204 MFQQLPTAGLPFQFQTWSEFEGFVYDQKKTGIIDHINEIRWDIRPSPHLGTIELRICDGV 263 Query: 245 LTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 L + L+ L + + N+++A RYGL+ VI Sbjct: 264 SNLRELGALVALMHCLVVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDAES 323 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 + R +T+D +L ++ P A + + + A+ G + + R G L +V Sbjct: 324 NERLVTDDLDDVLTRLEPVARSLSCADELAAVAEIPRVGASYQRQRRVAEEHDGDLRAVV 383 Query: 363 KKH 365 Sbjct: 384 DAL 386 >UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterineae RepID=C2CS07_CORST Length = 381 Score = 405 bits (1041), Expect = e-111, Method: Composition-based stats. Identities = 92/368 (25%), Positives = 172/368 (46%), Gaps = 3/368 (0%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P F S TLG+E E+ +V+P +DL + LI+ V ++ + ++ +EL Sbjct: 4 PEESFARSAEPTLGVEWEVALVDPTTWDLVPRGAELIERVHAAAPEIHLEKEFLQNTVEL 63 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C + +A + V AA + +++ G HPF ++ V E Y + Sbjct: 64 VTGICHTVPEAVADLAHKLSHVRAAADEMGVKLWASGGHPFTDFRENPVSAKESYSEIIN 123 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y +Q ++G HVHVG D +++ L PH +A+SA SP +G DT +AS+ Sbjct: 124 RTQYWGKQMLLWGTHVHVGIRHEDRVWPIINALMTKYPHLLAISACSPAWEGLDTGYASN 183 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R ++ P G +W+++++ R + + +I+ +H+DIRP+ +GTVEVR+ Sbjct: 184 RTMLYQQLPTAGMPYQFQSWEEWQSYMRDQAISGVINHTGSMHFDIRPASKWGTVEVRIS 243 Query: 242 DTPLTLSHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D L +A L + +R + N+++ RYG++ ++ Sbjct: 244 DASSNLRELSAVAALTHCLVVHYDRMIDRGEELPILQPWHVAENKWRGARYGMDALVVTS 303 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 D R + ++ L+E++ P A ++G + + +H + G + R + GS Sbjct: 304 RETDERWIKDELADLVEELTPLARELGCAEELALIHEIIDDGA-GYERQRALYEETGSWQ 362 Query: 360 GLVKKHCE 367 +V+ C+ Sbjct: 363 KVVEATCQ 370 >UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JMG1_RHOER Length = 382 Score = 401 bits (1030), Expect = e-110, Method: Composition-based stats. Identities = 88/370 (23%), Positives = 159/370 (42%), Gaps = 6/370 (1%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P PD TLG+E E + +P + ++ + A + ++ ++T +E Sbjct: 5 PTPDIFSVGTPTLGVEEEFLLCDPQTGRPTLRNAEV--AAAGRELGISLQLELTRCQVET 62 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 +T + I Q + V AA ++ GT PF E+ RYQR Sbjct: 63 STSIGSHIRDLRDQLCESRAVTADAAARVGCQLIAVGT-PFYDPPVDEITQTSRYQRMAG 121 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 FG + + + G H+HVG + ++ +++ L ++P +AL+A SP G DT +AS Sbjct: 122 QFGAIT-EGVMCGCHIHVGVEDRERSVQIINHLRPWLPTLLALTANSPISAGRDTGYASW 180 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F +P +GP P + +E + T +I ++WD+R S H TVE+R+ Sbjct: 181 RYVLFGRWPSSGPPPCFESVAHYEDAVAAMLETGVILDPHMVYWDVRMSDHLPTVEIRIS 240 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D P T+ + +A L+QA + D+ L + ++A R GL+G D Sbjct: 241 DVPATVEETMTLATLVQALVGTASAAITKGEAAPAVDHELLRAACWRAARDGLDGRSLDV 300 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 + + +L++ + P+ G + A +V S N A + R + + Sbjct: 301 ESVRLLTAHQAVRQLVDHVEPALTAFGEFEQVTASLDKVFSNGNGAIVQRRQLTRRSRVA 360 Query: 360 GLVKKHCEIW 369 ++ + Sbjct: 361 DVIDECARRT 370 >UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopirellula baltica RepID=CAAL_RHOBA Length = 372 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 85/361 (23%), Positives = 160/361 (44%), Gaps = 10/361 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKN----KITAGEVKHDITESMLELATDVCR 67 T+G+E E Q+V+P L + ++ ++ + E++H++ + +E+A+DVC Sbjct: 6 PTVGVEEEYQLVDPRSGALIPNCKEVMRTIRRNGGSEEAHSEIQHELHLNQIEMASDVCS 65 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + + + +++++ AA + E+ GT+P + +RYQ + + + Sbjct: 66 SLEEVRDALTQTRRMLIDAARSNETELASAGTNPLPIPTDDALTPKDRYQAMTDRYQQIA 125 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + +FG HVHV + I +++ R++P A++A SPY G DT +AS R +++ Sbjct: 126 RDLFIFGCHVHVAMEDRELGIQVMNRCRRWLPILQAITANSPYWDGVDTGYASYRRELWA 185 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP + +++ L I L+WDIR T+E R D + Sbjct: 186 QWPMAGPPAHFDSLADYQSCVDDLVACGAIKDESFLYWDIRLPTRVPTIEFRAADVMTRV 245 Query: 248 SHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 V G+I+A + E+ + + + A RYG+ + DP + + Sbjct: 246 EETVGYVGMIRAIVMLAISEEEQGKPIVPIRPSVLSYAIWHAARYGMNEQLVDPESREMI 305 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P +E RL+ I P+ G + +EA Q++ A R GG L +V Sbjct: 306 PASELLNRLMTAIDPALKATGEARPVEAFANQLIKSGTGADRQR----RGGELSSVVANV 361 Query: 366 C 366 Sbjct: 362 V 362 >UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium genitalium ATCC 33030 RepID=C8NYP5_9CORY Length = 395 Score = 399 bits (1025), Expect = e-109, Method: Composition-based stats. Identities = 94/372 (25%), Positives = 166/372 (44%), Gaps = 3/372 (0%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P DF+ SE +LG+E E+ V++P DL +I AV ++ ++ + ++ +EL Sbjct: 25 PFRDFNRSEGPSLGVEWEIGVIDPATRDLVARGPEVIQAVNDRWPDVHLEKEFLQNTVEL 84 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T VCR+ +A A + + + +L++ G HPF ++ Q V D YQ + Sbjct: 85 VTPVCRNTAEAIEYLRATKDKIQAVTDEKNLQLWASGGHPFSDFREQAVGDKPTYQEIVN 144 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y QQ ++G HVHVG + +++ + PH +A+SAASP +G DT +AS+ Sbjct: 145 RTQYWGQQMLLWGTHVHVGIRHEERVWPIINAIMTKYPHLLAVSAASPAWEGLDTGYASN 204 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R ++ P G NW ++ R + + + +H+D+RP+ +GT+EVR+ Sbjct: 205 RTMLYQQLPTAGMPYQFQNWSEWVQFMRDQTTSGVTSHTGSMHFDVRPAAKWGTIEVRIS 264 Query: 242 DTPLTLSHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D TL + L + + N+++ RYGLE + Sbjct: 265 DASPTLRELAAVVALTHCLVVHYDAMLDDGRDLPTLQPWHVAENKWRGARYGLEAEVITS 324 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 D R +T++ ++E++ P A ++G + + + G Q R G Sbjct: 325 RATDERLVTDELYDMVEELQPVAQRLGCVDELNLVPGIIEQGA-AYQRQRAIYERTGDWR 383 Query: 360 GLVKKHCEIWAG 371 +V G Sbjct: 384 DVVDATVAELRG 395 >UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinomycetales RepID=D2AQS1_STRRD Length = 837 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 94/363 (25%), Positives = 172/363 (47%), Gaps = 5/363 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P +G+E E VV+ L + +L+D + A H++ S++E + + Sbjct: 7 PIAVGVEEEFHVVDVDTRHLVPRAGVLLDQ----LPADRFTHELQRSVVEANSRPFIRLE 62 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A+++ V+QAA L I G+ P + ++ + RY++ L ++ L ++ Sbjct: 63 DLGHDLTALRRTVIQAADGLGLGIVAAGSVPLVDLEALKISPDPRYEQMLADYQLLTREQ 122 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 + G VH + D A+ + H L+ ++P +ALS++SPY G+DT +AS RP I+ +P Sbjct: 123 LICGTQVHAEVDNRDLAVAVAHRLAPWLPPLLALSSSSPYWLGSDTGYASYRPLIWQRWP 182 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP+ + +++ + L + +I +++DIRPS H TVE+R+ D +S Sbjct: 183 TAGPVAAFESAAEYDQVVGDLVRSGVITDPGMIYFDIRPSAHVPTVELRICDACPRVSDI 242 Query: 251 VNMAGLIQATA-HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 V +AGL +A L R + + + ++A R GLEG + DP G RP E Sbjct: 243 VLIAGLFRALVARELEAVRRGPDRSVRLEMVRAATWRAARSGLEGDLVDPVEGVPRPAAE 302 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIW 369 R+++ + P + G + +L +Q + + + R GG L +V Sbjct: 303 VIGRMVDGLRPQLEESGDRELVTSLAQQALGRGSSSARQRRAFVRGGRLADVVDLLVAET 362 Query: 370 AGD 372 + Sbjct: 363 RSE 365 >UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia mucilaginosa RepID=D2NRT8_9MICC Length = 394 Score = 397 bits (1021), Expect = e-109, Method: Composition-based stats. Identities = 101/367 (27%), Positives = 166/367 (45%), Gaps = 11/367 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA--------GEVKHDITE 56 DF S TLG+E E+ +++ +L+Q + ++ ++ + V + E Sbjct: 15 DFASSPQSTLGVEWEIALIDRESGELTQRAGEVLSILRERRPELLEPASDRAHVTGEFLE 74 Query: 57 SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY 116 + +E+ T +C + +A Q + ++ + D +E GTHPF W Q V ERY Sbjct: 75 NTIEVVTGICHTVAEACRQLQELTDIIREITDDLGIEFYPAGTHPFSHWADQPVVAKERY 134 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 QR +E Y + ++G HVHVG S D + L+ L+ + PH +ALS +SPY G DT Sbjct: 135 QRVVERAQYWGRHMVIYGVHVHVGVDSRDKVLPLIDALTNYGPHLLALSCSSPYWDGIDT 194 Query: 177 RFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTV 236 +AS R ++ P NG W+Q+ L T +I+ + WD+RP P +GT+ Sbjct: 195 GYASHRTQLYQQLPTNGLPFHFDTWEQYSEYLDSLVATDVINDPSEDRWDVRPVPRYGTI 254 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEG 294 E+R D +L + Q + E + + N+++ RYGL+ Sbjct: 255 EMRYCDGLASLPDVAAIVAFTQCLVEYFSRQVEAGESIEVLAPWHAQENKWRVARYGLDA 314 Query: 295 VITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD 354 I + ++R L ED LL K+ P A + + + R + G A R Sbjct: 315 KIVVSNAPEQRTLREDFELLLPKLEPVARDLDCEVELAQVRRILAEG-TGADRQRAVFEK 373 Query: 355 GGSLIGL 361 GSL + Sbjct: 374 TGSLREV 380 >UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legionella RepID=CAAL_LEGPH Length = 383 Score = 397 bits (1021), Expect = e-109, Method: Composition-based stats. Identities = 145/372 (38%), Positives = 230/372 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S+ ++G ELE Q+++ L S L+ A+K+ ++K +IT+SM+E Sbjct: 1 MRLLSFKKSKIVSIGTELEFQIIDCSSLSLVSRSKELMRALKDMRYRDQIKPEITQSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + + + + + + +QK++++ A + CGGGTHPFQ+W Q++ ++R+++ Sbjct: 61 INSSIHQSAKEMYDELLELQKILVETAASIDIAFCGGGTHPFQQWTMQKIFPSKRFKKKF 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 + YL ++ATVFGQH+H+GC +GDDAIYL H L+R+VPHFIA+SA+SP+ G +T + S Sbjct: 121 NQYRYLSKRATVFGQHIHIGCPTGDDAIYLTHALARYVPHFIAISASSPFYLGINTNYCS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR IF+AFP +G +P++ NWQ+F +R + +I+++KD +WDIRP P GT+E+RV Sbjct: 181 SRSTIFNAFPLSGVIPYLRNWQEFSDYYRKMYRWKIIENMKDFYWDIRPKPELGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLTL ++ + IQA A +LL E+ + Y +Y +NRFQA R+GLEG +T Sbjct: 241 CDTPLTLRKSILITAYIQALALYLLEEKSVQLSHDLYYVYNYNRFQASRHGLEGELTVTD 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P+ +D L ++KI + +G S IE L+ V++ N++ L+ GS Sbjct: 301 KDRPIPIMDDILETIKKIEQYINGLGNSEYIEELYSDVINKQNDSVLINKIYKQDGSFSK 360 Query: 361 LVKKHCEIWAGD 372 LV CE+W D Sbjct: 361 LVAAQCELWLSD 372 >UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Streptomyces RepID=CAAL2_STRAW Length = 366 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 92/356 (25%), Positives = 166/356 (46%), Gaps = 6/356 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESMLELATDVCRDI 69 +T+G+E E +++P + + A + AGE ++ +++E+ +E+AT VC + Sbjct: 4 YTVGVEEEYLLLDPATRLPMPAAEQVRAAAGLEPIAGEDEIQPELSEAQVEVATPVCTSL 63 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 ++ G ++ V+ +AA + + GT P ++ + +N RY+ L+ + Sbjct: 64 DEIGGHLVRLRHVLGRAAESNGCRLAACGTPPIKEESPPPLTNNPRYRAMRAQAPQLVAE 123 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG + + +L+ + ++P +A+SA SP+ G DT FAS R IF + Sbjct: 124 QLVCGTHVHVGVPDPEIGVAVLNRIRLWLPVLVAMSANSPFWAGHDTGFASWRTVIFGRW 183 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P +GP P ++ E + L +I L+W R S + TVEVR +D L Sbjct: 184 PVSGPPPHFADLADHEKRVQQLLTCGVIFDPGQLYWQARLSSRYPTVEVRCLDVQLRADD 243 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV AG+++A + + L + + A R+GL G + D + G RR Sbjct: 244 AVMFAGIVRALVATAINDAKAGVPVPSCPPELLQGANWHAARHGLSGSLID-YEGRRRSA 302 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 + +L++ I P+ S + +L +++ A R + GG L + Sbjct: 303 GDVLSQLMDHIGPALDAADDSREVASLVHRLLREGTPADRQRRALLRGG-LRAVTD 357 >UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Planctomycetaceae RepID=A3ZKZ3_9PLAN Length = 378 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 107/372 (28%), Positives = 183/372 (49%), Gaps = 4/372 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F ++ FT+GIELE+ +V+ LS L+DA ++ A +K ++ + LE Sbjct: 1 MSKLVFTSNDAFTVGIELELGLVDSQTMALSSSVQRLLDAAPAEL-ASRIKPELMQCCLE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + T++C I +A V D L + G THPF W Q+V NERY + Sbjct: 60 INTEICTTIEEAESDLRRKLLAVQGLTDDLGLRLWWGSTHPFSHWCDQKVTQNERYLNLV 119 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 + + ++ G HVHVG SGD A+ + + +++P +ALS +SPY +G DT AS Sbjct: 120 DLLQEMARRLVTNGLHVHVGVESGDKAVMICDRIMQYLPLLLALSTSSPYWEGRDTGLAS 179 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R I P G P + NW ++ L + T I++I+++ WD+RP +FGTVEVRV Sbjct: 180 HRSKIMEGLPTAGLPPLMRNWSEYVWLVNHMVDTGFINTIREIWWDVRPHHNFGTVEVRV 239 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKD--YLLYKFNRFQACRYGLEGVITD 298 D P L A+ ++ +IQ L E + D ++ + N+++ACR+G + + + Sbjct: 240 CDMPGNLEDAMTISAMIQCLVKQLSDEIDHGAYQHDCHPMMVRQNKWRACRFGSDAKLVN 299 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 +T ++ RL+E++ A ++G + + + + R + + G Sbjct: 300 SYTYQVESVSTVVARLVERLMAPAIELGCERYLLR-AQDIADRPTWSDRQRLILQETGDP 358 Query: 359 IGLVKKHCEIWA 370 +V++ E Sbjct: 359 TEIVRRMSEQSR 370 >UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomycetales RepID=C5BZX5_BEUC1 Length = 388 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 91/366 (24%), Positives = 171/366 (46%), Gaps = 4/366 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESMLELA 62 +F SE ++GIE E+ +V+ DL Q + ++DAV+ +K ++ + +E+ Sbjct: 8 EFAHSERSSVGIEWELALVDADSGDLRQVAQTVLDAVRPDGAEEHPLIKQELLLNTVEVV 67 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + V R + A + + +E+ G+HPF +W +Q+V + ERY ++ Sbjct: 68 SGVQRTVADAGRDLERAIDAIREVTDPLRVELMCAGSHPFARWTQQKVTNKERYATLIDR 127 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 + +Q ++G H HVG + + + PH +LSA+SP+ G DT +AS+R Sbjct: 128 TQWWGRQMLIYGVHTHVGIEDRSKVLPIARAMLTVAPHLQSLSASSPFWGGKDTGYASNR 187 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 +F P G + W + E + +T +ID + ++ WDIRPSP GT+EVRV D Sbjct: 188 ALMFQQLPTAGLPFAFTEWAELEQYVGDMLHTGVIDDVTEIRWDIRPSPRLGTLEVRVCD 247 Query: 243 TPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 TL + ++ + + + + N++++ RYG++ ++ Sbjct: 248 GTPTLGELLALSAFTHCLVEHFSSMLDAGEQLPAMPPWFVQENKWRSARYGMDAILILDA 307 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 GD R +T+ L+ + P A ++G S+ ++ + + G + + GG L Sbjct: 308 DGDERLVTDSVHDWLQVLEPVAERLGCSAELDDVRAILRDGASYQRQRAAAERAGGELDA 367 Query: 361 LVKKHC 366 +V Sbjct: 368 VVDLLV 373 >UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=Nocardiaceae RepID=CAAL3_RHOSR Length = 385 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 91/365 (24%), Positives = 153/365 (41%), Gaps = 6/365 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 E TLG+E E +V+P S ++ +I + ++ +++ +E AT + Sbjct: 11 RRDEIPTLGVEEEFVLVDPHTGRPSLSNTDVI--ASGRELGITLQPELSRCQIETATSIG 68 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 I Q + V AA ++ GT P + D R++R E FG L Sbjct: 69 THIRDLRDQLCESRAVTADAAARTGCQLLAVGT-PMYSPPHDSITDTPRHRRIAEQFGAL 127 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + G HVHVG + AI +++ L ++P +AL+A SP G DT +AS R +F Sbjct: 128 AT-GVMCGCHVHVGVPGREQAIQIINHLRPWLPTLLALTANSPIADGCDTGYASWRYILF 186 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P GP P+ + ++A + + I + + WD+R + H TVEVR+ D P T Sbjct: 187 GHWPSAGPPPYFDSAAHYDAALAKMLESGAILDNRMVFWDVRAADHPPTVEVRISDVPAT 246 Query: 247 LSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + + + L+ A ER D+ + ++A R GL G D T Sbjct: 247 VEETMTLTTLVHALVITAADAIERGTPAPTVDHEALRGACWRAARDGLSGHGFDLTTMGL 306 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P +LL + P ++G + V+ N A R +A G + ++ + Sbjct: 307 IPAPRLIYQLLTHVKPVLVELGECGQVTGSLAAVLEHGNGAIRQRRTLARHGRVADVIAE 366 Query: 365 HCEIW 369 Sbjct: 367 CARRT 371 >UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=Actinomycetales RepID=CAAL2_FRASC Length = 861 Score = 391 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 76/352 (21%), Positives = 153/352 (43%), Gaps = 6/352 (1%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E E +++ L + ++ ++ ++ +S++E + D+ + Sbjct: 9 VGVEEEFHILDLTTRQLVPRAEEVL----RRLDGDSFSPELLKSVVETNSQPTADLLELR 64 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 +++ + + + L GT P +V ++RY++ E++ + ++ + Sbjct: 65 TNLLDLRRRLAEVTGELGLGPAAAGTVPIVDMDLLDVSRDDRYEQMTEDYQIVAREQLIC 124 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 G VHV A D A+ ++ + ++P +ALSA+SP+ G D+ +AS R ++ +P G Sbjct: 125 GAQVHVDVADRDLAMAVVAWTAPWLPMLLALSASSPFWMGADSGYASMRTLVWQRWPTAG 184 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 +++ L L + +I +++D+RPS H TVE+R+ D + + + + Sbjct: 185 VAGSFRTAAEYDQLVADLIKSGVISDPGMVYFDVRPSAHLPTVELRICDACPDVDNVILI 244 Query: 254 AGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 AGL +A + E + L + ++A R GLEG + D P Sbjct: 245 AGLFRALVCQAIEEIEAGGQAPPPRAELLRAATWRAARSGLEGDLVDILGAGPIPAQAML 304 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 RLL ++ P + I+ L Q V + A R A G L + Sbjct: 305 RRLLTEVRPQLERFDDWELIDNLAEQAVGRGSSAHRQRRAFARRGLLTDVAD 356 >UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2AQR8_STRRD Length = 370 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 95/365 (26%), Positives = 158/365 (43%), Gaps = 5/365 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + T+G+E E + + + +++ G V+ ++ + +E + VCR Sbjct: 2 RASELTVGVEEEFFLADVATRHAVLRAETVLEGTAPVPGGGRVEPELARAQVESVSAVCR 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 DI + +++ V AA + + G P V D RY R E FG L+ Sbjct: 62 DIGSLREELLRLRRSVAAAAESNGCRLVASGVVPLGDPGPPPVSDRPRYHRIAERFGPLL 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 Q + HVHVG ++A+ +++ L ++P + LS+ SP+ +G DT +AS R +F+ Sbjct: 122 DQQSACACHVHVGVPDPEEAVQVVNHLRMWLPVLLVLSSNSPFWRGRDTGYASWRTPLFA 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P++S ++E + CL T I L W RPS H TVEVR+ D T+ Sbjct: 182 RWPTAGPPPYLSGRAEYEEIVECLRETGAILDGGMLFWYARPSRHVPTVEVRIADVMPTV 241 Query: 248 SHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDP---HTG 302 V A L++A +LT+ R L + ++A RYGL G D Sbjct: 242 DDTVLFAALVRALVATVLTDLRRGRAAPAAGDHLLRAACWRAARYGLRGDGVDVSGRVDE 301 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 P + +L+E ++P+ G A+ A R + A R +V Sbjct: 302 RLIPASGQIKQLMEYVSPALEASGEDGAVRAGLRALRLRGTGADRQRAAYRRRNRFEDVV 361 Query: 363 KKHCE 367 + Sbjct: 362 DLLAD 366 >UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=CAAL1_SACEN Length = 374 Score = 386 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 93/354 (26%), Positives = 166/354 (46%), Gaps = 4/354 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++P + + + D + + GEV ++ + +E AT VCR + + Sbjct: 4 LTLGVEEEFLLLDPGTLEPAAAA----DRFRAETDRGEVHRELAPAQIESATAVCRTLEE 59 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 S +++ + A + + G P V D+ RY+R E +G +I+ Sbjct: 60 LHHDLSGLRRALAADAAEQGYRLASVGVPPIGSAGPPPVTDSPRYRRMYETYGSIIEDQG 119 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + L ++P + L+ SP+ +G DT +AS R ++S +P Sbjct: 120 VCGCHVHVGALDLETALVAGNHLRPWLPALLLLTTNSPFFRGGDTGYASWRTTLWSRWPA 179 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P +++ + + + CL + + L+W RPS T+EVRV D T+ AV Sbjct: 180 AGPPPVLTSARHYHYVVDCLLASGAVLDSGMLYWYARPSHRVPTLEVRVADAAATVDEAV 239 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 +AGL++ L++RP + D + + + + +GLEG D TG P Sbjct: 240 LLAGLVRGLVGVALSDRPGPVRPVDDAVLRAACWCSAHHGLEGFSLDVGTGRLVPSWHLV 299 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 L+E + P + G A+ AL ++ + A+ R+ + +V+ Sbjct: 300 DDLVEHVRPVLERYGDLDAVRALLAKLRENGSAARRQREVFRRHRDIGEVVEHV 353 >UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6W8C0_ACTMD Length = 373 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 93/369 (25%), Positives = 165/369 (44%), Gaps = 4/369 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 +P+P T+G+E E +V+ +L ++ ++ +++ ++T+ +E Sbjct: 9 LPIPRSGSGTALTIGVEEEFLLVDEVTGELVPLGPQVLSGPPDR--GLDLQPEMTQYQVE 66 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 AT VCR ++ Q A + + + A H + G + D+ RY+R + Sbjct: 67 SATAVCRTASEVREQLLAARAALARRAAAHGARLVASGAPVLGGEHPPPLTDHPRYRRIM 126 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +G L+ T+ G HVHVG S + + + + L R++P +ALSA SP+ +G DT +AS Sbjct: 127 ERYGALVDGLTICGCHVHVGIPSPSEGLVISNHLRRWLPVLLALSANSPFHEGRDTGYAS 186 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R +++ +P GP PW + + + L + ++WD+R S + TVE+RV Sbjct: 187 WRHVVWNPWPSAGPPPWFDSVEDYRLATHLLRTSGAALDDGMVYWDVRLSANHPTVELRV 246 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D T+ AV +A L++A A L+ L + +QA R+G EG DP Sbjct: 247 CDVAATVEEAVVLAALVRAIAATALS--GEAAPRVSDRLLRVALWQAARHGPEGAAVDPL 304 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 +G P E+ LL + G + + +++ A R G Sbjct: 305 SGVPVPFAEEVGGLLRWCGAALDAAGDTELVVEGVARLLRDGGGAARQRKAYRRRGEFTD 364 Query: 361 LVKKHCEIW 369 +V+ Sbjct: 365 VVELLTTRT 373 >UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromonospora RepID=C4RQD7_9ACTO Length = 382 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 86/366 (23%), Positives = 163/366 (44%), Gaps = 4/366 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++ FT+G+E E +V+P ++++ V ++ G+V+ + S +E+ + Sbjct: 18 GGTDLFTVGVEEEFLLVDPHTGTAVPAVDLVMEQVPAEL-RGQVEREFQTSQIEIGSPPG 76 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 +++ +++ + AA + + GT V D R+ R +E F L Sbjct: 77 LELSSIRHSLGVLRRALADAAERAGVRVLAIGTG-PVDGPVPPVVDKPRFDRMIERFRLL 135 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + G HVHVG + + +L+ + ++P A++ SP+ G DT +AS R + Sbjct: 136 VPGPGNNGMHVHVGVPDPETGVRVLNHVRPWLPILHAVTTNSPFFAGEDTGYASWRSVEW 195 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P P P++ + + +E L R L + ++ L+W R S + TVE+R+ D + Sbjct: 196 ERWPSVAPTPYLESHEHYERLIRQLIASGVMLDEGMLYWYARLSAKYPTVEIRIGDVCPS 255 Query: 247 LSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + AV +A L++A +T+ D+ L ++A GLEG D G+ Sbjct: 256 VDDAVLVAALVRALVATAMTDIAEGRPPIRTDHHLLVAAHWRAAHDGLEGQCVDLTDGEL 315 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 RP E L+E++ P+ + G + + L + A R A GSL+ +V+ Sbjct: 316 RPGWERLDSLVERLGPALERHGDLAEVTDLLGGLRRHGTGAARQRAVFARTGSLVDVVRD 375 Query: 365 HCEIWA 370 Sbjct: 376 VARQTR 381 >UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C317D2 Length = 366 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 107/365 (29%), Positives = 183/365 (50%), Gaps = 7/365 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +T+GIE E+ +++ +L+ I+ + T+ +VK ++ ES+LE+AT Sbjct: 6 DGPNYTIGIEEELMILDAESLELANA----IEGMLEDSTSDQVKPELMESVLEIATSPQP 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D A + +++ V + A L I GTHPF W+ Q + RY+ + + ++ Sbjct: 62 DAAAAGEELRDLRRQVRETAASRGLAIGSAGTHPFAMWEEQRIVGRTRYRDLVSDLKFVA 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +Q +FGQHVHVG D AI++ +G+ +P +ALSA SP+ + T AS+R IF Sbjct: 122 RQEIIFGQHVHVGLDDADKAIHVANGMRIHLPVLLALSANSPFWRADATGLASTRTPIFR 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 AFP G P +W + A + + +I+ L +D+RP P+ GTVE+RVMD+ + Sbjct: 182 AFPRVGIPPTYDDWDDYAAKIGFMVESRVIEDYTYLWYDVRPHPNLGTVEIRVMDSQTRV 241 Query: 248 SHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 H + A LIQA L E + + + + N++ A R+GL+G + D + +R Sbjct: 242 EHTLAFAALIQAMVKELAEHFEAGKRLSKYPHQMIDENKWLAARHGLDGELVDLPSTERV 301 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 E RLL+++ A +G+++ +E + ++ N A R L +V + Sbjct: 302 RTRELAHRLLDRLRDHAQDLGSAAELEGI-EDLLERGNGAARQRVVYEANHDLREVVAEI 360 Query: 366 CEIWA 370 A Sbjct: 361 VAATA 365 >UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=Bacteria RepID=CAAL4_RHOSR Length = 793 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 85/367 (23%), Positives = 163/367 (44%), Gaps = 7/367 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 S+P +G+E E +++ L+ + L+ + + + ++ + ++E+ + V Sbjct: 3 ASDPRKVGVEEEFHLIDLKTRRLTTRAPELLARLPDDVYVD----ELQQCVVEVNSGVYA 58 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D++ +++++ AA D + + G+ P V +RY R L ++ L Sbjct: 59 DLDGLRSDLERHRRLLVDAAEDLGIGVAAAGSVPLALPAEMHVTGTQRYGRMLADYQVLA 118 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM-QGTDTRFASSRPNIF 186 ++ + G VHV D+A+ + H ++ +P +ALSA+SP+ G DT +AS+R ++ Sbjct: 119 REQLICGTQVHVDLPDRDEAVQVAHRVAPHMPVLLALSASSPFRSDGADTGYASARTLLW 178 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P GP VS+ ++ AL L + +I ++D+RPS T+E+RV D+ Sbjct: 179 LRWPSTGPAAPVSSAAEYGALIDDLVASGVISDPGMAYFDVRPSVKLPTLELRVCDSCPR 238 Query: 247 LSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 L + +A L +A + K E L + ++A R GLE + D Sbjct: 239 LDTVLLVAALFRALVEREVEGLRAGRKGVEVLPTLTRAALWRAARSGLEEELVDVTVPQA 298 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 RP +E + + P + G + L + + + A R + G L +V Sbjct: 299 RPASELVGDFVNSLRPQLEETGDWDRVVELSAEATAHGSSAARQRQALGRRGRLTDVVDL 358 Query: 365 HCEIWAG 371 AG Sbjct: 359 LLAETAG 365 >UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JVV2_RHOER Length = 392 Score = 379 bits (973), Expect = e-103, Method: Composition-based stats. Identities = 93/365 (25%), Positives = 165/365 (45%), Gaps = 6/365 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 H S T+G+E E +V+P + S D++ + + +++ +++ +E + VC Sbjct: 14 HESTTPTVGVEEEFILVDPTSWLPSTDNAAVAETAS--TLGLDLQLELSRCQVETNSPVC 71 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 I++ + M+++ +AA + + G P R E+ D+ RY+R E FG L Sbjct: 72 HGIDELRTHLTDMRRLAAKAAELNGCRLLAVGA-PLSGPSRFEISDSPRYRRMGERFGAL 130 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + ++ G H+HVG A A+ + + + ++P +ALSA S QG DT FAS R + Sbjct: 131 AAEQSICGCHIHVGVADQVQAVQVCNHVRIWLPALLALSANSRVHQGVDTDFASWRAIQW 190 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P+ F+ + ++ + +WDIRPS H TVE+RV D T Sbjct: 191 SRWPVAGPPPYFETTGDFDTAVAKMVDCGVMLDKRMAYWDIRPSCHLPTVEIRVCDVQPT 250 Query: 247 LSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 A +A L +A L +R + + + + + G+ G DP T R Sbjct: 251 AEDAALLATLGRALVATALRAIDRGIEAPNISLESLRLATWVSAKEGVLGASIDPITSQR 310 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 TE RLL + S + G +++E+ + N + + + L L+ + Sbjct: 311 ISATELLHRLLIHVRDSLDEGGEYASVESALQHKSVTGNGSDWQQRTLRQV-CLRELIAR 369 Query: 365 HCEIW 369 + Sbjct: 370 AVQRT 374 >UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinomycetales RepID=B8HF13_ARTCA Length = 409 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 87/366 (23%), Positives = 150/366 (40%), Gaps = 7/366 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLID---AVKNKITAGEVKHDITESMLELATDVCR 67 P T G+E E+ +V+P D + L+D + + + M+E+ T Sbjct: 33 PRTFGVEEELLLVDPGRGDAVPMAGALLDLYVRPLESSAGPVLTAEFQQEMIEVVTPPHS 92 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A + + QAA D + + GT P R+ +E +G Sbjct: 93 TLAGLQADIVAGRDIARQAAEDVGVRVAALGTSPL--PSDPHPVRLRRFAAMVEEYGLTA 150 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ G HVHV S ++A+ +L + ++P +ALSA SP+ G DT +AS R ++S Sbjct: 151 REQLTCGTHVHVSVESDEEAVGVLDRIRNWLPVLVALSANSPFWHGEDTGYASYRSQVWS 210 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP+ + + L + T + +++D R S H+ TVEVR+ D + Sbjct: 211 RWPSAGPLDILGTPDAYHQLVHDMVSTGVAMDEGMIYFDARLSRHYPTVEVRIADACMMP 270 Query: 248 SHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + V +AG+++ E L + ++A R+GL G + DP T Sbjct: 271 ENTVLLAGIVRGLVETAAREWKAGTGPAPVPTALLRLAGWKASRWGLRGELLDPVTSRPG 330 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P LL I + +G +E L Q++ A + + G L +V Sbjct: 331 PALGVVNSLLHHIHGALEDMGDLERVEELTDQLLHTGTGAVRQLEVLHRTGDLEDVVDDA 390 Query: 366 CEIWAG 371 G Sbjct: 391 ANCTVG 396 >UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Corynebacterium RepID=CAAL_CORU7 Length = 394 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 89/342 (26%), Positives = 168/342 (49%), Gaps = 4/342 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF SEP T+G+E E+ +++P DL + L+D + V + + +E+ T Sbjct: 2 DFPGSEP-TVGLEWEVALIDPETLDLVPRAGELLDLMDEVYPGHRVTREFMANTVEMVTT 60 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V +I A +L A + + GTHPF W QE+ D + YQ +E Sbjct: 61 VHGNIPAAVEDLREQLLQLLDCADRIGVLLFSAGTHPFTNWGDQEMSDKKSYQEIIERTQ 120 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 Y +Q ++G HVHVG S + +++ + PH +A+SA+SP +G DT +AS+R Sbjct: 121 YWGRQMIIWGIHVHVGVGSKEKVWPIINAVMTHYPHVLAMSASSPAWEGLDTGYASNRTL 180 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 ++ P G ++W ++E R + +I+ +H+D+RPS +GT+EVR D+ Sbjct: 181 LYQQLPTAGIPYQFASWDEWEEFNRDQDRSGVINHTGSMHFDVRPS-KYGTIEVRFADST 239 Query: 245 LTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 + + ++ + + + + + N+++A RYGL+ +I Sbjct: 240 MAIWEVAAISAYLHCLVVYFERMYDAGEELPSLQQWHVAENKWRAARYGLKALIITDRET 299 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNE 344 R +T++ R +E+++P A ++G + ++ + R + +G + Sbjct: 300 TERMVTDELRRWVEELSPLAEELGCKAELQDVLRLIETGGDY 341 >UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia sp. EuI1c RepID=D1VQ82_9ACTO Length = 901 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 84/340 (24%), Positives = 148/340 (43%), Gaps = 8/340 (2%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + +G+E E +++ L + +++A + AG ++ +S++E + R Sbjct: 6 DTPIPAVGVEEEFHILDLVTRALVPRAGEILEA----LPAGRFTSELLKSVVETNSAPTR 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D+ ++ + AA L GT P R EV + RY + E + L Sbjct: 62 DLAALRADLVDLRHELAAAAEPLGLGPVAAGTVPIVDPDRLEVSRDPRYLQMTEEYQILA 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ + G HVHV D A+ ++ + ++P F+ALSA+SP+ G D+ +AS R ++ Sbjct: 122 REQVICGAHVHVDVGDRDTAMAVIARVGPWLPLFLALSASSPFWLGADSGYASMRTMVWQ 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P G +++ L L + +I +++DIRPS H TVE+RV D + Sbjct: 182 RWPTAGVTGRFQTAAEYDQLVADLVKSGVISDPGMVYFDIRPSAHLPTVELRVCDACPDV 241 Query: 248 SHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG--D 303 V +AGL + E + L + ++A R GLEG + +P G Sbjct: 242 DTVVLIAGLFRGLVSHSVAAIEAGLPVELPRAELLRAATWRAARSGLEGDLVEPSGGGAG 301 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLN 343 P + RLL +I P G + L Q + + Sbjct: 302 PVPAEDLLGRLLAEIRPQLETAGDWELLTELAEQAIQRGS 341 >UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobacteriaceae RepID=D1RSS0_SEROD Length = 369 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 134/367 (36%), Positives = 206/367 (56%), Gaps = 5/367 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M LP F SE TLG E+E+Q+V+ YDLS + +++ V +K +KH++T+SM+E Sbjct: 1 MSLP-FKCSERLTLGTEIELQLVDNDSYDLSHKADRVVEDVDDK---KRIKHELTKSMVE 56 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L + V DI + + + + + +A ++CGGG H W++Q + D+ERY Sbjct: 57 LNSSVHTDIGELLAELNELTGKIRASAQRIDCDVCGGGRHLSNDWRQQVITDSERYTLLA 116 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 FGYL + A VFGQH+H+G GD+A+YL H ++ ++PH IALSA+SP QG DT FAS Sbjct: 117 SRFGYLSKLACVFGQHIHIGVNDGDEAMYLCHAMTPYLPHLIALSASSPLYQGVDTLFAS 176 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR + ++FP+ G + + NW +F + L+ +I+ IKD++WD+RP P GTVEVRV Sbjct: 177 SRFSAQNSFPNYGCLEQIYNWDEFTVYYERLTSAGVIEGIKDIYWDVRPKPELGTVEVRV 236 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPL + HA +AG + A +LL R + + +N+ ACR+G DP Sbjct: 237 CDTPLHIHHAATLAGYCRLLARYLLDNR-QRVIAEYVAFTNYNKINACRHGFGADYVDPA 295 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 T R LT L L + P ++ ++ + V LN+A +R +G Sbjct: 296 TLRRCSLTSHMLATLAALRPGVQNSEENALLDGVEHYVKIALNDADRIRRLRHNGLQQKE 355 Query: 361 LVKKHCE 367 ++K+ C Sbjct: 356 VIKQLCH 362 >UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=Streptomyces sp. AA4 RepID=UPI0001B55095 Length = 364 Score = 374 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 2/360 (0%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 + T GIE E VV+ G L+Q ++ A + GE++H++ +S E+ATDVC Sbjct: 4 QTGDELTFGIEEEFFVVDRDGR-LAQADDVVDRAAETGGENGELQHELIQSQAEIATDVC 62 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 R ++A + +++ + AA + + P EV +N RY+R E+FG Sbjct: 63 RTRDEALRRLRELREDLASAARKRGRRLLPAASPPVSAEDLPEVTENPRYERIGEHFGAT 122 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + + G HVHV + I +L + ++P + ++A S G DT + S R + Sbjct: 123 ARTSLTCGCHVHVAIPDKETGIQVLGRIRPWLPVLLTVTANSAIADGYDTGYRSWRYQQW 182 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P ++ ++E++ + I ++WD+R S T+E R+ D T Sbjct: 183 SRWPSAGPPPRFASLDEYESIVDAWLRSGAILDRGMVYWDVRLSEKQPTIEFRIADVAAT 242 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 AV + L + L + + + + ++A R G+ G P +GD P Sbjct: 243 PEEAVLLGVLARGLVATALADDG-PPPDLPNEVLRAQLWRASRDGVSGCCPHPRSGDLAP 301 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHC 366 E L+E + G Q+ + + A R A+ G +V Sbjct: 302 TKEVLADLIELTTGALESAGDLEFAREATAQLCAEGSGADRQRRRFAERGRGEDVVDLLA 361 >UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PXZ1_9ACTO Length = 351 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 87/352 (24%), Positives = 154/352 (43%), Gaps = 7/352 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 ++G+E E+ +V+ G L + AVK + +V+ ++T + +E+ VC ++ Sbjct: 4 PSMGVEEELLLVSASGEPLPRS-----KAVKEEAEGVDVELELTRAQVEINAPVCDSSDE 58 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + + AA + + P + Q V RYQ +G L ++ Sbjct: 59 LRRHLVDGRTKLAAAAAEEGARLLAVAAPPSGQAL-QLVTKKPRYQEMEARYGQLAREQG 117 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVH+ A+ + + L ++P +AL+A S G DT F+S R ++S +P Sbjct: 118 VCGCHVHIDVPDKAAALRVSNHLRPWLPALLALTANSAVYLGEDTGFSSWRWIMWSRWPC 177 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P+ + + ++ L R I + ++WD RPS H T+EVRV D PLT+ V Sbjct: 178 AGQPPYFESVEHYDRLVRTHLAAGSIMDERMVYWDARPSTHLPTLEVRVSDVPLTVDETV 237 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 +A L +A L + E + + + A R GL G D P+ + Sbjct: 238 LIATLSRALVMTALADGG-PGPELQPEVLRAAYWLAARDGLTGDSVDVLNAQPMPMVDVQ 296 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 L E + P+ ++G +E ++++ N A R + G + L + Sbjct: 297 KLLREHVQPALEELGDLELVEETTERLLTDGNGAVRQRRAFRESGDVTALAE 348 >UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alphaproteobacteria RepID=CAAL_RHORT Length = 389 Score = 371 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 102/369 (27%), Positives = 167/369 (45%), Gaps = 13/369 (3%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLI----DAVKNKITAGEVKHDITESMLELATDV 65 FT+GIE E +V+ L+ D + A G V + + +E+ T V Sbjct: 4 PAFTVGIEEEYLLVDRQSRALAADPPEALMTRLAAAFGDTNHGAVTPEFLRAQIEVGTKV 63 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C + +A A+++V+ + A L THPF +W + ERY E+ Sbjct: 64 CDSLAEAGEALGALRRVLAEEAKGFGLAPIAASTHPFAEWADLKHTPKERYDLLAEDLQA 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 ++++ + G HVHVG D + L+ +S F+PH +AL+ +SP+ +G D+ S R + Sbjct: 124 VVRRLVICGMHVHVGIEDPDLRMDLMAQVSYFLPHLLALTTSSPFWRGEDSGLKSYRIAV 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 FSA P G S++ +++ L +I+ + WDIRPS F T+E+R+ D Sbjct: 184 FSALPRTGLPDSFSSFAEYQRHVEVLVSAGLIEDSTRIWWDIRPSHRFPTLEMRIADVCT 243 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVITDPHTGD 303 L A+ +A L + L R + + Y LL NR++A RYGL+G + D G+ Sbjct: 244 RLDDALCVAALFRCLLRMLYRLRRANQRWRHYARLLIAENRWRAQRYGLDGGLVDFGRGE 303 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA-------DGG 356 P + LLE IAP A G + + + G + +R F Sbjct: 304 VVPFADLIEELLELIAPDAAVFGCQAEVLHARTILHRGTSAHNQLRVFAEARAGGMTRDE 363 Query: 357 SLIGLVKKH 365 +L+ +V Sbjct: 364 ALVAVVDHL 372 >UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostocaceae RepID=CAAL_ANAVT Length = 387 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 106/377 (28%), Positives = 172/377 (45%), Gaps = 10/377 (2%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M +F S F+LG+E+E+Q++NP L S L+ ++ + ++M+E Sbjct: 1 MGDIEFKSSPEFSLGMEIELQLLNPDTLQLVDGISPLLAQTPENSW---IQPEFNQAMVE 57 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +A+ VC +I + A+ + + + IC GT+P + + RY Sbjct: 58 IASQVCSNIPELEANIVAILRDLKTRCQALGMTICTAGTYPCCD-RFASITPIPRYLSQQ 116 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 GYL +HVG SGD AI ++ L ++P +ALSA+SP+ G DT FAS Sbjct: 117 NTSGYLADLMMTCALQLHVGMPSGDVAIDIMGRLKPYLPILLALSASSPFWWGHDTSFAS 176 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R S+ G P NWQ F F M + I+D+HWD+RP P FGT+EVRV Sbjct: 177 FRQRFLSSMRTYGICPTFKNWQDFTNFFATAQNAGMFEIIRDIHWDLRPQPDFGTLEVRV 236 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTER-----PFKHQEKDYLLYKFNRFQACRYGLEGV 295 MD T+ ++ +A I + + F +L+ + N F+A R+GL+ Sbjct: 237 MDAQPTIKESMMLAAFIHSLIVDMYHHSQGKQTEFLLTPLPWLIERENYFRASRWGLDAN 296 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + G+ RP+ +L +A +A +G SS + L +++ G + R Sbjct: 297 YIEDEQGNSRPIRNIVKDILNVLAETADTLGNSSYLFQLEKRLDQGAS-YIRQRRVFEST 355 Query: 356 GSLIGLVKKHCEIWAGD 372 GS+ +V + Sbjct: 356 GSVKAVVASLVSELEAE 372 >UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales RepID=D2BAT9_STRRD Length = 386 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 97/364 (26%), Positives = 163/364 (44%), Gaps = 4/364 (1%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F P +G+E E VV+P ++ +++ +++ ++ +V +IT +E T Sbjct: 11 PTFDALCPL-VGVEEEYLVVDPSTRAVAPEAAGVVERAAAEL-GEQVSTEITRFQVEAKT 68 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 C DI++ G+ M+ + AA L + GT + + D+ RY ++ + Sbjct: 69 PPCADISELEGRLRRMRSAMAAAARAGGLAVVASGTPVLGEVVPPPITDHPRYDVGIDTY 128 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L + ++ HVHV + A+ + + L ++P IAL A SP+ G DT +AS R Sbjct: 129 RALHDEQSICAGHVHVHLPDRERAVLVSNHLRPWLPVLIALMANSPFWAGRDTGYASWRT 188 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 + +P GP P+ ++ +FE L L+ ++ + WDIRPS T+EVRV D Sbjct: 189 LSWGKWPVAGPPPYFASLAEFEELIGTLTGAGVLVDPGTIFWDIRPSARLPTLEVRVTDV 248 Query: 244 PLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 P T + +A +++A L + L + +QA R GLEG DP T Sbjct: 249 PATAEESALLAAVVRALVVVSLERVDSGDPGPRLSAELLRAAYWQAARDGLEGQGIDPLT 308 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 G P E LL I PS + G + A +++ + + A R G + Sbjct: 309 GRLAPAAELCEALLRHIGPSLERTGDLETVTARLKRLRAAGSGAARQRAAHDRRGRPADV 368 Query: 362 VKKH 365 V Sbjct: 369 VDHL 372 >UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environmental samples RepID=C0INB1_9BACT Length = 384 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 83/361 (22%), Positives = 144/361 (39%), Gaps = 9/361 (2%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P+ +GIE E V + ++ + S K V ++ +S +E+ T C + Sbjct: 12 PYRIGIEEEYFVSDLRTGNVRRIMSKAFYNACEKELGEAVTPELLQSQIEVRTPPCGTMQ 71 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A S ++V+ + A H L I GTHP W Q+ + ERY E+ L + Sbjct: 72 EARDHLSHYRRVLAREAVRHSLAIVASGTHPLAIWHEQQQTEKERYGEVREDLQMLAMRN 131 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV + + +++ L F+P +ALS +SP+ QG T R + P Sbjct: 132 MVCGMHVHVEVPDPESRVGIMYRLMPFLPPLLALSTSSPFWQGYRTGLLGYRLTAYDELP 191 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G N +++ L+ +I L W +RPS T+E+RV D + Sbjct: 192 RTGLPELFRNAEEYRRYVDTLTEAGVIKDASFLWWAVRPSLAHPTLELRVADCCTHVEDT 251 Query: 251 VNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A + + L+ E + N+++A RYG D RP+ Sbjct: 252 LAIAAIYRGLMRHLVEHAELNADLDVVGRAVAMENKWRAQRYGTAATFIDARARTARPIA 311 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV-------ADGGSLIGL 361 + +LE I + + + G + Q +R + + +L + Sbjct: 312 DVLRYILELIRADTDALDCTKEAAHAFEILKRGSSADQQIRVYRTARDAGASRPKALKDV 371 Query: 362 V 362 V Sbjct: 372 V 372 >UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salinispora RepID=CAAL_SALAI Length = 378 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 148/362 (40%), Gaps = 5/362 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++ + ++ ++D + + + + + SM+E+ T V D+ + Sbjct: 15 LTLGVEEEFLLLDAETGESMPVAARVLDGLSG-VAHAQSRREFRHSMVEMVTPVLSDLAE 73 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 A++ AA + G P + R V D RY FG + Sbjct: 74 LRRHLVALRTAAADAAEAAGARLVAVGATPVNETHRT-VPDEPRYHAMSRRFGPVAHDPA 132 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + + L ++P A++A SP G DT AS R +P Sbjct: 133 VCGCHVHVGLPDRELAVQVCNHLRPWLPVVQAITANSPLHDGQDTGHASWRAMQLERWPS 192 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P+ + ++A L ++ ++W +RPS + TVE+RV D T+ V Sbjct: 193 IGPTPYFDSAADYDATVADLIKAGIMLDAGMVYWYVRPSAAYPTVEIRVGDVCPTVDDTV 252 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +AGL++A + + + L ++A GL+G + D TG RP + Sbjct: 253 LVAGLVRALVATVAADVHDGARAPRIRGCLLSAAHWRAAHDGLDGDLVDLRTGRARPAWD 312 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG-SLIGLVKKHCEI 368 L + P+ + G + + +V + A R + + ++ Sbjct: 313 LVDDLFALVTPALERQGDRAYVRDQLARVRAEGTGAVRQRRILDRSACDVRAVLDHLAAQ 372 Query: 369 WA 370 Sbjct: 373 TR 374 >UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL2_RUBXD Length = 363 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 165/365 (45%), Gaps = 6/365 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F S P+T+G+E E Q+++P L+ ++ A ++ G + +++ S LE+ T Sbjct: 5 FGASPPYTVGVEEEFQLIDPRTRALTPKIEEVLAAGDGELPEGTLASELSASCLEVRTPA 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + + A A++ V + A + G HPF Q + RY++ E G+ Sbjct: 65 YASVAELARALPALRARVRRLAERSGARLVSAGAHPFSPAAEQPITGKPRYRKVDEEMGW 124 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++G HVHV G++A+ + L+R VP FIALSA SP+ +G DTR AS R + Sbjct: 125 PARMQAIYGLHVHVAVPGGEEAVRAVSALARHVPLFIALSANSPFWEGRDTRLASVRAKV 184 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 F P +G P ++W++F L I WD+RP P GTVE+R D Sbjct: 185 FGLIPRSGLPPRFASWEEFVRHVERLVRAGSIRDYTFCWWDVRPHPKLGTVELRAPDAQT 244 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +A L + + +D LL + N+++A R+GLE + D Sbjct: 245 DPGRTAALAA-----LCQCLAAAAEEFEPEDPLLTEENKWRATRHGLEAELYDFSGQRTV 299 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 L+ ++ P A ++G + +E + + A R +A GSL +V Sbjct: 300 AARRAAEELVGRLLPVARELGCEAELEGVLE-ISRSATGADRQRAVLAREGSLKSVVDYL 358 Query: 366 CEIWA 370 E A Sbjct: 359 AEATA 363 >UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SDE2_9ACTO Length = 380 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 148/358 (41%), Gaps = 5/358 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++P + + + A+ + + + SM+E+ T V D+ + Sbjct: 19 LTLGVEEEFLLLDPATGESMPVADRVRGALSG-TAREQSRQEFRHSMVEMVTPVSPDLGE 77 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 +++ QAA + G P + R V D +RY FG + Sbjct: 78 LREHLVTLRQAAAQAADAAGARLVAVGATPVCEAHRT-VPDEQRYHDMSRRFGPVAHDPA 136 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + + L ++P AL+A SP G DT AS R +P Sbjct: 137 VCGCHVHVGVPDRELAVQVCNHLRPWLPVVQALTANSPLHDGRDTGHASWRSMQLERWPS 196 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P + ++A L ++ ++W RPS + TVEVRV D T+ V Sbjct: 197 IGPTPHFESAADYDATVADLITAGIMLDAAMVYWYARPSAAYPTVEVRVGDVCPTVDDTV 256 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +AGL++A L+ + L ++A G++G + D +G RP + Sbjct: 257 LVAGLVRALVATLIDDVRAGVPAPRIRDCLVAAAHWRAAHDGVDGKLVDLRSGRPRPAWD 316 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA-DGGSLIGLVKKHC 366 L+ + P+ + G + +V A R +A GG + ++ Sbjct: 317 LVDDLVVTVTPALARHGDLDLVRRELDRVRRDGTGATRQRRIMAGTGGDVRAVLDHLA 374 >UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WA32_ACTMD Length = 363 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 96/366 (26%), Positives = 158/366 (43%), Gaps = 6/366 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +++P+T+G+E E +V+P + + D +V+ ++T +E+AT VC Sbjct: 1 MTQPWTVGVEQEFLLVDPQTRRPVPLAEAVADRAGASF---DVQRELTPFQIEVATPVCH 57 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A Q A ++ + +AA + P + ++ RY R ++ Sbjct: 58 SSAELAEQVLAGRRHLAKAARAAGGALMASAVPPLGMTGPPSITEDARYLRMQYTHRKML 117 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 V G HVHVG + AI + L ++P +ALSA SP +G DT ++S R ++S Sbjct: 118 AGQGVCGMHVHVGVPDRETAIRASNALRPWLPSLLALSANSPVEEGQDTGYSSWRSIVWS 177 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P + ++AL L T ++ ++WD+RPS H TVE+RV D PLT Sbjct: 178 RWPVGGPPPQFTGAGHYDALVSALVGTEVVLDPAMVYWDVRPSTHVPTVEIRVADIPLTA 237 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV +A L++A P + + +L + ++A R G +G DP TG P Sbjct: 238 KDAVVIAELVRAFVRTAADSAPTE--PVNDVLLRAAYWRAARDGADGQGIDPRTGSLVPA 295 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG-GSLIGLVKKHC 366 + LL + GA + V A R +G +V Sbjct: 296 RDLLAELLAFGEDALRDAGAQDLVRGHLAAVAEHGGGAAKQRRAFLNGEADPADVVDLVL 355 Query: 367 EIWAGD 372 D Sbjct: 356 AETTAD 361 >UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Mycobacterium RepID=CAAL3_MYCS2 Length = 365 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 82/368 (22%), Positives = 154/368 (41%), Gaps = 6/368 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +S T G+E E +V+P + + + + K +++ ++T +E AT+V Sbjct: 1 MSNNPTFGVEEEFLLVDPRTGEPIARNKAVAETAAAK--GVDLQLELTSCQVETATEVMD 58 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + + +++V AA + + G P + + RY+R FG + Sbjct: 59 NSDDLRKALLRLRRVATDAAETNGARLLAAGLPPTV-PHKFPITPTPRYRRIGHRFGMIA 117 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + + G HVHV S D AI + + L ++ +AL+A S +G+D+ +A+ R +++ Sbjct: 118 HEQGICGCHVHVEVPSRDAAIRVSNRLRPWLHLLLALTANSAIYRGSDSGYATFRSVLWA 177 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P+ + Q++A L ++WD+RPS F TVEVRV D P T+ Sbjct: 178 RWPSAGPPPFFDSEAQYDATVAMLEDAGAALDDGMIYWDVRPSNKFPTVEVRVSDVPATV 237 Query: 248 SHAVNMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDP-HTGDR 304 + V A L++A + K +++ R GL+G D + Sbjct: 238 AETVLFATLVRAAVMTATEAEKNGEPVVPLTDYVLKAAYWKSARDGLDGRTIDLAESHAV 297 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P E +E + P+ ++G + +V+ N A R ++ + Sbjct: 298 APTVELLTNFVEHLRPALEQLGEYDTVRGELARVIETGNGAMRQRRAFERRREAADVIDE 357 Query: 365 HCEIWAGD 372 + Sbjct: 358 LAAATIAE 365 >UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6WDG9_KINRD Length = 850 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 90/363 (24%), Positives = 161/363 (44%), Gaps = 7/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG E E+ +++ LS + ++ + ++ + +E TDV + + Sbjct: 1 MTLGAEEELHLIDLGSGQLSARAPQVLSRLDP----ASYSAELQRTTVETNTDVVTSLTE 56 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++K +++AA L + GT P + E+ RY R E + L+ + Sbjct: 57 LREELLRLRKGLVEAAARDGLGVAAVGTAPRSTFTDFELTATGRYGRMQEQYRLLVDEQL 116 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G VHVG + D A+ ++ ++ +P +ALSA+SP+ G DT +AS R ++ +P Sbjct: 117 ICGTQVHVGVSDRDLAVEIMQRVAPSLPVLLALSASSPFWNGQDTGYASIRTTVWQRWPT 176 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G + + Q++ L L + +I K ++D+RPS H T+E+RV D + AV Sbjct: 177 AGSTGPLESAAQYDELLADLIASGVIGDEKMAYFDVRPSSHAPTLELRVADACPLVDDAV 236 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG-DRRPLT 308 +AGL +A + + L++ +QA R GL G + D P Sbjct: 237 LIAGLFRAGVRAAELDVLAGRPRPQVPSPLHRAGIWQAARGGLSGNLLDGTEHPRPVPAP 296 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 E LL ++ P ++G + L ++ N A R + G L +V+ E Sbjct: 297 EAVRALLTRLRPQLEELGDWEEVAELTEATLARGNSADRQRAAFVERGELDDVVRLVVEE 356 Query: 369 WAG 371 G Sbjct: 357 TRG 359 >UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp. oral taxon 848 str. F0332 RepID=D0WKA5_9ACTO Length = 387 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 98/363 (26%), Positives = 160/363 (44%), Gaps = 5/363 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 F SE T+G+E E+Q+V+P L ++ ++ V+ + VK ++ ++MLE + Sbjct: 4 AFRDSERSTVGLEWEVQIVDPKTLKLGHNAKWILAEVRRR-GCSLVKGEMHQNMLEFVSR 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 + + A L A + + GGG+HPF Q V + RY+ +E Sbjct: 63 KRVSVAECAADMEEAIDAALPYAEELGVGFSGGGSHPFAHPSDQPVSETARYRELVERTR 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 Y +Q +FG HVHVG + + LS + H + +SAASPY DT +A +R Sbjct: 123 YWGRQMVIFGTHVHVGVEDRRKVAPIHNFLSAKIGHLLGISAASPYWDDVDTGYADNRAM 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +F P G +++W E + L I ++ WD+RPSP FGT+EVR D+ Sbjct: 183 MFQQLPTAGLPMHLNSWGDLERIAGDLVDVGAIREYNEIRWDVRPSPGFGTIEVRACDSA 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQ--EKDYLLYKFNRFQACRYGLEGVITDPHTG 302 L+ +A + A E + L + N+++ RYG + + G Sbjct: 243 TNLAEIRAIAAFVHALVETASRELDAGRPLLSLPFHLLETNKWRGARYGAHAELVESADG 302 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 + PL E LL I P+A +G + + A+ + S A +R G L + Sbjct: 303 ECAPLAETLPDLLAWIEPAAEFLGCAEDLAAVPELIAS--PAADRLRAAAGPDGDLKAVA 360 Query: 363 KKH 365 Sbjct: 361 AHA 363 >UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micrococcaceae RepID=CAAL_MICLC Length = 398 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 102/362 (28%), Positives = 160/362 (44%), Gaps = 11/362 (3%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVK------NKITAGEVKHDI 54 M LP F S TLGIE E+ +V+ +L ++ L+ A+ + + ++ Sbjct: 1 MTLP-FADSAQSTLGIEWELALVDAVSGELRSEAPDLLRALHVAEGLADDDVNPHMTSEL 59 Query: 55 TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE 114 ++ +EL T V ++ A + V AA + + GTHPF Q +E Sbjct: 60 LQNTVELVTGVHERVDAATADLGRIAARVADAAAARGISLFCQGTHPFADAIAQPSTPSE 119 Query: 115 RYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 RY R L+ Y +Q +FG HVHVG A+ +++GL VPH +ALSA+SP+ GT Sbjct: 120 RYDRMLDLTQYWGRQLLIFGVHVHVGLDDVSKAMPVVNGLVNRVPHLLALSASSPFWAGT 179 Query: 175 DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFG 234 DT + S R +F P G W+ FE + MI + + WD+R P G Sbjct: 180 DTGYQSQRTLLFQQLPTAGLPFQFQEWEDFERCVAQMEQVGMIADVTECRWDVRAVPRLG 239 Query: 235 TVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGL 292 TVE+R D TL + Q L ER + + N+++A RYG+ Sbjct: 240 TVEMRACDGLATLEEIAAVTAYTQCLVDDLSASLERGETVEVLPPWHAQENKWRAARYGM 299 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + + G + PL E +E++ P A ++G + + + + G A R Sbjct: 300 DATVIVDARGTQVPLAEHLPAEIERLTPVAERLGCEAELAGVQAMIDDGG--AARQRRVE 357 Query: 353 AD 354 A Sbjct: 358 AQ 359 >UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rhodococcus RepID=CAAL1_RHOSR Length = 369 Score = 360 bits (924), Expect = 6e-98, Method: Composition-based stats. Identities = 81/362 (22%), Positives = 153/362 (42%), Gaps = 6/362 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++G+E E +V+ LS ++ + I ++ ++ +E AT VC Sbjct: 7 ESGRDLSVGVEEEFFLVD-ESGHLSAAGPDVVTEAGHDIHG--LQRELARCQIETATGVC 63 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 + + ++++ + +AA L + GT + + + RY+ +FG + Sbjct: 64 HTGEELHEELRSLRRRLAKAAAGRDLLLLPSGTSLVVEGLPPAITPSPRYEEMARHFGSI 123 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + T G HVHVG S D + + + + ++P +AL+A SP+ G DT + S R ++ Sbjct: 124 VDTVTTCGCHVHVGIPSRDVGVRVSNLVRSWLPVLLALAANSPFHSGHDTAYHSWRHIMW 183 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P + ++EA + T ++W +R + T+EVR+ D +T Sbjct: 184 SRWPSAGPPPHFDSADEYEATVGAMIGTGAAMDRGMIYWHVRLADKQPTIEVRIADVAMT 243 Query: 247 LSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 +HA A +++ W L + L + ++A R GL+G T P Sbjct: 244 AAHAALYAVVVKGLVGWALQSLDDGLTVPWLRAELLRAQLWRAARDGLDGECTSPAADRV 303 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P+ L + +AP + +E+ V+ A+ R G+L +V Sbjct: 304 LPIRRQLELLNDCVAPGLGPS-DRAFLESGLDTVLREGTGAERQRAEFTRVGTLAAVVDL 362 Query: 365 HC 366 Sbjct: 363 LT 364 >UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alphaproteobacteria RepID=CAAL_BRASB Length = 408 Score = 357 bits (916), Expect = 5e-97, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 153/359 (42%), Gaps = 4/359 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++ GIE E + + D++ + + N T G+ ++ ++ +E+AT+V Sbjct: 29 EDVTEYSFGIEEEYFLADARTLDVAIRTPDDLFEAANWSTGGQAMREMLQAQIEVATNVH 88 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 D A + +++ V A + L I THP W+ + RY +E+ + Sbjct: 89 VDSRDAREELKFLRREVASVAGQYGLTILACSTHPTAMWRSSQPTPRPRYAEMMEDLRIV 148 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 Q+ + G HVHV + ++ + ++P FIALSA+SP+ +T R + Sbjct: 149 GQRNMLCGMHVHVQLPDSERRFAVMRAMIPYIPVFIALSASSPFWNSRETGLKGYRLAAY 208 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 P G ++ +++ L+ + ++ + W +RPS T+E+R D + Sbjct: 209 DELPRTGLPELFTSKPEYDRYVAALTRSGVMPDESHVWWAMRPSLRHPTLELRAPDVCTS 268 Query: 247 LSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + AV +A L +A A +L + + + N+++A RYG + + Sbjct: 269 VDDAVAVASLYRALARHLYLHPDLADAVGNVERAIAVENKWRAQRYGTDCLFV--AEEGP 326 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 E R++ IAP A + + +E + G + ++ + GG L +++ Sbjct: 327 VTGQEILNRMIADIAPHAEALDCLAEVERCRTIMQFGSSADYQLQAYRESGGELSAVLR 385 >UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1AAX9_THECD Length = 371 Score = 356 bits (913), Expect = 9e-97, Method: Composition-based stats. Identities = 81/367 (22%), Positives = 155/367 (42%), Gaps = 12/367 (3%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVK--------NKITAGEVKHDITESMLELATD 64 + G+E E+ + +P G S ++ + + +T G ++ ++ LE+ T Sbjct: 5 SFGVEEELLLFDPEGGAPRAMSGAVLHHARLQGEKVHTSPLTKGGMESELQREQLEICTR 64 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 C +++ Q + +AA + I T P + ++RY++ + + Sbjct: 65 PCTTLDELDRQVRRRRLAAARAAAAAGVRIAALATSPVA--AHPTLTPHDRYRQMADQYA 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 + + + G HVHV +S ++ + +L + ++P +ALSA SP+ QG DT + S R Sbjct: 123 QVADEQLICGCHVHVEVSSPEEGVGVLDRIGPWLPPLLALSANSPFWQGRDTGYDSWRRQ 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +++ +P +GP + + R L T + +++D R S H+ TVEVRV D Sbjct: 183 VWARWPSSGPAEPFRSADGYRRAVRALIETGALLDEGMVYYDARLSRHYPTVEVRVADVC 242 Query: 245 LTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 + V +A L++ + + ++A R GL G + P T Sbjct: 243 MRADDTVLIAALVRGLVETAARAHREGRPPVPVRTEVLRAAMWRAGRSGLSGALVHPVTW 302 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 P L+E + P+ G +A+ L + + N A L R A G + G++ Sbjct: 303 RPAPARTVLQALVEYLRPALEDAGDLAAVRELLQALARRGNGACLQRTAYARTGCISGVI 362 Query: 363 KKHCEIW 369 + Sbjct: 363 ADAMDRT 369 >UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YFK1_NOCDA Length = 390 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 95/362 (26%), Positives = 156/362 (43%), Gaps = 4/362 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P T G+E E VV+P + + ++ ++ + + + + +E + VC D Sbjct: 27 PPTFGVEEEFFVVDPGTRLILSRAPEVL--ANTRVLGDHLCGEFSRAQVEANSPVCDDAG 84 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A A + + +AA L + GT + RY +FG L + Sbjct: 85 EALRFLRAARGELDRAAGAAGLAVVASGTAVLGDPASVGTSEGRRYADITAHFGALRESH 144 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHVG + A+ + + L R++P +ALSA SP+ G DT ++S R ++ P Sbjct: 145 VVCGCHVHVGVPDRETAVAVGNHLRRWLPFLVALSANSPFHAGRDTGYSSWRTVAWNRLP 204 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP P++ + + E R LS + I + ++WD+R S H T+E+RV D T A Sbjct: 205 SAGPPPFLRSLAEHEQAVRALSDSGAILDRRMVYWDVRLSDHLPTLEIRVSDVAATAEEA 264 Query: 251 VNMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A L++ L + + ++A R GLEGV+ DP TG+ P Sbjct: 265 LLLALLVRGLTGRALADVLYGVPAPAIPDQALRAAVWRAARDGLEGVVPDPLTGEALPGH 324 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 RLL P G + +L +V + + A R A G L +V Sbjct: 325 AAAERLLHAAMPGLLANGDADLASSLLDRVRAAGSGAARQRAVYARRGRLADVVDHLVVQ 384 Query: 369 WA 370 Sbjct: 385 TR 386 >UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellular organisms RepID=CAAL_BORPD Length = 415 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 147/373 (39%), Positives = 210/373 (56%), Gaps = 4/373 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F S P TLGIELE+Q++NP +DL+ + L+ + N A VK +IT SM+E Sbjct: 1 MEQIPFVSSAPNTLGIELELQLINPRSFDLAAAADELLAQMANHPIADRVKPEITRSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L + V + M+ + AA + + GGG HPF +WQ + + D+ R+Q Sbjct: 61 LNSSVHEHPMGLLAEMREMRDALCDAADAVGVSVAGGGAHPFMRWQERAISDSPRFQYLA 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +GYL +Q TVFGQH+H+G SGD A+ ++ GLS +VPHFIALSA+SPY +G DT F+ Sbjct: 121 EMYGYLARQFTVFGQHIHLGVPSGDAAVRMVRGLSPYVPHFIALSASSPYYEGVDTLFSC 180 Query: 181 SRPNIFSAFPDNG-PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 R N S+FP G V++W +FEA L + +SIKDL+WDIRP P FGTVE+R Sbjct: 181 CRLNAVSSFPLAGHLPADVTDWYRFEAHIAQLRACGLAESIKDLYWDIRPKPEFGTVEIR 240 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 V DTPLT+ A +A A A +L R + +L Y+ N FQACR+GL+G P Sbjct: 241 VCDTPLTVERACQLAA--FAQALAVLVTREPEPAPAAWLAYRSNHFQACRFGLQGSYVTP 298 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 G R L + L +++ P A ++G + AL + + N+A+ +R L Sbjct: 299 -DGQRLRLIDHLRALFQRLMPIADELGTGDMLVALRDESIRNGNDARWLRSQFHRLRDLP 357 Query: 360 GLVKKHCEIWAGD 372 +V+ W G+ Sbjct: 358 LVVESMTHAWRGE 370 >UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0F2E7_9PROT Length = 371 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 104/367 (28%), Positives = 169/367 (46%), Gaps = 5/367 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F S P TLG+E+E V+ + + + AV + +K ++ S +E Sbjct: 5 MRTIAFQDSSPGTLGVEMEWMTVDINSGEQVPAAPAVFAAVGE---SARIKPELFTSTVE 61 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + TD+ R + A + A+ V Q H + GTHP W+ Q+V D++RY R L Sbjct: 62 INTDIHRSTSAAVDELQALYDQVSQILGGQHAALLSAGTHPTSHWRDQQVTDDQRYARLL 121 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +++++ +FG HVH+G GD I ++ L +P F+A+SA SP+ QG DT ++ Sbjct: 122 ERLQWMVRRFNIFGIHVHIGMPDGDTCIRAMNHLLPIMPVFLAISANSPFWQGEDTGLSA 181 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR +F G + NW+ FE L T IDS++D+ W++RP P FGT+EVR+ Sbjct: 182 SRIKVFEGLSQGGMPFYFENWRDFEHCAGRLQATDSIDSVRDIWWEMRPHPDFGTLEVRI 241 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D P + + ++A A + L + NR++ACRYG+ G + DP Sbjct: 242 GDMPGSRADTQAYIAYVRAEAMAAMHTEAVPRVHPS--LIRENRWRACRYGMHGTMIDPF 299 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 T P+ + L +A + + A + R A + Sbjct: 300 TERLMPVLDWLEMRLGALAAGGIEQSELELVAGRIGHWRKHAGGAAMQRQLHATHAAFPA 359 Query: 361 LVKKHCE 367 ++ E Sbjct: 360 MIAAMRE 366 >UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xanthobacteraceae RepID=CAAL_AZOC5 Length = 386 Score = 352 bits (905), Expect = 9e-96, Method: Composition-based stats. Identities = 78/362 (21%), Positives = 139/362 (38%), Gaps = 5/362 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + + +S + GIE E VV+ + + ++ +S LE Sbjct: 7 LASREVRMSNDYRFGIEEEFFVVDAETKAALRRMPSGFFDALRDRLGDSITVELLQSQLE 66 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +AT I A + ++ + + A +H L GTHP W RY + Sbjct: 67 MATAPTDRIGDALDELRDLRHIAGRVAAEHGLGFIAAGTHPTASWDNVRATKANRYDGLM 126 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 ++ L ++ V G HVHV D + ++ ++ ++PHFIALS +SP+ T Sbjct: 127 QDLQMLGERNMVCGLHVHVELPDPDLRVDVMRRITPYLPHFIALSTSSPFWGSRQTGLMG 186 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R + P G + +E L I + W IRPS T+E+R Sbjct: 187 YRLAAYDELPRTGLPELFEDNAAYEEYVAALVGARAISDSSYVWWAIRPSQKHPTLELRA 246 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKH--QEKDYLLYKFNRFQACRYGLEGVITD 298 D + AV +A L ++ +L+ D + N+++A RYG+ G D Sbjct: 247 PDACTRVEDAVALAALYRSLVRFLVRHPEHHRHIGAVDRAIANENKWRAQRYGIHGSFVD 306 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLM---RDFVADG 355 + + +L+ +A A +G A+ L +G + + ++ Sbjct: 307 LAEQRAIQVRDALDQLIALVADDAEDLGCLDALLHLRTIPDAGTSADMQIAVYQEAHHRT 366 Query: 356 GS 357 G+ Sbjct: 367 GN 368 >UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces RepID=B4V462_9ACTO Length = 381 Score = 350 bits (898), Expect = 5e-95, Method: Composition-based stats. Identities = 84/363 (23%), Positives = 149/363 (41%), Gaps = 5/363 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P T+G+E E +V+ + + +++D E+ + T +E++T V Sbjct: 19 PLTVGVEEEFLLVDTRTLRVVPAAPLVLDTAAGLPH--ELHPEGTRYQVEISTPVAHSAV 76 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN-ERYQRTLENFGYLIQQ 129 + +A+++ + +AA H + + + D+ R + FG L Sbjct: 77 TLRAELAALRRTLARAARAHGCRLLAAPSPVVALEGPLHLTDDEPRQREQHRRFGALTDT 136 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 G+HVH+G D A+ + + + ++P IAL+A SP+ G DT AS R ++ + Sbjct: 137 LVSCGRHVHIGTLDVDTAVAVSNRVRPWLPTLIALAANSPFWGGRDTGHASWRAMAWAGW 196 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G P ++ F + L + K ++WD+RPS H+ T+E+R D + Sbjct: 197 PSAGLPPHFTSTAHFRRSVQNLLGSGAALDTKMVYWDLRPSGHWPTLEIRAPDMSPDIDT 256 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEK--DYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV A L +A L E E + + R++A GLEG DP+TG P Sbjct: 257 AVLQAELARALVAKALQEISEHRPEPAIRDDVLRLARWRAAHDGLEGFGLDPYTGAELPA 316 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 LL+ +A G ++ + A R A L +++ + Sbjct: 317 AGLAEALLDHVAADLAVAGDLDHAAKTMAGLLRDGSGAHRQRAAYARRQDLNDVLRHLAD 376 Query: 368 IWA 370 Sbjct: 377 ETE 379 >UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RCL6_9ACTO Length = 372 Score = 350 bits (898), Expect = 6e-95, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 150/360 (41%), Gaps = 3/360 (0%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E VV+ + ++ ++ A + V +IT LE TD C + + A Sbjct: 14 FGVEEEFLVVDAVTRAPAPRAAEVVAAASASL-GDRVSGEITTLQLETRTDACGTLGELA 72 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 Q +KVV A L + GT P + R R E + L + + Sbjct: 73 DQLDEARKVVADCARAAGLRVVATGTAPVAGAVPPPMTVGPRQSRGTETYRGLHDELALC 132 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 HVHV A+ + + L ++P + L+A SPY D+ +AS R ++ +P G Sbjct: 133 ALHVHVEMPDRQRAVLVGNHLRPYLPLLLTLTANSPYWDDRDSGYASWRTTVWGRWPVAG 192 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 P P + + ++ + R L + + WD+RPS T+EVRV D+ +T + Sbjct: 193 PPPVFDSAEHYDEVVRRLLDAGALVDRATIFWDVRPSERHPTLEVRVADSAVTAEDSARY 252 Query: 254 AGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 A L++A L + L + ++A R GL+G DP TG RP E Sbjct: 253 AALVRALVVHLAAVMDAGEPAPHVAGELLRVGYWRAARDGLDGEGLDPRTGRLRPAAELA 312 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 LL+ + P G + ++ + A+ R V GG+L +V E AG Sbjct: 313 RHLLDTVEPVLRAHGDYDPVAQWLERLGTDGTGARHQRAVVRRGGTLTDVVDHLAERTAG 372 >UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1A6U3_THECD Length = 372 Score = 346 bits (889), Expect = 7e-94, Method: Composition-based stats. Identities = 101/365 (27%), Positives = 157/365 (43%), Gaps = 4/365 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 E G+E E V++ + +I+ ++ V +IT +E T C Sbjct: 4 DGEALRFGVEEEFLVIDRRTRATVAGAPAVIERAAARL-GDRVCGEITLVQVESRTRPCT 62 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + AGQ +A + + AA L + GT + + R R F L Sbjct: 63 TAAELAGQIAANRAHLAAAADGGGLGVIASGTPVLGGAVPSPITEGPRQNRGNATFRGLH 122 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +A HVHV A + A+ + + L +P IAL A SPY DT +AS R ++S Sbjct: 123 HEAAFCALHVHVEMADRERAVRMSNHLRPHLPVLIALGANSPYWCERDTGYASWRTLLWS 182 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P++ + + ++ L + + + ++ WDIRPS H T+EVRV D P+T Sbjct: 183 RWPVAGPPPYLESAEHYDTLVATMQEAGALVDVGNVFWDIRPSAHLPTLEVRVSDVPITA 242 Query: 248 SHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + +A L++A LL +R L + ++A R GL G D HTG Sbjct: 243 EESAALAALVRALITSLLPAVDRGEDGPHLRPELLRLAYWRAARDGLSGSGVDVHTGKLL 302 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P E RLLE P + G + R+++ + A R A GG L G+V Sbjct: 303 PAVELAERLLETARPGLERHGDLGRVTGWLRRLIEHGDGASRQRRA-ARGGGLTGVVDHL 361 Query: 366 CEIWA 370 + A Sbjct: 362 LQQTA 366 >UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actinomycetales RepID=CAAL2_SACEN Length = 391 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 91/363 (25%), Positives = 146/363 (40%), Gaps = 7/363 (1%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE---VKHDITESMLELATDVCRDI 69 T+G+E E +V+ L+ + ++ N + ++ S +E AT CR + Sbjct: 22 TIGVEEEFLLVDAASGQLAPHAEAVLAEAANGPLGAPDAVLHAEMLNSQVEAATGCCRTL 81 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + Q A + + +AA+ I GT + +R+ E + + Sbjct: 82 EELRSQLVAARTSLDRAASVAGARIVSSGTPVLAVEGTG-TSNGQRFADIAERYRAVASD 140 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG D A+ +++ L ++P +A+SA SP+ G DT AS R + Sbjct: 141 YHVCGCHVHVGVPDRDTAVAVVNHLRPWLPTLLAISANSPFHLGHDTGHASWRGVQQRLY 200 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P +G P + ++ L + + W RPSPH TVE+RV D +T Sbjct: 201 PGSGVPPHFPSRDAYDREVARLVDCGALVDDRMSFWMARPSPHLPTVELRVADALITAEE 260 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 V A L +A L + + E + + A RYGL G DP R P Sbjct: 261 TVLQAALSRALVRAALDDLAAGREGDEVSDQVAAAAVWNASRYGLRGPAVDPVPARRVPA 320 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 E RLL ++ P+ + G S+ + V ++ R A GG +V Sbjct: 321 LEMVERLLRRVGPALEQTGDSALVREALAHVTGVGTGSERQRAAAAAGGP-REVVAMLAA 379 Query: 368 IWA 370 A Sbjct: 380 ATA 382 >UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D2S6F8_9ACTO Length = 386 Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats. Identities = 88/380 (23%), Positives = 141/380 (37%), Gaps = 25/380 (6%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA---------------------GEVK 51 T+G+E E+ VV+ G + + L A + G + Sbjct: 7 TVGVEEELLVVDSSGRPVPLGPAALEVAARRGEGETVEEHDRAERGDDEAGGGDPVGRLV 66 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 ++ LE T VC ++ A + AA D + + P + Sbjct: 67 PELKTQQLEFGTRVCTGLDDVAADLRHWRGRADAAARDVGARVAALASSPV--RVEPQST 124 Query: 112 DNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM 171 ERY E F + G HVHV ++ + +L+ + ++P AL+A SP+ Sbjct: 125 PGERYTEMAETFRLTAAEQLTCGCHVHVAVEDDEEGVAVLNRIRVWLPVLTALTANSPFW 184 Query: 172 QGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP 231 G D+ AS R ++ +P +GP ++ + L L T I +++D R S Sbjct: 185 LGRDSGHASYRAQAWNRWPSSGPNELFADAAAYHRLVGELLATETIVDTGMVYFDARLSE 244 Query: 232 HFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACR 289 + TVEVRV D L AV +AGL++ + + ++A R Sbjct: 245 RWPTVEVRVADVALRAEDAVTLAGLVRGLVETAAGQWRAGVPAPAVRSEVVRMAAWRASR 304 Query: 290 YGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMR 349 GL G + P TG P LL + P+ G + A V+ A L R Sbjct: 305 SGLTGDLVHPATGRPAPAGAVVTALLAHVRPALAAAGDEQRVAAGVAAVLDRGTGADLQR 364 Query: 350 DFVADGGSLIGLVKKHCEIW 369 A G L +V+ E Sbjct: 365 RVFAATGDLTAVVRAAVEAT 384 >UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32130 Length = 382 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 103/351 (29%), Positives = 160/351 (45%), Gaps = 9/351 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F +PF+LG+E E+ +V+P + S+ +ID + G V+ ++ +EL TDV Sbjct: 15 FGEGDPFSLGVEEELFLVDPVTGEQINASTAVIDRL--GPVDGRVERELHACQVELITDV 72 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 CR +A G ++ V+ + + G GTHP + E+ D RY+R E G Sbjct: 73 CRTAGEAVGTLGGLRAAVVAT----GVGLLGAGTHPAAEEGDAEITDKVRYERIRELLGD 128 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + V G HVHVG + AI +GL R +P AL A SP+ DT AS+R Sbjct: 129 AVATP-VNGLHVHVGMPDAETAIRAFNGLRRHLPLLQALGANSPFRHSRDTGLASAREVT 187 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 +P +G + +++ F A+ L+ + W +RP P GTVE+R +DT Sbjct: 188 TRGWPRSGVPRAMRDFEDFCAMSALLARAADVPDYTWFWWKLRPHPRLGTVEIRALDTQT 247 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +L + L+ A + L F+A RYG++ + D G R Sbjct: 248 SLEDLAALVALVHCLARHASELGADPAADPPGELLDEGVFRAARYGIDAQLPD-AEGRLR 306 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 P+ ++E +AP A ++G ++ LHR V G A R A GG Sbjct: 307 PVRSLLDDVVEMVAPDARELGCEGELDGLHRLVERGG-GAGRQRSLHAIGG 356 >UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B5549F Length = 381 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 90/344 (26%), Positives = 147/344 (42%), Gaps = 7/344 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV---KHDITESMLEL 61 S P TLG E E +V+ + ++D G V + ++ SM+E Sbjct: 14 PAAHSAPPTLGAEEEFLLVDAETLVPVDAAERVLDVHHRLHPKGAVTVPQRELLSSMIET 73 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 + VC + + + SA ++ +++AA + GT Q R + Y+ Sbjct: 74 TSPVCAGLPELRAEVSAARERLVEAAAKAGCRVLAHGTAARQAPPRTP-TEAPHYRDVAG 132 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 + L Q G H+HVG + A++ L + ++P +ALSA SPY G DT FAS Sbjct: 133 LYRLLAQGTETCGCHIHVGVPDREAAVHALDHVRPWLPVLLALSANSPYEHGVDTGFASW 192 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMI-DSIKDLHWDIRPSPHFGTVEVRV 240 R + S +P P+ ++ ++A R L T ++ + ++ +W RPS H T+EVRV Sbjct: 193 RTMVLSRWPTTQIPPYFTDAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEVRV 252 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITD 298 D T+ AGL +A L ER + + A RYGL G + Sbjct: 253 ADVMPTVREVAAQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSLVH 312 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGL 342 P +G P E LL + + +G + A+ R ++ Sbjct: 313 PGSGTAVPAGEAVAALLAHVGEALADLGDEEEVTAVVRDLLHRG 356 >UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthrobacter RepID=CAAL3_ARTAT Length = 424 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 78/344 (22%), Positives = 133/344 (38%), Gaps = 6/344 (1%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G+E E+ +V+P + + + H++ +E T C + Sbjct: 31 TFGVEEELLIVDPVTGE--PLALADALLAGQDEPTSGLSHELKLEQIETQTRPCHSYGEL 88 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 Q + + QAA H + T P + RY L+ FG + + Sbjct: 89 LQQIRRGRAMANQAARQHGARVAAIATSPLA--SNTHTTPDPRYAAMLDRFGIIATEQLT 146 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVH S ++ + +L + + AL+A SPY +G T F S R ++ +P + Sbjct: 147 CGFHVHTSVESPEEGVVVLDHIRDKLAVLTALTANSPYWRGLPTGFDSYRTQAWNRWPTS 206 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 GP + + + + L T +I +++D R S + TVEVRV D L A Sbjct: 207 GPSSVFGSLTAYRRIVKRLLETGVIMDEGMIYFDARISRNHPTVEVRVADVCLRAEDAAL 266 Query: 253 MAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 MA L++A E + L + +QA GL G + D +P + Sbjct: 267 MAVLVRALVETASLEMLDGVEPTAVPTALLRMASWQASNSGLRGDLLDFGDFLPQPAADV 326 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD 354 L++ ++P G ++A V+ N A R+ Sbjct: 327 VWALVDYLSPVLDDQGELELVKAGISDVLDRGNGAHEQRETAVR 370 >UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0LDX8_GORB4 Length = 374 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 93/347 (26%), Positives = 153/347 (44%), Gaps = 5/347 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 T+G+E E +V+P + + A + +++ ++T +E AT + Sbjct: 15 APTVGVEEEFILVDPATEHPVARNGEVAAAASRR--GVDLELELTSCQVETATAPHHAVA 72 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + + ++ VV AA + + + G P + D RY+R E FG L + Sbjct: 73 DLLDELTRLRSVVAAAAAEVGVGVIAAGAPPTV-PVAFPITDTARYRRIGERFGMLAHEQ 131 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV + AI + + L +P +ALSA SP + DT AS R ++S +P Sbjct: 132 GVCGCHVHVAVPDRETAIEVSNHLRHRLPVLLALSANSPVYRDADTGHASWRWVLWSRWP 191 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP P + + + FE+L + I ++WD+RPS H T+EVRV D T S A Sbjct: 192 AAGPPPHLRSREHFESLVTMFVASGAILDDHMVYWDVRPSDHLPTIEVRVGDVQPTASEA 251 Query: 251 VNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 A +++ L + E D + ++A G++G D TG+ P Sbjct: 252 AAFAAIVRGLTLTALRDIDAGIAAPEIDTAILDAAMWKAAHDGIDGAGIDVLTGESVPAL 311 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + RL++ I+ + G + + A R + S N A R DG Sbjct: 312 DLVGRLVDDISDALDAAGDADLVTAARRSLGSRGNGATRRRRDFRDG 358 >UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WJM5_ACTMD Length = 383 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 91/345 (26%), Positives = 141/345 (40%), Gaps = 9/345 (2%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G+E E +V+P + + ++ AV++ + ++ S +E AT VCR + Sbjct: 5 TFGVEEEYLLVSPETSLPTASAPEVLAAVRDLPPGAMAQPELLSSQVEFATGVCRTAPEL 64 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 Q A + V AA + G P R V RY+ + L+ Sbjct: 65 REQLRAGRSAVADAAGRVGVLPVAVGNPPL--PGRVPVTRGSRYREITSLYQGLMTDYQC 122 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + +L L ++P +ALS SP+ +G DT + S R S+FP Sbjct: 123 CGCHVHVGVPDRATGVAVLDHLRPWLPTLLALSVNSPFDRGEDTGYGSWRAVRQSSFPGW 182 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G P + ++ + L T ++ W R SP + TVEVR DT T+ AV Sbjct: 183 GVPPLLRTVERHDRLVEAAVDTGVLVDPTMTFWLARLSPKYPTVEVRAADTAATVDGAVL 242 Query: 253 MAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 A L +A L ER + + + + + A R+G G DP TG + Sbjct: 243 QAVLTRALVDTALAALERGEEAPDHEPAVLTAALWSAARHGTAGQGVDPTTGRAVRAEDL 302 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 LL + P+ + + L + G + A L R DG Sbjct: 303 ARALLAHVRPALDA--DAGWVADLA---LRGRSGAALQRAAGDDG 342 >UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=Persephonella marina EX-H1 RepID=C0QT87_PERMH Length = 362 Score = 336 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 168/359 (46%), Gaps = 9/359 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF S+PFT+GIELE+Q+V+ ++LS+ S ++ + + ++ SM+E+ T Sbjct: 4 DFRSSKPFTVGIELEIQLVDRGSFELSESSEIVFSNASEGLKK-LLHPELLTSMVEIVTP 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 VC +A K + D+ GTH F K + + +RY + LE F Sbjct: 63 VCETPEEAVSHIKNAVKEIDLIGEDYGFRSAALGTHVFAKKETIHITAKDRYLKLLEEFQ 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 L++Q ++G H+HVG + AI + +P F+A+S +SP+ G T S R Sbjct: 123 ILLKQFLIYGLHIHVGFPEKEMAIKAYNETLNNLPLFLAVSTSSPFFLGEFTGLNSFRTK 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 IF P G + ++ FE L+ L I SIKD+ WD+R P FGTVE+RV D+ Sbjct: 183 IFEQLPRAGIPEYFDSYSDFEKLYFTLLENGFIQSIKDIWWDVRIHPDFGTVELRVCDSN 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + +A L QA + ++ + + K N++ A RY +EG + Sbjct: 243 PDMERIEFIATLFQAVCFYSSFSSGERYF---HQILKQNKWNATRYSVEGRFL--YREGT 297 Query: 305 RPLTEDTLRLLEKIA--PSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 + + +++++ ++G +E L + + +Q+M + GS+ L Sbjct: 298 VQIKKRIADIIKELKKTDILKELGTEKRMEKLSDIIGKK-SISQMMIEEYRKKGSIKEL 355 >UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actinomycetales RepID=CAAL2_NOCSJ Length = 369 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 89/367 (24%), Positives = 147/367 (40%), Gaps = 10/367 (2%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKN------KITAGEVKHDITESMLELATDVC 66 T+G+E E +V+ +S + ++ AG + H++ E LE+ T Sbjct: 3 TVGVEEEFLLVDADRSRPIPAASRALRVATEWGVAGGQVGAGALVHELQEQQLEIYTAPQ 62 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 + + A + AA + T P + RY R E FG + Sbjct: 63 VRMASLETELRAWRAAAAAAAAAVGARLVASATSPVA--VEPHRVRSPRYDRMAERFGIV 120 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + G HVHV S +A+ +L + ++P +ALSA SP+ QG DT +AS R Sbjct: 121 TDEQLTCGCHVHVAVGSTAEAVGVLDRIRVWLPALLALSANSPFWQGRDTGYASFRIQAL 180 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P +GP ++ L + ++ L++D R S F TVE+RV D L Sbjct: 181 GRWPLSGPTELFGTAAAYQELVERVLAAQVVLDQGMLYFDARASHRFPTVEIRVADVCLD 240 Query: 247 LSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + V +A L +A + +L + + A R+G+ + DP T Sbjct: 241 VRDTVLIAALCRALVETSAARWAAGEAPPQVPAVLLRLATWHASRWGVSADLLDPMTARP 300 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P E RL+E P+ + G + +++ N A RD A G L +V Sbjct: 301 LPAAEVVGRLVEHARPALRRSGDDGLVADGIARILEHGNGATWQRDVFAGSGRLDEVVSA 360 Query: 365 HCEIWAG 371 + +G Sbjct: 361 LALVTSG 367 >UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax=Streptomyces RepID=C9YX80_STRSW Length = 375 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 147/336 (43%), Gaps = 4/336 (1%) Query: 40 AVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 A+ ++ E K ++ S +E + V + + ++ + AA+ L + GT Sbjct: 6 AILGRLGGPEFKAELQRSAVEWNSPVHASLESLHTDLTGARRRLAAAASGLGLSVVAAGT 65 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 P + + + RY+ E + + + V VHV D A+ ++ +S ++P Sbjct: 66 VPLARLTPGDTTPDFRYRYMTEEYRRVADEHLVCSAQVHVDVPDRDTAVRIMCAVSPWLP 125 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 +AL+A+SP+ G DT +AS R ++ +P GP+ + +++A + L + +I Sbjct: 126 PLLALTASSPFWLGADTGYASWRTMLWQRWPTAGPVGCFAGAAEYDAAVQGLIRSGVIKD 185 Query: 220 IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATA---HWLLTERPFKHQEKD 276 +++D+RPS H T+E+R+ D V + GL +A LL P + E Sbjct: 186 SGMVYYDLRPSEHQRTLELRICDASPRPETVVLVTGLFRALVEDARGLLEREPERVCEGG 245 Query: 277 YLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHR 336 + + ++A R GLEG + DP T P +L ++ P+ G + L Sbjct: 246 HEWLRSAVWRAARSGLEGDLVDPVTRGAAPAPAVLRGMLRRLRPALEAAGDWDTVPVLLE 305 Query: 337 QVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 + ++ + A +R + G L V G+ Sbjct: 306 EALARGSAAHRLRRVAGERG-LPACVGTLVAETRGE 340 >UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseudomonas RepID=CAAL_PSEE4 Length = 380 Score = 331 bits (848), Expect = 4e-89, Method: Composition-based stats. Identities = 75/347 (21%), Positives = 145/347 (41%), Gaps = 4/347 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 ++ P+T GIE E + + + S + ++ ++ S +E+ + V Sbjct: 1 MARPWTFGIEEEYLLADTTSGQVLASPSPAVTRRCREMLGATFAEEMFLSQIEVVSPVFD 60 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 ++QA ++ + +A D + + G +HP +W RQ +++ +++ + Sbjct: 61 SLHQARSFLGENRQRLGEALGDFGVGLYGAASHPCAQWLRQHPRGTAHFRQLFDDYRLVA 120 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +++ V G HVHVG +G D + L++ + ++P F+ LS +SP G DT + S R I Sbjct: 121 RRSLVNGLHVHVGVPAGTDRMQLINRVLYWLPLFLVLSTSSPLWGGQDTGYMSYRRVICG 180 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P G +++W ++ L T + D W IRPS F TVE+R+ D L Sbjct: 181 EWPHMGLPEPLADWHAYQRYRGLLQRTGALAEDGDFWWAIRPSRRFPTVELRICDGCPRL 240 Query: 248 SHAVNMAGLIQATAHWLLTER-PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + +AGL + L + + + N ++A RYG G Sbjct: 241 EDGLAIAGLYRHLVQHALARHDGMAVSREIRWITQENYWRAARYGRRGTFIGAVDQQPVS 300 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA 353 +L + + + + R+++ A R+ A Sbjct: 301 AEGWLAQLQSWLPADSAE---AERSFMQARRILREGTSADRQREAYA 344 >UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GGR3_9ACTO Length = 377 Score = 329 bits (843), Expect = 2e-88, Method: Composition-based stats. Identities = 89/324 (27%), Positives = 141/324 (43%), Gaps = 7/324 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV---KHDITESMLEL 61 P TLG+E E +V+ + ++D G V + ++ SM+E Sbjct: 41 PADPGAPPTLGVEEEFLLVDAETLLPVDAAERVLDVHHRLHPQGAVTAPQRELLSSMIET 100 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 + VC D+ + SA ++ +++AA + GT Q R + Y+ Sbjct: 101 TSPVCADLPGLRAEVSAARERLVEAAGKAGCRVLAHGTAGRQAPPRTP-TEAPHYRDVAG 159 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 + L + G HVHVG + A++ L L ++P +ALSA SPY G DT FAS Sbjct: 160 LYQLLARGTETCGCHVHVGVPDREAAVHALDHLRPWLPVLLALSANSPYEHGADTGFASW 219 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMI-DSIKDLHWDIRPSPHFGTVEVRV 240 R + S +P P+ ++ ++A R L T ++ + ++ +W RPS H T+EVRV Sbjct: 220 RTMVLSRWPTTQIPPFFADAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEVRV 279 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITD 298 D T+ + AGL +A L ER + + A RYGL G + Sbjct: 280 ADVMPTVREVASQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSLVH 339 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSA 322 P +G P E LL + P+ Sbjct: 340 PLSGVAVPAREAPAALLVDLGPAL 363 >UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseudomonas mendocina ymp RepID=CAAL_PSEMY Length = 378 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 79/346 (22%), Positives = 145/346 (41%), Gaps = 4/346 (1%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 T GIE E + + +++ + V ++ + E+ T V + Sbjct: 2 TQSTFGIEEEYFLTDLTSRQVARRNVEAFATACQYELGERVTREMFAAQFEVVTPVLHSL 61 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 A ++ + + A + + GTHP +W+R D RY+ +++ + + Sbjct: 62 TDARQCLEGARRALARLAREFDCGVLAAGTHPLGQWRRVRATDMPRYRAIFDDYRMVASR 121 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + + G HVHVG A G D I L++ L+ ++P + LSA+SP+ G + S R + + Sbjct: 122 SVLAGLHVHVGVAEGVDRIRLMNRLTPWLPLLLGLSASSPFWNGRPSGLMSYRQAVCDEW 181 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G ++ +++ + ++ T I S +L W+IRPS + T+E+R+ D L Sbjct: 182 PRMGIPDHFADEAEYQRYVQVMTDTGCIRSAANLWWNIRPSLRYPTLELRIADACPRLDD 241 Query: 250 AVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 A+ +AGL +A L + +L NR++A R GL G+ +P + Sbjct: 242 ALCLAGLFRAMVEHVQLTPHHAWCDDPLTRVLTLENRWRAKRQGLRGLFIEPASQRLLTF 301 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA 353 +LE+IA I R + A+ Sbjct: 302 ATWLEEVLERIAIQVPASD--RWILEHARNLALHGGSAEAQLAEYR 345 >UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Halobacteriaceae RepID=CAAL_HALWD Length = 363 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 91/358 (25%), Positives = 152/358 (42%), Gaps = 17/358 (4%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAV--KNKITAGEVKHDITESMLELATDVCRDIN 70 TLG+E E VV+ G + ++ D + A + H++ + ++E T + D++ Sbjct: 14 TLGVEEEFFVVDDSGQPTAGIQELIYDYNHPPAGVLADRLDHELFQFVIETQTPLLEDVS 73 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + A++ ++ A DH I G HP KW+ + + RYQ L+ Y + Sbjct: 74 AVSESVQAVRDALVTHAADHGYRIAAAGLHPTAKWRERNHVEKPRYQSQLDRIQYPQHRN 133 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 T G HVHVG D A ++ + L ++P +ALSA SPY G DT AS+R IF A P Sbjct: 134 TTAGLHVHVGVDDPDAATWIANELRWYLPPLLALSANSPYWNGFDTGLASARAKIFEALP 193 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 + G +++ + L + + T I +L +D+RP GTVEVR D S Sbjct: 194 NTGMPTRFEDFEAYYQLEKRMVETGSIKDRGELWYDVRPHTGHGTVEVRTPDAQADPSVT 253 Query: 251 VNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 V + I A + + N++ A RYG + P + + L+ Sbjct: 254 VAIVEYIHALVMDFAARYADGESGTKVRREILDANKWHAMRYGRDAEFIIPGSMETVTLS 313 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHC 366 E R ++ ++ L + A+ R A ++ L++ C Sbjct: 314 EFVDRETNRLG-----------VDGLTTLLAREG-GAKKQRRLHASD-NIDTLLESLC 358 >UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Streptomyces RepID=CAAL_STRCO Length = 363 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 85/361 (23%), Positives = 154/361 (42%), Gaps = 5/361 (1%) Query: 13 TLGIELEMQVVNPPGYDLSQ-DSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T+G+E E+ +V+P + +++L A + + ++ E MLE AT D+ + Sbjct: 3 TVGVEEELLLVDPATGEPRALSAAVLARAFLDDSEQDVFEKELHEQMLEFATHPQADMER 62 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++ + A + T P + N RY+ E +G ++ + Sbjct: 63 LHAEIVRCREEAGRHAGGIGCAVAALATSPL--PVTPSIGVNRRYEWMAEQYGVVVHEQL 120 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHV S ++ + ++ + ++P ALSA SP+ QG D+ ++S R ++ +P Sbjct: 121 VLGCHVHVSVDSDEEGVAVIDRVRPWLPVLAALSANSPFWQGRDSSYSSYRSRVWQRWPS 180 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP + +++ + T + +++D+R S + TVE RV D L S AV Sbjct: 181 AGPTELFGSAERYHRRVADMLATGTVLDDGMVYFDVRLSQRYPTVEFRVADVCLDASTAV 240 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A L +A E + E L + ++A R GL + P T R P Sbjct: 241 VLAALARALVDTAAREWRAGAEPAEHSVSLLRLAAWRAARSGLTSELLHPATMRRMPAES 300 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIW 369 LLE + G + +++ N A++ R+ +A GSL +V Sbjct: 301 VVRDLLEHAGEALAAAGDLERVREGVEKLLRHGNGARVQRELLARTGSLREVVAACVRRT 360 Query: 370 A 370 Sbjct: 361 Q 361 >UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32412 Length = 381 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 98/370 (26%), Positives = 153/370 (41%), Gaps = 12/370 (3%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKI-TAGEVKHDITESMLELAT 63 F S FT+G+E E V++P L+ L DA + A + ++ S +E+ + Sbjct: 11 AFEDSTDFTVGLEEEFAVLDPGTRALTPRFEELRDAAQADPVLAESIAGELISSEIEIRS 70 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 D+ AA + ++ + A + + + GTHPF ++ Q + D E Y R + Sbjct: 71 GKGVDVADAAIRQRDHRRRLFALAQERGIALGATGTHPFSDYREQRIIDTEHYHRVEDGL 130 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 Y+ + F HVHVG D A+ + L +P +A+SA SPY+ G D+ + R Sbjct: 131 KYVAWRNNTFSLHVHVGVQGADRAVQVCDRLRPVLPLLLAISANSPYVDGRDSGLHTVRT 190 Query: 184 NIF-SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 F +FP G +WQ F + L T I + W +RP FGTVEVR+ D Sbjct: 191 QTFTKSFPRCGVPDAFGSWQAFRSYLEFLVATNSIVEYTQVWWSVRPHLSFGTVEVRICD 250 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 T + +A LI A + + L + N ++A R GL+G + D Sbjct: 251 AQSTAGESDGLAALIVACVAQAARDVEDGVPFADPPARLIEENMWRAIRRGLDGPLIDLE 310 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P RLL AP ++G A+ L N AQ R + G + Sbjct: 311 RAVEFPGQAALERLLAWTAPVRAELGIDVALPEL--------NGAQRQRRMIDAGAGIEE 362 Query: 361 LVKKHCEIWA 370 + Sbjct: 363 VYAATVRETR 372 >UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyces RepID=B4V111_9ACTO Length = 391 Score = 321 bits (822), Expect = 4e-86, Method: Composition-based stats. Identities = 93/364 (25%), Positives = 147/364 (40%), Gaps = 8/364 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+ + +I+A V+ + M+E+ T Sbjct: 27 PTLGVEEEFLLVDRLTRAPVPRAGPVIEAASY-FLGDLVQEEFYRCMVEVCTRPATTATD 85 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 Q + +++ QAA + GT V D RY+R FG L+ Sbjct: 86 VRAQLALLREAAAQAARASDCLLVASGTAVVPPDAPIPVTDTPRYRRMARQFGALVDGNL 145 Query: 132 --VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG A A++L + + ++P AL+ SP+ G DT FAS R F + Sbjct: 146 GIVCGCHVHVGAADRAQALFLANHVRPWLPALQALAVNSPFAGGVDTGFASWRCVEFGRW 205 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P P P + + +E L + ++ + ++W RPS H TVE RV DT L Sbjct: 206 PTAEPSPLLDSAS-YEESASALVDSGILMDRRMIYWFARPSEHHPTVEFRVADTNADLDT 264 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLL--YKFNRFQACRYGLEGVITDPHTGDRRPL 307 V +A L++ LL + + D + + A +YG G+ DP TG+R P Sbjct: 265 TVLVALLLRGLCATLLAQAEERRPPPDAPVPRLRDAHRYAAQYGPTGLALDPFTGERVPA 324 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG--SLIGLVKKH 365 L+ AP G + + L ++ A R + G L +V Sbjct: 325 RSLITALVAAAAPGLRAAGDEAEVHRLLGALLRKGTGAARQRAALHRSGGRGLRAVVDHL 384 Query: 366 CEIW 369 ++ Sbjct: 385 ADLT 388 >UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL3_RUBXD Length = 384 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 92/374 (24%), Positives = 153/374 (40%), Gaps = 14/374 (3%) Query: 1 MPLPDFHVSEP-FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESML 59 +P F P TLG E E+ + +P L+ + ++ A A ++ + + Sbjct: 15 LPEEAFETGAPEGTLGAEEELWLADPETLKLAGGAQKILAA----EPAEHFSGELIDCEV 70 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E T V R+ A A ++ +L+ A + GTHP W+ QE+ D YQ Sbjct: 71 EANTGVHREAAGVARDLLARRRTLLEHAGRLGRVLGTSGTHPLGDWREQEIIDKPHYQYL 130 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 G+LI++ F HVH + IYL + +VPHF+A+S SP+ QG T Sbjct: 131 KRKLGWLIRRNNTFSLHVHYAVQGKEKVIYLFDRIREYVPHFLAVSVNSPFWQGEFTDTR 190 Query: 180 SSRPNIFSA-FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 S+R +FS P G +W + + +I + ++ WDIRP P T+E+ Sbjct: 191 SARALVFSRSLPHAGMPEAFGSWSAYAGYLDFVGRPGVIRRLGEIWWDIRPHPRLSTLEI 250 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 R D + + + L AT L E + + N++ A R+GL+G+ Sbjct: 251 RAFDAQTDPARSEALISLAAATCDMLCAEYESGELRPARPVREIEDNKWSAQRHGLDGLF 310 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 D T + P RL E A S S + +++ E++ + G Sbjct: 311 VDHETHEPVPARWAVERLAELAASS------SRRDLSSLERLLEEPTESERQLLVWRETG 364 Query: 357 SLIGLVKKHCEIWA 370 S+ + + Sbjct: 365 SVKEVARDIARRTR 378 >UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocardioides sp. JS614 RepID=CAAL1_NOCSJ Length = 382 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 82/367 (22%), Positives = 147/367 (40%), Gaps = 12/367 (3%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA--------GEVKHDITESMLELATDV 65 LGIE E+ + +P ++ + ++ + E+ ++ LE TD Sbjct: 5 LGIEEELLLFDPESGEVVPAAPSVLKEFREHGPGRQRARAATDELDQELFRHQLETRTDP 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 R A Q A ++ +AA G P R V N+RY+ ++ +G Sbjct: 65 VRRAADALDQLVAARRTAGEAARAAGYAAGACGIVPLGG-DRSVVSPNDRYRDMVDTYGE 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + + G HVHV S ++ + ++ ++ ++P +AL+A SPY++G D+ +AS R + Sbjct: 124 IARTGGTCGMHVHVDIGSDEEGVAVVDRIAPWLPVLVALAANSPYVEGRDSGYASWRAQV 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 ++ +P GP + + + R L L++D R S TVEVRV D Sbjct: 184 WARWPSAGPTEQFGSVAGYREVCRMLLDVGAARDPGMLYFDARLSTGQPTVEVRVCDVGT 243 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVITDPHTGD 303 + AV + L++A E + + ++A R+G+ + P Sbjct: 244 DPAVAVTIGALVRALVETAAEEWADGRPAAHWRAEALRAAHWRASRFGMADSLVHPLARG 303 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 RP L+E + P+ G ++ + V N A R GS+ G+V Sbjct: 304 LRPARSVVAALVEAVEPALAAAGDLELVDVQLERAV-NDNGATRQRAAFERTGSVRGVVD 362 Query: 364 KHCEIWA 370 Sbjct: 363 DVIARTE 369 >UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphaproteobacteria RepID=B1M5M5_METRJ Length = 388 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 74/369 (20%), Positives = 138/369 (37%), Gaps = 10/369 (2%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 + GIE E + + + A + + + + +E+A+ D+ Sbjct: 4 AYRFGIEEEFFLADARTRGTPRAGLRAFHAAVRGRL-DDAEREQLQCQVEVASPPTADLA 62 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A + ++ + + + + GTHP +W+ Q D RY + + L ++ Sbjct: 63 EARAHLADLRASLAEIGGERGILTFAAGTHPTARWRDQRPTDKARYHGIMADLRMLGRRN 122 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV I L++ L ++P +ALS SP+ QG T A R ++ P Sbjct: 123 LVCGLHVHVEVPDPAARIGLINRLLPYLPVLLALSTGSPFWQGQQTGLAGYRMRAYAELP 182 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G ++ + ++ + I L W +R S + T+E+R+ D+ L A Sbjct: 183 RTGVPELFADADDYARYVDVMTRSGAIADASYLWWHVRASVKYPTLELRIADSCARLDDA 242 Query: 251 VNMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A L + ++ +R N ++A G+ + D P+ Sbjct: 243 LCIAALFRCLVRRVVRDRRLNAGLTAASRGFVLENLWRAECDGVRATLIDEARVRAVPVA 302 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-------MRDFVADGGSLIGL 361 LL IA A +G +A R V G + + R + +L + Sbjct: 303 AAVEALLADIAEDADALGCGAACAHASRIVAEGTSADRQMAVFAAARRSGARERAALSAV 362 Query: 362 VKKHCEIWA 370 V A Sbjct: 363 VDHLAAETA 371 >UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Corynebacterium lipophiloflavum DSM 44291 RepID=C0XRA9_9CORY Length = 854 Score = 319 bits (817), Expect = 2e-85, Method: Composition-based stats. Identities = 79/357 (22%), Positives = 148/357 (41%), Gaps = 7/357 (1%) Query: 18 LEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFS 77 E+Q+V+ L+ + +L+ ++ A +++ SM+++A+ D+ + Sbjct: 5 EELQLVDKETRRLAPKADVLLSQLEGDAFAPSIQN----SMIQVASGSHGDVTSLRDELL 60 Query: 78 AMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHV 137 + A L I GT P + RY ++ L ++ + + Sbjct: 61 QGRARASSVAEPLGLAIAAAGTMPLAHRASLAITPRSRYMEMSADYALLAREQLICSAQI 120 Query: 138 HVGCASGDDAIYLLHGLSRFVPHFIALSAASPY-MQGTDTRFASSRPNIFSAFPDNGPMP 196 HV D A+ + G+SR +P +ALSA+SP+ ++G+DT +ASSR +P +GP Sbjct: 121 HVEVRDRDQAVAVSPGVSRHLPLLLALSASSPFSVEGSDTGYASSRDLTGQRWPTSGPFA 180 Query: 197 WVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGL 256 VSN ++++ L L +I +++ + PS +E+RV D+ ++ +A L Sbjct: 181 PVSNAKEYDELVDTLIKAGVIADEAMMYYSLAPSVSKPLLELRVCDSCPSVDAISTIAAL 240 Query: 257 IQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRL 314 +A L + + L++ ++A R GLEG + P T RP E Sbjct: 241 FRAMVVREAALVDASTPTPPLNPTLHRSMMWRASRSGLEGSLICPETYTPRPAAEVLRST 300 Query: 315 LEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 +E + G + ++ A R G L +V + G Sbjct: 301 VELLTDELRASGDLEMVTRFVEGIIRTGTSAYRQRRAYRSRGRLDDVVDQLMSETVG 357 >UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GH73_KOCRD Length = 378 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 83/351 (23%), Positives = 136/351 (38%), Gaps = 3/351 (0%) Query: 7 HVSEPFTLGIELEMQVVNPPGY-DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 S T GIE E +++ V + G + +E + + Sbjct: 12 GGSTMSTFGIEEEFLLIDRGDRLPARPTPEQSAQLVSLEAGGGSATPEWLACQVEETSPI 71 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 D A + + A +++ G P + + ++ NERYQR Sbjct: 72 FHDAAGAVDSLVTFRTALHDATDAMGMDVVGLAAAPDIRPEPADITVNERYQRLAGYTPA 131 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + + G HVH+G +DA+ L+GL ++P +A+ A SP +G ++ F S R Sbjct: 132 VAADQYISGMHVHLGFPDMEDAVRALNGLRGWLPALVAIGANSPLWRGAESGFESWRSIH 191 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 + + N P + E LS +++S L W R S GT+E+R D L Sbjct: 192 YRRWIANDIPPHFKDLADHEQRVAVLSAFDVMESPSTLSWLARLSHKHGTLEIRACDVQL 251 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +V +A LI+A A + + P ++Y +QA R+GL G + DP + Sbjct: 252 EAQDSVAIAVLIRALADYAMDVPPTMEFSQEY--LDIALWQAARWGLSGRVLDPVAAELV 309 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 P LLE++ EA R++ N A R A G Sbjct: 310 PGEALVTDLLERVRDYYPTAADREFAEAGVRRIAERGNGAIRQRRAFARAG 360 >UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobacteriaceae RepID=C7NRF5_HALUD Length = 365 Score = 312 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 86/345 (24%), Positives = 148/345 (42%), Gaps = 14/345 (4%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 TLGIE E VV+ G +S +++ ++ I + H++ + ++E T V D A Sbjct: 14 TLGIEEEFFVVDEYGRPVSGTDTLVYNSEPPAILENRLDHELFKFVIESQTPVIEDPGDA 73 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 A SA++ +++ A DH EI G HP +W+ E + RY+ L+ Y + T Sbjct: 74 AATLSAVRGALVEHARDHGFEIAAAGLHPGARWRELEHAEKPRYRSQLDRIQYPQHRNTT 133 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + A+++ + + +P +AL+A SPY G DT +S+R +F P+ Sbjct: 134 AGLHVHVGVDDAEKAVWIANKIRWHLPIVLALAANSPYWNGFDTGLSSARAKLFEGLPNT 193 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G +++ F + + T I +L +D+RP +GTVEVR D + + Sbjct: 194 GMPTTFDSFESFHRFEQRMIETDSISDRGELWFDVRPHTEYGTVEVRTADAQADIDRVLA 253 Query: 253 MAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 + + L E L N+++A R+G E + Sbjct: 254 LVEYVHELVLDLAARYEDGETITAVRRELLDENKWRAIRHGREASFITRDGAETI----- 308 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 L+ I ++ + +L V+ + A R D Sbjct: 309 --DLMTAIERDRSRL-DLDRLASL----VAAESGATRQRRLAEDS 346 >UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frankineae RepID=CAAL2_FRAAA Length = 383 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 77/366 (21%), Positives = 146/366 (39%), Gaps = 17/366 (4%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKH-------------DITESML 59 T+G+E E +V+P + + +S ++ G ++T + Sbjct: 8 TVGVEEEFVLVDPDRHAVRAAASRVLARGDRDGAGGPPGGADPDGDLDGDLDVELTREQV 67 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E + + G +++ +AA + + T R + RY+R Sbjct: 68 ESGSAPHTSLAGLRGSLVGLRRAAARAAEAAGVALAATAT--CPTPTRPTITPKPRYERM 125 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 FG ++ G HVHV S +A+ L L ++ +A++A SP+ QG D+ +A Sbjct: 126 RGEFGLTAREQLTCGCHVHVAVHSRQEAVGALDRLRPWLSVLVAMTANSPFWQGADSGYA 185 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R ++ +P G + +++ + L T +++D+R S H+ T+E+R Sbjct: 186 SYRTQVWQRWPTAGATGAFGSPAEYDRVVDLLIRTGAAMDDGMIYFDVRLSHHYPTLELR 245 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 V D L++ +V +A L +A + L + ++A R+G+ G + Sbjct: 246 VADVCLSVDDSVLLAALARALVATAARQWAAGEPVPTVRPELLRAAGWRASRHGVSGELV 305 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 D G+ P R +E + P G A+ AL + + A R A G Sbjct: 306 DLERGELVPARALVDRFVEWVGPELSATGDGDAVAALVDNLFARGTGADRQRAAYARRGR 365 Query: 358 LIGLVK 363 + +V Sbjct: 366 IDDVVD 371 >UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYE4_CATAD Length = 372 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 81/365 (22%), Positives = 144/365 (39%), Gaps = 11/365 (3%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+ + ++ + ++ G + ++ ++ +E T + Sbjct: 12 LTLGLEEEFVLVDGREPVTVPRAEAVLARIGGRLD-GRMHRELFQTQIETNTLPRVTAAE 70 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + + ++AA + G + + V + RY F ++ + Sbjct: 71 LRADLAETRGAAIEAAAGLDTRLVASGAGVLSR-RPLPVTQSPRYLEIARRFPDVLAEFE 129 Query: 132 --VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 G H+H+G D A+ L L ++P +L+ SP+ G D AS R F + Sbjct: 130 SEPSGCHIHLGTLDRDRAVLLGTRLRPWMPLLQSLAGNSPFAAGRDRGCASWRYFEFQHW 189 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P GP P ++ +E R L + + K ++W RPS + T+E+RV D L+ Sbjct: 190 PSAGPAPSLTG-GGYERAVRRLMESGTVMDRKMIYWFTRPSERWPTLEIRVADVNPDLNV 248 Query: 250 AVNMAGLIQATAHWLL----TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 V +A L++ A +L ++P ++ L+ + A R+GL DP +G Sbjct: 249 PVLLALLVRGLAATILAALQADQPVPGTDEHRLI--EDHRLAARFGLAAEGLDPVSGTLA 306 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 E LLE P G L +V + A R GSL +V Sbjct: 307 SAEERAASLLEFSRPGLEPGGDLETAALLLAEVRATGGGAAQQRADFQVRGSLSDVVDGL 366 Query: 366 CEIWA 370 + A Sbjct: 367 VKRTA 371 >UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1BT73_XYLCX Length = 357 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 76/358 (21%), Positives = 137/358 (38%), Gaps = 8/358 (2%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E E+ ++ + + +++ G ++++ E LE AT+ R + + A Sbjct: 1 MGVEEELLLLG-HDGSPAPRAQEVLEGA--DAGDGPLENEFMEEQLETATEPARSLTELA 57 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 + +AA + T P RY R FG + Sbjct: 58 DALRTGRAGAREAAARQDALVAALATSPVAFTGT--TVSRLRYLRARSAFGITAWEQLTN 115 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 G HVHV A + + +L + ++ +ALSA SP+ QG T + S R +++ +P G Sbjct: 116 GCHVHVAVADDAEGVAVLDRIGPWLAPLLALSANSPFWQGGATGYESFRSQVWARWPTAG 175 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 P + + + L T + +++D R S + TVE+RV D L + AV + Sbjct: 176 PTRVFGSPEAYHEAVAALVATGTVLDEAMVYFDARLSARYPTVELRVADVCLDVDSAVLL 235 Query: 254 AGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 L + E + L + ++A GL+G + DP T P + Sbjct: 236 GALARGLVETAARAAEAGEPPPDAPPELLRTAHWRAGHSGLDGDLLDPATWRPAPAHDVV 295 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRD-FVADGGSLIGLVKKHCEI 368 L+ + + G + L + S N A R A G L + + + Sbjct: 296 GALVTHVKDALADAGDLDVVTELLGALWSRGNGAVRQRTWAAAADGDLHAVSLQAADA 353 >UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31B6A Length = 378 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 93/366 (25%), Positives = 162/366 (44%), Gaps = 10/366 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F + T+G+E E+ +++P L+ + L+ + K ++ + +E++T Sbjct: 19 FDATGGLTVGVEEELMLLDPATLALAPMAGELLQRLGGDT---RFKPELPAAQVEISTAA 75 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + A Q +A ++ + AA + G HPF + RY +G Sbjct: 76 AASVADAVAQLAAARRDLAAAAGGL-VLPAAAGVHPFSG-AEGALNRGGRYDVLQAEYGP 133 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++ V G VHV D + + + L ++P AL+A +P+ G D+ AS RP I Sbjct: 134 IARRQLVAGLQVHVAVGGADRTLAVYNALRAYLPELAALAANAPFHCGRDSGLASVRPTI 193 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 P G P + +W QF A R + + + W++RP FGT+E+RV D Sbjct: 194 SEQLPRQGVPPRLESWDQFAAELRWGALAGSVPEPRMWWWELRPHATFGTIELRVPDAQT 253 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQ--EKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 ++ A + QA L + + + NR+ A R+GL+G + D TG+ Sbjct: 254 SVGEAAGVIAFAQALVATLAERHDAREALLDAPTWRIEENRWSALRHGLDGTLADLVTGE 313 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 R P + L+ +AP A ++G + A+ A +V N A R+ D G + GLV+ Sbjct: 314 RVPTRDRLGELVAAVAPEAERLGCADALTATRAAIV--ANGAVRQREVARDRG-VDGLVR 370 Query: 364 KHCEIW 369 E + Sbjct: 371 WLTERF 376 >UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYG9_CATAD Length = 373 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 82/370 (22%), Positives = 147/370 (39%), Gaps = 7/370 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L D E T+G+E E +V+P + + ++ +V ++ + +E Sbjct: 1 MTLKDSRDLELLTVGVEEEFMLVDPVSRFTVPRAPEVHAFAAERL-GEQVARELYATQVE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + + + ++ + AA + GT + + + ERY+ Sbjct: 60 INSRPAKQAEVLRQDLVEARRALASAAAHFDCMLVASGTAVLTT-KPFPITEGERYEEIA 118 Query: 121 ENFGYLIQQ--ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 E + + G HVHVG D+A+ L L ++P L+ SP+ G+ R Sbjct: 119 ERYSAATTDIDSEASGCHVHVGDLECDEALALAGHLRPWLPVLQVLAVNSPFAAGSFRRV 178 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS R A+P GP P ++ ++EA + L ++ + ++W RPS H T+E+ Sbjct: 179 ASWRHYQQQAWPITGPTPMMTAL-EYEARAQELVDAGVLIDKRMIYWYARPSEHQPTLEI 237 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 RV D + + +A L +A A LL + + L + + A G G+ Sbjct: 238 RVADVCADVDITLLVAVLTRALAMVLLADVRADTPAPRTEELEVREHHRGAATLGPAGLW 297 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 T P +G PL+ L+ P+ + + + L R+ AQ R G Sbjct: 298 THPLSGVSMPLSAGVEALVAHARPALEMLDETRLVAQLLRRAYHRGTGAQRQRAAYRRRG 357 Query: 357 SLIGLVKKHC 366 L +V + Sbjct: 358 RLEDVVDELA 367 >UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudomonas fluorescens Pf-5 RepID=CAAL_PSEF5 Length = 387 Score = 286 bits (732), Expect = 9e-76, Method: Composition-based stats. Identities = 77/370 (20%), Positives = 142/370 (38%), Gaps = 10/370 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 F +P LGIE E + + + + + + +++ + +E+A+ Sbjct: 3 AFDPGQPQHLGIEEEYLLTDLQSRCMVAEPPPEVLRDCREALGQNFAYEMFQGQIEVASP 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V QA ++ + QA H L G+HP W Q +++ F Sbjct: 63 VFDHSAQAGAYLRQVRSALDQALASHGLGFICAGSHPLADWHEQRATPQAHFRQLFNEFA 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 +++ + G HVH + D I +++ + + P +ALS +SP+ QG D+ + S R Sbjct: 123 LAARRSVLSGLHVHAQVPAAVDRIAVMNEVLPWTPLLLALSLSSPFWQGHDSGYLSYRQV 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +P G ++ + Q F+ R L + + + W IRP+ + T+E+R+ D Sbjct: 183 ACDEWPRMGIPEYLHDHQAFDDYLRLLRGIGALGAEDNAWWGIRPALRYPTLELRMTDAC 242 Query: 245 LTLSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 ++ A +AGL LL ++ + L K NR QA R G +G Sbjct: 243 PRVADAQTLAGLFAVMVRHACLLPAAGSQYTQAQRWLLKENRVQARRRGAQGRYLMSPDQ 302 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA-------DG 355 L + + +A +G + RQ++ G A+ A Sbjct: 303 APMNLGQWLELAEQVFGDTAQALGE-EPLFERARQLLRGGCSAERQLSCHAAQPAESDRE 361 Query: 356 GSLIGLVKKH 365 +V Sbjct: 362 ARCRAVVDLL 371 >UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylobacterium RepID=B0UDI3_METS4 Length = 377 Score = 283 bits (725), Expect = 7e-75, Method: Composition-based stats. Identities = 70/349 (20%), Positives = 134/349 (38%), Gaps = 5/349 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 ++ F L IE ++ + + D ++ V + +HD+ E L +T Sbjct: 1 MAADFALCIEEDVFLNDAQKRDAARARMRDFLGVCRRDF-PAARHDLIEPRLIWSTPPVA 59 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D+ +A A++ + A L + GTHP W R D R + + Sbjct: 60 DLAEARRALEALRGGIGALAAARGLTVMAAGTHPIALWSRVRPRDAAARDRVQRDLQMVG 119 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + V G + VG G I +++ + F+P +ALS +SP+ Q T R Sbjct: 120 SRTVVCGLSIRVGLPEGVSRIDVMNRIQPFLPLILALSTSSPFWQAQRTGLMGYRLAASR 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 P +G P+ + L I + + W IRP+ +++R+ D+ L Sbjct: 180 ELPRSGLPPYFRDEDDHARYLAALMRAGAIADLAHVWWVIRPAGEAHALDLRIADSCTRL 239 Query: 248 SHAVNMAGLIQATAHWLLTERPFKH--QEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + +A L + L + + + + N ++A R G+ G + +G+ Sbjct: 240 DDTLAIAALTRCLVRRLARDPSLQRDLTGATHAITAENCWRAQRSGIHGSLMT-ESGEAE 298 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD 354 P+ R L +A +G ++ ++ L R +V+ A + Sbjct: 299 PVPALLSRTLALVAEDGAALGCTAELD-LARWIVARGTSADRQLALFTE 346 >UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseudomonas aeruginosa RepID=CAAL_PSEAB Length = 404 Score = 277 bits (710), Expect = 4e-73, Method: Composition-based stats. Identities = 78/341 (22%), Positives = 137/341 (40%), Gaps = 4/341 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 GIE E +++ D+ + + A ++ E +E+A+ V + + Sbjct: 10 LRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTLAE 69 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 AA ++ + A D L GTHPF W+R + R E+ G + +++ Sbjct: 70 AARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARRSL 129 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHV D + +L + ++P +ALSA+SP+ G + AS R + +P Sbjct: 130 VCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEWPR 189 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 P + + + L I + W IRPS H T+E+R+ D L+ A+ Sbjct: 190 MNIPPALPDEDAYRRHLALLREAGCIREDGQVWWMIRPSSHVPTLELRICDACPRLADAL 249 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 ++AGL +A L P + N +QA RYG G G + Sbjct: 250 SLAGLFRALVGEALGAGPRTLPVARDACLEENYWQALRYGCAGRYL--VGGRAVGAGDWL 307 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + P A + + R ++ + ++ +R + Sbjct: 308 EMAWRQCRPQARQGNEWAY--EHARGLLGETSASRQLRRYQ 346 >UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2Q2P1_9ACTO Length = 333 Score = 250 bits (639), Expect = 6e-65, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 127/316 (40%), Gaps = 11/316 (3%) Query: 23 VNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKV 82 V+ + ++ + +L + VK ++ LE+AT V RD+ A + +++ Sbjct: 2 VHRESWMPAEAAPVLAS-----LGDPRVKPELPACQLEIATSVHRDVADAVAELRTCREL 56 Query: 83 VLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCA 142 V A L + HP + + E + +I + V VH+ Sbjct: 57 VATACAP-DLALVAAPVHPLVE-GPTALSPTEHAAGLSARYRDVISRQLVSSLQVHLAFG 114 Query: 143 SGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQ 202 D + + H L +P AL+A +P+ G D S RP + S P G P +++W Sbjct: 115 DADCTLSVYHALRDLLPELTALAACAPFTAGRDAGLCSVRPVVASQLPRQGVPPIITSWH 174 Query: 203 QFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAH 262 Q+ + + + W++RP +GT+E+RV+D T + +A + A Sbjct: 175 QYAEDLNWAVQGGAVANASEWWWELRPHLRYGTLELRVLDVQATTAQTSAIARFVHALGA 234 Query: 263 WLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAP 320 L E ++ NR+ A R G+ G + D TG+ RP L++ P Sbjct: 235 RLADLHHLGRLEPPAPTWRIAENRWSALRDGVRGELLDLRTGEVRPTRRRLHHLIDTTEP 294 Query: 321 SAHKIGASSAIEALHR 336 A G+ + A+ Sbjct: 295 YAP--GSLDDVRAMVE 308 >UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74515_SYNY3 Length = 389 Score = 132 bits (333), Expect = 2e-29, Method: Composition-based stats. Identities = 59/381 (15%), Positives = 130/381 (34%), Gaps = 37/381 (9%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G+E+E+ ++ S ++ + + + ++ +E T ++ Sbjct: 3 LTKGLEVEIY-TGKKTGEIVGLSDRIVRDLSGFVREPDSRN------VEYTTPPLNSYDR 55 Query: 72 AAGQFSAMQKVVLQAATDHHLE--------ICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 ++ + + + + GGT F + Q Y +E Sbjct: 56 LLCGILQPRRQLRHYLSQLGEDYTLIPGSCLALGGTDTFYRSDPQNP-----YHTYIEQT 110 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 Q H+++G ++ I + P ++ALSA+SP++ G T + SSR Sbjct: 111 --YSTQVVTASIHINIGIPDVEELIRACRLVRMEAPLYLALSASSPFLNGQVTGYHSSRW 168 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPS-----PHFGTVEV 238 +F P +P ++ F + +++ L +RP+ + +E+ Sbjct: 169 QMFPKTPQE--VPLFTSHGHFVQWTEEQLTLGTMQNVRHLWSAVRPNGDNRPHNLNRLEL 226 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKH-------QEKDYLLYKFNRFQACRYG 291 R+ D + + L++A +L + + L N A Sbjct: 227 RICDLVTNPLSLLAIVALLEARLQQMLADPTLDPLQQSQLTPSELLALADQNEISAAVSS 286 Query: 292 LEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDF 351 L+ + G E L + + A G + + L R+++ N+AQ Sbjct: 287 LDSTLHHWRDGRAIAAREWIEELYQSVQLEAKYQGFACFLPPL-RKILREGNQAQQWLTQ 345 Query: 352 VADGGSLIGLVKKHCEIWAGD 372 G + +V++ + Sbjct: 346 YEQGKTPQTIVQEAILQTEME 366 >UniRef50_Q31KY6 Glutamate--cysteine ligase, putative n=24 Tax=cellular organisms RepID=Q31KY6_SYNE7 Length = 384 Score = 131 bits (329), Expect = 5e-29, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 112/358 (31%), Gaps = 29/358 (8%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G E+E+ S L D + + + + +E T ++ Sbjct: 9 LTKGFEVEV-----YTGTPSGQVVGLSDRICSDLQG--FMREPDSRNVEYTTPPRPCYDR 61 Query: 72 AAGQFSAMQKVVLQAATDHH-LEICGGGTHPFQKWQRQ-EVCDNERYQRTLENFGYLIQQ 129 ++ + + G T Y +E Sbjct: 62 LLLDLLEPRRRLRAYLQQQGGYTLIPGSTLALSGGDHFYRSDPTNPYHDFIER--SYGTT 119 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 H+++G + + + + P ++ALSA+SP++ G T S+R + F Sbjct: 120 VVTASIHINIGLSDPETILKACRLVRLEAPLYLALSASSPFLDGQVTGSHSTR---WQLF 176 Query: 190 PDNGPM--PWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP-----HFGTVEVRVMD 242 P P P + F + +++ L +RP+ +E+R+ D Sbjct: 177 PKT-PPEVPLFESHAHFIRWTEAQLAAGSMQNVRHLWSSVRPNGDRRPYKINRLELRICD 235 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKH-------QEKDYLLYKFNRFQACRYGLEGV 295 + + L++A LL + ++ L N A R+ L+ Sbjct: 236 LVANPLDLLAITALLEARLQQLLEQPQLDPLIASRLTPDELVQLSDANEVAAARHSLDAD 295 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA 353 + G + L E + P A G S + + R + G Q +R A Sbjct: 296 LQHWQDGRTIAARDWIETLYETVFPLAKTRGYSCFLLPIQRLLQDGNLAQQWLRQVAA 353 >UniRef50_B0KFE7 Methyltransferase small n=1 Tax=Pseudomonas putida GB-1 RepID=B0KFE7_PSEPG Length = 461 Score = 119 bits (300), Expect = 1e-25, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 64/182 (35%), Gaps = 18/182 (9%) Query: 199 SNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 ++W +E L T + + D W IRPS + TVE+R+ D L + +A L Sbjct: 284 ADWPDYERYLDLLLRTGVRPDV-DCWWAIRPSRRYPTVELRIADGCPRLEDGLCIAALFY 342 Query: 259 ATAHWLLTERPF--KHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 + + + + + N ++A RYG +G D + E +L Sbjct: 343 EMVTHCIEVGREINLLTRETHWVTQENLWRAMRYGRDGRFIDLSSLAPLSAREWLFQLQA 402 Query: 317 KIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD--------GGSLIGLVKKHCEI 368 + ++ +A+ ++++ + A +L +V Sbjct: 403 RF-----ELADVHIDQAV--RILTTGSSADQQLKVYDQAVTRGLAHELALQDVVDLLVNQ 455 Query: 369 WA 370 A Sbjct: 456 TA 457 >UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFC0_9BACT Length = 417 Score = 107 bits (269), Expect = 4e-22, Method: Composition-based stats. Identities = 69/404 (17%), Positives = 137/404 (33%), Gaps = 64/404 (15%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELAT-DVC 66 GIELE +V+ + ++ + T +V +++ +LE T Sbjct: 12 FGIELEYMIVDRDTLRPRPIAESILLDENGETTQEISLGSIDVSNELATHVLEFKTAGPT 71 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC--DNER-----YQRT 119 D+ Q F+A + H+ + G HPF + +R Y R Sbjct: 72 ADLEQLERDFAAAITEMNDRLAVHNAMLAPTGIHPFMDPAIESTTWSKGDRTIYDAYDRI 131 Query: 120 LE--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 + G+ Q+ H+++ A+ ++ L + +P+ ALSA+SP+++G Sbjct: 132 FGCSSHGWFNLQS----CHINLPFANEEEFARLHTAIILILPYLPALSASSPFIEGEYRG 187 Query: 178 FASSRPNIF----SAFP-DNG--PMPWVSNWQQFEALF-------------------RCL 211 F +R +++ + P G + + +++ L Sbjct: 188 FLDTRLDVYKNNQAKVPEIAGDIVPEAIFTYADYQSQILEKTYAAIKPYDPDGILQYEWL 247 Query: 212 SYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT---ER 268 + I +D R + +E+RV+DT + +A LI A L + E+ Sbjct: 248 NSRGAIA-----RFD-RNA-----IEIRVLDTQENPKQDIGIASLIIALLEKLCSLNIEK 296 Query: 269 PFKHQEKDYLLYKFNRFQA-CRYGLEGVITD---PHTGDRRPLTEDTLRLLEKIAPSAHK 324 + + +F A + G E ++ +T P L KI + Sbjct: 297 LKQLALSHTSKQRKAQFLAVAKDGFEADLSVRDLANTFGLNPNETTVGELWAKIVEALKD 356 Query: 325 IGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 + ++ + A+ M V L E+ Sbjct: 357 HPRVAKRTTALGYILQEGSLAERMIARVGTKPDQEDLKSTLAEL 400 >UniRef50_B7K137 Glutamate/cysteine ligase n=9 Tax=Cyanobacteria RepID=B7K137_CYAP8 Length = 380 Score = 105 bits (262), Expect = 3e-21, Method: Composition-based stats. Identities = 54/367 (14%), Positives = 132/367 (35%), Gaps = 28/367 (7%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 + G+E+E+ + S ++ ++ + + ++ +E T + Sbjct: 2 RLSKGLEIEIY-TGTADGQIIGLSDRIVKDLEGFVREPDARN------VEYTTAPLCCYD 54 Query: 71 QAAGQFSAMQKVVLQAATDHH-LEICGGGTHPFQKWQRQEVCD--NERYQRTLENFGYLI 127 + + + Q T+ + G T R D N + + +G Sbjct: 55 RLLCAILRPRHDLRQYLTNIGNYTLIPGSTLSLGNSDRFYRSDPHNPYHSYIEQTYG--- 111 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 H+++G + + + + P ++ALSA+SP++ G T + S+R ++F Sbjct: 112 TNVVTASIHINIGISDPEILMQACRLVRLEAPLYLALSASSPFLDGQVTGYHSTRWHLFP 171 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP-----HFGTVEVRVMD 242 PD +P ++ F + +++ L +RP+ + +E+R+ D Sbjct: 172 QTPD--HVPLFTSHAHFIQWTEEQLALKTMQNVRHLWTSVRPNGDNRPYNVNRLELRICD 229 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKH-------QEKDYLLYKFNRFQACRYGLEGV 295 + +++ L++A L+ + E+ + N + L+ Sbjct: 230 LVVEPIALLSIVALLEARLSQLINDLSLDPLTQSQLSPEELLKITAQNERAVAKDSLKAQ 289 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + G + + L + + +A + G S + L + + G Q +R G Sbjct: 290 LNHWQDGREIWVQDWIEELYQDVWLTAKQGGFSCFLSPLKKLLREGNLAQQWLRK-YESG 348 Query: 356 GSLIGLV 362 + ++ Sbjct: 349 QDIPSIL 355 >UniRef50_Q39ZU6 Gamma-glutamylcysteine synthetase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q39ZU6_PELCD Length = 462 Score = 104 bits (259), Expect = 6e-21, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 129/420 (30%), Gaps = 84/420 (20%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLS--QDSSMLIDAVK------NKITAGEVKHD 53 L + + + +G+E+E VV+ + L+ ++ + AG + Sbjct: 23 QLRNIRPRDQWGVGVEVEKLVVDRQTGQAAEFSRIEALLSHLESAGGWQGQREAGRLIAL 82 Query: 54 ITES---------MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQK 104 + ES LEL+ +C D+ S + + AA L G G HP Sbjct: 83 MGESSSVTLEPGGQLELSGKLCTDLCCCQRDLSRHVRRIDSAARPLGLAFLGLGVHPITP 142 Query: 105 WQRQEVCDNERYQRTLE---NFGYLIQQA--TVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 Q + RY E G L Q G V++ D + + P Sbjct: 143 LQDIDWLPKPRYAIMREYMLRTGDLGQHMMKLSAGLQVNLDFCDEADCMDKIRTGQLLAP 202 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAF-------------PDNGPMPWVSNWQQFEA 206 F AL A SP M G + F S+R I++ P G +V Sbjct: 203 LFYALFANSPLMNGKPSGFLSTRGEIWARTDPDRSGIILELFRPGAGLSSYVDYALDVPM 262 Query: 207 LFRCLSYTTMID-------------------SIKDLHWDIRPSPHFGTV------EVRVM 241 F L +ID WD+ S F V E+R Sbjct: 263 YF-ILRQGHLIDLTRRRFSFRRYLSEGFEDFRPTLADWDLHLSTLFPEVRLRPQIELRSA 321 Query: 242 DTPLTLSHAVNMAGLIQAT-----AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 D+ A+ +A L + A + + + + + N + R GL Sbjct: 322 DSLP-PHLAMAVAALAKGLMYDDEARYQVAKLLDPGDDAQRMEVYRNSW---RLGLR--- 374 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEAQLM 348 L E LL ++G + ++ + SG+ A+ + Sbjct: 375 ---TPCGNHTLREVACELLAVAREVLRRVGPRDCPCGSEARFLDGIEEVAHSGVTLAERL 431 >UniRef50_Q2JXJ9 Glutamate-cysteine ligase, family 2 n=7 Tax=Bacteria RepID=Q2JXJ9_SYNJA Length = 489 Score = 99.9 bits (248), Expect = 1e-19, Method: Composition-based stats. Identities = 80/443 (18%), Positives = 130/443 (29%), Gaps = 89/443 (20%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 F P G ELE +V P D + +S ++AV + + V ++ +EL + Sbjct: 45 PFAQGSPVG-GFELEAWLVTPQ-GDPAPINSAYLEAVNDPL----VVPELARFNIELNSR 98 Query: 65 VCRDINQAAGQFSAMQ----KVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDNERYQ 117 + A Q + A + G P + Q+ + +RY Sbjct: 99 PQVLVASALQQLRQELEQRWDRCCRVAEQLQAGLMTIGILPTLQQQQLTLEMISPRKRYL 158 Query: 118 RTLENFGYLIQQ------------------------------ATVFGQHVHVGCASGDDA 147 E L ++ A +H+ A A Sbjct: 159 ALNEQILNLHRREQPSRIPPLGLTIEGPATLLRVTHPNVMLEAATTSFQIHLQVA-PHQA 217 Query: 148 IYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSN------- 200 + +AL+A SPY+ G D +A +R +F +GP P Sbjct: 218 ARYFNASLLVSAPLVALAANSPYLFGHD-LWAETRIPVFEQ-ALDGPPPLAPTHQPRVTF 275 Query: 201 -------------WQQFEALFRCLSYTTMI---------DSIKDLH-WD-----IRPSPH 232 W+ L T + W+ + P PH Sbjct: 276 GQGYVQESLMELFWENLRCYPVVLPQTLAASPWELAHLRLHNGTIWRWNRPLVGVDPYPH 335 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 +E RV TL + A L QE + + N + A R+GL Sbjct: 336 LR-IEQRVAAAGPTLPDMIANAAFYFGLVQALGARPLPPEQELSFAQCRANFYAAARFGL 394 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKI-----GASSAIEALHRQVVSGLNEAQL 347 E IT + L+ + ++ + L +V SG N A Sbjct: 395 EAPITWLNGWQGSLRQLLLQELIPQAEAGLAQLDLAPQDIQEYLGILRARVESGQNGATW 454 Query: 348 MRDFVADGGSLIGLVKKHCEIWA 370 R +VA G + + C W Sbjct: 455 QRRYVARHG--KDMQQLTCAYWE 475 >UniRef50_Q2BQQ6 Putative uncharacterized protein n=1 Tax=Neptuniibacter caesariensis RepID=Q2BQQ6_9GAMM Length = 498 Score = 99.5 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 63/440 (14%), Positives = 125/440 (28%), Gaps = 104/440 (23%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 PDF + ++G ELE+ +V+ L+ + ++ + ++ ++ LE Sbjct: 36 PDFGKGDT-SIGAELELYLVDKQARPLALNREII-----ERSGHPQLALELNRFNLEYNL 89 Query: 64 DVCRDIN----QAAGQFSAMQKVVLQA-ATDHHLEICGGGTHPF---QKWQRQEVCDNER 115 + Q G+ ++ + + + + G P + Q + D R Sbjct: 90 KPVKAAGKPFSQLEGEMLDAIALINKHIEAEQGVAL-PVGILPTLKRSDFGLQAMTDESR 148 Query: 116 YQRTLENFGYLIQQATV----------------------FGQHVHVGCASGDDAIYLLHG 153 + + L + +H D + + Sbjct: 149 FFALTQALQRLRGRMFCINIDGDPPISLRSKDVTLEGANSSMQIHYRVE-PDQFASMFNA 207 Query: 154 LSRFVPHFIALSAASPYMQG----TDTRFASSRPNIFSA------------------FPD 191 L P +ALSA SP+M G +TR R I + Sbjct: 208 LQLVTPVILALSANSPFMLGHKLWHETRIPLFRQTIDGRSHEECSRGVPSRVDFGSGWVR 267 Query: 192 NGPMPWVSNWQQFE---------ALFRCLSYTTMIDSIKDLHWDIRPSPHFGTV------ 236 G + + + I S+++L R GTV Sbjct: 268 EGAYELFAEMVHLHEPIIPVVDSENVQSIIKQGGIPSLEEL----RMHS--GTVWPWNRA 321 Query: 237 ------------EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR 284 E+R + + T S A + A L + + N Sbjct: 322 VYDQNNGGHLRIEMRSLPSGPTPSDMAANAAFVLGAARGLQALMDEIIPSMPFSVLVNNF 381 Query: 285 FQACRYGLEGVI--TDPHTGDR--RPLTEDTLRLLEKIAPSAHKIGASS------AIEAL 334 +QA G++ + P G P+ E +L + ++ + + Sbjct: 382 YQAAEKGMQAELMWITPDAGGLKKVPVMEIARQLWPHVQKGLDQL-CVDKDEQTHYLSIM 440 Query: 335 HRQVVSGLNEAQLMRDFVAD 354 ++ +G+N A R Sbjct: 441 DERLKTGINGAVWQRREFMR 460 >UniRef50_A0YFA7 Putative uncharacterized protein n=2 Tax=unclassified Gammaproteobacteria RepID=A0YFA7_9GAMM Length = 493 Score = 96.8 bits (240), Expect = 1e-18, Method: Composition-based stats. Identities = 70/431 (16%), Positives = 135/431 (31%), Gaps = 96/431 (22%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F ++G ELE+ +V G L + ++ +++ ++ ++ LE Sbjct: 36 PAFGTGN-SSIGAELELYIVGTDGNPLYANQEII-----DELKDPQLTVELNRYNLEYNL 89 Query: 64 DVCRDINQA----AGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERY 116 R A + + V AA + I G P + V + +RY Sbjct: 90 TPYRLARSAFSSIEEEIVKKLREVNAAAAIYDGRIVAIGILPTLKRSDFGDHSVTERKRY 149 Query: 117 QRTLEN--------FGY---------LIQQATVF-----GQHVHVGCASGDDAIYLLHGL 154 Q + F L + F VH D A + + + Sbjct: 150 QALMSQLIKRSGTQFRIDVNGEDPLKLTMEDITFEGANTSFQVHYRVNPIDFA-DIYNAI 208 Query: 155 SRFVPHFIALSAASP---------------YMQGTDTRFASS-------RPNIFSAFPDN 192 P +A+ A SP + Q DTR + R N + + Sbjct: 209 QVVTPLAVAIGANSPTLFGHSLWHETRVPLFKQSIDTRHTDAYRWRNPARVNFGQGWLRH 268 Query: 193 GPMPWV-SNWQQFEALF--------RCLSYTTMIDSIKDLH--------WDIRP------ 229 + + + AL + + S+ +L W+ RP Sbjct: 269 NAVDLFRETVRIYPALLPICAQHSSKQQQEDGEVPSLAELRLHLSTVWLWN-RPVYDDAE 327 Query: 230 --SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQA 287 +E+R + T V A + A + + + L ++N ++A Sbjct: 328 GGHLR---IEMRALPAGPTAVDMVANAAFLIGLAEGIRPQINELLPALPFHLAEYNFYRA 384 Query: 288 CRYGLEGVITDPHTG----DRRPLTEDTLRLLEKIAPSAHKIG-----ASSAIEALHRQV 338 ++GL+ + PH G + +T+ +LL IG + + + R++ Sbjct: 385 AQHGLDAKLVWPHLGQHGYREQTITDIIDQLLPCAQQGLDAIGVPLEESKRYLSVIQRRL 444 Query: 339 VSGLNEAQLMR 349 + N A + Sbjct: 445 IRKQNGAIWQQ 455 >UniRef50_A2BYV9 Uncharacterized conserved protein n=7 Tax=Prochlorococcus marinus RepID=A2BYV9_PROM5 Length = 372 Score = 96.4 bits (239), Expect = 1e-18, Method: Composition-based stats. Identities = 52/320 (16%), Positives = 121/320 (37%), Gaps = 21/320 (6%) Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNER-YQ 117 +E T+ +D + +K + Q ++ L I T F+ + + D Y Sbjct: 45 VEYITNPEKDYKVSYQNLLEPRKHLRQWLSNRDLTIIPSSTLCFKHDSKFQRSDKNNVYH 104 Query: 118 R-TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 + +N+G I H+++G + D + + ++++SA+SP++ T Sbjct: 105 QFIQDNYGISIA---TSSVHINLGIDNLDKLFAAIRLVRCEASLYLSISASSPFLNNKIT 161 Query: 177 RFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPS----PH 232 S R F P+ +P+ +N + + + +I+ IRP+ PH Sbjct: 162 NNHSQRWIQFPKTPN--KVPFFNNHENYIQWIDENIKKGKMHNIRHFWSSIRPNGPQRPH 219 Query: 233 -FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQ--------EKDYLLYKFN 283 +E+R+ D + + + L++ L ++ + N Sbjct: 220 VLDRLELRICDYVSDIDLLLAITALLELRVIHLFENMTTLDPLITSQFSMDQLTKICDQN 279 Query: 284 RFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLN 343 +A + L+ + G + E LL +++ +A K ++ +++ + G Sbjct: 280 EIKAAQNSLDAELIHWRDGKKVICREWIRDLLVELSLTAEKFDMVHLLKPIYKVLDEGNQ 339 Query: 344 EAQLMRDFVADGGSLIGLVK 363 ++ +G S+ ++K Sbjct: 340 SMNWIKQ-YREGLSIEDIMK 358 >UniRef50_D2L0B8 Glutamate--cysteine ligase GCS2 n=2 Tax=Desulfovibrio RepID=D2L0B8_9DELT Length = 421 Score = 94.9 bits (235), Expect = 4e-18, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 107/300 (35%), Gaps = 34/300 (11%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV-------KHDITESMLEL-ATDV 65 GIE+E +V+ + + L+ A + A +V +++ +LE+ + Sbjct: 11 FGIEIEYMIVDRETLAVLPVADRLLAAAAGREGAADVDMGKLTWSNELVNHVLEMKVSQP 70 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEVCDNER---YQRTLE 121 ++ A F+A + G HP + +E Y+ Sbjct: 71 APSLSGLAATFAAHVAKADTLLAPFGGRLMPTGAHPLMDPPAETVLWPHEHGEIYRTFDA 130 Query: 122 NFGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 F + + HV++ ++ L + +P AL+A++P + G T F Sbjct: 131 IFDCKGHGWSNLQSMHVNLPFRGDEEFGRLHAAIRVLLPIMPALAASTPILDGKFTGFLD 190 Query: 181 SRPNIFS----AFPD---NGPMPWVSNWQQFE--------ALFRCLSYTTMIDSIKDLHW 225 +R + +S P V + Q++ + ++ Sbjct: 191 ARMDRYSHNADRVPSVMGAVIPEAVFSEQEYRDRILAPLYRDIAPMDPQGVLQDE---FL 247 Query: 226 DIRPS-PHF--GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF 282 + R + F T+E+RV+DT + + +AG++ A L+ ER +E+ + Sbjct: 248 NARGAIARFDRSTIEIRVLDTQECPAADLALAGVVVAALKGLVEERWSTFEEQKAWDTRE 307 >UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD82_9ACTO Length = 122 Score = 94.9 bits (235), Expect = 4e-18, Method: Composition-based stats. Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 1/113 (0%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 T+G+E E +V+P L+ ++++ A+ V +I + LE +T VC + Sbjct: 11 PGVTVGVEEEFHLVDPDTLVLTPGTTVVAAALAGDA-GEHVHPEIVSTQLETSTGVCATL 69 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + + SA + AA L + THPF W+ Q + RY+ + Sbjct: 70 PELRTELSATRAEAAAAAARDGLALLAASTHPFGTWREQRLTAAPRYRDRAQR 122 >UniRef50_A3ZWT8 Putative uncharacterized protein n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZWT8_9PLAN Length = 405 Score = 92.6 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 59/417 (14%), Positives = 134/417 (32%), Gaps = 79/417 (18%) Query: 8 VSEPFTL----GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITES 57 +S+P L G+ELE +V+ D+ + +L++ +I + +++ Sbjct: 1 MSDPLHLFDAYGVELEYMIVDAQSLDVRPIADLLLEKAAGEIISEVELGELAWSNELALH 60 Query: 58 MLELAT-DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNER- 115 ++EL T ++ F + + + HP+ ++ ++ Sbjct: 61 VIELKTNGPAASLDPLTDYFQQHVTQANEYLSSLGARLLPTAMHPWMDPHTVQLWPHDYN 120 Query: 116 -----YQRTLENFGY-LIQQATVFGQHVHVGCA--SGDDAIYLLHGLSRFVPHFIALSAA 167 Y R + G+ + VH+ D+ L + +P AL+A+ Sbjct: 121 PIYQAYNRIFDCRGHGWANLQS-----VHLNLPFCGDDEFGRLHAAIRLIMPLLPALAAS 175 Query: 168 SPYMQGTDTRFASSRPNIF----SAFPD---NGPMPWVSNWQQFEALFRCLSYTTMIDSI 220 SP G + F +R ++ P + ++ Sbjct: 176 SPICDGKPSGFLDTRMEVYRTNSQRIPSLTAAIVPEPIYTEGDYQREI-----------F 224 Query: 221 KDLHWDIRPS-----------------PHF--GTVEVRVMDTP----LTLSHAVNMAGLI 257 + ++ DI P F G +E+RV+D L+ + + Sbjct: 225 EKMYADIEPHDPEGMLQYPFLNARGAIARFDRGAIEIRVLDIQECPAADLAILQAVVATL 284 Query: 258 QATAH---WLLTERPFKHQEKDYLLYKFNRFQACRYGL-EGVITD--PHTGDRRPLTEDT 311 +A E+ L+ A + +G + ++ +RP + Sbjct: 285 KALVSEKWTSFAEQQLVATMPLSQLFLETIRTADTTPITDGDLLRQFGYSARQRPTVAEL 344 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-MRDFVADGGSLIGLVKKHCE 367 R + ++G + A E+ +++ A+ ++ D L + + E Sbjct: 345 WRHI------LAELGQTPAEESPLDVILTDGPLARRILQKAGHDLSHLQPVYSELAE 395 >UniRef50_B9ZKM7 Putative uncharacterized protein n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZKM7_9GAMM Length = 478 Score = 91.4 bits (226), Expect = 4e-17, Method: Composition-based stats. Identities = 68/429 (15%), Positives = 130/429 (30%), Gaps = 84/429 (19%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD-- 68 P LG E+E + + G L + +++++ + + ++ + LEL + V + Sbjct: 43 PPRLGFEIEAWLCDAAGRPL-PVNQGVLESMDSPLA----TLELAQFNLELNSSVFQVGP 97 Query: 69 --INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRT---- 119 + + + +AA H E+ GT P + + + RY+ Sbjct: 98 GCFAAILSELNETLRQARRAARHHQAELLMAGTLPTIQPEDLGLHHMSPQARYRALNTAV 157 Query: 120 ---------------LENFGYLIQQATVFGQ----HVHVGCASGDDAIYLLHGLSRFVPH 160 E+ + + + VH A + Sbjct: 158 LEQRAQRPLKLDIVGREHLQHAHRDVMLEALATSFQVHTETR-PAVAHRAYNASLVASAP 216 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAF--------PDNGPMPWV-------------- 198 +A + +P++ G D S R +F GP+ V Sbjct: 217 VLAAAGNTPFVFGHDLWCES-RIPVFEQSVEVGGFADSARGPIRRVTFGTGYLHHSIGEL 275 Query: 199 --SNWQQFEALFRCLSYT------TMIDSIKDLH-W-------DIRPSPHFGTVEVRVMD 242 N + F L + + W D R + +E R + Sbjct: 276 FTENLEHFPVLLPARLDAPSRELRHLALHNGTIWRWTRPIVGVDDRGHRNLR-LEFRCLP 334 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 TL + L+ P + + N + A RYGL+ + Sbjct: 335 AGPTLIDMLANTAFAMGLTEHLIHGSPDGTLGTPFSEARDNFYNAARYGLDARL-RWGHA 393 Query: 303 DRRPLTEDTLR-LLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 + P R LL + A ++G ++S + + + + AQ RD+V G Sbjct: 394 EPEPAPRLIRRHLLPRAAAGLERLGVDPAESNSLLGIIAARTATRQTGAQWQRDWVERHG 453 Query: 357 -SLIGLVKK 364 GLV+ Sbjct: 454 RDWSGLVRA 462 >UniRef50_B9TDX9 Putative uncharacterized protein (Fragment) n=1 Tax=Ricinus communis RepID=B9TDX9_RICCO Length = 529 Score = 90.3 bits (223), Expect = 1e-16, Method: Composition-based stats. Identities = 67/415 (16%), Positives = 133/415 (32%), Gaps = 68/415 (16%) Query: 4 PDFHVSEPFT----LGIELEMQVVNPPGYDLSQDSSMLID---AVKNKITAGEVKHDITE 56 P+ + P + GIELE +V+ + + L D ++ + +++ Sbjct: 126 PEERMKTPLSAFAGYGIELEYMIVDRETLSIKPIADRLFDDAGSLHQEHDRIGCSNELVL 185 Query: 57 SMLEL-ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNER 115 +EL D+ F + + A T + + HP W + + Sbjct: 186 HQIELKNDHPTADLEALPIWFMEKIQRINSALTVFNARLMPSAMHP---WMN-PITETRL 241 Query: 116 Y-QRTLENFGYLIQQATVFGQHVH---------VGCASGDDA--IYLLHGLSRFVPHFIA 163 + R E + + +F H H V DDA L + +P A Sbjct: 242 WPHRQAEIYQAYER---IFDCHRHGHANVQSMQVNLPFADDAEFARLHEAVRWALPLIPA 298 Query: 164 LSAASPYMQGTDTRFASSRPNIF----SAFP-DNG--PMPWVSNWQQFEAL--------F 208 L+A+SP+ G + F R ++ P G V++ ++ + Sbjct: 299 LAASSPFADGQWSGFMDYRLEVYRTHQQRVPSTAGELIPEPVTSPAEYRSKILVPMFKEI 358 Query: 209 RCLSYTTMIDSIKDLHWDIRPS-PHF--GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLL 265 ++ ++R + P F +E+R+ D + +A I A L Sbjct: 359 APYDPEGVLQHE---WLNVRAAVPRFERSAIEIRLADVQECPQADIAIAAAIIALVRHLY 415 Query: 266 TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH-------TGDRRPLTEDTLRLLEK- 317 L++ + + VITD G+R E L+++ Sbjct: 416 DNTGDWPTADTTNLFRILK-STMLDAEQAVITDSVYLRRLGYAGERCTTRELWQFLIDQP 474 Query: 318 --IAPSAHKIGASSAIEALHRQVVSGLNEAQLMRD---FVADGGSLIGLVKKHCE 367 P G + ++ A+ +R+ A+ L ++ C+ Sbjct: 475 LSSLPLLQPWG------PTLQLILKHGTLARRLRNHIGIKAERTKLDATYRELCD 523 >UniRef50_Q1DCU0 Glutamate-cysteine ligase, family 2 n=2 Tax=Myxococcales RepID=Q1DCU0_MYXXD Length = 496 Score = 89.5 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 65/440 (14%), Positives = 120/440 (27%), Gaps = 102/440 (23%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F V P T+G ELE+ +V+ G+ L + AV + V ++ LE+ Sbjct: 36 PGFGVGAP-TVGAELELYLVDRLGFPL-----PVNRAVLARAEDPRVTLELDAFNLEVNL 89 Query: 64 DVC----RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERY 116 C R + + + V +AA+ + G P + RY Sbjct: 90 RPCPLAGRSFSALRQEVESAVSAVRRAASMLGARVAVIGILPTLREADLGSGALTSEPRY 149 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCASGDDAI---------------------------- 148 + +++ F HV ++A+ Sbjct: 150 RAMSTAIRQ--RRSAPF----HVSIRGEEEALSLTWKDVTLEGANTSLQYHLRVAPGDFA 203 Query: 149 YLLHGLSRFVPHFIALSAASPYMQGT----DTRFASSRPNIFSA---------------- 188 + + +A + SP G +TR A R + Sbjct: 204 RMYNAAQLATAPVLAAAGNSPLFLGRKLWDETRVALFRQAVDDRGEPGEGGFQPHARVSF 263 Query: 189 ---FPDNGPMPWVSNWQQF---------EALFRCLSYTTMIDSIKDLH------------ 224 + G + + R + +++L Sbjct: 264 GHGWVREGAYELFAEAVALHPPLLPVSGDEPLRERVAAGEVPDLEELRLHQSTVWSWNRA 323 Query: 225 -WDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 +D + H +E R + TL + + L ++ N Sbjct: 324 IYDPKAGGHLR-IEFRALPAGPTLVDMMANGAFLLGLTLALAERVDALLPALPFVHAYGN 382 Query: 284 RFQACRYGLEGVITDPHTGDRRP----LTEDTLRLLEKIAPSAHKIG-ASSAIEALHRQV 338 +A R GL+ + P + P TE RLL + G + + L + Sbjct: 383 FIRAARQGLDAELLWPSSTAPSPRPMAATELVKRLLPDAREGLVRAGVDAEEADTLLGIL 442 Query: 339 VSGL----NEAQLMRDFVAD 354 + A R +A Sbjct: 443 EQRVVLRRTGATWQRQMLAR 462 >UniRef50_B7AQN9 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQN9_9BACE Length = 403 Score = 89.1 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 43/315 (13%), Positives = 104/315 (33%), Gaps = 76/315 (24%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE----VKHDIT------ 55 F S+ F +GIE+E V + S ++D +K+ + + ++ + Sbjct: 38 FKRSDDFKIGIEIEHFVFDSNDR--SAGYEKILDVMKDIMGEDDKPYYLEGHLIGFYNDR 95 Query: 56 -------ESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 S LE++ C ++ + ++++ + ++L + G +P++ Q Sbjct: 96 YSISLEPASQLEISIAPCASADELVCIYRDFRRILDPVLSRYNLRVECYGYNPYESAQEL 155 Query: 109 EVCDNERYQRTLENFGYLIQQA-----TVFGQHVHVGCASGDDAIYLLHGLSRFV-PHFI 162 ++ +RY+ F + V V + +DAI L+ + P Sbjct: 156 DIIPKKRYEYMDRYFQKAGTRGRNMMRATASVQVSVDYSDENDAIRKY-RLAAILSPVLS 214 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAFPDNG------------PMPWVSNWQQFEALF-- 208 + SP + R ++ G P +++++ Sbjct: 215 LMMDNSPVFEKQPAAMHMVRAYVWD-----GVDADRCVIMDGCLAPDF-SFEKYAEYIMN 268 Query: 209 --------------------------RCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 R ++ ++ + +D+R + +E+R+ D Sbjct: 269 MPAILVMEGETAVYTDDKKIKDIYAERVMTDEEVMHVLSMAFFDVRLKNY---IEIRMAD 325 Query: 243 TPLTLSHAVNMAGLI 257 + + A A +I Sbjct: 326 SC-NIDKAAWYARII 339 >UniRef50_B4VPR5 Glutamate-cysteine ligase family 2 n=1 Tax=Microcoleus chthonoplastes PCC 7420 RepID=B4VPR5_9CYAN Length = 432 Score = 88.7 bits (219), Expect = 3e-16, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 102/329 (31%), Gaps = 63/329 (19%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNK-----ITAGEVKHDITESMLELATDVCR 67 +G+E E +V S + + + + + + + M+E+ T Sbjct: 7 RIGLEQEFFLV-EETGKFSNRADEFLQNCRQEAETIGLNPDYFMPEWVKGMIEINTPPAH 65 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A + ++ LQ HL + ++P + D Y + GY Sbjct: 66 TPTELAIAYLKNLQLGLQVGKKMHLRLYPLSSYPLHLI--PVIRDKLSYHVQVRTVGY-- 121 Query: 128 QQATVF----GQHVHVGCA-----------------SGDDAIYLLHGLSRFVPHFIALSA 166 + G H+H+ ++ I + + + IAL Sbjct: 122 DRFLNAGKCTGTHIHLEVPPGVIDSRVGVSYNSSAAEREELINIYNLATALDSALIALGR 181 Query: 167 ASPYMQGTDTRFASS--RPNIFSAF----------PDNGPMPWVSNWQ-----QFEALFR 209 A P+ +G T A R F G MP+ + + QFE + Sbjct: 182 ACPFYEGEATGLAYHIVRYRGSDRFGWEGVYTHLQSVGGLMPYADSVEQLVELQFERYYA 241 Query: 210 CLSYTTMIDSIKDLH-----------WD-IRPSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 L+ + L W+ +R + GTVE+R +D+ + L+ Sbjct: 242 WLTAMDNAGVERKLFTEGGGNLLKSGWNPVRLNA-LGTVELRGIDSN-YPDVIFTIMRLV 299 Query: 258 QATAHWLLTERPFKHQEKDYLLYKF-NRF 285 A + E + ++ N + Sbjct: 300 YNAARRVRQEGITVRPAQGAHTFELRNDW 328 >UniRef50_C8QVM0 Glutamate--cysteine ligase GCS2 n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QVM0_9DELT Length = 415 Score = 87.2 bits (215), Expect = 8e-16, Method: Composition-based stats. Identities = 66/386 (17%), Positives = 131/386 (33%), Gaps = 53/386 (13%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLI----DAVKNKITAGEV--KHDITESMLELAT-DVCR 67 GIELE +V+ + + L+ AV N++ GE+ +++ + +LEL T Sbjct: 20 GIELEYMIVDHRTLAVRPLADRLLIGPDGAVVNEVDHGELAWSNELVQHVLELKTNGPAE 79 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR----QEVCDNERYQRTLENF 123 + +F + + HP R NE Y+ F Sbjct: 80 SLVGLGARFHRDLVEINGKLAALGAGLLPTAMHPLFDPARETHLWPYGQNEIYEAYDRIF 139 Query: 124 GYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 G + + H+++ ++ L + +P AL+AASP QG + + +R Sbjct: 140 GCRGHGWSNLQSMHINLPFYDEEEFRRLHAAIRIVLPLIPALAAASPLEQGRRSAWLDNR 199 Query: 183 PNIFS----AFP-DNGP--MPWVSNWQQFEA-LFRCLSYTTMIDSIKDL----HWDIRPS 230 + A P +G V+ + + + + ++ + R + Sbjct: 200 LRYYRDNQKAIPEISGLVVPEPVTGIEDYHRQILEPMYAAIRPHDPNEVLSDEWLNSRGA 259 Query: 231 -PHF--GTVEVRVMDTP----LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 F T+E+RV+D L+ A + L++A L + Q Sbjct: 260 IARFERQTIEIRVIDLQECPAADLAIAEAVVELVRALYKERLAGFAAQ-QALSTEALAEQ 318 Query: 284 RFQA------CRYGLEGVITDPHTGDRRPLTEDTLRLLE---KIAPSAHKIGASSAIEAL 334 ++ G E ++ E +LLE ++P+A + Sbjct: 319 MWRCGEQGSQAEIGSEALLALFGCDRPLTAAELWRKLLEDGLAVSPTA---------AGM 369 Query: 335 HRQVVSGLNEAQLMRDFVADGGSLIG 360 +++ + A+ V GS+ Sbjct: 370 LERIIVRGSLAE---AIVRRLGSVPS 392 >UniRef50_B8KSF5 Glutamate-cysteine ligase, family 2 n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KSF5_9GAMM Length = 504 Score = 86.4 bits (213), Expect = 1e-15, Method: Composition-based stats. Identities = 71/460 (15%), Positives = 138/460 (30%), Gaps = 102/460 (22%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P+F V P ++G ELE+ +++ + S + L++A + ++ ++ + LE Sbjct: 43 PEFGVG-PQSIGAELELYIIDAE-GNPSHINQRLLEAAAD----PQLTLELNKYNLEYNL 96 Query: 64 DVCRDINQA----AGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERY 116 A + + + A I G P + ERY Sbjct: 97 TPHLLAESAFRATEQEMLKKVHQLDRCAAAADARIVPIGILPTLTMDDLTEACITPKERY 156 Query: 117 QRTLENF-GYLIQQATV---------------------FGQHVHVGCASGDDAIYLLHGL 154 L Q + VH A D A + + Sbjct: 157 YALLGELVRLRGGQFEIDIDGAEPLKMKVDNITLEGANTSFQVHQRVAPEDYANR-FNAI 215 Query: 155 SRFVPHFIALSAASP---------------YMQGTDTRFAS-------SRPNIFSAFPDN 192 P +A+ A SP + Q DTR +R + + Sbjct: 216 QLATPLALAIGANSPGLFGHQLWDETRIPLFKQSIDTRHVDPYGWHEPARVSFGHGWCRG 275 Query: 193 GPMPWVSNWQQFEALFRCLS--------YTTMID---------SIKDLH-WDIRPSPHFG 234 P +Q L+ L + + + W+ RP Sbjct: 276 DPHELF---EQMVRLYSPLLPVCEPSSERAGAAEAPELAELRLHLSTVWLWN-RPVYDHV 331 Query: 235 T-----VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACR 289 +E+R M T V A + + L E + ++N ++A + Sbjct: 332 AGGHLRIEMRAMPAGPTAIDMVAGAAFLIGVSTSLADEMESLLPAIPFHYAEYNFYRAAQ 391 Query: 290 YGLEGVITDPHTG----DRRPLTEDTLRLLEKIAPSAHKIGAS-----SAIEALHRQVVS 340 YGL + P G + + + +LL +G S + + R++ + Sbjct: 392 YGLSSRLVWPRRGQYGLEEASVVDVIAQLLPSADDGLAALGVSQSERDRYLGVIERRLAA 451 Query: 341 GLNEAQLMRD--------FVADGGSLIGLVKKHCEIWAGD 372 +N A R + +L +++++ E+ A + Sbjct: 452 RMNGADWQRQCLGQLMGKRYSKTRALKSMLERYRELSASN 491 >UniRef50_Q092K6 Glutamate--cysteine ligase n=2 Tax=Cystobacterineae RepID=Q092K6_STIAU Length = 446 Score = 85.3 bits (210), Expect = 3e-15, Method: Composition-based stats. Identities = 54/333 (16%), Positives = 88/333 (26%), Gaps = 54/333 (16%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 LEL+ R +A + V AA L++ G PF RY+ Sbjct: 101 QLELSGSPFRTAREAHAENLRHLAEVKAAAGPLGLQLVALGYRPFGTTADMPWMPKTRYK 160 Query: 118 RTLENFGYLIQ-----QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 + V A D + ++R P +AL A SP + Sbjct: 161 MMRRTLPERGRLALNMMLMTSTGQVSFDWADEADCVRKTVLVARLSPLMVALYANSPILD 220 Query: 173 GTDTRFASSRPNIFSAF-PD-NG-PMPWVSNWQQFEALFRCLSYT--------------- 214 G + + S R ++ P G + + A Sbjct: 221 GKPSGWLSYRSRVWDEVDPTRCGYLPAFFDGSFSYRAYVEWALDAPLLFLRRRGQYLYPK 280 Query: 215 ------------TMIDSIKDLHWDIRPSPHFGTV------EVRVMDTPLTLSHAVNMAGL 256 + D W S F V EVR D + + L Sbjct: 281 LSFRQLLKEGFEGQPPDMGD--WTDHLSTLFPEVRLKKVIEVRGAD-CASAEMVGALGAL 337 Query: 257 IQATAHWLLTERPFKHQEKDYLLYKFNRFQ--ACRYGLEGVITDPHTGDRRPLTEDTLRL 314 + + + L + F A + GL G + G + L + Sbjct: 338 WRGLLYDAGAMEEAERLLPKLTLAEHRAFHETARQQGLAGRL----NGQQ--LHRLAAEM 391 Query: 315 LEKIAPSAHKIG--ASSAIEALHRQVVSGLNEA 345 + ++ +E L R SG + A Sbjct: 392 VAMARRGLQRLDPQDVPLLEPLERVAASGRSPA 424 >UniRef50_D1REB2 Carboxylate-amine ligase-like protein n=1 Tax=Legionella longbeachae D-4968 RepID=D1REB2_LEGLO Length = 380 Score = 84.5 bits (208), Expect = 6e-15, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 101/294 (34%), Gaps = 27/294 (9%) Query: 11 PFTLGIELEMQVVNPPGYDLS----QDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++G+ELE V++ S + I + ++ + + +EL+T Sbjct: 5 ELSIGLELEANVIDIHTGKASLDFNNRAFQKISSYFLSQGYPAIQTEFDAATIELSTLPY 64 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 +++ A S + + G HP + + D+ L + + Sbjct: 65 HNLDLAFQSLSGCLNAANDFLSQQGYLLLLLGLHPGRGRDELVMTDSS---YCLASLPLM 121 Query: 127 IQQ---ATVFGQHVH--VGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 +Q ++ +G D I L H L ++ ++ +SP +T + S Sbjct: 122 AEQGGPLFYCSYQINLGIGVNDIDYLIPLCHWLQVYMWPCSVITQSSPVFANKNTNYKSY 181 Query: 182 RPNIFSAF--PDNGPMPW-VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGT--- 235 R + + GP+P + N +F+ L ++ +DI P T Sbjct: 182 RVRLNDSLSGSRTGPLPLDIRNLSEFKHYCNHLPDKADTLRQYNVWYDILPKAIDPTHPS 241 Query: 236 ----VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF 285 +E+RV DT + QA ++ K+ LL NR+ Sbjct: 242 AGYRIEIRVADTTA----LSKLYVFTQAMLLSFMSILHKLRT-KESLLLPENRW 290 >UniRef50_A9TJF8 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9TJF8_PHYPA Length = 502 Score = 84.5 bits (208), Expect = 6e-15, Method: Composition-based stats. Identities = 67/431 (15%), Positives = 130/431 (30%), Gaps = 94/431 (21%) Query: 3 LPDFHVS-----EPFTLGIELE---MQVVNPPGYDLSQDSSMLIDAVKNKITAGEV-KHD 53 L DF S + +G E E Q+ + S L+D + ++ V + + Sbjct: 72 LVDFLRSGCKPKSEWRIGTEHEKLGFQL-DTLKRMTFDQISKLLDGMASRFGYERVMEGE 130 Query: 54 ----ITE----------SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 +++ EL+ +D++ + + V + L G G Sbjct: 131 NIIGLSKDGASVSLEPGGQFELSGAPLKDVHACQRELDTHLEQVNIIGKELGLRFAGIGY 190 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLI-------QQATVFGQHVHVGCASGDDAIYLLH 152 P + RYQ + F ++ V++ S D +++ Sbjct: 191 EPKWPLSERPNVPKARYQVIKDYFPKIVITEVGFETMYQTCTAQVNLDFDSEQD---MIN 247 Query: 153 GLSRFV---PHFIALSAASPYMQGTDTRFASSRPNIFSAF---PDNGPMPWVSNWQQFEA 206 L + P AL A SP+ +G + + R ++S F + FE Sbjct: 248 KLRVGLSLQPLATALFANSPFWEGKPAGYKTYRSFLWSQFDDDRTGELPFVFDDDFGFEK 307 Query: 207 LFRCLSYTTM-IDSIKDLHWDI-------------------RPSP-----HFGT------ 235 M + D D+ +PS H GT Sbjct: 308 YTEYALNVPMLMVHRNDNWRDVSGASFKNFMAGKLEAYPGEKPSLNDWMNHLGTMYPEVR 367 Query: 236 ----VEVRVMDTPL----TLSHAVNMAGLI--QATAHWLLTERPFKHQEKDYLLYKFNRF 285 +E+R D A + L Q+ + L R + + ++ +L + Sbjct: 368 LKKYLEMRGADCCPKDFLNALPAFWVGLLYDEQSLKNCLDIIRDWSNDDRGFLRKEVPN- 426 Query: 286 QACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGLN 343 +G++T G L + +L+ + G + L +G+ Sbjct: 427 -------QGILTPFREGT---LQDVAKDVLKLAKDGLARRGLQEGKFLAPLEEVATTGVT 476 Query: 344 EAQLMRDFVAD 354 A+ M + Sbjct: 477 LAERMLKLYEE 487 >UniRef50_Q4FMS2 Glutamate-cysteine ligase family 2(GCS2) n=2 Tax=Candidatus Pelagibacter ubique RepID=Q4FMS2_PELUB Length = 431 Score = 83.7 bits (206), Expect = 1e-14, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 72/221 (32%), Gaps = 23/221 (10%) Query: 12 FTLGIELEMQVVNPPG-----YDLSQDSSMLIDAVKNKI------------TAGEVKHDI 54 F +GIE E + + Y L+ K + + Sbjct: 22 FKIGIEHEKFLFDEKTNKRVDYPTVLKMFSLLSEFGWKPIMEKENIIGLQKQGKSITLE- 80 Query: 55 TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE 114 + +EL+ D +I++A + + Q +L+I G P + Sbjct: 81 PGNQIELSGDKLNNIHEACAESHDYLFELQQVTKKLNLKIVSAGFDPISTLSEVPNNPKQ 140 Query: 115 RYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASP 169 RYQ ++ G L G +++ S D I ++ VP IAL A S Sbjct: 141 RYQVMTKDMPNGGSLSLDMMYRTCGTQLNLDYDSEKDFIKKFKIVNSIVPISIALFANSS 200 Query: 170 YMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRC 210 ++ ++ F+S R ++ G + FE Sbjct: 201 IIEKKNSGFSSYRSKVWQETSRGGLPEVFFDNMDFEKYADF 241 >UniRef50_Q5ZYJ4 AF2307 n=4 Tax=Legionella pneumophila RepID=Q5ZYJ4_LEGPH Length = 418 Score = 83.7 bits (206), Expect = 1e-14, Method: Composition-based stats. Identities = 40/275 (14%), Positives = 97/275 (35%), Gaps = 53/275 (19%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKN------KITAGEVKHDITESMLELAT---- 63 LGIE+E +V+ ++ S +++ A+ ++ + +++ +LEL Sbjct: 22 LGIEIEYMLVDKESLNVQPKSDLILRALAGHQVNEIELGDIAISNELVLHVLELKNNGPK 81 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY----QRT 119 + + + F + + H+L + G HP W + R+ Sbjct: 82 PLHVPVAE---HFQKTIRELQPLLAQHNLLLLPTGAHP---WMDPN-TETIRWPHGNHDI 134 Query: 120 LENFGYLIQQATVFGQH---------VHVGCA--SGDDAIYLLHGLSRFVPHFIALSAAS 168 F ++F +HV + ++ L + +P A++A++ Sbjct: 135 YNQF------NSIFNCQGHGWANLQSMHVNLPYSNEEEFCQLHNATRLILPLLPAIAAST 188 Query: 169 PYMQGTDTRFASSRPNIF----SAFPD-NG--PMPWVSNWQQF-EALFRCLSYTTMIDSI 220 P++ G T SR + P +G ++ +++ E + + Sbjct: 189 PFLDGQATGLLDSRLYFYSRNQQRIPSISGDIIPEFIRTEREYQEQILEPMYRDISPYDP 248 Query: 221 KDL----HWDIR---PSPHFGTVEVRVMDTPLTLS 248 + + + R P +E+R++D+ + Sbjct: 249 EGILQYQWLNSRAAIPKFDMKAIEIRILDSQECVE 283 >UniRef50_D1R9R1 Putative uncharacterized protein n=1 Tax=Parachlamydia acanthamoebae str. Hall's coccus RepID=D1R9R1_9CHLA Length = 416 Score = 82.6 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 116/311 (37%), Gaps = 47/311 (15%) Query: 1 MPLPDFHVSEPFT------LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVK--- 51 M P S T G+ELE +V+ ++ + L+ + + + K Sbjct: 1 MSAPPKEESPRTTWHLFDVFGVELEYMIVDRENLNILPITDQLLYRMLGEYSGDYEKEPI 60 Query: 52 ---HDITESMLEL-ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 +++ +LEL T +NQ F K + + + + HP+ R Sbjct: 61 GWSNELALHVLELKTTKPTSKLNQIHADFQREVKDINKYLEAFNGMLMPTAMHPWMDPHR 120 Query: 108 ----QEVCDNERYQRTLENF-----GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFV 158 + E Y F G+ Q+ H+++ + ++ + L + + Sbjct: 121 EMKLWTHDNKEIYAAFNRIFNCQGHGWSNLQSN----HLNLPFGNEEEFVRLHAAIRMIL 176 Query: 159 PHFIALSAASPYMQGTDTRFASSRPNIFSA----FPDNG---PMPWVSNWQQF-----EA 206 P +L+A+SP ++G T F +R N++ + P ++ + + Sbjct: 177 PLIPSLAASSPIVEGKTTGFYDTRLNVYQSNSAKIPSITAHIIPEVCLSFDDYKTKIFDR 236 Query: 207 LFRCLSYTTMIDSIKDLHWDIRPS-PHFG--TVEVRVMDTP----LTLSHAVNMAGLIQA 259 +++ ++ +++ + R + F +E+R++D ++ + +A +I+ Sbjct: 237 IYQDIAKFDPKKTLQHEWLNARGAITRFNRNAIEIRLIDVQECPKADVAISRAIAEVIRH 296 Query: 260 TA--HWLLTER 268 WL E+ Sbjct: 297 LTQERWLPLEK 307 >UniRef50_D1ACB6 Glutamate/cysteine ligase family protein n=2 Tax=Streptosporangineae RepID=D1ACB6_THECD Length = 399 Score = 82.6 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 65/389 (16%), Positives = 113/389 (29%), Gaps = 78/389 (20%) Query: 6 FHVSEPFTLGIELEMQVVNPPG---YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 F P +G E E V++P + + +A + ++ LEL+ Sbjct: 18 FKTGPPGKVGAETEWLVIDPADPAAHVPLERVRAAAEAGGPLPGRSVITYE-PGGQLELS 76 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + VC + S V L++ G G P ++ + Q + RY+ + Sbjct: 77 SRVCDGLADLHEALSQDLASVRARLAADGLDLVGRGVDPLRRPRLQA--AHPRYRCMYDY 134 Query: 123 -----FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF------VPHFIALSAASPYM 171 + V V D L R+ P +A A SP Sbjct: 135 FAGGGYRETGATMMCSTASVQVCL---DIGADPADALRRWRLAHALGPVLVAAFANSPLR 191 Query: 172 QGTDTRFASSRPNIFSAF------PD----NGPMPWVSNWQQFEALFRCL-------SYT 214 G T S+R I++A P GP W ++ + + Sbjct: 192 AGRRTGLRSTRQAIWAALDPCRTRPVLEAGTGPADPCRAWTRYAIDAPVMLTRPRPGTSD 251 Query: 215 TMIDSIKDLH--WD--------------------IRPSPHFGTVEVRVMDTPLTLSHAVN 252 + W +RP G +E+R++D V Sbjct: 252 GWTGAPGMTFGEWMDKGEPCLDDFAYHLSTLFPPVRPR---GWLELRMIDALPLRYWPVP 308 Query: 253 MAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPLTEDT 311 +A A LL + +D R+ A R+ +TDP L Sbjct: 309 VA-----VATALLDDPQAGRIAEDAARPVAGRWGAAARH----ALTDPA------LALAA 353 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVS 340 R + ++GA+ + + Sbjct: 354 RRCFAAALQALPRLGAAELVPLVADYARR 382 >UniRef50_D0LKS0 Glutamate--cysteine ligase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LKS0_HALO1 Length = 451 Score = 82.6 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 51/354 (14%), Positives = 93/354 (26%), Gaps = 49/354 (13%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 LELA + + + + + + G G PF + ERY Sbjct: 101 QLELAARPVLATADYERDLCSFADDIAEVSEEFDISWLGLGFRPFGRIDEVGWMPKERYA 160 Query: 118 RTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 G L + V++ + +DA + AL A SP + Sbjct: 161 VMRAYMPTRGALAHEMMKRTATAQVNLDFSDPEDAGEKMRAAMGAGFLLTALYANSPIVD 220 Query: 173 GTDTRFASSRPNIFSAF-P-DNG-PMPWVSNWQQFEALFRCLS--------YTTMIDSIK 221 G D+ S R I+ P G + F + + Sbjct: 221 GADSGHQSYRARIWRDTDPDRCGLLPFVFEDGDVFAGYTQWALDVPLFFVYRQGYKPAGG 280 Query: 222 DLH-----------------WDIRPSPHFGTV------EVRVMDTPLTLSHAVNMAGLIQ 258 W + S F V E+R D+ + + L + Sbjct: 281 MTFRRFLREGFEGHRATLDDWALHLSTLFPEVRMKKYLELRGCDSSAR-DLVIALGPLSR 339 Query: 259 ATAHWLLTERPF-KHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 + R E + + GL + G + + E L+ Sbjct: 340 GFLYDREARRATIALTEHLSFAERVTLLRDVAERGLAAQVP----GSKASVGEMARSFLD 395 Query: 317 KIAPSAHKIG--ASSAIEALHRQVVSGLNEAQLMRDFVADG-GSLIGLVKKHCE 367 A + ++ + L +G ++A RD G +++ Sbjct: 396 IAADGLARQDPAETAYLAPLREIAETGRSQADAFRDLWTRTQGDPARIIEALSH 449 >UniRef50_C7NPM2 Glutamate--cysteine ligase GCS2 n=4 Tax=Halobacteriaceae RepID=C7NPM2_HALUD Length = 386 Score = 81.8 bits (201), Expect = 4e-14, Method: Composition-based stats. Identities = 69/381 (18%), Positives = 121/381 (31%), Gaps = 48/381 (12%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 P IE+E V++ G L D + V+ + E +LE+ T C Sbjct: 23 APLRRSIEVEYWVIDDEGR--------LTDPGELSDAGEGVEREFVEPLLEIKTTPCEST 74 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR--TLENFGYLI 127 +F VL+ A+DH + GT + R Q +F Y+ Sbjct: 75 AALRTEFYERLDGVLRRASDHGKRLVPLGTPMHDGEIADRPGERTRIQDRVVGSDFEYVR 134 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD--TRFAS--SRP 183 G H+HV I L+ L P AL +SPY T S R Sbjct: 135 H---CAGTHIHVE-QQPGHVIEQLNTLIALDPAL-ALVNSSPYFGHERLTTGARSQLYRR 189 Query: 184 NIFSAFPDNG-PMPWVSNWQQF-----EALFRCLSYTTMIDSIKD-----------LHWD 226 + P G P+ + +++ ++ + + ++ + Sbjct: 190 MAYETLPHQGRLWPYAEDLEEWAKRLEHRYGEFVTQSIITGFDRERVESYFGPESAVWTP 249 Query: 227 IRPSPHFGTVEVRVMDTPLT------LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY 280 ++ F TVE R D L ++ + A + +R + L Sbjct: 250 VQLRERFSTVEWRSPDAALPSQLLRLADDVASIVSRVTEAAVRIEGDRGGCAAGEIVLP- 308 Query: 281 KFNRFQACRYGLEGVITD-PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 +F A ++ ITD + R + +E P A ++ A + + + Sbjct: 309 ---KFDAVSEYVDAAITDGLDSSAVRSYLDRMGFSVEAYDPLAGEMDAPAELTESQAR-D 364 Query: 340 SGLNEAQLMRDFVADGGSLIG 360 L A + V S+ Sbjct: 365 RRLEYADRLEADVRRVSSITA 385 >UniRef50_C9RNX1 Glutamate--cysteine ligase GCS2 n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RNX1_FIBSS Length = 431 Score = 81.8 bits (201), Expect = 4e-14, Method: Composition-based stats. Identities = 38/314 (12%), Positives = 102/314 (32%), Gaps = 44/314 (14%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVK-------HDITESMLELA-TD 64 G+E+E +V+ ++ + + + K+ +++ +++ +LE Sbjct: 9 RFGVEMEFMIVDRDTLNVLPRADVPLGKDKDGNQLSDIEYDDIGLSNELVSHVLEFKCAH 68 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE------RYQR 118 + +F + + + + HPF ++ + Y R Sbjct: 69 PKSTFDGLGKRFFHEIRRANKKLEKINAMLLPSACHPFMDPAEMQLWPYDCLDIYQTYDR 128 Query: 119 TLENFGY-LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 G+ + H+++ ++ L + +P A++A+SPY+ G T Sbjct: 129 IFNCKGHGWANLQST---HLNLSFDGDEEFGELHAAIRLLLPLIPAIAASSPYLDGKYTG 185 Query: 178 FASSRPNIFSA----FP-DNG--PMPWVSNWQQFEALFRCLSYTTMIDSIKD-----LHW 225 + +R ++ P G ++ ++ + + + Sbjct: 186 YRDARIEVYRHNQDKVPEITGQVIPEQAYSYDEYNRMIFDKVKKAIAPYDTEHLLNHFFL 245 Query: 226 DIRPS-PHF--GTVEVRVMDT--PLTLS------HAVNMAGLIQ---ATAHWLLTERPFK 271 + R + F G +E+R++D + ++ A + +E P Sbjct: 246 NSRGAIARFDRGAIEIRLVDIQECPNADIAIVELEIATLKAIVNGKFAASRENASEAPSA 305 Query: 272 HQEKDYLLYKFNRF 285 + L ++ F Sbjct: 306 ANSVPHTLKEYREF 319 >UniRef50_D2B0V7 Glutamate/cysteine ligase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2B0V7_STRRD Length = 408 Score = 81.4 bits (200), Expect = 5e-14, Method: Composition-based stats. Identities = 54/327 (16%), Positives = 92/327 (28%), Gaps = 55/327 (16%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 FH S +G+ELE V + D + + A+ V + LEL + Sbjct: 25 FHGSAGDQVGVELEFLVFDRTSPDCHVPLARVAGALPPLPGGSRVTFE-PGGQLEL-SGP 82 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + +A + +A A + L + G G P + +RQ RY+ E G Sbjct: 83 AGPLPEAIARLAADVDAARAALREAGLVLAGVGLDPIRPARRQL--RLPRYEAMAEFLGT 140 Query: 126 LIQQATVFGQ---HVHVGCASGDDAIYLLHGLSRFV--PHFIALSAASPYMQGTDTRFAS 180 + V++ + + P A A SP G + S Sbjct: 141 PYGSLMMCSTASIQVNLDLGDR----PAVRWERAHLLGPVLTAAFANSPLSGGRPCGWMS 196 Query: 181 SRPNIFSAF--------PDNGPMPWVSNWQQFEALFRCLS------YTTMIDSIKDLH-W 225 R ++ P G + W ++ R + + W Sbjct: 197 GRQAVWENLDRTRTAPVPATGDPA--AAWAEYLLDARLMLVRENGDRCRTVRDGSTFRDW 254 Query: 226 DIRPSPHF-------------------GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT 266 P+ G +E+R +D V +A A Sbjct: 255 LAAPARPLTLADLAYHATTIFPPVRPRGWLEIRYLDAQRPADWPVCVAV-THALVMDDRA 313 Query: 267 ERPFKHQEKDYLLYKFNRF-QACRYGL 292 + Y + A R+GL Sbjct: 314 AETAIAAAEPY----AGMWPGAARHGL 336 >UniRef50_UPI0001AEDC74 hypothetical protein SalbJ_18393 n=1 Tax=Streptomyces albus J1074 RepID=UPI0001AEDC74 Length = 498 Score = 80.3 bits (197), Expect = 1e-13, Method: Composition-based stats. Identities = 71/435 (16%), Positives = 125/435 (28%), Gaps = 90/435 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P F EP TLG ELEM +V + + A + + ++ LE Sbjct: 33 LTSPGFGAGEP-TLGAELEMFLV-TRDGVPVPRNEEIRRAAAD----PRLVLEVNRYNLE 86 Query: 61 LA-TDV---CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDN 113 T V R + + + V +A H E G P R+ + Sbjct: 87 ANLTPVPLRPRPFTALHDEADTLLEAVRRAGAAHGAEPYCAGLLPTLRPADLTRRNMSPR 146 Query: 114 ERYQRTLENFGYLIQQATVFGQ-------------------HVHVGCASGDDAIYLLHGL 154 RY + G + V G+ +H+ ++ + + Sbjct: 147 GRYAVIDDALGRAGRGLRVSGEQRLRMRSDTFCAQGAASSWQIHLTVR-PEEFTRVHNAA 205 Query: 155 SRFVPHFIALSAASPYMQG---------------------------TDTRF------ASS 181 +A++A SP + G + F Sbjct: 206 QLMTAPVLAVAANSPLLLGRRAWDESRIPWYEQAFGQHRRRVAPADRRSGFGHGWLRGGV 265 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFR-----CLSYTTMIDSIKDLHWDIRPS-----P 231 R A P+ + + ++ R L + L W RP Sbjct: 266 RELAEEAVRRYAPLVPLCSDGDWDRPLRPGGPPALDELR--LHLGTLWWWNRPVYDPAGD 323 Query: 232 HFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYG 291 +E+R + + T + V L+ L E + L + N + A R G Sbjct: 324 GHLRIELRALPSGPTPADMVANTALLTGLI--LDRAAREPGGELPFALARENFYTAARDG 381 Query: 292 LEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGA---------SSAIEALHRQVVSGL 342 + + P G P+ L+ + P A A + + +V++G Sbjct: 382 MAARLWWPA-GPAAPVRLAARDLVRALLPRAAAGLAAAGVADDEVQRWLGVVEARVLTGR 440 Query: 343 NEAQLMRDFVADGGS 357 + A R GS Sbjct: 441 SGAHWQRRTHRALGS 455 >UniRef50_O27977 Uncharacterized protein AF_2307 n=2 Tax=Archaeoglobaceae RepID=Y2307_ARCFU Length = 365 Score = 79.9 bits (196), Expect = 2e-13, Method: Composition-based stats. Identities = 62/366 (16%), Positives = 135/366 (36%), Gaps = 66/366 (18%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE------VKHDITESMLELA-TDVC 66 +G E E + + ++ S ++ + + + ++ + ++EL Sbjct: 2 IGPEHEFSIND-ENFNPVPISDEILKKIGGRTVNEAKLGRVVIGKELQKHVIELKPARPF 60 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV-CDNER-----YQRTL 120 +++ + +L ++ G G HP + + +V +R Y R Sbjct: 61 ESLSEFEETMQEGVEELLSVMD--GYKLLGLGMHPLLRLEDAKVWNHRDRRIYQAYDRLF 118 Query: 121 E--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT---- 174 G+L Q+ +++ +S +A+ L + + +P+ A+++ASP +G Sbjct: 119 NIKQHGWLNIQSY----QLNIPFSSEKEAVELHNKIRVLLPYIAAVASASPICEGKSYYV 174 Query: 175 DTRFASSRPNIFSAFP---DNGPMPWVSNWQQFEA----LFRCLSYTTM-------IDSI 220 DTR R N P ++ +S+ +++ + ++ L ++S Sbjct: 175 DTRLYFYRINQ-KEVPEICNDVIPERISSLKEYRSILNGIYEELRRKGAYVLCREWVNSR 233 Query: 221 KDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY 280 + +R S +E++VMD + V + I+A L E P D L+ Sbjct: 234 GVI---VRFSRKC--LEIKVMDEQECIKSDVALTAFIRAILRAELEELPV-----DVLIE 283 Query: 281 KFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS 340 K N A R G T +P + LL+K A + ++ + ++ Sbjct: 284 KLN--SAMRSG---------TEKLKP---ELKELLKKSKEHADE-EERRYMKVVKLRIEE 328 Query: 341 GLNEAQ 346 G + Sbjct: 329 GSLGER 334 >UniRef50_Q8TY80 Predicted metal-dependent hydrolase of the TIM-barrel fold n=1 Tax=Methanopyrus kandleri RepID=Q8TY80_METKA Length = 483 Score = 79.5 bits (195), Expect = 2e-13, Method: Composition-based stats. Identities = 55/384 (14%), Positives = 116/384 (30%), Gaps = 96/384 (25%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE------------ 49 + F +G+E E+ +++ L++ + +I + + Sbjct: 10 SVESFAERIEVKVGVEEELFLIDRD-GSLTRAADDVIVKAAELLESDSNLLEDCWRTVLG 68 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + + +E T ++ ++++ +AA + L++ HPF+ Sbjct: 69 LDPEPNPAQIEYLTQPLP-PDEVIEACEIGRELIKKAAEELGLQVMLESMHPFESDPLP- 126 Query: 110 VCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGD-------DAIYLLHGLSRFVPHFI 162 + G H++V D + + + L +P I Sbjct: 127 ----------------------INGTHINVMVKLKDQPYMTPKQILVVYNWLWHNLPIII 164 Query: 163 ALSAASPYMQGTDTRFASSRPN--------IFSAFPDNGPMPWVSNWQ------------ 202 A +A +PY G AS R ++A P+++ Q Sbjct: 165 AATANTPYCCGGKNLAASCRLLKSRVLKPNYYAAIKRLEKRPYLTKTQYYGRLRYRLRLR 224 Query: 203 ---QFEALF------RCLSY-------TTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +FE R L + + D SP VEVRV+D + Sbjct: 225 KDTEFEERVVAHPDGRRLVDITPRGPASNVTGDEND-------SPTRNRVEVRVIDNQKS 277 Query: 247 L----SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 + + + GL L + + NR +A G+ G Sbjct: 278 MKYLHDVVMLIVGLS---LEALYIYEVEGKLPPNDPNHFDNRREAIEKGINATFV--ING 332 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIG 326 + L+++ ++ +G Sbjct: 333 REIDAEDALLKIISRVDKFLEHLG 356 >UniRef50_D2RRB5 Glutamate--cysteine ligase GCS2 n=2 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRB5_9EURY Length = 371 Score = 78.7 bits (193), Expect = 3e-13, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 99/274 (36%), Gaps = 45/274 (16%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 L +ELE V+ L+ + ++D + ++ + + MLE+ TD C D+ + Sbjct: 3 LSLELEYWTVD-DTGALA-SARPVLDRI------DDLHAESADPMLEVVTDPCIDVPELR 54 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 + + + V++ A + + GT D R + + G AT Sbjct: 55 EEVTVRLREVIEVAREEGRHLVPLGTP--LGAASVSTSDGPRTRIQRQVLGEAFDNATHC 112 Query: 134 -GQHVHVG-CASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS----SRPNIFS 187 G H+HV + L+ L+ P F AL A+S Y QG + + R + Sbjct: 113 AGTHLHVDQIEGAET--DQLNLLTALDPAF-ALVASSSYDQGHNVAACARSHVYRRACYG 169 Query: 188 AFPDNGPM-PWVSNWQQ--------FEALFRCLSYTTMIDSIKD--------LHWDIRPS 230 P G + P+V + + F+ R + + D + +R Sbjct: 170 DHPRLGQLWPYVEDVAEWDDRIDATFDRFRRQALGLGVEPATFDTHFTPEDSIWAPVRLR 229 Query: 231 PHFGTVEVRVMDTPL---------TLSHAVNMAG 255 FGT+E R D L + +N+ Sbjct: 230 EKFGTIEWRAPDIALPGQILRLVEDVRDILNLVA 263 >UniRef50_Q2RLA4 Putative uncharacterized protein n=1 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RLA4_MOOTA Length = 328 Score = 78.3 bits (192), Expect = 4e-13, Method: Composition-based stats. Identities = 43/267 (16%), Positives = 72/267 (26%), Gaps = 69/267 (25%) Query: 10 EPFTLGIELEMQVV--NPPGYDLSQDSSMLI---------DAVKNKITAGEVKHDITESM 58 P G+E E+ + + P + L+ N +++ + S Sbjct: 2 TPLRFGLEEEVFITEPDKPTLQSLYYLARLLWLDPGYYYTHTACNFNRGKDLRWGLM-SG 60 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E++T V D ++ + I G H F + Sbjct: 61 IEISTGVFPDTGDLVADLRRRRRELAAVCQGL---IVPVG-HLFDQVAPT---------- 106 Query: 119 TLENFGYLIQQATVFGQHVHV-GCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 + G HVHV G + A L F+P L SP Sbjct: 107 ------------NICGMHVHVSGFPDRERA---YRNLVYFLPLLALLVINSPIAGSRRYG 151 Query: 178 FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHW-DIRPSPHFGTV 236 S R W + + + + D+ S GT+ Sbjct: 152 -QSYR------------------WAE-------AFAIGPLREDRLYRFQDLIESKRLGTL 185 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHW 263 E+RV D L + I+A Sbjct: 186 EIRVFDPVWDLERIRILLECIRAVLEA 212 >UniRef50_D0MH09 CBS domain containing protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MH09_RHOM4 Length = 619 Score = 77.9 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 61/424 (14%), Positives = 111/424 (26%), Gaps = 93/424 (21%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV----CRD 68 +G E E+ +V P + + + ++ ++ + ++T LE+ + Sbjct: 40 RIGAEQELFLVEPC-GNPAPVAEQVLKRNRD----PHLVPELTRFNLEINLEPGLLEGDG 94 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLE---- 121 + + Q + D +I G P + RY R E Sbjct: 95 LRRLERQLLERLAHARKLTRDLGDDIALCGILPTIHLSDLTLDNMTPRPRYARLNEAITR 154 Query: 122 ------NFGYLI--------QQATVFGQ----HVHVGCASGDDAIYLLHGLSRFVPHFIA 163 V G VH+ D + +A Sbjct: 155 LRGGPVQLQITGIDELFVQLDSIMVEGCNASFQVHLQV-DPDAFPRCYNAAQLAAAPVLA 213 Query: 164 LSAASP---------------YMQGTDT-------RFASSRPNIFSAFPDNGPMPWV-SN 200 +P + Q DT R S R + + + + + Sbjct: 214 AGVNAPVLFGKRLWHETRIAVFRQAVDTRGGNLYLREMSPRVHFGTDWVRESVLEIYRED 273 Query: 201 WQQF----------EALFRCLSYTTM-------IDSIKDLHW--------DIRPSPHFGT 235 +F E L + + + W + RP Sbjct: 274 LARFRVLLTPESPPEDALNVLEQGGIPRLEALQLFNGTVYRWNRACYGVSEGRPHLR--- 330 Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +E RV+ + T + V A L P H+ D+ + N A R GL Sbjct: 331 IENRVLPSGPTPADEVANAAFWAGLVLELAHREPELHRRMDFDEARGNFIAAARLGLGAH 390 Query: 296 ITDPHTGDRRPLTED-TLRLLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQLMR 349 + G R P LL + G + + + +V S A+ Sbjct: 391 L-TWLDGARWPAQRLILEELLPMARAGLQRAGVDPADIAHYLGLIRERVESRQTGAEWQL 449 Query: 350 DFVA 353 +A Sbjct: 450 RSLA 453 >UniRef50_D2AYM1 Glutamate-cysteine ligase, family 2 n=2 Tax=Bacteria RepID=D2AYM1_STRRD Length = 478 Score = 77.6 bits (190), Expect = 7e-13, Method: Composition-based stats. Identities = 67/429 (15%), Positives = 123/429 (28%), Gaps = 90/429 (20%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA- 62 P F P T+G ELEM ++ P G L ++ V++ + ++ LE+ Sbjct: 36 PGFGTG-PATIGAELEMFLITPDGRPLPRN-----HEVRDAADDDRLVPELGRFNLEVNL 89 Query: 63 TDV---CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ---KWQRQEVCDNERY 116 T + R + + +V AA + G P + + + D RY Sbjct: 90 TPLPIAGRPFSALVRELRETMALVDAAAGTQGGQALAIGILPSLSEFDFTHEALSDESRY 149 Query: 117 QRTLENFGYL----------------------IQQATVFGQHVHVGCASGDDAIYLLHGL 154 + L I ++ VH+ A D A + + Sbjct: 150 RALSRGMRRLRTEPFRVRIEGVEELELEVEGVILESANTSWQVHLRTAPADFA-RVYNAA 208 Query: 155 SRFVPHFIALSAASPYMQGT----DTRFASS----------------RPNIFSAFPDNGP 194 +A+S SP G +TR A R F + +G Sbjct: 209 QLATGPVLAVSGNSPGFLGRRLWEETRIALFEESADDRDVERLDRRDRRVAFGSGWVSGA 268 Query: 195 MPWVSN-WQQFEALFRCLSY------------TTMIDSIKDLHWDIRP--------SPHF 233 + +E + S + + RP Sbjct: 269 EEMFETCVRDYEPVLPMTSEQVPAGEGEAPGLAELRLHQGTVWQWNRPIYDPADGGHLR- 327 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE 293 VE+R + T + A + + ++ + N ++A +GL+ Sbjct: 328 --VEMRALPAGPTPADMAANAAFLLGLTAAMAAG---PVEDFPFAAAYRNFYRAAIHGLD 382 Query: 294 GVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG------ASSAIEALHRQVVSGLNEAQL 347 + P P + L LL ++G + ++ + +V A Sbjct: 383 APMAWPGVEGEVPAAQLALDLLPVAKAGLERVGVDPAEADWA-LDIIRERVRLRRTGAIW 441 Query: 348 MRDFVADGG 356 R V G Sbjct: 442 QRQVVEGLG 450 >UniRef50_D1X937 Glutamate/cysteine ligase family protein n=11 Tax=Streptomyces RepID=D1X937_9ACTO Length = 456 Score = 77.2 bits (189), Expect = 9e-13, Method: Composition-based stats. Identities = 69/383 (18%), Positives = 122/383 (31%), Gaps = 65/383 (16%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSML---IDAVKNKITAGEVKHDITESMLELA 62 F P T+G+ELE + + DL L ++AV+ + + + LEL+ Sbjct: 32 FKTGPPRTVGVELEWLIHDRERPDLPVGQERLDRAVEAVRALPLSAALTFE-PGGQLELS 90 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT--- 119 + + + +A V A L G G P+Q R+ RY+ Sbjct: 91 SQPAGSLMECVDTTAADLAAVRAALDTAGLAPVGLGVDPWQAPLRRL--REPRYEAMEAA 148 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF-VPHFI-----ALSAASPYMQG 173 L+ G + V V +G++ L R+ + H + A A SP+ QG Sbjct: 149 LDRTGPAGRAMMCTSASVQVCLDAGEEEPGPLGYGRRWQLAHLLGAVLVAAFANSPFRQG 208 Query: 174 TDTRFASSRPNIFSAF-PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDI----- 227 T + S+R ++++ P P + L T + ++ W++ Sbjct: 209 RRTGWRSTRQSLWADLDPVRTLAPGSERAPREAWAAHVLDTTVLCIRREEGPWEVPEGLT 268 Query: 228 ----------RPSPHF----------------GTVEVRVMDTPLTLSHAVNMAGLIQAT- 260 RP G +E+R++D + + A Sbjct: 269 FREWIRTGSPRPPVRADLDYHLTTLFPPVRPRGHLELRMIDAQSGPDGWLVPLAVATALF 328 Query: 261 -----AHWLLTE-RPFKHQEKDYLLYKFNRF-QACRYGLEGVITDPHTGDRRPLTEDTLR 313 A + +P + + A R GL DP L Sbjct: 329 DDPEAAETVYRTLKPLAETSGAPAAPRNALWTTAAREGLA----DPE------LRAAATA 378 Query: 314 LLEKIAPSAHKIGASSAIEALHR 336 P+ ++GAS A+ Sbjct: 379 CFGAALPALERMGASGAVRDTVA 401 >UniRef50_B6BSN8 Glutamate-cysteine ligase family 2 protein n=2 Tax=root RepID=B6BSN8_9RICK Length = 431 Score = 76.8 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 28/162 (17%), Positives = 59/162 (36%), Gaps = 5/162 (3%) Query: 57 SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY 116 + +EL+ D +++A + + Q ++I G P K + +RY Sbjct: 83 NQIELSGDKLITLHEACAESHDYLFELKQVTKKLDIKIVSAGFDPISKLKEIPNNPKQRY 142 Query: 117 QRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM 171 + ++ G L G +++ S +D + ++ VP IAL A S + Sbjct: 143 ELMTKDMPLGGELSLDMMYRTCGTQLNIDYNSEEDFVKKFKIVNSIVPISIALFANSSIV 202 Query: 172 QGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSY 213 + ++ + S R ++ + G FE + Sbjct: 203 EKKNSGYLSYRSKVWQSTSRGGLPKLFFEELNFEKYAEFIIN 244 >UniRef50_D0WIV7 Putative glutamate--cysteine ligase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WIV7_9ACTN Length = 423 Score = 76.8 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 56/402 (13%), Positives = 104/402 (25%), Gaps = 83/402 (20%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSS----MLIDAVKNKITA---------GEVKHDI-- 54 + TLG+E+E +V+ G L+ ++ + + G K + Sbjct: 35 KASTLGVEIEHFLVDNTGQPLTYSQPNGVADVLRTLSARYPDVSMHGDDILGVAKPHMNV 94 Query: 55 ---TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + LE++ I ++ V A T + G P +E+ Sbjct: 95 TIEPAAQLEISAGPFESIADMRFALGEFERDVAAALTPVAGRMVALGYDPMLVAADKELI 154 Query: 112 DNERYQRTLENFGYL---IQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 RY + + V + S +DA + S P + Sbjct: 155 PKARYDIMNRYLSAISPSGPRMMRGSASTQVSIDYTSEEDAAAKMRVASALAPLLSLMCD 214 Query: 167 ASPYMQGTDTRFASSRPNIFSAF---PDNGPMPWVS---NWQQFEALFRCLSYTTMIDSI 220 +P +GT R I+ N + ++ + + +D+ Sbjct: 215 NAPVFEGTRAPHRLMRAEIWRYLDPDRCNTVPGCLDAGFSFADYANYILDVPAVVALDAE 274 Query: 221 KDLHWDIR------------------------PSPHFGT-VEVRVMDTPLTLSHAVNMAG 255 + +D R P T VE+R D + A Sbjct: 275 GEARYDTRTFGDIFADRTMTHADIEHALSMVWPDARLKTYVEIRPADALP-IDLACAYEA 333 Query: 256 LIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD-----------R 304 LI+ + E G++ D Sbjct: 334 LIKGIFYGPALGALAAAFE----------------GVDAQDVDDAKTAIMKRGYEAETFS 377 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 R + L+E G ++ L R V + A Sbjct: 378 RNAGDMCDALVEMAYEGL-PAGERGFLDPLARLVKQRITPAD 418 >UniRef50_Q2SQ10 Uncharacterized conserved protein n=2 Tax=Gammaproteobacteria RepID=Q2SQ10_HAHCH Length = 490 Score = 76.4 bits (187), Expect = 1e-12, Method: Composition-based stats. Identities = 63/435 (14%), Positives = 121/435 (27%), Gaps = 97/435 (22%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 PDF V P + G ELE+ +++ G S + ++ AV + + ++ LE Sbjct: 36 PDFGVG-PASFGAELELYIIDKQGRP-SAKNQEILAAVND----PNLTLELNRFNLEYNL 89 Query: 64 DVC----RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERY 116 + + Q ++ + + A H + G P + + D+ RY Sbjct: 90 EPTPASGASFSALQRQIDSVLRTLQGHAASHEASLLPIGILPTLKSEDMGPDAITDSPRY 149 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCASGDD---------------AIYLLHGLSR----- 156 Q ++ F H+ D + + ++ Sbjct: 150 QALARQLRE--KRGEDF----HISIKGRDTLDLYWQDVSLEGANTSFQFHYRVNPADFAD 203 Query: 157 -------FVPHFIALSAASPYMQGT----DTRFA------------------SSRPNIFS 187 P +AL+A SP G +TR A +R + Sbjct: 204 AFNAAQLVTPLAVALAANSPLFLGRRLWHETRVALFKQATDYRIETPLRLRLPARVLFGN 263 Query: 188 AFPDNGPMPWV-SNWQQFEALFRCLSYTTMID------------SIKDLH-WDIRP---S 230 + FE L + + W+ RP Sbjct: 264 GWVRKDAHEVFCEGVSLFEPLLPICGDGAALRPGQAPPLDELRLHQGSIWAWN-RPIYDP 322 Query: 231 PHFGTVEVRVMDTPLTLSHAVNMA--GLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC 288 G + + + P S +A L L + ++N ++A Sbjct: 323 ADGGHIRIEIRALPAGPSTTDMLANAALTVGLIEGLRPAMHDMLPAIPFRYCEYNFYRAA 382 Query: 289 RYGLEGVITDPHTG----DRRPLTEDTLRLLEKIAPSAHKI-----GASSAIEALHRQVV 339 +YGL + P G RP+ + +L H + ++ + Sbjct: 383 KYGLRAKLFWPGQGGAGLQERPVLDILEDMLPVAEQGLHALAIAPTDVRHYLDVCAENLA 442 Query: 340 SGLNEAQLMRDFVAD 354 +N A + Sbjct: 443 QPVNGALWQLRMLER 457 >UniRef50_A1K6A6 Glutamate-cysteine ligase n=5 Tax=Proteobacteria RepID=A1K6A6_AZOSB Length = 423 Score = 75.6 bits (185), Expect = 3e-12, Method: Composition-based stats. Identities = 59/399 (14%), Positives = 121/399 (30%), Gaps = 52/399 (13%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKH------DITESMLEL-ATDVCR 67 G+E+E +V+ D+ + L+ A + A V+ ++ + E+ Sbjct: 17 GLEIEYMIVDRLHLDVKPIADRLLYAGAGEAVADVVRGEMGWSNELALHVFEIKNRAPSP 76 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEVCDNER------YQRTL 120 + F + + + GG HP+ + + +R Y R Sbjct: 77 TLAPLVDAFHREVRAAAELLAGMDARLMPGGMHPWMEPSTETRLWTQDRAALYACYDRIF 136 Query: 121 E--NFGYLIQQATVFGQHVHVGCA--SGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 + G+ Q+ VH+ ++ L + +P AL+A+SP+ + Sbjct: 137 DCRRHGWGNLQS------VHLNLPFSGDEEFGRLHAAVRLALPILPALAASSPWADKRPS 190 Query: 177 RFASSRPNIF---SAF-P-DNG--PMPWVSNWQQFEALF-----------RCLSYTTMID 218 +R ++ P G ++ + AL + Sbjct: 191 GVLDTRLLMYRDHQRLVPASMGDCIPEPIATAADYHALVLAPMYRQVAEYGAVRCKGDAS 250 Query: 219 SIKDLHWDIRPS-PHF--GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQE- 274 ++ + R + P F +E+RV+DT V +A L R Sbjct: 251 ELRHEWLNARAAVPRFERSAIEIRVLDTQECPLADVAVAAASAGLVRHLYDHRCANADAL 310 Query: 275 KDYLLYKFNRFQACRYGLEGVITDP----HTGDRRPLTEDTLRLLEKIAPSAHKIGAS-S 329 D + + R + I P G L ++ G + Sbjct: 311 VDTPVLVDIFERCIRDADQARIEHPDYLALFGLGNGGGLSAGELWGRLLDRLDASGQLPA 370 Query: 330 AIEALHRQVVSGLNEAQLMRDFVADG-GSLIGLVKKHCE 367 + + + A+ + + D G L + + CE Sbjct: 371 PLHPPLQLFLQRGPLARRLASALDDDPGRLRAVYGELCE 409 >UniRef50_C0W6H8 Putative uncharacterized protein n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W6H8_9ACTO Length = 129 Score = 75.6 bits (185), Expect = 3e-12, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 47/97 (48%), Gaps = 1/97 (1%) Query: 276 DYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALH 335 N++++ RYG++ ++ G+ +++ +++E++ P A ++G + A+ Sbjct: 2 PDWYVDENKWRSARYGMDAILITGSDGEEELVSDTVAQMVEQLMPVAEELGCVRELVAIQ 61 Query: 336 RQVVSGLNEAQLMRDFVADGGSLIGLVKKH-CEIWAG 371 + +G + + + A GG+ VK E+ AG Sbjct: 62 TTLDAGASYQRQLAAVSAAGGANQAAVKLMQAEVRAG 98 >UniRef50_C8NRE4 Family 2 glutamate-cysteine ligase n=11 Tax=Actinomycetales RepID=C8NRE4_COREF Length = 495 Score = 74.9 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 62/427 (14%), Positives = 121/427 (28%), Gaps = 100/427 (23%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV----CRD 68 ++G+ELE+ +V+ + + +L + GE + +I +EL Sbjct: 43 SIGLELELNLVDADMQPALRGAEVL------RHLDGEFQSEIGNYNVELNHPPLSAKHDG 96 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ----RQEVCDNERYQRTL---- 120 + + + V +AAT + + GT P + + RY+ Sbjct: 97 LQRLQDGITNRLNRVHEAATTEGVNVAMIGTLPTITPEFLADPAWMTQENRYRALSNAVM 156 Query: 121 ------------------ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 ++F + ++T +H+ A A + + Sbjct: 157 ESRGELVHINLADREHVNQSFHDIAPESTCTSMQLHLQLAPTRFA-AAWNASQAIAGAQV 215 Query: 163 ALSAASPYMQGTDTRFAS--------------------SRPNIF--SAFPDNGPMPWVSN 200 ALSA SP G S RP ++ + + Sbjct: 216 ALSANSPLFLGRRVWHESRIPVFKQAIDTRTSELVNQGVRPRVWFGERWITS----VFDL 271 Query: 201 WQQFEALF-------RCLSYTTMI-----------DSIKDLH-WDIRP---------SPH 232 +++ F R L+ T M+ + W+ RP Sbjct: 272 FEENVRYFSPLIAEDRALAGTPMMKGKSPALHYLNLHNGTIWRWN-RPIYAPGEERSHLR 330 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 +E R++ T + V A +L+ E + + N R GL Sbjct: 331 ---LENRLLPAGPTPADIVADAAFYYGVVKYLVEENRPVWSRLTFADAERNFQSGARSGL 387 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEA-----LHRQVVSGLNEAQL 347 +T P G LL + ++ +I + + + N A Sbjct: 388 FARMTWPRLGQVNATDLIVEHLLPQAREGLRRLEVDDSIAEHYLGIIDERARTRQNGATW 447 Query: 348 MRDFVAD 354 + Sbjct: 448 QLRTLNK 454 >UniRef50_Q9JMV4 Putative glutathione synthetase GshA (Fragment) n=3 Tax=Bacteria RepID=Q9JMV4_BRAJA Length = 460 Score = 74.9 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 51/160 (31%), Gaps = 8/160 (5%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ +++Q + A V + A + G G P V RY+ Sbjct: 73 QFELSGAPVENVHQTQSELMAHLAQVREIAAPLGIGFLGLGMTPSWSRADIPVMPKGRYK 132 Query: 118 RTLENFGYLIQQAT-----VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 + Q ++ +S D + L L P AL A SP+ + Sbjct: 133 IMTNYMPKVGQYGLDMMYRTCTVQTNLDFSSEADMVKKLRVLLALQPVATALFANSPFTE 192 Query: 173 GTDTRFASSRPNIFSAF--PDNGPMPW-VSNWQQFEALFR 209 G F S R I+ G MPW + FE Sbjct: 193 GKPNGFLSFRSEIWRDTDNARAGMMPWAFEDGMGFERYVD 232 >UniRef50_A0M1L9 GCS2 glutamate--cysteine ligase n=3 Tax=Flavobacteriaceae RepID=A0M1L9_GRAFK Length = 406 Score = 73.7 bits (180), Expect = 1e-11, Method: Composition-based stats. Identities = 48/286 (16%), Positives = 89/286 (31%), Gaps = 57/286 (19%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELAT-DVC 66 GIELE +V + ++ L IT+ E +++ ++E+ T Sbjct: 9 FGIELEYMLVKRSNFKVNPIVDQLFIEKHGSITSDTENGKIEWSNELVAHVVEMKTNGPT 68 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF--- 123 D+ F+ + + + + +HP Q + Y + + Sbjct: 69 NDLLDLDSLFAENVREMNKHLQKFDTFLLPSASHPLMNPQTETKLWEHHYNKIYSLYNKI 128 Query: 124 ------GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 G+ + V H+++ + L + +P LSA+SP + G T Sbjct: 129 FNCKGHGW----SNVQSMHINLPFFDDAEFEKLHAAVRILLPIIPGLSASSPVLDGKFTG 184 Query: 178 FASSRPNIF----SAFPD-NG--PMPWVSNWQQFEALF-------------------RCL 211 F SR + P G V N + L Sbjct: 185 FKDSRMEFYKSNQKEIPHMTGKIIPEQVFNKADYNKTIFEPIINAIKPFDTENILDHHFL 244 Query: 212 SYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 + I +D R + +E+RV+D S + +A I Sbjct: 245 NSRGAIS-----RFD-RNA-----IEIRVIDIQENPSADIAIAAFI 279 >UniRef50_D0LNP6 CBS domain containing membrane protein n=3 Tax=Myxococcales RepID=D0LNP6_HALO1 Length = 640 Score = 73.7 bits (180), Expect = 1e-11, Method: Composition-based stats. Identities = 58/434 (13%), Positives = 121/434 (27%), Gaps = 98/434 (22%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE--LATDV 65 + +G E EM +V+ + ++ + ++ + ++ +E + V Sbjct: 38 ETGRRRIGAEQEMFLVDRAMRP-CPAAMEILTGIDDE----RITTELARFNIEANINAQV 92 Query: 66 CRD--INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRT- 119 + Q + + ++V +AA H E+ G P + + + RY+ Sbjct: 93 FGGNCLRQMETELGEVVELVRRAAEPHGAEVLLAGILPTLRKTDLGLENMTPSPRYESLN 152 Query: 120 -----------------LENFGYLIQQATVFGQ----HVHVGCASGDDAIYLLHGLSRFV 158 + + + VH + A + + Sbjct: 153 RALTQQRGGDFHIHIKGTDELQFTHDNVMLEACNTSFQVHFQVTPEEFA-RMYNVAQAVT 211 Query: 159 PHFIALSAASPYMQG----TDTRFASS------------------RPNIFSAFPDNGPMP 196 +A + SP G +TR A R + S + + Sbjct: 212 APVLAAAVNSPVFLGQRLWQETRVALFQLSVDERSATHQSRGFPPRVSFGSGWVRESVLE 271 Query: 197 WVSN---------WQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGT------------ 235 E + + +++ L H GT Sbjct: 272 IFREQIARFRILLAADLEEDSLAMLERGEVPTLRALR------VHNGTTYRWNRACYGIS 325 Query: 236 -------VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC 288 +E RV+ T++ V A L L P + + + N F+A Sbjct: 326 EGIAHLRIENRVLPAGPTVADEVANAALYFGLMSAFLEAYPDISKVMAFDDARMNFFEAA 385 Query: 289 RYGLEGVITDPHTGDRRPLTEDT-LRLLEKIAPSAHKIG-ASSAIEA----LHRQVVSGL 342 R+GL+ T+ LL S+ I+ + ++ S Sbjct: 386 RHGLKAQF-HWVGDKVYSATDLLTSHLLPMARKGLQNADIDSADIDRYIGIMEERIKSRR 444 Query: 343 NEAQLMRDFVADGG 356 AQ + +++ G Sbjct: 445 TGAQWVLRSLSEMG 458 >UniRef50_C4GD43 Glutamate--cysteine ligase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GD43_9FIRM Length = 418 Score = 73.3 bits (179), Expect = 1e-11, Method: Composition-based stats. Identities = 77/428 (17%), Positives = 134/428 (31%), Gaps = 84/428 (19%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F G+E E Q V P G+ L + D ES LE+ T Sbjct: 9 PTFTQGG---FGLEEENQRVTPEGF--------LAQTDHPFGDDPVLDRDFCESQLEIIT 57 Query: 64 DVCRDINQAAGQFSAMQKVVLQ-AATDHHLEICGGGTHPFQKWQRQEVCDNER------- 115 V + + ++ V + A + E+ PF + R Sbjct: 58 GVHHNPRELVKALGDKRREVARFLAGQNTPELLW----PFSNPPCLRSEKDIRIAQFVGE 113 Query: 116 ------YQ-RTLENFGYLIQQATVFGQHVHVGCAS------GDDAIY-------LLHGLS 155 Y+ +G ++ ++ G H + ++ + L L Sbjct: 114 KAEKTVYRNYLAGKYGR--KKQSLCGIHFNFSYPQAFLDCLREEGVSADQIYLNLAEKLL 171 Query: 156 RFVPHFIALSAASPYMQGTDTR----------FASSRPNIFSAFPDNGPMPWVSNWQQFE 205 + +AL+AASP M + ++S R + + + P+ + Sbjct: 172 AYSWLIVALTAASPLMDASFEGGKPGEILAGIYSSYRCSDRGYWNEFEPVLDFDAIPNYL 231 Query: 206 ALFRCLSYTTMIDSIKDLHWDIRPSPHFGT------------VEVRVMDTPLTLSHAVNM 253 T + S +L++ +R P GT +E+R++D ++ Sbjct: 232 DSMNYYVETGKLYSAAELYYPVRLKPK-GTNALDKLREGVNHIELRMLDINPLRDEGIDP 290 Query: 254 AGLIQATAHWLLTERPFKHQEKDYLLYKF-----NRFQACRYGLEGVITDPHTGDRRPLT 308 + LL + D + + N QA Y LE V G PL Sbjct: 291 S---DLEFLTLLLLYLTARPKMDLSVMRQRRAMRNMKQAASYPLEKVSLFWTDGQMHPLP 347 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLN-EAQLMRDFVAD---GGSLIGLVKK 364 E L +L + +GA AI ++ A + D + GG L ++ Sbjct: 348 ELALEILADMENV---LGAHEAISRQIDKIKDPDRCYASQILDRYGEDYIGGGLAR-ARE 403 Query: 365 HCEIWAGD 372 I GD Sbjct: 404 LAGISEGD 411 >UniRef50_D2RUA3 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RUA3_9EURY Length = 363 Score = 72.5 bits (177), Expect = 2e-11, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 97/275 (35%), Gaps = 39/275 (14%) Query: 17 ELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQF 76 E+E V++ G +S S L+D + ++ + E MLE+ T C + + +F Sbjct: 6 EVEYWVIDDDGDLVSPGS--LLD------YSEQIDPEFVEPMLEIKTTPCSSMAELREEF 57 Query: 77 SAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF-GYLIQQATVF-G 134 + + ++ AA + + T D R G A V G Sbjct: 58 LGLIEEIVDAARERDKRLVPLATPLHAAPSEIPYRDK-RGTDLQRRIVGPAFDDARVCAG 116 Query: 135 QHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA-----F 189 H+H ++ D + +L L P F AL +S + +G +RP ++ Sbjct: 117 THMHFEQSNVADQLNMLTALD---PAF-ALVNSSSHYRGEHI-LECARPFLYRRSCYEPC 171 Query: 190 PDNGPM-PWVSNWQQFEALFRCL------------SYTTMIDS----IKDLHWDIRPSPH 232 PD G + P+V + ++E + D + ++ Sbjct: 172 PDQGQLWPYVDSAAEWEEELETAYDCFRERALERGVDSAAFDDEFAPYDAVWTPVQLRKA 231 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTE 267 TVE R DT L S + +A +++ Sbjct: 232 MPTVEWRSPDTAL-PSQVLRLAETVRSLVSRADAR 265 >UniRef50_A8M1F4 Glutamate--cysteine ligase GCS2 n=2 Tax=Salinispora RepID=A8M1F4_SALAI Length = 411 Score = 72.5 bits (177), Expect = 2e-11, Method: Composition-based stats. Identities = 58/354 (16%), Positives = 104/354 (29%), Gaps = 76/354 (21%) Query: 6 FHVSEPFTLGIELEMQV---VNPPG-----------YDLSQDSSMLIDAVKNKITAGEVK 51 F P LG ELE V V+P S + + + V Sbjct: 28 FKTGPPRWLGTELEWIVHDAVDPARPVGASRLRAALGPHSPRTLDITSPAQPLRYGSSVT 87 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E++T + A + L + GG + + Sbjct: 88 VE-PGGQVEVSTATHTSVAALVAATKAEIAQLTALLGRAGLVLGAGGI--DAHRSPRPMF 144 Query: 112 DNERY---QRTLENFGYLIQQAT--VFGQHVHVGCASGD---DAIYLLHGLSRFVPHFIA 163 + RY +R + G ++ G + + D D H + P +A Sbjct: 145 ETPRYRAMRRVFDRRGPAGRRMMYSTAGLQICLDVGEADQLADRWATAHAIG---PPLLA 201 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAF----------PDNGPMPWVSNWQQF--------- 204 A + G T + S+R + A P+ +++W ++ Sbjct: 202 AFATAGRHAGRPTGWVSARMAAWLAIDPARTRAVWTPEQDDTDPIASWTEYVLAAPLLCL 261 Query: 205 ----------------EALFRCLSYTTMIDS----IKDLHWDIRPSPHFGTVEVRVMDTP 244 + L L ID + L +RP G +E+R +D Sbjct: 262 RGGGSDWTTPDGVTFADWLAGALPQPPTIDDLDYHVSTLFPPVRPR---GYLELRYLDAQ 318 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF-QACRYGLEGVIT 297 S +V +A LL+E + + + R+ A R+GL Sbjct: 319 PGESWSVPVA-----VVAALLSEPAITRAARSLVGAQAQRWIAAARHGLRDDGL 367 >UniRef50_C7MXH6 Gamma-glutamylcysteine synthetase n=2 Tax=Actinomycetales RepID=C7MXH6_SACVD Length = 428 Score = 72.2 bits (176), Expect = 3e-11, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 57/201 (28%), Gaps = 26/201 (12%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV--KHDITES------ 57 F P LG+ELE V + L + L DA+ V + Sbjct: 47 FKHGPPRLLGVELEYTVHDAVDPGLPLSRTRLADALGPYAPRTLVPDSPEQPLPAGSTFT 106 Query: 58 -----MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCD 112 E++T A V L + G PF+ +R Sbjct: 107 LEPGGQAEISTAPHSSFRALCEAADADLAYVADLLAATGLRLGSRGIDPFRPPKRLLHT- 165 Query: 113 NERYQRTLENF-----GYLIQQATVFGQHVHVGCASGDD---AIYLLHGLSRFVPHFIAL 164 RY F G + + V V + H L P +AL Sbjct: 166 -PRYAAMERRFAPAGTGGITMMCSTAALQVCVDTGQPHELPHRWAAAHALG---PVLLAL 221 Query: 165 SAASPYMQGTDTRFASSRPNI 185 A S + G DT AS+R Sbjct: 222 FANSRWHAGVDTGCASARWLA 242 >UniRef50_C6XGY1 Glutamate--cysteine ligase n=2 Tax=Rhizobiaceae RepID=C6XGY1_LIBAP Length = 457 Score = 72.2 bits (176), Expect = 3e-11, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 81/274 (29%), Gaps = 51/274 (18%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 LEL+T ++++Q G+ +++ + + L I G G +P K + RY Sbjct: 99 QLELSTTTLQNVHQIKGEILGYIQILKEITQNLDLGILGMGFNPKWKLDEMPIMPKSRYV 158 Query: 118 RTLENFGYLIQQAT-----VFGQHVHVGCA---SGDDAIYLLHGLSRFVPHFIALSAASP 169 + + V + + + + L P A+ A+SP Sbjct: 159 LMKKYMPQVGTHGLDMMFRTCTTQVSLDFSSEHDMATKLRVSFKLQ---PLATAIFASSP 215 Query: 170 YMQGTDTRFASSRPNIFSAF---PDNGPMPWVSNWQQFEALFRCLSYTTM--IDSIKDLH 224 + +G F S R I+ + + FE + M I K+ + Sbjct: 216 FAEGRINGFQSWRSEIWRHTDSDRTEILPFILRDNSNFEHYAQWALDIPMYFILRKKEYY 275 Query: 225 ----------------------------WDIRPSPHFGTV------EVRVMDTPLTLSHA 250 W+ S F V E+R D+ L + Sbjct: 276 CCTDITFRQFMNGALKGRIKEWHPTLEDWENHLSTLFPAVRLRNCLEMRGADS-GRLENI 334 Query: 251 VNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR 284 +A + + H + Y N+ Sbjct: 335 FAVAAFWTGILYDSSALQNADHLTSSWSFYDINK 368 >UniRef50_C8XBM8 Glutamate/cysteine ligase family protein n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8XBM8_NAKMY Length = 445 Score = 71.8 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 71/406 (17%), Positives = 111/406 (27%), Gaps = 74/406 (18%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLS-----QDSSMLIDAV--------KNKITA 47 +P F P +G+ELE V L+ + LID + Sbjct: 31 IPRTFFKNGPPHRVGLELEFLVAGTGDDALATHYPHEQYPHLIDRLIDGPPDSPPGGGLD 90 Query: 48 GEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 G V + +EL++ + + + A + G G P Sbjct: 91 GRVTVE-PGGQVELSSRPGDSLAATVDTVHHDLARLRRRARGRGARLVGLGVDPI--RPP 147 Query: 108 QEVCDNERYQRTLENFGYLIQQ---ATVFGQHVHVGCASGDDAIYLLHG---LSRFVPHF 161 + + D RY+ F V V + A+ L L P Sbjct: 148 RRITDQPRYRAMERYFRPWGATGPAMMCSTASVQVNVEAATPAVDLHRRWELLHAIGPTL 207 Query: 162 IALSAASPYMQGTDTRFASSRPNIFSAF-P-DNGPMPWVSNWQQFEALFRCLSYTTMI-- 217 +A A SP G T F S+R I+ P G P A R ++ Sbjct: 208 VAAFANSPRRLGRATGFQSTRQAIWQELDPARTGAPPRAPGEDPATAFTRWSLDAPVMLI 267 Query: 218 ----------DSIKDLHW---------DIRPSP-------HFGT----------VEVRVM 241 + W D RP+P H T +E+R + Sbjct: 268 RREHDDWSAPPELSMRSWIRHGRRAVPD-RPAPTVDDLAYHLSTLFPPVRPRGHLEIRYL 326 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPH 300 D V A + ++ E ++ A R G+ DP Sbjct: 327 DALPGCWWIVPAAVIAALLDDPAAADQARATCEPVQE-----HWRTAARSGVR----DPA 377 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 G T + P+A + L R + G + A Sbjct: 378 LGRAATALLTTAAQALRRDPTAARFADPVE-GYLQRWTLRGRSPAD 422 >UniRef50_A7I8T0 Glutamate--cysteine ligase, GCS2 n=6 Tax=Euryarchaeota RepID=A7I8T0_METB6 Length = 370 Score = 71.8 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 59/394 (14%), Positives = 131/394 (33%), Gaps = 63/394 (15%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELATD- 64 T+G E E + + L S +I A+ + + + ++ +S++E Sbjct: 1 MTVGTEHEYSINDAHFTAL-PVSDQIIKAICGRFESEIRFGEVNLGKELQKSVIEFVPRT 59 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN------ERYQR 118 Q + + + + G G HP R V D+ E Y R Sbjct: 60 PASGPAALEAQIFSGIEKFYRVFPAR-YHLLGLGMHPTLTLDRAIVWDHDEGEYYEAYDR 118 Query: 119 T--LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 + G+L + +++ A D + + + +P+ IALSA+SP ++G T Sbjct: 119 LFNIRQHGWL----NIQALQINLSYAGEKDLLVQYNRIRTLLPYLIALSASSPMVEGRLT 174 Query: 177 RFASSRPNIFS----AFP--DNG-PMPWVSNWQQF----EALFRCLSYTTM-------ID 218 +R + P +G +S+ ++ E ++ L ++ Sbjct: 175 GAMDNRLLFYRENQKEIPGICSGIIPARLSSVAEYKSAQEVIYTELRERDAAILCEEWLN 234 Query: 219 SIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYL 278 S + IR S +E++ +D + + + + T P + + L Sbjct: 235 SSGLI---IRFSRQC--LEIKALDEQECVRSDMAFVAFVSSLLRC--TTLPVESDQDSLL 287 Query: 279 LYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQV 338 A R G G++ P E +A + + + ++ Sbjct: 288 ALTE---TAIRQGTAGLL---------PELEALYS-HAWRKATAEE---RQYLPVIKERI 331 Query: 339 VSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 G + A+ + + ++ ++ + + Sbjct: 332 AKG-SLAEQIAERYRKEQAIEPVLADLAQCLRAN 364 >UniRef50_Q5FPI3 Glutamate--cysteine ligase n=1 Tax=Gluconobacter oxydans RepID=Q5FPI3_GLUOX Length = 486 Score = 71.4 bits (174), Expect = 6e-11, Method: Composition-based stats. Identities = 55/342 (16%), Positives = 96/342 (28%), Gaps = 66/342 (19%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ I + + A V A + L G P RY Sbjct: 135 QFELSGAPVVSIQETEAEMQAHFDQVRGPAAELGLGFLPFGFQPLWPRDAMPWMPKSRYA 194 Query: 118 RTLENF---GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFV---PHFIALSAASPYM 171 G L V V D+A + + + P AL A SP++ Sbjct: 195 IMRNYMPKVGSLGLDMMTRTCTVQVNLDFSDEA-DMARKMRVSLALQPVATALFANSPFV 253 Query: 172 QGTDTRFASSRPNIF----SAFPDNGPMP-WVSNWQQFEALFRCLSY------------- 213 +G S+R I+ + +G + + FE Sbjct: 254 EGKANGLLSNRARIWTDTDNQ--RSGQPSVFFEDGFGFEQYVDWALDVPMYFVSRDGKNI 311 Query: 214 -----------TTMI---------------DSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 + D + + D+R +E+R D L Sbjct: 312 DVAGCSFRRWLAGDVQEPLKGLTPTVGDFEDHLTTVFPDVRLKQF---LEMRGADA-GKL 367 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC--RYGLEGVITDPHTGDRR 305 V + L + T + ++ + + +A R GL+ G + Sbjct: 368 EMMVAQSALWVGLLYDPATLEAAEKLVREQPWSVYQQLRAEVPRLGLDAAFP----GGLK 423 Query: 306 PLTEDTLRLLEK-IAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 P + + L E+ + A + ++ LH G N+AQ Sbjct: 424 PFAKRVVELAEQGLR--ARVRNEAGYLDPLHLIADGGPNQAQ 463 >UniRef50_P46309 Glutamate--cysteine ligase, chloroplastic n=133 Tax=cellular organisms RepID=GSH1_ARATH Length = 522 Score = 70.6 bits (172), Expect = 9e-11, Method: Composition-based stats. Identities = 52/368 (14%), Positives = 101/368 (27%), Gaps = 78/368 (21%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ ++Q + ++ V A + + G G P + + + RY Sbjct: 171 QFELSGAPLETLHQTCAEVNSHLYQVKAVAEEMGIGFLGIGFQPKWRREDIPIMPKGRYD 230 Query: 118 RTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 G L V++ +S D I P AL A SP+ + Sbjct: 231 IMRNYMPKVGTLGLDMMLRTCTVQVNLDFSSEADMIRKFRAGLALQPIATALFANSPFTE 290 Query: 173 GTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTM---------IDSI 220 G F S R +I++ G + FE M ID Sbjct: 291 GKPNGFLSMRSHIWTDTDKDRTGMLPFVFDDSFGFEQYVDYALDVPMYFAYRKNKYIDCT 350 Query: 221 KDLH--------------------W---------DIRPSPHFGTVEVRVMDTPLTLSHAV 251 W ++R + +E+R D Sbjct: 351 GMTFRQFLAGKLPCLPGELPSYNDWENHLTTIFPEVRLK-RY--LEMRGADGGP-WRRLC 406 Query: 252 NMAGLIQATAH-----WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + + + + + + + N+ P TG + P Sbjct: 407 ALPAFWVGLLYDDDSLQAILDLTADWTPAEREMLR-NK-------------VPVTGLKTP 452 Query: 307 LTEDT-----LRLLEKIAPSAHKIGASSA--IEALHRQVVSGLNEAQLMRDFVAD--GGS 357 + +L+ + G A + A+ V +G+ A+ + + G S Sbjct: 453 FRDGLLKHVAEDVLKLAKDGLERRGYKEAGFLNAVDEVVRTGVTPAEKLLEMYNGEWGQS 512 Query: 358 LIGLVKKH 365 + + ++ Sbjct: 513 VDPVFEEL 520 >UniRef50_A6GCK2 Glutamate--cysteine ligase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GCK2_9DELT Length = 468 Score = 70.2 bits (171), Expect = 1e-10, Method: Composition-based stats. Identities = 56/343 (16%), Positives = 92/343 (26%), Gaps = 67/343 (19%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ ++ +FS + A + G HPF +V RY Sbjct: 106 QFELSGAPLPTVHDTCAEFSTHYDELHAVAEPMGVAWIASGFHPFATRGEIDVMPKGRYA 165 Query: 118 RTLENF---GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFV---PHFIALSAASPYM 171 G V D+A L + AL A SPY+ Sbjct: 166 VMKSYLPTKGERALDMMFRTCTVQANFDYRDEA-QCGLRLRMIMGISGLITALFANSPYV 224 Query: 172 QGTDTRFASSRPNIFSAF-P-DNG-PMPWVS---NWQQFEAL------------------ 207 +G S R + P G +WQ++ Sbjct: 225 EGEHRGTRSMRSATWEHVDPDRCGLLPFVFEPDFSWQRYVDWALDVPMFFVYRGGRYNAH 284 Query: 208 ---FRCLSYTTMIDSIKDLH------WDIRPSPHFGTV------EVRVMDTPLTLSHAVN 252 FR D H W++ S F V E+R D+ + Sbjct: 285 HVPFRRFLAEGYTDEAGTTHRATQADWELHLSTLFPEVRIKPFIEIRGADSVGS-KTVCA 343 Query: 253 MAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACR-YGLEGVITDPHTGDRRPLTED 310 + L + E ++ + + ++ R GL DP + + Sbjct: 344 LPALCKGILYDDDAREGAWELVANLDFAGRMDLWKRGRTDGLS----DPE------VLDK 393 Query: 311 TLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEA 345 +LL ++ + ++AL QV G A Sbjct: 394 CRKLLTLARGGLERLDVRDSKGRTEARFLDALDAQVERGATPA 436 >UniRef50_B2HGM5 Putative uncharacterized protein n=3 Tax=Mycobacterium RepID=B2HGM5_MYCMM Length = 499 Score = 70.2 bits (171), Expect = 1e-10, Method: Composition-based stats. Identities = 63/447 (14%), Positives = 128/447 (28%), Gaps = 97/447 (21%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T+G+E+E+ +V+P G + DAV + +++H++ + +EL Sbjct: 52 TIGMEVELDLVDPLGRPRL-----VNDAVLQALDRTDMQHELGQFNVELNLPPHPLTGHV 106 Query: 73 AGQFSAMQKVVLQAATDH----HLEICGGGTHPF---QKWQRQEVCDNERYQRTLENFG- 124 + VL + + G P + + N RY+ Sbjct: 107 LRDSEQLLADVLDGSGARIESLGTRLIAVGMLPTLSADHMTAERLSTNPRYELLSRRIRT 166 Query: 125 ----------------------YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 + +A+ +H+ A D + + Sbjct: 167 ARHRPFRVHISDAPEPVEFTTDSVAPEASATSLQLHLR-AHRDRFAAYFNAAQLIAGAQV 225 Query: 163 ALSAASPYMQGT---------------DTRFAS-------SRPNIFSAFPDNGP------ 194 A++A SP++ G D+R S +R + + + Sbjct: 226 AVAANSPFLLGRHAWQETRITLVEQLLDSRRPSEVKASAPARVRLGEGWISDPVDLFDHL 285 Query: 195 ----MPWVSNWQQFEALFRCLSYTTMIDSI-----KDLHWDIRP-------SPHFGTVEV 238 P + + + + + RP SP +E Sbjct: 286 VREYPPLFPTLEAEDPDAALEAGQAPVLHELRLHNGTVWQWNRPVYDVQGGSPQLR-IEN 344 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 RV+ + T V A + ++ + + + + +A R GL + Sbjct: 345 RVLPSGPTAVDMVANAAFYYGLVRAIADSDRTPWEQTPFAVAERDLHRAARDGLAAQL-- 402 Query: 299 PHTGDRRPLTEDTLR-LLEKIAPSAHKIGASS-----AIEALHRQVVSGLNEAQLM---- 348 G +P + T LL A G + + + +V SG A Sbjct: 403 SWQGTDQPAAQLTRDVLLPAAASGLDAWGVDAHDRDRYLGVIEARVRSGRTGAAWQTETV 462 Query: 349 RDFVADG----GSLIGLVKKHCEIWAG 371 R G +L + +++ E Sbjct: 463 RHLEERGLERISALHEMTRRYVEHARS 489 >UniRef50_C8WKE9 Glutamate--cysteine ligase n=2 Tax=Coriobacteriaceae RepID=C8WKE9_EGGLE Length = 427 Score = 69.9 bits (170), Expect = 1e-10, Method: Composition-based stats. Identities = 56/401 (13%), Positives = 119/401 (29%), Gaps = 72/401 (17%) Query: 9 SEPFTLGIELEMQVVN----PPGYDLSQDSSMLIDAVKNKIT----------------AG 48 P LGIELE +V+ P Y + ++ + + Sbjct: 33 GGPGELGIELEQIIVHDDLSPVSYSGEHGVAWVLRQLAADYPRTTTDEHGDLLGVARPSE 92 Query: 49 EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 V + + +EL+ D+ A F + + + G HP + Sbjct: 93 AVTIE-PAAQIELSAGPFADLATARDTFEGFAQRLSDVLEPAGEKALAIGYHPSATARSL 151 Query: 109 EVCDNERYQRT------LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 E+ RYQ + +G + + + V + S D + L VP Sbjct: 152 ELIPKRRYQFMDLYLGERDIYGPCMMRGS-ASTQVSIDYTSTADCLRKLRLAFALVPMLS 210 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAF--PDNGPMPWVSNWQ----QFEALF-------- 208 + +P +G R +I+ G +P V + ++ Sbjct: 211 LMCDNAPVFEGKPREHQLVRTDIWQHVDNDRCGLVPDVLDPSFDLRRYAEYILDTVAILI 270 Query: 209 --------------------RCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLS 248 R ++ + ++ D+R + +E+R D + Sbjct: 271 PCQQQRWCYSDRTFGDIYAARTMTRAEVEHAVSMFFTDVRLKTY---IEIRPADAMP-IP 326 Query: 249 HAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + + A LI+ + + + + + A + L + RP+ Sbjct: 327 YVIAYAALIKGL---FYAPTSLDAMDGLFADVRRDDYLAAQDALMERGYEAEVYG-RPVA 382 Query: 309 EDTLRLLEKIAPSA--HKIGASSAIEALHRQVVSGLNEAQL 347 E R+++ + G + L + V+ + A+ Sbjct: 383 ELCDRIVKIARDGLADEEQGFLEPLADLVARRVTLADLAER 423 >UniRef50_Q11LE8 Glutamate--cysteine ligase n=22 Tax=Alphaproteobacteria RepID=Q11LE8_MESSB Length = 457 Score = 69.9 bits (170), Expect = 2e-10, Method: Composition-based stats. Identities = 29/182 (15%), Positives = 50/182 (27%), Gaps = 21/182 (11%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ I+Q + +A + + A + G G P RY+ Sbjct: 99 QFELSGAPLETIHQTCREGNAHLAQLREIAEPLGIRFLGLGGSPKWTLAETPRMPKSRYE 158 Query: 118 RTLENFGYLIQQAT-----VFGQHVHVGC---ASGDDAIYLLHGLSRFVPHFIALSAASP 169 + V++ A + + L P AL A SP Sbjct: 159 IMTNYMPKVGSHGLDMMYRTCTIQVNLDFSSEADMRRKMQIGMRLQ---PLATALFANSP 215 Query: 170 YMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWD 226 + G + S R I+ +G S+ F +++ Sbjct: 216 FTDGAVNGYQSWRGEIWRDTDDQRSGLLPFVFSDQFGFADYVEWALDV-------PMYFV 268 Query: 227 IR 228 IR Sbjct: 269 IR 270 >UniRef50_B1MFR8 Glutamate--cysteine ligase GshA n=1 Tax=Mycobacterium abscessus ATCC 19977 RepID=B1MFR8_MYCA9 Length = 416 Score = 68.7 bits (167), Expect = 3e-10, Method: Composition-based stats. Identities = 58/354 (16%), Positives = 100/354 (28%), Gaps = 62/354 (17%) Query: 5 DFHVSEPFTLGIELEMQVVN---PPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 F ++ +G+ELE V P + D+V + + + + +EL Sbjct: 28 AFADAQVGAVGLELESHTVELTAPHRRITWNRLREVGDSVPDLPGSSAITFE-PGGAVEL 86 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 + C D+ A A +++ + + GT P ++ +R V RY Sbjct: 87 SGPPCSDVWSAISSMRADHEILTAVYRGAGIALASLGTDPLRRPER--VNPGARYVAMER 144 Query: 122 NFGY-----LIQQATVFGQHVHVGCASG-----DDAIYLLHGLSRFVPHFIALSAASPYM 171 +FG Q + V SG D L + P ALSA+SP + Sbjct: 145 HFGAAGYGETALQMMTCTASLQVNVQSGTPRQWRDRFVLAQRIG---PTMAALSASSPML 201 Query: 172 QGTDTRFASSRPNIFSAF-PD------NGPMPWVSNWQQFEALFRCLS-------YTTMI 217 G T ++R I+ P G P +W ++ + + Sbjct: 202 TGRPTGRRNTRQWIWDNLDPRRCAPVEIGVDPT-ESWVEYALRAPVMLVRNKDGADAVVT 260 Query: 218 DSIKDLHWD--IRPSPHFGT--------------------VEVRVMDTPLTLSHAVNMAG 255 D + + T +E+R +D Sbjct: 261 RVPFQSWVDGTMPLAGRAPTTEDLDYHLTTLFPPVRPRRWLELRYLDAAPD----WWWPA 316 Query: 256 LIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPLT 308 L L + + N + A R GLE Sbjct: 317 LAFTAVA-ALDDPQVADIAAEIAEPVGNAWGVAARIGLEDPALHAAAHRLVSAA 369 >UniRef50_D2RU12 Glutamate--cysteine ligase GCS2 n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RU12_9EURY Length = 365 Score = 67.5 bits (164), Expect = 7e-10, Method: Composition-based stats. Identities = 50/253 (19%), Positives = 80/253 (31%), Gaps = 38/253 (15%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQ 75 IE+E VV+ G + + V + + + E + EL T C I + Sbjct: 5 IEVEYWVVDTDGELTEPGA---LAEVSERT-----EREFVEPLFELKTPPCETIGELRAT 56 Query: 76 FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR--TLENFGYLIQQATVF 133 F+ + VL A + GT + + R Q+ E+F Y Sbjct: 57 FAEQLEEVLSTAAAEEKRLVPLGTPINCGAIDRRPSERGRIQKEVLGEDFAYA---KYCA 113 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD----TRFASSRPNIFSAF 189 G H+HV + D + L L + +SPY+ G R R + Sbjct: 114 GTHIHVEKRNVADQLNTLIALDAALALV----NSSPYLDGERVANSARAHCYRKKCYGDL 169 Query: 190 PDNGPMPWVSN---------WQQFEALFRCLSYTT----MIDS----IKDLHWDIRPSPH 232 P +G + + ++E R I+ + IR Sbjct: 170 PKHGQLWHYVDTVGEWCRRLEDRYEEFKRAALEEGIDEVAIEDNFSTDNVVWTPIRLRDE 229 Query: 233 FGTVEVRVMDTPL 245 TVE R D L Sbjct: 230 MPTVEWRSPDAAL 242 >UniRef50_C0N7Q3 Putative uncharacterized protein n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N7Q3_9GAMM Length = 475 Score = 67.5 bits (164), Expect = 8e-10, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 43/133 (32%), Gaps = 8/133 (6%) Query: 229 PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC 288 P VE R T+S + A +H + E + + N ++A Sbjct: 321 PHVR---VEHRTPAAGPTVSDMMANAAFYYGLSHAFCDRLIARGVELSFADARDNFYKAA 377 Query: 289 RYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASS-----AIEALHRQVVSGLN 343 RYGL+ I D + +R LL A K+ + + +V Sbjct: 378 RYGLDAHIVDLNGQHQRIQKYILDELLPLAAQGLDKLNIEDAEKQHYLSIIETRVEKHQT 437 Query: 344 EAQLMRDFVADGG 356 + R F+ G Sbjct: 438 GSDWQRAFINKHG 450 >UniRef50_D0I9T0 Putative uncharacterized protein n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0I9T0_VIBHO Length = 490 Score = 67.2 bits (163), Expect = 9e-10, Method: Composition-based stats. Identities = 64/429 (14%), Positives = 128/429 (29%), Gaps = 105/429 (24%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA---TDVCRDI 69 TLG ELE+ + + + + ++D + + + +I + +E T Sbjct: 44 TLGAELELYLTDKHHRP-AHCNLDILDKAADPL----MTPEINQFNVEYNCPYTGFHGSP 98 Query: 70 -NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERYQRT------ 119 + + A + + G P + + + + RYQ Sbjct: 99 FTFLKRNMDQKLQFLQGIARGDGINVIPIGILPTLRDGDFGPESMTNLPRYQALTDILRE 158 Query: 120 ------------LENFGYLIQQATVFGQ----HVHVGCASGDDAIYLLHGLSRFVPHFIA 163 LEN + T+ G VH + A + +G+ +A Sbjct: 159 SRGGPFHICIHGLENLQIEAEDVTLEGANTSFQVHYRVKPDEFAQW-YNGIQIATIFTLA 217 Query: 164 LSAASP---------------YMQGTDT------------------RF------------ 178 ++A SP + Q D+ + Sbjct: 218 IAANSPIFLQKKLWHETRVPLFKQSIDSRNLCGMSWHVPARVSYGKGYVRKSALELFRQG 277 Query: 179 ASSRPNIFSAFPDN----GPMPWVSNWQQFEALFRCLSYTTMID-SIKDLHWDIRPSPHF 233 S +P + P + G P + + ++ + D L ++R P Sbjct: 278 VSLQPVLLPDLPASTCKEGCGPILGALRLHQSTIWSWNRAVYDDADGGHLRIELRSLPAG 337 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE 293 T T+ N A L A+ L + K+N ++A +YG+ Sbjct: 338 PT----------TIDMVANAA-LCIGLAYALQENLDRLLDRLPFEFAKYNFYRAAQYGIH 386 Query: 294 GVIT--DPHTGDRR--PLTEDTLRLLEKIAPSAHKIG----ASSAI-EALHRQVVSGLNE 344 I TG + PL + +LL +A + K+G + + + ++ + Sbjct: 387 ADILWESSETGRLQEYPLVDVLAKLLPGVADALVKLGVARLEADMLMAVIEHRLAKRQSG 446 Query: 345 AQLMRDFVA 353 A +A Sbjct: 447 AVWQLKTLA 455 >UniRef50_A4CI62 CBS domain pair protein n=2 Tax=Flavobacteriales RepID=A4CI62_9FLAO Length = 621 Score = 67.2 bits (163), Expect = 1e-09, Method: Composition-based stats. Identities = 63/431 (14%), Positives = 128/431 (29%), Gaps = 109/431 (25%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD----I 69 +G E E +VN ++ S ++ ++ + ++T LE+ D R + Sbjct: 45 IGAEQEFCLVNAD-WEPSMNAPKILS----DLNEPHFTPELTRYNLEINLDPRRLQGTCL 99 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDNERYQRTLENFGY- 125 + Q + +AA H +I G P + + RY+ E + Sbjct: 100 SDMHNQLRDLLGRAQEAAARHGDKIILTGVLPTISTRHLGQAYMAPLNRYRILNEAVKHV 159 Query: 126 ----------------LIQQATVF-GQ----HVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 L + ++ G H+ +D + +++ Sbjct: 160 RDSDLEMHIKGVDEVNLHHDSIMYEGCNTSFQSHLQI-DPEDFSSAYNWAQAIAGPVLSV 218 Query: 165 SAASP---------------YMQGTDTRFASSRPN-------IFSAFPDNGPMPWV-SNW 201 A SP + Q DTR ++ R N S + + + Sbjct: 219 CANSPLLMGRELWEETRIALFSQSVDTRRSTFRLNEREPRVGFGSEWETGSAADFFKRSV 278 Query: 202 QQFEALFR-CLSYTTMIDSI---------------KDLH-WD--------IRPSPHFGTV 236 ++ +L + ++ + ++ W+ +P + Sbjct: 279 ARYRSLISTDFEASDSLEQVNRGQAPALTALSLYNGTVYPWNRLCYGRGGKKPHLR---I 335 Query: 237 EVR-VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLL----YKFNRFQACRYG 291 E R + P T N+A ++T RP + + + K N F A RYG Sbjct: 336 ENRYLPSGPTTADEIANLAFWT-----GIMTGRPSEFDDIRKKMDFRDAKKNFFHAARYG 390 Query: 292 LEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEA--------LHRQVVSGLN 343 + G P E LL+ P A++ + + L + + Sbjct: 391 MSAQF--RWQGKDVPAREL---LLDFFLPIAYRGLSRMQVAGADITKYLKLIENRIRSQS 445 Query: 344 EAQLMRDFVAD 354 A+ + Sbjct: 446 GAEWKIRTYRE 456 >UniRef50_A4RZD5 Gamma-glutamate cysteine synthase n=2 Tax=Viridiplantae RepID=A4RZD5_OSTLU Length = 484 Score = 66.8 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 56/392 (14%), Positives = 106/392 (27%), Gaps = 66/392 (16%) Query: 22 VVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQK 81 +V G+ ++ +I K+K V + EL+ ++ Q + + Sbjct: 93 LVERHGWTPINEADNIIGCTKDK---QSVTLE-PGGQFELSGAPLENLTQTDEEVRWHIE 148 Query: 82 VVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQH 136 V A + G G P + RY+ G Sbjct: 149 TVNALAREKGHRFLGIGFDPKWSVAEVPMMPKGRYKIMRAYMPKKGTRGHDMMFRTCTIQ 208 Query: 137 VHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF--PDNGP 194 V++ S D + P A+ A S ++ G DT + S R +++ G Sbjct: 209 VNLDFESEQDMVRKFRTSLALQPLATAMFANSAFVDGADTGYQSMRSDVWRDTDDDRTGT 268 Query: 195 MPW-VSNWQQFEALFR--------CLSYTTMIDSI-KDLH-------------------- 224 + W + FE + + + Sbjct: 269 LAWVFDDDFGFEKYCDYVMNVPMYFVYRNGTYVDVSGESWLDFMEGKLPQLPGDKPTIDD 328 Query: 225 WDIRPSPHFGTV------EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYL 278 W+ + F V E+R D + + + L L +++ E Sbjct: 329 WEQHLTTVFPEVRLKKYMEMRGADG-GSYEAIMALPALWVGL---LYSDKALDAAEAMVS 384 Query: 279 LYKFNRFQACR-----YGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHK--IGASSAI 331 + A R GL + +++E + +G + Sbjct: 385 DWTQVERDALRVDVTKDGLSAKF------RGGTANDIAKKMVELSVQGLQERGLGEEVYL 438 Query: 332 EALHRQVVSGLNEAQLMRDFVADG--GSLIGL 361 L V G + A M + A G L + Sbjct: 439 RYLQDIVDDGKSVAARMSEMNAREWNGDLEKV 470 >UniRef50_B5ZRA7 Glutamate/cysteine ligase n=8 Tax=Rhizobium RepID=B5ZRA7_RHILW Length = 457 Score = 66.8 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 46/136 (33%), Gaps = 7/136 (5%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ I++ + + + + A + G G P + RY+ Sbjct: 99 QFELSGAPLETIHETCRESNQHLATLREIAEPMGIRFLGIGGSPKWTYAETPQMPKSRYE 158 Query: 118 RTLENFGYLIQQAT-----VFGQHVHVGCASGDDAIYLLHGLSRFVPHF-IALSAASPYM 171 + Q V++ +S DD + +S + AL A+SP+ Sbjct: 159 IMTRYMPKVGSQGLDMMYRTCTIQVNLDFSSEDD-MRKKMRVSMKLQSLATALFASSPFT 217 Query: 172 QGTDTRFASSRPNIFS 187 +G S R +I+ Sbjct: 218 EGKPNGLLSWRGDIWR 233 >UniRef50_B4V5Z6 Glutamate-cysteine ligase n=10 Tax=Streptomyces RepID=B4V5Z6_9ACTO Length = 458 Score = 66.4 bits (161), Expect = 2e-09, Method: Composition-based stats. Identities = 64/406 (15%), Positives = 112/406 (27%), Gaps = 84/406 (20%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITES---MLELA 62 F P LG ELE V++ + + A A + +T LEL+ Sbjct: 53 FKTGPPRILGAELEWLVLDAE-RPGLPLAPERLTAAHEAAGALPLHSRLTVEPGGQLELS 111 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT--- 119 + ++ A V L + G G P + ++R + RY+ Sbjct: 112 SAPADSLSACVDGLQADLTAVRGVLHAQGLVLRGLGQDPRRPYRRLLT--DPRYEAMERY 169 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF-VPHFI-----ALSAASPYMQG 173 L+ G + V V +G + L R+ + H + A A SP + G Sbjct: 170 LDRAGPAGRAMMCASASVQVCVDAGHEEPGPLGHGRRWRLAHLLGAVLVAAFANSPAVDG 229 Query: 174 TDTRFASSRPNIFSAFPDN---GPMPWVSNWQQFEAL----------------------- 207 + +R ++ P + + Sbjct: 230 PYAGWRCARQGVWEDLDSGRSLAPPLDIEPRAAWTRHALDTRVMCVRAPEGAPEDTPWTV 289 Query: 208 -----FRCLSYTT---------MIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 FR T + + L +RP H +E+R++D + Sbjct: 290 PEGLTFRDWIRTGGPRPATAGDLEYHLTTLFPPVRPRGH---LELRMIDAQPGDDGWLVP 346 Query: 254 AGLIQAT------------AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 ++ A L + H L++ A R GL DP Sbjct: 347 VAVVHALFDDPEAAETAYRVSKALADSYGPHAAPRNPLWR----SAARAGLA----DPE- 397 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL 347 L A + ++GAS + + A Sbjct: 398 -----LRSAATACFLAAAEALPRLGASDLVRDTVAEFTERHVLAGR 438 >UniRef50_C7NI09 Putative uncharacterized protein n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NI09_KYTSD Length = 503 Score = 66.4 bits (161), Expect = 2e-09, Method: Composition-based stats. Identities = 62/443 (13%), Positives = 109/443 (24%), Gaps = 105/443 (23%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 +F + P +G+ELE+ +V+ + +L + + ++ +E+ Sbjct: 37 EFDATFP-KIGLELELNLVDEQMQPSMSNDDVL------EHLGDHFQSELARFNIEVNVA 89 Query: 65 V----CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDNERYQ 117 + AA + G P + + E + RY Sbjct: 90 PRPAATGASPSLEHVVLHHLQEAEDAAQQAACRMVPIGILPTLRPEHLEGEWISGGARYT 149 Query: 118 RTL---------------------ENFGY----LIQQATVFGQHVHVGCASGDDAIYLLH 152 E + A +H S + + Sbjct: 150 ALEKAILHERGGEGASLDIAGPGGERVQMYVPGIAPAAACTSLQLHRQV-SPEKFATFWN 208 Query: 153 GLSRFVPHFIALSAASPYMQGT---------------DT--------RFASSRPNIFSAF 189 +A A SP++ G DT AS R + Sbjct: 209 AAQLIAAVQVAAGANSPFLFGKRLWAETRIPLFEQVLDTRTPELRNQGVAS-RAIFGRDW 267 Query: 190 PD--------------NGPMPWVSNWQQFE---------------ALFRCLSYTTMIDSI 220 L R L + I Sbjct: 268 ISSPADLFRENIGSYPALLPELFEMPADEGGPKSATPGDRKGRAPELPRLLLHNGTIWRW 327 Query: 221 KDLHWDI---RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDY 277 +D+ P VE RVM T + + L L+ + P + Sbjct: 328 NRAIYDVVDGVPHLR---VENRVMPAGPTAADTLANCALYYGLLRTLVDQSPHPWVGVSH 384 Query: 278 LLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT-LRLLEKIAPSAHKIGASS-----AI 331 + N + A +GL+ + P P+TE LL G S + Sbjct: 385 DDAERNFYAAAEHGLDAELVWPGISGPLPVTELLTEHLLPLAHDGLLAGGTSRQDADTYL 444 Query: 332 EALHRQVVSGLNEAQLMRDFVAD 354 + R+ +G+N A V Sbjct: 445 GTIRRRCETGVNGAVWQTRAVEQ 467 >UniRef50_B4S4M7 Putative uncharacterized protein n=7 Tax=Chlorobiaceae RepID=B4S4M7_PROA2 Length = 494 Score = 66.4 bits (161), Expect = 2e-09, Method: Composition-based stats. Identities = 54/422 (12%), Positives = 121/422 (28%), Gaps = 93/422 (22%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA-- 72 G ELE +V+ + + + ++ V + + V +++ E+ + Sbjct: 60 GFELEGWLVD-SNCNPAASNEEFLEKVNHHL----VVPELSRYNFEINSTPHPPGGAMFR 114 Query: 73 --AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLEN----- 122 + +++ + A ++ G P ++ V +RY Sbjct: 115 LMHEELASIWEHCSAIAATIGVKPMMIGILPTIDNRQLCLDNVSPLQRYSALNREILRSR 174 Query: 123 -------------------FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 ++ +A +H + A+ + +A Sbjct: 175 QKKPLRIHIEGITETLDIVHHDVMAEAATTSLQIHFQTT-PNLAVRHYNAAHLLSAPMVA 233 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQ-----------QFEA------ 206 +A +PY+ G + ++ +R +F +P ++ + Sbjct: 234 STANAPYLFGKE-LWSETRIPLFEQ---AVSIPTFTDRHGNIISRVTFGRDYARHSLLEV 289 Query: 207 LFRCLSYTTMID----------------SIKDLH-WDIRP--------SPHFGTVEVRVM 241 L ++ + W+ RP PH +E RV Sbjct: 290 FLENLDAFPILLPVVFDEDPGWMNHVRLHNGTIWRWN-RPLIGMNKEGKPHLR-IEHRVP 347 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 ++ + + +LL+E+ + + N +QA RYGL+ Sbjct: 348 SAGPSIPDCIANIAFFYGSMLFLLSEKEPLSTMLSFEDIRHNFYQAARYGLDAR-IRWLN 406 Query: 302 GDRRPLTEDTLRLL------EKIAPSAHKIGASSAIEALHR-QVVSGLNEAQLMRDFVAD 354 G + E LL +A ++ + R +V A F+ Sbjct: 407 GRTMSVQELITTLLLPGAYSALLAADVDPDDVRLYLDGIIRPRVTEKKTGAHWQTAFIRR 466 Query: 355 GG 356 G Sbjct: 467 HG 468 >UniRef50_UPI00016C5767 glutamate--cysteine ligase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C5767 Length = 444 Score = 65.6 bits (159), Expect = 3e-09, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 70/234 (29%), Gaps = 28/234 (11%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLS---QDSSMLIDAV------KNKITAGEVKHDITES 57 + + +G E E ++ ++ A+ + AG + +T Sbjct: 29 KPTPAWRVGAEFEKFALDRGTGQQIGFDAGIEGVLHALATHFAWEPHTEAGRLTT-LTRG 87 Query: 58 ----------MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 LEL+T +++ +F + + G PF + Sbjct: 88 RSTVSVEPGGQLELSTAPTARLSELRAEFETHLHELRAVTDPAKVAWVAAGVTPFSAVED 147 Query: 108 QEVCDNERYQRTLENFG-----YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 + R++ E L V S DA L + P Sbjct: 148 IPLNPRPRHRLMAEYLPTRCPHGLHMMKATASTQVTFDYKSEADAGRKLAVALKLGPVVN 207 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAF-P-DNG-PMPWVSNWQQFEALFRCLSY 213 AL A +P G T F S R +I+ P +G +++ F+ + + Sbjct: 208 ALFANAPLYAGRRTEFVSFRGHIWHNMDPDRSGLLTDLLADEITFDRWVQFVLD 261 >UniRef50_B9ZBA6 Glutamate--cysteine ligase GCS2 n=1 Tax=Natrialba magadii ATCC 43099 RepID=B9ZBA6_NATMA Length = 358 Score = 65.6 bits (159), Expect = 3e-09, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 88/257 (34%), Gaps = 46/257 (17%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQ 75 IE+E VV+ G + I + + + EL T C I + Sbjct: 5 IEVEYWVVDNEGALTAPGELADISEFTET--------EFVDCLFELKTPPCETIPELRRT 56 Query: 76 FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF-G 134 F + VL A + + GT + E+ +ER + + G A G Sbjct: 57 FVEQFRTVLDRAAELDKALVPLGTP--INSESIELRADERGEIQRQLLGTNFDYAKHCAG 114 Query: 135 QHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF--ASSRPNIFSA---- 188 H+H + D + L L +AL +SPY QG + +S+R +I+ Sbjct: 115 THIHFEKRNVTDQLNTLIALDP----ALALCNSSPYFQGE---YVASSARAHIYRRQCYA 167 Query: 189 -FPDNGPM----PWVSNWQQ-----FEALFRCLSYTTM----------IDSIKDLHWDIR 228 P++G + V+ W + F+ + + +D + +R Sbjct: 168 DLPNHGQLWNYVDTVAEWHRRLEHCFDEFTERAAANGISRAQIDEHFTVDDA--VWAPVR 225 Query: 229 PSPHFGTVEVRVMDTPL 245 TVE R D L Sbjct: 226 LRDEMPTVEWRSPDATL 242 >UniRef50_A7HH96 Glutamate--cysteine ligase n=5 Tax=Cystobacterineae RepID=A7HH96_ANADF Length = 453 Score = 64.8 bits (157), Expect = 4e-09, Method: Composition-based stats. Identities = 53/359 (14%), Positives = 91/359 (25%), Gaps = 75/359 (20%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 LEL+ D++ A + + A D +E G P+ RY+ Sbjct: 98 QLELSGRPFADVHVVAAELDRHIEKCAALARDLGVEFLAVGYRPWGTPATTPWMPKNRYK 157 Query: 118 RTL-----------ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 + F G + + + + P AL A Sbjct: 158 IMRPFLSARGRLAPDMMAMTASAQASFDFS---GEKDLAEKLRVALAIQ---PAVTALYA 211 Query: 167 ASPYMQGTDTRFASSRPNIFSAF-P-DNG-PMPWVS---NWQQFEALFRCLSYTTMI--- 217 SP +QG + + S R ++ P +G + + MI Sbjct: 212 NSPIVQGREIGWKSYRTAVWEETDPARSGLLPFAFEPGFQAEPYRRYVEWALDVPMIFLR 271 Query: 218 --------------------------------DSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 D + + ++R G VEVR D Sbjct: 272 RAGAYRETGGRTFRRFLAEGLEGERATLSDWEDHLTTVFPEVRVK---GVVEVRAADACS 328 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDR 304 +A ++ E + + + A R L G D Sbjct: 329 PAMAKALLAFWKGVLYDRQARAAAWESVEAFTIAERRAFMRTAGREALAGRAPDG----- 383 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSA--------IEALHRQVVSGLNEAQLMRDFVADG 355 R + E LL+ A + + L + SG + A + G Sbjct: 384 RSIQEIARGLLDVAAGGLCRQRCCGERGEDERVWLAPLVERATSGRSPADEALEVFRAG 442 >UniRef50_C1B0M2 Putative uncharacterized protein n=2 Tax=Rhodococcus RepID=C1B0M2_RHOOB Length = 502 Score = 64.8 bits (157), Expect = 5e-09, Method: Composition-based stats. Identities = 56/437 (12%), Positives = 124/437 (28%), Gaps = 103/437 (23%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 LG+E+E +V+ + + +++++ + + ++ + +E+ Sbjct: 45 PRPMLGMEIEFNLVH-SDMTPAMSNLAVLESIDDDAV---FQTELGQFNVEMNVRPGPLN 100 Query: 70 NQAAGQFSAMQKVVLQAATD----HHLEICGGGTHP---FQKWQRQEVCDNERYQRTLEN 122 + + + L A H ++ G P + R+ + N RY++ + Sbjct: 101 GEGTFELERTLRASLHVADARIHGHDAQLVMVGMLPTLELEHLGREWITANPRYEQLNDQ 160 Query: 123 F-----------------------------GYLIQQATVFGQHVHVGCASGDDAIYLLHG 153 ++ +A +H+ A + A + + Sbjct: 161 IFAARGEDIELDLEGVPLEGRAAEKLKVDANSVLPEAACTSLQLHLRVAPDEFAAH-WNA 219 Query: 154 LSRFVPHFIALSAASPYMQGT---------------DTR-----FASSRPNIF--SAFPD 191 +AL+A +P+M G DTR RP ++ + Sbjct: 220 AQCLAGAQVALAANAPFMAGKALWHESRIPIFAQATDTRPLELKNQGVRPRVWFGERWIT 279 Query: 192 NGPMPWVSNWQQFEALFRCLS------------YTTMIDSIKDL--------HW------ 225 + +++ F L + + +L W Sbjct: 280 S----VFDLFEENSRYFPALLPEVSDVDPSAELDAGRVPDLNELQMHNGTIYRWNRPVYD 335 Query: 226 --DIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 D +P +E RV+ T+ + A L+ + + N Sbjct: 336 SDDGKPHLR---IENRVLPAGPTVLDTMANAAFYYGALRGLVESDRPIWSRMSFNAAEEN 392 Query: 284 RFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASS-----AIEALHRQV 338 +YG++ + P G RLL G S+ + + + Sbjct: 393 LHAGAKYGMDAELYWPGVGFAGADELVLRRLLPIADEGLAAFGLSAKARDRYLSVIEGRC 452 Query: 339 VSGLNEAQLMRDFVADG 355 V+ A R V Sbjct: 453 VTRQTGASWQRAQVVRH 469 >UniRef50_C7ML88 Gamma-glutamylcysteine synthetase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7ML88_CRYCD Length = 429 Score = 64.1 bits (155), Expect = 7e-09, Method: Composition-based stats. Identities = 48/316 (15%), Positives = 100/316 (31%), Gaps = 73/316 (23%) Query: 10 EPFTLGIELEMQVV-NPPGYDL--------------------------SQDSSMLIDAVK 42 P LG+E+E VV +P + + ++ A++ Sbjct: 40 APGALGVEVEHFVVTDPDKRPVFYEPRDGKLGVRDVLEYLAQWYPVVDRNSAGEVL-ALR 98 Query: 43 NKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF 102 + + ++ + LE++ ++Q + ++V+ +H ++ G G HP Sbjct: 99 SDEASITIEP---AAQLEISIAPLARVDQVKSAYEHFRRVLDPFLHEHAFQLLGLGYHPT 155 Query: 103 QKWQRQEVCDNERYQRTLENFGYLIQ---QAT--VFGQHVHVGCASGDDAIYLLHGLSRF 157 + E+ +RY+ E+F ++ + V V S DA+ Sbjct: 156 TQALDMELIPKQRYRFMDEHFHHIGTHGERMMRASASTQVSVDFTSEVDAVEKFRVALAL 215 Query: 158 VPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN--GPMP-------WVSNWQQF---- 204 P + +P +G +R N++ + G +P ++ + Sbjct: 216 GPILAYICDNAPVFEGKPNTIPLARLNLWRDVDNARCGIIPGAFDDGWDFGSYADYLLGA 275 Query: 205 -------------------EALFRCLSYTTMIDS-IKDLHWDIRPSPHFGTVEVRVMDTP 244 +A L + I+ I D+R VE+R D+ Sbjct: 276 SPIFVTQPEVRAVGETLARDAYGDRLMDQSDIEHLISMFWPDVRLKQF---VEIRPADSM 332 Query: 245 LTLSHAVNMAGLIQAT 260 A LI+ Sbjct: 333 P-ADCIYGYAALIKGI 347 >UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanococcus vannielii SB RepID=A6US46_METVS Length = 367 Score = 63.3 bits (153), Expect = 1e-08, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 95/282 (33%), Gaps = 44/282 (15%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELATD-VC 66 +G E E + + + S ++I + KI + ++ + ++E Sbjct: 2 IGTEHEYSIND-FNFKAMPISDVIIKEITGKIQNEFFLDTIGISKELQKHVIEFKPKMPS 60 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF------QKWQRQEVCDNERYQRTL 120 I K + + G G HP W E + Y R Sbjct: 61 GSIKDLEKMLYDGMKDFHSRTNNC-YNLMGLGMHPLLDLNGTAFWDHDEREVFDTYDRVF 119 Query: 121 E--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 G+L + V+V +S DD + + + +P+ +AL+A+SP ++G T++ Sbjct: 120 NLKQHGWL----NIQSIQVNVSYSSEDDMVLKHNKIRTMIPYLVALTASSPMVEGKLTKY 175 Query: 179 ASSRPNIF----SAFP-DNG--PMPWVSNWQQFEALFRCL-----------SYTTMIDSI 220 A +R + P G + +E L + ++S Sbjct: 176 ADNRLIYYKENQKEIPEITGKIIPEPLLKSSDYEDLLEKMYMELKEKEAQVLCQEWVNSR 235 Query: 221 KDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAH 262 + +R VE++ MD ++ + ++ LI Sbjct: 236 GLI---VRRERKC--VEIKAMDEQESIHADMAISALINCLIR 272 >UniRef50_C0EWU2 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EWU2_9FIRM Length = 819 Score = 63.3 bits (153), Expect = 1e-08, Method: Composition-based stats. Identities = 58/372 (15%), Positives = 110/372 (29%), Gaps = 85/372 (22%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE+E + D ML + D +E+ E+ T V I A Sbjct: 412 FGIEME-------SLRVVGDG-MLSQTAHPFPGDAHIVRDFSENQTEINTGVNESIEAAI 463 Query: 74 GQFSAMQKVVLQA--ATDHHLEICGGGTHP-FQKWQRQEVCD-------NERYQR-TLEN 122 + + + + A + P + + Y+ + Sbjct: 464 EELKGHTRRIQEKLKALPEPELLWPFSNPPYIGGEKDVPIAQFDGKDAHKTAYREYLSDK 523 Query: 123 FGYLIQQATVFGQHVHVGCAS----GDDAIY---------------LLHGLSRFVPHFIA 163 +G + T G HV+ + D A+ L ++ + +A Sbjct: 524 YGRY--KMTFSGSHVNFSFSEDLLRADFALQSEPDFMKYKNKLYLELAQKIAVYGWILVA 581 Query: 164 LSAASPYMQG-----------TDTRFASSRPNI---FSAFPDNGPMPWVSNWQQFEALFR 209 ++AASP + T +S R + ++ FP P S+ + Sbjct: 582 VTAASPIVDSSFMEKGVYGKSVFTGLSSVRCSELGYWNEFP---PTFDYSDIDSYVNSIE 638 Query: 210 CLSYTTMIDSIKDLHWDIRPSP---------------HFGTVEVRVMDTPL------TLS 248 ++ + +L++ IR P H +E+R+ D Sbjct: 639 KYVKNGLLKAPSELYYPIRLKPAGENNLISLRKNGIDH---IELRMFDLNPLTGAGIDAR 695 Query: 249 HAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 Q WL T + +KD + N A Y L+ V R + Sbjct: 696 D----VKFAQLLMVWLATMPSWYVSKKDQVNAVQNFKNAAHYDLKTVKIARTEKRARSIV 751 Query: 309 EDTLRLLEKIAP 320 + L+++ + Sbjct: 752 HEALKVIGWMKE 763 >UniRef50_UPI0001C36E32 Glutathione synthase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C36E32 Length = 381 Score = 62.9 bits (152), Expect = 2e-08, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 84/281 (29%), Gaps = 56/281 (19%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E V+ G L D + D E+ +EL T VC I +A Sbjct: 12 FGLERETLRVDSHG--------KLADTPHPFGNDEHITRDFCENQIELVTPVCSSIKEAV 63 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEVCD-------NERYQRTLENFGY 125 + + + D++ I P F + D Y+ LE Y Sbjct: 64 ASLAELDAKARKILDDNNESIWLYSNPPHFDSEADIPIADFTGDHSSKRAYREVLEQ-KY 122 Query: 126 LIQQATVFGQHVHVGCAS----------------GDDA-IYLLHGLSRFVPHFIALSAAS 168 + G H + D + L L + L+AAS Sbjct: 123 GKKLMLFSGIHFNFSFDEEFIRELNTDGQDFHSFRDSLYLRLYKQLMAHSWLLVLLTAAS 182 Query: 169 PYMQGT-----DTR-----FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMID 218 PY + + ++S R + + P+ + + F + T + Sbjct: 183 PYYDASLDKDGKSGIIMSEYSSLRNSSRGYWNKFLPILDHRSLRSFTGSIKKHIVTGSLY 242 Query: 219 SIKDLHWDIRPSPH------------FGTVEVRVMDTPLTL 247 S +L+ IR P +E+R+ D + Sbjct: 243 SASELYLPIRLKPKGVNSLENLASNGVDHIELRMFDLDPSA 283 >UniRef50_Q6Z3A3 Glutamate--cysteine ligase B, chloroplastic n=81 Tax=cellular organisms RepID=GSH1B_ORYSJ Length = 496 Score = 62.9 bits (152), Expect = 2e-08, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 49/160 (30%), Gaps = 8/160 (5%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 EL+ ++Q + ++ V + + G G P + RY+ Sbjct: 145 QFELSGAPLETLHQTCAEVNSHLYQVKAVGEEMGIGFLGIGFQPKWALSDIPIMPKGRYE 204 Query: 118 RTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 G L V++ +S D I P A+ A SP+ + Sbjct: 205 IMRNYMPKVGSLGLDMMFRTCTVQVNLDFSSEQDMIRKFRTGLALQPIATAIFANSPFKE 264 Query: 173 GTDTRFASSRPNIFSAFP--DNG-PMPWVSNWQQFEALFR 209 G + S R +I++ +G + FE Sbjct: 265 GKPNGYLSLRSHIWTDTDNNRSGMLPFVFDDSFGFERYVD 304 >UniRef50_A1WVT1 Glutamate--cysteine ligase, GCS2 n=2 Tax=Ectothiorhodospiraceae RepID=A1WVT1_HALHL Length = 476 Score = 62.5 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 47/119 (39%), Gaps = 12/119 (10%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC---- 66 P ++G+ELE +V+ G + S ++ V++ V++++ LE+ TDV Sbjct: 42 PPSIGLELEAWLVDADGRP-APISDRVLSRVED----PRVENELARFNLEINTDVHPLAG 96 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR---QEVCDNERYQRTLEN 122 + + + +AA D + G P + + + + RY E Sbjct: 97 TPLQGLQTELAERWARTQRAAADAGCRLALVGILPSVREADVCVENMTPSPRYAALNEQ 155 Score = 58.3 bits (140), Expect = 4e-07, Method: Composition-based stats. Identities = 33/127 (25%), Positives = 47/127 (37%), Gaps = 5/127 (3%) Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +E RVM TL+ + A L RP +E + + + N + A RYGLE Sbjct: 326 LEHRVMAAGPTLADVLANAAFFYGAVAELAESRPGLVEELPFHIAEQNFYAAARYGLEAE 385 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSA-----IEALHRQVVSGLNEAQLMRD 350 + R T RLL K + G + A + L +V SG A Sbjct: 386 VEWLDGWFGRLGDLVTERLLPKARRGLVRAGVAEAEATAHLGVLEERVASGRTGAAWQLA 445 Query: 351 FVADGGS 357 +V G Sbjct: 446 WVERHGE 452 >UniRef50_C6MEH3 Putative uncharacterized protein n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MEH3_9PROT Length = 474 Score = 62.5 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 59/412 (14%), Positives = 111/412 (26%), Gaps = 80/412 (19%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA- 73 G ELE +++ Y S + + + N + V +++ EL Sbjct: 46 GYELEFWLID-HNYFPSPINQAFLTRLNNPL----VVPELSCFNAELNGVPLPLRGDVLT 100 Query: 74 ---GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLEN--FGY 125 + + +AA + G P + + + D RY+ E Sbjct: 101 AISQELNQNWLQCQEAAHGMDSVLMMIGILPTVRQKDLCLSNMSDLRRYRALNEQVVMQR 160 Query: 126 LIQ---------------------QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 + + +A +H+ A D A+ + +A Sbjct: 161 VGRPLHIRIKGRENLDIYHPDVMMEAAATSFQIHLQSAQRD-AVRYFNASIIAAGPILAA 219 Query: 165 SAASPYMQGTD-------------------TRFASSRPNIFSAFPDNGPMPWVS-NWQQF 204 + SP++ TD + R + + + N Sbjct: 220 AGNSPFLFDTDLWDETRVPLFEQSVEIVDEANLENHRVSFGQGYARESLFECFAHNIATH 279 Query: 205 EALFRCLSYT------TMIDSIKDLHWDIRP---SPHFGT----VEVRVMDTPLTLSHAV 251 L L T + + IRP H GT +E RV+ + T+ + Sbjct: 280 PVLLPMLMDTPTQQFEHLRLHNGTIWRWIRPLIGFDHDGTPHLRIEQRVLPSGPTIVDMM 339 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT---DPHTGDRRPLT 308 A L +L + + N + A R GL + D T + Sbjct: 340 ANAALYFGLVRFLADLGDAPESRLSFEQARNNFYAAAREGLRARMVWWNDNVTDAKTLF- 398 Query: 309 EDTLRLLEKIAPSAHKI-----GASSAIEALHRQVVSGLNEAQLMRDFVADG 355 +L + + + +V SG A R + Sbjct: 399 --IEEILPMARQGLKDLKIDKADIDHYLGVIEMRVQSGQTGAVWQRAYREKH 448 >UniRef50_A9GBM5 Glutamate--cysteine ligase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GBM5_SORC5 Length = 458 Score = 61.8 bits (149), Expect = 4e-08, Method: Composition-based stats. Identities = 56/417 (13%), Positives = 113/417 (27%), Gaps = 101/417 (24%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSM--LIDAVKNKITAGEVKHD----------ITES--- 57 +G E E V+ +++ ++ + + + + Sbjct: 37 RIGAEAEKFGVDARTGAAIPYEGERSVLNILQALVERHGWTPEHETPGGPLIALARAGAS 96 Query: 58 -------MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 LEL+ +I+Q + S + + + L G G HPF + Sbjct: 97 VTLEPGGQLELSGAPLENIHQICMEMSGHLAELRDISAELKLAWLGIGFHPFARQDDLSW 156 Query: 111 CDNERYQRTLENFG-------YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 RY ++++ + AS + A+ L R P A Sbjct: 157 VPKARYAIMRRYLPTRGAHGLDMMRRTAT--VQANFDYASEEAAMRALRVSLRLSPLVTA 214 Query: 164 LSAASPYMQGTDTRFASSRPNIF-------SAFPDNGPMPWVSNWQQFEALFRCLSYT-- 214 + A SP+ +G S R ++ N + ++F Sbjct: 215 IFANSPFYEGALFGGRSYRAKVWLDVDAARQGLIRN----VLERGRRFSDYVAWAVDAPM 270 Query: 215 -------TMIDSIKDLH-----------------WDIRPSPHFG------TVEVRVMDTP 244 +I++ W++ + F T+EVR D+ Sbjct: 271 FLFKRDGEVIENTGQTFRDFLEHGFEGHRATRGDWEMHLNTLFPEVRLKRTLEVRGADSL 330 Query: 245 LTLSHAVNMAGL-------IQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 + + L +A F+ E + + K +A R Sbjct: 331 P-ANLVCALPALWAGILYDARALDEADALSESFRFDELEAVRPKIAE-RALR-------- 380 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHK--------IGASSAIEALHRQVVSGLNEAQ 346 T +PL RL+ + + ++ L + G + A Sbjct: 381 --ATFRGKPLAALAERLVAIASGGLARRARLNKNGKDERVHLDRLSALIAKGQSPAD 435 >UniRef50_A4T5Z6 Glutamate--cysteine ligase, GCS2 n=28 Tax=Actinomycetales RepID=A4T5Z6_MYCGI Length = 448 Score = 61.4 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 57/352 (16%), Positives = 101/352 (28%), Gaps = 67/352 (19%) Query: 7 HVSEPFTLGIELE---MQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P +G+E+E + +P + + +I + V + +EL+ Sbjct: 58 KDVPPGPVGLEIEAHCYDLSDPFRRPGWDELTAVIADLPRLPGGSLVTVE-PGGAVELSG 116 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 A + V+ L + G P + R V RY F Sbjct: 117 PPATGTADAVSAMVTDRAVLRDVFAGAGLGLVLLGADPLRPAGR--VNPGSRYAAMERFF 174 Query: 124 GY-----LIQQATVFGQHVHVGCASGDDA-----IYLLHGLSRFVPHFIALSAASPYMQG 173 V V +G A + L H L P IA++A SP + G Sbjct: 175 AESGTPEAGAAMMTSTASVQVNLEAGHRAGWADRVRLAHALG---PTMIAIAANSPVLAG 231 Query: 174 TDTRFASSRPNIFSAFPDNGPMPWVS--------NWQQFEAL------------------ 207 T + S+R ++S P + +W ++ Sbjct: 232 KFTGWHSTRQLVWSQLDSARCGPILGVDGDDPASDWARYALRAPVMLVHTPEAVPVTQWV 291 Query: 208 -FRCLSYTTMIDSIK------------DLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMA 254 F + ++ + L +RP G +EVR +D+ AV A Sbjct: 292 PFADWADGRVLLDDRRPTLADLDYHLTTLFPPVRPR---GFLEVRYLDSVP---DAVWPA 345 Query: 255 GLIQATAHWLLTERPFKHQEKDYLLYKFNRF-QACRYGLEGVITDPHTGDRR 305 + T LL + + + +A + GL+ Sbjct: 346 VVF--TLSTLLDDPVAADVAAEATEPVATSWDRAAQLGLDDRRLHTAAVRCV 395 >UniRef50_C4DKI0 Putative uncharacterized protein n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DKI0_9ACTO Length = 456 Score = 61.4 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 67/443 (15%), Positives = 128/443 (28%), Gaps = 94/443 (21%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--AGEVKHDITESMLELATDVCRDIN--- 70 +ELE+ +V+ + S + ++ + V+ ++ LEL Sbjct: 1 MELELSLVD-ESGEPSMTNHEVLSHLAENAVANGDSVQDELGRFNLELNLGPRPVAGFGF 59 Query: 71 QAAGQ-FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---CDNERYQRTLEN---- 122 + Q + V A H + GT P + + + RY+ + Sbjct: 60 ETYEQRLRLWLQDVNDCARKEHSSVVMVGTLPTVRREHARLDILSRRPRYRLLNDQILSV 119 Query: 123 ------------------FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 + ++ H+ + + +A Sbjct: 120 RGEDISLDISGAETLRAHTDSIAPESVNTSVQFHLQLT-PEQFPRYWNAAQAMAGVQLAT 178 Query: 165 SAASPYMQGTDTRFASSRPNIFSA--------FPDNGPMP-------WVSNWQQ-FEA-- 206 +A SPY+ GT +A +R +F G P W+++ FE Sbjct: 179 AANSPYLFGTQ-LWAETRIILFEQATDIRNGELRVQGVRPRAWFGERWITSATDLFEENL 237 Query: 207 --LFRCL-----------SYTTMIDSIKDLH-------------WDIRPSPHFGTVEVRV 240 L + I + +L +D+ P VE RV Sbjct: 238 KYFVPLLPQCVSEDPIEKVNSGEIPQLGELRLHNGTIYRWNRPVYDVGPEGPHLRVENRV 297 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + T L + + + + N A R+G++ T P Sbjct: 298 VPAGPTPIDICANMAFYLGLVTALAEADMPIWTKLPFAVAEQNFHAAARHGIDAHQTWPG 357 Query: 301 TGDRRPLTEDTLR-LLEKIAPSAHKIG-ASSAIEALHRQVV----SGLNEAQL------- 347 G+ P L LL K A + S+ E L + +G+N A Sbjct: 358 LGEL-PARVLVLDHLLPKAAEGLAALDVDSAVAERLLAIIAGRCRNGVNGAAWQVNCVQR 416 Query: 348 --MRDFVADGGSLIGLVKKHCEI 368 R ++ +L ++ ++ E Sbjct: 417 LQQRQGLSRTPALHEMLSRYAEH 439 >UniRef50_B9LUZ8 Putative uncharacterized protein n=8 Tax=Halobacteriaceae RepID=B9LUZ8_HALLT Length = 519 Score = 61.4 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 61/439 (13%), Positives = 113/439 (25%), Gaps = 103/439 (23%) Query: 14 LGIELEM-QVVNPPGYDLSQDSSMLIDAVKNKITAGE-VKHDITESMLELATDVCRDIN- 70 +G E E V + + S+ + V ++ + ++ E++T + Sbjct: 49 VGFEYEFYAVADGRWSEESRAGEYALMRVPRRLLELMGFEKELGLHNAEMSTSPQPLSDH 108 Query: 71 QAAGQFSAMQKVVLQA---ATDHHLEICGGGT---HPFQKWQRQEVCDNE---------- 114 Q + ++ + A A + + P + R + D+ Sbjct: 109 GLRAQLAEVRARLEAAENTAGVEGMRLVSDALWTIPPTGETARGYLTDSVDVDGVTVAVN 168 Query: 115 -----RYQRTLENFGYLIQ------------------QATVFGQHVHVGCASGDDAIYLL 151 RY G + ++ + H A D Sbjct: 169 MSDAVRYHAMANTGGDEHRGTVVKAPGVSLAADTVMPESLITSIQPHYQVAQADTLPQHF 228 Query: 152 HGLSRFVPHFIALSAASPY---------MQGTDT---RFASSRPNIFS------------ 187 R +AL SP+ G +R ++F Sbjct: 229 RYALRIAGPLLALGVNSPFFPPDLYDEGWDGERVLAEGATENRIHVFESVLNARTDEGKV 288 Query: 188 AFPDNG-----------------PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRP- 229 FP PMP +F+ F W +RP Sbjct: 289 RFPREFHDIETAVDRIVADETLIPMPEPEGTDRFDDEFATFRT----KHGSYWRW-VRPV 343 Query: 230 ------SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 S +E R + T+ ++ L ++ D+ + N Sbjct: 344 FEGASRSSANARIEFRPIPGQPTVRDSIAFQAAFAGL-MQALPQQEHPVIGLDWETARDN 402 Query: 284 RFQACRYGLEGVI-TDPHTGDRRPLTEDT-LRLLEKIAPSAHKIGASSA-----IEALHR 336 + A GL+ I G+R T+ LL+ G + L Sbjct: 403 FYAAVAGGLDAEIEWVGLDGERTTDTDALYADLLDHAEAGLRTAGCPDEEAAAWLAPLRW 462 Query: 337 QVVSGLNEAQLMRDFVADG 355 +V + A RD V + Sbjct: 463 RVANRTTPASWKRDRVRER 481 >UniRef50_D0RQE4 Glutamate--cysteine ligase, (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQE4_9RICK Length = 442 Score = 61.0 bits (147), Expect = 7e-08, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 53/160 (33%), Gaps = 8/160 (5%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 +EL+ C I+ + + K + QA L I G G P K +RY Sbjct: 85 QIELSGAPCGTIHDTCREVNLYLKELKQACAKLGLGIIGIGFVPNVKINEIHKLKKKRYS 144 Query: 118 RTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 + G L V+ +S DD S VP ++L + SP ++ Sbjct: 145 IMRDYMPKVGTLGLDMMHRTAATQVNFDFSSEDDFRKKTKVASCLVPVAVSLFSNSPVLE 204 Query: 173 GTDTRFASSRPNIFSAFP--DNG-PMPWVSNWQQFEALFR 209 G F R NI+ +G + +E Sbjct: 205 GKLNGFIGYRTNIWQHTDDNRSGLIPFFFDKENSYEQYCD 244 >UniRef50_Q2S261 CBS domain pair protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S261_SALRD Length = 605 Score = 60.6 bits (146), Expect = 9e-08, Method: Composition-based stats. Identities = 61/431 (14%), Positives = 114/431 (26%), Gaps = 92/431 (21%) Query: 23 VNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKV 82 V+ D + +++ ++ + ++T +E D R Q A Sbjct: 2 VD-ERGDPAPVIEEVLERNSDE----RIVTELTRYNVEFNMDPLRFGGDCFQQMEASTSE 56 Query: 83 VLQ----AATDHHLEICGGGTHPFQKWQRQEV---CDNERYQRTLE---NFGYLIQQATV 132 +++ EI G P + RY + Q + Sbjct: 57 LVETVRGLTQQVDSEIALTGILPTAHLSDFAMDYMTPRPRYYALNDAISRLRGGAGQYQI 116 Query: 133 FGQ-------------------HVHVGCASGDDAIYLLHGLSRFVPHFIALSAASP---- 169 G H S ++ + +A + SP Sbjct: 117 RGIDELFVKHDSIMLEGCNTSFQTHFQV-SPEEFPRYYNIAQVVAAPCLAAATNSPLLFG 175 Query: 170 -----------YMQGTDTRF-------ASSRPNIFSAFPDNGPMPWV-SNWQQF------ 204 + Q DTR S R + + + D M + +F Sbjct: 176 KRLWRETRIALFQQAVDTRSTNLYLREMSPRVHFGTDWVDESVMEIFKEDISRFRVLLTT 235 Query: 205 ---EALFRCLSYTTMID------SIKDLH-W--------DIRPSPHFGTVEVRVMDTPLT 246 E L + + ++ W D +P +E RV+ + T Sbjct: 236 ELGEDSLETLEAGGVPNLKALQLHNGTVYRWNRACYGITDGKPHLR---IENRVLPSGPT 292 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + + A L E + D+ ++N A R GL G RP Sbjct: 293 VIDEIANAVFWYGLVAGLAHEYRDVSEHIDFYEARYNFNAAARSGLASQF-TWLDGSNRP 351 Query: 307 LTEDTLRLLEKIAP------SAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 E L L +A + + ++V + AQ D +A + Sbjct: 352 AHELILDTLIPLAEEGLRTSDIASSDIDRYLGVIQKRVETQQTGAQWQLDSLARMEEVGS 411 Query: 361 LVKKHCEIWAG 371 ++ + G Sbjct: 412 RAERLGALTRG 422 >UniRef50_A4FGC2 Glutamate-cysteine ligase n=3 Tax=Actinomycetales RepID=A4FGC2_SACEN Length = 412 Score = 60.6 bits (146), Expect = 9e-08, Method: Composition-based stats. Identities = 61/343 (17%), Positives = 96/343 (27%), Gaps = 68/343 (19%) Query: 6 FHVSEPFTLGIELEMQV---------VNPPGY--DLSQDSSMLI---DAVKNKITAGEVK 51 F P GIELE V ++P L + + + + Sbjct: 33 FKTGPPRLHGIELEWTVHHDDDPSRPLDPEVLISALGPHAPPSLVPGSPHRPLPNGSSLT 92 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E+++ + +A + + L + GT P++ +R V Sbjct: 93 VE-PGGQVEVSSLPSPSVRSLFDVVAADADHLRRLLRPSGLSLGEQGTDPWRHPRR--VL 149 Query: 112 DNERYQRT---LENFGYLIQQAT--VFGQHVHVGCASGDD---AIYLLHGLSRFVPHFIA 163 RY + G + G V + LH L P +A Sbjct: 150 QVPRYAAMESAFDRIGIDGRLMMCSTAGVQVCLDAGEPHRIAPRWAALHALG---PVMLA 206 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAF--PDNGP----MPWVSNWQQ--FEALFRCLSYTT 215 A SP + G DT + S+R P P + W + + CL Sbjct: 207 TFANSPKLFGHDTGWLSTRTRAVLRTDPPRTRPGPVSPDPATGWARRMLDTALVCLRRDG 266 Query: 216 M------------------IDSIKDLHWDIRPSPHFGTV------EVRVMDTPLTLSHAV 251 + D S F V EVR +D + Sbjct: 267 VDWTVPGGISFAEWISGALAGPPTMDDLDYHMSTVFPPVRARGYLEVRYLDAQPGDDWML 326 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKF-NRF-QACRYGL 292 A LI L E E L + R+ A R+GL Sbjct: 327 PAAALI------ALFEAESTVDEVLRLTARTPGRWMHAARHGL 363 >UniRef50_D1PL70 Putative glutamate--cysteine ligase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PL70_9FIRM Length = 410 Score = 59.8 bits (144), Expect = 2e-07, Method: Composition-based stats. Identities = 39/299 (13%), Positives = 80/299 (26%), Gaps = 57/299 (19%) Query: 12 FTLGIELEMQVVNPPGYDLS-QDSSMLIDAVKNKITAG-EVKHDIT-------------E 56 TLG+E+E V + G ++ + ++ ++ + + Sbjct: 25 LTLGLEVEHFVTHAGGEPVTFGEIQSVMRQMQQPYDTPIMIDGEYMGYTTEQYSVSLEPA 84 Query: 57 SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY 116 +E++ + + ++ + L HP ++ + + +RY Sbjct: 85 CQVEISIMPQSSVLKIMDIYNQFYLQLSMTLAARGLRAWTVSYHPTRRAEELPLIPKQRY 144 Query: 117 QRTLENFGYLIQ---QAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM 171 + F Q + V S D + + P F LS + Sbjct: 145 EAMDRYFKNTGSCGIQMMRATASTQLSVDYYSERDFVQKMRAACLLTPFFALLSDNAVQY 204 Query: 172 QGTDTRFASSRPNIFSAF--PDNGPMPWVSNWQ-QFEALFRCLS-----------YTTMI 217 Q S R I+ G P + + FE + T + Sbjct: 205 QAHRNNAYSVRTRIWQDVDSDRCGVPPHLMDPDFGFERYAETILTRPLIVALRGNRTKAV 264 Query: 218 DS-------------------IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 + +D R + VE+R D + A L+ Sbjct: 265 GRKSAQEIYGSHLLKKEVEHVLSMFFFDARLKTY---VEIRGAD-CMPPKFIAAYAQLV 319 >UniRef50_B1KDI6 CBS domain containing protein n=1 Tax=Shewanella woodyi ATCC 51908 RepID=B1KDI6_SHEWM Length = 636 Score = 59.5 bits (143), Expect = 2e-07, Method: Composition-based stats. Identities = 61/430 (14%), Positives = 122/430 (28%), Gaps = 104/430 (24%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G E E +V+ D + + L++++ + +++ LE D A Sbjct: 44 RIGAEQEFFLVD-EHMDPAPLAMTLLESMNDPC----FTNELALFNLEANLDPHEFTKDA 98 Query: 73 ----AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLENFGY 125 Q + K +L+ + E+ G P +++ + RY + G Sbjct: 99 ISKTEQQLQELYKKLLKHIAAENGEVITTGILPTIRYRDLTLDNLTPQPRYFALNDTLGQ 158 Query: 126 --------LIQQA----------TVFGQ----HVHVGCASGDDAIYLLHGLSRFVPHFIA 163 I+ + VH + D A + + +A Sbjct: 159 QRGEDCKLYIRGQDELSFSHDNVLIEACNTSFQVHFQVSQQDFA-HYYNISQAITAPLLA 217 Query: 164 LSAASP---------------YMQGTDTR-----FASSRPNIF--SAFPDNGPMPWV-SN 200 ++A SP + Q DTR S P ++ S + + + + Sbjct: 218 IAANSPLLLGKRLWHETRIALFQQAIDTRQSNLNLRESEPRVWFGSQWVKSSVLELFQED 277 Query: 201 WQQFEALFRCLSYTTMID---------------SIKDLH-WDIRP-------SPHFGTVE 237 +F+ L T + ++ W+ RP PH +E Sbjct: 278 ISKFKVLISNDIETDSMAQLKQGQVPKLDALCMHNGTVYRWN-RPCYGVQNNVPHLR-IE 335 Query: 238 VRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI- 296 RV+ + T+ A+ + + + K F A + + V Sbjct: 336 NRVLPSGPTIVDAIANMAFFLGL--------MNGYGSRLDDVTKIMDFSAAKKNFDNVSM 387 Query: 297 ------TDPHTGDRRPLTEDTLR-LLEKIAPSA-----HKIGASSAIEALHRQVVSGLNE 344 G+ P E R L+ + I + ++V N Sbjct: 388 RSLNTDIVWFNGEVIPCAELIERELIPVAREGLALANIDQTDIDKYIGIIEQRVAKRTNG 447 Query: 345 AQLMRDFVAD 354 + M Sbjct: 448 SIWMLRNFEK 457 >UniRef50_B4WP90 Putative uncharacterized protein n=3 Tax=Cyanobacteria RepID=B4WP90_9SYNE Length = 382 Score = 59.5 bits (143), Expect = 2e-07, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 98/313 (31%), Gaps = 38/313 (12%) Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP----FQKWQRQEVCDNE 114 +E+ T V I++ + + + A HP F + + Sbjct: 87 IEIRTTVHDSIDETLAELIESFERLRIEAKKSGFSPALISFHPHRSQFIPIPPLNNYEQQ 146 Query: 115 RYQRTLENFGYLIQQATVFGQHVHVGCA--SGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 R ++ G +++ S I + L+ + P I S +SP+ Q Sbjct: 147 R-RQKSPEMQTAHIPMLTQGPDLNLSAEGLSPTQLIDIGRKLTYYSPFIIPFSYSSPFYQ 205 Query: 173 GTD-TRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP 231 G + + S+R F G P A+ T +IDS L R Sbjct: 206 GREWSGL-SART-----FYRTGARP--------AAMVFVEQATDLIDSTPSLTQIARIPA 251 Query: 232 HFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYG 291 G +E + D+ + G + A L+ ++ + + + + R+G Sbjct: 252 EVGRIEFKAFDSCGDFE----LYGSLLALLKGLVLDQSLQGRATIPEAKQHQH--SARFG 305 Query: 292 LEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDF 351 +L ++ + + L ++ + A M + Sbjct: 306 FADETI----------YNQAQAILAAVSQVELEAEEHDRLTKLQERLTQRRSPANGMIEA 355 Query: 352 VADGGSLIGLVKK 364 G S++ ++++ Sbjct: 356 YRQGESIVNILQR 368 >UniRef50_D2RSK6 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RSK6_9EURY Length = 517 Score = 59.5 bits (143), Expect = 2e-07, Method: Composition-based stats. Identities = 63/464 (13%), Positives = 108/464 (23%), Gaps = 121/464 (26%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC----RDI 69 +G+E E V L + L++ + + ++ E+ T + Sbjct: 48 VGLEYEFYAVKNDDCALRRVPRRLLELIG-------FEKELGLHNAEMTTSPQPMNAHGL 100 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC------------------ 111 + A + L + + Sbjct: 101 AAQESEVKARLQTALNVTQSERMRLVSDALWTLPPEGEDATTYLTDSVERTTTDDDGTER 160 Query: 112 ---------DNERYQRTLENFGYLIQQATVFGQHV------------------HVGCASG 144 D+ RY + HV H A Sbjct: 161 SFRIATNMSDSARYHAMANTDQAESAGMCIQAPHVSLQADTVMPESLITSIQPHYQVAHA 220 Query: 145 DDAIYLLHGLSRFVPHFIALSAASPY-----MQGTDT-------RFASSRPNIFSAF--- 189 D + R +AL SP+ T + R ++F Sbjct: 221 PDLPDYFNYALRIAGPLLALGVNSPFFPADLYDDEATPEEILRDGWMEHRISVFETVLND 280 Query: 190 PDNG--------------------------PMPWVSNWQQFEALFRCLSYTTMIDSIKDL 223 P G + ++F+ F S Sbjct: 281 PTTGEGKVRFPRDLGTVEEAIDRIADDDTIVPMPIEAGERFDDQFPHFSR----KHGTYW 336 Query: 224 HWDIRPSPHFGT-------VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKD 276 W IRP T +E R + T+ +V L T E D Sbjct: 337 RW-IRPVFGGPTRSAANARIEFRPIPAQPTVRDSVAFLAAFAGLMESL-TRLEHPVLELD 394 Query: 277 YLLYKFNRFQACRYGLEGVI--TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEA- 333 + + N + A GLE + + LL G S A Sbjct: 395 WQRARENFYAAMVDGLEAELNWITNDGKETSDTLALYEDLLAHAEDGLTNRGLSEEEAAK 454 Query: 334 ----LHRQVVSGLNEA----QLMRDFVADGGSLIGLVKKHCEIW 369 L R+V + A + +R +ADG L ++ + + Sbjct: 455 YLYPLRRRVRQTVTPASWKRERVRSALADGADLDAAIEAMQQAY 498 >UniRef50_D0L3Q4 Glutamate--cysteine ligase, GCS2 n=78 Tax=Actinomycetales RepID=D0L3Q4_GORB4 Length = 502 Score = 58.7 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 60/427 (14%), Positives = 117/427 (27%), Gaps = 97/427 (22%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV---- 65 LG+E+E+ +++ + + ++ ++DA+ + + + ++ + +E+ Sbjct: 45 PEPLLGMEVELNLID-DAMNPAMANAAVLDAIAD----PDYQTELGQFNIEINVSPRPFF 99 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDNERYQRTLEN 122 D Q A + G P + + Q + N RY + Sbjct: 100 ADDTISLEQALRTSLNRAEQRAARTANHLVMVGMLPTLRTEHFAHQWISANPRYDLLNQQ 159 Query: 123 F-------------------GYLIQQATVF-----------GQHVHVGCASGDDAIYLLH 152 G ++ +H+ A D A + + Sbjct: 160 IFAARGEDLELDITGIPLGEGATSERLHTSTDSILAEAACTSLQLHLRVAPEDFAAH-WN 218 Query: 153 GLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA--------FPDNGPMPW------- 197 +AL+ SP++ G S R +F + G P Sbjct: 219 AAQAIAGIQVALAGNSPFLAGHALWHES-RIPVFEQATDTRPLELKNQGVRPRVWFGERW 277 Query: 198 ----VSNWQQFEALFRCLS------------YTTMID-------SIKDLH-WDIRP---- 229 +++ F L I ++ W+ RP Sbjct: 278 INTIFDLFEENTRYFPALLPVSSDVDPLEQLDNGEIPTLDELKLHNGTVYRWN-RPVYDV 336 Query: 230 ---SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ 286 H VE RV+ T+ + A L+ + + N Sbjct: 337 VDGHAHLR-VENRVLPAGPTVVDILANAAFYYGVVRGLVEADRPLWSQMSFNAAAENLQS 395 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGA-----SSAIEALHRQVVSG 341 R GLE I P+ G RP RLL G S + + + ++ Sbjct: 396 GARSGLESQIYWPNVGWVRPDELTLRRLLPIADDGLRSFGVSGKARSRYLSVIEGRCINR 455 Query: 342 LNEAQLM 348 + Sbjct: 456 QTGSVWQ 462 >UniRef50_D1VG95 Glutamate/cysteine ligase family protein n=1 Tax=Frankia sp. EuI1c RepID=D1VG95_9ACTO Length = 442 Score = 57.9 bits (139), Expect = 6e-07, Method: Composition-based stats. Identities = 36/190 (18%), Positives = 62/190 (32%), Gaps = 26/190 (13%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAV----KNKITAGEVKHDITESMLELATDVCRDI 69 +GIE E VV+ D A+ + + + EL+ Sbjct: 44 VGIETEWFVVDRHSPDSPVAPERTRAALAGCGPDLPGGSRITFE-PGGQFELSGPPLALP 102 Query: 70 NQAAG---QFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG-- 124 +A++ + L + G G P + +R + RY E F Sbjct: 103 AALRAMSADLTAVRLRLAD----DGLLLAGLGADPLRAPRRLLT--HSRYAAMEEFFQTG 156 Query: 125 -YLIQQATVFG---QHVHVGCASG---DDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 + + V++ +D L H L P +A+ A+SP + G T Sbjct: 157 GFPAGPLMMCSTAALQVNLEAGPRSGWEDRWRLAHTLG---PVLVAMFASSPVLAGRPTG 213 Query: 178 FASSRPNIFS 187 S+R I+S Sbjct: 214 QVSTRQGIWS 223 >UniRef50_C7RFC6 Glutamate--cysteine ligase n=3 Tax=Anaerococcus RepID=C7RFC6_ANAPD Length = 432 Score = 57.9 bits (139), Expect = 6e-07, Method: Composition-based stats. Identities = 62/412 (15%), Positives = 114/412 (27%), Gaps = 92/412 (22%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSM--LIDAVKNKITAGEVKHDI------------- 54 + F +G E E VV+ + + +++ KH+ Sbjct: 22 KDFAIGFESEHFVVDKDSLETVSYYGEDGIAQSMEEIAKDSYEKHEEDGKILGLSKDRFD 81 Query: 55 ----TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 S E+A + I+ + ++ + G HP K + ++ Sbjct: 82 ISVEPASQFEIALKSRKKIDDLYEDYKKAMAEIVPVFEKKGQVLANVGYHPKSKIEDIKI 141 Query: 111 CDNERYQRTLENF----GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 +RY E F G + +S +D + F+A Sbjct: 142 IPKKRYDYMYEYFRINGGAYAHNMMKGTASLQCAIDYSSEED-------FRKKY--FVA- 191 Query: 165 SAASPY----------MQGTDTRFASSRPNIFSAF--PDNGP-MPWVSNWQQFEALFRCL 211 SA SP+ +G + R I+ G + +E R + Sbjct: 192 SALSPFLYSIFDNAYIFEGEVYGKRNLRQMIWDNCDRQRTGVYPFAFDDDFSYEKYAREI 251 Query: 212 SYTTMI--DSIKDLHWDIR-------------------PSPHFGTV------EVRVMDTP 244 T +I + H+ R S F V E+R+ D Sbjct: 252 LNTDIIFVHEDGEDHYKGRLKFSEVMDKDSSDEMIFHALSIVFPDVRAKKYIEIRMPDEV 311 Query: 245 LTLSHAVNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 + +A LI+ L + DY R ++ RYGL D Sbjct: 312 PYPYNFAALA-LIKGLFYDEENLDRLYEIFTDMDYRSLTNFRSRSERYGLHATYKD---- 366 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASS-AIEALHRQVVSGLNEAQLMRDFVA 353 E L+ + + + + ++ L + + RD Sbjct: 367 -----KEIYKWALDFVEMAKRSLEDEAHYLKPLREILEEEKSP----RDIYE 409 >UniRef50_A6TWY9 Glutamate--cysteine ligase n=2 Tax=Alkaliphilus RepID=A6TWY9_ALKMQ Length = 446 Score = 57.5 bits (138), Expect = 7e-07, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 90/311 (28%), Gaps = 75/311 (24%) Query: 11 PFTLGIELEMQVVNPPGYDLS-----QDSSMLIDAVKNKITAGEVKHDITES-------- 57 LG E E VV Q ++ A+ K E + D + Sbjct: 22 ELKLGAEFEHIVVWKDTMKSVSYYEEQGIEDILKALLEKGYEAEYEGDYLIALKKEAYYI 81 Query: 58 ------MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 LE++ C I + + ++ ++ + G HP + Sbjct: 82 TLEPGGQLEISVVPCSTIESVQSIYFQFLEEIIPIMENNGQLLLAIGYHPKSSIKEIPFN 141 Query: 112 DNERYQRTLENFGYLIQQATVFGQH---------VHVGCASGDDAI---YLLHGLSRFVP 159 RYQ + + QH V + + +D I + + LS P Sbjct: 142 PKVRYQYMSNYL----KDKGTYSQHMMKGTAAIQVSIDYRNEEDFIKKFKVANFLS---P 194 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAF--PDNGPMPWVSN----WQQFEALF----- 208 ++ SP +G D R I+ +G +P V N ++ + Sbjct: 195 LLHLITDNSPRFEGEDYLGHGLRSVIWQNTDKDRSGVIPGVMNERFGYEAYAKYILGIPP 254 Query: 209 ------RCLSYTT--MIDSI---------------KDLHWDIRPSPHFGTVEVRVMDTPL 245 L T I + + D+R + +E+RV D+ Sbjct: 255 ILMKKEGQLIETGNQSIGEVLKENDLTGEEIEHLLTMVFPDVRVK-RY--IEIRVGDSLP 311 Query: 246 TLSHAVNMAGL 256 + +A L Sbjct: 312 YPYNFAYIALL 322 >UniRef50_Q0RAS7 Glutamate--cysteine ligase GSHA (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) n=3 Tax=Frankia RepID=Q0RAS7_FRAAA Length = 523 Score = 55.6 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 44/209 (21%), Positives = 73/209 (34%), Gaps = 31/209 (14%) Query: 2 PLPDFHVSEPFTLGIELEMQVVN-----------PPGYDLSQDSSMLIDAVKNKITAG-E 49 P P + ++GIE E VV+ L + S ++ A + G Sbjct: 88 PEPSVGIGT--SVGIETEWFVVDTRVVHQPVPPERTRRALGRISGLITGAAGPVLPGGSR 145 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + LEL+ + A +A +V A + L I G G P + RQ Sbjct: 146 LTFE-PGGQLELSGPP-AGLAAAVQSTAADLHLVRAALAEDGLAIVGMGVDPLRAGVRQ- 202 Query: 110 VCDNERYQRTLENFGYLIQQAT------VFGQHVHVGCAS----GDDAIYLLHGLSRFVP 159 RY E+F + V++ + + L H + P Sbjct: 203 -TTASRYAAMEEHFRTGGGTSGEVMMRSTASVQVNLDLGTTPAQAAERFRLAHAVG---P 258 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSA 188 A+ AASP + G T + S+R ++S Sbjct: 259 VLTAMFAASPALAGRRTGWRSTRQAVWSG 287 >UniRef50_C1DH93 Glutamate-cysteine ligase-like protein n=1 Tax=Azotobacter vinelandii DJ RepID=C1DH93_AZOVD Length = 392 Score = 55.6 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 42/315 (13%), Positives = 89/315 (28%), Gaps = 59/315 (18%) Query: 15 GIELEMQVVN---PPGYDL----SQDSSMLIDAVKNKITAGEVKHDITESM--------- 58 GIE E +V+ P L + D L + + +K G+ ++ E Sbjct: 23 GIEFEYLLVDTRGPQAGRLRDIHALDVPRLAELLADKPGLGD--PELAEGDLGIRNGYWY 80 Query: 59 --------------------LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGG 98 +E+ T + A +++ + L + G Sbjct: 81 LEGDERFDLEGRLVGFVAKGVEIRTPPRPSVAVAIDCLLDIERQLAARLERDGLGLAIAG 140 Query: 99 THPFQKW--QRQEVCDNERYQRTLEN-FGYLIQQATVFGQHVHVGCASGDDA--IYLLHG 153 P + + + ER R + + + +G +++ + Sbjct: 141 FDPLRTRYGYQPPLNAFERRLRAGDREYEGMELSMLTYGPDLNLSLPDWSTRRNLDAARK 200 Query: 154 LSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSY 213 L+ + P+ + S +SPY G + P V + E Sbjct: 201 LNYYAPYIVPFSFSSPYCAGQP-----WHGWSRRTWLRCEQRPAVKLFLGLEEYAEQAER 255 Query: 214 TTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAH-WLLTERPFKH 272 + ++ R + G +E + D ++ +A L + Sbjct: 256 SPLLRP-------ARLAREAGRIEFKAFDAMPSVE---LLAACCHLLTGICLANNLRGRS 305 Query: 273 QEKDYLLYKFNRFQA 287 + D LY+ A Sbjct: 306 ETPDVALYRRAALHA 320 >UniRef50_A1ZDC2 CBS domain pair protein n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZDC2_9SPHI Length = 662 Score = 54.4 bits (130), Expect = 6e-06, Method: Composition-based stats. Identities = 62/437 (14%), Positives = 127/437 (29%), Gaps = 92/437 (21%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M D+ P +G E E+ +V+ + S ++ A+ + +++ +E Sbjct: 32 MLENDWFEQAPIRIGAEQEVCLVD-EHGKPAPKSMEILAALNH----PSFTTELSRFNIE 86 Query: 61 LATDVCRDINQ----AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---CDN 113 + + ++ + A D + G P + ++ Sbjct: 87 ANLSPVEFTGDCFSRVQKELDDLMDLIHKTAHDLEARVILTGILPTIRKFDLDIENLTPI 146 Query: 114 ERYQRTL---ENF-GYLIQQATVFGQ-------------------HVHVGCASGDDAIYL 150 +RY L E G + + G VH+ D + Sbjct: 147 DRYYALLQAIERLRGKAAYELKIEGLDELNLKHDSALIEACNTSFQVHLQVTPQDF-VSK 205 Query: 151 LHGLSRFVPHFIALSAASP---------------YMQGTDT-------RFASSRPNIFSA 188 + + +S+ SP + Q DT R+ S R + Sbjct: 206 YNIAQAISAPVLGVSSNSPMLFGKRLWNETRIALFQQSVDTRITNEHLRYTSPRVTFGNG 265 Query: 189 FPDNGPMPWV-SNWQQFEALFRCLSYTTMIDSIKD----------------LHWDIRP-- 229 + N + + +F+ L ++DS+K+ W+ RP Sbjct: 266 WVKNSILDLYKEDIVRFKVLLTTDVKEDVLDSVKNNKTPQLQALSIHNSTVYRWN-RPCY 324 Query: 230 ------SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 PH +E R++ + T V + + P + ++ K N Sbjct: 325 GISPNGKPHLR-IENRILPSGPTTLDEVANSAFWVGLMNGFEEAYPDVTKVLEFDDVKAN 383 Query: 284 RFQACRYGLEGVITDPHTGDRRPLTEDT-LRLLEKIAPSAHKI-----GASSAIEALHRQ 337 + R GL G G E LL K + +E + + Sbjct: 384 FIKTARTGL-GSKHHWVHGKTVNDIELIQKELLPIARIGLEKAKVDEKDINKYLEIIEDR 442 Query: 338 VVSGLNEAQLMRDFVAD 354 +G+N ++ + + Sbjct: 443 TETGMNGSRWILKSYSK 459 >UniRef50_Q6ANW2 Glutathione synthetase n=1 Tax=Desulfotalea psychrophila RepID=GSHAB_DESPS Length = 779 Score = 54.1 bits (129), Expect = 8e-06, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 108/369 (29%), Gaps = 76/369 (20%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G E E V+ G L+ L K + + D +ES +E+ T I ++ Sbjct: 24 FGFEKENIRVDSRGKLALTPHPREL----GEKTSHPYITTDFSESQIEIITPPLPSIAES 79 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ---RTLENFG----- 124 G + +V D + + P + +++ + R E + Sbjct: 80 LGFLETLHDLVSIELKDEY--LWPQSAPPILPEREEDI-PIAHFGGEFREQEEYRLQLAK 136 Query: 125 -YLIQQATVFGQHVHVGCASG----------------DDAIYL-LHGLSRFVPH---FIA 163 Y ++ G H ++ + + + + F+ H I Sbjct: 137 IYGRKRQMFSGIHFNISLPERFLELLHEEGKQEQPFAEFREDIYMKTVRNFLRHRWFLIC 196 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAF-PDNGPMPWV-----------------------S 199 L ASP + S R + P S Sbjct: 197 LLGASPVI------HKSYRKHCIDMLSPFAKDAYHFPYATSIRNNICGYRNTQDFHLNYS 250 Query: 200 NWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP-----HFGTVEVRVMDTPLTLSHAV--N 252 + + L ++ I++ + IR +E+R++D V Sbjct: 251 TLTDYRESLQELVEKKVLRDIRENYAPIRIKTTTDPKRINHLEIRLLDLNPFFKTGVNPL 310 Query: 253 MAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE-GVITDPHTGDRRPLTED 310 A +I + LL K+ N+ QA GL G I G+ + L + Sbjct: 311 HAEIIHIFLIYCLLCPEETSFTSKEQETANRNQEQAATEGLNPGAIICDADGNEQRLDKQ 370 Query: 311 TLRLLEKIA 319 L++I Sbjct: 371 LAHCLQEIQ 379 >UniRef50_A1A2R1 Possible glutamate--cysteine ligase n=18 Tax=Bifidobacterium RepID=A1A2R1_BIFAA Length = 432 Score = 53.7 bits (128), Expect = 1e-05, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 51/177 (28%), Gaps = 15/177 (8%) Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 LE + + + A + A ++ V + + G P + V +RY+ Sbjct: 113 QLETSIGILHKPEELATLYGAFRREVDPILEELGFRLVNYGYQPKSSYADIPVNPKDRYK 172 Query: 118 RTLENFGYLIQQATVF------GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM 171 G + Q V + S DAI L + P +PY Sbjct: 173 AMTAYLGRVG-QFGPCMMRCSASTQVSIDYVSEQDAIAKLRLGTVIGPILAWFFRNTPYF 231 Query: 172 QGTDTRFASSRPNIFSAF---PDNGPMPWVS---NWQQFEALFRCLSYTTMIDSIKD 222 +G + + R ++ N W+ + LS M + Sbjct: 232 EGGENPYPPLRQRMWDYLDFQRTNVIPGLFDPRFGWEDYA--VDVLSTPMMFADLTH 286 >UniRef50_B0S3P4 Glutamate-cysteine ligase n=2 Tax=Finegoldia magna RepID=B0S3P4_FINM2 Length = 434 Score = 52.9 bits (126), Expect = 2e-05, Method: Composition-based stats. Identities = 61/418 (14%), Positives = 127/418 (30%), Gaps = 79/418 (18%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQ-----DSSMLIDAVKNKITAGEVKHDITE-------- 56 E FT+G+E+E +V+ + + N A + D Sbjct: 22 EDFTIGMEMEHFIVDKDTLKTVSYFGDNGVGATLRELHNHGCAAYKEGDYILGLENDDLA 81 Query: 57 ------SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 S E+A +I+ + + +++ + + G HP K ++ Sbjct: 82 VSTEPGSQFEVALSSKWNIDDLKDIYIKNMRKLVEIFDKKNQAMVTLGYHPVTKIDEIKI 141 Query: 111 CDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIY---LLHGLSRFVPHFI 162 +RY + F G + + +S D + + + LS P F Sbjct: 142 LPKKRYDFMYKYFNERGDMAHNMMKGTCSLQCSIDYSSEKDFVRKYKIANCLS---PVFY 198 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAFPD--NGP--------------------MPWVSN 200 L + +G ++ + R I+ +G P + + Sbjct: 199 TLFDNAYIFEGEPSKSRNMREIIWENTDTDRSGMYKFSFDDDLSYKKYAEHILNTPLIFS 258 Query: 201 WQQ-----------FEALFRCLSYTTMIDSIKDLHW-DIRPSPHFGTVEVRVMDT---PL 245 + F+ +F + T +I + + D+R + + +E+R+MD PL Sbjct: 259 IDENHEPYYVGKTTFKEVFEDVKDTGLIFHALSIVFPDVR-AKRY--IEIRMMDEIKYPL 315 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 S + GL + L + + Y + A GL+ + + Sbjct: 316 NFSAVALIKGLFYDEVN--LDKLSELFKNMTYENCMKAKLDAREKGLDATFMNVN----- 368 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 + E L++ + L + G+N + G +V Sbjct: 369 -MLEFCKMLVDMAKNGL-PANEIGYLIPLEEMLEKGMNPRDQFEKIYKEKGLREAVVA 424 >UniRef50_UPI000180C776 PREDICTED: similar to Glutamate-cysteine ligase, catalytic subunit n=1 Tax=Ciona intestinalis RepID=UPI000180C776 Length = 638 Score = 52.5 bits (125), Expect = 3e-05, Method: Composition-based stats. Identities = 39/195 (20%), Positives = 59/195 (30%), Gaps = 76/195 (38%) Query: 145 DDAIYLLHGLSRFVPHFIALSAASPYMQG----TDTRF----ASS--R----PNIFSAF- 189 D+A L L+ + P IALSAASP+ +G TDTR+ AS R + Sbjct: 272 DEAKLLYDQLAPWCPIMIALSAASPFYRGYITDTDTRWGVISASCDDRNATERQVLKRLS 331 Query: 190 ----PDNGPMPWVSNWQQFEALFR-----------CLSYTTM------------------ 216 P +GPM + Q++ L + Sbjct: 332 TDLKPRHGPMELYLSP-QYQKYNDLNSKMNKEAKNTLLKGGVEDGIANHIAHLWVRDPLN 390 Query: 217 -------IDSIKD----------LHWDIRPSPHFGT--------VEVRVMDTPLTLSHAV 251 ID + + + +R P T +E RV+D LT Sbjct: 391 LYSGRINIDDETEADHFEYIQSTVWYSLRFKP--PTPDNSIGWRIEFRVLDGQLTDFENA 448 Query: 252 NMAGLIQATAHWLLT 266 + +L Sbjct: 449 AYIVFVVLLTRVILA 463 >UniRef50_C3JX20 Glutamate--cysteine ligase family protein n=5 Tax=Nocardiaceae RepID=C3JX20_RHOER Length = 407 Score = 52.1 bits (124), Expect = 3e-05, Method: Composition-based stats. Identities = 55/374 (14%), Positives = 96/374 (25%), Gaps = 80/374 (21%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITE--------- 56 F P +G ELE PG + ++ + + + D Sbjct: 29 FKQGPPRLVGAELEWLTSQVPGGERPSAAT--LAKALGRHAPTSIDPDSPAVPLPRGSLV 86 Query: 57 -----SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 +EL++ + ++ + + +EI + Sbjct: 87 TVEPGGQIELSSAPRTSARELCDCLDEDRRTLETLLASYSIEISSAAA--DVARPPSRIL 144 Query: 112 DNERYQRTLENF---GYLIQQATVFGQHVHVGCASGDDAIYLLHG---LSRFVPHFIALS 165 RY F G V V +G + L P IA Sbjct: 145 RLPRYCAMESRFAGIGPYGTLMMCNTAAVQVSVDAGGSPESIAQRWRLLGDMGPALIAAF 204 Query: 166 AASPYMQGTDTR-FASSRPNIF---SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIK 221 A SP +QG +AS R + ++ V ++ + + + + Sbjct: 205 ACSPRLQGVPRGDWASQRMRTWLELDSWRTVAVPE-VQDYAGWALDVPLM----CVRNEG 259 Query: 222 DLHWDIR----------------------------------PSPHFGTVEVRVMDTPLTL 247 D R P G +EVR +D Sbjct: 260 DDWTAPRGATFGDWIDGALDAEIGRRPVWADLDYHLSTLFPPVRAVGHLEVRYIDAQPGD 319 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRP 306 V +A + LL+ + D R++ A YGL+ + R Sbjct: 320 LWRVPVAAI-----DALLSGPAVMREASDAAASTAGRWRDAAEYGLD-------DVELRS 367 Query: 307 LTEDTLRLLEKIAP 320 + L AP Sbjct: 368 AATSLMSLAASYAP 381 >UniRef50_C4RDQ5 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromonospora RepID=C4RDQ5_9ACTO Length = 537 Score = 51.4 bits (122), Expect = 5e-05, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 56/201 (27%), Gaps = 24/201 (11%) Query: 6 FHVSEPFTLGIELEMQV---------VNPPGY--DLSQDSSMLIDAVKNKIT---AGEVK 51 F P G+ELE V V+ L S ID V Sbjct: 16 FKTGPPTRTGVELEWTVHDAADPARPVDRERLRAALGPHSPTTIDDSSPAAPLRHGSTVT 75 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEV 110 + +E++T + +A V L + G P W+ + Sbjct: 76 VE-PGGQIEISTAPRSSVAALIEATNADIAQVTDLLRRAGLLLGRTGIDP---WRLPRPT 131 Query: 111 CDNERYQRT---LENFGYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALS 165 D RY+ + G + G V + + P +A Sbjct: 132 VDTPRYRAMRCVFDRGGPAGRTMMYSTAGLQVCLDAGEPAHVAARWAAVHAVGPPLLAAF 191 Query: 166 AASPYMQGTDTRFASSRPNIF 186 A + G T +AS+R + Sbjct: 192 ATADRHAGRRTGWASARMAAW 212 >UniRef50_D2MHE8 Putative uncharacterized protein n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHE8_9BACT Length = 268 Score = 51.0 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 20/143 (13%), Positives = 45/143 (31%), Gaps = 13/143 (9%) Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +E R + + T V + L ++ + N ++ ++GL+ V Sbjct: 108 IEFRSLPSGPTPLDMVANTAFLVGMVEGLSSQMEELLPSFPFEYAHHNFYRGAQFGLDAV 167 Query: 296 ITDPH----TGDRRPLTEDTLRLLEKIAPSAHKIG-ASSAI----EALHRQVVSGLNEAQ 346 + P + P+ + L LL ++G + I E + ++ A+ Sbjct: 168 LLWPSIQYPSPREVPVCDLALDLLPVAERGLAQLGVEAGEISRMSEVIRTRIERRCTGAR 227 Query: 347 LMRDFV----ADGGSLIGLVKKH 365 R + +V Sbjct: 228 WQRRMLDHLEQQSSRRQAVVALL 250 >UniRef50_B2A6L2 Glutamate--cysteine ligase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6L2_NATTJ Length = 462 Score = 51.0 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 62/379 (16%), Positives = 116/379 (30%), Gaps = 81/379 (21%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V+ G LS +K+ +K D +ES +EL T VC+ I +A Sbjct: 52 FGLEKENLRVDEQGNLALSPHPKE----FGDKLRNPYIKTDFSESQIELITPVCKSIEEA 107 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLE 121 +Q V + + P + Q RY +R + Sbjct: 108 YEFLGELQDFV--SVRLTGEYLWPQSNLPKLPEEEQ--IPIARYGKEGYKERKYRERLAK 163 Query: 122 NFGYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHF 161 +G + + G H + D + + L ++ Sbjct: 164 KYGK--KLQLLSGVHFNFSLKEEFLNKLYARLEHNKSYQEFKNDIYLKITKYLLKYRWLL 221 Query: 162 IALSAASPYMQGTDT------RFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYT- 214 I L+ ASP ++ D F S R + + +++ E L + Sbjct: 222 IYLTGASPTLKTADNLGCYCKDFRSLRNSSCG---YSNNEELYISYETIEDYVASLQASI 278 Query: 215 --TMIDSIKDLHWDIRPSPH-FGT-----------VEVRVMDTPL------TLSHAVNMA 254 I +I + + +R GT +E+R+ D + Sbjct: 279 DQGKIQNINEFYSPVRIKGRGKGTLEELLKQGIQYLELRLFDLNPFDKNGISKEDLY--- 335 Query: 255 GLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC---RYGLEGVITDPHTGDRRPLTEDT 311 + +LL + F + + N QA R E + G L E+ Sbjct: 336 -FTRLLITYLLVKADFTFGTMEQKMANTNHEQATLAER--PENIGVFDELGQWENLQEEA 392 Query: 312 LRLLEKIAPSAHKIGASSA 330 +++ ++ +G + Sbjct: 393 TKIINELEELIEVLGGETE 411 >UniRef50_Q7W897 Putative uncharacterized protein n=4 Tax=Bordetella RepID=Q7W897_BORPA Length = 494 Score = 50.6 bits (120), Expect = 9e-05, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 61/218 (27%), Gaps = 41/218 (18%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITE---------- 56 S TLG+ELEM V + + GE + Sbjct: 4 AQSVGHTLGLELEMVVACRATGASHPVARHFESLRNLRRQRGESVQECRLGARLCGVGGP 63 Query: 57 ----------SMLELA-TDVCRDINQAAGQFSAMQKVVLQ---AATDHHLEICGGGTHPF 102 ++LE A V A+++ + A + HP Sbjct: 64 HGLSGLDNGYNLLETAFAPVNGGAGGLRRLAEAVRRELRDTQLALAAEGAMLINAAEHPA 123 Query: 103 Q----KWQRQEVCDNERYQRTLENFGYLIQ-------QATVFGQHVHVGCASGDDAIYLL 151 W R+ Y+ + G+L + Q + V V A L Sbjct: 124 ASLDADWYRRVRVPRPIYEELVGQRGWLHRIGIDAKAQNSPC-TSVPVAI-----AARCL 177 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + + P IA+ A SP G T +R ++ Sbjct: 178 NVVLALAPAQIAMFANSPLEAGRVTGLKENRLTLWPRM 215 >UniRef50_C7QH01 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenulispora acidiphila DSM 44928 RepID=C7QH01_CATAD Length = 366 Score = 50.6 bits (120), Expect = 9e-05, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 56/190 (29%), Gaps = 24/190 (12%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDA---VKNKITAGEVKHDITESMLELA 62 F P +G+ELE + + D S ++ A + +G + + EL+ Sbjct: 21 FKTGPPSRVGVELEWFPRDARHPEHLPDRSRVLRAFADAADLPLSGTLTME-PGGQWELS 79 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGG---THPFQKWQRQEVCDNERYQRT 119 + + + ++ ++A + LE+ G G HP + D+ RY Sbjct: 80 SAPADSVRELIAVTDRDLTLLRRSAAEAGLELVGMGREHGHP-----PSRLVDHPRYVAM 134 Query: 120 ---LENFGYLIQQAT--VFGQHV-------HVGCASGDDAIYLLHGLSRFVPHFIALSAA 167 + + V H G L H LS + S Sbjct: 135 EHFFDRDNGSGRVMMCSTASIQVNLDAGTEHDGPEDFRRRWRLAHRLSPVLTAVFCRSDR 194 Query: 168 SPYMQGTDTR 177 D Sbjct: 195 PAVWAAIDPG 204 >UniRef50_C9NAH4 Putative uncharacterized protein n=1 Tax=Streptomyces flavogriseus ATCC 33331 RepID=C9NAH4_9ACTO Length = 596 Score = 49.4 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 46/119 (38%), Gaps = 9/119 (7%) Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLE 293 V VR+ D +T++ + A L+QA + W L + ++ L + NR +A +GL Sbjct: 227 VTVRLFDAQVTVAGTLAHALLVQALSMWSRDLERTGRRVRQVPQFLLEQNRARAVAHGLA 286 Query: 294 GVI-TDPHTGDRRP-----LTEDTLRLLEKIAPSAHKIG-ASSAIEALHRQVVSGLNEA 345 + D P LL ++ P ++ + + L V + A Sbjct: 287 AELRVDQTRRTEEPPRTQSAGRAVRTLLSELLPYLRQLDATTDELAPLFLGVEMAGSAA 345 >UniRef50_Q8YYX1 All0721 protein n=4 Tax=Nostocaceae RepID=Q8YYX1_ANASP Length = 372 Score = 49.1 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 62/200 (31%), Gaps = 36/200 (18%) Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP--FQKWQRQEVCDNERY 116 +E+ T + I A + S ++ A + HP + + E Sbjct: 82 IEIRTTIHSSIQNAITELSDSFNLLCGVAAEFGFSPVLTSFHPYKTSFAPNPPLNEYE-- 139 Query: 117 QRTLENFGYLIQQA------TVFGQHVHVGCAS--GDDAIYLLHGLSRFVPHFIALSAAS 168 L+ +G +++ A + I + L+ + P+ + S +S Sbjct: 140 ---LKQLQADPDDQTANIYMVTYGPDLNISVADLPHERVIDIGKKLTYYSPYIVPFSYSS 196 Query: 169 PYMQGTDT---RFASSRPNIFSAFPDNGP-MPWVSNWQQFEALFRCLSYTTMIDSIKDLH 224 P+ G T S R I G + Q+ E L + S+ + Sbjct: 197 PFYNG--TLWEGL-SVRTFI-----RTGKRPATLIFVQEKEQLIN------SVPSLTKI- 241 Query: 225 WDIRPSPHFGTVEVRVMDTP 244 R G +E + D+ Sbjct: 242 --ARLPAEVGRIEFKAFDSC 259 >UniRef50_D2RSM6 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RSM6_9EURY Length = 513 Score = 48.7 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 57/202 (28%), Gaps = 49/202 (24%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC- 66 S F LG+ELE V+ G + V + + G + ++ +E T+ Sbjct: 41 DSPGFGLGLELEAYAVDEAGR---------LARVPDAVFEGRCERELGRHNVEFNTEPTP 91 Query: 67 ---RDINQAAGQFSAMQKVVLQAATDHHLEIC--GGGTHP--------FQKWQRQE---- 109 I A Q + A LEI T P +E Sbjct: 92 FDGSGIAVQAAQLERRVRKAQSDAEADGLEIVLDAMWTRPPPEGAREYLAATTEREGVAL 151 Query: 110 ---VCDNERYQRT-------------------LENFGYLIQQATVFGQHVHVGCASGDDA 147 + ++ RY E F L+ ++ HV + Sbjct: 152 AENMTESARYYAIDNDVLARTGGEIALSVPGVEETFPSLLFESLTSSVQPHVQIPDVEAF 211 Query: 148 IYLLHGLSRFVPHFIALSAASP 169 + + +AL+ SP Sbjct: 212 PRYYNTALGTLGPVLALATNSP 233 >UniRef50_Q1WVP8 Glutamate--cysteine ligase n=12 Tax=Lactobacillus RepID=Q1WVP8_LACS1 Length = 452 Score = 47.1 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 54/147 (36%), Gaps = 13/147 (8%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 + FT+G+E+EMQ V+ LSQ+ A+ ++ T + +D E+M E+ T Sbjct: 13 EAVAKTSDFTMGLEIEMQRVD-DTGHLSQEPYP--SAIGDEKTNPWITNDFLETMSEVVT 69 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP-------FQKWQRQEVCDNERY 116 A A+ V+ A + P + + + Sbjct: 70 PAASHALDAMHYLYAINNVLRSALAP-GELLWPLSMPPKLPKDKSTIQTAKMGPVKEAYF 128 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCAS 143 + ++ G+ + T G H+++ Sbjct: 129 KEFIKRHGF--SKGTPCGAHINLSIDD 153 >UniRef50_Q03Q55 Glutamate--cysteine ligase n=1 Tax=Lactobacillus brevis ATCC 367 RepID=Q03Q55_LACBA Length = 505 Score = 46.7 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 58/162 (35%), Gaps = 23/162 (14%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E+E ++ G LSQ + ++ ++ D TES LE+ TD +I Sbjct: 23 VGLEIEEHRIDQHGR-LSQRPHP--RQLGSRTIHPYLQTDFTESQLEVITDPNPNIGGTL 79 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN--ER-----YQR-TLENFGY 125 Q +Q V ++ I P + N ER Y+ + +G Sbjct: 80 DQLDTLQTVAYRSLAGDD-RIWPLSMPPKLDETDLQFVRNHFERPAIKPYREHLIHKYGL 138 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFV----PHFIA 163 + + G HV+ +++ L P +A Sbjct: 139 --KHGCMTGVHVNYSLPD-----PVINRLYSHYTQEFPTLVA 173 >UniRef50_D1N7M9 Glutathione synthase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7M9_9BACT Length = 740 Score = 46.4 bits (109), Expect = 0.002, Method: Composition-based stats. Identities = 59/423 (13%), Positives = 112/423 (26%), Gaps = 109/423 (25%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G+E E +L++ + + + K D ES +EL T C Sbjct: 31 RIGVERESLRC-TASGELAETAHP--ETLGRKDDNPFFTADWAESQIELKTPPCESPLAC 87 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC-------DNERYQRTLENFGY 125 + + L+ H + T + C +N R ++ E + Sbjct: 88 HRFLETLTDIALRELAARHELLWPLSTPCLLPEPDRIACARFENAAENLRRRKLREKY-- 145 Query: 126 LIQQATVFGQHVHVGCASG-------------------DDAIYLLHGLSRFVPHFIALSA 166 ++ + G H + G I L+ + F + S Sbjct: 146 PVEMLLLSGIHYNFSFDDGLLRRIAGDGELQAVREGCYLKTIRNLYRMLWFAVGLLGASP 205 Query: 167 -------------ASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSY 213 SP A R + S+ + + Sbjct: 206 ASAGDREIQVSIRNSP---------AGYRTLSSARL-------DYSSVRAYRESVDRCLK 249 Query: 214 TTMIDSIKDLHWDIRP---------SPHFGTVEVRVMDTPL-------TLSHAVNMAGLI 257 +I + +L+ IR +P +E+R+ D + Sbjct: 250 AGLIATEHELYTPIRLRFAGAATDDAPEIDRLELRIPDLNPFEKCGISPVDMEFLRLLFF 309 Query: 258 QATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEK 317 + L E + D YG P + +LLE+ Sbjct: 310 HSL---LTDETELEKFADDADAVAE-------YGFS-----PDQSRK------AGKLLER 348 Query: 318 IAPSAHKIGASSAIEALHRQVVSG-----LNEAQLMRDFVADGGSLIGLVK-----KHCE 367 +A +A I S + + Q L+ A+ +R+ + L + E Sbjct: 349 LAETARNI--SVELPDVLEQAGKRLHHPQLSYARRIRETGERSPEWLRLAESYRDQALAE 406 Query: 368 IWA 370 W Sbjct: 407 AWR 409 >UniRef50_Q8XK30 Glutathione synthetase n=11 Tax=Bacteria RepID=GSHAB_CLOPE Length = 778 Score = 46.4 bits (109), Expect = 0.002, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 49/130 (37%), Gaps = 12/130 (9%) Query: 14 LGIELE-MQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E ++V L+ A ++ +K D +ES LE+ T VC + + Sbjct: 26 FGLEKENVRVTESGNLALTPHPK----AFGDREKNAYIKTDFSESQLEMVTPVCNTLEEV 81 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEVC-----DNERYQRTLENFGYL 126 + KVV + + P + + + ++E Y+ L + Y Sbjct: 82 YSFICNLNKVVSLEIMKNGEFLWPQSNPPILPREEEIPIAKLSNREDELYRENLS-YKYG 140 Query: 127 IQQATVFGQH 136 ++ + G H Sbjct: 141 KKKQVISGIH 150 >UniRef50_Q127I4 Glutamate--cysteine ligase n=18 Tax=cellular organisms RepID=Q127I4_POLSJ Length = 537 Score = 46.4 bits (109), Expect = 0.002, Method: Composition-based stats. Identities = 34/179 (18%), Positives = 58/179 (32%), Gaps = 24/179 (13%) Query: 15 GIELEMQVVNPPGY-DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE E P G L+ + L A +T + D +ES +EL T +D Sbjct: 30 GIEKESLRAQPGGGLALTPHPAALGSA----LTHPSITTDFSESQIELVTGAHQDAEATL 85 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ-----------RTLEN 122 + + + + + D E+ + P E R+ R + Sbjct: 86 KELTQIHQFTYRVMQDLGDEMLWVSSMPCGLPTD-ETIPIARFGSSNVGRAKSVYRMGLS 144 Query: 123 FGYLIQQATVFGQHVHVGCAS--GDDAIYLLHGLSRFVPHFIALSAASP-----YMQGT 174 Y + T+ G H + + L+ R + L ASP ++ G Sbjct: 145 HRYGRRMQTISGIHYNWSLPEVTSEQYFALIRNFRRHAFLLLYLFGASPAVCSSFVAGR 203 >UniRef50_C2C3Y2 Bifunctional glutamate--cysteine ligase/glutathione synthetase n=6 Tax=Firmicutes RepID=C2C3Y2_LISGR Length = 782 Score = 46.0 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 93/277 (33%), Gaps = 65/277 (23%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V+ G L+ K +K D +ES +E+ T VC +N+ Sbjct: 27 FGLEKENLRVDRNGHLALTPHP----AIFGPKEDNCNIKTDFSESQVEMITPVCGSVNEV 82 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC-------DNER--YQR-TLEN 122 + +V + E+ ++P +++ D+E Y+ + Sbjct: 83 YDALHNLNNIVNN---EIGEELLWPSSNPAILPPEKDIPIAVYKTKDSEHRVYREHLAKE 139 Query: 123 FGYLIQQATVFGQHVHVGCAS-----------GDDA----------IYLLHGLS--RFVP 159 +G I + G H + A +D + + R++ Sbjct: 140 YGKKI--QLLSGIHYNFSFAEDFLKQLYEKSAPEDTTYHTFKNQLYMQVASYFMKKRWL- 196 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSA--FPDNGPM------------PWVSNWQQFE 205 + L+ ASP + T +++RP ++ P G P + FE Sbjct: 197 -LVYLTGASPVFENDFTAISNARPLNQNSSYLPT-GMSLRNSAHGYKNSEPLNVKYDTFE 254 Query: 206 ALFRCL---SYTTMIDSIKDLHWDIRPSPHFG--TVE 237 + + IDS+++ + IR T+E Sbjct: 255 NYIQSIANYIEAGTIDSMREYYNPIRLKNAHTDQTLE 291 >UniRef50_B2SNT5 Glutamate--cysteine ligase n=3 Tax=Xanthomonas oryzae pv. oryzae RepID=B2SNT5_XANOP Length = 393 Score = 45.2 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 60/401 (14%), Positives = 107/401 (26%), Gaps = 72/401 (17%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 + +G E E G+ L D + + ++ LEL+ I Sbjct: 10 AQWRIGTEHEQF-----GFRLDDLRPPTFDGERGIEASVTLEP---AGQLELSGAPLHTI 61 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF---GYL 126 + + + V Q A L G G P + + +R++ G L Sbjct: 62 HDTCVEVGSHLNEVKQVADQLGLGFLGMGFQPKWSREAMPLMPQDRHKIMQAYMPNVGAL 121 Query: 127 IQQATVFG------------------------QHVHVGCASGDDAIYLLHGLSRFVPHFI 162 V++ AS D + P Sbjct: 122 GLDMMTRTRTRTRTRTRTCTCTCTCTCTCTCTVQVNLDYASEADMVKKFRVSLALQPIAT 181 Query: 163 ALSAASPYMQGTDTRFASSRPNIF--SAFPDNGPM-PWVSNWQQFEALFRCLSYTTMIDS 219 AL A SP+ +G + S R +I+ + G + + +E L Sbjct: 182 ALFADSPFTEGKPNGYLSYRSHIWIDTDADRTGILDFVFEDGFGYERYLDYLLDV----- 236 Query: 220 IKDLHWDIRPSPHFGT-VE---------VRVMDTPLTLSHAVNMAGLIQATAHWLLTERP 269 +++ S H GT ++ +R D ++ L + Sbjct: 237 --PMYF----SYHDGTYIDASGQSFRDFLRGADARP-WGRLCALSAFWVGL---LYDDPA 286 Query: 270 FKHQEKDYLLYKFNRFQACRYGL-EGVITDPHTGDRR--PLTEDTLRLLEKIAPSA---- 322 + + A R G+ + P D TE L + A Sbjct: 287 LDAAWDLVKDFSRSERHALRDGVPRHALKLPFRNDSVQNLATEAVKIALAGLRRRARLNR 346 Query: 323 HKIGASSAIEALHRQVVSGLNEAQLMRDFVAD--GGSLIGL 361 S +E L + SG A+ G + + Sbjct: 347 DVQDESRFLEPLVEILHSGETAAERKLALYHGVWQGDIDRV 387 >UniRef50_D1VQH9 Glutamate/cysteine ligase family protein n=1 Tax=Frankia sp. EuI1c RepID=D1VQH9_9ACTO Length = 553 Score = 44.4 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 61/218 (27%), Gaps = 48/218 (22%) Query: 11 PFTLGIELEMQVVNPP-----------------------------GYDLSQDSSMLIDAV 41 P ++G+E E VV+ + + AV Sbjct: 80 PRSVGVETEWLVVDRAANDAPVPPERTSAALAPLLATLGSNGSAASGEPAGAVPDATGAV 139 Query: 42 KNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP 101 + + LEL+ ++ A A V A D L + G G P Sbjct: 140 LAGGSRLTFEP---GGQLELSGAPLP-LSAALDAVRADLAQVRAALADAGLALAGLGLDP 195 Query: 102 FQKWQRQEVCDNERYQRTLENFGYLIQQ----ATVFGQHVHVGCA------SGDDAIYLL 151 + R ++RY + V + L Sbjct: 196 LRPPTRWLT--DDRYASMAGYWAASGHDAGRIMMCSSASVQINLDAGADPLDIVRRWRLA 253 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 H L P +A+ AASP G T F S+R ++ + Sbjct: 254 HRLR---PVLVAMFAASPARLGRLTGFGSARTRMWESL 288 >UniRef50_B2GBB9 Glutamate--cysteine ligase n=8 Tax=Lactobacillus RepID=B2GBB9_LACF3 Length = 456 Score = 44.4 bits (104), Expect = 0.007, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 63/172 (36%), Gaps = 32/172 (18%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 F +G+E+EM + +LS +++ ++ N + D TE+M E+ T + Sbjct: 21 FNMGLEVEMHRADNM-GELSPETTPASISLDNPW----ITKDFTETMTEVVTPAANNARD 75 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEVC----DNERY-QRTLENFGY 125 A ++ + A + + + P F Q+ ++ + E Y +R L N G Sbjct: 76 AVHYLYSLNNALRNALAPNEV-LWPLSMPPAFADAQKIQLAKTTPEKEAYLKRVLANMGA 134 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLH--------------GLSRFVPHFIA 163 + + G HV + +++ + + +A Sbjct: 135 VNK-GLPCGVHVSLSIDDR-----VVNMIWEKYQSRFNSKEAVRNHLYILLA 180 >UniRef50_Q97IV1 Glutamate--cysteine ligase n=2 Tax=Clostridium RepID=GSH1_CLOAB Length = 481 Score = 44.4 bits (104), Expect = 0.007, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 44/133 (33%), Gaps = 16/133 (12%) Query: 14 LGIELEMQVVN-PPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E Q VN L+ S+ +K + D +ES +E+ T + + Sbjct: 26 FGVERESQRVNYSGDLALTPHPSV----FGDKFENPRITTDFSESQIEMITPPLKSAEEV 81 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEV-----CDNERYQRTLEN---F 123 + + V A + P K + V ++ R ++ N Sbjct: 82 YKALNDINNEVKNALK--GELLWPLSMPPRLPKEEDIPVAQFPDTEDGRQKQIYRNGLAL 139 Query: 124 GYLIQQATVFGQH 136 Y + + G H Sbjct: 140 RYGKKMQMISGIH 152 >UniRef50_Q18FX4 Putative uncharacterized protein n=2 Tax=Halobacteriaceae RepID=Q18FX4_HALWD Length = 536 Score = 44.0 bits (103), Expect = 0.008, Method: Composition-based stats. Identities = 26/208 (12%), Positives = 58/208 (27%), Gaps = 53/208 (25%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 S+ +G+ELE +V+ L+ + + ++ +E T Sbjct: 49 DSDHVAVGLELEAYIVDSKT-QLAPAPETVFELNG-------CSPELGVHNVEFHTTPDA 100 Query: 68 DINQA----------AGQFSAMQKVVLQAATDHHLEIC-----------------GGGTH 100 ++ A + ++ + D + GT Sbjct: 101 IGAESDNGGSGFRRQASELHHIRDSIRSHIDDVDRTLVYDSLWTIPPETGTDAYLRAGTT 160 Query: 101 PFQKWQRQEVCDNERYQRTLENFGY------------------LIQQATVFGQHVHVGCA 142 + + V RY E ++ ++ H+ Sbjct: 161 EHGIFFAENVRPIPRYIALNEMIRERSGGTVELGLPGLDTAPSMLVESLATSIQPHLQIP 220 Query: 143 SGDDAIYLLHGLSRFVPHFIALSAASPY 170 DA L+ +R + ++L+A SP+ Sbjct: 221 DPRDAAAYLNAATRTMGPLLSLTANSPF 248 >UniRef50_Q65RX0 Glutathione synthetase n=83 Tax=Bacteria RepID=GSHAB_MANSM Length = 757 Score = 42.9 bits (100), Expect = 0.018, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 54/130 (41%), Gaps = 11/130 (8%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T+GIE E Q V+ G ++ + A N+ ++ D ES LEL T + I Sbjct: 20 TVGIEKESQRVHADGSIVTSEHPK---AFGNRSYHPYIQTDFAESQLELITPPNKKIEDT 76 Query: 73 AGQFSAMQKVVLQAATDHHLEI---CGGGTHPFQKWQRQEV--CDNERYQR-TLENFGYL 126 SA+ +V L+ ++ G P Q+ + ++ + Y+ + ++G Sbjct: 77 LRWLSALHEVTLRTIDENEYIFPMSMPAGLPPEQEIRVAQLDNAADVAYREHLVASYGK- 135 Query: 127 IQQATVFGQH 136 + V G H Sbjct: 136 -AKQMVSGIH 144 >UniRef50_C2ZI28 Glutathione synthetase n=10 Tax=Bacilli RepID=C2ZI28_BACCE Length = 767 Score = 42.9 bits (100), Expect = 0.021, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 60/145 (41%), Gaps = 16/145 (11%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAG 74 GIE E + V+ +L++ ++ + ++ D +E +E+ T V + + Sbjct: 32 GIEKESKRVDL-SGNLAKTDHP--KSISLRDDHPYIQRDFSELQMEIITPVTETLEELFD 88 Query: 75 QFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC-------DNERYQR-TLENFGYL 126 +A+ V ++ + + + P + +++ +N +Y++ ++G Sbjct: 89 YLAAIHDVAYRSMGKNEM-LWPLSMPPQLPEKDEDIVIAKLKNAENVQYRQTLSNSYGR- 146 Query: 127 IQQATVFGQHVHVGCASGDDAIYLL 151 ++ + G VH GD+ I L Sbjct: 147 -RKQMLCG--VHFNFEFGDELIQAL 168 >UniRef50_B1MW57 Glutamate--cysteine ligase n=3 Tax=Leuconostoc RepID=B1MW57_LEUCK Length = 486 Score = 42.5 bits (99), Expect = 0.023, Method: Composition-based stats. Identities = 27/132 (20%), Positives = 46/132 (34%), Gaps = 13/132 (9%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE+E V LSQ ++ + T + D +ES E+ T V A Sbjct: 22 FGIEIEEHRVQTDTLSLSQHPHP--ASLGKRKTHPYFQTDFSESQEEVVTAVQSSSAAAL 79 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR----QEVCDNERYQRTLE----NFGY 125 +Q ++ Q+ + I P+ + + + YQ+ + +G Sbjct: 80 QHLHELQFMLTQSLKGNEF-IWPLSMPPYLREADIIFLKTHFERPWYQKYRDVLFLRYGP 138 Query: 126 LIQQATVFGQHV 137 T G HV Sbjct: 139 FQHIMT--GIHV 148 >UniRef50_UPI0000382CE6 COG3572: Gamma-glutamylcysteine synthetase n=1 Tax=Magnetospirillum magnetotacticum MS-1 RepID=UPI0000382CE6 Length = 282 Score = 42.5 bits (99), Expect = 0.027, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 51/171 (29%), Gaps = 25/171 (14%) Query: 26 PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQ 85 G++ D+ +I + A ++ EL+ D++ + A V + Sbjct: 69 TGWEPILDAGNIIGLAGQEGGAISIEP---GGQFELSGAPLPDVHATVAELDAHLAAVKR 125 Query: 86 AATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT-----VFGQHVHVG 140 AA + G P + + RY+ + + V+V Sbjct: 126 AAEPLGIGFLDLGMSPKWTREATPLMPKSRYRIMRNYMPKVGKLGLDMMLRTDTVQVNVD 185 Query: 141 CASGDDAIYLLHGLSRFVPHFIAL--SAAS----PYMQGTDT----RFASS 181 AS D + + + +AL A S P G T + Sbjct: 186 FASEADMVRTM-RVR------LALHPEATSCRQLPLHDGRPTAPCRGYEIW 229 >UniRef50_A7E7E9 Predicted protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7E7E9_SCLS1 Length = 989 Score = 41.3 bits (96), Expect = 0.057, Method: Composition-based stats. Identities = 50/269 (18%), Positives = 80/269 (29%), Gaps = 63/269 (23%) Query: 101 PFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF-VP 159 P + + D + + + YLI G HVH+G +GL F +P Sbjct: 140 PAYYYSEDALTDVADFCKIMRKN-YLITLNASCGLHVHIG-----------YGLRGFELP 187 Query: 160 HFIALSA---------AS--PYM--QGTDTRFASSRPNIFSAF---------PDNGPMPW 197 H L A S P G +T S R F + P + Sbjct: 188 HLRRLGALIEAFEPQLDSIHPAHRIDGQNTHCTSFRRGTFYQWKFRKEEHREPR--VLEA 245 Query: 198 V------SNWQQFEALFRCLSYTTMID--SIKDLH-WD-----IRPSPHF--GTVEVRVM 241 + QF A T + +D RP + T+E R Sbjct: 246 ISTVLTCRTRDQFRAFVASEGPTGTVGFRDGTSSWNFDRMGTETRPKVDWVQDTIEFRGH 305 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF-------QAC--RYGL 292 + L + L+ + F+ + ++ +A RYGL Sbjct: 306 EGSLDPEAVCSWTRLLVGLVKYTREPEMFEFGNLLQRVTGE-KWVKEFLDAKATGERYGL 364 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPS 321 G + P G++ LR+L P+ Sbjct: 365 GGKMYRPIFGEKWCGLVQFLRILGLERPA 393 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya... 400 e-110 UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synecho... 393 e-108 UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=B... 375 e-102 UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeoba... 374 e-102 UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actino... 372 e-101 UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomy... 366 e-100 UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=... 366 1e-99 UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubro... 365 2e-99 UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovi... 365 2e-99 UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bact... 364 3e-99 UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 363 4e-99 UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Le... 363 7e-99 UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia... 362 1e-98 UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinom... 361 2e-98 UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 361 3e-98 UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actin... 357 4e-97 UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium... 356 1e-96 UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterin... 355 1e-96 UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechl... 355 2e-96 UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Plancto... 354 3e-96 UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=No... 353 5e-96 UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinom... 352 1e-95 UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=A... 351 3e-95 UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromob... 351 3e-95 UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Strepto... 350 5e-95 UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cell... 348 2e-94 UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomy... 347 3e-94 UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopir... 347 5e-94 UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangi... 343 7e-93 UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinom... 342 1e-92 UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostoc... 342 2e-92 UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=B... 340 6e-92 UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromono... 339 1e-91 UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus ery... 338 2e-91 UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legione... 338 2e-91 UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 337 5e-91 UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=C... 335 1e-90 UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=... 334 3e-90 UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Sacch... 334 3e-90 UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environ... 333 7e-90 UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salin... 331 2e-89 UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rh... 331 4e-89 UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubro... 330 4e-89 UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia... 329 8e-89 UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales R... 328 2e-88 UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Coryneba... 327 5e-88 UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 327 5e-88 UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromon... 326 6e-88 UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Maripro... 325 1e-87 UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alph... 325 2e-87 UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 324 3e-87 UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobact... 324 4e-87 UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dass... 321 3e-86 UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp.... 318 2e-85 UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Myco... 318 2e-85 UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xantho... 318 3e-85 UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micr... 317 5e-85 UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 316 1e-84 UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineoco... 314 3e-84 UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromono... 312 2e-83 UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces Re... 310 4e-83 UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alpha... 310 5e-83 UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 306 8e-82 UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseud... 304 2e-81 UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=P... 304 3e-81 UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 303 8e-81 UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthr... 301 2e-80 UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellul... 301 2e-80 UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Coryneba... 297 4e-79 UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actin... 296 6e-79 UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actin... 296 8e-79 UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax... 295 2e-78 UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Haloba... 294 3e-78 UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=C... 292 1e-77 UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocar... 292 1e-77 UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosy... 290 5e-77 UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubro... 290 7e-77 UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=C... 289 8e-77 UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseud... 289 1e-76 UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Strepto... 289 1e-76 UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax... 287 3e-76 UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Coryneb... 286 7e-76 UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyc... 285 2e-75 UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphapr... 282 1e-74 UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocu... 280 7e-74 UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobact... 277 3e-73 UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp... 272 1e-71 UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frank... 272 1e-71 UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenuli... 272 2e-71 UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomy... 269 1e-70 UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=C... 264 3e-69 UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudo... 255 2e-66 UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenuli... 252 1e-65 UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylob... 249 9e-65 UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseu... 248 2e-64 UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbell... 218 3e-55 UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74... 212 1e-53 UniRef50_Q31KY6 Glutamate--cysteine ligase, putative n=24 Tax=ce... 204 4e-51 UniRef50_B7K137 Glutamate/cysteine ligase n=9 Tax=Cyanobacteria ... 202 2e-50 UniRef50_Q2BQQ6 Putative uncharacterized protein n=1 Tax=Neptuni... 201 4e-50 UniRef50_P46309 Glutamate--cysteine ligase, chloroplastic n=133 ... 201 4e-50 UniRef50_A0YFA7 Putative uncharacterized protein n=2 Tax=unclass... 199 1e-49 UniRef50_Q2JXJ9 Glutamate-cysteine ligase, family 2 n=7 Tax=Bact... 197 4e-49 UniRef50_Q6Z3A3 Glutamate--cysteine ligase B, chloroplastic n=81... 193 1e-47 UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verru... 192 2e-47 UniRef50_B8KSF5 Glutamate-cysteine ligase, family 2 n=2 Tax=uncl... 191 3e-47 UniRef50_A4RZD5 Gamma-glutamate cysteine synthase n=2 Tax=Viridi... 189 1e-46 UniRef50_A9TJF8 Predicted protein n=1 Tax=Physcomitrella patens ... 187 5e-46 UniRef50_C6MEH3 Putative uncharacterized protein n=1 Tax=Nitroso... 185 2e-45 UniRef50_Q2SQ10 Uncharacterized conserved protein n=2 Tax=Gammap... 184 3e-45 UniRef50_Q39ZU6 Gamma-glutamylcysteine synthetase n=1 Tax=Peloba... 181 4e-44 UniRef50_C8NRE4 Family 2 glutamate-cysteine ligase n=11 Tax=Acti... 180 7e-44 UniRef50_B1KDI6 CBS domain containing protein n=1 Tax=Shewanella... 180 8e-44 UniRef50_B0S3P4 Glutamate-cysteine ligase n=2 Tax=Finegoldia mag... 179 2e-43 UniRef50_A1ZDC2 CBS domain pair protein n=1 Tax=Microscilla mari... 178 2e-43 UniRef50_Q092K6 Glutamate--cysteine ligase n=2 Tax=Cystobacterin... 178 2e-43 UniRef50_A2BYV9 Uncharacterized conserved protein n=7 Tax=Prochl... 178 4e-43 UniRef50_C7RFC6 Glutamate--cysteine ligase n=3 Tax=Anaerococcus ... 177 4e-43 UniRef50_D0LNP6 CBS domain containing membrane protein n=3 Tax=M... 177 5e-43 UniRef50_D0I9T0 Putative uncharacterized protein n=1 Tax=Grimont... 177 5e-43 UniRef50_B4S4M7 Putative uncharacterized protein n=7 Tax=Chlorob... 177 5e-43 UniRef50_Q5FPI3 Glutamate--cysteine ligase n=1 Tax=Gluconobacter... 177 8e-43 UniRef50_D1R9R1 Putative uncharacterized protein n=1 Tax=Parachl... 175 3e-42 UniRef50_Q1DCU0 Glutamate-cysteine ligase, family 2 n=2 Tax=Myxo... 173 1e-41 UniRef50_D0MH09 CBS domain containing protein n=1 Tax=Rhodotherm... 172 2e-41 UniRef50_A3ZWT8 Putative uncharacterized protein n=1 Tax=Blastop... 172 2e-41 UniRef50_B9ZKM7 Putative uncharacterized protein n=1 Tax=Thioalk... 172 2e-41 UniRef50_B5ZRA7 Glutamate/cysteine ligase n=8 Tax=Rhizobium RepI... 171 3e-41 UniRef50_Q2S261 CBS domain pair protein n=1 Tax=Salinibacter rub... 170 7e-41 UniRef50_B9TDX9 Putative uncharacterized protein (Fragment) n=1 ... 170 7e-41 UniRef50_C1B0M2 Putative uncharacterized protein n=2 Tax=Rhodoco... 170 8e-41 UniRef50_Q11LE8 Glutamate--cysteine ligase n=22 Tax=Alphaproteob... 169 1e-40 UniRef50_C4DKI0 Putative uncharacterized protein n=1 Tax=Stackeb... 169 1e-40 UniRef50_D0L3Q4 Glutamate--cysteine ligase, GCS2 n=78 Tax=Actino... 169 1e-40 UniRef50_C8QVM0 Glutamate--cysteine ligase GCS2 n=1 Tax=Desulfur... 166 1e-39 UniRef50_C6XGY1 Glutamate--cysteine ligase n=2 Tax=Rhizobiaceae ... 166 1e-39 UniRef50_D2AYM1 Glutamate-cysteine ligase, family 2 n=2 Tax=Bact... 165 2e-39 UniRef50_Q4FMS2 Glutamate-cysteine ligase family 2(GCS2) n=2 Tax... 165 3e-39 UniRef50_B6BSN8 Glutamate-cysteine ligase family 2 protein n=2 T... 165 3e-39 UniRef50_A1WVT1 Glutamate--cysteine ligase, GCS2 n=2 Tax=Ectothi... 163 1e-38 UniRef50_D2L0B8 Glutamate--cysteine ligase GCS2 n=2 Tax=Desulfov... 162 2e-38 UniRef50_C0N7Q3 Putative uncharacterized protein n=1 Tax=Methylo... 161 4e-38 UniRef50_Q9JMV4 Putative glutathione synthetase GshA (Fragment) ... 160 8e-38 UniRef50_A1K6A6 Glutamate-cysteine ligase n=5 Tax=Proteobacteria... 159 1e-37 UniRef50_C7NI09 Putative uncharacterized protein n=1 Tax=Kytococ... 159 1e-37 UniRef50_A4CI62 CBS domain pair protein n=2 Tax=Flavobacteriales... 159 2e-37 UniRef50_B7AQN9 Putative uncharacterized protein n=1 Tax=Bactero... 159 2e-37 UniRef50_D0LKS0 Glutamate--cysteine ligase n=1 Tax=Haliangium oc... 158 3e-37 UniRef50_UPI0001AEDC74 hypothetical protein SalbJ_18393 n=1 Tax=... 158 4e-37 UniRef50_A6GCK2 Glutamate--cysteine ligase n=1 Tax=Plesiocystis ... 157 5e-37 UniRef50_B2HGM5 Putative uncharacterized protein n=3 Tax=Mycobac... 157 6e-37 UniRef50_D0WIV7 Putative glutamate--cysteine ligase n=1 Tax=Slac... 155 3e-36 UniRef50_A7HH96 Glutamate--cysteine ligase n=5 Tax=Cystobacterin... 155 3e-36 UniRef50_D0RQE4 Glutamate--cysteine ligase, (Gamma-glutamylcyste... 154 4e-36 UniRef50_C9RNX1 Glutamate--cysteine ligase GCS2 n=1 Tax=Fibrobac... 154 5e-36 UniRef50_D1PL70 Putative glutamate--cysteine ligase n=1 Tax=Subd... 152 2e-35 UniRef50_A9GBM5 Glutamate--cysteine ligase n=1 Tax=Sorangium cel... 151 4e-35 UniRef50_C8WKE9 Glutamate--cysteine ligase n=2 Tax=Coriobacteria... 150 9e-35 UniRef50_C4GD43 Glutamate--cysteine ligase n=1 Tax=Shuttleworthi... 150 1e-34 UniRef50_D1ACB6 Glutamate/cysteine ligase family protein n=2 Tax... 147 6e-34 UniRef50_A7I8T0 Glutamate--cysteine ligase, GCS2 n=6 Tax=Euryarc... 146 9e-34 UniRef50_Q5ZYJ4 AF2307 n=4 Tax=Legionella pneumophila RepID=Q5ZY... 146 2e-33 UniRef50_A6TWY9 Glutamate--cysteine ligase n=2 Tax=Alkaliphilus ... 144 4e-33 UniRef50_UPI00016C5767 glutamate--cysteine ligase n=1 Tax=Gemmat... 141 4e-32 UniRef50_A0M1L9 GCS2 glutamate--cysteine ligase n=3 Tax=Flavobac... 140 7e-32 UniRef50_O27977 Uncharacterized protein AF_2307 n=2 Tax=Archaeog... 138 3e-31 UniRef50_D2RSK6 Putative uncharacterized protein n=1 Tax=Haloter... 135 2e-30 UniRef50_C0EWU2 Putative uncharacterized protein n=1 Tax=Eubacte... 135 3e-30 UniRef50_B1MFR8 Glutamate--cysteine ligase GshA n=1 Tax=Mycobact... 133 1e-29 UniRef50_C8XBM8 Glutamate/cysteine ligase family protein n=1 Tax... 132 2e-29 UniRef50_C7ML88 Gamma-glutamylcysteine synthetase n=1 Tax=Crypto... 132 3e-29 UniRef50_A8M1F4 Glutamate--cysteine ligase GCS2 n=2 Tax=Salinisp... 131 4e-29 UniRef50_B2A6L2 Glutamate--cysteine ligase n=1 Tax=Natranaerobiu... 130 1e-28 UniRef50_D1X937 Glutamate/cysteine ligase family protein n=11 Ta... 130 1e-28 UniRef50_B9LUZ8 Putative uncharacterized protein n=8 Tax=Halobac... 129 1e-28 UniRef50_C7NPM2 Glutamate--cysteine ligase GCS2 n=4 Tax=Halobact... 129 2e-28 UniRef50_Q8TY80 Predicted metal-dependent hydrolase of the TIM-b... 129 2e-28 UniRef50_Q6ANW2 Glutathione synthetase n=1 Tax=Desulfotalea psyc... 128 3e-28 UniRef50_D2B0V7 Glutamate/cysteine ligase n=1 Tax=Streptosporang... 128 4e-28 UniRef50_B4V5Z6 Glutamate-cysteine ligase n=10 Tax=Streptomyces ... 127 5e-28 UniRef50_B4VPR5 Glutamate-cysteine ligase family 2 n=1 Tax=Micro... 127 5e-28 UniRef50_UPI0001C36E32 Glutathione synthase n=1 Tax=Ruminococcus... 127 7e-28 UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanoc... 126 9e-28 UniRef50_D1REB2 Carboxylate-amine ligase-like protein n=1 Tax=Le... 126 1e-27 UniRef50_C7MXH6 Gamma-glutamylcysteine synthetase n=2 Tax=Actino... 123 1e-26 UniRef50_A4FGC2 Glutamate-cysteine ligase n=3 Tax=Actinomycetale... 123 1e-26 UniRef50_B0KFE7 Methyltransferase small n=1 Tax=Pseudomonas puti... 122 3e-26 UniRef50_D1VG95 Glutamate/cysteine ligase family protein n=1 Tax... 119 2e-25 UniRef50_A1A2R1 Possible glutamate--cysteine ligase n=18 Tax=Bif... 117 7e-25 UniRef50_B4WP90 Putative uncharacterized protein n=3 Tax=Cyanoba... 117 8e-25 UniRef50_D2RU12 Glutamate--cysteine ligase GCS2 n=1 Tax=Haloterr... 116 1e-24 UniRef50_A4T5Z6 Glutamate--cysteine ligase, GCS2 n=28 Tax=Actino... 115 3e-24 UniRef50_B9ZBA6 Glutamate--cysteine ligase GCS2 n=1 Tax=Natrialb... 114 5e-24 UniRef50_C3JX20 Glutamate--cysteine ligase family protein n=5 Ta... 113 1e-23 UniRef50_D2RUA3 Putative uncharacterized protein n=1 Tax=Haloter... 111 5e-23 UniRef50_D2RSM6 Putative uncharacterized protein n=1 Tax=Haloter... 108 4e-22 UniRef50_D2RRB5 Glutamate--cysteine ligase GCS2 n=2 Tax=Haloterr... 106 1e-21 UniRef50_D1N7M9 Glutathione synthase n=1 Tax=Victivallis vadensi... 106 2e-21 UniRef50_Q0RAS7 Glutamate--cysteine ligase GSHA (Gamma-glutamylc... 103 1e-20 UniRef50_C1DH93 Glutamate-cysteine ligase-like protein n=1 Tax=A... 102 3e-20 UniRef50_D2MHE8 Putative uncharacterized protein n=1 Tax=Candida... 99 1e-19 UniRef50_C4RDQ5 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromono... 100 2e-19 UniRef50_Q1WVP8 Glutamate--cysteine ligase n=12 Tax=Lactobacillu... 98 5e-19 UniRef50_C7QH01 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenuli... 97 8e-19 UniRef50_Q8XK30 Glutathione synthetase n=11 Tax=Bacteria RepID=G... 95 3e-18 UniRef50_Q127I4 Glutamate--cysteine ligase n=18 Tax=cellular org... 95 4e-18 UniRef50_Q8YYX1 All0721 protein n=4 Tax=Nostocaceae RepID=Q8YYX1... 92 5e-17 UniRef50_Q2RLA4 Putative uncharacterized protein n=1 Tax=Moorell... 91 8e-17 UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilu... 90 2e-16 UniRef50_Q03Q55 Glutamate--cysteine ligase n=1 Tax=Lactobacillus... 88 7e-16 UniRef50_C0W6H8 Putative uncharacterized protein n=1 Tax=Actinom... 73 1e-11 Sequences not found previously or not previously below threshold: UniRef50_B2SNT5 Glutamate--cysteine ligase n=3 Tax=Xanthomonas o... 150 8e-35 UniRef50_A8UG36 CBS domain pair protein n=1 Tax=Flavobacteriales... 137 6e-31 UniRef50_C7HWJ1 Putative uncharacterized protein n=1 Tax=Anaeroc... 120 9e-26 UniRef50_B8CWC8 Glutamate--cysteine ligase n=1 Tax=Halothermothr... 117 6e-25 UniRef50_B6W6Y7 Putative uncharacterized protein n=1 Tax=Anaeroc... 113 1e-23 UniRef50_B1CBH9 Putative uncharacterized protein n=1 Tax=Anaerof... 108 3e-22 UniRef50_C3R5G2 Glutathione biosynthesis gshAB n=1 Tax=Bacteroid... 98 6e-19 UniRef50_B7BHE3 Glutamate--cysteine ligase (Fragment) n=1 Tax=Pa... 94 9e-18 UniRef50_C7P329 Putative uncharacterized protein n=2 Tax=Halobac... 91 7e-17 UniRef50_Q18FX4 Putative uncharacterized protein n=2 Tax=Halobac... 90 2e-16 UniRef50_UPI0000382CE6 COG3572: Gamma-glutamylcysteine synthetas... 90 2e-16 UniRef50_Q97IV1 Glutamate--cysteine ligase n=2 Tax=Clostridium R... 88 3e-16 UniRef50_C2ZI28 Glutathione synthetase n=10 Tax=Bacilli RepID=C2... 88 4e-16 UniRef50_C2C3Y2 Bifunctional glutamate--cysteine ligase/glutathi... 88 4e-16 UniRef50_Q65RX0 Glutathione synthetase n=83 Tax=Bacteria RepID=G... 88 7e-16 UniRef50_C4DSG7 Gamma-glutamylcysteine synthetase n=1 Tax=Stacke... 86 2e-15 UniRef50_B1MW57 Glutamate--cysteine ligase n=3 Tax=Leuconostoc R... 86 3e-15 UniRef50_A0AMA3 Glutathione synthetase n=15 Tax=Bacilli RepID=GS... 84 8e-15 UniRef50_UPI0001C418FC bifunctional glutamate-cysteine ligase/gl... 84 9e-15 UniRef50_C5R9H8 Glutamate--cysteine ligase n=1 Tax=Weissella par... 83 2e-14 UniRef50_Q15W46 Glutamate--cysteine ligase n=1 Tax=Pseudoalterom... 81 7e-14 UniRef50_Q8DW15 Glutathione synthetase n=7 Tax=Streptococcus Rep... 80 1e-13 UniRef50_Q38XD9 Putative glutamate-cysteine ligase n=1 Tax=Lacto... 80 2e-13 UniRef50_Q48PX1 Glutamate--cysteine ligase n=86 Tax=Proteobacter... 78 6e-13 UniRef50_Q21SH8 Glutamate--cysteine ligase n=1 Tax=Rhodoferax fe... 78 7e-13 UniRef50_Q21EP1 Glutamate--cysteine ligase n=2 Tax=Gammaproteoba... 77 1e-12 UniRef50_Q0AVA1 Gamma-glutamylcysteine synthetase-like protein n... 77 1e-12 UniRef50_C0WQG0 Glutamate--cysteine ligase n=3 Tax=Lactobacillus... 76 2e-12 UniRef50_B8GMF6 Glutamate--cysteine ligase n=1 Tax=Thioalkalivib... 76 2e-12 UniRef50_B8I2B6 Glutamate--cysteine ligase n=2 Tax=Clostridium R... 76 2e-12 UniRef50_A5EXD0 Glutamate--cysteine ligase n=2 Tax=Cardiobacteri... 75 3e-12 UniRef50_Q2NGX6 GshA n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 75 3e-12 UniRef50_C2CYS8 Glutamate--cysteine ligase n=3 Tax=Lactobacillus... 75 3e-12 UniRef50_C0XJ04 Glutamate--cysteine ligase n=3 Tax=Lactobacillus... 75 4e-12 UniRef50_C1DJH1 Glutamate--cysteine ligase n=4 Tax=Gammaproteoba... 74 7e-12 UniRef50_D1VQH9 Glutamate/cysteine ligase family protein n=1 Tax... 74 8e-12 UniRef50_C6VI68 Glutamate--cysteine ligase n=4 Tax=Lactobacillus... 73 1e-11 UniRef50_A5LRB7 Glutamyl-tRNA synthetase n=36 Tax=Streptococcus ... 73 2e-11 UniRef50_B3PGB0 Glutamate--cysteine ligase n=3 Tax=Gammaproteoba... 73 2e-11 >UniRef50_A0YLQ7 Putative uncharacterized protein n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YLQ7_9CYAN Length = 371 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 100/363 (27%), Positives = 175/363 (48%), Gaps = 2/363 (0%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 E TLG+E E Q+++P LS +I + V+ ++ +S +E+AT VC+ + Sbjct: 5 EGLTLGVEEEYQIIDPKTRQLSGRGEKIISFAEENYGKEIVQPEMHKSQIEIATSVCKSL 64 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + + S +++V++AA + I THPF W++QE N RYQ+ + + ++++ Sbjct: 65 AEVRSELSEARRIVIEAAQRDNKAIAAAATHPFSHWKQQETTANFRYQKLEQEYQQILRE 124 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 FG HVHVG + AI +++ ++ +ALSA SP+ G T + S R ++S F Sbjct: 125 LVTFGCHVHVGIEDKEVAIAVINRARMWLSVLLALSANSPFWLGKKTGYISYRTELWSPF 184 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G P +++ ++ L +I ++W+IR S H+ T+E RV D LT+ Sbjct: 185 PLFGSPPVFEDYKAYQNFVEQLIKMEVIQDTTTIYWNIRISEHYPTIEFRVSDICLTVDE 244 Query: 250 AVNMAGLIQATAHWLLTERPFKHQE--KDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV +AGL++ L E L K + A RYGL+G + D +P Sbjct: 245 AVMIAGLVRGLVQTCLIEIENDFPLIFVHPELLKTADWYAARYGLQGKLIDVMQQRSKPA 304 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 + + L + P+ +G + +L +V+ N AQ + G+++ +V E Sbjct: 305 KDLVKQFLNYVRPALESLGDWEEVSSLVDKVLKHGNAAQRQLEIYQRQGNIVEVVDYLVE 364 Query: 368 IWA 370 Sbjct: 365 QTR 367 >UniRef50_B4WGF8 Uncharacterized enzyme subfamily n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WGF8_9SYNE Length = 377 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 103/367 (28%), Positives = 171/367 (46%), Gaps = 2/367 (0%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + FT+G+E E Q+V+P L+ S LI +N T E+ H++ +E+AT +C Sbjct: 1 MVPDFTIGVEEEYQIVDPETRSLADCSKSLIKTNQNSNTEQEIVHELFRCEVEIATGICH 60 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 ++ + V++AA D+ I GTHPF W+ QEV ERY E+ +I Sbjct: 61 TLDDVRRALVQARTAVIEAAQDNGAVIAAAGTHPFSPWEEQEVTPKERYYALQEDLQQII 120 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ + G HVHVG + A+ + + ++P ++L+A SP+ G DT + S R ++ Sbjct: 121 KELIILGCHVHVGVEDREMAVQISNRARIWLPLLLSLTANSPFCDGKDTGYDSYRMALWC 180 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 P GP P+ N+ ++ + L T + D ++WDIR S F T+E R+ D ++ Sbjct: 181 RLPTAGPPPFFENYADYQGFIQKLIDTDITDDPTKVYWDIRLSERFPTIEFRMSDVCASI 240 Query: 248 SHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 AV +AG+I+A A+ + + K +QA R+GL G + D T + Sbjct: 241 EEAVMLAGIIRALAYTCYQDVINGQPALPVRGEMLKAAMWQAARHGLSGELIDFATTESV 300 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P + I P G + ++ +++S N AQ R SL +V Sbjct: 301 PAKTLVQSFMRYIQPGLAHFGDEAIVKKEVDKILSEGNSAQRQRAVYEKTSSLESVVDDI 360 Query: 366 CEIWAGD 372 A Sbjct: 361 VRRSAMQ 367 >UniRef50_A4W7T6 Carboxylate-amine ligase Ent638_1085 n=111 Tax=Bacteria RepID=CAAL_ENT38 Length = 373 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 286/370 (77%), Positives = 329/370 (88%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 MPLPDFH S+PFTLGIELE+QVVNPPGYDLSQDSS LI AVKN I AGEVKHDITESMLE Sbjct: 1 MPLPDFHSSDPFTLGIELELQVVNPPGYDLSQDSSALIAAVKNDIKAGEVKHDITESMLE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +AT VC++I+QAA QFSAMQ+ +L+AA D H++I GGGTHPFQKWQRQEVCD+ERY L Sbjct: 61 IATGVCQNIDQAAAQFSAMQQAILRAAGDQHIQIAGGGTHPFQKWQRQEVCDDERYNHNL 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E FGYLI QATVFGQHVHVGC +GDDAIYLLHGLSRFVPHFIALSA+SPYMQG+DT+FAS Sbjct: 121 ELFGYLILQATVFGQHVHVGCRNGDDAIYLLHGLSRFVPHFIALSASSPYMQGSDTKFAS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR NIFS FPDNG MPWVSNWQ FE LFR LSYT+MID+IKD+HWDIRPSPHFGTVEVRV Sbjct: 181 SRLNIFSGFPDNGKMPWVSNWQGFEGLFRRLSYTSMIDTIKDVHWDIRPSPHFGTVEVRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 MDTPLTL+HA+N+AGLIQATAHWLLTERP+KHQE+DYLLYKFNRFQACRYGL+G++TD + Sbjct: 241 MDTPLTLAHAINIAGLIQATAHWLLTERPYKHQEQDYLLYKFNRFQACRYGLDGLLTDVN 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG+++ + ED LL+++APSA K+G +SAI + + G +EAQ MRDF+ADGGSLI Sbjct: 301 TGEQKTIAEDMKWLLDRVAPSAEKLGGASAIAEIALMLKQGKSEAQRMRDFIADGGSLIS 360 Query: 361 LVKKHCEIWA 370 LV+KHCE+WA Sbjct: 361 LVQKHCELWA 370 >UniRef50_Q7NI89 Carboxylate-amine ligase gll2294 n=1 Tax=Gloeobacter violaceus RepID=CAAL_GLOVI Length = 372 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 102/368 (27%), Positives = 184/368 (50%), Gaps = 5/368 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT-AGEVKHDITESML 59 M +P F S TLG+E+E+Q+++P +L+ L+ + VK ++ ++ + Sbjct: 1 MTIP-FQSSTAPTLGVEMELQIIDPATGNLTPRGPELVTFCEEHPEVGLVVKPELVQATI 59 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E+ T +C+D+ Q + ++ + + GTHPF +W+ + RY+ Sbjct: 60 EINTGICKDVAQVERDLTTQLTLLRSVCRERGVSFLSAGTHPFARWRERRYTQTPRYRAL 119 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 ++ + ++ ++G HVHVG GD AI +++ ++++ P +ALSA SP+ +G DT Sbjct: 120 VDKHVWTARRMQIYGLHVHVGMPDGDTAIQVINQITQYAPMLLALSANSPFWEGDDTGLD 179 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 S R +F G NW+ +E L L T I S +++ WDIRP FGT+EVR Sbjct: 180 SCRTKVFENLSSAGLPFRFENWEGYENLINVLLETGSIGSQREIWWDIRPHSDFGTIEVR 239 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 + D TL+ + + L+Q A + L E + + + + N+++ACR+GLEG + Sbjct: 240 ICDATRTLAEVLALTALVQCLAVYFRRLYENGEEIRLLHPGIIRENKWRACRWGLEGELI 299 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 DP T P + + + ++ A ++G S+ + A+ + S N A R + S Sbjct: 300 DPLTLKGVPTRKLIEQTVGEMQSLAAELGCSAYLAAIPAILAS-GNGATRQRRIYSQSRS 358 Query: 358 LIGLVKKH 365 L+ +V Sbjct: 359 LVAVVADL 366 >UniRef50_Q47LS4 Carboxylate-amine ligase Tfu_2565 n=6 Tax=Actinomycetales RepID=CAAL_THEFY Length = 399 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 117/374 (31%), Positives = 192/374 (51%), Gaps = 6/374 (1%) Query: 3 LPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA---GEVKHDITESML 59 +F+ S+ TLG+E E+Q+V+ L QD+ L++ + A ++H++ +S + Sbjct: 2 TIEFNPSKRATLGVEWELQLVDRDSGHLRQDAQKLLEELPELSGAESNPPLRHELMQSTI 61 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E+ T +C +++ SA + QAA +E+ GTHP W+ QE ++RY Sbjct: 62 EVVTGICETVDEVKEDLSATVARLTQAADGRGIELACAGTHPIDDWRDQEFAPSQRYSEL 121 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 +E +L ++ FG HVHVG D I +++ LSR++PHF+AL+A+SP+ G DT A Sbjct: 122 IEQMQWLARRILTFGVHVHVGVTDRDKVIPIVNALSRYLPHFLALTASSPFWSGHDTGLA 181 Query: 180 SSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 SSR +F A P GP P +++W FE L I SIK++ WDIRP P FGTVE+R Sbjct: 182 SSRSIVFGALPTAGPPPRLAHWGAFEEYMDTLLRAGTITSIKEVWWDIRPHPEFGTVEIR 241 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 + D T+ A L Q+ +R ++ + N+++A RYGL+ I Sbjct: 242 MFDGIPTVREVGMAAALSQSLVQLFEQQLDRGYRLPSPSSWVVTDNKWRATRYGLDARII 301 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 G PL +D LL ++ P A ++G + ++ + + G + + R + GG Sbjct: 302 IDERGSTVPLRDDLYELLHELRPIAERLGCAEDLDVVAEILHYGASY-ERQRAIIRQGGV 360 Query: 358 LIGLVKKHCEIWAG 371 L +V + + Sbjct: 361 LKDVVDALVKEFRA 374 >UniRef50_D2SG64 Glutamate--cysteine ligase GCS2 n=5 Tax=Actinomycetales RepID=D2SG64_9ACTO Length = 401 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 191/374 (51%), Gaps = 5/374 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESM 58 M +P F SE +LG+E E+Q+V+ L+ + +++ ++ + KH++ +S Sbjct: 1 MQIP-FRSSERASLGVEWELQLVDVRTRQLTAGAVEILEELRPEGAEEHPKAKHELLQST 59 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E+ T VC + +A + V AA L + GTHP WQ Q++ ERY + Sbjct: 60 VEVITGVCTTVAEAKADLAGTVAEVRAAAERRGLGLMCAGTHPITDWQTQQISPKERYLQ 119 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E +L ++ +FG HVHVG + + AI +++ L+++VPHF+ALSA+SP+ G DT Sbjct: 120 LVEKMQWLARRLQIFGVHVHVGVRAPEKAIPIVNALTQYVPHFLALSASSPFWVGCDTGL 179 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G +S W +FE L T I+S++++ WDIRP P FGTVE+ Sbjct: 180 ASARSKVFEGMPTAGLPYQLSGWDRFEEYMETLISTHAIESVREVWWDIRPHPDFGTVEL 239 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 R+ D TL +A L Q +R + + + N+++A RYGL+ I Sbjct: 240 RICDGLPTLDEIGAVAALSQCLVEQFDTQLDRGYTLPVPASWVLQENKWRAARYGLDADI 299 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 G RP+ + L+E++ P+A ++G + + +HR + G + + A G Sbjct: 300 VVDDKGTVRPVRQAITDLVEELEPTARRLGCEAELADVHRILAVGASYQRQRAVAAASDG 359 Query: 357 SLIGLVKKHCEIWA 370 L +V Sbjct: 360 DLTAVVDSLLAELR 373 >UniRef50_C1A844 Carboxylate-amine ligase n=3 Tax=Bacteria RepID=C1A844_GEMAT Length = 404 Score = 366 bits (939), Expect = 1e-99, Method: Composition-based stats. Identities = 100/366 (27%), Positives = 164/366 (44%), Gaps = 6/366 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + T+GIE E Q+++P DL+ L+ +VK ++ + +E+ T VC Sbjct: 2 RTPSLTVGIEEEYQIIDPVTRDLTPGFDALVT--SEDAQLADVKAELHQCQVEIGTKVCS 59 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 I++ + ++ +V++AA H L I GTHPF W QE+ ERY L Sbjct: 60 SISELRTELVKLRGLVIKAAAQHGLTIASAGTHPFSNWMNQEMTPKERYLGVKAELQDLA 119 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + +FG HVHVG + I L+ +PH + LS +SP+ G +T S R +F Sbjct: 120 HRLLIFGTHVHVGIEDPEFRIDCLNASRYILPHILCLSTSSPFWFGRNTGLHSYRSIVFK 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 FP G ++ W + L L T I + WD+RP H+ T+E RV D + Sbjct: 180 NFPRTGVPRILNGWGDYADLVDTLQKTRSIPDGSKVWWDVRPHHHYPTLEFRVCDVNTRV 239 Query: 248 SHAVNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 AV +A ++QA W L + L + N+++A R+GL G + D + Sbjct: 240 DEAVCIAAILQAVVAKMWKLRRDNLTFRVYASDLIEENKWRAVRWGLGGKLIDFGKKEEL 299 Query: 306 PLTEDTLRLLEK-IAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P + L+E + ++G +E + +++ + AQ A G L +V + Sbjct: 300 PASVLIRELVEWFLDDVLDELGTRKEVEYAY-RILEEGSSAQRQLATYARTGDLRAVVDQ 358 Query: 365 HCEIWA 370 A Sbjct: 359 LIRETA 364 >UniRef50_Q1B017 Carboxylate-amine ligase Rxyl_0030 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL1_RUBXD Length = 376 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 102/370 (27%), Positives = 172/370 (46%), Gaps = 2/370 (0%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 MP+ + +TLG+E E+ +V+ +L ++ + + A V +++ +S+LE Sbjct: 1 MPVEFKLGNSGYTLGVEEELCIVDASTGELVPKIEEIMSRLPEDL-AEAVSYELFQSVLE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + T VCR + +A ++ V + GTHPF +++ Q+V ++ERY++ + Sbjct: 60 IKTPVCRTVGEAERVLRELRGRVGSWTAACGASLASAGTHPFSRYRDQKVTEHERYRQVI 119 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E ++ + +FGQHVHV ++AI + L+ P +ALSA SPY QG DT F S Sbjct: 120 EELRWVATREVIFGQHVHVAVPGPEEAIQAHNRLAEQAPLLLALSANSPYWQGMDTGFES 179 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR IF FP G P + FEA + +D WD+RP P GT+E+RV Sbjct: 180 SRVQIFETFPRAGMPPAFPEYAAFEAYVDLMVECGAMDDYTFCWWDVRPHPKLGTIELRV 239 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 +D+ L HAV + L Q L + + N+++A R GL+ D Sbjct: 240 LDSQTHLRHAVALTALTQCIVASSLEDEDAPKGPYHRDIALENKWRASRRGLDAAFFDVD 299 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P + +E++ P A ++G + + V G + ++ R+ G + Sbjct: 300 ERRNVPARDLARAAVERLRPHAQQLGCEEELLGVLEIV-EGGSGSRRQREIYEKSGDFLD 358 Query: 361 LVKKHCEIWA 370 +V E Sbjct: 359 VVAFLIEGTR 368 >UniRef50_Q6MKW4 Carboxylate-amine ligase Bd2263 n=1 Tax=Bdellovibrio bacteriovorus RepID=CAAL_BDEBA Length = 378 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 109/377 (28%), Positives = 199/377 (52%), Gaps = 8/377 (2%) Query: 1 MPLP---DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITES 57 M P F S+ F+LG+E+E+Q+++P +L S +++ + + +K ++ +S Sbjct: 1 MTKPQPIPFGKSDLFSLGVEVELQIIHPETRNLFPISPDILEE--WSLQSPHLKPEVFQS 58 Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 MLE+ T +C+++ + + + +L+ H + GTHPF KW + ++RY+ Sbjct: 59 MLEIDTPICKNVQEVEYELLLTSRELLRICKKHGARLASNGTHPFAKWHHRIFYPSDRYE 118 Query: 118 RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 LE ++ ++ ++G HVH+G GD I +++ ++PH +A+SA+SP+ G DT Sbjct: 119 YLLERNQHIARRLMIYGLHVHLGMKDGDHCIAMMNEFLYYLPHMLAMSASSPFWTGHDTG 178 Query: 178 FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVE 237 ASSR +F A P G V NW QFE + + L+ + I S KD+ WDIRPSP++GT+E Sbjct: 179 LASSRITVFEAHPAGGTPCRVENWAQFEDIVQKLTRSNSIGSFKDIWWDIRPSPNYGTLE 238 Query: 238 VRVMDTPLTLSHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +R+ D + + I A L E+ + Q D + + N+++A R+GL+ Sbjct: 239 IRICDGVPGIRKTTRLVAFIHLLAKHLQKRLEQGIRRQTPDDWMVRENKWRASRHGLDCE 298 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + + G + L ED LL + A ++G + ++ L + ++ + ++ R Sbjct: 299 VLIDNDGMTKNLREDIKDLLAAMKEDAAEMGYTEYLKQLVEEDLTHPSY-EIQRALFEKT 357 Query: 356 GSLIGLVKKHCEIWAGD 372 GSL +V C+++ D Sbjct: 358 GSLEHVVDSLCDVFEKD 374 >UniRef50_A9WAH5 Carboxylate-amine ligase Caur_3581 n=16 Tax=Bacteria RepID=CAAL_CHLAA Length = 390 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 103/361 (28%), Positives = 167/361 (46%), Gaps = 4/361 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 FTLGIE E Q+V+P +L + +++ I ++K ++ +S++E+ T CR I+ Sbjct: 12 AFTLGIEEEYQIVDPETRELRSYITQILEP-GRTILREQIKPEMHQSIVEVGTRPCRTIS 70 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A + ++ + A H+L I GTHPF W +QE+ +ERY + Q Sbjct: 71 EARAEIVRLRSAIAGLAARHNLRIVAAGTHPFSSWMQQEITPDERYHMVVGEMQDAALQL 130 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 +FG H H+G + + AI L++ PH +ALS +SP+ G +T F S R IFS FP Sbjct: 131 LIFGMHCHIGMPNNEVAIELMNVARYICPHLLALSTSSPFWMGRNTGFKSYRSVIFSTFP 190 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G P + +FE + L T ID+ K + WD+RP P FGT+E RV D + Sbjct: 191 RTGIPPTFHSASEFERYVQLLVNTGCIDNGKKIWWDLRPHPFFGTLEFRVCDIATKVEEC 250 Query: 251 VNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A +QA + E + L N+++A R+GL+G + D Sbjct: 251 LALAATMQALIVKFYTMFEENTTFRVYRRALINENKWRAQRWGLDGKLIDFGKRKEVEAK 310 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 ++E + +G+ +E L + V A A+ L +V Sbjct: 311 ALVHEIVELVDDVVDMLGSRREVEYLLKIV-ENGTSADRQLRVFAETNDLKAVVDNLMVE 369 Query: 369 W 369 Sbjct: 370 T 370 >UniRef50_D0L2A3 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0L2A3_GORB4 Length = 379 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 112/373 (30%), Positives = 177/373 (47%), Gaps = 5/373 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA--GEVKHDITESM 58 +P F S +LG+E E + + DLS ++ L AV+ + G+V ++ + Sbjct: 4 IPSIPFRGSPTPSLGVEWEFALTDKQSGDLSNSAAALFAAVEQRHPEHAGQVHKELLRNT 63 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +EL T VCR +A S VV A + +++ G GTHPF +W Q + + RY Sbjct: 64 VELVTGVCRTTAEALDDLSGTLGVVRGIADELGVDLYGAGTHPFAEWSTQLLTEGHRYAE 123 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 +E + +Q ++G HVHVG + D + +L L + PH +A+SA+SP G DT + Sbjct: 124 LIERTQWWGRQMLIWGVHVHVGISHRDKVLPILDALLNYYPHLLAISASSPMWAGQDTGY 183 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS+R +F P G + W +FE+ T +ID + ++ WDIRPSPH GT+EV Sbjct: 184 ASNRAMMFQQLPTAGLPFQFARWDEFESFVADQKTTGIIDHLNEIRWDIRPSPHLGTIEV 243 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 RV D L LI L E L + N+++A RYGL+ ++ Sbjct: 244 RVCDGMTNLRELSAAVALIHCLVVDLDRRLEAGETLPTMAPWLVQENKWRAARYGLDAIV 303 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 R +TED +L+++AP A + + + + SG + Q R A GG Sbjct: 304 ITDGNCAERLVTEDLAGVLDRLAPIARDLDCIDELAGVTSIIESGGSY-QRQRAVHAGGG 362 Query: 357 SLIGLVKKHCEIW 369 ++ +V Sbjct: 363 TMRDVVASVVGEL 375 >UniRef50_D1RC58 Carboxylate-amine ligase-like protein n=3 Tax=Legionella RepID=D1RC58_LEGLO Length = 402 Score = 363 bits (932), Expect = 7e-99, Method: Composition-based stats. Identities = 107/366 (29%), Positives = 184/366 (50%), Gaps = 6/366 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F+ TLG+E+E+Q+++ Y+L + ++ A+ + ++K + S +E+ T+ Sbjct: 27 FNSGGVLTLGVEIELQLIDAETYNLCSRAEDILAAMSHL---EKIKPEFYLSTIEVNTNK 83 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C + + A + + + + G+HPF K+ E+ RY ++ + Sbjct: 84 CGSVQEVEDDLYATLFELQHVSKKLGILLSTTGSHPFSKYCDWEISPTARYLDLIDRNQW 143 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 L ++ +V+G HVH+G +SG++ I + F+PH +ALS++SP+ QG DT AS RP Sbjct: 144 LTRRMSVYGLHVHLGMSSGEECIRFNNFFMYFLPHLLALSSSSPFWQGIDTGLASCRPTT 203 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 + A P G V +WQ FE L++ L I S+KDL WD+RPSP+FGT+E+RV D Sbjct: 204 YEALPTAGQPYHVRSWQDFEHLYKTLKSCGSIKSLKDLWWDLRPSPNFGTLEIRVCDGTA 263 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQE--KDYLLYKFNRFQACRYGLEGVITDPHTGD 303 TL+ + + LI A AHW + Y L + N+++A RYGL+ + G Sbjct: 264 TLAETLALVALIHALAHWFADNGSWLESVAYPPYWLSRENKWRAIRYGLDAELVMNTEGK 323 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 + + ED +EK+ P ++ + L + SG + + R S +VK Sbjct: 324 IKLMREDINEWIEKLKPYIEQLNYQTYFATLQSIMSSGTST-ERQRKVFTYNKSFKDVVK 382 Query: 364 KHCEIW 369 + + Sbjct: 383 HNVSEF 388 >UniRef50_D2NRT8 Uncharacterized conserved protein n=2 Tax=Rothia mucilaginosa RepID=D2NRT8_9MICC Length = 394 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 100/378 (26%), Positives = 168/378 (44%), Gaps = 11/378 (2%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA--------GEVKHDIT 55 DF S TLG+E E+ +++ +L+Q + ++ ++ + V + Sbjct: 14 IDFASSPQSTLGVEWEIALIDRESGELTQRAGEVLSILRERRPELLEPASDRAHVTGEFL 73 Query: 56 ESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNER 115 E+ +E+ T +C + +A Q + ++ + D +E GTHPF W Q V ER Sbjct: 74 ENTIEVVTGICHTVAEACRQLQELTDIIREITDDLGIEFYPAGTHPFSHWADQPVVAKER 133 Query: 116 YQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD 175 YQR +E Y + ++G HVHVG S D + L+ L+ + PH +ALS +SPY G D Sbjct: 134 YQRVVERAQYWGRHMVIYGVHVHVGVDSRDKVLPLIDALTNYGPHLLALSCSSPYWDGID 193 Query: 176 TRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGT 235 T +AS R ++ P NG W+Q+ L T +I+ + WD+RP P +GT Sbjct: 194 TGYASHRTQLYQQLPTNGLPFHFDTWEQYSEYLDSLVATDVINDPSEDRWDVRPVPRYGT 253 Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLE 293 +E+R D +L + Q + E + + N+++ RYGL+ Sbjct: 254 IEMRYCDGLASLPDVAAIVAFTQCLVEYFSRQVEAGESIEVLAPWHAQENKWRVARYGLD 313 Query: 294 GVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA 353 I + ++R L ED LL K+ P A + + + R++++ A R Sbjct: 314 AKIVVSNAPEQRTLREDFELLLPKLEPVARDLDCEVELAQV-RRILAEGTGADRQRAVFE 372 Query: 354 DGGSLIGLVKKHCEIWAG 371 GSL + Sbjct: 373 KTGSLREVALDVAVQSRA 390 >UniRef50_B0REM7 Carboxylate-amine ligase CMS0754 n=6 Tax=Actinomycetales RepID=CAAL_CLAMS Length = 383 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 102/371 (27%), Positives = 182/371 (49%), Gaps = 3/371 (0%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 DF P +GIE E+ V+ +L+ + ++ + + V + + +E+ + Sbjct: 9 IDFARQPPSRVGIEWELACVDRGSGELAGVAPQILRSFPHDDAHPHVTGEFLTNTVEVVS 68 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCD-NERYQRTLEN 122 + A + + + V+ A +++ GTHPF W Q+V NERY L+ Sbjct: 69 APHSRVGHAVDDLARLIERVVDVADPLGIDLMCAGTHPFSAWPDQDVTPDNERYATLLDR 128 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 + +Q ++G HVHVG G A+ +L+ L +P F ALSA+SP+ G +T +AS+R Sbjct: 129 TRWWGRQMMIWGVHVHVGIEDGSKALPILNALLVHLPRFQALSASSPFWSGQETGYASNR 188 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 +F P G P ++ W +E L +++ +ID +L WDIRP+P +GT+E RV D Sbjct: 189 ALMFQQLPTAGLPPDLTTWADYERLIGDMTHVGVIDHHSELRWDIRPAPKWGTLETRVFD 248 Query: 243 TPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 TL ++A L+Q H L +R + + N+++A RYG++ +I Sbjct: 249 GVSTLGEIASLAALVQCLVHDLSAALDRGEELPRMQPWFVRENKWRAARYGMDAIIIQDA 308 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 G+ + +DT L+E+++P+A +G + + + V G + + +R + G+L Sbjct: 309 AGEEALVGDDTRALVERLSPTADALGCEAELRGILDIVDRGASYQRQLRVAEENDGALAP 368 Query: 361 LVKKHCEIWAG 371 +V E Sbjct: 369 VVTHLVEELRS 379 >UniRef50_C3JMG1 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JMG1_RHOER Length = 382 Score = 361 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 88/370 (23%), Positives = 159/370 (42%), Gaps = 6/370 (1%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P PD TLG+E E + +P + ++ + A + ++ ++T +E Sbjct: 5 PTPDIFSVGTPTLGVEEEFLLCDPQTGRPTLRNAEV--AAAGRELGISLQLELTRCQVET 62 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 +T + I Q + V AA ++ GT PF E+ RYQR Sbjct: 63 STSIGSHIRDLRDQLCESRAVTADAAARVGCQLIAVGT-PFYDPPVDEITQTSRYQRMAG 121 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 FG + + + G H+HVG + ++ +++ L ++P +AL+A SP G DT +AS Sbjct: 122 QFGAI-TEGVMCGCHIHVGVEDRERSVQIINHLRPWLPTLLALTANSPISAGRDTGYASW 180 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R +F +P +GP P + +E + T +I ++WD+R S H TVE+R+ Sbjct: 181 RYVLFGRWPSSGPPPCFESVAHYEDAVAAMLETGVILDPHMVYWDVRMSDHLPTVEIRIS 240 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D P T+ + +A L+QA + D+ L + ++A R GL+G D Sbjct: 241 DVPATVEETMTLATLVQALVGTASAAITKGEAAPAVDHELLRAACWRAARDGLDGRSLDV 300 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 + + +L++ + P+ G + A +V S N A + R + + Sbjct: 301 ESVRLLTAHQAVRQLVDHVEPALTAFGEFEQVTASLDKVFSNGNGAIVQRRQLTRRSRVA 360 Query: 360 GLVKKHCEIW 369 ++ + Sbjct: 361 DVIDECARRT 370 >UniRef50_A0PNK6 Carboxylate-amine ligase MUL_1380 n=30 Tax=Actinomycetales RepID=CAAL_MYCUA Length = 392 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 97/368 (26%), Positives = 165/368 (44%), Gaps = 5/368 (1%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 DF S T+G+E E +V+ DLS +++ +I + V ++ + +E+ + Sbjct: 26 IDFARSPRPTVGVEWEFALVDAETRDLSNEATAVIAEIGE---NPRVHKELLRNTVEVVS 82 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 VC +A + +E+ GTHPF +W Q++ D RY ++ Sbjct: 83 GVCGSAGEAIEDLRTTLGPARRIVHARGMELFCEGTHPFAQWSTQKLTDAPRYAELIKRT 142 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 + +Q ++G HVHVG +S + + ++ L + PH +ALSA+SP+ G DT +AS+R Sbjct: 143 QWWGRQMLIWGVHVHVGVSSANKVMPIISALLNYYPHLLALSASSPWWGGEDTGYASNRA 202 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 +F P G W +FE T +ID I ++ WDIRPSPH GT+E+R+ D Sbjct: 203 MMFQQLPTAGLPFQFQTWSEFEGFVYDQKKTGIIDHINEIRWDIRPSPHLGTIELRICDG 262 Query: 244 PLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 L + L+ L + + N+++A RYGL+ VI Sbjct: 263 VSNLRELGALVALMHCLVVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDAE 322 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 + R +T+D +L ++ P A + + + A+ G + + R G L + Sbjct: 323 SNERLVTDDLDDVLTRLEPVARSLSCADELAAVAEIPRVGASYQRQRRVAEEHDGDLRAV 382 Query: 362 VKKHCEIW 369 V Sbjct: 383 VDALIAEL 390 >UniRef50_C8NYP5 Carboxylate-amine ligase n=1 Tax=Corynebacterium genitalium ATCC 33030 RepID=C8NYP5_9CORY Length = 395 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 94/372 (25%), Positives = 167/372 (44%), Gaps = 3/372 (0%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P DF+ SE +LG+E E+ V++P DL +I AV ++ ++ + ++ +EL Sbjct: 25 PFRDFNRSEGPSLGVEWEIGVIDPATRDLVARGPEVIQAVNDRWPDVHLEKEFLQNTVEL 84 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T VCR+ +A A + + + +L++ G HPF ++ Q V D YQ + Sbjct: 85 VTPVCRNTAEAIEYLRATKDKIQAVTDEKNLQLWASGGHPFSDFREQAVGDKPTYQEIVN 144 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y QQ ++G HVHVG + +++ + PH +A+SAASP +G DT +AS+ Sbjct: 145 RTQYWGQQMLLWGTHVHVGIRHEERVWPIINAIMTKYPHLLAVSAASPAWEGLDTGYASN 204 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R ++ P G NW ++ R + + + +H+D+RP+ +GT+EVR+ Sbjct: 205 RTMLYQQLPTAGMPYQFQNWSEWVQFMRDQTTSGVTSHTGSMHFDVRPAAKWGTIEVRIS 264 Query: 242 DTPLTLSHAVNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D TL + L + + + N+++ RYGLE + Sbjct: 265 DASPTLRELAAVVALTHCLVVHYDAMLDDGRDLPTLQPWHVAENKWRGARYGLEAEVITS 324 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 D R +T++ ++E++ P A ++G + + + G Q R G Sbjct: 325 RATDERLVTDELYDMVEELQPVAQRLGCVDELNLVPGIIEQGA-AYQRQRAIYERTGDWR 383 Query: 360 GLVKKHCEIWAG 371 +V G Sbjct: 384 DVVDATVAELRG 395 >UniRef50_C2CS07 Carboxylate-amine ligase n=14 Tax=Corynebacterineae RepID=C2CS07_CORST Length = 381 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 92/369 (24%), Positives = 173/369 (46%), Gaps = 3/369 (0%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 P F S TLG+E E+ +V+P +DL + LI+ V ++ + ++ +EL Sbjct: 4 PEESFARSAEPTLGVEWEVALVDPTTWDLVPRGAELIERVHAAAPEIHLEKEFLQNTVEL 63 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 T +C + +A + V AA + +++ G HPF ++ V E Y + Sbjct: 64 VTGICHTVPEAVADLAHKLSHVRAAADEMGVKLWASGGHPFTDFRENPVSAKESYSEIIN 123 Query: 122 NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 Y +Q ++G HVHVG D +++ L PH +A+SA SP +G DT +AS+ Sbjct: 124 RTQYWGKQMLLWGTHVHVGIRHEDRVWPIINALMTKYPHLLAISACSPAWEGLDTGYASN 183 Query: 182 RPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVM 241 R ++ P G +W+++++ R + + +I+ +H+DIRP+ +GTVEVR+ Sbjct: 184 RTMLYQQLPTAGMPYQFQSWEEWQSYMRDQAISGVINHTGSMHFDIRPASKWGTVEVRIS 243 Query: 242 DTPLTLSHAVNMAGLIQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 D L +A L + + +R + N+++ RYG++ ++ Sbjct: 244 DASSNLRELSAVAALTHCLVVHYDRMIDRGEELPILQPWHVAENKWRGARYGMDALVVTS 303 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 D R + ++ L+E++ P A ++G + + +H + G + R + GS Sbjct: 304 RETDERWIKDELADLVEELTPLARELGCAEELALIHEIIDDGA-GYERQRALYEETGSWQ 362 Query: 360 GLVKKHCEI 368 +V+ C+ Sbjct: 363 KVVEATCQE 371 >UniRef50_Q47E74 Carboxylate-amine ligase Daro_2114 n=1 Tax=Dechloromonas aromatica RCB RepID=CAAL_DECAR Length = 384 Score = 355 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 144/367 (39%), Positives = 221/367 (60%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF S F+LG+ELE+Q+V+ +DL++ ++ L+ ++ GE+K +ITESM+E++T Sbjct: 8 DFKDSAAFSLGVELELQLVSKRDFDLTRGATDLLGSLDYDERFGEIKLEITESMIEISTQ 67 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 ++ A S ++ + Q +++ ICGGGTHPF W + +C +R+ + +G Sbjct: 68 PQSTVDGIAADLSGLRDTLRQHCERNNIGICGGGTHPFHHWPERRICPGDRFNDLYQRYG 127 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 YL +Q TVFGQHVH+GC S D+AI+L +VP FIALSA+SP++ G D+ + S+R N Sbjct: 128 YLAKQFTVFGQHVHIGCTSADEAIWLTQAFGVYVPAFIALSASSPFVDGVDSFYQSARLN 187 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 SAFP +G P + +WQ+F F L + SIKDL+WD+RP P FGTVE+RV DTP Sbjct: 188 AVSAFPLSGQCPPLGSWQEFTEHFAFLQACGIAQSIKDLYWDVRPKPEFGTVEIRVCDTP 247 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 LT+ A ++A L Q+ A WLL RP H K + ++N+FQACRYG E +I+DP + Sbjct: 248 LTIEQATSLAALAQSLARWLLRTRPPLHTAKQAHVARYNKFQACRYGFEAMISDPVNLCQ 307 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 PL + LLE ++ A ++ + + L + V +A +R G+L +V++ Sbjct: 308 TPLKQTLADLLEAVSEDARELDCADWLSPLKQAVAENTGDAAWLRARENQHGNLNDVVRE 367 Query: 365 HCEIWAG 371 + G Sbjct: 368 ASKRLMG 374 >UniRef50_A3ZKZ3 Putative uncharacterized protein n=2 Tax=Planctomycetaceae RepID=A3ZKZ3_9PLAN Length = 378 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 107/374 (28%), Positives = 183/374 (48%), Gaps = 4/374 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F ++ FT+GIELE+ +V+ LS L+DA ++ A +K ++ + LE Sbjct: 1 MSKLVFTSNDAFTVGIELELGLVDSQTMALSSSVQRLLDAAPAEL-ASRIKPELMQCCLE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + T++C I +A V D L + G THPF W Q+V NERY + Sbjct: 60 INTEICTTIEEAESDLRRKLLAVQGLTDDLGLRLWWGSTHPFSHWCDQKVTQNERYLNLV 119 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 + + ++ G HVHVG SGD A+ + + +++P +ALS +SPY +G DT AS Sbjct: 120 DLLQEMARRLVTNGLHVHVGVESGDKAVMICDRIMQYLPLLLALSTSSPYWEGRDTGLAS 179 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R I P G P + NW ++ L + T I++I+++ WD+RP +FGTVEVRV Sbjct: 180 HRSKIMEGLPTAGLPPLMRNWSEYVWLVNHMVDTGFINTIREIWWDVRPHHNFGTVEVRV 239 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKD--YLLYKFNRFQACRYGLEGVITD 298 D P L A+ ++ +IQ L E + D ++ + N+++ACR+G + + + Sbjct: 240 CDMPGNLEDAMTISAMIQCLVKQLSDEIDHGAYQHDCHPMMVRQNKWRACRFGSDAKLVN 299 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 +T ++ RL+E++ A ++G + + + R + + G Sbjct: 300 SYTYQVESVSTVVARLVERLMAPAIELGCERYLLRAQD-IADRPTWSDRQRLILQETGDP 358 Query: 359 IGLVKKHCEIWAGD 372 +V++ E + Sbjct: 359 TEIVRRMSEQSRIE 372 >UniRef50_Q0RZ64 Carboxylate-amine ligase RHA1_ro08378 n=2 Tax=Nocardiaceae RepID=CAAL3_RHOSR Length = 385 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 90/360 (25%), Positives = 151/360 (41%), Gaps = 6/360 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+P S ++ +I + ++ +++ +E AT + I Sbjct: 16 PTLGVEEEFVLVDPHTGRPSLSNTDVI--ASGRELGITLQPELSRCQIETATSIGTHIRD 73 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 Q + V AA ++ GT P + D R++R E FG L Sbjct: 74 LRDQLCESRAVTADAAARTGCQLLAVGT-PMYSPPHDSITDTPRHRRIAEQFGALATGVM 132 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 G HVHVG + AI +++ L ++P +AL+A SP G DT +AS R +F +P Sbjct: 133 -CGCHVHVGVPGREQAIQIINHLRPWLPTLLALTANSPIADGCDTGYASWRYILFGHWPS 191 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P+ + ++A + + I + + WD+R + H TVEVR+ D P T+ + Sbjct: 192 AGPPPYFDSAAHYDAALAKMLESGAILDNRMVFWDVRAADHPPTVEVRISDVPATVEETM 251 Query: 252 NMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + L+ A ER D+ + ++A R GL G D T P Sbjct: 252 TLTTLVHALVITAADAIERGTPAPTVDHEALRGACWRAARDGLSGHGFDLTTMGLIPAPR 311 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIW 369 +LL + P ++G + V+ N A R +A G + ++ + Sbjct: 312 LIYQLLTHVKPVLVELGECGQVTGSLAAVLEHGNGAIRQRRTLARHGRVADVIAECARRT 371 >UniRef50_D2AQS1 Putative uncharacterized protein n=2 Tax=Actinomycetales RepID=D2AQS1_STRRD Length = 837 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 94/363 (25%), Positives = 172/363 (47%), Gaps = 5/363 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P +G+E E VV+ L + +L+D + A H++ S++E + + Sbjct: 7 PIAVGVEEEFHVVDVDTRHLVPRAGVLLDQL----PADRFTHELQRSVVEANSRPFIRLE 62 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A+++ V+QAA L I G+ P + ++ + RY++ L ++ L ++ Sbjct: 63 DLGHDLTALRRTVIQAADGLGLGIVAAGSVPLVDLEALKISPDPRYEQMLADYQLLTREQ 122 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 + G VH + D A+ + H L+ ++P +ALS++SPY G+DT +AS RP I+ +P Sbjct: 123 LICGTQVHAEVDNRDLAVAVAHRLAPWLPPLLALSSSSPYWLGSDTGYASYRPLIWQRWP 182 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP+ + +++ + L + +I +++DIRPS H TVE+R+ D +S Sbjct: 183 TAGPVAAFESAAEYDQVVGDLVRSGVITDPGMIYFDIRPSAHVPTVELRICDACPRVSDI 242 Query: 251 VNMAGLIQATA-HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 V +AGL +A L R + + + ++A R GLEG + DP G RP E Sbjct: 243 VLIAGLFRALVARELEAVRRGPDRSVRLEMVRAATWRAARSGLEGDLVDPVEGVPRPAAE 302 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIW 369 R+++ + P + G + +L +Q + + + R GG L +V Sbjct: 303 VIGRMVDGLRPQLEESGDRELVTSLAQQALGRGSSSARQRRAFVRGGRLADVVDLLVAET 362 Query: 370 AGD 372 + Sbjct: 363 RSE 365 >UniRef50_Q2J8X3 Carboxylate-amine ligase Francci3_2911 n=8 Tax=Actinomycetales RepID=CAAL2_FRASC Length = 861 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 152/359 (42%), Gaps = 6/359 (1%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E E +++ L + ++ + ++ +S++E + D+ + Sbjct: 9 VGVEEEFHILDLTTRQLVPRAEEVLRRL----DGDSFSPELLKSVVETNSQPTADLLELR 64 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 +++ + + + L GT P +V ++RY++ E++ + ++ + Sbjct: 65 TNLLDLRRRLAEVTGELGLGPAAAGTVPIVDMDLLDVSRDDRYEQMTEDYQIVAREQLIC 124 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 G VHV A D A+ ++ + ++P +ALSA+SP+ G D+ +AS R ++ +P G Sbjct: 125 GAQVHVDVADRDLAMAVVAWTAPWLPMLLALSASSPFWMGADSGYASMRTLVWQRWPTAG 184 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 +++ L L + +I +++D+RPS H TVE+R+ D + + + + Sbjct: 185 VAGSFRTAAEYDQLVADLIKSGVISDPGMVYFDVRPSAHLPTVELRICDACPDVDNVILI 244 Query: 254 AGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 AGL +A + E + L + ++A R GLEG + D P Sbjct: 245 AGLFRALVCQAIEEIEAGGQAPPPRAELLRAATWRAARSGLEGDLVDILGAGPIPAQAML 304 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWA 370 RLL ++ P + I+ L Q V + A R A G L + Sbjct: 305 RRLLTEVRPQLERFDDWELIDNLAEQAVGRGSSAHRQRRAFARRGLLTDVADLVLAETR 363 >UniRef50_Q7NTZ9 Carboxylate-amine ligase CV_2904 n=1 Tax=Chromobacterium violaceum RepID=CAAL_CHRVO Length = 377 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 141/365 (38%), Positives = 220/365 (60%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 +F+ S+P TLG+ELE+ ++N Y+L++ S L+ + K ++K +IT+ M+E+ T Sbjct: 3 EFNQSQPLTLGVELELMILNRRDYNLTRGSDDLLLQINRKPHGYDIKPEITQGMIEIGTA 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V D+N + A++ +++ +A +L + GGG HPFQ W+ Q + ERY+ E +G Sbjct: 63 VHSDVNAMLDELLAIRTLLVDSAHKLNLGLAGGGAHPFQHWEDQRIYPKERYKLVSELYG 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 YL +Q TV+GQH+H+GC GD A+ L H L+R++PHFIALSA+SP+ QG DT F +SR Sbjct: 123 YLAKQFTVYGQHIHIGCPDGDAAVRLTHYLARYIPHFIALSASSPFYQGVDTSFQTSRLT 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +AFP +G MP V +W F A F + ++ S+KD +WDIRP P +GTVE+R+ DTP Sbjct: 183 SVNAFPLSGCMPVVDSWDAFNAYFERMEALGIVASMKDFYWDIRPKPEYGTVEIRICDTP 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 L++ V +A Q A E + YL Y +NRFQACR+G +GV+ D + + Sbjct: 243 LSVETPVLLAAYAQMLARRCFEESWNDICPEPYLTYSYNRFQACRFGFDGVMVDARSKSQ 302 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 L ED L L + P A +G+ + AL ++ + ++++ +R GSL +V++ Sbjct: 303 LGLQEDLLDTLRALEPHAEALGSQHQLAALRQRALKCHSDSRWLRQIFEQSGSLSEVVRR 362 Query: 365 HCEIW 369 E W Sbjct: 363 QSEHW 367 >UniRef50_Q82PC4 Carboxylate-amine ligase SAV_999 n=4 Tax=Streptomyces RepID=CAAL2_STRAW Length = 366 Score = 350 bits (898), Expect = 5e-95, Method: Composition-based stats. Identities = 91/363 (25%), Positives = 165/363 (45%), Gaps = 6/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKI--TAGEVKHDITESMLELATDVCRDI 69 +T+G+E E +++P + + A + E++ +++E+ +E+AT VC + Sbjct: 4 YTVGVEEEYLLLDPATRLPMPAAEQVRAAAGLEPIAGEDEIQPELSEAQVEVATPVCTSL 63 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 ++ G ++ V+ +AA + + GT P ++ + +N RY+ L+ + Sbjct: 64 DEIGGHLVRLRHVLGRAAESNGCRLAACGTPPIKEESPPPLTNNPRYRAMRAQAPQLVAE 123 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG + + +L+ + ++P +A+SA SP+ G DT FAS R IF + Sbjct: 124 QLVCGTHVHVGVPDPEIGVAVLNRIRLWLPVLVAMSANSPFWAGHDTGFASWRTVIFGRW 183 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P +GP P ++ E + L +I L+W R S + TVEVR +D L Sbjct: 184 PVSGPPPHFADLADHEKRVQQLLTCGVIFDPGQLYWQARLSSRYPTVEVRCLDVQLRADD 243 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV AG+++A + + L + + A R+GL G + D + G RR Sbjct: 244 AVMFAGIVRALVATAINDAKAGVPVPSCPPELLQGANWHAARHGLSGSLID-YEGRRRSA 302 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 + +L++ I P+ S + +L +++ A R + GG L + Sbjct: 303 GDVLSQLMDHIGPALDAADDSREVASLVHRLLREGTPADRQRRALLRGG-LRAVTDLIIT 361 Query: 368 IWA 370 A Sbjct: 362 ESA 364 >UniRef50_A1VTI2 Carboxylate-amine ligase Pnap_3664 n=93 Tax=cellular organisms RepID=CAAL_POLNA Length = 381 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 149/371 (40%), Positives = 230/371 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S +LG+ELEMQ+VN YDL+ + ++ + G V ++T SM+E Sbjct: 1 MSLEPFQKSSALSLGVELEMQLVNTHDYDLAPYAEDMLRLMSKIALPGAVVPEMTSSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 ++T +C + GQ + ++ ++++A ++ + GGGTHPFQ+W + + D R++ Sbjct: 61 VSTGICHSSAEVLGQLTQIRDALVKSADKLNIAVVGGGTHPFQQWHERRIYDKPRFRELS 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +GYL +Q T+FGQHVH+GC D A+ LH +SR++PHFIALSA+SPY+QG DT F S Sbjct: 121 ELYGYLSKQFTIFGQHVHIGCPDADTALLTLHRMSRYIPHFIALSASSPYVQGQDTAFDS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 +R N AFP +G P+ W +F F +++T ++ S+KD +WDIRP P FGT+E+RV Sbjct: 181 ARLNSVFAFPLSGRAPFALTWDEFTVYFNKMAHTGVVKSMKDFYWDIRPKPEFGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLT+ A +AG +Q+ W + ++PF E DYL+Y +NRFQACR+GL+ V DP Sbjct: 241 FDTPLTIERATALAGYVQSLGSWFMNDQPFMPTEDDYLVYTYNRFQACRFGLDAVYVDPA 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 TG PL E L + +I AH++ AS++I L V N+A+ +R+ + L Sbjct: 301 TGGHMPLREHILMTMAQIERHAHRLDASASIHLLRTSVERNDNDARWLRERQGEERLLAE 360 Query: 361 LVKKHCEIWAG 371 ++++ + + G Sbjct: 361 VIRQAADRFRG 371 >UniRef50_C5BZX5 Glutamate--cysteine ligase GCS2 n=7 Tax=Actinomycetales RepID=C5BZX5_BEUC1 Length = 388 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 91/371 (24%), Positives = 171/371 (46%), Gaps = 4/371 (1%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE--VKHDITESMLELA 62 +F SE ++GIE E+ +V+ DL Q + ++DAV+ +K ++ + +E+ Sbjct: 8 EFAHSERSSVGIEWELALVDADSGDLRQVAQTVLDAVRPDGAEEHPLIKQELLLNTVEVV 67 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + V R + A + + +E+ G+HPF +W +Q+V + ERY ++ Sbjct: 68 SGVQRTVADAGRDLERAIDAIREVTDPLRVELMCAGSHPFARWTQQKVTNKERYATLIDR 127 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 + +Q ++G H HVG + + + PH +LSA+SP+ G DT +AS+R Sbjct: 128 TQWWGRQMLIYGVHTHVGIEDRSKVLPIARAMLTVAPHLQSLSASSPFWGGKDTGYASNR 187 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 +F P G + W + E + +T +ID + ++ WDIRPSP GT+EVRV D Sbjct: 188 ALMFQQLPTAGLPFAFTEWAELEQYVGDMLHTGVIDDVTEIRWDIRPSPRLGTLEVRVCD 247 Query: 243 TPLTLSHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 TL + ++ + + + + N++++ RYG++ ++ Sbjct: 248 GTPTLGELLALSAFTHCLVEHFSSMLDAGEQLPAMPPWFVQENKWRSARYGMDAILILDA 307 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 GD R +T+ L+ + P A ++G S+ ++ + + G + + GG L Sbjct: 308 DGDERLVTDSVHDWLQVLEPVAERLGCSAELDDVRAILRDGASYQRQRAAAERAGGELDA 367 Query: 361 LVKKHCEIWAG 371 +V Sbjct: 368 VVDLLVREMRA 378 >UniRef50_Q7USI0 Carboxylate-amine ligase RB4485 n=1 Tax=Rhodopirellula baltica RepID=CAAL_RHOBA Length = 372 Score = 347 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 85/364 (23%), Positives = 160/364 (43%), Gaps = 10/364 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKN----KITAGEVKHDITESMLELATDVCR 67 T+G+E E Q+V+P L + ++ ++ + E++H++ + +E+A+DVC Sbjct: 6 PTVGVEEEYQLVDPRSGALIPNCKEVMRTIRRNGGSEEAHSEIQHELHLNQIEMASDVCS 65 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + + + +++++ AA + E+ GT+P + +RYQ + + + Sbjct: 66 SLEEVRDALTQTRRMLIDAARSNETELASAGTNPLPIPTDDALTPKDRYQAMTDRYQQIA 125 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + +FG HVHV + I +++ R++P A++A SPY G DT +AS R +++ Sbjct: 126 RDLFIFGCHVHVAMEDRELGIQVMNRCRRWLPILQAITANSPYWDGVDTGYASYRRELWA 185 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP + +++ L I L+WDIR T+E R D + Sbjct: 186 QWPMAGPPAHFDSLADYQSCVDDLVACGAIKDESFLYWDIRLPTRVPTIEFRAADVMTRV 245 Query: 248 SHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 V G+I+A + E+ + + + A RYG+ + DP + + Sbjct: 246 EETVGYVGMIRAIVMLAISEEEQGKPIVPIRPSVLSYAIWHAARYGMNEQLVDPESREMI 305 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P +E RL+ I P+ G + +EA Q++ A R GG L +V Sbjct: 306 PASELLNRLMTAIDPALKATGEARPVEAFANQLIKSGTGADRQR----RGGELSSVVANV 361 Query: 366 CEIW 369 Sbjct: 362 VAET 365 >UniRef50_D2AQR8 Carboxylate-amine ligase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2AQR8_STRRD Length = 370 Score = 343 bits (880), Expect = 7e-93, Method: Composition-based stats. Identities = 95/366 (25%), Positives = 158/366 (43%), Gaps = 5/366 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + T+G+E E + + + +++ G V+ ++ + +E + VCR Sbjct: 2 RASELTVGVEEEFFLADVATRHAVLRAETVLEGTAPVPGGGRVEPELARAQVESVSAVCR 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 DI + +++ V AA + + G P V D RY R E FG L+ Sbjct: 62 DIGSLREELLRLRRSVAAAAESNGCRLVASGVVPLGDPGPPPVSDRPRYHRIAERFGPLL 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 Q + HVHVG ++A+ +++ L ++P + LS+ SP+ +G DT +AS R +F+ Sbjct: 122 DQQSACACHVHVGVPDPEEAVQVVNHLRMWLPVLLVLSSNSPFWRGRDTGYASWRTPLFA 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P++S ++E + CL T I L W RPS H TVEVR+ D T+ Sbjct: 182 RWPTAGPPPYLSGRAEYEEIVECLRETGAILDGGMLFWYARPSRHVPTVEVRIADVMPTV 241 Query: 248 SHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDP---HTG 302 V A L++A +LT+ R L + ++A RYGL G D Sbjct: 242 DDTVLFAALVRALVATVLTDLRRGRAAPAAGDHLLRAACWRAARYGLRGDGVDVSGRVDE 301 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 P + +L+E ++P+ G A+ A R + A R +V Sbjct: 302 RLIPASGQIKQLMEYVSPALEASGEDGAVRAGLRALRLRGTGADRQRAAYRRRNRFEDVV 361 Query: 363 KKHCEI 368 + Sbjct: 362 DLLADQ 367 >UniRef50_B8HF13 Glutamate--cysteine ligase GCS2 n=13 Tax=Actinomycetales RepID=B8HF13_ARTCA Length = 409 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 87/366 (23%), Positives = 150/366 (40%), Gaps = 7/366 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLID---AVKNKITAGEVKHDITESMLELATDVCR 67 P T G+E E+ +V+P D + L+D + + + M+E+ T Sbjct: 33 PRTFGVEEELLLVDPGRGDAVPMAGALLDLYVRPLESSAGPVLTAEFQQEMIEVVTPPHS 92 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A + + QAA D + + GT P R+ +E +G Sbjct: 93 TLAGLQADIVAGRDIARQAAEDVGVRVAALGTSPL--PSDPHPVRLRRFAAMVEEYGLTA 150 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ G HVHV S ++A+ +L + ++P +ALSA SP+ G DT +AS R ++S Sbjct: 151 REQLTCGTHVHVSVESDEEAVGVLDRIRNWLPVLVALSANSPFWHGEDTGYASYRSQVWS 210 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP+ + + L + T + +++D R S H+ TVEVR+ D + Sbjct: 211 RWPSAGPLDILGTPDAYHQLVHDMVSTGVAMDEGMIYFDARLSRHYPTVEVRIADACMMP 270 Query: 248 SHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + V +AG+++ E L + ++A R+GL G + DP T Sbjct: 271 ENTVLLAGIVRGLVETAAREWKAGTGPAPVPTALLRLAGWKASRWGLRGELLDPVTSRPG 330 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P LL I + +G +E L Q++ A + + G L +V Sbjct: 331 PALGVVNSLLHHIHGALEDMGDLERVEELTDQLLHTGTGAVRQLEVLHRTGDLEDVVDDA 390 Query: 366 CEIWAG 371 G Sbjct: 391 ANCTVG 396 >UniRef50_Q3M5M3 Carboxylate-amine ligase Ava_4113 n=2 Tax=Nostocaceae RepID=CAAL_ANAVT Length = 387 Score = 342 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 106/377 (28%), Positives = 173/377 (45%), Gaps = 10/377 (2%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M +F S F+LG+E+E+Q++NP L S L+ ++ + ++M+E Sbjct: 1 MGDIEFKSSPEFSLGMEIELQLLNPDTLQLVDGISPLLAQTPE---NSWIQPEFNQAMVE 57 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +A+ VC +I + A+ + + + IC GT+P + + RY Sbjct: 58 IASQVCSNIPELEANIVAILRDLKTRCQALGMTICTAGTYPCCD-RFASITPIPRYLSQQ 116 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 GYL +HVG SGD AI ++ L ++P +ALSA+SP+ G DT FAS Sbjct: 117 NTSGYLADLMMTCALQLHVGMPSGDVAIDIMGRLKPYLPILLALSASSPFWWGHDTSFAS 176 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R S+ G P NWQ F F M + I+D+HWD+RP P FGT+EVRV Sbjct: 177 FRQRFLSSMRTYGICPTFKNWQDFTNFFATAQNAGMFEIIRDIHWDLRPQPDFGTLEVRV 236 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLT-----ERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 MD T+ ++ +A I + + + F +L+ + N F+A R+GL+ Sbjct: 237 MDAQPTIKESMMLAAFIHSLIVDMYHHSQGKQTEFLLTPLPWLIERENYFRASRWGLDAN 296 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + G+ RP+ +L +A +A +G SS + L +++ G + R Sbjct: 297 YIEDEQGNSRPIRNIVKDILNVLAETADTLGNSSYLFQLEKRLDQGASY-IRQRRVFEST 355 Query: 356 GSLIGLVKKHCEIWAGD 372 GS+ +V + Sbjct: 356 GSVKAVVASLVSELEAE 372 >UniRef50_Q0S8V5 Carboxylate-amine ligase RHA1_ro04240 n=31 Tax=Bacteria RepID=CAAL4_RHOSR Length = 793 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 85/366 (23%), Positives = 163/366 (44%), Gaps = 7/366 (1%) Query: 9 SEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRD 68 S+P +G+E E +++ L+ + L+ + + + ++ + ++E+ + V D Sbjct: 4 SDPRKVGVEEEFHLIDLKTRRLTTRAPELLARLPDDVYVD----ELQQCVVEVNSGVYAD 59 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ 128 ++ +++++ AA D + + G+ P V +RY R L ++ L + Sbjct: 60 LDGLRSDLERHRRLLVDAAEDLGIGVAAAGSVPLALPAEMHVTGTQRYGRMLADYQVLAR 119 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM-QGTDTRFASSRPNIFS 187 + + G VHV D+A+ + H ++ +P +ALSA+SP+ G DT +AS+R ++ Sbjct: 120 EQLICGTQVHVDLPDRDEAVQVAHRVAPHMPVLLALSASSPFRSDGADTGYASARTLLWL 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP VS+ ++ AL L + +I ++D+RPS T+E+RV D+ L Sbjct: 180 RWPSTGPAAPVSSAAEYGALIDDLVASGVISDPGMAYFDVRPSVKLPTLELRVCDSCPRL 239 Query: 248 SHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + +A L +A + K E L + ++A R GLE + D R Sbjct: 240 DTVLLVAALFRALVEREVEGLRAGRKGVEVLPTLTRAALWRAARSGLEEELVDVTVPQAR 299 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P +E + + P + G + L + + + A R + G L +V Sbjct: 300 PASELVGDFVNSLRPQLEETGDWDRVVELSAEATAHGSSAARQRQALGRRGRLTDVVDLL 359 Query: 366 CEIWAG 371 AG Sbjct: 360 LAETAG 365 >UniRef50_C4RQD7 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromonospora RepID=C4RQD7_9ACTO Length = 382 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 86/367 (23%), Positives = 163/367 (44%), Gaps = 4/367 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++ FT+G+E E +V+P ++++ V ++ G+V+ + S +E+ + Sbjct: 18 GGTDLFTVGVEEEFLLVDPHTGTAVPAVDLVMEQVPAEL-RGQVEREFQTSQIEIGSPPG 76 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 +++ +++ + AA + + GT V D R+ R +E F L Sbjct: 77 LELSSIRHSLGVLRRALADAAERAGVRVLAIGTG-PVDGPVPPVVDKPRFDRMIERFRLL 135 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + G HVHVG + + +L+ + ++P A++ SP+ G DT +AS R + Sbjct: 136 VPGPGNNGMHVHVGVPDPETGVRVLNHVRPWLPILHAVTTNSPFFAGEDTGYASWRSVEW 195 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 +P P P++ + + +E L R L + ++ L+W R S + TVE+R+ D + Sbjct: 196 ERWPSVAPTPYLESHEHYERLIRQLIASGVMLDEGMLYWYARLSAKYPTVEIRIGDVCPS 255 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEK--DYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + AV +A L++A +T+ D+ L ++A GLEG D G+ Sbjct: 256 VDDAVLVAALVRALVATAMTDIAEGRPPIRTDHHLLVAAHWRAAHDGLEGQCVDLTDGEL 315 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 RP E L+E++ P+ + G + + L + A R A GSL+ +V+ Sbjct: 316 RPGWERLDSLVERLGPALERHGDLAEVTDLLGGLRRHGTGAARQRAVFARTGSLVDVVRD 375 Query: 365 HCEIWAG 371 Sbjct: 376 VARQTRA 382 >UniRef50_C3JVV2 Carboxylate-amine ligase n=2 Tax=Rhodococcus erythropolis RepID=C3JVV2_RHOER Length = 392 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 93/365 (25%), Positives = 165/365 (45%), Gaps = 6/365 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 H S T+G+E E +V+P + S D++ + + +++ +++ +E + VC Sbjct: 14 HESTTPTVGVEEEFILVDPTSWLPSTDNAAVAETAS--TLGLDLQLELSRCQVETNSPVC 71 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 I++ + M+++ +AA + + G P R E+ D+ RY+R E FG L Sbjct: 72 HGIDELRTHLTDMRRLAAKAAELNGCRLLAVGA-PLSGPSRFEISDSPRYRRMGERFGAL 130 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + ++ G H+HVG A A+ + + + ++P +ALSA S QG DT FAS R + Sbjct: 131 AAEQSICGCHIHVGVADQVQAVQVCNHVRIWLPALLALSANSRVHQGVDTDFASWRAIQW 190 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P+ F+ + ++ + +WDIRPS H TVE+RV D T Sbjct: 191 SRWPVAGPPPYFETTGDFDTAVAKMVDCGVMLDKRMAYWDIRPSCHLPTVEIRVCDVQPT 250 Query: 247 LSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 A +A L +A L +R + + + + + G+ G DP T R Sbjct: 251 AEDAALLATLGRALVATALRAIDRGIEAPNISLESLRLATWVSAKEGVLGASIDPITSQR 310 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 TE RLL + S + G +++E+ + N + + + L L+ + Sbjct: 311 ISATELLHRLLIHVRDSLDEGGEYASVESALQHKSVTGNGSDWQQRTLRQV-CLRELIAR 369 Query: 365 HCEIW 369 + Sbjct: 370 AVQRT 374 >UniRef50_Q5ZS01 Carboxylate-amine ligase lpg2719 n=5 Tax=Legionella RepID=CAAL_LEGPH Length = 383 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 145/372 (38%), Positives = 230/372 (61%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F S+ ++G ELE Q+++ L S L+ A+K+ ++K +IT+SM+E Sbjct: 1 MRLLSFKKSKIVSIGTELEFQIIDCSSLSLVSRSKELMRALKDMRYRDQIKPEITQSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + + + + + + +QK++++ A + CGGGTHPFQ+W Q++ ++R+++ Sbjct: 61 INSSIHQSAKEMYDELLELQKILVETAASIDIAFCGGGTHPFQQWTMQKIFPSKRFKKKF 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 + YL ++ATVFGQH+H+GC +GDDAIYL H L+R+VPHFIA+SA+SP+ G +T + S Sbjct: 121 NQYRYLSKRATVFGQHIHIGCPTGDDAIYLTHALARYVPHFIAISASSPFYLGINTNYCS 180 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR IF+AFP +G +P++ NWQ+F +R + +I+++KD +WDIRP P GT+E+RV Sbjct: 181 SRSTIFNAFPLSGVIPYLRNWQEFSDYYRKMYRWKIIENMKDFYWDIRPKPELGTIEIRV 240 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPLTL ++ + IQA A +LL E+ + Y +Y +NRFQA R+GLEG +T Sbjct: 241 CDTPLTLRKSILITAYIQALALYLLEEKSVQLSHDLYYVYNYNRFQASRHGLEGELTVTD 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P+ +D L ++KI + +G S IE L+ V++ N++ L+ GS Sbjct: 301 KDRPIPIMDDILETIKKIEQYINGLGNSEYIEELYSDVINKQNDSVLINKIYKQDGSFSK 360 Query: 361 LVKKHCEIWAGD 372 LV CE+W D Sbjct: 361 LVAAQCELWLSD 372 >UniRef50_C6W8C0 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6W8C0_ACTMD Length = 373 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 93/369 (25%), Positives = 165/369 (44%), Gaps = 4/369 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 +P+P T+G+E E +V+ +L ++ ++ +++ ++T+ +E Sbjct: 9 LPIPRSGSGTALTIGVEEEFLLVDEVTGELVPLGPQVLSGPPDR--GLDLQPEMTQYQVE 66 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 AT VCR ++ Q A + + + A H + G + D+ RY+R + Sbjct: 67 SATAVCRTASEVREQLLAARAALARRAAAHGARLVASGAPVLGGEHPPPLTDHPRYRRIM 126 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +G L+ T+ G HVHVG S + + + + L R++P +ALSA SP+ +G DT +AS Sbjct: 127 ERYGALVDGLTICGCHVHVGIPSPSEGLVISNHLRRWLPVLLALSANSPFHEGRDTGYAS 186 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R +++ +P GP PW + + + L + ++WD+R S + TVE+RV Sbjct: 187 WRHVVWNPWPSAGPPPWFDSVEDYRLATHLLRTSGAALDDGMVYWDVRLSANHPTVELRV 246 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D T+ AV +A L++A A L+ L + +QA R+G EG DP Sbjct: 247 CDVAATVEEAVVLAALVRAIAATALS--GEAAPRVSDRLLRVALWQAARHGPEGAAVDPL 304 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 +G P E+ LL + G + + +++ A R G Sbjct: 305 SGVPVPFAEEVGGLLRWCGAALDAAGDTELVVEGVARLLRDGGGAARQRKAYRRRGEFTD 364 Query: 361 LVKKHCEIW 369 +V+ Sbjct: 365 VVELLTTRT 373 >UniRef50_UPI0001C317D2 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C317D2 Length = 366 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 107/365 (29%), Positives = 183/365 (50%), Gaps = 7/365 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +T+GIE E+ +++ +L+ I+ + T+ +VK ++ ES+LE+AT Sbjct: 6 DGPNYTIGIEEELMILDAESLELANA----IEGMLEDSTSDQVKPELMESVLEIATSPQP 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D A + +++ V + A L I GTHPF W+ Q + RY+ + + ++ Sbjct: 62 DAAAAGEELRDLRRQVRETAASRGLAIGSAGTHPFAMWEEQRIVGRTRYRDLVSDLKFVA 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +Q +FGQHVHVG D AI++ +G+ +P +ALSA SP+ + T AS+R IF Sbjct: 122 RQEIIFGQHVHVGLDDADKAIHVANGMRIHLPVLLALSANSPFWRADATGLASTRTPIFR 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 AFP G P +W + A + + +I+ L +D+RP P+ GTVE+RVMD+ + Sbjct: 182 AFPRVGIPPTYDDWDDYAAKIGFMVESRVIEDYTYLWYDVRPHPNLGTVEIRVMDSQTRV 241 Query: 248 SHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 H + A LIQA L E + + + + N++ A R+GL+G + D + +R Sbjct: 242 EHTLAFAALIQAMVKELAEHFEAGKRLSKYPHQMIDENKWLAARHGLDGELVDLPSTERV 301 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 E RLL+++ A +G+++ +E + ++ N A R L +V + Sbjct: 302 RTRELAHRLLDRLRDHAQDLGSAAELEGIED-LLERGNGAARQRVVYEANHDLREVVAEI 360 Query: 366 CEIWA 370 A Sbjct: 361 VAATA 365 >UniRef50_UPI0001B55095 hypothetical protein StAA4_23572 n=1 Tax=Streptomyces sp. AA4 RepID=UPI0001B55095 Length = 364 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 2/360 (0%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 + T GIE E VV+ G L+Q ++ A + GE++H++ +S E+ATDVC Sbjct: 4 QTGDELTFGIEEEFFVVDRDGR-LAQADDVVDRAAETGGENGELQHELIQSQAEIATDVC 62 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 R ++A + +++ + AA + + P EV +N RY+R E+FG Sbjct: 63 RTRDEALRRLRELREDLASAARKRGRRLLPAASPPVSAEDLPEVTENPRYERIGEHFGAT 122 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + + G HVHV + I +L + ++P + ++A S G DT + S R + Sbjct: 123 ARTSLTCGCHVHVAIPDKETGIQVLGRIRPWLPVLLTVTANSAIADGYDTGYRSWRYQQW 182 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 S +P GP P ++ ++E++ + I ++WD+R S T+E R+ D T Sbjct: 183 SRWPSAGPPPRFASLDEYESIVDAWLRSGAILDRGMVYWDVRLSEKQPTIEFRIADVAAT 242 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 AV + L + L + + + + ++A R G+ G P +GD P Sbjct: 243 PEEAVLLGVLARGLVATALADDG-PPPDLPNEVLRAQLWRASRDGVSGCCPHPRSGDLAP 301 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHC 366 E L+E + G Q+ + + A R A+ G +V Sbjct: 302 TKEVLADLIELTTGALESAGDLEFAREATAQLCAEGSGADRQRRRFAERGRGEDVVDLLA 361 >UniRef50_A4FDR2 Carboxylate-amine ligase SACE_2909 n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=CAAL1_SACEN Length = 374 Score = 334 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 93/362 (25%), Positives = 166/362 (45%), Gaps = 4/362 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 TLG+E E +++P + + + + + GEV ++ + +E AT VCR + Sbjct: 3 DLTLGVEEEFLLLDPGTLEPAAAADR----FRAETDRGEVHRELAPAQIESATAVCRTLE 58 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + S +++ + A + + G P V D+ RY+R E +G +I+ Sbjct: 59 ELHHDLSGLRRALAADAAEQGYRLASVGVPPIGSAGPPPVTDSPRYRRMYETYGSIIEDQ 118 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHVG + A+ + L ++P + L+ SP+ +G DT +AS R ++S +P Sbjct: 119 GVCGCHVHVGALDLETALVAGNHLRPWLPALLLLTTNSPFFRGGDTGYASWRTTLWSRWP 178 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP P +++ + + + CL + + L+W RPS T+EVRV D T+ A Sbjct: 179 AAGPPPVLTSARHYHYVVDCLLASGAVLDSGMLYWYARPSHRVPTLEVRVADAAATVDEA 238 Query: 251 VNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 V +AGL++ L++RP + D + + + + +GLEG D TG P Sbjct: 239 VLLAGLVRGLVGVALSDRPGPVRPVDDAVLRAACWCSAHHGLEGFSLDVGTGRLVPSWHL 298 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWA 370 L+E + P + G A+ AL ++ + A+ R+ + +V+ Sbjct: 299 VDDLVEHVRPVLERYGDLDAVRALLAKLRENGSAARRQREVFRRHRDIGEVVEHVLVETV 358 Query: 371 GD 372 D Sbjct: 359 PD 360 >UniRef50_C0INB1 Putative uncharacterized protein n=2 Tax=environmental samples RepID=C0INB1_9BACT Length = 384 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 81/362 (22%), Positives = 140/362 (38%), Gaps = 11/362 (3%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P+ +GIE E V + ++ + S K V ++ +S +E+ T C + Sbjct: 12 PYRIGIEEEYFVSDLRTGNVRRIMSKAFYNACEKELGEAVTPELLQSQIEVRTPPCGTMQ 71 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A S ++V+ + A H L I GTHP W Q+ + ERY E+ L + Sbjct: 72 EARDHLSHYRRVLAREAVRHSLAIVASGTHPLAIWHEQQQTEKERYGEVREDLQMLAMRN 131 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV + + +++ L F+P +ALS +SP+ QG T R + P Sbjct: 132 MVCGMHVHVEVPDPESRVGIMYRLMPFLPPLLALSTSSPFWQGYRTGLLGYRLTAYDELP 191 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G N +++ L+ +I L W +RPS T+E+RV D + Sbjct: 192 RTGLPELFRNAEEYRRYVDTLTEAGVIKDASFLWWAVRPSLAHPTLELRVADCCTHVEDT 251 Query: 251 VNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A + + L+ E + N+++A RYG D RP+ Sbjct: 252 LAIAAIYRGLMRHLVEHAELNADLDVVGRAVAMENKWRAQRYGTAATFIDARARTARPIA 311 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA--------DGGSLIG 360 + +LE I + + ++ + A +L Sbjct: 312 DVLRYILELIRADTDALDCTKEAAHAFE-ILKRGSSADQQIRVYRTARDAGASRPKALKD 370 Query: 361 LV 362 +V Sbjct: 371 VV 372 >UniRef50_A8M5J6 Carboxylate-amine ligase Sare_2729 n=2 Tax=Salinispora RepID=CAAL_SALAI Length = 378 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 82/376 (21%), Positives = 148/376 (39%), Gaps = 8/376 (2%) Query: 1 MPLPDFHVSEPF---TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITES 57 M TLG+E E +++ + ++ ++D + + + + + S Sbjct: 1 MTYRPATDGPDLASLTLGVEEEFLLLDAETGESMPVAARVLDGLSG-VAHAQSRREFRHS 59 Query: 58 MLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQ 117 M+E+ T V D+ + A++ AA + G P + V D RY Sbjct: 60 MVEMVTPVLSDLAELRRHLVALRTAAADAAEAAGARLVAVGATPV-NETHRTVPDEPRYH 118 Query: 118 RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 FG + V G HVHVG + A+ + + L ++P A++A SP G DT Sbjct: 119 AMSRRFGPVAHDPAVCGCHVHVGLPDRELAVQVCNHLRPWLPVVQAITANSPLHDGQDTG 178 Query: 178 FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVE 237 AS R +P GP P+ + ++A L ++ ++W +RPS + TVE Sbjct: 179 HASWRAMQLERWPSIGPTPYFDSAADYDATVADLIKAGIMLDAGMVYWYVRPSAAYPTVE 238 Query: 238 VRVMDTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +RV D T+ V +AGL++A + + + L ++A GL+G Sbjct: 239 IRVGDVCPTVDDTVLVAGLVRALVATVAADVHDGARAPRIRGCLLSAAHWRAAHDGLDGD 298 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + D TG RP + L + P+ + G + + +V + A R + Sbjct: 299 LVDLRTGRARPAWDLVDDLFALVTPALERQGDRAYVRDQLARVRAEGTGAVRQRRILDRS 358 Query: 356 G-SLIGLVKKHCEIWA 370 + ++ Sbjct: 359 ACDVRAVLDHLAAQTR 374 >UniRef50_Q0SH75 Carboxylate-amine ligase RHA1_ro01287 n=2 Tax=Rhodococcus RepID=CAAL1_RHOSR Length = 369 Score = 331 bits (848), Expect = 4e-89, Method: Composition-based stats. Identities = 82/370 (22%), Positives = 154/370 (41%), Gaps = 6/370 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M ++G+E E +V+ LS ++ + I ++ ++ +E Sbjct: 1 MSPAATESGRDLSVGVEEEFFLVD-ESGHLSAAGPDVVTEAGHDIHG--LQRELARCQIE 57 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 AT VC + + ++++ + +AA L + GT + + + RY+ Sbjct: 58 TATGVCHTGEELHEELRSLRRRLAKAAAGRDLLLLPSGTSLVVEGLPPAITPSPRYEEMA 117 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 +FG ++ T G HVHVG S D + + + + ++P +AL+A SP+ G DT + S Sbjct: 118 RHFGSIVDTVTTCGCHVHVGIPSRDVGVRVSNLVRSWLPVLLALAANSPFHSGHDTAYHS 177 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R ++S +P GP P + ++EA + T ++W +R + T+EVR+ Sbjct: 178 WRHIMWSRWPSAGPPPHFDSADEYEATVGAMIGTGAAMDRGMIYWHVRLADKQPTIEVRI 237 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 D +T +HA A +++ W L + L + ++A R GL+G T Sbjct: 238 ADVAMTAAHAALYAVVVKGLVGWALQSLDDGLTVPWLRAELLRAQLWRAARDGLDGECTS 297 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 P P+ L + +AP + +E+ V+ A+ R G+L Sbjct: 298 PAADRVLPIRRQLELLNDCVAPGLGPS-DRAFLESGLDTVLREGTGAERQRAEFTRVGTL 356 Query: 359 IGLVKKHCEI 368 +V Sbjct: 357 AAVVDLLTRE 366 >UniRef50_Q1AWB5 Carboxylate-amine ligase Rxyl_1350 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL2_RUBXD Length = 363 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 165/365 (45%), Gaps = 6/365 (1%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F S P+T+G+E E Q+++P L+ ++ A ++ G + +++ S LE+ T Sbjct: 5 FGASPPYTVGVEEEFQLIDPRTRALTPKIEEVLAAGDGELPEGTLASELSASCLEVRTPA 64 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + + A A++ V + A + G HPF Q + RY++ E G+ Sbjct: 65 YASVAELARALPALRARVRRLAERSGARLVSAGAHPFSPAAEQPITGKPRYRKVDEEMGW 124 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++G HVHV G++A+ + L+R VP FIALSA SP+ +G DTR AS R + Sbjct: 125 PARMQAIYGLHVHVAVPGGEEAVRAVSALARHVPLFIALSANSPFWEGRDTRLASVRAKV 184 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 F P +G P ++W++F L I WD+RP P GTVE+R D Sbjct: 185 FGLIPRSGLPPRFASWEEFVRHVERLVRAGSIRDYTFCWWDVRPHPKLGTVELRAPDAQT 244 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +A L + + +D LL + N+++A R+GLE + D Sbjct: 245 DPGRTAALAA-----LCQCLAAAAEEFEPEDPLLTEENKWRATRHGLEAELYDFSGQRTV 299 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 L+ ++ P A ++G + +E + + A R +A GSL +V Sbjct: 300 AARRAAEELVGRLLPVARELGCEAELEGVLE-ISRSATGADRQRAVLAREGSLKSVVDYL 358 Query: 366 CEIWA 370 E A Sbjct: 359 AEATA 363 >UniRef50_D1VQ82 Putative uncharacterized protein n=1 Tax=Frankia sp. EuI1c RepID=D1VQ82_9ACTO Length = 901 Score = 329 bits (845), Expect = 8e-89, Method: Composition-based stats. Identities = 84/340 (24%), Positives = 148/340 (43%), Gaps = 8/340 (2%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 + +G+E E +++ L + +++A+ AG ++ +S++E + R Sbjct: 6 DTPIPAVGVEEEFHILDLVTRALVPRAGEILEAL----PAGRFTSELLKSVVETNSAPTR 61 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D+ ++ + AA L GT P R EV + RY + E + L Sbjct: 62 DLAALRADLVDLRHELAAAAEPLGLGPVAAGTVPIVDPDRLEVSRDPRYLQMTEEYQILA 121 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 ++ + G HVHV D A+ ++ + ++P F+ALSA+SP+ G D+ +AS R ++ Sbjct: 122 REQVICGAHVHVDVGDRDTAMAVIARVGPWLPLFLALSASSPFWLGADSGYASMRTMVWQ 181 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P G +++ L L + +I +++DIRPS H TVE+RV D + Sbjct: 182 RWPTAGVTGRFQTAAEYDQLVADLVKSGVISDPGMVYFDIRPSAHLPTVELRVCDACPDV 241 Query: 248 SHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG--D 303 V +AGL + E + L + ++A R GLEG + +P G Sbjct: 242 DTVVLIAGLFRGLVSHSVAAIEAGLPVELPRAELLRAATWRAARSGLEGDLVEPSGGGAG 301 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLN 343 P + RLL +I P G + L Q + + Sbjct: 302 PVPAEDLLGRLLAEIRPQLETAGDWELLTELAEQAIQRGS 341 >UniRef50_D2BAT9 Uncharacterized enzyme n=2 Tax=Actinomycetales RepID=D2BAT9_STRRD Length = 386 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 97/368 (26%), Positives = 163/368 (44%), Gaps = 4/368 (1%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F P +G+E E VV+P ++ +++ +++ ++ +V +IT +E T Sbjct: 11 PTFDALCPL-VGVEEEYLVVDPSTRAVAPEAAGVVERAAAEL-GEQVSTEITRFQVEAKT 68 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 C DI++ G+ M+ + AA L + GT + + D+ RY ++ + Sbjct: 69 PPCADISELEGRLRRMRSAMAAAARAGGLAVVASGTPVLGEVVPPPITDHPRYDVGIDTY 128 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L + ++ HVHV + A+ + + L ++P IAL A SP+ G DT +AS R Sbjct: 129 RALHDEQSICAGHVHVHLPDRERAVLVSNHLRPWLPVLIALMANSPFWAGRDTGYASWRT 188 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 + +P GP P+ ++ +FE L L+ ++ + WDIRPS T+EVRV D Sbjct: 189 LSWGKWPVAGPPPYFASLAEFEELIGTLTGAGVLVDPGTIFWDIRPSARLPTLEVRVTDV 248 Query: 244 PLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 P T + +A +++A L + L + +QA R GLEG DP T Sbjct: 249 PATAEESALLAAVVRALVVVSLERVDSGDPGPRLSAELLRAAYWQAARDGLEGQGIDPLT 308 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 G P E LL I PS + G + A +++ + + A R G + Sbjct: 309 GRLAPAAELCEALLRHIGPSLERTGDLETVTARLKRLRAAGSGAARQRAAHDRRGRPADV 368 Query: 362 VKKHCEIW 369 V Sbjct: 369 VDHLIGHL 376 >UniRef50_B1VHM9 Carboxylate-amine ligase cu1720 n=8 Tax=Corynebacterium RepID=CAAL_CORU7 Length = 394 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 84/337 (24%), Positives = 162/337 (48%), Gaps = 3/337 (0%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 T+G+E E+ +++P DL + L+D + V + + +E+ T V Sbjct: 4 PGSEPTVGLEWEVALIDPETLDLVPRAGELLDLMDEVYPGHRVTREFMANTVEMVTTVHG 63 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 +I A +L A + + GTHPF W QE+ D + YQ +E Y Sbjct: 64 NIPAAVEDLREQLLQLLDCADRIGVLLFSAGTHPFTNWGDQEMSDKKSYQEIIERTQYWG 123 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +Q ++G HVHVG S + +++ + PH +A+SA+SP +G DT +AS+R ++ Sbjct: 124 RQMIIWGIHVHVGVGSKEKVWPIINAVMTHYPHVLAMSASSPAWEGLDTGYASNRTLLYQ 183 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 P G ++W ++E R + +I+ +H+D+RPS +GT+EVR D+ + + Sbjct: 184 QLPTAGIPYQFASWDEWEEFNRDQDRSGVINHTGSMHFDVRPS-KYGTIEVRFADSTMAI 242 Query: 248 SHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 ++ + + + + + N+++A RYGL+ +I R Sbjct: 243 WEVAAISAYLHCLVVYFERMYDAGEELPSLQQWHVAENKWRAARYGLKALIITDRETTER 302 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGL 342 +T++ R +E+++P A ++G + ++ + R + +G Sbjct: 303 MVTDELRRWVEELSPLAEELGCKAELQDVLRLIETGG 339 >UniRef50_D2PXZ1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PXZ1_9ACTO Length = 351 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 86/352 (24%), Positives = 152/352 (43%), Gaps = 7/352 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 ++G+E E+ +V + S AVK + +V+ ++T + +E+ VC ++ Sbjct: 4 PSMGVEEELLLV-SASGEPLPRS----KAVKEEAEGVDVELELTRAQVEINAPVCDSSDE 58 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + + AA + + P + Q V RYQ +G L ++ Sbjct: 59 LRRHLVDGRTKLAAAAAEEGARLLAVAAPPSGQ-ALQLVTKKPRYQEMEARYGQLAREQG 117 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVH+ A+ + + L ++P +AL+A S G DT F+S R ++S +P Sbjct: 118 VCGCHVHIDVPDKAAALRVSNHLRPWLPALLALTANSAVYLGEDTGFSSWRWIMWSRWPC 177 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G P+ + + ++ L R I + ++WD RPS H T+EVRV D PLT+ V Sbjct: 178 AGQPPYFESVEHYDRLVRTHLAAGSIMDERMVYWDARPSTHLPTLEVRVSDVPLTVDETV 237 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 +A L +A L + E + + + A R GL G D P+ + Sbjct: 238 LIATLSRALVMTALADGG-PGPELQPEVLRAAYWLAARDGLTGDSVDVLNAQPMPMVDVQ 296 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 L E + P+ ++G +E ++++ N A R + G + L + Sbjct: 297 KLLREHVQPALEELGDLELVEETTERLLTDGNGAVRQRRAFRESGDVTALAE 348 >UniRef50_D1SDE2 Glutamate--cysteine ligase GCS2 n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SDE2_9ACTO Length = 380 Score = 326 bits (837), Expect = 6e-88, Method: Composition-based stats. Identities = 87/363 (23%), Positives = 148/363 (40%), Gaps = 5/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +++P + + + A+ + + + SM+E+ T V D+ + Sbjct: 19 LTLGVEEEFLLLDPATGESMPVADRVRGALSG-TAREQSRQEFRHSMVEMVTPVSPDLGE 77 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 +++ QAA + G P + R V D +RY FG + Sbjct: 78 LREHLVTLRQAAAQAADAAGARLVAVGATPVCEAHRT-VPDEQRYHDMSRRFGPVAHDPA 136 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 V G HVHVG + A+ + + L ++P AL+A SP G DT AS R +P Sbjct: 137 VCGCHVHVGVPDRELAVQVCNHLRPWLPVVQALTANSPLHDGRDTGHASWRSMQLERWPS 196 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 GP P + ++A L ++ ++W RPS + TVEVRV D T+ V Sbjct: 197 IGPTPHFESAADYDATVADLITAGIMLDAAMVYWYARPSAAYPTVEVRVGDVCPTVDDTV 256 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +AGL++A L+ + L ++A G++G + D +G RP + Sbjct: 257 LVAGLVRALVATLIDDVRAGVPAPRIRDCLVAAAHWRAAHDGVDGKLVDLRSGRPRPAWD 316 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA-DGGSLIGLVKKHCEI 368 L+ + P+ + G + +V A R +A GG + ++ Sbjct: 317 LVDDLVVTVTPALARHGDLDLVRRELDRVRRDGTGATRQRRIMAGTGGDVRAVLDHLAAQ 376 Query: 369 WAG 371 Sbjct: 377 TVS 379 >UniRef50_Q0F2E7 Putative uncharacterized protein n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0F2E7_9PROT Length = 371 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 104/368 (28%), Positives = 169/368 (45%), Gaps = 5/368 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F S P TLG+E+E V+ + + + AV + +K ++ S +E Sbjct: 5 MRTIAFQDSSPGTLGVEMEWMTVDINSGEQVPAAPAVFAAVGE---SARIKPELFTSTVE 61 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + TD+ R + A + A+ V Q H + GTHP W+ Q+V D++RY R L Sbjct: 62 INTDIHRSTSAAVDELQALYDQVSQILGGQHAALLSAGTHPTSHWRDQQVTDDQRYARLL 121 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +++++ +FG HVH+G GD I ++ L +P F+A+SA SP+ QG DT ++ Sbjct: 122 ERLQWMVRRFNIFGIHVHIGMPDGDTCIRAMNHLLPIMPVFLAISANSPFWQGEDTGLSA 181 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR +F G + NW+ FE L T IDS++D+ W++RP P FGT+EVR+ Sbjct: 182 SRIKVFEGLSQGGMPFYFENWRDFEHCAGRLQATDSIDSVRDIWWEMRPHPDFGTLEVRI 241 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D P + + ++A A + L + NR++ACRYG+ G + DP Sbjct: 242 GDMPGSRADTQAYIAYVRAEAMAAMHT--EAVPRVHPSLIRENRWRACRYGMHGTMIDPF 299 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 T P+ + L +A + + A + R A + Sbjct: 300 TERLMPVLDWLEMRLGALAAGGIEQSELELVAGRIGHWRKHAGGAAMQRQLHATHAAFPA 359 Query: 361 LVKKHCEI 368 ++ E Sbjct: 360 MIAAMREQ 367 >UniRef50_Q2RRI3 Carboxylate-amine ligase Rru_A2462 n=23 Tax=Alphaproteobacteria RepID=CAAL_RHORT Length = 389 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 101/376 (26%), Positives = 165/376 (43%), Gaps = 15/376 (3%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLI----DAVKNKITAGEVKHDITESMLELATDV 65 FT+GIE E +V+ L+ D + A G V + + +E+ T V Sbjct: 4 PAFTVGIEEEYLLVDRQSRALAADPPEALMTRLAAAFGDTNHGAVTPEFLRAQIEVGTKV 63 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 C + +A A+++V+ + A L THPF +W + ERY E+ Sbjct: 64 CDSLAEAGEALGALRRVLAEEAKGFGLAPIAASTHPFAEWADLKHTPKERYDLLAEDLQA 123 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 ++++ + G HVHVG D + L+ +S F+PH +AL+ +SP+ +G D+ S R + Sbjct: 124 VVRRLVICGMHVHVGIEDPDLRMDLMAQVSYFLPHLLALTTSSPFWRGEDSGLKSYRIAV 183 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 FSA P G S++ +++ L +I+ + WDIRPS F T+E+R+ D Sbjct: 184 FSALPRTGLPDSFSSFAEYQRHVEVLVSAGLIEDSTRIWWDIRPSHRFPTLEMRIADVCT 243 Query: 246 TLSHAVNMAGLIQATAHWLLTERPF--KHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 L A+ +A L + L R + + LL NR++A RYGL+G + D G+ Sbjct: 244 RLDDALCVAALFRCLLRMLYRLRRANQRWRHYARLLIAENRWRAQRYGLDGGLVDFGRGE 303 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA--------DG 355 P + LLE IAP A G + + R ++ A A Sbjct: 304 VVPFADLIEELLELIAPDAAVFGCQAEVLH-ARTILHRGTSAHNQLRVFAEARAGGMTRD 362 Query: 356 GSLIGLVKKHCEIWAG 371 +L+ +V Sbjct: 363 EALVAVVDHLIAQTVA 378 >UniRef50_C6WA32 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WA32_ACTMD Length = 363 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 96/366 (26%), Positives = 158/366 (43%), Gaps = 6/366 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +++P+T+G+E E +V+P + + D +V+ ++T +E+AT VC Sbjct: 1 MTQPWTVGVEQEFLLVDPQTRRPVPLAEAVADRAGASF---DVQRELTPFQIEVATPVCH 57 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + A Q A ++ + +AA + P + ++ RY R ++ Sbjct: 58 SSAELAEQVLAGRRHLAKAARAAGGALMASAVPPLGMTGPPSITEDARYLRMQYTHRKML 117 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 V G HVHVG + AI + L ++P +ALSA SP +G DT ++S R ++S Sbjct: 118 AGQGVCGMHVHVGVPDRETAIRASNALRPWLPSLLALSANSPVEEGQDTGYSSWRSIVWS 177 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P + ++AL L T ++ ++WD+RPS H TVE+RV D PLT Sbjct: 178 RWPVGGPPPQFTGAGHYDALVSALVGTEVVLDPAMVYWDVRPSTHVPTVEIRVADIPLTA 237 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV +A L++A P + + +L + ++A R G +G DP TG P Sbjct: 238 KDAVVIAELVRAFVRTAADSAPTE--PVNDVLLRAAYWRAARDGADGQGIDPRTGSLVPA 295 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG-GSLIGLVKKHC 366 + LL + GA + V A R +G +V Sbjct: 296 RDLLAELLAFGEDALRDAGAQDLVRGHLAAVAEHGGGAAKQRRAFLNGEADPADVVDLVL 355 Query: 367 EIWAGD 372 D Sbjct: 356 AETTAD 361 >UniRef50_D1RSS0 Carboxylate-amine ligase ybdK n=4 Tax=Enterobacteriaceae RepID=D1RSS0_SEROD Length = 369 Score = 324 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 134/369 (36%), Positives = 206/369 (55%), Gaps = 5/369 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M LP F SE TLG E+E+Q+V+ YDLS + +++ V +K +KH++T+SM+E Sbjct: 1 MSLP-FKCSERLTLGTEIELQLVDNDSYDLSHKADRVVEDVDDK---KRIKHELTKSMVE 56 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L + V DI + + + + + +A ++CGGG H W++Q + D+ERY Sbjct: 57 LNSSVHTDIGELLAELNELTGKIRASAQRIDCDVCGGGRHLSNDWRQQVITDSERYTLLA 116 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 FGYL + A VFGQH+H+G GD+A+YL H ++ ++PH IALSA+SP QG DT FAS Sbjct: 117 SRFGYLSKLACVFGQHIHIGVNDGDEAMYLCHAMTPYLPHLIALSASSPLYQGVDTLFAS 176 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 SR + ++FP+ G + + NW +F + L+ +I+ IKD++WD+RP P GTVEVRV Sbjct: 177 SRFSAQNSFPNYGCLEQIYNWDEFTVYYERLTSAGVIEGIKDIYWDVRPKPELGTVEVRV 236 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 DTPL + HA +AG + A +LL R + + +N+ ACR+G DP Sbjct: 237 CDTPLHIHHAATLAGYCRLLARYLLDNRQ-RVIAEYVAFTNYNKINACRHGFGADYVDPA 295 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 T R LT L L + P ++ ++ + V LN+A +R +G Sbjct: 296 TLRRCSLTSHMLATLAALRPGVQNSEENALLDGVEHYVKIALNDADRIRRLRHNGLQQKE 355 Query: 361 LVKKHCEIW 369 ++K+ C Sbjct: 356 VIKQLCHEL 364 >UniRef50_C1YFK1 Uncharacterized enzyme n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YFK1_NOCDA Length = 390 Score = 321 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 95/366 (25%), Positives = 158/366 (43%), Gaps = 4/366 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 + + P T G+E E VV+P + + ++ ++ + + + + +E + VC Sbjct: 23 NRTVPPTFGVEEEFFVVDPGTRLILSRAPEVL--ANTRVLGDHLCGEFSRAQVEANSPVC 80 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 D +A A + + +AA L + GT + RY +FG L Sbjct: 81 DDAGEALRFLRAARGELDRAAGAAGLAVVASGTAVLGDPASVGTSEGRRYADITAHFGAL 140 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 + V G HVHVG + A+ + + L R++P +ALSA SP+ G DT ++S R + Sbjct: 141 RESHVVCGCHVHVGVPDRETAVAVGNHLRRWLPFLVALSANSPFHAGRDTGYSSWRTVAW 200 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 + P GP P++ + + E R LS + I + ++WD+R S H T+E+RV D T Sbjct: 201 NRLPSAGPPPFLRSLAEHEQAVRALSDSGAILDRRMVYWDVRLSDHLPTLEIRVSDVAAT 260 Query: 247 LSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 A+ +A L++ L + + ++A R GLEGV+ DP TG+ Sbjct: 261 AEEALLLALLVRGLTGRALADVLYGVPAPAIPDQALRAAVWRAARDGLEGVVPDPLTGEA 320 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P RLL P G + +L +V + + A R A G L +V Sbjct: 321 LPGHAAAERLLHAAMPGLLANGDADLASSLLDRVRAAGSGAARQRAVYARRGRLADVVDH 380 Query: 365 HCEIWA 370 Sbjct: 381 LVVQTR 386 >UniRef50_D0WKA5 Carboxylate-amine ligase n=1 Tax=Actinomyces sp. oral taxon 848 str. F0332 RepID=D0WKA5_9ACTO Length = 387 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 97/369 (26%), Positives = 161/369 (43%), Gaps = 5/369 (1%) Query: 3 LPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 F SE T+G+E E+Q+V+P L ++ ++ V+ + VK ++ ++MLE Sbjct: 2 SIAFRDSERSTVGLEWEVQIVDPKTLKLGHNAKWILAEVRRR-GCSLVKGEMHQNMLEFV 60 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + + + A L A + + GGG+HPF Q V + RY+ +E Sbjct: 61 SRKRVSVAECAADMEEAIDAALPYAEELGVGFSGGGSHPFAHPSDQPVSETARYRELVER 120 Query: 123 FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 Y +Q +FG HVHVG + + LS + H + +SAASPY DT +A +R Sbjct: 121 TRYWGRQMVIFGTHVHVGVEDRRKVAPIHNFLSAKIGHLLGISAASPYWDDVDTGYADNR 180 Query: 183 PNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 +F P G +++W E + L I ++ WD+RPSP FGT+EVR D Sbjct: 181 AMMFQQLPTAGLPMHLNSWGDLERIAGDLVDVGAIREYNEIRWDVRPSPGFGTIEVRACD 240 Query: 243 TPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + L+ +A + A + + L + N+++ RYG + + Sbjct: 241 SATNLAEIRAIAAFVHALVETASRELDAGRPLLSLPFHLLETNKWRGARYGAHAELVESA 300 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 G+ PL E LL I P+A +G + + A+ + S A +R G L Sbjct: 301 DGECAPLAETLPDLLAWIEPAAEFLGCAEDLAAVPELIAS--PAADRLRAAAGPDGDLKA 358 Query: 361 LVKKHCEIW 369 + + Sbjct: 359 VAAHALAEF 367 >UniRef50_A0R3T8 Carboxylate-amine ligase MSMEG_5590 n=6 Tax=Mycobacterium RepID=CAAL3_MYCS2 Length = 365 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 82/368 (22%), Positives = 155/368 (42%), Gaps = 6/368 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 +S T G+E E +V+P + + + + K +++ ++T +E AT+V Sbjct: 1 MSNNPTFGVEEEFLLVDPRTGEPIARNKAVAETAAAK--GVDLQLELTSCQVETATEVMD 58 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + + +++V AA + + G P + + RY+R FG + Sbjct: 59 NSDDLRKALLRLRRVATDAAETNGARLLAAGLPPTV-PHKFPITPTPRYRRIGHRFGMIA 117 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + + G HVHV S D AI + + L ++ +AL+A S +G+D+ +A+ R +++ Sbjct: 118 HEQGICGCHVHVEVPSRDAAIRVSNRLRPWLHLLLALTANSAIYRGSDSGYATFRSVLWA 177 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P+ + Q++A L ++WD+RPS F TVEVRV D P T+ Sbjct: 178 RWPSAGPPPFFDSEAQYDATVAMLEDAGAALDDGMIYWDVRPSNKFPTVEVRVSDVPATV 237 Query: 248 SHAVNMAGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH-TGDR 304 + V A L++A + + K +++ R GL+G D + Sbjct: 238 AETVLFATLVRAAVMTATEAEKNGEPVVPLTDYVLKAAYWKSARDGLDGRTIDLAESHAV 297 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKK 364 P E +E + P+ ++G + +V+ N A R ++ + Sbjct: 298 APTVELLTNFVEHLRPALEQLGEYDTVRGELARVIETGNGAMRQRRAFERRREAADVIDE 357 Query: 365 HCEIWAGD 372 + Sbjct: 358 LAAATIAE 365 >UniRef50_A8I5N7 Carboxylate-amine ligase AZC_2303 n=2 Tax=Xanthobacteraceae RepID=CAAL_AZOC5 Length = 386 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 80/379 (21%), Positives = 139/379 (36%), Gaps = 11/379 (2%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + + +S + GIE E VV+ + + ++ +S LE Sbjct: 7 LASREVRMSNDYRFGIEEEFFVVDAETKAALRRMPSGFFDALRDRLGDSITVELLQSQLE 66 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 +AT I A + ++ + + A +H L GTHP W RY + Sbjct: 67 MATAPTDRIGDALDELRDLRHIAGRVAAEHGLGFIAAGTHPTASWDNVRATKANRYDGLM 126 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 ++ L ++ V G HVHV D + ++ ++ ++PHFIALS +SP+ T Sbjct: 127 QDLQMLGERNMVCGLHVHVELPDPDLRVDVMRRITPYLPHFIALSTSSPFWGSRQTGLMG 186 Query: 181 SRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRV 240 R + P G + +E L I + W IRPS T+E+R Sbjct: 187 YRLAAYDELPRTGLPELFEDNAAYEEYVAALVGARAISDSSYVWWAIRPSQKHPTLELRA 246 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 D + AV +A L ++ +L+ E D + N+++A RYG+ G D Sbjct: 247 PDACTRVEDAVALAALYRSLVRFLVRHPEHHRHIGAVDRAIANENKWRAQRYGIHGSFVD 306 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA----- 353 + + +L+ +A A +G A+ L + A + Sbjct: 307 LAEQRAIQVRDALDQLIALVADDAEDLGCLDALLHLRTIPDA-GTSADMQIAVYQEAHHR 365 Query: 354 ---DGGSLIGLVKKHCEIW 369 G +L + Sbjct: 366 TGNRGEALQAVKTWLAHAT 384 >UniRef50_C5CC09 Carboxylate-amine ligase Mlut_16620 n=5 Tax=Micrococcaceae RepID=CAAL_MICLC Length = 398 Score = 317 bits (812), Expect = 5e-85, Method: Composition-based stats. Identities = 104/394 (26%), Positives = 164/394 (41%), Gaps = 26/394 (6%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVK------NKITAGEVKHDI 54 M LP F S TLGIE E+ +V+ +L ++ L+ A+ + + ++ Sbjct: 1 MTLP-FADSAQSTLGIEWELALVDAVSGELRSEAPDLLRALHVAEGLADDDVNPHMTSEL 59 Query: 55 TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE 114 ++ +EL T V ++ A + V AA + + GTHPF Q +E Sbjct: 60 LQNTVELVTGVHERVDAATADLGRIAARVADAAAARGISLFCQGTHPFADAIAQPSTPSE 119 Query: 115 RYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 RY R L+ Y +Q +FG HVHVG A+ +++GL VPH +ALSA+SP+ GT Sbjct: 120 RYDRMLDLTQYWGRQLLIFGVHVHVGLDDVSKAMPVVNGLVNRVPHLLALSASSPFWAGT 179 Query: 175 DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFG 234 DT + S R +F P G W+ FE + MI + + WD+R P G Sbjct: 180 DTGYQSQRTLLFQQLPTAGLPFQFQEWEDFERCVAQMEQVGMIADVTECRWDVRAVPRLG 239 Query: 235 TVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGL 292 TVE+R D TL + Q L ER + + N+++A RYG+ Sbjct: 240 TVEMRACDGLATLEEIAAVTAYTQCLVDDLSASLERGETVEVLPPWHAQENKWRAARYGM 299 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + + G + PL E +E++ P A ++G + + + + G A R Sbjct: 300 DATVIVDARGTQVPLAEHLPAEIERLTPVAERLGCEAELAGVQAMIDDG--GAARQRRVE 357 Query: 353 ADGGS---------------LIGLVKKHCEIWAG 371 A + L +V Sbjct: 358 AQALAGPPAEGEDADDAVAPLRAVVLDAAARTRA 391 >UniRef50_D1AAX9 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1AAX9_THECD Length = 371 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 12/370 (3%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVK--------NKITAGEVKHDITESMLELAT 63 + G+E E+ + +P G S ++ + + +T G ++ ++ LE+ T Sbjct: 4 RSFGVEEELLLFDPEGGAPRAMSGAVLHHARLQGEKVHTSPLTKGGMESELQREQLEICT 63 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 C +++ Q + +AA + I T P + ++RY++ + + Sbjct: 64 RPCTTLDELDRQVRRRRLAAARAAAAAGVRIAALATSPVA--AHPTLTPHDRYRQMADQY 121 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 + + + G HVHV +S ++ + +L + ++P +ALSA SP+ QG DT + S R Sbjct: 122 AQVADEQLICGCHVHVEVSSPEEGVGVLDRIGPWLPPLLALSANSPFWQGRDTGYDSWRR 181 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 +++ +P +GP + + R L T + +++D R S H+ TVEVRV D Sbjct: 182 QVWARWPSSGPAEPFRSADGYRRAVRALIETGALLDEGMVYYDARLSRHYPTVEVRVADV 241 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKD--YLLYKFNRFQACRYGLEGVITDPHT 301 + V +A L++ + + ++A R GL G + P T Sbjct: 242 CMRADDTVLIAALVRGLVETAARAHREGRPPVPVRTEVLRAAMWRAGRSGLSGALVHPVT 301 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 P L+E + P+ G +A+ L + + N A L R A G + G+ Sbjct: 302 WRPAPARTVLQALVEYLRPALEDAGDLAAVRELLQALARRGNGACLQRTAYARTGCISGV 361 Query: 362 VKKHCEIWAG 371 + + Sbjct: 362 IADAMDRTVS 371 >UniRef50_A6WDG9 Putative uncharacterized protein n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6WDG9_KINRD Length = 850 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 90/363 (24%), Positives = 161/363 (44%), Gaps = 7/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG E E+ +++ LS + ++ + ++ + +E TDV + + Sbjct: 1 MTLGAEEELHLIDLGSGQLSARAPQVLSRLDP----ASYSAELQRTTVETNTDVVTSLTE 56 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 + ++K +++AA L + GT P + E+ RY R E + L+ + Sbjct: 57 LREELLRLRKGLVEAAARDGLGVAAVGTAPRSTFTDFELTATGRYGRMQEQYRLLVDEQL 116 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 + G VHVG + D A+ ++ ++ +P +ALSA+SP+ G DT +AS R ++ +P Sbjct: 117 ICGTQVHVGVSDRDLAVEIMQRVAPSLPVLLALSASSPFWNGQDTGYASIRTTVWQRWPT 176 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 G + + Q++ L L + +I K ++D+RPS H T+E+RV D + AV Sbjct: 177 AGSTGPLESAAQYDELLADLIASGVIGDEKMAYFDVRPSSHAPTLELRVADACPLVDDAV 236 Query: 252 NMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG-DRRPLT 308 +AGL +A + + L++ +QA R GL G + D P Sbjct: 237 LIAGLFRAGVRAAELDVLAGRPRPQVPSPLHRAGIWQAARGGLSGNLLDGTEHPRPVPAP 296 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 E LL ++ P ++G + L ++ N A R + G L +V+ E Sbjct: 297 EAVRALLTRLRPQLEELGDWEEVAELTEATLARGNSADRQRAAFVERGELDDVVRLVVEE 356 Query: 369 WAG 371 G Sbjct: 357 TRG 359 >UniRef50_C4RCL6 Glutamate-cysteine ligase GCS2 n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RCL6_9ACTO Length = 372 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 149/360 (41%), Gaps = 3/360 (0%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E VV+ + ++ + A + V +IT LE TD C + + A Sbjct: 14 FGVEEEFLVVDAVTRAPAPRAAE-VVAAASASLGDRVSGEITTLQLETRTDACGTLGELA 72 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 Q +KVV A L + GT P + R R E + L + + Sbjct: 73 DQLDEARKVVADCARAAGLRVVATGTAPVAGAVPPPMTVGPRQSRGTETYRGLHDELALC 132 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 HVHV A+ + + L ++P + L+A SPY D+ +AS R ++ +P G Sbjct: 133 ALHVHVEMPDRQRAVLVGNHLRPYLPLLLTLTANSPYWDDRDSGYASWRTTVWGRWPVAG 192 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 P P + + ++ + R L + + WD+RPS T+EVRV D+ +T + Sbjct: 193 PPPVFDSAEHYDEVVRRLLDAGALVDRATIFWDVRPSERHPTLEVRVADSAVTAEDSARY 252 Query: 254 AGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 A L++A L + L + ++A R GL+G DP TG RP E Sbjct: 253 AALVRALVVHLAAVMDAGEPAPHVAGELLRVGYWRAARDGLDGEGLDPRTGRLRPAAELA 312 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 LL+ + P G + ++ + A+ R V GG+L +V E AG Sbjct: 313 RHLLDTVEPVLRAHGDYDPVAQWLERLGTDGTGARHQRAVVRRGGTLTDVVDHLAERTAG 372 >UniRef50_B4V462 Carboxylate-amine ligase n=2 Tax=Streptomyces RepID=B4V462_9ACTO Length = 381 Score = 310 bits (795), Expect = 4e-83, Method: Composition-based stats. Identities = 83/363 (22%), Positives = 148/363 (40%), Gaps = 5/363 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 P T+G+E E +V+ + + +++D E+ + T +E++T V Sbjct: 19 PLTVGVEEEFLLVDTRTLRVVPAAPLVLDTAAGLPH--ELHPEGTRYQVEISTPVAHSAV 76 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN-ERYQRTLENFGYLIQQ 129 + +A+++ + +AA H + + + D+ R + FG L Sbjct: 77 TLRAELAALRRTLARAARAHGCRLLAAPSPVVALEGPLHLTDDEPRQREQHRRFGALTDT 136 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 G+HVH+G D A+ + + + ++P IAL+A SP+ G DT AS R ++ + Sbjct: 137 LVSCGRHVHIGTLDVDTAVAVSNRVRPWLPTLIALAANSPFWGGRDTGHASWRAMAWAGW 196 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G P ++ F + L + K ++WD+RPS H+ T+E+R D + Sbjct: 197 PSAGLPPHFTSTAHFRRSVQNLLGSGAALDTKMVYWDLRPSGHWPTLEIRAPDMSPDIDT 256 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 AV A L +A L E + + R++A GLEG DP+TG P Sbjct: 257 AVLQAELARALVAKALQEISEHRPEPAIRDDVLRLARWRAAHDGLEGFGLDPYTGAELPA 316 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 LL+ +A G ++ + A R A L +++ + Sbjct: 317 AGLAEALLDHVAADLAVAGDLDHAAKTMAGLLRDGSGAHRQRAAYARRQDLNDVLRHLAD 376 Query: 368 IWA 370 Sbjct: 377 ETE 379 >UniRef50_A5ESE1 Carboxylate-amine ligase BBta_7205 n=5 Tax=Alphaproteobacteria RepID=CAAL_BRASB Length = 408 Score = 310 bits (795), Expect = 5e-83, Method: Composition-based stats. Identities = 77/370 (20%), Positives = 155/370 (41%), Gaps = 6/370 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++ GIE E + + D++ + + N T G+ ++ ++ +E+AT+V Sbjct: 29 EDVTEYSFGIEEEYFLADARTLDVAIRTPDDLFEAANWSTGGQAMREMLQAQIEVATNVH 88 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 D A + +++ V A + L I THP W+ + RY +E+ + Sbjct: 89 VDSRDAREELKFLRREVASVAGQYGLTILACSTHPTAMWRSSQPTPRPRYAEMMEDLRIV 148 Query: 127 IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIF 186 Q+ + G HVHV + ++ + ++P FIALSA+SP+ +T R + Sbjct: 149 GQRNMLCGMHVHVQLPDSERRFAVMRAMIPYIPVFIALSASSPFWNSRETGLKGYRLAAY 208 Query: 187 SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 P G ++ +++ L+ + ++ + W +RPS T+E+R D + Sbjct: 209 DELPRTGLPELFTSKPEYDRYVAALTRSGVMPDESHVWWAMRPSLRHPTLELRAPDVCTS 268 Query: 247 LSHAVNMAGLIQATAHWLL--TERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + AV +A L +A A L + + + N+++A RYG + + Sbjct: 269 VDDAVAVASLYRALARHLYLHPDLADAVGNVERAIAVENKWRAQRYGTDCLFV--AEEGP 326 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK- 363 E R++ IAP A + + +E + G + ++ + GG L +++ Sbjct: 327 VTGQEILNRMIADIAPHAEALDCLAEVERCRTIMQFGSSADYQLQAYRESGGELSAVLRW 386 Query: 364 -KHCEIWAGD 372 + + D Sbjct: 387 IEVATVSRSD 396 >UniRef50_D1A6U3 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1A6U3_THECD Length = 372 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 101/365 (27%), Positives = 157/365 (43%), Gaps = 4/365 (1%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 E G+E E V++ + +I+ ++ V +IT +E T C Sbjct: 4 DGEALRFGVEEEFLVIDRRTRATVAGAPAVIERAAARL-GDRVCGEITLVQVESRTRPCT 62 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 + AGQ +A + + AA L + GT + + R R F L Sbjct: 63 TAAELAGQIAANRAHLAAAADGGGLGVIASGTPVLGGAVPSPITEGPRQNRGNATFRGLH 122 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +A HVHV A + A+ + + L +P IAL A SPY DT +AS R ++S Sbjct: 123 HEAAFCALHVHVEMADRERAVRMSNHLRPHLPVLIALGANSPYWCERDTGYASWRTLLWS 182 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P GP P++ + + ++ L + + + ++ WDIRPS H T+EVRV D P+T Sbjct: 183 RWPVAGPPPYLESAEHYDTLVATMQEAGALVDVGNVFWDIRPSAHLPTLEVRVSDVPITA 242 Query: 248 SHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + +A L++A LL +R L + ++A R GL G D HTG Sbjct: 243 EESAALAALVRALITSLLPAVDRGEDGPHLRPELLRLAYWRAARDGLSGSGVDVHTGKLL 302 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P E RLLE P + G + R+++ + A R A GG L G+V Sbjct: 303 PAVELAERLLETARPGLERHGDLGRVTGWLRRLIEHGDGASRQRRA-ARGGGLTGVVDHL 361 Query: 366 CEIWA 370 + A Sbjct: 362 LQQTA 366 >UniRef50_A4XUP3 Carboxylate-amine ligase Pmen_2301 n=1 Tax=Pseudomonas mendocina ymp RepID=CAAL_PSEMY Length = 378 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 82/371 (22%), Positives = 150/371 (40%), Gaps = 12/371 (3%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 T GIE E + + +++ + V ++ + E+ T V + Sbjct: 2 TQSTFGIEEEYFLTDLTSRQVARRNVEAFATACQYELGERVTREMFAAQFEVVTPVLHSL 61 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 A ++ + + A + + GTHP +W+R D RY+ +++ + + Sbjct: 62 TDARQCLEGARRALARLAREFDCGVLAAGTHPLGQWRRVRATDMPRYRAIFDDYRMVASR 121 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + + G HVHVG A G D I L++ L+ ++P + LSA+SP+ G + S R + + Sbjct: 122 SVLAGLHVHVGVAEGVDRIRLMNRLTPWLPLLLGLSASSPFWNGRPSGLMSYRQAVCDEW 181 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P G ++ +++ + ++ T I S +L W+IRPS + T+E+R+ D L Sbjct: 182 PRMGIPDHFADEAEYQRYVQVMTDTGCIRSAANLWWNIRPSLRYPTLELRIADACPRLDD 241 Query: 250 AVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 A+ +AGL +A L + +L NR++A R GL G+ +P + Sbjct: 242 ALCLAGLFRAMVEHVQLTPHHAWCDDPLTRVLTLENRWRAKRQGLRGLFIEPASQRLLTF 301 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA--------DGGSLI 359 +LE+IA I R + A+ G +L Sbjct: 302 ATWLEEVLERIAIQVPASD--RWILEHARNLALHGGSAEAQLAEYRGARANGLEHGEALH 359 Query: 360 GLVKKHCEIWA 370 +V Sbjct: 360 QVVDSLMAQTE 370 >UniRef50_C0QT87 Carboxylate-amine ligase Francci3_0693 n=1 Tax=Persephonella marina EX-H1 RepID=C0QT87_PERMH Length = 362 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 168/359 (46%), Gaps = 9/359 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 DF S+PFT+GIELE+Q+V+ ++LS+ S ++ + + ++ SM+E+ T Sbjct: 4 DFRSSKPFTVGIELEIQLVDRGSFELSESSEIVFSNASEGLKK-LLHPELLTSMVEIVTP 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 VC +A K + D+ GTH F K + + +RY + LE F Sbjct: 63 VCETPEEAVSHIKNAVKEIDLIGEDYGFRSAALGTHVFAKKETIHITAKDRYLKLLEEFQ 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 L++Q ++G H+HVG + AI + +P F+A+S +SP+ G T S R Sbjct: 123 ILLKQFLIYGLHIHVGFPEKEMAIKAYNETLNNLPLFLAVSTSSPFFLGEFTGLNSFRTK 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 IF P G + ++ FE L+ L I SIKD+ WD+R P FGTVE+RV D+ Sbjct: 183 IFEQLPRAGIPEYFDSYSDFEKLYFTLLENGFIQSIKDIWWDVRIHPDFGTVELRVCDSN 242 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 + +A L QA + ++ + + K N++ A RY +EG + Sbjct: 243 PDMERIEFIATLFQAVCFYSSFSSGERYF---HQILKQNKWNATRYSVEGRFL--YREGT 297 Query: 305 RPLTEDTLRLLEKIA--PSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 + + +++++ ++G +E L + + +Q+M + GS+ L Sbjct: 298 VQIKKRIADIIKELKKTDILKELGTEKRMEKLSDIIGKK-SISQMMIEEYRKKGSIKEL 355 >UniRef50_D2S6F8 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D2S6F8_9ACTO Length = 386 Score = 303 bits (776), Expect = 8e-81, Method: Composition-based stats. Identities = 87/381 (22%), Positives = 140/381 (36%), Gaps = 25/381 (6%) Query: 12 FTLGIELEMQVVNPPGYDLS---------------------QDSSMLIDAVKNKITAGEV 50 T+G+E E+ VV+ G + + D G + Sbjct: 6 RTVGVEEELLVVDSSGRPVPLGPAALEVAARRGEGETVEEHDRAERGDDEAGGGDPVGRL 65 Query: 51 KHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 ++ LE T VC ++ A + AA D + + P + + Sbjct: 66 VPELKTQQLEFGTRVCTGLDDVAADLRHWRGRADAAARDVGARVAALASSPVR--VEPQS 123 Query: 111 CDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPY 170 ERY E F + G HVHV ++ + +L+ + ++P AL+A SP+ Sbjct: 124 TPGERYTEMAETFRLTAAEQLTCGCHVHVAVEDDEEGVAVLNRIRVWLPVLTALTANSPF 183 Query: 171 MQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPS 230 G D+ AS R ++ +P +GP ++ + L L T I +++D R S Sbjct: 184 WLGRDSGHASYRAQAWNRWPSSGPNELFADAAAYHRLVGELLATETIVDTGMVYFDARLS 243 Query: 231 PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQAC 288 + TVEVRV D L AV +AGL++ + + ++A Sbjct: 244 ERWPTVEVRVADVALRAEDAVTLAGLVRGLVETAAGQWRAGVPAPAVRSEVVRMAAWRAS 303 Query: 289 RYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLM 348 R GL G + P TG P LL + P+ G + A V+ A L Sbjct: 304 RSGLTGDLVHPATGRPAPAGAVVTALLAHVRPALAAAGDEQRVAAGVAAVLDRGTGADLQ 363 Query: 349 RDFVADGGSLIGLVKKHCEIW 369 R A G L +V+ E Sbjct: 364 RRVFAATGDLTAVVRAAVEAT 384 >UniRef50_A1RAU1 Carboxylate-amine ligase AAur_3665 n=4 Tax=Arthrobacter RepID=CAAL3_ARTAT Length = 424 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 6/345 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G+E E+ +V+P + + + H++ +E T C + Sbjct: 30 RTFGVEEELLIVDPVTGE--PLALADALLAGQDEPTSGLSHELKLEQIETQTRPCHSYGE 87 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 Q + + QAA H + T P + RY L+ FG + + Sbjct: 88 LLQQIRRGRAMANQAARQHGARVAAIATSPLA--SNTHTTPDPRYAAMLDRFGIIATEQL 145 Query: 132 VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPD 191 G HVH S ++ + +L + + AL+A SPY +G T F S R ++ +P Sbjct: 146 TCGFHVHTSVESPEEGVVVLDHIRDKLAVLTALTANSPYWRGLPTGFDSYRTQAWNRWPT 205 Query: 192 NGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 +GP + + + + L T +I +++D R S + TVEVRV D L A Sbjct: 206 SGPSSVFGSLTAYRRIVKRLLETGVIMDEGMIYFDARISRNHPTVEVRVADVCLRAEDAA 265 Query: 252 NMAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 MA L++A E + L + +QA GL G + D +P + Sbjct: 266 LMAVLVRALVETASLEMLDGVEPTAVPTALLRMASWQASNSGLRGDLLDFGDFLPQPAAD 325 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD 354 L++ ++P G ++A V+ N A R+ Sbjct: 326 VVWALVDYLSPVLDDQGELELVKAGISDVLDRGNGAHEQRETAVR 370 >UniRef50_A9IFL0 Carboxylate-amine ligase Bpet4705 n=8 Tax=cellular organisms RepID=CAAL_BORPD Length = 415 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 146/373 (39%), Positives = 208/373 (55%), Gaps = 4/373 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M F S P TLGIELE+Q++NP +DL+ + L+ + N A VK +IT SM+E Sbjct: 1 MEQIPFVSSAPNTLGIELELQLINPRSFDLAAAADELLAQMANHPIADRVKPEITRSMIE 60 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L + V + M+ + AA + + GGG HPF +WQ + + D+ R+Q Sbjct: 61 LNSSVHEHPMGLLAEMREMRDALCDAADAVGVSVAGGGAHPFMRWQERAISDSPRFQYLA 120 Query: 121 ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 E +GYL +Q TVFGQH+H+G SGD A+ ++ GLS +VPHFIALSA+SPY +G DT F+ Sbjct: 121 EMYGYLARQFTVFGQHIHLGVPSGDAAVRMVRGLSPYVPHFIALSASSPYYEGVDTLFSC 180 Query: 181 SRPNIFSAFPDNG-PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVR 239 R N S+FP G V++W +FEA L + +SIKDL+WDIRP P FGTVE+R Sbjct: 181 CRLNAVSSFPLAGHLPADVTDWYRFEAHIAQLRACGLAESIKDLYWDIRPKPEFGTVEIR 240 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 V DTPLT+ A +A L+T P +L Y+ N FQACR+GL+G P Sbjct: 241 VCDTPLTVERACQLAA-FAQALAVLVTREPEPAPAA-WLAYRSNHFQACRFGLQGSYVTP 298 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 G R L + L +++ P A ++G + AL + + N+A+ +R L Sbjct: 299 -DGQRLRLIDHLRALFQRLMPIADELGTGDMLVALRDESIRNGNDARWLRSQFHRLRDLP 357 Query: 360 GLVKKHCEIWAGD 372 +V+ W G+ Sbjct: 358 LVVESMTHAWRGE 370 >UniRef50_D0LDX8 Glutamate--cysteine ligase GCS2 n=2 Tax=Corynebacterineae RepID=D0LDX8_GORB4 Length = 374 Score = 297 bits (761), Expect = 4e-79, Method: Composition-based stats. Identities = 95/363 (26%), Positives = 157/363 (43%), Gaps = 5/363 (1%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 T+G+E E +V+P + + A + +++ ++T +E AT + Sbjct: 15 APTVGVEEEFILVDPATEHPVARNGEVAAAASRR--GVDLELELTSCQVETATAPHHAVA 72 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + + ++ VV AA + + + G P + D RY+R E FG L + Sbjct: 73 DLLDELTRLRSVVAAAAAEVGVGVIAAGAPPTVPVA-FPITDTARYRRIGERFGMLAHEQ 131 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV + AI + + L +P +ALSA SP + DT AS R ++S +P Sbjct: 132 GVCGCHVHVAVPDRETAIEVSNHLRHRLPVLLALSANSPVYRDADTGHASWRWVLWSRWP 191 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP P + + + FE+L + I ++WD+RPS H T+EVRV D T S A Sbjct: 192 AAGPPPHLRSREHFESLVTMFVASGAILDDHMVYWDVRPSDHLPTIEVRVGDVQPTASEA 251 Query: 251 VNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 A +++ L + E D + ++A G++G D TG+ P Sbjct: 252 AAFAAIVRGLTLTALRDIDAGIAAPEIDTAILDAAMWKAAHDGIDGAGIDVLTGESVPAL 311 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 + RL++ I+ + G + + A R + S N A R DG G+ Sbjct: 312 DLVGRLVDDISDALDAAGDADLVTAARRSLGSRGNGATRRRRDFRDGTDGPGIAGAAMAE 371 Query: 369 WAG 371 + G Sbjct: 372 FTG 374 >UniRef50_A1SLX8 Carboxylate-amine ligase Noca_3311 n=3 Tax=Actinomycetales RepID=CAAL2_NOCSJ Length = 369 Score = 296 bits (759), Expect = 6e-79, Method: Composition-based stats. Identities = 89/368 (24%), Positives = 147/368 (39%), Gaps = 10/368 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKN------KITAGEVKHDITESMLELATDV 65 T+G+E E +V+ +S + ++ AG + H++ E LE+ T Sbjct: 2 RTVGVEEEFLLVDADRSRPIPAASRALRVATEWGVAGGQVGAGALVHELQEQQLEIYTAP 61 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + + A + AA + T P + RY R E FG Sbjct: 62 QVRMASLETELRAWRAAAAAAAAAVGARLVASATSPVA--VEPHRVRSPRYDRMAERFGI 119 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + + G HVHV S +A+ +L + ++P +ALSA SP+ QG DT +AS R Sbjct: 120 VTDEQLTCGCHVHVAVGSTAEAVGVLDRIRVWLPALLALSANSPFWQGRDTGYASFRIQA 179 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 +P +GP ++ L + ++ L++D R S F TVE+RV D L Sbjct: 180 LGRWPLSGPTELFGTAAAYQELVERVLAAQVVLDQGMLYFDARASHRFPTVEIRVADVCL 239 Query: 246 TLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 + V +A L +A + +L + + A R+G+ + DP T Sbjct: 240 DVRDTVLIAALCRALVETSAARWAAGEAPPQVPAVLLRLATWHASRWGVSADLLDPMTAR 299 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 P E RL+E P+ + G + +++ N A RD A G L +V Sbjct: 300 PLPAAEVVGRLVEHARPALRRSGDDGLVADGIARILEHGNGATWQRDVFAGSGRLDEVVS 359 Query: 364 KHCEIWAG 371 + +G Sbjct: 360 ALALVTSG 367 >UniRef50_A4FHB5 Carboxylate-amine ligase SACE_4171 n=3 Tax=Actinomycetales RepID=CAAL2_SACEN Length = 391 Score = 296 bits (758), Expect = 8e-79, Method: Composition-based stats. Identities = 90/363 (24%), Positives = 145/363 (39%), Gaps = 7/363 (1%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE---VKHDITESMLELATDVCRDI 69 T+G+E E +V+ L+ + ++ N + ++ S +E AT CR + Sbjct: 22 TIGVEEEFLLVDAASGQLAPHAEAVLAEAANGPLGAPDAVLHAEMLNSQVEAATGCCRTL 81 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + Q A + + +AA+ I GT + +R+ E + + Sbjct: 82 EELRSQLVAARTSLDRAASVAGARIVSSGTPVLAVEG-TGTSNGQRFADIAERYRAVASD 140 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG D A+ +++ L ++P +A+SA SP+ G DT AS R + Sbjct: 141 YHVCGCHVHVGVPDRDTAVAVVNHLRPWLPTLLAISANSPFHLGHDTGHASWRGVQQRLY 200 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P +G P + ++ L + + W RPSPH TVE+RV D +T Sbjct: 201 PGSGVPPHFPSRDAYDREVARLVDCGALVDDRMSFWMARPSPHLPTVELRVADALITAEE 260 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 V A L +A L + + E + + A RYGL G DP R P Sbjct: 261 TVLQAALSRALVRAALDDLAAGREGDEVSDQVAAAAVWNASRYGLRGPAVDPVPARRVPA 320 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 E RLL ++ P+ + G S+ + V ++ R A G +V Sbjct: 321 LEMVERLLRRVGPALEQTGDSALVREALAHVTGVGTGSERQRAAAAAG-GPREVVAMLAA 379 Query: 368 IWA 370 A Sbjct: 380 ATA 382 >UniRef50_C9YX80 Glutamate-cysteine ligase family protein n=2 Tax=Streptomyces RepID=C9YX80_STRSW Length = 375 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 147/336 (43%), Gaps = 4/336 (1%) Query: 40 AVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 A+ ++ E K ++ S +E + V + + ++ + AA+ L + GT Sbjct: 6 AILGRLGGPEFKAELQRSAVEWNSPVHASLESLHTDLTGARRRLAAAASGLGLSVVAAGT 65 Query: 100 HPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 P + + + RY+ E + + + V VHV D A+ ++ +S ++P Sbjct: 66 VPLARLTPGDTTPDFRYRYMTEEYRRVADEHLVCSAQVHVDVPDRDTAVRIMCAVSPWLP 125 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 +AL+A+SP+ G DT +AS R ++ +P GP+ + +++A + L + +I Sbjct: 126 PLLALTASSPFWLGADTGYASWRTMLWQRWPTAGPVGCFAGAAEYDAAVQGLIRSGVIKD 185 Query: 220 IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATA---HWLLTERPFKHQEKD 276 +++D+RPS H T+E+R+ D V + GL +A LL P + E Sbjct: 186 SGMVYYDLRPSEHQRTLELRICDASPRPETVVLVTGLFRALVEDARGLLEREPERVCEGG 245 Query: 277 YLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHR 336 + + ++A R GLEG + DP T P +L ++ P+ G + L Sbjct: 246 HEWLRSAVWRAARSGLEGDLVDPVTRGAAPAPAVLRGMLRRLRPALEAAGDWDTVPVLLE 305 Query: 337 QVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 + ++ + A +R + G L V G+ Sbjct: 306 EALARGSAAHRLRRVAGERG-LPACVGTLVAETRGE 340 >UniRef50_Q18H65 Carboxylate-amine ligase HQ2566A n=10 Tax=Halobacteriaceae RepID=CAAL_HALWD Length = 363 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 90/362 (24%), Positives = 149/362 (41%), Gaps = 19/362 (5%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA---GEVKHDITESMLELATDVCRDI 69 TLG+E E VV+ + LI + + H++ + ++E T + D+ Sbjct: 14 TLGVEEEFFVVD-DSGQPTAGIQELIYDYNHPPAGVLADRLDHELFQFVIETQTPLLEDV 72 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 + + A++ ++ A DH I G HP KW+ + + RYQ L+ Y + Sbjct: 73 SAVSESVQAVRDALVTHAADHGYRIAAAGLHPTAKWRERNHVEKPRYQSQLDRIQYPQHR 132 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 T G HVHVG D A ++ + L ++P +ALSA SPY G DT AS+R IF A Sbjct: 133 NTTAGLHVHVGVDDPDAATWIANELRWYLPPLLALSANSPYWNGFDTGLASARAKIFEAL 192 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P+ G +++ + L + + T I +L +D+RP GTVEVR D S Sbjct: 193 PNTGMPTRFEDFEAYYQLEKRMVETGSIKDRGELWYDVRPHTGHGTVEVRTPDAQADPSV 252 Query: 250 AVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 V + I A + + N++ A RYG + P + + L Sbjct: 253 TVAIVEYIHALVMDFAARYADGESGTKVRREILDANKWHAMRYGRDAEFIIPGSMETVTL 312 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 +E R ++ ++ L + A+ R A ++ L++ C Sbjct: 313 SEFVDRETNRLG-----------VDGLTTLLAREG-GAKKQRRLHASD-NIDTLLESLCL 359 Query: 368 IW 369 Sbjct: 360 DT 361 >UniRef50_UPI0001C32130 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32130 Length = 382 Score = 292 bits (749), Expect = 1e-77, Method: Composition-based stats. Identities = 103/351 (29%), Positives = 160/351 (45%), Gaps = 9/351 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F +PF+LG+E E+ +V+P + S+ +ID + G V+ ++ +EL TDV Sbjct: 15 FGEGDPFSLGVEEELFLVDPVTGEQINASTAVIDRLG--PVDGRVERELHACQVELITDV 72 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 CR +A G ++ V+ + + G GTHP + E+ D RY+R E G Sbjct: 73 CRTAGEAVGTLGGLRAAVVAT----GVGLLGAGTHPAAEEGDAEITDKVRYERIRELLGD 128 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + V G HVHVG + AI +GL R +P AL A SP+ DT AS+R Sbjct: 129 AVATP-VNGLHVHVGMPDAETAIRAFNGLRRHLPLLQALGANSPFRHSRDTGLASAREVT 187 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 +P +G + +++ F A+ L+ + W +RP P GTVE+R +DT Sbjct: 188 TRGWPRSGVPRAMRDFEDFCAMSALLARAADVPDYTWFWWKLRPHPRLGTVEIRALDTQT 247 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +L + L+ A + L F+A RYG++ + D G R Sbjct: 248 SLEDLAALVALVHCLARHASELGADPAADPPGELLDEGVFRAARYGIDAQLPD-AEGRLR 306 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 P+ ++E +AP A ++G ++ LHR V G A R A GG Sbjct: 307 PVRSLLDDVVEMVAPDARELGCEGELDGLHRLVERGG-GAGRQRSLHAIGG 356 >UniRef50_A1SKY7 Carboxylate-amine ligase Noca_2970 n=1 Tax=Nocardioides sp. JS614 RepID=CAAL1_NOCSJ Length = 382 Score = 292 bits (749), Expect = 1e-77, Method: Composition-based stats. Identities = 82/370 (22%), Positives = 148/370 (40%), Gaps = 12/370 (3%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITA--------GEVKHDITESMLELAT 63 LGIE E+ + +P ++ + ++ + E+ ++ LE T Sbjct: 3 RKLGIEEELLLFDPESGEVVPAAPSVLKEFREHGPGRQRARAATDELDQELFRHQLETRT 62 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 D R A Q A ++ +AA G P R V N+RY+ ++ + Sbjct: 63 DPVRRAADALDQLVAARRTAGEAARAAGYAAGACGIVPLGG-DRSVVSPNDRYRDMVDTY 121 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 G + + G HVHV S ++ + ++ ++ ++P +AL+A SPY++G D+ +AS R Sbjct: 122 GEIARTGGTCGMHVHVDIGSDEEGVAVVDRIAPWLPVLVALAANSPYVEGRDSGYASWRA 181 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDT 243 +++ +P GP + + + R L L++D R S TVEVRV D Sbjct: 182 QVWARWPSAGPTEQFGSVAGYREVCRMLLDVGAARDPGMLYFDARLSTGQPTVEVRVCDV 241 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVITDPHT 301 + AV + L++A E + + ++A R+G+ + P Sbjct: 242 GTDPAVAVTIGALVRALVETAAEEWADGRPAAHWRAEALRAAHWRASRFGMADSLVHPLA 301 Query: 302 GDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGL 361 RP L+E + P+ G ++ + V+ N A R GS+ G+ Sbjct: 302 RGLRPARSVVAALVEAVEPALAAAGDLELVDVQLERAVND-NGATRQRAAFERTGSVRGV 360 Query: 362 VKKHCEIWAG 371 V Sbjct: 361 VDDVIARTEA 370 >UniRef50_C6WJM5 Glutamate--cysteine ligase GCS2 n=1 Tax=Actinosynnema mirum DSM 43827 RepID=C6WJM5_ACTMD Length = 383 Score = 290 bits (743), Expect = 5e-77, Method: Composition-based stats. Identities = 91/347 (26%), Positives = 142/347 (40%), Gaps = 9/347 (2%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G+E E +V+P + + ++ AV++ + ++ S +E AT VCR + Sbjct: 5 TFGVEEEYLLVSPETSLPTASAPEVLAAVRDLPPGAMAQPELLSSQVEFATGVCRTAPEL 64 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 Q A + V AA + G P R V RY+ + L+ Sbjct: 65 REQLRAGRSAVADAAGRVGVLPVAVGNPPL--PGRVPVTRGSRYREITSLYQGLMTDYQC 122 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + +L L ++P +ALS SP+ +G DT + S R S+FP Sbjct: 123 CGCHVHVGVPDRATGVAVLDHLRPWLPTLLALSVNSPFDRGEDTGYGSWRAVRQSSFPGW 182 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G P + ++ + L T ++ W R SP + TVEVR DT T+ AV Sbjct: 183 GVPPLLRTVERHDRLVEAAVDTGVLVDPTMTFWLARLSPKYPTVEVRAADTAATVDGAVL 242 Query: 253 MAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 A L +A L ER + + + + + A R+G G DP TG + Sbjct: 243 QAVLTRALVDTALAALERGEEAPDHEPAVLTAALWSAARHGTAGQGVDPTTGRAVRAEDL 302 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 LL + P+ + + L + G + A L R DG + Sbjct: 303 ARALLAHVRPALDA--DAGWVADL---ALRGRSGAALQRAAGDDGAA 344 >UniRef50_Q1AWY5 Carboxylate-amine ligase Rxyl_1127 n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=CAAL3_RUBXD Length = 384 Score = 290 bits (742), Expect = 7e-77, Method: Composition-based stats. Identities = 92/375 (24%), Positives = 153/375 (40%), Gaps = 14/375 (3%) Query: 1 MPLPDFHVSEP-FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESML 59 +P F P TLG E E+ + +P L+ + ++ A A ++ + + Sbjct: 15 LPEEAFETGAPEGTLGAEEELWLADPETLKLAGGAQKILAA----EPAEHFSGELIDCEV 70 Query: 60 ELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRT 119 E T V R+ A A ++ +L+ A + GTHP W+ QE+ D YQ Sbjct: 71 EANTGVHREAAGVARDLLARRRTLLEHAGRLGRVLGTSGTHPLGDWREQEIIDKPHYQYL 130 Query: 120 LENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFA 179 G+LI++ F HVH + IYL + +VPHF+A+S SP+ QG T Sbjct: 131 KRKLGWLIRRNNTFSLHVHYAVQGKEKVIYLFDRIREYVPHFLAVSVNSPFWQGEFTDTR 190 Query: 180 SSRPNIFSA-FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 S+R +FS P G +W + + +I + ++ WDIRP P T+E+ Sbjct: 191 SARALVFSRSLPHAGMPEAFGSWSAYAGYLDFVGRPGVIRRLGEIWWDIRPHPRLSTLEI 250 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 R D + + + L AT L E + + N++ A R+GL+G+ Sbjct: 251 RAFDAQTDPARSEALISLAAATCDMLCAEYESGELRPARPVREIEDNKWSAQRHGLDGLF 310 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 D T + P RL E A S S + +++ E++ + G Sbjct: 311 VDHETHEPVPARWAVERLAELAASS------SRRDLSSLERLLEEPTESERQLLVWRETG 364 Query: 357 SLIGLVKKHCEIWAG 371 S+ + + Sbjct: 365 SVKEVARDIARRTRA 379 >UniRef50_UPI0001C32412 glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C32412 Length = 381 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 98/370 (26%), Positives = 154/370 (41%), Gaps = 12/370 (3%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAV-KNKITAGEVKHDITESMLELAT 63 F S FT+G+E E V++P L+ L DA + + A + ++ S +E+ + Sbjct: 11 AFEDSTDFTVGLEEEFAVLDPGTRALTPRFEELRDAAQADPVLAESIAGELISSEIEIRS 70 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 D+ AA + ++ + A + + + GTHPF ++ Q + D E Y R + Sbjct: 71 GKGVDVADAAIRQRDHRRRLFALAQERGIALGATGTHPFSDYREQRIIDTEHYHRVEDGL 130 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 Y+ + F HVHVG D A+ + L +P +A+SA SPY+ G D+ + R Sbjct: 131 KYVAWRNNTFSLHVHVGVQGADRAVQVCDRLRPVLPLLLAISANSPYVDGRDSGLHTVRT 190 Query: 184 NIF-SAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMD 242 F +FP G +WQ F + L T I + W +RP FGTVEVR+ D Sbjct: 191 QTFTKSFPRCGVPDAFGSWQAFRSYLEFLVATNSIVEYTQVWWSVRPHLSFGTVEVRICD 250 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 T + +A LI A + + L + N ++A R GL+G + D Sbjct: 251 AQSTAGESDGLAALIVACVAQAARDVEDGVPFADPPARLIEENMWRAIRRGLDGPLIDLE 310 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIG 360 P RLL AP ++G A+ L N AQ R + G + Sbjct: 311 RAVEFPGQAALERLLAWTAPVRAELGIDVALPEL--------NGAQRQRRMIDAGAGIEE 362 Query: 361 LVKKHCEIWA 370 + Sbjct: 363 VYAATVRETR 372 >UniRef50_Q1I926 Carboxylate-amine ligase PSEEN3084 n=4 Tax=Pseudomonas RepID=CAAL_PSEE4 Length = 380 Score = 289 bits (740), Expect = 1e-76, Method: Composition-based stats. Identities = 76/370 (20%), Positives = 149/370 (40%), Gaps = 12/370 (3%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 ++ P+T GIE E + + + S + ++ ++ S +E+ + V Sbjct: 1 MARPWTFGIEEEYLLADTTSGQVLASPSPAVTRRCREMLGATFAEEMFLSQIEVVSPVFD 60 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 ++QA ++ + +A D + + G +HP +W RQ +++ +++ + Sbjct: 61 SLHQARSFLGENRQRLGEALGDFGVGLYGAASHPCAQWLRQHPRGTAHFRQLFDDYRLVA 120 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 +++ V G HVHVG +G D + L++ + ++P F+ LS +SP G DT + S R I Sbjct: 121 RRSLVNGLHVHVGVPAGTDRMQLINRVLYWLPLFLVLSTSSPLWGGQDTGYMSYRRVICG 180 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +P G +++W ++ L T + D W IRPS F TVE+R+ D L Sbjct: 181 EWPHMGLPEPLADWHAYQRYRGLLQRTGALAEDGDFWWAIRPSRRFPTVELRICDGCPRL 240 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKD-YLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + +AGL + L ++ + + N ++A RYG G Sbjct: 241 EDGLAIAGLYRHLVQHALARHDGMAVSREIRWITQENYWRAARYGRRGTFIGAVDQQPVS 300 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV--------ADGGSL 358 +L + + R+++ A R+ A +L Sbjct: 301 AEGWLAQLQSWLP---ADSAEAERSFMQARRILREGTSADRQREAYALARENGLAGREAL 357 Query: 359 IGLVKKHCEI 368 + ++ Sbjct: 358 RAVARQVMAE 367 >UniRef50_Q9KY07 Carboxylate-amine ligase SCO7331 n=5 Tax=Streptomyces RepID=CAAL_STRCO Length = 363 Score = 289 bits (740), Expect = 1e-76, Method: Composition-based stats. Identities = 84/363 (23%), Positives = 153/363 (42%), Gaps = 5/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAV-KNKITAGEVKHDITESMLELATDVCRDIN 70 T+G+E E+ +V+P + S+ ++ + + ++ E MLE AT D+ Sbjct: 2 RTVGVEEELLLVDPATGEPRALSAAVLARAFLDDSEQDVFEKELHEQMLEFATHPQADME 61 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 + + ++ + A + T P + N RY+ E +G ++ + Sbjct: 62 RLHAEIVRCREEAGRHAGGIGCAVAALATSPL--PVTPSIGVNRRYEWMAEQYGVVVHEQ 119 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV S ++ + ++ + ++P ALSA SP+ QG D+ ++S R ++ +P Sbjct: 120 LVLGCHVHVSVDSDEEGVAVIDRVRPWLPVLAALSANSPFWQGRDSSYSSYRSRVWQRWP 179 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 GP + +++ + T + +++D+R S + TVE RV D L S A Sbjct: 180 SAGPTELFGSAERYHRRVADMLATGTVLDDGMVYFDVRLSQRYPTVEFRVADVCLDASTA 239 Query: 251 VNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 V +A L +A E + E L + ++A R GL + P T R P Sbjct: 240 VVLAALARALVDTAAREWRAGAEPAEHSVSLLRLAAWRAARSGLTSELLHPATMRRMPAE 299 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 LLE + G + +++ N A++ R+ +A GSL +V Sbjct: 300 SVVRDLLEHAGEALAAAGDLERVREGVEKLLRHGNGARVQRELLARTGSLREVVAACVRR 359 Query: 369 WAG 371 Sbjct: 360 TQA 362 >UniRef50_UPI0001B5549F hypothetical protein SSPB78_30119 n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B5549F Length = 381 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 90/342 (26%), Positives = 145/342 (42%), Gaps = 7/342 (2%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVK---HDITESMLELAT 63 S P TLG E E +V+ + ++D G V ++ SM+E + Sbjct: 16 AHSAPPTLGAEEEFLLVDAETLVPVDAAERVLDVHHRLHPKGAVTVPQRELLSSMIETTS 75 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 VC + + + SA ++ +++AA + GT Q R + Y+ + Sbjct: 76 PVCAGLPELRAEVSAARERLVEAAAKAGCRVLAHGTAARQAPPRTP-TEAPHYRDVAGLY 134 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L Q G H+HVG + A++ L + ++P +ALSA SPY G DT FAS R Sbjct: 135 RLLAQGTETCGCHIHVGVPDREAAVHALDHVRPWLPVLLALSANSPYEHGVDTGFASWRT 194 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSI-KDLHWDIRPSPHFGTVEVRVMD 242 + S +P P+ ++ ++A R L T ++ ++ +W RPS H T+EVRV D Sbjct: 195 MVLSRWPTTQIPPYFTDAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEVRVAD 254 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITDPH 300 T+ AGL +A L ER + + A RYGL G + P Sbjct: 255 VMPTVREVAAQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSLVHPG 314 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGL 342 +G P E LL + + +G + A+ R ++ Sbjct: 315 SGTAVPAGEAVAALLAHVGEALADLGDEEEVTAVVRDLLHRG 356 >UniRef50_C0XRA9 Glutamate--cysteine ligase, Gcs2 n=1 Tax=Corynebacterium lipophiloflavum DSM 44291 RepID=C0XRA9_9CORY Length = 854 Score = 286 bits (733), Expect = 7e-76, Method: Composition-based stats. Identities = 79/357 (22%), Positives = 148/357 (41%), Gaps = 7/357 (1%) Query: 18 LEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFS 77 E+Q+V+ L+ + +L+ ++ A +++ SM+++A+ D+ + Sbjct: 5 EELQLVDKETRRLAPKADVLLSQLEGDAFAPSIQN----SMIQVASGSHGDVTSLRDELL 60 Query: 78 AMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHV 137 + A L I GT P + RY ++ L ++ + + Sbjct: 61 QGRARASSVAEPLGLAIAAAGTMPLAHRASLAITPRSRYMEMSADYALLAREQLICSAQI 120 Query: 138 HVGCASGDDAIYLLHGLSRFVPHFIALSAASPY-MQGTDTRFASSRPNIFSAFPDNGPMP 196 HV D A+ + G+SR +P +ALSA+SP+ ++G+DT +ASSR +P +GP Sbjct: 121 HVEVRDRDQAVAVSPGVSRHLPLLLALSASSPFSVEGSDTGYASSRDLTGQRWPTSGPFA 180 Query: 197 WVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGL 256 VSN ++++ L L +I +++ + PS +E+RV D+ ++ +A L Sbjct: 181 PVSNAKEYDELVDTLIKAGVIADEAMMYYSLAPSVSKPLLELRVCDSCPSVDAISTIAAL 240 Query: 257 IQATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRL 314 +A L + + L++ ++A R GLEG + P T RP E Sbjct: 241 FRAMVVREAALVDASTPTPPLNPTLHRSMMWRASRSGLEGSLICPETYTPRPAAEVLRST 300 Query: 315 LEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 +E + G + ++ A R G L +V + G Sbjct: 301 VELLTDELRASGDLEMVTRFVEGIIRTGTSAYRQRRAYRSRGRLDDVVDQLMSETVG 357 >UniRef50_B4V111 Carboxylate-amine ligase RHA1 n=2 Tax=Streptomyces RepID=B4V111_9ACTO Length = 391 Score = 285 bits (730), Expect = 2e-75, Method: Composition-based stats. Identities = 93/364 (25%), Positives = 148/364 (40%), Gaps = 8/364 (2%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+ + +I+A + V+ + M+E+ T Sbjct: 27 PTLGVEEEFLLVDRLTRAPVPRAGPVIEAASYFL-GDLVQEEFYRCMVEVCTRPATTATD 85 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQAT 131 Q + +++ QAA + GT V D RY+R FG L+ Sbjct: 86 VRAQLALLREAAAQAARASDCLLVASGTAVVPPDAPIPVTDTPRYRRMARQFGALVDGNL 145 Query: 132 --VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 V G HVHVG A A++L + + ++P AL+ SP+ G DT FAS R F + Sbjct: 146 GIVCGCHVHVGAADRAQALFLANHVRPWLPALQALAVNSPFAGGVDTGFASWRCVEFGRW 205 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P P P + + +E L + ++ + ++W RPS H TVE RV DT L Sbjct: 206 PTAEPSPLLDSAS-YEESASALVDSGILMDRRMIYWFARPSEHHPTVEFRVADTNADLDT 264 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLL--YKFNRFQACRYGLEGVITDPHTGDRRPL 307 V +A L++ LL + + D + + A +YG G+ DP TG+R P Sbjct: 265 TVLVALLLRGLCATLLAQAEERRPPPDAPVPRLRDAHRYAAQYGPTGLALDPFTGERVPA 324 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG--SLIGLVKKH 365 L+ AP G + + L ++ A R + G L +V Sbjct: 325 RSLITALVAAAAPGLRAAGDEAEVHRLLGALLRKGTGAARQRAALHRSGGRGLRAVVDHL 384 Query: 366 CEIW 369 ++ Sbjct: 385 ADLT 388 >UniRef50_B1M5M5 Glutamate--cysteine ligase GCS2 n=15 Tax=Alphaproteobacteria RepID=B1M5M5_METRJ Length = 388 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 72/371 (19%), Positives = 130/371 (35%), Gaps = 12/371 (3%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 + GIE E + + + A + + + +E+A+ D+ Sbjct: 4 AYRFGIEEEFFLADARTRGTPRAGLRAFHAAVRGRLDDA-EREQLQCQVEVASPPTADLA 62 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQA 130 +A + ++ + + + + GTHP +W+ Q D RY + + L ++ Sbjct: 63 EARAHLADLRASLAEIGGERGILTFAAGTHPTARWRDQRPTDKARYHGIMADLRMLGRRN 122 Query: 131 TVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 V G HVHV I L++ L ++P +ALS SP+ QG T A R ++ P Sbjct: 123 LVCGLHVHVEVPDPAARIGLINRLLPYLPVLLALSTGSPFWQGQQTGLAGYRMRAYAELP 182 Query: 191 DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHA 250 G ++ + ++ + I L W +R S + T+E+R+ D+ L A Sbjct: 183 RTGVPELFADADDYARYVDVMTRSGAIADASYLWWHVRASVKYPTLELRIADSCARLDDA 242 Query: 251 VNMAGLIQAT--AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + +A L + N ++A G+ + D P+ Sbjct: 243 LCIAALFRCLVRRVVRDRRLNAGLTAASRGFVLENLWRAECDGVRATLIDEARVRAVPVA 302 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV--------ADGGSLIG 360 LL IA A +G +A R V A + +L Sbjct: 303 AAVEALLADIAEDADALGCGAACAHASRIVAE-GTSADRQMAVFAAARRSGARERAALSA 361 Query: 361 LVKKHCEIWAG 371 +V A Sbjct: 362 VVDHLAAETAA 372 >UniRef50_B2GH73 Putative glutamate--cysteine ligase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GH73_KOCRD Length = 378 Score = 280 bits (716), Expect = 7e-74, Method: Composition-based stats. Identities = 85/367 (23%), Positives = 140/367 (38%), Gaps = 4/367 (1%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLS-QDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 S T GIE E +++ + V + G + +E + + Sbjct: 12 GGSTMSTFGIEEEFLLIDRGDRLPARPTPEQSAQLVSLEAGGGSATPEWLACQVEETSPI 71 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 D A + + A +++ G P + + ++ NERYQR Sbjct: 72 FHDAAGAVDSLVTFRTALHDATDAMGMDVVGLAAAPDIRPEPADITVNERYQRLAGYTPA 131 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + + G HVH+G +DA+ L+GL ++P +A+ A SP +G ++ F S R Sbjct: 132 VAADQYISGMHVHLGFPDMEDAVRALNGLRGWLPALVAIGANSPLWRGAESGFESWRSIH 191 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 + + N P + E LS +++S L W R S GT+E+R D L Sbjct: 192 YRRWIANDIPPHFKDLADHEQRVAVLSAFDVMESPSTLSWLARLSHKHGTLEIRACDVQL 251 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 +V +A LI+A A + + P E +QA R+GL G + DP + Sbjct: 252 EAQDSVAIAVLIRALADYAMDVPPTM--EFSQEYLDIALWQAARWGLSGRVLDPVAAELV 309 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKH 365 P LLE++ EA R++ N A R A G + G++ Sbjct: 310 PGEALVTDLLERVRDYYPTAADREFAEAGVRRIAERGNGAIRQRRAFARAG-IPGVMDMA 368 Query: 366 CEIWAGD 372 D Sbjct: 369 TAAMTAD 375 >UniRef50_C7NRF5 Glutamate--cysteine ligase GCS2 n=2 Tax=Halobacteriaceae RepID=C7NRF5_HALUD Length = 365 Score = 277 bits (710), Expect = 3e-73, Method: Composition-based stats. Identities = 85/345 (24%), Positives = 147/345 (42%), Gaps = 14/345 (4%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 TLGIE E VV+ G +S +++ ++ I + H++ + ++E T V D A Sbjct: 14 TLGIEEEFFVVDEYGRPVSGTDTLVYNSEPPAILENRLDHELFKFVIESQTPVIEDPGDA 73 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATV 132 A SA++ +++ A DH EI G HP +W+ E + RY+ L+ Y + T Sbjct: 74 AATLSAVRGALVEHARDHGFEIAAAGLHPGARWRELEHAEKPRYRSQLDRIQYPQHRNTT 133 Query: 133 FGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN 192 G HVHVG + A+++ + + +P +AL+A SPY G DT +S+R +F P+ Sbjct: 134 AGLHVHVGVDDAEKAVWIANKIRWHLPIVLALAANSPYWNGFDTGLSSARAKLFEGLPNT 193 Query: 193 GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 G +++ F + + T I +L +D+RP +GTVEVR D + + Sbjct: 194 GMPTTFDSFESFHRFEQRMIETDSISDRGELWFDVRPHTEYGTVEVRTADAQADIDRVLA 253 Query: 253 MAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 + + L E L N+++A R+G E + L Sbjct: 254 LVEYVHELVLDLAARYEDGETITAVRRELLDENKWRAIRHGREASFITRDGAETIDLMTA 313 Query: 311 TLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 R ++ ++ +V+ + A R D Sbjct: 314 IER--DRSRLDLDRL----------ASLVAAESGATRQRRLAEDS 346 >UniRef50_B5GGR3 Carboxylate-amine ligase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GGR3_9ACTO Length = 377 Score = 272 bits (697), Expect = 1e-71, Method: Composition-based stats. Identities = 89/322 (27%), Positives = 139/322 (43%), Gaps = 7/322 (2%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVK---HDITESMLELAT 63 P TLG+E E +V+ + ++D G V ++ SM+E + Sbjct: 43 DPGAPPTLGVEEEFLLVDAETLLPVDAAERVLDVHHRLHPQGAVTAPQRELLSSMIETTS 102 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 VC D+ + SA ++ +++AA + GT Q R + Y+ + Sbjct: 103 PVCADLPGLRAEVSAARERLVEAAGKAGCRVLAHGTAGRQAPPRTP-TEAPHYRDVAGLY 161 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 L + G HVHVG + A++ L L ++P +ALSA SPY G DT FAS R Sbjct: 162 QLLARGTETCGCHVHVGVPDREAAVHALDHLRPWLPVLLALSANSPYEHGADTGFASWRT 221 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSI-KDLHWDIRPSPHFGTVEVRVMD 242 + S +P P+ ++ ++A R L T ++ ++ +W RPS H T+EVRV D Sbjct: 222 MVLSRWPTTQIPPFFADAADYDATHRRLFATGVLPERARNAYWLARPSAHVPTLEVRVAD 281 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITDPH 300 T+ + AGL +A L ER + + A RYGL G + P Sbjct: 282 VMPTVREVASQAGLTRALVVTALRERAAGRVPAPVPAHDVAAALWTAARYGLGGSLVHPL 341 Query: 301 TGDRRPLTEDTLRLLEKIAPSA 322 +G P E LL + P+ Sbjct: 342 SGVAVPAREAPAALLVDLGPAL 363 >UniRef50_Q0RKL9 Carboxylate-amine ligase FRAAL3294 n=2 Tax=Frankineae RepID=CAAL2_FRAAA Length = 383 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 77/373 (20%), Positives = 146/373 (39%), Gaps = 17/373 (4%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKH-------------DITESM 58 T+G+E E +V+P + + +S ++ G ++T Sbjct: 7 RTVGVEEEFVLVDPDRHAVRAAASRVLARGDRDGAGGPPGGADPDGDLDGDLDVELTREQ 66 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E + + G +++ +AA + + T R + RY+R Sbjct: 67 VESGSAPHTSLAGLRGSLVGLRRAAARAAEAAGVALAATAT--CPTPTRPTITPKPRYER 124 Query: 119 TLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 FG ++ G HVHV S +A+ L L ++ +A++A SP+ QG D+ + Sbjct: 125 MRGEFGLTAREQLTCGCHVHVAVHSRQEAVGALDRLRPWLSVLVAMTANSPFWQGADSGY 184 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS R ++ +P G + +++ + L T +++D+R S H+ T+E+ Sbjct: 185 ASYRTQVWQRWPTAGATGAFGSPAEYDRVVDLLIRTGAAMDDGMIYFDVRLSHHYPTLEL 244 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTE--RPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 RV D L++ +V +A L +A + L + ++A R+G+ G + Sbjct: 245 RVADVCLSVDDSVLLAALARALVATAARQWAAGEPVPTVRPELLRAAGWRASRHGVSGEL 304 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 D G+ P R +E + P G A+ AL + + A R A G Sbjct: 305 VDLERGELVPARALVDRFVEWVGPELSATGDGDAVAALVDNLFARGTGADRQRAAYARRG 364 Query: 357 SLIGLVKKHCEIW 369 + +V Sbjct: 365 RIDDVVDLVIRET 377 >UniRef50_C7PYE4 Glutamate--cysteine ligase GCS2 n=2 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYE4_CATAD Length = 372 Score = 272 bits (696), Expect = 2e-71, Method: Composition-based stats. Identities = 79/363 (21%), Positives = 140/363 (38%), Gaps = 7/363 (1%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 TLG+E E +V+ + ++ + ++ G + ++ ++ +E T + Sbjct: 12 LTLGLEEEFVLVDGREPVTVPRAEAVLARIGGRL-DGRMHRELFQTQIETNTLPRVTAAE 70 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ-- 129 + + ++AA + G + + V + RY F ++ + Sbjct: 71 LRADLAETRGAAIEAAAGLDTRLVASGAGVLSR-RPLPVTQSPRYLEIARRFPDVLAEFE 129 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + G H+H+G D A+ L L ++P +L+ SP+ G D AS R F + Sbjct: 130 SEPSGCHIHLGTLDRDRAVLLGTRLRPWMPLLQSLAGNSPFAAGRDRGCASWRYFEFQHW 189 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P GP P ++ +E R L + + K ++W RPS + T+E+RV D L+ Sbjct: 190 PSAGPAPSLTG-GGYERAVRRLMESGTVMDRKMIYWFTRPSERWPTLEIRVADVNPDLNV 248 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLLYK--FNRFQACRYGLEGVITDPHTGDRRPL 307 V +A L++ A +L ++ + A R+GL DP +G Sbjct: 249 PVLLALLVRGLAATILAALQADQPVPGTDEHRLIEDHRLAARFGLAAEGLDPVSGTLASA 308 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCE 367 E LLE P G L +V + A R GSL +V + Sbjct: 309 EERAASLLEFSRPGLEPGGDLETAALLLAEVRATGGGAAQQRADFQVRGSLSDVVDGLVK 368 Query: 368 IWA 370 A Sbjct: 369 RTA 371 >UniRef50_D1BT73 Glutamate--cysteine ligase GCS2 n=2 Tax=Actinomycetales RepID=D1BT73_XYLCX Length = 357 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 137/359 (38%), Gaps = 8/359 (2%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E E+ ++ + + +++ G ++++ E LE AT+ R + + A Sbjct: 1 MGVEEELLLLG-HDGSPAPRAQEVLEGA--DAGDGPLENEFMEEQLETATEPARSLTELA 57 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 + +AA + T P RY R FG + Sbjct: 58 DALRTGRAGAREAAARQDALVAALATSPVAFTGT--TVSRLRYLRARSAFGITAWEQLTN 115 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNG 193 G HVHV A + + +L + ++ +ALSA SP+ QG T + S R +++ +P G Sbjct: 116 GCHVHVAVADDAEGVAVLDRIGPWLAPLLALSANSPFWQGGATGYESFRSQVWARWPTAG 175 Query: 194 PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 P + + + L T + +++D R S + TVE+RV D L + AV + Sbjct: 176 PTRVFGSPEAYHEAVAALVATGTVLDEAMVYFDARLSARYPTVELRVADVCLDVDSAVLL 235 Query: 254 AGLIQATAHWL--LTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 L + E + L + ++A GL+G + DP T P + Sbjct: 236 GALARGLVETAARAAEAGEPPPDAPPELLRTAHWRAGHSGLDGDLLDPATWRPAPAHDVV 295 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRD-FVADGGSLIGLVKKHCEIW 369 L+ + + G + L + S N A R A G L + + + Sbjct: 296 GALVTHVKDALADAGDLDVVTELLGALWSRGNGAVRQRTWAAAADGDLHAVSLQAADAL 354 >UniRef50_UPI0001C31B6A glutamate--cysteine ligase GCS2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31B6A Length = 378 Score = 264 bits (676), Expect = 3e-69, Method: Composition-based stats. Identities = 93/366 (25%), Positives = 162/366 (44%), Gaps = 10/366 (2%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F + T+G+E E+ +++P L+ + L+ + K ++ + +E++T Sbjct: 19 FDATGGLTVGVEEELMLLDPATLALAPMAGELLQRLGGDT---RFKPELPAAQVEISTAA 75 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGY 125 + A Q +A ++ + AA + G HPF + RY +G Sbjct: 76 AASVADAVAQLAAARRDLAAAAGGL-VLPAAAGVHPFSG-AEGALNRGGRYDVLQAEYGP 133 Query: 126 LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNI 185 + ++ V G VHV D + + + L ++P AL+A +P+ G D+ AS RP I Sbjct: 134 IARRQLVAGLQVHVAVGGADRTLAVYNALRAYLPELAALAANAPFHCGRDSGLASVRPTI 193 Query: 186 FSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPL 245 P G P + +W QF A R + + + W++RP FGT+E+RV D Sbjct: 194 SEQLPRQGVPPRLESWDQFAAELRWGALAGSVPEPRMWWWELRPHATFGTIELRVPDAQT 253 Query: 246 TLSHAVNMAGLIQATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 ++ A + QA L + + + NR+ A R+GL+G + D TG+ Sbjct: 254 SVGEAAGVIAFAQALVATLAERHDAREALLDAPTWRIEENRWSALRHGLDGTLADLVTGE 313 Query: 304 RRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 R P + L+ +AP A ++G + A+ A +V N A R+ D G + GLV+ Sbjct: 314 RVPTRDRLGELVAAVAPEAERLGCADALTATRAAIV--ANGAVRQREVARDRG-VDGLVR 370 Query: 364 KHCEIW 369 E + Sbjct: 371 WLTERF 376 >UniRef50_Q4K7H5 Carboxylate-amine ligase PFL_4726 n=1 Tax=Pseudomonas fluorescens Pf-5 RepID=CAAL_PSEF5 Length = 387 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 77/375 (20%), Positives = 142/375 (37%), Gaps = 10/375 (2%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 F +P LGIE E + + + + + + +++ + +E+A+ Sbjct: 3 AFDPGQPQHLGIEEEYLLTDLQSRCMVAEPPPEVLRDCREALGQNFAYEMFQGQIEVASP 62 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG 124 V QA ++ + QA H L G+HP W Q +++ F Sbjct: 63 VFDHSAQAGAYLRQVRSALDQALASHGLGFICAGSHPLADWHEQRATPQAHFRQLFNEFA 122 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 +++ + G HVH + D I +++ + + P +ALS +SP+ QG D+ + S R Sbjct: 123 LAARRSVLSGLHVHAQVPAAVDRIAVMNEVLPWTPLLLALSLSSPFWQGHDSGYLSYRQV 182 Query: 185 IFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTP 244 +P G ++ + Q F+ R L + + + W IRP+ + T+E+R+ D Sbjct: 183 ACDEWPRMGIPEYLHDHQAFDDYLRLLRGIGALGAEDNAWWGIRPALRYPTLELRMTDAC 242 Query: 245 LTLSHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTG 302 ++ A +AGL LL ++ + L K NR QA R G +G Sbjct: 243 PRVADAQTLAGLFAVMVRHACLLPAAGSQYTQAQRWLLKENRVQARRRGAQGRYLMSPDQ 302 Query: 303 DRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA-------DG 355 L + + +A +G + RQ++ G A+ A Sbjct: 303 APMNLGQWLELAEQVFGDTAQALGE-EPLFERARQLLRGGCSAERQLSCHAAQPAESDRE 361 Query: 356 GSLIGLVKKHCEIWA 370 +V Sbjct: 362 ARCRAVVDLLLWESR 376 >UniRef50_C7PYG9 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenulispora acidiphila DSM 44928 RepID=C7PYG9_CATAD Length = 373 Score = 252 bits (645), Expect = 1e-65, Method: Composition-based stats. Identities = 82/373 (21%), Positives = 144/373 (38%), Gaps = 7/373 (1%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L D E T+G+E E +V+P + + A + +V ++ + +E Sbjct: 1 MTLKDSRDLELLTVGVEEEFMLVDPVSRFTVPRAPEV-HAFAAERLGEQVARELYATQVE 59 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 + + + ++ + AA + GT + + + ERY+ Sbjct: 60 INSRPAKQAEVLRQDLVEARRALASAAAHFDCMLVASGTAVLTT-KPFPITEGERYEEIA 118 Query: 121 ENFGYLIQ--QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 E + + G HVHVG D+A+ L L ++P L+ SP+ G+ R Sbjct: 119 ERYSAATTDIDSEASGCHVHVGDLECDEALALAGHLRPWLPVLQVLAVNSPFAAGSFRRV 178 Query: 179 ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEV 238 AS R A+P GP P + ++EA + L ++ + ++W RPS H T+E+ Sbjct: 179 ASWRHYQQQAWPITGPTPMM-TALEYEARAQELVDAGVLIDKRMIYWYARPSEHQPTLEI 237 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY--KFNRFQACRYGLEGVI 296 RV D + + +A L +A A LL + + + A G G+ Sbjct: 238 RVADVCADVDITLLVAVLTRALAMVLLADVRADTPAPRTEELEVREHHRGAATLGPAGLW 297 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 T P +G PL+ L+ P+ + + + L R+ AQ R G Sbjct: 298 THPLSGVSMPLSAGVEALVAHARPALEMLDETRLVAQLLRRAYHRGTGAQRQRAAYRRRG 357 Query: 357 SLIGLVKKHCEIW 369 L +V + Sbjct: 358 RLEDVVDELAAQT 370 >UniRef50_B0UDI3 Glutamate--cysteine ligase GCS2 n=2 Tax=Methylobacterium RepID=B0UDI3_METS4 Length = 377 Score = 249 bits (637), Expect = 9e-65, Method: Composition-based stats. Identities = 73/374 (19%), Positives = 138/374 (36%), Gaps = 13/374 (3%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 ++ F L IE ++ + + D ++ V + +HD+ E L +T Sbjct: 1 MAADFALCIEEDVFLNDAQKRDAARARMRDFLGVCRRDF-PAARHDLIEPRLIWSTPPVA 59 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLI 127 D+ +A A++ + A L + GTHP W R D R + + Sbjct: 60 DLAEARRALEALRGGIGALAAARGLTVMAAGTHPIALWSRVRPRDAAARDRVQRDLQMVG 119 Query: 128 QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS 187 + V G + VG G I +++ + F+P +ALS +SP+ Q T R Sbjct: 120 SRTVVCGLSIRVGLPEGVSRIDVMNRIQPFLPLILALSTSSPFWQAQRTGLMGYRLAASR 179 Query: 188 AFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 P +G P+ + L I + + W IRP+ +++R+ D+ L Sbjct: 180 ELPRSGLPPYFRDEDDHARYLAALMRAGAIADLAHVWWVIRPAGEAHALDLRIADSCTRL 239 Query: 248 SHAVNMAGLIQATAHWLLTERP--FKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + +A L + L + + + N ++A R G+ G + +G+ Sbjct: 240 DDTLAIAALTRCLVRRLARDPSLQRDLTGATHAITAENCWRAQRSGIHGSLMT-ESGEAE 298 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD--------GGS 357 P+ R L +A +G ++ ++ L R +V+ A + + Sbjct: 299 PVPALLSRTLALVAEDGAALGCTAELD-LARWIVARGTSADRQLALFTEAQGRGLPVREA 357 Query: 358 LIGLVKKHCEIWAG 371 L +V G Sbjct: 358 LACVVDWLSAETIG 371 >UniRef50_Q02LX5 Carboxylate-amine ligase PA14_36370 n=7 Tax=Pseudomonas aeruginosa RepID=CAAL_PSEAB Length = 404 Score = 248 bits (634), Expect = 2e-64, Method: Composition-based stats. Identities = 79/343 (23%), Positives = 133/343 (38%), Gaps = 5/343 (1%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 GIE E +++ D+ + + A ++ E +E+A+ V + Sbjct: 8 SGLRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTL 67 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 +AA ++ + A D L GTHPF W+R + R E+ G + ++ Sbjct: 68 AEAARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARR 127 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 + V G HVHV D + +L + ++P +ALSA+SP+ G + AS R + + Sbjct: 128 SLVCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEW 187 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 P P + + + L I + W IRPS H T+E+R+ D L+ Sbjct: 188 PRMNIPPALPDEDAYRRHLALLREAGCIREDGQVWWMIRPSSHVPTLELRICDACPRLAD 247 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 A+++AGL +A L P + N +QA RYG G G + Sbjct: 248 ALSLAGLFRALVGEALGAGPRTLPVARDACLEENYWQALRYGCAGRYL--VGGRAVGAGD 305 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + P A + + H + + G A Sbjct: 306 WLEMAWRQCRPQARQGNEWAYE---HARGLLGETSASRQLRRY 345 >UniRef50_D2Q2P1 Glutamate--cysteine ligase GCS2 n=1 Tax=Kribbella flavida DSM 17836 RepID=D2Q2P1_9ACTO Length = 333 Score = 218 bits (555), Expect = 3e-55, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 123/317 (38%), Gaps = 11/317 (3%) Query: 23 VNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKV 82 V+ + ++ + +L + VK ++ LE+AT V RD+ A + +++ Sbjct: 2 VHRESWMPAEAAPVLAS-----LGDPRVKPELPACQLEIATSVHRDVADAVAELRTCREL 56 Query: 83 VLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCA 142 V A L + HP + E + +I + V VH+ Sbjct: 57 VATACAP-DLALVAAPVHPLV-EGPTALSPTEHAAGLSARYRDVISRQLVSSLQVHLAFG 114 Query: 143 SGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQ 202 D + + H L +P AL+A +P+ G D S RP + S P G P +++W Sbjct: 115 DADCTLSVYHALRDLLPELTALAACAPFTAGRDAGLCSVRPVVASQLPRQGVPPIITSWH 174 Query: 203 QFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAH 262 Q+ + + + W++RP +GT+E+RV+D T + +A + A Sbjct: 175 QYAEDLNWAVQGGAVANASEWWWELRPHLRYGTLELRVLDVQATTAQTSAIARFVHALGA 234 Query: 263 WLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAP 320 L NR+ A R G+ G + D TG+ RP L++ P Sbjct: 235 RLADLHHLGRLEPPAPTWRIAENRWSALRDGVRGELLDLRTGEVRPTRRRLHHLIDTTEP 294 Query: 321 SAHKIGASSAIEALHRQ 337 A G+ + A+ Sbjct: 295 YAP--GSLDDVRAMVEH 309 >UniRef50_P74515 Slr0990 protein n=18 Tax=Cyanobacteria RepID=P74515_SYNY3 Length = 389 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 59/381 (15%), Positives = 126/381 (33%), Gaps = 37/381 (9%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G+E+E+ ++ S ++ + + +E T ++ Sbjct: 3 LTKGLEVEIY-TGKKTGEIVGLSDRIVRDLSG------FVREPDSRNVEYTTPPLNSYDR 55 Query: 72 AAGQFSAMQKVVLQAATDHHLE--------ICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 ++ + + + + GGT F + Q Y +E Sbjct: 56 LLCGILQPRRQLRHYLSQLGEDYTLIPGSCLALGGTDTFYRSDPQNP-----YHTYIE-- 108 Query: 124 GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRP 183 Q H+++G ++ I + P ++ALSA+SP++ G T + SSR Sbjct: 109 QTYSTQVVTASIHINIGIPDVEELIRACRLVRMEAPLYLALSASSPFLNGQVTGYHSSRW 168 Query: 184 NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPH-----FGTVEV 238 +F P +P ++ F + +++ L +RP+ +E+ Sbjct: 169 QMFPKTPQE--VPLFTSHGHFVQWTEEQLTLGTMQNVRHLWSAVRPNGDNRPHNLNRLEL 226 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKH-------QEKDYLLYKFNRFQACRYG 291 R+ D + + L++A +L + + L N A Sbjct: 227 RICDLVTNPLSLLAIVALLEARLQQMLADPTLDPLQQSQLTPSELLALADQNEISAAVSS 286 Query: 292 LEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDF 351 L+ + G E L + + A G + + L R+++ N+AQ Sbjct: 287 LDSTLHHWRDGRAIAAREWIEELYQSVQLEAKYQGFACFLPPL-RKILREGNQAQQWLTQ 345 Query: 352 VADGGSLIGLVKKHCEIWAGD 372 G + +V++ + Sbjct: 346 YEQGKTPQTIVQEAILQTEME 366 >UniRef50_Q31KY6 Glutamate--cysteine ligase, putative n=24 Tax=cellular organisms RepID=Q31KY6_SYNE7 Length = 384 Score = 204 bits (520), Expect = 4e-51, Method: Composition-based stats. Identities = 59/375 (15%), Positives = 121/375 (32%), Gaps = 26/375 (6%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 T G E+E+ S L D + + + + +E T ++ Sbjct: 9 LTKGFEVEVY-----TGTPSGQVVGLSDRICSDLQG--FMREPDSRNVEYTTPPRPCYDR 61 Query: 72 AAGQFSAMQKVVLQAATDHH-LEICGGGTHPFQKWQRQEVC-DNERYQRTLENFGYLIQQ 129 ++ + + G T Y +E Sbjct: 62 LLLDLLEPRRRLRAYLQQQGGYTLIPGSTLALSGGDHFYRSDPTNPYHDFIER--SYGTT 119 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 H+++G + + + + P ++ALSA+SP++ G T S+R +F Sbjct: 120 VVTASIHINIGLSDPETILKACRLVRLEAPLYLALSASSPFLDGQVTGSHSTRWQLFPKT 179 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP-----HFGTVEVRVMDTP 244 P +P + F + +++ L +RP+ +E+R+ D Sbjct: 180 PPE--VPLFESHAHFIRWTEAQLAAGSMQNVRHLWSSVRPNGDRRPYKINRLELRICDLV 237 Query: 245 LTLSHAVNMAGLIQATAHWLLTE-------RPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 + + L++A LL + ++ L N A R+ L+ + Sbjct: 238 ANPLDLLAITALLEARLQQLLEQPQLDPLIASRLTPDELVQLSDANEVAAARHSLDADLQ 297 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGS 357 G + L E + P A G S + + ++++ N AQ VA G + Sbjct: 298 HWQDGRTIAARDWIETLYETVFPLAKTRGYSCFLLPI-QRLLQDGNLAQQWLRQVAAGAT 356 Query: 358 LIGLVKKHCEIWAGD 372 ++ + A + Sbjct: 357 PEAVMVQAIAAMAAE 371 >UniRef50_B7K137 Glutamate/cysteine ligase n=9 Tax=Cyanobacteria RepID=B7K137_CYAP8 Length = 380 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 54/377 (14%), Positives = 131/377 (34%), Gaps = 27/377 (7%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 + G+E+E+ + S ++ ++ + +E T + Sbjct: 2 RLSKGLEIEIY-TGTADGQIIGLSDRIVKDLEG------FVREPDARNVEYTTAPLCCYD 54 Query: 71 QAAGQFSAMQKVVLQAATDHH-LEICGGGTHPFQKWQRQEVC-DNERYQRTLENFGYLIQ 128 + + + Q T+ + G T R + Y +E Sbjct: 55 RLLCAILRPRHDLRQYLTNIGNYTLIPGSTLSLGNSDRFYRSDPHNPYHSYIE--QTYGT 112 Query: 129 QATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA 188 H+++G + + + + P ++ALSA+SP++ G T + S+R ++F Sbjct: 113 NVVTASIHINIGISDPEILMQACRLVRLEAPLYLALSASSPFLDGQVTGYHSTRWHLFPQ 172 Query: 189 FPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPH-----FGTVEVRVMDT 243 PD+ +P ++ F + +++ L +RP+ +E+R+ D Sbjct: 173 TPDH--VPLFTSHAHFIQWTEEQLALKTMQNVRHLWTSVRPNGDNRPYNVNRLELRICDL 230 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKH-------QEKDYLLYKFNRFQACRYGLEGVI 296 + +++ L++A L+ + E+ + N + L+ + Sbjct: 231 VVEPIALLSIVALLEARLSQLINDLSLDPLTQSQLSPEELLKITAQNERAVAKDSLKAQL 290 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 G + + L + + +A + G S + L ++++ N AQ G Sbjct: 291 NHWQDGREIWVQDWIEELYQDVWLTAKQGGFSCFLSPL-KKLLREGNLAQQWLRKYESGQ 349 Query: 357 SLIGL-VKKHCEIWAGD 372 + + V + + + Sbjct: 350 DIPSILVDEIEAMTQRE 366 >UniRef50_Q2BQQ6 Putative uncharacterized protein n=1 Tax=Neptuniibacter caesariensis RepID=Q2BQQ6_9GAMM Length = 498 Score = 201 bits (511), Expect = 4e-50, Method: Composition-based stats. Identities = 62/461 (13%), Positives = 126/461 (27%), Gaps = 97/461 (21%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + PDF + ++G ELE+ +V+ L+ L + + ++ ++ LE Sbjct: 33 LDRPDFGKGDT-SIGAELELYLVDKQARPLA-----LNREIIERSGHPQLALELNRFNLE 86 Query: 61 LATDVCRDIN----QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR---QEVCDN 113 + Q G+ ++ + G P K Q + D Sbjct: 87 YNLKPVKAAGKPFSQLEGEMLDAIALINKHIEAEQGVALPVGILPTLKRSDFGLQAMTDE 146 Query: 114 ERYQRTLENFGYLIQQATV----------------------FGQHVHVGCASGDDAIYLL 151 R+ + L + +H D + Sbjct: 147 SRFFALTQALQRLRGRMFCINIDGDPPISLRSKDVTLEGANSSMQIHYRV-EPDQFASMF 205 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA----------------------- 188 + L P +ALSA SP+M G + +R +F Sbjct: 206 NALQLVTPVILALSANSPFMLGHK-LWHETRIPLFRQTIDGRSHEECSRGVPSRVDFGSG 264 Query: 189 FPDNGPMPWVSNWQQFEAL---------FRCLSYTTMID-------SIKDLHWDIRPSPH 232 + G + + + I + R Sbjct: 265 WVREGAYELFAEMVHLHEPIIPVVDSENVQSIIKQGGIPSLEELRMHSGTVWPWNRAVYD 324 Query: 233 -----FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQA 287 +E+R + + T S A + A L + + N +QA Sbjct: 325 QNNGGHLRIEMRSLPSGPTPSDMAANAAFVLGAARGLQALMDEIIPSMPFSVLVNNFYQA 384 Query: 288 CRYGLEGVITD--PHTGDR--RPLTEDTLRLLEKIAPSAHKI-----GASSAIEALHRQV 338 G++ + P G P+ E +L + ++ + + + ++ Sbjct: 385 AEKGMQAELMWITPDAGGLKKVPVMEIARQLWPHVQKGLDQLCVDKDEQTHYLSIMDERL 444 Query: 339 VSGLNEAQLMRDFVADGGS-------LIGLVKKHCEIWAGD 372 +G+N A R L G+V+ + + A + Sbjct: 445 KTGINGAVWQRREFMRLARKMNSAKALTGMVQNYMQYSAAN 485 >UniRef50_P46309 Glutamate--cysteine ligase, chloroplastic n=133 Tax=cellular organisms RepID=GSH1_ARATH Length = 522 Score = 201 bits (511), Expect = 4e-50, Method: Composition-based stats. Identities = 56/434 (12%), Positives = 114/434 (26%), Gaps = 91/434 (20%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLS--QDSSMLIDAVKNKI----------------TAG 48 + + +G E E + L++ + + Sbjct: 103 KTKDKYRIGTEHEKFGFEVNTLRPMKYDQIAELLNGIAERFEWEKVMEGDKIIGLKQGKQ 162 Query: 49 EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 + + EL+ ++Q + ++ V A + + G G P + + Sbjct: 163 SISLE-PGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEEMGIGFLGIGFQPKWRREDI 221 Query: 109 EVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 + RY G L V++ +S D I P A Sbjct: 222 PIMPKGRYDIMRNYMPKVGTLGLDMMLRTCTVQVNLDFSSEADMIRKFRAGLALQPIATA 281 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTM---- 216 L A SP+ +G F S R +I++ G + FE M Sbjct: 282 LFANSPFTEGKPNGFLSMRSHIWTDTDKDRTGMLPFVFDDSFGFEQYVDYALDVPMYFAY 341 Query: 217 -----IDSIKDLH--------------------WDIRPSPHFGTV------EVRVMDTPL 245 ID W+ + F V E+R D Sbjct: 342 RKNKYIDCTGMTFRQFLAGKLPCLPGELPSYNDWENHLTTIFPEVRLKRYLEMRGADGGP 401 Query: 246 TLSHAVNMAGLIQATAH-----WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + + + + + + + N+ P Sbjct: 402 -WRRLCALPAFWVGLLYDDDSLQAILDLTADWTPAEREMLR-NK-------------VPV 446 Query: 301 TGDRRPLTE-----DTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGLNEAQLMRDFVA 353 TG + P + +L+ + G + + A+ V +G+ A+ + + Sbjct: 447 TGLKTPFRDGLLKHVAEDVLKLAKDGLERRGYKEAGFLNAVDEVVRTGVTPAEKLLEMYN 506 Query: 354 D--GGSLIGLVKKH 365 G S+ + ++ Sbjct: 507 GEWGQSVDPVFEEL 520 >UniRef50_A0YFA7 Putative uncharacterized protein n=2 Tax=unclassified Gammaproteobacteria RepID=A0YFA7_9GAMM Length = 493 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 65/430 (15%), Positives = 129/430 (30%), Gaps = 88/430 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P F ++G ELE+ +V + + +ID +K+ ++ ++ LE Sbjct: 33 LADPAFGTGN-SSIGAELELYIVGTD-GNPLYANQEIIDELKD----PQLTVELNRYNLE 86 Query: 61 LATDVCRDINQA----AGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDN 113 R A + + V AA + I G P + V + Sbjct: 87 YNLTPYRLARSAFSSIEEEIVKKLREVNAAAAIYDGRIVAIGILPTLKRSDFGDHSVTER 146 Query: 114 ERYQRTLEN----------------------FGYLIQQATVFGQHVHVGCASGDDAIYLL 151 +RYQ + + + VH D A + Sbjct: 147 KRYQALMSQLIKRSGTQFRIDVNGEDPLKLTMEDITFEGANTSFQVHYRVNPIDFA-DIY 205 Query: 152 HGLSRFVPHFIALSAASPYMQGT---------------DTRFASS-------RPNIFSAF 189 + + P +A+ A SP + G DTR + R N + Sbjct: 206 NAIQVVTPLAVAIGANSPTLFGHSLWHETRVPLFKQSIDTRHTDAYRWRNPARVNFGQGW 265 Query: 190 PDNGPMPWV-SNWQQFEALFR--------CLSYTTMID-------SIKDLHWDIRPSPH- 232 + + + + AL + + + RP Sbjct: 266 LRHNAVDLFRETVRIYPALLPICAQHSSKQQQEDGEVPSLAELRLHLSTVWLWNRPVYDD 325 Query: 233 ----FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC 288 +E+R + T V A + A + + + L ++N ++A Sbjct: 326 AEGGHLRIEMRALPAGPTAVDMVANAAFLIGLAEGIRPQINELLPALPFHLAEYNFYRAA 385 Query: 289 RYGLEGVITDPHTG----DRRPLTEDTLRLLEKIAPSAHKIG-----ASSAIEALHRQVV 339 ++GL+ + PH G + +T+ +LL IG + + + R+++ Sbjct: 386 QHGLDAKLVWPHLGQHGYREQTITDIIDQLLPCAQQGLDAIGVPLEESKRYLSVIQRRLI 445 Query: 340 SGLNEAQLMR 349 N A + Sbjct: 446 RKQNGAIWQQ 455 >UniRef50_Q2JXJ9 Glutamate-cysteine ligase, family 2 n=7 Tax=Bacteria RepID=Q2JXJ9_SYNJA Length = 489 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 77/443 (17%), Positives = 126/443 (28%), Gaps = 87/443 (19%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 F P G ELE +V P D + +S ++AV + V ++ +EL + Sbjct: 44 RPFAQGSPVG-GFELEAWLVTPQ-GDPAPINSAYLEAVND----PLVVPELARFNIELNS 97 Query: 64 DV----CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDNERY 116 + Q + + A + G P + Q+ + +RY Sbjct: 98 RPQVLVASALQQLRQELEQRWDRCCRVAEQLQAGLMTIGILPTLQQQQLTLEMISPRKRY 157 Query: 117 QRTLENFGYLIQQ------------------------------ATVFGQHVHVGCASGDD 146 E L ++ A +H+ A Sbjct: 158 LALNEQILNLHRREQPSRIPPLGLTIEGPATLLRVTHPNVMLEAATTSFQIHLQVA-PHQ 216 Query: 147 AIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSN------ 200 A + +AL+A SPY+ G D +A +R +F +GP P Sbjct: 217 AARYFNASLLVSAPLVALAANSPYLFGHD-LWAETRIPVFEQ-ALDGPPPLAPTHQPRVT 274 Query: 201 --------------WQQFEALFRCLSYT---------TMIDSIKDLHWDIRP-----SPH 232 W+ L T + + RP Sbjct: 275 FGQGYVQESLMELFWENLRCYPVVLPQTLAASPWELAHLRLHNGTIWRWNRPLVGVDPYP 334 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 +E RV TL + A L QE + + N + A R+GL Sbjct: 335 HLRIEQRVAAAGPTLPDMIANAAFYFGLVQALGARPLPPEQELSFAQCRANFYAAARFGL 394 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKI-----GASSAIEALHRQVVSGLNEAQL 347 E IT + L+ + ++ + L +V SG N A Sbjct: 395 EAPITWLNGWQGSLRQLLLQELIPQAEAGLAQLDLAPQDIQEYLGILRARVESGQNGATW 454 Query: 348 MRDFVADGGSLIGLVKKHCEIWA 370 R +VA G + + C W Sbjct: 455 QRRYVARHG--KDMQQLTCAYWE 475 >UniRef50_Q6Z3A3 Glutamate--cysteine ligase B, chloroplastic n=81 Tax=cellular organisms RepID=GSH1B_ORYSJ Length = 496 Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats. Identities = 50/433 (11%), Positives = 111/433 (25%), Gaps = 89/433 (20%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLS--QDSSMLIDAVKNKITAGEVKHD----------- 53 E + +G E E +++ + + ++ + Sbjct: 77 KPKENWRIGTEHEKFGFEVDTLRPIKYDQIRDILNGLAERFDWDKIVEENNVIGLKQGKQ 136 Query: 54 ----ITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 EL+ ++Q + ++ V + + G G P Sbjct: 137 SISLEPGGQFELSGAPLETLHQTCAEVNSHLYQVKAVGEEMGIGFLGIGFQPKWALSDIP 196 Query: 110 VCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 + RY+ G L V++ +S D I P A+ Sbjct: 197 IMPKGRYEIMRNYMPKVGSLGLDMMFRTCTVQVNLDFSSEQDMIRKFRTGLALQPIATAI 256 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFP--DNG-PMPWVSNWQQFEALFRCLSYTTM----- 216 A SP+ +G + S R +I++ +G + FE M Sbjct: 257 FANSPFKEGKPNGYLSLRSHIWTDTDNNRSGMLPFVFDDSFGFERYVDYALDVPMYFVYR 316 Query: 217 ----IDSIKDLH--------------------WDIRPSPHFGTV------EVRVMDTPLT 246 ID W+ + F V E+R D Sbjct: 317 NKKYIDCTGMSFRDFMVGKLPQAPGELPTLNDWENHLTTIFPEVRLKRYLEMRGADGGP- 375 Query: 247 LSHAVNMAGLIQATAH-----WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHT 301 + + +++ ++ + + P T Sbjct: 376 WRRLCALPAFWVGLLYDEESLQSISDMTSDWTNEEREMLRR--------------KVPVT 421 Query: 302 GDRRP-----LTEDTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGLNEAQLMRDFVAD 354 G + P + + +L+ + G + + + SG+ A+ + + Sbjct: 422 GLKTPFRDGYVRDLAEEILQLSKNGLERRGYKEVGFLREVDAVISSGVTPAERLLNLYET 481 Query: 355 G--GSLIGLVKKH 365 S+ + ++ Sbjct: 482 KWQRSVDPVFQEL 494 >UniRef50_B5JFC0 Glutamate-cysteine ligase family 2 n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFC0_9BACT Length = 417 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 64/389 (16%), Positives = 131/389 (33%), Gaps = 34/389 (8%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNK------ITAGEVKHDITESMLELAT-DVC 66 GIELE +V+ + ++ + + + +V +++ +LE T Sbjct: 12 FGIELEYMIVDRDTLRPRPIAESILLDENGETTQEISLGSIDVSNELATHVLEFKTAGPT 71 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC----DNERYQRTLEN 122 D+ Q F+A + H+ + G HPF + D Y Sbjct: 72 ADLEQLERDFAAAITEMNDRLAVHNAMLAPTGIHPFMDPAIESTTWSKGDRTIYDAYDRI 131 Query: 123 FGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 FG + H+++ A+ ++ L + +P+ ALSA+SP+++G F + Sbjct: 132 FGCSSHGWFNLQSCHINLPFANEEEFARLHTAIILILPYLPALSASSPFIEGEYRGFLDT 191 Query: 182 RPNIFSA----FPD-NG--PMPWVSNWQQFE-ALFRCLSYTTMIDSIKDL----HWDIRP 229 R +++ P+ G + + ++ + + + R Sbjct: 192 RLDVYKNNQAKVPEIAGDIVPEAIFTYADYQSQILEKTYAAIKPYDPDGILQYEWLNSRG 251 Query: 230 S---PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT---ERPFKHQEKDYLLYKFN 283 + +E+RV+DT + +A LI A L + E+ + + Sbjct: 252 AIARFDRNAIEIRVLDTQENPKQDIGIASLIIALLEKLCSLNIEKLKQLALSHTSKQRKA 311 Query: 284 RFQA-CRYGLEGVITD---PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 +F A + G E ++ +T P L KI + + ++ Sbjct: 312 QFLAVAKDGFEADLSVRDLANTFGLNPNETTVGELWAKIVEALKDHPRVAKRTTALGYIL 371 Query: 340 SGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 + A+ M V L E+ Sbjct: 372 QEGSLAERMIARVGTKPDQEDLKSTLAEL 400 >UniRef50_B8KSF5 Glutamate-cysteine ligase, family 2 n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KSF5_9GAMM Length = 504 Score = 191 bits (486), Expect = 3e-47, Method: Composition-based stats. Identities = 69/462 (14%), Positives = 137/462 (29%), Gaps = 100/462 (21%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P+F V P ++G ELE+ +++ + S + L++A + ++ ++ + LE Sbjct: 40 LAQPEFGVG-PQSIGAELELYIIDAE-GNPSHINQRLLEAAAD----PQLTLELNKYNLE 93 Query: 61 LATDVC----RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDN 113 + + + A I G P + Sbjct: 94 YNLTPHLLAESAFRATEQEMLKKVHQLDRCAAAADARIVPIGILPTLTMDDLTEACITPK 153 Query: 114 ERYQRTLENFGYL----------------------IQQATVFGQHVHVGCASGDDAIYLL 151 ERY L L + VH A D A Sbjct: 154 ERYYALLGELVRLRGGQFEIDIDGAEPLKMKVDNITLEGANTSFQVHQRVAPEDYANR-F 212 Query: 152 HGLSRFVPHFIALSAASP---------------YMQGTDTRFAS-------SRPNIFSAF 189 + + P +A+ A SP + Q DTR +R + + Sbjct: 213 NAIQLATPLALAIGANSPGLFGHQLWDETRIPLFKQSIDTRHVDPYGWHEPARVSFGHGW 272 Query: 190 PDNGPMPWVSNWQQFEALFRCLS--------YTTMID---------SIKDLHWDIRP--- 229 P +Q L+ L + + + RP Sbjct: 273 CRGDPHELF---EQMVRLYSPLLPVCEPSSERAGAAEAPELAELRLHLSTVWLWNRPVYD 329 Query: 230 --SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQA 287 + +E+R M T V A + + L E + ++N ++A Sbjct: 330 HVAGGHLRIEMRAMPAGPTAIDMVAGAAFLIGVSTSLADEMESLLPAIPFHYAEYNFYRA 389 Query: 288 CRYGLEGVITDPHTG----DRRPLTEDTLRLLEKIAPSAHKIGAS-----SAIEALHRQV 338 +YGL + P G + + + +LL +G S + + R++ Sbjct: 390 AQYGLSSRLVWPRRGQYGLEEASVVDVIAQLLPSADDGLAALGVSQSERDRYLGVIERRL 449 Query: 339 VSGLNEAQLMR--------DFVADGGSLIGLVKKHCEIWAGD 372 + +N A R + +L +++++ E+ A + Sbjct: 450 AARMNGADWQRQCLGQLMGKRYSKTRALKSMLERYRELSASN 491 >UniRef50_A4RZD5 Gamma-glutamate cysteine synthase n=2 Tax=Viridiplantae RepID=A4RZD5_OSTLU Length = 484 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 62/430 (14%), Positives = 113/430 (26%), Gaps = 87/430 (20%) Query: 7 HVSEPFTLGIELEMQ---------------------VVNPPGYDLSQDSSMLIDAVKNKI 45 E F +G E E +V G+ ++ +I K+K Sbjct: 57 KPREAFRIGTEHEKFGYDEATKRRMDYPVVRHVLSSLVERHGWTPINEADNIIGCTKDKQ 116 Query: 46 TAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW 105 V + EL+ ++ Q + + V A + G G P Sbjct: 117 ---SVTLE-PGGQFELSGAPLENLTQTDEEVRWHIETVNALAREKGHRFLGIGFDPKWSV 172 Query: 106 QRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPH 160 + RY+ G V++ S D + P Sbjct: 173 AEVPMMPKGRYKIMRAYMPKKGTRGHDMMFRTCTIQVNLDFESEQDMVRKFRTSLALQPL 232 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTM- 216 A+ A S ++ G DT + S R +++ G + FE + M Sbjct: 233 ATAMFANSAFVDGADTGYQSMRSDVWRDTDDDRTGTLAWVFDDDFGFEKYCDYVMNVPMY 292 Query: 217 --------IDSIKDLH--------------------WDIRPSPHFGTV------EVRVMD 242 +D + W+ + F V E+R D Sbjct: 293 FVYRNGTYVDVSGESWLDFMEGKLPQLPGDKPTIDDWEQHLTTVFPEVRLKKYMEMRGAD 352 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACR-----YGLEGVIT 297 + + + L L +++ E + A R GL Sbjct: 353 GG-SYEAIMALPALWVGL---LYSDKALDAAEAMVSDWTQVERDALRVDVTKDGLSAKF- 407 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHK--IGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + +++E + +G + L V G + A M + A Sbjct: 408 -----RGGTANDIAKKMVELSVQGLQERGLGEEVYLRYLQDIVDDGKSVAARMSEMNARE 462 Query: 356 --GSLIGLVK 363 G L + + Sbjct: 463 WNGDLEKVYE 472 >UniRef50_A9TJF8 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9TJF8_PHYPA Length = 502 Score = 187 bits (476), Expect = 5e-46, Method: Composition-based stats. Identities = 55/429 (12%), Positives = 117/429 (27%), Gaps = 79/429 (18%) Query: 7 HVSEPFTLGIELE---MQVVNPPGYDLSQDSSMLIDAVKNKITAGEV-KHD--------- 53 + +G E E Q+ + S L+D + ++ V + + Sbjct: 81 KPKSEWRIGTEHEKLGFQL-DTLKRMTFDQISKLLDGMASRFGYERVMEGENIIGLSKDG 139 Query: 54 -----ITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 EL+ +D++ + + V + L G G P + Sbjct: 140 ASVSLEPGGQFELSGAPLKDVHACQRELDTHLEQVNIIGKELGLRFAGIGYEPKWPLSER 199 Query: 109 EVCDNERYQRTLENFGYLI-------QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHF 161 RYQ + F ++ V++ S D I L P Sbjct: 200 PNVPKARYQVIKDYFPKIVITEVGFETMYQTCTAQVNLDFDSEQDMINKLRVGLSLQPLA 259 Query: 162 IALSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTM-- 216 AL A SP+ +G + + R ++S F G + FE M Sbjct: 260 TALFANSPFWEGKPAGYKTYRSFLWSQFDDDRTGELPFVFDDDFGFEKYTEYALNVPMLM 319 Query: 217 ------------------------------------IDSIKDLHWDIRPSPHFGTVEVRV 240 ++ + ++ ++R + +E+R Sbjct: 320 VHRNDNWRDVSGASFKNFMAGKLEAYPGEKPSLNDWMNHLGTMYPEVRLKKY---LEMRG 376 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 D + + + + +D+ + +G++T Sbjct: 377 ADCCPK-DFLNALPAFWVGLLYDEQSLKNCLDIIRDWSNDDRGFLR-KEVPNQGILTPFR 434 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGLNEAQLMRDFVAD--GG 356 G L + +L+ + G + L +G+ A+ M + G Sbjct: 435 EG---TLQDVAKDVLKLAKDGLARRGLQEGKFLAPLEEVATTGVTLAERMLKLYEEEWDG 491 Query: 357 SLIGLVKKH 365 + + + Sbjct: 492 RVDPIFNEL 500 >UniRef50_C6MEH3 Putative uncharacterized protein n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MEH3_9PROT Length = 474 Score = 185 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 58/427 (13%), Positives = 113/427 (26%), Gaps = 76/427 (17%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA- 73 G ELE +++ Y S + + + N V +++ EL Sbjct: 46 GYELEFWLID-HNYFPSPINQAFLTRLNN----PLVVPELSCFNAELNGVPLPLRGDVLT 100 Query: 74 ---GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLE------ 121 + + +AA + G P + + + D RY+ E Sbjct: 101 AISQELNQNWLQCQEAAHGMDSVLMMIGILPTVRQKDLCLSNMSDLRRYRALNEQVVMQR 160 Query: 122 -----------------NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 ++ +A +H+ A D A+ + +A Sbjct: 161 VGRPLHIRIKGRENLDIYHPDVMMEAAATSFQIHLQSAQRD-AVRYFNASIIAAGPILAA 219 Query: 165 SAASPYMQGTD-------------------TRFASSRPNIFSAFPDNGPMPWVS-NWQQF 204 + SP++ TD + R + + + N Sbjct: 220 AGNSPFLFDTDLWDETRVPLFEQSVEIVDEANLENHRVSFGQGYARESLFECFAHNIATH 279 Query: 205 EALFRCLSYT------TMIDSIKDLHWDIRPSPHFGT-------VEVRVMDTPLTLSHAV 251 L L T + + IRP F +E RV+ + T+ + Sbjct: 280 PVLLPMLMDTPTQQFEHLRLHNGTIWRWIRPLIGFDHDGTPHLRIEQRVLPSGPTIVDMM 339 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT 311 A L +L + + N + A R GL + + T Sbjct: 340 ANAALYFGLVRFLADLGDAPESRLSFEQARNNFYAAAREGLRARMVWWNDNVTDAKTLFI 399 Query: 312 LRLLEKIAPSAHKI-----GASSAIEALHRQVVSGLNEAQLMRDFVADGGS--LIGLVKK 364 +L + + + +V SG A R + + L + Sbjct: 400 EEILPMARQGLKDLKIDKADIDHYLGVIEMRVQSGQTGAVWQRAYREKHQADNLQLVAAY 459 Query: 365 HCEIWAG 371 + +G Sbjct: 460 LEKQRSG 466 >UniRef50_Q2SQ10 Uncharacterized conserved protein n=2 Tax=Gammaproteobacteria RepID=Q2SQ10_HAHCH Length = 490 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 59/444 (13%), Positives = 118/444 (26%), Gaps = 88/444 (19%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 PDF V + G ELE+ +++ G S + ++ AV + + ++ LE Sbjct: 36 PDFGVGPA-SFGAELELYIIDKQGR-PSAKNQEILAAVND----PNLTLELNRFNLEYNL 89 Query: 64 DVCR----DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERY 116 + + Q ++ + + A H + G P K + + D+ RY Sbjct: 90 EPTPASGASFSALQRQIDSVLRTLQGHAASHEASLLPIGILPTLKSEDMGPDAITDSPRY 149 Query: 117 QRTLENF----------------------GYLIQQATVFGQHVHVGCASGDDAIYLLHGL 154 Q + + H + D + Sbjct: 150 QALARQLREKRGEDFHISIKGRDTLDLYWQDVSLEGANTSFQFHYRV-NPADFADAFNAA 208 Query: 155 SRFVPHFIALSAASPYMQGTDTRFAS----------------------SRPNIFSAFPDN 192 P +AL+A SP G + +R + + Sbjct: 209 QLVTPLAVALAANSPLFLGRRLWHETRVALFKQATDYRIETPLRLRLPARVLFGNGWVRK 268 Query: 193 GPMPWV-SNWQQFEALFRCLSYTTMID------------SIKDLHWDIRP---SPHFGTV 236 FE L + + RP G + Sbjct: 269 DAHEVFCEGVSLFEPLLPICGDGAALRPGQAPPLDELRLHQGSIWAWNRPIYDPADGGHI 328 Query: 237 --EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 E+R + + + + A L L + ++N ++A +YGL Sbjct: 329 RIEIRALPAGPSTTDMLANAALTVGLIEGLRPAMHDMLPAIPFRYCEYNFYRAAKYGLRA 388 Query: 295 VITDPHTG----DRRPLTEDTLRLLEKIAPSAHKI-----GASSAIEALHRQVVSGLNEA 345 + P G RP+ + +L H + ++ + +N A Sbjct: 389 KLFWPGQGGAGLQERPVLDILEDMLPVAEQGLHALAIAPTDVRHYLDVCAENLAQPVNGA 448 Query: 346 QLMRDFVAD---GGSLIGLVKKHC 366 + S +++ Sbjct: 449 LWQLRMLERLRPHRSDEEALRELV 472 >UniRef50_Q39ZU6 Gamma-glutamylcysteine synthetase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q39ZU6_PELCD Length = 462 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 74/440 (16%), Positives = 128/440 (29%), Gaps = 86/440 (19%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLS--QDSSMLIDAVKNKIT------------- 46 L + + + +G+E+E VV+ + L+ +++ Sbjct: 23 QLRNIRPRDQWGVGVEVEKLVVDRQTGQAAEFSRIEALLSHLESAGGWQGQREAGRLIAL 82 Query: 47 ---AGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ 103 + V + LEL+ +C D+ S + + AA L G G HP Sbjct: 83 MGESSSVTLE-PGGQLELSGKLCTDLCCCQRDLSRHVRRIDSAARPLGLAFLGLGVHPIT 141 Query: 104 KWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFV 158 Q + RY E G L Q G V++ D + + Sbjct: 142 PLQDIDWLPKPRYAIMREYMLRTGDLGQHMMKLSAGLQVNLDFCDEADCMDKIRTGQLLA 201 Query: 159 PHFIALSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTT 215 P F AL A SP M G + F S+R I++ +G + + Sbjct: 202 PLFYALFANSPLMNGKPSGFLSTRGEIWARTDPDRSGIILELFRPGAGLSSYVDYALDVP 261 Query: 216 M--IDSIKDL--------------------------HWDIRPSPHFGT------VEVRVM 241 M I L WD+ S F +E+R Sbjct: 262 MYFILRQGHLIDLTRRRFSFRRYLSEGFEDFRPTLADWDLHLSTLFPEVRLRPQIELRSA 321 Query: 242 DTPLTLSHAVNMAGLIQAT-----AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 D+ A+ +A L + A + + + + + N + R GL Sbjct: 322 DSLP-PHLAMAVAALAKGLMYDDEARYQVAKLLDPGDDAQRMEVYRNSW---RLGLR--- 374 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEAQLM 348 L E LL ++G + ++ + SG+ A+ + Sbjct: 375 ---TPCGNHTLREVACELLAVAREVLRRVGPRDCPCGSEARFLDGIEEVAHSGVTLAERL 431 Query: 349 RDFV--ADGGSLIGLVKKHC 366 A L L+ Sbjct: 432 LQDWQGAPEQRLAALLTHCA 451 >UniRef50_C8NRE4 Family 2 glutamate-cysteine ligase n=11 Tax=Actinomycetales RepID=C8NRE4_COREF Length = 495 Score = 180 bits (457), Expect = 7e-44, Method: Composition-based stats. Identities = 58/423 (13%), Positives = 112/423 (26%), Gaps = 92/423 (21%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV----CRD 68 ++G+ELE+ +V+ + + +L + GE + +I +EL Sbjct: 43 SIGLELELNLVDADMQPALRGAEVL------RHLDGEFQSEIGNYNVELNHPPLSAKHDG 96 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW----QRQEVCDNERYQRTLE--- 121 + + + V +AAT + + GT P + RY+ Sbjct: 97 LQRLQDGITNRLNRVHEAATTEGVNVAMIGTLPTITPEFLADPAWMTQENRYRALSNAVM 156 Query: 122 -------------------NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 +F + ++T +H+ A + + Sbjct: 157 ESRGELVHINLADREHVNQSFHDIAPESTCTSMQLHLQLA-PTRFAAAWNASQAIAGAQV 215 Query: 163 ALSAASPYMQGTDTRFAS--------------------SRPNIF--SAFPDNGPMPWVSN 200 ALSA SP G S RP ++ + + Sbjct: 216 ALSANSPLFLGRRVWHESRIPVFKQAIDTRTSELVNQGVRPRVWFGERWITS----VFDL 271 Query: 201 WQQFEALFRCLSYTTMID------------------SIKDLHWDIRPSPHFG------TV 236 +++ F L + RP G + Sbjct: 272 FEENVRYFSPLIAEDRALAGTPMMKGKSPALHYLNLHNGTIWRWNRPIYAPGEERSHLRL 331 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 E R++ T + V A +L+ E + + N R GL + Sbjct: 332 ENRLLPAGPTPADIVADAAFYYGVVKYLVEENRPVWSRLTFADAERNFQSGARSGLFARM 391 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQLMRDF 351 T P G LL + ++ A + + + + N A Sbjct: 392 TWPRLGQVNATDLIVEHLLPQAREGLRRLEVDDSIAEHYLGIIDERARTRQNGATWQLRT 451 Query: 352 VAD 354 + Sbjct: 452 LNK 454 >UniRef50_B1KDI6 CBS domain containing protein n=1 Tax=Shewanella woodyi ATCC 51908 RepID=B1KDI6_SHEWM Length = 636 Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats. Identities = 58/435 (13%), Positives = 121/435 (27%), Gaps = 90/435 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M + + +G E E +V+ D + + L++++ + +++ LE Sbjct: 32 MLKKEMFEKDISRIGAEQEFFLVD-EHMDPAPLAMTLLESMND----PCFTNELALFNLE 86 Query: 61 LATDVCRDINQA----AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 D A Q + K +L+ + E+ G P +++ + Sbjct: 87 ANLDPHEFTKDAISKTEQQLQELYKKLLKHIAAENGEVITTGILPTIRYRDLTLDNLTPQ 146 Query: 114 ERYQRTLENFGY----------------------LIQQATVFGQHVHVGCASGDDAIYLL 151 RY + G ++ +A VH + D A + Sbjct: 147 PRYFALNDTLGQQRGEDCKLYIRGQDELSFSHDNVLIEACNTSFQVHFQVSQQDFA-HYY 205 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA----------------------- 188 + +A++A SP + G + +R +F Sbjct: 206 NISQAITAPLLAIAANSPLLLGKR-LWHETRIALFQQAIDTRQSNLNLRESEPRVWFGSQ 264 Query: 189 FPDNGPMPWV-SNWQQFEALFRCLSYTTMI---------------DSIKDLHWDIRP--- 229 + + + + +F+ L T + ++ RP Sbjct: 265 WVKSSVLELFQEDISKFKVLISNDIETDSMAQLKQGQVPKLDALCMHNGTVYRWNRPCYG 324 Query: 230 ----SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF 285 PH +E RV+ + T+ A+ + + + D+ K N Sbjct: 325 VQNNVPHL-RIENRVLPSGPTIVDAIANMAFFLGLMNGYGSRLDDVTKIMDFSAAKKNFD 383 Query: 286 QACRYGLEGVITDPHTGDRRPLTEDTLR-LLEKIAPSA-----HKIGASSAIEALHRQVV 339 L I G+ P E R L+ + I + ++V Sbjct: 384 NVSMRSLNTDIVWF-NGEVIPCAELIERELIPVAREGLALANIDQTDIDKYIGIIEQRVA 442 Query: 340 SGLNEAQLMRDFVAD 354 N + M Sbjct: 443 KRTNGSIWMLRNFEK 457 >UniRef50_B0S3P4 Glutamate-cysteine ligase n=2 Tax=Finegoldia magna RepID=B0S3P4_FINM2 Length = 434 Score = 179 bits (454), Expect = 2e-43, Method: Composition-based stats. Identities = 57/414 (13%), Positives = 121/414 (29%), Gaps = 71/414 (17%) Query: 10 EPFTLGIELEMQVVNPPGYDLS-----QDSSMLIDAVKNKITAGEVKHDI---------- 54 E FT+G+E+E +V+ + + N A + D Sbjct: 22 EDFTIGMEMEHFIVDKDTLKTVSYFGDNGVGATLRELHNHGCAAYKEGDYILGLENDDLA 81 Query: 55 ----TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 S E+A +I+ + + +++ + + G HP K ++ Sbjct: 82 VSTEPGSQFEVALSSKWNIDDLKDIYIKNMRKLVEIFDKKNQAMVTLGYHPVTKIDEIKI 141 Query: 111 CDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALS 165 +RY + F G + + +S D + + P F L Sbjct: 142 LPKKRYDFMYKYFNERGDMAHNMMKGTCSLQCSIDYSSEKDFVRKYKIANCLSPVFYTLF 201 Query: 166 AASPYMQGTDTRFASSRPNIFS--AFPDNGP--------------------MPWVSNWQQ 203 + +G ++ + R I+ +G P + + + Sbjct: 202 DNAYIFEGEPSKSRNMREIIWENTDTDRSGMYKFSFDDDLSYKKYAEHILNTPLIFSIDE 261 Query: 204 -----------FEALFRCLSYTTMIDS-IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 F+ +F + T +I + + D+R + +E+R+MD + Sbjct: 262 NHEPYYVGKTTFKEVFEDVKDTGLIFHALSIVFPDVRAKRY---IEIRMMDEIKYPLNFS 318 Query: 252 NMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 +A LI+ + L + + Y + A GL+ + E Sbjct: 319 AVA-LIKGLFYDEVNLDKLSELFKNMTYENCMKAKLDAREKGLDATFM------NVNMLE 371 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVK 363 L++ + L + G+N + G +V Sbjct: 372 FCKMLVDMAKNGL-PANEIGYLIPLEEMLEKGMNPRDQFEKIYKEKGLREAVVA 424 >UniRef50_A1ZDC2 CBS domain pair protein n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZDC2_9SPHI Length = 662 Score = 178 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 57/436 (13%), Positives = 120/436 (27%), Gaps = 90/436 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M D+ P +G E E+ +V+ + S ++ A+ +++ +E Sbjct: 32 MLENDWFEQAPIRIGAEQEVCLVD-EHGKPAPKSMEILAALN----HPSFTTELSRFNIE 86 Query: 61 LATDVCRDINQA----AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---CDN 113 + + ++ + A D + G P + ++ Sbjct: 87 ANLSPVEFTGDCFSRVQKELDDLMDLIHKTAHDLEARVILTGILPTIRKFDLDIENLTPI 146 Query: 114 ERYQRT---LENFGYLIQ--------------------QATVFGQHVHVGCASGDDAIYL 150 +RY +E +A VH+ D + Sbjct: 147 DRYYALLQAIERLRGKAAYELKIEGLDELNLKHDSALIEACNTSFQVHLQVT-PQDFVSK 205 Query: 151 LHGLSRFVPHFIALSAASPYMQGT---------------DTR-------FASSRPNIFSA 188 + + +S+ SP + G DTR + S R + Sbjct: 206 YNIAQAISAPVLGVSSNSPMLFGKRLWNETRIALFQQSVDTRITNEHLRYTSPRVTFGNG 265 Query: 189 FPDNGPMPWV-SNWQQFEALFRCLSYTTMID---------------SIKDLHWDIRP--- 229 + N + + +F+ L ++D ++ RP Sbjct: 266 WVKNSILDLYKEDIVRFKVLLTTDVKEDVLDSVKNNKTPQLQALSIHNSTVYRWNRPCYG 325 Query: 230 -----SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR 284 PH +E R++ + T V + + P + ++ K N Sbjct: 326 ISPNGKPHL-RIENRILPSGPTTLDEVANSAFWVGLMNGFEEAYPDVTKVLEFDDVKANF 384 Query: 285 FQACRYGLEGVITDPHTGDRRPLTEDT-LRLLEKIAPSAHKI-----GASSAIEALHRQV 338 + R GL G G E LL K + +E + + Sbjct: 385 IKTARTGL-GSKHHWVHGKTVNDIELIQKELLPIARIGLEKAKVDEKDINKYLEIIEDRT 443 Query: 339 VSGLNEAQLMRDFVAD 354 +G+N ++ + + Sbjct: 444 ETGMNGSRWILKSYSK 459 >UniRef50_Q092K6 Glutamate--cysteine ligase n=2 Tax=Cystobacterineae RepID=Q092K6_STIAU Length = 446 Score = 178 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 63/436 (14%), Positives = 114/436 (26%), Gaps = 82/436 (18%) Query: 1 MPLPDFHVSEPFT----LGIELEMQVVNPPGYDLSQ-----DSSMLIDAVKNKITAGEV- 50 M L F +E LG+E E V G L++ + G Sbjct: 18 MLLEGFRAAEKPRAGHLLGLEHEKFVYPVGGLAPVPYEGPSGIGALLEKIGGAGDYGLFR 77 Query: 51 -KHDIT---------------ESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEI 94 + LEL+ R +A + V AA L++ Sbjct: 78 ETPESPVIALQRGIETVSLEPGGQLELSGSPFRTAREAHAENLRHLAEVKAAAGPLGLQL 137 Query: 95 CGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQ-----QATVFGQHVHVGCASGDDAIY 149 G PF RY+ + V A D + Sbjct: 138 VALGYRPFGTTADMPWMPKTRYKMMRRTLPERGRLALNMMLMTSTGQVSFDWADEADCVR 197 Query: 150 LLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP--DNG-PMPWVSNWQQFEA 206 ++R P +AL A SP + G + + S R ++ G + + A Sbjct: 198 KTVLVARLSPLMVALYANSPILDGKPSGWLSYRSRVWDEVDPTRCGYLPAFFDGSFSYRA 257 Query: 207 LFRCLSYTTMI----------------------------------DSIKDLHWDIRPSPH 232 ++ D + L ++R Sbjct: 258 YVEWALDAPLLFLRRRGQYLYPKLSFRQLLKEGFEGQPPDMGDWTDHLSTLFPEVRLKKV 317 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRY 290 +EVR D + + L + + + E + ++ A + Sbjct: 318 ---IEVRGAD-CASAEMVGALGALWRGLLYDAGAMEEAERLLPKLTLAEHRAFHETARQQ 373 Query: 291 GLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGLNEAQLM 348 GL G + G + L ++ ++ +E L R SG + A + Sbjct: 374 GLAGRL----NGQQ--LHRLAAEMVAMARRGLQRLDPQDVPLLEPLERVAASGRSPAAAV 427 Query: 349 RDFVADGGSLIGLVKK 364 + L+ + Sbjct: 428 LEAWEKDPRPEALLSR 443 >UniRef50_A2BYV9 Uncharacterized conserved protein n=7 Tax=Prochlorococcus marinus RepID=A2BYV9_PROM5 Length = 372 Score = 178 bits (451), Expect = 4e-43, Method: Composition-based stats. Identities = 55/372 (14%), Positives = 127/372 (34%), Gaps = 35/372 (9%) Query: 15 GIELEMQVVNPPGY---DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 G E+E+ + S + N + +E T+ +D Sbjct: 9 GFEVELF-----TGSKNNHIGVSDEIEKTFSN------FVKEPDNRNVEYITNPEKDYKV 57 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNER-YQR-TLENFGYLIQQ 129 + +K + Q ++ L I T F+ + + D Y + +N+G I Sbjct: 58 SYQNLLEPRKHLRQWLSNRDLTIIPSSTLCFKHDSKFQRSDKNNVYHQFIQDNYGISI-- 115 Query: 130 ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF 189 H+++G + D + + ++++SA+SP++ T S R F Sbjct: 116 -ATSSVHINLGIDNLDKLFAAIRLVRCEASLYLSISASSPFLNNKITNNHSQRWIQFPKT 174 Query: 190 PDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRP-----SPHFGTVEVRVMDTP 244 P+ +P+ +N + + + +I+ IRP +E+R+ D Sbjct: 175 PN--KVPFFNNHENYIQWIDENIKKGKMHNIRHFWSSIRPNGPQRPHVLDRLELRICDYV 232 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQ--------EKDYLLYKFNRFQACRYGLEGVI 296 + + + L++ L ++ + N +A + L+ + Sbjct: 233 SDIDLLLAITALLELRVIHLFENMTTLDPLITSQFSMDQLTKICDQNEIKAAQNSLDAEL 292 Query: 297 TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 G + E LL +++ +A K ++ +++ + G + +G Sbjct: 293 IHWRDGKKVICREWIRDLLVELSLTAEKFDMVHLLKPIYKVLDEGNQSMNWI-KQYREGL 351 Query: 357 SLIGLVKKHCEI 368 S+ ++K Sbjct: 352 SIEDIMKYTIRE 363 >UniRef50_C7RFC6 Glutamate--cysteine ligase n=3 Tax=Anaerococcus RepID=C7RFC6_ANAPD Length = 432 Score = 177 bits (450), Expect = 4e-43, Method: Composition-based stats. Identities = 56/400 (14%), Positives = 108/400 (27%), Gaps = 70/400 (17%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSM--LIDAVKNKITAGEVKHDI-------------- 54 F +G E E VV+ + + +++ KH+ Sbjct: 23 DFAIGFESEHFVVDKDSLETVSYYGEDGIAQSMEEIAKDSYEKHEEDGKILGLSKDRFDI 82 Query: 55 ---TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 S E+A + I+ + ++ + G HP K + ++ Sbjct: 83 SVEPASQFEIALKSRKKIDDLYEDYKKAMAEIVPVFEKKGQVLANVGYHPKSKIEDIKII 142 Query: 112 DNERYQRTLENF----GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALS 165 +RY E F G + +S +D S P ++ Sbjct: 143 PKKRYDYMYEYFRINGGAYAHNMMKGTASLQCAIDYSSEEDFRKKYFVASALSPFLYSIF 202 Query: 166 AASPYMQGTDTRFASSRPNIFSAFP--DNGP-MPWVSNWQQFEALFRCLSYTTMI--DSI 220 + +G + R I+ G + +E R + T +I Sbjct: 203 DNAYIFEGEVYGKRNLRQMIWDNCDRQRTGVYPFAFDDDFSYEKYAREILNTDIIFVHED 262 Query: 221 KDLHWDIRPS-------------------------PHFGTVEVRVMDTPLTLSHAVNMAG 255 + H+ R +E+R+ D + +A Sbjct: 263 GEDHYKGRLKFSEVMDKDSSDEMIFHALSIVFPDVRAKKYIEIRMPDEVPYPYNFAALA- 321 Query: 256 LIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLR 313 LI+ + L + DY R ++ RYGL D + + L Sbjct: 322 LIKGLFYDEENLDRLYEIFTDMDYRSLTNFRSRSERYGLHATYKDKE------IYKWALD 375 Query: 314 LLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA 353 +E S + ++ L + + RD Sbjct: 376 FVEMAKRSLE--DEAHYLKPLREILEEEKSP----RDIYE 409 >UniRef50_D0LNP6 CBS domain containing membrane protein n=3 Tax=Myxococcales RepID=D0LNP6_HALO1 Length = 640 Score = 177 bits (450), Expect = 5e-43, Method: Composition-based stats. Identities = 53/437 (12%), Positives = 113/437 (25%), Gaps = 88/437 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M D + +G E EM +V+ + ++ + + + ++ +E Sbjct: 31 MIENDQFETGRRRIGAEQEMFLVDRAMR-PCPAAMEILTGIDD----ERITTELARFNIE 85 Query: 61 --LATDVCRD--INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 + V + Q + + ++V +AA H E+ G P + + + Sbjct: 86 ANINAQVFGGNCLRQMETELGEVVELVRRAAEPHGAEVLLAGILPTLRKTDLGLENMTPS 145 Query: 114 ERYQRTL------------------ENFGYLIQQATVFGQ----HVHVGCASGDDAIYLL 151 RY+ + + + VH + A + Sbjct: 146 PRYESLNRALTQQRGGDFHIHIKGTDELQFTHDNVMLEACNTSFQVHFQVTPEEFA-RMY 204 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS-----------------------A 188 + +A + SP G + +R +F Sbjct: 205 NVAQAVTAPVLAAAVNSPVFLGQR-LWQETRVALFQLSVDERSATHQSRGFPPRVSFGSG 263 Query: 189 FPDNGPMPWVSN---------WQQFEALFRCLSYTTMID-------SIKDLHWDIRP--- 229 + + E + + + R Sbjct: 264 WVRESVLEIFREQIARFRILLAADLEEDSLAMLERGEVPTLRALRVHNGTTYRWNRACYG 323 Query: 230 ---SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ 286 +E RV+ T++ V A L L P + + + N F+ Sbjct: 324 ISEGIAHLRIENRVLPAGPTVADEVANAALYFGLMSAFLEAYPDISKVMAFDDARMNFFE 383 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTL-RLLEKIAPSA-----HKIGASSAIEALHRQVVS 340 A R+GL+ T+ LL I + ++ S Sbjct: 384 AARHGLKAQF-HWVGDKVYSATDLLTSHLLPMARKGLQNADIDSADIDRYIGIMEERIKS 442 Query: 341 GLNEAQLMRDFVADGGS 357 AQ + +++ G+ Sbjct: 443 RRTGAQWVLRSLSEMGA 459 >UniRef50_D0I9T0 Putative uncharacterized protein n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0I9T0_VIBHO Length = 490 Score = 177 bits (450), Expect = 5e-43, Method: Composition-based stats. Identities = 58/431 (13%), Positives = 119/431 (27%), Gaps = 86/431 (19%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P + TLG ELE+ + + + + ++D + + +I + +E Sbjct: 33 LDTPGWGEGA-CTLGAELELYLTDKHHR-PAHCNLDILDKAAD----PLMTPEINQFNVE 86 Query: 61 LA---TDVCRDI-NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF---QKWQRQEVCDN 113 T + + A + + G P + + + + Sbjct: 87 YNCPYTGFHGSPFTFLKRNMDQKLQFLQGIARGDGINVIPIGILPTLRDGDFGPESMTNL 146 Query: 114 ERYQRTLENFG----------------------YLIQQATVFGQHVHVGCASGDDAIYLL 151 RYQ + + + VH D+ Sbjct: 147 PRYQALTDILRESRGGPFHICIHGLENLQIEAEDVTLEGANTSFQVHYRVK-PDEFAQWY 205 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDN----GPMPWVSNWQQFEA- 206 +G+ +A++A SP + +R +F D+ G V + Sbjct: 206 NGIQIATIFTLAIAANSPIFL-QKKLWHETRVPLFKQSIDSRNLCGMSWHVPARVSYGKG 264 Query: 207 LFR----CLSYTTM--------------------------IDSIKDLHWDIRPSPH---- 232 R L + + R Sbjct: 265 YVRKSALELFRQGVSLQPVLLPDLPASTCKEGCGPILGALRLHQSTIWSWNRAVYDDADG 324 Query: 233 -FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYG 291 +E+R + T V A L A+ L + K+N ++A +YG Sbjct: 325 GHLRIELRSLPAGPTTIDMVANAALCIGLAYALQENLDRLLDRLPFEFAKYNFYRAAQYG 384 Query: 292 LEGVITD--PHTGDRR--PLTEDTLRLLEKIAPSAHKIGASS-----AIEALHRQVVSGL 342 + I TG + PL + +LL +A + K+G + + + ++ Sbjct: 385 IHADILWESSETGRLQEYPLVDVLAKLLPGVADALVKLGVARLEADMLMAVIEHRLAKRQ 444 Query: 343 NEAQLMRDFVA 353 + A +A Sbjct: 445 SGAVWQLKTLA 455 >UniRef50_B4S4M7 Putative uncharacterized protein n=7 Tax=Chlorobiaceae RepID=B4S4M7_PROA2 Length = 494 Score = 177 bits (449), Expect = 5e-43, Method: Composition-based stats. Identities = 55/427 (12%), Positives = 121/427 (28%), Gaps = 86/427 (20%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA-- 72 G ELE +V+ + + + ++ V + + V +++ E+ + Sbjct: 60 GFELEGWLVD-SNCNPAASNEEFLEKVNHHL----VVPELSRYNFEINSTPHPPGGAMFR 114 Query: 73 --AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLEN----- 122 + +++ + A ++ G P ++ V +RY Sbjct: 115 LMHEELASIWEHCSAIAATIGVKPMMIGILPTIDNRQLCLDNVSPLQRYSALNREILRSR 174 Query: 123 -------------------FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 ++ +A +H + A+ + +A Sbjct: 175 QKKPLRIHIEGITETLDIVHHDVMAEAATTSLQIHFQTT-PNLAVRHYNAAHLLSAPMVA 233 Query: 164 LSAASPYMQGTDTRFASSRPNIFSA-------FPDNG----------------PMPWV-S 199 +A +PY+ G + ++ +R +F +G + Sbjct: 234 STANAPYLFGKE-LWSETRIPLFEQAVSIPTFTDRHGNIISRVTFGRDYARHSLLEVFLE 292 Query: 200 NWQQFEALFRCLSY------TTMIDSIKDLHWDIRP--------SPHFGTVEVRVMDTPL 245 N F L + + + RP PH +E RV Sbjct: 293 NLDAFPILLPVVFDEDPGWMNHVRLHNGTIWRWNRPLIGMNKEGKPHL-RIEHRVPSAGP 351 Query: 246 TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 ++ + + +LL+E+ + + N +QA RYGL+ G Sbjct: 352 SIPDCIANIAFFYGSMLFLLSEKEPLSTMLSFEDIRHNFYQAARYGLDAR-IRWLNGRTM 410 Query: 306 PLTEDTLRLL------EKIAPSAHKIGASSAIEALHR-QVVSGLNEAQLMRDFVADGG-S 357 + E LL +A ++ + R +V A F+ G Sbjct: 411 SVQELITTLLLPGAYSALLAADVDPDDVRLYLDGIIRPRVTEKKTGAHWQTAFIRRHGPD 470 Query: 358 LIGLVKK 364 + + Sbjct: 471 FQAMTEH 477 >UniRef50_Q5FPI3 Glutamate--cysteine ligase n=1 Tax=Gluconobacter oxydans RepID=Q5FPI3_GLUOX Length = 486 Score = 177 bits (448), Expect = 8e-43, Method: Composition-based stats. Identities = 60/426 (14%), Positives = 104/426 (24%), Gaps = 91/426 (21%) Query: 7 HVSEPFTLGIELEMQVV-------NPPGYDLSQDSSMLIDAVKNKITAGEVKHDI----- 54 + +G E E I A+ K+ + + Sbjct: 55 KPQSEWKIGTEHEKFGFVLPHAAEGREPLSPPPYEPRGIGALLEKLQGPDWAPIMDGENL 114 Query: 55 -----------------TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGG 97 EL+ I + + A V A + L Sbjct: 115 IGLKGQNAQAGRAISLEPAGQFELSGAPVVSIQETEAEMQAHFDQVRGPAAELGLGFLPF 174 Query: 98 GTHPFQKWQRQEVCDNERYQRTLENF---GYLIQQATV--FGQHVHVGCASGDDAIYLLH 152 G P RY G L V++ + D + Sbjct: 175 GFQPLWPRDAMPWMPKSRYAIMRNYMPKVGSLGLDMMTRTCTVQVNLDFSDEADMARKMR 234 Query: 153 GLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMP-WVSNWQQFEALFR 209 P AL A SP+++G S+R I++ +G + + FE Sbjct: 235 VSLALQPVATALFANSPFVEGKANGLLSNRARIWTDTDNQRSGQPSVFFEDGFGFEQYVD 294 Query: 210 CLSYTTMI---------------------------------------DSIKDLHWDIRPS 230 M D + + D+R Sbjct: 295 WALDVPMYFVSRDGKNIDVAGCSFRRWLAGDVQEPLKGLTPTVGDFEDHLTTVFPDVRLK 354 Query: 231 PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC-- 288 +E+R D L V + L + T + ++ + + +A Sbjct: 355 QF---LEMRGADAGK-LEMMVAQSALWVGLLYDPATLEAAEKLVREQPWSVYQQLRAEVP 410 Query: 289 RYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHK--IGASSAIEALHRQVVSGLNEAQ 346 R GL+ G +P R++E + ++ LH G N+AQ Sbjct: 411 RLGLDAAFP----GGLKPF---AKRVVELAEQGLRARVRNEAGYLDPLHLIADGGPNQAQ 463 Query: 347 LMRDFV 352 D Sbjct: 464 YWLDLY 469 >UniRef50_D1R9R1 Putative uncharacterized protein n=1 Tax=Parachlamydia acanthamoebae str. Hall's coccus RepID=D1R9R1_9CHLA Length = 416 Score = 175 bits (444), Expect = 3e-42, Method: Composition-based stats. Identities = 57/414 (13%), Positives = 133/414 (32%), Gaps = 56/414 (13%) Query: 1 MPLPDFHVSEPFT------LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE----- 49 M P S T G+ELE +V+ ++ + L+ + + + Sbjct: 1 MSAPPKEESPRTTWHLFDVFGVELEYMIVDRENLNILPITDQLLYRMLGEYSGDYEKEPI 60 Query: 50 -VKHDITESMLELATD-VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 +++ +LEL T +NQ F K + + + + HP+ R Sbjct: 61 GWSNELALHVLELKTTKPTSKLNQIHADFQREVKDINKYLEAFNGMLMPTAMHPWMDPHR 120 Query: 108 ----QEVCDNERYQRTLENFGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 + E Y F + + H+++ + ++ + L + +P Sbjct: 121 EMKLWTHDNKEIYAAFNRIFNCQGHGWSNLQSNHLNLPFGNEEEFVRLHAAIRMILPLIP 180 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSA----FPD---NGPMPWVSNWQQF-----EALFRC 210 +L+A+SP ++G T F +R N++ + P + ++ + + +++ Sbjct: 181 SLAASSPIVEGKTTGFYDTRLNVYQSNSAKIPSITAHIIPEVCLSFDDYKTKIFDRIYQD 240 Query: 211 LSYTTMIDSIKDLHWDIRPS-PHFGT--VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTE 267 ++ +++ + R + F +E+R++D V ++ I L E Sbjct: 241 IAKFDPKKTLQHEWLNARGAITRFNRNAIEIRLIDVQECPKADVAISRAIAEVIRHLTQE 300 Query: 268 RPFKHQEKDY---LLYKFNRFQACRYGLEGVITD--------PHTGDRRPLTEDTLRLLE 316 R ++ K + G I D E L+E Sbjct: 301 RWLPLEKLHQFHEERLKGILLDGIKNGEYSEIHDAEFLKVFGWTKSSTCTAKELWGHLIE 360 Query: 317 KIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVA---DGGSLIGLVKKHCE 367 ++ G + ++ + + + L + C+ Sbjct: 361 QV-------GYKE--DQALHHILMHGTLSTRILKVLGSNFSHKKLEETYRYLCQ 405 >UniRef50_Q1DCU0 Glutamate-cysteine ligase, family 2 n=2 Tax=Myxococcales RepID=Q1DCU0_MYXXD Length = 496 Score = 173 bits (438), Expect = 1e-41, Method: Composition-based stats. Identities = 64/453 (14%), Positives = 121/453 (26%), Gaps = 90/453 (19%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P F V P T+G ELE+ +V+ G+ L + ++ ++ V ++ LE Sbjct: 33 LARPGFGVGAP-TVGAELELYLVDRLGFPL-PVNRAVLARAED----PRVTLELDAFNLE 86 Query: 61 LATDVCR----DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 + C + + + V +AA+ + G P + + Sbjct: 87 VNLRPCPLAGRSFSALRQEVESAVSAVRRAASMLGARVAVIGILPTLREADLGSGALTSE 146 Query: 114 ERYQRTLENFGY-----------------------LIQQATVFGQHVHVGCASGDDAIYL 150 RY+ + + H+ A GD A + Sbjct: 147 PRYRAMSTAIRQRRSAPFHVSIRGEEEALSLTWKDVTLEGANTSLQYHLRVAPGDFA-RM 205 Query: 151 LHGLSRFVPHFIALSAASPYMQGT----DTRFASSRPNIFSA------------------ 188 + +A + SP G +TR A R + Sbjct: 206 YNAAQLATAPVLAAAGNSPLFLGRKLWDETRVALFRQAVDDRGEPGEGGFQPHARVSFGH 265 Query: 189 -FPDNGPMPWVSNWQQF---------EALFRCLSYTTMIDSI-------KDLHWDIRP-- 229 + G + + R + + + R Sbjct: 266 GWVREGAYELFAEAVALHPPLLPVSGDEPLRERVAAGEVPDLEELRLHQSTVWSWNRAIY 325 Query: 230 ---SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ 286 + +E R + TL + + L ++ N + Sbjct: 326 DPKAGGHLRIEFRALPAGPTLVDMMANGAFLLGLTLALAERVDALLPALPFVHAYGNFIR 385 Query: 287 ACRYGLEGVITDPHTGDRRP----LTEDTLRLLEKIAPSAHKIGASSA-----IEALHRQ 337 A R GL+ + P + P TE RLL + G + + L ++ Sbjct: 386 AARQGLDAELLWPSSTAPSPRPMAATELVKRLLPDAREGLVRAGVDAEEADTLLGILEQR 445 Query: 338 VVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWA 370 VV A R +A S + + Sbjct: 446 VVLRRTGATWQRQMLARLESQMPRRDALAAMLE 478 >UniRef50_D0MH09 CBS domain containing protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MH09_RHOM4 Length = 619 Score = 172 bits (437), Expect = 2e-41, Method: Composition-based stats. Identities = 54/436 (12%), Positives = 109/436 (25%), Gaps = 88/436 (20%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC----RD 68 +G E E+ +V P + + + ++ ++ + ++T LE+ + Sbjct: 40 RIGAEQELFLVEPC-GNPAPVAEQVLKRNRD----PHLVPELTRFNLEINLEPGLLEGDG 94 Query: 69 INQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLE---- 121 + + Q + D +I G P + RY R E Sbjct: 95 LRRLERQLLERLAHARKLTRDLGDDIALCGILPTIHLSDLTLDNMTPRPRYARLNEAITR 154 Query: 122 ------------------NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 ++ + VH+ D + +A Sbjct: 155 LRGGPVQLQITGIDELFVQLDSIMVEGCNASFQVHLQV-DPDAFPRCYNAAQLAAAPVLA 213 Query: 164 LSAASPYMQGTDTRF----------------------ASSRPNIFSAFPDNGPMPWV-SN 200 +P + G S R + + + + + Sbjct: 214 AGVNAPVLFGKRLWHETRIAVFRQAVDTRGGNLYLREMSPRVHFGTDWVRESVLEIYRED 273 Query: 201 WQQFEALFRC---------LSYTTMIDSI-------KDLHWDIRP------SPHFGTVEV 238 +F L + I + ++ R +E Sbjct: 274 LARFRVLLTPESPPEDALNVLEQGGIPRLEALQLFNGTVYRWNRACYGVSEGRPHLRIEN 333 Query: 239 RVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITD 298 RV+ + T + V A L P H+ D+ + N A R GL +T Sbjct: 334 RVLPSGPTPADEVANAAFWAGLVLELAHREPELHRRMDFDEARGNFIAAARLGLGAHLTW 393 Query: 299 PHTGDRRPLTEDTLRLLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQLMRDFVA 353 LL + G + + + +V S A+ +A Sbjct: 394 LDGARWPAQRLILEELLPMARAGLQRAGVDPADIAHYLGLIRERVESRQTGAEWQLRSLA 453 Query: 354 DG---GSLIGLVKKHC 366 GS ++ Sbjct: 454 AMKGQGSRAERLEALV 469 >UniRef50_A3ZWT8 Putative uncharacterized protein n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZWT8_9PLAN Length = 405 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 60/403 (14%), Positives = 135/403 (33%), Gaps = 47/403 (11%) Query: 8 VSEPFTL----GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITES 57 +S+P L G+ELE +V+ D+ + +L++ +I + +++ Sbjct: 1 MSDPLHLFDAYGVELEYMIVDAQSLDVRPIADLLLEKAAGEIISEVELGELAWSNELALH 60 Query: 58 MLELAT-DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN--- 113 ++EL T ++ F + + + HP+ ++ + Sbjct: 61 VIELKTNGPAASLDPLTDYFQQHVTQANEYLSSLGARLLPTAMHPWMDPHTVQLWPHDYN 120 Query: 114 ERYQRTLENFGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 YQ F A + H+++ D+ L + +P AL+A+SP Sbjct: 121 PIYQAYNRIFDCRGHGWANLQSVHLNLPFCGDDEFGRLHAAIRLIMPLLPALAASSPICD 180 Query: 173 GTDTRFASSRPNIF----SAFPD---NGPMPWVSNWQQFEALFRCLSYTTMIDSI--KDL 223 G + F +R ++ P + ++ Y + L Sbjct: 181 GKPSGFLDTRMEVYRTNSQRIPSLTAAIVPEPIYTEGDYQREIFEKMYADIEPHDPEGML 240 Query: 224 ---HWDIRPS---PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQE--- 274 + R + G +E+RV+D + + + + AT L++E+ E Sbjct: 241 QYPFLNARGAIARFDRGAIEIRVLDIQECPAADLAILQAVVATLKALVSEKWTSFAEQQL 300 Query: 275 ----KDYLLYKFNRFQACRYGL-EGVIT--DPHTGDRRPLTEDTLRLLEKIAPSAHKIGA 327 L+ A + +G + ++ +RP + R + ++G Sbjct: 301 VATMPLSQLFLETIRTADTTPITDGDLLRQFGYSARQRPTVAELWRHI------LAELGQ 354 Query: 328 SSAIEALHRQVVSGLNEAQLMR-DFVADGGSLIGLVKKHCEIW 369 + A E+ +++ A+ + D L + + E Sbjct: 355 TPAEESPLDVILTDGPLARRILQKAGHDLSHLQPVYSELAECL 397 >UniRef50_B9ZKM7 Putative uncharacterized protein n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZKM7_9GAMM Length = 478 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 64/428 (14%), Positives = 121/428 (28%), Gaps = 82/428 (19%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC---- 66 P LG E+E + + G L + +++++ + ++ + LEL + V Sbjct: 43 PPRLGFEIEAWLCDAAGRPL-PVNQGVLESM----DSPLATLELAQFNLELNSSVFQVGP 97 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRT---- 119 + + + +AA H E+ GT P + + + RY+ Sbjct: 98 GCFAAILSELNETLRQARRAARHHQAELLMAGTLPTIQPEDLGLHHMSPQARYRALNTAV 157 Query: 120 ---------------LENFGYLIQQATV----FGQHVHVGCASGDDAIYLLHGLSRFVPH 160 E+ + + + VH A + Sbjct: 158 LEQRAQRPLKLDIVGREHLQHAHRDVMLEALATSFQVHTETR-PAVAHRAYNASLVASAP 216 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAFPDNG-----------------------PMPW 197 +A + +P++ G D S R +F + G Sbjct: 217 VLAAAGNTPFVFGHDLWCES-RIPVFEQSVEVGGFADSARGPIRRVTFGTGYLHHSIGEL 275 Query: 198 V-SNWQQFEALFRCLSYT------TMIDSIKDLHWDIRP-------SPHFGTVEVRVMDT 243 N + F L + + RP +E R + Sbjct: 276 FTENLEHFPVLLPARLDAPSRELRHLALHNGTIWRWTRPIVGVDDRGHRNLRLEFRCLPA 335 Query: 244 PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGD 303 TL + L+ P + + N + A RYGL+ + + Sbjct: 336 GPTLIDMLANTAFAMGLTEHLIHGSPDGTLGTPFSEARDNFYNAARYGLDARL-RWGHAE 394 Query: 304 RRPLTEDTLR-LLEKIAPSAHKIGASS-----AIEALHRQVVSGLNEAQLMRDFVADGG- 356 P R LL + A ++G + + + + AQ RD+V G Sbjct: 395 PEPAPRLIRRHLLPRAAAGLERLGVDPAESNSLLGIIAARTATRQTGAQWQRDWVERHGR 454 Query: 357 SLIGLVKK 364 GLV+ Sbjct: 455 DWSGLVRA 462 >UniRef50_B5ZRA7 Glutamate/cysteine ligase n=8 Tax=Rhizobium RepID=B5ZRA7_RHILW Length = 457 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 52/439 (11%), Positives = 106/439 (24%), Gaps = 91/439 (20%) Query: 7 HVSEPFTLGIELE---MQVVN---------------------PPGYDLSQDSSMLIDAVK 42 E F +G E E + G++ D +I + Sbjct: 26 KPRERFRIGTEHEKFAFFRADNSPVPYFGDASISALLTGLQAKSGWEPIMDGGNIIG-LA 84 Query: 43 NKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF 102 + G + + EL+ I++ + + + + A + G G P Sbjct: 85 EQSGMGAISIE-PGGQFELSGAPLETIHETCRESNQHLATLREIAEPMGIRFLGIGGSPK 143 Query: 103 QKWQRQEVCDNERYQRTLENFGYLIQQAT-----VFGQHVHVGCASGDDAIYLLHGLSRF 157 + RY+ + Q V++ +S DD + + Sbjct: 144 WTYAETPQMPKSRYEIMTRYMPKVGSQGLDMMYRTCTIQVNLDFSSEDDMRKKMRVSMKL 203 Query: 158 VPHFIALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPM-PWVSNWQQFEALFRCLSYT 214 AL A+SP+ +G S R +I+ +G + + F Sbjct: 204 QSLATALFASSPFTEGKPNGLLSWRGDIWRDTDNRRSGLLDFTFRDDFGFRDYAEWALDV 263 Query: 215 TM---------------------------------------IDSIKDLHWDIRPSPHFGT 235 M + + L D+R Sbjct: 264 PMYFIVRDGRYHDCTHVTFRQFMNGALKGEIADPAPTMGDWTNHLSTLFPDVRLKRF--- 320 Query: 236 VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGV 295 +E+R D + + KD+ + A R + Sbjct: 321 LEMRGADGGP-WRRICALPAFWVGLLYDDAALDAADQLTKDWSFAEIG---ALRDAVPAQ 376 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEAQL 347 PL + ++ G + + L + A+ Sbjct: 377 GL-KADFRGHPLFDMAREVVGISRAGLKARGKLNREGQDETIFLAPLDEVLAKKATLAED 435 Query: 348 MRDFVADG--GSLIGLVKK 364 + GS+ + + Sbjct: 436 LLSLYHGRWNGSVEPVFED 454 >UniRef50_Q2S261 CBS domain pair protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S261_SALRD Length = 605 Score = 170 bits (431), Expect = 7e-41, Method: Composition-based stats. Identities = 61/429 (14%), Positives = 111/429 (25%), Gaps = 88/429 (20%) Query: 23 VNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFS----A 78 V+ D + +++ + + ++T +E D R Q Sbjct: 2 VD-ERGDPAPVIEEVLERNSD----ERIVTELTRYNVEFNMDPLRFGGDCFQQMEASTSE 56 Query: 79 MQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---CDNERYQRTLE---NFGYLIQQATV 132 + + V EI G P + RY + Q + Sbjct: 57 LVETVRGLTQQVDSEIALTGILPTAHLSDFAMDYMTPRPRYYALNDAISRLRGGAGQYQI 116 Query: 133 FGQ-------------------HVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQG 173 G H S ++ + +A + SP + G Sbjct: 117 RGIDELFVKHDSIMLEGCNTSFQTHFQV-SPEEFPRYYNIAQVVAAPCLAAATNSPLLFG 175 Query: 174 T---------------DTRF-------ASSRPNIFSAFPDNGPMPWV-SNWQQF------ 204 DTR S R + + + D M + +F Sbjct: 176 KRLWRETRIALFQQAVDTRSTNLYLREMSPRVHFGTDWVDESVMEIFKEDISRFRVLLTT 235 Query: 205 ---EALFRCLSYTTMI------DSIKDLHWDIRP-------SPHFGTVEVRVMDTPLTLS 248 E L + ++ R PH +E RV+ + T+ Sbjct: 236 ELGEDSLETLEAGGVPNLKALQLHNGTVYRWNRACYGITDGKPHL-RIENRVLPSGPTVI 294 Query: 249 HAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 + A L E + D+ ++N A R GL T G RP Sbjct: 295 DEIANAVFWYGLVAGLAHEYRDVSEHIDFYEARYNFNAAARSGLASQFT-WLDGSNRPAH 353 Query: 309 EDTLR-LLEKIAPSAHKIGAS-----SAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 E L L+ + + + ++V + AQ D +A + Sbjct: 354 ELILDTLIPLAEEGLRTSDIASSDIDRYLGVIQKRVETQQTGAQWQLDSLARMEEVGSRA 413 Query: 363 KKHCEIWAG 371 ++ + G Sbjct: 414 ERLGALTRG 422 >UniRef50_B9TDX9 Putative uncharacterized protein (Fragment) n=1 Tax=Ricinus communis RepID=B9TDX9_RICCO Length = 529 Score = 170 bits (431), Expect = 7e-41, Method: Composition-based stats. Identities = 61/414 (14%), Positives = 129/414 (31%), Gaps = 58/414 (14%) Query: 2 PLPDFHVSEPFT----LGIELEMQVVNPPGYDLSQDSSMLID---AVKNKITAGEVKHDI 54 P+ + P + GIELE +V+ + + L D ++ + +++ Sbjct: 124 QKPEERMKTPLSAFAGYGIELEYMIVDRETLSIKPIADRLFDDAGSLHQEHDRIGCSNEL 183 Query: 55 TESMLEL-ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW-QRQEVCD 112 +EL D+ F + + A T + + HP+ + Sbjct: 184 VLHQIELKNDHPTADLEALPIWFMEKIQRINSALTVFNARLMPSAMHPWMNPITETRLWP 243 Query: 113 N------ERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 + + Y+R + + A V V++ A + L + +P AL+A Sbjct: 244 HRQAEIYQAYERIFDCHRHGH--ANVQSMQVNLPFADDAEFARLHEAVRWALPLIPALAA 301 Query: 167 ASPYMQGTDTRFASSRPNIF----SAFPDNG---PMPWVSNWQQFE--------ALFRCL 211 +SP+ G + F R ++ P V++ ++ Sbjct: 302 SSPFADGQWSGFMDYRLEVYRTHQQRVPSTAGELIPEPVTSPAEYRSKILVPMFKEIAPY 361 Query: 212 SYTTMIDSIKDLHWDIR---PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTER 268 ++ ++R P +E+R+ D + +A I A L Sbjct: 362 DPEGVLQHE---WLNVRAAVPRFERSAIEIRLADVQECPQADIAIAAAIIALVRHLYDNT 418 Query: 269 PFKHQEKDYLLYKFNRFQACRYGLEGVITDPH-------TGDRRPLTEDTLRLLEK---I 318 L++ + + VITD G+R E L+++ Sbjct: 419 GDWPTADTTNLFRILK-STMLDAEQAVITDSVYLRRLGYAGERCTTRELWQFLIDQPLSS 477 Query: 319 APSAHKIGASSAIEALHRQVVSGLNEAQLMRD---FVADGGSLIGLVKKHCEIW 369 P G + ++ A+ +R+ A+ L ++ C+ Sbjct: 478 LPLLQPWG------PTLQLILKHGTLARRLRNHIGIKAERTKLDATYRELCDCL 525 >UniRef50_C1B0M2 Putative uncharacterized protein n=2 Tax=Rhodococcus RepID=C1B0M2_RHOOB Length = 502 Score = 170 bits (431), Expect = 8e-41, Method: Composition-based stats. Identities = 53/457 (11%), Positives = 124/457 (27%), Gaps = 105/457 (22%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 LG+E+E +V+ + + +++++ + + ++ + +E+ Sbjct: 45 PRPMLGMEIEFNLVHSD-MTPAMSNLAVLESIDDDAV---FQTELGQFNVEMNVRPGPLN 100 Query: 70 NQ----AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ---KWQRQEVCDNERYQRTLEN 122 + A V H ++ G P R+ + N RY++ + Sbjct: 101 GEGTFELERTLRASLHVADARIHGHDAQLVMVGMLPTLELEHLGREWITANPRYEQLNDQ 160 Query: 123 F-----------------------------GYLIQQATVFGQHVHVGCASGDDAIYLLHG 153 ++ +A +H+ A D+ + Sbjct: 161 IFAARGEDIELDLEGVPLEGRAAEKLKVDANSVLPEAACTSLQLHLRVA-PDEFAAHWNA 219 Query: 154 LSRFVPHFIALSAASPYMQGTDTRFAS--------------------SRPNIF--SAFPD 191 +AL+A +P+M G S RP ++ + Sbjct: 220 AQCLAGAQVALAANAPFMAGKALWHESRIPIFAQATDTRPLELKNQGVRPRVWFGERWIT 279 Query: 192 NGPMPWVSNWQQFEALFRCLS------------YTTMID-------SIKDLHWDIRPSPH 232 + +++ F L + ++ RP Sbjct: 280 S----VFDLFEENSRYFPALLPEVSDVDPSAELDAGRVPDLNELQMHNGTIYRWNRPVYD 335 Query: 233 ------FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ 286 +E RV+ T+ + A L+ + + N Sbjct: 336 SDDGKPHLRIENRVLPAGPTVLDTMANAAFYYGALRGLVESDRPIWSRMSFNAAEENLHA 395 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASS-----AIEALHRQVVSG 341 +YG++ + P G RLL G S+ + + + V+ Sbjct: 396 GAKYGMDAELYWPGVGFAGADELVLRRLLPIADEGLAAFGLSAKARDRYLSVIEGRCVTR 455 Query: 342 LNEAQLMRDF--------VADGGSLIGLVKKHCEIWA 370 A R ++ +L +++++ E Sbjct: 456 QTGASWQRAQVVRHENAGLSRREALAAMLRQYVENMR 492 >UniRef50_Q11LE8 Glutamate--cysteine ligase n=22 Tax=Alphaproteobacteria RepID=Q11LE8_MESSB Length = 457 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 57/437 (13%), Positives = 100/437 (22%), Gaps = 93/437 (21%) Query: 12 FTLGIELEMQVVNPPGYDLSQ-----DSSMLIDAVK------------------NKITAG 48 + +G E E G L++ ++ G Sbjct: 31 WRIGTEHEKFPFYVDGNRPVPYEGNRGIRALLEGMQRILGWNPILDDGRIIGLVEPTGQG 90 Query: 49 EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 + + EL+ I+Q + +A + + A + G G P Sbjct: 91 AISLE-PGGQFELSGAPLETIHQTCREGNAHLAQLREIAEPLGIRFLGLGGSPKWTLAET 149 Query: 109 EVCDNERYQRTLENFGYLIQQAT-----VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 RY+ + V++ +S D + R P A Sbjct: 150 PRMPKSRYEIMTNYMPKVGSHGLDMMYRTCTIQVNLDFSSEADMRRKMQIGMRLQPLATA 209 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAFP--DNG-PMPWVSNWQQFEALFRCLSYTTM---- 216 L A SP+ G + S R I+ +G S+ F M Sbjct: 210 LFANSPFTDGAVNGYQSWRGEIWRDTDDQRSGLLPFVFSDQFGFADYVEWALDVPMYFVI 269 Query: 217 -----------------------------------IDSIKDLHWDIRPSPHFGTVEVRVM 241 + + L D+R + +E+R Sbjct: 270 RDGRYHDCTHVTFRQFMSGALRNTVPDGMPTMGDWTNHLSTLFPDVRLKRY---LEMRGA 326 Query: 242 DTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC--RYGLEGVITDP 299 D + + + K + + GL Sbjct: 327 DGGP-WRRICALPAFWVGLLYDDAALDAAEDLTKLWTFEDVQALRDAVPVDGLSATF--- 382 Query: 300 HTGDRRPLTEDTLRLLEKIAPSA--------HKIGASSAIEALHRQVVSGLNEAQLMRDF 351 L E +L + + L V G AQ M Sbjct: 383 ---RNHHLIETAREVLAISRMGLGNRGFKNREGFDETGFLSPLDEVVARGTTSAQEMVTA 439 Query: 352 VAD--GGSLIGLVKKHC 366 GGS+ + +H Sbjct: 440 YHTRWGGSIEPVFLEHA 456 >UniRef50_C4DKI0 Putative uncharacterized protein n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DKI0_9ACTO Length = 456 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 61/446 (13%), Positives = 122/446 (27%), Gaps = 92/446 (20%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKI--TAGEVKHDITESMLELATDVCR----DI 69 +ELE+ +V+ + S + ++ + V+ ++ LEL Sbjct: 1 MELELSLVD-ESGEPSMTNHEVLSHLAENAVANGDSVQDELGRFNLELNLGPRPVAGFGF 59 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---CDNERYQRTLENF--- 123 + + V A H + GT P + + + RY+ + Sbjct: 60 ETYEQRLRLWLQDVNDCARKEHSSVVMVGTLPTVRREHARLDILSRRPRYRLLNDQILSV 119 Query: 124 -------------------GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 + ++ H+ + + +A Sbjct: 120 RGEDISLDISGAETLRAHTDSIAPESVNTSVQFHLQLT-PEQFPRYWNAAQAMAGVQLAT 178 Query: 165 SAASPYMQGTDTRFASSRPNIFSA--------FPDNGPMPWV-----------SNWQQFE 205 +A SPY+ GT +A +R +F G P +++ Sbjct: 179 AANSPYLFGTQ-LWAETRIILFEQATDIRNGELRVQGVRPRAWFGERWITSATDLFEENL 237 Query: 206 ALFRCLS------------YTTMID-------SIKDLHWDIRPSPHFG------TVEVRV 240 F L + I ++ RP G VE RV Sbjct: 238 KYFVPLLPQCVSEDPIEKVNSGEIPQLGELRLHNGTIYRWNRPVYDVGPEGPHLRVENRV 297 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + T L + + + + N A R+G++ T P Sbjct: 298 VPAGPTPIDICANMAFYLGLVTALAEADMPIWTKLPFAVAEQNFHAAARHGIDAHQTWPG 357 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQL-------- 347 G+ LL K A + A + + + +G+N A Sbjct: 358 LGELPARVLVLDHLLPKAAEGLAALDVDSAVAERLLAIIAGRCRNGVNGAAWQVNCVQRL 417 Query: 348 -MRDFVADGGSLIGLVKKHCEIWAGD 372 R ++ +L ++ ++ E A + Sbjct: 418 QQRQGLSRTPALHEMLSRYAEHAATN 443 >UniRef50_D0L3Q4 Glutamate--cysteine ligase, GCS2 n=78 Tax=Actinomycetales RepID=D0L3Q4_GORB4 Length = 502 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 57/425 (13%), Positives = 111/425 (26%), Gaps = 93/425 (21%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 LG+E+E+ +++ + + ++ ++DA+ + + + ++ + +E+ Sbjct: 45 PEPLLGMEVELNLID-DAMNPAMANAAVLDAIAD----PDYQTELGQFNIEINVSPRPFF 99 Query: 70 NQ----AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ---KWQRQEVCDNERYQRTLEN 122 Q A + G P + Q + N RY + Sbjct: 100 ADDTISLEQALRTSLNRAEQRAARTANHLVMVGMLPTLRTEHFAHQWISANPRYDLLNQQ 159 Query: 123 -----------------FGYLIQ-------------QATVFGQHVHVGCASGDDAIYLLH 152 G +A +H+ A +D + Sbjct: 160 IFAARGEDLELDITGIPLGEGATSERLHTSTDSILAEAACTSLQLHLRVA-PEDFAAHWN 218 Query: 153 GLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA--------FPDNGPMPW------- 197 +AL+ SP++ G S R +F + G P Sbjct: 219 AAQAIAGIQVALAGNSPFLAGHALWHES-RIPVFEQATDTRPLELKNQGVRPRVWFGERW 277 Query: 198 ----VSNWQQFEALFRCLS------------YTTMID-------SIKDLHWDIRPS---- 230 +++ F L I ++ RP Sbjct: 278 INTIFDLFEENTRYFPALLPVSSDVDPLEQLDNGEIPTLDELKLHNGTVYRWNRPVYDVV 337 Query: 231 --PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQAC 288 VE RV+ T+ + A L+ + + N Sbjct: 338 DGHAHLRVENRVLPAGPTVVDILANAAFYYGVVRGLVEADRPLWSQMSFNAAAENLQSGA 397 Query: 289 RYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGA-----SSAIEALHRQVVSGLN 343 R GLE I P+ G RP RLL G S + + + ++ Sbjct: 398 RSGLESQIYWPNVGWVRPDELTLRRLLPIADDGLRSFGVSGKARSRYLSVIEGRCINRQT 457 Query: 344 EAQLM 348 + Sbjct: 458 GSVWQ 462 >UniRef50_C8QVM0 Glutamate--cysteine ligase GCS2 n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QVM0_9DELT Length = 415 Score = 166 bits (421), Expect = 1e-39, Method: Composition-based stats. Identities = 60/382 (15%), Positives = 121/382 (31%), Gaps = 45/382 (11%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLI----DAVKNKITAGEV--KHDITESMLELAT-DVCR 67 GIELE +V+ + + L+ AV N++ GE+ +++ + +LEL T Sbjct: 20 GIELEYMIVDHRTLAVRPLADRLLIGPDGAVVNEVDHGELAWSNELVQHVLELKTNGPAE 79 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR----QEVCDNERYQRTLENF 123 + +F + + HP R NE Y+ F Sbjct: 80 SLVGLGARFHRDLVEINGKLAALGAGLLPTAMHPLFDPARETHLWPYGQNEIYEAYDRIF 139 Query: 124 GYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSR 182 G + + H+++ ++ L + +P AL+AASP QG + + +R Sbjct: 140 GCRGHGWSNLQSMHINLPFYDEEEFRRLHAAIRIVLPLIPALAAASPLEQGRRSAWLDNR 199 Query: 183 PNIFSAFPDNGP-------MPWVSNWQQFEA-LFRCLSYTTMIDSIKDL----HWDIRPS 230 + P V+ + + + + ++ + R + Sbjct: 200 LRYYRDNQKAIPEISGLVVPEPVTGIEDYHRQILEPMYAAIRPHDPNEVLSDEWLNSRGA 259 Query: 231 P---HFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQ---EKDYLLYKFNR 284 T+E+RV+D + + +A + L ER Sbjct: 260 IARFERQTIEIRVIDLQECPAADLAIAEAVVELVRALYKERLAGFAAQQALSTEALAEQM 319 Query: 285 FQA------CRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQV 338 ++ G E ++ E +LLE + S + ++ Sbjct: 320 WRCGEQGSQAEIGSEALLALFGCDRPLTAAELWRKLLE------DGLAVSPTAAGMLERI 373 Query: 339 VSGLNEAQLMRDFVADGGSLIG 360 + + A+ V GS+ Sbjct: 374 IVRGSLAE---AIVRRLGSVPS 392 >UniRef50_C6XGY1 Glutamate--cysteine ligase n=2 Tax=Rhizobiaceae RepID=C6XGY1_LIBAP Length = 457 Score = 166 bits (421), Expect = 1e-39, Method: Composition-based stats. Identities = 61/439 (13%), Positives = 125/439 (28%), Gaps = 87/439 (19%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSM-----LIDA------------------VKN 43 E F +G E E + + + ++ A + N Sbjct: 26 KPQEEFRIGTEHESFIFSRADHRPLPYDGEKSIVTILQAIQKKLAWKEIMDKGNIIGLAN 85 Query: 44 KITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ 103 ++ + + LEL+T ++++Q G+ +++ + + L I G G +P Sbjct: 86 PLSKAGISIE-PGGQLELSTTTLQNVHQIKGEILGYIQILKEITQNLDLGILGMGFNPKW 144 Query: 104 KWQRQEVCDNERYQRTLENFGYLIQ---QAT--VFGQHVHVGCASGDDAIYLLHGLSRFV 158 K + RY + + V + +S D L + Sbjct: 145 KLDEMPIMPKSRYVLMKKYMPQVGTHGLDMMFRTCTTQVSLDFSSEHDMATKLRVSFKLQ 204 Query: 159 PHFIALSAASPYMQGTDTRFASSRPNIFSAFP---DNGPMPWVSNWQQFEALFRCLSYTT 215 P A+ A+SP+ +G F S R I+ + + FE + Sbjct: 205 PLATAIFASSPFAEGRINGFQSWRSEIWRHTDSDRTEILPFILRDNSNFEHYAQWALDIP 264 Query: 216 M--IDSIKDLH----------------------------WDIRPSPHFGTV------EVR 239 M I K+ + W+ S F V E+R Sbjct: 265 MYFILRKKEYYCCTDITFRQFMNGALKGRIKEWHPTLEDWENHLSTLFPAVRLRNCLEMR 324 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ--ACRYGLEGVIT 297 D+ L + +A + + H + Y N+ G+ Sbjct: 325 GADSG-RLENIFAVAAFWTGILYDSSALQNADHLTSSWSFYDINKLNNTVPSKGMR---- 379 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKI--------GASSAIEALHRQVVSGLNEAQLMR 349 T + L + +++L + ++ L + + + A M Sbjct: 380 --STVRGQSLKDIAIQILTFAHQGLKNRSAKNHLQEDETIFLKPLEKIIHNNQTTADEML 437 Query: 350 DFVAD--GGSLIGLVKKHC 366 G S+ +++ Sbjct: 438 AAYHTRWGKSIDPCFEEYA 456 >UniRef50_D2AYM1 Glutamate-cysteine ligase, family 2 n=2 Tax=Bacteria RepID=D2AYM1_STRRD Length = 478 Score = 165 bits (419), Expect = 2e-39, Method: Composition-based stats. Identities = 63/443 (14%), Positives = 118/443 (26%), Gaps = 84/443 (18%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P F T+G ELEM ++ P G L + + DA + + ++ LE Sbjct: 33 LARPGFGTGPA-TIGAELEMFLITPDGRPL-PRNHEVRDAADD----DRLVPELGRFNLE 86 Query: 61 LATDVCR----DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ---KWQRQEVCDN 113 + + + +V AA + G P + + + D Sbjct: 87 VNLTPLPIAGRPFSALVRELRETMALVDAAAGTQGGQALAIGILPSLSEFDFTHEALSDE 146 Query: 114 ERYQRTLENFGYLIQQ----------------------ATVFGQHVHVGCASGDDAIYLL 151 RY+ L + + VH+ A D A + Sbjct: 147 SRYRALSRGMRRLRTEPFRVRIEGVEELELEVEGVILESANTSWQVHLRTAPADFA-RVY 205 Query: 152 HGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFS---------AFPD----------- 191 + +A+S SP G + +R +F Sbjct: 206 NAAQLATGPVLAVSGNSPGFLGRR-LWEETRIALFEESADDRDVERLDRRDRRVAFGSGW 264 Query: 192 -NGPMPWVSN-WQQFEALFRCLSY------------TTMIDSIKDLHWDIRP---SPHFG 234 +G + +E + S + + RP G Sbjct: 265 VSGAEEMFETCVRDYEPVLPMTSEQVPAGEGEAPGLAELRLHQGTVWQWNRPIYDPADGG 324 Query: 235 T--VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 VE+R + T + A + + + N ++A +GL Sbjct: 325 HLRVEMRALPAGPTPADMAANAAFLLGLTAAMAAGPVEDFP---FAAAYRNFYRAAIHGL 381 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASS-----AIEALHRQVVSGLNEAQL 347 + + P P + L LL ++G A++ + +V A Sbjct: 382 DAPMAWPGVEGEVPAAQLALDLLPVAKAGLERVGVDPAEADWALDIIRERVRLRRTGAIW 441 Query: 348 MRDFVADGGSLIGLVKKHCEIWA 370 R V G + + Sbjct: 442 QRQVVEGLGGDPAARARMVTRYR 464 >UniRef50_Q4FMS2 Glutamate-cysteine ligase family 2(GCS2) n=2 Tax=Candidatus Pelagibacter ubique RepID=Q4FMS2_PELUB Length = 431 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 60/425 (14%), Positives = 115/425 (27%), Gaps = 79/425 (18%) Query: 7 HVSEPFTLGIELEMQVVNPPG-----YDLSQDSSMLIDAVKNKI------------TAGE 49 + F +GIE E + + Y L+ K Sbjct: 17 KDVKNFKIGIEHEKFLFDEKTNKRVDYPTVLKMFSLLSEFGWKPIMEKENIIGLQKQGKS 76 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + + +EL+ D +I++A + + Q +L+I G P Sbjct: 77 ITLE-PGNQIELSGDKLNNIHEACAESHDYLFELQQVTKKLNLKIVSAGFDPISTLSEVP 135 Query: 110 VCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 +RYQ ++ G L G +++ S D I ++ VP IAL Sbjct: 136 NNPKQRYQVMTKDMPNGGSLSLDMMYRTCGTQLNLDYDSEKDFIKKFKIVNSIVPISIAL 195 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLS------------ 212 A S ++ ++ F+S R ++ G + FE Sbjct: 196 FANSSIIEKKNSGFSSYRSKVWQETSRGGLPEVFFDNMDFEKYADFSINFPLLFIQNEKE 255 Query: 213 --------------------------YTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 + + + + R + +E+R MDT Sbjct: 256 YLSGSNYSFSDFMNGKISEINNRLPTEDDLTTHLSTIFTENRLKKY---IELRSMDTC-G 311 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + + L E + D +A + G + + Sbjct: 312 WDCLCSGPAFNTGILYGNLDEAYELISKWDKNKIINAYLEAPKKGFNTELM------GKD 365 Query: 307 LTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 L + LL + + L + + + A M D + +L Sbjct: 366 LLHWSSLLLGISRKGLLNRDILSKSNDNEAKFLNHLDKLIDNKTTNADHMIDKFSKNENL 425 Query: 359 IGLVK 363 L Sbjct: 426 NDLYD 430 >UniRef50_B6BSN8 Glutamate-cysteine ligase family 2 protein n=2 Tax=root RepID=B6BSN8_9RICK Length = 431 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 54/426 (12%), Positives = 118/426 (27%), Gaps = 79/426 (18%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSS--------------MLIDA---VKNKITAGE 49 ++ F +GIE E + N S +++ + Sbjct: 17 KDTKDFRIGIEHEKFLFNNQDDKRVDYSKIKEMFSSLLEFGWNPILEKGNIIGLNKGGKN 76 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + + +EL+ D +++A + + Q ++I G P K + Sbjct: 77 ITLE-PGNQIELSGDKLITLHEACAESHDYLFELKQVTKKLDIKIVSAGFDPISKLKEIP 135 Query: 110 VCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 +RY+ ++ G L G +++ S +D + ++ VP IAL Sbjct: 136 NNPKQRYELMTKDMPLGGELSLDMMYRTCGTQLNIDYNSEEDFVKKFKIVNSIVPISIAL 195 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLS------------ 212 A S ++ ++ + S R ++ + G FE + Sbjct: 196 FANSSIVEKKNSGYLSYRSKVWQSTSRGGLPKLFFEELNFEKYAEFIINFPILFIQDKDT 255 Query: 213 --------------------------YTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 + + + + + R + +E+R MDT Sbjct: 256 YISGLKYTFKDFMDGKIDEINNRLPNESDLTTHLSTIFTENRLKKY---IELRSMDTC-G 311 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 + L E D +A + G + + Sbjct: 312 WDCLCAGPAFNVGMLYGNLDEVYELISNWDKEKIINAYLEAPKKGFNTQLM------GKD 365 Query: 307 LTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNEAQLMRDFVADGGSL 358 L LL+ + + L + + + A M + ++ L Sbjct: 366 LFYWASTLLDLSRKGLDDRDILNKSGKNETLFLNHLQKLIDNKTTNADHMINKFSNNEDL 425 Query: 359 IGLVKK 364 L + Sbjct: 426 SELYDE 431 >UniRef50_A1WVT1 Glutamate--cysteine ligase, GCS2 n=2 Tax=Ectothiorhodospiraceae RepID=A1WVT1_HALHL Length = 476 Score = 163 bits (412), Expect = 1e-38, Method: Composition-based stats. Identities = 73/418 (17%), Positives = 122/418 (29%), Gaps = 78/418 (18%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR--- 67 P ++G+ELE +V+ G + S ++ V++ V++++ LE+ TDV Sbjct: 42 PPSIGLELEAWLVDADGR-PAPISDRVLSRVED----PRVENELARFNLEINTDVHPLAG 96 Query: 68 -DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDNERYQRTLE-- 121 + + + +AA D + G P + + + RY E Sbjct: 97 TPLQGLQTELAERWARTQRAAADAGCRLALVGILPSVREADVCVENMTPSPRYAALNEQV 156 Query: 122 -----------------NFGYLIQQAT----VFGQHVHVGCASGDDAIYLLHGLSRFVPH 160 F +H+ + Sbjct: 157 LALRGRRPLTLDIEGTQRFRTERHDVMLEAATTSLQLHLQVP-PQRMAAFFNAAVALSAA 215 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPW----------------------- 197 +A++A SP++ G S R +F + Sbjct: 216 SVAVAANSPFLFGRRLWHES-RIPLFEQAVACTRLEPRGAGTLARVGFGSGYARDALYGF 274 Query: 198 -VSNWQQFEALFRCLSYTTM------IDSIKDLHWDIRPSPHFG------TVEVRVMDTP 244 V N Q L L + + RP +E RVM Sbjct: 275 FVENRQHHPVLLPELQDQPVEALAHLRLHNGTIWRWNRPLVEVVDGQCQLRLEHRVMAAG 334 Query: 245 LTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDR 304 TL+ + A L RP +E + + + N + A RYGLE + Sbjct: 335 PTLADVLANAAFFYGAVAELAESRPGLVEELPFHIAEQNFYAAARYGLEAEVEWLDGWFG 394 Query: 305 RPLTEDTLRLLEKIAPSAHKIGASSA-----IEALHRQVVSGLNEAQLMRDFVADGGS 357 R T RLL K + G + A + L +V SG A +V G Sbjct: 395 RLGDLVTERLLPKARRGLVRAGVAEAEATAHLGVLEERVASGRTGAAWQLAWVERHGE 452 >UniRef50_D2L0B8 Glutamate--cysteine ligase GCS2 n=2 Tax=Desulfovibrio RepID=D2L0B8_9DELT Length = 421 Score = 162 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 64/403 (15%), Positives = 131/403 (32%), Gaps = 50/403 (12%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV-------KHDITESMLELA-TDV 65 GIE+E +V+ + + L+ A + A +V +++ +LE+ + Sbjct: 11 FGIEIEYMIVDRETLAVLPVADRLLAAAAGREGAADVDMGKLTWSNELVNHVLEMKVSQP 70 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEVCDNER---YQRTLE 121 ++ A F+A + G HP + +E Y+ Sbjct: 71 APSLSGLAATFAAHVAKADTLLAPFGGRLMPTGAHPLMDPPAETVLWPHEHGEIYRTFDA 130 Query: 122 NFGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFAS 180 F + + HV++ ++ L + +P AL+A++P + G T F Sbjct: 131 IFDCKGHGWSNLQSMHVNLPFRGDEEFGRLHAAIRVLLPIMPALAASTPILDGKFTGFLD 190 Query: 181 SRPNIF----SAFPD---NGPMPWVSNWQQFE--------ALFRCLSYTTMIDSIKDLHW 225 +R + + P V + Q++ + ++ Sbjct: 191 ARMDRYSHNADRVPSVMGAVIPEAVFSEQEYRDRILAPLYRDIAPMDPQGVLQDE---FL 247 Query: 226 DIRPS---PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF 282 + R + T+E+RV+DT + + +AG++ A L+ ER +E+ + Sbjct: 248 NARGAIARFDRSTIEIRVLDTQECPAADLALAGVVVAALKGLVEERWSTFEEQKAWDTRE 307 Query: 283 -NRFQACRYGLEGVITDPHTGDR---------RPLTEDTLRLLEKIAPSAHKIGASSAIE 332 A G P R P RL S + E Sbjct: 308 LADILAMTTKNAGRTPVPPKYARLFGVYAPSNIPARVIWRRL---ALSSLPDMDFDPDWE 364 Query: 333 ALHRQVVSGLNEAQLMRDFVA---DGGSLIGLVKKHCEIWAGD 372 +V + A+ + V ++ + + C+ AG+ Sbjct: 365 KSLAVMVDQSSLARRILAAVDSDYRPRTIRQVYGRLCDCLAGN 407 >UniRef50_C0N7Q3 Putative uncharacterized protein n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N7Q3_9GAMM Length = 475 Score = 161 bits (408), Expect = 4e-38, Method: Composition-based stats. Identities = 58/412 (14%), Positives = 117/412 (28%), Gaps = 77/412 (18%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV----CRDIN 70 G+ELE +++ + + + + + + ++ + +E T+ ++ Sbjct: 46 GLELEAWLID-QTMYPAPINDAFLSILHDPMANA----ELAKFNIEFNTEPLPLTHDCLS 100 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQ---KWQRQEVCDNERYQRTLEN----- 122 + Q Q A E+ G + D RY+ E Sbjct: 101 RLHRQLQNAWSNASQQAQKLDSELLMTGILATLEQHDLNPLNMSDMNRYRALNEQILASR 160 Query: 123 -----------------FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALS 165 ++ ++ +H A + + +A+S Sbjct: 161 GQPVRLDITGEDHLKLSHNDVMLESAATSLQLHTQIP-LTIAHHFYNASIMASAAVVAVS 219 Query: 166 AASPYMQGTDTRFASSRPNIFSAFP--------DNGPMPWVSNWQQFEAL---------- 207 A SP++ G + + +R +F +GP+ VS + Sbjct: 220 ANSPFLFGH-SLWQETRIPLFEQAIESGGFDGASHGPVKRVSFGSDYARHSIFECFQENL 278 Query: 208 --------FRCLSYTTMID----SIKDLHWDIRP----SPHFGTV--EVRVMDTPLTLSH 249 T ++ + RP S V E R T+S Sbjct: 279 DHFPVLLPVDLGEATDALEYLRLHNGTIWRWNRPIVGFSGDKPHVRVEHRTPAAGPTVSD 338 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + A +H + E + + N ++A RYGL+ I D + +R Sbjct: 339 MMANAAFYYGLSHAFCDRLIARGVELSFADARDNFYKAARYGLDAHIVDLNGQHQRIQKY 398 Query: 310 DTLRLLEKIAPSAHKIGASS-----AIEALHRQVVSGLNEAQLMRDFVADGG 356 LL A K+ + + +V + R F+ G Sbjct: 399 ILDELLPLAAQGLDKLNIEDAEKQHYLSIIETRVEKHQTGSDWQRAFINKHG 450 >UniRef50_Q9JMV4 Putative glutathione synthetase GshA (Fragment) n=3 Tax=Bacteria RepID=Q9JMV4_BRAJA Length = 460 Score = 160 bits (405), Expect = 8e-38, Method: Composition-based stats. Identities = 57/388 (14%), Positives = 95/388 (24%), Gaps = 88/388 (22%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQ-----DSSMLIDAVK------------------NKIT 46 F +G E E GY L++ +K + Sbjct: 3 SEFRMGTEHEKTPFTLEGYRPVPYEGARGIGALLEGMKLLLGWEPIMEKGNIIGLYDVTG 62 Query: 47 AGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ 106 G + + EL+ +++Q + A V + A + G G P Sbjct: 63 GGAISLE-PGGQFELSGAPVENVHQTQSELMAHLAQVREIAAPLGIGFLGLGMTPSWSRA 121 Query: 107 RQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHF 161 V RY+ G ++ +S D + L L P Sbjct: 122 DIPVMPKGRYKIMTNYMPKVGQYGLDMMYRTCTVQTNLDFSSEADMVKKLRVLLALQPVA 181 Query: 162 IALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMPW-VSNWQQFEALFRCLSY----- 213 AL A SP+ +G F S R I+ G MPW + FE Sbjct: 182 TALFANSPFTEGKPNGFLSFRSEIWRDTDNARAGMMPWAFEDGMGFERYVDYALDVPMYF 241 Query: 214 ---------------------------------TTMIDSIKDLHWDIRPSPHFGTVEVRV 240 + + + + ++R + +E+R Sbjct: 242 VKRGEDYIDVSGSSFRAFFDGRNNNLPGERPTLSDWANHLSTIFPEVRLKRY---LEMRG 298 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRY-----GLEGV 295 D + L + + + QA R G + Sbjct: 299 SDGGP-WGRLAALPAFWVGL---LYDDVSLDAAWDMVKHWSAHERQALRDDVPRFGFKAR 354 Query: 296 ITDPHTGDRRPLTEDTLRLLEKIAPSAH 323 I D + L E L Sbjct: 355 IKDRY------LFEIAKECLVLAHAGLR 376 >UniRef50_A1K6A6 Glutamate-cysteine ligase n=5 Tax=Proteobacteria RepID=A1K6A6_AZOSB Length = 423 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 56/399 (14%), Positives = 119/399 (29%), Gaps = 48/399 (12%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEV------KHDITESMLEL-ATDVCR 67 G+E+E +V+ D+ + L+ A + A V +++ + E+ Sbjct: 17 GLEIEYMIVDRLHLDVKPIADRLLYAGAGEAVADVVRGEMGWSNELALHVFEIKNRAPSP 76 Query: 68 DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEVCDNER------YQRTL 120 + F + + + GG HP+ + + +R Y R Sbjct: 77 TLAPLVDAFHREVRAAAELLAGMDARLMPGGMHPWMEPSTETRLWTQDRAALYACYDRIF 136 Query: 121 E--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 + G+ Q H+++ + ++ L + +P AL+A+SP+ + Sbjct: 137 DCRRHGWGNLQ----SVHLNLPFSGDEEFGRLHAAVRLALPILPALAASSPWADKRPSGV 192 Query: 179 ASSRPNIFSAFPDNGP-------MPWVSNWQQFEALF-----------RCLSYTTMIDSI 220 +R ++ P ++ + AL + + Sbjct: 193 LDTRLLMYRDHQRLVPASMGDCIPEPIATAADYHALVLAPMYRQVAEYGAVRCKGDASEL 252 Query: 221 KDLHWDIR---PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEK-D 276 + + R P +E+RV+DT V +A L R D Sbjct: 253 RHEWLNARAAVPRFERSAIEIRVLDTQECPLADVAVAAASAGLVRHLYDHRCANADALVD 312 Query: 277 YLLYKFNRFQACRYGLEGVITDPH----TGDRRPLTEDTLRLLEKIAPSAHKIGAS-SAI 331 + + R + I P G L ++ G + + Sbjct: 313 TPVLVDIFERCIRDADQARIEHPDYLALFGLGNGGGLSAGELWGRLLDRLDASGQLPAPL 372 Query: 332 EALHRQVVSGLNEAQLMRDFVADG-GSLIGLVKKHCEIW 369 + + A+ + + D G L + + CE Sbjct: 373 HPPLQLFLQRGPLARRLASALDDDPGRLRAVYGELCECL 411 >UniRef50_C7NI09 Putative uncharacterized protein n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NI09_KYTSD Length = 503 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 57/433 (13%), Positives = 108/433 (24%), Gaps = 98/433 (22%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI-- 69 +G+ELE+ +V+ S + +++ + + ++ +E+ Sbjct: 43 PKIGLELELNLVDEQ-MQPSMSNDDVLEHL-----GDHFQSELARFNIEVNVAPRPAATG 96 Query: 70 --NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE---VCDNERYQRTLE--- 121 + AA + G P + + E + RY + Sbjct: 97 ASPSLEHVVLHHLQEAEDAAQQAACRMVPIGILPTLRPEHLEGEWISGGARYTALEKAIL 156 Query: 122 ----------------------NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVP 159 + A +H S + + Sbjct: 157 HERGGEGASLDIAGPGGERVQMYVPGIAPAAACTSLQLHRQV-SPEKFATFWNAAQLIAA 215 Query: 160 HFIALSAASPYMQGTDTRFASSRPNIFSA--------FPDNGP----------------- 194 +A A SP++ G +A +R +F + G Sbjct: 216 VQVAAGANSPFLFGKR-LWAETRIPLFEQVLDTRTPELRNQGVASRAIFGRDWISSPADL 274 Query: 195 ------------MPWVSNWQQF---------------EALFRCLSYTTMIDSIKDLHWDI 227 L R L + I +D+ Sbjct: 275 FRENIGSYPALLPELFEMPADEGGPKSATPGDRKGRAPELPRLLLHNGTIWRWNRAIYDV 334 Query: 228 RPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQA 287 VE RVM T + + L L+ + P + + N + A Sbjct: 335 VDGVPHLRVENRVMPAGPTAADTLANCALYYGLLRTLVDQSPHPWVGVSHDDAERNFYAA 394 Query: 288 CRYGLEGVITDPHTGDRRPLTEDT-LRLLEKIAPSAHKIGASS-----AIEALHRQVVSG 341 +GL+ + P P+TE LL G S + + R+ +G Sbjct: 395 AEHGLDAELVWPGISGPLPVTELLTEHLLPLAHDGLLAGGTSRQDADTYLGTIRRRCETG 454 Query: 342 LNEAQLMRDFVAD 354 +N A V Sbjct: 455 VNGAVWQTRAVEQ 467 >UniRef50_A4CI62 CBS domain pair protein n=2 Tax=Flavobacteriales RepID=A4CI62_9FLAO Length = 621 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 56/434 (12%), Positives = 119/434 (27%), Gaps = 89/434 (20%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M +G E E +VN ++ S ++ ++ + ++T LE Sbjct: 32 MLEDGLFERNEMHIGAEQEFCLVNAD-WEPSMNAPKILSDLNE----PHFTPELTRYNLE 86 Query: 61 LATDVCR----DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 + D R ++ Q + +AA H +I G P + + Sbjct: 87 INLDPRRLQGTCLSDMHNQLRDLLGRAQEAAARHGDKIILTGVLPTISTRHLGQAYMAPL 146 Query: 114 ERYQRTLE----------------------NFGYLIQQATVFGQHVHVGCASGDDAIYLL 151 RY+ E + ++ + H+ +D Sbjct: 147 NRYRILNEAVKHVRDSDLEMHIKGVDEVNLHHDSIMYEGCNTSFQSHLQI-DPEDFSSAY 205 Query: 152 HGLSRFVPHFIALSAASPYMQGT---------------DTRFASSRPN-------IFSAF 189 + +++ A SP + G DTR ++ R N S + Sbjct: 206 NWAQAIAGPVLSVCANSPLLMGRELWEETRIALFSQSVDTRRSTFRLNEREPRVGFGSEW 265 Query: 190 PDNGPMPWV-SNWQQFEALFRCLSY----------------TTMIDSIKDLHWDIRP--- 229 + + ++ +L T + ++ R Sbjct: 266 ETGSAADFFKRSVARYRSLISTDFEASDSLEQVNRGQAPALTALSLYNGTVYPWNRLCYG 325 Query: 230 ---SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ 286 +E R + + T + + +E ++ D+ K N F Sbjct: 326 RGGKKPHLRIENRYLPSGPTTADEIANLAFWTGIMTGRPSEFDDIRKKMDFRDAKKNFFH 385 Query: 287 ACRYGLEGVITDPHTGDRRPLTEDTLR-LLEKIAPSAHKI-----GASSAIEALHRQVVS 340 A RYG+ G P E L L ++ + ++ + ++ S Sbjct: 386 AARYGMSAQFRW--QGKDVPARELLLDFFLPIAYRGLSRMQVAGADITKYLKLIENRIRS 443 Query: 341 GLNEAQLMRDFVAD 354 + A+ + Sbjct: 444 -QSGAEWKIRTYRE 456 >UniRef50_B7AQN9 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQN9_9BACE Length = 403 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 45/352 (12%), Positives = 112/352 (31%), Gaps = 66/352 (18%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE-------------- 49 F S+ F +GIE+E V + S ++D +K+ + + Sbjct: 36 RGFKRSDDFKIGIEIEHFVFDSNDR--SAGYEKILDVMKDIMGEDDKPYYLEGHLIGFYN 93 Query: 50 ----VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW 105 + + S LE++ C ++ + ++++ + ++L + G +P++ Sbjct: 94 DRYSISLE-PASQLEISIAPCASADELVCIYRDFRRILDPVLSRYNLRVECYGYNPYESA 152 Query: 106 QRQEVCDNERYQRTLENFGYLIQQ---AT--VFGQHVHVGCASGDDAIYLLHGLSRFVPH 160 Q ++ +RY+ F + V V + +DAI + P Sbjct: 153 QELDIIPKKRYEYMDRYFQKAGTRGRNMMRATASVQVSVDYSDENDAIRKYRLAAILSPV 212 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAFPD------NGPMPWVSNWQQFEALF------ 208 + SP + R ++ +G + +++++ Sbjct: 213 LSLMMDNSPVFEKQPAAMHMVRAYVWDGVDADRCVIMDGCLAPDFSFEKYAEYIMNMPAI 272 Query: 209 ----------------------RCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLT 246 R ++ ++ + +D+R +E+R+ D+ Sbjct: 273 LVMEGETAVYTDDKKIKDIYAERVMTDEEVMHVLSMAFFDVRLK---NYIEIRMADSC-N 328 Query: 247 LSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVI 296 + A A +I + + + R ++G +G+I Sbjct: 329 IDKAAWYARIICNIFYNDDNMGKAEEYFAGVGQKDVLEARESLIQHGKDGII 380 >UniRef50_D0LKS0 Glutamate--cysteine ligase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LKS0_HALO1 Length = 451 Score = 158 bits (400), Expect = 3e-37, Method: Composition-based stats. Identities = 51/386 (13%), Positives = 100/386 (25%), Gaps = 53/386 (13%) Query: 26 PGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQ 85 ++ ++ +I +V + LELA + + + Sbjct: 73 QTWEPVRERGNIIALTCADA---QVTIE-PGGQLELAARPVLATADYERDLCSFADDIAE 128 Query: 86 AATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVG 140 + + + G G PF + ERY G L + V++ Sbjct: 129 VSEEFDISWLGLGFRPFGRIDEVGWMPKERYAVMRAYMPTRGALAHEMMKRTATAQVNLD 188 Query: 141 CASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP--DNGP-MPW 197 + +DA + AL A SP + G D+ S R I+ G Sbjct: 189 FSDPEDAGEKMRAAMGAGFLLTALYANSPIVDGADSGHQSYRARIWRDTDPDRCGLLPFV 248 Query: 198 VSNWQQFEALFRCLSY--------TTMIDSIKDLH-----------------WDIRPSPH 232 + F + + W + S Sbjct: 249 FEDGDVFAGYTQWALDVPLFFVYRQGYKPAGGMTFRRFLREGFEGHRATLDDWALHLSTL 308 Query: 233 FGTV------EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN--R 284 F V E+R D+ + + L + + R + + Sbjct: 309 FPEVRMKKYLELRGCDSSAR-DLVIALGPLSRGFLYDREARRATIALTEHLSFAERVTLL 367 Query: 285 FQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--ASSAIEALHRQVVSGL 342 GL + G + + E L+ A + ++ + L +G Sbjct: 368 RDVAERGLAAQVP----GSKASVGEMARSFLDIAADGLARQDPAETAYLAPLREIAETGR 423 Query: 343 NEAQLMRDFVADG-GSLIGLVKKHCE 367 ++A RD G +++ Sbjct: 424 SQADAFRDLWTRTQGDPARIIEALSH 449 >UniRef50_UPI0001AEDC74 hypothetical protein SalbJ_18393 n=1 Tax=Streptomyces albus J1074 RepID=UPI0001AEDC74 Length = 498 Score = 158 bits (399), Expect = 4e-37, Method: Composition-based stats. Identities = 65/433 (15%), Positives = 117/433 (27%), Gaps = 86/433 (19%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 + P F EP TLG ELEM +V + + A + + ++ LE Sbjct: 33 LTSPGFGAGEP-TLGAELEMFLVTRD-GVPVPRNEEIRRAAAD----PRLVLEVNRYNLE 86 Query: 61 LATDVCR----DINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 + + + V +A H E G P + + Sbjct: 87 ANLTPVPLRPRPFTALHDEADTLLEAVRRAGAAHGAEPYCAGLLPTLRPADLTRRNMSPR 146 Query: 114 ERYQRTLENFGYLIQQATVFG-------------------QHVHVGCASGDDAIYLLHGL 154 RY + G + V G +H+ ++ + + Sbjct: 147 GRYAVIDDALGRAGRGLRVSGEQRLRMRSDTFCAQGAASSWQIHLTVR-PEEFTRVHNAA 205 Query: 155 SRFVPHFIALSAASPYMQGTDTRFASS--------------------RPNIFSAFPDNGP 194 +A++A SP + G S R + G Sbjct: 206 QLMTAPVLAVAANSPLLLGRRAWDESRIPWYEQAFGQHRRRVAPADRRSGFGHGWLRGGV 265 Query: 195 MPWVSNW-QQFEALFRCLSYTT---------------MIDSIKDLHWDIRPSPH-----F 233 +++ L S + + L W RP Sbjct: 266 RELAEEAVRRYAPLVPLCSDGDWDRPLRPGGPPALDELRLHLGTLWWWNRPVYDPAGDGH 325 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE 293 +E+R + + T + V L+ L E + L + N + A R G+ Sbjct: 326 LRIELRALPSGPTPADMVANTALLTGLI--LDRAAREPGGELPFALARENFYTAARDGMA 383 Query: 294 GVITDPHTGDRRPLTEDTLRLLEKIAPSAHKI---------GASSAIEALHRQVVSGLNE 344 + P G P+ L+ + P A + + +V++G + Sbjct: 384 ARLWWPA-GPAAPVRLAARDLVRALLPRAAAGLAAAGVADDEVQRWLGVVEARVLTGRSG 442 Query: 345 AQLMRDFVADGGS 357 A R GS Sbjct: 443 AHWQRRTHRALGS 455 >UniRef50_A6GCK2 Glutamate--cysteine ligase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GCK2_9DELT Length = 468 Score = 157 bits (398), Expect = 5e-37, Method: Composition-based stats. Identities = 45/361 (12%), Positives = 86/361 (23%), Gaps = 66/361 (18%) Query: 39 DAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGG 98 + + + + + EL+ ++ +FS + A + G Sbjct: 88 ELIALERDGASITLE-PGGQFELSGAPLPTVHDTCAEFSTHYDELHAVAEPMGVAWIASG 146 Query: 99 THPFQKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHG 153 HPF +V RY G + L Sbjct: 147 FHPFATRGEIDVMPKGRYAVMKSYLPTKGERALDMMFRTCTVQANFDYRDEAQCGLRLRM 206 Query: 154 LSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRC 210 + AL A SPY++G S R + G ++ Sbjct: 207 IMGISGLITALFANSPYVEGEHRGTRSMRSATWEHVDPDRCGLLPFVFEPDFSWQRYVDW 266 Query: 211 LSY------------------------------TTMIDSIKDLHWDIRPSPHFGT----- 235 W++ S F Sbjct: 267 ALDVPMFFVYRGGRYNAHHVPFRRFLAEGYTDEAGTTHRATQADWELHLSTLFPEVRIKP 326 Query: 236 -VEVRVMDTPLTLSHAVNMAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACR-YGL 292 +E+R D+ + + L + E ++ + + ++ R GL Sbjct: 327 FIEIRGADSVGS-KTVCALPALCKGILYDDDAREGAWELVANLDFAGRMDLWKRGRTDGL 385 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG--------ASSAIEALHRQVVSGLNE 344 DP + + +LL ++ + ++AL QV G Sbjct: 386 S----DPE------VLDKCRKLLTLARGGLERLDVRDSKGRTEARFLDALDAQVERGATP 435 Query: 345 A 345 A Sbjct: 436 A 436 >UniRef50_B2HGM5 Putative uncharacterized protein n=3 Tax=Mycobacterium RepID=B2HGM5_MYCMM Length = 499 Score = 157 bits (397), Expect = 6e-37, Method: Composition-based stats. Identities = 60/460 (13%), Positives = 124/460 (26%), Gaps = 99/460 (21%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M + T+G+E+E+ +V+P G ++ DAV + +++H++ + +E Sbjct: 40 MVEAGWFAGHEDTIGMEVELDLVDPLGRP-----RLVNDAVLQALDRTDMQHELGQFNVE 94 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQ----AATDHHLEICGGGTHPFQKWQRQ---EVCDN 113 L + VL + G P + N Sbjct: 95 LNLPPHPLTGHVLRDSEQLLADVLDGSGARIESLGTRLIAVGMLPTLSADHMTAERLSTN 154 Query: 114 ERYQRTLENFG-----------------------YLIQQATVFGQHVHVGCASGDDAIYL 150 RY+ + +A+ +H+ A D Sbjct: 155 PRYELLSRRIRTARHRPFRVHISDAPEPVEFTTDSVAPEASATSLQLHLR-AHRDRFAAY 213 Query: 151 LHGLSRFVPHFIALSAASPYMQGT---------------DTRFAS-------SRPNIFSA 188 + +A++A SP++ G D+R S +R + Sbjct: 214 FNAAQLIAGAQVAVAANSPFLLGRHAWQETRITLVEQLLDSRRPSEVKASAPARVRLGEG 273 Query: 189 FPDNGP----------MPWVSNWQQFEALFRCLSYTTMID-------SIKDLHWDIRPSP 231 + + P + + RP Sbjct: 274 WISDPVDLFDHLVREYPPLFPTLE--AEDPDAALEAGQAPVLHELRLHNGTVWQWNRPVY 331 Query: 232 HFG------TVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF 285 +E RV+ + T V A + ++ + + + + Sbjct: 332 DVQGGSPQLRIENRVLPSGPTAVDMVANAAFYYGLVRAIADSDRTPWEQTPFAVAERDLH 391 Query: 286 QACRYGLEGVITDPHTGDRRPLTEDTLR-LLEKIAPSAHKIGASS-----AIEALHRQVV 339 +A R GL ++ G +P + T LL A G + + + +V Sbjct: 392 RAARDGLAAQLSW--QGTDQPAAQLTRDVLLPAAASGLDAWGVDAHDRDRYLGVIEARVR 449 Query: 340 SGLNEAQLM--------RDFVADGGSLIGLVKKHCEIWAG 371 SG A + +L + +++ E Sbjct: 450 SGRTGAAWQTETVRHLEERGLERISALHEMTRRYVEHARS 489 >UniRef50_D0WIV7 Putative glutamate--cysteine ligase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WIV7_9ACTN Length = 423 Score = 155 bits (392), Expect = 3e-36, Method: Composition-based stats. Identities = 56/389 (14%), Positives = 104/389 (26%), Gaps = 63/389 (16%) Query: 13 TLGIELEMQVVNPPGYDLS----QDSSMLIDAVKNKITAGEVKHD--------------I 54 TLG+E+E +V+ G L+ + ++ + + + D Sbjct: 38 TLGVEIEHFLVDNTGQPLTYSQPNGVADVLRTLSARYPDVSMHGDDILGVAKPHMNVTIE 97 Query: 55 TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE 114 + LE++ I ++ V A T + G P +E+ Sbjct: 98 PAAQLEISAGPFESIADMRFALGEFERDVAAALTPVAGRMVALGYDPMLVAADKELIPKA 157 Query: 115 RYQRTLENFGYL---IQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASP 169 RY + + V + S +DA + S P + +P Sbjct: 158 RYDIMNRYLSAISPSGPRMMRGSASTQVSIDYTSEEDAAAKMRVASALAPLLSLMCDNAP 217 Query: 170 YMQGTDTRFASSRPNIFSAFP------DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDL 223 +GT R I+ G + ++ + + +D+ + Sbjct: 218 VFEGTRAPHRLMRAEIWRYLDPDRCNTVPGCLDAGFSFADYANYILDVPAVVALDAEGEA 277 Query: 224 HWDIR------------------------PSPHFGT-VEVRVMDTPLTLSHAVNMAGLIQ 258 +D R P T VE+R D + A LI+ Sbjct: 278 RYDTRTFGDIFADRTMTHADIEHALSMVWPDARLKTYVEIRPADALP-IDLACAYEALIK 336 Query: 259 ATAHWLLTERPFKHQE-KDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEK 317 + E D + + G E R + L+E Sbjct: 337 GIFYGPALGALAAAFEGVDAQDVDDAKTAIMKRGYEAETF------SRNAGDMCDALVEM 390 Query: 318 IAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 G ++ L R V + A Sbjct: 391 AYEGL-PAGERGFLDPLARLVKQRITPAD 418 >UniRef50_A7HH96 Glutamate--cysteine ligase n=5 Tax=Cystobacterineae RepID=A7HH96_ANADF Length = 453 Score = 155 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 61/439 (13%), Positives = 107/439 (24%), Gaps = 90/439 (20%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQ-----DSSMLIDAVKNKITAG------------- 48 E + +G+E E ++ D ++ Sbjct: 28 RPREGWKVGLEHEKLMLRAGTLDPVPYEGPDGVGAVLRGFTRFGYEPFEEEGRIIASQND 87 Query: 49 --EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ 106 + + LEL+ D++ A + + A D +E G P+ Sbjct: 88 GLTISIE-PGGQLELSGRPFADVHVVAAELDRHIEKCAALARDLGVEFLAVGYRPWGTPA 146 Query: 107 RQEVCDNERYQRTLENF---GYLIQQA--TVFGQHVHVGCASGDDAIYLLHGLSRFVPHF 161 RY+ G L + D L P Sbjct: 147 TTPWMPKNRYKIMRPFLSARGRLAPDMMAMTASAQASFDFSGEKDLAEKLRVALAIQPAV 206 Query: 162 IALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMPWVSN----WQQFEALFRCLSYTT 215 AL A SP +QG + + S R ++ +G +P+ + + Sbjct: 207 TALYANSPIVQGREIGWKSYRTAVWEETDPARSGLLPFAFEPGFQAEPYRRYVEWALDVP 266 Query: 216 MI-----------------------------------DSIKDLHWDIRPSPHFGTVEVRV 240 MI D + + ++R G VEVR Sbjct: 267 MIFLRRAGAYRETGGRTFRRFLAEGLEGERATLSDWEDHLTTVFPEVRVK---GVVEVRA 323 Query: 241 MDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDP 299 D +A ++ E + + + A R L G D Sbjct: 324 ADACSPAMAKALLAFWKGVLYDRQARAAAWESVEAFTIAERRAFMRTAGREALAGRAPD- 382 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKI--------GASSAIEALHRQVVSGLNEAQLMRDF 351 R + E LL+ A + + L + SG + A + Sbjct: 383 ----GRSIQEIARGLLDVAAGGLCRQRCCGERGEDERVWLAPLVERATSGRSPADEALEV 438 Query: 352 VADGGSLIGLVKKHCEIWA 370 G + E Sbjct: 439 FRAGP------RALAEALR 451 >UniRef50_D0RQE4 Glutamate--cysteine ligase, (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQE4_9RICK Length = 442 Score = 154 bits (390), Expect = 4e-36, Method: Composition-based stats. Identities = 61/428 (14%), Positives = 119/428 (27%), Gaps = 90/428 (21%) Query: 6 FHVSE----PFTLGIELEMQVVNPPGYDLSQDSSM-------LIDA------------VK 42 F E F +G E E + + S ++ + Sbjct: 11 FKQGEKNPSDFKIGTEHEKFLFDIKTKKPVDFSEKGIVGIFNILKENQWTEIKEKENVIG 70 Query: 43 NKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF 102 K + + +EL+ C I+ + + K + QA L I G G P Sbjct: 71 LKKGNLSITLE-PGLQIELSGAPCGTIHDTCREVNLYLKELKQACAKLGLGIIGIGFVPN 129 Query: 103 QKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRF 157 K +RY + G L V+ +S DD S Sbjct: 130 VKINEIHKLKKKRYSIMRDYMPKVGTLGLDMMHRTAATQVNFDFSSEDDFRKKTKVASCL 189 Query: 158 VPHFIALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMPWVSNWQQ-FEALFRCLSYT 214 VP ++L + SP ++G F R NI+ +G +P+ + + +E Sbjct: 190 VPVAVSLFSNSPVLEGKLNGFIGYRTNIWQHTDDNRSGLIPFFFDKENSYEQYCDYALNV 249 Query: 215 TM--------------------------------------IDSIKDLHWDIRPSPHFGTV 236 M + + + ++R + + Sbjct: 250 PMYFVNRNDDVIDVSGKNFKDFVNGKLKETNHEEANLDDWANHLSTIFTEVRVKQY---L 306 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHW--LLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 E+R D+ + S ++ + +L E +E + A + G E Sbjct: 307 EIRPADSC-SWSGICSIPAFWTGILYDQNILEECFEICKEWKFKDVNQAYLDAGKKGFEA 365 Query: 295 VITDPHTGDRRPLTEDTLRLLEKIAPSAHKI--------GASSAIEALHRQVVSGLNEAQ 346 + + + + LE S ++ L V + N + Sbjct: 366 ELY------GKSILQYAKSFLELSQKGLQNRKKLNSNNDDESIFLKELFGFVENKKNLSN 419 Query: 347 LMRDFVAD 354 ++ + Sbjct: 420 ILIEEFEK 427 >UniRef50_C9RNX1 Glutamate--cysteine ligase GCS2 n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RNX1_FIBSS Length = 431 Score = 154 bits (390), Expect = 5e-36, Method: Composition-based stats. Identities = 41/369 (11%), Positives = 109/369 (29%), Gaps = 63/369 (17%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKN-------KITAGEVKHDITESMLELA-TD 64 G+E+E +V+ ++ + + + K+ + + +++ +LE Sbjct: 9 RFGVEMEFMIVDRDTLNVLPRADVPLGKDKDGNQLSDIEYDDIGLSNELVSHVLEFKCAH 68 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE------RYQR 118 + +F + + + + HPF ++ + Y R Sbjct: 69 PKSTFDGLGKRFFHEIRRANKKLEKINAMLLPSACHPFMDPAEMQLWPYDCLDIYQTYDR 128 Query: 119 TLEN--FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 G+ Q H+++ ++ L + +P A++A+SPY+ G T Sbjct: 129 IFNCKGHGWANLQ----STHLNLSFDGDEEFGELHAAIRLLLPLIPAIAASSPYLDGKYT 184 Query: 177 RFASSRPNIFSA----FPD---NGPMPWVSNWQQFEALFRCLSYTTMIDSIKD-----LH 224 + +R ++ P+ ++ ++ + + + Sbjct: 185 GYRDARIEVYRHNQDKVPEITGQVIPEQAYSYDEYNRMIFDKVKKAIAPYDTEHLLNHFF 244 Query: 225 WDIRPS---PHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 + R + G +E+R++D + + + L AT ++ Sbjct: 245 LNSRGAIARFDRGAIEIRLVDIQECPNADIAIVELEIATLKAIVNG-------------- 290 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 +F A R + + L++ + + L + Sbjct: 291 --KFAASRE---------NASEAPSAANSVPHTLKEYREFLRNFDTTR-LAELLTKTTKD 338 Query: 342 LNEA--QLM 348 A Sbjct: 339 AENAQIDWQ 347 >UniRef50_D1PL70 Putative glutamate--cysteine ligase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PL70_9FIRM Length = 410 Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats. Identities = 51/387 (13%), Positives = 106/387 (27%), Gaps = 65/387 (16%) Query: 12 FTLGIELEMQVVNPPGYDLS-QDSSMLIDAVKNKITAG-EVKHDI-------------TE 56 TLG+E+E V + G ++ + ++ ++ + + Sbjct: 25 LTLGLEVEHFVTHAGGEPVTFGEIQSVMRQMQQPYDTPIMIDGEYMGYTTEQYSVSLEPA 84 Query: 57 SMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY 116 +E++ + + ++ + L HP ++ + + +RY Sbjct: 85 CQVEISIMPQSSVLKIMDIYNQFYLQLSMTLAARGLRAWTVSYHPTRRAEELPLIPKQRY 144 Query: 117 QRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYM 171 + F G Q + V S D + + P F LS + Sbjct: 145 EAMDRYFKNTGSCGIQMMRATASTQLSVDYYSERDFVQKMRAACLLTPFFALLSDNAVQY 204 Query: 172 QGTDTRFASSRPNIFSAF--PDNGPMPWVSNWQ-QFEALFRCLSYTTMIDSIK------- 221 Q S R I+ G P + + FE + +I +++ Sbjct: 205 QAHRNNAYSVRTRIWQDVDSDRCGVPPHLMDPDFGFERYAETILTRPLIVALRGNRTKAV 264 Query: 222 -----------------------DLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 +D R + VE+R D A L++ Sbjct: 265 GRKSAQEIYGSHLLKKEVEHVLSMFFFDARLKTY---VEIRGADCMP-PKFIAAYAQLVK 320 Query: 259 ATA--HWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 L ++ + + C+ G G P+ ++ LL Sbjct: 321 TIFGSQAALQNVLRHYEGVNTGDIANAKMAVCKDGFNA----WVYGR--PIGKELAWLLL 374 Query: 317 KIAPSAHKIGASSAIEALHRQVVSGLN 343 + + +E L + VV Sbjct: 375 QARSRTPSQEERALLEPLAKLVVMKKT 401 >UniRef50_A9GBM5 Glutamate--cysteine ligase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GBM5_SORC5 Length = 458 Score = 151 bits (382), Expect = 4e-35, Method: Composition-based stats. Identities = 56/407 (13%), Positives = 106/407 (26%), Gaps = 81/407 (19%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSM-----LIDAVKNKIT------------------AGE 49 +G E E V+ ++ A+ + Sbjct: 37 RIGAEAEKFGVDARTGAAIPYEGERSVLNILQALVERHGWTPEHETPGGPLIALARAGAS 96 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 V + LEL+ +I+Q + S + + + L G G HPF + Sbjct: 97 VTLE-PGGQLELSGAPLENIHQICMEMSGHLAELRDISAELKLAWLGIGFHPFARQDDLS 155 Query: 110 VCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 RY G + AS + A+ L R P A+ Sbjct: 156 WVPKARYAIMRRYLPTRGAHGLDMMRRTATVQANFDYASEEAAMRALRVSLRLSPLVTAI 215 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFP--DNGPMP-WVSNWQQFEALFRCLSYTT------ 215 A SP+ +G S R ++ G + + ++F Sbjct: 216 FANSPFYEGALFGGRSYRAKVWLDVDAARQGLIRNVLERGRRFSDYVAWAVDAPMFLFKR 275 Query: 216 ---MIDSIKDLH-----------------WDIRPSPHFG------TVEVRVMDTPLTLSH 249 +I++ W++ + F T+EVR D+ + Sbjct: 276 DGEVIENTGQTFRDFLEHGFEGHRATRGDWEMHLNTLFPEVRLKRTLEVRGADSLP-ANL 334 Query: 250 AVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 + L + L E + + + R + L +PL Sbjct: 335 VCALPALWAGILYDARALDEADALSESFRFDELEAVRPKIAERALRATF------RGKPL 388 Query: 308 TEDTLRLLEKIAPSAHKI--------GASSAIEALHRQVVSGLNEAQ 346 RL+ + + ++ L + G + A Sbjct: 389 AALAERLVAIASGGLARRARLNKNGKDERVHLDRLSALIAKGQSPAD 435 >UniRef50_B2SNT5 Glutamate--cysteine ligase n=3 Tax=Xanthomonas oryzae pv. oryzae RepID=B2SNT5_XANOP Length = 393 Score = 150 bits (379), Expect = 8e-35, Method: Composition-based stats. Identities = 61/405 (15%), Positives = 104/405 (25%), Gaps = 52/405 (12%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M + +G E E G+ L D + V + LE Sbjct: 1 MLASGEKPEAQWRIGTEHEQF-----GFRLDDLRPPTFD--GERGIEASVTLE-PAGQLE 52 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL 120 L+ I+ + + V Q A L G G P + + +R++ Sbjct: 53 LSGAPLHTIHDTCVEVGSHLNEVKQVADQLGLGFLGMGFQPKWSREAMPLMPQDRHKIMQ 112 Query: 121 ENF---GYLIQQATVFG------------------------QHVHVGCASGDDAIYLLHG 153 G L V++ AS D + Sbjct: 113 AYMPNVGALGLDMMTRTRTRTRTRTRTCTCTCTCTCTCTCTVQVNLDYASEADMVKKFRV 172 Query: 154 LSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAF--PDNGPM-PWVSNWQQFEALFRC 210 P AL A SP+ +G + S R +I+ G + + +E Sbjct: 173 SLALQPIATALFADSPFTEGKPNGYLSYRSHIWIDTDADRTGILDFVFEDGFGYERYLDY 232 Query: 211 LSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPF 270 L M S D + I S +R D ++ L + Sbjct: 233 LLDVPMYFSYHDGTY-IDASGQSFRDFLRGADARP-WGRLCALSAFWVGL---LYDDPAL 287 Query: 271 KHQEKDYLLYKFNRFQACRYGL---EGVITDPHTGDRRPLTEDTLRLLEKIAPSAH---- 323 + + A R G+ + + + TE L + A Sbjct: 288 DAAWDLVKDFSRSERHALRDGVPRHALKLPFRNDSVQNLATEAVKIALAGLRRRARLNRD 347 Query: 324 KIGASSAIEALHRQVVSGLNEAQLMRDFVAD--GGSLIGLVKKHC 366 S +E L + SG A+ G + + + Sbjct: 348 VQDESRFLEPLVEILHSGETAAERKLALYHGVWQGDIDRVFGEFA 392 >UniRef50_C8WKE9 Glutamate--cysteine ligase n=2 Tax=Coriobacteriaceae RepID=C8WKE9_EGGLE Length = 427 Score = 150 bits (379), Expect = 9e-35, Method: Composition-based stats. Identities = 56/397 (14%), Positives = 110/397 (27%), Gaps = 69/397 (17%) Query: 9 SEPFTLGIELEMQVVN----PPGYDLSQDSSMLIDAVKNKITA----------------G 48 P LGIELE +V+ P Y + ++ + Sbjct: 33 GGPGELGIELEQIIVHDDLSPVSYSGEHGVAWVLRQLAADYPRTTTDEHGDLLGVARPSE 92 Query: 49 EVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ 108 V + + +EL+ D+ A F + + + G HP + Sbjct: 93 AVTIE-PAAQIELSAGPFADLATARDTFEGFAQRLSDVLEPAGEKALAIGYHPSATARSL 151 Query: 109 EVCDNERYQRTLENFG---YLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIA 163 E+ RYQ G V + S D + L VP Sbjct: 152 ELIPKRRYQFMDLYLGERDIYGPCMMRGSASTQVSIDYTSTADCLRKLRLAFALVPMLSL 211 Query: 164 LSAASPYMQGTDTRFASSRPNIFSAF--PDNGPMPWV----SNWQQFEALF--------- 208 + +P +G R +I+ G +P V + +++ Sbjct: 212 MCDNAPVFEGKPREHQLVRTDIWQHVDNDRCGLVPDVLDPSFDLRRYAEYILDTVAILIP 271 Query: 209 -------------------RCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 R ++ + ++ D+R + +E+R D + + Sbjct: 272 CQQQRWCYSDRTFGDIYAARTMTRAEVEHAVSMFFTDVRLKTY---IEIRPADAMP-IPY 327 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + A LI+ + + + + + A + L + RP+ E Sbjct: 328 VIAYAALIKGL---FYAPTSLDAMDGLFADVRRDDYLAAQDALMERGYEAEVYG-RPVAE 383 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 R+++ +E L V + A Sbjct: 384 LCDRIVKIARDGLAD-EEQGFLEPLADLVARRVTLAD 419 >UniRef50_C4GD43 Glutamate--cysteine ligase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GD43_9FIRM Length = 418 Score = 150 bits (378), Expect = 1e-34, Method: Composition-based stats. Identities = 69/420 (16%), Positives = 127/420 (30%), Gaps = 68/420 (16%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P F G+E E Q V P G+ L + D ES LE+ T Sbjct: 9 PTFTQGG---FGLEEENQRVTPEGF--------LAQTDHPFGDDPVLDRDFCESQLEIIT 57 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHH--LEICGGGTHP-FQKWQRQEV-------CDN 113 V + + ++ V + + + P + + + + Sbjct: 58 GVHHNPRELVKALGDKRREVARFLAGQNTPELLWPFSNPPCLRSEKDIRIAQFVGEKAEK 117 Query: 114 ERYQ-RTLENFGYLIQQATVFGQHVHVGCAS------GDDAI-------YLLHGLSRFVP 159 Y+ +G ++ ++ G H + ++ + L L + Sbjct: 118 TVYRNYLAGKYGR--KKQSLCGIHFNFSYPQAFLDCLREEGVSADQIYLNLAEKLLAYSW 175 Query: 160 HFIALSAASPYMQGTDTR----------FASSRPNIFSAFPDNGPMPWVSNWQQFEALFR 209 +AL+AASP M + ++S R + + + P+ + Sbjct: 176 LIVALTAASPLMDASFEGGKPGEILAGIYSSYRCSDRGYWNEFEPVLDFDAIPNYLDSMN 235 Query: 210 CLSYTTMIDSIKDLHWDIRPSPHF-----------GTVEVRVMDTPLTLSHAVNMA--GL 256 T + S +L++ +R P +E+R++D ++ + Sbjct: 236 YYVETGKLYSAAELYYPVRLKPKGTNALDKLREGVNHIELRMLDINPLRDEGIDPSDLEF 295 Query: 257 IQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 + +L N QA Y LE V G PL E L +L Sbjct: 296 LTLLLLYLTARPKMDLSVMRQRRAMRNMKQAASYPLEKVSLFWTDGQMHPLPELALEILA 355 Query: 317 KIAPSAHKIGASSAIEALHRQVVS-GLNEAQLMRDFVAD---GGSLIGLVKKHCEIWAGD 372 + GA AI ++ A + D + GG L ++ I GD Sbjct: 356 DMENVL---GAHEAISRQIDKIKDPDRCYASQILDRYGEDYIGGGLAR-ARELAGISEGD 411 >UniRef50_D1ACB6 Glutamate/cysteine ligase family protein n=2 Tax=Streptosporangineae RepID=D1ACB6_THECD Length = 399 Score = 147 bits (371), Expect = 6e-34, Method: Composition-based stats. Identities = 68/396 (17%), Positives = 114/396 (28%), Gaps = 76/396 (19%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYD---LSQDSSMLIDAVKNKITAGEVKHDITESMLELA 62 F P +G E E V++P + +A + ++ LEL+ Sbjct: 18 FKTGPPGKVGAETEWLVIDPADPAAHVPLERVRAAAEAGGPLPGRSVITYE-PGGQLELS 76 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + VC + S V L++ G G P ++ + Q + RY+ + Sbjct: 77 SRVCDGLADLHEALSQDLASVRARLAADGLDLVGRGVDPLRRPRLQA--AHPRYRCMYDY 134 Query: 123 -----FGYLIQQAT--VFGQHVHVGC-ASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 + V + A DA+ P +A A SP G Sbjct: 135 FAGGGYRETGATMMCSTASVQVCLDIGADPADALRRWRLAHALGPVLVAAFANSPLRAGR 194 Query: 175 DTRFASSRPNIFSAFP----------DNGPMPWVSNWQQFEALFRCLSY----------- 213 T S+R I++A GP W ++ + Sbjct: 195 RTGLRSTRQAIWAALDPCRTRPVLEAGTGPADPCRAWTRYAIDAPVMLTRPRPGTSDGWT 254 Query: 214 ------------------TTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAG 255 + L +RP G +E+R++D V +A Sbjct: 255 GAPGMTFGEWMDKGEPCLDDFAYHLSTLFPPVRPR---GWLELRMIDALPLRYWPVPVA- 310 Query: 256 LIQATAHWLLTERPFKHQEKDYLLYKFNRF-QACRYGLEGVITDPHTGDRRPLTEDTLRL 314 A LL + +D R+ A R+ L TDP L R Sbjct: 311 ----VATALLDDPQAGRIAEDAARPVAGRWGAAARHAL----TDPA------LALAARRC 356 Query: 315 LEKIAPSAHKIGASSAI----EALHRQVVSGLNEAQ 346 + ++GA+ + + R V G A Sbjct: 357 FAAALQALPRLGAAELVPLVADYARRYVERGRCPAD 392 >UniRef50_A7I8T0 Glutamate--cysteine ligase, GCS2 n=6 Tax=Euryarchaeota RepID=A7I8T0_METB6 Length = 370 Score = 146 bits (370), Expect = 9e-34, Method: Composition-based stats. Identities = 51/391 (13%), Positives = 121/391 (30%), Gaps = 57/391 (14%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELATD- 64 T+G E E + + + S +I A+ + + + ++ +S++E Sbjct: 1 MTVGTEHEYSINDAH-FTALPVSDQIIKAICGRFESEIRFGEVNLGKELQKSVIEFVPRT 59 Query: 65 VCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN------ERYQR 118 Q + + + + G G HP R V D+ E Y R Sbjct: 60 PASGPAALEAQIFSGIEKFYRVFPAR-YHLLGLGMHPTLTLDRAIVWDHDEGEYYEAYDR 118 Query: 119 TL--ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 G+L + +++ A D + + + +P+ IALSA+SP ++G T Sbjct: 119 LFNIRQHGWL----NIQALQINLSYAGEKDLLVQYNRIRTLLPYLIALSASSPMVEGRLT 174 Query: 177 RFASSRPNIFSA-------FPDNGPMPWVSNWQQF---EALFRCLSYTTMIDSIKDLHWD 226 +R + +S+ ++ + + + + + Sbjct: 175 GAMDNRLLFYRENQKEIPGICSGIIPARLSSVAEYKSAQEVIYTELRERDAAILCEEWLN 234 Query: 227 -----IRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 IR S +E++ +D + + + + T P + + L Sbjct: 235 SSGLIIRFSRQC--LEIKALDEQECVRSDMAFVAFVSSLLRC--TTLPVESDQDSLLALT 290 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 A R G G++ + L A + + ++ Sbjct: 291 E---TAIRQGTAGLLP------------ELEALYSHAWRKA-TAEERQYLPVIKERIAK- 333 Query: 342 LNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 + A+ + + ++ ++ + + Sbjct: 334 GSLAEQIAERYRKEQAIEPVLADLAQCLRAN 364 >UniRef50_Q5ZYJ4 AF2307 n=4 Tax=Legionella pneumophila RepID=Q5ZYJ4_LEGPH Length = 418 Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats. Identities = 57/394 (14%), Positives = 137/394 (34%), Gaps = 43/394 (10%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKN------KITAGEVKHDITESMLEL-ATDVC 66 LGIE+E +V+ ++ S +++ A+ ++ + +++ +LEL Sbjct: 22 LGIEIEYMLVDKESLNVQPKSDLILRALAGHQVNEIELGDIAISNELVLHVLELKNNGPK 81 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ----RQEVCDNERYQRTLEN 122 A F + + H+L + G HP+ R +++ Y + Sbjct: 82 PLHVPVAEHFQKTIRELQPLLAQHNLLLLPTGAHPWMDPNTETIRWPHGNHDIYNQFNSI 141 Query: 123 FGYLIQQ-ATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 F A + HV++ ++ ++ L + +P A++A++P++ G T S Sbjct: 142 FNCQGHGWANLQSMHVNLPYSNEEEFCQLHNATRLILPLLPAIAASTPFLDGQATGLLDS 201 Query: 182 RPNIF----SAFPD-NG--PMPWVSNWQQF-EALFRCLSYTTMIDSIKDL----HWDIR- 228 R + P +G ++ +++ E + + + + + R Sbjct: 202 RLYFYSRNQQRIPSISGDIIPEFIRTEREYQEQILEPMYRDISPYDPEGILQYQWLNSRA 261 Query: 229 --PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEK-DYLLYKFNRF 285 P +E+R++D+ + + +A I A + + F D K+ Sbjct: 262 AIPKFDMKAIEIRILDSQECVEADIAIAKAINAILKYWQSTSNFYLDNPCDTKSLKYVFD 321 Query: 286 QACRYGLEGVI-------TDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQV 338 + + GL I + L+E+I+ H++ + + Sbjct: 322 ETIKNGLSCHIDNKRLLEQWQLPLQGMSVNTIWSLLIERIS---HELDRKQQLA--LELI 376 Query: 339 VSGLNEAQLMRDFVAD---GGSLIGLVKKHCEIW 369 + N ++ + + SL + + Sbjct: 377 LKQGNLSERILKACSSCVNHDSLKQVYTQLAHCL 410 >UniRef50_A6TWY9 Glutamate--cysteine ligase n=2 Tax=Alkaliphilus RepID=A6TWY9_ALKMQ Length = 446 Score = 144 bits (364), Expect = 4e-33, Method: Composition-based stats. Identities = 59/408 (14%), Positives = 112/408 (27%), Gaps = 75/408 (18%) Query: 11 PFTLGIELEMQVVNPPGYDLS-----QDSSMLIDAVKNKITAGEVKHDI----------- 54 LG E E VV Q ++ A+ K E + D Sbjct: 22 ELKLGAEFEHIVVWKDTMKSVSYYEEQGIEDILKALLEKGYEAEYEGDYLIALKKEAYYI 81 Query: 55 ---TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 LE++ C I + + ++ ++ + G HP + Sbjct: 82 TLEPGGQLEISVVPCSTIESVQSIYFQFLEEIIPIMENNGQLLLAIGYHPKSSIKEIPFN 141 Query: 112 DNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 RYQ G Q V + + +D I + P ++ Sbjct: 142 PKVRYQYMSNYLKDKGTYSQHMMKGTAAIQVSIDYRNEEDFIKKFKVANFLSPLLHLITD 201 Query: 167 ASPYMQGTDTRFASSRPNIFSAF--PDNGPMPWVSN----WQQFEALF-----------R 209 SP +G D R I+ +G +P V N ++ + Sbjct: 202 NSPRFEGEDYLGHGLRSVIWQNTDKDRSGVIPGVMNERFGYEAYAKYILGIPPILMKKEG 261 Query: 210 CLSYTT----------------MIDS-IKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVN 252 L T I+ + + D+R + +E+RV D+ + Sbjct: 262 QLIETGNQSIGEVLKENDLTGEEIEHLLTMVFPDVRVKRY---IEIRVGDSLPYPYN-FA 317 Query: 253 MAGLIQATAHWLLTERPFKHQEKDYLLYKFNR----FQACRYGLEGVITDPHTGDRRPLT 308 L++ + Y L +A R + G + Sbjct: 318 YIALLKGIFY------DETVLNYLYKLANGAEGDQIEKAKRSMHKNAFKGWFFGK--TIY 369 Query: 309 EDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGG 356 + L + + ++ L ++S N + LM++ + G Sbjct: 370 DFIRILFDLSKKGLTE-EEIKILKPLETLIISRKNLSLLMKEDIEKSG 416 >UniRef50_UPI00016C5767 glutamate--cysteine ligase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C5767 Length = 444 Score = 141 bits (356), Expect = 4e-32, Method: Composition-based stats. Identities = 53/418 (12%), Positives = 108/418 (25%), Gaps = 74/418 (17%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLS---QDSSMLIDAVK------NKITAGEVKH----- 52 + + +G E E ++ ++ A+ AG + Sbjct: 29 KPTPAWRVGAEFEKFALDRGTGQQIGFDAGIEGVLHALATHFAWEPHTEAGRLTTLTRGR 88 Query: 53 -----DITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 + LEL+T +++ +F + + G PF + Sbjct: 89 STVSVE-PGGQLELSTAPTARLSELRAEFETHLHELRAVTDPAKVAWVAAGVTPFSAVED 147 Query: 108 QEVCDNERYQRTLENFGY-----LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFI 162 + R++ E L V S DA L + P Sbjct: 148 IPLNPRPRHRLMAEYLPTRCPHGLHMMKATASTQVTFDYKSEADAGRKLAVALKLGPVVN 207 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAF--PDNG-PMPWVSNWQQFEALFRCLSYTTMI-- 217 AL A +P G T F S R +I+ +G +++ F+ + + ++ Sbjct: 208 ALFANAPLYAGRRTEFVSFRGHIWHNMDPDRSGLLTDLLADEITFDRWVQFVLDVPLLLL 267 Query: 218 ------------------------DSIKDLHWDIRPSPHF------GTVEVRVMDTPLTL 247 WD+ S F +EVR D Sbjct: 268 TDGESLKPAPGATFREFLHKGIDGRHPTRHDWDVHLSTVFTEARLKRFMEVRGADATPAP 327 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDY--LLYKFNRFQACRYGLEGVITDPHTGDRR 305 + + + + + ++ + R G+ Sbjct: 328 -LVLAVPAVWKGLLYDAAALAAATDLAGNFTPEELRPLSEAIARRGMRAE------HRGI 380 Query: 306 PLTEDTLRLLEKIAPSAHKIGASS-AIEALHRQVVSGLNEAQLMRDFVADGGSLIGLV 362 PL + + G +E + + +G + + GG + L+ Sbjct: 381 PLARWCHEVTAIADTGLKRQGEDVTFLEPVRELLDAGRSPGE----MWPRGGDVAQLL 434 >UniRef50_A0M1L9 GCS2 glutamate--cysteine ligase n=3 Tax=Flavobacteriaceae RepID=A0M1L9_GRAFK Length = 406 Score = 140 bits (354), Expect = 7e-32, Method: Composition-based stats. Identities = 48/395 (12%), Positives = 114/395 (28%), Gaps = 44/395 (11%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELAT-DVC 66 GIELE +V + ++ L IT+ E +++ ++E+ T Sbjct: 9 FGIELEYMLVKRSNFKVNPIVDQLFIEKHGSITSDTENGKIEWSNELVAHVVEMKTNGPT 68 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 D+ F+ + + + + +HP Q + Y + + + Sbjct: 69 NDLLDLDSLFAENVREMNKHLQKFDTFLLPSASHPLMNPQTETKLWEHHYNKIYSLYNKI 128 Query: 127 -----IQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASS 181 + V H+++ + L + +P LSA+SP + G T F S Sbjct: 129 FNCKGHGWSNVQSMHINLPFFDDAEFEKLHAAVRILLPIIPGLSASSPVLDGKFTGFKDS 188 Query: 182 RPNIF----SAFPD-NG--PMPWVSNWQQFEALF-RCLSYTTMIDSIKDL----HWDIR- 228 R + P G V N + + +++ + R Sbjct: 189 RMEFYKSNQKEIPHMTGKIIPEQVFNKADYNKTIFEPIINAIKPFDTENILDHHFLNSRG 248 Query: 229 --PSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR-- 284 +E+RV+D S + +A I ++E +++ Sbjct: 249 AISRFDRNAIEIRVIDIQENPSADIAIAAFIVEVLKLFVSEELVSLEDQKSWHEDDLFLI 308 Query: 285 ----FQACRYGL---EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQ 337 + L + + + + L ++ + Sbjct: 309 LDEVIGSAETTLITDKKYLAIFDLQREADVKKIWKILYARVGSKLSENHQKR-----IEF 363 Query: 338 VVSGLNEAQLMRDFVADG---GSLIGLVKKHCEIW 369 ++ + + + + + + + + E Sbjct: 364 ILQHGSLSTRILKAIRNDFSKEHIKKVYFRLAECL 398 >UniRef50_O27977 Uncharacterized protein AF_2307 n=2 Tax=Archaeoglobaceae RepID=Y2307_ARCFU Length = 365 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 59/363 (16%), Positives = 132/363 (36%), Gaps = 64/363 (17%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE------VKHDITESMLELA-TDVC 66 +G E E + + ++ S ++ + + + ++ + ++EL Sbjct: 2 IGPEHEFSIND-ENFNPVPISDEILKKIGGRTVNEAKLGRVVIGKELQKHVIELKPARPF 60 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN------ERYQRTL 120 +++ + +L ++ G G HP + + +V ++ + Y R Sbjct: 61 ESLSEFEETMQEGVEELLSVMD--GYKLLGLGMHPLLRLEDAKVWNHRDRRIYQAYDRLF 118 Query: 121 E--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT---- 174 G+L + +++ +S +A+ L + + +P+ A+++ASP +G Sbjct: 119 NIKQHGWL----NIQSYQLNIPFSSEKEAVELHNKIRVLLPYIAAVASASPICEGKSYYV 174 Query: 175 DTRFASSRPNI--FSAFPDNGPMPWVSNWQQFEALF----RCLSYTTM-------IDSIK 221 DTR R N ++ +S+ +++ ++ L ++S Sbjct: 175 DTRLYFYRINQKEVPEICNDVIPERISSLKEYRSILNGIYEELRRKGAYVLCREWVNSRG 234 Query: 222 DLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 + +R S +E++VMD + V + I+A L E P D L+ K Sbjct: 235 VI---VRFSRKC--LEIKVMDEQECIKSDVALTAFIRAILRAELEELP-----VDVLIEK 284 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 N A R G T +P + LL+K A + ++ + ++ G Sbjct: 285 LN--SAMRSG---------TEKLKP---ELKELLKKSKEHADE-EERRYMKVVKLRIEEG 329 Query: 342 LNE 344 Sbjct: 330 SLG 332 >UniRef50_A8UG36 CBS domain pair protein n=1 Tax=Flavobacteriales bacterium ALC-1 RepID=A8UG36_9FLAO Length = 621 Score = 137 bits (346), Expect = 6e-31, Method: Composition-based stats. Identities = 41/431 (9%), Positives = 117/431 (27%), Gaps = 91/431 (21%) Query: 5 DFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATD 64 F +G E E+ +V+ Y S ++ ++D + + ++ +E D Sbjct: 37 AFEKGTQ-RIGAEQELCLVDNY-YRPSFNALKILDKIND----PHFTTELGLFNIEANLD 90 Query: 65 VC----RDINQAAGQFSAMQKVVLQAATDHHL-EICGGGTHPFQKWQRQ---EVCDNERY 116 + ++ + + +A ++ G P K + + ++RY Sbjct: 91 PLVLNGKCFSKLEEDLYGLIEKAHLSAEAIEKNKVILAGILPTFKRKDLVFKNMTPHKRY 150 Query: 117 QRTLENFGYLIQQ----------------------ATVFGQHVHVGCASGDDAIYLLHGL 154 + + + + A VH+ + +D + + Sbjct: 151 KVLNDVMKSIRGRDFRVQVKGVDELILDHESILFEACNTSFQVHLQI-NLEDIVDQYNWS 209 Query: 155 SRFVPHFIALSAASPYMQGTDTRFASSRPNIFSA-----------------------FPD 191 +A+ SP + G + ++ +R +F + Sbjct: 210 QAIAGPILAVMTNSPLLLGRE-LWSETRIALFQQSIDLRNKSHLLREQKPRVSFGNDWFK 268 Query: 192 NGPMPWV-SNWQQFEALFRCLSYTTMI---------------DSIKDLH-WD-----IRP 229 + + + ++ L + L+ W+ + Sbjct: 269 DSILDLFTDDVARYTPLVTSEFENDSLSDLKNGIKPKLKALNLHNGTLYKWNRVCYGVHK 328 Query: 230 SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACR 289 + +E R + ++ + A + + + + K N +A R Sbjct: 329 NVAHLRIENRYIPAGPSIKDEIANAMFWVGVMLGMPDDCRSIWKRMGFKDAKGNFIKAAR 388 Query: 290 YGLEGVITDPHTGDRRPLTEDTLR-LLEKIAPSAHKI-----GASSAIEALHRQVVSGLN 343 G++ G + LL K + + +++ ++ Sbjct: 389 TGMDTYFNWFDKG--ISAKQLAKDFLLPTARKGLLKANVDIDDIDFYLNIIKKRIDKNIS 446 Query: 344 EAQLMRDFVAD 354 ++ + Sbjct: 447 GSKWLVRSSRK 457 >UniRef50_D2RSK6 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RSK6_9EURY Length = 517 Score = 135 bits (341), Expect = 2e-30, Method: Composition-based stats. Identities = 58/458 (12%), Positives = 102/458 (22%), Gaps = 111/458 (24%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV----CRDI 69 +G+E E V L + L++ + + ++ E+ T + Sbjct: 48 VGLEYEFYAVKNDDCALRRVPRRLLELIG-------FEKELGLHNAEMTTSPQPMNAHGL 100 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR---------------------- 107 + A + L + + Sbjct: 101 AAQESEVKARLQTALNVTQSERMRLVSDALWTLPPEGEDATTYLTDSVERTTTDDDGTER 160 Query: 108 -----QEVCDNERYQRTLENFGYLIQQATVFGQHV------------------HVGCASG 144 + D+ RY + HV H A Sbjct: 161 SFRIATNMSDSARYHAMANTDQAESAGMCIQAPHVSLQADTVMPESLITSIQPHYQVAHA 220 Query: 145 DDAIYLLHGLSRFVPHFIALSAASPYM-----QGTDT-------RFASSRPNIFSAF--- 189 D + R +AL SP+ T + R ++F Sbjct: 221 PDLPDYFNYALRIAGPLLALGVNSPFFPADLYDDEATPEEILRDGWMEHRISVFETVLND 280 Query: 190 PDNG------------PMPWVSNWQQFEALFRCLSYTTMIDSI---------KDLHWDIR 228 P G + + + IR Sbjct: 281 PTTGEGKVRFPRDLGTVEEAIDRIADDDTIVPMPIEAGERFDDQFPHFSRKHGTYWRWIR 340 Query: 229 PSPHFGT-------VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 P T +E R + T+ +V L T E D+ + Sbjct: 341 PVFGGPTRSAANARIEFRPIPAQPTVRDSVAFLAAFAGLMESL-TRLEHPVLELDWQRAR 399 Query: 282 FNRFQACRYGLEGVITDPHTGDRRP--LTEDTLRLLEKIAPSAHKIGASS-----AIEAL 334 N + A GLE + + LL G S + L Sbjct: 400 ENFYAAMVDGLEAELNWITNDGKETSDTLALYEDLLAHAEDGLTNRGLSEEEAAKYLYPL 459 Query: 335 HRQVVSGLNEAQLMRD----FVADGGSLIGLVKKHCEI 368 R+V + A R+ +ADG L ++ + Sbjct: 460 RRRVRQTVTPASWKRERVRSALADGADLDAAIEAMQQA 497 >UniRef50_C0EWU2 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EWU2_9FIRM Length = 819 Score = 135 bits (340), Expect = 3e-30, Method: Composition-based stats. Identities = 56/403 (13%), Positives = 112/403 (27%), Gaps = 69/403 (17%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 GIE+E V G L + D +E+ E+ T V I Sbjct: 409 DGAFGIEMESLRVVGDGM--------LSQTAHPFPGDAHIVRDFSENQTEINTGVNESIE 460 Query: 71 QAAGQFSAMQKVVLQAATDHHL--EICGGGTHP-FQKWQRQEVCD-------NERYQR-T 119 A + + + + + P + + Y+ Sbjct: 461 AAIEELKGHTRRIQEKLKALPEPELLWPFSNPPYIGGEKDVPIAQFDGKDAHKTAYREYL 520 Query: 120 LENFGYLIQQATVFGQHVHVGCA-----------SGDDAIYLLHGL--------SRFVPH 160 + +G + T G HV+ + S D + + L + + Sbjct: 521 SDKYGRY--KMTFSGSHVNFSFSEDLLRADFALQSEPDFMKYKNKLYLELAQKIAVYGWI 578 Query: 161 FIALSAASPYMQG-----------TDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFR 209 +A++AASP + T +S R + + + P S+ + Sbjct: 579 LVAVTAASPIVDSSFMEKGVYGKSVFTGLSSVRCSELGYWNEFPPTFDYSDIDSYVNSIE 638 Query: 210 CLSYTTMIDSIKDLHWDIRPSPHF------------GTVEVRVMDTPL--TLSHAVNMAG 255 ++ + +L++ IR P +E+R+ D Sbjct: 639 KYVKNGLLKAPSELYYPIRLKPAGENNLISLRKNGIDHIELRMFDLNPLTGAGIDARDVK 698 Query: 256 LIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLL 315 Q WL T + +KD + N A Y L+ V R + + L+++ Sbjct: 699 FAQLLMVWLATMPSWYVSKKDQVNAVQNFKNAAHYDLKTVKIARTEKRARSIVHEALKVI 758 Query: 316 EKIAP---SAHKIGASSAIEALHRQVVSGLNEAQLM-RDFVAD 354 + ++ + + V R + Sbjct: 759 GWMKEFYQGLKMDDVQQILDFEYEKFVDPEKRYAWQVRKQYQE 801 >UniRef50_B1MFR8 Glutamate--cysteine ligase GshA n=1 Tax=Mycobacterium abscessus ATCC 19977 RepID=B1MFR8_MYCA9 Length = 416 Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats. Identities = 59/381 (15%), Positives = 101/381 (26%), Gaps = 69/381 (18%) Query: 5 DFHVSEPFTLGIELEMQVVN---PPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLEL 61 F ++ +G+ELE V P + D+V + + + + +EL Sbjct: 28 AFADAQVGAVGLELESHTVELTAPHRRITWNRLREVGDSVPDLPGSSAITFE-PGGAVEL 86 Query: 62 ATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLE 121 + C D+ A A +++ + + GT P ++ +R V RY Sbjct: 87 SGPPCSDVWSAISSMRADHEILTAVYRGAGIALASLGTDPLRRPER--VNPGARYVAMER 144 Query: 122 NFGYLI-----QQATVF--GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGT 174 +FG Q V+V + R P ALSA+SP + G Sbjct: 145 HFGAAGYGETALQMMTCTASLQVNVQSGTPRQWRDRFVLAQRIGPTMAALSASSPMLTGR 204 Query: 175 DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMID---------------- 218 T ++R I+ P E+ ++ Sbjct: 205 PTGRRNTRQWIWDNLDPRRCAPVEIGVDPTESWVEYALRAPVMLVRNKDGADAVVTRVPF 264 Query: 219 ----------------------SIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGL 256 + L +RP +E+R +D Sbjct: 265 QSWVDGTMPLAGRAPTTEDLDYHLTTLFPPVRPRR---WLELRYLDAAPDWWWPAL--AF 319 Query: 257 IQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPL-------- 307 A L + + N + A R GLE Sbjct: 320 T---AVAALDDPQVADIAAEIAEPVGNAWGVAARIGLEDPALHAAAHRLVSAACAVAPPE 376 Query: 308 -TEDTLRLLEKIAPSAHKIGA 327 D LLE++ Sbjct: 377 LATDMEFLLERVEQGRCPADD 397 >UniRef50_C8XBM8 Glutamate/cysteine ligase family protein n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8XBM8_NAKMY Length = 445 Score = 132 bits (332), Expect = 2e-29, Method: Composition-based stats. Identities = 68/407 (16%), Positives = 108/407 (26%), Gaps = 76/407 (18%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSM-----LIDAV--------KNKITA 47 +P F P +G+ELE V L+ LID + Sbjct: 31 IPRTFFKNGPPHRVGLELEFLVAGTGDDALATHYPHEQYPHLIDRLIDGPPDSPPGGGLD 90 Query: 48 GEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR 107 G V + +EL++ + + + A + G G P + +R Sbjct: 91 GRVTVE-PGGQVELSSRPGDSLAATVDTVHHDLARLRRRARGRGARLVGLGVDPIRPPRR 149 Query: 108 QEVCDNERYQRTLENFGYLIQQ---ATVFGQHVHVGCASGDDAIYLLHG---LSRFVPHF 161 + D RY+ F V V + A+ L L P Sbjct: 150 --ITDQPRYRAMERYFRPWGATGPAMMCSTASVQVNVEAATPAVDLHRRWELLHAIGPTL 207 Query: 162 IALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMPWVSNWQQFEALFRCLSYTTMID- 218 +A A SP G T F S+R I+ G P A R ++ Sbjct: 208 VAAFANSPRRLGRATGFQSTRQAIWQELDPARTGAPPRAPGEDPATAFTRWSLDAPVMLI 267 Query: 219 ---------------------------------------SIKDLHWDIRPSPHFGTVEVR 239 + L +RP G +E+R Sbjct: 268 RREHDDWSAPPELSMRSWIRHGRRAVPDRPAPTVDDLAYHLSTLFPPVRPR---GHLEIR 324 Query: 240 VMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDP 299 +D V A + ++ E ++ A R G+ DP Sbjct: 325 YLDALPGCWWIVPAAVIAALLDDPAAADQARATCEPVQEHWR----TAARSGVR----DP 376 Query: 300 HTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQ 346 G T + P+A + L R + G + A Sbjct: 377 ALGRAATALLTTAAQALRRDPTAARFADPVE-GYLQRWTLRGRSPAD 422 >UniRef50_C7ML88 Gamma-glutamylcysteine synthetase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7ML88_CRYCD Length = 429 Score = 132 bits (332), Expect = 3e-29, Method: Composition-based stats. Identities = 46/316 (14%), Positives = 98/316 (31%), Gaps = 67/316 (21%) Query: 10 EPFTLGIELEMQVV-NPPGYDLSQDSSM-------LIDAVKN----------------KI 45 P LG+E+E VV +P + + +++ + + Sbjct: 40 APGALGVEVEHFVVTDPDKRPVFYEPRDGKLGVRDVLEYLAQWYPVVDRNSAGEVLALRS 99 Query: 46 TAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW 105 + + + LE++ ++Q + ++V+ +H ++ G G HP + Sbjct: 100 DEASITIE-PAAQLEISIAPLARVDQVKSAYEHFRRVLDPFLHEHAFQLLGLGYHPTTQA 158 Query: 106 QRQEVCDNERYQRTLENFGYLIQ---QAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPH 160 E+ +RY+ E+F ++ + V V S DA+ P Sbjct: 159 LDMELIPKQRYRFMDEHFHHIGTHGERMMRASASTQVSVDFTSEVDAVEKFRVALALGPI 218 Query: 161 FIALSAASPYMQGTDTRFASSRPNIFSAFP--DNGPMP-------WVSNWQQF------- 204 + +P +G +R N++ G +P ++ + Sbjct: 219 LAYICDNAPVFEGKPNTIPLARLNLWRDVDNARCGIIPGAFDDGWDFGSYADYLLGASPI 278 Query: 205 ----------------EALFRCLSYTTMIDSI-KDLHWDIRPSPHFGTVEVRVMDTPLTL 247 +A L + I+ + D+R VE+R D+ Sbjct: 279 FVTQPEVRAVGETLARDAYGDRLMDQSDIEHLISMFWPDVRLKQF---VEIRPADSMP-A 334 Query: 248 SHAVNMAGLIQATAHW 263 A LI+ + Sbjct: 335 DCIYGYAALIKGIFYA 350 >UniRef50_A8M1F4 Glutamate--cysteine ligase GCS2 n=2 Tax=Salinispora RepID=A8M1F4_SALAI Length = 411 Score = 131 bits (330), Expect = 4e-29, Method: Composition-based stats. Identities = 57/385 (14%), Positives = 107/385 (27%), Gaps = 80/385 (20%) Query: 6 FHVSEPFTLGIELEMQVVNPPG--------------YDLSQDSSMLIDAVKNKITAGEVK 51 F P LG ELE V + S + + + V Sbjct: 28 FKTGPPRWLGTELEWIVHDAVDPARPVGASRLRAALGPHSPRTLDITSPAQPLRYGSSVT 87 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E++T + A + L + GG + + Sbjct: 88 VE-PGGQVEVSTATHTSVAALVAATKAEIAQLTALLGRAGLVLGAGGID--AHRSPRPMF 144 Query: 112 DNERYQRT---LENFGYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 + RY+ + G ++ G + + D P +A A Sbjct: 145 ETPRYRAMRRVFDRRGPAGRRMMYSTAGLQICLDVGEADQLADRWATAHAIGPPLLAAFA 204 Query: 167 ASPYMQGTDTRFASSRPNIFSA----------FPDNGPMPWVSNWQQF------------ 204 + G T + S+R + A P+ +++W ++ Sbjct: 205 TAGRHAGRPTGWVSARMAAWLAIDPARTRAVWTPEQDDTDPIASWTEYVLAAPLLCLRGG 264 Query: 205 -------------EALFRCLSYTTMID----SIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 + L L ID + L +RP G +E+R +D Sbjct: 265 GSDWTTPDGVTFADWLAGALPQPPTIDDLDYHVSTLFPPVRPR---GYLELRYLDAQPGE 321 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF-QACRYGLEGVITDPHTGDRRP 306 S +V +A LL+E + + + R+ A R+GL G Sbjct: 322 SWSVPVA-----VVAALLSEPAITRAARSLVGAQAQRWIAAARHGLR------DDGLAVT 370 Query: 307 LTEDTLRLLEKIAPSAHKIGASSAI 331 + L + ++G A+ Sbjct: 371 AAD----LFDLALTVLPRLGLPPAL 391 >UniRef50_B2A6L2 Glutamate--cysteine ligase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6L2_NATTJ Length = 462 Score = 130 bits (326), Expect = 1e-28, Method: Composition-based stats. Identities = 66/406 (16%), Positives = 123/406 (30%), Gaps = 77/406 (18%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V+ G LS +K+ +K D +ES +EL T VC+ I +A Sbjct: 52 FGLEKENLRVDEQGNLALSPHPKE----FGDKLRNPYIKTDFSESQIELITPVCKSIEEA 107 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLE 121 +Q V T + P + Q RY +R + Sbjct: 108 YEFLGELQDFVSVRLT--GEYLWPQSNLPKLPEEEQ--IPIARYGKEGYKERKYRERLAK 163 Query: 122 NFGYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHF 161 +G + + G H + D + + L ++ Sbjct: 164 KYGK--KLQLLSGVHFNFSLKEEFLNKLYARLEHNKSYQEFKNDIYLKITKYLLKYRWLL 221 Query: 162 IALSAASPYMQGTDT------RFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTT 215 I L+ ASP ++ D F S R + + + + A + Sbjct: 222 IYLTGASPTLKTADNLGCYCKDFRSLRNSSCGYSNNEELYISYETIEDYVASLQASIDQG 281 Query: 216 MIDSIKDLHWDIRPSPHF-GT-----------VEVRVMDTPL----TLSHAVNMAGLIQA 259 I +I + + +R GT +E+R+ D +S + Sbjct: 282 KIQNINEFYSPVRIKGRGKGTLEELLKQGIQYLELRLFDLNPFDKNGISKEDLY--FTRL 339 Query: 260 TAHWLLTERPFKHQEKDYLLYKFNRFQ---ACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 +LL + F + + N Q A R E + G L E+ +++ Sbjct: 340 LITYLLVKADFTFGTMEQKMANTNHEQATLAER--PENIGVFDELGQWENLQEEATKIIN 397 Query: 317 KIAPSAHKI-GASSAIEAL----HRQVVS-GLNEAQLMRDFVADGG 356 ++ + G + + +V+ A + + V Sbjct: 398 ELEELIEVLGGETEYFSYVINTAREKVLKPEKTYALRIIEGVKQSS 443 >UniRef50_D1X937 Glutamate/cysteine ligase family protein n=11 Tax=Streptomyces RepID=D1X937_9ACTO Length = 456 Score = 130 bits (326), Expect = 1e-28, Method: Composition-based stats. Identities = 68/401 (16%), Positives = 114/401 (28%), Gaps = 76/401 (18%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSML---IDAVKNKITAGEVKHDITESMLELA 62 F P T+G+ELE + + DL L ++AV+ + + + LEL+ Sbjct: 32 FKTGPPRTVGVELEWLIHDRERPDLPVGQERLDRAVEAVRALPLSAALTFE-PGGQLELS 90 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTL-- 120 + + + +A V A L G G P+Q RY+ Sbjct: 91 SQPAGSLMECVDTTAADLAAVRAALDTAGLAPVGLGVDPWQ--APLRRLREPRYEAMEAA 148 Query: 121 -ENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF------VPHFIALSAASPYMQG 173 + G + V V +G++ L R+ +A A SP+ QG Sbjct: 149 LDRTGPAGRAMMCTSASVQVCLDAGEEEPGPLGYGRRWQLAHLLGAVLVAAFANSPFRQG 208 Query: 174 TDTRFASSRPNIFSAFP------------------------------DNGPMPWVSNWQQ 203 T + S+R ++++ V Sbjct: 209 RRTGWRSTRQSLWADLDPVRTLAPGSERAPREAWAAHVLDTTVLCIRREEGPWEVPEGLT 268 Query: 204 FEALFRCL-----SYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 F R + + L +RP G +E+R++D + + Sbjct: 269 FREWIRTGSPRPPVRADLDYHLTTLFPPVRPR---GHLELRMIDAQSGPDGWLVPLAVAT 325 Query: 259 ATAHWLLTERPFKHQEKD-------YLLYKFNRF-QACRYGLEGVITDPHTGDRRPLTED 310 A K + + A R GL DP L Sbjct: 326 ALFDDPEAAETVYRTLKPLAETSGAPAAPRNALWTTAAREGLA----DPE------LRAA 375 Query: 311 TLRLLEKIAPSAHKIGASSAIEALH-----RQVVSGLNEAQ 346 P+ ++GAS A+ R V G A Sbjct: 376 ATACFGAALPALERMGASGAVRDTVAAFTDRYVARGRCPAD 416 >UniRef50_B9LUZ8 Putative uncharacterized protein n=8 Tax=Halobacteriaceae RepID=B9LUZ8_HALLT Length = 519 Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats. Identities = 60/439 (13%), Positives = 111/439 (25%), Gaps = 103/439 (23%) Query: 14 LGIELEMQVV-NPPGYDLSQDSSMLIDAVKNKITAGE-VKHDITESMLELATDVCR-DIN 70 +G E E V + + S+ + V ++ + ++ E++T + Sbjct: 49 VGFEYEFYAVADGRWSEESRAGEYALMRVPRRLLELMGFEKELGLHNAEMSTSPQPLSDH 108 Query: 71 QAAGQFSAMQKVVLQA---ATDHHLEICGGG---THPFQKWQR---------------QE 109 Q + ++ + A A + + P + R Sbjct: 109 GLRAQLAEVRARLEAAENTAGVEGMRLVSDALWTIPPTGETARGYLTDSVDVDGVTVAVN 168 Query: 110 VCDNERYQRTLENFGYLIQ------------------QATVFGQHVHVGCASGDDAIYLL 151 + D RY G + ++ + H A D Sbjct: 169 MSDAVRYHAMANTGGDEHRGTVVKAPGVSLAADTVMPESLITSIQPHYQVAQADTLPQHF 228 Query: 152 HGLSRFVPHFIALSAASPY---------MQGTDT---RFASSRPNIFS------------ 187 R +AL SP+ G +R ++F Sbjct: 229 RYALRIAGPLLALGVNSPFFPPDLYDEGWDGERVLAEGATENRIHVFESVLNARTDEGKV 288 Query: 188 AFPDNG-----------------PMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRP- 229 FP PMP +F+ F +RP Sbjct: 289 RFPREFHDIETAVDRIVADETLIPMPEPEGTDRFDDEFATFRTKH-----GSYWRWVRPV 343 Query: 230 ------SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 S +E R + T+ ++ L ++ D+ + N Sbjct: 344 FEGASRSSANARIEFRPIPGQPTVRDSIAFQAAFAGLMQAL-PQQEHPVIGLDWETARDN 402 Query: 284 RFQACRYGLEGVITDPH-TGDRRPLTEDT-LRLLEKIAPSAHKIGASSA-----IEALHR 336 + A GL+ I G+R T+ LL+ G + L Sbjct: 403 FYAAVAGGLDAEIEWVGLDGERTTDTDALYADLLDHAEAGLRTAGCPDEEAAAWLAPLRW 462 Query: 337 QVVSGLNEAQLMRDFVADG 355 +V + A RD V + Sbjct: 463 RVANRTTPASWKRDRVRER 481 >UniRef50_C7NPM2 Glutamate--cysteine ligase GCS2 n=4 Tax=Halobacteriaceae RepID=C7NPM2_HALUD Length = 386 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 65/376 (17%), Positives = 112/376 (29%), Gaps = 38/376 (10%) Query: 10 EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDI 69 P IE+E V++ G + V+ + E +LE+ T C Sbjct: 23 APLRRSIEVEYWVIDDEGRLTDPG--------ELSDAGEGVEREFVEPLLEIKTTPCEST 74 Query: 70 NQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQ 129 +F VL+ A+DH + GT ER + G + Sbjct: 75 AALRTEFYERLDGVLRRASDHGKRLVPLGTP--MHDGEIADRPGERTRIQDRVVGSDFEY 132 Query: 130 ATVF-GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD--TRFAS--SRPN 184 G H+HV I L+ L P AL +SPY T S R Sbjct: 133 VRHCAGTHIHVE-QQPGHVIEQLNTLIALDPAL-ALVNSSPYFGHERLTTGARSQLYRRM 190 Query: 185 IFSAFPDNG-PMPWVSNWQQF-----EALFRCLSYTTMIDSIKD-----------LHWDI 227 + P G P+ + +++ ++ + + ++ + + Sbjct: 191 AYETLPHQGRLWPYAEDLEEWAKRLEHRYGEFVTQSIITGFDRERVESYFGPESAVWTPV 250 Query: 228 RPSPHFGTVEVRVMDT--PLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF 285 + F TVE R D P L + I + +F Sbjct: 251 QLRERFSTVEWRSPDAALPSQLLRLADDVASIVSRVTEAAVRIEGDRGGCAAGEIVLPKF 310 Query: 286 QACRYGLEGVITD-PHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNE 344 A ++ ITD + R + +E P A ++ A + + + L Sbjct: 311 DAVSEYVDAAITDGLDSSAVRSYLDRMGFSVEAYDPLAGEMDAPAELTESQAR-DRRLEY 369 Query: 345 AQLMRDFVADGGSLIG 360 A + V S+ Sbjct: 370 ADRLEADVRRVSSITA 385 >UniRef50_Q8TY80 Predicted metal-dependent hydrolase of the TIM-barrel fold n=1 Tax=Methanopyrus kandleri RepID=Q8TY80_METKA Length = 483 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 59/382 (15%), Positives = 122/382 (31%), Gaps = 77/382 (20%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGE------------ 49 + F +G+E E+ +++ L++ + +I + + Sbjct: 10 SVESFAERIEVKVGVEEELFLIDRD-GSLTRAADDVIVKAAELLESDSNLLEDCWRTVLG 68 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + + +E T ++ ++++ +AA + L++ HPF+ Sbjct: 69 LDPEPNPAQIEYLTQPLP-PDEVIEACEIGRELIKKAAEELGLQVMLESMHPFES-DPLP 126 Query: 110 VCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDD-------AIYLLHGLSRFVPHFI 162 + G H++V D + + + L +P I Sbjct: 127 IN----------------------GTHINVMVKLKDQPYMTPKQILVVYNWLWHNLPIII 164 Query: 163 ALSAASPYMQGTDTRFASSR--------PNIFSAFPDNGPMPWVSNWQ------------ 202 A +A +PY G AS R PN ++A P+++ Q Sbjct: 165 AATANTPYCCGGKNLAASCRLLKSRVLKPNYYAAIKRLEKRPYLTKTQYYGRLRYRLRLR 224 Query: 203 ---QFEALF------RCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 +FE R L T ++ D SP VEVRV+D ++ + ++ Sbjct: 225 KDTEFEERVVAHPDGRRLVDITPRGPASNVTGDENDSPTRNRVEVRVIDNQKSMKYLHDV 284 Query: 254 AGLIQAT-AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTL 312 LI L + + NR +A G+ G + L Sbjct: 285 VMLIVGLSLEALYIYEVEGKLPPNDPNHFDNRREAIEKGINATFV--INGREIDAEDALL 342 Query: 313 RLLEKIAPSAHKIGASSAIEAL 334 +++ ++ +G + L Sbjct: 343 KIISRVDKFLEHLG-LRFVSPL 363 >UniRef50_Q6ANW2 Glutathione synthetase n=1 Tax=Desulfotalea psychrophila RepID=GSHAB_DESPS Length = 779 Score = 128 bits (322), Expect = 3e-28, Method: Composition-based stats. Identities = 59/398 (14%), Positives = 111/398 (27%), Gaps = 78/398 (19%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G E E V+ G L+ L K + + D +ES +E+ T I ++ Sbjct: 24 FGFEKENIRVDSRGKLALTPHPREL----GEKTSHPYITTDFSESQIEIITPPLPSIAES 79 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---------CDNERYQ-RTLEN 122 G + +V + P + +++ + E Y+ + + Sbjct: 80 LGFLETLHDLVSIELK--DEYLWPQSAPPILPEREEDIPIAHFGGEFREQEEYRLQLAKI 137 Query: 123 FGYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFI 162 +G ++ G H ++ D + + R I Sbjct: 138 YGR--KRQMFSGIHFNISLPERFLELLHEEGKQEQPFAEFREDIYMKTVRNFLRHRWFLI 195 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAF-PDNGPMPWVS---------------------- 199 L ASP + S R + P Sbjct: 196 CLLGASPVI------HKSYRKHCIDMLSPFAKDAYHFPYATSIRNNICGYRNTQDFHLNY 249 Query: 200 -NWQQFEALFRCLSYTTMIDSIKDLHWDIRPSP-----HFGTVEVRVMDTPLTLSHAVN- 252 + + L ++ I++ + IR +E+R++D VN Sbjct: 250 STLTDYRESLQELVEKKVLRDIRENYAPIRIKTTTDPKRINHLEIRLLDLNPFFKTGVNP 309 Query: 253 -MAGLIQA-TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE-GVITDPHTGDRRPLTE 309 A +I + LL K+ N+ QA GL G I G+ + L + Sbjct: 310 LHAEIIHIFLIYCLLCPEETSFTSKEQETANRNQEQAATEGLNPGAIICDADGNEQRLDK 369 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL 347 L++I + + N+A Sbjct: 370 QLAHCLQEIQQTVSPHLPPEYRAGMEELERLVQNQASR 407 >UniRef50_D2B0V7 Glutamate/cysteine ligase n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2B0V7_STRRD Length = 408 Score = 128 bits (322), Expect = 4e-28, Method: Composition-based stats. Identities = 70/408 (17%), Positives = 114/408 (27%), Gaps = 66/408 (16%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 FH S +G+ELE V + D + + A+ V + LEL+ Sbjct: 25 FHGSAGDQVGVELEFLVFDRTSPDCHVPLARVAGALPPLPGGSRVTFE-PGGQLELS-GP 82 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFG- 124 + +A + +A A + L + G G P + +RQ RY+ E G Sbjct: 83 AGPLPEAIARLAADVDAARAALREAGLVLAGVGLDPIRPARRQLRLP--RYEAMAEFLGT 140 Query: 125 YLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 + V GD P A A SP G + S R Sbjct: 141 PYGSLMMCSTASIQVNLDLGDRPAVRWERAHLLGPVLTAAFANSPLSGGRPCGWMSGRQA 200 Query: 185 IFSAFPDNGPMP------WVSNWQQF-----------------------------EALFR 209 ++ P + W ++ A R Sbjct: 201 VWENLDRTRTAPVPATGDPAAAWAEYLLDARLMLVRENGDRCRTVRDGSTFRDWLAAPAR 260 Query: 210 CLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERP 269 L+ + + +RP G +E+R +D V +A A Sbjct: 261 PLTLADLAYHATTIFPPVRPR---GWLEIRYLDAQRPADWPVCVAV-THALVMDDRAAET 316 Query: 270 FKHQEKDYLLYKFNRF-QACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGAS 328 + Y + A R+GL L + + ++G S Sbjct: 317 AIAAAEPY----AGMWPGAARHGLA----------EPRLRKAAETCFRAALAALPRLGVS 362 Query: 329 S----AIEALHRQ-VVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 + + A + V +G A + D V G L E G Sbjct: 363 AGLIREVAAFADRHVTTGRPPAADLLDLV--KGPPRRLSAWLTEEGQG 408 >UniRef50_B4V5Z6 Glutamate-cysteine ligase n=10 Tax=Streptomyces RepID=B4V5Z6_9ACTO Length = 458 Score = 127 bits (320), Expect = 5e-28, Method: Composition-based stats. Identities = 60/402 (14%), Positives = 106/402 (26%), Gaps = 76/402 (18%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLI---DAVKNKITAGEVKHDITESMLELA 62 F P LG ELE V++ L L +A + + LEL+ Sbjct: 53 FKTGPPRILGAELEWLVLDAERPGLPLAPERLTAAHEAAGALPLHSRLTVE-PGGQLELS 111 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + ++ A V L + G G P + ++R + RY+ Sbjct: 112 SAPADSLSACVDGLQADLTAVRGVLHAQGLVLRGLGQDPRRPYRRLLT--DPRYEAMERY 169 Query: 123 F---GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRF------VPHFIALSAASPYMQG 173 G + V V +G + L R+ +A A SP + G Sbjct: 170 LDRAGPAGRAMMCASASVQVCVDAGHEEPGPLGHGRRWRLAHLLGAVLVAAFANSPAVDG 229 Query: 174 TDTRFASSRPNIFSAFPDN---GPMPWVSNWQQFEAL----------------------- 207 + +R ++ P + + Sbjct: 230 PYAGWRCARQGVWEDLDSGRSLAPPLDIEPRAAWTRHALDTRVMCVRAPEGAPEDTPWTV 289 Query: 208 -----FRCLSYTT---------MIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNM 253 FR T + + L +RP G +E+R++D + Sbjct: 290 PEGLTFRDWIRTGGPRPATAGDLEYHLTTLFPPVRPR---GHLELRMIDAQPGDDGWLVP 346 Query: 254 AGLIQATAHWLLTERPFKHQEK-------DYLLYKFNRFQ-ACRYGLEGVITDPHTGDRR 305 ++ A K + + ++ A R GL DP Sbjct: 347 VAVVHALFDDPEAAETAYRVSKALADSYGPHAAPRNPLWRSAARAGLA----DPE----- 397 Query: 306 PLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL 347 L A + ++GAS + + A Sbjct: 398 -LRSAATACFLAAAEALPRLGASDLVRDTVAEFTERHVLAGR 438 >UniRef50_B4VPR5 Glutamate-cysteine ligase family 2 n=1 Tax=Microcoleus chthonoplastes PCC 7420 RepID=B4VPR5_9CYAN Length = 432 Score = 127 bits (320), Expect = 5e-28, Method: Composition-based stats. Identities = 54/386 (13%), Positives = 113/386 (29%), Gaps = 74/386 (19%) Query: 12 FTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNK-----ITAGEVKHDITESMLELATDVC 66 +G+E E +V S + + + + + + + M+E+ T Sbjct: 6 RRIGLEQEFFLV-EETGKFSNRADEFLQNCRQEAETIGLNPDYFMPEWVKGMIEINTPPA 64 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 + A + ++ LQ HL + ++P + D Y + GY Sbjct: 65 HTPTELAIAYLKNLQLGLQVGKKMHLRLYPLSSYPLHLI--PVIRDKLSYHVQVRTVGYD 122 Query: 127 IQQAT--VFGQHVHVGCA-----------------SGDDAIYLLHGLSRFVPHFIALSAA 167 G H+H+ ++ I + + + IAL A Sbjct: 123 RFLNAGKCTGTHIHLEVPPGVIDSRVGVSYNSSAAEREELINIYNLATALDSALIALGRA 182 Query: 168 SPYMQGTDTRFASS--RPNIFSAF----------PDNGPMPWVSNWQ-----QFEALFRC 210 P+ +G T A R F G MP+ + + QFE + Sbjct: 183 CPFYEGEATGLAYHIVRYRGSDRFGWEGVYTHLQSVGGLMPYADSVEQLVELQFERYYAW 242 Query: 211 LSYTTMIDSIKDLH-----------WD-IRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 L+ + L W+ +R + GTVE+R +D+ + L+ Sbjct: 243 LTAMDNAGVERKLFTEGGGNLLKSGWNPVRLNA-LGTVELRGIDSN-YPDVIFTIMRLVY 300 Query: 259 ATAHWLLTERPFKHQEKDYLLYK-FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEK 317 A + E + ++ N + + P L Sbjct: 301 NAARRVRQEGITVRPAQGAHTFELRNDW----------LVVPEFDYLNG-----ELLFAA 345 Query: 318 IAPSAHKIGASSAIEALHRQVVSGLN 343 + ++ ++++ + + Sbjct: 346 VTEGVRSSKVTAYLDSILEFAIQDGS 371 >UniRef50_UPI0001C36E32 Glutathione synthase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C36E32 Length = 381 Score = 127 bits (319), Expect = 7e-28, Method: Composition-based stats. Identities = 55/325 (16%), Positives = 95/325 (29%), Gaps = 58/325 (17%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V+ G L D + D E+ +EL T VC I +A Sbjct: 11 KFGLERETLRVDSHG--------KLADTPHPFGNDEHITRDFCENQIELVTPVCSSIKEA 62 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEVCD-------NERYQRTLENFG 124 + + + D++ I P F + D Y+ LE Sbjct: 63 VASLAELDAKARKILDDNNESIWLYSNPPHFDSEADIPIADFTGDHSSKRAYREVLEQ-K 121 Query: 125 YLIQQATVFGQHVHVGCA---------SGDDA--------IYLLHGLSRFVPHFIALSAA 167 Y + G H + G D + L L + L+AA Sbjct: 122 YGKKLMLFSGIHFNFSFDEEFIRELNTDGQDFHSFRDSLYLRLYKQLMAHSWLLVLLTAA 181 Query: 168 SPYMQG---TD-------TRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMI 217 SPY D + ++S R + + P+ + + F + T + Sbjct: 182 SPYYDASLDKDGKSGIIMSEYSSLRNSSRGYWNKFLPILDHRSLRSFTGSIKKHIVTGSL 241 Query: 218 DSIKDLHWDIRPSPHF------------GTVEVRVMDTPLTLSHAVNM--AGLIQATAHW 263 S +L+ IR P +E+R+ D + +++ + Sbjct: 242 YSASELYLPIRLKPKGVNSLENLASNGVDHIELRMFDLDPSAPLGIDIRNLEFAHLLILY 301 Query: 264 LLTERPFKHQEKDYLLYKFNRFQAC 288 LL+ F + A Sbjct: 302 LLSLPDFDFTPELQEKAVAKHKNAA 326 >UniRef50_A6US46 Glutamate--cysteine ligase GCS2 n=1 Tax=Methanococcus vannielii SB RepID=A6US46_METVS Length = 367 Score = 126 bits (318), Expect = 9e-28, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 96/282 (34%), Gaps = 44/282 (15%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAG------EVKHDITESMLELATD-VC 66 +G E E + + + S ++I + KI + ++ + ++E Sbjct: 2 IGTEHEYSIND-FNFKAMPISDVIIKEITGKIQNEFFLDTIGISKELQKHVIEFKPKMPS 60 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQK------WQRQEVCDNERYQRTL 120 I K + + G G HP W E + Y R Sbjct: 61 GSIKDLEKMLYDGMKDFHSRTNNC-YNLMGLGMHPLLDLNGTAFWDHDEREVFDTYDRVF 119 Query: 121 E--NFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRF 178 G+L + V+V +S DD + + + +P+ +AL+A+SP ++G T++ Sbjct: 120 NLKQHGWL----NIQSIQVNVSYSSEDDMVLKHNKIRTMIPYLVALTASSPMVEGKLTKY 175 Query: 179 ASSRPNIF----SAFPD-NG--PMPWVSNWQQFEALFRCL-----------SYTTMIDSI 220 A +R + P+ G + +E L + ++S Sbjct: 176 ADNRLIYYKENQKEIPEITGKIIPEPLLKSSDYEDLLEKMYMELKEKEAQVLCQEWVNSR 235 Query: 221 KDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAH 262 + +R VE++ MD ++ + ++ LI Sbjct: 236 GLI---VRRERKC--VEIKAMDEQESIHADMAISALINCLIR 272 >UniRef50_D1REB2 Carboxylate-amine ligase-like protein n=1 Tax=Legionella longbeachae D-4968 RepID=D1REB2_LEGLO Length = 380 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 49/291 (16%), Positives = 98/291 (33%), Gaps = 21/291 (7%) Query: 11 PFTLGIELEMQVVNPPGYDLS----QDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 ++G+ELE V++ S + I + ++ + + +EL+T Sbjct: 5 ELSIGLELEANVIDIHTGKASLDFNNRAFQKISSYFLSQGYPAIQTEFDAATIELSTLPY 64 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYL 126 +++ A S + + G HP + + D+ +L Sbjct: 65 HNLDLAFQSLSGCLNAANDFLSQQGYLLLLLGLHPGRGRDELVMTDSSYCLASLPLMAEQ 124 Query: 127 IQQATVFGQHVHV--GCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPN 184 +++ G D I L H L ++ ++ +SP +T + S R Sbjct: 125 GGPLFYCSYQINLGIGVNDIDYLIPLCHWLQVYMWPCSVITQSSPVFANKNTNYKSYRVR 184 Query: 185 IFSAF--PDNGPMPW-VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGT------ 235 + + GP+P + N +F+ L ++ +DI P T Sbjct: 185 LNDSLSGSRTGPLPLDIRNLSEFKHYCNHLPDKADTLRQYNVWYDILPKAIDPTHPSAGY 244 Query: 236 -VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF 285 +E+RV DT + QA ++ ++ LL NR+ Sbjct: 245 RIEIRVADTTA----LSKLYVFTQAMLLSFMSILHKLRTKES-LLLPENRW 290 >UniRef50_C7MXH6 Gamma-glutamylcysteine synthetase n=2 Tax=Actinomycetales RepID=C7MXH6_SACVD Length = 428 Score = 123 bits (309), Expect = 1e-26, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 90/346 (26%), Gaps = 70/346 (20%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKN--------------KITAGEVK 51 F P LG+ELE V + L + L DA+ Sbjct: 47 FKHGPPRLLGVELEYTVHDAVDPGLPLSRTRLADALGPYAPRTLVPDSPEQPLPAGSTFT 106 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + E++T A V L + G PF+ +R Sbjct: 107 LE-PGGQAEISTAPHSSFRALCEAADADLAYVADLLAATGLRLGSRGIDPFRPPKRLLHT 165 Query: 112 DNERYQRTLENF-----GYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 RY F G + + V V + + P +AL A Sbjct: 166 P--RYAAMERRFAPAGTGGITMMCSTAALQVCVDTGQPHELPHRWAAAHALGPVLLALFA 223 Query: 167 ASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMID-------- 218 S + G DT AS+R + EA R + T ++ Sbjct: 224 NSRWHAGVDTGCASARWLAVMDTDTCRTAAQRTGGDPAEAWARRVLDTPLLLLRRDDGPW 283 Query: 219 -------------------------------SIKDLHWDIRPSPHFGTVEVRVMDTPLTL 247 + L +RP G +E+R +D Sbjct: 284 DAPSELTFADWIDGGGAATSLPRPTLADLDYHLTTLFTPVRPH---GYLELRYLDAQPLE 340 Query: 248 SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGL 292 S +A L + + + +R+ A R+GL Sbjct: 341 SWEHPVA-----LLAALFSRQSLVESVLEVCEPVADRWSEAARHGL 381 >UniRef50_A4FGC2 Glutamate-cysteine ligase n=3 Tax=Actinomycetales RepID=A4FGC2_SACEN Length = 412 Score = 123 bits (309), Expect = 1e-26, Method: Composition-based stats. Identities = 58/348 (16%), Positives = 94/348 (27%), Gaps = 68/348 (19%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--------------AGEVK 51 F P GIELE V + D +LI A+ + Sbjct: 33 FKTGPPRLHGIELEWTVHHDDDPSRPLDPEVLISALGPHAPPSLVPGSPHRPLPNGSSLT 92 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E+++ + +A + + L + GT P++ +R V Sbjct: 93 VE-PGGQVEVSSLPSPSVRSLFDVVAADADHLRRLLRPSGLSLGEQGTDPWRHPRR--VL 149 Query: 112 DNERYQRT---LENFGYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 RY + G + G V + L P +A A Sbjct: 150 QVPRYAAMESAFDRIGIDGRLMMCSTAGVQVCLDAGEPHRIAPRWAALHALGPVMLATFA 209 Query: 167 ASPYMQGTDTRFASSRPNIFSAF--PDNGP----MPWVSNWQQ----------------- 203 SP + G DT + S+R P P + W + Sbjct: 210 NSPKLFGHDTGWLSTRTRAVLRTDPPRTRPGPVSPDPATGWARRMLDTALVCLRRDGVDW 269 Query: 204 -------FEALFRCLSYTTMI-----DSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 F + + +R G +EVR +D + Sbjct: 270 TVPGGISFAEWISGALAGPPTMDDLDYHMSTVFPPVR---ARGYLEVRYLDAQPGDDWML 326 Query: 252 NMAGLIQATAHWLLTERPFKHQEKDYLLYKF-NRF-QACRYGLEGVIT 297 A LI L E E L + R+ A R+GL + Sbjct: 327 PAAALI------ALFEAESTVDEVLRLTARTPGRWMHAARHGLADPVL 368 >UniRef50_B0KFE7 Methyltransferase small n=1 Tax=Pseudomonas putida GB-1 RepID=B0KFE7_PSEPG Length = 461 Score = 122 bits (306), Expect = 3e-26, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 62/182 (34%), Gaps = 18/182 (9%) Query: 199 SNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQ 258 ++W +E L T + + D W IRPS + TVE+R+ D L + +A L Sbjct: 284 ADWPDYERYLDLLLRTGVRPDV-DCWWAIRPSRRYPTVELRIADGCPRLEDGLCIAALFY 342 Query: 259 ATAHWLLT--ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLE 316 + + + + + N ++A RYG +G D + E +L Sbjct: 343 EMVTHCIEVGREINLLTRETHWVTQENLWRAMRYGRDGRFIDLSSLAPLSAREWLFQLQA 402 Query: 317 KIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVAD--------GGSLIGLVKKHCEI 368 + + I + ++++ + A +L +V Sbjct: 403 RFELADVHIDQAV-------RILTTGSSADQQLKVYDQAVTRGLAHELALQDVVDLLVNQ 455 Query: 369 WA 370 A Sbjct: 456 TA 457 >UniRef50_C7HWJ1 Putative uncharacterized protein n=1 Tax=Anaerococcus vaginalis ATCC 51170 RepID=C7HWJ1_9FIRM Length = 442 Score = 120 bits (301), Expect = 9e-26, Method: Composition-based stats. Identities = 45/406 (11%), Positives = 106/406 (26%), Gaps = 74/406 (18%) Query: 12 FTLGIELEMQVVNPP---------------------GYDLSQDSSMLIDAVKNKITAGEV 50 F +G+E+E V++ S + + + V Sbjct: 28 FKIGLEMEHFVIDKDELFSYDYFGEKGVGSTLKDLKDMGFSVTNEEDGYILGLRKEDIAV 87 Query: 51 KHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 + ELA D ++IN + + ++ + + + G HP K + Sbjct: 88 NLE-PAGQFELAIDAKKNINDLDKSYKKIMGEIVPIFDEKNQYLETLGYHPKSKIMDLNI 146 Query: 111 CDNERYQRTLENF----GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 +RY+ + F G + +S D + P L Sbjct: 147 IPKDRYKYMQKYFTEFGGKYALNMMRGTASVQSAIDFSSEKDFKKKFFVANALSPFMYKL 206 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFP--DNGPM-PWVSNWQQFEALFRCLSYTTMI---- 217 + QG + R I+ G +E + T +I Sbjct: 207 YDNAYIFQGKPYENKNLRQEIWEYCDKNRTGVYDFAFDEDMSYEKYAEKILNTDIIFVHE 266 Query: 218 --------------------------DSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 ++ + D+R + +E+R+ D + + Sbjct: 267 DGQDVYKGDTKFEKIMDKDFSDEMIFHALSIVFPDVRVKKY---IEIRMPDAVSYPYN-L 322 Query: 252 NMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + LI+ + L + + Y + + A +G + + + + E Sbjct: 323 SFPALIKGLFYNEENLNKLREDFKNMTYDSCQKLKMDAKEHGFDAKY------EGKTICE 376 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + + + + + + + + Sbjct: 377 WIKYFISLAKDGLDE-NEKTYLSCIEKLIDEKETLKDKFEKIYKED 421 >UniRef50_D1VG95 Glutamate/cysteine ligase family protein n=1 Tax=Frankia sp. EuI1c RepID=D1VG95_9ACTO Length = 442 Score = 119 bits (298), Expect = 2e-25, Method: Composition-based stats. Identities = 72/415 (17%), Positives = 113/415 (27%), Gaps = 76/415 (18%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAV----KNKITAGEVKHDITESMLELA 62 + +GIE E VV+ D A+ + + + EL+ Sbjct: 37 ADTAVGQVGIETEWFVVDRHSPDSPVAPERTRAALAGCGPDLPGGSRITFE-PGGQFELS 95 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 SA V D L + G G P + +R + RY E Sbjct: 96 GPPLALPAALRA-MSADLTAVRLRLADDGLLLAGLGADPLRAPRRLLT--HSRYAAMEEF 152 Query: 123 FGYLI------QQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 F + V++ P +A+ A+SP + G T Sbjct: 153 FQTGGFPAGPLMMCSTAALQVNLEAGPRSGWEDRWRLAHTLGPVLVAMFASSPVLAGRPT 212 Query: 177 RFASSRPNIFSAFPDNGPMPWVSNWQQF------EALFRCLSYTTMI--DSIKDLHWDIR 228 S+R I+S P QF R L ++ D + +R Sbjct: 213 GQVSTRQGIWSDIDATRTTPVADAGTQFTTGGPAAEWARYLLDARLMLVRDGDDRYLPVR 272 Query: 229 -------------PSPHFGTV--------------------EVRVMDTPLTLSHAVNMAG 255 P P TV E+R +D V + Sbjct: 273 DGSTFADWVAGAGPVPRRPTVADLAYHASTVFPPVRPRGWLELRYLDAQSPALWPVAVT- 331 Query: 256 LIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPLTEDTLRL 314 A LL + +D R+ A GL + L LR Sbjct: 332 ----VAAALLDDPRAADTARDACAGVAGRWAEAAALGLA----------QPDLRTAALRC 377 Query: 315 LEKIAPSAHKIGASSAIEALHRQ-----VVSGLNEAQLMRDFVADGGSLIGLVKK 364 + + +A ++G S A+ A V G + A GG+ L+ Sbjct: 378 VMAVVEAAGRLGLSPALTAAVADFADTFVRRGQSPADAALASWRAGGASAVLLDA 432 >UniRef50_B8CWC8 Glutamate--cysteine ligase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CWC8_HALOH Length = 443 Score = 117 bits (294), Expect = 6e-25, Method: Composition-based stats. Identities = 52/410 (12%), Positives = 104/410 (25%), Gaps = 85/410 (20%) Query: 6 FHVSE----PFTLGIELEMQVVNPPGYDLSQ-----DSSMLIDAVKNKITAGE------- 49 F E F LG+ELE ++N ++ + E Sbjct: 14 FKSGEKSPNNFKLGLELEHFILNKDDLTAVSYYEDKGVEDILKELVRVNWEPEYEGAYLI 73 Query: 50 --------VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP 101 + + LEL+ I + + + + I G HP Sbjct: 74 KLIKDKMTITLE-PGGQLELSLAPVSTIKEIDLLYQSFLDDIFPILLKWDKVIVNLGYHP 132 Query: 102 FQKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSR 156 + + RY+ E F G V + DD + Sbjct: 133 ESGIKNIPLLPKNRYKYMYEYFKNRGRYAHNMMKGTASIQVSLDYQDEDDYRKKIISSYY 192 Query: 157 FVPHFIALSAASPYMQGT---DTRFASSRPNIFSAF--PDNGPM-PWVSNWQQFEALFRC 210 P + P+ +G D AS R I+ G + + ++ Sbjct: 193 LSPIIYCIFDNGPFFEGKLWDDP--ASIRSIIWDNCDNDRCGLIKGIFKDEFGYKDYASY 250 Query: 211 LSYTTMI---------------------------------DS-IKDLHWDIRPSPHFGTV 236 + I + + D+R + + Sbjct: 251 ILNCPPIIIKKDGNLVFTGDTSARELLSSFISSKISKEELMHLLTMVFPDVRTKKY---L 307 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEG 294 E+R+ D+ + L + + L K + D +Y + + R+G + Sbjct: 308 EIRIGDSLPYPY-FLGFVALWKGLLYNKENLDYLYSKAGQVDKGIYFEYKNRIQRHGYKA 366 Query: 295 VITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNE 344 D + +L + +++L + +G Sbjct: 367 -FIDGE-----SVISRFRKLKGMASIGLTSS-ERKYLDSLDYIIENGPTP 409 >UniRef50_A1A2R1 Possible glutamate--cysteine ligase n=18 Tax=Bifidobacterium RepID=A1A2R1_BIFAA Length = 432 Score = 117 bits (293), Expect = 7e-25, Method: Composition-based stats. Identities = 35/234 (14%), Positives = 65/234 (27%), Gaps = 31/234 (13%) Query: 14 LGIELEMQVVN-----PPGYDLSQDSSMLIDAVKNKIT-----------------AGEVK 51 G+E+E V+ Y S L + ++ V Sbjct: 48 FGVEIEHLPVHNSDDTAVTYYESNGIEALFNRIRPYYDENKEYWENGRLVGLARDGISVS 107 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + LE + + + A + A ++ V + + G P + V Sbjct: 108 LE-PGGQLETSIGILHKPEELATLYGAFRREVDPILEELGFRLVNYGYQPKSSYADIPVN 166 Query: 112 DNERYQRTLENFGYLIQQ---ATVF--GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 +RY+ G + Q V + S DAI L + P Sbjct: 167 PKDRYKAMTAYLGRVGQFGPCMMRCSASTQVSIDYVSEQDAIAKLRLGTVIGPILAWFFR 226 Query: 167 ASPYMQGTDTRFASSRPNIFSAFP---DNGPMPWVSNWQQFEALFRCLSYTTMI 217 +PY +G + + R ++ N +E + T M+ Sbjct: 227 NTPYFEGGENPYPPLRQRMWDYLDFQRTNVIPGLFDPRFGWEDYAVDVLSTPMM 280 >UniRef50_B4WP90 Putative uncharacterized protein n=3 Tax=Cyanobacteria RepID=B4WP90_9SYNE Length = 382 Score = 117 bits (293), Expect = 8e-25, Method: Composition-based stats. Identities = 46/312 (14%), Positives = 98/312 (31%), Gaps = 36/312 (11%) Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E+ T V I++ + + + A HP + Q + Y++ Sbjct: 87 IEIRTTVHDSIDETLAELIESFERLRIEAKKSGFSPALISFHP-HRSQFIPIPPLNNYEQ 145 Query: 119 TLEN----FGYLIQQATVFGQHVHVGCA--SGDDAIYLLHGLSRFVPHFIALSAASPYMQ 172 G +++ S I + L+ + P I S +SP+ Q Sbjct: 146 QRRQKSPEMQTAHIPMLTQGPDLNLSAEGLSPTQLIDIGRKLTYYSPFIIPFSYSSPFYQ 205 Query: 173 GTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPH 232 G + S+R F G P A+ T +IDS L R Sbjct: 206 GREWSGLSART-----FYRTGARP--------AAMVFVEQATDLIDSTPSLTQIARIPAE 252 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 G +E + D+ + G + A L+ ++ + + + + R+G Sbjct: 253 VGRIEFKAFDSCGDFE----LYGSLLALLKGLVLDQSLQGRATIPEAKQHQH--SARFGF 306 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + +L ++ + + L ++ + A M + Sbjct: 307 ADE----------TIYNQAQAILAAVSQVELEAEEHDRLTKLQERLTQRRSPANGMIEAY 356 Query: 353 ADGGSLIGLVKK 364 G S++ ++++ Sbjct: 357 RQGESIVNILQR 368 >UniRef50_D2RU12 Glutamate--cysteine ligase GCS2 n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RU12_9EURY Length = 365 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 59/389 (15%), Positives = 103/389 (26%), Gaps = 69/389 (17%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQ 75 IE+E VV+ G + + V + + + E + EL T C I + Sbjct: 5 IEVEYWVVDTDGELTEPGA---LAEVSERT-----EREFVEPLFELKTPPCETIGELRAT 56 Query: 76 FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR--TLENFGYLIQQATVF 133 F+ + VL A + GT + + R Q+ E+F Y Sbjct: 57 FAEQLEEVLSTAAAEEKRLVPLGTPINCGAIDRRPSERGRIQKEVLGEDFAYAK---YCA 113 Query: 134 GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD----TRFASSRPNIFSAF 189 G H+HV + D + L L + +SPY+ G R R + Sbjct: 114 GTHIHVEKRNVADQLNTLIALDAALALV----NSSPYLDGERVANSARAHCYRKKCYGDL 169 Query: 190 PDNGPMPWVSN---------WQQFEALFRCLSYTT----MIDS----IKDLHWDIRPSPH 232 P +G + + ++E R I+ + IR Sbjct: 170 PKHGQLWHYVDTVGEWCRRLEDRYEEFKRAALEEGIDEVAIEDNFSTDNVVWTPIRLRDE 229 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 TVE R D A LL + + ++ Sbjct: 230 MPTVEWRSPDA---------------ALPSQLLRLADDLEMVMERVHNTNVEVESVSDSR 274 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIE----------ALHRQVVSGL 342 I ++ + ++ Sbjct: 275 HAGHVTDDGIRLPTFETACEFANSAIDDGLESADVVGYLDRMGFSVDDYHPISTRIDGRQ 334 Query: 343 ----NEAQLMRDFVADGGSLIGLVKKHCE 367 +A+ +R A+ L V + E Sbjct: 335 YVTRGDARDLRLEYANR--LEEDVDELVE 361 >UniRef50_A4T5Z6 Glutamate--cysteine ligase, GCS2 n=28 Tax=Actinomycetales RepID=A4T5Z6_MYCGI Length = 448 Score = 115 bits (288), Expect = 3e-24, Method: Composition-based stats. Identities = 47/348 (13%), Positives = 93/348 (26%), Gaps = 59/348 (16%) Query: 7 HVSEPFTLGIELE---MQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 P +G+E+E + +P + + +I + V + +EL+ Sbjct: 58 KDVPPGPVGLEIEAHCYDLSDPFRRPGWDELTAVIADLPRLPGGSLVTVE-PGGAVELSG 116 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF 123 A + V+ L + G P + R V RY F Sbjct: 117 PPATGTADAVSAMVTDRAVLRDVFAGAGLGLVLLGADPLRPAGR--VNPGSRYAAMERFF 174 Query: 124 GY-------LIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDT 176 + V++ + P IA++A SP + G T Sbjct: 175 AESGTPEAGAAMMTSTASVQVNLEAGHRAGWADRVRLAHALGPTMIAIAANSPVLAGKFT 234 Query: 177 RFASSRPNIFSAFPDNGPMPWV--------SNWQQFEALFRCLSY--------------- 213 + S+R ++S P + S+W ++ + Sbjct: 235 GWHSTRQLVWSQLDSARCGPILGVDGDDPASDWARYALRAPVMLVHTPEAVPVTQWVPFA 294 Query: 214 ----------------TTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 + + L +RP G +EVR +D+ + L Sbjct: 295 DWADGRVLLDDRRPTLADLDYHLTTLFPPVRPR---GFLEVRYLDSVPDAVWPAVVFTLS 351 Query: 258 QATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRR 305 + + + E + +A + GL+ Sbjct: 352 TLLDDPVAADVAAEATEPVATSWD----RAAQLGLDDRRLHTAAVRCV 395 >UniRef50_B9ZBA6 Glutamate--cysteine ligase GCS2 n=1 Tax=Natrialba magadii ATCC 43099 RepID=B9ZBA6_NATMA Length = 358 Score = 114 bits (286), Expect = 5e-24, Method: Composition-based stats. Identities = 60/365 (16%), Positives = 112/365 (30%), Gaps = 42/365 (11%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQ 75 IE+E VV+ G + I + + + EL T C I + Sbjct: 5 IEVEYWVVDNEGALTAPGELADISEFTE--------TEFVDCLFELKTPPCETIPELRRT 56 Query: 76 FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF-G 134 F + VL A + + GT + E+ +ER + + G A G Sbjct: 57 FVEQFRTVLDRAAELDKALVPLGTP--INSESIELRADERGEIQRQLLGTNFDYAKHCAG 114 Query: 135 QHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD----TRFASSRPNIFSAFP 190 H+H + D + L L +AL +SPY QG R R ++ P Sbjct: 115 THIHFEKRNVTDQLNTLIALDP----ALALCNSSPYFQGEYVASSARAHIYRRQCYADLP 170 Query: 191 DNGPMP-WVSNWQQ--------FEALFRCLSYTTM----IDSIKD----LHWDIRPSPHF 233 ++G + +V + F+ + + ID + +R Sbjct: 171 NHGQLWNYVDTVAEWHRRLEHCFDEFTERAAANGISRAQIDEHFTVDDAVWAPVRLRDEM 230 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLT---ERPFKHQEKDYLLYKFNRFQACRY 290 TVE R D L SH + + + + L + F + Sbjct: 231 PTVEWRSPDATL-PSHVLQLVSDMDSIMEALHHTNVRIEGETTSHGTDDIVLPTFDSLHE 289 Query: 291 GLEGVITDPHTGDR-RPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMR 349 ++ + D + + ++ P ++ + ++ L L A + Sbjct: 290 YVDAAMIDGLDSEAVVDYLDRLGFQTDRYDPLTTEVDSGESVS-LEDARELRLQYADRLE 348 Query: 350 DFVAD 354 + Sbjct: 349 RDLDR 353 >UniRef50_B6W6Y7 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W6Y7_9FIRM Length = 413 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 41/406 (10%), Positives = 110/406 (27%), Gaps = 78/406 (19%) Query: 14 LGIELEMQVVNPP-----------------------GYDLSQDSSMLIDAVKNKITAGEV 50 +G+E+E V++ G++++ + I ++ A + Sbjct: 1 MGLEMEHFVIDKKELFSYDYFGKKGVGASLKELNQMGFEITNEEEGYILGLRQDDIAVNL 60 Query: 51 KHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV 110 + ELA D ++I + + ++ + + + G HP K + Sbjct: 61 EP---AGQFELAIDAKKNIKDLDESYKKIMTEIIPIFEEKNQYLETLGYHPKSKIMDLNI 117 Query: 111 CDNERYQRTLENF----GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIAL 164 +RY+ + F G + DD + +L Sbjct: 118 IPKDRYKYMQKYFTDFAGKYALNMMRGTASVQTAIDYCDEDDFKKKFFVANALSAFMYSL 177 Query: 165 SAASPYMQGTDTRFASSRPNIFSAFP--DNGPM-PWVSNWQQFEALFRCLSYTTMI---- 217 + +G + + R I+ G +E + T +I Sbjct: 178 YDNAYIFEGEVYKDRNLRQEIWEHCDKNRTGVYDFAFDEDMGYEKYAEKILDTDIIFVHE 237 Query: 218 --------------------------DSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAV 251 ++ + D+R + +E+R+ D + Sbjct: 238 NGKDVYKADTKFEKIMDEDFSDEMIFHALSIVFPDVRAKKY---LEIRMPDAVPYPYNI- 293 Query: 252 NMAGLIQATAH--WLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTE 309 + L++ + L + ++ Y + ++ ++GL+ + + Sbjct: 294 SFPALLKGLFYNEENLNKLREDFKDMTYETCQKLKYDTKKHGLDAKY------QGKSVCT 347 Query: 310 DTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADG 355 + + S + + + + + Sbjct: 348 WIKYFISLSKNALSD-EEKSYLTCIEKLMDEKETLRDKFEKLYKED 392 >UniRef50_C3JX20 Glutamate--cysteine ligase family protein n=5 Tax=Nocardiaceae RepID=C3JX20_RHOER Length = 407 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 60/393 (15%), Positives = 101/393 (25%), Gaps = 81/393 (20%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--------------AGEVK 51 F P +G ELE PG + ++ L A+ V Sbjct: 29 FKQGPPRLVGAELEWLTSQVPGGE-RPSAATLAKALGRHAPTSIDPDSPAVPLPRGSLVT 87 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +EL++ + ++ + + +EI + R + Sbjct: 88 VE-PGGQIELSSAPRTSARELCDCLDEDRRTLETLLASYSIEISSAAADVARPPSR--IL 144 Query: 112 DNERYQRTLENF---GYLIQQATVFGQHVHVGCA---SGDDAIYLLHGLSRFVPHFIALS 165 RY F G V V S + L P IA Sbjct: 145 RLPRYCAMESRFAGIGPYGTLMMCNTAAVQVSVDAGGSPESIAQRWRLLGDMGPALIAAF 204 Query: 166 AASPYMQGTDTR-FASSRPNIFSAFP--DNGPMPWVSNWQQFEALFRCLSYTTMIDSIKD 222 A SP +QG +AS R + +P V ++ + + + + D Sbjct: 205 ACSPRLQGVPRGDWASQRMRTWLELDSWRTVAVPEVQDYAGWALDVPLM----CVRNEGD 260 Query: 223 LHWDIR----------------------------------PSPHFGTVEVRVMDTPLTLS 248 R P G +EVR +D Sbjct: 261 DWTAPRGATFGDWIDGALDAEIGRRPVWADLDYHLSTLFPPVRAVGHLEVRYIDAQPGDL 320 Query: 249 HAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQ-ACRYGLEGVITDPHTGDRRPL 307 V +A LL+ + D R++ A YGL+ L Sbjct: 321 WRVPVAA-----IDALLSGPAVMREASDAAASTAGRWRDAAEYGLDD----------VEL 365 Query: 308 TEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS 340 L+ A A + ++A + Sbjct: 366 RSAATSLMSLAASYAPEPQFVRLLDAAAERCCR 398 >UniRef50_D2RUA3 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RUA3_9EURY Length = 363 Score = 111 bits (277), Expect = 5e-23, Method: Composition-based stats. Identities = 59/341 (17%), Positives = 109/341 (31%), Gaps = 50/341 (14%) Query: 16 IELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQ 75 +E+E V++ G +S S L+D + ++ + E MLE+ T C + + + Sbjct: 5 LEVEYWVIDDDGDLVSPGS--LLD------YSEQIDPEFVEPMLEIKTTPCSSMAELREE 56 Query: 76 FSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF-G 134 F + + ++ AA + + T D G A V G Sbjct: 57 FLGLIEEIVDAARERDKRLVPLATPLHAAPSEIPYRDKRGTDLQRRIVGPAFDDARVCAG 116 Query: 135 QHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD----TRFASSRPNIFSAFP 190 H+H ++ D + +L L AL +S + +G R R + + P Sbjct: 117 THMHFEQSNVADQLNMLTALDP----AFALVNSSSHYRGEHILECARPFLYRRSCYEPCP 172 Query: 191 DNG-PMPWVSNWQQFEALFRCL------------SYTTMIDSI----KDLHWDIRPSPHF 233 D G P+V + ++E + D + ++ Sbjct: 173 DQGQLWPYVDSAAEWEEELETAYDCFRERALERGVDSAAFDDEFAPYDAVWTPVQLRKAM 232 Query: 234 GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLE 293 TVE R DT L S + +A +++ + N E Sbjct: 233 PTVEWRSPDTAL-PSQVLRLAETVRSLVSRADARGTTIGDGDPTDTHGNN---------E 282 Query: 294 GVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 G +T P +T+ I G + ++ L Sbjct: 283 GSVTLPLFDSVETVTDAA------IHDGLENAGVRNYLQNL 317 >UniRef50_B1CBH9 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBH9_9FIRM Length = 416 Score = 108 bits (270), Expect = 3e-22, Method: Composition-based stats. Identities = 50/414 (12%), Positives = 107/414 (25%), Gaps = 96/414 (23%) Query: 6 FHVS----EPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDI------- 54 F + +LG+ELE +V + K+ + + +I Sbjct: 15 FKSGIKEEKDKSLGLELEHFIVRADTMESVDYYEENGIRDILKLLSPYFEKEIYKDGNLI 74 Query: 55 ------------TESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPF 102 S LE++ D +++ + + ++ G P Sbjct: 75 GLVKDKSNITLEPASQLEISIGPFIDTLDILEEYNYFLLKIKPILKKFNYKMIYAGYQPK 134 Query: 103 QKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRF 157 K + +RY+ L+ F G + V V S +D + Sbjct: 135 SKVDELNLIPKKRYEYMLDYFSKVGSHGKNMMKGSASAQVSVDYFSEEDFKNKFRLANIL 194 Query: 158 VPHFIALSAASPYMQGTDTRFASSRPNIFSAF-PDNGPM--------PWVSNWQQF---- 204 P ++ + +G R I++ P+ + + ++ Sbjct: 195 SPVISFMTDNTNIFEGKHYDKNCVRIGIWNDVDPERSMIVKDALNKDFGFKEYSEYILNS 254 Query: 205 ---------------------EALFRCLSYTTMIDSI-KDLHWDIRPSPHFGTVEVRVMD 242 + I+ + D+R VE+R+ D Sbjct: 255 PAILIEDKNGNSVYTRNKKIKDIYCDSELNKKDIEHLISMFFPDVRLK---NYVEIRMAD 311 Query: 243 TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNR------------FQACRY 290 + + ++ A +I+ +E + K N + A Y Sbjct: 312 CLP-IDYVLSYASIIKGI---FYSEEAISLLLDKFKYIKDNDVIKAKGEVVNKGYDAKVY 367 Query: 291 GLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNE 344 G E + + L L+E + + + V Sbjct: 368 GFE-------------IKDLLLSLIELAKDNLC-HEEKDRVSLFYDLVKREKTL 407 >UniRef50_D2RSM6 Putative uncharacterized protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RSM6_9EURY Length = 513 Score = 108 bits (270), Expect = 4e-22, Method: Composition-based stats. Identities = 57/464 (12%), Positives = 108/464 (23%), Gaps = 113/464 (24%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCR 67 S F LG+ELE V+ G + V + + G + ++ +E T+ Sbjct: 41 DSPGFGLGLELEAYAVDEAGR---------LARVPDAVFEGRCERELGRHNVEFNTEPTP 91 Query: 68 ----DINQAAGQFSAMQKVVLQAATDHHLEICGGGT---HPFQKWQR------------- 107 I A Q + A LEI P + + Sbjct: 92 FDGSGIAVQAAQLERRVRKAQSDAEADGLEIVLDAMWTRPPPEGAREYLAATTEREGVAL 151 Query: 108 -QEVCDNERYQRT-------------------LENFGYLIQQATVFGQHVHVGCASGDDA 147 + + ++ RY E F L+ ++ HV + Sbjct: 152 AENMTESARYYAIDNDVLARTGGEIALSVPGVEETFPSLLFESLTSSVQPHVQIPDVEAF 211 Query: 148 IYLLHGLSRFVPHFIALSAASPY-------MQGTD-------------TRFASSRPNIFS 187 + + +AL+ SP + D R +F Sbjct: 212 PRYYNTALGTLGPVLALATNSPLLPPDLYDFEKRDESAGPTDPYALLEATHHELRIPVFE 271 Query: 188 A-----FPDNGPMPWVS-NWQQFEALFRCLSYTTMIDSI--------------------K 221 + + + L + + Sbjct: 272 QSVNRAWEKVRVPRRIERTTDAIDRLVADQTCAPFLREWLADGDREEFADRFWELDHKRG 331 Query: 222 DLHWDIR------PSPHFG----TVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFK 271 +R P +E R + T T++ V + L+ L+ Sbjct: 332 TYWRWLRTVVGGQPVAEGDRWSVRLEYRPLPTQPTVAETVGLQCLVAGLLRGLV-GAAHP 390 Query: 272 HQEKDYLLYKFNRFQACRYGLEGVITD-PHTGDRRPLTEDT-LRLLEKIAPSAHKIGASS 329 + + + A GLE + GDR + L + G S Sbjct: 391 IATLEREAAAASFYDAVANGLEADLAWITADGDRTSDRDVIYDELFAFAHRGLREQGVSD 450 Query: 330 -----AIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEI 368 + + ++ + V D Sbjct: 451 GTIETYLGPFEARWRERTTPSRWKLERVRDELDAGERFADAVHE 494 >UniRef50_D2RRB5 Glutamate--cysteine ligase GCS2 n=2 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRB5_9EURY Length = 371 Score = 106 bits (266), Expect = 1e-21, Method: Composition-based stats. Identities = 66/373 (17%), Positives = 122/373 (32%), Gaps = 52/373 (13%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 L +ELE V+ L+ + ++D + ++ + + MLE+ TD C D+ + Sbjct: 3 LSLELEYWTVD-DTGALA-SARPVLDRI------DDLHAESADPMLEVVTDPCIDVPELR 54 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVF 133 + + + V++ A + + GT D R + + G AT Sbjct: 55 EEVTVRLREVIEVAREEGRHLVPLGTP--LGAASVSTSDGPRTRIQRQVLGEAFDNATHC 112 Query: 134 -GQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTD----TRFASSRPNIFSA 188 G H+HV G + L+ L+ P F AL A+S Y QG + R R + Sbjct: 113 AGTHLHVDQIEGAET-DQLNLLTALDPAF-ALVASSSYDQGHNVAACARSHVYRRACYGD 170 Query: 189 FPDNG-PMPWVSNWQQ--------FEALFRCLSYTTMIDSIKD--------LHWDIRPSP 231 P G P+V + + F+ R + + D + +R Sbjct: 171 HPRLGQLWPYVEDVAEWDDRIDATFDRFRRQALGLGVEPATFDTHFTPEDSIWAPVRLRE 230 Query: 232 HFGTVEVRVMD---------TPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKF 282 FGT+E R D + +N+ + + + Sbjct: 231 KFGTIEWRAPDIALPGQILRLVEDVRDILNLVADRRVEIGGRAGVTASTVSVPAFDRLQQ 290 Query: 283 NRFQACRYGLEGVITD-------PHTGDRRPLTEDTLRLLEKIAPSAH--KIGASSAIEA 333 A GLE T RP++ + + A ++ + +E Sbjct: 291 YVSLAIDRGLEAPAVRRYLETMGFDTTAYRPISAELGNTSQMSRGRAQWLRLRYADRLER 350 Query: 334 LHRQVVSGLNEAQ 346 + + A+ Sbjct: 351 EVEALTVDQSPAR 363 >UniRef50_D1N7M9 Glutathione synthase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7M9_9BACT Length = 740 Score = 106 bits (264), Expect = 2e-21, Method: Composition-based stats. Identities = 57/414 (13%), Positives = 111/414 (26%), Gaps = 91/414 (21%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G+E E +L++ + + + K D ES +EL T C Sbjct: 31 RIGVERESLRC-TASGELAETAHP--ETLGRKDDNPFFTADWAESQIELKTPPCESPLAC 87 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ-------EVCDNERYQRTLENFGY 125 + + L+ H + T + +N R ++ E + Sbjct: 88 HRFLETLTDIALRELAARHELLWPLSTPCLLPEPDRIACARFENAAENLRRRKLREKYP- 146 Query: 126 LIQQATVFGQHVHVGCAS----------------GDDAIYLLHGLSRFVPHFIALSAASP 169 ++ + G H + + + L R + + L ASP Sbjct: 147 -VEMLLLSGIHYNFSFDDGLLRRIAGDGELQAVREGCYLKTIRNLYRMLWFAVGLLGASP 205 Query: 170 YMQG-------TDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKD 222 G A R + S+ + + +I + + Sbjct: 206 ASAGDREIQVSIRNSPAGYRTLSSARLD-------YSSVRAYRESVDRCLKAGLIATEHE 258 Query: 223 LHWDIRP---------SPHFGTVEVRVMDTPL-------TLSHAVNMAGLIQATAHWLLT 266 L+ IR +P +E+R+ D + + L Sbjct: 259 LYTPIRLRFAGAATDDAPEIDRLELRIPDLNPFEKCGISPVDMEFLRLLFFHSL---LTD 315 Query: 267 ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG 326 E + D YG P + +LLE++A +A Sbjct: 316 ETELEKFADDADAV-------AEYGFS-----PDQSRK------AGKLLERLAETAR--N 355 Query: 327 ASSAIEALHRQVVSGL-----NEAQLMRDFVADGGSLIGLVK-----KHCEIWA 370 S + + Q L + A+ +R+ + L + E W Sbjct: 356 ISVELPDVLEQAGKRLHHPQLSYARRIRETGERSPEWLRLAESYRDQALAEAWR 409 >UniRef50_Q0RAS7 Glutamate--cysteine ligase GSHA (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) n=3 Tax=Frankia RepID=Q0RAS7_FRAAA Length = 523 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 66/208 (31%), Gaps = 25/208 (12%) Query: 2 PLPDFHVSEPFTLGIELEMQVVNPP----------GYDLSQDSSMLIDAVKNK--ITAGE 49 P P + ++GIE E VV+ S LI Sbjct: 88 PEPSVGIGT--SVGIETEWFVVDTRVVHQPVPPERTRRALGRISGLITGAAGPVLPGGSR 145 Query: 50 VKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQE 109 + + LEL+ + A +A +V A + L I G G P + RQ Sbjct: 146 LTFE-PGGQLELSGPP-AGLAAAVQSTAADLHLVRAALAEDGLAIVGMGVDPLRAGVRQ- 202 Query: 110 VCDNERYQRTLENFGYLIQQA------TVFGQHVHVGCAS-GDDAIYLLHGLSRFVPHFI 162 RY E+F + + V++ + A P Sbjct: 203 -TTASRYAAMEEHFRTGGGTSGEVMMRSTASVQVNLDLGTTPAQAAERFRLAHAVGPVLT 261 Query: 163 ALSAASPYMQGTDTRFASSRPNIFSAFP 190 A+ AASP + G T + S+R ++S Sbjct: 262 AMFAASPALAGRRTGWRSTRQAVWSGID 289 >UniRef50_C1DH93 Glutamate-cysteine ligase-like protein n=1 Tax=Azotobacter vinelandii DJ RepID=C1DH93_AZOVD Length = 392 Score = 102 bits (254), Expect = 3e-20, Method: Composition-based stats. Identities = 42/380 (11%), Positives = 92/380 (24%), Gaps = 64/380 (16%) Query: 10 EPFTLGIELEMQVVNPPGYDL----------SQDSSMLIDAVKNKITAGEVKHDITESM- 58 GIE E +V+ G + L+ + D+ Sbjct: 18 PAVHYGIEFEYLLVDTRGPQAGRLRDIHALDVPRLAELLADKPGLGDPELAEGDLGIRNG 77 Query: 59 -----------------------LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEIC 95 +E+ T + A +++ + L + Sbjct: 78 YWYLEGDERFDLEGRLVGFVAKGVEIRTPPRPSVAVAIDCLLDIERQLAARLERDGLGLA 137 Query: 96 GGGTHPFQKW--QRQEVCDNERYQRTLEN-FGYLIQQATVFGQHVHVGCASGDDA--IYL 150 G P + + + ER R + + + +G +++ + Sbjct: 138 IAGFDPLRTRYGYQPPLNAFERRLRAGDREYEGMELSMLTYGPDLNLSLPDWSTRRNLDA 197 Query: 151 LHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRC 210 L+ + P+ + S +SPY G + P V + E Sbjct: 198 ARKLNYYAPYIVPFSFSSPYCAGQP-----WHGWSRRTWLRCEQRPAVKLFLGLEEYAEQ 252 Query: 211 LSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPF 270 + ++ R + G +E + D ++ +A L Sbjct: 253 AERSPLLR-------PARLAREAGRIEFKAFDAMPSVE---LLAACCHLLTGICLANNLR 302 Query: 271 KHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSA 330 E + +A + + L++ G Sbjct: 303 GRSETPDVAL---YRRAALHAFDDAEIRNGARAALYAA---AEALDRAGNETAVAG---- 352 Query: 331 IEALHRQVVSGLNEAQLMRD 350 + L R + S A + Sbjct: 353 LAPLARLLSSRSTPAHDLLA 372 >UniRef50_D2MHE8 Putative uncharacterized protein n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHE8_9BACT Length = 268 Score = 99 bits (248), Expect = 1e-19, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 47/166 (28%), Gaps = 18/166 (10%) Query: 218 DSIKDLHWDIRPSPH-----FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKH 272 + RP +E R + + T V + L ++ Sbjct: 85 LHQGTVWRWNRPVYDPKNGGHLRIEFRSLPSGPTPLDMVANTAFLVGMVEGLSSQMEELL 144 Query: 273 QEKDYLLYKFNRFQACRYGLEGVITDPH----TGDRRPLTEDTLRLLEKIAPSAHKIG-- 326 + N ++ ++GL+ V+ P + P+ + L LL ++G Sbjct: 145 PSFPFEYAHHNFYRGAQFGLDAVLLWPSIQYPSPREVPVCDLALDLLPVAERGLAQLGVE 204 Query: 327 ---ASSAIEALHRQVVSGLNEAQLMRDFVA----DGGSLIGLVKKH 365 S E + ++ A+ R + +V Sbjct: 205 AGEISRMSEVIRTRIERRCTGARWQRRMLDHLEQQSSRRQAVVALL 250 >UniRef50_C4RDQ5 Glutamate-cysteine ligase GCS2 n=2 Tax=Micromonospora RepID=C4RDQ5_9ACTO Length = 537 Score = 99.6 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 55/200 (27%), Gaps = 22/200 (11%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKIT--------------AGEVK 51 F P G+ELE V + D L A+ V Sbjct: 16 FKTGPPTRTGVELEWTVHDAADPARPVDRERLRAALGPHSPTTIDDSSPAAPLRHGSTVT 75 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E++T + +A V L + G P++ + Sbjct: 76 VE-PGGQIEISTAPRSSVAALIEATNADIAQVTDLLRRAGLLLGRTGIDPWRLPR--PTV 132 Query: 112 DNERYQRT---LENFGYLIQQAT--VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSA 166 D RY+ + G + G V + + P +A A Sbjct: 133 DTPRYRAMRCVFDRGGPAGRTMMYSTAGLQVCLDAGEPAHVAARWAAVHAVGPPLLAAFA 192 Query: 167 ASPYMQGTDTRFASSRPNIF 186 + G T +AS+R + Sbjct: 193 TADRHAGRRTGWASARMAAW 212 >UniRef50_Q1WVP8 Glutamate--cysteine ligase n=12 Tax=Lactobacillus RepID=Q1WVP8_LACS1 Length = 452 Score = 98.1 bits (243), Expect = 5e-19, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 107/328 (32%), Gaps = 58/328 (17%) Query: 4 PDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELAT 63 + FT+G+E+EMQ V+ LSQ+ A+ ++ T + +D E+M E+ T Sbjct: 13 EAVAKTSDFTMGLEIEMQRVD-DTGHLSQEPYP--SAIGDEKTNPWITNDFLETMSEVVT 69 Query: 64 DVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP-------FQKWQRQEVCDNERY 116 A A+ V+ A + P + + + Sbjct: 70 PAASHALDAMHYLYAINNVLRSALAP-GELLWPLSMPPKLPKDKSTIQTAKMGPVKEAYF 128 Query: 117 QRTLENFGYLIQQATVFGQHVHVGCAS----------GDDA---IYLLHGL--------S 155 + ++ G+ + T G H+++ + I + + L Sbjct: 129 KEFIKRHGF--SKGTPCGAHINLSIDDHIIDLVLKNFPERFKNRIEVQNYLYTVLAQGFM 186 Query: 156 RFVPHFIALSAASP-----YMQGTDT---RFASSRPNIFS-AFPDNGPMPWVSNWQQFEA 206 R+ L ASP Y D S R + + +G + Q++ Sbjct: 187 RYRWLITYLFGASPIAEANYFDKEDELPHPIRSIRQSSYGFGTRFSGC---FVDVQKYVK 243 Query: 207 LFRCLSYTTMIDSIKDLHWDIR----------PSPHFGTVEVRVMDTPLTLSHAVNMAGL 256 ++ + D H +R P +E+R++D + S V L Sbjct: 244 RIEEGLKQGVLIADHDFHSPVRFKGTKDFRDLPKKGVQYLELRMLDLDPSSSVGVRTGTL 303 Query: 257 --IQATAHWLLTERPFKHQEKDYLLYKF 282 I+ + + + K + D +L K Sbjct: 304 RFIRLLSSYFIMHPALKADDVDQVLGKA 331 >UniRef50_C3R5G2 Glutathione biosynthesis gshAB n=1 Tax=Bacteroides dorei 5_1_36/D4 RepID=C3R5G2_9BACE Length = 764 Score = 97.7 bits (242), Expect = 6e-19, Method: Composition-based stats. Identities = 55/370 (14%), Positives = 104/370 (28%), Gaps = 64/370 (17%) Query: 14 LGIELEMQVVNPP-GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E VN L+ +K + D +ES +E+ T + +A Sbjct: 22 FGLEKENVRVNQDGTLALTPHP----AVFGDKGKHPYITTDFSESQVEMITPPLPSVGEA 77 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW-QRQEVC-------DNERYQR-TLENF 123 G + VV + + P K Q + D E Y++ + Sbjct: 78 LGFMETLHDVVTENIG--DELLWPQSLPPVLKENQEIPIAHYSGEFKDKEYYRQKLAGTY 135 Query: 124 GYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHFIA 163 G ++ + G H + + ++ ++ FI Sbjct: 136 GK--ERQLISGIHFNFSFSEKLMDVLLKSGVCGSSMEEVRETVYFRVVRNFLKYRWLFIW 193 Query: 164 LSAASPYMQ------GTDTR---------FASSRPNIFSAFPDNGPMPWVSNWQQFEALF 208 L SP + T S R + S+ + + Sbjct: 194 LYGESPLAEETLNVISLKTGEKQPMKCGVSLSLRTSPLGYRNREEFFIDYSSLEAYNMSI 253 Query: 209 RCLSYTTMIDSIKDLHWDIRPS------PHFGTVEVRVMDTPLTLSHAVNMAGLIQA--- 259 L ID +L+ +R +EVR++D V + + + Sbjct: 254 DKLIRENRIDGPHELYLPVRIKFLEKDNGSPSYIEVRIVDLDPFTKSGVCASAIYFSHLL 313 Query: 260 TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIA 319 + LL E E++ N+ A YG + + + +LE + Sbjct: 314 LVYSLLKEENGSLTEEELQRATRNQDMASCYGRDEKKE--LKCCSTTVQQKATSILEDME 371 Query: 320 PSAHKIGASS 329 + G Sbjct: 372 RILSEYGVLD 381 >UniRef50_C7QH01 Glutamate--cysteine ligase GCS2 n=1 Tax=Catenulispora acidiphila DSM 44928 RepID=C7QH01_CATAD Length = 366 Score = 97.3 bits (241), Expect = 8e-19, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 90/315 (28%), Gaps = 79/315 (25%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDA---VKNKITAGEVKHDITESMLELA 62 F P +G+ELE + + D S ++ A + +G + + EL+ Sbjct: 21 FKTGPPSRVGVELEWFPRDARHPEHLPDRSRVLRAFADAADLPLSGTLTME-PGGQWELS 79 Query: 63 TDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGG---THPFQKWQRQEVCDNERYQRT 119 + + + ++ ++A + LE+ G G HP + D+ RY Sbjct: 80 SAPADSVRELIAVTDRDLTLLRRSAAEAGLELVGMGREHGHP-----PSRLVDHPRYVAM 134 Query: 120 ---LENFGYLIQQAT--VFGQHVHVGC----ASGDDAIYLLHGLSRFVPHFIALSAASPY 170 + + V++ +D R P A+ Sbjct: 135 EHFFDRDNGSGRVMMCSTASIQVNLDAGTEHDGPEDFRRRWRLAHRLSPVLTAVF----- 189 Query: 171 MQGTDTRFASSRPNIFSAF-PDNGPMPWVSNWQ---QFEAL------------------- 207 S RP +++A P P + + + Sbjct: 190 -------CRSDRPAVWAAIDPGRTVAPPLDSPDPRSAYAQYALDAKLMCVQRADDGPWTA 242 Query: 208 -----FRCLSYTTMID--------------SIKDLHWDIRPSPHFGTVEVRVMDTPLTLS 248 FR T ++ + L +RP G +E+RV+D Sbjct: 243 PAGLTFREWIKTGALEPGEDRAPTLEDLTYHLTTLFPPVRPR---GHLELRVLDALPGDL 299 Query: 249 HAVNMAGLIQATAHW 263 V L+ A H Sbjct: 300 WRVP-TALVTALFHD 313 >UniRef50_Q8XK30 Glutathione synthetase n=11 Tax=Bacteria RepID=GSHAB_CLOPE Length = 778 Score = 95.4 bits (236), Expect = 3e-18, Method: Composition-based stats. Identities = 54/368 (14%), Positives = 104/368 (28%), Gaps = 61/368 (16%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E V +L+ A ++ +K D +ES LE+ T VC + + Sbjct: 26 FGLEKENVRV-TESGNLALTPHP--KAFGDREKNAYIKTDFSESQLEMVTPVCNTLEEVY 82 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN--ERYQRTLEN---FGYLIQ 128 + KVV + + P + + R + Y + Sbjct: 83 SFICNLNKVVSLEIMKNGEFLWPQSNPPILPREEEIPIAKLSNREDELYRENLSYKYGKK 142 Query: 129 QATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFIALSAAS 168 + + G H + D + + ++ I L+ AS Sbjct: 143 KQVISGIHYNFSFKEEFIKLLYKELKVEKDFREFKDDIYLRMARNFQKYHWLLIYLTGAS 202 Query: 169 PYMQ--------------GTDTRF----ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRC 210 P G D+ + S R + + ++ +++ + + Sbjct: 203 PVFHESYIEEIKEEGEKLGEDSYYIKDDTSLRNSSYGYKNKKDYYVSYNSIEEYASDIKN 262 Query: 211 LSYTTMIDSIKDLHWDIR-------------PSPHFGTVEVRVMDTPLTLSHAVNMAGLI 257 L I SIK+ + IR +EVR++D V+ L Sbjct: 263 LVKDKEIQSIKEYYNPIRLKSLGSEDMLESLLHKGIDYLEVRLLDLDPLSIQGVSKETLY 322 Query: 258 --QATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLL 315 + L + + KD + N G G L + +L Sbjct: 323 LLHLFMIYTLLKENKEITYKDQEEFFKNHDMVALKGRNEEAVIYENGVPVLLKDKGREIL 382 Query: 316 EKIAPSAH 323 ++ Sbjct: 383 SEMDEIVE 390 >UniRef50_Q127I4 Glutamate--cysteine ligase n=18 Tax=cellular organisms RepID=Q127I4_POLSJ Length = 537 Score = 95.0 bits (235), Expect = 4e-18, Method: Composition-based stats. Identities = 68/390 (17%), Positives = 113/390 (28%), Gaps = 80/390 (20%) Query: 15 GIELEMQVVNPPGY-DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE E P G L+ + L A+ T + D +ES +EL T +D Sbjct: 30 GIEKESLRAQPGGGLALTPHPAALGSAL----THPSITTDFSESQIELVTGAHQDAEATL 85 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLEN 122 + + + + + D E+ + P + + R+ R + Sbjct: 86 KELTQIHQFTYRVMQDLGDEMLWVSSMPCGLPTDETI-PIARFGSSNVGRAKSVYRMGLS 144 Query: 123 FGYLIQQATVFGQHVHVGCASG--DDAIYLLHGLSRFVPHFIALSAASP-----YMQGT- 174 Y + T+ G H + + L+ R + L ASP ++ G Sbjct: 145 HRYGRRMQTISGIHYNWSLPEVTSEQYFALIRNFRRHAFLLLYLFGASPAVCSSFVAGRQ 204 Query: 175 --------DTRFA----SSRP--------------NIFSAFPDNG---------PMPWVS 199 T + S R +++ G P P Sbjct: 205 HELQQLADHTMYMPHGTSLRMGRLGYQSDAQASLAVSYNSLEGYGASLQDALTRPYPAYE 264 Query: 200 NW------QQFEALFRCLSYT-----TMIDSIKDLHWDIRPSPHFGT-----VEVRVMDT 243 + L L I + + RP +EVR+MD Sbjct: 265 AVGIRNPGGDYNQLATTLLQIENEFYGTIRPKRVIFPGERPLHALRERGVEYIEVRLMDL 324 Query: 244 PLTLSHAVNMAG---LIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPH 300 + + L H LLT+ P + L + A R G E + Sbjct: 325 DPFVPVGITAQTMRFLDVFLLHCLLTDSPPDTPAEIAALARNQHRAAAR-GREPGLLLER 383 Query: 301 TGDRRPLTEDTLRLLEKIAPSAHKIGASSA 330 G L E ++ + AP A + A A Sbjct: 384 DGREVTLAEWGTAVVAECAPIAAALDALHA 413 >UniRef50_B7BHE3 Glutamate--cysteine ligase (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BHE3_9PORP Length = 424 Score = 93.8 bits (232), Expect = 9e-18, Method: Composition-based stats. Identities = 54/370 (14%), Positives = 103/370 (27%), Gaps = 64/370 (17%) Query: 14 LGIELEMQVVNPP-GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E VN L+ +K + D +ES +E+ T + +A Sbjct: 22 FGLEKENVRVNQDGTLALTPHP----AVFGDKGKHPYITTDFSESQVEMITPPLPSVGEA 77 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW-QRQEVC-------DNERYQR-TLENF 123 G + VV + + P K Q + D E Y++ + Sbjct: 78 LGFMETLHDVVTENIG--DELLWPQSLPPVLKENQEIPIAHYSGEFKDKEYYRQKLAGTY 135 Query: 124 GYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHFIA 163 G ++ + G H + + ++ ++ FI Sbjct: 136 GK--ERQLISGIHFNFSFSEKLMDILLKSGVCGNSMEEVRETVYFRVVRNFLKYRWLFIW 193 Query: 164 LSAASPYMQ------GTDTR---------FASSRPNIFSAFPDNGPMPWVSNWQQFEALF 208 L SP + T S R + S+ + + Sbjct: 194 LYGESPLAEETLNVISLKTGEKQPMKCGVSLSLRTSPLGYRNREEFFIDYSSLEAYNMSI 253 Query: 209 RCLSYTTMIDSIKDLHWDIRPS------PHFGTVEVRVMDTPLTLSHAVNMAGLIQA--- 259 L ID +L+ +R +EVR++D V + + + Sbjct: 254 DKLIRENRIDGPHELYLPVRIKFLEKDNGSPSYIEVRIVDLDPFTKSGVCASAIYFSHLL 313 Query: 260 TAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIA 319 + LL E E++ + A YG + + + +LE + Sbjct: 314 LVYSLLKEEKGSLTEEELQRATRIQDMASCYGRDEKKE--LKCCSITVQQKATSILEDME 371 Query: 320 PSAHKIGASS 329 + G Sbjct: 372 RILSEYGVLD 381 >UniRef50_Q8YYX1 All0721 protein n=4 Tax=Nostocaceae RepID=Q8YYX1_ANASP Length = 372 Score = 91.5 bits (226), Expect = 5e-17, Method: Composition-based stats. Identities = 40/311 (12%), Positives = 91/311 (29%), Gaps = 36/311 (11%) Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP--FQKWQRQEVCDNERY 116 +E+ T + I A + S ++ A + HP + + E Sbjct: 82 IEIRTTIHSSIQNAITELSDSFNLLCGVAAEFGFSPVLTSFHPYKTSFAPNPPLNEYELK 141 Query: 117 QRTLE-NFGYLIQQATVFGQHVHVGCAS--GDDAIYLLHGLSRFVPHFIALSAASPYMQG 173 Q + + +G +++ A + I + L+ + P+ + S +SP+ G Sbjct: 142 QLQADPDDQTANIYMVTYGPDLNISVADLPHERVIDIGKKLTYYSPYIVPFSYSSPFYNG 201 Query: 174 TDTRFASSRPNIFSAFPDNGP-MPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPH 232 T S R I G + Q+ E L + S+ + R Sbjct: 202 TLWEGLSVRTFI-----RTGKRPATLIFVQEKEQLIN------SVPSLTKI---ARLPAE 247 Query: 233 FGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGL 292 G +E + D+ S + L++ + + + ++G Sbjct: 248 VGRIEFKAFDSCDDFSIYAALLALLKGLVIDKSLPGRATVPDAELHKL------SAKFGF 301 Query: 293 EGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFV 352 + +L+ + + L + ++ + + Sbjct: 302 GDENIFTN----------ATNILQAAEFALKDDPDVDLLAPLKVMLTKRRTKSHTLIELF 351 Query: 353 ADGGSLIGLVK 363 GS+ +K Sbjct: 352 KHLGSIEETLK 362 >UniRef50_C7P329 Putative uncharacterized protein n=2 Tax=Halobacteriaceae RepID=C7P329_HALMD Length = 571 Score = 90.7 bits (224), Expect = 7e-17, Method: Composition-based stats. Identities = 52/431 (12%), Positives = 99/431 (22%), Gaps = 100/431 (23%) Query: 38 IDAVKNKITAGEVKHDITESMLELATDV----CRDINQAAGQFSAMQKVVLQAATDHHLE 93 + + I ++ E+ TD + K L AA + Sbjct: 127 LAELPESIFGTAAAKELGVHNAEINTDPDVLGPTGLAVQTTSIEMRIKKALDAARQENRT 186 Query: 94 ICGGGTHPFQKWQ-----------------RQEVCDNERYQRTLEN-------------- 122 + + + + + RY Sbjct: 187 LVLDAMWTIPPAEGSVSYLSDVEERDGIVFARNMRQDPRYVALDNEALAHAGGEIDFSVP 246 Query: 123 -----FGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQG---- 173 F ++ ++ H+ D + R + +AL+A SP + Sbjct: 247 GASHSFPTILFESLTSSVQPHLQIPDSDAFPAYYNAAIRTLGPMVALTANSPLLPADMYD 306 Query: 174 ---------TDTRFASSRPNIFSAF------PDNGPMPWVSNWQQ----------FEALF 208 DT R F P + + F Sbjct: 307 AVEDPRALLEDT-HHELRIAAFEQSVNTSENPKVRVPSDIETTTEVVDRVVEDDLFAPFL 365 Query: 209 RCLSYTTMIDSIKDLHW-----------DIR------PSPHFG-----TVEVRVMDTPLT 246 R + D +W +R P G +E R + T T Sbjct: 366 REWIEEGSRSGLHDTYWEFDHKRGTYWRWLRCVIGGDPVDGAGDERSLRIEYRPIPTQPT 425 Query: 247 LSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRP 306 ++ + + L L+ E + + + + A R G + +R Sbjct: 426 VADTIAVQVLTAGLLRGLVV-ADHPLAELPWQDAEASFYSAAREGPGADLAWVTADGQRT 484 Query: 307 LTEDT--LRLLEKIAPSAHKIG-----ASSAIEALHRQVVSGLNEAQLMRDFVADGGSLI 359 D + E + + R+ G ++ D V + S Sbjct: 485 TDHDAIYDEVFEYARRGLASQDVPESQIDEMLAPIERRRTLGTTPSRWKLDRVGEYLSEH 544 Query: 360 GLVKKHCEIWA 370 L CE Sbjct: 545 DLPDAICEAQR 555 >UniRef50_Q2RLA4 Putative uncharacterized protein n=1 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RLA4_MOOTA Length = 328 Score = 90.7 bits (224), Expect = 8e-17, Method: Composition-based stats. Identities = 41/274 (14%), Positives = 71/274 (25%), Gaps = 69/274 (25%) Query: 10 EPFTLGIELEMQVV--NPPGYDLSQDSSMLI---------DAVKNKITAGEVKHDITESM 58 P G+E E+ + + P + L+ N +++ + Sbjct: 2 TPLRFGLEEEVFITEPDKPTLQSLYYLARLLWLDPGYYYTHTACNFNRGKDLRWGLMSG- 60 Query: 59 LELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQR 118 +E++T V D ++ + I G H F + + Sbjct: 61 IEISTGVFPDTGDLVADLRRRRRELAAVCQGL---IVPVG-HLFDQVAPTNI-------- 108 Query: 119 TLENFGYLIQQATVFGQHVHV-GCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTR 177 G HVHV G + L F+P L SP Sbjct: 109 --------------CGMHVHVSGFPDRE---RAYRNLVYFLPLLALLVINSPIAGSRRYG 151 Query: 178 FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHW-DIRPSPHFGTV 236 S R W + + + + D+ S GT+ Sbjct: 152 -QSYR------------------WAE-------AFAIGPLREDRLYRFQDLIESKRLGTL 185 Query: 237 EVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPF 270 E+RV D L + I+A + Sbjct: 186 EIRVFDPVWDLERIRILLECIRAVLEAGVDYPGD 219 >UniRef50_Q18FX4 Putative uncharacterized protein n=2 Tax=Halobacteriaceae RepID=Q18FX4_HALWD Length = 536 Score = 89.6 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 54/464 (11%), Positives = 111/464 (23%), Gaps = 126/464 (27%) Query: 8 VSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV-- 65 S+ +G+ELE +V+ L+ + + ++ +E T Sbjct: 49 DSDHVAVGLELEAYIVDSKT-QLAPAPETVFELNG-------CSPELGVHNVEFHTTPDA 100 Query: 66 --------CRDINQAAGQFSAMQKVVLQAATDHHLEIC---------GGGTHPFQKWQRQ 108 + A + ++ + D + GT + + Sbjct: 101 IGAESDNGGSGFRRQASELHHIRDSIRSHIDDVDRTLVYDSLWTIPPETGTDAYLRAGTT 160 Query: 109 E--------VCDNERYQRTLENFGYLIQ------------------QATVFGQHVHVGCA 142 E V RY E ++ H+ Sbjct: 161 EHGIFFAENVRPIPRYIALNEMIRERSGGTVELGLPGLDTAPSMLVESLATSIQPHLQIP 220 Query: 143 SGDDAIYLLHGLSRFVPHFIALSAASPY-----MQGTDTRFA---------SSRPNIFSA 188 DA L+ +R + ++L+A SP+ G A R IF Sbjct: 221 DPRDAAAYLNAATRTMGPLLSLTANSPFLPADCYAGVSAEVAADRLARTPHELRIPIFER 280 Query: 189 FPDNG-----PMPWVSNWQQFEALF---RCLSYTTMIDSI------------------KD 222 D G + L ++ +++ Sbjct: 281 AVDTGAEKCRVPADADDIFDVIDRIVTDPTLVASSTLETPIPASDADPCDLSVFPTKRGT 340 Query: 223 LHWDIRPS-----PHFG-------------------TVEVRVMDTPLTLSHAVNMAGLIQ 258 +RP P G +E R + T T+ + + L+ Sbjct: 341 YWRWVRPVFCGQTPRGGAETTAVPTDHTGHTNHASVRIEYRPLPTQPTIRDTIGVQALVT 400 Query: 259 ATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDT--LRLLE 316 H +T + + + + + A G + + +D L Sbjct: 401 GVLHGAVT-TNHPLETLTWDDAEESFYAAVADGPTATLAWVDDSGTHQMDQDAIYADLFS 459 Query: 317 KIAPSAHKIGASSA-----IEALHRQVVSG-LNEAQLMRDFVAD 354 + S + + + ++ RD V Sbjct: 460 LARRGLSALDVSDETIEWALTPIESRRDGPYQTPSEWKRDRVEQ 503 >UniRef50_UPI0000382CE6 COG3572: Gamma-glutamylcysteine synthetase n=1 Tax=Magnetospirillum magnetotacticum MS-1 RepID=UPI0000382CE6 Length = 282 Score = 89.6 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 47/159 (29%), Gaps = 17/159 (10%) Query: 27 GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQA 86 G++ D+ +I + A ++ EL+ D++ + A V +A Sbjct: 70 GWEPILDAGNIIGLAGQEGGAISIEP---GGQFELSGAPLPDVHATVAELDAHLAAVKRA 126 Query: 87 ATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENF---GYLIQQAT--VFGQHVHVGC 141 A + G P + + RY+ G L V+V Sbjct: 127 AEPLGIGFLDLGMSPKWTREATPLMPKSRYRIMRNYMPKVGKLGLDMMLRTDTVQVNVDF 186 Query: 142 ASGDDAIYLLHGLSRFVPHFIALSAAS----PYMQGTDT 176 AS D + + P A S P G T Sbjct: 187 ASEADMVRTMRVRLALHPE-----ATSCRQLPLHDGRPT 220 >UniRef50_D2SD82 Carboxylate-amine ligase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD82_9ACTO Length = 122 Score = 89.6 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 50/116 (43%), Gaps = 1/116 (0%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 T+G+E E +V+P L+ ++++ A+ V +I + LE +T VC Sbjct: 8 GTEPGVTVGVEEEFHLVDPDTLVLTPGTTVVAAALAGDA-GEHVHPEIVSTQLETSTGVC 66 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLEN 122 + + + SA + AA L + THPF W+ Q + RY+ + Sbjct: 67 ATLPELRTELSATRAEAAAAAARDGLALLAASTHPFGTWREQRLTAAPRYRDRAQR 122 >UniRef50_Q97IV1 Glutamate--cysteine ligase n=2 Tax=Clostridium RepID=GSH1_CLOAB Length = 481 Score = 88.4 bits (218), Expect = 3e-16, Method: Composition-based stats. Identities = 58/411 (14%), Positives = 110/411 (26%), Gaps = 104/411 (25%) Query: 14 LGIELEMQVVN-PPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E Q VN L+ +K + D +ES +E+ T + + Sbjct: 26 FGVERESQRVNYSGDLALTPHP----SVFGDKFENPRITTDFSESQIEMITPPLKSAEEV 81 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHP-FQKWQRQEV-----CDNERYQRTLEN---F 123 + + V A + P K + V ++ R ++ N Sbjct: 82 YKALNDINNEVKNALK--GELLWPLSMPPRLPKEEDIPVAQFPDTEDGRQKQIYRNGLAL 139 Query: 124 GYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHFIA 163 Y + + G H + + + L R+ I Sbjct: 140 RYGKKMQMISGIHYNFSFSDKMIDFIYRQLRIEKTKRQFIDEMYFSLTRNFLRYHWILIY 199 Query: 164 LSAASPYMQGT-------------------------DTRFA-SSRPNIFSAFPDNGP--M 195 L ASP T R+A S R + F + Sbjct: 200 LFGASPICDSTYNSVIFKELEKIEKCCPHCAGKIKNFNRYATSLRVSRFGYSDTDEKKYT 259 Query: 196 PWVSNWQQFEALFRCLSYTTM---------------------IDSIKDLHWDIRPSPHFG 234 + ++ +++E + + T + S + + IR + Sbjct: 260 VYFNSLREYETKIKKMMETESNKYSKLGIYKDGVQIQLNGNLLQSESEFYAPIRFKRNIK 319 Query: 235 ---------------TVEVRVMDTPL--TLSHAVNMAGLIQATAHWLLTERPFKHQEKDY 277 +E+R++D + +V +Q + L E E+ Sbjct: 320 KGETQLTALVNRGVEYIEIRILDVNPFDKVGISVEQMNFLQVFNVFCLFEESKSIDEEQM 379 Query: 278 LLYKFNRFQACRYGLEGVITD--PHTGDRRPLTEDTLRLLEKIAPSAHKIG 326 N A G + + R PL + EK+ A + Sbjct: 380 ERINTNHQLAALLGRNEDLMLYKYNDDSRIPLKNFGDEIFEKLRIVAKLMD 430 >UniRef50_C2ZI28 Glutathione synthetase n=10 Tax=Bacilli RepID=C2ZI28_BACCE Length = 767 Score = 88.4 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 36/301 (11%), Positives = 96/301 (31%), Gaps = 55/301 (18%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 GIE E + V+ +L++ ++ + ++ D +E +E+ T V + + Sbjct: 30 RYGIEKESKRVDL-SGNLAKTDHP--KSISLRDDHPYIQRDFSELQMEIITPVTETLEEL 86 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC-------DNERYQR-TLENFG 124 +A+ V ++ + + P + +++ +N +Y++ ++G Sbjct: 87 FDYLAAIHDVAYRSMGK-NEMLWPLSMPPQLPEKDEDIVIAKLKNAENVQYRQTLSNSYG 145 Query: 125 YLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFIAL 164 ++ + G H + + + F Sbjct: 146 R--RKQMLCGVHFNFEFGDELIQALFNAQSEIKDYQHFKTEMYLKATRNYLHHRWLFTYF 203 Query: 165 SAASP-----YMQGTDTR---FASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTM 216 +SP + + D+ S R + + N S+ Q + + + + Sbjct: 204 YGSSPSSEKNFFE-EDSLKEVVRSIRSSKYGYTNSNDVQVSYSSIQNYVSDLSLMVKRGL 262 Query: 217 IDSIKDLHWDIRPSPHFGT----------VEVRVMDTPL--TLSHAVNMAGLIQATAHWL 264 + + ++ + +R +E+R +D T + A + +L Sbjct: 263 LSAEREFYSPVRLRGGHHASDLEDHGISYIELRNIDLNPFETYGFSYEQAEFLHLFLIYL 322 Query: 265 L 265 L Sbjct: 323 L 323 >UniRef50_C2C3Y2 Bifunctional glutamate--cysteine ligase/glutathione synthetase n=6 Tax=Firmicutes RepID=C2C3Y2_LISGR Length = 782 Score = 88.4 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 59/392 (15%), Positives = 115/392 (29%), Gaps = 79/392 (20%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V+ G L+ K +K D +ES +E+ T VC +N+ Sbjct: 27 FGLEKENLRVDRNGHLALTPHP----AIFGPKEDNCNIKTDFSESQVEMITPVCGSVNEV 82 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV---------CDNERYQR-TLEN 122 + +V + E+ ++P +++ ++ Y+ + Sbjct: 83 YDALHNLNNIVNN---EIGEELLWPSSNPAILPPEKDIPIAVYKTKDSEHRVYREHLAKE 139 Query: 123 FGYLIQQATVFGQHVHVGCAS-----------GDD----------AIYLLHGLSRFVPHF 161 +G + + G H + A +D + + + Sbjct: 140 YGK--KIQLLSGIHYNFSFAEDFLKQLYEKSAPEDTTYHTFKNQLYMQVASYFMKKRWLL 197 Query: 162 IALSAASPYMQGTDTRFASSRP--NIFSAFPDN-----------GPMPW---VSNWQQFE 205 + L+ ASP + T +++RP S P P ++ + Sbjct: 198 VYLTGASPVFENDFTAISNARPLNQNSSYLPTGMSLRNSAHGYKNSEPLNVKYDTFENYI 257 Query: 206 ALFRCLSYTTMIDSIKDLHWDIRPSPHF-------------GTVEVRVMDTPL----TLS 248 IDS+++ + IR +E+R +D +S Sbjct: 258 QSIANYIEAGTIDSMREYYNPIRLKNAHTDQTLESLAEKGVEYLEIRSIDLNPFELNGIS 317 Query: 249 HAVNMAGLIQAT-AHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPL 307 LI LLT + E + N R GL H + Sbjct: 318 KKTLH--LIHLMFLTALLTNQDDITWETAAASIEANEDLIARNGLSQPDLQLHPEGKIAF 375 Query: 308 TEDTLRLLEKIAPSAHKI--GASSAIEALHRQ 337 E + L+K+ + +E + Sbjct: 376 QEAAQQELDKMQQIIETLAPDQQHLLEVISEH 407 >UniRef50_Q65RX0 Glutathione synthetase n=83 Tax=Bacteria RepID=GSHAB_MANSM Length = 757 Score = 87.7 bits (216), Expect = 7e-16, Method: Composition-based stats. Identities = 64/406 (15%), Positives = 127/406 (31%), Gaps = 75/406 (18%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDV 65 F T+GIE E Q V+ G ++ + A N+ ++ D ES LEL T Sbjct: 16 FRQG---TVGIEKESQRVHADGSIVTSEHP---KAFGNRSYHPYIQTDFAESQLELITPP 69 Query: 66 CRDINQAAGQFSAMQKVVLQAATDHHLEI---CGGGTHPFQKWQ--RQEVCDNERYQR-T 119 + I SA+ +V L+ ++ G P Q+ + + + + Y+ Sbjct: 70 NKKIEDTLRWLSALHEVTLRTIDENEYIFPMSMPAGLPPEQEIRVAQLDNAADVAYREHL 129 Query: 120 LENFGYLIQQATVFGQHVHVGCASG----------------DDAIYLL-----HGLSR-F 157 + ++G + V G H + D L + L + Sbjct: 130 VASYGKA--KQMVSGIHYNFQLDPKLVETLFNAQTDYKSAVDFQNNLYLKMAKNFLRYQW 187 Query: 158 VPHFIALSAASP------YMQG---TDTRF-ASSRPNIFSAFPDNGPMPWVSNWQQFEAL 207 +P ++ LSA +P + G ++ S R + + + + +++ Sbjct: 188 IPLYL-LSA-TPTVEANYFKDGSPLKPNQYVRSLRSSKYGYVNAPDIIVSFDSIEKYVET 245 Query: 208 FRCLSYTTMIDSIKDLHWDIR----------PSPHFGTVEVRVMDTPLTLSHAVNM--AG 255 + + + K+ + ++R +E R+ D ++ +N+ A Sbjct: 246 LEHWVNSGRLIAEKEFYSNVRLRGAKKAREFLHTGIQYLEFRLFDLNPFEAYGINLKDAK 305 Query: 256 LIQ---ATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEG-VITDPHTGDRRPLTEDT 311 I WL E R G T R + Sbjct: 306 FIHHFILLMIWLEETADQDAVELGR----------ARLGEVAFEDPHSETAYRDEGEQII 355 Query: 312 LRLLEKIAPSAHKIGASSAIEALHRQVVS-GLNEAQLMRDFVADGG 356 +L++ + + A E Q + G + D + G Sbjct: 356 NQLIDMLKAIGAEQSAVEFAEEKLAQFANPGQTLCARLVDAIEQAG 401 >UniRef50_Q03Q55 Glutamate--cysteine ligase n=1 Tax=Lactobacillus brevis ATCC 367 RepID=Q03Q55_LACBA Length = 505 Score = 87.7 bits (216), Expect = 7e-16, Method: Composition-based stats. Identities = 56/423 (13%), Positives = 111/423 (26%), Gaps = 73/423 (17%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +G+E+E ++ G LSQ + ++ ++ D TES LE+ TD +I Sbjct: 23 VGLEIEEHRIDQHGR-LSQRPHP--RQLGSRTIHPYLQTDFTESQLEVITDPNPNIGGTL 79 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCD--------NERYQRTLENFGY 125 Q +Q V ++ I P + + + +G Sbjct: 80 DQLDTLQTVAYRSLAGDD-RIWPLSMPPKLDETDLQFVRNHFERPAIKPYREHLIHKYGL 138 Query: 126 LIQQATVFGQHVHVGCASG---------------------DDAIYLLHGLSRFVPHFIAL 164 + + G HV+ L R+ L Sbjct: 139 --KHGCMTGVHVNYSLPDPVINRLYSHYTQEFPTLVAFKNALYFRLAQNFVRYQWLLTYL 196 Query: 165 SAASP-----YMQGTDTRF----ASSRPNIFS--AFPDNGPMPWVSNWQQFEALFRCLSY 213 ASP + S R + F P + A + + Sbjct: 197 FGASPIAEAGFFDPVPAELQHPVRSIRNSRFGFVNLPQEQV--GYESLPGHLAQLQAMID 254 Query: 214 TTMIDSIKDLHWDIRPSPH----------FGTVEVRVMDTPLTLSHAVNMAGLIQA--TA 261 S + + +R +E+R D + V+ L Sbjct: 255 AGTYFSAHEFYGPVRLKGQNSAQNFLTGGIRYLELRDFDNTPFTPNGVSRHALYFLKFFM 314 Query: 262 HWLLTERPFKHQEKDYLLYK-FNRFQACRYGLEGVITDPHTGDRRPL-TEDTLRLLEKIA 319 +LLT+ ++ + N+ A L+ E +L Sbjct: 315 IYLLTQPLPENIATALATARLKNQTVALEDPLQATQYQAEGEQIFAAMREMAKQLNAHTE 374 Query: 320 -----PSAHKIGASSAIEALHRQVVS--GLN----EAQLMRDFVADGGSLIGLVKKHCEI 368 ++ + + V + + R + + S L+ + ++ Sbjct: 375 QWENIDDLEEVLMHPELTPAAKLVAKMHEGSLMKFGQAVARQWYHERISAPTLLPRLTQV 434 Query: 369 WAG 371 A Sbjct: 435 TAA 437 >UniRef50_C4DSG7 Gamma-glutamylcysteine synthetase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DSG7_9ACTO Length = 410 Score = 85.7 bits (211), Expect = 2e-15, Method: Composition-based stats. Identities = 53/345 (15%), Positives = 85/345 (24%), Gaps = 73/345 (21%) Query: 6 FHVSEPFTLGIELEMQVV---NPPG-----------YDLSQDSSMLIDAVKNKITAGEVK 51 F P G+ELE V +P + + + G V Sbjct: 34 FKTGPPALTGVELEHTVHRLDDPAEPVGLTELRTALGPFAPITIDPRSPSRRLPGGGSVT 93 Query: 52 HDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC 111 + +E+++ + + H L I G P + R Sbjct: 94 VE-PGGQVEISSLPHSGFPALHASVETDLRALEDLLRVHRLGIGDSGFDPRSRPGRLLRT 152 Query: 112 DNERYQRT---LENFGYLIQQAT---VFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALS 165 RY + G + G V V + L P +AL Sbjct: 153 P--RYDAMARAFDQHGTPHGSSMMVATAGLQVCVDSGRDTELPSRWAALHAMGPVLLALF 210 Query: 166 AASPYMQGTDTRFASSRPNIF-------------------SAF------------PDNGP 194 + S A R + SA+ +G Sbjct: 211 STS-----RRPDAACVRMRTWLGMEPGRTHAVATDTGDPVSAWVDYVLRAPVLCVRRDGR 265 Query: 195 MPWVSNWQQFEALF-RCLSYTTMID----SIKDLHWDIRPSPHFGTVEVRVMDTPLTLSH 249 + FEA L +D + L +RP G +EVR +DT Sbjct: 266 PWFTPRDVSFEAWLGGALPDPPSLDDLELHLSMLFPPVRPR---GYLEVRYLDTQPRRQW 322 Query: 250 AVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRF-QACRYGLE 293 +A + A ++ R+ A GL Sbjct: 323 FAPVAVIGALLASASSIDKVRDLCAP-----VEGRWLDAATRGLA 362 >UniRef50_B1MW57 Glutamate--cysteine ligase n=3 Tax=Leuconostoc RepID=B1MW57_LEUCK Length = 486 Score = 85.7 bits (211), Expect = 3e-15, Method: Composition-based stats. Identities = 46/327 (14%), Positives = 86/327 (26%), Gaps = 60/327 (18%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 GIE+E V LSQ ++ + T + D +ES E+ T V A Sbjct: 21 KFGIEIEEHRVQTDTLSLSQHPHP--ASLGKRKTHPYFQTDFSESQEEVVTAVQSSSAAA 78 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQ----EVCDNERYQRTLE----NFG 124 +Q ++ Q+ + I P+ + + YQ+ + +G Sbjct: 79 LQHLHELQFMLTQSLKG-NEFIWPLSMPPYLREADIIFLKTHFERPWYQKYRDVLFLRYG 137 Query: 125 YLIQQATVFGQHVHVGCASG-------------------DDAIYLLHGLSRFVPHFIALS 165 T G HV+ + ++ + L Sbjct: 138 PFQHIMT--GIHVNFSPEDSVIKNYANQHALTDYVTAKNKLFFQIAQQIAGYRWLLTYLF 195 Query: 166 AASPYMQGT----DTRF------ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCL---S 212 A+P + + + S R + F N+ F + L Sbjct: 196 GAAPVNENSSANLPNNYRKHQPVRSWRASNFG---FTNQPHIDVNYTDFNTHIKQLTNHI 252 Query: 213 YTTMIDSIKDLHWDIRPSPHF----------GTVEVRVMDTPL-TLSHAVNMA-GLIQAT 260 + + + +R +E R+ D T+ A + Sbjct: 253 TNGDLYDKSEFYGPVRLRASGSPNDLRINGADYLEFRMFDINPFTVDGISQDALSFLHLL 312 Query: 261 AHWLLTERPFKHQEKDYLLYKFNRFQA 287 + EK + N A Sbjct: 313 IIDAIINPENWEPEKLRIAKNKNHLVA 339 >UniRef50_A0AMA3 Glutathione synthetase n=15 Tax=Bacilli RepID=GSHAB_LISW6 Length = 776 Score = 83.8 bits (206), Expect = 8e-15, Method: Composition-based stats. Identities = 49/358 (13%), Positives = 95/358 (26%), Gaps = 68/358 (18%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V G L+ K +K D +ES +E+ T V I+ Sbjct: 27 FGLEKENIRVTSDGKLALTPHP----AIFGPKEDNPYIKTDFSESQIEMITPVTDSIDDV 82 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQ-RQEV-------CDNERYQRTLENFG 124 + +V + + P + + + +Y+ L G Sbjct: 83 YNWLENLHNIVS--LRSKNELLWPSSNPPILPAEKDIPIAEYKTPDSPDRKYREHLAQ-G 139 Query: 125 YLIQQATVFGQHVHVGCAS-----------------GDDAIYLLHGLSRFV----PHFIA 163 Y + + G H + D L ++++ I Sbjct: 140 YGKKIQLLSGIHYNFSFPEALIDGLYDEISLPNESKRDFKNRLYLKVAKYFMKNRWLLIY 199 Query: 164 LSAASPYMQGTDTRFA----------------SSRPNIFSAFPDNGPMPWVSNWQQFEAL 207 L+ ASP T+ S R + +++ + + Sbjct: 200 LTGASPVYLADFTKTKQEEKLRDGSSALHDGISLRNSNAGYKNKESLYVDYNSFDAYISS 259 Query: 208 FRCLSYTTMIDSIKDLHWDIRPSPHF-------------GTVEVRVMDTPLTLSHAVNMA 254 I+S+++ + IR +E+R +D + ++ Sbjct: 260 ISNYIEAGKIESMREFYNPIRLKNAHTDQTVESLAKHGVEYLEIRSIDLNPLEPNGISKE 319 Query: 255 GL--IQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTED 310 L I L + E + L N GL + L + Sbjct: 320 ALHFIHLFLIKGLLSEDRELCENNQQLADENENNIALNGLSKPAIKNCDNEEMALADA 377 >UniRef50_UPI0001C418FC bifunctional glutamate-cysteine ligase/glutathione synthetase GshF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C418FC Length = 474 Score = 83.8 bits (206), Expect = 9e-15, Method: Composition-based stats. Identities = 58/426 (13%), Positives = 121/426 (28%), Gaps = 88/426 (20%) Query: 11 PFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDIN 70 + GIE E V +LS + +K+T + D +ES +E+ T I+ Sbjct: 21 EGSFGIEWECLRV-KENGELSLSPHP--EIFGDKLTNPYITTDFSESQIEIITPAFDTID 77 Query: 71 QAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR-QEVCD-NER--------YQR-T 119 +A FS M +V + +D + + R Y++ Sbjct: 78 EAFSFFSFMSDLVNSSLSD-DEYLWFQSLPCILPESDKIPIAKYKGRGLGEESMEYRKGL 136 Query: 120 LENFGYLIQQATVFGQHVHVGCASG-----------------------DDAIYLLHGLSR 156 + +G ++ + G H + + + R Sbjct: 137 AKKYGL--KKQLISGIHFNFSFKEELIESFYDGVIGDKEKISYKEFKDSLYLKISRNYIR 194 Query: 157 FVPHFIALSAASPYMQGTDT-------------------RFASSRPNIFSAFPDNGPMPW 197 +V I L+ S + + T R S R + P Sbjct: 195 YVWLIIYLTGCSVAVHNSFTLDCQKLMNHKDNQGSVYSDRGPSFRNSSCGYKNLEHLYPS 254 Query: 198 VSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGT-------------VEVRVMDTP 244 ++ ++F + + K+L+ IR P + +E+R +D Sbjct: 255 YASVEEFTRDIQSFIDNGHLSEAKELYTQIRLKPRNPSDLLGSLNNNGIQYLEIRTLDIN 314 Query: 245 LTL-------SHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVIT 297 +I ++ +N + G E + Sbjct: 315 PFYKCGLIKNDMNFLHMFMIYLLIKEESDYESWQEDAL------YNEEKTAECGYEDGVK 368 Query: 298 DPHTGDRRPLTEDTLRLLEKIAPSAHKIG-ASSAIEAL--HRQVVSGLNEAQLMRDFVAD 354 G L + L +L+++ + + ++ L + + S L + + V Sbjct: 369 LIKDGKEVVLKDWALSILDEMEMMVESLNLENKSVIELMKLKIINSDLTYGRRLARLVEK 428 Query: 355 GGSLIG 360 G + Sbjct: 429 DGYIES 434 >UniRef50_C5R9H8 Glutamate--cysteine ligase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R9H8_WEIPA Length = 481 Score = 82.7 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 60/396 (15%), Positives = 122/396 (30%), Gaps = 67/396 (16%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 GIELE V G LS+ S + ++ ++ D +E+ EL T+ +A Sbjct: 24 KFGIELETHRVTRKGR-LSRASHS--TKLGSRRIHPYLQTDYSETQAELVTEAVGSFEEA 80 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN--ER-----YQR-TLENFG 124 + +Q V+ D + P K + D ER Y+ +G Sbjct: 81 RDRLLQLQWVLRSHMED-DEAVWPLSMPPELKKDDLQWLDETFERTWVQDYRDWLQHKYG 139 Query: 125 YLIQQATVFGQHVHVGCASG-------------------DDAIYLLHGLSRFVPHFIALS 165 + T G H++ + D ++ + F L Sbjct: 140 STHEIMT--GLHLNYSLSDEFLQHLFDASDRTNFKAFKNDVYFHIARQIVAHRWLFNYLF 197 Query: 166 AASPY-MQGTDTR-------FASSRPNIFSAFPDNGPMPWVS-NWQQFEALFRCLSYTTM 216 A+P+ + +D+R S R + + D G ++ + L Sbjct: 198 GATPFNLNDSDSRTPQFTKPVRSLRTSEYGFVNDKGEELTYDSDYANHQQQIEQLVSQGK 257 Query: 217 IDSIKDLHWDIRPSPHFG------TVEVRVMDTPLTLSHAVNMAG----LIQATAHWLLT 266 + S +++ +R +E+R++D ++ LI + L Sbjct: 258 LFSEHEIYGPVRFKRKIDDESEIEYLEIRILD--TDPFDIAGISENDLNLIHLLLIYFLV 315 Query: 267 ERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG 326 + + L I+ + +D L +++ I+ A G Sbjct: 316 KDDELTESALQHNED----------LSNRISLQQPTETLINKQDALAIMQDISQLADHFG 365 Query: 327 AS--SAIEALHRQVVS-GLNEAQLMRDFVADGGSLI 359 + + +V++ A M +D + Sbjct: 366 MRFNDGLSLITDRVLTPSKTPAAKMIAVASDTTEMQ 401 >UniRef50_Q15W46 Glutamate--cysteine ligase n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15W46_PSEA6 Length = 533 Score = 80.7 bits (198), Expect = 7e-14, Method: Composition-based stats. Identities = 62/427 (14%), Positives = 114/427 (26%), Gaps = 107/427 (25%) Query: 15 GIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE E + P G + + L A+ T + D +ES+LE T +++++ Sbjct: 34 GIEREALRIQPNGKLAQTPHNEKLGAAL----THDYITTDFSESLLEFITPPEQNVDKTL 89 Query: 74 GQFSAMQKVVLQAATDHHLE-ICGGGTHPFQKWQ-RQEVCD---------NERYQR-TLE 121 GQ + K A + E + + Q + Y+ Sbjct: 90 GQLRDVHKF---ALANIGDECLWPMSMPCYIDDQNEIPIAQFGKSNVGKMKSLYREGLKN 146 Query: 122 NFGYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHF 161 +G + + G H + L+ RF Sbjct: 147 RYGSM--MQAIAGVHFNFSLPDSFWDLWLDKVESSENNKETKSAAYFALIRNYRRFCWLI 204 Query: 162 IALSAASP-----YMQGTDTRFA---------------SSRPNIFSAFPDN--GPMPWVS 199 L ASP +++G +T S R + G M + Sbjct: 205 PYLYGASPALCSSFIKGKNTTLPFKTIGKGSLYLPYATSLRMSDLGYTNSAQSGLMTCYN 264 Query: 200 NWQQFEALFRCLSYTT---------------------MIDSIKDLHWDIRPSP-----HF 233 + A R T M+ +L+ IRP Sbjct: 265 QVDSYIASLRKAISTPSEIFEKYAGKKDGQYQQLNSNMLQIENELYSPIRPKQPTKPLEK 324 Query: 234 GT----------VEVRVMDTPL--TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 T +EVR +D + N + + + Y + Sbjct: 325 PTDALQARGVEYIEVRALDVDPFSDIGIERNQFFFLDVFLVYCVVMPSPDMTPDSYRETE 384 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 N +G + + G P+T+ L + A + ++ A+ + V Sbjct: 385 TNLRAVVDHGRDPELMLSKEGKSVPMTQWAAELFAGMREVAKVLDSNHAVAEYSQAVEQ- 443 Query: 342 LNEAQLM 348 + Sbjct: 444 ----EWQ 446 >UniRef50_Q8DW15 Glutathione synthetase n=7 Tax=Streptococcus RepID=GSHAB_STRMU Length = 754 Score = 80.0 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 37/276 (13%), Positives = 80/276 (28%), Gaps = 52/276 (18%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E +N + L+Q A+ ++ ++ D +ES +EL T V + Sbjct: 21 FGLERESLRINKTNHRLAQTPHP--TALGSRQFHPYIQTDYSESQMELITPVAHSSKEVL 78 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNE-----RYQ-RTLENFGYLI 127 A V + + D + + P E+ E Y+ + +G + Sbjct: 79 RFLGA-ITDVAERSIDQNQYLWPLSMPPQITEDEIEIAQLEDDFEFSYRQYLDKKYGKI- 136 Query: 128 QQATVFGQHVHVGCASG-------------------DDAIYLLHGLSRFVPHFIALSAAS 168 ++ G H ++ + D + + + L AS Sbjct: 137 -LQSISGIHYNMELGADLMNELFELSGYQSFIDFKNDLYLKVAQNFLNYRWFLTYLYGAS 195 Query: 169 PYMQGTDTRF---------ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDS 219 P + F S R + + + + + + + + + Sbjct: 196 PLAEK---GFLNEELSQTVRSIRNSHLGYVNTDDIKVPFDSLENYISSIEHYVKSGALSA 252 Query: 220 IKDLHWDIRPSPHFG----------TVEVRVMDTPL 245 K+ + +R +E R D Sbjct: 253 EKEFYSAVRLRGSKHNRDYLTKGITYLEFRCFDLNP 288 >UniRef50_Q38XD9 Putative glutamate-cysteine ligase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38XD9_LACSS Length = 759 Score = 79.6 bits (195), Expect = 2e-13, Method: Composition-based stats. Identities = 41/277 (14%), Positives = 78/277 (28%), Gaps = 51/277 (18%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 GIE E V LS S ++ ++ +K D E EL +D + ++ Sbjct: 23 FGIEKEGHRVTAA-GQLSPLSHP--ASLGSRDFHPYIKTDFAEMQTELVSDTFDNTDEIM 79 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV-----CDNER-YQ-RTLENFGYL 126 Q A+ +V+ D I P + + R Y+ +G Sbjct: 80 QQLGALSEVLEMNLAD-DELIWPLSMPPVLPSDETTIPIADVAPDARAYRDYLANRYGR- 137 Query: 127 IQQATVFGQHVHVGCASGDDA----------------------IYLLHGLSRFVPHFIAL 164 + + G H + A A + + S++ L Sbjct: 138 -RLQMISGVHFNFSLAPALIARLYDEVYHDQFATVKDFSDMLYLQIAQNYSQYRYLLTYL 196 Query: 165 SAASPYMQGT---------DTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTT 215 ASP + D S R + + ++ + + + Sbjct: 197 FGASPITEALFQTDTTNLPDYAVRSLRSSQLFGYANHDLVVSFESVAAYHDSLEQAISKK 256 Query: 216 MIDSIKDLHWDIRPSPHFG-------TVEVRVMDTPL 245 + S ++ + +R H +E R D Sbjct: 257 QLISEREYYGSVRLRSHGHLAQDGVDYLEFRGFDLNP 293 >UniRef50_Q48PX1 Glutamate--cysteine ligase n=86 Tax=Proteobacteria RepID=GSH1_PSE14 Length = 535 Score = 77.6 bits (190), Expect = 6e-13, Method: Composition-based stats. Identities = 64/416 (15%), Positives = 115/416 (27%), Gaps = 98/416 (23%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAG 74 GIE E V +L+Q A+ +T G+V D +ES+LE T ++ + Sbjct: 32 GIERECLRV-TATAELAQTPHP--QALGAALTNGQVTTDYSESLLEFITPALKNPAETID 88 Query: 75 QFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY--------QRTLEN---F 123 + + E+ + P +E Y + Sbjct: 89 SLDKIHRFAYS---KLGDELLWSPSMPC-PLPDEEHTPIAYYGTSNIGKLKYVYRKGLAL 144 Query: 124 GYLIQQATVFGQHVHVGCAS---------GDDA-----------IYLLHGLSRFVPHFIA 163 Y + G H + D A I L+ R+ + Sbjct: 145 RYGKTMQCIAGIHYNFSLPEDAWALLKQTEDFAGDARDYQSHSYIALIRNFRRYSWLLMY 204 Query: 164 LSAASP-----YMQGT----------DTRFA----SSRP--NIFSAFPDNGPMPWVSNWQ 202 L ASP +++G DT + S R + + P ++ Sbjct: 205 LFGASPALDAGFLRGRKHQLEQHFDADTLYLPYATSLRMSDLGYQSDAQADLTPCYNDLV 264 Query: 203 QFEALFRCLSYTT----------------------MIDSIKDLHWDIRPSPH-------- 232 + R T ++ + + +IRP Sbjct: 265 SYTDSLRKAVATPYKPYVDVGTHDQNGEWVQLNTNVLQIENEYYSNIRPKRATYSGERPI 324 Query: 233 -------FGTVEVRVMDTPLTLSHAVNM--AGLIQATAHWLLTERPFKHQEKDYLLYKFN 283 VEVR +D L +++ + I A + E + + N Sbjct: 325 QALVARGVQYVEVRCLDINPFLPTGISLEQSRFIDAFVLYCALEESQQLASHECSNASSN 384 Query: 284 RFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVV 339 + G ++ L LLEKI P A + + I+ + + Sbjct: 385 FLAVVKEGRRPGLSLQRNNSPVDLKTWATELLEKITPIARLLDQAQGIDEHIKSIA 440 >UniRef50_Q21SH8 Glutamate--cysteine ligase n=1 Tax=Rhodoferax ferrireducens T118 RepID=Q21SH8_RHOFD Length = 518 Score = 77.6 bits (190), Expect = 7e-13, Method: Composition-based stats. Identities = 58/438 (13%), Positives = 116/438 (26%), Gaps = 99/438 (22%) Query: 13 TLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 T G E E V+ L+Q L + +K+T + D +E++LE T +D Sbjct: 26 TRGYERECLRVDR-SGTLAQTPHPL--TLGSKLTHPWITTDYSEALLEFITPPSQDPAFP 82 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPF------QKWQRQEVCDNERYQRTLEN---F 123 + + Q + G + R++ Sbjct: 83 LQFLRDIHRYSAQQLQ--GEYLWAGSMPCVLSTDQAIPIADYGPSNAARFKYVYREGLGL 140 Query: 124 GYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFIA 163 Y Q T+ G H + + + L+ RF Sbjct: 141 RYGRQMQTIAGAHYNWSLPADFWLALQDCCCAKNVGQAFVSERYFGLIRNFLRFGWLIPY 200 Query: 164 LSAASP-----YMQGTDTRFA-------------SSRP--NIFSAFPDNGPMPWVSNWQQ 203 L ASP +++G + S R + V++ + Sbjct: 201 LFGASPAICESFLRGHPSDLPELVPGTRYGPYATSLRMSDLGYQNRAQANLHISVNSLAE 260 Query: 204 FEALFRCLSYTT---------------------MIDSIKDLHWDIRPSPHFG-------- 234 + T ++ + + + IRP Sbjct: 261 YTQALEAAIRTPDPYYEQLGVRDGDHWKQLNANLLQTESEYYAGIRPKRVGHDRPAKALQ 320 Query: 235 -----TVEVRVMDTPLTLSHAVNM--AGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQA 287 +E+R+ D + + + L ++ N+ + Sbjct: 321 RDGVEYIEMRLFDLNPFIDIGIAPEQSTFADVLLLMCLFRDSPPITSREQSENDENKHRI 380 Query: 288 CRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGA-------SSAIEALHRQVVS 340 YG + + +P L + + P A + A SS ++ L ++ Sbjct: 381 VNYGRQPGLQLLVHNREQPFRSLAHELFDDMQPFADMLDAAYGGQRYSSTMQGLRTRIDQ 440 Query: 341 GLN--EAQLMRDFVADGG 356 + AQ++ GG Sbjct: 441 PDSTPSAQVLEAARTQGG 458 >UniRef50_Q21EP1 Glutamate--cysteine ligase n=2 Tax=Gammaproteobacteria RepID=GSH1_SACD2 Length = 530 Score = 77.3 bits (189), Expect = 1e-12, Method: Composition-based stats. Identities = 57/419 (13%), Positives = 118/419 (28%), Gaps = 101/419 (24%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAG 74 GIE E ++ L+Q + A+ + +T ++ D +E++LE T + Sbjct: 26 GIEREGLRIDRD-GKLAQTPHPV--ALGSALTHPQITTDFSEALLEFITPPTHRVEDLFK 82 Query: 75 QFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLENF 123 Q +Q + E+ + P +Y R Sbjct: 83 QLYDIQGY---TLSKLDDELIWSSSMPCV-LNDDATIPVAQYGSSNNGTMKTVYRVGLGH 138 Query: 124 GYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHFIA 163 Y TV G H + L+ R+ + Sbjct: 139 RYGRAMQTVAGLHYNFSLPDAFWSFLHREEYSLLDLQDFKDQKYFALIRNFRRYYWLLVY 198 Query: 164 LSAASPYMQGT-----------------------------DTRFA-SSRPNIF------S 187 L ASP + G+ D + S++ +++ Sbjct: 199 LFGASPALCGSFIKGREHNLQPLIDERTLHLPYATSLRMGDLGYQSSAQESLYVCYNDKQ 258 Query: 188 AFPDNGPMPWVSNWQQF-------EALFRCLSYTTMIDSIKDLHWDIRPSPHFGT----- 235 ++ + ++ E T+++ + + IRP Sbjct: 259 SYITTLCAAITTPIDEYKAIGLQDEKGEFKQLNTSLLQIENEFYSSIRPKRTAKHGETAL 318 Query: 236 ----------VEVRVMDTPLTLSHAVN---MAGLIQATAHWLLTERPFKHQEKDYLLYKF 282 +EVR +D VN + L + L + P E+ + + Sbjct: 319 SALRNRGVEYIEVRCLDIDPFDPLGVNKPQVRFLDTFLLYCALQDSPDTSPEESANILR- 377 Query: 283 NRFQACRYGLE-GVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVS 340 N+ G + + T + PL + L++ + P A + + E + + + Sbjct: 378 NQKTVVTEGRSPKALIESFTKGKIPLKQAGEALIKAMRPVAELLDIAHETEEHTQSLET 436 >UniRef50_Q0AVA1 Gamma-glutamylcysteine synthetase-like protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AVA1_SYNWW Length = 479 Score = 76.9 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 71/444 (15%), Positives = 127/444 (28%), Gaps = 87/444 (19%) Query: 6 FHVSEPFTLGIELEMQVVNPPGYDLSQD-SSMLIDAVKNK-------------------I 45 F +G+E+EM VVN + + ++D +K + + Sbjct: 24 FAGKGEPCIGVEIEMPVVNLACRAVEPGFIAAMLDLLKQRFAFTPTRFDQNGFPIEAVNL 83 Query: 46 TAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKW 105 + T + +E A I+Q A F + + + A +HH ICG G +P+ + Sbjct: 84 QQDAFSFETTFNTIEFAMAKKPGIDQIAANFYSYVTALQELAHEHHHLICGMGINPYAAY 143 Query: 106 QRQEVCDNERYQRTLENFGYL-----IQQATVF-----GQHVHVGCASGDDAIYLLHGLS 155 + ++ L +L +F H+ LL+ L Sbjct: 144 ADSKPLNSP---VMLAKTEFLKNFTSHHDGEIFHAFSAACQTHLDV-ELTQLPDLLNLLG 199 Query: 156 RFVPHFIALSAAS-PY-MQGTDTRFA---------------SSRPNIFSAFPDNGPMPWV 198 + L A S P+ G A R ++ P+ Sbjct: 200 KLAFVDAMLFANSLPFIYAGNRNFTARLPASLQREMAHPTLCFRDILWRLCEAPNVRPYD 259 Query: 199 SNWQQFEALFRCLSY----------TT--MIDSIKDLHWDIR-----------------P 229 ++ E + + L + I ++ + R Sbjct: 260 RDYASLEEVVKHLLDLKIFITSDGSSGFKAIPPVRFADYIARDRWSEADLSCFRSLEPVA 319 Query: 230 SPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACR 289 GTVE+R T L+ + A A + H + Q R Sbjct: 320 VSRHGTVEIRQTCTQP-LADSFAPAAFYTGIAENITVASELVHDFWQDNQINISNSQLRR 378 Query: 290 YGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSA--HKIGASSAIEALHRQVVSGLNEAQL 347 + +T P L E LL A K G + + N AQ Sbjct: 379 QAVSREMTIPADR----LQEFINNLLAIAAAGLKKRKRGEDKYLGRFLKPDHELKNPAQR 434 Query: 348 MRDFVADGGSLIGLVKKHCEIWAG 371 D + +G S+ ++ + Sbjct: 435 QLDLLQEGWSIQEIMSACSALDES 458 >UniRef50_C0WQG0 Glutamate--cysteine ligase n=3 Tax=Lactobacillus RepID=C0WQG0_LACBU Length = 508 Score = 76.5 bits (187), Expect = 2e-12, Method: Composition-based stats. Identities = 57/376 (15%), Positives = 97/376 (25%), Gaps = 66/376 (17%) Query: 14 LGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 +GIE+E + LSQ + + ++ ++ D +ESM EL TD +I Sbjct: 23 IGIEIEEHRI-EGDGQLSQHPYP--ENLGSRKYHPYLQSDFSESMNELITDPNPNIGGVL 79 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDN----ERYQRTLENF--GYLI 127 Q +Q V+ + D I P +N +Q + Y + Sbjct: 80 DQLDTIQTVLYHSMKD-DEYIWPLSMPPALSDDDIHFVENHFARPPFQEYRDYLTKKYKV 138 Query: 128 QQATVFGQHVHVGCASG---------------------DDAIYLLHGLSRFVPHFIALSA 166 V G HV+ + L Sbjct: 139 PLKIVTGLHVNFSIPEPVVNRLYTHYEGQFKSLVEFKNALYFQIAQNFVLHRWLLTYLFG 198 Query: 167 ASPYMQ-GTDTR---------FASSRPNIFSAFPDNGPMP------WVSNWQQFEALFRC 210 ASP + G + S R +I+ S+ + Sbjct: 199 ASPIAEKGFFSGETPAPLTHPVRSIRNSIYGYVNK---PEDQVNVTLYSSLGNYIDRISN 255 Query: 211 LSYTTMIDSIKDLHWDIRPSPHF----------GTVEVRVMDTPL-TLSHAVNMAGLIQA 259 + S + + +R +E RVMD T + A Sbjct: 256 AIDQHRLFSPAEFYGPVRLRGQGALKDYRTKGISYLEFRVMDNTPFTPNGISRHALYFLK 315 Query: 260 TAHWLLTERPFKHQEKDYLL---YKFNRFQACRYGLEGVITDPHTGDR-RPLTEDTLRLL 315 L +P L + N A + + R L E +L Sbjct: 316 FFLMYLLVQPVDETRIHDKLKQSFDDNNRVALESPDQPTFKEAEGLKIFRNLIEMAKQLH 375 Query: 316 EKIAPSAHKIGASSAI 331 + + S + Sbjct: 376 AH-SEQLQALDDFSEV 390 >UniRef50_B8GMF6 Glutamate--cysteine ligase n=1 Tax=Thioalkalivibrio sp. HL-EbGR7 RepID=B8GMF6_THISH Length = 524 Score = 76.1 bits (186), Expect = 2e-12, Method: Composition-based stats. Identities = 65/451 (14%), Positives = 108/451 (23%), Gaps = 108/451 (23%) Query: 14 LGIELEMQVVNPPGY-DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G+E E VNP G + L A+ + D +E++LE T D QA Sbjct: 26 MGLEKESLRVNPEGGIARTPHPPALGSALA----HPWITTDYSEALLEFITPPFADPRQA 81 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLE 121 +Q E + P + RY R Sbjct: 82 LEFLCDLQTFTYP---RMGEEFLWATSMPCVVAGEDAI-PVARYGDSNAGRMKTVYRLGL 137 Query: 122 NFGYLIQQATVFGQHVHVGCAS--------------------GDDAIYLLHGLSRFVPHF 161 Y + G H + ++ L R Sbjct: 138 GHRYGRVMQVIAGVHFNFSVPEAFWPVFQKLEGHSGSLREFTDASYFAMIRNLQRLGWLV 197 Query: 162 IALSAASP-----YMQGTDT------------RFA-SSRPNIFSAFPD----NGPMPWVS 199 L ASP ++ G T +A S R G Sbjct: 198 PYLFGASPAVCKSFLAGKPTHMPEFNENTYYEPYATSLRMGDIGYQNRKEEETGIKASYD 257 Query: 200 NWQQFEALFRCLSYT--------TMIDS-------------IKDLHWDIRPSP------- 231 + + + C T ++ + + +RP P Sbjct: 258 SLEAYTDSLACAIGTPSPEYEKLGVVVDGEYRQLNANILQIENEYYSSVRPKPIVEGNEK 317 Query: 232 --------HFGTVEVRVMDTPL--TLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYK 281 VE+R +D L ++A L E + L Sbjct: 318 PVVALRKRGVRYVELRSLDVNAFEPLGVCETQLRFLEAFMFTCLLMDSPVIGEVERLQID 377 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSG 341 N+ A G + + GD L + +L +AP + Sbjct: 378 RNQSAAAHRGRDPSLRLLRNGDEILLRDWADEVLVAMAPLCAALDGDDPARPYSS----- 432 Query: 342 LNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 + A+ SL + E+ + Sbjct: 433 -SLARQQEKVA--DPSLTPSARMLAEMSERE 460 >UniRef50_B8I2B6 Glutamate--cysteine ligase n=2 Tax=Clostridium RepID=B8I2B6_CLOCE Length = 474 Score = 75.7 bits (185), Expect = 2e-12, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 68/235 (28%), Gaps = 45/235 (19%) Query: 15 GIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E Q VN G L+ A NK+ +V D ES +EL T +++ Sbjct: 26 GVEREAQRVNTNGCLALTDHP----AAFGNKLLNNKVTTDFAESQIELITPPMSSVDEVY 81 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQK-WQRQEV-----CDNER----YQR-TLEN 122 + V+ + P +R + R Y+ Sbjct: 82 KFLKLLTLEVIHELKSE--LLWPFSMPPILPSEERIPIAKYDDTPEGREKEIYRLGLANR 139 Query: 123 FGYLIQQATVFGQHVHVGCA---------------SGDDAIYL-----LHGLSRFVPHFI 162 +G + + G H ++ + + ++ I R+ I Sbjct: 140 YGK--KMQMISGIHFNLSFSEGLFDTLYKYFGNGENRNEFIDKSYFAMARNFLRYRWLLI 197 Query: 163 ALSAASPY----MQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSY 213 L ASP S R + F + ++ ++ + L Sbjct: 198 YLFGASPIADITFNSEIPNATSLRVSQFGY-SNAEQGNFIVSYNDKSEYLQNLRK 251 >UniRef50_A5EXD0 Glutamate--cysteine ligase n=2 Tax=Cardiobacteriaceae RepID=A5EXD0_DICNV Length = 512 Score = 75.3 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 53/412 (12%), Positives = 106/412 (25%), Gaps = 93/412 (22%) Query: 1 MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLE 60 M L F ++ +G+E E S ++ V T + D +E++LE Sbjct: 1 MTLNTFPLAGGL-IGVERETLRTTADARLASTRHPEILGNV---YTHPNITIDYSEALLE 56 Query: 61 LATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVC--------- 111 TD + + Q + + Q ++ + + Sbjct: 57 FVTDAHPSVQKTYQQLLHLHQYTAQHLQQE--QLWSVSMPCRLPENPEHIEIGYFGSSNG 114 Query: 112 -DNERYQRTLENFGYLIQQATVFGQHVHVGCASG-------------------DDAIYLL 151 R R + Y + G H + + + + +L Sbjct: 115 GKKSRLYRVGLAYRYGRAMQMIAGVHFNYSPPAALWQALADACGVALSVDWQNERYMGML 174 Query: 152 HGLSRFVPHFIALSAASPY-------MQGTDTRFASSRPNIFS--------AFPDNGPMP 196 + R L AS Q TR R + + Sbjct: 175 RNIQRHGWLICHLFGASSATDISFQPAQNILTRRHD-RTLNWQNATSLRMSQLGYQNKVD 233 Query: 197 WVSNWQQFEALFRCLSYTTMIDSI-------------------------KDLHWDIRPS- 230 + ++ + R LS + + + + RP Sbjct: 234 FHISFNNLKDYVRDLSAAVLTPAPVYEYLGLKDPAGHYRQMNTNILQIENEYYSSARPKQ 293 Query: 231 --------------PHFGTVEVRVMDTPLTLSHAVNMA--GLIQATAHWLLTERPFKHQE 274 +E+R++D + V++A ++ W L Sbjct: 294 SIKEHEQPAVALNQRGIAYIELRLLDINPYDAAGVSVAQMRFLECFLLWCLLHDAPYFTT 353 Query: 275 KDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIG 326 DY NR + GL T + + +L+++ P A + Sbjct: 354 ADYNEANHNRLRTACCGLSPAFTLFNNKRQITARGWAAEILDQLLPIAENLD 405 >UniRef50_Q2NGX6 GshA n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NGX6_METST Length = 467 Score = 75.3 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 53/411 (12%), Positives = 113/411 (27%), Gaps = 77/411 (18%) Query: 14 LGIELEMQVVNPPG-YDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 G+E E V G L+ + +K+ + D +ES +E+ T +N+ Sbjct: 24 FGLEKEGLRVTKDGNLSLTPHPEV----FGDKLKNPYITTDFSESQIEIVTPSFNTLNEV 79 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV-------CDNERYQR---TLEN 122 S ++ + I P ++ + Y+ + Sbjct: 80 YQFLS-FISDLVNINIPDNEYIWNQS-LPCIIPDDSKIPIAKYSKEGKDAYEYRKNLSKK 137 Query: 123 FGYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFI 162 +G + + G H + + ++ R+ I Sbjct: 138 YGR--KLQLISGIHYNFSFDEKVIEKLYKNISHDLSYKNFKNQLYLKIVRNYLRYKWLII 195 Query: 163 ALSAAS------------PYMQGTD-------TRFASSRPNIFSAFPDNGPMPWVSNWQQ 203 L+ S M D T S R P ++ + Sbjct: 196 YLTGTSIACHETFIEKCYNLMNKKDNYDSYYGTEAVSYRNASCGYKNKTPLYPRYTSVDE 255 Query: 204 FEALFRCLSYTTMIDSIKDLHWDIRPSPHFG-------------TVEVRVMDTPLTLSHA 250 F + ++ K+L+ IR PH +E+R +D Sbjct: 256 FIRDVKDFINKGLLSESKELYTQIRLKPHDRNNFLKSLKEDGIQYIEIRTIDINPFDKCG 315 Query: 251 VNM--AGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLT 308 ++M I +LL + + + N + + G L Sbjct: 316 ISMEDMEFIHIFLLYLLLKEESTYDKWQEESL-INEENTAENAFNTNLKLLNDGCEVSLK 374 Query: 309 EDTLRLLEKIAP--SAHKIGASSAIEALHRQVVS-GLNEAQLMRDFVADGG 356 ++ +I + +G I + ++ + A +R+ + + G Sbjct: 375 NWAFNIINEIKQINTRLDLGKDEIIHTMQERIENPKKTHAYKLRNIIKNKG 425 >UniRef50_C2CYS8 Glutamate--cysteine ligase n=3 Tax=Lactobacillus RepID=C2CYS8_LACBR Length = 500 Score = 75.3 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 41/291 (14%), Positives = 83/291 (28%), Gaps = 62/291 (21%) Query: 7 HVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVC 66 + F +GIE+E ++ G ++ A+ N+ +K D+ + E+ T Sbjct: 59 AKASDFNMGIEVETIRIDSSGRLTKEEYP---KALGNQRKNHFIKTDVYQIQSEVITPAA 115 Query: 67 RDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQR-----QEVCDNER-YQRTL 120 R A A+ + A + + P + V ++R Y Sbjct: 116 RKSLDAMHYLMALNDTLRNALEP-NELLWPLSMPPILPRDKKTIPIANVDPDQRAYYE-- 172 Query: 121 ENFGYLIQQATVFGQ----HVHVGC----------ASGDDA-----------IYLLHGLS 155 ++ ++ G H++V A D I + G Sbjct: 173 ---RWINTRSDTQGIPVGVHLNVSVNETVLKTVWEAEKDKFDSYPEFVNYMYIKIAQGFV 229 Query: 156 RFVPHFIALSAASP-----YMQGTDT----RFASSRPNIFSAFPDNGPMPWVSNWQQFEA 206 + L SP + + D S R + + + + + Sbjct: 230 YYRWLITYLFGNSPIAEKNFFKAEDDQPAHAVRSIRSSNYG--LTSDIKKDYRSVADYVH 287 Query: 207 LFRCLSYTTMIDSIKDLHWDIRPSPHFG-----------TVEVRVMDTPLT 246 + S + H +R G +E+R++D T Sbjct: 288 NIESHIEDGTLFSEAEYHASVRLKTVHGDLTKMVKNGVDYIELRMLDLDPT 338 >UniRef50_C0XJ04 Glutamate--cysteine ligase n=3 Tax=Lactobacillus RepID=C0XJ04_LACHI Length = 445 Score = 75.0 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 43/307 (14%), Positives = 100/307 (32%), Gaps = 47/307 (15%) Query: 14 LGIELEMQVVNPPGY-DLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQA 72 +G+E+E +N G S L+ ++ +K+D E+ EL T + ++ Sbjct: 18 VGLEVETHRINTDGGLSTHPYPSGLL----DEKKHHFIKNDFLETQSELITPPEENTHRG 73 Query: 73 AGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV----CDNER--YQRTLENFGYL 126 A + + T + P + ++ D++ Y++ + + Sbjct: 74 LTYLGAYHQALRSELTSSEY-LWPYSMPPKLRLDHADIEIAQTDHDNYVYRQKVAQIRRI 132 Query: 127 IQQATVFGQHVHVG----------CASGDDAI-----YLLHGLSRFVPHFIALSAASPY- 170 + A G HV++G D I G + L A+P+ Sbjct: 133 ERTAET-GVHVNIGLTPAAIHQIEVPPTQDEIDSLYLQAAIGFMNYRWLLTYLFGATPFA 191 Query: 171 MQGTDTRFASSRPNIFSAFPDN------GPMPWVSNWQQFEALFRCLSYTTMIDSIKDLH 224 ++ A+ + ++ G + + ++ I + ++ + Sbjct: 192 FDNYFSKTANMPAQAVRSLRNSHFGFGNGFLASYRSVSEYVTDIEDAVRDHEIIAEREYY 251 Query: 225 WDIRPS--PHFG--------TVEVRVMDTPLTLSHAVN--MAGLIQATAHWLLTERPFKH 272 +R PH +E+R+ D ++ +I+ + +PF Sbjct: 252 GTVRLKRTPHLKDLLADGILYIELRIYDLDPFEPMGISEDAVNIIRLMFAYFAGNQPFNL 311 Query: 273 QEKDYLL 279 E D+ + Sbjct: 312 DESDHEI 318 >UniRef50_C1DJH1 Glutamate--cysteine ligase n=4 Tax=Gammaproteobacteria RepID=GSH1_AZOVD Length = 530 Score = 74.2 bits (181), Expect = 7e-12, Method: Composition-based stats. Identities = 62/444 (13%), Positives = 113/444 (25%), Gaps = 109/444 (24%) Query: 15 GIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAG 74 GIE E V+ +L++ A+ + +T + D +E++LE T D Sbjct: 27 GIERECLRVDAA-GELARTPHP--AALGSALTHPYITTDYSEALLEFITPAETDSAATLA 83 Query: 75 QFSAMQKVVLQAATDHHLEICGGGTH-PFQKWQRQEVCDNERY-----------QRTLEN 122 + + + P + + RY R Sbjct: 84 ALERVHRFACAKLD--GEYLWSPSMPCPLPAEEDIPI---ARYGNSHIGRLKHVYRKGLA 138 Query: 123 FGYLIQQATVFGQHVHVGCASG-----------------------DDAIYLLHGLSRFVP 159 Y + G H + + I L+ R+ Sbjct: 139 LRYGKTMQCIAGIHYNFSLPEELWPLLQRAEGDVRGVRGVRDFQSERYIALIRNFRRYSW 198 Query: 160 HFIALSAASP-----YMQGTD-------------TRFASSRP--NIFSAFPDNGPMPWVS 199 + L ASP +++G S R + P + Sbjct: 199 LLMYLFGASPALDKSFLRGRPHHLQELDAETLYLPWATSLRMSDLGYHNNAQADLTPCYN 258 Query: 200 NWQQFEALFRCLSYTT---------------------MIDSIKDLHWDIRPS-------- 230 + + R T ++ + + IRP Sbjct: 259 DLASYTDSLRRAVSTPYAPYAAIGTQRDGEWLQLNTNVLQIENEYYSTIRPKRVTASGER 318 Query: 231 -------PHFGTVEVRVMDTPLTLSHAVNM--AGLIQATAHWLLTERPFKHQEKDYLLYK 281 VEVR +D L +++ A + A + E + Sbjct: 319 PIQALVARGVQYVEVRCLDIDPFLPLGIDLDEARFLDAFLLFCALEDSPCLAAGECASCT 378 Query: 282 FNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKI-------GASSAIEAL 334 N + + G + G PL LLE++ P A G A+ A Sbjct: 379 GNFLKVVKEGRRPGLHLQRHGQPMPLAAWAGELLERLQPLAALFDRAYGGDGYEKALHAQ 438 Query: 335 HRQVVS-GLNEAQLMRDFVADGGS 357 +V L + + + + G Sbjct: 439 QAKVADPELTPSARLLATLRERGE 462 >UniRef50_D1VQH9 Glutamate/cysteine ligase family protein n=1 Tax=Frankia sp. EuI1c RepID=D1VQH9_9ACTO Length = 553 Score = 74.2 bits (181), Expect = 8e-12, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 60/216 (27%), Gaps = 42/216 (19%) Query: 11 PFTLGIELEMQVVNP-----------------------------PGYDLSQDSSMLIDAV 41 P ++G+E E VV+ + + AV Sbjct: 80 PRSVGVETEWLVVDRAANDAPVPPERTSAALAPLLATLGSNGSAASGEPAGAVPDATGAV 139 Query: 42 KNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHP 101 + + LEL+ ++ A A V A D L + G G P Sbjct: 140 --LAGGSRLTFE-PGGQLELSGAPLP-LSAALDAVRADLAQVRAALADAGLALAGLGLDP 195 Query: 102 FQKWQRQEVCDNERYQRTLENFGYLIQQ----ATVFGQHVHVGCA---SGDDAIYLLHGL 154 + R D RY + V + D + Sbjct: 196 LRPPTRWLTDD--RYASMAGYWAASGHDAGRIMMCSSASVQINLDAGADPLDIVRRWRLA 253 Query: 155 SRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFP 190 R P +A+ AASP G T F S+R ++ + Sbjct: 254 HRLRPVLVAMFAASPARLGRLTGFGSARTRMWESLD 289 >UniRef50_C6VI68 Glutamate--cysteine ligase n=4 Tax=Lactobacillus plantarum RepID=C6VI68_LACPJ Length = 412 Score = 73.4 bits (179), Expect = 1e-11, Method: Composition-based stats. Identities = 54/387 (13%), Positives = 112/387 (28%), Gaps = 65/387 (16%) Query: 14 LGIELEMQVVNPPGYDLSQDS--SMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQ 71 +G+E E Q V L+ + LI + ++ D E+ LEL T Sbjct: 21 IGLEREGQRV-TVTGHLADTALSPTLISELSG------LQRDFAETQLELVTQPQASAVA 73 Query: 72 AAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEV------CDNERYQR-TLENFG 124 A + + + V Q I P + +++ Y++ +G Sbjct: 74 ALHALTMLTQQVRQRLLPE--LIWPLSMPPTLPREDRDIPIAKLDAAAVAYRQGLAHRYG 131 Query: 125 YLIQQATVFGQHVHVGC-------------ASGDD-------AIYLLHGLSRFVPHFIAL 164 ++ + G H +V S D +++ + L Sbjct: 132 R--RRQMLSGVHCNVSLAASLMMGLYQAQTDSRDFTTFQNRCYLHIAQNYLHYRWLLTYL 189 Query: 165 SAASPYMQGTDTRF-------ASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMI 217 SP + S R + G ++ + + + Sbjct: 190 YGCSPSCWPQ-SGLTPPAQPVRSLRNSSSGYTNRPGVTVSYASLNDYCQTLQAAVDNGKL 248 Query: 218 DSIKDLHWDIRPSPHFGT----------VEVRVMDTPLTLSHAVNMAGLIQATAHWLLTE 267 + K+ + +R G +E+R +D ++++ L ++L Sbjct: 249 SATKEFYGQVRLRHAGGHSQLCQDGIQYLELRNLDLNPWAGAGIDLSQLT-CLTWFVLLM 307 Query: 268 RPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGA 327 N QA ++ E V + R LTE +L + + A + Sbjct: 308 LWLPVPASTD-----NWIQAGQHANEQVAIETPMQVTRQLTEG-EQLADALQTMATSLHQ 361 Query: 328 SSAIEALHRQVVSGLNEAQLMRDFVAD 354 A++ + S + A + Sbjct: 362 PHALQVAQHILTSLHDPANTLAARWEQ 388 >UniRef50_C0W6H8 Putative uncharacterized protein n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W6H8_9ACTO Length = 129 Score = 73.0 bits (178), Expect = 1e-11, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 43/97 (44%) Query: 275 KDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEAL 334 N++++ RYG++ ++ G+ +++ +++E++ P A ++G + A+ Sbjct: 1 MPDWYVDENKWRSARYGMDAILITGSDGEEELVSDTVAQMVEQLMPVAEELGCVRELVAI 60 Query: 335 HRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAG 371 + +G + + + A GG+ VK Sbjct: 61 QTTLDAGASYQRQLAAVSAAGGANQAAVKLMQAEVRA 97 >UniRef50_A5LRB7 Glutamyl-tRNA synthetase n=36 Tax=Streptococcus RepID=A5LRB7_STRPN Length = 425 Score = 73.0 bits (178), Expect = 2e-11, Method: Composition-based stats. Identities = 56/420 (13%), Positives = 119/420 (28%), Gaps = 93/420 (22%) Query: 3 LPDFHVSEPFTLGIELEM--------------------QVVNPPGYDL-SQDSSML--ID 39 L + + +GIELE +V DL + Sbjct: 13 LKNIKENPELFVGIELEYPVASLEGDATDVEVIKDLFHYLV--STLDLTVAKVDDFGNLI 70 Query: 40 AVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGT 99 + + I+ + +++ + +E A I + +FS + + + + + I G G Sbjct: 71 QLVDPISQDAILFEVSYTTIEFAFGKAETIQEVEERFSIYMEAIQKKLAESNHAIVGCGI 130 Query: 100 HPFQKWQRQEVCDNERYQRTLEN------------FGYLIQQATVFGQHVHVGCASGDDA 147 HP RYQ ++ + + G V + S + Sbjct: 131 HPNWDKNENCPVAYPRYQMLMDYLNLSRNIIKSDLHHFPEYGTFICGSQVQLDI-SKTNY 189 Query: 148 IYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMP--------WVS 199 + +++ ++ L A S + G D SR + +G P ++ Sbjct: 190 LRVINAFTQIEAAKAYLFANSEF-SGADWDTKISRDIFWEE-SMHGIYPENVGVNARLLN 247 Query: 200 NWQQFEALFR---------------------------------CLSYTTMIDSIKDLHWD 226 + F L+ +I S ++ ++ Sbjct: 248 DEADFFDYLNHSAIFTAERDGQTYYFYPIQAGDYLATPEIQAFALNGDEVIISPQEKDFE 307 Query: 227 IRPSPHF------GTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLY 280 S + GTVE R + T L A L + + ++ Sbjct: 308 THRSYQYQDLTTRGTVEFRSVCTQP-LDRTFASAAFHLGLLVNLDKLEAYLETAPFFKVF 366 Query: 281 KFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSA--HKIGASSAIEALHRQV 338 ++ R + +TD + + E + LL + ++ L ++ Sbjct: 367 GYDYKSLRRQFSKKNLTD---EEETTIIEFSKDLLLLAEEGLVVRNKEEMTYLQPLREEL 423 >UniRef50_B3PGB0 Glutamate--cysteine ligase n=3 Tax=Gammaproteobacteria RepID=B3PGB0_CELJU Length = 536 Score = 72.6 bits (177), Expect = 2e-11, Method: Composition-based stats. Identities = 64/460 (13%), Positives = 111/460 (24%), Gaps = 126/460 (27%) Query: 15 GIELEMQVVNPP-GYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAA 73 G+E E V P + + L A+ T + D +E++LE T + Sbjct: 30 GLEKESLRVTPEASLAQTDHPAGLGSAL----THPHITTDYSEALLEFITQPFTKVEPLL 85 Query: 74 GQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERY-----------QRTLEN 122 Q + + Q + RY R Sbjct: 86 DQLEQIHRFTYQQL-PVGERLWPTSMPCHLGPDD--NIPVARYGTSNSGLMKTIYRIGLG 142 Query: 123 FGYLIQQATVFGQHVHVGCASG--------------------DDAIYLLHGLSRFVPHFI 162 Y T+ G H + + L+ R I Sbjct: 143 HRYGRSMQTIAGIHYNFSLPDSFWQQLQAHVGDQQSLQDFKTERYFALIRNFRRHFWLLI 202 Query: 163 ALSAAS----------------PYMQGTDTRF----ASSRP------------------- 183 L AS P+ DT + S R Sbjct: 203 YLFGASPAVGACFVKRRDHQLQPFPGHQDTLYTPYATSLRMGDLGYQSDAQKSLVVNYNN 262 Query: 184 ----------NIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHF 233 I + P + ++ L L + + IRP Sbjct: 263 LSDYLKTLCGAITQSHPAYERIGVKDTEGNYQQLNTSLLQI-----ENEFYSSIRPKRTS 317 Query: 234 GT---------------VEVRVMDTPL------TLSHAVNMAGLIQATAHWLLTERPFKH 272 VEVR +D T M LL+E P Sbjct: 318 KRGETALQALRLRGVEYVEVRCVDLNPYEPLGITAEQIRVMDSF---LLFCLLSESPAM- 373 Query: 273 QEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIE 332 E+++ + N+ + G + +T +RPL +L ++ G + ++ Sbjct: 374 DEQEFYQGQENQKRVVNQGRDPALTLLSGDTQRPLRLWAGEVLAQMQ------GCAELLD 427 Query: 333 ALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD 372 Q ++ + SL + ++ D Sbjct: 428 QAQSSTAHQQALEQQLQKL--ENPSLTPSAQLLADMQEAD 465 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.310 0.148 0.414 Lambda K H 0.267 0.0459 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,446,573,253 Number of Sequences: 3077464 Number of extensions: 112515701 Number of successful extensions: 447545 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 479 Number of HSP's successfully gapped in prelim test: 385 Number of HSP's that attempted gapping in prelim test: 445027 Number of HSP's gapped (non-prelim): 1395 length of query: 372 length of database: 1,040,396,356 effective HSP length: 130 effective length of query: 242 effective length of database: 640,326,036 effective search space: 154958900712 effective search space used: 154958900712 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 94 (40.7 bits)