BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (653 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteri... 1350 0.0 UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteri... 766 0.0 UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 565 e-159 UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salex... 551 e-155 UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A... 499 e-139 UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei A... 489 e-137 UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 ... 474 e-132 UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ... 473 e-132 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 459 e-127 UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BL... 459 e-127 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 457 e-127 UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_... 451 e-125 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 450 e-125 UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 440 e-121 UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105... 435 e-120 UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE 434 e-120 UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria R... 434 e-120 UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BG... 432 e-119 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 429 e-118 UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS1... 427 e-118 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 424 e-117 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 424 e-117 UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT 422 e-116 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 422 e-116 UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria Rep... 421 e-116 UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermed... 420 e-116 UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii... 400 e-109 UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q... 399 e-109 UniRef50_C6BT42 DNA topoisomerase type IA central domain protein... 393 e-107 UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E... 392 e-107 UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extor... 390 e-107 UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=... 388 e-106 UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria Re... 382 e-104 UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepI... 382 e-104 UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID... 381 e-104 UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 380 e-104 UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum ... 379 e-103 UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria... 375 e-102 UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q4... 367 e-100 UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actino... 366 1e-99 UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria Re... 363 8e-99 UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris... 363 1e-98 UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ... 357 8e-97 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 353 2e-95 UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 ... 352 3e-95 UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum D... 351 4e-95 UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A... 350 8e-95 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 350 1e-94 UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacter... 346 2e-93 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 345 5e-93 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 344 6e-93 UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM... 337 1e-90 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 337 1e-90 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 336 1e-90 UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damsela... 332 2e-89 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 332 3e-89 UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shew... 329 2e-88 UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacte... 325 2e-87 UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepI... 325 3e-87 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 325 4e-87 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 325 5e-87 UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=... 324 6e-87 UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62... 322 2e-86 UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID... 319 3e-85 UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase... 318 4e-85 UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychroph... 318 5e-85 UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales Rep... 318 6e-85 UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_... 317 1e-84 UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q2... 314 6e-84 UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bactero... 313 2e-83 UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0... 313 2e-83 UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tas... 312 2e-83 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 312 3e-83 UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organism... 312 3e-83 UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocell... 311 5e-83 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 311 6e-83 UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp.... 311 6e-83 UniRef50_A5TXI0 DNA topoisomerase TopA n=2 Tax=Fusobacterium Rep... 310 1e-82 UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group... 308 4e-82 UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_... 308 6e-82 UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q0... 307 7e-82 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 307 7e-82 UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q... 307 8e-82 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 307 9e-82 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 307 9e-82 UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6... 305 3e-81 UniRef50_D1AS14 DNA topoisomerase type IA central domain protein... 303 1e-80 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 303 2e-80 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 303 2e-80 UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1... 299 2e-79 UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0... 299 3e-79 UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP... 298 6e-79 UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autot... 296 1e-78 UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0... 295 3e-78 UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostri... 295 5e-78 UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca D... 290 1e-76 UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium haf... 286 1e-75 UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_... 286 2e-75 UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein... 285 3e-75 UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiacea... 285 4e-75 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 284 6e-75 UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID... 284 6e-75 UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamie... 282 3e-74 UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9... 281 4e-74 UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_... 280 2e-73 UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_... 279 3e-73 UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GF... 278 3e-73 UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter prot... 277 1e-72 UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 275 4e-72 UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D... 274 1e-71 UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotubercu... 273 2e-71 UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID... 272 3e-71 UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacter... 272 4e-71 UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans AT... 271 4e-71 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 271 4e-71 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 271 6e-71 UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis... 268 4e-70 UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepI... 267 8e-70 UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A... 266 3e-69 UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytog... 265 3e-69 UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8... 263 2e-68 UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3... 261 4e-68 UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q18... 260 1e-67 UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM ... 260 1e-67 UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL... 259 2e-67 UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID... 258 5e-67 UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=... 257 8e-67 UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LR... 255 4e-66 UniRef50_A5ZNQ6 DNA topoisomerase n=2 Tax=Clostridiales RepID=A5... 254 1e-65 UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C... 252 4e-65 UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=... 251 5e-65 UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus ... 251 6e-65 UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnson... 251 7e-65 UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_... 250 1e-64 UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2M... 249 3e-64 UniRef50_C8L8E9 DNA topoisomerase n=7 Tax=Staphylococcus aureus ... 248 4e-64 UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteob... 248 6e-64 UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesti... 244 7e-63 UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4... 243 1e-62 UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU... 242 3e-62 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 240 1e-61 UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantar... 239 3e-61 UniRef50_C3RPW1 DNA topoisomerase n=1 Tax=Mollicutes bacterium D... 236 3e-60 UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyti... 232 3e-59 UniRef50_B7U5A8 DNA topoisomerase n=2 Tax=Bacillus RepID=B7U5A8_... 232 4e-59 UniRef50_B4U9A2 DNA topoisomerase n=1 Tax=Hydrogenobaculum sp. Y... 230 1e-58 UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus gr... 226 2e-57 UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=... 226 3e-57 UniRef50_C9BIP8 DNA topoisomerase n=1 Tax=Enterococcus faecium 1... 224 1e-56 UniRef50_Q312M7 DNA topoisomerase n=1 Tax=Desulfovibrio desulfur... 223 3e-56 UniRef50_C7H3L1 DNA topoisomerase n=1 Tax=Faecalibacterium praus... 222 4e-56 UniRef50_D1AV52 DNA topoisomerase n=2 Tax=Streptobacillus monili... 221 6e-56 UniRef50_A1VBZ8 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 220 1e-55 UniRef50_B1ZV49 DNA topoisomerase n=1 Tax=Opitutus terrae PB90-1... 217 1e-54 UniRef50_C7X7R3 DNA topoisomerase I (Fragment) n=7 Tax=Bacteroid... 213 1e-53 UniRef50_B7IYV7 DNA topoisomerase n=7 Tax=Bacillus cereus group ... 210 1e-52 UniRef50_A5N5N2 DNA topoisomerase n=4 Tax=Clostridium RepID=A5N5... 207 1e-51 UniRef50_D1NFZ9 DNA topoisomerase III (Fragment) n=20 Tax=Haemop... 204 6e-51 UniRef50_B5K387 DNA topoisomerase III, putative n=5 Tax=Octadeca... 204 7e-51 UniRef50_P40114 DNA topoisomerase 1 n=47 Tax=Bacillus cereus gro... 203 2e-50 UniRef50_C2XKX2 DNA topoisomerase n=7 Tax=Bacillus cereus group ... 201 5e-50 UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium R... 193 2e-47 UniRef50_B1BR51 DNA topoisomerase n=7 Tax=Clostridium perfringen... 188 5e-46 UniRef50_B0MQN7 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 188 5e-46 UniRef50_C7N9L8 DNA topoisomerase n=4 Tax=Fusobacteriaceae RepID... 184 8e-45 UniRef50_D0RWS4 DNA topoisomerase n=1 Tax=Streptococcus sp. 2_1_... 183 1e-44 UniRef50_B0S4M6 DNA topoisomerase n=1 Tax=Finegoldia magna ATCC ... 182 2e-44 UniRef50_A6L0J6 DNA topoisomerase n=13 Tax=Bacteroidales RepID=A... 182 3e-44 UniRef50_A8VW06 DNA topoisomerase n=1 Tax=Bacillus selenitireduc... 181 7e-44 UniRef50_D1NG17 DNA topoisomerase (Fragment) n=3 Tax=Haemophilus... 181 8e-44 UniRef50_P34184 DNA topoisomerase 1 (Fragment) n=1 Tax=Bacillus ... 180 1e-43 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 179 2e-43 UniRef50_D1K8I7 DNA topoisomerase n=1 Tax=Bacteroides sp. 3_1_33... 177 2e-42 UniRef50_C3WQ11 DNA topoisomerase n=4 Tax=Fusobacterium RepID=C3... 176 3e-42 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 171 6e-41 UniRef50_Q8CM28 DNA topoisomerase n=1 Tax=Streptococcus agalacti... 170 1e-40 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 170 2e-40 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 169 4e-40 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 167 9e-40 UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanob... 166 2e-39 UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=... 163 2e-38 UniRef50_Q0W2I3 DNA topoisomerase I n=2 Tax=Euryarchaeota RepID=... 162 5e-38 UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeu... 162 6e-38 UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales Rep... 161 8e-38 UniRef50_UPI000185C839 DNA topoisomerase n=1 Tax=Capnocytophaga ... 160 1e-37 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 160 1e-37 UniRef50_C2H7T8 DNA topoisomerase n=2 Tax=Enterococcus faecium R... 160 2e-37 UniRef50_C0SQM2 Putative DNA topoisomerase n=1 Tax=Lactobacillus... 159 2e-37 UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchae... 159 5e-37 UniRef50_UPI0001C37C64 DNA topoisomerase III n=1 Tax=Ruminococcu... 158 5e-37 UniRef50_A8A8D9 DNA topoisomerase n=1 Tax=Ignicoccus hospitalis ... 157 9e-37 UniRef50_B0UMR5 DNA topoisomerase n=3 Tax=Methylobacterium RepID... 154 1e-35 UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiob... 150 2e-34 UniRef50_A3DID2 DNA topoisomerase n=1 Tax=Clostridium thermocell... 149 2e-34 UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales Re... 149 4e-34 UniRef50_C3ECC9 DNA topoisomerase n=1 Tax=Bacillus thuringiensis... 148 7e-34 UniRef50_Q8TUZ7 Topoisomerase IA n=1 Tax=Methanopyrus kandleri R... 147 1e-33 UniRef50_C8WG68 DNA topoisomerase type IA central domain protein... 147 1e-33 UniRef50_C9RG81 DNA topoisomerase I n=2 Tax=Methanocaldococcus R... 145 4e-33 UniRef50_A2BLA3 DNA topoisomerase n=1 Tax=Hyperthermus butylicus... 145 5e-33 UniRef50_C3NE35 DNA topoisomerase n=9 Tax=Sulfolobus RepID=C3NE3... 144 1e-32 UniRef50_D2EGP7 DNA topoisomerase n=1 Tax=Candidatus Parvarchaeu... 142 4e-32 UniRef50_UPI0001B43857 protein TrsI n=1 Tax=Listeria monocytogen... 142 6e-32 UniRef50_Q64CK3 DNA topoisomerase n=2 Tax=environmental samples ... 141 7e-32 UniRef50_Q5V1P3 DNA topoisomerase I n=1 Tax=Haloarcula marismort... 141 1e-31 UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q... 140 1e-31 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 140 1e-31 UniRef50_A3DP02 DNA topoisomerase n=9 Tax=Desulfurococcaceae Rep... 140 2e-31 UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02... 139 5e-31 UniRef50_Q4J922 DNA topoisomerase n=3 Tax=Sulfolobus RepID=Q4J92... 138 8e-31 UniRef50_Q6N2B4 Possible DNA topoisomerase n=1 Tax=Rhodopseudomo... 137 1e-30 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 136 3e-30 UniRef50_C4GAJ6 DNA topoisomerase n=1 Tax=Shuttleworthia satelle... 136 3e-30 UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1... 135 4e-30 UniRef50_D2RGC8 DNA topoisomerase n=2 Tax=Archaeoglobaceae RepID... 134 8e-30 UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Enta... 134 1e-29 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 133 2e-29 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 131 6e-29 UniRef50_Q702B0 DNA topoisomerase n=1 Tax=uncultured crenarchaeo... 131 8e-29 UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID... 130 2e-28 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 129 3e-28 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 129 3e-28 UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_... 129 4e-28 UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7... 129 5e-28 UniRef50_Q9YB01 DNA topoisomerase 1 n=1 Tax=Aeropyrum pernix Rep... 129 5e-28 UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID... 128 6e-28 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 126 2e-27 UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genom... 126 3e-27 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 125 4e-27 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 125 5e-27 UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=T... 125 6e-27 UniRef50_UPI00006CAF66 DNA topoisomerase family protein n=1 Tax=... 124 8e-27 UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteo... 124 1e-26 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 124 1e-26 UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1... 124 2e-26 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 123 2e-26 UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LV... 123 2e-26 UniRef50_B7G3B1 DNA topoisomerase n=2 Tax=Bacillariophyta RepID=... 122 5e-26 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 122 6e-26 UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q... 122 6e-26 UniRef50_C6A350 DNA topoisomerase I n=3 Tax=Euryarchaeota RepID=... 122 6e-26 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 121 8e-26 UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burto... 121 8e-26 UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanos... 121 1e-25 UniRef50_UPI0001C42CB1 DNA topoisomerase III n=1 Tax=Bacillus ps... 120 2e-25 UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2... 119 3e-25 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 119 4e-25 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 119 4e-25 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 118 6e-25 UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B... 118 7e-25 >UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteria RepID=TOP3_ECOLI Length = 653 Score = 1350 bits (3494), Expect = 0.0, Method: Compositional matrix adjust. Identities = 653/653 (100%), Positives = 653/653 (100%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR Sbjct: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ Sbjct: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY Sbjct: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW Sbjct: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE Sbjct: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP Sbjct: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF Sbjct: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV Sbjct: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF Sbjct: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 Query: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY Sbjct: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 Query: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA Sbjct: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 >UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteria RepID=TOP3_VIBCH Length = 647 Score = 766 bits (1977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/618 (61%), Positives = 469/618 (75%), Gaps = 12/618 (1%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RLFIAEKPSLARAIAD LPKPH+K G I C NG +VTWCIGHLLEQ +PDAYD RY +W Sbjct: 3 RLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 N+ADLPI+PE+WQL+PR S ++QL V+++ L EA++I+HAGDPDREGQLLVDEV+DY ++ Sbjct: 63 NMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKV 122 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K++ VQR LI+DLN AV+RA+ LRSN EF+PL VSALAR+RADWLYG+NM+RAYT Sbjct: 123 PKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYT 182 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI-- 239 +LG+ AGYQGVLSVGRVQTPVLGLVVRRDEEIE+F+ D+F + A I + I Sbjct: 183 LLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRA 242 Query: 240 -WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+PSEAC P+QDEEGR+ +R L ++V +RI+ QPA VT + ++APLP+SLSALQ Sbjct: 243 RWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQ 302 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 I+AAKR+ SAQ VLD+CQ LYE HKLITYPRSDCRYLP+EH A V+ AI+ +A ++ Sbjct: 303 IDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEM 362 Query: 359 LPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 + V D D +R++ W+D KVDAHHAIIPT + +++N L+ +E KVY LIARQYLMQF Sbjct: 363 V-TAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFY 421 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAKGDEL 473 P A++ + + +IA G F+AK R L AGW+ L G ++ EE + PLPV G L Sbjct: 422 PAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPV---GIVL 478 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 C +GE+ +RQT+PPRHFT+ATLL AMTGIARFV DK+LKKILR TDGLGTEATRAGI++ Sbjct: 479 QCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILD 538 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LFKRG L + + I ST AG+ L H+LP AT PDMTAHWE L I+EK YQ FMQ Sbjct: 539 TLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQ 598 Query: 594 PLVGTLYQLIDQAKRTPV 611 L G L QLI+Q + PV Sbjct: 599 TLQGRLEQLIEQVQVAPV 616 >UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=A1U3N5_MARAV Length = 722 Score = 565 bits (1455), Expect = e-159, Method: Compositional matrix adjust. Identities = 323/649 (49%), Positives = 413/649 (63%), Gaps = 17/649 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG---QVVTWCIGHLLEQAQPDAYDSR 57 M L+IAEKPSLARAIA LP PH KG G+I CG G V+WCIGHLLE A+P Y+ Sbjct: 1 MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPA 60 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W + DLP+ PE WQL P+ SV Q V++ + +A I HAGDPDREGQLLVDEVL Sbjct: 61 WKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLR 120 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 YL + V+R LINDL P+AV RAI R N EF PL SALAR RADWLYGIN+T Sbjct: 121 YLGT----KAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLT 176 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP---ADE 234 R YT+ + G QGV SVGRVQTPVLGLVV RD IE+F K ++ V+A AD+ Sbjct: 177 RFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQ 236 Query: 235 R-FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 R F A W P + + + DEE RLL + +AE +V ISG+P + + E PLP S Sbjct: 237 RPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLS 296 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LSALQIEA + + + A++VLD Q LYE H+LITYPRSD RYLPEEHF+ R AV+ AI+ Sbjct: 297 LSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIAR 356 Query: 354 HAPDLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 APDL + R+ W+D+KVDAHHAIIPT R + L+ E K+Y+LI+R YL Sbjct: 357 VAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYL 416 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVVAKG 470 MQF PDAV R+ + + I +F A + E GW+TL + +E +E + PLP + K Sbjct: 417 MQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKN 476 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + +LC + ER+TQPP+HFTDATLLSAMT IARFV D +L+K LR TDGLGTEATRA Sbjct: 477 EPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAA 536 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 II+ LF+R +L ++ R+I +TD GK+L +LPE PD TA WE+ L + + + Sbjct: 537 IIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRA 596 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 F++ L + + QA P PG+ K +A +R K Sbjct: 597 FLESLKDEIRGFMAQA---PAAGLANTETPGTAIHCPKCRAPMVEREGK 642 >UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QVL1_CHRSD Length = 654 Score = 551 bits (1419), Expect = e-155, Method: Compositional matrix adjust. Identities = 302/655 (46%), Positives = 406/655 (61%), Gaps = 27/655 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPSLARAIAD LP ++ +G++ CG ++WC+GHLLEQA PDAYD+RY + Sbjct: 1 MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGE-TCISWCVGHLLEQAPPDAYDARYQQ 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPIVP +W+L PR QL VI++ L A +VHAGDPDREGQLLV +V+ +L Sbjct: 60 WRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R + R L++DLN AV +A+ + N+ + L +A AR+RADW+YGIN++RA+ Sbjct: 120 W----RGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAW 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ GR AGYQGVLSVGRVQTPVLGL+VRRD +IE F + F+ + A + A W Sbjct: 176 TLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVEHGT-LRAWW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QP +A P DE+GRLL R AE + + G ++ KR+++SAPLP+SLSALQ++ Sbjct: 235 QP-QAPHPL-DEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVD 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA+R+ L A+ VLDICQ LYE H+LITYPRSDCRYLPE HFA ++ L Sbjct: 293 AARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRG 352 Query: 361 -QPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCPDA 418 D R+R W+DK+V AHHA+ PT R+ A LT +EA V+ LIAR L QF Sbjct: 353 WYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPL 412 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V R I F A+ R + E GW+ L ++ ++ PLP + +G+ Sbjct: 413 VTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTR-----DEAPPLPALHEGEAARVVDC 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 V +RQT+PP FTDA+L+ AM IAR+V D +K+ LR TDGLGTEATRAGI+E L R Sbjct: 468 AVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 G++ ++ + +T G+AL +LP+ ATRP+ TA WE L I+E + F+ LVG Sbjct: 528 GYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGD 587 Query: 599 LYQLIDQAKRTPVRQ---FRGIVAPGSGGSADKK---------KAAPRKRSAKKS 641 + QL+DQA +RQ G P S K+ ++PR+R+ K + Sbjct: 588 VRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSPRRRAGKST 642 >UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A3EW25_9BACT Length = 684 Score = 499 bits (1286), Expect = e-139, Method: Compositional matrix adjust. Identities = 274/614 (44%), Positives = 375/614 (61%), Gaps = 18/614 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA+VLP PH+KG GF+E G G +VTWC GH+LE A P+ YD ++A Sbjct: 1 MRLFIAEKPSLGRAIAEVLPGPHKKGAGFLETGGG-IVTWCFGHILEAAPPEEYDRKWAA 59 Query: 61 W--NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W + DLPIVP+ W+L P PS QL VI++ L EASEIVHAGDPDREGQLLVDEVL+Y Sbjct: 60 WPGSSGDLPIVPKTWKLSPVPSAKAQLAVIRKLLGEASEIVHAGDPDREGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L R+ V R ++ L+ +AV +A+ LRSN EF + +A R+RADWL G+N++R Sbjct: 120 LG----NRKPVLRIWLSSLDEKAVRQALSGLRSNREFAAMKEAAQVRSRADWLVGMNLSR 175 Query: 179 AYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AY+I R G VLS+GRVQTP L LVV RD EIE+FV+KDFF V+A + P F Sbjct: 176 AYSIAARKNGNPVAVLSIGRVQTPTLKLVVDRDREIESFVSKDFFTVEATLEAPGGA-FK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +W P+E P D GR + R +A V N Q I+ +SE PL ++LS L Sbjct: 235 TVWMPAEN-HPALDAAGRCIDRTVALGVANGTKAQKGIL-DIGKTEKSEPPPLVYALSTL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 ++A+K++ +SA+ VLD Q LYE KL TYPR+DC YLP+ + +++A+ P Sbjct: 293 TMDASKKYAMSAKEVLDTAQSLYE-KKLTTYPRTDCEYLPQTQWGEAREILSALG-RLPG 350 Query: 358 LLPQPVVDPDIR-NRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLIARQYLMQFC 415 L R +R W+ +KV AHH IIPT + A L+E E ++++L+ R+YL QF Sbjct: 351 LSSAASQADSARRSRAWNTEKVTAHHGIIPTREAGRAGGLSEKEVRIFDLVCRRYLAQFY 410 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK--ERDEENDGTPLPVVAKGDEL 473 P + + ++ + F AK + GW+++ G + D + PLP ++ GD + Sbjct: 411 PPFRYTETIVRTRLGGEPFQAKGTTPLDTGWKSVYGPEPDREDRKEPEPPLPALSSGDPV 470 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + VV R+T PP +TD TL++AM + R + + + KKIL TDGLGTEATRA I+E Sbjct: 471 VARDCSVVARKTTPPSPYTDGTLVAAMKNVHRAMSNPEDKKILNETDGLGTEATRASILE 530 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ-DFM 592 LF RG+L K R I ST G+AL ++ + P TA WE L I+ Q +F+ Sbjct: 531 TLFSRGYLEKSKRAIRSTPRGRALIDAVEPIVASPVTTAVWERSLESIATGQGENSGEFL 590 Query: 593 QPLVGTLYQLIDQA 606 +V T+ +L A Sbjct: 591 SKIVDTVSRLTKTA 604 >UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V616_9FIRM Length = 711 Score = 489 bits (1260), Expect = e-137, Method: Compositional matrix adjust. Identities = 285/637 (44%), Positives = 372/637 (58%), Gaps = 21/637 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ RA+A LP PHRKG G+IE G G VVTW GH+L QA+P+ YD R Sbjct: 1 MRLYIAEKPSVGRALATCLPAPHRKGSGWIETGGG-VVTWLFGHVLRQAEPEEYDPALKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+P++W L S +Q V+K + A EIVHAGDPDREGQLLVDEVLD+L Sbjct: 60 WRAEDLPILPKEWHLVVNESAAQQFAVVKGLIARADEIVHAGDPDREGQLLVDEVLDFLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LIN L+ +++ A++ LR N +F+PL +SALARARADWL G+N++RAY Sbjct: 120 ----NTKPVRRILINALDDKSIHDALNDLRDNGDFLPLKLSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGY-QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG+ + VL +GRV+TP L LVVRR+ EIE+F ++ V A T A E F A Sbjct: 176 TLAARRAGHARLVLPIGRVKTPTLALVVRREREIEHFTPATYYLVDALFRTEAGEPFRAR 235 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSLSAL 297 W+PSE P D EGRL+ R A+ PA +VT Y K++ E PLPFSLSAL Sbjct: 236 WKPSEERTPL-DPEGRLVDRAAADAAAASFGEPPADGVVTKYERKKKEEPPPLPFSLSAL 294 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV--HA 355 Q+ A KR+G Q VLD QKLYE KL +YPRSD YLP ++ ++ Sbjct: 295 QVLAGKRYGYEPQQVLDTAQKLYE-EKLTSYPRSDAEYLPVSQHKDAAKILGNLAALSDT 353 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQF 414 P D ++R W+D K+ AHHAIIPT + LT E +Y LIAR Y+ QF Sbjct: 354 PLAAWAQAADSAKKSRAWNDAKISAHHAIIPTTVPVNLARLTAVERNIYELIARAYIAQF 413 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--GSKERD----EENDGTPLPVVA 468 CP+ V+ + E+ F A+ R AGWRT+ G E + E+ + T LP + Sbjct: 414 CPNYVYDQTKAEVTHHGETFTARGRTERTAGWRTMYRAGKNESEDAEKEDEESTVLPPMK 473 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGD E ERQT+PP FT ATLL M I ++V+D+ KK+LR G+GTEATR Sbjct: 474 KGDAAAFVSAETKERQTKPPARFTPATLLQGMKEIHKYVKDEAAKKMLRDVSGIGTEATR 533 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKA--LFHSLPEMATRPDMTAHWESVLTQISEKQC 586 A IIE L +R FL G+ T +A L +LP+ T PD TA WE L +++ Sbjct: 534 ASIIEDLIRRKFLHAAGKKKVLTPTAEAYLLIDALPDTMTYPDATAIWEDQLHAMADGVG 593 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSG 623 ++F+ L D A+ + GI P G Sbjct: 594 TPEEFLAGQAAFARDLCDAARTAQITGGEGIPCPACG 630 >UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 RepID=Q5DY58_VIBF1 Length = 664 Score = 474 bits (1221), Expect = e-132, Method: Compositional matrix adjust. Identities = 263/612 (42%), Positives = 363/612 (59%), Gaps = 19/612 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA L + G+I C NG VVTWCIGHLLE A+P+AYD +Y Sbjct: 1 MRLFIAEKPSLGRAIAASL-GVIKNEKGYITCKNGDVVTWCIGHLLELAEPEAYDKKYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI P++W L P S +QL+V+ + +A+ +V+AGDPDREG LL++EV++Y Sbjct: 60 WSLDTLPIFPKEWILIPTDSSKEQLDVVLEQIKKATVLVNAGDPDREGDLLINEVIEYAN 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ + ++ R LINDLN +A+E A++ L NS+ +P+ +AL R+RADWL G+N+TRA Sbjct: 120 VSNDIKENALRVLINDLNSKAIETALNNLEPNSKRIPISNAALCRSRADWLLGMNITRAC 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++L + G+ VL VGRVQTP + LVV+RD EI NF DFFEV+A T AD F A Sbjct: 180 SVLAKRKGHDNVLHVGRVQTPTIQLVVKRDIEIANFKPVDFFEVEAQF-THADIPFKAKL 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + R+ + LAE ++ I+GQ A VT KR PLPFSL LQ Sbjct: 239 Q----------NKKRIDKKDLAESMITNITGQSATVTLCETKRAKSQPPLPFSLRTLQEA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + ++G A+ LDI Q LYETHK+ +YPR+D YL ++ + L Sbjct: 289 MSSKYGYGAKETLDIAQSLYETHKITSYPRTDKNYLSTIKEDEIQLIIENLEGLNDTPLA 348 Query: 361 QPVVDPD--IRNRCWDDKKVD--AHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 Q D D +R+ CW+DKK++ AH AIIPT R+ ++ L+E E VY IA +YL QF Sbjct: 349 QWASDADMSLRSPCWNDKKLEGSAHTAIIPTTRAPDLDALSEAEHNVYTAIASRYLAQFY 408 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P A I++ + +F + + GWRT+LG ++ D E LP + K + C Sbjct: 409 PTAEDDNTTIKIQSGEHEFKTTGKIEIKKGWRTVLGKEKNDTEEQS--LPSLTKDQSIDC 466 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EV+ ++T P+ +T+ TLLSAM I + V D LK L+ T GLGTEATRAGIIE Sbjct: 467 TNAEVISKKTSAPKPYTEGTLLSAMCNIGKEVTDPALKAKLKETAGLGTEATRAGIIEKA 526 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +R +LT KG+ I ST K L +LP P +TA WE L + +C + F+ + Sbjct: 527 KEREYLTLKGKNIVSTPLAKMLVMALPNKVRDPAITAIWEQQLDVVERGECSVETFINAI 586 Query: 596 VGTLYQLIDQAK 607 T+ L+D K Sbjct: 587 EKTVQSLVDDLK 598 >UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ferrooxidans RepID=B7JBJ6_ACIF2 Length = 699 Score = 473 bits (1218), Expect = e-132, Method: Compositional matrix adjust. Identities = 274/657 (41%), Positives = 380/657 (57%), Gaps = 34/657 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD----- 55 M+L+IAEKPSL + IA+ LP KG+GFI+CG VVTWC GH+ EQ +PD Y Sbjct: 1 MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVP 60 Query: 56 ---SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 +W +LPI PE+W+ + + Q+ VI+ L +AS +V+AGDPDREGQLLV Sbjct: 61 TTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLV 120 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL+ L+ + R + L+ Q+V +A+ L+ N ++ L SA ARARADWL Sbjct: 121 DEVLEELRW----KGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLM 176 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T+ RN+G GV+SVGRVQTP L LVV RDE+IE+F KD++ V Sbjct: 177 GMNLTRAFTL--RNSG-AGVVSVGRVQTPTLALVVARDEKIEHFKPKDYY------VPRI 227 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLP 291 + F A W+ E E D EG L R A+ + +R + A V + + + APL Sbjct: 228 NAGFWATWELREDFEGV-DAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLG 286 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 FSL+ LQ + + G+SAQ+VLD Q LYE HK TYPR+DCRYLPEE +++ + Sbjct: 287 FSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGL 346 Query: 352 SVHA-PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 + DL+ D + ++ W+ KV AHHAIIPT S +++ AKVY++I R Y Sbjct: 347 AKAGFADLVK--AADSNRKSAIWNTGKVTAHHAIIPTG-SMQGSMSPAVAKVYDIIVRSY 403 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP---LPVV 467 L QF P V+R L + A A AGW+ + G D++ND TP +P + Sbjct: 404 LAQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMT--DDDNDDTPAQPIPAL 461 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 KG L + +V +QT+PP FTD +L+ AM+ I + V+D+ K L+ T GLGTEAT Sbjct: 462 KKGQVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEAT 521 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RA IIE L RGFL +KG+ I ST AG+AL H+LP+ T P +TA WE L+ +SE + Sbjct: 522 RASIIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVT 581 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 Q F + + ++I+ AK T V G P SG K + +K+ PA Sbjct: 582 LQQFEEAQRKFVVRMIEAAKATTVAV--GQARPTSGAGRGKSSTGKTRGVGQKTGPA 636 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 459 bits (1181), Expect = e-127, Method: Compositional matrix adjust. Identities = 263/651 (40%), Positives = 367/651 (56%), Gaps = 24/651 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L++ EKPS R I VL R +G++ G G VTWCIGHL+E PD Y + Sbjct: 1 MILYLCEKPSQGRDIGRVLGATSRH-EGYV-AGAGVCVTWCIGHLMEMVAPDGYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPI+P++WQL+ KQ VI+ L +E+V A D DREG+ + EVL+ Q Sbjct: 59 WRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQ 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++ R ++ L+ ++ +A+ L + PL + L R+RADW+ G+N+TRAY Sbjct: 119 Y----RGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAY 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA-HIVTPADERFTAI 239 T+LGR GY GVLSVGRVQTP L LVV RD IENF D+FE+ A H V F A Sbjct: 175 TLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFALHRVHSGT--FIAK 232 Query: 240 W-QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W P + C D EG L R LAE V++++ G +T KR E PLP LS LQ Sbjct: 233 WVPPPKPC----DAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLPLELSTLQ 288 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA++R+G+ A+ L+I Q LYE HK +TYPR+DCRYLP F AV+ ++ + L Sbjct: 289 QEASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASL 348 Query: 359 LPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 P D +R++ W+DKK+ AHHAIIPTA I+ L+ EA +Y+LI R YL QF P Sbjct: 349 TPLVEGADAQLRSKAWNDKKITAHHAIIPTAAKINIDALSREEALLYDLIRRHYLAQFYP 408 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVVAKGDELL 474 + + VI+ +A F A R GW+ +L + + +E D LPVV G+ Sbjct: 409 PFEYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAAT 468 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 E E+ ++QT+PP +T+ TL+ AM + + V+D L+KILR T G+GTEATRA I+E Sbjct: 469 IEGAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILET 528 Query: 535 LFKRGFLTKKG-RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM- 592 L KR L K+G + + S AG+ L +LP T P TA WE L I+ + F+ Sbjct: 529 LIKRNLLAKQGKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLA 588 Query: 593 --QPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 + + L + Q ++ + FRG+ P S D + PR++ K+ Sbjct: 589 KSELWLNKLIHNVHQRQQLGLNPFRGL--PPSTSHTDPAQPTPRRQRRSKA 637 >UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BLQ5_VEIPT Length = 773 Score = 459 bits (1180), Expect = e-127, Method: Compositional matrix adjust. Identities = 266/636 (41%), Positives = 374/636 (58%), Gaps = 39/636 (6%) Query: 1 MRLFIAEKPSLARAIADVLP--KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MRLFIAEKPS+AR I+ LP K +K +G+ G+ VVTW +GH+L QA+P YD +Y Sbjct: 1 MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGD-DVVTWVVGHVLHQAEPGDYDDKY 59 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 RW DLPIVP +W+L S +Q ++K + +A IV+AGDPDREGQLLVDEVL Y Sbjct: 60 IRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + VQR L+N L+ +++ A+D LR N +F L SALARARADWL G+N++R Sbjct: 120 VG----NTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT+ R G + L +GRV+TP L LVVRR+ E+ F D+F VK P + F A Sbjct: 176 AYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHP-NGVFWA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESESAPLPFSLSAL 297 WQP++ + D +GRL+++ +A+ +V ++ SG ++ + ++ + LP SLS+L Sbjct: 235 TWQPTDE-QKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A K F Q VLD QKLYE KL TYPRSDC YLP + R+A++N + + Sbjct: 294 QVLAGKAFSYDPQTVLDTAQKLYE-KKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDE 352 Query: 358 LLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 L Q D D I++R W++KK+ AHHAIIPT + IN L++ E +Y LI++ Y+ QF Sbjct: 353 RLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG---------------SKERDEEN 459 + ++ + I ++ K +FVA R + E GW+ L + ER E+ Sbjct: 413 YGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAES 472 Query: 460 DGTP--------LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 D LP V K D +L V +QT+PP FT +TLL AM I +FV+++D Sbjct: 473 DPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNED 532 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR--YIHSTDAGKALFHSLPEMATRPD 569 LKK L+A G+GTEATRA II+ L RGF+ G+ + T+ G L +LPE PD Sbjct: 533 LKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPD 592 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 TA WE L +SE + F+ + L LID+ Sbjct: 593 ETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDK 628 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 457 bits (1177), Expect = e-127, Method: Compositional matrix adjust. Identities = 253/615 (41%), Positives = 362/615 (58%), Gaps = 20/615 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+++ EKPS AR IA VL K I +G VVTW GHLLEQA PDAYD R Sbjct: 1 MRVYLCEKPSQARDIAAVL-GIQSKDKSSITTADG-VVTWAFGHLLEQAPPDAYDDSLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W LA LPI P +W+++ + S Q I L A+E+V A D DREG+++ E++ ++ Sbjct: 59 WALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +VQR ++ L+ +V++A+ L+ ++E L SAL R+RADWL G+N+TRA+ Sbjct: 119 F----KGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ G + G +GV SVGRVQTP L LVV RD +IE+F +FE+ A + F+ W Sbjct: 175 TLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFF--EAGQSFSTKW 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E D+ GR + + + + V ++I+G+ V+ Y KR SE+ PLPFSLS LQ Sbjct: 233 KVPEGA---GDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKT 289 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FGL AQ VLDI Q LYETHK TYPRSDC +LPEE F +++ A++ D Sbjct: 290 CSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALA--KSDTEV 347 Query: 361 QPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 Q +VD ++ W+ KK+ AHHAIIPT ++ +++NE +VY LI RQYL QF P Sbjct: 348 QGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLP 407 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE-RDEENDG--TPLPVVAKGDEL 473 + + + I + I F + GWR L G + D+E D LP + +G L Sbjct: 408 NYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTL 467 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 E+ +QT+PP +T+ TL+ AM I + + D LK IL+ G+GTEATRAGII Sbjct: 468 PLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIA 527 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L +RGF+TKKG+ + S+D G+ L +LP+ P +TA WE L +I+E + F Sbjct: 528 NLIERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEA 587 Query: 594 PLVGTLYQLIDQAKR 608 +V + +IDQ K+ Sbjct: 588 DVVKFITAIIDQIKK 602 >UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_9FIRM Length = 821 Score = 451 bits (1159), Expect = e-125, Method: Compositional matrix adjust. Identities = 251/625 (40%), Positives = 368/625 (58%), Gaps = 27/625 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ R +A L P + DG++ +G VVTW GH+L QA+P+ YD +Y R Sbjct: 1 MRLYIAEKPSVGRELAKCLTGPVTRRDGYLVTKDG-VVTWLFGHILRQAEPEEYDPKYKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+PE W+L KQ ++K + +A EIVH GDPDREGQLLVDEVLDYL Sbjct: 60 WRADDLPIIPEHWKLFVDKDCEKQFAIVKSLIEKADEIVHGGDPDREGQLLVDEVLDYLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ V+R L+N L+ +++++A LR N +F L SALARARADWL G+N++RAY Sbjct: 120 ----NKKPVRRILLNALDEKSIKKANASLRDNRDFFNLKQSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG++ VL +GRV+TP L LVVRR+ EIE+F ++ ++ + F A Sbjct: 176 TLAARRAGHERLVLPIGRVKTPTLSLVVRREREIEHFKPVTYYLIRG-TFQHENGSFEAQ 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP--AIVTSYNDKRESESAPLPFSLSAL 297 W+P + D E RL+ + +A+ + P A++++Y ++ E PLPFSLS L Sbjct: 235 WKPKDTMAGL-DSENRLIDKKIADEKLAFFEELPHDAVISAYQKAKKQEPQPLPFSLSTL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A KRFG + Q VLD QKLYE KL TYPRSDC YLP +++ ++ Sbjct: 294 QVLAGKRFGYAPQLVLDTAQKLYEK-KLTTYPRSDCEYLPTNQLGEAATILSHLAKAGDA 352 Query: 358 LLPQPV--VDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQF 414 + V +P ++R W+DKK+ AHHAIIPT ++ +T+ E +Y+LIAR YL QF Sbjct: 353 QVAAWVKAANPKQKSRAWNDKKISAHHAIIPTTVQADVTKMTQEERNLYHLIARAYLAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE-----------ENDGTP 463 P + + +E+ F A R + GW+ + S+++ + E Sbjct: 413 YPVHTYDQTKVEVQYKDETFTASGRTERDLGWKVMYQSQKKKQESDEEDDKEDKEESAKT 472 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + K D + ++G ++E+ T+PP FT +TLL+ M I ++V++ + KK L+ G+G Sbjct: 473 LPAMKKKDAVAWQRGRMLEKMTKPPTRFTASTLLAGMKEIHKYVKNPEAKKQLKDVYGIG 532 Query: 524 TEATRAGIIELLFKRGFLTKKG--RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 TEATRA II+ L +R F+ +G +Y+ T A L +LP+ T PD TA WE L + Sbjct: 533 TEATRATIIDDLIRRKFMKAEGKKKYLVPTPAAYLLVDALPDELTYPDSTAIWEDKLHSM 592 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQA 606 SE + DF+Q + +L +A Sbjct: 593 SEGEGSLADFLQGQIAFTRKLCAKA 617 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 450 bits (1157), Expect = e-125, Method: Compositional matrix adjust. Identities = 254/600 (42%), Positives = 353/600 (58%), Gaps = 18/600 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-VTWCIGHLLEQAQPDAYDSRYA 59 M+LF+ EKPS IA VL R G+G + +GQ+ VTW IGHL+EQ P+ YD + Sbjct: 6 MKLFLCEKPSQGNDIAKVLGATKR-GEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFK 64 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 +W LPI+P KW L P+ KQ NV+ + + +A +V A D DREG+ + E+LD Sbjct: 65 KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA 124 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R Q++R ++ L+ ++ +A+ L++N E +PL + LAR+RADWL G+N +R Sbjct: 125 GF----RGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRL 180 Query: 180 YTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+L + GYQG LSVGRVQTP L LVV RD EI+NF+ K F ++ + T Sbjct: 181 YTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQ 240 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS--GQPAIVTSYNDKRESESAPLPFSLSA 296 P + C+P +G L + + +I GQ A V S KRE ++APL F+LS Sbjct: 241 YVIPEQYCDP----DGLCLSAQVIQAANQQIRQFGQ-AKVESVETKRERQNAPLCFALSD 295 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA + +GL AQ VLDI Q LYETHK TYPR+DC YLPE FA ++ + Sbjct: 296 LQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDN 355 Query: 357 DLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 L P +++ + ++R W+DKK+ AHH IIPT + I+ +++ E K+Y+LI R+YL QF Sbjct: 356 RLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQF 415 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVVAKGDEL 473 P + K I L + A+ L GW+ L G K DE++D LP + +G Sbjct: 416 LPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFG-KSLDEDDDAPQALPTLKQGQIC 474 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 E+ QT PP HFT+ TLL+AM ARFV D+ LK+ LR T+GLGTEATRAG I+ Sbjct: 475 QISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQ 534 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L +GFL KKG+ + +TD L +LP+M P +TA WE L QI+E+ + FMQ Sbjct: 535 GLIDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQ 594 >UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6I107_9BACT Length = 739 Score = 440 bits (1131), Expect = e-121, Method: Compositional matrix adjust. Identities = 262/637 (41%), Positives = 380/637 (59%), Gaps = 55/637 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY------ 54 M+L IAEKPS+ARAI DV+ + + VT GH+LE A+PDAY Sbjct: 1 MKLVIAEKPSMARAIKDVVGREYE-------------VTNAFGHILELAEPDAYLPADVP 47 Query: 55 -DSRYAR--WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 + R W DLPI+P +W+ P S QL I L +A +V+AGDPDREGQLL Sbjct: 48 VSIKTGRKIWRACDLPILPAEWRQIPIRSSKDQLIKIGELLKKADLVVNAGDPDREGQLL 107 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 +DE+LD+ + R +V+R ++ L+ ++++A LR N + PL +A+ R+RADWL Sbjct: 108 IDEILDHFRY----RGRVERVWLSALDKTSIDKAFRDLRDNRSYKPLSDAAMGRSRADWL 163 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N+TRA T+ ++G S+GRVQTP L LVV RD IE F A+D+FEV+A I Sbjct: 164 VGMNLTRAATL---SSG--SFYSIGRVQTPTLALVVHRDLAIERFAARDYFEVRARI--- 215 Query: 232 ADER--FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 ER F+A+W+PS+ P DEEGRL R AE + + G ++ Y K ES+SAP Sbjct: 216 RHERGTFSALWKPSDPSGPGFDEEGRLTDRRQAEALSLKGKGA-GKISRYEKKEESKSAP 274 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 LP+SLSALQ A+ RFGLSA VL CQ LYE K+ +YPR+DCR+LP E F+ ++ Sbjct: 275 LPYSLSALQKAASGRFGLSADEVLKTCQSLYE-KKVTSYPRTDCRFLPVEQFSEAGRILQ 333 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 A+ V +PD+ +P++ ++ W+ KV AH AI+PT + +L+E E K+Y++I Sbjct: 334 ALPV-SPDI--RPLISASRKHPAWNTAKVTAHPAIVPTGERAG-DLSEKERKIYDMIVSS 389 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE--ENDGTPLPVV 467 YL F PD + + +++ + + A R + GW L G +R+E E D LP Sbjct: 390 YLALFLPDHRYFSAALSVEMNREIWTATGRQEIDPGWTRLFGRGDREEGGEEDLPSLPEC 449 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G+ +L E GEV E++T+PP FTD TL+ AM+ I +FV+D + K+ L+ T G+GTEAT Sbjct: 450 RPGEAVLGEGGEVREKKTRPPGRFTDGTLIEAMSNIHKFVEDPEAKQTLKETSGIGTEAT 509 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDM-----TAHWESVLTQIS 582 RAGI+E L R ++ +KG+ I ST+ G++L L AT PD+ TA WE L+++S Sbjct: 510 RAGILETLVGREYIVRKGKQILSTEKGRSLVGFL--EATLPDLVDPVTTARWEDDLSEVS 567 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVA 619 + R + F VG + L+ + RT + + +G +A Sbjct: 568 AGKKRVEAF----VGGIADLVREQTRTLLTKGQGGLA 600 >UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105 RepID=A6GUS8_9BURK Length = 670 Score = 435 bits (1119), Expect = e-120, Method: Compositional matrix adjust. Identities = 250/622 (40%), Positives = 365/622 (58%), Gaps = 30/622 (4%) Query: 1 MRLFIAEKPSLARAIADVL------PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY 54 MRLFIAEKPS+ + IA L P K IE G G VVTW GHLLE A P+ Y Sbjct: 1 MRLFIAEKPSMGKEIAKNLGGKMVNQGPAGKPPTHIEVG-GDVVTWGFGHLLEMAPPEHY 59 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+ LPI P+ ++L P+ + Q++ IK L +AS +V+AGDPDREGQ +VD Sbjct: 60 SEAFKKWSFDTLPIEPKSFELLPKSNAKAQISTIKALLKKASTVVNAGDPDREGQWVVDS 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS--EFVPLCVSALARARADWLY 172 +L++ + VQR ++ L+ +V++A+ L+ N+ +F+ SA+ R R+DW + Sbjct: 120 LLEHFG----NTKPVQRIILQALDEVSVKKALANLQPNTSPQFIGWKNSAIGRQRSDWFW 175 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T++ G V+S+GRVQTP LGLVV RD IENF KDF+ V A IV A Sbjct: 176 GMNLTRAHTLVSNVKGQ--VVSIGRVQTPTLGLVVARDLAIENFKPKDFYAVSAQIVG-A 232 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + F+A W+PS+A DE GR+L +A+ V +I Q A VT++ + +SAPLP+ Sbjct: 233 EPVFSAKWKPSDAVP--VDESGRVLDANIAQTVCAKIKSQTASVTAFEAVDKKQSAPLPY 290 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 SLS+LQ+ A+K+ GL AQ VLDI Q LYE KL +YPR+DC YLPE A + + Sbjct: 291 SLSSLQLAASKKLGLGAQRVLDIAQTLYE-QKLTSYPRTDCPYLPESQHASAELIAKCLP 349 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 +L+ I++ W+D KV AHH IIPT + + NL+ A VY++I YL Sbjct: 350 EKYSELVKGASFS--IKSGAWNDSKVTAHHGIIPTGQKA--NLSGELAAVYDMIVLAYLA 405 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 QF P V+++ I L++A KF A + GW+ + GS+E +E D LPV+ G Sbjct: 406 QFYPPFVYKQTTISLEVAGEKFTASGKAPISQGWKVVFGSEESEEGEDKQTLPVLQVGQS 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L+CE +V ++T PP FT+ TL+ AMT + + V D ++KK L+ T G+GTEATRA II Sbjct: 466 LICETAQVDAKKTTPPLRFTEGTLIQAMTNVHQLVDDPEIKKRLKETAGIGTEATRANII 525 Query: 533 ELLFKRGFL------TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 E L R F+ KG+ + ST G+ L LP+ +T +E L +++ + Sbjct: 526 ETLKMRKFIEIPDSGKDKGKLV-STQNGRKLIAKLPDSLKSAGITGLFEQALESVAKGET 584 Query: 587 RYQDFMQPLVGTLYQLIDQAKR 608 FM+ + + ++ A++ Sbjct: 585 SLDVFMEKQTAFVKKYVEMARK 606 >UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE Length = 694 Score = 434 bits (1117), Expect = e-120, Method: Compositional matrix adjust. Identities = 250/608 (41%), Positives = 358/608 (58%), Gaps = 24/608 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS---- 56 MRLFIAEKPS+A+AIA L + KGDGFIECG VTWC GH+LEQA+PD Y Sbjct: 1 MRLFIAEKPSVAKAIASELGQSG-KGDGFIECGT-DTVTWCFGHMLEQAEPDEYTPDDVP 58 Query: 57 RYAR----WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 R AR W + +LPI+P W L+ + +QL VI + L EA+EIV+A DPDREGQLLV Sbjct: 59 RNARGKKIWRVDELPIIPTDWMLKAKDDAKQQLAVIGKLLKEAAEIVNAADPDREGQLLV 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL++ + R R ++ + +V+R + L+ N + +A AR RADWL Sbjct: 119 DEVLEHFRCNKPAR----RFWVSAQDSVSVKRGLAALKDNGTYHGWADAARARQRADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N++RAYT+ + G +G+L+VGRVQTP L LVV RD EIE F + ++A I Sbjct: 175 GMNLSRAYTLRAQRGGSRGLLTVGRVQTPTLTLVVARDREIEAFKPIPYHTIRAAIQHSG 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 F A W+ ++ + D EGRL+ +A+ +V +++G+P V Y + + ++ PL F Sbjct: 235 GA-FLASWR-AKVDQAGLDAEGRLVDTAVADALVAKVTGKPGTVAEYTQEAKKQNQPLAF 292 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS + + A+ +FG SA++VL+ CQ LYETHKL +YPR+DC YLPE A V+ AI Sbjct: 293 ALSDITLLASNKFGYSAEDVLNACQTLYETHKLTSYPRTDCAYLPESQHADSPRVLKAIQ 352 Query: 353 VHAPDLLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQY 410 P+L DP ++++ W+D K+ AHH IIPT + S L E E +Y+LI R Y Sbjct: 353 HVNPELAGLVAGADPRLKSKTWNDSKITAHHGIIPTMHNGSKAGLIERERNIYDLIVRAY 412 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-KERDEENDGTP-----L 464 L QF + + +++ FVA + + GWR + E+D E D L Sbjct: 413 LAQFYCVHEYMSTTVVVEVEDETFVATGKVVTRNGWRDVYQEVDEQDTEKDADEGGNQRL 472 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + KGD + C++ + +T+PP FT+ TLL AM I + V + + KK+LR DG+GT Sbjct: 473 PAMQKGDGVTCKQATRKDAKTKPPARFTEGTLLRAMENIHKVVPEPEHKKMLREEDGIGT 532 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 ATRA II L +RGFL KG+ I T G+++ +LPE+ P +TA +E +L I + Sbjct: 533 SATRASIISELKRRGFLETKGKQIIGTTLGRSMIDALPEVVKSPVLTALYERMLKGIEQG 592 Query: 585 QCRYQDFM 592 F+ Sbjct: 593 TAELAAFI 600 >UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria RepID=Q3BT95_XANC5 Length = 670 Score = 434 bits (1116), Expect = e-120, Method: Compositional matrix adjust. Identities = 247/614 (40%), Positives = 350/614 (57%), Gaps = 21/614 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS + I +L R G+G + G+G VTWCIGHL+E A P+AYD + R Sbjct: 1 MRLFLCEKPSQGKDIGRILGATQR-GEGCLN-GSGVTVTWCIGHLVEAAAPEAYDEQLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W++ LPI+P++WQ++ +P Q V+K L +A+++V A D DREG+L+ E++D Sbjct: 59 WSIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++R ++ LN ++ A+ +LR ++E +P+ SALAR+RADWL G+N++R + Sbjct: 119 Y----RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AGY GVLSVGRVQTP L LVV RD EI FV+ ++ + ++ T + + FTA W Sbjct: 175 TVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTT-SGQAFTAQW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQI 299 + C D+ GR L +P+A+ +I A V S +R E PLPF L LQ Sbjct: 234 ISPDTCT---DDSGRCLQQPVAQQAAQQIRATGSAQVVSVETERVREGPPLPFDLGTLQE 290 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +K+ GL Q LDI Q LYETHK TYPRSD YLPE FA V++ S+ D Sbjct: 291 LCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLD--SLLKTDFS 348 Query: 360 PQPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 +P++D R+R W+D KV AHH IIPT + ++ ++E E VY LI YL QF Sbjct: 349 LRPIIDQLDRTQRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFL 408 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP----LPVVAKGD 471 P F + V L + A + + GWR +L + +E++D LP + +G Sbjct: 409 PHHEFDRTVANLSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGV 468 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 ++ +TQP R +T L+ +M G+A+ V D LK+ L+ T G+GTEATRA I Sbjct: 469 SCQVADVDLKALKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANI 528 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 I L RG+L KKGR I ++DA L ++P P TA WE L I Q F Sbjct: 529 ISGLIARGYLMKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVF 588 Query: 592 MQPLVGTLYQLIDQ 605 + + QLI Q Sbjct: 589 IGKQAAWISQLITQ 602 >UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BGR1 RepID=C5A9D2_BURGB Length = 722 Score = 432 bits (1112), Expect = e-119, Method: Compositional matrix adjust. Identities = 253/657 (38%), Positives = 369/657 (56%), Gaps = 58/657 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+I EKPS+A+A+ LPKPH + +G+ E G+G V+W GH++EQ QP YD R+ + Sbjct: 1 MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDG-YVSWLAGHVMEQVQPGDYDERWGK 59 Query: 61 --WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W+L+ Q+ +I+ L + + IV+ GD DREGQLLVDEVL + Sbjct: 60 FPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLH 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V R ++ ++P +V++AI L N+ F PL + L R RADWL G+NM+R Sbjct: 120 FG----NTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER--F 236 AYTIL + Y GVLSVGRVQ+P L LVV+RD EI+ FV KDF+ V+A P F Sbjct: 176 AYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPF 235 Query: 237 TAIWQPS----EACE--------------------------------PYQDEEGRLLHRP 260 + W P E+ E + DE+ R++++ Sbjct: 236 WSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKA 295 Query: 261 LAEHVVNRI--SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQK 318 +A+ + + +GQ VT Y +K E PLPF L+ LQ ++G SA+ VLD CQ+ Sbjct: 296 VADQIAANVQAAGQ-GTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQE 354 Query: 319 LY-ETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPV-VDPDIRNRCWDDK 376 LY + H TYPRSDC YLP A V++AI+ AP L + IR+R W+D Sbjct: 355 LYLQGH--TTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDS 412 Query: 377 KVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFV 435 KV HHA+IPT ++ + +TE + + Y +IA++YL Q P+ K +E+ IA +F Sbjct: 413 KVTEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFA 472 Query: 436 AKARFLAEAGWRTLLGSK----ERDEENDGTP-LPVVAKGDELLCEKGEVVERQTQPPRH 490 A R + + GWR + + + + D TP LPV+ + + V ++T PP Sbjct: 473 ASGRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPR 532 Query: 491 FTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHS 550 +T+ +LL+AM + R V D +K L+A DG+G ATRAGIIE++ KRGF+ KG+ + + Sbjct: 533 YTEGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVA 592 Query: 551 TDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 T GK L +LP T P MTA WE++L I++KQ FM + +L+ A+ Sbjct: 593 TVVGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAAR 649 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 429 bits (1102), Expect = e-118, Method: Compositional matrix adjust. Identities = 250/618 (40%), Positives = 359/618 (58%), Gaps = 42/618 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY----DSRY 58 + IAEKPS+ARAI + G N +T GH+LEQA+PDAY + Sbjct: 4 VVIAEKPSMARAIRE----------GLGPQANRYEITNAFGHILEQAEPDAYLPGDVPKT 53 Query: 59 AR----WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 A+ W + DLPI+P +W+ P+ QL I L A +++AGDPDREGQLL+DE Sbjct: 54 AKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDE 113 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L++ R +V R + L+ + V +A L SN ++ PL +A AR+++DW+ G+ Sbjct: 114 ILEHFHY----RGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGM 169 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N+TRA T+ + + S+GRVQTP L +VVRRD EIENFV +D+FEV A Sbjct: 170 NLTRAVTVKSGD-----LFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRH-TQG 223 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A W+PS P DEEGRL+ + LAE V + G V + K + +SAPLP+SL Sbjct: 224 AFLAKWEPSSTDGPGFDEEGRLIDKRLAEAVAQKAKGA-GKVARFEAKEQKQSAPLPYSL 282 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 SALQ A+ RFG+SAQ VLD CQ LYE K+ +YPR+DCRYLPEE ++ + + Sbjct: 283 SALQKVASSRFGMSAQQVLDTCQSLYE-KKITSYPRTDCRYLPEEQLVDAPRILGKLPI- 340 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 PD + +P+++P ++ W++ K+ AH+AI+PT A L++ EAK+Y+LI R Y+ F Sbjct: 341 -PDGI-RPLLNPRQKHVAWNNAKITAHNAIVPTG-EPARGLSDAEAKLYDLIWRSYVALF 397 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK--ERDEENDG--TPLPVVAKG 470 PD +R + + + A R + GW+ L G++ E DE+ DG PLPV+ G Sbjct: 398 LPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTG 457 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + + G+V RQT+PP FTD +L+ AM+ I +FV D K L+ T GLGTEATRA Sbjct: 458 DPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRAS 517 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA----TRPDMTAHWESVLTQISEKQC 586 ++E L +R +L KKG+ + ST G+AL L + P TA WE VL ++E + Sbjct: 518 VLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKV 577 Query: 587 RYQDFMQPLVGTLYQLID 604 Q F + + + I+ Sbjct: 578 PMQKFTAAVTQEVAKAIE 595 >UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS155 RepID=A3DB61_SHEB5 Length = 707 Score = 427 bits (1099), Expect = e-118, Method: Compositional matrix adjust. Identities = 233/610 (38%), Positives = 353/610 (57%), Gaps = 15/610 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ IA VL ++GDG G+G VT+C+GH+L+QA+P+ Y+ + Sbjct: 1 MRLFLCEKPSQAKDIASVLG--CKRGDGVFT-GDGIAVTFCVGHVLQQAEPENYNPDFET 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ DLPI+P W++ P Q ++K+ L +A+E++ A D DREG+++ EVL+Y+ Sbjct: 58 WNIVDLPIIPTVWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYVN 117 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +QR ++ L+ ++++A+ LR N E L + L R+R DWL G+NMTR Sbjct: 118 Y----KGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLC 173 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R GYQG SVGRVQTP L LVV RD ++E F + ++++ + A F A W Sbjct: 174 TLLSREYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYDITG--LFNATIPFKAKW 231 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + DE+GR L +HV+++ QP VT ++ KR+ P F L +LQ Sbjct: 232 QVPDN---LGDEQGRCLQVTTVDHVLSQCRDQPGTVTQFDTKRQKSKHPPLFFLGSLQKA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FG A+ VLDI Q LYE +K+ TYPR+DC YLP ++++ + V Sbjct: 289 MSAKFGYGAKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVVPAFAAW 348 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAV 419 D + + CW+DKK+ AHH IIP + ++ + E E +Y+ I ++YL QF P A Sbjct: 349 CSAADVNETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAE 408 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVVAKGDELLCEKG 478 IEL + A + GWR + G DE D + LP+++ G + L + Sbjct: 409 DDATTIELMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDSANLPLLSIG-QTLTAQF 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 + +++T+PP FT+ TL+ AM+ IA+F D LK IL+ T G+GTEATRA II+ L R Sbjct: 468 QREDKRTKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKAR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 GF+T G+ + S++AG++L +LP++ TRP MTA WE L +I+ DFM Sbjct: 528 GFVTVTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTF 587 Query: 599 LYQLIDQAKR 608 + QL+ K+ Sbjct: 588 ITQLVSMFKQ 597 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 424 bits (1090), Expect = e-117, Method: Compositional matrix adjust. Identities = 233/619 (37%), Positives = 354/619 (57%), Gaps = 21/619 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L+I EKPS A+ +A V+ K ++GDGF+ G +V+TW GHLLE PD YD RY Sbjct: 1 MDLYICEKPSQAKDLAGVM-KASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI PE W+ R S KQ +++ + +AS I + D DREG+ + +LD + Sbjct: 60 WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++R + L+ ++++A++ ++ + V L +ALAR RADWL G+N++R Y Sbjct: 120 YS----GPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R+ G+ L VGRV TP + LV +RD EI F ++ + + V+ + +F A W Sbjct: 176 TVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVN-VSVQNGQFAAQW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P E C DE+GR +++ AE V ++++G A+++ K ESAPLPF L++LQ Sbjct: 235 IPPEEC---SDEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLPFDLTSLQQY 291 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+KR+G +AQ VLD Q LYETHK TYPR+D RYLPE ++ A+ + ++ Sbjct: 292 ASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSG 351 Query: 361 QPV-VDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 DP + R ++D KV AHHAIIPT AR+ ++E E +Y+ I R Y+ QF + Sbjct: 352 LVAGADPHRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEF 411 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS------KERDEENDG----TPLPVVA 468 F K IE+ + F + + + GW+ L S K+ E+ D LP V+ Sbjct: 412 EFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVS 471 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L E+ + T+P HFT+ATLL+AM IARFV ++ K+IL+ T GLGT ATR Sbjct: 472 QGEPALLNGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATR 531 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A II+ +G+ ++ + + +TD AL LP P MTA WE L +++ Sbjct: 532 ASIIQGAVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNM 591 Query: 589 QDFMQPLVGTLYQLIDQAK 607 FM+ + + Q+++Q K Sbjct: 592 SVFMKQISTWICQMVEQLK 610 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 424 bits (1089), Expect = e-117, Method: Compositional matrix adjust. Identities = 249/628 (39%), Positives = 363/628 (57%), Gaps = 30/628 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LF+ EKPS A+ IA V+ H++ D F + GNG V W GHLLEQA+P+AY +++A Sbjct: 1 MKLFLCEKPSQAKDIARVI-GAHQRRDNFFQ-GNGVQVAWARGHLLEQAEPEAYGAQFAA 58 Query: 61 -WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 W + LP++PE+W++ + IK+ L +A+E+V A D DREG+++ E+L+ Sbjct: 59 PWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLE-- 116 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 A R++VQR ++ L+ ++ +A++ L + L + L RARADWL G+NMTR Sbjct: 117 --ACHYRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRL 174 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ R G+ G+LSVGRVQTP L L+VRR+ EI +FV+K F+ V A + F A Sbjct: 175 FTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGI-IFQAH 233 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHV--VNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 W+P+ Y D+E R +H A+ V + R +G+ A V + N+ + PLPF L L Sbjct: 234 WRPASQ---YCDDEHRCIHVQAAQAVEQLCRQAGK-ATVCTVNETKGKALPPLPFDLGTL 289 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP- 356 Q A++R+G SA VL+I Q LYE HK TYPR+DC YLP A V++A+S P Sbjct: 290 QQAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPA 349 Query: 357 --DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQ 413 ++L Q + P +R W+D K+ AHHAIIPT ++ +N + E E VY LI YL Q Sbjct: 350 LQNVLAQ--LQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQ 407 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD----EEND-----GT-P 463 F PD + + LDI +FVAK + GW L E D EE + GT Sbjct: 408 FLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEAGTET 467 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + +G+ + ++ +VV+ T PP+ +TD TL++AM + F+ D LKK+L+ GLG Sbjct: 468 LPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLG 527 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISE 583 TEATRAGII L R + ++ + + +TD G L +LP T P MTA WE L Q+++ Sbjct: 528 TEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQ 587 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 FMQ + L LI + P+ Sbjct: 588 GNLSLDVFMQKQISWLAHLIKKGGEMPL 615 >UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT Length = 737 Score = 422 bits (1085), Expect = e-116, Method: Compositional matrix adjust. Identities = 246/591 (41%), Positives = 343/591 (58%), Gaps = 27/591 (4%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RL IAEKP LA+AI + L RK DG+ ECG+ +V TWC GH+L P+ YD RYA W Sbjct: 5 RLVIAEKPELAKAIVEGLGGGSRK-DGYYECGSDRV-TWCYGHMLALLDPEDYDERYANW 62 Query: 62 NLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 N+ADLPIV W+ +P Q I L +A +VHAGDPD EGQLLVDE+L+Y Sbjct: 63 NMADLPIVHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPDDEGQLLVDEILEYA 122 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR LIND N + V R + +R N EF L +A AR+ D LYG N+TR Sbjct: 123 NC----RLPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVGDQLYGFNITRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 YT+ R GYQG+LSVGRVQTP+LGLVVRR E ++ V + F A Sbjct: 179 YTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQFEVEGIQ-FPAR 237 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 +Q ++ +P DE+GRL ++ AE + +SGQPA + S K + +APLP++L LQ+ Sbjct: 238 YQVADG-DPV-DEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLPYNLLKLQM 295 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A+++FG V DI Q L E HKLITY RSDC YL EE V+ AI+ AP L Sbjct: 296 DASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAIAQTAPMLA 355 Query: 360 PQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 +P I++R ++ KV AHHAIIPT ++ ++ LT+ E K+Y LIAR Y+ QF P Sbjct: 356 AAAQRANPTIKSRAFNSSKVSAHHAIIPTESTADLSKLTDAEQKIYLLIARAYVAQFWPK 415 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP------LPVVAKGD 471 ++ + + + +F ++ GW+ L + +E+ +G L + G Sbjct: 416 HLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDIEQDLRKLRDGQ 475 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLG 523 C + +++T+P +T +LLS +T +A++++D L+KIL D G+G Sbjct: 476 AGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKDKGKQGEHGGIG 535 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHW 574 T ATR II LF+RG+L +KG++I ST G+ L+ +LP+ A PDMTA W Sbjct: 536 TPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARFPDMTALW 586 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 422 bits (1084), Expect = e-116, Method: Compositional matrix adjust. Identities = 248/648 (38%), Positives = 376/648 (58%), Gaps = 26/648 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ I VL + DG+ + G+ +VTW GH+L QA PDAY +YA Sbjct: 1 MRLFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGD-TIVTWAFGHILTQAAPDAYGEQYAD 59 Query: 61 W-NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + N++ LPI+PE WQ+Q P V+KQ VIK L +A E+V A D DREG+++ E+LDY Sbjct: 60 FGNISALPILPEVWQMQVPPKVSKQFKVIKSLLAKADEVVIATDADREGEVIAREILDYC 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R+++ R + L+ Q+V++A+ + + L + LAR RADWL G+N++RA Sbjct: 120 GY----RKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLARGRADWLVGMNLSRA 175 Query: 180 YTILGRNAGY--QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 YT +AGY + +LS+GR+QTP L LVV+RD+EI+ FV +++ + T FT Sbjct: 176 YTA-AYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTLSVDFETADKSVFT 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +WQ E +++ +G + + +V ++ V + N +R+S PLP+SLSAL Sbjct: 235 TLWQ---VPENWRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTPPPLPYSLSAL 291 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA K+ GLSA VL I Q LYE +K+ +YPR+ CRYLP+ + V AI Sbjct: 292 QKEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDVFAAIQTIDKS 351 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVD--AHHAIIPTARSSAINLT---ENEAKVYNLIARQYL 411 +L DP+ ++R W+D +V+ +HHAIIPT ++S +L+ +NE VY +I +Y+ Sbjct: 352 MLSVIEKADPERQSRVWNDNQVNKHSHHAIIPT-KASNFDLSVLDKNELTVYRMIRDRYI 410 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK--ERDEENDGTPLPVVAK 469 QF PD + V+E++ F A ++ +GW+ LLG E D+ ++G LP + Sbjct: 411 AQFYPDFEYDSTVVEVEACSHLFKASSQSPVISGWKVLLGKDVFEGDQIDEGPALPHLKV 470 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF---VQDKDLKKILRATDGLGTEA 526 DE+ ++T PP FT+A+LL M + F V+D+ ++KIL++T+GLGTEA Sbjct: 471 NDEVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRKILKSTEGLGTEA 530 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 TRA II+ LF+ G++ KK I++T+ G+ L +P M P TA WE L I + Sbjct: 531 TRATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTMIADPITTAKWELALAGIEAGKL 590 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 +FM + +L+ QAK+ V + R S G+ KK+A R Sbjct: 591 TLAEFMAYQQKVITELVGQAKKDAVGKARPPKQTDSAGT--KKQAVAR 636 >UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria RepID=A4JFS2_BURVG Length = 760 Score = 421 bits (1082), Expect = e-116, Method: Compositional matrix adjust. Identities = 238/628 (37%), Positives = 361/628 (57%), Gaps = 26/628 (4%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG----QVVTWCIGHLLEQAQPDAY--D 55 RLFIAEKP++AR IA + K G++E G +V CIGHLL+QA+P Y D Sbjct: 3 RLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYVKD 62 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 + ADLPI+P++W+LQ + Q+ +++R L E E+V+AGDP REGQL++DE+ Sbjct: 63 LEFPG-TFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDEL 121 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L++ R+ V+R L+N L+ V+R + L+ N+ F P+ + L R RADWL G+N Sbjct: 122 LEFCG----NRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGMN 177 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 ++RAYTILGR A Y+GVLSVGRVQ+P L LVVRRD IE FV +D++ VKA + E Sbjct: 178 LSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGE- 236 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 F A W+ E + DEEGR++ + AE +V GQ +T + K E LPFSL+ Sbjct: 237 FWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSLA 296 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQI A+ ++G SA+ VLD CQ LY K +YPR+D R+L A ++AI+ Sbjct: 297 TLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQTL 356 Query: 356 PDLLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQ 413 L P D I + WDD KV H+A+IPT+ ++ +LT + +Y +A++Y+ Sbjct: 357 SMLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYITL 416 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG------------SKERDEENDG 461 F PD + + +E +A+ F A R + GWR + K +E+ D Sbjct: 417 FYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKEDE 476 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 P ++ G + +++T+PP +D++LL AMT + + V+D L++ L+++ G Sbjct: 477 QRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSKG 536 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 +GT ATRA IIE L ++G L ++G+ + S+ A + L +LP P ++A WE+ L + Sbjct: 537 IGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDLV 596 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRT 609 + + FMQ L QL+++A+ T Sbjct: 597 AAGKAPLDLFMQKQEAWLRQLLEKAQAT 624 >UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermedia K12 RepID=C7HY28_THIIN Length = 723 Score = 420 bits (1080), Expect = e-116, Method: Compositional matrix adjust. Identities = 249/605 (41%), Positives = 353/605 (58%), Gaps = 34/605 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-VTWCIGHLLEQAQPDAYDSRYA 59 MRL IAEKPS+A+AIADV+ R+GDG+I+C + VTWC GHLLEQA+P+ Y Sbjct: 1 MRLIIAEKPSVAQAIADVIGGV-RRGDGYIDCPQAKTRVTWCFGHLLEQARPEDY-VNGG 58 Query: 60 RWNLADLPIVPEKWQLQPRPS-VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + + LP++P W+L PR KQ+ I+ L +A+E+V+AGD DREGQLLVDEVL + Sbjct: 59 KVLASHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAGDADREGQLLVDEVLLF 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + + R ++ L+ ++V RA+ ++SN PL SALAR RADWL G+N + Sbjct: 119 LNW----KGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQRADWLMGMNASI 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A + + G QG SVGRVQTP L L+V R +I+NF +D ++V+A + D A Sbjct: 175 ALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQATL----DGDIRA 230 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +WQ E Q ++G LL + AE + GQ A V ++ K AP+P++LS LQ Sbjct: 231 LWQIPE---DLQTDDGLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPYALSTLQ 287 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A+ R GLSA++ L Q+LYE KL TYPRSDC +LP E A ++ A+ Sbjct: 288 KTASSRLGLSAKDTLAAAQELYEA-KLATYPRSDCPWLPVEMHAAAAQIIRALGAA---- 342 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA--INLTENEAKVYNLIARQYLMQFCP 416 +DP+ R+ W+ KV+AHH IIPT R A L+EN K+Y L+ YL F P Sbjct: 343 -EMAGIDPERRHPAWNTAKVEAHHGIIPTGRGLAEVSGLSENAKKIYGLLRESYLRLFMP 401 Query: 417 DAVF--RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP----LPVVAKG 470 F R+ + A+ +F A AR + E+GW T LG + E+D T LP++ +G Sbjct: 402 PETFETREALFTFPGAE-RFKASARIVQESGW-TQLGQADNSAEDDETGQVARLPILTEG 459 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 +L CE +V+ ++T PP+ +TD TL++AMTG+ + V D LK L+ T GLGTEATRA Sbjct: 460 QQLACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRAS 519 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 +IE+L R + +K + IH T+ G L L ++A P TA E L I+ + Sbjct: 520 MIEVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARST 579 Query: 588 YQDFM 592 + +FM Sbjct: 580 FDEFM 584 >UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii LLAP12 RepID=C6N6E9_9GAMM Length = 668 Score = 400 bits (1027), Expect = e-109, Method: Compositional matrix adjust. Identities = 238/625 (38%), Positives = 351/625 (56%), Gaps = 19/625 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFI EKPS A+ IA VL R D E GN VTWC+GHLLE A PD Y Sbjct: 1 MRLFICEKPSQAKDIATVLGATTRT-DACFE-GNEIAVTWCVGHLLELAPPDHYCDSIKP 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W + LP+VP++W L P+ KQLN I + L +A +V A D DREG ++ EVLDY Sbjct: 59 WRMEVLPVVPKQWVLMPQEKTKKQLNAIGKLLKQARSVVIATDADREGDVIGREVLDYFN 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R ++ L+ +++++A+ ++ + L + L R RADWL G+N+T A Sbjct: 119 Y----QGPVERLWLSALDEESIKKALHSIKPGAATECLYQAGLGRQRADWLMGMNLTMAV 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L G QGVLSVGRVQTP L LVV RD IE F A+D++ +KA E F W Sbjct: 175 SSLYALPG-QGVLSVGRVQTPTLKLVVDRDLGIEQFKAQDYYVLKALCENINQEPFWVTW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 E E D++G+ + + + V +I+G+ VTS+ + + E+ PL SLS+LQ Sbjct: 234 ---EIPEELSDDDGKCIQKASIDEVARKINGKAGRVTSFKELDKREAPPLCLSLSSLQQL 290 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+ + GLSA++ LDI Q LYE HK +YPR+DC YLP+ FA AV +A+ P++LP Sbjct: 291 ASSQLGLSAKHTLDIAQALYEQHKATSYPRTDCGYLPDSQFAEAGAVFDALKQIDPEVLP 350 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPTA--RSSAINLTENEAKVYNLIARQYLMQFCPD 417 ++++ W+ K+ AHH IIPT + + +TE+E VY LI YL QF + Sbjct: 351 LIERCSLQLKSKAWNSDKITAHHGIIPTLNPKVNLKTMTESERNVYQLIRAYYLAQFLGE 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS----KERDEENDGT-PLPVVAKGDE 472 F + + LDI F A A GW++ + +E + + D + +P + + Sbjct: 411 YEFVQRQVTLDIEAYTFKASAHLPGVLGWKSAIKPIRDLEEEELDTDASESIPKLHDQEP 470 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + R+T+P FT+ +L++AM IA ++++ LKKIL+ T G+GTEATRA I+ Sbjct: 471 VSIQKLKPDSRKTKPKSRFTEGSLIAAMKSIANYIENPQLKKILKETSGIGTEATRANIL 530 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E L R +L ++G+ + ST G+ L LP+ T P TA WE +L I+ + DF+ Sbjct: 531 ETLLSRAYLKRQGKQLISTPKGRELIQRLPQSITNPATTALWEQMLEDIALGKHALDDFL 590 Query: 593 QPLVGTLYQLIDQ-AKRTPVRQFRG 616 + TL ++ Q K+ P G Sbjct: 591 EEQSDTLSGMLVQLEKQKPASHILG 615 >UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q9F544_ECOLX Length = 718 Score = 399 bits (1025), Expect = e-109, Method: Compositional matrix adjust. Identities = 244/654 (37%), Positives = 366/654 (55%), Gaps = 40/654 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP++A I L + DG+ E N +VT C GH++E P+ Y+ Y Sbjct: 1 MKLFIAEKPAVANDIVKALGGNFTRHDGWFESDN-TIVTNCFGHIIESQPPENYNPEYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDY 118 W + LP+ + QP S KQ+ I + A +EI+HAGDPD EGQLLVDEVL+Y Sbjct: 60 WKIETLPLRLYPVKYQPVESAEKQVKTIIELIRRADVTEIIHAGDPDDEGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R LIND AV++A+ ++N +F L + ALAR+ AD +YG++MTR Sbjct: 120 AG----NTKPVKRVLINDNTLPAVKKALANPKNNRDFRGLYLKALARSVADAIYGLSMTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI + GY+GVLSVGRVQTPVLGL+V R +N + ++ + H AD A Sbjct: 176 AYTIPAKTKGYKGVLSVGRVQTPVLGLIVNRTRANKNHKSSFYYTMTGHFQRGAD-VIRA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+P E P D +LL + A ++G+PA V + + +APLPF+L LQ Sbjct: 235 NWKPGEFA-PLTDR--KLLDKTWANGTATSLAGKPATVEAAATDDKKTAAPLPFNLVRLQ 291 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 K+F ++AQ LDI Q+L E +K ITY RSDC YL +E F+ +++A+ + Sbjct: 292 QYMNKKFKMTAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQIIDALK----SV 347 Query: 359 LPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 QP+ +D +++ ++ KV AH AIIPT +N L+ +E VY IA+ YL+QF P Sbjct: 348 FDQPMDIDTTRKSKAFNSAKVTAHTAIIPTVSVPDVNALSTDERNVYLAIAQHYLVQFMP 407 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK-----ERDEENDGTPLPVVAK-- 469 + +++ + + F A+AR ++G+ LG + E + END + ++ K Sbjct: 408 EKAYQEVSVAIQCGDESFYARARKTTDSGFEAFLGVENAGDDEAEVENDDSDFDLLCKIR 467 Query: 470 -GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD-------- 520 G+ + ++ V E++T PP FT+ATLL+A+ +A FV D +KK+L+ D Sbjct: 468 TGETVTTKEVVVNEKKTTPPPLFTEATLLAALVRVADFVTDPVIKKLLKEKDRDKKDEHG 527 Query: 521 GLGTEATRAGIIELLFKRGFLT-KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLT 579 G+GT ATRA I+E L KR ++T +KG+ I TD G AL +LP++A PDMTA W T Sbjct: 528 GIGTPATRASILETLKKRNYITLEKGKLI-PTDTGYALIDALPDIAVNPDMTALWAEKQT 586 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAP 633 I + + F+ L L +I A ++ V+P + ++ ++P Sbjct: 587 LIENGEMTIEQFVDELYNDLIPMISNANSAEIK-----VSPSAPSGQSQRLSSP 635 >UniRef50_C6BT42 DNA topoisomerase type IA central domain protein n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BT42_DESAD Length = 720 Score = 393 bits (1010), Expect = e-107, Method: Compositional matrix adjust. Identities = 238/622 (38%), Positives = 350/622 (56%), Gaps = 27/622 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEK +A AI+ L P R + NG +TW GH+L P+ +D RY Sbjct: 1 MRLFIAEKRDVALAISQALGGPDRPTGAAFQV-NGDRITWLWGHVLRLTDPEEHDERYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL---HEASEIVHAGDPDREGQLLVDEVLD 117 W+L LP+ KW + P +K ++ +K+ + H+A E+V+AGDPD EGQ LVDEV++ Sbjct: 60 WDLNTLPM---KWPVTYAPE-SKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIE 115 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + L + +R LIND N A+ +A+ + +NS++ L +SALARA D YG N+T Sbjct: 116 FAGLL---EKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLT 172 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R Y+ L + GYQGVLSVGRVQTP+LGLVV RD E + + VKA I P+ + Sbjct: 173 RCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPS-QLVE 231 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + P++ + DE+GR+ + + N + GQPA V S PLP++L AL Sbjct: 232 AEYIPAD--DAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLAL 289 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q +AA + + VL+I Q+L + HK ITY RSDCRYL +E A ++ A++ D Sbjct: 290 QADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGD 349 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 + P+++++ ++ KKV AHHAIIPT + L E+E ++Y LI + Y+ QF Sbjct: 350 M--AEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYL 407 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTP-LPVVAKGDELL 474 A F +EL IA KF A+ R + GWR L +D E+ + P L + + D Sbjct: 408 PAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGT 467 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGTEA 526 E E V+ T+PP +T +LL +T +A++V D ++KK+ D G+GT A Sbjct: 468 VESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPA 527 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 TR IE LF+RGF+ +K + + ST+ G+ +LPE A +PDMTA W QI + Sbjct: 528 TRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGEL 587 Query: 587 RYQDFMQPLVGTLYQLIDQAKR 608 Y ++ + G++ Q I + KR Sbjct: 588 NYLQLIEEVDGSVAQEIARVKR 609 >UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9A9_9BACT Length = 645 Score = 392 bits (1006), Expect = e-107, Method: Compositional matrix adjust. Identities = 238/630 (37%), Positives = 358/630 (56%), Gaps = 43/630 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+AR +A L ++G I+ NG +V W GHLLEQA+P AY ++AR Sbjct: 1 MRLYIAEKPSVARLLAATLGDGKQEGQ-HIKLTNGDIVAWAAGHLLEQAEPAAYGDQWAR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ LPI+P++W++ R V I+ L +A+E+V+ GD DREGQLL+DE+L + Sbjct: 60 WNIDSLPILPQQWKMNVRSEVKDLFKSIQGDLKDATEVVNVGDADREGQLLIDEILQRCR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LI D + A+ + N +A AR+RADWL+G+N TRA+ Sbjct: 120 Y----KGPVKRLLITDTTETGIRNALASMTPNEAHRGAAQAAQARSRADWLHGMNGTRAF 175 Query: 181 TILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L + GY+G L +GRV+TPV LVVRRD EIE+FV K ++ +KA + P+ ++A+ Sbjct: 176 TCLAQKGGYRGNALRIGRVKTPVTALVVRRDLEIEHFVPKPYWVLKAQVSVPSG-TYSAV 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W+P+E + D++ RL+ + + +V R++G A V S K PL +SL LQI Sbjct: 235 WKPTED-QVGLDDQNRLIDPTVRDDLVARLNGAKAEVQSVEVKHCKAVPPLGYSLPRLQI 293 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A+KRFGLS + L ICQ LYE +++TYPRSDC Y PE A+ + A D+L Sbjct: 294 DASKRFGLSPEATLKICQGLYEA-QMLTYPRSDCVYAPE-----------ALKLSAEDVL 341 Query: 360 PQPVVDPDIRNR------------CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 D+ R W+ KV H+AI+PTA + L+ +E K+Y L+ Sbjct: 342 LACGKVTDLVGRFKGGLSLSRTAPVWNTAKVAEHYAILPTACPAPKALSSDEKKIYELVV 401 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS----------KERDE 457 +YL F D + + +I I F +K + + GW+ L K +E Sbjct: 402 TRYLAFFMSDYEYEQTLIVTTIDGETFHSKGKRELQQGWKVLTAKVEDEDDSEEKKSEEE 461 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E + LP + +GD + ++++T+ P+ FT+A+LL+AM GI +FV ++KKIL+ Sbjct: 462 EEEDQALPELKQGDSGTASV-QSLDKETKAPKRFTEASLLAAMNGIHKFVSSPEIKKILK 520 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 TDG+GT AT+A II L G L K+ + I S+ + +AL +LPE T PDMTA WE Sbjct: 521 ETDGIGTAATQAKIIADLETSGLLIKEKKSITSSPSARALIAALPERITLPDMTALWEMK 580 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 Q+ + ++ + + G + +ID+ K Sbjct: 581 FRQLETGKATFESVLDEITGEIVGMIDEVK 610 >UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B550_METEA Length = 888 Score = 390 bits (1002), Expect = e-107, Method: Compositional matrix adjust. Identities = 241/608 (39%), Positives = 349/608 (57%), Gaps = 24/608 (3%) Query: 2 RLFIAEKPSLARAIADVLP-----KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS 56 RLFIAEKP+L RAIA L +P G GFIE G G VTW IGH + A+P Y S Sbjct: 4 RLFIAEKPALGRAIATALATLSGARPS-AGRGFIEVG-GDCVTWTIGHAYDTAEPGDYSS 61 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + +W+L LP++PE+W+L P + Q+ V+K + V+ GD +REGQL+VDE+L Sbjct: 62 TWDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYDHFVNVGDAEREGQLIVDEIL 121 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + P +V R ++ + V A+ NS+ L +A+AR RADWL G+NM Sbjct: 122 IENGVDPFS-PKVSRVWVSSFVEKDVAAAVAGAFPNSQKKSLYEAAVARQRADWLLGMNM 180 Query: 177 TRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 +R + ++ + +G +G +SVGRVQTP L LVV RD +IENF A D F V + Sbjct: 181 SRVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENFKAVDHFAPSITFVH-ENGT 239 Query: 236 FTAIWQ-PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A WQ P++ D EGRLL + +A+ +V +I+G+ V SY++ +S S PLPF+L Sbjct: 240 FKAAWQFPADT--KGLDPEGRLLDKAVAQALVQKIAGKTGTVESYSETPKSTSPPLPFAL 297 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE-HFAGRHAVMNAISV 353 S LQ +++FGL+AQ LD+ Q+LYE HK ITYPRSD ++LP H ++ ++ Sbjct: 298 STLQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPNSVHTDEADGILRNLAG 357 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT---ENEAKVYNLIARQY 410 +P +++ +DDKKV HH IIPT+ +SA L E E KV+ LIAR + Sbjct: 358 VRELADAAGRANPKLKSPAFDDKKVTDHHGIIPTSEASASKLAAMGEIERKVFLLIARTF 417 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG--SKERDEENDGTPLPVVA 468 + QF PD + + +F A + + GW+T+ G + +EE +GT LP + Sbjct: 418 VAQFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAEEADEEEEAEGT-LPSMK 476 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 D + + G + ++T+PP HF D TL+ AM I +VQD++++K LR DG+GTEATR Sbjct: 477 MKDPVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEVRKRLRENDGIGTEATR 536 Query: 529 AGIIELLFKRGFLTK----KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 A +IE L + +L + K + + STDAG+ L LP PD TA WES L ++ Sbjct: 537 ASMIEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLPSDLVAPDTTAMWESFLERVKGG 596 Query: 585 QCRYQDFM 592 + FM Sbjct: 597 EFTLAQFM 604 >UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=A1TJM5_ACIAC Length = 680 Score = 388 bits (997), Expect = e-106, Method: Compositional matrix adjust. Identities = 243/658 (36%), Positives = 343/658 (52%), Gaps = 37/658 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+ + EKPS + IA VL R+ G G VTW IGHL+E A P+AY + R Sbjct: 1 MRVVLCEKPSQGKDIARVLGARQREAGCL--AGPGIKVTWGIGHLIEAAPPEAYGEHFQR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPIVP++W+ + Q V++R L +ASE++ A D DREG+++ E+++Y Sbjct: 59 WSLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R +QR ++ LN ++ +A+ LR++ E +PL ALAR+ ADWL GIN+TR + Sbjct: 119 Y----RGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AG+ GVLSVGRVQTP L LV RD EI FV F+ ++ + A + F+A W Sbjct: 175 TLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLSAGA-QAFSAHW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVN--RISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P D GR L + A+H R +G A VT + +R E PLPF LS LQ Sbjct: 234 VPPATV---TDAAGRCLQQSAAQHAAAAVRTAGH-AQVTGIDTERVQEGPPLPFDLSTLQ 289 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 ++R GL Q LDI Q LYETHK TYPR+D YLPE V+ ++ P L Sbjct: 290 EVCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPAL 349 Query: 359 LP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 P +D R+R W+ K+ AHHAIIPT + ++ ++E E VY LI YL QF P Sbjct: 350 QPLMQRLDLGQRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLP 409 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--------GSKERDEENDG-----TP 463 + + ++ L A + + +AGW+ G++ + E D Sbjct: 410 HYAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQA 469 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + +G ++ T+ P +T L+ AM +A+ V D LK+ LR T G+G Sbjct: 470 LPTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIG 529 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISE 583 TEATRA II L RGFL +KGR + ++ L ++P P TA WE L I Sbjct: 530 TEATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEA 589 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 + F+ + QL++Q + +R G P G AA RKR+ K Sbjct: 590 RTMDLDTFVSKQAAWVSQLVEQHREATLAIRVPAGPPCPLCG-------AATRKRTGK 640 >UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria RepID=B1VJ64_PROMH Length = 772 Score = 382 bits (982), Expect = e-104, Method: Compositional matrix adjust. Identities = 236/631 (37%), Positives = 359/631 (56%), Gaps = 41/631 (6%) Query: 1 MRLFIAEKPSLARAIADVL---PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 MR+FIAEKPSLA+AI + L P +K G+ + G+ VVTWC+GH+LE + P YD + Sbjct: 1 MRVFIAEKPSLAKAIFEGLGGNPNTEKK-KGYFQHGD-DVVTWCVGHMLELSDPQDYDEK 58 Query: 58 YARWNLADLPI---VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 YA W DLPI P ++++ + Q +I + +A IV+AGDPD EG LLV+E Sbjct: 59 YASWRFGDLPIKTVFPPTYKIKKETAA--QTKIILSLIDQAKTIVNAGDPDEEGCLLVNE 116 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +LDY + ++ V+R L++DLN V++A+ L+ N +F + SAL+R+ D +G Sbjct: 117 ILDY----AKNKKPVERILVSDLNLAPVKKALADLQPNEKFRGMSNSALSRSLLDQSFGY 172 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N+TR T+ GR GYQGVL+VGRVQ+ VLGLV R +N ++++ A ++ Sbjct: 173 NLTRGCTLKGREKGYQGVLNVGRVQSAVLGLVNMRTLANQNHNESFYYDIYA-LIEMNGH 231 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + A +Q ++ + D++ RL+ A+H+ +SGQ VT K E+ PLP +L Sbjct: 232 QVKAKYQTTDNDQI--DDKRRLISEAQAKHITEIVSGQAVKVTIAATKAENTKPPLPLNL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S LQ AKRFG + Q LDI Q LYETHKL+TYPR+D RYL +EH+ + + A+ Sbjct: 290 STLQQICAKRFGYAPQETLDIMQSLYETHKLLTYPRTDNRYLSDEHYYQANDIAQAVIGT 349 Query: 355 APDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLM 412 P+L +D +++ ++ K++AHHAI+PT + S I L E E VY L++ ++ Sbjct: 350 LPELASTVEHMDKVQKHKAFNASKIEAHHAIVPTTKDGSNIQLNEKEKNVYRLVSLYFIG 409 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP------LPV 466 F PD++ K + DI F A L ++GW +L K+ DEE P L Sbjct: 410 LFYPDSIRDKTKVHFDIKGNTFTATQSVLVQSGWESL--GKDSDEEETEEPEKLDFDLST 467 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD------ 520 + D +CE V ++ T PP++FT +TLL+AMT A+F+ D +L+KIL A D Sbjct: 468 LKFNDNGVCETANVDKKPTLPPKYFTASTLLAAMTRAAKFIDDPELRKILEAKDEGSTDQ 527 Query: 521 -GLGTEATRAGIIELLFKR-GFLT--KKGRYIH----STDAGKALFHSLPEMATRPDMTA 572 +GTEATRAGI++ L + G ++ K+ Y +T G+ +LP+ T+PD++A Sbjct: 528 GSIGTEATRAGILKKLSENTGLISIEKEKGYSELVWKTTKQGQEFCAALPDEITKPDISA 587 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 W I + + DF++ + +LI Sbjct: 588 RWAEKQALIKKGELTVADFIKETDSYIKELI 618 >UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepID=A1WZY5_CAMJJ Length = 730 Score = 382 bits (980), Expect = e-104, Method: Compositional matrix adjust. Identities = 218/618 (35%), Positives = 350/618 (56%), Gaps = 39/618 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L ++ G+G+I+ G+ +VTW GH+LE A+P+ YD +Y Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNYKSGEGYIQKGDN-IVTWAFGHILELAKPEEYDEKYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W L DLP+ ++++ P+ KQL +I +H + + IV+ GD D EGQ+LVDE++ Y Sbjct: 60 WKLEDLPLPIKEFKYLPKKESKKQLKIICDLIHSDKITSIVNCGDADDEGQILVDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + + V R LINDL P+AV+ I +++ N++F + AR++ADW+ GIN+TR Sbjct: 120 SKTS----KPVFRVLINDLTPKAVKEEIAKIKPNADFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI+ R GY+G+LSVGRVQTP+L L+V RD+E ENF + +++ + Sbjct: 176 AYTIMARKNGYEGILSVGRVQTPILALIVNRDKEFENFKSINYYSLLGDFNI-------- 227 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + E ++L LA+ + Q A + + + + E PLP++L LQ Sbjct: 228 ---NNNTIKARLKTEDKILDENLAKEIKESCENQNAKI-NLKIENKKEYPPLPYNLLVLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI--SVHAP 356 E AK FG S L+I Q L E HK ITY RSDC+YLPE F ++N I ++++ Sbjct: 284 AECAKLFGFSPDKTLEITQILREKHKAITYNRSDCQYLPETMFEQAPNILNIIKENLNSN 343 Query: 357 DLLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 D + + D I+++ ++D + AH+ IIPT + LT++E VYNLIA+++++QF Sbjct: 344 DEIQALIASSDLTIKSKAFNDANISAHYGIIPTQNKISSQLTQDELVVYNLIAKRFIIQF 403 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-----KERDEENDGTPLPVVAK 469 ++ I L++ + F A ++G+R+L + ++ + END L ++ Sbjct: 404 FHPREYQTTTINLEVNQRIFTATQNKTTKSGFRSLWQNIDSEEEQENNENDINDLSILKN 463 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 GD C ++ ++QT+P ++T TLL + +A++V D+ +KK+L D G Sbjct: 464 GDIAKCSLIQIEKKQTKPRPYYTMTTLLKDLNSVAKYVSDERIKKLLIEKDKDKKGESGG 523 Query: 522 LGTEATRAGIIELLFKRGFL---TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 +GT ATR+ I+ L +R ++ K + I ST G+ L P+ PDMTA W Sbjct: 524 IGTPATRSNHIKTLIEREYIEVSKDKKQIIKSTKKGRDLIKLSPKSLITPDMTALWFEQQ 583 Query: 579 TQISEKQCRYQDFMQPLV 596 I + R + F++ + Sbjct: 584 KMIEISELRREQFLEEIT 601 >UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID=C9Q4L2_9VIBR Length = 736 Score = 381 bits (978), Expect = e-104, Method: Compositional matrix adjust. Identities = 241/647 (37%), Positives = 355/647 (54%), Gaps = 39/647 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKP--HRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MR+FIAEKPSLA AI L K +G+ + G VVTWC+GHLL P+ Y+ + Sbjct: 1 MRVFIAEKPSLAAAIFKGLGGDVNTEKKNGYYQHGQ-DVVTWCLGHLLALCDPEDYNIEH 59 Query: 59 ARWNLADLPI---VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 +W L+ LP+ P + L+PR KQL V+ ++ +A+ IVHAGDPD EG LL+DEV Sbjct: 60 KKWALSYLPLETMYPPR--LKPRKGAEKQLKVVLEWIGKATSIVHAGDPDPEGCLLIDEV 117 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L Y + VQR LI DLN + V+ A+ L+ N F+PL ALAR+ AD +G N Sbjct: 118 LQYAN----NTKPVQRVLIADLNDKPVKAALANLQPNENFLPLTQKALARSIADQTFGYN 173 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 +TRAYT+ R G+ VL++GRV T ++G++ R +N ++E+ H + A Sbjct: 174 LTRAYTLKAREKGFDDVLNIGRVITAMIGMINERTLANQNHQKSFYYELFGHF-SVAGNT 232 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 A P E E DE+GR++ + A++ S K ES +APLPF+LS Sbjct: 233 IKAKLIPDEHFE--LDEQGRMISSLEVAATKEADTNASAVIQSVEQKEESRAAPLPFNLS 290 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV-- 353 LQIEA+KR+G + VLD Q LYE HKL+TYPRSD ++L + H + AI Sbjct: 291 KLQIEASKRWGYKPKEVLDALQALYEKHKLLTYPRSDNQFLSDAHLENAPQIFAAIQGTM 350 Query: 354 -HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYL 411 H D + Q P ++ ++ K++AHHAI+PT +S A I L E + +Y LIA++++ Sbjct: 351 PHLSDAVTQAT--PTSTHKAFNAAKIEAHHAIVPTEKSGAGIELNERKKNLYELIAKRFV 408 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVVAKG 470 F PDA K + ++ + A L GW L + DE N L + +G Sbjct: 409 ALFYPDAKRSKVMADIACTGRIYRATQTTLTTQGWEVLFKGEHNDEPNQNLIDLSTLTEG 468 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GL 522 E C ++ ER+T+PP++F DA+LL AMT A+F++D L+K L A D + Sbjct: 469 AEARCSHLDMEERETKPPKYFDDASLLKAMTQAAKFIKDPVLRKTLEAKDKDTAGENGSI 528 Query: 523 GTEATRAGIIELLFKRGF---LTKKGRYIH----STDAGKALFHSLPEMATRPDMTAHWE 575 GTEATR+G IE + K LTK+ Y + +T+AG+ LP+ RPD++A WE Sbjct: 529 GTEATRSGHIEKVGKLTHLVTLTKEKGYKNPVYKTTEAGQEFCALLPDEIVRPDISAIWE 588 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR--TPVRQFRGIVAP 620 L +I++++ + F+ + + +D K P + +G+V P Sbjct: 589 GSLNKIAKREESIEAFLHSVNHYIATQVDHVKTQGVPFSKRQGMVCP 635 >UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AY08_RUBXD Length = 701 Score = 380 bits (976), Expect = e-104, Method: Compositional matrix adjust. Identities = 231/638 (36%), Positives = 344/638 (53%), Gaps = 37/638 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL +AEKPS+ R IA L + R+GD + G+G VVTW +GHL E A PDAY + Y R Sbjct: 1 MRLIVAEKPSVGRDIAGALGRHRREGDALV--GSGWVVTWALGHLAELAPPDAYGAEYKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W+L +LPI+PE+++++ P ++ ++R++ + S E+V+A D REG+L + Y Sbjct: 59 WSLQNLPILPERFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACDAGREGEL----IFAY 114 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + V+R ++ L P+A+ LR PL +A +RA ADW+ G+N TR Sbjct: 115 LYQLSRCEKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRAEADWIVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AY++ G VLSVGRVQTP L L+V R+ EIE+F + FF V A + Sbjct: 175 AYSVRFSRPG--DVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARFARDGKT-YDG 231 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +W ++++E RL R AE + ++ G +V +R SE PL + L+ LQ Sbjct: 232 LW--------FREKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDLTELQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A R+G +A+ L Q LYE KLITYPR+ RYL + + A P+L Sbjct: 284 RNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAG-GLPEL 342 Query: 359 LP-----QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 P + R DD KV HHAI+PT R + L +EAKVY+L+AR++L Sbjct: 343 APFAGRLLAAGSLPVGRRVVDDSKVTDHHAIVPTDRKPSGGLPPDEAKVYDLVARRFLAV 402 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL----LGSKERDEENDGTPLPVVAK 469 F P A F + + F++K R + EAGWR L +G + +E + LP V Sbjct: 403 FFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGR---KEKEPPALPPVEA 459 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G E K V E +T+PP ++++ LL AM + V+D++L++ ++ + GLGT ATRA Sbjct: 460 GQEWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDS-GLGTPATRA 518 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDMTAHWESVLTQISEKQCRY 588 IIE L K G++ ++ + + T G+AL L + + P+MTA WE L +I + R Sbjct: 519 AIIERLIKVGYVEREKKALVPTAKGRALISLLADSPLSSPEMTARWERRLARIERGEERR 578 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 DFM + G +++ +R + I APG GG A Sbjct: 579 PDFMSDISGFAASVVEGVRRM---EGEKIAAPGGGGEA 613 >UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum EbN1 RepID=Q5NX65_AZOSE Length = 634 Score = 379 bits (974), Expect = e-103, Method: Compositional matrix adjust. Identities = 232/615 (37%), Positives = 336/615 (54%), Gaps = 32/615 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPSL +AIA+ LP + DGFI G VVTW GH+LE A P+AY+ + Sbjct: 1 MRLYIAEKPSLGKAIAENLPGVKSRDDGFIRVGT-DVVTWAHGHILELAPPEAYNPAWKS 59 Query: 61 WNLAD--LPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 WN A LP E ++L P+P QL VI+ L +A+E+V+AGDPDREGQ+L+DE+L+ Sbjct: 60 WNTAVNVLPYPIECFKLLPKPDSKAQLRVIQSLLSQATEVVNAGDPDREGQMLIDEILE- 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + R LIN +P V++A+ +R NSEF L +A R+ ADW+ G+N+T Sbjct: 119 ---SSAWKGPTLRLLINATDPVTVKKALSSMRPNSEFFNLYQAAKCRSEADWIIGMNLTV 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A T L N ++SVGRVQTP L LVVRRDE IE F A+ FF ++ + TP Sbjct: 176 AATKLLAN---DELVSVGRVQTPTLALVVRRDEAIEKFGARPFFSLEVTLETPQGP-IVL 231 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + PS DE R+ A+ +V + + ++ + + ES P F L Q Sbjct: 232 TYNPS-------DESKRIWSEVDAKRIVEEVKQRQSVTVTVTTGIKKESPPRLFMLRTFQ 284 Query: 299 IEAAKRFGLSAQNVLDICQKLYET-HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 E R+G SA L++ Q LY++ H+L +YPR+DC Y+P + I Sbjct: 285 GECNSRYGWSASKALELAQSLYDSKHQLASYPRTDCEYMPAGQANDALTIAQHIVKQTSF 344 Query: 358 LLPQPVVDPDI-RNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFC 415 P++ + R +D KV HHA+ PT +S+ LT +E K + L+A ++LM Sbjct: 345 TAFAPLLSLAVPRASIYDSSKVTEHHALTPTVKSADFKTLTADEQKAWLLLAERFLMSLL 404 Query: 416 PDAVFRKCVIELDIAKGKFVAKARF---LAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 P + V+ + +F AK +A++ WR L + PLP VA G Sbjct: 405 PSHQIEETVVSFSHGEIEFSAKGEVSLNMAQS-WRALAPHTYK-------PLPQVADGAT 456 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L VV+ +T PP+ +T+ TLL M+ +A++V+D LK IL+ T G+GT AT+A II Sbjct: 457 LQMAGLRVVKGKTTPPKRYTEKTLLDDMSSVAKYVEDPKLKAILKETSGIGTAATQAKII 516 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E L +RG++ K R + ST G+A+ H LPE T P +TA WE L I+ + D+M Sbjct: 517 ETLKERGYVAVKNRELISTPFGRAVVHGLPERLTDPCLTALWEDALGLIAAGGMKPGDYM 576 Query: 593 QPLVGTLYQLIDQAK 607 + G QL+D + Sbjct: 577 LRVRGMCKQLVDDVR 591 >UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria IOP40-10 RepID=B1F998_9BURK Length = 690 Score = 375 bits (963), Expect = e-102, Method: Compositional matrix adjust. Identities = 235/613 (38%), Positives = 347/613 (56%), Gaps = 32/613 (5%) Query: 2 RLFIAEKPSLARAIADVLP-KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY---DSR 57 RL+IAEKPSLA+ + V +P R G + + G G GH+L QA PD Y D Sbjct: 3 RLYIAEKPSLAKDVMAVFDGRPSRNGPAY-KVG-GDFFVPLKGHILAQAMPDFYLPDDVP 60 Query: 58 YAR-----WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 R W +DLP++P W LQP+ L+ I++ L E+VH GDPD EGQLLV Sbjct: 61 LNRNGNKIWRASDLPVIPSTWILQPQEEHASILDAIRQLLANVDEVVHLGDPDAEGQLLV 120 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADW 170 DEVL+YL V+R L+N+ NP + +A+ LR+N E F ALAR+R DW Sbjct: 121 DEVLEYLG----NTLPVKRLLVNNNNPNEIRKALANLRNNDEPEFRAWHRWALARSRYDW 176 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 L+G+N TRA T ++ G+ +LSVG VQTPVL +V RD++IE F +F + A + Sbjct: 177 LFGLNFTRAATCRAQSLGFDALLSVGSVQTPVLQIVFERDDKIERFKPTSYFLLSAQL-Q 235 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 A FTA W+ ++ + DE+GRL+ +A + ++ PA V+++ K + APL Sbjct: 236 HAKGAFTAKWRAADD-QLGLDEDGRLVDPDVAAALAQSLTNAPATVSAFERKPARDLAPL 294 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 P SL+ L +EA +RFG +A VLD Q+LY+ +KL TYPR++ RYL E A Sbjct: 295 PLSLNELTVEACRRFGCTAAEVLDAAQELYDRYKLTTYPRTENRYLAEAQH--DEAPDAL 352 Query: 351 ISVHAPDLLPQPVVDP---DIRNRCWDDKKVDA--HHAIIPTARSSAIN-LTENEAKVYN 404 ++ A P+VD +R+R +DD+K+D HH I+PTAR + ++ LT + +VY+ Sbjct: 353 AALAANRADLAPLVDRADLTLRSRAFDDEKMDGDPHHGIVPTARRADLSTLTPLQHQVYD 412 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 LI R YL+QF P A F + IE++ + +A R +GW +L E + ++D L Sbjct: 413 LIVRYYLVQFYPAATFMQTSIEVESGGNRLIAGGRTPVSSGWLAVLKPSEPETDDDVQML 472 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P +A GD+LL ++ ++T+PP F +ATL+ AM + ++ D K L+A G+GT Sbjct: 473 PQLAVGDQLLVIDVDLQAKETRPPARFDEATLIDAMIDLHKYTDDPAAKARLKAGKGIGT 532 Query: 525 EATRAGIIELLFKRGFLT----KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQ 580 ATRAGII +RGFL K R++ S A +AL +LPE P + ++ L Sbjct: 533 SATRAGIIAEHRERGFLVPVKGSKTRFMTSPTA-RALLAALPEPVKDPTVAGMFKIALDA 591 Query: 581 ISEKQCRYQDFMQ 593 +++ + + FMQ Sbjct: 592 VADGEMTFDAFMQ 604 >UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q48AZ8_PSE14 Length = 721 Score = 367 bits (942), Expect = e-100, Method: Compositional matrix adjust. Identities = 227/616 (36%), Positives = 331/616 (53%), Gaps = 31/616 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+FIAEKP+L + IA+ L RK DG+ ECG+ +VTWC+GHLL A P+ ++ Y Sbjct: 1 MRVFIAEKPALGQVIAEALGTVIRK-DGYFECGSNNIVTWCVGHLLALAPPEVHNPAYKD 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL- 119 W ADLP+ QP QL V+++ + ASEIVHAGDPD EGQLLV+EVL+Y Sbjct: 60 WVQADLPLKLRPAMYQPIARTRDQLKVVQQLIGRASEIVHAGDPDDEGQLLVEEVLEYFG 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 AP V+R LIND+N A +A++ LR N EF L ALAR+ D LYG NMTRA Sbjct: 120 NTAP-----VKRILINDMNANAARKALEGLRDNREFYGLYQKALARSIGDQLYGFNMTRA 174 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ GR G + VLSVGRVQTP+LGL+V R ++ + ++ V A + + Sbjct: 175 CTLAGRAKGVKSVLSVGRVQTPILGLIVNRYLANKSHASTFYYSVAASLAVGGHRAQARL 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++A P D++ R++ A +V + +PA V + + APLPF+L LQ+ Sbjct: 235 VVATDA--PL-DDKNRIIDEVYATNVADACRQKPAAVIEARVEEKQTPAPLPFALLDLQV 291 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +K + A+ L + Q L E +K ITY RSDC YL E F ++ +S PDL Sbjct: 292 YMSKTHSIDAEKTLALTQALREKYKAITYNRSDCSYLTAEQFGEAPQTLSLLSEALPDLA 351 Query: 360 PQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 V+ + ++R +DD KV AH AIIPTA I L+ +E VY I ++Y+ QF P+ Sbjct: 352 GMFTEVNSERKSRAFDDSKVSAHTAIIPTAVKIDITQLSADERAVYMAIVKRYVAQFLPE 411 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK-------- 469 + + + FVA++ + GW T ++E + + DG+ VA Sbjct: 412 KRYLSAEVRFGVNGHTFVARSTKVTHPGW-TAQVTEENEPDEDGSDAAEVASPFDALAGL 470 Query: 470 --GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD------- 520 GD +C+ V + +T+P +T+A LL + +A++V+D +K++L D Sbjct: 471 KVGDAGVCDGITVAKEKTKPLPLYTEAELLKDLRRVAKYVKDPRIKQLLIDRDQGKKGEN 530 Query: 521 -GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLT 579 G+GT ATR ++ L +RGF + + + T G +LP +AT PDMTA W Sbjct: 531 GGIGTPATRGAVLAKLQERGFYAVEKKKLIPTALGLEFIAALPAIATTPDMTALWHEQQQ 590 Query: 580 QISEKQCRYQDFMQPL 595 I + F+ L Sbjct: 591 MIEAGELTVDAFLDEL 606 >UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actinomycetemcomitans D11S-1 RepID=D0UIR3_AGGAD Length = 760 Score = 366 bits (940), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 213/624 (34%), Positives = 340/624 (54%), Gaps = 20/624 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKP LA+ IA+ + +RK G+ EC N VVT IGH+L Q P+ + +Y Sbjct: 1 MKLIIAEKPQLAQVIAEAIGIINRKT-GYFECNNNYVVTNAIGHILMQKMPEEINEQYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L DLP+ L+ +P +Q V++ L +A +++AGDPD EGQLLVDE++++ Q Sbjct: 60 WRLEDLPLQVRPIPLKVKPQTAEQFKVVQGLLAQADTVINAGDPDDEGQLLVDEIIEFCQ 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + QR L+NDL ++ ++A+ + NS+++ + ALAR++AD+++G+N+TRAY Sbjct: 120 F----KGVQQRLLVNDLKVESAKKALANIEPNSKYLGMRNKALARSQADYIFGLNLTRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TI R G + L VGRVQTP L LVVRR + + ++ V + T F A Sbjct: 176 TIFARKKGIKNALMVGRVQTPTLALVVRRFLQNRDHKESYYYNVGGNF-TFNQTSFNAKL 234 Query: 241 QPSEA--CEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +E +P ++E R++ +A + + +++ + ++ SAPLPFSL LQ Sbjct: 235 VLTENIPTDPNNEKEKRIIEEAVANGIKTACEAKNVTLSTVTIEDKTTSAPLPFSLLDLQ 294 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++G S+ VL I Q L E HK ITY RSDCRYL ++ F ++ ++ P+ Sbjct: 295 VRLNNKYGFSSDKVLKITQDLREKHKAITYNRSDCRYLTDDQFNEAPQTLDFLTDLFPE- 353 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 LP+ +D + R ++ KV AH AIIP +N T++E KV+ IA QY +QF P+ Sbjct: 354 LPKEQIDKTKKGRAFNANKVTAHTAIIPVTGKYQLNDFTQDELKVFTEIATQYFIQFLPE 413 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVVAKGDELLC 475 +++ + +F A GW L+ + +EEN D L + + + C Sbjct: 414 KSYQQVTAIVACNGYQFKTTATKTLNHGWSKLVADDDVEEENQSDFEQLASLTEQAQGQC 473 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGTEAT 527 + E+ + +T+P +T+ATLL + I+++V+D D+KK+L D G+GT AT Sbjct: 474 NRIEIKKEKTKPLPIYTEATLLKDLQNISKYVKDPDIKKLLIDKDKGKDGENGGIGTPAT 533 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 R+ II+ L G++ +G+ I TD SLP++ T PDMTA W +I + Sbjct: 534 RSAIIKKLVDTGYIEYQGKKILPTDLAIDFIGSLPDIITYPDMTALWFEQQREIEQGNLS 593 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPV 611 F+ + + + I QA+ V Sbjct: 594 VNSFLDRIEKFVMEQIKQAENLKV 617 >UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria RepID=Q4L0S6_HAEIN Length = 750 Score = 363 bits (933), Expect = 8e-99, Method: Compositional matrix adjust. Identities = 215/629 (34%), Positives = 336/629 (53%), Gaps = 26/629 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKP L IA+ + RK DG+IEC G VTW IGH+LE +P+ + Y Sbjct: 1 MRLVIAEKPQLGAVIAEAIGIVGRK-DGYIECKGGYNVTWAIGHVLELKEPNEINPAYKN 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN DLP+ +L+P+ + KQ +I+ L +A +V+AGDPD EGQLL+ E+L+Y Sbjct: 60 WNAKDLPLKLRPMELKPKANTEKQFRIIESLLKKADTVVNAGDPDDEGQLLIREILEYTG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R L+NDLN +A +A+ L+ +SEF + ALAR+ AD+++G+N++RAY Sbjct: 120 F----KGTVERLLLNDLNVEAARKAMKNLKPDSEFDGMYYKALARSHADYIFGMNLSRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA-- 238 T+ R G V S+GRVQTPVLGL+VRR +N ++ + + + D+ A Sbjct: 176 TLSAREKGLDSVYSIGRVQTPVLGLIVRRYLANKNHKESFYYNLSGNF-SFQDKTLNARL 234 Query: 239 IWQPSEACEPYQDE--EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 + + + +P +E E R++ +A+++ + + ++ APLPF+L Sbjct: 235 VITDNISTDPNDEESKEKRIIDENIAKNIQKDCEKHTVNIIQCGIEAKTTPAPLPFALLD 294 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ + ++G SA L I Q L E H+ ITY RSDCRYL E F ++ +S P Sbjct: 295 LQAKINDKYGFSADETLAITQSLREKHQAITYNRSDCRYLSTEQFEAAPKTLDFLSGLFP 354 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQ 413 + LP D ++R ++DKKV AH IIP N L++ E KVY I QYL+Q Sbjct: 355 E-LPFNSADRSRKSRAFNDKKVTAHTGIIPVVSDKFSNISALSDKEQKVYRAIVEQYLVQ 413 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK---G 470 F P+ + + + + +F A + + GW L+ D END ++A Sbjct: 414 FLPEKQYDLASVTIQCSDYQFRTSATKITDHGWSKLVPDDAED-ENDNAKFDLIASLQAD 472 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GL 522 +CE E+ + +T+P +T+ATLL + +AR+++D +KK+L D G+ Sbjct: 473 ASGMCESVEIKKEKTKPQPIYTEATLLKDLQRVARYIEDPRIKKLLIEKDKGREGENGGI 532 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQIS 582 GT ATR+ +I+ L +GF +G+ + T G +LP + T PD TA W I Sbjct: 533 GTPATRSAVIKNLHDKGFFEYQGKKLIPTQKGIDFIEALPRIVTVPDTTALWFEQQLAIE 592 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 + + +F+ + + + I+ AK + Sbjct: 593 KGELSVDEFLDEIEKFVGEQIEAAKNVKL 621 >UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris pv. vesicatoria str. 85-10 RepID=Q3BZV2_XANC5 Length = 728 Score = 363 bits (932), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 239/700 (34%), Positives = 368/700 (52%), Gaps = 64/700 (9%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY---- 54 +L++AEKPS+ +A+A L K P G G+ V W GH+ + A+PD Y Sbjct: 4 FKLYVAEKPSVGKALAGHLAKSAPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERT 63 Query: 55 --------DSRYARWNLADLPIVP--EKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDP 104 + R+ W LP++P ++W+L P + ++ +++ L A+ +VHAGD Sbjct: 64 YPEAKRGANGRFP-WLFDHLPLLPANDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDI 122 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREGQLLVDEVL+ L+ R V+R L ++ +V+R + R N +F + +A+A Sbjct: 123 DREGQLLVDEVLEDLRC----RVPVKRVLPKAIDDVSVQRVLADERDNRDFARMRDAAIA 178 Query: 165 RARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 R RADWL G+N +R T+ R AG G +S+GRVQTPVLGL+ R+ EI NF D+ + Sbjct: 179 RGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVL 238 Query: 225 KAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 A I A +F A W+P +P DE GRLL +A V +++G+ + Y D+++ Sbjct: 239 TAMIAVQAG-KFRAKWRPRNG-QPGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQK 296 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 +E+APLPFSL LQ A++R+G+ + L + Q LY++ KL+TYPR+DC YLP A Sbjct: 297 NENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEA 355 Query: 345 HAVMNAI--SVHAPDLLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSSAIN-LTENE 399 ++ A+ D LP + DI ++R +DDK+V AHH I+PT +++ + L+ E Sbjct: 356 AEIVQAVREGFRGTD-LPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSREE 414 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE----- 454 +Y IAR+YL QF P +RK + ++A F+A R + GW+ L G E Sbjct: 415 RLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADD 474 Query: 455 ---RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 ++ D LP + + + CE + ++T+PP FTD TLL AM I ++V Sbjct: 475 DAAPQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQ 534 Query: 512 LK----KILRATD----------GLGTEATRAGIIELLFKRGFL-----TKKGRYIHSTD 552 +K +L+ ++ G+GT ATR L + G + KK ++ T Sbjct: 535 VKAHFVAMLKKSEAGADDQAQGCGIGTPATRHTFAPKLIEIGVVEHIAGKKKAKFFAPTA 594 Query: 553 AGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 AG AL+ +LP T PD TA W+ +I + + FM + ++ + +R Sbjct: 595 AGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINAMLAE-----IR 649 Query: 613 QFRGIVAPGSG-GSADKKKAAPRKRSAKKSPPADEVGSGA 651 Q R IV P G K A ++++A K GSGA Sbjct: 650 QLR-IVLPDLGPRRVPPTKTAGKRKTASKGGKKANGGSGA 688 >UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LWM4_9FIRM Length = 714 Score = 357 bits (916), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 217/622 (34%), Positives = 341/622 (54%), Gaps = 37/622 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNG------QVVTWCIGHLLEQAQPDAYDS 56 ++IAEKP + RA+A L DG +E G G VTW GH+L A P+ Y Sbjct: 7 VYIAEKPDIGRAVAAYLWP-----DGGMEKGKGCFRKGDIAVTWAFGHILGMATPELYGE 61 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 Y W ++ PI+P W ++P P +QL++IK + +A +VHAGDPDREGQLL+DE+L Sbjct: 62 EYKVW--SNYPILPSTWLMKPDPQKKEQLDIIKGLIKDADVVVHAGDPDREGQLLIDEIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 D+L + +V+R LIN + ++++RA LR N +F L + L RARADWL G+N+ Sbjct: 120 DFLHY----KGEVRRILINAKDDESLKRAFASLRDNKDFYGLYEAGLGRARADWLIGMNL 175 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RAYT+ R AG+ G +GRV+ P L LVV+R+++I +F K ++ ++ I F Sbjct: 176 SRAYTVNARKAGHDGTYRIGRVKVPTLALVVQREKDILSFKPKKYYVLQG-IFAYKGVPF 234 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 TA +PSE DEEGR+L L + + ++ ++ + PLP+SL Sbjct: 235 TATLEPSENIP--LDEEGRVLDVNLLQAIKLKVEKAEGVIRDVATSEGKQYPPLPYSLDT 292 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQIEA K +G S Q VL+ QKLYE KL++YPRSDC Y+P ++ A+ Sbjct: 293 LQIEANKIWGYSPQEVLETVQKLYE-RKLVSYPRSDCNYIPASQREDVPRILAALKEM-- 349 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCP 416 D+ + DI ++ ++D K+ AHHAIIPT ++ E E ++Y +I+++Y++QF P Sbjct: 350 DVQGAAGANVDIESKAFNDGKITAHHAIIPTGIRPE-DMNEQEERIYGMISKRYIIQFYP 408 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVVAKGDELLC 475 F K L + F + + + G+R + +EE +GTP LP A GD++ Sbjct: 409 PHEFEKTTFSLQVGDEMFSGSGKIIRKMGFRE---VEREEEEQEGTPRLPDFAVGDKIAK 465 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ-DKDLKKILRATDGLGTEATRAGIIEL 534 ++ ++T+PP+ FT+ TL++AMT I +F++ D ++ ++ G+GT ATR II Sbjct: 466 GDYSILNKKTKPPKRFTEGTLIAAMTNIWKFMKADNPNREKMKEVKGIGTPATRDTIIAE 525 Query: 535 LFKRGF--------LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 L L K + + T G +L ++ PD TA E L +I+ + Sbjct: 526 LQATSLKGKAVEPCLKKVKKELLPTPFGISLIENVSPSLAVPDTTAEMEYALDEIAHGKG 585 Query: 587 RYQDFMQPLVGTLYQLIDQAKR 608 D+M + +++ I A++ Sbjct: 586 NLSDYMDDVYSMVHENIQFAEK 607 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 353 bits (905), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 218/677 (32%), Positives = 361/677 (53%), Gaps = 73/677 (10%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L +AEKPS+AR +++VL KG+G++E + ++TW IGHL+ A+PD YD+ +W Sbjct: 3 QLVLAEKPSVARDLSNVLGN-FNKGNGYLES-DAYIITWAIGHLVTLAEPDDYDAALKKW 60 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 L LPI+P +++L+P + KQ N++K LH + +I+ A D REG+L + Y+ Sbjct: 61 FLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGEL----IFRYI 116 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ +R +++ P AV + D LR ++ L +A AR++ADWL GIN TRA Sbjct: 117 YKLTDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINATRA 176 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ + +LSVGRVQTP L L+V R++EI FV + ++E+ A + + Sbjct: 177 FTV-----KHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYIGK 231 Query: 240 WQPSE--ACEPY---------------------------------------QDE----EG 254 W E A E + QD+ + Sbjct: 232 WFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAMQT 291 Query: 255 RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLD 314 + R A + +++GQP V S K E PL F+L+ LQ EA K+FGLSA L Sbjct: 292 KFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKTLS 351 Query: 315 ICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP-----DLLPQPVVDPDIR 369 + Q+LYE+ KLITYPR+D R + E + A++V A L+ + + Sbjct: 352 VAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKER--KAFLN 409 Query: 370 NRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELD 428 R +D KV H A+IPT ++ L+ +E +VY+L+ R++L F P A + + + + Sbjct: 410 KRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITE 469 Query: 429 IAKGKFVAKARFLAEAGWRTLLGS-KERDEENDGTPLPVVAKGDELLCEKGEVVERQTQP 487 + + F+++ R + GW+T+ +++ +++ LPV+ + +L K ++ E++T P Sbjct: 470 VKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNP 529 Query: 488 PRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY 547 P+ +T+A LLS M G R + D++LK+ +R + GLGT ATRA IIE L K G++ ++ + Sbjct: 530 PKRYTEAALLSVMEGAGRLLNDEELKEAMRGS-GLGTPATRAAIIERLLKVGYIERRKKT 588 Query: 548 IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + T+ G+ L +PE P+MTA WE L I + Q +FM ++ Q+++ A+ Sbjct: 589 LLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELAR 648 Query: 608 RT-----PVRQFRGIVA 619 R P+R R I+ Sbjct: 649 RQKTEGEPLRNNRDIIG 665 >UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 Tax=Campylobacter RepID=A7HZT1_CAMHC Length = 716 Score = 352 bits (903), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 214/643 (33%), Positives = 346/643 (53%), Gaps = 50/643 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP+LA++IA + ++ GDGF + G ++TW GHLLE P+ YD + + Sbjct: 1 MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGE-NIITWAFGHLLELYMPEDYDENFKK 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQL----NVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W+L DLP+ ++++ +P S +QL N+IKR + I++ GD D EGQ+L+DE+L Sbjct: 60 WDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKR--SDVDTIINCGDADEEGQILIDEIL 117 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y ++ V R L++DL + V + ++SN++F L AR+ ADW+ GIN+ Sbjct: 118 KY----ANNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINL 173 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRAYT +N GY+GV+SVGRVQTP+LGLVV RD E E + ++ + T E Sbjct: 174 TRAYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEIL 233 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 + + E DE A + N G+ I+ N+ + E PLP++L Sbjct: 234 ANL----KTDEKITDENE-------ANEIKNICLGKNGILNVTNENK-LEYPPLPYNLLN 281 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ + +K+F L I Q L E +K ITY RSDC YLP + V+N+I + Sbjct: 282 LQADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLS 341 Query: 357 DLLPQPVV---DPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLM 412 D + ++ DP++++R ++D+ + AH AIIPT + N ++++E VY LI+++Y+ Sbjct: 342 DF--ENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIA 399 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVAKGD 471 QF + + IE+ I KF + + + G+ +L G + +++ND V D Sbjct: 400 QFYEPMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDD---EVENSFD 456 Query: 472 ELLCEKG-------EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK--------KIL 516 L E G E+ ++QT+P ++T TLL +T I+++V+D+ +K Sbjct: 457 LSLLESGNCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKK 516 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 G+GT ATR+ I+ LF+R ++ ++ + I ST G+ L P++ + PDMTA W Sbjct: 517 GENGGIGTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYE 576 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGI 617 +I DF+ + + + I+ K + + F GI Sbjct: 577 QQLEIQNGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGI 619 >UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LL88_HALO1 Length = 867 Score = 351 bits (901), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 235/643 (36%), Positives = 352/643 (54%), Gaps = 44/643 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IA V+ K +G++E G G V+WCIGHL E +P YD+++ W+ Sbjct: 6 LIIAEKPSMARDIARVV-GARSKREGYLE-GGGYWVSWCIGHLAELCEPHEYDAKWKSWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P++ +++P S L V+ R + E IV+A D REG+L + ++ Sbjct: 64 PSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGEL----IFRHVH 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ V+R I+ L +A+ R + LR +EF L +A ARA ADWL G+N TRA Sbjct: 120 ALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRAL 179 Query: 181 TILGRNAGYQGVL-SVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP--ADERFT 237 T L R+ G +G+L SVGRVQTP L L+VRR+ EIE+F +K F++V A P A + Sbjct: 180 TGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYE 239 Query: 238 AIWQ-PSEACEPYQD-----------------------EEGRLLHRPLAEHVVNRISGQP 273 IWQ P EA + D + R+ R A+ + + + G+ Sbjct: 240 GIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRA 299 Query: 274 AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDC 333 +T K E PL F L+ LQ A +RF +SA+ L++ Q LYETHKLITYPR+D Sbjct: 300 GTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDA 359 Query: 334 RYLPEEHFAGRHAVMNAISVHAP---DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS 390 RYL ++ ++ A++ P D R +D+ +V HHAIIPTA++ Sbjct: 360 RYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKA 419 Query: 391 -SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL 449 S L+ +E ++Y+LIAR++L PDAV+ + I +A F + R AE GW+ Sbjct: 420 PSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQ- 478 Query: 450 LGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQD 509 + + PLP + + E+ EV E +TQPP+ +++A+LL AM R + D Sbjct: 479 -AEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDD 537 Query: 510 KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRP 568 L++++R GLGT ATRA IIE L KR ++ ++GR + T+ G+AL S+P E Sbjct: 538 PGLRRVMRDA-GLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSA 596 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ-AKRTP 610 ++TA WE L I+ + FM + G + +++D A+ TP Sbjct: 597 ELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATP 639 >UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A8MIQ9_ALKOO Length = 716 Score = 350 bits (899), Expect = 8e-95, Method: Compositional matrix adjust. Identities = 224/663 (33%), Positives = 355/663 (53%), Gaps = 54/663 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RL IAEKPS+A+ IA VL ++ +G+IE G+ ++TW IGHL+ P+ YD RY +W Sbjct: 3 RLVIAEKPSVAKDIAKVLNCKEKR-EGYIE-GSDYIITWAIGHLVILCDPEEYDIRYKKW 60 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 + LPI+P+K +L+P P KQ ++K + + EI+ A D REG+L + Y+ Sbjct: 61 DFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGEL----IFRYI 116 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + R+ QR I+ L + + + L+ + L SA R+ +DWL GIN +RA Sbjct: 117 YELAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRA 176 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 Y+I Y +L +GRVQTP L ++V RD EI++FV KD++EVKA ++ I Sbjct: 177 YSI-----QYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADF-----GNYSGI 226 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W E E D + AE + N++ + +VT + K+ + P + L+ LQ Sbjct: 227 WIDLEKNESKIDSIQK------AEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQR 280 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP--- 356 ++ K+FG +AQ LDI Q LYE K ITYPR+D R+L ++ +++N I + Sbjct: 281 DSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEF 340 Query: 357 ----DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 + L + V+P I N D+KV HHAIIPT + +N +E E +Y+LIAR++L Sbjct: 341 TSILEKLEKLPVNPRIIN----DRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFL 396 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F PD + V+ +A F + + GW+ L KE E + L + KG Sbjct: 397 AVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEV--ETKESTLIHIKKGS 454 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + E+ ++QT+PP + +A LL +M +F++D++LK+ L+++ G+GT ATRA I Sbjct: 455 SSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSS-GIGTPATRASI 513 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 IE + G++ +KG+ + ST+ G+ L + + P++T WE L +I++ Q F Sbjct: 514 IERIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRF 573 Query: 592 MQPLVGTLYQLI--DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP----PAD 645 M+ +G + I D K T + +V G + KK + S+ SP PA Sbjct: 574 MEG-IGRFTKFIIEDVQKNT-----KNVVFEGYSKNRGKKSSGT---SSYNSPIGICPAC 624 Query: 646 EVG 648 +VG Sbjct: 625 KVG 627 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 350 bits (897), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 222/629 (35%), Positives = 348/629 (55%), Gaps = 38/629 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+ + IA VL + K DG++E +V+W GHL+E A P YD + +W+ Sbjct: 4 LVITEKPSVGKDIASVLGRFESK-DGYLE-NEKYIVSWAFGHLVELADPSVYDPVFKKWD 61 Query: 63 LADLPIVPEKWQL-QPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 LA LPI+P+ ++L + S KQL +K+ L+ E S++V+ D REG+ + + + Sbjct: 62 LATLPIIPDSFKLVEIAGSSAKQLRTLKKLLNSAEVSQVVNGCDAGREGESIFRRIYHFC 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R+ ++R +++ P AV+ A LR E+ L +A AR +ADWL G+N TRA Sbjct: 122 GC----RKPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEARGQADWLVGLNGTRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ + VLSVGRVQTP L L+V R+ EI NFV ++EV T + + Sbjct: 178 FTVR-----HGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQTD-NGMYKGK 231 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSALQ 298 W ++++E RL +R A ++ ++S + V S K E F+L+ LQ Sbjct: 232 W--------FREKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNLNDLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG---RHAVMNAISVHA 355 E +R+G +AQ VLDI Q LYE HKL+TYPR+D R+L + R A + +A Sbjct: 284 KEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNAPKYA 343 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQF 414 +L+P + P + R DD K+ HHAIIPTA S L++ E K+Y+L+ R++L F Sbjct: 344 -ELIPDTL--PGLSKRYVDDGKITDHHAIIPTAVDPSKAQLSDQEKKIYDLVVRRFLSIF 400 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GS-KERDEENDG-----TPLPVV 467 P+A + + + A F ++ R AGW+ + GS +E EE +G LP + Sbjct: 401 YPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQALPPL 460 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G + K E++E+QT+PP+ FT+AT+L+AM +FV+DK++ ++L+ T G+GT AT Sbjct: 461 TQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIGTPAT 520 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RA IIE L K G++ + + + T G+ L +P+ ++TA WE L ++ E Q Sbjct: 521 RAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPKQLKSVELTASWEDGLRRVEEGQQN 580 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRG 616 ++Q + +L+ A+ V Q G Sbjct: 581 AALWIQDIQAYTRELVVLARNQEVSQGVG 609 >UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacterales RepID=B9KGJ1_CAMLR Length = 676 Score = 346 bits (887), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 206/622 (33%), Positives = 346/622 (55%), Gaps = 45/622 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L +K +G+I+ G+ ++TW GH+L A P+ Y+ ++ Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNVKKFEGYIQKGDN-LITWAFGHILRLATPEFYNEKWKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 WNL DLP+ ++++ P + KQL +I + + + IVH GD D EGQ+L+DE++ Y Sbjct: 60 WNLNDLPLDIKEFKYIPINNSKKQLEIICKLIKNDQVDSIVHCGDADDEGQILIDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ V R LINDL P+AV+ I +++ NS+F + AR++ADW+ GIN+TR Sbjct: 120 ----SKTKKPVFRVLINDLTPKAVKAEISKMKPNSQFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AYT + + +G++ VL++GRVQTP+LGL+ RD E ENF + D++ + + F Sbjct: 176 AYTSVAQQKSGFREVLTLGRVQTPILGLITARDNEYENFKSMDYYSLLGKFEING-KVFN 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + E +++ +A+ + I+ ++ S +++ E PLP+SL L Sbjct: 235 ARLKTEE----------KIIDENIAKQI-KEININKTVLISVFKEKKKEYPPLPYSLLIL 283 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q E AK +G S L+I Q L E +K ITY RSDC+YLPE F ++N+I ++ + Sbjct: 284 QAECAKLYGYSPDKTLEITQNLREKYKAITYNRSDCQYLPETMFEQAPNILNSIKLNIKN 343 Query: 358 -------LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQ 409 LL + D I+++ ++DK + AH+ IIPT + L E E +Y LI ++ Sbjct: 344 NDSDLSLLLEKS--DLSIKSKAFNDKNISAHYGIIPTQNNFDCGLLKEEEKNIYILIVKR 401 Query: 410 YLMQFCPDAVFRKCVIELDIA-KGKF-VAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 +++QF + +E+ K F ++++ ++E + S E+D E+ L + Sbjct: 402 FVIQFFKPREYEVTNLEIQTYDKSVFGTSQSKNISEGFRKFFKQSDEKDNEDTNNHLDIS 461 Query: 468 AKGDELLCEKG--EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD----- 520 + C+ E+ ++QT+P ++T +LL + +A++V+D+ +KK+L D Sbjct: 462 LIENNSACKIKDIEIEKKQTKPRPYYTMDSLLKDLNSVAKYVKDEKIKKLLIEKDKDKKG 521 Query: 521 ---GLGTEATRAGIIELLFKRGFL---TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHW 574 G+GT ATR+ I+ L ++G++ K + + ST G+ L PE PDMTA W Sbjct: 522 ENGGIGTPATRSTHIKNLIEQGYIEVSKDKKQVVKSTKKGRLLISLAPETLKYPDMTALW 581 Query: 575 ESVLTQISEKQCRYQDFMQPLV 596 I + + +DF+Q ++ Sbjct: 582 FEQQKMIEQGTIKKEDFLQNIL 603 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 345 bits (884), Expect = 5e-93, Method: Compositional matrix adjust. Identities = 223/661 (33%), Positives = 350/661 (52%), Gaps = 72/661 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-RW 61 L IAEKPS+AR +A ++ R+ GF+E G +V+W +GHL+ A+P+ D +A RW Sbjct: 5 LIIAEKPSVARELAPLVGATQRRA-GFLE-GPDHLVSWAVGHLVGIAEPEEQDPAWAGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDYL 119 L LP++P +++L+ P Q V++R L + + +++A D REG+L+ + Sbjct: 63 TLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTGVINATDAGREGELIFRRIY--- 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L E + V+R +D+ + + +++ RL ++E L +++ ARA ADWL G+N +R Sbjct: 120 -LMAECAKPVRRLWASDMTEEGLRKSLARLLPDAEKRNLGLASFARAEADWLVGMNYSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP-------- 231 +T+ G++SVGRVQTPVL L+ R EIE FV +DF+ V+ + TP Sbjct: 179 FTVR-----TGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTVEG-VFTPGGKGRAAQ 232 Query: 232 ------------------------------ADERFTAIWQPSEACEPYQDEEGRLLHRPL 261 A + F A+W P + E R+ Sbjct: 233 GGVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWH-----RPPELRETRVDSEDE 287 Query: 262 AEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE 321 A + N +G+ +V S K S+ PLPF L+ LQ EA RFGLSA++ L Q LYE Sbjct: 288 ASAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKDTLAHAQALYE 347 Query: 322 THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD---LLPQPVVDPDIRNRCWDDKKV 378 THKLITYPR+D R+L +E FA AI PD L + ++ C DD+KV Sbjct: 348 THKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKVKFPCVDDRKV 407 Query: 379 DAHHAIIPTARSS-AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAK 437 HHAIIPTAR L++ E ++Y +I R+++ FC +A F + + + + F+A+ Sbjct: 408 TDHHAIIPTARKGDPARLSQPERQIYEMICRRFIAAFCAEARFATSTVTVKVGEHAFIAR 467 Query: 438 ARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLL 497 + E GW L R E+ TPLP + KG L + V RQT+ P H+TDA+LL Sbjct: 468 GKVFKEKGW--LAVEPWRAAED--TPLPPLRKGARLHTDDIRRVTRQTKAPAHYTDASLL 523 Query: 498 SAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG--- 554 +AM + V+D++L++ ++ GLGT ATRA +IE L +RG++ + G+ + ++D G Sbjct: 524 AAMETAGKLVEDEELRQAMKER-GLGTPATRAQVIETLLQRGYVGRHGKRLIASDRGMQV 582 Query: 555 -KALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ 613 + + LP++A+ P++T WE L + Y FM + +++ + + KR R Sbjct: 583 AEVIEALLPDVAS-PELTGTWEKALKDMEAGTATYPQFMHGIRESVWNGVHRIKRVGGRN 641 Query: 614 F 614 Sbjct: 642 L 642 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 344 bits (882), Expect = 6e-93, Method: Compositional matrix adjust. Identities = 220/624 (35%), Positives = 336/624 (53%), Gaps = 40/624 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-RW 61 L IAEKPS+AR +A VL R GDGF++ G G +VTW +GHL+ A+P + ++ RW Sbjct: 5 LIIAEKPSVARELAGVLGVKGR-GDGFLQ-GPGHIVTWAVGHLVNIAEPAEQNPAWSGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 ++ LP++P ++ L PS KQ +I+ FL + +V+A D REG+L+ + YL Sbjct: 63 SMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRI--YL 120 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 K ++R ND+ + +++A + S E L +A ARA ADWL G+N +R Sbjct: 121 LAGSTK--PIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ AG +++VGRVQTPVL L+V R EIENF+ +D++ V+ E F A Sbjct: 179 FTL---RAG--SLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEG-ETFKAT 232 Query: 240 WQPS---EACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 W + + + +Q EEG + VV +G+ V K+ + PL F L+ Sbjct: 233 WFAAPDFKDSKIWQVEEG--------QTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTN 284 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA R G SAQ L I Q LYE KLITYPR+D RYL +E FA M A+ H P Sbjct: 285 LQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFP 344 Query: 357 DLLPQP---VVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLM 412 ++ + D + C +DKKV HHAIIPT R++ L + E +Y +I R++ Sbjct: 345 EISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAA 404 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F DA F + + + ++ A + + GW L R E++ PLP + KG Sbjct: 405 AFMDDATFASSTLWIGVEGHRYRATGKIFQDKGW--LEAEPWRASEDN--PLPNLRKGAA 460 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + + ++V +T+PP HFTDATLL+AM + + D++L+ ++ GLGT ATRA II Sbjct: 461 VTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKER-GLGTPATRAQII 519 Query: 533 ELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 E L R ++ K G+ + +TD G + +P++A+ P++T WE L ++ + Y Sbjct: 520 ETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVAS-PELTGEWEKRLKEMEQGGYAY 578 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVR 612 FM + + + + K + R Sbjct: 579 GVFMHQVREMVSSGVSRVKGSNAR 602 >UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM3_PAESJ Length = 770 Score = 337 bits (863), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 230/681 (33%), Positives = 348/681 (51%), Gaps = 78/681 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKP + R IA V+ ++E G+ ++TW IGHL+ A+PD YD+RY RWN Sbjct: 4 LIIAEKPDMGRTIAAVVEPKAANKRTYLE-GDRFIITWAIGHLVTLAEPDQYDARYKRWN 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 DLPI+P+K++L P QL I +V+A D REGQL+ + YL+L Sbjct: 63 DQDLPIIPDKFKLWPNARTKDQLKTIGELAKRCGRLVNACDAGREGQLIFHLIRQYLKLP 122 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 Q R I+DL P+ + + D LRS+ ++ PL +A AR+ ADWL G+N +RA+TI Sbjct: 123 ----QPTDRLWISDLTPETIRKGFDSLRSDEDYAPLTRAARARSEADWLIGMNASRAFTI 178 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 ++ +LSVGRVQTPVL L+ R +EI F + ++ VKA + +++ IWQ Sbjct: 179 R-----HKALLSVGRVQTPVLALLYDRHKEITAFKSDMYYVVKA-LFDQNGFQYSGIWQG 232 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF---SLSALQI 299 R+ + AE + + G+P + Y + +ES PF L+ LQ Sbjct: 233 D-----------RITDKAKAEALAAKTQGKPGFIKDY---QTAESKEYPFRLHDLTLLQR 278 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA R+G SA+ LDI Q LYE HK ITYPR++ Y+ EE+ V+ + D Sbjct: 279 EANGRYGYSAKKTLDIAQALYEKHKAITYPRTNSNYVTEENLPVMQKVLTML--QGSDSY 336 Query: 360 PQPVVDPDIRNR-------CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 + D R R + KV+ HHAI+PT + + L+ E +Y++I R++L Sbjct: 337 RELANGAD-RGRVHKGNKAVCNPSKVEDHHAIMPTPKRPS-GLSPEEQNIYDMIVRRFLS 394 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK------------------E 454 Q+ P AV++ + ++ F KA+ L E GW+ +L + E Sbjct: 395 QYYPPAVYKNHTVLTEVESEIFRTKAKELLELGWKVVLQDQGQAAKKTSKKKSSEKDEAE 454 Query: 455 RDEENDGTPLPVVAKGDE-LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 D+E T P + + + C K E +E+ TQPP+ FT+ TLL AM + ++D +L+ Sbjct: 455 SDDEELLTDKPFAIEPQQGVKCVKSESLEKTTQPPKSFTEGTLLKAMESAGKSMEDDELR 514 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPD 569 + ++ T GLGT ATRA IE L + G++ G+ + + G A + ++ P+ Sbjct: 515 EAMKDT-GLGTPATRAATIERLKQVGYVDLTGKKLEISSKGCAAIELIRGAGVDLLASPE 573 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPG------SG 623 MT WE L QIS + F+ + ++D+ VRQ R APG SG Sbjct: 574 MTGRWEQRLHQISRGEASDDQFIMKVKQFAAMIVDK-----VRQQR-PAAPGTFEERESG 627 Query: 624 GSADKKKAAPRKRSAKKSPPA 644 G K+ AA KR ++ S P+ Sbjct: 628 G---KRGAAGTKRGSRTSKPS 645 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 337 bits (863), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 225/622 (36%), Positives = 335/622 (53%), Gaps = 40/622 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECG------NGQVVTWCIGHLLEQAQPDAY 54 MRL IAEKPS A+ +A P RK + IE G +V W +GHL E +P Y Sbjct: 1 MRLIIAEKPSQAQKLAAPYPSKKRKEE--IEISPCPRFPEGAIVVWAVGHLCELQEPSHY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLV 112 + W LPIVPE++ + +K IK++LH+ S +++ A D +REG+ +V Sbjct: 59 RPEWKSWKYEALPIVPERFDYRISKGKSKPFYAIKKWLHDRSITDVIIASDAEREGEAIV 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L +LA K+ + R I+ L QAV+R +L + +P A++RA ADWL Sbjct: 119 RLIL---RLAGNKKP-LARLWISSLTEQAVDRGFSQLLPGEQTIPYYHEAMSRACADWLV 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N +RAYT L + G + V S+GRVQTP L L+V R+ EI+ FV + +FEV+A + Sbjct: 175 GMNASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEPYFEVEATLAK-G 233 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 F A + + +L R A+ VV R SG AIV + + + + E P F Sbjct: 234 RGTFKAKYTFGKTT--------KLKTREEADAVVKRASGT-AIVKTIDKEEKIEQPPFWF 284 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL-PEEH--FAGRHAVMN 349 SLS LQ EA KRFG A+ LDI QKLY T I+YPR+D ++ P+E F A + Sbjct: 285 SLSGLQAEAGKRFGFGAKKTLDIAQKLY-TKGWISYPRTDSGFVTPDEATLFPQTKARLL 343 Query: 350 AISVHAP--DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLI 406 +A DLL + DP R + KKV H+AIIPT A L +EAK+Y+LI Sbjct: 344 KSDAYAGLRDLLTE---DPSKNRRYVNAKKVSDHYAIIPTEACGDVTRLGGDEAKLYDLI 400 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 R++L F P A+ K ++L + AK + G+R ++ K +D E LP Sbjct: 401 NRRFLAAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVE-----LPA 455 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + G+E +K EV+ +QT+PP+ +T+ L+ AM + + D++L I++ +GLGTEA Sbjct: 456 LTVGEEFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLGTEA 515 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQ 585 TRA II+ L KRG++ + + + TD G+ L L + + P MTA WE L +I + Sbjct: 516 TRANIIDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSILASPVMTAKWEKRLHEIGQAS 575 Query: 586 CRYQDFMQPLVGTLYQLIDQAK 607 +F++ L+++AK Sbjct: 576 ASAAEFIEQAKKMSVHLVEEAK 597 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 336 bits (862), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 201/620 (32%), Positives = 333/620 (53%), Gaps = 37/620 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + IAEKPS+AR IA VL K +KG+G++E G+ +VTW +GHL+ A P++YD +Y +WN Sbjct: 5 VVIAEKPSVARDIARVL-KCDKKGNGYLE-GSKYIVTWALGHLVTLADPESYDVKYKKWN 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP++PE+ +L KQ N +K L + +EI+ A D REG+L+ ++D ++ Sbjct: 63 LEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVR 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + ++R I+ + +A++ L+ + L SA+AR+ ADW G+N TRA Sbjct: 123 I----NKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRAL 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T + L+ GRVQTP + ++ R++EI+NF A+ ++ ++A + W Sbjct: 179 T-----TRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTN----QLKLTW 229 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + R ++ + +V + A V + K++ +P + L+ LQ + Sbjct: 230 QDANG-------NSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRD 282 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K+FG SA+ L+I QKLYE HK++TYPR+D RY+ + + A V L Sbjct: 283 ANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLA 342 Query: 361 QPVVDPDIR-NRCW-DDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 V+ I+ N+ + DD KV HHAIIPT + T+ E K+Y+L+ +++L P Sbjct: 343 HKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPA 402 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP------LPVVAKGD 471 + + + + F+A+ + + AGW+ + + R E++D T LP + KGD Sbjct: 403 FEYEQLTLRTKVGNETFIARGKTILHAGWKEVY--ENRFEDDDVTDDVKEQLLPRIEKGD 460 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV--QDKDLKKILRATDGLGTEATRA 529 L + QT+ P F +ATLLSAM +++ Q+K L L++T GLGT ATRA Sbjct: 461 TLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRA 520 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 II+ LF + K+G+ IH T G+ L +PE P +T WE L I++ + + + Sbjct: 521 DIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKE 580 Query: 590 DFMQPLVGTLYQLIDQAKRT 609 F+ + +++ + K + Sbjct: 581 VFISEMKNYTKEIVSEIKSS 600 >UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damselae subsp. damselae CIP 102761 RepID=D0Z5F5_LISDA Length = 727 Score = 332 bits (852), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 211/635 (33%), Positives = 329/635 (51%), Gaps = 38/635 (5%) Query: 1 MRLFIAEKPSLARAIADVL---PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 MRLFIAEKPSLA+AI + L PK RK G+ E GN +VTWC+GHLLEQ+ P+ Sbjct: 1 MRLFIAEKPSLAKAIFEGLGGNPKTQRK-QGYFENGN-DIVTWCVGHLLEQSPPEH---- 54 Query: 58 YARWNLADLPIVPEKW-QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 +W L LPI E +++P Q V++ + +A IV+A DPD EG LL DE+L Sbjct: 55 --QWKLEYLPIKSEYPPKMRPIEKTKDQFKVVQDLIKKADSIVNASDPDEEGNLLCDEIL 112 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y + V+R L+ DLN + V+RA+ ++ N F SALAR+ D ++G NM Sbjct: 113 TYCH----NTKPVERLLVADLNLEPVKRALANMQPNENFHGWTQSALARSIGDLIFGFNM 168 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 ++AYT+ R GY G +GRVQT LG++ R ++ F++V A ++ Sbjct: 169 SQAYTLKAREMGYSGTFGIGRVQTVALGMINERTLANQSHQESYFYQVYADFAF-NNQTV 227 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A + P+ E DE+ RLL + A+ + Q A++ K P P+ LS+ Sbjct: 228 KARYLPTTNNE--VDEQNRLLSKTEAKQIAQATDNQHALIIDAQTKPTKSLPPRPYDLSS 285 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ AK++G SA+ LDICQ LYE HK++TYPR+D R+L + H R A+ I+ P Sbjct: 286 LQQLCAKKWGYSAKKTLDICQSLYEKHKVLTYPRTDNRFLGDSHLEQRVAIFKNIAEAIP 345 Query: 357 DLLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLIARQYLMQF 414 +L D +++ +D K+ AHHAI+PT S+ + LT++E +Y +AR ++ F Sbjct: 346 ELSSMVANADLSLKHHAFDASKITAHHAIVPTLTSAKGLTLTKDEQTIYEFVARSFIALF 405 Query: 415 CPDAVFRKCVIELDIA-KGKFVAKARFLAEAGWRTLLGSK-ERDEENDGTPLPVVAKGDE 472 P +V + + +++A K +F A L+ GW L E ++ +G L + + E Sbjct: 406 YPASVRDRTEVTIELANKYRFKANQTQLSVVGWEVLYKDDIEAEKPIEGVDLTTLKRDQE 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGT 524 + + +T+PP++ +A+L++ M + ++D +L+ A D +GT Sbjct: 466 TKASNPTIEKGKTKPPKYHDEASLIAFMKKAGKLIKDPELRAKFEAKDKGDRDNCGSIGT 525 Query: 525 EATRAGIIELLFKRGFLTK-------KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 EATRA I++ + R L + K + +T G+ LP T PD++A W Sbjct: 526 EATRANILDTVKSRSDLVQVVKMKGYKQKVWITTPLGQEFCAMLPSEFTAPDISAIWSQH 585 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 I + F+ L G + +D+ K V Sbjct: 586 QLAIKNGDMTVEQFLDELDGFVAHYVDKVKTNGVN 620 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 332 bits (851), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 206/600 (34%), Positives = 325/600 (54%), Gaps = 33/600 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+AR IA +L KG G++E GN +VTW +GHL+ A+P+ YD +Y W Sbjct: 4 LVLAEKPSVAREIARIL-NCTIKGKGYLE-GNKYIVTWALGHLVTLAEPEDYDEKYKTWR 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 DLP++P + + Q +++ + + + E++ A D REG+L+ ++ + Sbjct: 62 TEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQAR 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ +R I+ L +A+ RLR +E+ L SA+ RA ADWL G+N+TRA Sbjct: 122 C----QKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVTRAL 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ Y LS GRVQTP L ++V R++EI+ FV DF+ VKA++ +F A W Sbjct: 178 TV-----KYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANL-----GKFQAEW 227 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + R AE +VN++ + V + +SE PL + L+ LQ + Sbjct: 228 RDKSG------KHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRD 281 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K+FG +AQ L Q LYE HKL+TYPR+D RYL + + A+S L Sbjct: 282 ANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFAELV 341 Query: 361 QPVVDP--DIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPD 417 +P+ I R D+ KV HHAIIPT R++ LT E +Y+LI R+++ F P Sbjct: 342 KPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVFYPA 401 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG--SKERDEENDGTP---LPVVAKGDE 472 +++ + + IA F A + + GW+ + S+E+D D TP LP + KGD+ Sbjct: 402 YSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKKGDK 461 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + + V+ QT+PP +T+A+LLSAM +F++D+ LK+ ++ + GLGT ATRA II Sbjct: 462 VKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKES-GLGTPATRAEII 520 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E + ++ ++G+ + T G L +P + D+TA WE L I+ + + F+ Sbjct: 521 EKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRTKFI 580 >UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shewanella putrefaciens 200 RepID=A2UW18_SHEPU Length = 708 Score = 329 bits (844), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 222/683 (32%), Positives = 332/683 (48%), Gaps = 39/683 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECG-----NGQVVTWCIGHLLEQAQPDAYD 55 M L IAEKP++A+AIA L K R +G+I+CG Q+V+WCIGHLL P+ ++ Sbjct: 1 MHLIIAEKPAVAKAIAGYLNKNARSCNGYIDCGADGKGQKQIVSWCIGHLLTFKTPEEHN 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 Y W + LP+ L+P QL + L A+ + HAGD D EGQ+LVDEV Sbjct: 61 PLYKTWAVETLPMQLLPLTLKPIAKTKAQLKTLLDLLKSANLVTHAGDDDDEGQILVDEV 120 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 LDY + + QV R INDLN ++ +A ++ NS+F+ SA R+ D++YG+N Sbjct: 121 LDYAKY----KGQVNRLKINDLNEASIAKAFSNVKPNSQFLSQSQSAYGRSAFDFIYGLN 176 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI-VTPADE 234 +TR T+L N GV SVGRVQ+ +L LVV R + + ++++ A + Sbjct: 177 LTRLCTVLSGNG---GVFSVGRVQSAILSLVVERCRLNRSHTSIPYYDIFAAVRFREGAI 233 Query: 235 RFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +F CEP + D++ RLL RP AE + + G+ +T + S PLPFS Sbjct: 234 KFKVDLNEIAECEPEKFDDKKRLLDRPQAEFIKLSLEGRSVNITDLDRTNSEASPPLPFS 293 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE-HFAGRHAVMNAIS 352 L LQ + F S + L + Q L E HKLITY R+D YLPEE H G H + N I Sbjct: 294 LLDLQKACSNLFDYSPEQTLKLTQSLREDHKLITYNRTDTGYLPEEFHPQGAH-IANCIK 352 Query: 353 VH-APDLLPQPVVDPDIRNRCWDDKKV--DAHHAIIPT-ARSSAINLTENEAKVYNLIAR 408 ++ + D I++R + D KV AHH IIP R+ +T++E VY LI R Sbjct: 353 LNCSAFAAAVDAADFSIKSRAFSDAKVAESAHHGIIPCDVRADMGKVTKDEMNVYMLICR 412 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVV 467 +L QF P + + + K A + GW L G D+E + Sbjct: 413 NFLAQFFPKKITAHIKVTASAGEYKLTAMGSQIERNGWSALYSGESFEDDEEQAELTQEL 472 Query: 468 AKGDEL----LCEKGEVV-------ERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 DEL + G + E +++P + + LL + A +V +++LK++L Sbjct: 473 TAFDELDGLGKYDSGHIYSGDTSLREGKSKPKALYVMSRLLEDLKKAATYVTNENLKRVL 532 Query: 517 RATD-------GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPD 569 D G+GT ATR IIELLF R F+ KG+ I +T G+ + LP D Sbjct: 533 IERDKGTQEKGGIGTPATRGSIIELLFNRQFIEMKGKKIIATPFGEQAYDQLPSYLASVD 592 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKK 629 +TA W+ + Q+ +++ F+ + G + Q ++ K + + + G A K Sbjct: 593 LTAFWQLKMNQVRDRELSIGRFLTEVDGFVTQAVNHIKSQGISITSQPTSKTNKGKAGAK 652 Query: 630 KAAPRKRSAKKSPPADEVGSGAI 652 P+ S + G I Sbjct: 653 SGKPKMASTATEFQCKQCGEKLI 675 >UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C314B9 Length = 754 Score = 325 bits (834), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 210/626 (33%), Positives = 330/626 (52%), Gaps = 58/626 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+ R ++ VL P R+G+GF+E G ++TW +GHL++ A+PD YD ++ RW Sbjct: 5 LVIAEKPSVGRDLSRVLAGPFRRGEGFLE-GPDHILTWAVGHLVQLAEPDEYDDKFKRWR 63 Query: 63 LADLPIVPEKWQLQPRPSVTK-QLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 +ADLPIVPEK++L R +K Q+NV+KR L + +V+A D REG+L + YL Sbjct: 64 MADLPIVPEKFRLVVRDERSKRQMNVVKRQLGRDDIGVVVNACDAGREGEL----IFAYL 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR ++ + A+ A +LR +E L +A +R+ ADW+ G+N TRA Sbjct: 120 YEKAGSRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDAARSRSEADWIVGMNSTRA 179 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA----DER 235 TI R++ + G +S+GRVQTP L ++ RR+EEI F + ++ V A D R Sbjct: 180 ATIRLRSS-FDGAVSLGRVQTPTLAILARREEEIRAFRPEPYWTVDATFAASGERVYDGR 238 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 F + P R+ A VV G ++T ++ E PL + L+ Sbjct: 239 FHVTAGSGDGRGP------RIGSAEFAAAVVEACRGTDGVITKLEKRKRRERVPLLYDLT 292 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE----------EHFAGR- 344 +LQ +A RFG SA+ L Q+LYE HK +TYPR+ RYLP E GR Sbjct: 293 SLQRDANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEIKPIAEIVGGRS 352 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVY 403 A V D+LP R +D +V HHAIIPT ++ + +++ ++Y Sbjct: 353 EYAAGARYVLGLDVLPLA--------RVVNDARVTDHHAIIPTRAPHPVDRMGDDDRRIY 404 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +L+A+++L F PDA F +E ++A F + + + GWR + G E D P Sbjct: 405 DLVAKRFLAVFHPDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYG-----ESADAEP 459 Query: 464 ------------LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 LP + +G+++ + +++T+PPR +++ +LL+AM + V +++ Sbjct: 460 REGEEDEGREQQLPKLEQGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEEE 519 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDM 570 L++ ++ + G+GT ATRA IIE L G++ + GR + T+ G + L T P + Sbjct: 520 LREAMKDS-GIGTPATRAAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGHPLTSPSL 578 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLV 596 T WE L +I + + FM +V Sbjct: 579 TGDWEHRLGKIELNEDSRRAFMADIV 604 >UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepID=B2RH95_PORG3 Length = 710 Score = 325 bits (834), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 212/641 (33%), Positives = 332/641 (51%), Gaps = 35/641 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+ R IA VL + G++E GNG VTW GHL +P Y + R Sbjct: 36 MIVCIAEKPSVGREIAAVL-GATKAYKGYME-GNGYQVTWTFGHLCALKEPHDYAPEWKR 93 Query: 61 WNLADLPIVPEKW--QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+++ LP++P ++ +L S+ +Q I++ +HEA +V+ GD +EG+L+ VL Sbjct: 94 WSISSLPMIPLRFGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDAGQEGELIQRWVLQK 153 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 V+R I+ L +++ RLR + EF L + LARA DWL G+N TR Sbjct: 154 TGCTC----PVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAIGDWLLGMNATR 209 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ R + VLS+GRVQTP L L+VRR EIE+F + ++EVK D F A Sbjct: 210 LYTL--RFGSNRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVKT---IYRDTVFNA 264 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +GR A V ++G P VTS K+ E P F L+ LQ Sbjct: 265 T-------------KGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLTGLQ 311 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +E KRF ++A L Q LYE K+ +YPR D YL ++ F ++ +S + Sbjct: 312 VECNKRFAMTADATLRTIQSLYE-KKITSYPRVDTTYLSDDVFEKVPNILQGLSDYTLLT 370 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 P + +D+ K+ HHAIIPT + S ++E+E +V++L+AR+++ F PD Sbjct: 371 APLRSSKLKKSKKVFDNSKITDHHAIIPTGQPSH-GMSEDERRVFDLVARRFIAVFYPDC 429 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG----TPLPVVAKGDELL 474 +F + + AK +F + + E GWRT+ + D++ + LP+ ++G+ + Sbjct: 430 IFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFSEGESGV 489 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 EV E+ TQPP+ +T+ATLL AM + V+D++L+ L+ +G+G +TRA IIE Sbjct: 490 -HTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKE-NGIGRPSTRAAIIET 547 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LFKR ++ K+ + + +T G +L ++ E+ ++T WE L +I DF+ Sbjct: 548 LFKRNYIYKEKKNLKATPTGMSLIATIDYELLKSAELTGQWEYKLRRIERGDYSAADFIN 607 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 L L LI ++ P + + KKK A + Sbjct: 608 ELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADK 648 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 325 bits (832), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 209/619 (33%), Positives = 325/619 (52%), Gaps = 28/619 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A IA L K D + E + V++ +GHLLE A P+ Y+ + +W+ Sbjct: 27 LIIAEKPSVANDIARALGG-FTKHDEYFESDDF-VLSSAVGHLLEIAAPEEYEVKRGKWS 84 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 A+LP++P + L P +L V+ + + + +++A D REG+L+ + + + Sbjct: 85 FANLPVIPPHFDLNPIAKSESRLKVLNKLIKRKDVDRLINACDAGREGELIFRLIAQHAK 144 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 +Q VQR + + P A+ +LR+++E PL +A R+ ADWL GIN TRA Sbjct: 145 ----AKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARCRSEADWLVGINGTRAM 200 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T G + +VGRVQTP L +VV R+E+I FV +D++EVKA V + + Sbjct: 201 TAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCASGFYEGRWY 260 Query: 241 QPSEACEPYQDE--EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P + + E + RL P AE +V GQ VT K ++ +P F L++LQ Sbjct: 261 DPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTE-ESKPSTQLSPALFDLTSLQ 319 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM------NAIS 352 EA RFG SA+N L + Q LYE HK++TYPR+D R LPE++ M N Sbjct: 320 REANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLETVKHTMEMLKESNNYL 379 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 HA +L + V P+ R +D+ K+ H AIIPT ++ L+E E K+Y+L+ +++L Sbjct: 380 PHAKQVLDKGWVKPN--KRIFDNSKISDHFAIIPTLQAPKA-LSEPEQKLYDLVVKRFLA 436 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P A +R ++ F + + L E GW + G + E+ + P V K ++ Sbjct: 437 VFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRETGGEDANLVP---VQKDEK 493 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + T+PP + +ATLLSAM G + V+D +L++ + A GLGT ATRA II Sbjct: 494 VKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAM-AAKGLGTPATRAAII 552 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM----ATRPDMTAHWESVLTQISEKQCRY 588 E L +L ++GR + T L L + T P++T WE L+Q+ + Sbjct: 553 EGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGEWEYKLSQMERGKLPR 612 Query: 589 QDFMQPLVGTLYQLIDQAK 607 FMQ + ++ +AK Sbjct: 613 DAFMQEIARMTQTIVKRAK 631 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 325 bits (832), Expect = 5e-87, Method: Compositional matrix adjust. Identities = 217/654 (33%), Positives = 330/654 (50%), Gaps = 69/654 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+AR IA VL H+ G IE G+ +VTW +GHL+ A P+ YD ++ W+ Sbjct: 4 LVLAEKPSVARDIARVLG-CHKNISGAIE-GSNYIVTWALGHLVTLADPEEYDKKFKAWD 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKR--FLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 ++ LP+VP+KW+L +KQ + +K F + SEI+ A D REG+L+ +LD Sbjct: 62 MSYLPMVPKKWELVVIKQTSKQYHNVKTQLFRKDVSEIIIATDAGREGELVARWILD--- 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++R I+ + +A++ L+ + L +A +RA ADWL GIN TRA Sbjct: 119 -KSGCHKPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARSRAEADWLVGINATRAL 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFF------EVKAHIVTPADE 234 T Y LS GRVQTP L ++ R+++I +F +D++ V V Sbjct: 178 T-----CKYNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTSVTGGSVGTMAS 232 Query: 235 RFTAIWQPSEACEPYQDEEGRL--LHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 T WQ Q + G L ++ L + ++ Q VT + + +P + Sbjct: 233 IVTWTWQ--------QKKSGSLRSFNKDLITGLDKKLKNQTLTVTDVHTSSKRTPSPGLY 284 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 L+ LQ +A KRFG SA+ L+I Q LYE HK++TYPR+D RY+ + + A + Sbjct: 285 DLTELQRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKERLKACN 344 Query: 353 V-----HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLI 406 + + P+LL +P+ DDKKV HHAIIPT + +++ NE K+Y+L+ Sbjct: 345 IGPYKKYIPELLKKPL---KTSKAFVDDKKVSDHHAIIPTEEYVQMEHMSNNERKIYDLV 401 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL---------------- 450 R+++ P + + ++ + A F AK + + AGW+ + Sbjct: 402 VRRFISVLYPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSASQYDAY 461 Query: 451 GSKERDEE-------ND------GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLL 497 G E E+ ND LPV+ KGD L + + +T+ P FT+ATLL Sbjct: 462 GDYEDSEDFGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARFTEATLL 521 Query: 498 SAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGK 555 SAM R++ D +KK L T GLGT ATRA IIE LF L KKG I T GK Sbjct: 522 SAMENPVRYMSSDDNKMKKTLGETGGLGTVATRADIIEKLFHSFLLEKKGNEILLTSKGK 581 Query: 556 ALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT 609 L +PE +P++TA WE L +I++ + Q F++ + +LI K + Sbjct: 582 QLLELVPEDLKKPELTASWEMELAKIAKGAHKEQVFIKDIESYTKELIQDIKTS 635 >UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=A8U720_9LACT Length = 713 Score = 324 bits (831), Expect = 6e-87, Method: Compositional matrix adjust. Identities = 198/605 (32%), Positives = 332/605 (54%), Gaps = 32/605 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECG-NGQVVTWCIGHLLEQAQPDAYDSRYAR 60 R+ +AEKPS A+A A+ K +K DG+I + ++TW GHL+E A P+ Y + + Sbjct: 3 RVILAEKPSQAQAYAESFGKFSKK-DGYIILNPSNDIITWGFGHLVELASPEEYRDEWKK 61 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ +LPI+P+ ++ + +KQ N+IKR L EA +IV A D DREG+ + ++ Sbjct: 62 WNMKELPIIPQTFKFKVGQGKSKQFNIIKRLLKEADQIVIATDSDREGENIARSIISQ-- 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 A ++++R IN L +++ LR +F + A R +DWL GIN++R Y Sbjct: 120 -AKADNKEIKRLWINSLEADEIQKGFSDLRDGKDFYSAYIEAQTRQISDWLVGINLSRMY 178 Query: 181 TI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ L + +GV SVGRVQTP L ++ R +EIENF+ + FFE+ A I F A Sbjct: 179 TLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKEIENFIPEPFFEMHATIKAEKGS-FKAK 237 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + P + E L + +H + ++ P +++ KR S+ +P FSLS LQ Sbjct: 238 YNKK---FPTKKE----LQDLIKKHEL--LASNPGVISDIGTKRISQPSPFLFSLSDLQS 288 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 K++ +S + L Q LYE KL++YPRSDCR++ + F H ++ I + +L Sbjct: 289 LINKKYKVSPSDTLKHVQSLYEA-KLLSYPRSDCRHITDSEF---HYLIERIDGYQ-SVL 343 Query: 360 PQPVVDPDI--RNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAKVYNLIARQYLMQ 413 + P+ R R D KV H+AIIPT + LT + ++Y + ++ + Sbjct: 344 NYTIEQPNTSKRKRYVDGSKVQEHYAIIPTKKVPTQKELDKLTSIQKEIYYTVLKRTMAM 403 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL--LGSKERDEENDGTPLPVVAKGD 471 F D + + I ++I K F++K R + + GWR L SK+ D+E + T LP+V K + Sbjct: 404 FETDYKYDETTITVEIKKLPFISKGRTILDKGWRKLEYAASKKTDKE-ENTELPLVQKNE 462 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + E T PP+ +T+ TL++AM + +++ + K+IL+AT+G+GTEATRA + Sbjct: 463 AIEADLA-TSEGFTAPPKSYTEGTLITAMKTCGKELENVEEKEILKATEGIGTEATRANV 521 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQCRYQD 590 +E L K+ ++ + + T G L ++ + + P+MTA WE+ L +I +++ + Sbjct: 522 LETLKKQHYIEIQKNDVTVTQKGAILCQAVKNTLLSSPEMTAKWETYLKKIKKEEGTQEA 581 Query: 591 FMQPL 595 F++ + Sbjct: 582 FLENI 586 >UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62_9FIRM Length = 709 Score = 322 bits (826), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 211/618 (34%), Positives = 320/618 (51%), Gaps = 55/618 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L +AEKPS+A +++ V+ R GDG++E GNG +V+WC+GHL+E +QP+AYD +YA+ Sbjct: 18 MKLVLAEKPSVAMSLSKVIGADQR-GDGYME-GNGYLVSWCVGHLVELSQPEAYDEKYAK 75 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+PE WQ Q S KQ ++K+ + + ++ A D REG+L+ L Y Sbjct: 76 WKYDDLPILPEHWQYQVSASTKKQFGILKKLMQRKDVESLICATDAGREGELIFR--LVY 133 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 Q +K V+R I+ + A+ +LR +E+ L +AL R RADW+ GIN TR Sbjct: 134 HQCGCKK--PVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATR 191 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++ L Y L+VGRV TP L +VV RD I F + F+ A+ +F Sbjct: 192 LFSCL-----YGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYS--------AELKF-- 236 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESAPLPFSLSAL 297 +Q R+ + AE +V AI+T K +SE P F L++L Sbjct: 237 --------RDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSL 288 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH--- 354 Q EA ++ G +AQ LD Q LYE KL+TYPR+D RYL ++ +++ I Sbjct: 289 QREANRQLGFTAQQTLDYTQALYE-KKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQI 347 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT---ENEAKVYNLIARQYL 411 PD P PV + N KKV HHAIIPT ++ +++ E + ++ + + Sbjct: 348 QPD-APAPVNTAQVIN----TKKVTDHHAIIPTKTAAGYDISSLPSGEQAILTMLTVRLI 402 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP--LPVVAK 469 + + ++E + A KF K + + + GWR G D E + LP++++ Sbjct: 403 CAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGKAVEDAEKNAEAGELPILSE 462 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G L ++ E +T PP+ FT+ LLSAM + D+ + R G+GT ATRA Sbjct: 463 GMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESAS---SDEFPAGVER--KGIGTPATRA 517 Query: 530 GIIELLFKRGFLTKKG----RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ 585 IIE L ++GF+ ++G +Y+ STD G AL +PE P MTA WE L +I + Sbjct: 518 AIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGE 577 Query: 586 CRYQDFMQPLVGTLYQLI 603 FM + + L+ Sbjct: 578 YDSDAFMGEISSMVSGLV 595 >UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID=B1HX02_LYSSC Length = 725 Score = 319 bits (817), Expect = 3e-85, Method: Compositional matrix adjust. Identities = 203/621 (32%), Positives = 320/621 (51%), Gaps = 31/621 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECG------NGQVVTWCIGHLLEQAQPDAY 54 M++ IA KP A +A P G+ E NG ++TW GHL E P+ Y Sbjct: 1 MKIVIAAKPDQAAKLAA--PWSFTIKTGYFEVKANSYFPNGAIITWATGHLCELKTPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLV 112 DS + +W L LPI+P++++ + S KQ +IK + A EI+ GD REG+L++ Sbjct: 59 DSTWKKWKLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQEIIIGGDAGREGELII 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L + + ++R I+ L +V+ L ++ + AL+R+ ADWL Sbjct: 119 RTILRVCGV----NKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIYYEALSRSCADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 GIN +R YT+L + G + V S+GRVQTP L L+V R+ EI NF ++ F+EV+A + A Sbjct: 175 GINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSEPFWEVEA-VFHFA 233 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + A W +++ R+L A + N + +T + + + PL F Sbjct: 234 GKMLKAKW--------HKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKEYAPPLLF 285 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS LQ A K + S Q LDI QKLY L++YPRSD ++L E ++N +S Sbjct: 286 NLSGLQATANKAYKFSPQKTLDILQKLY-VKGLVSYPRSDSQFLTSEEAKTLPTILNNLS 344 Query: 353 V--HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQ 409 +LLP P+ R ++KKV HHAII T + ++ L+ E K+Y+L+ARQ Sbjct: 345 KMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTEQMPNLSKLSMEEEKIYDLVARQ 404 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLG-SKERDEENDGTPLPVV 467 + A+F I + K +F++K + E GWR ++ +K+ + + LP++ Sbjct: 405 VIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQEEEEMLPLL 464 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + + + V + TQPP +++ L++ M + + D +L+K+L T+GLGTEAT Sbjct: 465 HENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSKTEGLGTEAT 524 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQ 585 RAGII L R ++ K + +T G L +L E + T P MTA WE L +I E Sbjct: 525 RAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGENSLLTSPSMTAKWEQRLAEIGEGH 584 Query: 586 CRYQDFMQPLVGTLYQLIDQA 606 Q FM+ + Y+LI A Sbjct: 585 ASPQAFMEQVKKLTYKLITDA 605 >UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family n=6 Tax=Bacteria RepID=Q1DEW9_MYXXD Length = 1560 Score = 318 bits (815), Expect = 4e-85, Method: Compositional matrix adjust. Identities = 218/657 (33%), Positives = 337/657 (51%), Gaps = 51/657 (7%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKPS+AR IA VL + +G+G++ GNG VVTW IGHL+ AQP + + +W+ Sbjct: 1 MLAEKPSVARDIARVL-GANERGEGWLR-GNGYVVTWAIGHLVGLAQPHEIRADWKKWSR 58 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQL 121 A LP++P W L Q V+K+ L+ E S +V A D REG+L + Y+ Sbjct: 59 ALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGEL----IFRYIYD 114 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 A + R+ VQR ++ L +A++ RL E+ L +A+ R+RADWL G+N++R YT Sbjct: 115 AAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYT 174 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV-----TPADERF 236 + + G+ +LSVGRVQTP L +VV R+ I +FV +D+ E+ A P D + Sbjct: 175 LA--HGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALY 232 Query: 237 TAIW---QPSEACEPYQDEEGRLLHRPL------AEHVVNRISGQPAIVTSYNDKRESES 287 W P EG R L A+ +++R+ AI+ S + + + Sbjct: 233 KGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMA 292 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL + L+ LQ A + G SAQ L++ Q LYE HKL++YPR+ R+L V Sbjct: 293 PPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEV 352 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLI 406 +NAI + L + R DD KV HHAIIPT + + L+ +E +VY+L+ Sbjct: 353 VNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLV 412 Query: 407 ARQYLMQFCPDAVFR-KCVIELDIAKG------KFVAKARFLAEAGWRTL-LGS------ 452 R+ L + D V+R VI + G +F + + + GW+ L +G Sbjct: 413 CRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPR 472 Query: 453 ----------KERDEENDGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMT 501 ER+ E++ LP +A+ E E V+++T+PP FTDATLL+AM Sbjct: 473 LKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAME 532 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 R + +K+L +R T GLGT ATRA IIE+L R +L ++G+ + +T+ G L + Sbjct: 533 SAGRALDEKELADAMRET-GLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVV 591 Query: 562 PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 P MT WE+ L +I + + +F++ + + +++ P R R V Sbjct: 592 HPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEV 648 >UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychrophila RepID=Q6AJY0_DESPS Length = 820 Score = 318 bits (814), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 197/617 (31%), Positives = 317/617 (51%), Gaps = 18/617 (2%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A +A VLP K E + +V++ +GHL+ P+ D Y +W Sbjct: 6 LIIAEKPSVAGDLAKVLPGKFTKQKTHYES-DSHIVSYAVGHLVSLCYPEEIDPIYQKWG 64 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 LA+LPI+PE + L+ + QLN +K+ + + +EI++A D REG+L+ +L Y+ Sbjct: 65 LANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYVW 124 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ ++R + + +++++ + LR N L +AL R+ +DWL G+N TRA Sbjct: 125 NTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRAL 184 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T G + GRVQTP L L+V+R+ F D+ ++A+ ++ W Sbjct: 185 TGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFETGS-YSGKW 243 Query: 241 -QPSEACEPYQD--EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 P+ +P + R+ + A ++ + +PA T N K +SAP F L+AL Sbjct: 244 IDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATE-NSKESRQSAPQLFDLTAL 302 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF-AGRHAVMNAISVHAP 356 Q EA RFG SA+N L I Q LYE HK +TYPR+D R+LPE++ + N Sbjct: 303 QREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEFA 362 Query: 357 DLLPQPVVDPDIR--NRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 + + + I+ R +++KK+ HHAIIPT + NL+E E K+Y ++ +++L F Sbjct: 363 AIAKTALKEGYIKAQTRIFNNKKISDHHAIIPT-NTLPQNLSEPELKIYTMVVQRFLAIF 421 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P AVF + F+ + + L EAGW+ + + D P + G + Sbjct: 422 FPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYAGADGSTGKDKILAP-IPTGSPVT 480 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 C K E T PP + +ATLLSAM +F+++++L ++ GLGT ATRA IIE Sbjct: 481 CNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKER-GLGTPATRATIIEK 539 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMA----TRPDMTAHWESVLTQISEKQCRYQD 590 L K ++ ++ + + T LF + M P+MT WE L QI + + D Sbjct: 540 LIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRDD 599 Query: 591 FMQPLVGTLYQLIDQAK 607 FMQ + Q++D+ + Sbjct: 600 FMQEIRQLTQQIVDRVR 616 >UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales RepID=C3QFV7_9BACE Length = 725 Score = 318 bits (814), Expect = 6e-85, Method: Compositional matrix adjust. Identities = 212/631 (33%), Positives = 338/631 (53%), Gaps = 50/631 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IA+VL H + +G+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIAEVL-GAHTRKEGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKWQLQ---PRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W+L+ LP++P ++ ++ P + KQ +VI+ + A EI++ GD +EG+L+ V+ Sbjct: 59 WSLSSLPMIPPRFGIKLIGHDPGIEKQFHVIEWLMQNADEIINCGDAGQEGELIQRWVMQ 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 R V+R I+ L +A+ +L+ +EF L + L+RA DWL G+N T Sbjct: 119 ----KAGARCPVKRLWISSLTEEAIREGFSKLKDQAEFQSLYEAGLSRAMGDWLLGMNAT 174 Query: 178 RAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 R YT+ G+N + VLS+GRVQTP L L+V R EI NF K ++E+K + + F Sbjct: 175 RLYTLKYGQN---KQVLSIGRVQTPTLALIVNRQLEIANFEPKQYWELKTNY---RNTTF 228 Query: 237 TAIWQPSEACEPYQDEEGR------------LLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 +A+ + S+ ++E+ + +R E +V RI P +VT+ K Sbjct: 229 SALIRKSDEEIAAEEEKNGGKKKIDNPGIDPIANREEGEALVERIKDLPFVVTNVGKKDG 288 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 E AP F L++LQ+E K+F SA L + Q LYE K+ TYPR D +L ++ + Sbjct: 289 KEYAPRLFDLTSLQVECNKKFAYSADETLKLIQSLYE-KKVATYPRVDTTFLSDDIYPKC 347 Query: 345 HAVMNAISVHAPDLLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 A++ + + ++L P+ + + +D+ KV HHAIIPT A NLT+ E +V Sbjct: 348 PAILKGLRDY--EVLTAPLAGTTLLKSKKVFDNSKVTDHHAIIPTG-VYAQNLTDMERRV 404 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-----E 457 Y+LIAR+++ F PD + ++ K +F + + E GWR + + +D E Sbjct: 405 YDLIARRFIAVFYPDCKISTTTVMGEVDKIEFRVTGKQILEPGWRVVFAKEVKDPTEEKE 464 Query: 458 ENDGTPLPVVAKGDELLCEKG----EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 E D LP KG E G ++ E+ TQPPR +T+ATLL AM + V + +L+ Sbjct: 465 EEDENVLPAFVKG-----ESGPHIPDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDELR 519 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTA 572 L+ +G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ ++T Sbjct: 520 DALKE-NGIGRPSTRAAIIETLFKRNYIRKERKNLIATPTGVELVQLIHEELLKSAELTG 578 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 WE L +I +K + F++ L + +++ Sbjct: 579 IWEKKLREIEKKTYDARQFLEELKQMVSEIV 609 >UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_OENOB Length = 722 Score = 317 bits (812), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 201/628 (32%), Positives = 336/628 (53%), Gaps = 29/628 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIEC-----GNGQVVTWCIGHLLEQAQPDAYDSR 57 + +AEKPS AR+ + L K K +G+ N +T+ GHL+E A P+ YD + Sbjct: 4 VILAEKPSQARSYVEAL-KNSTKKEGYFSVSDPVLANETFITYGFGHLVELATPEKYDQK 62 Query: 58 YARWNLADLPIVPEKWQ-LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 Y RW+L++LPI P+K++ + PR T Q ++K L +A I+ A D DREG+ + ++ Sbjct: 63 YKRWSLSNLPIFPDKYKFIVPRDKKT-QFKIVKDLLMKADTIIIATDSDREGENIAWSIM 121 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + ++ K + ++R IN L A+ L+ + P A R +DWL G+N Sbjct: 122 NQAKINL-KSKTIKRLWINSLEKDAILNGFKNLKDAWNYYPAYQEAQTRQISDWLVGMNG 180 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 + YT+L R +G +GV S+GRVQTP L +V +RD+EI+NF + +FE+ A I ++F Sbjct: 181 SPLYTLLLRQSGVRGVYSIGRVQTPTLYMVYQRDQEIKNFKPEPYFEISAEI-EANRQKF 239 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A P + ++DEE ++ E R Q A+ + + ++P FSLS+ Sbjct: 240 VAKLDPYQR---FKDEESLTIY---MEAKGLRTGFQEALTKDVLQETKRTASPRLFSLSS 293 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA-VMNAISVHA 355 LQ KR+ SA +VL Q LYE KL+TYPR+DC Y+ ++ F+ + +M +S+ + Sbjct: 294 LQSAINKRYHASASDVLKAVQALYEA-KLLTYPRTDCNYITDQEFSYLLSNLMGYLSLVS 352 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA----RSSAINLTENEAKVYNLIARQYL 411 + + + + R + KKV HHAII T ++ L + + +VY L+ R L Sbjct: 353 SQV---SLNNTEANKRYVNSKKVQEHHAIIMTKTIPNKAKLAALPKLQQQVYGLVLRTTL 409 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F + + +I ++ K F A + GW+ L + + LP V K Sbjct: 410 AMFADPYEYEQTIIITEVGKANFKATGNVPIKQGWKLLFADDKDKNDETVVTLPKVTKNQ 469 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 ++ + + +++T PP FT+ TL++AM R + D++ + IL+ +G+GTEATRA + Sbjct: 470 KVQADL-KTPQKETTPPVPFTEGTLITAMKTAGRTLDDEEAQSILKDVEGIGTEATRANV 528 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHS--LPEMATRPDMTAHWESVLTQISEKQCRYQ 589 +E+L KRG+L K +H ++ G L + L + T P+MTA WE L +IS+K+ + Sbjct: 529 LEVLKKRGYLLSKKNQLHVSEQGITLCTAVELEPLLTSPEMTAKWELALKEISQKKRSQE 588 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGI 617 F+ + + +L+D+ T ++Q G+ Sbjct: 589 SFLIQIKKFVSKLVDEVP-TQMKQSEGL 615 >UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q21RE9_RHOFD Length = 1017 Score = 314 bits (805), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 207/644 (32%), Positives = 330/644 (51%), Gaps = 46/644 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIEC--GNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 L IAEKPS+A+ I L K D E + VVT +GHLLE P+ +D + + Sbjct: 19 LIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKRGK 78 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W+ A LP++P + L+P +LN + + + ++++A D REG+L+ + Y Sbjct: 79 WSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRLIEQY 138 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 A + V+R + + PQA+ + LRSN + +PL +A R+ ADWL GIN TR Sbjct: 139 AGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGINGTR 198 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER--- 235 A T G + +VGRVQTP L +VV R+E+I FV++D++EV A A + Sbjct: 199 AMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGDYPAK 258 Query: 236 -FTAIWQPS---------EACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 F W+ + E +P + + RL + A+ + + + GQ A VT K + Sbjct: 259 WFDPQWKKAAANAAAGNLEEADP-ELKADRLWQQREAQAIADAVRGQTASVTE-ESKPTT 316 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF---- 341 +++PL F L++LQ EA +FG SA+ L I Q LYE HK +TYPR+D R LPE++ Sbjct: 317 QASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVK 376 Query: 342 ----AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE 397 + M ++ HA L + P R +D+ KV H AIIPT ++ + L+E Sbjct: 377 QTFEMLSKSAMRHLAPHALTALNNNYIRPS--KRIFDNSKVSDHFAIIPTLQAPS-GLSE 433 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG-KFVAKARFLAEAGWRTLLGSKERD 456 E K+Y+L+ R+++ F P+A + + + +A G F + + L + GW + G + D Sbjct: 434 AEQKIYDLVVRRFMAVFFPNAEY-QITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVD 492 Query: 457 EEND---------GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 E D G L V G+ + + E +T+PP +T+ATLL AM G + + Sbjct: 493 EVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTI 552 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM--- 564 +D +L+ + GLGT ATRA IIE L + ++ ++GR + T + L L + Sbjct: 553 EDDELRAAMH-EKGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVK 611 Query: 565 -ATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 ++ ++T WE L + Q +FM + +++ QAK Sbjct: 612 ELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAK 655 >UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bacteroides RepID=B7AD12_9BACE Length = 729 Score = 313 bits (801), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 221/688 (32%), Positives = 345/688 (50%), Gaps = 70/688 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IADVL K DG+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIADVL-GARDKRDGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKW--QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L LP+VP ++ +L P+ +Q +VI+ + A I++ GD +EG+L+ V+ Sbjct: 59 WSLGSLPMVPPRFGIKLISNPTYERQFHVIENLMQHADMIINCGDAGQEGELIQRWVMQ- 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 R V+R I+ L +A+ +LR S+F PL + L+RA DWL G+N TR Sbjct: 118 ---KAGARCPVKRLWISSLTEEAIREGFAKLRDASDFQPLYEAGLSRAIGDWLLGMNATR 174 Query: 179 AYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 YT+ G+N + VLS+GRVQTP L L+V R EI+NFV K ++E+K D F+ Sbjct: 175 LYTMKYGQN---RQVLSIGRVQTPTLALIVNRQLEIQNFVPKQYWELK---TVYRDTTFS 228 Query: 238 AIWQPSE---ACEPYQDEEGR---------------LLHRPLAEHVVNRISGQPAIVTSY 279 AI + S+ E + +EG + R ++ +I P +T+ Sbjct: 229 AILRKSDEELVLEAEKQKEGAAAKAAKPEENRGIEPITDRERGTALLEQIRNAPFTITNV 288 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K E+ F L++LQ+E K+F SA L Q LYE K+ TYPR D +L ++ Sbjct: 289 TRKNGKEAPLRLFDLTSLQVECNKKFAFSADETLKTIQSLYE-KKVTTYPRVDTTFLSDD 347 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENE 399 + ++ + + P + +D+ KV HHAIIPT + NLT+ E Sbjct: 348 IYPKCPGILKGLRDYQALTAPLEGTTLLKSKKVFDNSKVTDHHAIIPTGQPPQ-NLTDME 406 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 +V++LIAR+++ F PD +F + ++ + +F + + E GWR + G+ + Sbjct: 407 RRVFDLIARRFIAVFYPDCLFATTTVIGEVEQIEFKVSGKQILEPGWRVVFGTPSAQSQE 466 Query: 460 DGTP--------LPVVAKGDELLCEKG----EVVERQTQPPRHFTDATLLSAMTGIARFV 507 + LP G E G ++ E+ TQPPR +T+ATLL AM + V Sbjct: 467 EKDEKGGEEENVLPAFVVG-----ESGPHLPDLYEKWTQPPRPYTEATLLRAMETAGKLV 521 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMAT 566 + +L+ L+ +G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ Sbjct: 522 DNDELRDALKE-NGIGRPSTRAAIIETLFKRNYIRKEKKNLIATPTGVELIQIIHEELLK 580 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI-----DQAKRTPVRQFRGIVAPG 621 ++T WE L +I ++ F++ L + +++ D + R Q AP Sbjct: 581 SAELTGIWEKKLREIEKRTYNAGQFLEELKQMVSEIVMSVLSDNSNRHITIQ---APAPE 637 Query: 622 SGGS--------ADKKKAAPRKRSAKKS 641 GG +DK K P+KR+ +KS Sbjct: 638 KGGKNSASSASASDKPKKEPKKRAPRKS 665 >UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0_9FIRM Length = 703 Score = 313 bits (801), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 215/627 (34%), Positives = 322/627 (51%), Gaps = 68/627 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS++RAIA+V+ R+ DG+++ G +V+WC GHL E PDAYD ++ + Sbjct: 1 MYLVIAEKPSVSRAIAEVIGAQERE-DGYLQ-GTDCMVSWCFGHLAEYVSPDAYDEKFNQ 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W++ Q ++KR L+ E +V+A D REG+L+ V D Sbjct: 59 WRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYD- 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ K+ V+R I+ L A+ + LRS E+ L +A+ R++ADWL G+N TR Sbjct: 118 --LSGSKK-PVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI-----VTPAD 233 AYT Y L+VGRVQTP L ++V R +I NF + +F V+ V P Sbjct: 175 AYT-----TKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGIPAVKP-- 227 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 I+ P E AE + +R G AIVT+ + + AP + Sbjct: 228 ----KIFDPDE-----------------AEQLRSRCQGSEAIVTAVKETEKKVKAPKLYD 266 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-- 351 L+ LQ EA + +G++A+ LD Q LYE KLITYPR+D +YL E+ V+ I Sbjct: 267 LTTLQREANRIYGMTAKQTLDTAQSLYE-KKLITYPRTDSQYLTEDMEQTARNVVRQIYE 325 Query: 352 --SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTEN---EAKVYNLI 406 + P P+ PD++ + ++ KV HHAIIPT ++ +L E E K+ LI Sbjct: 326 KYQLTGPFDQPE---QPDVK-KVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLI 381 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL---LGSKER------DE 457 A +M D ++++ IE++ + F AK + + + GW+ +K+R D+ Sbjct: 382 AVHTVMAMSKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQ 441 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E +P V +G E E T PP+ +++ TLL+AM D+D +K Sbjct: 442 EM-KERMPKVTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEK--- 497 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 GLGT ATRAGIIE L + T+KG+ I TD GK L LP+ MTA WE+ Sbjct: 498 --KGLGTPATRAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQ 555 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLID 604 L + + + FM + L +++ Sbjct: 556 LLLMEHGEIAPEQFMTGIKNMLTMMLN 582 >UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tasmaniensis RepID=B2VAT6_ERWT9 Length = 722 Score = 312 bits (800), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 201/632 (31%), Positives = 325/632 (51%), Gaps = 42/632 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA+ +K G+ EC VVTWC GH+L P A + Y Sbjct: 1 MILTIAEKPELAEIIANAFGNAVKK-QGYYECAGNNVVTWCFGHMLVLTPPAAVNPSYEV 59 Query: 61 WNLADLPI----VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W + DLP+ V + + V +Q +I L ++S ++HAGDPD EG+LLV E+L Sbjct: 60 WKMDDLPMDLTAVSHQVKATENGYVERQYKIICDLLKKSSSVIHAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR--SNSEFVPLCVSALARARADWLYGI 174 +L+ + V+R L+NDLN A ++AID++ ++ +F+ L + ALARA+ D ++G+ Sbjct: 120 -WLE---NYTKPVKRLLLNDLNINAAKKAIDKMEDGNSDKFIRLALKALARAKGDQIFGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 NMTR +T+L + G +G L+ GRVQTP+LGL+V R + + V +++V + D Sbjct: 176 NMTRYFTLLSQRLGGRGKLTCGRVQTPMLGLIVARYKAFNSHVKSYYYDVSSTHNFLKDF 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 I A +G+++ +A+ + G+P+ V S + ++ +APLPF L Sbjct: 236 PLKIIPNDDFAV------DGKIIDPDVAQKIKEACEGKPSSVASVKVEDKATAAPLPFDL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 LQ K +S L++ Q L + I+Y RSDCRYL + +NA+ + Sbjct: 290 LGLQSYMLKD-KISPDETLELTQSLRSNYSAISYNRSDCRYLSSDQHEEAPDTLNALKKY 348 Query: 355 A-----PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIAR 408 D++ D + + ++DK + +H AIIPT + ++ E KVY I Sbjct: 349 VGDGALNDVINNTSFDISRKGKAFNDKNITSHTAIIPTPNPRGLEKMSAKERKVYEAIVL 408 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN-----DGTP 463 +YL+QF D ++ + +D A ++ A A L AGW + + + + DE N D P Sbjct: 409 RYLLQFVDDKKYKSAKVVVDCAGYQYSASATRLISAGWSS-IEADDSDESNNNDGEDSQP 467 Query: 464 L----PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 L ++ G++ C + + +T+P +T T L + ++++V D +KK+L + Sbjct: 468 LFESISALSNGEQSSCTGVIISKAETKPLPLYTMKTFLEDLKRVSKYVSDPRIKKLLLSK 527 Query: 520 D--------GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMT 571 D G+GT ATR+ II+ L G+ T + + T+ G SLP T PDMT Sbjct: 528 DEGKKGERGGIGTPATRSTIIKNLENTGYYTIQSNKLIPTEKGIKFIESLPVSVTAPDMT 587 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 A W T I + + DF+ + T+ +L+ Sbjct: 588 ALWHEQQTMILDGEMELSDFIININQTVAELM 619 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 312 bits (799), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 211/619 (34%), Positives = 320/619 (51%), Gaps = 63/619 (10%) Query: 3 LFIAEKPSLARAIADVLP-----KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 L +AEKPS+AR IA VL KP+ +G +I VTW +GHL+E P+ YD + Sbjct: 4 LVLAEKPSVARDIARVLGCKETHKPYFEGPRYI-------VTWALGHLVELKMPEDYDRK 56 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 Y W L DLPI+P+K L+ + Q I+R + +++ A D REG+L+ + Sbjct: 57 YETWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWI 116 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L+ + + + R I+ +A+ +L+ ++F L SA+ RA ADWL G+N Sbjct: 117 LEMIGWT----KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLN 172 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 ++RA T Y LS GRVQTP L +++ R+ EI++FV ++ ++A I + Sbjct: 173 VSRALT-----TKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGS----- 222 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 TA+W+ + RL + A+ ++ R+ GQPA V S KR+SE APLP+ L+ Sbjct: 223 ITAVWE--------RHGGHRLFDQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDLT 274 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQ +A KRFG SA+ L + Q+LYE HKL+TYPR+D RYLP + A + A+ Sbjct: 275 ELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGY 334 Query: 356 PDLLPQPVV---DPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYL 411 D++ P++ R ++D KV HHAI+PT R + L+ +E K+Y+LIAR++L Sbjct: 335 EDVIA-PLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFL 393 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVVAKG 470 F P DI FVAK + G++ +LG EE D P L +A+G Sbjct: 394 ALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLGK----EETDAKPTLSHLAEG 449 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 L + E + T+PP +++A LL+ M GLGT ATRA Sbjct: 450 QTLPSVQLEREQSFTEPPARYSEADLLAQMEKY-----------------GLGTPATRAD 492 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 IIE L + + +K + T GK L + E P++TA WE L I+ + Q Sbjct: 493 IIERLVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQ 552 Query: 591 FMQPLVGTLYQLIDQAKRT 609 F+ + QL+ + K++ Sbjct: 553 FLANIRRQTQQLVAEIKQS 571 >UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organisms RepID=A5FHK0_FLAJ1 Length = 768 Score = 312 bits (799), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 192/593 (32%), Positives = 322/593 (54%), Gaps = 47/593 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA VL + K DG+ E GNG VT+ GHL +P+ Y + Sbjct: 1 MKVCIAEKPSVAREIASVLG-ANTKHDGYYE-GNGYAVTYTFGHLCTLKEPNDYKPHWKS 58 Query: 61 WNLADLPIVPEKWQLQ--PRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L +LP++PEK++ + + KQ +IK +A +++ GD +EG+L+ V++ Sbjct: 59 WDLNNLPMLPEKFETKVVQNSGIQKQFKIIKTLFDKAELVINCGDAGQEGELIQRWVMN- 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + +++R I+ L +A++ D L+ + + L + +RA DWL G+N TR Sbjct: 118 ---EAHYKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAIGDWLLGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ ++ GY+ VLS+GRVQTP L +VV R +EIENF + ++E++ Sbjct: 175 LYTV--KHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQ------------T 220 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +++ + + EEGR L + E + ++ + S + K +E AP F L+ LQ Sbjct: 221 LYRET----LFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLTGLQ 276 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++FG SA+ L I Q LYE K ITYPR D +LP + + ++ ++ ++ Sbjct: 277 VYCNQKFGFSAEETLKIAQTLYE-QKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSH-- 333 Query: 359 LPQPVVDPDIRN--RCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCP 416 L +P++ I+ + ++DKKV HHAIIPT INL N+ +VY++I +++L F Sbjct: 334 LTEPLLGKKIKKSPKVFNDKKVTDHHAIIPTGIE--INLPYNQQQVYDIIVKRFLAVFYD 391 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-KERDEENDGTPLPVVAKGDELLC 475 D + + A F A + + + G+R + +++E D P VV Sbjct: 392 DCLVANTTVIGKAADVTFKATGKEILKKGFRVVFEDPNAKEKEPDLLPSFVVG------- 444 Query: 476 EKG----EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 EKG ++++T+PP HFT+ATLL AM + V D+DL+++++ +G+G +TRA I Sbjct: 445 EKGPHEPSFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKE-NGIGRPSTRANI 503 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISE 583 IE LFKR ++ + + + T G L ++ E+ ++T WE L I + Sbjct: 504 IETLFKRQYIVRNKKQVLPTTTGIQLIDTIQNELIKSAELTGSWEKQLKDIEK 556 >UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocellum RepID=C7HGZ2_CLOTM Length = 652 Score = 311 bits (797), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 211/638 (33%), Positives = 339/638 (53%), Gaps = 38/638 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGD---GFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 +L+I EKPS+A + A+VL K D G+ E + VVTWC GHL+ A PDAYD +Y Sbjct: 4 KLYITEKPSVAASFAEVLGMKITKQDRSKGYAESEHS-VVTWCFGHLITMAYPDAYDPKY 62 Query: 59 ARWNLADLPIVPE--KWQLQPRPSVTKQLNVIKRFLH-EASEIVHA-GDPDREGQLLVDE 114 W + DLPI+P+ K+ + + KQ IK ++ E +++ A D REG+ + Sbjct: 63 REWKVEDLPIIPKVYKYIVIDDEGIKKQFETIKTLMNREDIDLIFACTDSGREGEYIFR- 121 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L Y Q K+ +R I+ +A+ I + E+ L +A +RA+ DWL+G+ Sbjct: 122 -LVYEQSGSNKK--AKRVWISSQTEEAIREGILNAKDIEEYDSLARAAYSRAKEDWLFGM 178 Query: 175 NMTRAYTIL-GR------NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAH 227 N +R YT L GR V+++GRV T VLGLVV R++EI NF+ K + + A Sbjct: 179 NFSRIYTCLYGRKLSNFLKESKTSVIAIGRVMTCVLGLVVDREQEIRNFMPKKHYGITAT 238 Query: 228 IVTP-ADERFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 ++ ++ + W P + + D+E + + R AE V+ R+ G P + K + Sbjct: 239 FLSSVSNLLYKGKWVPQNKKDDKEADDEEKYISREEAEQVIERLKGHPGKIKKVEVKTKK 298 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 E PL F+L+ LQ EA K+F L L+I Q LYE KLITYPR+D R + + Sbjct: 299 EQPPLLFNLAELQSEANKKFKLPVDKTLEIAQWLYE-KKLITYPRTDSRVISTDVLEEVP 357 Query: 346 AVMNAISVHAP--DLLPQPVVDPDIR-----NRCWDDKKVDAHHAIIPT-ARSSAINLTE 397 V+N I + D + + D++ R D+ KV H+AIIPT + + + E Sbjct: 358 KVLNGIYKNPEYRDYVLKIKEMGDLKVTKSTKRYVDNSKVTDHYAIIPTYVNAETVRMDE 417 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL--LGSKER 455 N VYNLI +++L F P AV+ +E + FV+ A+ L EAGW+ + + + ++ Sbjct: 418 NTKNVYNLIVKRFLAIFFPPAVYNTVRVETVVNNEIFVSNAKTLKEAGWKEVYEVSAPKQ 477 Query: 456 DEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 DEE P+ ++ K + + + E+ E++T+PP +TD +L+ M +F++D++L++ Sbjct: 478 DEELTEAPIHLLVKNEAVEAKDFELEEKETKPPSRYTDGSLIITMEKAGKFIEDEELREQ 537 Query: 516 LRATDGLGTEATRAGIIELLFKRGF--LTKKGRYIHSTDAGKALFHSLPEMATR---PDM 570 ++ T G+GT ATRAGII+ L G+ + K + + T G+A+ + A P + Sbjct: 538 IK-TCGIGTSATRAGIIKKLSDIGYIKINPKTQVVTPTLKGEAIVELVRRTARELLSPSL 596 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 TA WE L I K+ + F + L + + I++ KR Sbjct: 597 TASWEKGLAMIENKETTAEIFEEKLCVYINKTINKVKR 634 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 311 bits (796), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 200/630 (31%), Positives = 322/630 (51%), Gaps = 52/630 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFI------ECGNGQVVTWCIGHLLEQAQPDAY 54 M + +AEKP AR +A P PH KG+GF+ E NG VTW IGHL+E +P+ Y Sbjct: 1 MIVILAEKPDQARKLAS--PFPHTKGNGFLSIQSCKEFPNGATVTWAIGHLVELKEPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+LA LPI+P +++ + KQ +K+ L EA EI+ A DP REG+ + Sbjct: 59 RPEWKKWDLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEIIIATDPAREGENIARL 118 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 ++ +A +++++R + L A+ + L+ E + L A AR ADWL G+ Sbjct: 119 LI---LMAGCSKKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHEAQARQIADWLVGM 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA-- 232 N +R YT+L + G + V SVGRVQTPVL L+ R +EIE F + F+E++ Sbjct: 176 NASRLYTLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPFYELEGQFTVKNGT 235 Query: 233 -----DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 ++RF++ P E L+ ++ + A++ S + Sbjct: 236 YRGKLNKRFSS---PDE------------LYEAVSPDITKEQQTYQAVIKSVRISEKRTP 280 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA--GRH 345 AP SLS LQ + + S VL++ Q LYE ++YPR+D +Y+ EE + +H Sbjct: 281 APKLHSLSTLQSKLNRTKKFSPTKVLELVQSLYE-KGYVSYPRTDSQYITEEEYTYLQKH 339 Query: 346 A--VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINLTENE 399 + +H P QP R + +KV H+AIIPT + + + +E Sbjct: 340 VDQYQQCLGIHVPIRSLQP------SKRYVNPEKVSDHYAIIPTEKVPDTKAFETFSSDE 393 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 +VY I + L F D V+ + VI + K +FV K R E GW+ L + E+DEE+ Sbjct: 394 KEVYYEILKSALAMFMTDYVYDETVIITSVGKQEFVTKGRTEKEMGWKALYQN-EKDEES 452 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQ--TQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 +G + ++ + E K ++ +Q TQPP+ +T L++ M ++V+D+++K+ L Sbjct: 453 EGEQVAILPEVKEGESAKADISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALN 512 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWES 576 +GLGTEATRA II+ L +R + K + T G+ L ++ + ++P+MTA WE Sbjct: 513 QVEGLGTEATRAAIIDTLIQRRLIEVKKNQVFVTKKGEILCEAVKGTILSKPEMTAKWEL 572 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 L +I + + F++ Y LI QA Sbjct: 573 FLQEIGKGNRSKEVFIEQAKKLCYALIQQA 602 >UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp. enterica serovar Agona str. SL483 RepID=B5EWF7_SALA4 Length = 726 Score = 311 bits (796), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 207/639 (32%), Positives = 323/639 (50%), Gaps = 55/639 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA +K G+ EC N VVTWC GH+L PD + Y Sbjct: 1 MILTIAEKPELAEIIAKAFGGEVKKS-GYWECANNNVVTWCYGHMLVLTPPDKVNPSYKT 59 Query: 61 WNLADLPI----VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W ++DLP+ V + + V +Q +I L ++S +++AGDPD EG+LLV E+L Sbjct: 60 WVMSDLPMDLTEVSHEVKTTENGYVERQYKIITDLLRKSSSVINAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR-SNSE-FVPLCVSALARARADWLYGI 174 + VQR L+NDLN A ++A+ +L+ NSE F+ L + ALARA+ D +YG+ Sbjct: 120 ----WKENYNKPVQRLLLNDLNVNAAKKALSKLQDGNSEKFMRLALKALARAKGDQIYGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV--------KA 226 NMTR YT+L R G G L+ GRVQTP+LGL+V+R E+ +N V ++++V Sbjct: 176 NMTRYYTLLNRQHGGNGKLTCGRVQTPMLGLIVKRYEDFKNHVKSNYYDVYSSHNILKSV 235 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 ++ AD++F +G++L +AE++ + +P+ V + + Sbjct: 236 YLKLIADDKFAT--------------DGKILSPEVAENIKSACVMKPSTVVVAKVEDKHT 281 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETH-KLITYPRSDCRYLPEEHFAGRH 345 PLPF L LQ K + ++I QKL I+Y RSDCRYL + + Sbjct: 282 PPPLPFDLLGLQAYMLKD-NIDPTETMEITQKLRSKEIAAISYNRSDCRYLTSDQYDEAP 340 Query: 346 AVMNAISVHAPDLLPQPVVDP---DIRNR--CWDDKKVDAHHAIIPTARSSAIN-LTENE 399 A + A+ + + + V++ DI+ + ++D V AH IIP+A ++ LT E Sbjct: 341 ATLEALKKYISGGILESVINNNGFDIKRKGIAFNDDNVSAHTGIIPSAEPRNLDKLTSKE 400 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD--- 456 KVY I +YL+QF D ++ + ++ +F A L GW L D Sbjct: 401 KKVYEAIVLRYLLQFLDDKKYQSAKVIIECEGYRFGGSATKLVSPGWTALEAEDSDDDSA 460 Query: 457 EENDGTPLPVVA--KGDEL-LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 EEN + ++ K D++ +C V +++T+P +T T L + ++R+V D +K Sbjct: 461 EENTDSAFDAISAMKVDDVGVCNDVRVDKKETKPLPVYTMKTFLEDLKRVSRYVTDPHIK 520 Query: 514 KILRATD--------GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA 565 ++L + D G+GT ATRA II L G+ T + + T+ G +LP Sbjct: 521 QLLLSKDKGKKGERGGIGTPATRATIISNLESTGYFTVQNGKLIPTEKGIGFIKNLPVAV 580 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLID 604 + PDMTA W I E DF+ + T+ +L++ Sbjct: 581 SAPDMTALWHEQQMMIMEGDLELGDFIININNTVKELMN 619 >UniRef50_A5TXI0 DNA topoisomerase TopA n=2 Tax=Fusobacterium RepID=A5TXI0_FUSNP Length = 713 Score = 310 bits (794), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 199/637 (31%), Positives = 322/637 (50%), Gaps = 50/637 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEK LA AI +P + I G+ + W GH+L +P+ D + Sbjct: 1 MKLIIAEKKELAEAIVAAIPGDKKYKGNSITVGD-YITCWIYGHILVHKEPEEIDPSLKK 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W L LPI KW +P P+ + N +K +H + +EI+HAGD D EGQ LVDEVL+Y Sbjct: 60 WTLESLPIYFPKWDKKPLPNKIELFNSVKELMHSNQVTEIIHAGDGDSEGQYLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R ++ND V++A ++ NS ++PL SA ARA AD + G +++R Sbjct: 120 CS----NKKPVKRLIVNDNTLGGVKKAFSKIDDNSNYIPLGKSAEARAIADMIVGFSLSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 Y+I+ LSVGRVQTP + LVV RD EI+N + + ++ + T Sbjct: 176 YYSIIN-----NAKLSVGRVQTPTMTLVVNRDNEIKNHIKEKYYNLYLK---------TN 221 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSLSA 296 I + Y E ++ + + E ++N+I + + +V+ + RE+ PLP++LS Sbjct: 222 INNIDIDLKYYTKE--KITDKSIHEELINKIGDKISNLVVSKKENYRET---PLPYNLSD 276 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 L+ +AA F + Q V+DI Q L + HK ITY RS+ YL EEHF + I V A Sbjct: 277 LESDAATLFKYTTQKVMDITQSLRDKHKAITYNRSNSSYLTEEHFKEAPKI---IPVVAQ 333 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCP 416 + +N+C++DK HH IIPT + + +E E +Y LIA +Y +QF Sbjct: 334 KFNFTATFNFSQKNKCFNDKYSVPHHGIIPTGAGNFESFSEEEKNIYKLIAERYFIQFLE 393 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG-----------SKERDEENDGTPLP 465 K + +I + F + + E G+ E EN+ + +P Sbjct: 394 KIKVEKTEAKAEIEEIIFKKGSTKILEPGYTKYFKILDDEDNENEEEIESKIENNLSEIP 453 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD----- 520 E+ + E++T + +T+ATL+ + IA++V+D +++++L++ D Sbjct: 454 AGEYQIEVSQANFFIEEKETVAKKPYTEATLIKDLNNIAKYVKDSEIRELLKSKDKDRKD 513 Query: 521 ---GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 +GT AT GI+E L ++GFLT+K I ST+ K LPE PD TA W S+ Sbjct: 514 VNGSIGTVATIPGILEGLIEKGFLTRKEEKIVSTELAKEYLKILPESLKTPDSTALWWSI 573 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF 614 +I+ + + +D ++ + +I+ +T +F Sbjct: 574 QEKIARGEAKIEDLTLSVLEDVKIIINSEHKTISSEF 610 >UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group RepID=A9VVE2_BACWK Length = 714 Score = 308 bits (789), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 201/627 (32%), Positives = 327/627 (52%), Gaps = 48/627 (7%) Query: 3 LFIAEKPSLARAIADVLPK-PHRKGDGFIE-CG---NGQVVTWCIGHLLEQAQPDAYDSR 57 L +AEKP+ A+A A+ PK R+G ++ C +G +TW GHL+E P Y Sbjct: 4 LVLAEKPNQAKAYAEAFPKVEKREGHFYVPPCSLLPSGGNITWAYGHLVELKSPQDYKKE 63 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W+L+ LPI+P +++ + KQ N++K+ + EA V D DREG+ + ++ Sbjct: 64 WEKWDLSQLPILPSRYEYKVSADKKKQFNIVKKLMKEADTTVVDVDIDREGEAIARLII- 122 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Q A ++++R IN L +++ L+ +F + A AR +DW+ G+N + Sbjct: 123 --QEAGCTHKKIKRLWINSLEVDEIKKGFQNLKPGEDFESMFEEAQARQLSDWIVGMNAS 180 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA----- 232 R YT+L R G QGV SVGR QTP L L+ +R +EI+NF FFE++A +P Sbjct: 181 RLYTLLLRQKGVQGVYSVGRCQTPALCLINKRQQEIKNFKPTPFFELEAQFTSPNGVYMG 240 Query: 233 --DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 ERFT +G L++ L +H ++ S Q +V S K + + A Sbjct: 241 RYKERFTT--------------KGELMNL-LQQHSISENSSQQGMVKSVEVKPKQQEATK 285 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG-RHAVMN 349 FSLS++Q A K++ S +VL Q+LYE KL+TYPR+DC Y+ E F ++ + Sbjct: 286 LFSLSSIQALANKKYKYSPADVLKGIQELYEA-KLVTYPRTDCNYITEGEFEYLKNNLSG 344 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT----ARSSAINLTENEAKVYNL 405 S+ + + P + R D+KKV H+AI+ T +R + L + + +Y Sbjct: 345 YQSIASVNFQPHSLT---ANKRYVDNKKVQEHYAIVLTKNVPSRETIARLPDKQRNLYME 401 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG---T 462 + + L F ++ + VI D+ F K + GW+ L + + +EE+D + Sbjct: 402 VLKSVLSMFYAPYMYEETVITSDLNGLLFTTKGKAEKSLGWKELYVTDKIEEEDDQEKVS 461 Query: 463 PLPVVAKGDELLCEKGEVVERQ--TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LPVV +G+ + +G V ++ T PP+ +T+ L++ M V+D++ K IL+ + Sbjct: 462 LLPVVKQGEFV---QGLVKSKEGVTTPPKPYTEGQLITMMKTCGSSVEDEESKIILKEVE 518 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLT 579 GLGTEATRAGIIE L K+G++ K + T G+ L S+ M +P++TA WE L Sbjct: 519 GLGTEATRAGIIETLKKQGYIEVKRNKVSVTPKGEILCESVQGTMLAKPELTAKWEGYLR 578 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQA 606 +I ++Q F+ + LI +A Sbjct: 579 KIGKEQGSKDIFVSQTSEFIKDLIKEA 605 >UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_9BACT Length = 781 Score = 308 bits (788), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 203/609 (33%), Positives = 325/609 (53%), Gaps = 39/609 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L K ++ DG++E GNG VTW GHL+E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHL-KAGQRHDGYLE-GNGWAVTWAFGHLVELKEPEEYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W ++ LPIVP++++L+ R KQL +K+ EA EI+ A D REG+L+ +L++ Sbjct: 59 WKVSLLPIVPDQFELRARGDDGAKKQLETVKKLFGEAEEIICATDAGREGELIFRYILEW 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + + V+R I+ L A+ + +LR +F L +A R+ ADW+ G+N TR Sbjct: 119 ---SGCEAKPVKRLWISSLTGAAISKGFAKLREGKDFDTLHYAARCRSEADWIVGMNATR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +T+ +LS+GRVQTP+L ++V RD EIENF ++DF+E+ D +F Sbjct: 176 YFTV--EYGKRNLLLSLGRVQTPILAMIVGRDMEIENFKSEDFWELHTEC---RDTKF-- 228 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + G++ A+ + ++ GQP +V+ K E+ + PL F L+ LQ Sbjct: 229 -----------RHTGGKIQKEEEAKALFEKVDGQPLVVSDVQQKNENTNPPLLFDLTELQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-SVHAPD 357 E +R+G +A L I Q LYE K ITYPR+D RYL + ++ + ++ + Sbjct: 278 REMNRRYGFTADQTLRIAQNLYE-QKRITYPRTDSRYLSTDLQPTIGPLLERLKAIKEKE 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 + P + R DD KV HHAIIPT NL +E +VY+ I + + F P Sbjct: 337 IAPLELDKLSFGKRIVDDSKVSDHHAIIPTD-DLPRNLNADEERVYDAILVRLIAVFYPA 395 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTL------LGSKERDEENDGTPLPVVA--- 468 V +E ++ F A+ L EAGW+ L + SK++ + P P Sbjct: 396 CVKAVTTVEAKASEETFRARGTVLLEAGWQALYPQLFAIASKKKGAKGKAAPEPAAMPHF 455 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 + E + + + +T PP+ FT+ATLLS M + V+D++LK+ L+ G+GT ATR Sbjct: 456 QVGESNPHRPSIEKFKTNPPKRFTEATLLSLMETAGKIVEDEELKEALK-DKGVGTPATR 514 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCR 587 A IIE+L +R ++ +K + + ST +G+ L + E P++T WE L ++ + Sbjct: 515 ASIIEVLIQRKYVERKKKNLISTYSGRHLISLIQDERLKSPELTGDWEFRLKKVERGEQD 574 Query: 588 YQDFMQPLV 596 + FM +V Sbjct: 575 PKAFMSDVV 583 >UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q01NZ0_SOLUE Length = 1333 Score = 307 bits (787), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 209/617 (33%), Positives = 312/617 (50%), Gaps = 43/617 (6%) Query: 5 IAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLA 64 +AEKPS+AR IA VL KG+GF+ GNG VVTW IGHL AQP D ++ W Sbjct: 12 LAEKPSVARDIARVL-GAGTKGEGFLH-GNGYVVTWAIGHLAALAQPGEIDPQWRPWRRN 69 Query: 65 DLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQLA 122 LP++P +W L Q +KR L+ + + +V A D REG+L + Y+ A Sbjct: 70 TLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVCATDAGREGEL----IFRYIYEA 125 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V R I+ L P A+ + D LR +++ L +A R+RADWL G+N++RAY++ Sbjct: 126 AGCEKPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAARGRSRADWLVGMNLSRAYSL 185 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---VTPADERFTAI 239 Y LSVGRVQTP L ++V R+ + NFV +D+ EV A P + + Sbjct: 186 -----AYSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATFHPTGAPKESVYQGT 240 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRI-----SGQPAIVTSYNDKRESESAPLP-FS 293 W ++ + + + P NRI +GQ AI + D + AP P + Sbjct: 241 WFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESI--DAQTQRMAPPPLYD 298 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L+ LQ A + FG SAQ LD Q LYE HKLI+YPR+D R+L ++ V+ AI+ Sbjct: 299 LTELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVARTLPRVVAAIAE 358 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLM 412 +LL + + R DD KV HHAIIPT S+A L +E K+Y+LI R+ L Sbjct: 359 PYRELLAPGTGERPLGRRFVDDAKVTDHHAIIPTVTSAANAQLAPDERKIYDLICRRLLS 418 Query: 413 QFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTL------------LGSKERD 456 + D ++ + I ++ + + + GW+ L G+ + D Sbjct: 419 AWHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAPAKAKRAKSPGTADAD 478 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 P P +A G E ++++T+ P+ FT+ TLL+AM + + +K+L + Sbjct: 479 RGEQELP-PGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMETAGKTLDEKELSDAM 537 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 + T GLGT ATRA IIE+L KR ++ + G+ + +TD G L + P MT WE+ Sbjct: 538 KET-GLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVHPEVRSPIMTGQWEA 596 Query: 577 VLTQISEKQCRYQDFMQ 593 L +I + FM Sbjct: 597 YLHRIHRGNAQLDPFMH 613 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 307 bits (787), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 207/619 (33%), Positives = 331/619 (53%), Gaps = 26/619 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA+ L KG I + +++ +GH++E P DSR+ +W+ Sbjct: 5 LVIAEKPSVAQDIAEALGG-FPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHRQWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L++LPI+P + L+P +LN++ LH + I++A D REG+L+ ++ + Q Sbjct: 64 LSNLPILPSSFSLKPIQKHKDRLNLLLSLLHREDVDLIINACDAGREGELVFRYLIRFAQ 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + +QR + + A+ A LR E L +A++R+ +DWL GIN TRA Sbjct: 124 V----NKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAVSRSESDWLIGINGTRAL 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L N+ + SVGRVQTP L LVV RD+EI +F K ++E+ A + E + A W Sbjct: 180 TALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWEILATFRSKQGE-YKAKW 238 Query: 241 QPSEACEPYQDEE-GRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + +D R+ + + ++ + + IVT K +S PL + L++LQ Sbjct: 239 FSRNSQHEGEDNHPERIENEDQCQSIIEKCLNKEGIVTE-EKKVSQQSPPLLYDLTSLQR 297 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP--- 356 EA RFG SAQ L I Q LYE HKLITYPR+D ++LPE++ V+ +S H P Sbjct: 298 EANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYVPRVKEVLKNLS-HGPFET 356 Query: 357 ---DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 ++L Q V P N+ ++++KV H AIIPT L NE K+Y LI R++L Sbjct: 357 FAREILSQNWVQP--ANKIFNNQKVSDHFAIIPTTHKPT-TLNANEEKIYQLIVRRFLAT 413 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F P A + + + F + + L AGW + + + L + +G+++ Sbjct: 414 FYPPAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSNPAQNTEEDVLCPIEQGEKV 473 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 L E + ++T+PP HFT+ATLLSAM + V+D+ L++ + A GLGT ATRAGIIE Sbjct: 474 LNLAMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETLREAM-AKKGLGTPATRAGIIE 532 Query: 534 LLFKRGFLTKK-GRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRY 588 L + G++ ++ G+ + +T AL L + ++T WE L + +++ Sbjct: 533 GLIEDGYIRRQDGKALVATPKAFALIELLSAAQIQTLRSAELTGEWEFKLQMMEKEKYSQ 592 Query: 589 QDFMQPLVGTLYQLIDQAK 607 + FM+ + ++D+AK Sbjct: 593 EKFMEEIYQLTASIVDKAK 611 >UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q185E5_CLOD6 Length = 706 Score = 307 bits (787), Expect = 8e-82, Method: Compositional matrix adjust. Identities = 190/598 (31%), Positives = 309/598 (51%), Gaps = 43/598 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+ R IA VL + K +G+IE G V+TW +GHL+ A P++Y RY W+ Sbjct: 5 LVLAEKPSVGRDIAKVLGSKNEK-NGYIE-GPKYVITWALGHLVTLADPESYGERYKSWS 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLPI+P+ + KQ N +K ++ + EIV A D REG+L+ +++ Q Sbjct: 63 LEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIEKSQ 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++ ++R I+ +A++ +L+S E+ L SA+ARA ADW+ GIN TRA Sbjct: 123 V----KKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRAL 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T Y LS GRVQTP L ++++R+EEI NF K+++ ++ I T + IW Sbjct: 179 T-----TKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLEL-IATKGNSDIKFIW 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 ++ + E + ++ G ++ N + + +P + L+ LQ + Sbjct: 233 ND-------KNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQRD 285 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K FG SA+ L I QKLYE HK++TYPR+D RYL + + A+++ + Sbjct: 286 ANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKIC 345 Query: 361 QPVVDPD-IRNRCW-DDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFCPD 417 ++ + I N+ + D+ KV HHAIIPT + + + ++ E K+YNL+ +++L P Sbjct: 346 NRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSPP 405 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEK 477 + + I + F AK + GW+ K+ ++E++ +P V + D L + Sbjct: 406 FEYEQTTISATVEGEIFKAKGNKVINLGWKE--SYKDIEDEDEYESIPNVLEKDVLKVKG 463 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 ++ +T PP + + TLL+AM +GLGT ATRA IIE LF Sbjct: 464 LKITSGKTNPPPYLNEGTLLTAM-----------------EKNGLGTVATRADIIEKLFN 506 Query: 538 RGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 + KK + I+ T G+ L +P P++TA WE L IS+ + F+ + Sbjct: 507 SFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDM 564 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 307 bits (786), Expect = 9e-82, Method: Compositional matrix adjust. Identities = 221/602 (36%), Positives = 314/602 (52%), Gaps = 66/602 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I EKPS+A IA L KP R+ G++E G +VTW GHLLE + R Sbjct: 1 MKLVITEKPSVALDIARALGKPTRR-QGYLEVGE-YLVTWTYGHLLEIGEIAP-----KR 53 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNL DLPI PEK++ Q V+++ L A +++ GD REG+L+V E+L++ Sbjct: 54 WNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDAGREGELIVRELLEFTG 113 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R +V R ++ L V R + RLR +SEF L SALAR DW+ GIN+TR Sbjct: 114 Y----RGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNGDWIVGINLTRL 169 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ AG V SVGRVQTP L ++V+RD EIE F + ++ V A Sbjct: 170 VTL---KAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFEGEM------- 219 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + EE RL R AE VVN + S + V + +R E PL SL++LQ Sbjct: 220 ----KGVMLRNGEEARL-AREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTSLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-SVHAPD 357 EA +GLSA+ LD+ Q LYE KLI+YPR+D RYL E R V + + + + Sbjct: 275 REANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGE---GNRDLVKDVLRKLGRGE 331 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 L+P+ VD + R +D K+ HHAIIP R NL KVY+L+ R+++ F D Sbjct: 332 LVPR--VD-RVGKRVFDSSKLTDHHAIIPLDRPPE-NLPAIHRKVYDLVYRKFVGAFMDD 387 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEK 477 V+ + + + F+ + + + GW L ++ PL + + E+ E Sbjct: 388 YVYELQRVFIRLDGELFLVEGKRNLQLGWMELY-------PHEDNPLKIPS--GEVRKEW 438 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 + ERQT+PP FT+A+LL M + GLGT ATRAGIIE L + Sbjct: 439 VKAEERQTKPPARFTEASLLREMERL-----------------GLGTPATRAGIIETLLE 481 Query: 538 RGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQC---RYQDFMQ 593 RG++ ++G+ ++STD G+ L L + PDMTA WE L +I K+ YQ+FM+ Sbjct: 482 RGYVERRGKSLYSTDKGRELVDKLGDSKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFME 541 Query: 594 PL 595 + Sbjct: 542 GI 543 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 307 bits (786), Expect = 9e-82, Method: Compositional matrix adjust. Identities = 213/658 (32%), Positives = 334/658 (50%), Gaps = 63/658 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+AR I L + + F E G VVT +GH+LE PD + + +W Sbjct: 5 LVITEKPSVARDITRALGGFQNEKN-FFE-GPEHVVTSAVGHMLELVAPDGVEVQRGKWA 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +LP++P+ + L+P QL +IK+ + +++A D REG+L + YL Sbjct: 63 LVNLPVIPDHFDLKPIQQNESQLKLIKKLYARKDIDSVINACDAGREGEL----IFHYLI 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + V+R + + PQA+ +RLR +PL +A+ R+ +DWL GIN TRA Sbjct: 119 RHFKGSKPVRRLWLQSMTPQAIRDGFERLRDGETLLPLQRAAVCRSESDWLIGINATRAM 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L + G + +VGRVQTP L L+V R++EI++F ++++EVKA I A R+ W Sbjct: 179 TALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPREYWEVKA-IFAIASGRYEGYW 237 Query: 241 -----QP--SEACEP--YQDEEG-----RLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 QP + P +D+ G R+ + AE +V + + + V S K S+ Sbjct: 238 VDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIVAQCANREGRV-SETTKPSSQ 296 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P+ F L++LQ EA +RFG SA+ L I Q LYE HK++TYPR+D R LPE++ Sbjct: 297 QPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVLTYPRTDSRTLPEDYPKTVGT 356 Query: 347 VMNA--------------------ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP 386 +M + IS A +L + ++ R R +++ +V H AIIP Sbjct: 357 IMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYINGKNR-RIFNNAQVSDHFAIIP 415 Query: 387 TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGW 446 T + L E E ++Y L+ R ++ F P A F V + F + R L E+GW Sbjct: 416 TGEAPG-KLKEQERRIYELVTRCFIAAFYPPARFENTVRRTVVEHQTFETRGRVLIESGW 474 Query: 447 RTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVE-----RQTQPPRHFTDATLLSAMT 501 ++G KE +E LP +A + E+ E VE +QT+ P + +ATLLSAM Sbjct: 475 LQVMGRKESNE-----TLPPLASTAQDDSERAETVEIDLEGKQTKAPPRYNEATLLSAME 529 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHST-----DAGKA 556 G + ++D +L++ L+ GLGT ATRA IIE L + ++ + R + T Sbjct: 530 GAGKLMEDDELREALQGR-GLGTPATRAAIIEELIRNRYILRDARELIPTAKATTLLRLL 588 Query: 557 LFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF 614 + E+ T ++T WE L QI Q ++FM+ + +++ A++ V Q Sbjct: 589 RALKIDELTT-AELTGEWEKKLKQIESDQFSSEEFMRHIRRMTADIVEAARQCDVDQI 645 >UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6_OPITP Length = 939 Score = 305 bits (782), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 211/635 (33%), Positives = 325/635 (51%), Gaps = 43/635 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-YARW 61 L IAEKPS+A +A L K ++GD + + VV++ +GHL+E P+ D + Y W Sbjct: 4 LVIAEKPSVAADLARALGKIPKQGDHY--ENDQYVVSYAVGHLVELEMPEDIDKKKYGFW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 L LPI+PEK+ L+P + N +K+ L + +++A D REG+L + YL Sbjct: 62 RLETLPIIPEKFGLKPIEESKDRFNALKKLLARKDIELVINACDAGREGEL----IFAYL 117 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + + + + A LR + L +A R+ +DWL GIN TRA Sbjct: 118 YQLTKCKLPVKRAWMQTMTAEGIREAFAHLRDGEQMAGLAAAARCRSESDWLIGINGTRA 177 Query: 180 YT--ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 T + G AG V SVGRVQTP L +V R+ EI NF + ++++ A + R+ Sbjct: 178 LTKRMFGSRAG--NVASVGRVQTPTLAIVYSRELEIRNFKPRAYWQITATFEV-TNGRYE 234 Query: 238 AIWQPSEACEPYQDEEGR---LLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 +Q + + DE R + + +AE +V GQP K ++ AP + L Sbjct: 235 GTYQRPDFKKSDADEHDRVDRIWEQAVAEAIVAACQGQPPAAVREEKKASTQIAPRLYDL 294 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG-RHAVMN---A 350 + LQ EA RFGLSA+ L I Q LYE HK+ITYPR+D R LPE++ R + N Sbjct: 295 TTLQREANNRFGLSARRTLQIAQALYERHKMITYPRTDSRALPEDYIPTVRETLKNLHGP 354 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 ++ HA +L Q V P+ R +++ ++ H AIIPTA A +L E EAKV+++IAR++ Sbjct: 355 LAPHAQQVLDQGWVRPN--RRIFNNAQISDHFAIIPTAH-EAKHLDEMEAKVFDMIARRF 411 Query: 411 LMQFCPDAVFRKCV-IELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT-PLPVVA 468 + F P A F I + +F + + L GW + G +++ G+ LP ++ Sbjct: 412 VAAFFPPAEFDITTRISTVAGRHEFKTEGKVLTVPGWLAVYGRTTVEDDAPGSKSLPALS 471 Query: 469 KGDELLCEKGEVVERQ------------TQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 D +G+ Q T+PP +T+ATLLSAM G + V D+DL + + Sbjct: 472 DADRATVARGDDAPAQAKTLDPVLHAETTKPPPRYTEATLLSAMEGAGKLVDDEDLAEAM 531 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTA 572 + GLGT ATRA I+ L + ++ + R + T + L L + T P MT Sbjct: 532 KER-GLGTPATRADTIDGLINQKYMERGQRELIPTAKAEQLLQFLSAVHTDALTSPAMTG 590 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 WE L QI + ++FMQ +V ++D+ K Sbjct: 591 EWEFKLRQIEHGKFSREEFMQEVVEQTKGIVDRVK 625 >UniRef50_D1AS14 DNA topoisomerase type IA central domain protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AS14_SEBTE Length = 764 Score = 303 bits (777), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 203/635 (31%), Positives = 327/635 (51%), Gaps = 30/635 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEK ++A AIA + DG+++ G+ +TW GHLL +P+ YD ++ + Sbjct: 1 MKLIIAEKRNVATAIATAIDGAQETKDGYVKKGD-YYITWASGHLLSLKEPEDYDPKFQK 59 Query: 61 WNLADLPIVPEKWQLQP-RPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 WN+ DLP W+L+P KQLN+IK L E S ++HA DPD EGQL+ DE+L Sbjct: 60 WNIPDLPFNFPNWELKPINAGSKKQLNIIKDLLKECSGVIHACDPDDEGQLIGDEIL--- 116 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L + ++ V+R LIND N + + + +L N ++ L +SA AR AD + GIN++R Sbjct: 117 -LYHDYKKPVERMLINDNNTEYIRKLFTKLEDNRKYESLGISAAARRIADAIIGINLSRF 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 Y+ L VGRV+ P LGLVV RD IEN + + + ++ I D+ Sbjct: 176 YS-----CKSSKTLHVGRVKAPTLGLVVNRDYAIENHIKQLHYILRI-IANNNDKDNNIT 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + +E+ ++ E V I+ + K +++ PL F++ LQ Sbjct: 230 FTFQKNANTPVNEDKLIIDLDYIEKVQAEIADIKDYKVNVTSKILTKNPPLVFNIDKLQA 289 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +F +AQ VL+I Q L TH++ITY RSD +YL EEHF ++ I + L Sbjct: 290 YCNNKFSYTAQEVLEITQVLQATHQIITYNRSDSQYLNEEHFQEAPQLIEIIKENLN--L 347 Query: 360 PQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 +D + +++ +D KV AHH IIPT R LTE E VY +IA YL+QF P Sbjct: 348 SLDNIDTNRKSKVFDSSKVTAHHGIIPTHTRFDLSKLTEKERNVYQVIAEFYLVQFMPPE 407 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE-- 476 ++ + F R + + G++ L S ++E ++K ++ L + Sbjct: 408 KLKETTGIFKVKDYDFKTTDRTVQDLGYKKFLNSINEEKE--EEEKSNISKFEDRLYDFV 465 Query: 477 --KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGTEA 526 + R+T+PP+ +T+ATL+S MT IA+++++ ++K+IL D +GT A Sbjct: 466 NFATPIDTRETKPPKPYTEATLISDMTSIAKYIKNPEIKEILLRKDKDKEGAKGSIGTPA 525 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS-LPEMATRPDMTAHWESVLTQISEKQ 585 TRA +E L G+L +KG+ I +T+ GK +++ LP+ D+TA W + I Sbjct: 526 TRASTVEELINDGYLERKGKQIRATEKGKNFYNNVLPDEIKTADLTALWWVIQEDIIAGT 585 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAP 620 D + ++ Q ++ K +R ++ P Sbjct: 586 KTITDLTDSVFKSVIQAMETNKDIKIRHKDDVICP 620 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 303 bits (775), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 219/627 (34%), Positives = 318/627 (50%), Gaps = 45/627 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS A AIA L R+ DG++E +++W IGHL+E P+AYD R+ RW Sbjct: 6 LIIAEKPSAAMAIAQALGGFQRR-DGYLESAE-YLLSWAIGHLVELLPPEAYDPRWKRWT 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + LPI+PE + L P Q + R +A +V+A D REG+L + Y+ A Sbjct: 64 METLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNACDAGREGEL----IFRYICAA 119 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V R ++ L P A+ A ++ + L SA RA DWL GIN TRA+T+ Sbjct: 120 AGLEKPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCRAEGDWLVGINATRAFTV 179 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + +LS GRVQTP L +VVRR+ EIE+F + ++EV A TP +T W Sbjct: 180 -----KFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRTPDGREYTGKW-- 232 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + RL AE VV R+ Q V + +++ +E P F L++LQ EA Sbjct: 233 ------FGPDGDRLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTSLQREAN 286 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQP 362 +R+GL+A L Q LYE K ITYPR+D RYL A++ A+S + Sbjct: 287 RRYGLTAAATLKAAQALYEA-KHITYPRTDSRYLSRALVPQLPALVRALSARSDLAALAA 345 Query: 363 VVDPDI----RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 D R DD KV HHAI+PT+ +LT EAK+Y+LI R++L QF PDA Sbjct: 346 GADLSRVGFGNRRVVDDAKVTDHHAILPTSEVPR-SLTGAEAKIYDLIVRRFLAQFYPDA 404 Query: 419 VFRK-----CVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-------LPV 466 F + CV EL +F ++ R L + GWR + R LP Sbjct: 405 RFLEQEVVTCVGEL---PDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEGLQLLPP 461 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + G+ + E E+ T+PPR +T+ATLLSAM R + D+ L++ ++ GLGT A Sbjct: 462 LRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKG-HGLGTPA 520 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFH----SLPEMATRPDMTAHWESVLTQIS 582 TRA IIE L + G++ + R + T G+ L + E+ P++T WE + I Sbjct: 521 TRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHRIAGIQ 580 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRT 609 + FMQ + +L+++ + T Sbjct: 581 SGEYDDARFMQEIRELTARLVERIRAT 607 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 303 bits (775), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 202/614 (32%), Positives = 314/614 (51%), Gaps = 66/614 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+A+ IA VL K ++E G VVTW +GHL+ A+P+ YD +Y WN Sbjct: 4 LVLAEKPSVAKEIARVLG-CSSKNKSYME-GPDYVVTWALGHLVTLAEPEDYDPKYKTWN 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP++P K L+ + Q + + + E++ A D REG+L+ +++ + Sbjct: 62 LEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIATDAGREGELVARWIMELVH 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ +R I+ +A++ L+ ++ L SA+ RA ADWL G+N+TRA Sbjct: 122 W----RKPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVCRAEADWLIGLNVTRAL 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ Y L+ GRVQTP LG ++ R++EI F ++ ++ V A + F A+W Sbjct: 178 TV-----KYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAELGA-----FQALW 227 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + ++ + +GR+ R AE V+ R+ G+ A V ++SE P F L+ LQ E Sbjct: 228 RQND------NHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLTELQRE 281 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV--HAP-- 356 A KR G SA+ ++ QKLYE HKL+TYPR+D RYL + + +++V +AP Sbjct: 282 ANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGPYAPLA 341 Query: 357 -DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 LL + + R DD KV HHAIIPT ++ L+ +E K+Y+LI R+++ F Sbjct: 342 RKLLRGQLT---VTKRFVDDSKVSDHHAIIPTDEYVNLSALSNDERKLYDLIVRRFIALF 398 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG-------SKERDEENDG------ 461 P + + + L + + K AK + + GW+ L G + E DEE +G Sbjct: 399 YPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGRGEDKS 458 Query: 462 TP---LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 TP LP + +G + ++ + E +T PP +T+A+LLS M Sbjct: 459 TPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKM-----------------E 501 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 GLGT ATRA IIE L + + + T GK L + + P++TA WE L Sbjct: 502 KHGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVDELRSPELTAKWEREL 561 Query: 579 TQISEKQCRYQDFM 592 I+ Q + FM Sbjct: 562 ELIAHGQGDAKRFM 575 >UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1_CLOD6 Length = 696 Score = 299 bits (766), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 201/618 (32%), Positives = 313/618 (50%), Gaps = 52/618 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS+A+ IA VL +K DGF+ G+G +V+WC+GHL+ A+ AY +Y + Sbjct: 1 MILVIAEKPSVAQTIAAVLGVKEKK-DGFL-TGSGYIVSWCVGHLVGLAEAAAYGEQYKK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDY 118 WN LPI+P++W+ KQ +K +H A SE+V+A D REG+L+ V + Sbjct: 59 WNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEM 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ ++R I+ + A++ RL++ E+ L SAL RA+ADWL GIN TR Sbjct: 119 AGC----KKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +++L Y L+VGRVQTP L ++V RD I F + ++ V+ A Sbjct: 175 LFSVL-----YNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVR-----------LA 218 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + A E R+ ++ A+ + A+ TS ++++ + P F L++LQ Sbjct: 219 LSGAEAASE-------RISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQ 271 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA FG +A+ LD+ Q LYE +L+TYPR+D YL ++ ++ + P + Sbjct: 272 REANCLFGYTAKQTLDLAQALYE-KRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFM 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT---ARSSAINLTENEAKVYNLIARQYLMQFC 415 + P++ + + KKV HHAIIPT A++ L E+E + + + +M Sbjct: 331 AGKDFT-PELA-KVLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATA 388 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGW-------RTLLGSK-ERDEENDGT--PLP 465 F + A F A+ + + GW R +L SK E D+ + T LP Sbjct: 389 APHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLP 448 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 +G +V E T PP+ +A+LLSAM D D ++ GLGT Sbjct: 449 PFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAER-----KGLGTP 503 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ 585 ATRA +IE L K GF+ +KG+ + T G L LP+ T P +TA WE+ LTQI++ + Sbjct: 504 ATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGK 563 Query: 586 CRYQDFMQPLVGTLYQLI 603 FM+ + +L+ Sbjct: 564 ADPAAFMKGIEDMARELV 581 >UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0_STRPF Length = 577 Score = 299 bits (765), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 199/616 (32%), Positives = 323/616 (52%), Gaps = 53/616 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A IA ++ RK +G+ E GNG +V+WC+GHL++ A PD D ++ + Sbjct: 5 MKLVIAEKPSVAVTIAKIIGARTRK-NGYYE-GNGYIVSWCVGHLIQMASPDKIDEKWKK 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDY 118 W + +LPI+PE++ + S KQ V+K+ L++ + +++A D REG+L+ V + Sbjct: 63 WTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNINIVINACDAGREGELIFRLVYNQ 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++++QR I+ + +A+E L+ +F L SA ARA ADWL G+N++R Sbjct: 123 AKC----KKKIQRLWISSMENEAIEDGFRNLKDGEKFEDLYRSASARAIADWLVGMNLSR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 Y+ + Y+ SVGRVQTP L L+ +RD EI F + ++ V D + Sbjct: 179 LYSCI-----YKETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTV--------DLSYGG 225 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + S+ R+ +AE ++N + + ++T DK S P+ L+ LQ Sbjct: 226 LKLVSD----------RIDRIEVAEQLLNLLEDE-IVITEVEDKEVSTKPDKPYDLTTLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA K FG SA + L++ Q LYE KLITYPR+D RYL ++ ++N + L Sbjct: 275 REANKYFGYSANDTLNLAQALYE-KKLITYPRTDSRYLTDD-------MVNTMKELLEGL 326 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR--SSAINLTENEAKVYNLIARQYLMQFCP 416 ++ ++ KV H+AIIPT A +L++ E+KVYNLI + L+ C Sbjct: 327 EEDFKLNKSNFKSIFNSSKVTDHYAIIPTISGIGKAKDLSDKESKVYNLI-KDKLLASCS 385 Query: 417 DAV---FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 D + RK E D K F A + + + G+ L K +E LP V GD++ Sbjct: 386 DNLKESSRKIRYEYD--KFNFNASGKTIIDEGYTKYL--KAYGKEKQENELPDVKTGDKI 441 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + E+ T+ P H+ + TLL AM DKD+ ++ R GLGT ATRAGIIE Sbjct: 442 KLTSKNISEKFTKAPSHYNEDTLLKAMENAGVESLDKDI-EVERK--GLGTPATRAGIIE 498 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L + + + + + T+ G L + + + T+ WE L +I+ + +DF++ Sbjct: 499 NLIHKELIRRDKKNLLVTEKGNRLVSIVEDKFKSAETTSEWEMKLAKINSGEVDKEDFLR 558 Query: 594 PLVGTLYQLIDQAKRT 609 + ++ +L+D+ K Sbjct: 559 EIEDSIRELVDRYKNN 574 >UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP3_BACSK Length = 729 Score = 298 bits (762), Expect = 6e-79, Method: Compositional matrix adjust. Identities = 206/619 (33%), Positives = 322/619 (52%), Gaps = 41/619 (6%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 + +AEKPS+AR IA VL ++KG+G++E GNG ++TW +GHL+ A P+ Y +Y W Sbjct: 4 KAVLAEKPSVARDIARVLG-CNQKGNGYLE-GNGYIITWALGHLVTHADPEHYGKQYKTW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 L +LP++P++ +L KQ + +K L+ + E+V A D REG+L+ +L+ Sbjct: 62 KLEELPMLPKRLELVVIKQTAKQFHAVKHVLNRQDVGEVVIATDAGREGELVARWILEKA 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ V+R I+ + +A++ +L+ + L +A ARA ADW GIN TRA Sbjct: 122 HV----KKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAAAARAEADWYVGINGTRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T + LS GRVQTP L ++ R+E I FV K + I + T Sbjct: 178 LTT-----KHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHT----ISVETKDGVTFR 228 Query: 240 WQPSEACEP--YQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 W + E + D+ + L L + + ++ S N K + P + L+ L Sbjct: 229 WADRRSKEERIFDDKRAKTLQEKLQQSAI--------VIDSVNAKTKRTPPPPLYDLTEL 280 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA KRFG SA+ L Q+LYE HK +TYPR+D RYL + ++A+ V Sbjct: 281 QREANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDVQPFR 340 Query: 358 LLPQPVVDPDIRN---RCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQ 413 + + N + +D KV HHA+IPT + SA +++ EAK+Y+LI R++L Sbjct: 341 KMVANAKKQGLANAKRQMVNDAKVSDHHALIPTEQPQSASAMSDKEAKLYHLIVRRFLAN 400 Query: 414 FCPDAVFRKCVIELDIAKGKFV-AKARFLAEAGWRTLLGSKERDEENDGTP--LPVVAKG 470 F P + +E A G+ + AK L AGWR +E EE++ LP ++KG Sbjct: 401 FFPPSESELTSVEA-TANGELLRAKGERLVSAGWR----GQETGEEDEALARLLPAMSKG 455 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD--LKKILRATDGLGTEATR 528 D+ + + + +T PP F + TLL+AM A+ ++ KD +KK L G+GT ATR Sbjct: 456 DKKAVKWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVATR 515 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A IIE LF ++ KKG+ ++ T GK L +P P +TA WE L +I + + + Sbjct: 516 ADIIEKLFSSFYIEKKGKDLYITSKGKQLLELVPAELKSPALTAEWEQRLEKIVQGKEQK 575 Query: 589 QDFMQPLVGTLYQLIDQAK 607 Q F+ + ++ Q K Sbjct: 576 QMFIAEMKEYAKAVVAQVK 594 >UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QH35_DESAH Length = 855 Score = 296 bits (759), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 191/612 (31%), Positives = 323/612 (52%), Gaps = 41/612 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + EK S+A A L ++K DG+ E G+ V+TW +GHL+E +PD YD+ +W Sbjct: 4 LILTEKFSVASDFAKALGVKNKK-DGYFE-GDAHVITWAVGHLVELFEPDDYDAGLKKWR 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP++PE+++ +P +Q IK L + I+ A D REG+++ +L L+ Sbjct: 62 VETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTIL--LE 119 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 ++++ R + L P+ V +++L+ +++ L + R +DWL G+N+TR Sbjct: 120 SGFRDKERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRL 179 Query: 180 YTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 T+ LG + SVGRVQT VL ++V R E E+F+ + ++ K + + R+T Sbjct: 180 MTVRLG------DLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKV-LFSGDKGRWTG 232 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESESAPLPFSLSA 296 W ++++E R+ +P A+ ++ R + P +V S + + E PL FSL+ Sbjct: 233 RW--------FKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTD 284 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA RFG A+ L I Q LY+ K ++YPR+D + L + V+ + P Sbjct: 285 LQQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACP 344 Query: 357 DLLPQPVVDP---DIRNR-CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 DL VDP + NR ++D K+ HHA+IP S + +E +++L+ R++ Sbjct: 345 DLFA--FVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEA-ASRDEKLLFDLVVRRFAA 401 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F PD F + AK F + + + + GW+ + G+ RD+ + +P + +GDE Sbjct: 402 AFHPDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRDKA-EAEIIPPLVEGDE 460 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 EK E E+QT PP ++D+ LL MT R+V ++++K++ R G+GT++TRA II Sbjct: 461 GAVEKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQII 520 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSL-----PEMATRPDMTAHWESVLTQISEKQ-- 585 E L RG++ + G+ + +TD G L L + T P+ TA WE L I+ + Sbjct: 521 ETLISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGS 580 Query: 586 -CRYQDFMQPLV 596 R+ D ++ V Sbjct: 581 DIRFLDHIKAFV 592 >UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0YH06_9FLAO Length = 695 Score = 295 bits (756), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 205/623 (32%), Positives = 313/623 (50%), Gaps = 65/623 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+ IAEKPS+AR IA +L H K DG++ GNG VTW +GHL+ P+ Y R Sbjct: 1 MKAIIAEKPSVAREIAQLLG-AHEKKDGYL-SGNGYCVTWALGHLISLGMPEDYGIR--G 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + A LPI P + L P+ PS KQLN I++ + + S I+ A D REG+ Sbjct: 57 FKKASLPIFPNPFILTPKKLKKAKGYEPDPSALKQLNTIQQVIKQCSSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YLQ + +R I+ L +A++ L+ F L +A AR+ AD Sbjct: 117 LIFRYIYHYLQC----NKPFERLWISSLTEKAIQDGFKNLQPGDAFDGLYQAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK-AHI 228 WL GIN T+A TI G Q V S+GRVQTP L L+ +R + +NF + +F+++ +H Sbjct: 173 WLVGINATQALTI----GGNQDVYSLGRVQTPTLALICQRFLQHQNFTKQKYFQIQLSHR 228 Query: 229 VTPADERFTAI----WQPSEACEPYQ---DEEGRLLHRPLAEHVVNRISGQPAIVTSYND 281 D FT++ W+ + E Q + EGR AIV + Sbjct: 229 KEYTD--FTSLSLLQWEEKKQAEQIQKIIEREGR------------------AIVEDVSV 268 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K E +PL F L+ LQ EA ++ GLSA VL Q LYE + ITYPR+ +Y+PE+ + Sbjct: 269 KTVQEQSPLLFDLTELQKEANRKLGLSADEVLQTAQSLYE-KQFITYPRTGSKYIPEDLW 327 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRN---RCWDDKKVDAHHAIIPTARSSAINLTEN 398 ++ ++ P + N R +D KV HH ++ T ++ + L+ Sbjct: 328 TDIPELVRILNQTEP--FKAAITHLKFGNFNKRIVNDVKVTDHHGLLITTKTPSA-LSAT 384 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 E +Y++IA + L + I++ + +F K + GWR + G +E Sbjct: 385 EKAIYDMIAYRLLESLSHTCTKQVTQIQIKVHHYEFQIKGSKILNKGWRAIKGILSDNEN 444 Query: 459 N-----DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 + D T LP GDEL K E++E+ TQPP+ +T+A LLS M R +++K+ + Sbjct: 445 SNNANEDLTELPEFKIGDELKISKTELLEKTTQPPKLYTEADLLSVMENAGRSIENKEDQ 504 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDMTA 572 K L + G+GT ATRA IIE L R ++ +K + +H TD G +++ + + MTA Sbjct: 505 KAL-SNIGIGTPATRASIIETLLSRNYIVRKSKTLHPTDKGLQVYNLVKDKKIANVQMTA 563 Query: 573 HWESVLTQISEKQCRYQDFMQPL 595 WE L +I + + FM + Sbjct: 564 EWEIALDKIEKGELNKTQFMNDI 586 >UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C0FPK2_9FIRM Length = 680 Score = 295 bits (754), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 203/620 (32%), Positives = 303/620 (48%), Gaps = 55/620 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPS+A++IA VL R DG++E G G +V+WC GHL E A Y++ A+ Sbjct: 1 MRLVIAEKPSVAQSIAAVLGAKSRH-DGYLE-GGGYIVSWCFGHLAELADAAVYNAVDAK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W LA LPI+P ++ R KQ ++++ + + +E+V+A D REG+L+ V Y Sbjct: 59 WTLAALPIIPTSFRFIVRSEKQKQFDILRELVRREDVAEVVNACDAGREGELIFRTV--Y 116 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 K + R I+ + A+ +LRS ++ L SAL RA+ADWL GIN TR Sbjct: 117 CLAGCSK--PILRLWISSMEDDAIRSGFQQLRSGRDYDGLHQSALCRAKADWLVGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++++ Y L++GRV +P L L+V+R+ EI FVA+ F+ V+ PA Sbjct: 175 YFSLM-----YGRTLNIGRVMSPTLALLVQREAEISAFVAEPFYTVQLDCGFPAT----- 224 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 R+ R A+ + N G+ V S K +SE AP + L++LQ Sbjct: 225 --------------TDRMKDRKDADAIANACKGKTVTVKSVERKEKSEKAPALYDLTSLQ 270 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +A + G ++Q LD Q LYE KL TYPR+D YL ++ ++ A + Sbjct: 271 RDANRVLGYTSQQTLDYLQALYE-KKLCTYPRTDSHYLTDDMEGSVPGLVAAAAAACGVE 329 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE---NEAKVYNLIARQYLMQFC 415 P + + KKV HHAI+PT + +++ E +V L A+ L Sbjct: 330 KPPTICAKQV----CSSKKVTDHHAIVPTISAEKVDMASLPLGEREVLKLAAKGLLRAVD 385 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVVAKGDELL 474 + + VI +D A F AK + + GW+ + E+ + P LPV + L Sbjct: 386 EPHRYAETVITVDCAGQSFTAKGKTVLAPGWK-----RYEQEQTEAVPALPVATENQTLS 440 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 V +T PP+HFT+ TLL+AM + D ++ G+GT ATR+GIIE Sbjct: 441 VSAASVKTGKTTPPKHFTEDTLLAAMENAGKEDMPDDAER-----KGIGTPATRSGIIEK 495 Query: 535 LFKRGFL----TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 L GF+ +KK + T G AL LPE P +TA WE L +I + Sbjct: 496 LVSSGFVERRKSKKITNLLPTSTGTALITVLPEQLQSPQLTAEWEHRLKEIERGEIAPDS 555 Query: 591 FMQPLVGTLYQLIDQAKRTP 610 FM + L +L+ K P Sbjct: 556 FMDGIAAMLNELVQTYKPIP 575 >UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q099E1_STIAU Length = 1504 Score = 290 bits (741), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 205/654 (31%), Positives = 318/654 (48%), Gaps = 62/654 (9%) Query: 5 IAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLA 64 +AEKP++AR IA L R G+G+ GNG VVTW IGHL+ AQP + RW+ Sbjct: 34 VAEKPAVARDIARALGATQR-GEGWFR-GNGYVVTWAIGHLVGLAQPHEMHPAWKRWHRE 91 Query: 65 DLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQLA 122 LP++P W L + Q V++ ++ E S +V A D REG+L + Y+ A Sbjct: 92 QLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGEL----IFRYIYEA 147 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R+ V+R ++ L A+ L+ + L +A R+RADWL G+N++R YT+ Sbjct: 148 AGCRKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYTL 207 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV-----TPADERFT 237 LSVGRVQTP L ++V R+ I +FV +D+ EV A PA ++ Sbjct: 208 -----ACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQYR 262 Query: 238 AIW--QPSEACEPYQDEEGRLLHRPLAE-----HVVNRISGQPAIVTSYNDKRESESAPL 290 W + P E R R A+ V+ R+ A++ S + + + PL Sbjct: 263 GTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPPL 322 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 + L+ LQ A + +G SAQ L++ Q LYE HKL++YPR+ R+L V+ A Sbjct: 323 LYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVRA 382 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQ 409 I LL + + R DD KV HHAIIPTA S L +E ++Y L+ R+ Sbjct: 383 IRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCRR 442 Query: 410 YLMQFCPDAVFRKCVIELDIAK----------GKFVAKARFLAEAGWRTL-LGSKER--- 455 L + + V+ + ++ +F + + GW+ L +G +R Sbjct: 443 LLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPPK 502 Query: 456 -----------------DEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLL 497 DE D LP V+A+G + E E V+++T+PP TDA+LL Sbjct: 503 GREGKGPKEEGEGKEPEDEPQD---LPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLL 559 Query: 498 SAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKAL 557 +AM R + +K+L ++ T GLGT ATRA IIE+L +R +L ++G+ + T+ G L Sbjct: 560 TAMETAGRTLDEKELADAMKET-GLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRL 618 Query: 558 FHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 + P MT WE+ L +I Q Q F++ + + +++ + P+ Sbjct: 619 IQVVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPM 672 >UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium hafniense RepID=B8G1K2_DESHD Length = 777 Score = 286 bits (733), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 192/631 (30%), Positives = 318/631 (50%), Gaps = 44/631 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY---DSRYA 59 L IAEKPS AR A L ++ +G+ E + +++WCIGHL E P+ Y Sbjct: 5 LIIAEKPSQAREYAKTLGVKGKR-EGYFE-NDEYIISWCIGHLFELKAPENYMDLPKVGK 62 Query: 60 RWNLADLPIVPE--KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 RW++ LP++P ++Q + KQ V++ L E +++ D DREGQLL EV Sbjct: 63 RWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEV 122 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 D A ++ + R I+ L +A+ + +LR E L + R+ DW +G+N Sbjct: 123 WD----AVGSKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMN 178 Query: 176 MTRAYTILGRN----AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 +T +T L + V+S+GRVQTP L LVV ++ IENFV + EV+A + Sbjct: 179 LTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASG 238 Query: 232 ADERFTAIWQPSEACEPYQDEEG----RLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 + P+ +++E +L + +V ++ G+P + S DK E Sbjct: 239 QGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEP 298 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL F L++L + A+KR+G A+ VL I Q LYE K ITYPR+DC YLP + + Sbjct: 299 HPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYE-KKAITYPRTDCNYLPPD-------M 350 Query: 348 MNAISVHAPDLLPQPV---VDPDIRNRCWDDKKV----DAHHAIIPTARSSAINLTENEA 400 + + VH L P V + N K+V AHHAIIPT NL+ +E Sbjct: 351 LPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIPNLSPDER 410 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 K++ +I ++L + P A + + + + + F+ K + L E+GW+ + + E+ E Sbjct: 411 KIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENT-EKYTEGS 469 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 G LP++ + +E++ + ++++T+PP+ +T L+ AM G + ++D+ L++ L+ Sbjct: 470 GLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKG-K 528 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR------PDMTAHW 574 GLGT ATR IIE L RG+L ++ + + T G L + E R +MT Sbjct: 529 GLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQM 588 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 E L Q+ + +M+ + + +I++ Sbjct: 589 EYELAQVERGELPLSRYMEKVEEAIRGIIEE 619 >UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_9BACT Length = 817 Score = 286 bits (732), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 206/642 (32%), Positives = 317/642 (49%), Gaps = 79/642 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L R G GF+E GNG VTW GH++E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHLGATKR-GVGFLE-GNGWAVTWAFGHMVELQEPEDYKPEWKA 58 Query: 61 WNLADLPIVPEKWQLQPRPS-----VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L+ LPI+P + L+PR S QL IK+ +A EI+ A D REG+L+ + Sbjct: 59 WRLSTLPIIPADFALRPRASDPDGTARAQLETIKKLFLDADEIICATDAGREGELIFRYI 118 Query: 116 LDYL---QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 + L P + V+R I+ L +A+E+ L S++ L +A R+ ADW+ Sbjct: 119 YTWTGCEALPPPLAKPVRRLWISSLTNEAIEKGFQNLAPGSDYDRLYHAARCRSEADWIV 178 Query: 173 GINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N TR +T+ GR +LS+GRVQTP+L ++V RD ++E+F +DF+EV + Sbjct: 179 GLNATRFFTVEYGRR---NLLLSLGRVQTPILAMIVGRDLDVEHFKPEDFWEVHT-LCRS 234 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 A + TA G+ + A+ +V+RI+G ++ + K PL Sbjct: 235 ATFKHTA---------------GKFTVQTEAQAIVDRITGHELVIKNVTKKNALTHPPLL 279 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 + L+ LQ + KR GL+A L + Q LYE+ K +TYPR+D YL + +++ + Sbjct: 280 YDLTGLQRDMNKRHGLTADQTLRLAQSLYES-KHLTYPRTDSCYLSTDIQPTIGPLLDRL 338 Query: 352 SVHAPDLLPQPVVDPD-----IRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLI 406 L P + D R DDKKV HHAIIPT +LT +EAKVY+ + Sbjct: 339 RA----LKPAEIGKLDTGALAFSKRIIDDKKVSDHHAIIPTNVLGG-DLTGDEAKVYDAV 393 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG--------------- 451 + + F P + +E + A F A+ L + GW+ L G Sbjct: 394 LTRLIAVFYPPCIKAVTTVEAESAGEPFRARGTVLVDPGWQALYGGDVSDDDAGTGTKAK 453 Query: 452 --------------------SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHF 491 +K+ D + LP +G+ E + + +T P+ F Sbjct: 454 KASKNAAKKDADENESGESDAKDSDAADSAQQLPDFQEGERNPHEP-SLPQFKTSAPKRF 512 Query: 492 TDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHST 551 +A+LL M + V D+ LK+ L+ G+GT ATRA IIE+L RG++ +K + + ST Sbjct: 513 NEASLLQLMETAGKIVTDETLKEALK-DKGVGTPATRAAIIEVLITRGYVERKKKNLIST 571 Query: 552 DAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 D+G+AL + E P++T WE L QI + + FM Sbjct: 572 DSGRALISLVQDERLKSPELTGDWEYRLRQIERGEYEPRVFM 613 >UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein n=2 Tax=Pedobacter RepID=C6XWV5_PEDHD Length = 608 Score = 285 bits (730), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 195/601 (32%), Positives = 325/601 (54%), Gaps = 48/601 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+ R +A V +K DG+IE G G TW GHLL+ A P Y + Sbjct: 1 MKIVIAEKPSVGRELAKVFGATTKK-DGYIE-GKGYSFTWAFGHLLQLAPPQEYG--FIG 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 W LP++P+K++L R P V KQL++IK+ EA+EI+ A D REG+ Sbjct: 57 WRRQHLPMLPKKFKLAIRKIKTKDGMVEDPGVRKQLDIIKKLFDEATEIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L+ ++ +R I+ +A++ L+ +++ L SA R+ +D Sbjct: 117 LIFRYIYYFLKC----KKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N T+A +I +AG + VLS+GRVQTP L ++ R EI+NFV + ++++ + Sbjct: 173 WLVGMNATQALSI---SAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQLD 229 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 + F A+ S + ++E LL + E V + S I+ S K E P Sbjct: 230 KDG-QLFRAM---SVSNFDKKEEAEELLAK--IEDVASGFSNGGKIL-SVEAKPRKEPPP 282 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L LS+LQ EA KR G +A L + Q LYE+ KL+TYPR+ RY+ ++ FAG A+++ Sbjct: 283 LLHDLSSLQQEANKRKGFTADQTLSLLQGLYES-KLVTYPRTGSRYIGDDIFAGVPALID 341 Query: 350 AISVH------APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVY 403 + H A LL P + R + KKV HHAI+PT S L ++ VY Sbjct: 342 KVRGHKDFGKQAEFLLTVP-----LNKRSVNAKKVTDHHAILPTGES-PYQLNGDKQAVY 395 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLLGSKERDEENDGT 462 +++ + + F + V K + ++ + G F+A + AGWR++ + +++++ Sbjct: 396 DMVVGRMIEAFHQECV--KEITKISVESGSLFIANGTVIRAAGWRSVFNESDEEKKDEDN 453 Query: 463 P-LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 P LP + KG+EL ++E+QT+P + +A+LL A+ + ++D++L+ ++ + G Sbjct: 454 PALPKLKKGEELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDS-G 512 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDMTAHWESVLTQ 580 LGT ATRA IIE L R +++++ R + T G A++ + + + ++T WE L + Sbjct: 513 LGTPATRAAIIETLISREYVSREKRNLVPTTKGLAVYDVVKDQKIAQAELTGQWEKRLEE 572 Query: 581 I 581 I Sbjct: 573 I 573 >UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiaceae RepID=B2UQJ6_AKKM8 Length = 869 Score = 285 bits (729), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 195/633 (30%), Positives = 313/633 (49%), Gaps = 46/633 (7%) Query: 3 LFIAEKPS----LARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 L IAEKPS LAR + L K R G + ++T +GHLLEQ +P + + Sbjct: 5 LIIAEKPSVATDLARVLGKELGKFTRDKSGAFYQNDRAIITSAVGHLLEQKKPMTEEGKS 64 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH-----EASEIVHAGDPDREGQLLVD 113 W LP++P K++L+P + + + +K+ L + +EIV+A D REG+L+ Sbjct: 65 LPWKFDYLPVIPRKFELEP---IKQSEDRLKKVLQLARSKDVTEIVNACDAGREGELIFH 121 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 + Y + R R + + +A+ A +RS ++ PL +A+ R+ +DWL G Sbjct: 122 NLARYGKWTKPTR----RLWMQSMTDEAILNAWHGMRSEADMKPLTNAAVCRSESDWLVG 177 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 +N TRA TIL G+ V GRVQTP L ++ +R+ EI+ F + + EV A + Sbjct: 178 LNSTRALTILQSRGGFN-VTPAGRVQTPTLAILTQRELEIQAFEPEPYSEVWAEFDVQSG 236 Query: 234 ERFTAIW---QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 ++ W + P+ E R+ A + +R G+ VT K + APL Sbjct: 237 S-YSGRWIDRDWKKNDHPHSRAE-RIWDPEQAAVIRDRCRGKAGTVTE-EKKPVTTVAPL 293 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 + L++LQ EAA R+G SA+ L + Q+ YE HK++TYPR+D RYLPE++ + ++ Sbjct: 294 LYDLTSLQREAANRYGFSAKRTLQLAQECYEKHKVLTYPRTDSRYLPEDYLGKVYGIVGT 353 Query: 351 ISVHAP-------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVY 403 ++ P D+L + P+ R +D KKV H AIIPT + LT + K++ Sbjct: 354 VAEQNPEFAPFARDILDNKRIKPN--RRVFDTKKVSDHFAIIPTGKME--KLTGDAQKLF 409 Query: 404 NLIARQYLMQFCPDAVFRKC-----VIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 ++ ++L F P AVF + D F+ R L E GW+ + G K Sbjct: 410 EMVMARFLAVFFPAAVFEDTRRTTLITHQDGVTDAFLTTGRVLVEPGWQAVYGRKAGTSS 469 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + L V G++ + E+ T+PP + +ATLL+AM G + V D++L + + Sbjct: 470 KE--ELVPVRDGEQAALREIEIRNAMTKPPARYNEATLLAAMEGAGKLVHDEELAAAM-S 526 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA----TRPDMTAHW 574 GLGT ATRA IIE L + ++ + GR + +T G L L + T P +T W Sbjct: 527 ERGLGTPATRASIIEGLISQEYIVRDGRELLATRRGIELIALLERIGLKTLTSPSLTGEW 586 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 E L Q+ + FM+ + +++ + K Sbjct: 587 EYKLKQMEQAALPRDSFMEGIKTLTGEIVKRVK 619 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 284 bits (727), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 189/634 (29%), Positives = 315/634 (49%), Gaps = 30/634 (4%) Query: 3 LFIAEKPSLARAIADVL-PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L IAEKPS+A + VL K +K + E + +V+ IGHL+ A P D RY W Sbjct: 35 LIIAEKPSVAADLVKVLGAKSFKKETAYYES-DTTIVSHAIGHLVGIADPKDIDERYKAW 93 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 ++ LP++PEK+ L P+ L+ + + + + + I++A D REG+L+ ++DY+ Sbjct: 94 DMKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELIFYYIVDYI 153 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 K + +R + + P A++ A + LR+ + V L +AL R+ ADWL G+N +R Sbjct: 154 LKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWLVGMNGSRG 213 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T + G + GRVQTP L ++V+R+EE F+ + F+ ++A A + Sbjct: 214 LTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWTIEASF-DNAGAGYQGK 272 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + E +D ++ A+ ++ + G+ + + + L + L+ LQ Sbjct: 273 WFTVDK-ENGKDRVKQIFDEARAQEILAKCKGKTGSIEETTAPSQQKCGQL-YDLTTLQR 330 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA RFG SA+ L I Q LYE +K TYPR+D R LPE++ A A + I Sbjct: 331 EANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVKATLGKIEGPLAK-F 389 Query: 360 PQPVVDPDIRNRC---WDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCP 416 Q +D + R +D+ K+ H AIIPT L+E E K+Y +I ++++ F P Sbjct: 390 AQEALDKNYVKRTPKVFDNSKISDHFAIIPTGVVPK-GLSEAEEKIYTMICQRFIAVFFP 448 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 A + + F+ + + L + G++ + G KE DEE++ +P + G+ Sbjct: 449 PAQYLNTTRITTVENETFITEGKILVDPGFKAIYG-KESDEESN---IPKL-NGNTAKTL 503 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 E E T+PP H+T++TLLS M + V+D +L+ ++ GLGT ATRA IIE L Sbjct: 504 AIESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKER-GLGTPATRAAIIEKLV 562 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMA----TRPDMTAHWESVLTQISEKQCRYQDFM 592 ++ + G+ + T L L M T P++T WE + IS+ + + FM Sbjct: 563 SDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEYKMDLISKGKESREAFM 622 Query: 593 QPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 ++ + +T V+ +G + G A Sbjct: 623 NGII--------EMTKTMVKNIKGFKEESTTGEA 648 >UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID=TOP3_STAEQ Length = 711 Score = 284 bits (727), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 191/617 (30%), Positives = 306/617 (49%), Gaps = 44/617 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+ R IA+ L +K +G+IE G +VTW +GHL+ A P+ Y+ Y WN Sbjct: 4 LILAEKPSVGRDIANAL-NLQQKSNGYIE-GKQYIVTWALGHLVTNATPEQYNPSYKEWN 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLPI+P+K + +Q ++K + EI+ A D REG+L+ +LD + Sbjct: 62 LEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILDKVG 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ ++R I+ + +A++ +L++ + + L +ALAR+ ADW+ GIN TRA Sbjct: 122 ----NKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINATRAL 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T Y LS+GRVQTP + +V R +EI F + ++ + ++ D + Sbjct: 178 T-----TKYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINV----DGYDLNLK 228 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q Y+D++ L EH + G+ V N K S + PL F+L+ LQ E Sbjct: 229 QQKR----YKDKK----ELELIEHKIKHQEGKILEVKGKNKK--SYAQPL-FNLTDLQQE 277 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-----SVHA 355 A K + + + L+ Q LYE HKL+TYPR+D YL ++ + AI H Sbjct: 278 AYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATDYKSHV 337 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQF 414 DL+ + + ++++KV HHAIIPT R S L++ E K+Y LIA ++L Sbjct: 338 RDLISESFSS---KMHIFNNQKVSDHHAIIPTEVRPSIEQLSQREFKIYMLIAERFLENL 394 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 ++ I + FV K + G++ L +D+ + T +G Sbjct: 395 MNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKAL-----KDQTSSHTLTHSFKEGQLFK 449 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFV--QDKDLKKILRATDGLGTEATRAGII 532 + E+ E +T+ P +F + +LL AM + DK K L+ + G+GT ATRA II Sbjct: 450 VHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRADII 509 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E LF L + I T GK + P T P +TA WE L I + + Q F+ Sbjct: 510 EKLFNMNALESRDGKIKVTSKGKQILELSPSELTSPILTAQWEEKLMLIEKGKYNSQKFI 569 Query: 593 QPLVGTLYQLIDQAKRT 609 Q + ++++++ K + Sbjct: 570 QEMKNFTFKVVNKIKSS 586 >UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamiensis G4 RepID=A4JW73_BURVG Length = 823 Score = 282 bits (721), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 204/626 (32%), Positives = 309/626 (49%), Gaps = 48/626 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+A IA L K DG+ E + +V GHL+EQ P A D++ W Sbjct: 5 LIVAEKPSVAADIAKALGG-FTKADGYFERDDA-IVAPARGHLVEQTVP-AADAK-GMWK 60 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P+ ++L+ T + + +K+ + + + +V+A D REG+L+ + + Sbjct: 61 IGVLPIIPDSFELEVIDGCTAEFSRLKKLMARDDVASVVNACDAGREGELIFRLIYNKAG 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ +R I + A+ +A D LR +EF L +A R+ ADW+ G+N TRA Sbjct: 121 C----RKPTKRMWIQSMVASAIRKAHDDLRPGAEFDHLSDAAFCRSEADWIVGVNGTRAT 176 Query: 181 TIL-GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L R + V VGRVQTP L + V R+ EI FVA+D++E+ A + A Sbjct: 177 TALRERKTQRREVSPVGRVQTPTLAMPVIREREIAAFVARDYWEIHGTFRAEAGT-YVAK 235 Query: 240 W--------QPSEA---CEPYQDEEG-RLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 W P+E E ++ G R + A+ +V++ G K E Sbjct: 236 WIGDADGDTSPAETEGDAEAEAEQTGARCFDKAKAQAIVDKCKGVDPSSVVDESKPEERP 295 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 AP F L+ALQ EA KRF SA+ LDI Q LYE HK TYPR+D R LPE++ A Sbjct: 296 APALFDLTALQREANKRFKFSAKKTLDIAQALYEKHKATTYPRTDSRALPEDYLETAAAT 355 Query: 348 MNA-----ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 + + HA ++ V PD R +++ + H AI+PT + L+ +E K+ Sbjct: 356 LATFASTPLEAHAQRVIENGWVKPD--KRIFNNADISDHFAIVPTGQQPD-GLSSDEQKI 412 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 Y+L++R+++ F P A + K V +A F + L E GW + G K D + Sbjct: 413 YDLVSRRFIAVFHPSAKYEKTVRTTIVAGETFRTSGKVLVEPGWLAVYGEKAHD--DTAA 470 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 L VA G+ + + E+ QT+PP+ +T+ATLL+AM R V+DKD++ ++A +G+ Sbjct: 471 ALCKVADGEAVTADAIELKALQTKPPKRYTEATLLAAMENAGRQVEDKDIRAAMKA-NGI 529 Query: 523 GTEATRAGIIELLF---------KRGFLTKKGRYIHSTDAGKALFHSLPEMA----TRPD 569 G ATRA IIE L K +L + + T L L E P Sbjct: 530 GRPATRAAIIEGLLEDKDKNDNPKEPYLRRDDNELVPTPKAMELIAFLEEAGIDFLVSPQ 589 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPL 595 MT WE L ++ + R FM + Sbjct: 590 MTGEWEQKLLRMEKGDYRRSTFMSEI 615 >UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9Z3_9FIRM Length = 707 Score = 281 bits (720), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 204/632 (32%), Positives = 314/632 (49%), Gaps = 69/632 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 +L IAEKPS+AR+IA V+ ++ +G+ + G G +V+WCIGHL+ A+ YD +Y + Sbjct: 3 FQLVIAEKPSVARSIAAVIGATEKQ-NGYWQ-GGGYLVSWCIGHLVSFAEAGQYDEKYCK 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ WQ +Q +++ L+ + + A D REG+L+ V Sbjct: 61 WRYEDLPILPQPWQFIVPDEKKQQFEIVRSLLNRPDVDSVTAATDAGREGELIFRFVY-- 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 Q+A + V+R I+ + A+ LR +S++ L SAL RA+ADWL GIN TR Sbjct: 119 -QMAGCTKP-VKRLWISSMEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATR 176 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV--KAHIVTPADERF 236 +++L Y L+VGRVQTP L ++V RD +I F + ++ V ++ + ER Sbjct: 177 LFSVL-----YHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQSGSLKADSERI 231 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 + D E A + + +G A+ S ++++E P + L+ Sbjct: 232 S-------------DAEA-------ANLLKEKCTGANAVCVSIRREKKTEQPPKLYDLTT 271 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF-AGRHAVMNAISVHA 355 LQ EA + FG +A+ LD Q+LYE KL+TYPR+D +YL E+ +H V + + Sbjct: 272 LQREANRLFGFTAKQTLDYAQQLYE-KKLLTYPRTDSQYLTEDMGRTAQHLVSDLLG--- 327 Query: 356 PDLLP--QPVVDPDIRNRCWDDKKVDAHHAIIPTA---RSSAINLTENEAKVYNLIARQY 410 LLP Q + R + KKV HHAIIPT+ + L E+E K+ NL+ + Sbjct: 328 --LLPFAQGLALTAEVGRVLNSKKVSDHHAIIPTSEFVKQGFTGLAESECKLMNLVCSKL 385 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGW-------RTLLGSKERDEENDGTP 463 L + A +F AK + + GW R+ L + +E Sbjct: 386 LCAVAAPHEYETVTAVFSCAGNEFAAKGKTVLVPGWKEIDQRFRSTLKTDGEEETETLNT 445 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM--TGIARFVQDK----------D 511 LP + +G ++ E T PP+ +T+ TLLSAM G +DK Sbjct: 446 LPELTEGQNFSVTT-DISEHFTSPPKAYTEDTLLSAMERAGAEDMPEDKVNCSAGAREGG 504 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMT 571 L + R GLGT ATRA I+E L + GF+ +KG+ + T G L LPE T P +T Sbjct: 505 LGQAER--KGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPVLT 562 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 A WE+ LT+I++ +FM + + QL+ Sbjct: 563 AEWENRLTEIAKGNADPDEFMAEIEAQVRQLV 594 >UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_SORC5 Length = 1476 Score = 280 bits (715), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 222/731 (30%), Positives = 332/731 (45%), Gaps = 106/731 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKP++AR IA VL ++ +GF+E G G VVTW IGHL+ A+P D + R Sbjct: 1 MIAVVAEKPAVARDIAAVL-GASKRAEGFLE-GGGYVVTWAIGHLVAIAEPHQIDPAWKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W L LP++P ++ L P Q ++++ L + +V A D REG+L + Y Sbjct: 59 WRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGEL----IFRY 114 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + A ++ V+R I+ L P A+ + RLR + L +A R+RADWL G+N++R Sbjct: 115 IYEAAGCKKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV-------TP 231 AY+++ + LSVGRVQTP L +VV R+ I FV + + EV A Sbjct: 175 AYSLV-----FDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGA 229 Query: 232 ADERFTAIW---------------QPSEACEPYQDEEGRLLHRPLAEHVVN---RISGQP 273 ADE + + +P+ P E RP A N R P Sbjct: 230 ADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAP 289 Query: 274 -----------------------AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQ 310 A + + + PL + L+ LQ A + +G SAQ Sbjct: 290 SRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQ 349 Query: 311 NVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRN 370 L++ Q LYE KLI+YPR+D R+L E A A + AI +L + Sbjct: 350 KTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGK 409 Query: 371 RCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRK------- 422 R DD KV HHAIIPT ARSS L+ +E K+++LI R+ L + D V Sbjct: 410 RFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAI 469 Query: 423 ----------------------CVIE------LDIAKGKFVAKARFLAEAGWRTLLGSKE 454 V+E LDI GK A+ R E+ Sbjct: 470 TTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDA 529 Query: 455 RDEEN--------DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 RD E D P +A+G L E ++T+PP FT+ATLL+AM Sbjct: 530 RDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSS 589 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT 566 +++K+L ++ + GLGT ATRA IIE L +R ++ +KG+ +H+TD G L + Sbjct: 590 LEEKELSAAMKDS-GLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVK 648 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 P MT WE+ L +++ FM + + Q++ + G ++P +G S Sbjct: 649 SPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASP 708 Query: 627 DKKKAAPRKRS 637 +++ R R+ Sbjct: 709 FQERGEARSRA 719 >UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_9DELT Length = 1409 Score = 279 bits (713), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 203/629 (32%), Positives = 324/629 (51%), Gaps = 50/629 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + +AEKPS+AR IA L R+ G++E G G VTW +GHL+ A+P D+ + W+ Sbjct: 4 VVVAEKPSVARDIAAALGATQRR-KGYLE-GEGYRVTWAVGHLVGLAEPGDIDAAWKYWD 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDYLQ 120 LA LP++P W L+ QL V+ R ++ E+V A D REG+L+ + Y Q Sbjct: 62 LATLPMLPRSWPLRALEHGADQLAVLARLMNARGVKELVSATDAGREGELIFRYI--YEQ 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + K +R I+ L +A+ RLRS ++ L +A AR+RADWL G+N++RAY Sbjct: 120 VGCTK--PWRRLWISALTHEAIRAGFRRLRSPAQLEGLANAARARSRADWLVGMNLSRAY 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++ + LSVGRVQTP L ++V R+ I FV + + EV A E + ++ Sbjct: 178 SLR-----HDDSLSVGRVQTPTLAMLVERERAIREFVPELYREVHARFGASVGE-YEGVY 231 Query: 241 ----------QPSEACEPYQDEEG------RLLHRP-LAEHVVNRISGQPAIVTSYNDKR 283 Q A +P +D + RL P AE V+ R A V S + + Sbjct: 232 HRPAPPDSETQAQRAAKPRRDAKAAANTLARLPAEPDEAEEVIARAKRGEAHVASVSRTK 291 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 S PL + L+ LQ A + FG SA+ LDI Q LYE HK ++YPR+D R++ E Sbjct: 292 RSFPPPLLYDLTELQRHANRLFGFSAKRTLDIAQTLYERHKALSYPRTDSRHIDRETAGT 351 Query: 344 RHAVMNAI----SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENE 399 +++ AI S +L+ + + + +R +D KV HHAI+PTA ++ +E Sbjct: 352 LGSIVAAIAPSYSGAETNLVAERSGERPLGSRYVNDAKVSDHHAILPTAERPSLRAGSDE 411 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG-----------KFVAKARFLAEAGWRT 448 AK+Y+L+ R+ L + + + +E I ++++ + + GW+ Sbjct: 412 AKIYDLVCRRLLAAYHEPHIEARTKVETHIVTARPEAGVEAIVDRYLSTGSSVEQEGWK- 470 Query: 449 LLGSKERDEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 +L + R + LP +AK + + +QTQPPR ++ATLL AM R + Sbjct: 471 VLDLRVRPKAKTEPKLPGGLAKDQAVRVLDVRALSKQTQPPRPHSEATLLGAMEHAGRQL 530 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKG-RYIHSTDAGKALFHSLPEMAT 566 D+ L + +R + GLGT ATRA IELL +RG++ ++G + + ++ G+ L ++ Sbjct: 531 DDEQLGEAMRGS-GLGTPATRAATIELLLRRGYVEREGSKALRASPKGERLIDAVHPQVK 589 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPL 595 P+MT +WE L Q+ + + FMQ + Sbjct: 590 SPEMTGNWELSLHQMRGEAGELEAFMQTI 618 >UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GFF6_9FIRM Length = 1317 Score = 278 bits (712), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 189/628 (30%), Positives = 318/628 (50%), Gaps = 42/628 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A +L R DG+IE + V+TWC+GHL+E P+ YD +Y RW Sbjct: 5 LIITEKPSVAQEFARILGVSGRN-DGYIE-NDKYVITWCVGHLVEMVYPEEYDEKYKRWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL-HEASEIVH-AGDPDREGQLLVDEVLDYLQ 120 L DLP +PE+++ P V+KQ + + R L E E V+ AGD +EGQ + + + + Sbjct: 63 LEDLPFLPEEYKYNVIPDVSKQYDTVHRMLFREDIETVYWAGDAGKEGQTIEENIRRFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + P ++ R I+ + + R I + +E+ L S + R D+ GIN +RA Sbjct: 123 VRPGMKE--LRVWIDSQTEEEILRGIREAKPMAEYDNLAKSGIMRTIEDYAMGINFSRAM 180 Query: 181 TI-----LGRNAGYQG--VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV---T 230 ++ L A + ++VGRV T VLG+VV R+ EI NF F+ V + Sbjct: 181 SVKYGKLLNDAAATKSYTAIAVGRVMTCVLGMVVIREREIRNFAETPFYRVVGGFLPEGA 240 Query: 231 PADERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 +E TA W+ + ++ +E R AE+++ + G+ A+V S + Sbjct: 241 ETEETVTAEWKAVNGSKYFESPLLYKENGFKKRESAENLIGELDGKQAVVKSLERGTSRK 300 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 APL F+L+ LQ E +KR+ +S L + Q LYE KL TYPR+D R L Sbjct: 301 KAPLLFNLAELQAECSKRYKISPDETLQVAQDLYE-KKLTTYPRTDARVLSTAVAKEIGK 359 Query: 347 VMNAISVHAPD------LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENE 399 +N + + P +L + R + DD K+ H+AIIPT + + + +L++ + Sbjct: 360 NLNRLKTYEPTKTYTERILKEGTYRNIARTQYTDDSKITDHYAIIPTGQLTELGSLSDLQ 419 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL---GSKERD 456 +VY+L+ R++L F P A + + + + + A A+ L G+ ++ G+ E Sbjct: 420 RRVYDLVVRRFLSIFYPAAEYETIKLVVQVGAEQLFASAKVLKNPGFLEIMGRPGNDENK 479 Query: 457 EENDGTPLPVVAK---GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 EE L + + GD L + E+ E +T PP+ +T +++ AM + +++++L+ Sbjct: 480 EEESAGLLKLAGQLKTGDPLKVDGYEIKEGKTAPPKRYTSGSMVLAMENAGQLIEEEELR 539 Query: 514 KILRATDGLGTEATRAGIIELLFKRGF--LTKKGRYIHSTDAGKALFH----SLPEMATR 567 + ++ + G+GT ATRA II L + G+ L +K + + G+ +F ++P + Sbjct: 540 EQIKGS-GIGTSATRAEIIRKLVRIGYLNLNQKTQVLSPEAIGEMVFEVVSMTVPALLN- 597 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPL 595 P MTA WE L I+ +D+ L Sbjct: 598 PKMTASWEKGLDGITRGTVIMEDYRSKL 625 >UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y9I3_COPPD Length = 685 Score = 277 bits (708), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 196/597 (32%), Positives = 306/597 (51%), Gaps = 43/597 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + EKPS+AR IA L KP ++G+ + G V+ +GHLL+ A P+ Y RY +W Sbjct: 4 LIVTEKPSVARQIAAALGKPKKEGNHLV-VGE-YVIAHAMGHLLQFAYPEHYGERYKKWR 61 Query: 63 LADLPIVP--EKWQLQP-RPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 L DLPI+P ++WQL P + KQL IK +A ++ A D REG+L+ + Y+ Sbjct: 62 LEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQYV 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + ++R + L + + I +L SE L SALARA+ADWL GIN +RA Sbjct: 122 GI----EKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T++ + V S+GRVQTP L ++V R++EI++FV + +++VK + Sbjct: 178 FTVVSKKE----VFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEGK----SF 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W +E+ + Y + AE + + G+ IVT +++ + PL L LQ Sbjct: 230 W--AESVKEY--------DQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQK 279 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 ++ F SAQ L I QKLYE + LITYPR+D RYLP + N + Sbjct: 280 FTSRSFKWSAQKTLKILQKLYE-NALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKGN 338 Query: 360 PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAV 419 + V + R R +++ +V H AIIPT + L ++ K++N + ++L F P A+ Sbjct: 339 WEYVKKLNNRGRIFNNARVTDHFAIIPTGKIK--ELKGDDEKMFNYVVDRFLAAFYPPAL 396 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGE 479 F A + + W T+LG KE E LP +A E++ + Sbjct: 397 ETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQE-----LLPKIA---EVMVLETS 448 Query: 480 VVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRG 539 +RQT+P FTD L++AM + V+ ++L +IL+ G+GT ATRA IIE L + G Sbjct: 449 AEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKE-KGIGTPATRAEIIERLIEMG 507 Query: 540 FLTKKGRYIHSTDAGKALFHSLPEMA----TRPDMTAHWESVLTQISEKQCRYQDFM 592 ++ + G + T G L +L E+ T P++T WE L I + + + FM Sbjct: 508 YVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFM 564 >UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ2_FIBSS Length = 1049 Score = 275 bits (703), Expect = 4e-72, Method: Compositional matrix adjust. Identities = 208/671 (30%), Positives = 338/671 (50%), Gaps = 78/671 (11%) Query: 1 MRLFIAEKPSLAR-----AIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 M L +AEKPS+A + + + +GDG + G +TWC+GHL+ A DAY Sbjct: 1 MILLVAEKPSVANQHYKPMLERIEGEKFTQGDGCL-IGKNHCITWCVGHLITLAPLDAYP 59 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L++LP++PEK++L S KQL V++ + A +V+ D REG L+ D + Sbjct: 60 GFEGGWRLSNLPLLPEKFKLMEIESTRKQLGVVRDMMARADVLVNGADAGREGNLIFDLI 119 Query: 116 LDYLQLAPE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 LDY P+ +++Q++R +N + +++A L +E + L +A R RADW+ G+ Sbjct: 120 LDY---TPDFRKKQIKRLWVNSYVAKDLDKAWKNLEDATERLNLSYAARLRQRADWMVGL 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV-------KAH 227 N TRAYT+ AG ++SVGRVQTP L LVV RD +E F ++ V +A Sbjct: 177 NATRAYTL---TAGRGKMISVGRVQTPTLNLVVERDAIVEQFKELFYYSVVGTWKGFQAQ 233 Query: 228 IV------------TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPA 274 +V TP DE+ A Q + ++ EE A+ V+++ S + A Sbjct: 234 LVKSETKEEKGDSGTPVDEKVAADKQSNLKVAIFEKEEP-------AQAVIDKCSPPEEA 286 Query: 275 IVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCR 334 + + +++ + PF L+ LQ E KRF SAQ VLD Q LYE KL+TYPR+D + Sbjct: 287 AIAKVDIQQKKQFPQKPFDLTELQKEGNKRFKYSAQQVLDCAQNLYE-KKLLTYPRTDSQ 345 Query: 335 YLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCW-DDKKVDAHHAIIPTARSSAI 393 YLP+ +A+ A + +P + V+ N + + KV H AIIPT Sbjct: 346 YLPDTMQQEAYAL--AQRLASPQ--EKSVMRDGNENFVFINSSKVTDHFAIIPTGEEPQ- 400 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLL-- 450 NL E E +Y L +++ + V+ + + LD A + F K + + G+R L+ Sbjct: 401 NLPEMEENIYKLAKERFVQAWLKPYVWSEMEVLLDAANAEIFRLKLKRNEDLGFRALVKE 460 Query: 451 -------------GSKERDE-------ENDGTPLPVVAK-------GDELLCEKGEVVER 483 GS+ D + DG + + + GD + E+ ++ Sbjct: 461 EKKKPSKKKKGDAGSESGDAKGADSEGKGDGDDITNIVETFPEWNLGDHAPFDSLELQKK 520 Query: 484 QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTK 543 + P++FT+ATLL+AM + +++++L + ++ GLGT AT+AGIIE L KRGF+ Sbjct: 521 KKSKPKYFTEATLLAAMKTAGKQIENEELAEAMKER-GLGTPATQAGIIETLKKRGFIEA 579 Query: 544 KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 + Y+ ST G+ + + E P+MT WE L+Q+ + + +F +V + +L Sbjct: 580 QKNYLVSTQRGREVIELMDEKVKSPEMTGEWEFKLSQVEKGKLTPIEFRDGIVNYVKELF 639 Query: 604 DQAKRTPVRQF 614 + ++ QF Sbjct: 640 EHLRQKYGSQF 650 >UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D1W4E5_9BACT Length = 714 Score = 274 bits (700), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 197/608 (32%), Positives = 299/608 (49%), Gaps = 46/608 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-YA 59 M+ IAEKPS+AR IA ++ R+ +G+ E G G VTW GHL++ A PD Y R + Sbjct: 20 MKTIIAEKPSVAREIARIVGATKRE-EGYFE-GGGYAVTWAFGHLVQLAMPDGYGVRGFV 77 Query: 60 RWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREG 108 R NL PI+P+ + L PR V Q+ VIKR + I+ A D REG Sbjct: 78 RDNL---PIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDTSEHIIVATDAGREG 134 Query: 109 QLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA 168 +L+ + Y R I+ L +A+ + +L S++ L ++A AR+ + Sbjct: 135 ELIFRYLYHYTGCTT----PFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKARSES 190 Query: 169 DWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 DWL GIN T+A +I A G SVGRVQTP L +V R E F ++ F+ + HI Sbjct: 191 DWLVGINGTQALSI----AAGHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLL--HI 244 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 T + + SE ++++E P E + A VT K ++E Sbjct: 245 ATDGCDGEVVKFSSSE---KWKEKE------PAMELYNKVKAAGCATVTKAERKEKTEET 295 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA + G +A+ L+I QKLYE KLITYPR+ RY+PE+ FA ++ Sbjct: 296 PLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYE-KKLITYPRTGSRYIPEDVFAEIPKLL 354 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 I P+ + R DD KV HHA++ T + L++ + +Y +IA Sbjct: 355 AFIGTQ-PEWKDKVRAKAAPTRRSVDDGKVTDHHALLVTGE-KPLFLSKEDNTIYQMIAG 412 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + F V + + A +F K + + GWR + G EE + +P Sbjct: 413 RMVEAFSEKCVKDVTTVTAECAGVEFTVKGSVVKQTGWRAVYG-----EEKEEITIPGWQ 467 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GD L + + E +T+P T+ATLLSAM + ++D L++ ++ G+GT ATR Sbjct: 468 EGDTLTPKGSSITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATR 526 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQCR 587 A IIE LFKRG++ + + + T+ G AL + M MT WE L +I + Sbjct: 527 ASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWEKELARIERGELS 586 Query: 588 YQDFMQPL 595 F + + Sbjct: 587 ADTFRKEI 594 >UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotuberculosis IP 31758 RepID=A7FCC2_YERP3 Length = 815 Score = 273 bits (698), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 196/655 (29%), Positives = 324/655 (49%), Gaps = 54/655 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLE--QAQPDAYDSRYAR 60 L IAEKPS+A IA L +K D F E + +++ IGHL+E + DA ++ Sbjct: 6 LIIAEKPSVAFDIAKALGGFQKK-DNFFE-SDRIIISNGIGHLVEVYSTEMDAEGTK--- 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 +L+ LP++P +Q++P+P Q N++K+ ++ + +++A D REG+L+ + + Sbjct: 61 -DLSALPVIPSHFQVKPKPKTISQFNLLKKLMNRPDVGSVINACDAGREGELIFRLIYE- 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 A R+ ++R I + P A+ A + ++ + + +A R D++ GIN +R Sbjct: 119 ---AIGSRKPMKRMWIKSMTPTAIREAYENIKDGRFYDRVDDAARCRTEGDFIVGINASR 175 Query: 179 AYTIL-GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 A T R +L+ GRVQTPVL ++ +R++EI +FV + F+EV A T A + Sbjct: 176 AITAFKSRQERSFQMLAAGRVQTPVLSMITQREDEIRSFVQRTFWEVMA-TFTLASGEYN 234 Query: 238 AIWQPSEACEPYQDEEG-RLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLS 295 W P+++ Q+ +G R + A+ ++++ G +P VT + +S P F+ + Sbjct: 235 GRWIPAKSTNSNQESDGSRFFDQSAAKAILDKCRGVEPTSVTEVSKITKSH-PPKLFNQT 293 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV-- 353 ALQIEA KR+ SA+ LD+ Q LYE HK+++YPR+ LPE++ ++M + Sbjct: 294 ALQIEANKRYKFSAKKTLDLTQALYEKHKMVSYPRTSSTALPEDYGDTVLSIMTHLFTGS 353 Query: 354 ----HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIA 407 +A + +DP + +D+ ++ H AIIP ++ + LT +E K+Y+LI Sbjct: 354 EYEKYAAYVTTHNRIDPSNKT-IFDNDEISDHFAIIPAIGSQCNVAGLTPDELKIYDLIV 412 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 R+++ F P A + +A+ F R L E GW+ ++ ++ +N L + Sbjct: 413 RRFIAAFYPVATYSATERLTIVAEESFKTTGRVLLETGWQAVI---KQPTDNATNSLCAL 469 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G+ + + T PP F ATLL+AM + V D DL K ++ GLGT+AT Sbjct: 470 KEGETAGNKVMGLKTGNTTPPSRFNVATLLAAMQTAGKLVDDDDLAKAMKGC-GLGTDAT 528 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGK-ALFHSLPE--------------MATRPDMTA 572 RAGIIE L + + GK LF P+ M T P MT Sbjct: 529 RAGIIEGLLSNKTAAGNAKEPYIVIEGKEQLFVPTPKAMDLISFLRDNNVLMLTNPTMTG 588 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK-------RTPVRQFRGIVAP 620 WE L+ + + Q FM + Q+ID K P R F G P Sbjct: 589 EWEQKLSLMEHGKYNRQTFMAEIAENTRQMIDTIKVRASEIPAEPHRDFAGAKCP 643 >UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID=B2RGV8_PORG3 Length = 709 Score = 272 bits (696), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 200/636 (31%), Positives = 327/636 (51%), Gaps = 65/636 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA V+ ++K +G+IE G G VTW +GHL+ A P+ Y + Sbjct: 1 MKVIIAEKPSVAREIARVVRATNKK-NGYIE-GGGYAVTWALGHLITAAMPEVYGIK--G 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 ++ +LPI+P + L PR PS QL VI++ A I+ A D REG+ Sbjct: 57 FHKENLPILPPVFTLIPRQVRSGKGYKADPSAVAQLKVIEKLFKAAEGIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL +A + +R I+ L +A++ + RL++ + + L +A AR+ AD Sbjct: 117 LVFRFIYEYLGIA----KPFERLWISSLTDKAIKEGLARLQNGAAYDNLYYAARARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A +I A +G S+GRVQTP L +V R E + F + F+++ + V Sbjct: 173 WLVGINATQAISI----AAGRGTYSLGRVQTPTLCMVCSRFLEHKKFEPQPFWQL-SLAV 227 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 DE F + S A + E L+ L + A V + K + P Sbjct: 228 KEGDESF----RFSSADRWFDKTEATALYDKLKQ-------APYATVETIVRKEARQEPP 276 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ EA RFG SA+ L + Q+LYE ITYPR+ RY+PE+ FA A++ Sbjct: 277 LLYDLTTLQKEANSRFGYSAEQTLSLAQRLYE-KAYITYPRTGSRYVPEDVFAEIPAMIA 335 Query: 350 AI------SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVY 403 + VHA L ++ D KKV HHA++ T + I++ +EA +Y Sbjct: 336 FLHDHPVWGVHARRL-------TELNAHSVDGKKVTDHHALLITGKKP-IDVFGDEAVIY 387 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEE---- 458 ++IA + L F V + + KF+ K + E GWR++L S+++D+E Sbjct: 388 DMIAGRMLEAFSARCVKDISTVTAVCEEVKFILKGEIIKEEGWRSILKNSRKKDKEQAEA 447 Query: 459 --------NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDK 510 +G +P +G +L + + T+P T+++LL+AM + ++D+ Sbjct: 448 EERESRENGEGIIIPQWEEGGQLPLCACSLAQGTTKPKPLHTESSLLAAMETAGKELEDE 507 Query: 511 DLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT-RPD 569 +L+ + G+GT ATRA IIE LF R ++ ++ + + T+ G A++ + EM + Sbjct: 508 ELRAQFKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVREMKIGNAE 566 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 MT WE+ L +I + + +DF + + Q+ D+ Sbjct: 567 MTGQWEADLAKIERGELKERDFRKGIESYATQITDE 602 >UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacterium spiritivorum ATCC 33861 RepID=C5PM09_9SPHI Length = 704 Score = 272 bits (695), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 186/620 (30%), Positives = 317/620 (51%), Gaps = 53/620 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR +A V+ DG+I GNG T+ GHL++ P AY + Sbjct: 1 MKVVIAEKPSVARDLARVMG-AKEVNDGYI-SGNGYAFTYAFGHLVQLCTPQAYG--FHT 56 Query: 61 WNLADLPIVPEKWQLQPRP-----------SVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 W++++LPI+P +++L+ + KQLN IK L +A E++ A D REG+ Sbjct: 57 WSVSNLPIIPAQFKLESKKVKKDGKQMDDGGALKQLNTIKGLLDKAEEVIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL +R I+ +A++ L+ SE+ L +SA +R+ +D Sbjct: 117 LIFRNIYYYLG----ANVPFKRLWISSQTDKAIKEGFANLKEGSEYDSLYMSARSRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ AG +G+LS+GRVQTP L ++ R E +NF F++++A Sbjct: 173 WLIGINATQAITLA---AGNRGLLSLGRVQTPTLAMICSRFIENKNFKPTAFYKIQAQF- 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESA 288 + +F A R+ + LAE + +I+ G A VT K E Sbjct: 229 EKENIKFKAT-------------SNRIDQKDLAEETLAKITVGASAKVTKVEGKEVKEPP 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ +A K++G SA L I Q LYE K+ITYPR+ RY+ E+ F + Sbjct: 276 PLLYDLTNLQQDANKKYGYSADQTLSIAQTLYE-KKVITYPRTGSRYIGEDVFEKIEELF 334 Query: 349 NAISVHAPD---LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 ++ A + + + ++ + R DDKKV HHA++ T + L E ++ +YN+ Sbjct: 335 QHLADTAEEGIATISRNLIGAKLNKRSVDDKKVTDHHALLVTDEKPSAMLKE-QSNIYNM 393 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE-------- 457 IA++ + F + + +D + +AK + + GWR E+ E Sbjct: 394 IAKRMVESFSDVCLKDITTVIMDAEGVELIAKGTVIKQYGWRLSADQLEQPEDDKKDNDD 453 Query: 458 -ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 + + LP ++ + L +++E+ T+ T+A+LL AM + + D ++++ + Sbjct: 454 ADTENAQLPKLSAEELLEILALDLMEKFTKAKPVHTEASLLKAMETSGKEIDDDEMRQAM 513 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDMTAHWE 575 + GLGT ATRA IE LF+R ++ + + + TD G A+++ + + A + ++T WE Sbjct: 514 KDC-GLGTPATRAATIETLFQRDYIRRDKKKLIPTDKGLAVYNLVKDRAIAKVELTGKWE 572 Query: 576 SVLTQISEKQCRYQDFMQPL 595 L ++ + Y FM+ + Sbjct: 573 QKLEEMRANKVSYDVFMKHI 592 >UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYW8_9BACL Length = 702 Score = 271 bits (694), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 178/597 (29%), Positives = 306/597 (51%), Gaps = 40/597 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + + EKPS+AR IA L + K +G +E G+ VVTW +GHL+ PD Y + + Sbjct: 4 VVLCEKPSVARDIARNLGAKNNK-NGCLE-GDKYVVTWALGHLITLQTPDKY-KEFNNVS 60 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +LP++P+ + + KQ V++ L+ + +E++ A D REG+L+ ++D + Sbjct: 61 LENLPMIPKFMKTEIIKKTFKQYKVVENALNRKDVNEVIIATDAGREGELVARYIIDKAK 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R I+ + +A++ L+ E++ L S +ARA ADWL GIN +RA Sbjct: 121 C----NKNVKRLWISSVTDKAIKDGFRNLKDGKEYLGLYHSGIARANADWLVGINASRAL 176 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ Y L+ GRVQTP L +V R+E+I+ F KD++ +A I +F Sbjct: 177 TL-----KYNASLNCGRVQTPTLQMVFEREEKIKQFKPKDYYTFEAQI---DGVKF---- 224 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 +C + + AE + + + K ++ S ++L+ +Q Sbjct: 225 ----SCGNSE------FNLEKAEQFIKKNINKEIKFNDVQKKAKTSSVKPLYNLTDIQQT 274 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+ FG+S + L+I Q LYE HK++TYPR+D RYL + + AI + + Sbjct: 275 ASALFGMSPKQTLNIVQSLYERHKVLTYPRTDSRYLTSDMKNTLKDRIQAIGGDFKETIA 334 Query: 361 QPVVDPDIRNR-CWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCPDA 418 + + D + ++ KV HHAIIPT + + +++++ E K+YNL+A+++L P+ Sbjct: 335 KLLKVKDYNTKKIINNAKVSDHHAIIPTEQKPNYMSMSDMETKIYNLVAKRFLENLLPEY 394 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + + +I F AK + + G++ L R+E D T + + + E Sbjct: 395 KYEETTYSFNIENKVFSAKGLKVIQEGYKEL----SREELQDKT---INLQNNNHKLESL 447 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 ++QT PP ++T+ TL+ AM FV D++ +KIL+ T+G+GT ATRA I+E LF Sbjct: 448 VYNKKQTTPPSYYTEGTLIYAMENPFEFVDDENERKILKETNGIGTVATRADILEKLFTN 507 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +L I +T+ K L + +P+ P +TA WE L I++ + F+ + Sbjct: 508 DYLVLDNGRIKTTNKAKQLLNLVPKNLKSPSLTAVWEKQLDNIAKNKLSKDKFLNDV 564 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 271 bits (694), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 197/610 (32%), Positives = 308/610 (50%), Gaps = 61/610 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA- 59 M+L IAEKPS+A A + +K DG+IE G +TW +GHLLE D A Sbjct: 1 MKLIIAEKPSVAIDTAKAISPKFQKKDGYIEAGE-YTITWAVGHLLE------IDDTIAP 53 Query: 60 -RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W L LPI+PEK++ + KQ N++K + +A EI D REG+L+ +L Y Sbjct: 54 KEWKLETLPILPEKFEYKVSKGKNKQFNIVKSLVKKADEIFVNTDAGREGELIARLILLY 113 Query: 119 LQLAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + R ++ L + R + + + L S LAR ++DWL GIN+T Sbjct: 114 --SGWNGWDKTYRFWTSEALTKNVILRELKARKPAKNWDSLFYSGLARQQSDWLVGINLT 171 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T++ G V S+GRVQTPVL L+V RD EI+NF K +++++A + ++F Sbjct: 172 RALTVI---VGDGSVWSIGRVQTPVLKLIVERDLEIKNFKPKPYWQLEA-VFEKDSQKFK 227 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A +E ++D+ + E A+V K+ + AP FS++ L Sbjct: 228 AK-LLNEKDTIFEDK------NKIWEIFKALKDKDKAVVKEIEKKQHKKYAPPLFSITTL 280 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A KRFG +AQ L + Q LYE K I+YPR++ ++L +E+ + + V N + + Sbjct: 281 QMTANKRFGFTAQKTLMLAQDLYEA-KYISYPRTEAQHL-DENPSTKDLVKNILKKLGEE 338 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLM 412 L + V + R +D K+ H+AIIP ++ L ++ K+Y LI ++L Sbjct: 339 QLIENV--DKVGKRVFDSSKLTDHYAIIPMNLLTEEKAKKEGLNQDHLKIYELIKNRFLA 396 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG--TPLPVVAKG 470 F P + LDI +F A + GW+ + +R++E+D PLP + KG Sbjct: 397 VFMPPYEYETTKAILDIDGYQFTASGKVELSLGWKAI----DREDEDDKIEAPLPQLEKG 452 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + V+E +T+PP H+T++TLL+ M + LGT ATRAG Sbjct: 453 DMVHKISQRVIEDKTKPPAHYTESTLLNKMKQLE-----------------LGTGATRAG 495 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQC-- 586 II+ L R ++ KG+ + +T+ G AL + E A+ P MT+ WE L QI ++ Sbjct: 496 IIQTLKDRFYIKNKGKSLIATEKGFALIEKIKDKEFAS-PKMTSKWEQQLEQIYTQKLGK 554 Query: 587 -RYQDFMQPL 595 Y+DF+ + Sbjct: 555 KGYEDFLNQI 564 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 271 bits (693), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 179/603 (29%), Positives = 295/603 (48%), Gaps = 44/603 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+AR IAD L ++K +G+IE +VTW +GHL+ A P+ YD+ Y W Sbjct: 5 LILAEKPSVARDIADALHIKNKK-NGYIE-NEKYIVTWALGHLVTNAAPEQYDASYKEWK 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLPI+P+ + +KQ ++K + + +I+ A D REG+L+ +LD + Sbjct: 63 LEDLPIIPKYMKTIVIGKTSKQFKIVKSLILDKKVKDIIIATDAGREGELVARLILDKVG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ +QR I+ + +A++ L+ + L +ALAR+ ADW+ GIN TRA Sbjct: 123 ----NKKPIQRLWISSVTKKAIQEGFKHLKDGRAYNSLYHAALARSEADWIVGINATRAL 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T Y LS+GRVQTP + LV R ++I +F + ++ + + Sbjct: 179 T-----TKYDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYYTLSIKV------------ 221 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E + + ++ E + ++ Q V K + ++L+ +Q + Sbjct: 222 ---DGYEFTFNTQKHFKNKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQLYNLTDIQQD 278 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-----SVHA 355 A +RF + + L+ Q LYE HK++TYPR+D YL + + + A+ H Sbjct: 279 AYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQALLATNYKSHV 338 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQF 414 +L+ Q P + ++D KV HHAIIPT R S L++ E K+Y LI ++L Sbjct: 339 RELIGQSF-SPKMS--IFNDSKVSDHHAIIPTEVRPSLEQLSQREFKIYMLIVERFLESL 395 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 + + ++ F K + G++ L KE + + V+ G + Sbjct: 396 MKPYEYEGVTVNFEVGDLMFSLKENIPKQLGFKAL---KEDTLQPSKSHQFVI--GQQFK 450 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGII 532 +K ++ E +T+PP +F + +LL AM ++Q +K + L+ T G+GT ATRA II Sbjct: 451 VQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTGGIGTVATRADII 510 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 + LF L + I T GK + P T P +TA WE LTQI + + + FM Sbjct: 511 DKLFNMNALEVRDGKIKVTSKGKQILELAPSELTSPLLTAQWEEKLTQIEKGRYNSKKFM 570 Query: 593 QPL 595 + Sbjct: 571 DEM 573 >UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis Bt407 RepID=C3CTB0_BACTU Length = 787 Score = 268 bits (685), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 190/626 (30%), Positives = 307/626 (49%), Gaps = 56/626 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTW--CIGHLLEQAQPDAYDSRYAR 60 L IAEKPSL R I + G+ + + GH + PD Y +A+ Sbjct: 8 LLIAEKPSLMREIQS----------AYHTFGHKDTIEFKSFAGHTMGLINPDKYKEEWAK 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASE--IVHAGDPDREGQLLVDEVLDY 118 W+LA LP+VP+K+ +P IK+ + + I++ DP REGQ + D Sbjct: 58 WDLATLPLVPDKFLYEPTKDKLDMYKDIKKAIKNGNYDYIINGCDPGREGQHIFFSFYDS 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADWLYGINM 176 + V+R +DL + ++RA+D LR +E + ++ RA DWL G+N Sbjct: 118 IGC----NLPVKRIWHSDLTEKELKRALDNLRDENEPALSNMTKASKLRAYFDWLIGMNF 173 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA++I+G +++GRV TP L ++V R+ EI+NFV K+F+E++A F Sbjct: 174 TRAFSIVGGKK-----MNLGRVMTPALKVLVDRELEIKNFVPKNFWEIEADFGKYKGVHF 228 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 +D + + + A+ +++ +S + V N +++ + AP SLSA Sbjct: 229 N------------EDGDTQFWKQEDAQKIIDSLS-TDSTVKIVNQEKDVKYAPQLHSLSA 275 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA +G + Q L+I Q LYE K ++YPR+D +L + + A+M + P Sbjct: 276 LQNEANSVYGYTMQETLNITQTLYE-KKFVSYPRTDSSHLTKA-ISNDFAIMLRPLQNIP 333 Query: 357 DL-------LPQPVVDPDIRN--RCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLI 406 +L + + DI N + DDKKV H+AI+PT S LT+ E VY LI Sbjct: 334 ELADKTKAIINDSKILSDIANNKKYVDDKKVSDHYAIVPTGLSPDFGRLTDKEINVYMLI 393 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 A+++L F P V +K + + F L G+ L K +D LP Sbjct: 394 AKRFLSIFLPPMVSQKTSVVTENNGHLFKTSGSVLESIGFMALYNYKAQD-----NMLPP 448 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + KG+ + +K E++ +QT P +TD TL AM RF+ D +LK++L+ G+GT A Sbjct: 449 LKKGEMVSLKKAELITKQTSKPGRYTDRTLNIAMENAGRFIDDDELKEVLKEAKGIGTPA 508 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQ 585 TR GI+E L + +K + +T+ G + SL T P++TA WE L++I Q Sbjct: 509 TRGGIVEKLVSLNMIERKKKSFFATEYGIGIIQSLNGHDITSPELTAKWEQKLSEIEANQ 568 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV 611 F + ++ + + ++ K+ V Sbjct: 569 FDPNVFYKEMIAYIQKEVEDLKKLKV 594 >UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepID=Q8CS09_STAES Length = 718 Score = 267 bits (683), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 187/634 (29%), Positives = 313/634 (49%), Gaps = 57/634 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIEC-----GNGQVVTWCIGHLLEQAQPDAYDSR 57 L IAEKP+ + + L DG+IE +VTWC+GHL++ A + YDS Sbjct: 4 LIIAEKPNQVKKYVEALGNSFNNKDGYIELESELFDKKVIVTWCVGHLIQLAHMEDYDSN 63 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRF---LHEASEIVHAGDPDREGQLLVDE 114 +W+ LP +PE + + +KQ +IK L+ SEI+ A DPDREG+ + Sbjct: 64 LKQWSKDTLPFIPEDFIFKVSDYGSKQFKIIKELCENLNSDSEIIIATDPDREGEAIARY 123 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 VL+ ++ K +++R N P+ ++ A L+ + + A AR+ ADWL G+ Sbjct: 124 VLN--KIPCTKNLKLKRLWANTQEPEGLKLAFKNLKDADDTYRFYLEAEARSIADWLVGM 181 Query: 175 NMTRAYTILGRNAGY-QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 N TR T+ + G +GV SVGRVQTP L +V +R+ EI+NF +K ++E +V Sbjct: 182 NFTRYVTLEMKQLGIDEGVFSVGRVQTPTLYMVYKRNNEIKNFESKTYYE----MVAKDK 237 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 E A+++ + + + L E+ +N S ++KR + AP F Sbjct: 238 ENENAVFKSEHKFDSIDE-----FEQFLNENNLNCECEGEIKEISISEKR--KVAPNLFK 290 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L +Q A +++G + L I Q LY+ L +YPR+DC + F ++ Sbjct: 291 LGGIQKVANQKWGYTLDKTLSIVQSLYDKGYL-SYPRTDCSLITHSEFEYLKDNFSSYCK 349 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAKVYNLIARQ 409 + Q ++P R + +D KV H+AIIPT + N +++E K+Y+ + ++ Sbjct: 350 LLNIEIEQKNIEP--RTQYVNDSKVLEHYAIIPTKQIPENDVYNNFSDDEKKIYDEVVKR 407 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD---------EEND 460 ++ F D ++ + I L I +F E GW+ LL S+ ++ +EN+ Sbjct: 408 TMLMFMEDYIYSETKIVLCIENVEFKLTGNVAKEQGWK-LLDSENKNSKEKLLPNYKENE 466 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSA---MTGIARFVQDKDLKKILR 517 L +V K E T+PP++ T+ATL M ++F+++++LK L+ Sbjct: 467 KLSLNLVPK------------ELNTKPPKYLTEATLGGEGGLMENCSKFIENEELKGNLK 514 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-TRPDMTAHWES 576 G+GT ATR+ I++ L RG+L K +++ T G L +L +MTA+WES Sbjct: 515 EVHGIGTPATRSSIVKSLIDRGYLETKKKHLMITPKGTLLCSALENTNLVSVEMTANWES 574 Query: 577 VLTQISEK--QCRYQDFMQPLVGTLYQLIDQAKR 608 L ISEK + R +F+ + + Q+I+ + Sbjct: 575 TLKDISEKGHRIRQNEFIDSIKQYIKQMINSDNK 608 >UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A6TMD4_ALKMQ Length = 775 Score = 266 bits (679), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 188/642 (29%), Positives = 328/642 (51%), Gaps = 62/642 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+IAEKPS+A A L K DGFIE N VVTWCIGHL+ + PD YD +Y +W Sbjct: 5 LYIAEKPSVALEFAKTLNIKGNKKDGFIE-SNEAVVTWCIGHLVTMSYPDKYDDKYKKWV 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQL---LVDEVLD 117 L DLP +P K++ + +V KQ ++IK + + S I D REG+ LVDE+++ Sbjct: 64 LKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVN 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 K + +R I+ + +++ + + E+ L +A RA+ D+L GIN + Sbjct: 124 V------KGKTKKRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFS 177 Query: 178 RAYTI-----LGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 R T+ L + G + V++VGRV T VLG+VV+R+ EI FV ++++ ++ Sbjct: 178 RLLTLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLD 237 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPL-------AEHVVNRI----SGQPAIVTSYN 280 + W+ E+ Y + LL++ + AE + + + A+V + Sbjct: 238 QSMDYDGEWKAIESSNYYMSD---LLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIK 294 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE-- 338 K+E+++ PL ++L+ LQ E +K+ ++ L + QKLYE K+ITYPR+D R L Sbjct: 295 KKKETKNPPLLYNLAELQNELSKKLKINPDETLKVAQKLYE-KKMITYPRTDARVLSNAV 353 Query: 339 -----EHFAGRHAVMNAISVHAPDL----LPQPVVDPDI-----RNRCWDDKKVDAHHAI 384 + G V + + D Q +V+ + + + +DK + H+AI Sbjct: 354 AKEIHSNLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAI 413 Query: 385 IPTAR--SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLA 442 IPT S LT+ E + + LI R++L F P A+F + I I F ++ Sbjct: 414 IPTGEGLGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCI 473 Query: 443 EAGWRTLLGSKERD---EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSA 499 + G+ +L ++D + L + KG + K E+ E +T PP+ ++ +++ A Sbjct: 474 QEGYLEILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILA 533 Query: 500 MTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF--LTKKGRYIHSTDAGKAL 557 M + ++D++L++ ++ + G+GT ATR+GI+ L + + L KK + + T G+++ Sbjct: 534 MESAGKLIEDEELREKIKGS-GIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESI 592 Query: 558 F----HSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 + S+P + +P++TA WE L I+ + + ++M L Sbjct: 593 YDVVDESIPSLL-KPELTASWEKGLGMIANGEIQCDEYMIKL 633 >UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytogenes 08-5578 RepID=D2P3C5_LISMO Length = 714 Score = 265 bits (678), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 186/618 (30%), Positives = 308/618 (49%), Gaps = 34/618 (5%) Query: 3 LFIAEKPSLARAIADVLP--KPHRKGDGFIEC-----GNGQVVTWCIGHLLEQAQPDAYD 55 + +AEKP+ A A+ + K HR GF E + +T +GHL++ P YD Sbjct: 4 VILAEKPNQALTYAEAMHHFKKHR---GFYEVQDELFADQTFITHGLGHLVDLFMPGQYD 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 + +W++ +LPI PE + +PS +Q ++K+ L EA+ I+ A D DREG+L+ E+ Sbjct: 61 PKLKKWDMTNLPIFPETIRYYVKPSNQEQFQIVKKLLSEATTIIIATDCDREGELIAREI 120 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L+ +L+ E + +QR IN L +A+ L V A R ++DWL G+N Sbjct: 121 LNQTKLSFEGK-NIQRLWINSLEKEAIREGFQSLWHAGHTYFKYVEAQTRQKSDWLIGMN 179 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 T Y++L + G +GRVQTP L +V +R++EIENF + FE+ + +++ Sbjct: 180 FTPLYSLLLQEYGSFSQYPIGRVQTPTLMMVYKREKEIENFKPRKMFEL-FYENKMEEQK 238 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 A + + ++ L R + RI A V + +K E ++PL FSLS Sbjct: 239 ILAKIKTHPLFDTKEEVYAFLKERNM------RIGPTEATVLNMVEKEEKHASPLLFSLS 292 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQI K+F S + L QKLYE K ++YPR+DC ++ ++ F+ + A Sbjct: 293 NLQILMNKKFKYSPKETLQGVQKLYEK-KWLSYPRTDCTFITQKEFSYLKMKLQEYKAFA 351 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT----ARSSAINLTENEAKVYNLIARQYL 411 + P ++PD R D+ +V+ HHAIIPT + + LT E ++Y + + Sbjct: 352 HIEVYTPNLEPDF--RYVDNHEVNEHHAIIPTRIIPSAAEFSKLTTLEKQIYTWVLHVTI 409 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P + ++ ++L I + F AK R + GWR ++ + E+ L GD Sbjct: 410 AMFAPPMLIKEIAMDLRIGELLFEAKERTPVDMGWRKIILGNNQKEKISRQSLSNFHIGD 469 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV-QDKDLK-KILRATDGLGTEATRA 529 + G +E+ +PP FT+ L+ AM + Q K++ K++ G+GTEATRA Sbjct: 470 TIHGFLGG-IEKDKKPPSPFTEGALIHAMKNAGKKAGQSKEMGLKVM----GIGTEATRA 524 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQCR 587 ++E L + +L ++ TD GK L + + + DMTA E+ L I E Sbjct: 525 DVLEKLKNQDYLKLTKNKLYVTDKGKELGRVIENDPLLSNIDMTASLETALHSIGEGITT 584 Query: 588 YQDFMQPLVGTLYQLIDQ 605 ++F++ L G + + I + Sbjct: 585 QEEFLKNLKGMIQKYIQK 602 >UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8_9BACE Length = 711 Score = 263 bits (672), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 195/618 (31%), Positives = 316/618 (51%), Gaps = 53/618 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKPS+AR IA + RK +G+ GNG VTW +GHL++ A PD Y + R Sbjct: 1 MITILAEKPSVAREIARI-TGATRKEEGYY-TGNGYHVTWALGHLVQPALPDGYGFKGFR 58 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + LP++PE++ L PR + KQ+ VI + E+ I+ A D REG+ Sbjct: 59 RD--SLPVIPEEFMLIPRQVKTDKGYKADAAAVKQIKVITKLWQESEGIIVATDCAREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L + YL +R I+ L A+ + + L+ E+ L ++A AR+ AD Sbjct: 117 L----IFRYLYAYTGCTLPFRRLWISSLTDTAIRKGLKELKDGHEYDDLYLAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ A +G SVGRVQTP L +V +R E F + ++ H Sbjct: 173 WLVGINGTQALTV----AAGRGTYSVGRVQTPTLAMVCKRYRENRRFTPEPVHQL--HFS 226 Query: 230 TPADERFTAIWQPSEACEPYQDE-EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 P+ T + S + +QD+ E +L+ + + A VT K + E+ Sbjct: 227 VPSANAGTVVKFAS--VKKWQDKNEAAILYNKVKAKMC-------ATVTKVEKKEKVENP 277 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA + G +A+ L++ QKLYE KL+TYPR+ R++PE+ FA + Sbjct: 278 PLLYDLTTLQKEANTKHGFTAEQTLELVQKLYEA-KLVTYPRTSSRHIPEDVFAEIPLLF 336 Query: 349 NAISVHAPDLLPQPVVDPD-IRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 ++ H+ L +V+ D + R D KV HHA++ T + + L +NE +Y++IA Sbjct: 337 ERLAGHST--LSDKIVNLDGLNRRSVDASKVTDHHALLVTP-NRPLALYKNEQIIYDMIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG--------KFVAKARFLAEAGWRTLLGSKERDEEN 459 + + F + V + ++ F AK + +AGWR + G E E+N Sbjct: 394 GRMVEAFSEECVKDTATVVAEVVPDAGERCEGLTFEAKGCIVRKAGWRGVYG--EYGEDN 451 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR-FVQDKDLKKILRA 518 T LP +GD L+ + T+P T+++LL+AM R V+D++ ++ L+ Sbjct: 452 GNTALPDWTEGDTLVMAGCSMSSGMTRPKPLHTESSLLAAMETAGRDDVEDEEARQALKD 511 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESV 577 G+GT ATRA IIE L +R ++ + + + T+ G AL+ + +M +MT WE+ Sbjct: 512 C-GIGTPATRAAIIETLIRREYMVRVKKSLVPTEKGLALYSIVKDMDIANVEMTGRWEAE 570 Query: 578 LTQISEKQCRYQDFMQPL 595 L +I + + ++ FM+ + Sbjct: 571 LAEIEKGKTPHEAFMRDI 588 >UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3R3E4_9BACE Length = 698 Score = 261 bits (668), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 193/620 (31%), Positives = 298/620 (48%), Gaps = 67/620 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ +K DG+I GNG +VTW +GHL+ A P Y Y R Sbjct: 1 MIAIIAEKPSVGQEIARVVGATEKK-DGYI-TGNGYMVTWALGHLVSLALPGTYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++PE ++L R T +QL VI E I+ A D REG+ Sbjct: 57 TTAEDLPMLPEPFRLVERQIRTDRGMVTDIAAGRQLKVIDGVFSECDSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L + +R + L +A+ + + LR E+ L +A +RA+AD Sbjct: 117 LIFRWIYSHLGCT----KPFKRLWFSSLTDEAIRKGMADLREGYEYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N +RA + +A S+GRVQTP L ++ R +E NFV+ ++++ HI Sbjct: 173 WLVGMNASRALAAVSGSANN----SIGRVQTPTLAMICARFKENRNFVSTPYWQL--HIT 226 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESESA 288 E P E + D++ AE RI G +T + A Sbjct: 227 LKQGEAHRLFIHP----EHFGDKKA-------AETAYGRIIPGSAVTITKVERGTVFQQA 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L++LQ + L+A L I Q LYE KL++YPR+ RY+PE+ Sbjct: 276 PLLYDLTSLQKDCNIHHDLTADKTLSIAQSLYE-KKLVSYPRTGSRYIPED--------- 325 Query: 349 NAISVHAPDLLPQPVVDPDIR------------NRCWDDKKVDAHHAIIPTARSSAINLT 396 I + P LL + + P R R D KV HHA+I T + L+ Sbjct: 326 --IMANIPALLEKIIAMPLFREYGRTFDFSALNTRSVDTTKVTDHHALIITGVAPE-ELS 382 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE-- 454 E E+ VY LIA + L F P + ++E F +++ F+ GWR + KE Sbjct: 383 EAESAVYTLIAGRMLEAFSPPCEKERLLMECMCGGMDFRSRSAFIVNTGWRAVFARKEDR 442 Query: 455 -RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 +DE DG + A+G + + +++T P +T+ATLL+AM + + D + + Sbjct: 443 EKDEPEDGGGTALFAEGGLVPLSGRGLSQKKTLPRPLYTEATLLAAMENCGKDITDGEAR 502 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTA 572 + ++ + G+GT ATRA II LFKR ++ + G+ I T+ G L+ S+ + M ++T Sbjct: 503 ETVKDS-GIGTPATRAAIITTLFKRNYVERSGKSILPTEKGLYLYESVKDMMVADAELTG 561 Query: 573 HWESVLTQISEKQCRYQDFM 592 WE L +I + FM Sbjct: 562 TWERALARIEGRTLDPDSFM 581 >UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q181Z2_CLOD6 Length = 742 Score = 260 bits (665), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 180/618 (29%), Positives = 311/618 (50%), Gaps = 39/618 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD-SRYA 59 M+L +AEKPS+A+ IA L R+ DG+ E GN ++T+ +GHL+ YD +Y+ Sbjct: 1 MKLVLAEKPSVAKTIASFLGAKTRQ-DGYFE-GNDYIITYAVGHLVSLYDMKDYDKDKYS 58 Query: 60 -RWNLADLPIVPE-KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 W + + P VPE K++ + S TKQ N +K+ L+ + +++A D DREG+L+ + Sbjct: 59 GSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLI 118 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L + ++ V+R L+N+ P+ + R I L+ E L + R DWL GIN Sbjct: 119 F----LLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGIN 174 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 T T+ G +L++GRV P + LV RD EI NFV K ++E++ H A E Sbjct: 175 FTSVATL---KYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEY 231 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 + + +E + A ++ I+ + + E AP FSL+ Sbjct: 232 ---------KGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLT 282 Query: 296 ALQIEAAKRF-GLSAQNVLDICQKLYETH---KLITYPRSDCRYLPEEHFAGRHAVMNAI 351 +LQ ++ ++ VL++CQ LYE + ITYPR+D +L E + ++ + Sbjct: 283 SLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKL 342 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 V L + + R +D KVD+H AIIPT +L+++E VY+ I +++ Sbjct: 343 KVG---LEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPK-SLSKDEQLVYDAIKDRFV 398 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A + I+ ++ F+ K + L G+ L ++E+ND LP+V K D Sbjct: 399 ANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGY---LEVYNKEEKND--LLPLVNKDD 453 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + + + +QT PP+ +T+ TLL AM + V ++D + + +GT ATRA + Sbjct: 454 VVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDT--TVLSGYSIGTSATRADV 511 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQD 590 ++ + + G++ KKG+ T+ GK L P + D T E L+ I + + ++ Sbjct: 512 LKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKE 571 Query: 591 FMQPLVGTLYQLIDQAKR 608 ++ ++ +YQ ++ K+ Sbjct: 572 YLTNIISFIYQNVNIIKQ 589 >UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WNM4_EGGLE Length = 741 Score = 260 bits (664), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 196/637 (30%), Positives = 309/637 (48%), Gaps = 65/637 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IAD + H + DG+IE G G +++WC GH+++ P Y W+ Sbjct: 4 LIIAEKPSVARGIADAV-GAHERRDGYIE-GGGYLISWCRGHIIDLDFPQNYPQWSGHWS 61 Query: 63 LADLPIVPEKWQLQPRPSVT--KQLNVIKRFLHEASE--IVHAGDPDREGQLLVDEVLDY 118 ++ LP++PE+W R SVT +Q V+K L A +V+A D DREG+ + V + Sbjct: 62 MSQLPMIPERW----RWSVTAPEQYKVLKGLLDRADVELVVNACDADREGEGIFRRVWTH 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R L P+ V + + S++ L +A RA+ADWL G+N +R Sbjct: 118 SGC----KKPVRRFWSTSLVPEQVRTDLAHAKPLSDYDGLADAAEGRAKADWLVGLNASR 173 Query: 179 AYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 A + L Y+G LS GRVQTP L LVV R I F + FF+V+ + A R Sbjct: 174 ALSCL-----YEGSRLSAGRVQTPTLALVVERTRAIRGFKSVPFFQVECSVGRTAHVRLA 228 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +L R A + G + ++E AP + L+ L Sbjct: 229 G---------------EKLKTRQEALRRAHAAVGSQCAILKVERRQEKCRAPKLYDLTGL 273 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q +A+ R GL+A+ L+ Q LYE KL TYPR++ RY+ E V++AI+V P Sbjct: 274 QRDASTRAGLTAEETLNALQTLYE-KKLATYPRTESRYIGESDIPETARVLSAIAV--PG 330 Query: 358 LLPQPVVD------PDIRNRCWDDKKVDAHHAIIPTARSSA---INLTENEAKVYNLIAR 408 ++ + D+ R DD KV H AI+PTA A L E V LI Sbjct: 331 IVGEAAAAGFDASRSDV-ARVADDSKVHGHGAILPTALLDAKEMAKLDGAERSVAILICC 389 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL----------LGSKERDEE 458 + + A K +E ++ + A + +A W + G DE+ Sbjct: 390 RLMAATMDPATKLKTKVEGEVNGDAYTASGSTVTDASWIAVDEACRAALAGGGKAAEDED 449 Query: 459 NDGTPLPV-VAKGDELLCEKGEV--VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 ++ +P + +GD G+V + +T PP+ +TDATLLSAM R ++D++LK Sbjct: 450 DEAQDIPADIEQGDSFTVADGDVRVKDGKTTPPKPYTDATLLSAMEHAGRSIEDRELKAA 509 Query: 516 LR----ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMT 571 + + GLGT ATRA +IE L + ++ ++G+ + +T+ G+ L + + P++T Sbjct: 510 IEDDSMHSGGLGTPATRARMIEKLIEAKYIRRRGKTLSATERGETLIDIVCDSLKTPELT 569 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 A WE L+ + + DF+ + G ++ +R Sbjct: 570 AKWELALSHVERGEGSLSDFLSGIEGYTAAVVSDLER 606 >UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL7_CLOBB Length = 718 Score = 259 bits (662), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 178/634 (28%), Positives = 306/634 (48%), Gaps = 57/634 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD L RK DG+ + G +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADALNIKTRK-DGYFK-GEEYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQ 109 + P +PE +Q + + KQ+N+IK + + ++ A D DREGQ Sbjct: 61 RMEKFPFIPESFQYKVKCDNIDRTVEDKGAAKQINIIKSLIEQEDVDGVISATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ +YL + ++ + R L+N+ P V++ + L+ N E L + + R D Sbjct: 121 VIADELFNYLNI----QKPIYRLLLNEWTPDEVKKGMGSLKENKEMQFLQDAGIGRQWTD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T L +++GRV P L ++ RD+EIENF A ++++ + Sbjct: 177 WIIGINLTSVST-LKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFEATTYYKLTSTFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 ++E F ++ Y+ E + + + +++V + G A + +++ + P Sbjct: 236 NSSNEEFDGLY--------YEKESEKFEDKSVLDNLVKLLDGTNATIIDKQTEKKKDYPP 287 Query: 290 LPFSLSALQIEAAKRF-GLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ ++ G ++ VL + Q LYE K TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYE-KKYTTYPRTASVVLEESLEDRARKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIR----NRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYN 404 N + + P + DI+ R +D+ KV++H AI PT L+++E VYN Sbjct: 347 NTLKIGLP-------YEKDIKFIKTKRVFDNSKVESHSAITPTYIKPN-GLSKDEEIVYN 398 Query: 405 LIARQYLMQFCPDAVFRKCVIEL----DIAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 I +++MQF P A F + I L + +G+F++K + GWR + +D Sbjct: 399 AIKNRFIMQFMPIAEFEETKIRLKPSNEEIQGEFISKGKVQLVEGWRVVEKIDTKD---- 454 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD-----LKKI 515 T LP+V +++ +V + +PP+H T+ TLL M + ++ K+ ++ I Sbjct: 455 -TILPMVNVDEKVDIVSNKVNKVTKKPPKHHTEKTLLRVMETCGKGIEGKEDSEEMMQSI 513 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHW 574 L +GT ATRA I+ L G++ KG+ + T G + P + + T Sbjct: 514 LNGF-SIGTPATRAETIKKLKDIGYIGTKGKSLICTQLGINIVEIFPVQELLDLEYTGRL 572 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 ES L+ I + + + DFM + +D+ K+ Sbjct: 573 ESTLSDIEKGKFKKSDFMSLIYDFTNNAVDKIKK 606 >UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID=C9BSW4_ENTFC Length = 801 Score = 258 bits (659), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 179/615 (29%), Positives = 315/615 (51%), Gaps = 31/615 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN----GQV-VTWCIGHLLEQAQPDAYDSR 57 + +AEKPS A+A A+ + R +G+ E + G+V +T+ GHL++ P AY+ R Sbjct: 63 VILAEKPSQAKAYAETFQQQKRH-EGYYEISDPLFAGEVTITYGFGHLVDMVAPGAYEER 121 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +A+W+L +LPI PE ++ + Q +++KR L A I+ A D DREG+ + ++ Sbjct: 122 WAKWSLENLPIFPETFRYEVPMDKRAQFSIVKRELQSADTIIIATDGDREGEAIAWSIIR 181 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 A K + R IN L +A+ L+ + P A AR ADWL G+N + Sbjct: 182 QAN-AFSKEKNYLRLWINSLEKEAIYEGFKNLQPGKNYFPKYKEAQARQNADWLIGMNGS 240 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 Y++L + G G S+GRVQTP L ++ + EEI++F + +FE + ++T +F+ Sbjct: 241 PLYSLLLQRKGIDGSFSLGRVQTPTLYMIYQLQEEIKHFKKETYFEGEG-LITTNKGQFS 299 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 P +A + Q+E + + + L H + Q + K + +P FSLS+L Sbjct: 300 GKIVPKKAFKT-QEELTKEIEK-LGAH----LGKQNGRILEVTKKEKRLHSPRLFSLSSL 353 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE-EHFAGRHAVMNAISVHAP 356 Q + + SA+ LD Q LYE+ K ++YPR+D Y+ E EH ++ + + Sbjct: 354 QTKMNQLMKASAKATLDAAQGLYES-KFLSYPRTDSFYITENEH----QYLVKHLQNYKK 408 Query: 357 DLLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAKVYNLIARQY 410 L + V +I + R D KKV HHAIIPT + L++ + +Y + R Sbjct: 409 FLGIEEVQTTEIKAKKRYVDAKKVQEHHAIIPTKTIPTPARFAKLSKLQQAIYLQVLRTT 468 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + F D ++ + + + + K + + + GW+ +L K + +E LP + + Sbjct: 469 VAMFAADYIYEETTVMTGVQQLKLKSIGKIPLQQGWQEILRIKSKKKE--AQTLPPIVEN 526 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 +E E + +E++TQPP+ +T+ TL++AM + + + + ++IL+ +G+GTEATRA Sbjct: 527 EEAEVEL-KSMEKETQPPKPYTEGTLITAMKTAGKTLDNDEAQEILKEVEGIGTEATRAN 585 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQCRY 588 IIE L ++ ++ I T G L ++ + T +MTA WE L +I +++ Sbjct: 586 IIENLKQKHYIEVNKNEITVTPKGITLCKAVANEPLLTSAEMTARWEGYLRKIGKQEGTP 645 Query: 589 QDFMQPLVGTLYQLI 603 F++ + + L+ Sbjct: 646 SVFLENIKKFILHLL 660 >UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=A8U7S1_9LACT Length = 701 Score = 257 bits (657), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 184/615 (29%), Positives = 298/615 (48%), Gaps = 61/615 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+ + IA VL +K IE G +VTW +GHLL P+ Y +A W+ Sbjct: 14 LIIAEKPSVGKEIARVLG-ATQKSKTHIE-GKDVIVTWALGHLLGLKMPEEYKKEWATWD 71 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L LP++PEK P + QL IK+ + V A D REG+L+ +L+Y+ Sbjct: 72 LNTLPLIPEKMLTTPLKNTRSQLKAIKQLADRKDIGSAVIATDAGREGELVARWILEYVH 131 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++R I+ +A++ ++L+ + ++ L SA+AR+ ADWL G+N+TRA Sbjct: 132 F----NKPIKRLWISSQTDKAIKEGFNQLQPSKKYDTLYDSAVARSEADWLIGLNVTRAL 187 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ YQ LS GRVQTP L +V +++ +I++FV + F+ V+ I D + I Sbjct: 188 TV-----KYQDSLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLVI----DGKKATI- 237 Query: 241 QPSEACEPYQDEEGR-LLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 QD R R AE +V + + IV +K+ + APLP+ L+ LQ Sbjct: 238 ---------QDSALRKFSERQKAEDLVASLKNKSVIVKEIKEKQSIQQAPLPYDLTELQR 288 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA R+ SA+ L + Q LYE HK+++YPR+D +YL ++ + AI APD + Sbjct: 289 EANLRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMIGTMKERVAAIQNFAPDEV 348 Query: 360 PQPVVDPD--IRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCP 416 + + ++ KV HH IIPT R + +E K+Y ++ +++ F P Sbjct: 349 KGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPEKMEADELKIYRMVVERFIGLFLP 408 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-GTPLPVVAKGDELLC 475 K I A F + + E GW+ KE ++++ G L +E L Sbjct: 409 AYNVSKTTIVFSAATTLFSLQQEEVIEKGWK-----KEVQKQSEKGYQL------NEQLT 457 Query: 476 EKGEVVERQ-TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 + ++ Q T+ P ++ TLL M +GLGT ATRA IIE Sbjct: 458 QPTYTIQMQLTEAPARLSEGTLLQNM-----------------EKNGLGTPATRAEIIEK 500 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 L K + + + +T G+ L + P++T WE L +I++ + + F++ Sbjct: 501 LIKSDLMERNQNKLSTTPKGQQLLTLVNPALVTPELTRKWEEALEEIAKGTLKKEVFLKQ 560 Query: 595 LVGTLYQLIDQAKRT 609 + +L+ + K + Sbjct: 561 IKNETARLVTEIKNS 575 >UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LRS2_CLOB8 Length = 722 Score = 255 bits (651), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 178/634 (28%), Positives = 302/634 (47%), Gaps = 56/634 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD R+ DG+ E GNG +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADAFNVKTRR-DGYFE-GNGYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFL--HEASEIVHAGDPDREGQ 109 P +PE + + + KQL +IK + + IV A D DREGQ Sbjct: 61 RFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ Y ++ ++ + R L+N+ P V+ ++ L+ N E PL + + R +D Sbjct: 121 VIADELFGYFKV----KKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T L +++GRV P L ++ RD+EIENF A ++++ ++ Sbjct: 177 WIIGINLTSVST-LKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T A+E F ++ Y+++ + + + ++R+ G A + + + E P Sbjct: 236 TSANEEFEGLY--------YENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPP 287 Query: 290 LPFSLSALQIEAAKRF-GLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ ++ G ++ VL + Q LYE KL TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYE-KKLTTYPRTASVVLEESLKDRAKKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIR----NRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYN 404 N + P + DI+ R +D KV++H AI PT + L+ +E VY+ Sbjct: 347 NTLKAGLP-------YEKDIKFSTSKRIFDSSKVESHSAITPTYIKPS-GLSSDEKIVYD 398 Query: 405 LIARQYLMQFCPDAVFRKCVIELDI----AKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 I +++MQF P A F + + L G FV+K + GW+ + E+ E D Sbjct: 399 AIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVV----EKIESKD 454 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD-----LKKI 515 LP + + + +V +PP++ T+ TLL M + ++ KD + + Sbjct: 455 -VILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQA 513 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHW 574 + + +GT ATRA I+ L G+L KG+ + T+ G+ L + P + + T Sbjct: 514 ILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRL 573 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 E L+ I + + +F++ + Q ++ K+ Sbjct: 574 EKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKK 607 >UniRef50_A5ZNQ6 DNA topoisomerase n=2 Tax=Clostridiales RepID=A5ZNQ6_9FIRM Length = 635 Score = 254 bits (648), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 173/568 (30%), Positives = 284/568 (50%), Gaps = 52/568 (9%) Query: 68 IVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDYLQLAPEK 125 ++PE W+ Q + S Q ++K LH A +EI+ A D REG+L+ V + E Sbjct: 1 MIPENWKYQIKESTKGQFRILKELLHRADVTEIICATDAGREGELIFRLVYN----QAEC 56 Query: 126 RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGR 185 + +R I+ + +A+ +L+ E+ L SA+AR+ ADWL GIN TR +T+L Sbjct: 57 KLPFKRLWISSMEEKAILEGFQQLKDGHEYDDLYYSAVARSEADWLVGINATRLFTVL-- 114 Query: 186 NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEA 245 Y L VGRVQTP L ++V R++ IENF + ++ V H++ + ++ Sbjct: 115 ---YHHRLIVGRVQTPTLAMLVEREKSIENFQKEKYYLV--HLLMDGLDAVSS------- 162 Query: 246 CEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRF 305 R+ + A ++ + + A + S +++ P + L+ LQ EA + Sbjct: 163 ---------RIKEKSAAVQMMEDMKDETAQILSVKKEKKKVQPPKLYDLTTLQREANRLL 213 Query: 306 GLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVD 365 G +AQ LD Q LYE KL+TYPR+D +YL ++ V+ A++ P++ + + Sbjct: 214 GFTAQQTLDYTQSLYE-KKLVTYPRTDSQYLTDDMEENALLVVGAVNSMFPEMSIKGS-E 271 Query: 366 PDIRNRCWDDKKVDAHHAIIPTARSSAINLTE---NEAKVYNLIARQYLMQFCPDAVFRK 422 PDI+ R + KKV HHAIIPT + ++L E ++ LIA + L + ++ Sbjct: 272 PDIK-RLLNSKKVSDHHAIIPTVEITNMDLKALPGGEKEILMLIASKLLCASEQEYIYES 330 Query: 423 CVIELDIAKGKFVAKARFLAEAGWRTL-------LGSKERDEENDGTPLPVVAKGDELLC 475 E+ F A + + + GW+ + G E + + P + G C Sbjct: 331 IKTEISCHGELFTASGKNVLQYGWKEVEERFFKSYGKNAEKPEEEESDFPDIKIGQVFEC 390 Query: 476 EKGEVVERQTQPPRHFTDATLLSAM--TGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + E T PP+H+T+ TLLSAM G + ++D + K GLGT ATRA IIE Sbjct: 391 VVVKFSEHFTAPPKHYTEDTLLSAMEHAGSSDTIEDAERK-------GLGTPATRAAIIE 443 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L ++GF+ +K + I T G+ L LPEM P +TA WE+ LT IS Q ++F+ Sbjct: 444 KLIEKGFIERKKKQILPTADGRNLIRILPEMIKSPKLTAEWENDLTLISRGQKNVEEFLF 503 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPG 621 + + +L+ + PV +++ + + G Sbjct: 504 EIEKMVTKLVSDNGQ-PVEEYQKLFSDG 530 >UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C9LK04_9BACT Length = 705 Score = 252 bits (643), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 200/655 (30%), Positives = 309/655 (47%), Gaps = 93/655 (14%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIEC---------GNGQVVTWCIGHLLEQAQPDAY 54 IAEKPS+AR IA ++ +++ +G++ G+ VVTW +GHL+ A P+AY Sbjct: 5 IIAEKPSVARDIARIVGASNKQ-EGYLASTPSADFQLEGSDYVVTWAMGHLIALAMPEAY 63 Query: 55 DSRYARWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGD 103 ++ + DLPI P +QL R P+ KQL VI+ +A I+ A D Sbjct: 64 G--FSAYKREDLPIRPNPFQLVVRQVRKDKEYHDDPAALKQLKVIRSCFDKADRIIVATD 121 Query: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 REG+L+ + +L + +R I+ L +A+ + L+ S + L SA Sbjct: 122 AGREGELIFRYIYQHLNCC----KPFERLWISSLTDKAIREGLSNLKPGSSYDNLYYSAK 177 Query: 164 ARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 AR+ ADWL GIN +RA +I R GY S+GRVQTP L +V RR +F + +++ Sbjct: 178 ARSEADWLVGINASRALSI-ARKGGY----SLGRVQTPTLAMVCRRYIANRDFSSVPYWK 232 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVT------ 277 + H ++EG L +E + S Q A+ T Sbjct: 233 LSVHT----------------------EKEGLSLKAIGSEDYESEASAQTALATLRSQSR 270 Query: 278 ----SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDC 333 S K + PL + L+ALQ +A +R G SA L I Q LYE K+ TYPR+ Sbjct: 271 LTVESVARKVTHTAPPLLYDLTALQKDANRRHGFSADKTLSIAQSLYE-KKITTYPRTGS 329 Query: 334 RYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI 393 RY+ E+ F A++ I L P+ + D+ KV HHAIIPT Sbjct: 330 RYISEDVFEEVPALLRKIG----KTLSNPLNIHSV-----DNAKVTDHHAIIPTGEMPT- 379 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRT----- 448 L+ +EA +YN++ ++ F PD+ + + F KA GW+ Sbjct: 380 GLSTDEANIYNMVVTRFAEAFSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQKEL 439 Query: 449 LLGSKERDEENDGT----PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA 504 + ++++++END LP + +G+ L E+ +T+P +T+ATLLSAM Sbjct: 440 VTDAEKKEKENDDELVLPSLPDLTEGEVLSLVSAEITAHKTKPKPLYTEATLLSAMENAG 499 Query: 505 RFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM 564 + V++ D +K + A G+GT ATRA IIE L R ++ + + I T+ G A++ + + Sbjct: 500 KEVKEDDKRKAM-AECGIGTPATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKDK 558 Query: 565 A-TRPDMTAHWESVLTQISEKQCRYQDFMQPL---VGT----LYQLIDQAKRTPV 611 +MT WE L I + + F Q + VGT L L + K PV Sbjct: 559 KIANAEMTGSWELALAAIEAGKMPSERFAQGINSYVGTICEELLSLSSEQKSYPV 613 >UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=C7XFN2_9PORP Length = 698 Score = 251 bits (642), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 192/622 (30%), Positives = 296/622 (47%), Gaps = 71/622 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ +K DG+I GNG +VTW +GHL+ A PDAY Y R Sbjct: 1 MIAIIAEKPSVGQDIARVVGATEKK-DGYI-VGNGYMVTWALGHLVSLALPDAYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++P+ ++L R T +QL VI L I+ A D REG+ Sbjct: 57 TAAEDLPMIPDPFRLVVRQVRTDRGMVTDIAAGRQLKVIGEVLAGCESIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL + +R I+ L +A+ + L+ + + L +A +RA+AD Sbjct: 117 LIFRWIYSYLGCT----KPFKRLWISSLTDEAIREGMASLKEGTGYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVL--SVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAH 227 WL G+N +RA A G + S+GRVQTP L ++ R +E NFV+ ++++ H Sbjct: 173 WLVGMNASRAL------AAASGSVNNSIGRVQTPTLAMICARFKENRNFVSTPYWQL--H 224 Query: 228 IVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI-VTSYNDKRESE 286 IV D E ++D+ +AE I+ + + +T + + Sbjct: 225 IVLKRDNGHRQFIHTKE----FKDKN-------MAEAAYKSITPRSVVTITKVKRGKIFQ 273 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 APL + L+ALQ + + L L I Q LYE KL++YPR+ RY+P++ A Sbjct: 274 QAPLLYDLTALQKDCNIHYDLPVDKTLAITQSLYE-KKLVSYPRTGSRYIPQDVMA---- 328 Query: 347 VMNAISVHAPDLLPQPVVDPDIR------------NRCWDDKKVDAHHAIIPTARSSAIN 394 H P LL + P+ R R D KV HHA+I T Sbjct: 329 -------HIPVLLEKITAMPEFREYRRSLDLSALNTRSVDAAKVTDHHALIITGIVPE-G 380 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE 454 L+E E+ VY LIA + L F P ++E F +++ +A GWR + KE Sbjct: 381 LSEAESTVYTLIAGRMLEAFSPPCEKELLLMECVCGGLDFHSRSTVIANPGWRAVFSRKE 440 Query: 455 ---RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 +DE +G+E+ + +++T P +T+ATLL+AM + + D Sbjct: 441 DREKDEPERDEGTASFTEGEEIPVMGHGLSQKKTLPKPLYTEATLLTAMENCGKEITDGQ 500 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDM 570 ++ ++ T G+GT ATRA II L KR ++ + G+ I T+ G L+ S+ + M + Sbjct: 501 AREAVKDT-GIGTPATRAAIITTLLKRDYIERSGKSIRPTEKGLYLYESVKDMMVADAKL 559 Query: 571 TAHWESVLTQISEKQCRYQDFM 592 T WE L QI + + FM Sbjct: 560 TGTWEKALEQIEGRTLDPESFM 581 >UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus RepID=D2J7B8_STAAU Length = 705 Score = 251 bits (641), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 177/609 (29%), Positives = 299/609 (49%), Gaps = 48/609 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAYDSR 57 + AEKPS AR A+ L H+K DG+IE N G ++TW GHL+E P Y + Sbjct: 4 VIFAEKPSQARDYANALGISHKK-DGYIEGVNPLFDGGVIITWGFGHLVELKLPKDYSNP 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W+L +LP P ++ + +KQ N++K +A +++A D DREG + L Sbjct: 63 INNWDLKNLPYRPSPFEYKVSEGKSKQFNIVKTLFKDADILINATDIDREGSNIFYSTL- 121 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 +L K + ++R IN L + +++ +L++N + A AR +D+L G+N++ Sbjct: 122 --KLTGVKNKTIKRLWINSLVEKEIKKGFQQLQNNHQDYQNYQEAYARQTSDYLIGMNLS 179 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 Y+ + + G Q V S+GRVQTP L ++ R IENF + F+E+ E Sbjct: 180 PVYSKIFQLQGVQDVFSIGRVQTPTLYMIYERYLAIENFKPETFYEIFGEF-----ESKN 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 ++ + +E L +H N + I+T + + S+P SLS L Sbjct: 235 GCYKGKAKIKTTDKQEIINLGE---KH--NLKDAKEGIITKLETQEKRTSSPKLHSLSTL 289 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF----AGRHAVMNAISV 353 Q + K++ S + +I Q LYE K+++YPR+DC Y+ E + ++MN + Sbjct: 290 QSKINKQYKYSPEKTKNIVQSLYE-KKILSYPRTDCNYITSEEYLYLKENLQSLMNVYNK 348 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAKVYNLIARQ 409 H + +P R R +++KV H+AIIPT++ + L+++E V + + Sbjct: 349 HFSIVYDKP------RARYVNNEKVKEHYAIIPTSQIPTPQNIEKLSQDEKYVLDEVVST 402 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 L F D V+ + IE ++ + F + GW+ L K +E++ LP + K Sbjct: 403 TLSMFANDYVYDETKIETNVNQLIFYTTGHTEIQKGWKILFKHK-GNEKSPEQQLPKLIK 461 Query: 470 GDELLCEKGEVVERQ--TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + C K + + TQ P+ +T+ L++ M +++ D++ +IL+ G+GTEAT Sbjct: 462 NE---CVKANIYSNKGITQSPKLYTEGQLITLMKSCGKYLDDEEA-EILKEIQGIGTEAT 517 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWESVLTQISE 583 R GII+ L + ++ + +H T G KA+ SL AT MTA WE L I + Sbjct: 518 RDGIIQSLKNKNYIKIEKNKVHITAKGILLCKAVKGSLLASAT---MTAAWEKRLKLIGQ 574 Query: 584 KQCRYQDFM 592 Q +F+ Sbjct: 575 GQANTDNFI 583 >UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FFH7_FLAJ1 Length = 689 Score = 251 bits (641), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 202/640 (31%), Positives = 313/640 (48%), Gaps = 74/640 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS AR IA VL + K DG++ GNG VTW +GHL+ P+ Y + Sbjct: 1 MKVVIAEKPSAAREIA-VLLGANEKKDGYL-AGNGYFVTWALGHLVGLGLPEDYGIK--G 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + + LPI+P+ + L R KQL IK + + I+ A D REG+ Sbjct: 57 FEKSSLPILPDPFLLTVRKQKIDAGYTADAGAQKQLKTIKYVVGLSDLIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL+ R+ R I++L +A+ + ++ L+ SE L ++A AR+RAD Sbjct: 117 LIFRYIYEYLEF----RKPFVRLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSRAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK-AHI 228 WL GIN ++A ++ A GV S+GRVQTP L LV R E ++F + +++++ H Sbjct: 173 WLVGINASQALSL----AQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQLQLTH- 227 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 + FT+I E D + + + A + R + A V+S K +E Sbjct: 228 -SRNFMLFTSI------SEKRWDNKRQAMD---ALRAIER-NAATAWVSSVEIKNSTEQP 276 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE--------- 339 PL F L+ LQ +A+ LSA L I Q LYE + I+YPR+ R + + Sbjct: 277 PLLFDLTGLQKQASTDLSLSAGETLSIAQSLYE-KQFISYPRTGSRSISADVWDEIPSLI 335 Query: 340 -HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTEN 398 R AIS L + +V + V HH ++PT R + L+ Sbjct: 336 KALGTRENFREAISTLKLGRLNKRIVS---------EAGVTDHHGLLPTERIPS-ALSGK 385 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCV-----IELDIAKGKFVAKARFLAEAGWRTLLGSK 453 E +YNLIA + L +AV C+ + L + F+ + E+GWR G K Sbjct: 386 ETAIYNLIAGRLL-----EAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWR---GVK 437 Query: 454 ERDEEND--GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 R E+ G LP + +GDEL ++ V+E+ T PP +T+A LLS M + QD Sbjct: 438 ARFLESGEPGQELPEIKRGDELKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQ 497 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDM 570 +KIL+A G+GT ATRA IIE LF R ++ ++G+ + T+ G ++ + + M Sbjct: 498 ERKILQAI-GIGTPATRAAIIETLFDRKYIQRQGKSLIPTEKGLMVYELVKDKRIADVAM 556 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 TA WE+ L +I K+ F + + + + TP Sbjct: 557 TAQWETELWKIENKEADAATFQKQMESYATSITKELLETP 596 >UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_CLOPH Length = 721 Score = 250 bits (639), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 193/700 (27%), Positives = 327/700 (46%), Gaps = 105/700 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+I+EKPS+A+ A L RK DG++E + +VTWC+GHL+ + P++YD +W+ Sbjct: 11 LYISEKPSVAQEFAKALKSNFRKSDGYMESEDS-IVTWCVGHLVTMSYPESYDPALKKWS 69 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +P +P++++ + PSV+KQ V+K L+ + +I D REG+ + ++D + Sbjct: 70 LQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIY-RLVDQMA 128 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 P+ +++ +R I+ + + R I + S++ L SA RA+ D+L GIN +R Sbjct: 129 KVPKNKEK-RRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSR-- 185 Query: 181 TILGRNAGY----------QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 +L GY ++VGRV T VLG+VVRR+ EI FV F+ V + T Sbjct: 186 -VLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLET 244 Query: 231 P---ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-------------- 273 D F A+ P +E + AE ++ ++G Sbjct: 245 SDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNS 304 Query: 274 ---------------AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQK 318 A + S K+E+++ PL F+L+ LQ E +K F +S L Q+ Sbjct: 305 YLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQE 364 Query: 319 LYETHKLITYPRSDCRYLPE-------EHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNR 371 LYE KL+TYPR+D R L ++ G A ++ A ++L + R Sbjct: 365 LYE-KKLVTYPRTDARVLSTAVSKEIYKNIKGLTA-LSQFQPFAEEVLALGSYKNIAKTR 422 Query: 372 CWDDKKVDAHHAIIPTAR--SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI 429 +DK++ H+AIIPT + + +L+ +VY I +++L F P AV++K I I Sbjct: 423 YVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKI 482 Query: 430 AKGKFVAKARFLAEAGWRTLLG---------------------------SKERDEEN--- 459 F + R L E G+ + G K DEE Sbjct: 483 DTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEE 542 Query: 460 ---DGTPLPVV---AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 D T V+ KG +L + E +T PP+ + +L+ AM + + D++L+ Sbjct: 543 KDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELR 602 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLT--KKGRYIHSTDAGKALFHSLPEMATRP--- 568 ++ + G+GT ATRA I+ L K +L+ KK + + G+ L + + ++ R Sbjct: 603 AQIKGS-GIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGE-LIYDVVNVSIRSLLN 660 Query: 569 -DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 ++TA WE LT +S+ +++ L G + ++ + K Sbjct: 661 AELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVK 700 >UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2MEK2_9PORP Length = 699 Score = 249 bits (636), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 190/639 (29%), Positives = 313/639 (48%), Gaps = 55/639 (8%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-VTWCIGHLLEQAQPDAYD-SRYARW 61 I EKPS+A IA VL H K +G++ N Q +TW GHL+ A P Y + YAR Sbjct: 7 IITEKPSVAMDIAKVLNVTH-KSEGYLY--NDQYKITWAYGHLVALADPQTYGFTSYAR- 62 Query: 62 NLADLPIVPEKWQLQPRPS-------------VTKQLNVIKRFLHEASEIVHAGDPDREG 108 +LP++P+ ++L R KQLNVIK+ + I+ A D REG Sbjct: 63 --EELPMLPKPFKLVVRQVKKKDGKGYEEDDFARKQLNVIKQCFDSSERIIVATDAGREG 120 Query: 109 QLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA 168 +L+ + YL + + R ++ + QA+ A +L+ + L ++ AR+ A Sbjct: 121 ELIFRYIYYYLGCS----KPFDRLWLSSMTDQAIRDAFTKLKEGQLYDNLYLAGKARSEA 176 Query: 169 DWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 DWL G+N +RA TI + G LS+GRVQTP L ++ R +NFV F+++ A Sbjct: 177 DWLVGMNASRALTIASNGS---GGLSLGRVQTPTLCMICDRYLSNKNFVKSPFWKINAQ- 232 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI-VTSYNDKRESES 287 V + FT + EP + ++ LA+ + +S ++ VT K S Sbjct: 233 VKSGETTFTV-----SSPEP-------ITNKGLADSKLYAVSNLTSLTVTKAERKSTSSQ 280 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL + L+ LQ EA K+ G +A+ L+I Q LYE K+ TYPR+ RY+P++ + + Sbjct: 281 PPLLYDLTTLQKEANKQ-GFTAEQTLNIAQSLYE-KKVTTYPRTGSRYIPKDVYDTMSYL 338 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 + + + Q ++ + DD K+ HHAII T ++ +LTE+EA +Y +IA Sbjct: 339 LRQLPYQEYQIYAQGLIVAGLNPHSVDDSKITDHHAIITTGETA--DLTEDEAIIYKMIA 396 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG--KFVAKARFLAEAGWRTLLGSKERDEENDG---T 462 + L P + K ++ L ++ G + V + + GWR + G D ++D Sbjct: 397 MRMLEAVSPAS--NKELLSLTLSGGGEELVTTLSCIKKKGWRVVKGETTEDPDSDEVSLN 454 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP +A G EL + + E +T+P +T+ATLL AM + ++DK+ ++ ++ GL Sbjct: 455 SLPSIADGMELSLVQATLKEGETKPKPIYTEATLLGAMERAGKEIEDKEAREAMQDV-GL 513 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQI 581 GT ATRA IIE L ++ + ++ + T+ G +++ + + ++T WE L +I Sbjct: 514 GTPATRASIIEKLLRQNYAVRQKNQLIPTERGLVVYNLVKSRLIGNAELTGQWEKSLAEI 573 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAP 620 F + Q+ D+ T V + P Sbjct: 574 EAGNLPPTTFNSQIEDYTKQITDELLSTSVSLGTNYICP 612 >UniRef50_C8L8E9 DNA topoisomerase n=7 Tax=Staphylococcus aureus RepID=C8L8E9_STAAU Length = 700 Score = 248 bits (634), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 184/627 (29%), Positives = 310/627 (49%), Gaps = 41/627 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-----VTWCIGHLLEQAQPDAYDSR 57 L + EKPS A ++ V K +K +G++E + Q+ +TW +GHL+E +P YD + Sbjct: 4 LILCEKPSQAMDLSTVFAK-KKKQNGYMEISDEQLNVSGFLTWAVGHLVELKEPQEYDEK 62 Query: 58 YARWNLADLPIVPEK--WQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVD 113 Y N + PI+ EK +Q + Q N IK+ E E++ A DP REG+ + Sbjct: 63 YK--NFSTYPILLEKDDFQFKVSDKTKDQFNNIKKIFKENKIDEVIIATDPAREGENIAY 120 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 ++L+ QL + ++R + ++ +A + + AR +DWL G Sbjct: 121 KILN--QLKVTDKVTIKRLWLTSKVESSIRKAFKNILPKEKTYGFYKEGRARELSDWLVG 178 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 IN++R +T + R G GV+ +GRV +P L +V R+ I+ F K F++V A I Sbjct: 179 INLSRHFTKISRELGNDGVIHIGRVSSPTLNMVYNRENNIKGFKGKKFYKVSATINKDEQ 238 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 E T + ++ +DE LH L E+ + ++ Q +VT + P + Sbjct: 239 EVKTELKNKFDS----EDE----LHEFLFENDITDLT-QKGLVTDIEKEIGYTMPPKFYD 289 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LSALQ + ++ +SA+ L+I Q LYE KLITYPR+D RY+ E+ + ++ I Sbjct: 290 LSALQEDMNDKYKISAKRTLEIAQTLYE-KKLITYPRTDSRYITEDE---KEMLLENID- 344 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLM 412 + ++ + + N + K++ H+AI+ T + ++L E E VY I + M Sbjct: 345 YLKEITKINLNNELTNNSLINPSKIEDHYAILITGNDFNKVDLKEEEINVYKSILQNVAM 404 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F + IE+ + K F K + + + G++ LL ++ EE +P K +E Sbjct: 405 NFMDKEQYETTTIEIAVKKLMFEVKGKIIQDNGFKALLNKQKTSEE----TIPNFEKNEE 460 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + E +++E++T PP+ +T+ TLL AM ++D+ LK L+ GLGT ATRA II Sbjct: 461 VDIE-LDLLEKETTPPKRYTEKTLLKAMANPIETLEDEGLKSTLKEVKGLGTPATRADII 519 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQCRYQD 590 E L K ++ + I+ T G L L E + ++PD+T WE L IS+ + Sbjct: 520 ENLKKNKYIQVQKNKIYITKNG-ILACLLLEGHLLSKPDLTGQWEKYLNGISKGEKDDDS 578 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGI 617 F + T+ ++I + V+ I Sbjct: 579 F----INTINEMIKKTINEEVKNKESI 601 >UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteobacterium BAL199 RepID=A8TWU8_9PROT Length = 894 Score = 248 bits (632), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 199/642 (30%), Positives = 308/642 (47%), Gaps = 56/642 (8%) Query: 43 GHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSV----TKQLNVIKRFLHEASEI 98 GHLL+ +P+ + RW+ + + PE RP+V +L I+ LH A + Sbjct: 33 GHLLDLQEPEDVVPEWKRWS--SVLLRPEGL-YGTRPAVGGNKAAKLKAIREALHTARRV 89 Query: 99 VHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPL 158 A D DREGQL+ E+L++ R +V R + + Q + + DR R N+++ L Sbjct: 90 WLATDCDREGQLIGQEILEHCGF----RGEVLRVMFTAQDTQTIRDSFDRARPNADYAGL 145 Query: 159 CVSALARARADWLYGINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFV 217 +A+AR +AD +Y +++TR T+ LG+ G + V+ VGRV+TP L +V RR+ EI FV Sbjct: 146 YAAAVARRQADQIYNLSLTRTATVTLGK--GARSVVGVGRVKTPTLAIVCRRELEIRQFV 203 Query: 218 AKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIV 276 +FE+ A A + FT P E R+L R AE ++N + + Sbjct: 204 PVAYFEITATATVAAGD-FTMRHAP----------EKRILRRADAESILNAARDFEGPLA 252 Query: 277 TSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLY--ETHKLITYPRSDCR 334 DKR+ P L +LQ A RFG SA L+I Q+LY + K+ITYPR++ R Sbjct: 253 VRVEDKRQGP--PKLHDLPSLQKLCASRFGWSAARTLEIAQELYDGQNKKIITYPRAEVR 310 Query: 335 YLPEEHFAGRHAVMNAISVH---APDLLPQPVVDPDIRNRCWDDKKVD--AHHAIIPTAR 389 YLPE ++ + V A +P P V + + DK ++ +HHA+IP Sbjct: 311 YLPESLIPDVPKIVAGLQVGKSCATIAVPTPPVIRKGAHGAFHDKGLEGASHHAVIPNVN 370 Query: 390 SSA------INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAE 443 + A L+ +E K+++++AR YL PD +R+ LD+ F A R + Sbjct: 371 TVAGLREVWPRLSLDEKKLFDVVARAYLAAMMPDFRYRQTTATLDVRGVPFKASGRQPID 430 Query: 444 AGWRTLLGSKERDEENDGTP--LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMT 501 GWR + +E G LP + G+ + +++T+PP + + TL+ AM Sbjct: 431 LGWRAAFPEWQPADEKSGDAQLLPPILDGETARLRDAAIEDKETRPPPRYNEGTLIEAMQ 490 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 RFV+D+ L+ LR G+GT ATRA II L ++ FL +G+ I TD G ALF L Sbjct: 491 NAWRFVEDEALRNRLREAKGIGTPATRAEIIAGLKRQQFLVAQGKAIVPTDTGLALFDVL 550 Query: 562 ----PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ-AKRTPVRQFRG 616 P + P +TA E +L + + D + + G ++I TP+ Sbjct: 551 RQADPALVD-PGVTAQLECLLDDVVVGKQAMIDAIDAVCGVAQRIIGNLTSGTPIVSAAL 609 Query: 617 IVAPGSGGSADKKKAAPRKRSAKK-------SPPADEVGSGA 651 + G D+ A KR A+ +PPA S A Sbjct: 610 LGGRSVGPRTDRPPTAAMKRFAESIARRKRIAPPAGYATSSA 651 >UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TFR0_HELMI Length = 781 Score = 244 bits (624), Expect = 7e-63, Method: Compositional matrix adjust. Identities = 193/655 (29%), Positives = 314/655 (47%), Gaps = 84/655 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS A AIA+ + ++K G++E + +TW +GHL++ A+P+ Y S RW Sbjct: 4 LIIAEKPSAAEAIAEAVAGTYQKKRGYLESPDF-YITWAVGHLVQLAEPEDYRSSLKRWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 DLPI+P+ +QL+P QL I ++ +++A D REG+L+ ++ YL+L Sbjct: 63 FGDLPIIPD-FQLRPVKKTEGQLKTIAGLAKKSRALINACDAAREGELIFRYIVAYLRL- 120 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R L +A+ A+ L+ + L SA R+ DWL GIN TRA+T Sbjct: 121 --EEMPAWRLWTASLTAEAIRAAMADLKPLDRYDNLFKSARCRSEGDWLIGINATRAFTT 178 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + +L++GRVQTPVL ++ + FV + ++EV A + + +W Sbjct: 179 R-----FGELLTLGRVQTPVLAMICENRRRRDAFVPETYWEVWARFRGEGCD-YRGLWLR 232 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + E RL + AE + + G+ V ++K E P + L+ LQ E Sbjct: 233 EKG------EAHRLNEKGKAEAIAAAVDGRNGEVRQVDEKESRELPPRLYDLTTLQRECN 286 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQP 362 + FG SA L I Q+LY++ K ITYPR++ R++ + A V++ ++ H P Sbjct: 287 RLFGFSANKTLKIAQELYDS-KFITYPRTNSRFVDKHGLALLRRVVSGLASH-------P 338 Query: 363 VVDPDI------------RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 V P + RN C + V+ HHA++PT L ++ KVY+ I R+ Sbjct: 339 VYGPFVAQGNPQLVHERNRNIC-RPEAVEDHHALLPTTLVPT-GLVGDKWKVYDRIVRRV 396 Query: 411 LMQFCPDAVFRKCVI--------------------------ELDIAKGK---------FV 435 L + A +R+ V+ LD A K F Sbjct: 397 LAHYYLPARYRERVVLTVVPFERITGKATDLPVGDLGMATAVLDSAHSKEADDLGGAVFR 456 Query: 436 AKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDAT 495 + + + + GW+ + G +E + P G + C EV+E+QT+PP+ +T+ + Sbjct: 457 SAEKTIIDPGWKVVDGGWTPPKEQERFP---ERAGLAVRCAGAEVLEKQTEPPKAYTEGS 513 Query: 496 LLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGK 555 LL+AM + + D++L++I++ GLGT ATRA IE L + G++ +GR I T G Sbjct: 514 LLAAMETAGKQLDDEELREIMKDA-GLGTPATRAATIERLKEVGYIELQGRQIEPTPKGM 572 Query: 556 ALFHSLPEMATRP-----DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 AL SL E + P +MT WE L +I+ + +F + + L+ Q Sbjct: 573 ALI-SLVEKSEIPLLLSAEMTGRWEKFLNEIARGNAQPLEFNRRVSDLAVYLVKQ 626 >UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4ZCE3_EUBR3 Length = 1273 Score = 243 bits (621), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 182/655 (27%), Positives = 308/655 (47%), Gaps = 72/655 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A VL R DG+IE G V++WC+GHL+ P++YD +Y +W Sbjct: 5 LIITEKPSVAQEFAKVLRVSGRN-DGYIENGE-YVISWCVGHLVGLVYPESYDMKYKKWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +P++++ SV KQ N++ L + + AGD +EGQ + + + ++ Sbjct: 63 LEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + + R I+ + + R I + S + L S + R D+ GIN +R Sbjct: 123 V--REGMEELRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVM 180 Query: 181 TI-----LGRNAGYQG--VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 ++ L AG + ++VGRV T VLG+VV R+ EI NF F+ V D Sbjct: 181 SVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFT---D 237 Query: 234 ERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 A W+ E ++ +E A ++ ++G+ A + S + AP Sbjct: 238 AGVEAEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAP 297 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE------HFAG 343 L F+L+ LQ E +K+F +S L + Q LYE KL TYPR+D R L G Sbjct: 298 LLFNLAELQAECSKKFKISPDETLQVAQDLYE-KKLTTYPRTDARVLSSAVAKEIGKNIG 356 Query: 344 RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKV 402 R + ++ + + + DD KV H+AIIPT + + ++ LT + V Sbjct: 357 RLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAV 416 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRT-------------- 448 + LI R++L F P A + + +D+ K F A ++ L G+ Sbjct: 417 FELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESN 476 Query: 449 --LLG-------SKERDEENDGTPLPVVAK-------------GDELLCEKGEVVERQTQ 486 +LG S + + +G+ +V GDE+ C+ + +T Sbjct: 477 ARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTS 536 Query: 487 PPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF--LTKK 544 PP+ +T +++ AM + ++D++L++ ++ + G+GT ATRA II+ L + G+ L KK Sbjct: 537 PPKRYTSGSMVLAMENAGQLIEDEELREQIKGS-GIGTSATRAEIIQKLVRIGYLNLNKK 595 Query: 545 GRYIHSTDAGKALFH----SLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 + + G+ +F ++P + P MTA+WE L I+ + ++ L Sbjct: 596 TQILTPESLGEMVFEVVYMTVPALLN-PKMTANWEKGLDGITRGTVDFWEYRGKL 649 >UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU1_CLOCL Length = 730 Score = 242 bits (618), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 185/645 (28%), Positives = 313/645 (48%), Gaps = 47/645 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IA+ L RK DG++E GNG +TW GHLL+ YD + A+W Sbjct: 3 KVIIAEKPSVAKNIAEALKSNIRK-DGYLE-GNGYYITWAFGHLLQLYDAKDYDEKMAKW 60 Query: 62 NLADLPIVPEKWQL----------QPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQ 109 + + P +P+ ++ +P KQL +I+ + ++ ++ A D DREGQ Sbjct: 61 KMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ D + YL++ ++ V R L N+ V + +++++ N+E L + ++R AD Sbjct: 121 IIGDIITGYLKV----KKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWAD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W GIN+T T L G L++GRV P L ++ RD+EI NFV ++F++ A Sbjct: 177 WTIGINLTSVAT-LKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T + + + E + + + R + + ++ G ++ +++ E P Sbjct: 236 TSDNIEYEGAYIEKEQEKEQE----KFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPP 291 Query: 290 LPFSLSALQIEAAKRF-GLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA-V 347 F+LS LQ ++ G ++ VL + Q LYE K ITYPR+ L EE A R A V Sbjct: 292 YLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYE-KKYITYPRTASVVL-EESLADRAAKV 349 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 +N + P Q V R +D+ KV++H AIIPT L+ +E KVY+ I Sbjct: 350 LNTLKKSLP---FQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPK-TLSGDEEKVYSAIK 405 Query: 408 RQYLMQFCPDAVFRKCVIELDIAK----GKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +++ QF P A + I I G F++K + GW+ + E+ E D T Sbjct: 406 NRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKV----EKIESKD-TI 460 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT---D 520 LP V DE+ K +V T+PP+ T+ TLL M + ++ +++ A Sbjct: 461 LPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGF 520 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLT 579 +GT ATRA I+ L G++ +G+ + ++ G L + P + + T E L Sbjct: 521 SIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLA 580 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQA---KRTPVRQFRGIVAPG 621 + + + +DF++ + I+Q K + Q+ G + G Sbjct: 581 DMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKG 625 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 240 bits (613), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 189/645 (29%), Positives = 297/645 (46%), Gaps = 55/645 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA L R D ++E + +++ GHL+E S + Sbjct: 5 LIIAEKPSVAKDIALALGGFGRV-DNWLESPDA-IISSAQGHLVEVFSTLMDTSGK---D 59 Query: 63 LADLPIVPEKWQLQ-----PRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEV 115 L LP++P + L+ RP + QL KR + + +V+A D REG+L+ + Sbjct: 60 LQSLPVIPPSFDLRVIDGANRPQLFAQL---KRLMSRQDVDAVVNACDAGREGELIFRLI 116 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + ++R + P+A+ + ++ ++F L +A R D+L GIN Sbjct: 117 YKLAGCT----KPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSDAAFCRTEGDYLVGIN 172 Query: 176 MTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 +R T + R SVGRVQTP LV R+ I F AKD++EV H A Sbjct: 173 GSRGVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAKDYWEVHGHFGVAAGN 232 Query: 235 RFTAIWQPSEACEPYQDEEG-------------RLLHRPLAEHVVNRISGQPAIVTSYND 281 + P+ Q E G R + A+ +V + SG Sbjct: 233 YVGKWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIVAKCSGTNPTDVREES 292 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K ++ +P + L++LQ EA ++ GLS++ LDI Q LYE HK+ TYPR+D +LPE++ Sbjct: 293 KPTAKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVTTYPRTDSSFLPEDYV 352 Query: 342 AGRHAVMNAI-----SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT 396 A + + ++ HA ++ V PD + +D+ K+ H AIIPT + LT Sbjct: 353 AKAQSTIESLVGTTYEPHAKRVIDGGWVKPD--KKIFDNGKISDHFAIIPTGKRPE-GLT 409 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 E KVY++I R++L F P A ++ +A F + R L GW + G+ D Sbjct: 410 PEEGKVYDMIVRRFLAVFHPAAQYQVTTRITVVAGEHFKSSGRVLISEGWMAVYGADVDD 469 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 E+ L G+ + + E+ +T+PP +T+ TLL+AM +FV D +L + Sbjct: 470 EDKKTPALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLLAAMESAGKFVDDDELADAM 529 Query: 517 RATDGLGTEATRAGIIELLF---------KRGFLTKKGRYIHSTDAGKALFHSLP----E 563 + GLGT ATRA IIE L K +L + G+ + T +L L E Sbjct: 530 KER-GLGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLVPTPKLISLIEFLRNNGIE 588 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 + P +T WE L I + R F + Q+ID ++ Sbjct: 589 LLASPKLTGEWEHKLRLIERGEYRRDAFNNEIGDLTRQIIDAIRK 633 >UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantarius subsp. infantarius ATCC BAA-102 RepID=B1SE14_9STRE Length = 578 Score = 239 bits (609), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 181/621 (29%), Positives = 304/621 (48%), Gaps = 62/621 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHR-KGDGFIECG--NGQV-VTWCIGHLLEQAQPDAYDSRY 58 L +AEKP A+ A+ L P KG ++ N +V V +GHL+E+ P S + Sbjct: 4 LLLAEKPDQAKKYANALGNPKSDKGVWHVQSSVLNAEVTVAPAVGHLVERINPY---SNF 60 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W + +LP +PE + +P+ K+ N IK+ + E I+ DPDREG+ + + Sbjct: 61 ENWEMTNLPALPEGFSYEPKKDTIKRFNAIKKAVKEVDAIIIGTDPDREGEAIAYRI--- 117 Query: 119 LQLAPEKRQQVQ-RCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+L P ++++ R N L + +E+A L++ + V A AR ADWL G N++ Sbjct: 118 LELIPGALKKIKYRLWANSLTKKGLEQAYSSLKNPKDSVDYFHEADARGDADWLVGFNLS 177 Query: 178 RAYTILGRNAGY----QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 TI + GY + +SVGRVQTP++ LVVR DE IENF ++++K ++ P Sbjct: 178 PFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQLK--LIDP-- 233 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 EA + + + + + AE ++ +++ A+V + + +++ AP ++ Sbjct: 234 ----------EAKVTFGN-DIKYQSKSEAEQILQQLTNT-AVVKTVTSEEKAQEAPKLYN 281 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L+ Q E +K + A ++ Q LY+ L +YPR+D + + FA + Sbjct: 282 LTNFQSEMSKLYHFDATKTKELVQSLYQKGYL-SYPRTDSTLITTKEFAYLVDHIEKYQK 340 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLM 412 L P P R +DKKV H+AIIPT +N L+++E +Y + + L+ Sbjct: 341 AINKQLETPNRSP--RKSYVNDKKVVEHYAIIPTETIPDLNELSDDEKLIYQKVVFRTLL 398 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F PD ++ + LD +F A + GWR K+ D+E LP +G + Sbjct: 399 MFTPDYRYQSTSVILDNHGLEFKATGAVTKDKGWRNYFSVKKEDKE-----LPHYQEGQK 453 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + E +V+E T+PP T+ L LKK+L LGT ATR G+I Sbjct: 454 ITVE-CKVLEEVTKPPTRITEQIL---------------LKKLLPKYH-LGTSATRDGMI 496 Query: 533 ELLFKRGFLTKKGRY--IHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 +L+ +G++TK + T+ GK L H L ++ T P+ T WE VL QI + + + Sbjct: 497 DLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQ 556 Query: 588 YQDFMQPLVGTLYQLIDQAKR 608 + F+ + + + I++ K+ Sbjct: 557 KEAFVDKIKWAITKQIEKGKQ 577 >UniRef50_C3RPW1 DNA topoisomerase n=1 Tax=Mollicutes bacterium D7 RepID=C3RPW1_9MOLU Length = 795 Score = 236 bits (601), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 179/627 (28%), Positives = 301/627 (48%), Gaps = 46/627 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWC--IGHLLEQAQPDAYDSRY 58 M+L IAEKP++++ + D +PH K G G+ T+C +GHL A P+ + Y Sbjct: 1 MKLVIAEKPNVSKQLRDAF-EPHAKYGGAPGYFIGEKYTFCCALGHLFTFAMPEEINDNY 59 Query: 59 ARWNLADLPI-VPEKWQLQPRPSVTKQL-NVIKRFLHEAS--EIVHAGDPDREGQLLVDE 114 R+ L DLP+ +P L+ VTKQ +V+K+ + EI+ A DPDREGQ + + Sbjct: 60 KRYALEDLPLNLPNDIPLKLTNDVTKQYYSVLKKLFKTGNFDEIIVATDPDREGQSIYER 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + + P+ + R I++ P + +A++ + N + L ++ RA D+L G+ Sbjct: 120 IKSQTRNFPKVPES--RIWISEWTPSGLIKAMNNKKPNDNYRGLKAASECRAIEDYLIGM 177 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RA T+ + G V+S+G QTP L ++V R+ EI NF A+D+ +V E Sbjct: 178 NGSRAMTV--KFGGANNVISIGSTQTPTLYMIVSREREITNFKAEDYGVPFIELVNDKGE 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 T E + + L +H Q IV +R S+ LP + Sbjct: 236 LLTLKHTSKRHLSLL---EAQTTQKKLLQH-------QGTIVNIEEKRRTSKPMKLP-NA 284 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-SV 353 + +Q E K++G +A +I Q LY+ L TYP + R + + + +N I ++ Sbjct: 285 TDIQKEMNKKYGFTADKTSNILQTLYQDKHLTTYPGTKAREISK---SSATLSLNTIKNL 341 Query: 354 HAPDLLPQPV-----VDPDIRNRCWDDKKVDAHHAIIPT----ARSSAINLTENEAKVYN 404 +++P+ + +I C ++ + AH AI P + +LT++E KVY+ Sbjct: 342 LKNNVMPKETEKILENNWEIAKHCIANEGL-AHEAITPVFGQINQKDIDSLTQDERKVYD 400 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 I ++++ F P+AVF +I I F+AK + + G++ ++G E + L Sbjct: 401 EIVKRFVQAFFPEAVFSDTIITTTIDSENFIAKGSIIIQKGYKEIMGVGEDN------LL 454 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL--RATDGL 522 P G + K + E+QT PP +T +TLL AM +RFV DK KIL + +GL Sbjct: 455 PAFVNGKKYPISKVGIEEKQTTPPPRYTTSTLLEAMENASRFVDDKHYAKILSSKEVNGL 514 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT--RPDMTAHWESVLTQ 580 GT+ TR+ I+ L +R + KG+ I+ T LF LP P A E L Sbjct: 515 GTDRTRSDILNKLLQRNYYEFKGKTIYPTQKAIDLFKVLPSSGELDSPIHKAKMEEKLAL 574 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + + ++++Q + + + K Sbjct: 575 VELGKLSKKEYLQEVYQDINSFVQAVK 601 >UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyticus ATCC 51172 RepID=C2BD67_9FIRM Length = 683 Score = 232 bits (592), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 184/613 (30%), Positives = 295/613 (48%), Gaps = 55/613 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A++IA+VL +++ DG+IE G +VTW GHL+ P++Y+ Sbjct: 5 MKLIIAEKPSVAKSIANVLG-CNQQQDGYIE-GRSCIVTWTGGHLVTLDDPESYNPSCNH 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDY 118 WN ADLPI+P ++ + S + Q V+K +++ +V A D REG+L+ V D Sbjct: 63 WNKADLPILPRPFKTKLISSKSHQYKVVKNLINDKRIESVVCATDAGREGELIFRLVYDK 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ R I + A+ ++ + + L SA AR ADWL GIN+TR Sbjct: 123 IGT----KKTFTRMWIQSMEDPALLDEFNKAKDGHAYDNLSESAKARQEADWLVGINLTR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +I ++GRVQTP L L+ R EE ENF + + ++A I Sbjct: 179 LVSIENNKK-----FTIGRVQTPTLNLINARCEEKENFKPQKYNTIQADISLDG----KV 229 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 I +E E Q+ ++ + IS + ++ AP + L+ LQ Sbjct: 230 ITFETERIET-QESNCKMSSMSSELEIEEVIS-----------EEKTTKAPKLYDLTNLQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A K+FGLSA+ LDI Q LYE K I+YPR+D Y+ + +V I H Sbjct: 278 RAANKKFGLSAKQTLDIAQSLYEA-KYISYPRTDSEYITSDMV---ESVRQLIGSH---- 329 Query: 359 LPQPVVDPDIRN---RCWDDKKVDAHHAIIPTARS-----SAINLTENEAKVYNLIARQY 410 VD D+ + + ++KKV H A++PT S NL +N +Y LI Q Sbjct: 330 -----VDSDMFDNVEKIANNKKVSDHTALLPTIYSIDKKDEINNLDKNHINIYTLIYMQL 384 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L + + + I+ + + G++ L SK+ +++ L + +G Sbjct: 385 LKAVSKNYRYMQTKIKAISGDIDLYTVGKVDIDQGFKK-LESKDNAAKSE-KDLSGLEEG 442 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 ++++ T+PP ++ D +LL AM + +K L +I R GLGT ATRA Sbjct: 443 MSYPITDTRLMDKTTKPPAYYNDDSLLKAMKTAGSGLYEKGL-EIERT--GLGTTATRAD 499 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 IIE L K G++ + + I T+ GK L PE ++T +WE+ L +ISE + Sbjct: 500 IIEGLIKNGYIERSKKDIVITELGKQLLSVAPEKLKEVELTVNWENELAKISEGEKDKNS 559 Query: 591 FMQPLVGTLYQLI 603 F+ + L +++ Sbjct: 560 FILKIENYLKEIV 572 >UniRef50_B7U5A8 DNA topoisomerase n=2 Tax=Bacillus RepID=B7U5A8_BACSU Length = 776 Score = 232 bits (591), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 174/623 (27%), Positives = 301/623 (48%), Gaps = 62/623 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 LF+ EKP+ A+ A L K +G+ +G+V T+ GHL+E P+ + + + Sbjct: 4 LFVCEKPNQAQDYAAALSGNFEKKNGYFLGEDGKVFTYAFGHLVELKGPEQLNWKS---D 60 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L LP + +L + KQ VI + +A ++ + D REG+ + ++ L Sbjct: 61 LDTLPYFEKNMELALIENKKKQYFVIVDLMKKAETVIISTDSGREGEHIFRKIYKLSGL- 119 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + ++R + D +++A +LR SE+ L + R AD+L G+N T T Sbjct: 120 ---NKPLKRLWVKDNTESGIKKAYSQLRDGSEYEGLAKAGQLRDEADFLVGVNATILAT- 175 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R + + +S+GRVQTP L ++V+RD IENF + F + A + F + Sbjct: 176 --RLSSSRTPISLGRVQTPTLSMIVKRDYTIENFKKVEHFTLSASVKKQGIGNFELLL-- 231 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E+ + L + AE ++ + + + +++K E E F L++LQIE Sbjct: 232 ---------EKDQQLTKADAESILTALGNRVGL--RFDEKIEKEKPKHLFDLTSLQIEMN 280 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP-- 360 K+ G SA+ LDI Q LYE HK++TYPR+ +++ A + P LL Sbjct: 281 KKVGWSAKKTLDILQGLYEKHKVVTYPRTSSKFV-------------ASTEEFPALLEQH 327 Query: 361 --QPVVDPDIRNRCWDDK------KVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 QP++ + N+ +K KV H AII T + I L + E +Y++I ++++ Sbjct: 328 KDQPLIAHILENKYEIEKTFVNPGKVTDHEAIIITKQKPKI-LGKEEELLYDVIFKRFVA 386 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P AV++K E + F + + L E GWR++ ++ + P++ + Sbjct: 387 AFYPPAVYQKTSAEFSDGEHVFKSNEKVLIEKGWRSIYDAEIQK--------PILKDINL 438 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + E+ ++T+PP+ + + TLL+ M +FV + KK+++ G+GT ATRA II Sbjct: 439 DDIDDYELKRKETKPPKRYDEGTLLNDMENAHKFVSEAKDKKLIKEA-GIGTSATRADII 497 Query: 533 ELLFKRGFL----TKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQC 586 E+L KR F+ K + ST G+++ +PE + P MTA +ES+L + E Sbjct: 498 EVLCKRNFVERQTVKDKEVLVSTPLGRSVISMMPEDFLLYSPKMTAIFESMLGDVEENNL 557 Query: 587 RYQDFMQPLVGTLYQLIDQAKRT 609 +F L +Y + Q + Sbjct: 558 SPSEFYAELENLVYGIAKQIREN 580 >UniRef50_B4U9A2 DNA topoisomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U9A2_HYDS0 Length = 775 Score = 230 bits (586), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 194/693 (27%), Positives = 317/693 (45%), Gaps = 122/693 (17%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKG---DGFIECGNGQV-VTWCIGHLLEQAQPDAYDSR 57 RL +AEKPS+AR IA L K K G+ EC + +TW IGHL+E D Sbjct: 3 RLILAEKPSVARDIASALCKSLNKDASKKGYFECEEKNLYITWAIGHLVE------IDDE 56 Query: 58 YA--RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 A +W+L LPI+PE ++ + + Q VI + L E E+V A D REG+L+ + Sbjct: 57 IAPRKWSLETLPILPETFKYKVIDKTSNQFKVISKLLKEVDEVVIATDAGREGELIARLI 116 Query: 116 LDYLQLAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L + + V+R +D L + + R ++ L+ S F L SALAR+ ADW+ GI Sbjct: 117 L----MLNHFKGSVKRFWTSDALTKEVIIREMENLKDASLFDSLYYSALARSHADWIVGI 172 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N+TR T+ AG GV SVGRVQTP L L+V R +E ++F+ K+++ +KA + + D+ Sbjct: 173 NLTRLMTV---KAG-GGVWSVGRVQTPTLKLIVDRYKEFKDFIPKEYYVIKA-VFSACDD 227 Query: 235 RFTAIWQPSEAC---EPYQDEEGRLLHRPLAEHVVNRISGQP------------------ 273 I + + Q++ + L L E + +G P Sbjct: 228 CIDTISKSYVGLLVLDKAQEKTYKTLKDALEEEESEKTAGAPKSKYFTPLLKESKNQIME 287 Query: 274 -------AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLI 326 IV + E+ PL SL++LQ EA + +G S+ L+I QKLYE++K + Sbjct: 288 KLEKVKEGIVKDVKITKRKENPPLLHSLTSLQREANRIYGYSSMRTLNIAQKLYESYKCL 347 Query: 327 TYPRSDCRYLPEEHFAG---RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHA 383 +YPR+D YL E+ ++ + + + + L + + + R +D K+ HHA Sbjct: 348 SYPRTDSNYLGEDQETKNLVKNLLKKLVDKNIYEFLSKNI--NKVGKRVFDSSKLTDHHA 405 Query: 384 IIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARF--L 441 +IP + + E +YNL+ R+++ F + I+ + + F++ L Sbjct: 406 LIPFGPIPE-DASNEEKNIYNLVFRRFVGAFMEPYEYAIITIKTMLGEFTFISNINIETL 464 Query: 442 AEAGW-RTLLG-------------------------------------SKERDEEN---- 459 E + +T L S + +E N Sbjct: 465 TEEEYQKTYLSLYRPYKLEIKESLSEDEDIEPNNIERYQRVSELRNRRSHQGEERNAYST 524 Query: 460 -DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 D + + D++ E +++ T+PP +T+ TLL M + Sbjct: 525 LDFDYIKSLKPDDKVYKRSLEALQKFTKPPALYTEGTLLKVMEKL--------------- 569 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESV 577 GLGT ATRA IIE L +R ++++ + + T G+ L SL + ++P+MT WE Sbjct: 570 --GLGTPATRASIIETLLERKYISRVDKSLLPTLKGEELIKSLRDSDVSKPEMTTTWEEE 627 Query: 578 LTQI-SEKQCR--YQDFMQPLVGTLYQLIDQAK 607 L +I E++ + Y FM + + ID+ K Sbjct: 628 LERIYKERKSKEGYIRFMHNIKEFVSDNIDRLK 660 >UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus group RepID=C2UN45_BACCE Length = 756 Score = 226 bits (576), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 176/644 (27%), Positives = 301/644 (46%), Gaps = 56/644 (8%) Query: 5 IAEKPSLARAIADVLPKPHRKGDGFIE---CG---NGQVVTWCIGHLLEQAQPDAYDSRY 58 +AEKP +A+ I PK ++K D + E C +G V +C+GHLL + Sbjct: 1 MAEKPDVAKKIVAAFPK-YKKHDLYYEIMPCNEFPDGAYVAYCMGHLLTFDEEKM--GTN 57 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVL 116 W+L+ LPI+P+ + +P K + IK+ ++ + ++ D REG + E++ Sbjct: 58 TPWSLSGLPIMPKSYIYKPIKGREKHVRTIKKLANDPKVTMFINCCDSAREGMKIFTEII 117 Query: 117 DYLQLAPEKRQQVQRCL-INDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 Y+ R +CL I+ L P ++++ + L L SA ARA AD+L GIN Sbjct: 118 KYVT----NRNLPTKCLWISSLTPASIKKGMQELVPYKSKENLYHSAYARAIADFLVGIN 173 Query: 176 MTRAYTIL---------GRNAGYQG----VLSVGRVQTPVLGLVVRRDEEIENFVAKDFF 222 ++R+ ++ N G V S+GR Q+P L LV R ++IE V + F+ Sbjct: 174 LSRSVSLRMQSEFASRNAENGDLNGLKREVFSIGRCQSPTLRLVYDRIKQIEAHVPEPFW 233 Query: 223 EVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 + I + +T W ++++ R E + R+ +PAI+ + Sbjct: 234 TLSG-IFEIDGKEYTGRW--------FKEDNNRFDSEEEIEDLSIRLVEEPAIIKEIKKE 284 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 R++ P F L+ LQ A K F + + L + LY L++YPR+D Y+ Sbjct: 285 RKAFKPPQFFDLTRLQSTANKLFKMDPKETLHHAESLY-LAGLLSYPRADNPYITAAEAP 343 Query: 343 GRHAVMNAI--SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENE 399 V+ + + LP P+ D+ +R ++KKV HH II + L E Sbjct: 344 ILSTVLEKLKYTESYSKYLPAPIRSTDLSSRYINEKKVSDHHGIIVLDVPKDFSKLNPGE 403 Query: 400 AKVYNLIARQYLMQFCPDAVFR-KCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 +Y+L+ ++ + DA++ +I + F+ K + GW+ L ++ EE Sbjct: 404 KAIYDLVVKRVIAAHHEDALYDFTSIITVVDETETFLTKGKQEVSLGWKMLYQKEQVSEE 463 Query: 459 NDG--------TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDK 510 D LP V +GD E+ + T+ P + T TL+ M +++K Sbjct: 464 KDDQEEENEEVAQLPDVKEGDTGTIVDTEISKGMTKAPPYLTPGTLVELMENCGSLMEEK 523 Query: 511 DLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRP 568 +++KIL+ T G+GT ATR GII L+ RG+L K + + G+ L +L + + P Sbjct: 524 EMQKILKKTSGIGTVATRDGIIHTLYDRGYLVNKNNKVLLLEKGRMLMDALGDKMIVCSP 583 Query: 569 DMTAHWESVLTQISEKQCRYQDFM---QPLVGTLYQLIDQAKRT 609 ++TA WE+VL IS+ + Y+ F+ + LV L I+Q ++ Sbjct: 584 ELTAKWENVLEAISDGRIDYKQFIGKAEKLVVKLLNDIEQISKS 627 >UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=B3DRF3_BIFLD Length = 719 Score = 226 bits (575), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 190/610 (31%), Positives = 291/610 (47%), Gaps = 61/610 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-YA 59 M+L IAEK S+A AIA L + DG ECG +VTW GHL++ A P+ Y R + Sbjct: 1 MKLVIAEKKSVATAIAQALCAAPVQRDGCYECGQ-LLVTWAQGHLIDLAMPEDYKDRDWR 59 Query: 60 RWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 +W+L LP+ P +W++ + I R + + +V+A DPDREG+ + Sbjct: 60 KWSLDTLPVDPSGHWQWKISEERGAGSRYRQIVRLIRRTDVDCLVNACDPDREGEAIFRR 119 Query: 115 VLDYL-QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 + D PE R + L +A++ A ++ SE+ L SA R++ADWL G Sbjct: 120 IADMEGSHKPE-----LRLWVASLEAEAIQAAWRAMKPESEYQGLAWSAEIRSKADWLIG 174 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 +N +RAY++L Y SVGRVQTP L ++ RD +I N F+ V A + Sbjct: 175 MNASRAYSLL-----YNARFSVGRVQTPTLAMIAERDRQIRNHKPVPFWTVIADM----- 224 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 W+ S E ++ +L AEH RI S N +R ++ P + Sbjct: 225 ----GGWRLS--SERIDSKDAAMLLCGQAEHGRFRI-------MSVNRRRVNDRPPRLYD 271 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L+ LQ + ++ +G++A L Q LYE KL TYPR+D RY+ + A++ + + Sbjct: 272 LTGLQKDMSRMYGMTAARTLQALQHLYEL-KLATYPRTDSRYITHDDLETLTALLESGRL 330 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI---NLTENEAKVYNLIARQY 410 + + + +DKKV H AI+PT + A L ++E KV I R+ Sbjct: 331 AQGFVTREGIPGHPRPELTVNDKKVAGHTAILPTMQLDAGKLEGLDDDERKVMTRIVRRM 390 Query: 411 LMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWR---TLLGSKERDEEN--- 459 D V V E+ D +F +++ AGW+ T G + DEE Sbjct: 391 WEAVGDDHVH--IVTEVKARLSDDTDREFSSRSDETVSAGWKAVETGHGPEPEDEETANP 448 Query: 460 ----DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 + P ++ G K V E +T+PP+ FT+ATLL+AM +R V+DK+LK Sbjct: 449 AGGRNVIPSNLMEGGVIRPVGKVTVEEGETRPPKPFTEATLLAAMEHASRCVEDKNLKAA 508 Query: 516 L----RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMT 571 L + G+GT ATRA IE L + + +KGR +H+T G+ L + +T Sbjct: 509 LDDDESHSGGIGTPATRADTIEKLVRSKLVERKGRQLHATTEGERLTDVVEPRLKDVLLT 568 Query: 572 AHWESVLTQI 581 A E L+ + Sbjct: 569 ARMEQALSDV 578 >UniRef50_C9BIP8 DNA topoisomerase n=1 Tax=Enterococcus faecium 1,141,733 RepID=C9BIP8_ENTFC Length = 529 Score = 224 bits (570), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 149/440 (33%), Positives = 230/440 (52%), Gaps = 32/440 (7%) Query: 101 AGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCV 160 A D DREG+ + +++ L+ R+ ++R IN L +++ L+ F Sbjct: 3 ATDSDREGEAIARLIIN---LSGNSRKTIKRLWINSLETSEIKKGFQNLKDGQAFYSTYK 59 Query: 161 SALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKD 220 A R ADWL GIN+TR YT+ + G +GV SVGRVQ P L L+ +R+EEI++FV+K Sbjct: 60 EAETRQIADWLVGINLTRLYTLYMQKNGMRGVFSVGRVQPPTLFLIYQRNEEIKHFVSKL 119 Query: 221 FFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYN 280 F+E+ A T ++ ++ ++ E + ++ +G L + + A VT+ Sbjct: 120 FYELYA-TFTHSNGKYKGKYK--ERFDTLENLDGFKETNQLEQ-------AENAEVTNVK 169 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 + + + AP FSLS LQ A KRF SA L I QKLYE K+++YPRSD Y+ Sbjct: 170 VEEKRQYAPKLFSLSDLQSFANKRFKYSADKTLSIAQKLYE-KKVLSYPRSDTNYIGSPE 228 Query: 341 F------AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI- 393 F R+ + + + P L + R D KV H+AIIPT + Sbjct: 229 FDYLKSNLSRYLELAGVGISEPQL--------NENKRYVDGSKVQEHYAIIPTKTLPKLS 280 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK 453 ++T++E +Y L+ + L F ++ + I+ I + F +K + E GW+ L + Sbjct: 281 DVTKDEKNIYLLVLYRTLAIFEKPYIYDETTIDTAINQVLFQSKGKTEKERGWKRLYKQE 340 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 E+D+ D LP V D + E E +TQPP ++T+ TLL+ M + R + DKD K Sbjct: 341 EKDK--DDPLLPEVTVNDSVAFAL-ETKEGKTQPPNYYTEGTLLTVMKHVGRAMDDKDSK 397 Query: 514 KILRATDGLGTEATRAGIIE 533 IL+ T+G+GTEATRA IIE Sbjct: 398 DILKETEGIGTEATRASIIE 417 >UniRef50_Q312M7 DNA topoisomerase n=1 Tax=Desulfovibrio desulfuricans subsp. desulfuricans str. G20 RepID=Q312M7_DESDG Length = 805 Score = 223 bits (567), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 148/389 (38%), Positives = 210/389 (53%), Gaps = 26/389 (6%) Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 TPAD+ F+A+W P +E RL + AE V+ R G +V + +++ S+ P Sbjct: 287 TPADDVFSAVWH-----LPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPP 341 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 LPF L+ LQ EA RFG SA+ L I Q LYE KLITYPR+D RYL + F + + + Sbjct: 342 LPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLF--KEILKH 399 Query: 350 AISVHAPDLLPQPVVDPDIRNR------CWDDKKVDAHHAIIPT-ARSSAINLTENEAKV 402 +V+ L PQ V R + C +DKKV HHAIIPT A+ L+ E V Sbjct: 400 FRAVY--HLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNV 457 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 Y+++ R+++ F A F + + + FVA+ + + GW L R E++ Sbjct: 458 YDMVCRRFVAAFSAPASFMSSTVRVLSGEDVFVARGKVFKDIGW--LAVEPWRTAEDN-- 513 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 PLP + KG L + V RQT+ P HFTDA+LL+AM R V D++L+ ++ GL Sbjct: 514 PLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKER-GL 572 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAG---KALFHS-LPEMATRPDMTAHWESVL 578 GT ATRA IIE L RG++ KKG+ + +TD+G AL S LP+MA+ ++T WE L Sbjct: 573 GTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMAS-AELTGLWEKKL 631 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 I Y FMQ + L Q ++ K Sbjct: 632 KDIEAGNNTYPLFMQEIRTMLAQSVESIK 660 Score = 150 bits (380), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 87/229 (37%), Positives = 137/229 (59%), Gaps = 14/229 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-RW 61 L IAEKPS+AR IA ++ R+ DGF+E G +V+W +GHL+ A+P+ D + RW Sbjct: 5 LIIAEKPSVAREIAPLVGAVSRR-DGFLE-GPTHIVSWAVGHLVNIAEPEEQDEAWGGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 L LP++P +++L P +Q +++ +H + + +V+A D REG+L + + Sbjct: 63 ALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGEL----IFRRI 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 QL + VQR ND+ + + R++ L ++ L ++A ARA ADWL G+N++R Sbjct: 119 QLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 +T+ AG ++SVGRVQTPVL L+ R EIE+FV DF+ V+A Sbjct: 179 FTL---KAG--SLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARF 222 >UniRef50_C7H3L1 DNA topoisomerase n=1 Tax=Faecalibacterium prausnitzii A2-165 RepID=C7H3L1_9FIRM Length = 478 Score = 222 bits (565), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 154/489 (31%), Positives = 244/489 (49%), Gaps = 39/489 (7%) Query: 14 AIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKW 73 + A VL +R+ DG++E GNG +V+WCIGHL+E A P+ YD++Y +W++ADLPI+PE+W Sbjct: 2 SYAKVLGATNRQ-DGYLE-GNGYLVSWCIGHLVELAPPNVYDAKYVKWSIADLPILPERW 59 Query: 74 QLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQR 131 + S KQ ++++ +H + IV++ D REG+L+ L Y Q +K R Sbjct: 60 KYLVSASTKKQFGILQKLMHRPDVDSIVNSCDSGREGELIFR--LVYQQAGCKK--PFSR 115 Query: 132 CLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQG 191 ++ + A+ L+ ++E+ L +AL R RADW+ GIN +R ++ L Y Sbjct: 116 LWLSSMEESAIREGFAHLKPSTEYDALYNAALCRERADWMVGINASRLFSCL-----YGQ 170 Query: 192 VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQD 251 L+VGRV TPVL + V R+ I F + F+ V + + C Sbjct: 171 PLAVGRVMTPVLAMTVVREAAIAAFTPEKFYTVDLELTS--------------GCTA--- 213 Query: 252 EEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQ 310 R+ + +AE+++ + A + K +SE+ P + L+ LQ +A + G SAQ Sbjct: 214 SSRRIPEKSVAENLLEACRKEMVATIQRITHKEKSENPPPLYDLTTLQRDANRLLGYSAQ 273 Query: 311 NVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRN 370 LD Q LYE KL TYPR+D Y+ ++ + D+ P V +P R Sbjct: 274 QTLDYVQSLYE-KKLTTYPRTDSCYITDDD-EEMLEELTEELERFLDITPADVDEPAPRT 331 Query: 371 -RCWDDKKVDAHHAIIPT---ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIE 426 R + +KV HHAI+PT ++ L + E V LI + LM + + ++ Sbjct: 332 RRTVNREKVTDHHAILPTRSMLQADLEALPKGEQNVLKLIIARTLMAVSKPFRYLETLLT 391 Query: 427 LDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE--KGEVVERQ 484 + A +F AK + + E GW+ + D N L + E+ C E+ E Q Sbjct: 392 TECAGEEFTAKGKEVLEEGWKAVERKVLADILNRKQELAALPNATEIECGILNAELKEGQ 451 Query: 485 TQPPRHFTD 493 T PP+HFTD Sbjct: 452 TSPPKHFTD 460 >UniRef50_D1AV52 DNA topoisomerase n=2 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AV52_STRM9 Length = 667 Score = 221 bits (563), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 165/576 (28%), Positives = 278/576 (48%), Gaps = 64/576 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEK SL R IA + +K +G+IEC N VVT IGHLLE QP Y+ + Sbjct: 1 MKLIIAEKGSLGRNIAQAIG-IIKKNEGYIECKNDFVVTNAIGHLLELKQPKDYEENVGK 59 Query: 61 -WNLADLPIVPEK--WQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W LP +P ++++ V KQLNVIK + +A I++ GD DREGQ++VD +L Sbjct: 60 KWREYTLPFIPNNFVYEVKDDVGVKKQLNVIKGLMKKADLIINCGDADREGQIIVDNLLK 119 Query: 118 Y-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + + AP V+R + + + + + ++ L+ NS++ L ARA D+L G N+ Sbjct: 120 FNVNKAP-----VKRLWLPEQTEETIRKELNNLKDNSDYYNLQQEGYARAYMDYLLGHNL 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP--ADE 234 T +T L +L+ GRV P++ + RD+EI+NF+ + ++ V+ + + Sbjct: 175 TIMFTNLS-----GKMLNAGRVLVPIVKYIYDRDKEIKNFIVEKYYSVENENIVKLISSN 229 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 +F I EE ++ N+++ + A V + K + + FSL Sbjct: 230 KFKTI------------EEAKIYS--------NKLNSKKAKVIGIDSKEVKKQSKKLFSL 269 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S LQ E +K++ ++ N L I Q+LYE L TYPR++ YL E + ++ ++ Sbjct: 270 STLQSELSKKYKINFANSLKIIQELYEKGYL-TYPRTNTEYLSENEKGKVNDILGVLNNE 328 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 + + +DD K+++H AI T + L+ + KVY ++ ++L F Sbjct: 329 DLEFKDSK--------KVFDDSKIESHSAITITTKIPG-ELSVEQDKVYKMVYNRFLSNF 379 Query: 415 CP-DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 D + + + + + + +F K + + G+ + +D+ LP + DE Sbjct: 380 VKEDCIVSETTMIIKVDEEEFKLKGFVVKQLGFMKYEPKEYKDK------LPGLNLNDEF 433 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD------LKKILRATDGLGTEAT 527 E VE++T PP ++ L + F ++K+ K IL + +GTEAT Sbjct: 434 DIE-FRSVEKETTPPSKVNESELSKFLKN--PFKKEKNATEEEIYKDILEGIE-IGTEAT 489 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE 563 R GII+ K G+LT T+ G + L E Sbjct: 490 RTGIIDKCVKIGYLTLDNGVFDVTELGIFFINKLIE 525 >UniRef50_A1VBZ8 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=A1VBZ8_DESVV Length = 862 Score = 220 bits (561), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 137/393 (34%), Positives = 213/393 (54%), Gaps = 29/393 (7%) Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 D+RF +W P E R+ A+ + +G+ IV S + ++ PLPF Sbjct: 323 DDRFRGVWH-----RPPDRRETRVDSGEEADAIATACTGKLGIVESVQGRAGTQQPPLPF 377 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI- 351 L+ LQ EA RFG SA++ L Q LYET KLITYPR+D R+L +E F ++N + Sbjct: 378 DLTTLQREANTRFGYSAKDTLTHAQSLYETRKLITYPRTDSRHLTKELFG---EILNHLR 434 Query: 352 SVHAPDLLPQPVV-------DPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVY 403 +VH L P+ + R C DD+KV HHAIIPTAR + L+ E +Y Sbjct: 435 AVH--HLYPEETMLAVGRIKSGKARFACVDDRKVTDHHAIIPTARKGNLTQLSAPERNIY 492 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +++ R+ + FCP+A F + + + + F+AK + + GW ++ R E+ TP Sbjct: 493 DMVCRRTIAAFCPEAKFSTSTVTVMVGEHPFIAKGKVFKDKGW--MVVEPWRTAED--TP 548 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + KG +LL V+RQT+ P HFTDA+LL+AM R V+D L++ ++ GLG Sbjct: 549 LPQLRKGSKLLTLDVGPVKRQTKAPAHFTDASLLAAMETAGRLVEDDALRQAMKER-GLG 607 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS----LPEMATRPDMTAHWESVLT 579 T ATRA +IE L RG++ K+G+ + +TD G + + LP++A+ P++T WE L Sbjct: 608 TPATRAQVIETLVARGYVAKQGKKLVATDRGMQVAETVTTLLPDVAS-PELTGQWEKRLK 666 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 I Y FM+ + +++ + + + +R Sbjct: 667 DIEAGVDSYPAFMRSIRESVWHGVHRIRNRDIR 699 Score = 144 bits (362), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 88/227 (38%), Positives = 139/227 (61%), Gaps = 14/227 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-RW 61 L IAEKPS+AR IA ++ R+ G++E G +V+W +GHL+ A+P+ D +A RW Sbjct: 5 LIIAEKPSVAREIAPLVGAQGRRA-GYLE-GPDHLVSWAVGHLVGIAEPEEQDEAWAGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDYL 119 L LP++P ++QL+ P Q V++R L + + IV+A D REG+L+ + YL Sbjct: 63 TLEQLPMLPPRFQLRVLPETADQFAVLQRLLLDDRVTGIVNATDAGREGELIFRRI--YL 120 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 +K V+R +D+ + + +++ RL + E L ++A ARA ADWL G+N +R Sbjct: 121 VAGCDK--PVRRLWASDMTEEGLRKSLARLLPDEEKRNLGLAAFARAEADWLVGMNFSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 +T+ +G G++SVGRVQTPVL L+ R +IE+F +DF+ V+A Sbjct: 179 FTV---KSG--GLVSVGRVQTPVLCLLADRRRDIEHFTPQDFWTVEA 220 >UniRef50_B1ZV49 DNA topoisomerase n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZV49_OPITP Length = 855 Score = 217 bits (552), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 198/673 (29%), Positives = 298/673 (44%), Gaps = 108/673 (16%) Query: 3 LFIAEKPSLARAIADVL-------PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 L +AEKP + R +A L PHR G + G V GHL E A P+AYD Sbjct: 5 LIVAEKPDVGRTLAAALLGRTFSGMGPHR---GTLPTGEELTVVTARGHLFELAPPEAYD 61 Query: 56 SRYARWNLADLPIVPE-KWQLQ--PRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQL 110 +YA W + DLPI P +W Q PR + +++ + H EIV+A D REG++ Sbjct: 62 PKYAAWIVHDLPITPSTRWDFQQVPREDAANYIRILRDEIAAHLNDEIVNACDAGREGEV 121 Query: 111 LVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADW 170 + +V+ ++ + R + + + A + ++ + L + +R ADW Sbjct: 122 IFRKVMR--GCGAKRSARYTRMWAQVMTEEGLREAFAQRAPSANYNGLGEAGFSRDEADW 179 Query: 171 LYGINMT-RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV----- 224 L G+N+T A L R G V SVGRVQTP L LV RD I +F + F+E Sbjct: 180 LVGMNVTVLATKTLPRGRGNWKVWSVGRVQTPTLALVDTRDRLIADFKPQPFWEAFGGFG 239 Query: 225 ----KAHIVTPAD--ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTS 278 KA + A+ +R + P E + ++ + + P T Sbjct: 240 DVEAKADLDAYAESADRPKLLGSP----EVNTERSKKVFWSQEKANAFAAAAKAPPTYTV 295 Query: 279 YNDK-RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 + K +E PLPF L +Q +KR GL+ L + Q LYE KL++YPR+D RYLP Sbjct: 296 ADKKGTRTERPPLPFDLQEVQKLCSKRRGLTGTESLAVLQDLYEKRKLLSYPRTDSRYLP 355 Query: 338 EEHFAGRHA----VMNAISVHAP-------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIP 386 + A HA V+ A+ P +L+P V + R +DD KV H+ I+P Sbjct: 356 TKLKARLHADLARVLAAVKATHPQLHLASQELMPAEVA---AKARAFDDAKVSDHYGIVP 412 Query: 387 TARSSAINLTE------------------NEAKVYNLIARQYLMQ-----FCPDAVFRKC 423 T ++ I E +E Y + R+Y + + P AVFR Sbjct: 413 TGATAGIAELEGHELFVFLAVLQMTLMALDEPARYQTVTRRYTQEGGAGPYAP-AVFRTT 471 Query: 424 VIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVER 483 E+++ WR ++ E PLP A+ + + + E Sbjct: 472 REEIEVP-----------GFTRWR-------KETEKKSAPLP-AAQSSQATLDAVTLKEL 512 Query: 484 QTQPPRHFTDATLLSAMTGIARFV-------QDKDLKKILRATDGLGTEATRAGIIELLF 536 +T PP +TDATLL AM V Q L ++++ G+GT ATRAGII+ L Sbjct: 513 RTNPPDPYTDATLLDAMKYAGETVDPELDPEQADALIEVMK-DRGIGTPATRAGIIDKLV 571 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPD-----MTAHWESVLTQISEKQCRYQ-- 589 R FL ++G+ I +T+ G+ L L A PD +TA WE VL Q+ + + Sbjct: 572 ARQFLERQGKAIVTTENGRQLIREL--RARAPDFLSAQLTAEWELVLKQMERGEAKLNRG 629 Query: 590 DFMQPLVGTLYQL 602 F+ L+ + L Sbjct: 630 QFLDALLAQVVTL 642 >UniRef50_C7X7R3 DNA topoisomerase I (Fragment) n=7 Tax=Bacteroidales RepID=C7X7R3_9PORP Length = 653 Score = 213 bits (543), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 178/567 (31%), Positives = 271/567 (47%), Gaps = 46/567 (8%) Query: 43 GHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRF 91 GHLL QA P AY AR LP++P ++L R P +QL V++ Sbjct: 3 GHLLAQAPPSAYG--LARVERQALPLIPVPFRLVVRQVRTEQGYVTDPVAIRQLEVLRGL 60 Query: 92 LHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRS 151 L A +V A D REG+L+ +LDYL R+ R I+ L +A+ LR Sbjct: 61 LENADALVIATDAGREGELVSRYLLDYLGY----RKPALRLWISSLTEKAILNGFKNLRE 116 Query: 152 NSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDE 211 + +F L ++A AR ADW+ G+N A LG AG G S+GRVQTP L LV RR Sbjct: 117 DGDFDNLALAARARREADWILGVN---ASITLGIAAG-MGNHSLGRVQTPTLALVCRRYL 172 Query: 212 EIENFVAKDFFEVKAHIVTPADE-RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS 270 E +FV F ++ + + FT + Y+ +E AE R+ Sbjct: 173 ENRDFVPVSCFHLQTGVCKYGQKVLFTCPLR-------YERKED-------AEKARARLE 218 Query: 271 GQPAIVTSYNDKRE-SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 G+ +K+E E PLP L+ LQ EA R G++A L + Q+LYE ++YP Sbjct: 219 GKGRCTVLAVEKKEVMEQPPLPHDLTGLQREANTRLGMTAGQTLAVVQRLYE-RGCVSYP 277 Query: 330 RSDCRYLPEEHFAGRHAVMNAISVHAPDL--LPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 R+ CR++PE+ F ++ + H P + +++ + D+ V HHA++ T Sbjct: 278 RTGCRHIPEDIFKQAPTLVATLKGH-PHFGRHAERLLEKGLNPHAVDESSVAGHHALLIT 336 Query: 388 ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWR 447 L+ +E +Y+LIA + L F V ++ D +F A+ + GWR Sbjct: 337 GEMPE-GLSPDEQNIYSLIAGRMLEAFSEGCVREVIRVKADYGGMEFEAETSCVKYPGWR 395 Query: 448 TLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 + + EE+ TPLP +G+ L + E++E T+P FT+A LL+AM A Sbjct: 396 DIYNGPDMAEES--TPLPQFHQGETLAVLETEILEDSTKPLPPFTEAGLLAAMEN-AGGT 452 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MAT 566 D + KK + GLGT TRAGII+LL R ++ + G + T+ G ++ + + + Sbjct: 453 ADGESKKKITERCGLGTPGTRAGIIDLLVARRYVERIGNRLIPTEKGLEIYGIVGDKLIA 512 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQ 593 MT WE L +I E + FM+ Sbjct: 513 DAAMTTAWEEALREIEEGRLSAGKFMK 539 >UniRef50_B7IYV7 DNA topoisomerase n=7 Tax=Bacillus cereus group RepID=B7IYV7_BACC2 Length = 687 Score = 210 bits (535), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 138/473 (29%), Positives = 240/473 (50%), Gaps = 24/473 (5%) Query: 137 LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGY------Q 190 L A+++A L+ E PL SA +R+ AD+ G++ TRA +I +N+ Q Sbjct: 6 LAAAAIKKAFLSLKDGEETKPLFYSAYSRSVADYYVGLSATRALSIQMKNSKSTENMKNQ 65 Query: 191 GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQ 250 G SVGR+QTP++ ++ R+EEI +F ++ F+ ++A + +T W+ + Sbjct: 66 GTWSVGRIQTPLIRIICDREEEILDFKSEPFWTIQAQFNIGGN-TYTGKWKD------LK 118 Query: 251 DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQ 310 + + + A +V+++ + A + P ++LS LQI A K + +S++ Sbjct: 119 NNIDQFNTKDAAVLIVSKVKDKEATAEKVTEDILKIKPPQFYNLSDLQIRANKLYKMSSK 178 Query: 311 NVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS-VHAPDLLPQPVVDPDI- 368 VLD Q LYE I+Y R+D Y+ + ++ +S + Q + +P Sbjct: 179 AVLDAGQALYEAS-YISYVRTDSNYVTDAEINEFPEIIKGLSQIGMYREFTQKIKEPGKL 237 Query: 369 --RNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVI 425 ++R ++KKV HHAI+PT + L EN+ K+Y+LI R + DA + I Sbjct: 238 KHQSRYQNNKKVSDHHAILPTGVIPDFSKLNENQKKIYDLIVRSVIAAHYEDAEVSQTTI 297 Query: 426 ELDIAKGKFVAKARFLAEAGWRTLL---GSKERDEENDGTPLPVVAKGDELLCEKGEVVE 482 ++ + KF+ + GWR ++ S ++++N +P++ +G + +K + E Sbjct: 298 ITNVNQEKFITSGKVSKIEGWRDVIHEEKSTTKEQDNSNESIPILNEGSRGITDKVSIKE 357 Query: 483 RQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLT 542 +T+P + +T L+S M R V+DK L K L +T+GLGTEATR+ IIE +F +G++ Sbjct: 358 GKTKPKKRYTQGDLISVMKNCGRNVEDKALAKSLNSTEGLGTEATRSSIIENIFAKGYII 417 Query: 543 KKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 K + T K L +L + P MTA WE L I+E Y+ F++ Sbjct: 418 CKNNVVFPTPKAKMLIEALGRESIIASPIMTARWEQALKAIAEGDYDYKHFIK 470 >UniRef50_A5N5N2 DNA topoisomerase n=4 Tax=Clostridium RepID=A5N5N2_CLOK5 Length = 784 Score = 207 bits (527), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 168/559 (30%), Positives = 265/559 (47%), Gaps = 67/559 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-YA 59 M+L +AEKPSLA I + +R DG+ E ++T+ GHLL D Y R Sbjct: 1 MKLILAEKPSLALNIVKSIGNMNR-NDGYFE-NRDYLITFAYGHLLRLYDVDNYFKRGKT 58 Query: 60 RWNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEV 115 +WNL +LP VPE ++ + R V KQ VIK + ++ +EIV+ GD DREG+++V+ + Sbjct: 59 KWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNI 118 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + + + V+R + + Q + + + L+ N ++ L LAR DW YGIN Sbjct: 119 ISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGIN 178 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI------- 228 +TR +I Q L VGRV P++ + RD IENF + +FE+ A I Sbjct: 179 LTRYLSIKS-----QTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEI 233 Query: 229 -VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 D RF+A DE R A +++N + + AIV K+ + Sbjct: 234 KAKLKDRRFSA------------DE------REKAANLLNSLKDKKAIVDKVEKKKVKKQ 275 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 P FSL LQ + K+F +S + L QKLYE TYPR++ YL E ++ Sbjct: 276 PPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECG-FTTYPRTNTEYLAENEKGKIKSI 334 Query: 348 MNAISVHAPDLLPQPVVDPDIRN--RCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYN 404 + + + VD D ++ + +D+ KV++H AI PT + I L+E+E KVY Sbjct: 335 IEVMK-------EKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYT 387 Query: 405 LIARQYLMQFC-PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 I +++ F + + + + + I K + + G+ K+ +E Sbjct: 388 AIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENE------ 441 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG---------IARFVQDKDLKK 514 LP + DE L K V E+QTQ P T++ L + + + D++ K Sbjct: 442 LPDFVE-DEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKM 500 Query: 515 ILRATDGLGTEATRAGIIE 533 IL + +GT ATRA II+ Sbjct: 501 ILEGCE-IGTVATRAVIIK 518 >UniRef50_D1NFZ9 DNA topoisomerase III (Fragment) n=20 Tax=Haemophilus influenzae HK1212 RepID=D1NFZ9_HAEIN Length = 311 Score = 204 bits (520), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 102/153 (66%), Positives = 118/153 (77%), Gaps = 9/153 (5%) Query: 156 VPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEN 215 +PL SALARARADWLYGINMTRAYTI GR GY GVLSVGRVQTPVLGL+VRRD EIE+ Sbjct: 1 IPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEH 60 Query: 216 FVAKDFFEVKAHIVTPADER---------FTAIWQPSEACEPYQDEEGRLLHRPLAEHVV 266 F KDFFEV+A + E F+A+WQPS+ACE YQD++GR+L + LAE+VV Sbjct: 61 FQPKDFFEVQAWVNPDNKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLAENVV 120 Query: 267 NRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 RI+ QPA VT Y D RE E+APLP+SLSALQI Sbjct: 121 KRITNQPAEVTEYKDVREKETAPLPYSLSALQI 153 >UniRef50_B5K387 DNA topoisomerase III, putative n=5 Tax=Octadecabacter antarcticus RepID=B5K387_9RHOB Length = 718 Score = 204 bits (520), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 172/606 (28%), Positives = 287/606 (47%), Gaps = 63/606 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN--GQVVTWCIGHLLEQAQPDAYDSRYAR 60 + IAEKPS AR + + L GN G++++ GH+ + A+P + + + Sbjct: 5 IVIAEKPSQARNLREAL-------------GNRYGRILS-ARGHIFKLAEPAEVNEAWKK 50 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQ--LNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+ L + L+P S K + IK L EA ++ A D DREGQ + + +L Y Sbjct: 51 WSYEVLRPESGFYPLRPDNSHGKDKLIAEIKAALKEADRVIIATDCDREGQAIGENILRY 110 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + +V R + + +P ++ ++ + L+ N + PL +A+ARA++D + + TR Sbjct: 111 FKF----KGEVLRAMFSAEDPVSLRQSFEALKPNEHYRPLYAAAVARAQSDQIANLTATR 166 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A TI + G +G + +GRV+TP +G+V R+ EI+ F + +F++ V+ E Sbjct: 167 AVTIALKPHGMKGAIGIGRVKTPTMGIVCAREREIQGFEPRPYFDLWVD-VSDGKEGLRL 225 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P+ E R+ + LA+ ++ + +K++ + P L LQ Sbjct: 226 KHFPA--------HEARVFDQDLAQRIIASFDPWKGPLQVTFEKKK-QPPPRLMDLPLLQ 276 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 AA R+G SAQ LD+ Q+LYETHK+ TYPR++ +YLPE A+++ + Sbjct: 277 QRAA-RWGWSAQKTLDVAQRLYETHKVTTYPRAETKYLPEAEKQNAQAMLDGLRE----- 330 Query: 359 LPQPVV---DPDIR---NRCWDDKKV--DAHHAIIPTARSSAI------NLTENEAKVYN 404 LP V +P R C+ D+ + +HHAIIP ++ L+ +E +++ Sbjct: 331 LPFVKVAYENPTYRMGKRGCFSDEGLAGASHHAIIPNFKTRDKWARVLGALSGDERRLFE 390 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG-----SKERDEEN 459 LIA Y PD + + I L + KF A + GWR LG SK+ D E Sbjct: 391 LIALSYTAAIGPDRHYDRTEISLMAGQRKFAASGIVERQPGWREALGADPDASKKSDAEA 450 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 LP + K ++ T+PP F + TL+ AM ++ +D + L+ Sbjct: 451 AAI-LPPWKDRQIVNAVKAGADKKTTKPPARFNEGTLIKAMQEAWKYARDPKTAERLKGA 509 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWE 575 G+GT ATRA I+E L + +++ + A++ L PE+ P TA E Sbjct: 510 AGIGTPATRASILEGLKTQNLFEVIDKHLAPSTLALAIYDVLLKEAPEILD-PAATAEME 568 Query: 576 SVLTQI 581 L I Sbjct: 569 LALDGI 574 >UniRef50_P40114 DNA topoisomerase 1 n=47 Tax=Bacillus cereus group RepID=TOP1_BACAN Length = 870 Score = 203 bits (517), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 162/587 (27%), Positives = 290/587 (49%), Gaps = 42/587 (7%) Query: 37 VVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTK----QLNVIKRFL 92 +V+WC GHLLE P+ D +Y + L LP++ QP V + QL ++ + L Sbjct: 28 IVSWCRGHLLELKNPEEMDPKYKLFQLEHLPLI-----FQPSYKVIQENAEQLQILVKLL 82 Query: 93 H--EASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR 150 + V+ D DREG+L+ EV +Y + K+Q R + +E A++RL Sbjct: 83 QRPDVDHAVNICDADREGELIYREVYEYAGV--NKKQS--RVYKSSFEAAELEAALNRLE 138 Query: 151 SNSEFVPLCVSALARARADWLYGINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRR 209 S S++ L SA AR D+L G+N+TR T L +N + +LS GRVQ +L + +R Sbjct: 139 SASKYDGLAYSAKARQYLDYLLGMNITRGCTTKLAQN---KFLLSSGRVQMCLLHEIRQR 195 Query: 210 DEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI 269 + IEN+ + ++ ++ ++T +P E ++L+ + + + Sbjct: 196 ELAIENYREQSYYHLQ--LITDL------------GLKPVMKTEDQVLNPSPLKSLGENL 241 Query: 270 SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 Q V + + ++ L ++L+ L +A + ++A+ Q LYE ITYP Sbjct: 242 KDQYLTVEDFKEGTRKQNPKLLYNLTDLYKDAHAQLQINAETAKKHIQNLYE-EGFITYP 300 Query: 330 RSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPV-VDP-DIRNRCWDDKKVDAHHAIIPT 387 RS R+LP E VM A++ LL Q V +D DI+++ +DD V +H AIIPT Sbjct: 301 RSSSRHLPTEQVDRVKGVMQALAKSRYSLLVQSVDIDAIDIKHKTFDDDLVSSHFAIIPT 360 Query: 388 ARS-SAINLTENEAKVYNLIARQYLMQFCPDAVFR-KCVIELDIAKGKFVAKARFLAEAG 445 + E E ++Y+L+ ++++ F AV+ + V +D + K L E G Sbjct: 361 TKQYQEEGRPEIEKQLYSLVVKRFVGNFMRPAVYLVRDVSLIDAMGNTYQIKESVLREKG 420 Query: 446 WRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 + + + ++E + +P++ KG EL E+ E +T+ P T++++L+ M R Sbjct: 421 FLEVFQEEVKEESVETFKVPILQKGQELQIYDFELQESKTKKPALHTESSILTFMETAGR 480 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM 564 + D+ LK++++ +GT AT A I +L ++ F+ +KG+ I +T G+A P Sbjct: 481 KIDDEHLKELMKGKR-IGTVATEAAFIPVLHEKNFIDIEKGKII-TTPIGRAFIEQFPVQ 538 Query: 565 ATR-PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 + P TA E ++ +I + + Y++F+ + ++ + R P Sbjct: 539 QIKDPLYTAEMEGMIHRIEKNEMSYENFIAQTNAFVQKITQEIIRIP 585 >UniRef50_C2XKX2 DNA topoisomerase n=7 Tax=Bacillus cereus group RepID=C2XKX2_BACCE Length = 894 Score = 201 bits (512), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 176/632 (27%), Positives = 302/632 (47%), Gaps = 58/632 (9%) Query: 3 LFIAEKPSLARAIAD----------VLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPD 52 LFIAEKP +A I + KP+ G+ E + +V+WC GHLLE P+ Sbjct: 12 LFIAEKPKVANEIMKSPRFRHSQKYIGSKPYY---GYYE-NDHYIVSWCRGHLLELKNPE 67 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTK----QLNVIKRFLH--EASEIVHAGDPDR 106 D +Y + L LP++ QP V + QL ++ + L + V+ D DR Sbjct: 68 EMDPKYKVFQLEHLPLI-----FQPSYKVIQENAEQLQILVKLLQRPDVDHAVNICDADR 122 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+L+ EV +Y + K+Q R + +E A++RL S S++ L SA AR Sbjct: 123 EGELIYREVYEYAGV--NKKQS--RVYKSSFEAAELEAALNRLESASKYDGLAYSAKARQ 178 Query: 167 RADWLYGINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK 225 D+L G+N+TR T L +N + +LS GRVQ +L + +R+ IEN+ + ++ ++ Sbjct: 179 YLDYLLGMNITRGCTTKLAQN---KFLLSSGRVQMCLLHEIRQRELAIENYREQSYYHLQ 235 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 ++T +P E ++L+ + + + Q V + + Sbjct: 236 --LITDL------------GLKPVMKTEDQVLNPSPLKSLGENLKDQYLTVEEFKEGTRK 281 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 + L ++L+ L +A + ++A+ Q LYE ITYPRS R+LP E Sbjct: 282 HNPNLLYNLTDLYKDAHAQLQINAETAKKHIQNLYE-EGFITYPRSSSRHLPTEQVDRVK 340 Query: 346 AVMNAISVHAPDLLPQPVVDPD---IRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAK 401 VM A+ LL Q V D D I ++ +DD V +H AIIPT + E E + Sbjct: 341 GVMQALVKSRYSLLVQSV-DIDAIGIEHKTFDDDLVSSHFAIIPTTKQYQEEGRPEIEQQ 399 Query: 402 VYNLIARQYLMQFCPDAVFR-KCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 +Y+L+ ++++ F AV+ + V +D + K L E G+ + + +E D Sbjct: 400 LYSLVVKRFVGNFMRPAVYLVRDVSLIDAMGNTYQIKESVLREKGFLEVFQEEVEEESVD 459 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 +P++ KG EL E++E +T+ P T++++L+ M R + D+ LK++++ Sbjct: 460 AFKVPILQKGQELQICDFELLESKTKKPALHTESSILTFMETAGRKIDDEHLKELMKGKR 519 Query: 521 GLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEMATR-PDMTAHWESVL 578 +GT AT A I L ++ F+ KG+ I +T G+A P + P TA E ++ Sbjct: 520 -IGTVATEAAFIPALHEKNFIDIDKGKII-TTPIGRAFIEQFPVQQIKDPLYTAEMEGMI 577 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 +I + + Y++F+ + ++ + R P Sbjct: 578 HRIEKNEMSYENFIAQTNAFVQKITQEIIRIP 609 >UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium RepID=Q33E26_ENTFC Length = 787 Score = 193 bits (491), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 153/583 (26%), Positives = 276/583 (47%), Gaps = 44/583 (7%) Query: 37 VVTWCIGHLLEQAQPDAYD--SRYARWNLADLPIVPEKWQLQPRPSVTK--QLNVIKRFL 92 +VTW IGHL+ + P+ Y+ +W+L +LP +P+ +L+ S K Q +++K L Sbjct: 43 IVTWGIGHLVGLSLPEKYEWLPNKDKWHLDNLPFLPKFNELKYEVSKGKNQQFSIVKSCL 102 Query: 93 HEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSN 152 A EI+ A DPDREG+ + + + + + ++R IN L + + + LR++ Sbjct: 103 ENADEIIIATDPDREGENIAYNIFKLCKQSIFNKP-IKRLWINSLVQKEIIKGFKNLRNS 161 Query: 153 SEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEE 212 E + A AR AD+L G+N T Y++ + G GV+S+GRVQTPV LVV D Sbjct: 162 EETISYFKEANARQIADYLVGMNYTELYSLKLQEKGISGVVSLGRVQTPVNTLVVENDLA 221 Query: 213 IENFVAKDFFEVKAHIVTPADERFTAIWQPS---EACEPYQDEEGRLLHRPLAEHVVNRI 269 I+NF + + ++ H D++ AI++ S E ++++ + + ++ +I Sbjct: 222 IKNFRPEKYKTIECH---TTDKQPKAIFKNSLEYFKLEKFEEDTKKFGLDSASTGIIKKI 278 Query: 270 SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 K+++E L FSL +Q A K++ SA+ I Q LY+ L +YP Sbjct: 279 EVS---------KKQTEPQKL-FSLGGIQEYANKKWKYSAKKTDKIIQSLYDRGYL-SYP 327 Query: 330 RSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR 389 R+D + F A ++ + P ++P + R D+ KV H+A+IPT Sbjct: 328 RTDSELITTNEFEYLKANLDVYKSVLGISIDTPCLEP--KKRFVDNDKVLEHYALIPTMD 385 Query: 390 SSAI-NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRT 448 I NLT +E +Y ++ R+ + F + + LD+ +F GW+ Sbjct: 386 IPDIANLTLDEKNIYEIVTRRACLMFAEPYKYENTKVTLDVNGLEFTTSGNVPISLGWKQ 445 Query: 449 LLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 + + + ++ + T LP + E + +++ T+ P+ T+ LL TGI Sbjct: 446 VDTNLDESDDKEET-LPKFHE-QETINIDIRFIDKLTKEPKRLTEGKLL-GKTGIM---- 498 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MA 565 A GLGT ATR+ I++ L R ++ + ++ T G L+ + Sbjct: 499 ---------AKLGLGTPATRSNIVDTLLNREYIKIENTNVYPTPKGYLLWDLTKNKDLLI 549 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 +P+ TA WE L +I++ + F++ + + + + K+ Sbjct: 550 GKPENTAIWEESLGKIAQGNYTQEAFLRNIYNYINKTVSDLKK 592 >UniRef50_B1BR51 DNA topoisomerase n=7 Tax=Clostridium perfringens RepID=B1BR51_CLOPE Length = 716 Score = 188 bits (478), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 166/647 (25%), Positives = 302/647 (46%), Gaps = 74/647 (11%) Query: 1 MRLFIAEKPSLARAIADVLP---KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY-DS 56 MR+ IAEKPS A+ I + L + + DG+ E N VTW GHL + Y +S Sbjct: 1 MRVIIAEKPSYAKTIVNALEHIGEHFTRRDGYFESIN-YYVTWQFGHLFRLYTIEEYINS 59 Query: 57 RYARWNLADLPIVPE--KWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLV 112 RW LP +P+ K++L+ KQ VI++ +++ +EIV +GD D EG LLV Sbjct: 60 EDKRWKENILPYIPKQFKFRLKDDNGAKKQYQVIRKLINDKKVTEIVESGDADSEGNLLV 119 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 V+ + ++ R +D + + +++ L+ + + A R D+L Sbjct: 120 TLVVSDVFRRDNLNKKRTRLWSSDQSETTIIESLNNLKDVNFYRNYSNEAYTRTCMDFLL 179 Query: 173 GINMTRAYTIL-GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFF------EVK 225 GIN+TR ++++ R G + + S+GR T ++ ++ RD EI+NF+ ++ E K Sbjct: 180 GINLTRKFSLMNNRLTGARDIFSIGRCNTSIVDIIYERDMEIKNFIPVQYWQLESEEETK 239 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 IV D+ + + +A E LAEH ++ AIV + +K + Sbjct: 240 GEIVKLIDKDKFELVKEVKAKE-------------LAEH----LNSCKAIVENVEEKLIT 282 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 ++AP FSL ++Q + R+ +S + L Q LYE +TYPR++ YL E+ Sbjct: 283 KTAPKLFSLPSVQGILSDRYKISLGDSLKAIQSLYEAG-YVTYPRTNSEYLSEDEVGKVR 341 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR---SSAINLTENEAKV 402 ++N ++ +L + +++ V++H A+I T++ ++N T E V Sbjct: 342 GIINKLNREGYNLKLKE------SKAIFNNAMVESHSALIITSKLPPKGSLNKT--EEIV 393 Query: 403 YNLIARQYLMQFCPDAV-FRKCVIELDIAKGKFVAKARFLAEAGWRT---LLGSKERDEE 458 YN I +++ +F + + +I + + ++ K + E G+ L SKE Sbjct: 394 YNTIKNRFISKFLDEETKISQTIITITVGNRQYQLKGEVIKEKGFYNFEPLPKSKE---- 449 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR--FVQDKD-LKKI 515 LP + KGD ++ + ++++T+PP TL+ + R + D++ K + Sbjct: 450 --TITLPNLKKGD-IVNIDFKPIKKETKPPSKLNLKTLIKMLENPFRKEYKTDEEAFKDV 506 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--TRPDMTAH 573 L + +GT ATR GIIE K G++ + + TD G L +L + + T Sbjct: 507 LEGIE-IGTPATRTGIIENTKKYGYIIESKGTLSITDKGIYLIETLRRLNIDISKNRTVE 565 Query: 574 WESVLTQISEKQCRYQDFMQPLVGT------LYQLIDQAKRTPVRQF 614 + +L ++ +++ + PL L ++ D + T + F Sbjct: 566 FSKILKKV------FRNELAPLAAVDIIKSELNEMFDSIQETKIEGF 606 >UniRef50_B0MQN7 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MQN7_9FIRM Length = 667 Score = 188 bits (478), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 150/525 (28%), Positives = 243/525 (46%), Gaps = 48/525 (9%) Query: 130 QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGY 189 +R I DL P + +A LR + PL + R+ DWL GIN + A T+ + G Sbjct: 4 KRVWITDLTPFKIRKAFAELRPAKDMKPLENAGRIRSATDWLVGINTSVAATL--KFGGT 61 Query: 190 QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPY 249 V + GRV+ P L ++V+R+ EI N+V K F+++ A+I +FTA EA + Y Sbjct: 62 DNVFACGRVKMPTLAMIVKREREIRNYVKKPFYKIVANIEANDGAKFTA-----EAADKY 116 Query: 250 QDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSA 309 E A+ ++ I A ++ +APL ++ + L + +K L+ Sbjct: 117 DTETA-------AKTAIDEIKSNTAKAIKVEVSQKQTAAPLLYNTTHLLADLSKCTDLTI 169 Query: 310 QNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV------HAPDLLPQPV 363 + + Q LYE ++LITYPR+ +L + A + + I + A +P Sbjct: 170 DMLTKLVQSLYE-NRLITYPRTSSEHLTD---AMKDETVKIIKLLFEMPEFAKYAIPVDK 225 Query: 364 VDPDIRNRCWDDKKVDAHHAIIPTAR--SSAINLTENEAKVYNLIARQYLMQFCPDAVFR 421 P R R +DD KVD+H AI PTA + ++ENE K Y L+A + P AV Sbjct: 226 FAPCTR-RHYDDSKVDSHTAITPTALVPNDLSGMSENERKAYTLLALSIIRTVYPKAVTE 284 Query: 422 KCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVV 481 I F A + GW + D T LP + K ++ +V Sbjct: 285 NIKAVFQIDNQLFTAIGTNIINPGWFAV------DATPKVTGLPEIVKDNDYKVIGFDVK 338 Query: 482 ERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD-GLGTEATRAGIIELLFKRGF 540 E Q +PP+++TDATLL+AM + D+ + ++ T GLGT ATR GII+ L+ +G+ Sbjct: 339 EGQNEPPKYYTDATLLTAMELAGNNITDEQTRSYIKLTKRGLGTAATRQGIIKELYDKGY 398 Query: 541 LTKKGR-------YIHSTDAGKALFHSL----PEMATRPDMTAHWESVLTQISEKQCRYQ 589 + ++ R I T+ G + ++L P+M + DMT E L +I+ + Sbjct: 399 IARRTRKNGNAVKSIMPTEKGMYIINTLEKIVPDMLS-VDMTGDMEMELDKIARGESDGN 457 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRG--IVAPGSGGSADKKKAA 632 +F+ + + ++Q K + G ++ P G KKK Sbjct: 458 NFLNEYKKLVIKWVEQIKNSDTSAMTGNTLICPLCGKPVIKKKVG 502 >UniRef50_C7N9L8 DNA topoisomerase n=4 Tax=Fusobacteriaceae RepID=C7N9L8_LEPBD Length = 690 Score = 184 bits (467), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 166/619 (26%), Positives = 291/619 (47%), Gaps = 54/619 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L IAEKPSLAR IA L K +G++E +V+W GHL + D Y +W Sbjct: 3 KLIIAEKPSLARNIASALDIRVNK-EGYME-NEKYIVSWAFGHLFKLRDVDGYVGEKRKW 60 Query: 62 NLADLPIVPEKWQLQPRPS--VTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLD 117 + LP P++++ + + + KQ ++K ++ E EIV+AGD DREGQ++VD + Sbjct: 61 SEVKLPFFPKEFEFELKNDLGIKKQYKILKNLINSKEVDEIVNAGDADREGQIIVDII-- 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 A + ++++R + + + + +AI+ L N ++ L LAR DWL GIN+T Sbjct: 119 --INAIKTDKKIKRLWLPEQTEETIRKAINNLEDNFKYRNLHNEGLARTYMDWLMGINLT 176 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R Y L N + VGRV PV+ + RD I+NF + +F +++ T + Sbjct: 177 R-YISLKANM----LFPVGRVLIPVIKYIYDRDLTIKNFSPEKYFTIESE--TMCNGTLL 229 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + C D++ LL A++ ++ IV +K + P FSLS L Sbjct: 230 KL-----IC----DKKYNLLELEKAKNYSYELNRNKGIVKDITEKEIILNPPKLFSLSKL 280 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q + +K +S L+ QKLYE ITYPR++ YL EE + V I +++ Sbjct: 281 QSKLSKEKKISFAKSLETIQKLYEKG-FITYPRTNTEYLAEEE---KDKVRELIKLYSDY 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 L + + +D K+++H A++PT + +N L E ++ I +++ F Sbjct: 337 RL-----EFKDSKKIFDSSKIESHSAVMPTLKIPDMNSLNLEEKIIFETIRNRFISNFLK 391 Query: 417 D-AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 + A+ + I++ + F K + + + G+ K ++ LP E+ Sbjct: 392 EQAIINQTEIKIAVGNEIFNLKGKSVKQEGFLKYENQKVDNK------LPYFEISQEIDI 445 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIAR---FVQDKD----LKKILRATDGLGTEATR 528 + +VV++ T P+ T+ L + + R +D+D ++I++ + +GTEATR Sbjct: 446 D-FKVVDKLTVSPKKVTEENLSNYLKNPFRKEKKQEDEDDTQEYREIMKGVE-IGTEATR 503 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFH--SLPEMATRPDMTAHWESVLTQISEKQC 586 GIIE K G++T + + T+ G L L + + T + + I + Sbjct: 504 TGIIENAKKYGYITSEKQNFSITEKGIKLIELLDLLHINLYAEKTVEFSMLQKDIYNNRK 563 Query: 587 RYQDFMQPLVGTLYQLIDQ 605 D ++ L +I+Q Sbjct: 564 NISDIIEKTENELQNIINQ 582 >UniRef50_D0RWS4 DNA topoisomerase n=1 Tax=Streptococcus sp. 2_1_36FAA RepID=D0RWS4_9STRE Length = 626 Score = 183 bits (465), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 156/591 (26%), Positives = 278/591 (47%), Gaps = 87/591 (14%) Query: 43 GHLLEQAQPDAYDSRYARWNLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVH 100 GHL E P W+LA LP+V ++ L+ P+ + I + A E++ Sbjct: 90 GHLFEYGLPKD------NWDLAKLPLVDVSFKQYLKKDPTSKEMFKRIYEEVTAADEVII 143 Query: 101 AGDPDREGQLLVDEVLDYLQLAPEKRQQVQ-RCLINDLNPQAVERAIDRLRSNSEFVPLC 159 D DREG+ + +L ++ PE + +++ R +N + +A++RA +R E Sbjct: 144 GTDADREGERIAYSILSHI---PEGKAKIKKRLWVNSMTTRALQRAFQNMRDPQETYSFY 200 Query: 160 VSALARARADWLYGINMTRAYTILGRNAGYQGV--------LSVGRVQTPVLGLVVRRDE 211 + A ARA++DWL G+N++ T+ N QG+ LSVGRVQTPV+ L+ D Sbjct: 201 LEAEARAQSDWLVGMNLSPMATL---NLQKQGMLPKAKGNSLSVGRVQTPVVRLICENDL 257 Query: 212 EIENFVAKDFFEVK-----AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVV 266 I NFV + +++++ ++ ++FT +E L R LA+ Sbjct: 258 AIRNFVQQTYWKLQLEDKENEVIFTNKDKFT------------DSDEVLELSRSLAD--- 302 Query: 267 NRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLI 326 A+V+S + +++ AP F+LS LQ AA+R+ A + + LY K + Sbjct: 303 ------VALVSSVEAEEKAKPAPALFNLSDLQSYAARRWKFEATKTERLVEGLY-LKKYL 355 Query: 327 TYPRSDCRYLPEEHFAGRHAVMNA----ISVHAPDLLPQPVVDPDIRNRCWDDKKV--DA 380 +YPRSDCR++ E+ F +++ + H + +P R+ D KV + Sbjct: 356 SYPRSDCRFITEDEFNYLRQYLSSYQDTVHCHFESVFLEP------RDFYVDPAKVAKSS 409 Query: 381 HHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKAR 439 H+A++PT + + L+ +E +Y + ++ ++ F D ++ ++L+ F K + Sbjct: 410 HYALVPTENIPNLLRLSPDERLIYEAVVKRAILMFAADCRYQTTTVQLENKGQVFQMKGK 469 Query: 440 FLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSA 499 + GW + + + D LP D + C+ +V+ T+PP+ T++ L+ Sbjct: 470 ITIDPGW---IEWSDLPVKKD-VELPNYRLDDPVACQIT-IVDGVTKPPKRLTESHLIGQ 524 Query: 500 MTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLT--KKGRYIHSTDAGKAL 557 + ++ GLGT+ATR +I+ + RG++ KK + TD G L Sbjct: 525 V--FPKY--------------GLGTQATRGAVIQTIQSRGYVKKDKKTDQLFPTDKGYLL 568 Query: 558 FHSLPEMA-TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + L + + P+ T WE L+QI E +DF+ + L I+QAK Sbjct: 569 INYLWDNEFSNPETTGGWELFLSQIGEGAINPRDFVNAIKDKLTIQIEQAK 619 >UniRef50_B0S4M6 DNA topoisomerase n=1 Tax=Finegoldia magna ATCC 29328 RepID=B0S4M6_FINM2 Length = 672 Score = 182 bits (463), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 173/625 (27%), Positives = 295/625 (47%), Gaps = 78/625 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY-----D 55 M+L IAEK +A+ IAD + K DG+ + + V TW GHL +P+ Y D Sbjct: 1 MKLIIAEKKDMAQKIADSIGK-FTPEDGYYDVLDCHV-TWTWGHLFGLKEPNEYENQGWD 58 Query: 56 SRYARWNLADLPIVPEKWQLQ---PRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 ++A ++ DLP++P K+Q + + K ++IK ++ EI+++ D +REG+L+ Sbjct: 59 KKWADSSIDDLPMIPNKYQYKLTGNKDQFKKIEDLIKS--NKYDEIINSCDAEREGELIF 116 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 + ++L + E + +V R N N + +A++ + E+ + A +R++ADWL Sbjct: 117 RLLYNHLDI-DENKTKVTRMWCNTTNKDGLLKALEERKDIKEYDGYYLEADSRSKADWLI 175 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N++R Y + +GRV TP L L++ RD EIENF D + + Sbjct: 176 GMNLSRLYMF-----KFFRKFVIGRVMTPTLCLIIERDLEIENFEESDIYNLVGEYNGF- 229 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 +F + E C+ ++D L + V I + + AP F Sbjct: 230 --QFKRKFDTPEECDRFKD---------LKDFTVVDIVEEKK----------KKKAPKLF 268 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP---EEHFAGRHAVMN 349 LS LQ +A +G + + L+I + LY + +YPRS+ YLP EE F+ + N Sbjct: 269 KLSTLQQQANVEYGYTLKQTLNILESLY-LKGITSYPRSNMEYLPADLEESFS--ETLKN 325 Query: 350 AISVHAPDLLPQPVVDPDIR--NRCWDDKKV--DAHHAII--PTARSSAINLTENEAKVY 403 L + DI +C +D+K DAH+AII T NL+++E +Y Sbjct: 326 L-------YLAWFIEKDDIEGAKKCINDEKAQKDAHYAIIIVNTKTKEIDNLSKDERNIY 378 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIA-KGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 +LI+R+ + D + IE DI +F K R + G+ + +K + ND Sbjct: 379 DLISRRMIEATMKDFEY----IEQDIQLNDEFSGKKRKSTQEGFNKIQYNKL--QYNDNL 432 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 L KG C+ E+ + +T+P FTDAT++S+M + KD+ + + G+ Sbjct: 433 DLN---KGQNFQCDL-EIKKTKTKPKPRFTDATIVSSMENL------KDIDEKYKG--GI 480 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQIS 582 GT ATR IIE L + ++ + + + ST + L+ L + +TA E L ++ Sbjct: 481 GTPATRDSIIEKLVEYKYIERSKKTLTSTPIARLLYKLLSKQIKTVGLTAALEEKLEEVR 540 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAK 607 + F+ + + ID+ K Sbjct: 541 LGNIEQETFLNFIEKYILNEIDRVK 565 >UniRef50_A6L0J6 DNA topoisomerase n=13 Tax=Bacteroidales RepID=A6L0J6_BACV8 Length = 590 Score = 182 bits (463), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 175/633 (27%), Positives = 281/633 (44%), Gaps = 78/633 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + ++P++ R IA VL RK +G++ GNG +VTW G++L A P DS AR Sbjct: 1 MIAIVTDRPNVGREIARVL-GAGRKENGYM-TGNGYMVTWTYGNMLSLAMPK--DSGTAR 56 Query: 61 WNLADLPIVPEK------------WQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREG 108 DLP++P W P + QL VI + L+ I+ A D REG Sbjct: 57 VEREDLPLLPPSVLTVRHVKTDTGWN--PDINAVLQLKVIAKVLNACDTIIAATDASREG 114 Query: 109 QLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA 168 ++L + +L +Q R I+ L +A+ + L F L ++A +R RA Sbjct: 115 EMLFRHLYGFLGC----KQPCLRLWISSLTDEAITEGMANLLPCDRFDNLFLAADSRNRA 170 Query: 169 DWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 DWL G+N + A + + G+ G S+GRVQTPVL + RR E EN + D + V I Sbjct: 171 DWLLGVNSSHA---ICKAVGF-GNNSLGRVQTPVLAEICRRYRERENHMPADSWPV--FI 224 Query: 229 VTPADERFTAIWQPS------EACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 ++R + EA Y+D + + + A +T+ + Sbjct: 225 SLCKNDRILKMRHVDDLVARREALALYEDCK----------------AAKNARITAVRKR 268 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 E AP ++L+ LQ +A + GL+A V +I Q LYE +LI+YPR+ R LP + + Sbjct: 269 TEEIGAPALYNLAELQKDANRYHGLTAIQVQEIAQSLYE-KRLISYPRTSSRLLPGDVYD 327 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 VM + +VD + HHAII T L E +V Sbjct: 328 TLPPVMEKMLSRKEFRQYAGMVDLAAPQDSIGAQDTMEHHAIIITGIQPG-KLGREEMQV 386 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE--END 460 Y LI + L F P ++ A KF + + E GW LG ER+ Sbjct: 387 YTLIVGRVLETFMPPCKVEYTTVDAVCAARKFRIRTYRILEKGW---LGIFEREHIVAKG 443 Query: 461 GTPLPVVAK--GDELLCEKG-EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 P P++ + +E+L G ++ +++ P +TD L+ M DK Sbjct: 444 CMPCPMLPEFFQEEILPVAGCSLIHKKSLPVSPYTDEELVDYM--------DK------- 488 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWES 576 GLGT +TR I+ L +R ++ G+Y+ T G L+ ++ M +T+ WE+ Sbjct: 489 --AGLGTVSTRTNILRTLLERKYIRYSGKYVVPTPKGLFLYETVRGMKVADASLTSGWET 546 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT 609 L +I + ++F+ ++ T+ ++ + R Sbjct: 547 ELARIERGELSQEEFLDGVLETVNEVTGEIFRN 579 >UniRef50_A8VW06 DNA topoisomerase n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VW06_9BACI Length = 340 Score = 181 bits (460), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 114/326 (34%), Positives = 174/326 (53%), Gaps = 23/326 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIE---CGN---GQVVTWCIGHLLEQAQPDAY 54 M+L IAEKP +A P +K FI C + G VVTW +GHL E P+ Y Sbjct: 1 MQLIIAEKPDQGAKLA--APFNPQKKKNFITIPACSHFPEGAVVTWAVGHLCELVPPEHY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLV 112 S + W++ LPI+PE+++ Q K IK F+H+ + I+HAGD +REG+ ++ Sbjct: 59 RSEWKTWSMDTLPILPEEFRFQVIKGKGKAFQTIKSFIHDQDITGIIHAGDAEREGEAII 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L ++ V+R I+ L P AV+ L + + L AL+R+ ADWL Sbjct: 119 RMILH----QARNQKPVKRLWISSLTPDAVKEGFSALLDSIDTDHLYDEALSRSFADWLV 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 GIN +RAYT+ + G V S GRVQTP L L+V+R+ EI+ FV+K F+EV A + Sbjct: 175 GINASRAYTLQFKKHGINDVYSTGRVQTPTLALIVKRENEIDEFVSKPFWEVHA-TFSHE 233 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + A+W ++D + RLL+ +AE + + +PA + K+++ AP F Sbjct: 234 QGSYGAVW--------HKDGDSRLLNSVMAERIQAFCTNRPARILDQRVKQKAIPAPSFF 285 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQK 318 +LS+LQ KR+ + + L C K Sbjct: 286 NLSSLQAAMNKRYNIFTKAHLGDCSK 311 >UniRef50_D1NG17 DNA topoisomerase (Fragment) n=3 Tax=Haemophilus influenzae HK1212 RepID=D1NG17_HAEIN Length = 299 Score = 181 bits (459), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 89/137 (64%), Positives = 109/137 (79%), Gaps = 9/137 (6%) Query: 212 EIENFVAKDFFEVKAHI-------VTP--ADERFTAIWQPSEACEPYQDEEGRLLHRPLA 262 +IE+F KDFFEV+A + TP + F+A+WQPS+ACE YQD++GR+L + LA Sbjct: 163 QIEHFQPKDFFEVQAWVNPDNKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLA 222 Query: 263 EHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET 322 E+VV RI+ QPA VT Y D RE E+APLP+SLSALQI+AAKRFG+SAQ VLD CQ+LYET Sbjct: 223 ENVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQAVLDTCQRLYET 282 Query: 323 HKLITYPRSDCRYLPEE 339 H+LITYPRSDCRYLPEE Sbjct: 283 HRLITYPRSDCRYLPEE 299 >UniRef50_P34184 DNA topoisomerase 1 (Fragment) n=1 Tax=Bacillus pseudofirmus RepID=TOP1_BACPF Length = 505 Score = 180 bits (457), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 135/509 (26%), Positives = 247/509 (48%), Gaps = 30/509 (5%) Query: 35 GQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKR--FL 92 G ++ +GH+LE +P + +Y ++L LPI+ + +Q + + L IK F Sbjct: 13 GALICAAVGHILEFLEPGELNEKYKSYSLDSLPIIIDLFQYKVVSDKKEVLQRIKDTIFD 72 Query: 93 HEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSN 152 I+ A D EG+ + +L L ++ ++R + + ++++A +L+++ Sbjct: 73 KRVKTIILATDAAAEGEYIGRNILYRLHC----KKTIKRLWTSSMTAFSIQKAFSQLKAD 128 Query: 153 SEFVPLCVSALARARADWLYGINMTRAYTILGRNAG---YQGVLSVGRVQTPVLGLVVRR 209 +E +PL A ARA +D++ G+ ++RAY IL + G + +S+GRVQTP+L +V+R Sbjct: 129 AETLPLYYQAKARAESDYMIGLTLSRAYGILLKEQGIVPHNTTISLGRVQTPLLAEIVKR 188 Query: 210 DEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI 269 + +E F A++F+ VKA + + W + ++E R+ E + + Sbjct: 189 ERLLEQFTAENFWTVKATFNNQGN-VYEGEW--------FHEKENRIFTEEQDEQLCELV 239 Query: 270 SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 Q + + ++ + PL + LS LQ++A FG L Q LY+ L +YP Sbjct: 240 RNQSSTIMEMKEEMRTYQPPLLY-LSTLQMDAGNAFGFKPAETLKYAQSLYDKGYL-SYP 297 Query: 330 RSDCRYLPEEHFAGRHAVMNAISVH--APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 R+ + E + +S H + L P P V + N+ + + D H +I Sbjct: 298 RTQDERITESDARELENNIQFLSGHDTSGALFPLP-VSTLMNNKRYIGEVTDHHALLITD 356 Query: 388 ARSSAINLTENEAKVYNLIARQYLMQFCPD-AVFRKCVIELDIAKGKFVAKARFLAEAGW 446 +L+E+E +Y+L+ ++ L PD A+ K +I + + F +K + L G Sbjct: 357 KIPKDKDLSEDEKSIYHLVVKRILAAHYPDVAMSHKEIITKVMDRFTFRSKGKELLSKGR 416 Query: 447 RTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 ++ END LP + KG E + + +T+PP +T ++L+ M A+ Sbjct: 417 HHIIPPT---NEND-IMLPTLLKGSEGVVTDTLTTKSKTKPPNRYTSSSLIGFMKNAAQA 472 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELL 535 ++D+D K I + LGTEATRAG+ L+ Sbjct: 473 IEDEDRKSI--SNLPLGTEATRAGLTHLV 499 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 179 bits (455), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 182/666 (27%), Positives = 312/666 (46%), Gaps = 73/666 (10%) Query: 3 LFIAEKPSLARAIADVLP--KPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPDAY 54 L IAEKP++AR IA L +P RK G F G +V +GHL A P Sbjct: 4 LIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLA-PKTK 62 Query: 55 DSRYARWNLADLPI-VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVD 113 Y +++ +P+ V EK + + + + KR A E V A D D EG+++ Sbjct: 63 TYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKR----ADEFVVACDYDTEGEVIGY 118 Query: 114 EVLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 L Y + P K +R + L + + +A L S F + + +AR DW + Sbjct: 119 TALKYACGVDPSK---AKRMKFSALTKKDLLKAWYNLESTINF-GMADAGIARHVLDWYW 174 Query: 173 GINMTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N++RA T + R +G VLS GRVQ P L +V R++EI+NF ++ +K ++ Sbjct: 175 GVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIK-MVLEK 233 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 +++TA++ E+ R+L A+ +V PA V + K+++ P+P Sbjct: 234 NGQQYTAVY-----------EKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVP 282 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F L LQ EA FG S + L++ QKLYE L +YPR+ + LP ++ R + N Sbjct: 283 FDLGTLQREAYSAFGYSPKKTLELAQKLYE-RGLTSYPRTSSQKLP-KNLNFRSILQNLA 340 Query: 352 SV-----HAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTAR-SSAINLTENEAKVYN 404 + A +LL + + P + KK D AH AI PT LT++EA +Y+ Sbjct: 341 KLPEYKPFAHELLGKERLKP------VEGKKDDPAHPAIYPTGELPKPGELTKDEANLYD 394 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 LI R++L F AV + ++ +F+ + GW + G + +E L Sbjct: 395 LIVRRFLALFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDE---AIL 451 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P +G+ + + + +++T+PP ++ A ++ M +DL G+GT Sbjct: 452 PAFKEGEPVKVLQIKREKKKTKPPARYSPAAVIKRM---------EDL--------GIGT 494 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWESVLTQ 580 +ATRA I+E L+ RG++ K + I T G +AL ++P++ + ++T +E + + Sbjct: 495 KATRAQILETLYSRGYIEGKKK-IKVTPLGMRVVEALERNVPDIVS-VELTRAFEEKMEE 552 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 I + ++ L +++ Q K + + ++ G K+ A R + K+ Sbjct: 553 IMAGKADKDRVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKE 612 Query: 641 SPPADE 646 +E Sbjct: 613 LSETEE 618 >UniRef50_D1K8I7 DNA topoisomerase n=1 Tax=Bacteroides sp. 3_1_33FAA RepID=D1K8I7_9BACE Length = 647 Score = 177 bits (448), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 157/535 (29%), Positives = 246/535 (45%), Gaps = 50/535 (9%) Query: 79 PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLN 138 P +QL VI+ L EA + A D REGQL+ + YL + + +R ++ L Sbjct: 33 PVAVRQLEVIRGLLREADGAITATDTSREGQLVARNLYGYLGF----KGKTERLWLSSLT 88 Query: 139 PQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRV 198 A+ A LR +S + L ++ AR AD + G N + A LG AG + S+GRV Sbjct: 89 DNAICEAFFDLRPDSLYEGLYLAGRARREADRIIGYNASLA---LGMAAGKKN-HSLGRV 144 Query: 199 QTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER-FTAIWQPSEACEPYQDEEGRLL 257 QTPVL L+ RR E +F A ++ ++ ++ E FT E Y E + Sbjct: 145 QTPVLALISRRYLENRDFTAVPYYRLELSVLKEGKELVFTCP-------EKYTRREDAVA 197 Query: 258 HRPLAEHVVNRI-SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDIC 316 R NRI + + + K E PL + L++LQ EA R GL+A I Sbjct: 198 AR-------NRIPASRVTTIIQVERKGTVEEPPLLYDLASLQKEANLRTGLTAGQTASIL 250 Query: 317 QKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL--PQPVVDPDIRNRCWD 374 Q+LYE I+YPR+ CR++ E+ A+++ + + P L + + + D Sbjct: 251 QRLYE-EGYISYPRTSCRHIREDMLEKMSALLSLLKDN-PRLARHAEALEGKALSTHAAD 308 Query: 375 DKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKF 434 D KV HHAII T S L +E +Y +IA + L F + + L+ +F Sbjct: 309 DGKVSGHHAIIIT-ESVPGKLPLDEQIIYWMIAGRMLEAFSDACTGEEVNVSLECGGIRF 367 Query: 435 VAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDA 494 A R AGW+++ G ++E+ T P + L V +T P FT+A Sbjct: 368 GAGYRRRVHAGWKSVYGEAGKEED---TVFPSWEPDEVLPVTDISVRSVETFPEPLFTEA 424 Query: 495 TLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG 554 +LLS M GLGT +TRAG+IELL R ++ ++G Y+ T G Sbjct: 425 SLLSEMERC-----------------GLGTPSTRAGVIELLIARRYVERQGCYLLPTPKG 467 Query: 555 KALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 ++ ++ ++ P+MTA WE L +I F+Q + Q++++ + Sbjct: 468 LEVYEAVRDKLIAAPEMTARWEKDLLEIERGGLDADVFIQKVEEYARQIVEELSK 522 >UniRef50_C3WQ11 DNA topoisomerase n=4 Tax=Fusobacterium RepID=C3WQ11_9FUSO Length = 803 Score = 176 bits (445), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 163/655 (24%), Positives = 285/655 (43%), Gaps = 95/655 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPH---RKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS-R 57 RL IAEKPSL RAIA+ L K +G+ E + +VTWC GHL + YD Sbjct: 4 RLIIAEKPSLGRAIANALNVKKFTGEKSNGYYE-NDKYIVTWCFGHLFKLKDIGDYDGLN 62 Query: 58 YARWNLADLPIVPEKWQLQPRPS--------VTKQLNVIKRFLH--EASEIVHAGDPDRE 107 W LP +P ++L+ P + KQ+ +IK + + EI+H GD DRE Sbjct: 63 NINWKDIALPFLPNPFELKYNPGRTEEEGEGIKKQVEIIKELVSKDDIDEIIHCGDADRE 122 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 GQ++V+EVL+Y+ +++V R + + +++ I + NS + L L R Sbjct: 123 GQVIVNEVLEYIG----NKKKVTRLWLPEQTEDTIQKQIMNCKENSTYNDLYNEGLTRIY 178 Query: 168 ADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV--- 224 DW GIN++ ++ + L++GRV P++ + R++ I+NF + +F++ Sbjct: 179 MDWFLGINLSVFLSVKAKTK-----LNIGRVLIPIVKYIYDREQAIKNFKVEKYFQLESK 233 Query: 225 --KAHIVTPA---DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSY 279 K +I P E+F++ + AE V ++ A V S Sbjct: 234 TEKENIKIPLILRKEKFSS--------------------KEEAEKVAKELNNNKAKVVSI 273 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K + F+L LQ +K+ + + I QKLYE ITYPR+ YL +E Sbjct: 274 EKKEVKKFPKKLFTLGELQSTLSKKHKMIFKRSEAITQKLYE-EGYITYPRTSIPYLSDE 332 Query: 340 HFAGRHAVMNAISVHAPDLL---PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT 396 ++N I+ +L + + D + K +H A+ PT + L+ Sbjct: 333 EKDRVKDLINLINQKGYNLEFKDSKKIFDSSKFGSSETESK--SHSALTPTLKLPE-KLS 389 Query: 397 ENEAKVYNLIARQYLMQF-CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKER 455 + E VY +I +++ F + + + + + +A +F K + + G+ T K Sbjct: 390 KEEEIVYQVIFNRFVANFLVEETIVSETTLTMKVADKEFKLKGTEIIKPGFYTYEPKKFD 449 Query: 456 DEENDGTPLPVVAKGDELLCEKGEV----VERQTQPPRHFTDATLLSAMTGIAR------ 505 ++ LP + + +E EV ++++T+PP+ T++ L + + R Sbjct: 450 NQ------LPNLIENEEF-----EVNFLAIQKETEPPKKVTESELGNYLEHPFRKEIKEK 498 Query: 506 ----------FVQD-KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG 554 +D +D K IL + +GT ATR GII G++T++ T G Sbjct: 499 NNEDEENEEEITEDAEDYKNILEGIE-IGTVATRTGIISNAESYGYITQENSNYSITSKG 557 Query: 555 KALFHSLPEMATR--PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + L L E+ + T + L ++ D + L ++I+ K Sbjct: 558 EKLIQLLDELKINLYKERTIEFSKDLKKVFHNMKTIDDVLGNTWNVLNEIIENGK 612 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 171 bits (434), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 174/631 (27%), Positives = 302/631 (47%), Gaps = 75/631 (11%) Query: 1 MRLFIAEKPSLARAIADVLP--KPHRK---GDGFIEC---GNGQVVTWCIGHLLEQA-QP 51 M L IAEKP++AR IA L +P +K G + E G +V +GHL A + Sbjct: 1 MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKR 60 Query: 52 DAYDSRYARWNLADLPI-VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQL 110 D + Y +++ +P+ + EK + R + K L+V+ + E + A D D EG++ Sbjct: 61 DVFG--YPIFDIEWVPVYIAEKGKEYAREYI-KALSVLAK---RVREFIVACDYDTEGEV 114 Query: 111 LVDEVLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 + L Y + P + +R + L + + A L F + + +AR D Sbjct: 115 IGYTALKYACGVDP---RVAKRMKFSALTKRDLLNAWRNLEPTINF-GMANAGIARHILD 170 Query: 170 WLYGINMTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 W +G+N++RA T + + +G VLS GRVQ P L +V R+ EI++FV + ++ +K I Sbjct: 171 WYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKL-I 229 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 ++FTA ++ + +++EEG+ +V + V++ KR+ + Sbjct: 230 FEKNGQKFTANYEKDKI---WEEEEGK--------RIVLEVKKSIPRVSNVEIKRQKRTP 278 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 P PF L LQ EA FG S + LDI Q LYE +YPR++ + LP + R + Sbjct: 279 PHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKG-FSSYPRTESQKLP-RNINFRMIIQ 336 Query: 349 NAISV-----HAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTAR-SSAINLTENEAK 401 N + +A LL P + P + KK D AH AI PT +LT++E K Sbjct: 337 NLAKMPQYRPYAHILLGLPELKPV------EGKKEDPAHPAIYPTGEIPRPGDLTKDEEK 390 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 +Y++I R++L F A+ + + KF + GW ++ G + EE Sbjct: 391 LYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEE--- 447 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 LP G+ + + + +++T+PP ++ A ++ M +DL G Sbjct: 448 VTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKM---------EDL--------G 490 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWESV 577 LGT+ATRA I+E L++RG++ K + I T G + +L PE+ + ++T +E Sbjct: 491 LGTKATRAQILETLYQRGYIEGK-KSIKVTPLGMKVIETLEKYVPEIIS-VELTREFEKK 548 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 + I E + ++ ++ L +++++ K+ Sbjct: 549 MELIMEGRLTKEEVIEEAKERLTKILEEFKK 579 >UniRef50_Q8CM28 DNA topoisomerase n=1 Tax=Streptococcus agalactiae serogroup III RepID=Q8CM28_STRA3 Length = 582 Score = 170 bits (431), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 169/618 (27%), Positives = 289/618 (46%), Gaps = 86/618 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFI-----ECGNGQVVTWCIGHLLEQAQPDAYDSR 57 + +AEK + A A A+ L +KG I + V GHL E P Sbjct: 4 VILAEKETQAAAYAESLGPASKKGKVHIIKHTPYFSDEVHVIAAEGHLFEYGLPKD---- 59 Query: 58 YARWNLADLPIVPEKW-QLQPRPSVTKQLNVIKRFLHE---ASEIVHAGDPDREGQLLVD 113 W+L LP+V + Q + V+K+ + K+ E A +++ D DREG+ + Sbjct: 60 --NWDLDKLPLVDVSFKQTLKQDKVSKE--IFKQIYQEVTAADQVIIGTDSDREGERIAY 115 Query: 114 EVLDYLQLAPEKRQQV-QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L ++ PE + +V +R +N L +A+++A LR E + A ARA++DWL Sbjct: 116 SILSHI---PEGKNKVTKRLWVNSLTTRALQKAFQNLREPIETYNYYLEAEARAQSDWLV 172 Query: 173 GINMTRAYTI----LGR-NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAH 227 G+N++ T+ GR G LSVGRVQTP + L+ D I+NF + +++++ Sbjct: 173 GMNLSPLVTLELQKRGRLPKGKGNSLSVGRVQTPGVRLICENDLAIQNFRPETYWKLQLQ 232 Query: 228 IVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 ++ T I ++ E Y D E L + + +IV+S + + + Sbjct: 233 ------DKETEISFSNK--EKYSDSELILAQARQLKAI--------SIVSSVEMEEKQRA 276 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF------ 341 AP F+LS +Q AAK++G + + LY K ++YPR+D R++ EE F Sbjct: 277 APHLFNLSDIQGLAAKQWGFEPTKTERLIESLY-LKKYLSYPRTDTRFITEEEFDYLKNY 335 Query: 342 -AGRHAVMNAISVHAPDLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTEN 398 V+N S A +L P + V+P+ + +H+A+IPT + + L + Sbjct: 336 LKSYQEVINC-SFEAVNLEPRENYVNPEKVAKT-------SHYALIPTENIPNLVTLKPD 387 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 E +Y + R+ L+ F D + +E++ F R + + GW K + + Sbjct: 388 ERLIYEAVVRRTLLMFAADCRYSTTTVEVENQGLVFKTTGRQMFDPGWAAFSQQKLKGD- 446 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 LP GD++ K +VE T+PP+ T++ L+S + + ++ Sbjct: 447 ---IELPDYRVGDQIET-KVIIVEGMTKPPKRITESQLISDI--LPKY------------ 488 Query: 519 TDGLGTEATRAGIIELLFKRGFLT--KKGRYIHSTDAGKALFHSL--PEMATRPDMTAHW 574 GLGT+ATRA +++ + RG++T KK + T+ L H L E A+ P+ T W Sbjct: 489 --GLGTQATRATMLQTIQDRGYITKDKKTGQLFPTNKAYLLIHYLYDNEFAS-PETTGGW 545 Query: 575 ESVLTQISEKQCRYQDFM 592 E L+QI E + ++F+ Sbjct: 546 ELFLSQIGEGEINPREFV 563 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 170 bits (430), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 171/602 (28%), Positives = 267/602 (44%), Gaps = 73/602 (12%) Query: 1 MRLFIAEKPSLARAIADVLPK-PHRKGD-------GFIECGNGQVVTWCIGHLLEQAQPD 52 MRL I+EK + AR IA L + P ++G F G V GH+L P+ Sbjct: 1 MRLIISEKANAARKIAQFLAEGPVKEGKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYPE 60 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQ--LNVIKRFLHEASEIVHAGDPDREGQL 110 Y + W D + + L+ SV+++ ++ +A ++ A D DREG+L Sbjct: 61 EYSN----WQKVDPRELIDARILK---SVSEKGVAAAVRSLAKKADRVIIATDFDREGEL 113 Query: 111 LVDEVLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 + E L + P V+R + L V RA + L S L + AR D Sbjct: 114 IGVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSR--ELADAGEARQDID 171 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 ++G +TR + + G LSVGRVQ+P L L+ R+ E FV + ++EV+A + Sbjct: 172 LIWGATLTRWVSRAVKRYG-SAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQ 230 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 F A + GR A + +S + A+VT + + AP Sbjct: 231 NGGGP-FVA-----------RHARGRFKEEAEARRALENLS-ETAVVTEVRQREATRPAP 277 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE----HFAGRH 345 PF+ +A + AA G+S I + LY T I+YPR+D PE G Sbjct: 278 APFNTTAF-LTAAANIGVSPSRAARIAEDLY-TEGYISYPRTDNTVYPESLDLREVLGFL 335 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 A + + +A LL + P R R ++ H I PT R+S L E++ K+Y L Sbjct: 336 AEVEGVGDYAGRLLGAGRLTP-TRGR----RQTTDHPPIYPTGRASRAELREDQWKIYQL 390 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG-SKERDEENDGTPL 464 + R++L A + + + VA + E GW + + RDEE L Sbjct: 391 VVRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE-----L 445 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P +++GDE+ + E++ ++TQPP + L+ M +DL GLGT Sbjct: 446 PRLSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLM---------EDL--------GLGT 488 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQI 581 +ATR GII+ L+ RG++ G I T+ G A+ +L + A+ +MTA E + I Sbjct: 489 KATRPGIIQNLYDRGYI--HGDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAI 546 Query: 582 SE 583 SE Sbjct: 547 SE 548 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 169 bits (428), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 164/618 (26%), Positives = 276/618 (44%), Gaps = 100/618 (16%) Query: 3 LFIAEKPSLARAIADVLP----KPHRKGDG----FIECGNGQVVTWCIGHLLEQAQPDAY 54 L IAEK + A+ IA +L + +KG F + + V GH+L PD Sbjct: 21 LVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPD-- 78 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQ--LNVIKRFLHEASEIVHAGDPDREGQLLV 112 ++ RW+L DL + ++ +P + ++ N+++ +A ++ A D DREG+L+ Sbjct: 79 --KFKRWSLGDLQRLVDE---EPIKIIKEKGIANILRTLAKDADMLIIATDYDREGELIG 133 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 E L + V+R + L + +E A L + L +A R + D + Sbjct: 134 VESLSITNF----KGPVKRAKFSALTEREIENAFSNLVDVN--YNLASAAETRQKIDLAW 187 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA------ 226 G ++TR ++ G + LSVGRVQ+P L L+V+R++EIENFV ++ +K Sbjct: 188 GASLTRFISLASSRRG-KDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRR 246 Query: 227 -----HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYND 281 HI P W+ E E Y+ + + A V + Sbjct: 247 NFSGMHISNP-------FWKEEEVMEVYEKVK----------------DTKSAKVLDFVQ 283 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 + P+PF+ + EA K G SA + + ++LY I+YPR+D P Sbjct: 284 EDRKIRPPIPFNTTEFLSEATK-LGFSAAKAMRLAEELY-MGGYISYPRTDNTVYP---- 337 Query: 342 AGRHAVMNAI--SVHAPDLLPQPVVDPDIRNR--CWDDKKVDAHHAIIPTARSSAINLTE 397 + +N+I S+ + + R R K+ H I+PT NL Sbjct: 338 --KTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPT---RGANLEG 392 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE 457 ++ K+Y L+ R+++ D +R+ ++L + F AK + L GW +E Sbjct: 393 DKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEE 452 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E +P++ GDE+ +K E+ ++T+PP +T ++L+ M + Sbjct: 453 EK----IPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKL-------------- 494 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHW 574 LGT++TRA II+ LF+RG++ +G I T GKAL SL +PDMTA Sbjct: 495 ---NLGTKSTRAEIIQKLFERGYV--RGNPIRPTQLGKALIESLEGNNVDVIKPDMTARL 549 Query: 575 ESVLTQISEKQCRYQDFM 592 E + +I EK + +F+ Sbjct: 550 EMDMDEI-EKGSKAPEFV 566 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 167 bits (424), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 170/624 (27%), Positives = 287/624 (45%), Gaps = 75/624 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKG-DG--FIEC---GNGQVVTWCIGHLLEQAQPDAYDS 56 L I EKPS+A+ IA+ L K +K DG + E G +V +GHL + + + Sbjct: 8 LIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKE--NK 65 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + + + D+ VP + + V K + +K+ +A E A D D EG+L+ L Sbjct: 66 EFGFYPVFDIKWVPASVD-KGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHAL 124 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y R++ +R + L + + RA + + L + +R DW +GIN+ Sbjct: 125 KYCC----GREKAKRMRFSSLTKKEIVRAFEN--PDEIDYGLVDAGESRHILDWYFGINL 178 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RA R +SVGRVQ P L + R+ EI+ F+ K ++ ++A + + Sbjct: 179 SRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALL----KDNL 234 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSL 294 AI E+ + + A++V +I + + +V KR+ + P PF L Sbjct: 235 KAI-----------HEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLP-PFDL 282 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 LQ EA F +S + +I QKLYE + LI+YPR+ + LP++ ++N I H Sbjct: 283 GTLQREAYSYFKISPKETQEIAQKLYE-NALISYPRTSSQKLPKDR-KYLEDILNIIKNH 340 Query: 355 ------APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 A +L + + + + KK D H I L+E E ++Y+LIAR Sbjct: 341 PVYGKWAERILKENL-------KPVEGKKEDPAHPAIHIVDIPKEELSEKEKEIYDLIAR 393 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + L F +A +++DI KF + GW + + DE LP + Sbjct: 394 RTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDE----IELPPLK 449 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 K D + EK + ++TQPP+ +T A+++ K+L+K GLGT+ATR Sbjct: 450 KNDIIKVEKITITRKETQPPKRYTVASII------------KELEK-----RGLGTKATR 492 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWESVLTQISEK 584 A II+ L KRG++ G + TD G ++ +L PE+ MT E L +I + Sbjct: 493 AEIIDKLIKRGYVIDDGS-LKVTDLGISVIETLKRFCPEIIDE-KMTRDLEEKLEKIQFR 550 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKR 608 + + D + L +++++ K+ Sbjct: 551 KIKKDDVLDEAEKRLRKILEEFKK 574 >UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41D8C Length = 741 Score = 166 bits (421), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 176/667 (26%), Positives = 285/667 (42%), Gaps = 93/667 (13%) Query: 3 LFIAEKPSLARAIADVL-PKPHRKGDG-------FIECGNGQVVTWCIGHLLEQAQPDAY 54 + I+EKP A IA L P +K F E G V +GHL + Sbjct: 4 VIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSR 63 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 D R DL VP ++++ + +N IK+ A + VHA D D EG L+ Sbjct: 64 D----RLGF-DLTWVPA-YEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYN 117 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L Y + R + L + + A + +R + +AR D+ YG+ Sbjct: 118 ALKY-ACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDID--IRQVDHGIARHMLDYYYGM 174 Query: 175 NMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 N++ A R + + + LS GRVQTP L ++V R++EI++FV + ++ +KA +D Sbjct: 175 NISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAK----SD 230 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 A EG++ A+ + G A VTS P+PF+ Sbjct: 231 YDIIA-----------DHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFN 279 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L LQ EA FG S + Q LY +YPR+ + LPE S+ Sbjct: 280 LGGLQSEAHTVFGFSPKRTQVAAQNLY-VGGYTSYPRTSSQKLPE-------------SL 325 Query: 354 HAPDLLPQPVVDPDIRNRCWD---------DKKVDAHH-AIIPTARSSAINLTENEAKVY 403 ++ DP+ + +D KK DA H AI PT + NL+ +EAK+Y Sbjct: 326 DFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPS-NLSADEAKIY 384 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +LI +++ F ++ + L +A KF + ++ GW L + +END Sbjct: 385 SLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGW--LKHYPFKKQENDA-- 440 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 P + KGD+L K V E++T+PP + +A+L+ K+L+K LG Sbjct: 441 FPPINKGDQLKIHKILVEEKETKPPARYNEASLI------------KELEK-----RELG 483 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQ 580 T+ATRA I+ L+ R ++ +G+ I G + +L E T ++T +E L Sbjct: 484 TKATRADIVAKLYDRKYI--EGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEG 541 Query: 581 ISEKQCRYQDFM---QPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGGSADKKKA 631 I + + + + V T+ I+Q K+ + G +V S G K+ Sbjct: 542 IDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRY 601 Query: 632 APRKRSA 638 +PR ++ Sbjct: 602 SPRTKNT 608 >UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=TOP1_ARCFU Length = 663 Score = 163 bits (412), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 170/618 (27%), Positives = 279/618 (45%), Gaps = 82/618 (13%) Query: 3 LFIAEKPSLARAIADVL---PKPHRKG--DGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 L I EK + AR IA +L K +KG + N V GH++E P ++ Sbjct: 6 LIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKELNN- 64 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W L + + +L + +++K +A + A D DREG+L+ E L+ Sbjct: 65 ---WTKTPLEKLLQA-ELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALE 120 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++ + +V R + + + + A + +F L +ALAR + D ++G +T Sbjct: 121 IVK-SVNPTVKVDRVRYSAVTEKEIRSAFSK-PVKVDF-NLANAALARQKIDLIWGATLT 177 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R ++ G + LSVGRVQTP L L+V R+ EI+NF + ++E+ A E F Sbjct: 178 RLISVHSGRMG-KDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEF-----EGFI 231 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A R + AE + +I G+ A V + +R E+ P PF+ + Sbjct: 232 A------------KHPKRYGSKEEAEKLFAKI-GETAKVEEFTRRRMEENRPTPFNTTEF 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 EA+K +S ++I + LY + I+YPR+D P +++A+S P Sbjct: 279 LREASK--FMSPHKAMNIAETLY-MNGYISYPRTDNTVYPPT--INLIEIVSALSSVFPR 333 Query: 358 ----LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 +L Q + P R D H I PT + L+++E +Y L+ R++L Sbjct: 334 EAQIVLSQDKITPSRGRRETKD-----HPPIYPTGVAKRGELSKDEWTIYELVVRRFLAT 388 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 P AV+ + LD KFVA R L EAGWR + + +E T LP++ KGD L Sbjct: 389 LAPKAVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAEE----TELPLLKKGDVL 444 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 K + E++T+PP ++ ++L+ M + LGT++TR II+ Sbjct: 445 RILKKRLEEKETKPPGRYSASSLIKMMEKL-----------------NLGTKSTRHEIIQ 487 Query: 534 LLFKRGFLTKKGRYIHS-----TDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 L R RYIH ++ ++ + L E A T PDMTA E+ + I+E + Sbjct: 488 KLVSR-------RYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGK 540 Query: 586 CRYQDFMQPLVGTLYQLI 603 R + + L Q++ Sbjct: 541 KREPEVVDESREMLLQIL 558 >UniRef50_Q0W2I3 DNA topoisomerase I n=2 Tax=Euryarchaeota RepID=Q0W2I3_UNCMA Length = 767 Score = 162 bits (409), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 162/620 (26%), Positives = 271/620 (43%), Gaps = 65/620 (10%) Query: 1 MRLFIAEKPSLARAIADVLPK---PHRKGD--GFIECGNGQVVTWCIGHLLEQAQPDAYD 55 M L I EK A IA +L K P R + +V GH+LE P+AY Sbjct: 1 MHLIITEKHDAASKIAAILFKDRTPERINGVPAYRSKAADALVIGLAGHILELDFPEAYQ 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 +W+ A P + Q+ PS + + + + + A D DREG+++ E Sbjct: 61 ----KWS-AFPPRELIRAQVVTYPSKKDLVGALATLATKVTRVTIATDYDREGEMIGVEA 115 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + ++ R + + + +A + L + R D ++G Sbjct: 116 YNIIKKI--SSPTFDRVRYSSFTKEEITKAF--ASPTAVDFDLAAAGECRQEIDLVWGAA 171 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 +TR +I G G + LSVGRVQTP+L L+V R++EI+ F +K ++E+ A ++ D Sbjct: 172 LTRFVSIAGNKFG-KDFLSVGRVQTPLLALIVDREKEIQAFTSKPYWEIVATLLK-EDRS 229 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 FTA + + EE +H+ L G+ A+V R+ E P+PF+ + Sbjct: 230 FTASHKRGRF---DKKEEAAAIHKKL---------GKTAVVKDVKADRKKEQPPIPFNTT 277 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE----EHFAGRHAVMNAI 351 ++AA G +A + + I + LY + I+YPR+D P+ + G Sbjct: 278 EF-VKAASALGFTAASAMQIAEALY-INGWISYPRTDNTVYPDTLNLKDLLGIFKTSPDF 335 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 + A +LL P + P R + + H I P A + +L + + K+Y L+ R+Y Sbjct: 336 AKSALELLAMPSITP-TRGKV----ETKDHPPIYPVACAMRKDLDDRQWKLYELVVRRYF 390 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 P + E+DI+ F A + LA GWR + +E LP + GD Sbjct: 391 ATLSPACEWETIKAEIDISGEPFAANGKQLAVPGWRKHYPYGLQKDEL----LPPLKAGD 446 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 LL K +++E++T+PP+ + L+ M +DL GLGT+ATR Sbjct: 447 PLLVRKADLLEKKTEPPKRYGQGKLVQMM---------EDL--------GLGTKATRHEA 489 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRY 588 + L++RGF+ +G T G +L +L A T MT+ E + I+ Q + Sbjct: 490 LAKLYQRGFI--EGNPPQPTATGISLIDALKAYASAITSNAMTSKLERDMDAIAASQLKK 547 Query: 589 QDFMQPLVGTLYQLIDQAKR 608 + L ++ DQ ++ Sbjct: 548 AAVAKESREMLDKVFDQLEK 567 >UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DGI7_9EURY Length = 727 Score = 162 bits (409), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 177/611 (28%), Positives = 265/611 (43%), Gaps = 93/611 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKG--DGFIEC-----GNGQV-VTWCIGHLL---EQAQP 51 L IAEKPS+A IA L K +G I G+G++ V +GHL ++ + Sbjct: 4 LIIAEKPSVALRIAIALGNGQHKSVRNGRITYYTMPHGDGEIYVAAAVGHLFTIRQKGKE 63 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQ-LNVIKRFLHEASEIVHAGDPDREGQL 110 AY W + L R TK+ L +K+ E S ++A D D EG + Sbjct: 64 RAYPITEIEWAPSYL--------TNKRSEYTKEYLFTLKKLAQECSTFINACDYDIEGTV 115 Query: 111 LVDEVLDYLQ-LAPEKRQQV-QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL----A 164 + ++ L L E V +R + P+ D L S +P ++ A Sbjct: 116 IGTNIIKELSGLQAEAIGSVSKRMKFSTTTPK------DLLDSFGSLLPPDINNFYAGEA 169 Query: 165 RARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 R DWL+GIN +RA T ++G LS+GRVQ P LGL+ +R++EI +F + ++ V Sbjct: 170 RHMLDWLWGINFSRALTSALSSSGQYKQLSIGRVQGPALGLLAKREKEIASFKPEPYWNV 229 Query: 225 KAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKR 283 A+ F I + G + + AE + SG+ V S Sbjct: 230 LAY-----SGEFEFI-----------NSRGNIFAKQEAESAFSAANSGRDNAVVSEATSA 273 Query: 284 ESESAPL-PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE--- 339 E P PF L++LQ+EA++ FG L + Q LYE I+YPR+ + LP Sbjct: 274 EQLRRPYPPFDLTSLQLEASRVFGFDPSATLAMAQSLYE-RSFISYPRTSSQKLPRTLGL 332 Query: 340 -HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTEN 398 A S A ++ + P K+ +AH AI PT + +T + Sbjct: 333 PRIIADLGKNPAYSTIAAEIASKGRFTP-----AEGPKEDEAHPAIFPTGVTPK-GITGS 386 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS---KER 455 E K+Y+LIAR++L F A +E+ I F K + GW KER Sbjct: 387 EEKLYDLIARRFLSCFGEYAKVNNFSLEISIGGETFEGKGSKVTYPGWLDYYKYAKIKER 446 Query: 456 DEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 D LP + KG + ++ E QT PP+ FT A L+S +L+K Sbjct: 447 D-------LPNLEKGQRVEITDIKMPELQTAPPKRFTKAGLIS------------ELEK- 486 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTA 572 LGT+ATRA II+ LFKR ++ +G I T+ G ++ +L + M D T Sbjct: 487 ----HNLGTKATRAAIIDTLFKRNYI--EGSSIRVTEFGMTVYDALEKNCSMIVDEDTTI 540 Query: 573 HWESVLTQISE 583 E + IS+ Sbjct: 541 TLEKDMDLISK 551 >UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales RepID=A7I6L6_METB6 Length = 942 Score = 161 bits (407), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 154/623 (24%), Positives = 274/623 (43%), Gaps = 75/623 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHR----KGDGFIECGNGQVVTWCI-GHLLEQAQPDAYD 55 M L +AEK A IA +L R K G G +T + GH++E Y+ Sbjct: 1 MHLIVAEKNISAHRIAQILAGGTRVIEKKDAGVSTYSFGDTITVGLRGHVVEVDFEPGYE 60 Query: 56 S----RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 + +Y +L D + P+ + ++++++ A + A D D EG+L+ Sbjct: 61 NWRSEKYTPRSLIDAKTIKV-------PTEKRIVSLVQKLARHADRVTIATDFDTEGELI 113 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA--D 169 E + ++ A K ++ R + + Q + A +N+ + ++A AR D Sbjct: 114 GKEAYELVR-AVNKNVKIDRARFSAITAQEIGSAF----ANTTDLDFALAAAGEARQSID 168 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 ++G ++TR ++ + G +LSVGRVQ+P L ++V R++EIE FV + ++++ + Sbjct: 169 LMWGASLTRFISLAAKRGG-NNILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQL-GLLT 226 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 A E+ A + GR + AE +R + +P +VT + + + +P Sbjct: 227 EKAGEQIEA-----------RHTNGRFKDQKAAELARDR-TKEPLVVTEVREGTKQDRSP 274 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 PF + I AA R G SA N + I ++LY + I+YPR+D P +N Sbjct: 275 SPFDTTTY-IVAAARLGFSAANAMRIAEELY-MNGYISYPRTDNTVYPAS------LDLN 326 Query: 350 AISVHAPDLLPQPVVDPDIRNR----CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 + + VD I +R K H I PT ++ + ++ ++Y L Sbjct: 327 GVLATIRNSPFTKDVDWIISHRRAEPTRGKKSSTDHPPIYPTGVATREGIGDDAFRIYEL 386 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 + R++L PDA+++ + + + L E GW + E E T LP Sbjct: 387 VLRRFLATLAPDALWKTLKVNFEAGGETYTVTGGLLLEPGWHAVYPFSEAKE----TILP 442 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 G++L K + E++T PP +T + L+ M + GLGT+ Sbjct: 443 AFVTGEKLPIRKVNLEEKETLPPARYTQSKLIQRMEEL-----------------GLGTK 485 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQIS 582 +TR +I L R ++ +G + T G+ + +L + A T+P+MT ES + QI Sbjct: 486 STRHEVIARLVSRKYI--EGNPLRPTLVGRVVTEALEQNADTITKPEMTQTIESHMQQIK 543 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQ 605 E + D + L++ DQ Sbjct: 544 ESKRTRDDVIAESRSMLHKAFDQ 566 >UniRef50_UPI000185C839 DNA topoisomerase n=1 Tax=Capnocytophaga sputigena ATCC 33612 RepID=UPI000185C839 Length = 710 Score = 160 bits (406), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 171/636 (26%), Positives = 288/636 (45%), Gaps = 71/636 (11%) Query: 3 LFIAEKPS----LARAIADVLPKPH-RKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 L IAEK + ARA+ L H KGD + C GHLLE A+ AY Sbjct: 5 LIIAEKSTQMREYARALGFTLKGGHYEKGDTILSCA--------AGHLLELAEDTAYRGE 56 Query: 58 YARWNLADLPIVPE--KWQLQPRPSVTKQ--LNVIKRFLH--EASEIVHAGDPDREGQLL 111 +W+ + LP++ + ++ P+ +Q LN + L+ E I+ A D DREG+L+ Sbjct: 57 -GKWDKSYLPLLLQIKDYKYVPKKEENRQAQLNKLGSLLNSPEIGNIIVATDSDREGELI 115 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDR--LRSNSEFVP-LCVSALARARA 168 + +Y + ++ R ++ L + + A + F+ LC S AR Sbjct: 116 FRYIYNYFKC----KKPFIRVWVSALVDENIREAFAHPIYKQGDPFLENLCKSGYARTFT 171 Query: 169 DWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 DWL G+N T+A T+ G +LS+GRVQ+ +L ++ R + + K H Sbjct: 172 DWLIGVNATQAATL---QLGQGKLLSIGRVQSTILKIICDR-----------YIKNKGHE 217 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 T + I S Y E + A+ V N + + V S+ K+ S++ Sbjct: 218 KTYT---YKIITNHSYNGTTYTTESPIYESKEQAQAVFNGLLPAHSFV-SHEVKKVSKNP 273 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL +L +L I A K + + VL QKLYE K ++YPR++ Y+ EE G + + Sbjct: 274 PLLHTLDSLTIVANKLYKYTPDQVLASAQKLYEG-KYLSYPRTEDPYITEE---GYYNLQ 329 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSSAI-NLTENEAKVYNLI 406 D L + + DD K+ +H A+IPT ++ + +L E E +V+ LI Sbjct: 330 KFFVGLCRDFLGVTNFSFMGKPKSVDDSKITGSHDALIPTGYTNGLESLAERERRVFELI 389 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGW-----RTLLGSKERDEENDG 461 + L F + + K + D F L AGW + + + + E D Sbjct: 390 LYRCLESFSESSQYEKGIYLFDNQGTPFKTNTNKLLYAGWERYTPKNKTAATDEEGEADD 449 Query: 462 TPLPVV----AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDK--DLKKI 515 + V+ +GD + E V E +++PP +T ATL + + +F+Q++ +L K Sbjct: 450 EKITVLDLPYRQGDAVAIEAKNVREIESRPPAIYTPATLTDDLCNLDKFLQEQSPELHKK 509 Query: 516 LRAT---DGL--GTEATRAGIIELLF-KRGFLT-KKGRYIHSTDAGKALFHSLPEM-ATR 567 L + GL GT+ TR GI++ L KR F+T +K +Y+ T+ G ++++ ++ Sbjct: 510 LSSQFELKGLQIGTKGTRPGILDTLIQKRQFITLQKNKYL-PTELGLQFYNAIKDLEVVN 568 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 TA E L QI+E + + L+ + ++ Sbjct: 569 VAQTARLEYQLKQITEGKLLVTQYYNNLLQYVQNMV 604 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 160 bits (405), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 160/601 (26%), Positives = 265/601 (44%), Gaps = 84/601 (13%) Query: 3 LFIAEKPSLARAIADVL-PKPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPDAYD 55 + I EKP + IA L P +K G +E + +GHL +P + Sbjct: 11 VIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLY-SLRPRQSN 69 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 + DL P + + V LNVI++F A +HA D D EG L+ Sbjct: 70 EEH----FFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGFNA 125 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCV------SALARARAD 169 L Y E ++ R + L + ++RA P+ V S AR D Sbjct: 126 LKY-GCGEEALRKTSRMKFSTLTREEIQRAYKN--------PIEVDYGQVDSGAARHILD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 +++G+N++R+ + A + + LS GRVQTP L ++V R++EI +F ++ ++A + Sbjct: 177 FIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAEL 236 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 E A + + G++ R L + ++ + G A V + Sbjct: 237 ----GEGIIA-----------ESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKP 281 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE----EHFAGR 344 P+PF L LQ EA + FG S + I Q LY T +YPR+ + LPE E Sbjct: 282 PVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLY-TEGYTSYPRTSSQKLPESIGYEKILKN 340 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYN 404 A VH + L P+ + + K+ DAH AI PT + L+++E KVY+ Sbjct: 341 LAKNPRFGVHI-ERLRGPLKPHEGK------KEDDAHPAIHPTGLLPS-ELSKDEKKVYD 392 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGW-RTLLGSKERDEENDGTP 463 LI +++ F DA+ + +EL+I + +F + +++AGW + +K DEE Sbjct: 393 LIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEE----- 447 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 P ++ GD L ER+T+PP + +A+L+ + GLG Sbjct: 448 FPEISGGDSLAVRSVSADERETKPPARYNEASLIREL-----------------ERRGLG 490 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQ 580 T++TRA II L+ R ++ +G+ I + G+ + +L E ++T +E L Sbjct: 491 TKSTRADIIAKLYDRKYI--EGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELED 548 Query: 581 I 581 I Sbjct: 549 I 549 >UniRef50_C2H7T8 DNA topoisomerase n=2 Tax=Enterococcus faecium RepID=C2H7T8_ENTFC Length = 479 Score = 160 bits (404), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 114/342 (33%), Positives = 175/342 (51%), Gaps = 20/342 (5%) Query: 272 QPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRS 331 + A VT+ + + + AP FSLS LQ A KRF SA L I QKLYE K+++YPRS Sbjct: 39 ENAEVTNVKVEEKRQYAPKLFSLSDLQSFANKRFKYSADKTLSIAQKLYE-KKVLSYPRS 97 Query: 332 DCRYLPEEHF------AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAII 385 D Y+ F R+ + + + P L + R D KV H+AII Sbjct: 98 DTNYIGSPEFDYLKSNLSRYLELVGVGISEPQL--------NENKRYVDGSKVQEHYAII 149 Query: 386 PTARSSAI-NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEA 444 PT + ++T++E +Y L+ + L F ++ + I+ I + F +K + E Sbjct: 150 PTKTLPKLSDVTKDEKNIYLLVLYRTLAIFEKPYIYDETTIDTAINQVLFQSKGKTEKER 209 Query: 445 GWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA 504 GW+ L +E+D+ + LP V D + E E +TQPP ++T+ TLL+AM + Sbjct: 210 GWKRLYKQEEKDKYD--PLLPEVTVNDSVAFAL-ETKEGKTQPPNYYTEGTLLTAMKHVG 266 Query: 505 RFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE- 563 R + DK K IL+ T+G+GTEATRA IIE L K+ ++T I+ T+ G+ L + E Sbjct: 267 RAMDDKGSKDILKETEGIGTEATRASIIETLKKQDYITISKSKIYVTEKGELLCRIIAED 326 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 MTA WE L +I +Q + F+ + + LI++ Sbjct: 327 EIANAGMTAQWERYLKKIRSQQGTQEAFLGSIERFVQHLIEK 368 >UniRef50_C0SQM2 Putative DNA topoisomerase n=1 Tax=Lactobacillus brevis RepID=C0SQM2_LACBR Length = 705 Score = 159 bits (403), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 160/615 (26%), Positives = 278/615 (45%), Gaps = 85/615 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRK-GDGFIECG--NGQV-VTWCIGHLLEQAQPDAY-DSR 57 + + EK S A L P +K G ++ N V GHL + P+ Y D+ Sbjct: 4 VVLTEKSSQIDPYAKALGTPKKKQGSVWVHSALLNADVQFVAASGHLFKLDGPEDYNDAW 63 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTK-QLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 R N LP+VP+K++ + + + + N IK+ + A E++ A DPD++G+++ E+L Sbjct: 64 RDRSNYEQLPMVPQKFKARIKDARARASFNRIKQAITAADEVILATDPDQQGEVIGREIL 123 Query: 117 DYLQLAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 Q P ++ QR L+N L + R+ + L ++ L + + R +WL G+N Sbjct: 124 ---QRIPGGMEKCQRRLLNSSLTAKGALRSFENLVPMAKQEHLGAAGFLQNRLNWLIGMN 180 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD-E 234 ++R I + GY ++ G V+TP L LVV D+EI++F +++++ + A+ + Sbjct: 181 LSRVGGIQLKKRGYYFPVAAGTVKTPTLALVVANDQEIKHFKEAPYWQIE--LTDQANQQ 238 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 RF A QPS +DE + L V + ++ + S + + P F+L Sbjct: 239 RFKA--QPSRHFS-IEDEAKQAL-----AQVTDTLT-----IKSVDQVEQHRLPPKLFNL 285 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN----- 349 +ALQ AAK++G S VL+ + LY+ + +YPR++ + + F A N Sbjct: 286 TALQGYAAKKWGYSGTEVLETMEHLYKDLAITSYPRTESTVIEDAEFDYLKANFNDYAAT 345 Query: 350 ---AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNL 405 +++ PD P+ V D H A+IPT + + ++ LTE E + Y Sbjct: 346 LNLKMAMQVPDARPEFV-----------KTTTDGHPALIPTDKVADLSQLTERERRCYGA 394 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 + ++ L+ F D V K V++ + + + A + + GW K + E L Sbjct: 395 VVKRTLLMFAGDCVLDKTVVKGTLGTEQIYEATGQQFKDLGWTEFDVVKTENRE-----L 449 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P +G ++ E +VE +T+ P+ T+ L S L LGT Sbjct: 450 PSYQQGQQVKIETS-LVEGKTKVPQRITEGMLFSK----------------LFPKYNLGT 492 Query: 525 EATRAGII-ELLFKRGFLTKKG--RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 ATRAGI+ EL+ K ++ KG R ++ T G +M A W+ L Sbjct: 493 PATRAGIVSELIEKNHYIEVKGKRRELYPTSEG-------------INMVAFWQGTLLTD 539 Query: 582 SEKQCRYQDFMQPLV 596 + +QD ++ Sbjct: 540 LKLAKSWQDIFDKVI 554 >UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3G6_KORCO Length = 710 Score = 159 bits (401), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 159/625 (25%), Positives = 277/625 (44%), Gaps = 66/625 (10%) Query: 3 LFIAEKPSLARAIADVLP---KPHRKGD----GFIECGNGQVVTWCIGHLLEQAQPDAYD 55 L + EKP++A+ IA +L K R+G F G V GHLLE P Sbjct: 4 LILTEKPNVAKRIASILSEGAKAKREGKVYYYEFDTGGERYYVAPAAGHLLELDYPPG-- 61 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 +W + + PE+ L+ + L ++++ ++ I+ A D D EG + E+ Sbjct: 62 ----KWEYPSI-VPPERLVLKEIKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALEI 116 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + L + +++ R + L + + + L+ P + R D +G N Sbjct: 117 IKALNW---EGKEILRMEFSSLTKEEIRSSFRDLKPFD--YPRAYAGWVRRVIDLEWGAN 171 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 ++R T+ R G+ VLS GRVQ P L ++V+R+ EI FV K ++ V + D+ Sbjct: 172 VSRGLTLSTRRKGWVRVLSSGRVQGPTLSMIVKREREIREFVPKKYYTV----IVKVDKG 227 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 F+ P + E D++ R AE V + + I +D+R+ S P PF + Sbjct: 228 FSLELAPPKGEERIWDQD---YARRAAESVKDTL-----IARVKSDERKL-SPPPPFDGT 278 Query: 296 ALQIEAAKRFGLSAQNVLD----ICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM-NA 350 +LQ+E + GL+ + + D I QKLYE LI+Y ++ + P+ M Sbjct: 279 SLQVEVSAITGLTPRQIADRTSGIAQKLYEAG-LISYIGTESQKYPKSWKKKDFVDMVKL 337 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 I+ ++P V D+R + KK D H I L +VY +IAR+ Sbjct: 338 IASYSPLKEEAEFVLGDMREAAVEGKKDDPAHPTIHVVGVPEERLEGKYREVYEIIARRN 397 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L DA+ ++ +E ++ F A + GW + +E P V Sbjct: 398 LATLAQDALIKRIRVESNVDGFIFRASGLSVLREGWLRVYPYARMEE------FPEVEDS 451 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 +EL + ++ E++TQPP+ ++ +L+ M + GLGT+ TR Sbjct: 452 EELRVVEVKIEEKETQPPKRYSHISLIKEMERL-----------------GLGTKNTRVQ 494 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 II++L RG+L ++G + T G+A+ L T P++TA E + +I + Sbjct: 495 IIDILKSRGYL-EEGSF-KPTRLGEAIVEVLESFVPALTNPELTAKLERGMNEIELGKLD 552 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVR 612 +F++ + L ++D+ KR ++ Sbjct: 553 PSNFLKESLDELSAIMDEFKRNELK 577 >UniRef50_UPI0001C37C64 DNA topoisomerase III n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37C64 Length = 332 Score = 158 bits (400), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 106/340 (31%), Positives = 169/340 (49%), Gaps = 35/340 (10%) Query: 1 MRLFIAEKPSLARAIADVL------PKPHRKGDGFIECG-NGQVVTWC--IGHLLEQAQP 51 M + AEK SLA+ IA L P G+ E NG+ C +GHL + Sbjct: 1 MVVIYAEKSSLAKEIAHALGAGKRIPLKSEPTVGYYEFTFNGEQAVLCHGVGHLAQLVPA 60 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 YD +YA W+L+ P +P+ ++ P+ + L ++K FL +A +++A DPDREG+L+ Sbjct: 61 KLYDEKYAEWDLSVFPCIPDVFRAAPKAATLNCLKLVKSFLDKADWLINATDPDREGELI 120 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVP---------LCVSA 162 V D + + +R I DL + + A L+S ++ + L ++A Sbjct: 121 FTYVCDVCKC----NKPFKRVWIEDLTEKKIRSAFANLKSPTDKLSNTADGNANDLKLAA 176 Query: 163 LARARADWLYGINMTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF 221 AR DWL GIN+T A T G + +L+VGRVQT + +VV R++ I +F F Sbjct: 177 RARDITDWLIGINLTVAATKKYGNSDVMNKLLTVGRVQTATINMVVEREKAILSFTKTPF 236 Query: 222 FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYND 281 +++ A P + +F A + E+G + A +N G+ +V+S Sbjct: 237 WKLTATFTAP-NGKFEASY-----------EQGNFTDKAAAMAALNDCKGKNGVVSSIET 284 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE 321 K ++E+APL ++ + LQI +K+F SA I QKLYE Sbjct: 285 KHKTEAAPLLYNTTQLQIACSKKFSWSADKTQKIMQKLYE 324 >UniRef50_A8A8D9 DNA topoisomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8D9_IGNH4 Length = 657 Score = 157 bits (398), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 165/569 (28%), Positives = 261/569 (45%), Gaps = 83/569 (14%) Query: 3 LFIAEKPSLARAIADVLPKP---HRKGDGFIECGNGQ--VVTWCIGHLLEQAQPDAYDSR 57 L IAEKP A IA+ L KP + G + E NG+ VV GHL A Sbjct: 6 LVIAEKPKAAEKIANALGKPIVKRKYGVPYWELTNGKKIVVVPAAGHLFGLAPLGK---- 61 Query: 58 YARWNLADLPIVPEKW----QLQPRPSVTKQLNVIKRFLHEASEI-VHAGDPDREGQLLV 112 P+ +W +++ S TK+ + L S + V+A D D EG ++ Sbjct: 62 -------GFPVFDYEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIG 114 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRS-NSEFVPLCVSALARARADWL 171 +++ + +R + R + + L P + RA + LR + E + + LAR DW+ Sbjct: 115 YIIIE--RFGDPRRSK--RMVFHALTPDEIRRAWNSLRPLDWEMIN---AGLARHELDWI 167 Query: 172 YGINMTRAYTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 +GIN++RA R A G LS GRVQ+P L VV R+ ++ FV + +F V Sbjct: 168 WGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKG 227 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 + E P+ E +DE A+H ++ G+ V ND+R S P Sbjct: 228 VSLE-------PTLKFET-KDE---------ADHFISNCLGKVVDVIV-NDERLS--PPH 267 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE-HFAGRHAVMN 349 PF+L LQ+EAA+ +G S I ++LY I+YPR++ + P++ +A ++ Sbjct: 268 PFNLPDLQMEAARLYGFSPSKTQSIAEELY-LDAYISYPRTNSQKYPKDLDYAN---ILK 323 Query: 350 AISVHAPDLLP-QPVVDPDIRNRCWDD---KKVDAHHAIIPTARSSAINLTENEAKVYNL 405 I+ P P + + R R + K AH AI PT + NL+ + KVY+L Sbjct: 324 GIA-SVPQYRPLTKALFKETRGRFSPNNGPKDDPAHPAIYPTGKPPK-NLSPDHMKVYDL 381 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 I R+++ ++V+ + +++ F A R + GW TL +E LP Sbjct: 382 IVRRFMATLASESVYEVTKVVIEVNGQTFKAVGRRVKWKGW-TLYYPFSAPQEKS---LP 437 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 KG+ L + ++ T+PP +T A ++ M + G+GTE Sbjct: 438 SFTKGESLQVKCTRRLQ-YTKPPERYTKAKIVKWMERV-----------------GIGTE 479 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAG 554 ATRA I+E LFKRG+L G +++TD G Sbjct: 480 ATRARIVETLFKRGYLKNVGSKVYATDLG 508 >UniRef50_B0UMR5 DNA topoisomerase n=3 Tax=Methylobacterium RepID=B0UMR5_METS4 Length = 809 Score = 154 bits (388), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 162/592 (27%), Positives = 239/592 (40%), Gaps = 73/592 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCI---GHLLEQAQPDAYDSRYA 59 +F EKPS R + P T CI GHLL +P + Sbjct: 1 MFFFEKPSAMRELQRFFRAP---------------TTVCIAAEGHLLAAQEPAEIRPAWK 45 Query: 60 RWNLADLPIVPEKWQL---QPRPSVT--KQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 W DLPI ++ L Q R + ++ I+R L ++ A DP REG ++ E Sbjct: 46 AWRFEDLPIAVDEIPLCCGQSRSGASHAARIAAIRRALDGVERVIIATDPGREGSMIAWE 105 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR----SNSEFVPLCVSALARARADW 170 VL++L R +V R + L+ ++ RA L S AL R DW Sbjct: 106 VLEHLGY----RGRVDRLRLGALDEVSIRRAFAALGRDPDSGERDYAAYQEALCRRYEDW 161 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 G+N TRA ++ R A ++ G VQTP L L+ + I +FV ++FF + + T Sbjct: 162 HLGLNGTRAVSLRLRPAAFREPWRFGGVQTPTLALLADLERRIRDFVPREFFRIALPVAT 221 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG--QPAIVTSYNDKRESESA 288 + T P E R+ R AE + G P V + +R Sbjct: 222 VSGAELTLWHAPKE----------RIFAREEAEAIAAAARGWAGPLAVAERDVRRPP--- 268 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 P FS L AK FG Q + Q LY+ ++YPR++ +LPE AV+ Sbjct: 269 PRLFSKDTLARRCAKSFGFDPQRTASLAQDLYD-RGFLSYPRTESEHLPESQSGDAPAVL 327 Query: 349 NAISVHAPD---LLPQPVVDPDIRN-RCWDDKKVDAHHAIIPTARSSAINLTENEA-KVY 403 A+ PD L+P P R R K HHAI+P + EA +++ Sbjct: 328 AALGASLPDLAGLVPAPGAVVLRRGPRGHYVKDPGEHHAIVPLRKVPRPGEVGPEAWRLW 387 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGSKERDEE- 458 L+A+ +L PD + + + ++A +F + GWR + G++ DEE Sbjct: 388 ELVAKAFLAAHLPDGIDARTTVSAEVATALGPKRFAVTGSVVRAPGWRAVYGAEAEDEEP 447 Query: 459 ------NDGTP----LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 + P LP VA G+ + V T+PPR T L M + V+ Sbjct: 448 VPGKAKREDEPSAGRLPPVAPGEAARAGEARVEGAMTEPPRRITRGELPVVMGRLIDQVE 507 Query: 509 DKDLKKIL------RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG 554 D LK+ L GLGT ATR ++ L K G++ G AG Sbjct: 508 DPALKRALENPANPNEPRGLGTAATRDAVLPKLEKSGYVVLGGALPADARAG 559 >UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiobacillus ferrooxidans ATCC 23270 RepID=B7J7I8_ACIF2 Length = 705 Score = 150 bits (378), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 161/622 (25%), Positives = 274/622 (44%), Gaps = 89/622 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A I +L G+G V +GH+ + P D+ Y R Sbjct: 3 KLLIVESPTKAHHIQAML-------------GSGWSVKATVGHIRDL--PIKGDAAYVR- 46 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 P +++ R S K + ++ +A + A DPDREG+ + V L + Sbjct: 47 ----PPDFKLNYEITERAS--KTVPALRAAARDAESVYIATDPDREGEAIAWHVCQVLGI 100 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 P +R ++ A+ +AI R+ + +PL + AR D + G ++ + Sbjct: 101 KP---GAAKRVTYQEVTEPAIRKAIAAPRTVN--MPLVAAQEARRALDRIVGWEVSGPLS 155 Query: 182 -ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP-ADERFTAI 239 +G A S GRVQTP L LVV R++ I F +F+V AH+ A + A+ Sbjct: 156 NAIGSRA------SAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAV 209 Query: 240 W-QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W ++ E +QD + A+ + + + VT K + PF+ S++Q Sbjct: 210 WVDGTQEGEYFQD-------KAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQ 262 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 ++ A+ ++ Q L+E H ITY R+D L EE G + A+ L Sbjct: 263 MDGARALKAPVDAIMKAAQSLFE-HGHITYHRTDSPNLSEE---GEGLLRAALKKENLPL 318 Query: 359 LPQPVVDPDIRNRCWDDK--KVDAHHAIIPTARSSAINLTEN--EAKVYNLIARQYLMQF 414 + P R W K +AH AI PT R EN E +Y+LI ++ L Sbjct: 319 VETP--------RRWRSKGGAQEAHEAIRPT-RPMVRQAGENDLEQALYDLIRKRALASQ 369 Query: 415 CPDAVFRK--CVIELDIAKGK---FVAKARFLAEAGWRTLLGSKERDEEND----GTPLP 465 PDAV+++ C ++ + +G+ F A L + GW L DEE P+P Sbjct: 370 MPDAVYQQTSCTLDGGMFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVP 429 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 +A GD + +GE + + T+ P +T++TL+ A+ G+G Sbjct: 430 RLAVGDAVRAARGECLSKTTKAPPRYTESTLIKALE-----------------DHGVGRP 472 Query: 526 ATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLPEMA-TRPDMTAHWESVLTQIS 582 +T A I++ LF R ++ +KG+ +++T+ G+ + +L + D T E+ L +I+ Sbjct: 473 STYASILKNLFAREYIRRKGKSPALYATELGEKIVEALSVFDFSNVDYTREVEADLDRIT 532 Query: 583 EKQCRYQDFMQPLVGTLYQLID 604 E Q R +D + + +++D Sbjct: 533 EGQMRPRDLLAKSFADIQRILD 554 >UniRef50_A3DID2 DNA topoisomerase n=1 Tax=Clostridium thermocellum ATCC 27405 RepID=A3DID2_CLOTH Length = 331 Score = 149 bits (377), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 99/311 (31%), Positives = 167/311 (53%), Gaps = 17/311 (5%) Query: 313 LDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP--DLLPQPVVDPDIR- 369 L+I Q LYE KLITYPR+D R + + V+N I + D + + D++ Sbjct: 5 LEIAQWLYE-KKLITYPRTDSRVISTDVLEEVPKVLNGIYKNPEYRDYVLKIKEMGDLKV 63 Query: 370 ----NRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCV 424 R D+ KV H+AIIPT + + + EN VYNLI +++L F P AV+ Sbjct: 64 TKSTKRYVDNSKVTDHYAIIPTYVNAETVRMDENTKNVYNLIVKRFLAIFFPPAVYNTVR 123 Query: 425 IELDIAKGKFVAKARFLAEAGWRTL--LGSKERDEENDGTPLPVVAKGDELLCEKGEVVE 482 +E + FV+ A+ L EAGW+ + + + ++DEE P+ ++ K + + + E+ E Sbjct: 124 VETVVNNEIFVSNAKTLKEAGWKEVYEVSAPKQDEELTEAPIHLLVKNEAVEAKDFELEE 183 Query: 483 RQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF-- 540 ++T+PP +TD +L+ M +F++D++L++ ++ T G+GT ATRAGII+ L G+ Sbjct: 184 KETKPPSRYTDGSLIITMEKAGKFIEDEELREQIK-TCGIGTSATRAGIIKKLSDIGYIK 242 Query: 541 LTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQPLVG 597 + K + + T G+A+ + A P +TA WE L I K+ + F + L Sbjct: 243 INPKTQVVTPTLKGEAIVELVRRTARELLSPSLTASWEKGLAMIENKETTAEIFEEKLCV 302 Query: 598 TLYQLIDQAKR 608 + + I++ KR Sbjct: 303 YINKTINKVKR 313 >UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales RepID=TOP1_THEAC Length = 770 Score = 149 bits (375), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 161/620 (25%), Positives = 274/620 (44%), Gaps = 77/620 (12%) Query: 1 MRLFIAEKPSLARAIADVLP----KPHR-KGDGFIECGNGQVVTWCI---GHLLEQAQPD 52 R+ IAEK R IA L K HR KG ++E T+ I GH++E Sbjct: 4 FRIIIAEKADAGRRIAYFLSGGQVKSHRAKGTSYLEFEYNGSKTYLIPLSGHIVEAD--- 60 Query: 53 AYDSRYARWNLADLP-IVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 ++S Y+ WN DL ++ + + V Q ++ F + EIV A D DREG+L+ Sbjct: 61 -FESGYSDWNKIDLSDLIDARIVKNIKNKVAYQ--TLQAFRGKVEEIVIATDYDREGELI 117 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 E LD ++ E +++++R + L + + L + L +A AR D + Sbjct: 118 GVEALDIIK---EGKEEIRRAKFSALTKNEILDSFKNLIGVN--YSLADAADARESIDLI 172 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 +G +TR +++ G + LS GRVQTP L +VV R+ EI++F + ++ + I Sbjct: 173 WGSVLTRFFSVTTGRLG-KSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTI--SITFD 229 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 D +F A + E +D++ AE + I G+ V+SY K + P P Sbjct: 230 KDGQFKARYP-----ENIKDQD-------TAEKIYEAIKGKNGRVSSYTSKEDHIRRPAP 277 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 FS + EA+ R G+ + I + LY LI+YPR+D P +V+ + Sbjct: 278 FSTTEFLREAS-RIGIMPTKAMSIAENLY-MRGLISYPRTDNTVYPRS--INLKSVLKKL 333 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDK---KVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 A + V + + +R + + H I P S L + +VY+LI R Sbjct: 334 ENTA---YSKYVKEIETFDRILPSRGRIETTDHPPIYPVD-SPKEQLKGDYGRVYDLILR 389 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKA--RFLAEAGWRTLLGSKERDEENDGTPLPV 466 +L D +K V E +I + KA + + GW + G +D LP Sbjct: 390 HFLSTLYRDG--KKTVAEAEIYVNGYTFKAAGQHTTDRGWTEIYGYDPKD-----VYLPE 442 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G++L + +T+PP + ++LL M + LGT++ Sbjct: 443 LTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEEL-----------------NLGTKS 485 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISE 583 TR II L +RGF+ +G + T G A ++ + + P+MTA E + +I + Sbjct: 486 TRHDIIGKLIERGFI--EGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDRIEK 543 Query: 584 KQCRYQDFMQPLVGTLYQLI 603 + D ++ L++++ Sbjct: 544 NEMSKNDVVEESKKMLHEVL 563 >UniRef50_C3ECC9 DNA topoisomerase n=1 Tax=Bacillus thuringiensis serovar pakistani str. T13001 RepID=C3ECC9_BACTU Length = 376 Score = 148 bits (373), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 90/346 (26%), Positives = 174/346 (50%), Gaps = 23/346 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKG------DGFIECGNGQVVTWCIGHLLEQAQPDAY 54 M++ + EKP ++ ++ R+ D I V+ +GH++E PD Y Sbjct: 1 MKVILCEKPQQMKSYSEAFQSAKRESTHITVKDKEIFGDEEVVMISALGHVVELCNPDEY 60 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + W++ LPI+PE+++++ K++L +A EI+ A DP R G+ + Sbjct: 61 KEEWKNWSMDQLPIIPEEFKMKVSKDKKSIFQNAKQWLQKADEIIIATDPARAGEAIAKN 120 Query: 115 VLDY--LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 ++ + P+K R + + AV + LR E + AR+ +DW+ Sbjct: 121 IIIMAGVNDTPQK-----RLWVKSMTQDAVRKGFQNLRDAEETYSYYLEEQARSVSDWII 175 Query: 173 GINMTRAYTILGRN-AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N +R +T+L R+ G + V S GRVQ+ +L L+ +R++E+E+F + F+E+ H T Sbjct: 176 GMNASRVFTLLFRDKKGVKEVFSAGRVQSALLHLIRQREKELEHFKVQSFYEIHGHFNTN 235 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 + Q + + EE + + L EH A + +++S+ AP Sbjct: 236 GIPYAGKLLQDHNIMKLHSKEEAQGKLQQLQEHT--------ARIQKVTVEQKSKQAPKL 287 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 ++LS+LQ + K++ +S + VL+ Q LY+ ++++YPR++ +++P Sbjct: 288 YNLSSLQAKLNKKYKMSPKVVLETAQSLYDK-RMLSYPRTEYQHIP 332 >UniRef50_Q8TUZ7 Topoisomerase IA n=1 Tax=Methanopyrus kandleri RepID=Q8TUZ7_METKA Length = 587 Score = 147 bits (372), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 181/600 (30%), Positives = 269/600 (44%), Gaps = 75/600 (12%) Query: 3 LFIAEKPSLARAIADVLPKP--HRKGDGFIEC-GNGQVVTWCIGHLLEQAQPDAYDSRYA 59 + IAEKPSLA IA L RK GF G +T GH+LE D R+ Sbjct: 10 VIIAEKPSLAGTIAGFLRGSWDGRKLLGFGRYRGRRFAITSLSGHVLEWWPKDDPGFRHP 69 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE-----ASEIVHAGDPDREGQLLVDE 114 D P ++L+P + L ++R + A ++ A D D EG+L+ E Sbjct: 70 -----DYFPDPGDFELRPIDGKERFLRAVERVVKRYAGCRADRVIVATDNDAEGELIGWE 124 Query: 115 VLDYL--QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVP-LCVSALARARADWL 171 VL +L Q + + +R + + V RA++ P L SALAR ADWL Sbjct: 125 VLVWLKRQGGLDDPECARRMRFSAYTREDVLRALEGALRGERIDPSLAYSALARTIADWL 184 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 YGI +TR ++ + ++SVGRVQTP L LVV R+ E K + TP Sbjct: 185 YGIPLTRRLSLCNDD-----IVSVGRVQTPTLKLVVERERERRKAQKKRRYYWILQAETP 239 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 E T E ++D GR R LA + + V +R S P P Sbjct: 240 IGELRTE--------EKFKD--GRR-ARELASEI------ESIRVVEVRRERRSVRPPTP 282 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F+L+ LQ A K +S + LD+ Q+LYE +ITYPR+ P F + Sbjct: 283 FNLTTLQRAAGKILRISPKRTLDLAQRLYE-EGMITYPRTATNRYPS-TFDHEELLRKLR 340 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSSAINLTENEAKVYNLIARQY 410 + H PD L + R+ K+ D AH I PT R I + ++Y+LI R+Y Sbjct: 341 NAH-PDAL-RDFQRTGRRSEPVSGKEYDGAHPPITPTGRRKYIR-GKLAWRLYDLIVRRY 397 Query: 411 LMQFCPDAVFRK--CVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 L DA+ K V E +FV + + GW ++ ++ E + +P V+ Sbjct: 398 LATLSEDALVVKWRIVAEHPGTGTRFVMEGTEVERDGWYSVYPWEKPRE----STMPDVS 453 Query: 469 KGDELLCEKGEVVERQTQP-PRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +GDEL R+ +P PR ++ + L++ M KK+ GLGTE+T Sbjct: 454 EGDELPANVN--ASRRRKPLPRRYSQSRLVAKM------------KKL-----GLGTEST 494 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWESVLTQISE 583 RA I++ LF RG++ + G + T G+ L L PE+ + ++T E + +ISE Sbjct: 495 RAEIVKKLFDRGYVKRAGSGVAPTKRGERLVELLEDRVPELVS-VELTRRIEREMEEISE 553 >UniRef50_C8WG68 DNA topoisomerase type IA central domain protein n=9 Tax=Coriobacteriaceae RepID=C8WG68_EGGLE Length = 849 Score = 147 bits (371), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 141/513 (27%), Positives = 225/513 (43%), Gaps = 54/513 (10%) Query: 79 PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLN 138 P + + +K +A ++ A D DREG+L+ + L +Q V R + Sbjct: 126 PKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEV-NPTAPVSRARYSAFT 184 Query: 139 PQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRV 198 + + A D L V L + +R D ++G +TR Y L + AGY V S GRV Sbjct: 185 KEEITHAFDNLVELD--VNLASAGASRQDIDLIWGAVLTR-YLTLVKFAGYGNVRSSGRV 241 Query: 199 QTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLH 258 QTP L LVV R+ E FV +D++ ++ D F A P+ R Sbjct: 242 QTPTLALVVARERERLAFVPEDYWVIRGAFGADPDS-FEA---------PHAT--ARFKA 289 Query: 259 RPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQ 317 A+ V+ + G A V S K+ + P PF+ ++L + AA GLS + I + Sbjct: 290 EAEAQAVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSL-MAAASAEGLSPARTMRIAE 348 Query: 318 KLYETHKLITYPRSDCRYLPEE-HFAGRHAVMNAISVHAP---DLLPQPVVDPDIRNRCW 373 LY I+YPR D P A ++ +AP +LL + + R + Sbjct: 349 SLY-MDGYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTA-TRGK-- 404 Query: 374 DDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK 433 K+ H I PTA+++ +L + K+YNLIAR++L AV + LD+ Sbjct: 405 --KETTDHPPIYPTAKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEP 462 Query: 434 FVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTD 493 FVAK L + G+R + + +E LP +++G+ + ++QT+PP ++ Sbjct: 463 FVAKGDVLVKPGYRAIYPYGLKKDEQ----LPALSEGETVAFNGAVCTKKQTEPPARYSQ 518 Query: 494 ATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDA 553 L+ M + GLGT++TR IIE L+ + I + Sbjct: 519 GKLIQEMEKL-----------------GLGTKSTRHAIIERLYAVKYCMNDP--IEPSQL 559 Query: 554 GKALFHSLPEMA---TRPDMTAHWESVLTQISE 583 G A+ +L + A T P+MTA E + I+E Sbjct: 560 GMAVCDALDKFAPHITHPEMTAELEEEMDNIAE 592 >UniRef50_C9RG81 DNA topoisomerase I n=2 Tax=Methanocaldococcus RepID=C9RG81_METVM Length = 928 Score = 145 bits (366), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 140/507 (27%), Positives = 237/507 (46%), Gaps = 42/507 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKG-DG--FIEC---GNGQVVTWCIGHLLEQAQPDAYDS 56 L I EKPS+A+ IA+ L KP +K DG + E G +V +GHL + + ++ Sbjct: 4 LIICEKPSVAKKIANALGKPKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVENE--NN 61 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + ++ + D+ VP + + V K + +K+ EA E A D D EG+L+ L Sbjct: 62 EFGKYPIFDIKWVPASVD-KGKEYVNKYIKALKKLSKEADEFYIATDWDIEGELIGYHAL 120 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y R++ +R + L + + +A + + L + +R DW +GIN+ Sbjct: 121 KYCC----GREKAKRMRFSSLTKKEIVKAFEN--PDEIDYGLVDAGESRHILDWYFGINL 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RA R +SVGRVQ P L + R+ EI+ F+ K ++ ++A + + Sbjct: 175 SRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALL----KDNL 230 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSL 294 AI + E + DE+ A+ V +I + + +V KR + P PF L Sbjct: 231 KAIHEK----EKFWDEKE-------AKSVYEKIKDEKSAKVVEIKKTKRRIKPLP-PFDL 278 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 LQ EA F +S + +I Q+LYE LI+YPRS + LP++ ++N I H Sbjct: 279 GTLQREAYSYFKISPKETQEIAQRLYE-RALISYPRSSSQKLPKDR-KYLEDILNIIKNH 336 Query: 355 -APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 + +++ +++ + KK D H I L+E E K+Y+LIAR+ L Sbjct: 337 PIYGKWAEKILEKNLKP--VEGKKDDPAHPAIHIVDIPKEELSEKEKKIYDLIARRTLSA 394 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F +A +++DI KF + GW + + DE LP + K D + Sbjct: 395 FWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDE----IELPPLKKNDII 450 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAM 500 EK + ++TQPP+ +T A+++ + Sbjct: 451 KVEKITITRKETQPPKRYTVASIIKEL 477 >UniRef50_A2BLA3 DNA topoisomerase n=1 Tax=Hyperthermus butylicus DSM 5456 RepID=A2BLA3_HYPBU Length = 682 Score = 145 bits (366), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 167/603 (27%), Positives = 257/603 (42%), Gaps = 82/603 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCI-------------GHLLEQA 49 L IAEKP AR IA+ L D I C G + W + GHL Sbjct: 15 LVIAEKPKAARKIAEAL------SDKPIACKLGGIPYWIVTWMGTRYVIVPAAGHLFGLT 68 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQ-LNVIKRFLHEASEIVHAGDPDREG 108 D + + A L W + + T++ L IK+ A V+A D D EG Sbjct: 69 T-DKHGFPVFEYYWAPL------WAVDSSSAHTRRFLEAIKKLARHAVRFVNACDYDIEG 121 Query: 109 QLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRL-RSNSEFVPLCVSALARAR 167 ++ +L L EKR R + L Q V RA RL R + + + + LAR Sbjct: 122 SVIGYNILR--ALGVEKR--ALRAKFSALTRQDVRRAFSRLERLDWDMIN---AGLARHE 174 Query: 168 ADWLYGINMTRAYTILGRN-AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 DWL+GIN++RA R+ G VLS GRVQ+P L V R + FV +F V A Sbjct: 175 LDWLWGINISRALMESLRSVTGRSKVLSAGRVQSPTLVEAVSRTIKRNLFVPLPYFTVTA 234 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 + R + A + E R+ + A + +V Y++ E Sbjct: 235 TVELGGKARRLQV-----ASFELRSEAQRVARQLRATGYL--------VVREYSEYVERI 281 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P PF+L LQ+EA++ G S + ++LY LI+YPR++ + +P A Sbjct: 282 PPPYPFNLGDLQVEASRILGFSPYYTQKLAEELY-LEGLISYPRTNSQKIPPT--IDISA 338 Query: 347 VMNAI--SVHAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSSAINLTENEAKVY 403 ++ A+ +L+ + R + K D AH AI PT L++N ++Y Sbjct: 339 IVQALVRQTRYRELVEYLLRATRGVLRVNNGPKEDPAHPAIHPTGEPPHSGLSKNHLRLY 398 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDI-AKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 +LI R++L P AV + + L G + GW + + EE Sbjct: 399 DLIVRRFLASMAPPAVLVRARLILSAEGLGSASITGVRIVSPGWMQIYYWAKPSEEY--- 455 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 +P + +G + + V TQPP T +L+ M + G+ Sbjct: 456 -IPRLYRGQRIQVKSVSVQTSYTQPPELHTKTSLVKWME-----------------SKGI 497 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWESVL 578 GTEATRA I+ELLF+RG+L +G + +T+ G + + L P++ T ++T +E +L Sbjct: 498 GTEATRARIVELLFERGYLRSEGGRVQATELGLTVANILQTYFPDI-TSVELTRRFEELL 556 Query: 579 TQI 581 I Sbjct: 557 EAI 559 >UniRef50_C3NE35 DNA topoisomerase n=9 Tax=Sulfolobus RepID=C3NE35_SULIY Length = 677 Score = 144 bits (363), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 172/634 (27%), Positives = 268/634 (42%), Gaps = 93/634 (14%) Query: 3 LFIAEKPSLARAIADVLP-KPHRKGDGFIECGNGQVVTWCI--------------GHLLE 47 L IAEK A+ IA+ L KP I C V W I GHL Sbjct: 11 LIIAEKSKAAKKIAEALSEKP-------ILCRKYNVNYWIIKDHDNNKYVIVPAAGHLFG 63 Query: 48 QAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQL-NVIKRFLHEASEIVHAGDPDR 106 + W P+ W++ TK+ +I A ++A D D Sbjct: 64 LQGKSGFPVYDVDWK----PL----WEIDKNSYYTKRYYQLISSLSKYALGFINACDYDI 115 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG ++ ++ YL ++ +R + L + A R S ++ + + +AR Sbjct: 116 EGSVIGYLIIKYLG----DTKKAKRMKFSALTKSDILLAF-RNVSTLDY-DMINAGVARH 169 Query: 167 RADWLYGINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK 225 + DWL+GIN++RA I L A + +LS GRVQ+P L VV + E F+ F V Sbjct: 170 KIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVS 229 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 IV D ++ + ++ E + A +NR+ + VT +K Sbjct: 230 V-IVKIKD--YSLNIKINKEFEKLAE----------ANEFLNRLINKTVKVTQVENKIRI 276 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 P PF+L+ LQ+EA + +G+S NV I + LY LI+YPR++ + +P + Sbjct: 277 LERPPPFNLTDLQVEAGRIYGISPYNVERIAEDLY-LDGLISYPRTNSQKIPST--INIY 333 Query: 346 AVMNAISVHAPDLLPQPVVDPD-----IRNRCWDDKKVDAHHAIIPTARSSAINLTENEA 400 ++ + + L V +R DD AH AI PT S NL N+ Sbjct: 334 NIIKGLENSSYRKLVNLVRKITGGKYIVRQGVKDDP---AHPAIHPTGESPK-NLPNNKF 389 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKG--KFVAKARFLAEAGWRTLLGSKERDEE 458 K+Y+LIAR++L DA + L +A +F + E W + E+ Sbjct: 390 KIYDLIARRFLASVSADAKLSNTIYTLKVADFPLEFSVSYTKIPERNWLDIYHFHNVRED 449 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 N P+ +++KGDE + G+V ++P +T +LL M Sbjct: 450 N---PI-LLSKGDEGIISDGKVNISLSKPTSRYTKVSLLKWM-----------------E 488 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPD-----MTAH 573 + LGTEATR IIE+L KR +LT GRYI T G + L + PD MTA Sbjct: 489 SSDLGTEATRGRIIEILVKRRYLTSNGRYIVPTKLGFYIAELLNKFF--PDIVDVRMTAD 546 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 E+ L I + + ++ + L + I++ K Sbjct: 547 MENKLEMIKTGKILESEVIKENIEKLNKFIEEYK 580 >UniRef50_D2EGP7 DNA topoisomerase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EGP7_9EURY Length = 703 Score = 142 bits (359), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 160/666 (24%), Positives = 292/666 (43%), Gaps = 82/666 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIEC--------GNGQVVTWCIGHLLEQAQPD 52 M+L IAEK + A IA L + + F G VV GH+ P+ Sbjct: 22 MQLIIAEKSTAAETIAKNLAETKIRIQDFGPVKVWYTQINGEETVVMPLKGHIKNVRYPE 81 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 + +WN L + + +L P+ + VIK+F +A +++ A D D EG+ + Sbjct: 82 TF----RKWNEETLMKMIDA-KLVYYPTAEDNIAVIKKFAKKADKVIIATDYDTEGESIG 136 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 E +D ++ + +V R + + L + + A L+ ++ L SA AR D + Sbjct: 137 FEAIDVVR-EENTKSKVYRSVFSSLTTKELSEAFKNLQKPNK--DLSDSADARREIDLIL 193 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G +TR ++ G LS+GRVQTP L ++V RD E F + ++ Sbjct: 194 GAVLTRFISLAAERLG-NSFLSIGRVQTPTLAIIVARDSERRAFKPEKYW---------- 242 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 RFTA Q +A + ++G++ AE + + + A++ + K+ P PF Sbjct: 243 --RFTATIQTKDAEFLAEYKDGKVFDEKTAEKLRKTKNEKKAVIDKVDMKKRRMPPPKPF 300 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE----EHFAGRHAVM 348 + +A + +A G S N + I Q LY ++YPR+D P + Sbjct: 301 NTTAF-LRSAAAIGFSVPNAMRIVQGLY-MKGYVSYPRTDSEAYPPTLDLKEILNELRNS 358 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 ++ S ++L +P+ +P D + H +P + L EA++++LI+R Sbjct: 359 SSYSKAVSEILKKPL-NPTKGKEAKDHPPI--HPVKLPNEK-----LNPQEARIFDLISR 410 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 ++L ++ I+LDI +F AK + GWR++ + +E LP + Sbjct: 411 RFLATLSDESEEEIISIKLDIKGNEFTAKGSRILVPGWRSVYIFSKYEE----NILPEIK 466 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L K + +E T PP +++ +L M +DL LGT+ATR Sbjct: 467 EGEILKVLKIDEIEDFTTPPGNYSQGAILKIM---------EDL--------NLGTKATR 509 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 I++ L +R +++ R + ++ A+ ++ +++ T ++TA E + + E Q Sbjct: 510 PEILKKLMERRYIS-ASRTLIPSEVAFAVIENMQKVSNEITGAELTATLEKEMKLVEEGQ 568 Query: 586 CRYQDFMQPLVGTLYQLID--QAKRTPVR---------QFRGIVAPGSGGSADKKKAAPR 634 + + + L +++ Q+KR ++ Q+ P SGG K K Sbjct: 569 KKKAEVVNESRDMLRKVLKNLQSKRKEIKELMHKALLQQYIFGTCPKSGG---KLKLVVS 625 Query: 635 KRSAKK 640 K+S K+ Sbjct: 626 KKSHKR 631 >UniRef50_UPI0001B43857 protein TrsI n=1 Tax=Listeria monocytogenes FSL F2-515 RepID=UPI0001B43857 Length = 345 Score = 142 bits (357), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 104/340 (30%), Positives = 166/340 (48%), Gaps = 16/340 (4%) Query: 268 RISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLIT 327 RI A V + +K E ++PL FSLS LQI K+F S + L QKLYE K ++ Sbjct: 12 RIGPTEATVLNMVEKEEKHASPLLFSLSNLQILMNKKFKYSPKETLQGVQKLYEK-KWLS 70 Query: 328 YPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 YPR+DC ++ ++ F+ + A + P ++PD R D+ +V HHAIIPT Sbjct: 71 YPRTDCTFITQKEFSYLKMKLQEYKAFAHIEVYTPNLEPDF--RYVDNHEVHEHHAIIPT 128 Query: 388 ----ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAE 443 + LT E ++Y + + F P + ++ ++L I + F AK R + Sbjct: 129 RIIPSAEEFSKLTTLEKQIYTWVLHVTIAMFAPPMLIKEIAMDLRIGELLFEAKERTPVD 188 Query: 444 AGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGI 503 GWR ++ + E+ L GD + G +ER +PP FT+ L+ AM Sbjct: 189 MGWRKIILGNNQKEKISRQSLSNFHIGDTIHGFLGG-LERDKKPPSPFTEGALIHAMKNA 247 Query: 504 ARFV-QDKDLK-KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 + Q K++ K++ G+GTEATRA ++E L + +L ++ TD GK L + Sbjct: 248 GKKAGQSKEMGLKVM----GIGTEATRADVLEKLKNQDYLKLTKNKLYVTDKGKELGRVI 303 Query: 562 PE--MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTL 599 + + DMTA E+ L I E ++F++ L G + Sbjct: 304 ENDPLLSNIDMTASLETALHSIGEGITTQEEFLKNLKGMI 343 >UniRef50_Q64CK3 DNA topoisomerase n=2 Tax=environmental samples RepID=Q64CK3_9ARCH Length = 681 Score = 141 bits (356), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 159/599 (26%), Positives = 263/599 (43%), Gaps = 70/599 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECG----NGQVVTWCIGHLLEQAQPDAYD- 55 M I EK + A+ IA +L K + +VV GH+ PD+Y+ Sbjct: 1 MHYIITEKGTTAKKIAAILSNGKAKKKKIGGIDAHEFDEKVVIGLSGHVFRLDFPDSYNN 60 Query: 56 -SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 S+ + L D IV + + + K L I + +A I A D DREG+L+ E Sbjct: 61 WSKVDPYKLIDAKIV----TVALKKDIVKTLGQIAK---KADYITVATDYDREGELIGVE 113 Query: 115 VLDYLQ-LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEF-VPLCVSALARARADWLY 172 L+ ++ + PE +V R + + + ++ D + SE L SA R D ++ Sbjct: 114 ALNSIKKINPE--LKVDRMRYSAITEKDIK---DSFAARSEVDYNLAASAEVRQIIDLVW 168 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G ++TR ++ G G SVGRVQ+P L L+V +++EI FV + ++E+ A + T Sbjct: 169 GASLTRFVSLSANRLG-DGFFSVGRVQSPTLALLVEKEKEIAKFVPRKYWELHAKLKTEN 227 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESESAPLP 291 E F + ++ E +DE AE RI + + V + K E P P Sbjct: 228 GEIFDVTHKTAKFWE--KDE---------AEVAKARIEAAKEGFVRTLKTKLRVEKPPTP 276 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE----EHFAGRHAV 347 F + I AA + + ++ I + LY LI+Y R+D P+ + Sbjct: 277 FDTTTF-IRAASAISYTPKRLMAIAEGLY-LGGLISYHRTDNTTYPDTLDLKALVQMFQK 334 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 HA LL + + P KK H I P A ++ L ++E KVY L+ Sbjct: 335 HKEFGKHAKLLLTKKELKPTAGK-----KKTTDHPPIHPVAETTKDKLEKDEWKVYELVV 389 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 R++L A + + +I AK R L E G+ + ++++E +P + Sbjct: 390 RRFLATLSDAAKWEDTNVTAEIGDEPLTAKGRLLKEQGFLAIYPYQKKEE----LVIPQL 445 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + +++ E E+VE++T+PP + A L+ M + GLGT++T Sbjct: 446 KEDEKVDLEHIELVEKETKPPNRISQAGLIKKMDDL-----------------GLGTKST 488 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISE 583 R II L+ R ++ +G T+ AL SL + A T+ +MT E + +ISE Sbjct: 489 RHEIIGKLYDRTYV--QGNPAKPTEKAVALIDSLEKYAALITKSEMTKTLELEMNEISE 545 >UniRef50_Q5V1P3 DNA topoisomerase I n=1 Tax=Haloarcula marismortui RepID=Q5V1P3_HALMA Length = 1364 Score = 141 bits (355), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 144/540 (26%), Positives = 234/540 (43%), Gaps = 52/540 (9%) Query: 1 MRLFIAEKPSLARAIADVLPK-----PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 MRL I EK + AR IA++L + R G GN +VV GH++ P+ Y+ Sbjct: 1 MRLIITEKDNAARRIAEILSEGGASANRRNGVNVYRWGNTRVVGLS-GHVVGVDFPEEYN 59 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W + P+ + P+ + +K+ EA E A D DREG+L+ E Sbjct: 60 D----WRDVE-PVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEA 114 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA--DWLYG 173 Y + E V R + + + V A +N + + ++A AR D ++G Sbjct: 115 --YELIREETDAPVDRVRFSSITEREVRDAF----ANPDDIDFDLAAAGEARQIIDLVWG 168 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 +TR ++ R G +SVGRVQ+P L L+V R+ EI+ F +D++E+ A + Sbjct: 169 AALTRFLSLSARQLG-DDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQKNG- 226 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNR-----ISGQPAIVTSYNDKRESESA 288 F A + + D++G+ R E + + A VTS + ++S Sbjct: 227 SGFEAQY--------FYDDDGKEAERVWVEDDADDAYADLTNVDAATVTSVRRRTRTDSP 278 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP----EEHFAGR 344 P PF+ +A I AA G SAQ + I ++LY T ITYPR+D P E+ Sbjct: 279 PTPFNTTAF-ISAASSLGYSAQQAMSIAEELY-TTGYITYPRTDNTVYPDDLEEDALLDE 336 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVY 403 A LL Q DI D++ D H I PT +L+++E ++Y Sbjct: 337 FVGAGHFGEDAEALLEQ----DDITATEGDEETTD-HPPIHPTGEIPPKADLSDDEWEIY 391 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 L+ R++ A + + D A + L E G+ + E + Sbjct: 392 ELVVRRFFATVAEAATWEHLRVVADAGGRSLKANGKRLVEPGYHEVYPYSSASENH---- 447 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM--TGIARFVQDKDLKKILRATDG 521 +P V +G+EL + + +QTQPPR + + L+ M G+ D ++R+ +G Sbjct: 448 VPDVEEGEELAISEVRMEAKQTQPPRRYGQSRLIQTMEDKGLGTKCLTADSDVLVRSENG 507 >UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q46AN3_METBF Length = 855 Score = 140 bits (353), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 165/654 (25%), Positives = 282/654 (43%), Gaps = 84/654 (12%) Query: 5 IAEKPSLARAIADVLPKPHRKGDGFIE--------------CGNGQVVTWCIGHLLEQAQ 50 AEK A IA +L G+G +E G +V GH++ Sbjct: 6 FAEKNKAASQIASIL------GEGEVERITVEGLPVYEFKWKGEEWLVMGLSGHIMNYDF 59 Query: 51 PDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQ--LNVIKRFLHEASEIVHAGDPDREG 108 P+ Y+ +W + ++ E + P+ VT+ +K A++IV A D DREG Sbjct: 60 PEQYN----KWKEVNPGVLLE---IDPQKLVTRTDYAAAVKNLAKRANKIVLACDYDREG 112 Query: 109 QLLVDEVLDYLQLAPEKRQQV--QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 + + E + EK V +R + L+P+ V++A + L N ++ + ++A AR Sbjct: 113 ENIGFEA----KTLAEKVTNVPIERARFSSLSPKEVKKAFESL-INPDY-NMAMAAEARQ 166 Query: 167 RADWLYGINMTRAYTILGRN-AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK 225 D G TR T+ R A + +LS+G QTP G V R++ I F AKDF+++ Sbjct: 167 ILDLKMGAAFTRFVTLSVRERARTKDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKIT 226 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRL--LHRP-------LAEHVVNRISG-QPAI 275 A I + + E + + E G HR A + R+ G + + Sbjct: 227 A-IFSAESGKEGGKEGRKEGRKEGKKERGDFEGTHRAGNIHDKEKAAEIFKRLKGTKEGL 285 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V K S P P + + A+K G+S + L++ ++LY +YPR++ Sbjct: 286 VAKKTVKETKTSPPNPLNTTEFLKRASKFLGISPELALEVAEQLY-LAGFTSYPRTETNK 344 Query: 336 LPEEHFAGRHAVMN-----AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS 390 E+ F + V + A +L P+V + D + A S Sbjct: 345 YAED-FDFKSLVFDFARQKEYKPFAESILIAPIVPKNGEKDAHDHPPIHPIRAASRGEVS 403 Query: 391 SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL 450 SA+N+ + +VYNLIAR +L P AVF K + L + + F + L ++GW L Sbjct: 404 SAVNIPQ-APEVYNLIARHFLANLMPAAVFEKTHLHLLVNEEPFDSSGTVLKDSGW---L 459 Query: 451 GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDK 510 + + + D LP V +G ++ +K + +T PP+ T+A LL+ M DK Sbjct: 460 EAYPFENKKDKL-LPFVEEGQKVGVKKLSNTKSKTSPPKKLTEAELLTLM--------DK 510 Query: 511 DLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATR 567 +G+GT+AT IE KRG+L KG+ I D G L L + + Sbjct: 511 ---------NGIGTKATAPTHIETNKKRGYLETKGKTISILDTGFTLMDGLSLTVPILVK 561 Query: 568 PDMTAHWESVLTQISEKQCRYQDFM---QPLVGTLYQLIDQAKRTPVRQFRGIV 618 P++ A E+++ ++ + + ++ + L+ +Y ++ K+ G + Sbjct: 562 PEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQLEANKKELTSSIAGTI 615 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 140 bits (353), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 148/557 (26%), Positives = 249/557 (44%), Gaps = 73/557 (13%) Query: 83 KQLNVIKRFLHEASEIVHAGDPDREGQLL---VDEVLDYLQLAPEKRQQVQRCLINDLNP 139 K + I + A I A DPDREG+ + + E+L L +K +QR + ++ P Sbjct: 62 KHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKERGLLKDK--PMQRIVFTEITP 119 Query: 140 QAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQ 199 +A++ AI + R + L + AR D+L G N++ +L R Q LS GRVQ Sbjct: 120 RAIKEAIQKPRMIAS--DLVDAQQARRALDYLVGFNLS---PVLWRKV--QRGLSAGRVQ 172 Query: 200 TPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHR 259 +P L ++V R+EEIE F+ ++++ + A PA + F+A + + E+ + Sbjct: 173 SPALRMIVEREEEIEAFITREYWSIHAECTHPA-QHFSAKLI---KLDGKKFEQFTITDS 228 Query: 260 PLAEHVVNRI----SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDI 315 A RI G+ I N +R+ AP PF S LQ EA+++ G + + + I Sbjct: 229 DTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAP-PFITSTLQQEASRKLGFTTRKTMQI 287 Query: 316 CQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPD 367 QKLYE + LITY R+D L + + ++ + + LP P+ Sbjct: 288 AQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDII--ARDYGTNALPD---KPN 342 Query: 368 IRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQYLMQFCPDAVFRK 422 + + + +AH A+ PT+ A L+ E ++Y L+ ++ + A+ Sbjct: 343 VYTTKSKNAQ-EAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRTVASQMIPAILNT 401 Query: 423 CVIELDI-------AKGKFVAKARFLA--EAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 ++L A G V FLA E G +K +++++G LPV+ G+ + Sbjct: 402 TSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGK----DNKNAEDDDEGRKLPVMKTGENV 457 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 E+ + TQPP +T+A L+ A+ G+G +T A II+ Sbjct: 458 PLERILTEQHFTQPPPRYTEAALVKALEEY-----------------GIGRPSTYASIIQ 500 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQD 590 L R ++ +GR TD G+A+ L T+ D TAH E L IS + + Sbjct: 501 TLLFRKYVDMEGRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELDAISRGEEEWIP 560 Query: 591 FMQPLVGTLYQLIDQAK 607 M+ +L++ K Sbjct: 561 LMKKFWVPFKELVEDKK 577 >UniRef50_A3DP02 DNA topoisomerase n=9 Tax=Desulfurococcaceae RepID=A3DP02_STAMF Length = 723 Score = 140 bits (353), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 168/627 (26%), Positives = 274/627 (43%), Gaps = 83/627 (13%) Query: 3 LFIAEKPSLARAIADVLPK-PHRK---GDGFIECGNGQ---VVTWCIGHLLEQAQPDAYD 55 + IAEKP A IA L + P RK G + N +V GHL D Y Sbjct: 56 VVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLY-GLHTDQYG 114 Query: 56 SRYARWNLADLPIVPEKW----QLQPRPSVT-KQLNVIKRFLHEASEIVHAGDPDREGQL 110 P+ +W Q+ P+ T K + V+ + A V+A D D EG + Sbjct: 115 ----------YPVFKYEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYDIEGSV 164 Query: 111 LVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRS-NSEFVPLCVSALARARAD 169 + ++ Y EK R + L + + + +L S + E + + L R D Sbjct: 165 -IGYLIIYFHGDLEKSL---RAKFSSLTIEELRESFRKLTSLDWEMIE---AGLCRHELD 217 Query: 170 WLYGINMTRA-YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 W++GIN++RA + + +G + +LS GRVQTP L VV +D E F+ + + +I Sbjct: 218 WIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINI 277 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLLH-RPLAEHVVNRISGQPA-IVTSYNDKRESE 286 E + + +G+ + + A+ +++ I IV Y +K + Sbjct: 278 F-------------KNNYEIHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTL 324 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 + P F+L LQ EAA+ +G S I +KLY LI+YPR++ + LP A Sbjct: 325 NPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLY-LDALISYPRTNSQKLPPT--LNYKA 381 Query: 347 VMNAIS--VHAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSSAINLTENEAKVY 403 +MN +S + +L+ +V+ + K D AH AI PT +L ++E K+Y Sbjct: 382 IMNKLSRINNYKELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKPK-DLGKDEWKIY 440 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGK---FVAKARFLAEAGWRTLLGSKERDEEND 460 +LI R++L F A ++ L+ K F A + + + GW + +E Sbjct: 441 DLIVRRFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSKPEERF- 499 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP G+++ K + + T+PP +L M + Sbjct: 500 ---LPKFQYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENV----------------- 539 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWES 576 G+GTEATRA IIE+LF R +L G + +TD G + L PE+ T +T H+E Sbjct: 540 GIGTEATRARIIEILFSRYYLRSVGGRVEATDLGLGIIEVLMEYFPEI-TSVSLTRHFEE 598 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLI 603 + +I R ++ ++ TL +LI Sbjct: 599 EMEKIRLGVKRREEVVKDAKNTLIKLI 625 >UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02GM2_PSEAB Length = 641 Score = 139 bits (349), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 152/549 (27%), Positives = 240/549 (43%), Gaps = 78/549 (14%) Query: 83 KQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKR----QQVQRCLINDLN 138 K + +K +A EI A DPDREG+ + +L + KR + + C+ +L+ Sbjct: 70 KTVARLKELRQKAVEIYVASDPDREGESIGWHILQAAGIKNYKRVAFKEITKSCITAELS 129 Query: 139 PQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT-RAYTILGRNAGYQGVLSVGR 197 R +D +P S R D L G +T ++GR + GR Sbjct: 130 S---PRRLD--------LPKVASQECRRVIDRLVGYLVTPELRRVMGRPT------TAGR 172 Query: 198 VQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER-FTAIWQPSEACEPYQDEEGRL 256 VQ+ + LVV R+ EI F A F V+ V+P+D R +TA W P + EE Sbjct: 173 VQSVAVYLVVLREREIRAFTAIKHFGVELTFVSPSDGRTWTAEWDPVPV---FASEEFPY 229 Query: 257 LH-RPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDI 315 + R LAE +V I IV + D E+++ P PF S+LQ+ A S + + Sbjct: 230 VQDRQLAE-LVGAIRN--VIVETCIDSEETDAPPAPFISSSLQMAAGNALKWSPDKTMKV 286 Query: 316 CQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDD 375 Q+LYE LITY R+D + ++ AV A+ + + D D + Sbjct: 287 AQRLYE-QGLITYHRTDNPNISKDSMPDIRAVAKALGLKCVEQQRMFKADQDAQ------ 339 Query: 376 KKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DI 429 + H AI PT ++A T +E +Y LI + L AV+ I L D Sbjct: 340 ---EGHPAITPTDWMAAAAGETADEQALYQLIRVRALASQIEAAVYAVRTITLLGVGPDK 396 Query: 430 AKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-----LPVVAKGDELLCEKGEVVERQ 484 +F AK + L GWR LL + +E+ + TP +P + L GEV+E++ Sbjct: 397 KPLRFGAKGKLLNVPGWRKLLQGDDAEEQKNETPSNPIPIPALEPRQILKVYSGEVLEKK 456 Query: 485 TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKK 544 T PP+ FTDA+L+ M G+G ++ A I++ + +G + K Sbjct: 457 TTPPKRFTDASLVGEMK-----------------RRGIGRPSSYASIVKNIIDKGQVQMK 499 Query: 545 GRYIHSTDAGKA----LFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 GR + + G+A L H+ ++ D T + E L +I+ + Y + +Q Y Sbjct: 500 GRSLIPGELGEATIALLEHNFSFLSL--DFTRNLEVALDRIANSEDTYMNVVQ----QFY 553 Query: 601 QLIDQAKRT 609 QL+ +T Sbjct: 554 QLLQTELQT 562 >UniRef50_Q4J922 DNA topoisomerase n=3 Tax=Sulfolobus RepID=Q4J922_SULAC Length = 668 Score = 138 bits (347), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 168/626 (26%), Positives = 260/626 (41%), Gaps = 112/626 (17%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCI-------------GHLLEQA 49 L IAEK AR IA+ L + + C V W + GHL Sbjct: 11 LVIAEKSKAARKIAEAL------SNNYSYCKKFYVNFWIVNYSSKYYIISPAAGHLFNLY 64 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQL-NVIKRFLHEASEIVHAGDPDREG 108 ++ W P+ WQ+ P TK+ ++IK +A E ++A D D EG Sbjct: 65 GNSSFPVYETEWK----PL----WQIDPSARYTKKYYDLIKSLSKDAQEFINACDYDIEG 116 Query: 109 QLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPL----CVSALA 164 L+ ++++L ++ +R + L + D L S PL + +A Sbjct: 117 SLIGYLIINFLG----DIKRAKRAKFSALTKE------DILNSFRNLKPLDYDMIHAGIA 166 Query: 165 RARADWLYGINMTRA-----YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAK 219 R + DWL+GIN++RA YT+ + +LS GRVQ+P L V+ + E FV Sbjct: 167 RHKVDWLWGINVSRALMKSVYTLTRKRV----ILSAGRVQSPTLIHVINNTVKRELFVPL 222 Query: 220 DFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLH--RPLAEHVVNRISGQPAIVT 277 ++ + I E I + E ++E + L + + E V I + A++ Sbjct: 223 PYYSINLTINLKNKEFKITIPKTFEN----KNEAKQYLEEIKKVGEVTVTNIELKDAVIY 278 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 P PF+L+ LQ+EA + FG S V + + LY + LI+YPR++ + +P Sbjct: 279 R----------PPPFNLTDLQLEAGRLFGYSPYLVERLAENLY-LNGLISYPRTNSQKIP 327 Query: 338 EEHFAGRHAVMNAISVHA-----PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA 392 + +++++S + L Q I + +K AH AI PT Sbjct: 328 PS--VNIYQIIDSLSKSKRYGSLINTLSQITKGKYIVRQ--GEKDDPAHPAIYPTGE-LP 382 Query: 393 INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARF--LAEAGWRTLL 450 NL E K+Y LI R++L DA RK I L I K K L GW L Sbjct: 383 YNLDTKELKLYELILRRFLASMSTDARVRKQEITLRIPKVDIELKLNIQSLIYKGWIILY 442 Query: 451 -GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQP-PRHFTDATLLSAMTGIARFVQ 508 +K DEE L V KGD+ + + T+P + + LL M Sbjct: 443 PYTKFSDEE-----LLDVKKGDKGRIVRANSTMKVTKPDTQRVSKIQLLKWM-------- 489 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY-------IHSTDAGKALFHSL 561 ++ LGTEATR IIE LFKR +L KG+Y I TD + F L Sbjct: 490 ---------ESNNLGTEATRGRIIETLFKRKYLMSKGKYAYPTPIGIVVTDVLSSYFKDL 540 Query: 562 PEMATRPDMTAHWESVLT-QISEKQC 586 ++ +M +++ + SE + Sbjct: 541 TDVRLTSEMEKKLNGIISGKFSENEV 566 >UniRef50_Q6N2B4 Possible DNA topoisomerase n=1 Tax=Rhodopseudomonas palustris RepID=Q6N2B4_RHOPA Length = 636 Score = 137 bits (346), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 94/295 (31%), Positives = 152/295 (51%), Gaps = 20/295 (6%) Query: 306 GLSAQNVLDICQKLYETH--KLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPV 363 G A L++ Q+LY+ K+ITYPR++ RYLP+ A ++ + V PV Sbjct: 107 GWPAGKTLEVAQELYDGQGKKIITYPRAEVRYLPQSLIADVPRIVAGLRV-GQSFGAIPV 165 Query: 364 VDPDIRNR----CWDDKKVD--AHHAIIPTARSS------AINLTENEAKVYNLIARQYL 411 +P + R + DK ++ +HHAIIP + L+ +E K++++IAR YL Sbjct: 166 PEPPVIRRGASGSFHDKGLEGASHHAIIPNVNTIDKLPEICPRLSSDEKKLFDVIARAYL 225 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAK 469 PD +R+ LD+ +F A R E GWR + EE ++ LP + Sbjct: 226 AALMPDFRYRQTTATLDVRGYEFRAAGRQPIELGWRAAFPEWQPAEEKGDEAQLLPPLRD 285 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + ++ +++T+PP + + TL+ AM RFV+D L++ L+ G+GT ATRA Sbjct: 286 GETAKLQDPKIEDKETRPPPRYNEGTLIEAMQNAWRFVEDGALRERLKEAKGIGTPATRA 345 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQI 581 II L K+ FL +G++I T+AG +LF L + P +TA E +L + Sbjct: 346 EIIGGLKKQAFLVIQGKHIVPTEAGLSLFGILQQADPALVDPGVTAQLECLLDDV 400 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 136 bits (342), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 141/552 (25%), Positives = 246/552 (44%), Gaps = 70/552 (12%) Query: 83 KQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQ-VQRCLINDLNPQA 141 K+L+ I + EA ++ A DPDREG+ + VL+ L+ + + ++R + N + + Sbjct: 60 KRLSEIASAVKEADRLILATDPDREGEAISWHVLEVLKKKRVLKDKKIERVVFNAITKSS 119 Query: 142 VERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTP 201 + A+ R E PL + LAR D+L G ++ +L R G S GRVQ+ Sbjct: 120 ILEAMKNPRELDE--PLVDAYLARRALDYLVGFTLS---PVLWRK--LPGARSAGRVQSV 172 Query: 202 VLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD----ERFTAI-WQPSEACEPYQDEEGRL 256 L LV +R+ EIE F +++++ + A++ TP + R T Q + ++E Sbjct: 173 ALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQARLTGFDGQKITRLDIKNEQE--- 229 Query: 257 LHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDIC 316 A + + G V++ K + + PF+ S LQ EA+++ G +A + + Sbjct: 230 -----ATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQEASRKLGFAAARTMQVA 284 Query: 317 QKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIR 369 QKLY ET LITY R+D + +E V+ S + + +P+ + Sbjct: 285 QKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVI--ASRYGDEYVPE-------K 335 Query: 370 NRCWDDKKVD---AHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFR 421 R + K + AH AI PT R A L E+ A++Y LI ++ + AV Sbjct: 336 PRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAVLE 395 Query: 422 KCVIELDIAKGKFVAKARFLAEA----GWRTLLG-SKERDEENDGTPLPVVAKGDELLCE 476 + +++D G A R G+ TL K+ +E+ + LP + +GD L + Sbjct: 396 RTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLGRK 455 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 E + T+PP FT+ATL+ M + G+G +T A ++ L Sbjct: 456 GIEANQHFTEPPPRFTEATLVKKMEEL-----------------GIGRPSTYAATLQTLR 498 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQ 593 RG++ + + D G+ + L + R D TA E L +IS ++ ++ Sbjct: 499 DRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLR 558 Query: 594 PLVGTLYQLIDQ 605 +++ D+ Sbjct: 559 DFWNPFHEICDE 570 >UniRef50_C4GAJ6 DNA topoisomerase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GAJ6_9FIRM Length = 770 Score = 136 bits (342), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 81/235 (34%), Positives = 126/235 (53%), Gaps = 14/235 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 LFIAEKPS+AR A L + + DG++E G +VTWC+GHL+ + P+AYD +W Sbjct: 5 LFIAEKPSVAREFASALGENTSRRDGYLE-GEHLIVTWCLGHLITMSYPEAYDPGLKKWR 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP +PE ++ + P+ +Q ++ L+ + I D REG+ + V Q Sbjct: 64 MDTLPFIPETFRYEVLPNSARQYQIVASLLNRSDVDTIYVCTDSGREGEYIYRLV---AQ 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 A + + +R I+ + + R I R S++ L SA RA+ D+L GIN +R Sbjct: 121 EAGVQDKVQKRVWIDSQTREEILRGIKEARDESDYDHLAASAYLRAKEDYLMGINFSRIL 180 Query: 181 TILGRNA-------GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 ++ +A GY + SVGRV + VLG+VVRR+ EI +FV F+ V + Sbjct: 181 SLKYGSAIANMLKEGYSSI-SVGRVMSCVLGMVVRREREIRDFVKTPFYRVLGDV 234 Score = 132 bits (333), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 110/409 (26%), Positives = 190/409 (46%), Gaps = 55/409 (13%) Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP---- 337 K+E ++ PL ++L+ +Q + ++ F +S L I Q+LYE KL+TYPR+D R L Sbjct: 357 KKEKKNPPLLYNLAEIQNDCSRFFKISPDETLAIIQELYE-KKLVTYPRTDARVLSTAVA 415 Query: 338 ---EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI- 393 +++ G A + + ++L Q + + R DDKK+ H+A+IPT + Sbjct: 416 KEIDKNIRG-LAGIPGVRTFVREILDQGLYKGIAKTRYTDDKKITDHYALIPTGQGLGAL 474 Query: 394 -NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-- 450 + A VY +I R++L F AV+ K + + F A ++L E G+ ++ Sbjct: 475 GRMPRRAAMVYEIIVRRFLAIFYDPAVYEKLNLTVCAWGESFFASDKYLVEEGYLKVMHY 534 Query: 451 ---------GSKERDEENDGTP------------------------LPVVAKGDELLCEK 477 G KE +EE +G LP + KGD + Sbjct: 535 SFQKKEGGSGRKE-EEEQEGNAIGQDETKKDDAEDSRENQALLARLLPKLKKGDPVCFLA 593 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 V E +T PP+ + +L+ AM + ++D++L+ ++ + G+GT ATRA I+ L + Sbjct: 594 FCVKEGETSPPKRYNSGSLILAMENAGQLIEDEELRAQIK-SQGIGTSATRAEILNKLIR 652 Query: 538 RGFLT--KKGRYIHSTDAGKALFH----SLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 +L+ KK + I T G+ +F S+P+M ++TA WE LT ++E ++ Sbjct: 653 ISYLSLNKKTQIISPTLRGELVFDVIAASMPQMLN-AELTASWEKGLTYVAEGTISEDEY 711 Query: 592 MQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 M+ L + +D+ K + G S K K + R+ KK Sbjct: 712 MKKLDAFIRLRVDRVKAMQNQSLLGSQFAAVAASYPKPKGNVKTRAVKK 760 >UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1AJN1_UREP2 Length = 681 Score = 135 bits (341), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 156/636 (24%), Positives = 275/636 (43%), Gaps = 99/636 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ ++I L GD + V+ C GHL E A+ YD + Sbjct: 9 LIVVESPNKIKSIQSYL------GDSY------NVIATC-GHLRELAKKSGYDPK----- 50 Query: 63 LADLPIVPEKWQL----QPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 DL KW++ + S +Q+ I +++ I A DPDREG+ + V D Sbjct: 51 TYDL-----KWEIIKTTNKKLSKKQQIKTIIDLAKKSNNIYLATDPDREGEAISWHVYD- 104 Query: 119 LQLAPEK-RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L P+K +++V+R N++ +A+ ++ID + + +F L S AR D + G Sbjct: 105 --LLPKKDKERVKRITFNEITQKAILKSIDE-KHDIDF-NLVDSQFARRILDRVIG---- 156 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 Y + G LS GRVQ+ L VV R+ E +FV +++++++ I F Sbjct: 157 --YKLSGLVKKNLHGLSAGRVQSIALLFVVERELERRSFVKEEWYQIEGII---EKNIFV 211 Query: 238 AIWQPSEACEPYQ-----DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 ++ + E Y D + + LH+ A+ V++ +S + + + K LP Sbjct: 212 SLRKIPYDVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDIFKVYSIDDLKITKGDVQLPL 271 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHK-------LITYPRSDCRYLPEEHFAGRH 345 + L A+ FG SA I Q+++E + LITYPR+D L ++ + Sbjct: 272 TTDKLLQIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRTDSERLSDDFLQEAN 331 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKV---DAHHAIIPTARSSAINLTENEAK- 401 A + + + L + +N+ + K+V DAH AI P INL E K Sbjct: 332 AFIE--NNFGKEYLE------NFKNKKINRKEVNIQDAHEAIRPVD----INLKPEEIKD 379 Query: 402 --------VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK 453 +YNL+ + L F K VI + KF + + G+ L K Sbjct: 380 YVSLDIYKLYNLVWNKTLSALMKVPTFNKQVIRFINNEYKFYTAYKTIRTLGYWILDFYK 439 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 ++ +E + P P++ GDE EK ++++++T PP ++T+A+L++A+ Sbjct: 440 KQRDELEFQP-PIINVGDEFKKEKIDLIQKETTPPPYYTEASLIAALKNA---------- 488 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDM 570 G+G +T A + + RG++ K + T+ G + L E Sbjct: 489 -------GVGRPSTYATMATIGTTRGYINKDKSKLIPTELGIKVIQELKEAFPKVISIKF 541 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 T+ E L I+ + ++D + + + + QA Sbjct: 542 TSEMEERLDVIANGKLFWKDLVSTFIPIFEEEVKQA 577 >UniRef50_D2RGC8 DNA topoisomerase n=2 Tax=Archaeoglobaceae RepID=D2RGC8_ARCPR Length = 648 Score = 134 bits (338), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 158/619 (25%), Positives = 273/619 (44%), Gaps = 76/619 (12%) Query: 1 MRLFIAEKPSLARAIADVLPK-----PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 M L +AEK AR IA +L K + + + N V GH++E P+ + Sbjct: 1 MWLIVAEKDKSARRIARILFKDVKVLKKNQVNYYFSPSNKAFVLGLKGHIVEYDFPEELN 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 + W L + + + +++ +A + A D DREG+ + Sbjct: 61 N----WRRTPLEALLKAKFVVKVKEKNVVKTLLE-LAKDAERVTIATDYDREGEFIGLTA 115 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + +Q +++R + L P V RA + S + L SA R + D L+G Sbjct: 116 VKLIQKV-NPGVKIERVRFSALTPVDVRRAFEN--PTSLDLNLAKSAEVRHKVDLLWGAI 172 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 +TR ++ G + LSVGRVQ+P L L+V R+E+I++F +K ++ A + Sbjct: 173 LTRLLSLSANRLG-RDFLSVGRVQSPTLRLIVEREEQIKSFKSKYYYN--------AFVK 223 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 I+ A ++ EE A+ V+ I+ V S+ E P+PF+ + Sbjct: 224 VRGIY----AKRKFEKEEE-------AKAVLESINTLK--VLSFKKSVVEEKKPIPFNTT 270 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM---NAIS 352 EA+K + + I + LY I+YPR+D P+ + M + Sbjct: 271 EFLKEASK--FMKPDKAMAIAENLY-MEGYISYPRTDNTVYPKTLNLKKLVEMFLSSDFK 327 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 HA +L ++P R R K+ H I PTA +S L+++E +Y L+ +++L Sbjct: 328 DHAEFVLKHG-IEPS-RGR----KETSDHPPIHPTAVASKDELSKDEWTIYELVVKRFLA 381 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 P A + +E + F A + L AGWR + + +E + +P G+ Sbjct: 382 TLAPKAKWEVKRVEFEQG---FKAMGKKLIFAGWRLIYDYSKPEE----SYIPDFKVGEV 434 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L+ E+ ++ + +T+PP +T TL+ M + GLGT++TR II Sbjct: 435 LVVEEKKIKKEKTKPPSRYTTGTLIKVMESL-----------------GLGTKSTRHEII 477 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRYQ 589 + L+ R ++ G I T+ A+ ++L E A T PDMTA E +T I+E + + Sbjct: 478 KKLYDRKYIY--GNPIRPTNLAFAVINALKETAEVVTLPDMTAKLERDMTAIAEGRIDEK 535 Query: 590 DFMQPLVGTLYQLIDQAKR 608 D ++ V L +++ R Sbjct: 536 DVLKESVVFLSRILKSVDR 554 >UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Entamoeba RepID=B0EMC7_ENTDI Length = 607 Score = 134 bits (336), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 170/648 (26%), Positives = 273/648 (42%), Gaps = 84/648 (12%) Query: 3 LFIAEKPSLARAIADVLPKPH-RKGDG-------------FIECGN-GQVVTWCIGHLLE 47 L +AEKPS+A AI+ L + +K G F G VT GHL Sbjct: 5 LHVAEKPSVANAISYTLSRGQCQKTSGLSKYNSIFEFEKEFKNIGKCTHYVTSVAGHL-- 62 Query: 48 QAQPDAYDSRYARWNLADLPIVPEKWQLQP----RPSVTKQLNV-IKRFLHEASEIVHAG 102 + + + Y W D PE+ P P+ K++ + +K + +V Sbjct: 63 --KGIDFTTAYRSWGSCD----PEELFTAPIEKSVPASMKKVELNLKNVAKKCQVLVLWL 116 Query: 103 DPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSA 162 D DREG+ + EV++ K +V R N L P + +A + L + + + V Sbjct: 117 DCDREGENISFEVIEVCSEVNSK-MKVWRAHFNSLVPDEIIKAYNTLTAPNRHMSEAVDV 175 Query: 163 LARARADWLYGINMTRAYTILGRNA--GYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAK 219 R D G TR T L +N +G VLS G Q P LG VV R +I+ F + Sbjct: 176 --RQEIDLRTGAAFTRFQTTLLKNKSKALEGKVLSYGACQFPTLGFVVDRYYQIKAFTKE 233 Query: 220 DFFEVKAHIVTPADERFTAI-WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTS 278 F+ K + V + T W + + RL+ L E + I+ A +T Sbjct: 234 TFY--KINCVVEKNSILTEFHWDRNRLFD-------RLICDLLYEDALEHINS--ATITE 282 Query: 279 YNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPE 338 +K + PLP + LQ +K F +S+ + I +KLY + LI+YPR++ P Sbjct: 283 ILEKSRTNFKPLPLTTVDLQKACSKYFKISSNETMTIAEKLYNS-GLISYPRTETNIFPS 341 Query: 339 EHFAGRHAVM---NAI-SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN 394 + + M N I S + +LL + +P RN DK +H I PT ++ + Sbjct: 342 DMDHEKQIKMFQENRIYSSYVQELLNGKIKNP--RNGKATDK---SHPPIHPTRNANLND 396 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSK 453 L+E E K+Y+ I R YL DA + I L + F + E + + K Sbjct: 397 LSEKERKIYDFIVRNYLANMSDDARGFETKIGLQVGNESFHCNGLMITERNYLNIFPFRK 456 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 D+E +P +G+++ EV +T PP+ T+ L+ M DK Sbjct: 457 WSDKE-----IPEFHEGEKVQLNCFEVSYGETSPPKPLTEPELIQLM--------DK--- 500 Query: 514 KILRATDGLGTEATRAGIIELLFKRGF-LTKKGRYIHSTDAGKALFHSLPEMA---TRPD 569 +G+GT+AT A I+ + +R + + K+G +I T+ G AL M +RP Sbjct: 501 ------NGIGTDATIAQHIQKIQEREYVIVKQGSFI-PTNLGLALVEGYDSMGFEFSRPQ 553 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI 617 + A E LT+I + D + + +L ++A+ + I Sbjct: 554 LRAETEKELTKICSGESNKDDVISTFIEQYEELYERAQYNKSKLVNAI 601 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 133 bits (334), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 170/641 (26%), Positives = 271/641 (42%), Gaps = 113/641 (17%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ A++I L G G V GH+ + D A Sbjct: 1 MYVVIVESPAKAKSINKYL-------------GKGYEVYPSYGHVRDLPAKDGSVDPDAD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + W + + + K+LN I R + +A +I+ A DPDREG+ + VL+ L+ Sbjct: 48 FAML--------WDVDVKSA--KRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLK 97 Query: 121 LAPE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 K + V+R + N + AV A+ R V L + LAR D+L G N++ Sbjct: 98 AKKVLKDKPVERVVFNAITKSAVLEAMQHPRQID--VALVDAYLARRALDYLVGFNLS-- 153 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA- 238 +L R G S GRVQ+ L LV R+ EIE FVA++++ + AH+ T AD FTA Sbjct: 154 -PVLWRK--LPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTAR 210 Query: 239 -------------IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 + +EA D E A V I +PA KR Sbjct: 211 LVGADGKKITRLDVGTGAEAAAFKTDLEN-------ATFRVAEIEAKPA-------KRHP 256 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPE 338 + PF+ S LQ EA+++ G + + + Q+LY ET LITY R+D L Sbjct: 257 SA---PFTTSTLQQEASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAP 313 Query: 339 EHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAI 393 E A+ +A SV A V + +AH AI PT R+ A Sbjct: 314 E------AITSARSVIARQFGDAYVPKAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVAR 367 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTL 449 L ++AK+Y LI + + A + ++++ G A + + G+ L Sbjct: 368 ALEPDQAKLYELIWTRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKL 427 Query: 450 LG-SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 ++ +++++ LP +AK + L E+ E + T+PP FT+ATL+ M + Sbjct: 428 YQEGRDDEDDDESARLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEEL----- 482 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR- 567 G+G +T A + +L +R ++ + + +H D G+ + L R Sbjct: 483 ------------GIGRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARY 530 Query: 568 --PDMTAHWESVLTQISEKQCRYQ--------DFMQPLVGT 598 D TA E L ++S + ++ DF L GT Sbjct: 531 VGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGT 571 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 131 bits (330), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 161/586 (27%), Positives = 259/586 (44%), Gaps = 85/586 (14%) Query: 53 AYDSRYARWNLADLPI----VPEKWQLQPRPSVTKQLNVIKRFLHEASE---IVHAGDPD 105 Y+ R ++ ++ADLP V + P+ +V K I L A+ ++ A DPD Sbjct: 25 GYEVRASKGHIADLPEHELGVDTQADFAPQYTVKKDKQPIVEELKRAARGKRVLIATDPD 84 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 REG+ + V L L P+ +V+ +++ P+ V A+ + R + L + AR Sbjct: 85 REGEAIGWHVARLLGLNPQTPLRVE---FHEITPKVVRAAVQKPRPIDQ--SLVDAQQAR 139 Query: 166 ARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK 225 D L G ++ ++ R LS GRVQ+ L L+V R++EIE FV ++ + ++ Sbjct: 140 RVLDRLVGYQLSPVLSMEFRRR----ALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLE 195 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYN----D 281 + ++F A+ S E Q + L+ +E I+ V+ Y + Sbjct: 196 GRFESEG-QQFKAMLY-SLGSERVQSGDKFLI---TSEKQAQEIARLAKDVSGYRIGSIE 250 Query: 282 KRESE-SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDC 333 +RE +AP PF S LQ A+ R G +A + + QKLYE T LITY R+D Sbjct: 251 RRERRRNAPPPFITSTLQQAASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDS 310 Query: 334 RYLPEEHFAGRHAVMNAISVH-APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA 392 + +E A V I H P LP+ P+ DAH AI PT+ Sbjct: 311 TRVSQEALA---EVRAFIPRHFGPAYLPE---KPNFFAGKKAANAQDAHEAIRPTSTERT 364 Query: 393 IN-----LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK------FVAKARFL 441 + L++ E ++Y LI ++++ AVF + + + A G F A L Sbjct: 365 PDALRKHLSDEEYRLYQLIWQRFVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVL 424 Query: 442 AEAGWRTLLGSKERDE-ENDGTPLPVVAKGDELLCEKGEVVERQ--TQPPRHFTDATLLS 498 G+ + G +E DE EN PL A L EV Q T+PP +TDA+L+ Sbjct: 425 KFDGYLRVYGREEGDEAENRLPPLQENASARLL-----EVTPEQHFTEPPPRYTDASLVK 479 Query: 499 AMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA-- 556 + + G+G +T A I+ L +RG+L + G+ + T G+ Sbjct: 480 TLEEM-----------------GIGRPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVT 522 Query: 557 --LFHSLPEMATRPDMTAHWESVLTQISEKQCRY----QDFMQPLV 596 L S P++ D TA ES L +I E + + ++F +P + Sbjct: 523 GYLIKSFPDVVAY-DFTAQLESRLDEIEEGKAAWPKVVREFYEPFL 567 >UniRef50_Q702B0 DNA topoisomerase n=1 Tax=uncultured crenarchaeote RepID=Q702B0_9CREN Length = 715 Score = 131 bits (330), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 151/641 (23%), Positives = 272/641 (42%), Gaps = 94/641 (14%) Query: 2 RLFIAEKPSLARAIADVL------PKPHRKGDGFIECGNGQ----VVTWCIGHLLEQAQP 51 +L I EKP A+ I+ VL K + G E + + VV +GH+ Sbjct: 13 QLVICEKPLAAKRISQVLGSKNIIEKKYSLGIVVFEITSDKNQRFVVCSALGHMYSLIPL 72 Query: 52 DAYDSRYARWNLADLPIVPEKWQ------LQPRPSVTKQLNVIKRFLHEASEIVHAGDPD 105 + +Y PI W R + + L VI R AS +HA D D Sbjct: 73 EKNRKKY--------PIYETVWSPKHSTVANQRKRILETLKVIARISEGASGYIHACDYD 124 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 EG+L+ +L+Y K +Q +R + L + ++ + L+ + + + AR Sbjct: 125 LEGELIGYNILEY--ACKHKYEQSRRAKFSSLTDSEINQSFNNLQQTD--IRIAEAGKAR 180 Query: 166 ARADWLYGINMTRA----YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF 221 D+++GIN++RA ++ ++ Y LS+GRVQ P LG +V R+ Sbjct: 181 HLVDFVFGINLSRALVNCLSVANQDNRYYN-LSIGRVQGPTLGFIVDRE----------- 228 Query: 222 FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHR-PLAEHVVNRISGQPAIVTSYN 280 +++ H+ P T +Q + +Q +H+ + ++ A + + Sbjct: 229 IKIRKHVPDPV-WYITGNFQKDNS--SFQANLSTAIHKFSEMQKILATCKNGKATIKTVI 285 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 + + + P PF+LS LQ EA + F LS I + LY LI+YPR+ + LP Sbjct: 286 CQTKKVNPPTPFNLSDLQKEAFRIFKLSPAVTHSIAESLY-LAALISYPRTSSKKLPSS- 343 Query: 341 FAGRHAVMNAISVHAP--------DLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSS 391 G ++N +S + +LL Q + P + + D AH AI PT Sbjct: 344 -IGYEKILNLLSKNYATADKNKIQELLMQKYLVP------FQGIEEDPAHPAIYPTGLKH 396 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 L+ ++K+ +LI +++L F A+ + + ++ F+AK + GW L Sbjct: 397 K-KLSVQQSKILDLIIKRFLATFGDGALTNFSEVIITVSGYDFIAKGNTILNYGWIPLYE 455 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 +E T LP + KGD + +E T+P + A++L M Sbjct: 456 PYFSIKE---TRLPHLVKGDSAQTNEVTALEDFTKPVARYNQASILEKM----------- 501 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPD-- 569 ++G+GT++TRA + LL KR ++ + + T G + ++ + PD Sbjct: 502 ------ESEGIGTKSTRAETVNLLIKRNYILQHKIGLEPTVLGFTILDTMKKFI--PDIV 553 Query: 570 ---MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 +TA ES + ++ + + + + L +L + +++ K Sbjct: 554 STKLTAFLESSIKRVEQGELDMINLRKHLEKSLLKPLNRIK 594 >UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID=B9LRP1_HALLT Length = 864 Score = 130 bits (326), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 149/593 (25%), Positives = 250/593 (42%), Gaps = 106/593 (17%) Query: 3 LFIAEKPSLARAIADVLP----KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 L I EK + AR IAD+L R+ D + G+ GH++ P + Y Sbjct: 7 LIITEKDNAARRIADILSGESATAERENDVNVYKWGGKRCIGLSGHVVGVDFP----AEY 62 Query: 59 ARW------NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 W L D PI E P+ + +++ AS +V A D DREG+L+ Sbjct: 63 NDWRDVEPVELIDAPITKE-------PTQEGIVAALRKLARNASRVVIATDYDREGELIG 115 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA--DW 170 E + ++ E + R + + V A +N + + ++A AR D Sbjct: 116 KEAYELVREVNED-APIDRVRFSSITDNEVNEAF----ANPDELDFDLAAAGEARQVIDL 170 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 +G +TR ++ R G + +SVGRVQ P L L+V R+ EI+ F + ++E+ ++ Sbjct: 171 TWGAALTRFLSLSARQLG-EDFISVGRVQGPTLKLIVDREREIKAFDPEAYWELYGNLTK 229 Query: 231 PADERFTAIWQPSEACEPYQDEEG----RLLHRPLAEHVVNRI-SGQPAIVTSYNDKRES 285 + F A + Y ++EG R+ + +AE + + A+V + + Sbjct: 230 SGGDPFEARYF-------YLNDEGNEAERVWNGDVAEVLTEAFDAADEAVVDDVRRRTRT 282 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE----HF 341 + P PF+ +A I AA G SAQ + + + LY T +TYPR+D PE+ Sbjct: 283 DDPPTPFNTTAF-IRAAGSLGHSAQRAMSLAEDLY-TAGYVTYPRTDNTVYPEDLDPREL 340 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEA 400 +V + A LL Q ++P D++ H I PT SA +L+E+E Sbjct: 341 IEELSVASTFGKDAKSLLEQEEIEP-----TEGDEETTDHPPIHPTGELPSASDLSEDEW 395 Query: 401 KVYNLIARQYLMQFCPDAVFRKC-VIELD-----------------------------IA 430 +VY LI R++L A + + V+ L +A Sbjct: 396 EVYELIVRRFLATCAEPATWERLRVVALANDEATAIAERADGLAALRNPEEASGPGDLVA 455 Query: 431 KG--KFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPP 488 G + A + L EAG+ + + DE +P V G+ L ++TQPP Sbjct: 456 DGGLRLKANGKRLLEAGYHDVYPYRSSDER----IVPDVEVGETLALTDRRTDAKETQPP 511 Query: 489 RHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL 541 R + G +R +++ + + G+GT+ATR +E L+ R ++ Sbjct: 512 RRY----------GQSRLIEEMEKR-------GVGTKATRHRTLEKLYDRNYI 547 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 129 bits (325), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 152/635 (23%), Positives = 275/635 (43%), Gaps = 111/635 (17%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHL--LEQAQ-----PDAYD 55 L I E P+ A+ I L K ++ V +GH+ L ++Q D Y+ Sbjct: 5 LVIVESPAKAKTIEKYLGKKYK-------------VIASMGHVRDLPRSQMGVDVEDNYE 51 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 +Y ++ + V K L K++ +A + A DPDREG+ + + Sbjct: 52 PKYI--------------TIRGKGPVVKDL---KKYAKKAKNVFLASDPDREGEAIAWHL 94 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L+L K R + N++ AV+ + R + L + AR D L G N Sbjct: 95 SKILELDDSKEN---RVVFNEITKDAVKESFKHPRGIE--MDLVDAQQARRILDRLVGYN 149 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 ++ +L + + LS GRVQ+ L LV+ R+ EI NF ++++ ++ + Sbjct: 150 IS---PVLWKKV--KKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKS-K 203 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 FTA + Y+++ +L + E V + G +T+ N K ++ + PF+ S Sbjct: 204 FTAKFLH------YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTS 257 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAV 347 LQ EAA++ A+ + + Q+LYE T LITY R+D Sbjct: 258 TLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDS-------------- 303 Query: 348 MNAISVHAPDLLPQPVVDP----DIRNRCWDDKK--VDAHHAIIPTAR-----SSAINLT 396 IS A D Q + D + NR K+ DAH AI PT+ LT Sbjct: 304 -TRISQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLT 362 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 ++ ++Y LI +++ A+ +++ KF A + + G+ TL + D Sbjct: 363 RDQHRLYKLIWERFVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDD 422 Query: 457 EENDG-TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 ++N+ LP ++KGDE+ + E + TQPP +T+A L+ + ++LK Sbjct: 423 KDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPRYTEARLVKTL---------EELK-- 471 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMT 571 +G +T A I+ + KR ++ + + T+ G+ ++ + PE+ + T Sbjct: 472 ------IGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIID-VEFT 524 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 + E++L +I+E ++ + G+ +++A Sbjct: 525 VNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERA 559 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 129 bits (324), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 168/634 (26%), Positives = 265/634 (41%), Gaps = 96/634 (15%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ IA L G+G V +GH+ + +P + Sbjct: 48 KLVIVESPAKAKTIAQYL-------------GSGYEVQASVGHIRDLIEPKNLPPELKKG 94 Query: 62 NLADLPIVPEKWQLQPRPSVTKQ----LNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 L + E +P V+ Q + +KR L +A E+ A D DREG+ + +L Sbjct: 95 TLGKFSVDVENG-FEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWHLLQ 153 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ + V+R + +++ +A+ERA D R L + R D LYG ++ Sbjct: 154 VLK----PKVPVKRMVFHEITKEAIERARDSTRDID--TALVDAQETRRILDRLYGYEVS 207 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV-----TPA 232 +L R G LS GRVQ+ LVV R+ E FV ++++ A + P Sbjct: 208 ---PVLWRKVGPG--LSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPF 262 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLH--RPL------AEHVVNRISGQPAIVTSYNDKRE 284 D R I A D++G L + RPL A R P V S K Sbjct: 263 DARLVRIDGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPY 322 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 + PF+ S LQ EAA++ SA+ + + Q LYE + ITY R+D L ++ A Sbjct: 323 TRRPAAPFTTSTLQQEAARKLRFSARQTMSVAQSLYE-NGYITYMRTDSPSLSQQ--AIN 379 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVD---AHHAIIP------TARSSAINL 395 A A ++ P+ +P + R + K + AH A+ P T + A L Sbjct: 380 AARKQAAELYGPETVPD-------KPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTL 432 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAK--ARFLAEA---GWRTLL 450 N+ K+Y+LI ++ + DA + + IA G A A F A +R L Sbjct: 433 RGNDHKLYDLIWKRTIASQMADA--KGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFL 490 Query: 451 GSKE--RDEENDGTP------LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + E RDEE G LP + KG +L + +T PP +T+A+L+ + Sbjct: 491 AAYEESRDEERHGAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEE 550 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 + G+G +T A II + RG++T +G + ++ L Sbjct: 551 L-----------------GIGRPSTYAAIISTIVDRGYVTPRGTALVPNWIAFSVVRLLE 593 Query: 563 EMAT---RPDMTAHWESVLTQISEKQCRYQDFMQ 593 E T + D TA E L +I+E D+++ Sbjct: 594 EFFTELVQYDFTAGMEDDLDRIAEGAAERVDWLK 627 >UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_9BACT Length = 750 Score = 129 bits (324), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 138/535 (25%), Positives = 238/535 (44%), Gaps = 55/535 (10%) Query: 83 KQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAV 142 K++ IK FL++A +I A DPDREG+ + + + L L + Q +R N+++ +A+ Sbjct: 70 KRIEKIKAFLNKADKIYLATDPDREGEAISWHLKECLGL---EDGQFERIEFNEISEKAI 126 Query: 143 ERAIDRLRSNSEFVPLCVSALARARADWLYGINMT-RAYTILGRNAGYQGVLSVGRVQTP 201 + AI+ R L + AR D L G ++ A ++G+ + S GRVQ+P Sbjct: 127 KEAINNGRGLD--YQLVYAQEARRALDRLVGYLVSPMASNLMGQPS------SAGRVQSP 178 Query: 202 VLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPL 261 + +VV R+ EI+ F + F V +++ + W +E +++ +L R L Sbjct: 179 AVLIVVLREIEIQKFKVTNHFGVNLSF-DKEPKKWISQWVTTEFV---TEDQPYVLDRSL 234 Query: 262 AEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE 321 AE V + V + +K E +AP PFS + L A+ G S Q Q L+E Sbjct: 235 AEEVAKT---KKVKVLNCTEKTEYSNAPSPFSTALLLQAASVALGFSPQQTTKAAQALFE 291 Query: 322 THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAH 381 ITY R+D + +E A N P+ P + D +AH Sbjct: 292 -QGAITYIRTDGLNIADESVEEIFAYANEHQFSLPEK-PNKFKEKDGAQ--------NAH 341 Query: 382 HAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL--DIAKGKFVAKA 438 AI P + + + + +Y LI + + A ++ +EL + K KF AK+ Sbjct: 342 EAIRPVHITDKDLGKSPEQKALYQLIWERTISSQLAKAEYKAVTLELLSEDGKYKFHAKS 401 Query: 439 RFLAEAGWRTLLGSKERDEENDGTPL-PVVAKGDELLCEKGEVVERQTQPPRHFTDATLL 497 R L + GW ++EN+ + + PV+ G + E GEV+ +QT+PP+ +T+A+L+ Sbjct: 402 RELIKKGWMVFGKDCLNEDENEPSGVVPVLEVGSVVDVESGEVIAKQTKPPKRYTEASLI 461 Query: 498 SAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKAL 557 + G+G +T + I+ + +GFL + + + T G L Sbjct: 462 KKLESC-----------------GIGRPSTYSSIMANILNKGFLEVEKKVLKPTKLGNDL 504 Query: 558 FHSLPEMATRPDMTAHW----ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 SL + A + H+ E L +I+ + Y + L L Q + A + Sbjct: 505 IGSLLK-AKFSFLDLHYSKEMELQLDKIASGETSYNSVVSALYTQLAQELSTASK 558 >UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7J0A2_ORYSJ Length = 928 Score = 129 bits (323), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 164/624 (26%), Positives = 264/624 (42%), Gaps = 96/624 (15%) Query: 3 LFIAEKPSLARAIADVLPKPH---RKGDG---------FIECGNGQ----VVTWCIGHLL 46 L +AEKPS+A+++A++L +P R +G F G+ +VT GHL+ Sbjct: 13 LNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTGHLM 72 Query: 47 EQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASE----IVHAG 102 E +D R+ RW+ D + + R SV + IKR L E + +V Sbjct: 73 ELE----FDDRFRRWHSCD---PADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWL 125 Query: 103 DPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRL-RSNSEFVPLCVS 161 D DREG+ + EV+D A R + R + L + + A+ L R N F + Sbjct: 126 DCDREGENIAYEVIDICAGA-NSRLNIWRARFSALIDREIHEAVQHLDRPNKLFAD---A 181 Query: 162 ALARARADWLYGINMTRAYTILGRNA--------GYQGVLSVGRVQTPVLGLVVRRDEEI 213 AR D G + TR T+L ++A +LS G Q P LG +V R EI Sbjct: 182 VDARQEIDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEI 241 Query: 214 ENFVAKDFFEVK-AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ 272 + ++F+ + +H F I G L A + + Sbjct: 242 QAHEPEEFWTINCSHTSDEGTASFGWI-------------RGHLFDYSSAVVIYEMCVEE 288 Query: 273 P-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRS 331 P A V + ++ + + P P S LQ A++ F +S+++ + + ++LY+ I+YPR+ Sbjct: 289 PMATVQNVRNQEKLKYPPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQA-GFISYPRT 347 Query: 332 DC-RYLPEEHFAGRHAVMNAISVHAP-DLLPQPVVDPDIR------NRCWDDKKVDAHHA 383 + + P H++++ H Q ++DP+ R N DDK AH Sbjct: 348 ETDNFSPNTDL---HSIVHEQVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDK---AHPP 401 Query: 384 IIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLA 442 I PT S+ N T+N K+Y L+ R +L AV + +E+DIA +F A R + Sbjct: 402 IHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVL 461 Query: 443 EAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + + R + GT LP G + + + T+PP +A LL M Sbjct: 462 AKNYLDVY----RFDSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCM-- 515 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHS-TDAGKALFHSL 561 DK G+GT+AT I+ L R + TK S T+ G+AL Sbjct: 516 ------DK---------AGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGY 560 Query: 562 PEMAT---RPDMTAHWESVLTQIS 582 EM +P + + E+ + +S Sbjct: 561 DEMGYELWKPYLRSMMEADMKSVS 584 >UniRef50_Q9YB01 DNA topoisomerase 1 n=1 Tax=Aeropyrum pernix RepID=TOP1_AERPE Length = 673 Score = 129 bits (323), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 167/639 (26%), Positives = 264/639 (41%), Gaps = 106/639 (16%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCI-------------GHLLEQAQ 50 +AEKP A IA L G G + C V W + GHL Sbjct: 1 MVAEKPKAAAKIAYALSD----GRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHT 56 Query: 51 PDAYDSRYARWNLADLPIVPEKWQLQPRP---------SVTKQLNVIKRFLHEASEIVHA 101 DSR P+ +W RP ++K ++ R L AS V+A Sbjct: 57 ----DSR-------GFPVFDFEW----RPIFEFDRGAGYLSKFYRMLSRILPGASLYVNA 101 Query: 102 GDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS 161 D D EG ++ ++++ A + +R + L PQ + RA R+ V + + Sbjct: 102 CDYDIEGSVIGFKIIE----AFGDVNRARRMKFSTLAPQDIRRAYARMERLD--VEMIEA 155 Query: 162 ALARARADWLYGINMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKD 220 +AR+ DWL+GIN++RA R A + V LS GRVQ+P L RR EI V K Sbjct: 156 GMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKA 215 Query: 221 FFEVKAHIVTPADERFTAI---WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVT 277 VK F A W+P ++ E + + L P V Sbjct: 216 SVAVKI-TAEKGGGVFDARPHGWKP-QSLETARSIKSELRKNPWLA------------VE 261 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 +R P F+L LQ EA + GL I ++LY LI+YPR++ + LP Sbjct: 262 EVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELY-LEALISYPRTNSQKLP 320 Query: 338 EEHFAGRHAVMNAISVHAP------DLLPQP--VVDPDIRNRCWDDKKVDAHHAIIPTAR 389 A+++ ++ H P +LL + V+ P K AH AI PT Sbjct: 321 PS--INYRAILDKLA-HGPLGREARELLKETGGVLRP-----VQGSKDDPAHPAIHPTGE 372 Query: 390 SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRT 448 + L++ VY LI R++L F +A+ K + L +G+ + A+ + + GW Sbjct: 373 KPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLK 432 Query: 449 LLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 E+ P+P + +GD+ + +V +Q P A+LL M + Sbjct: 433 YYHYSTPGEK----PMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWMESV----- 483 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFL--TKKGRYIHSTDAGKALFHSLPEMAT 566 +GTE TRA IIE L+KRG+L ++K +A + +L + Sbjct: 484 ------------NIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELS 531 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 +PD+T +ES++ I + Q+ + T+ +L++ Sbjct: 532 KPDLTRRFESMIEDIRSGRRTRQEVIDMSKKTISKLLES 570 >UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID=Q18KP8_HALWD Length = 857 Score = 128 bits (322), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 162/618 (26%), Positives = 254/618 (41%), Gaps = 88/618 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTW----CIG---HLLEQAQPDAYD 55 L I EK + AR IAD+L D E G V W CIG H++ P Sbjct: 7 LIITEKDNAARRIADILSGDSATADR--EQGV-NVYKWGGKRCIGLSGHVVAVDFP---- 59 Query: 56 SRYARW------NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 Y+ W L D PI + P+ + +K+ A ++ A D DREG+ Sbjct: 60 QEYSDWRDVEPVELIDAPI-------EKNPTKQNIVTTLKKLARRARRVIIATDYDREGE 112 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAI---DRLRSNSEFVPLCVSALARA 166 L+ E + ++ E + R + + ++V A D L N L + AR Sbjct: 113 LIGKEAYELVRRVNES-TPIDRVRFSSITEESVTTAFENPDDLDFN-----LAAAGEARQ 166 Query: 167 RADWLYGINMTRAYTILGRNAGYQG--VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 D ++G +TR L +AG G +SVGRVQ P L L+V R+ EIE F +D++E+ Sbjct: 167 VIDLVWGAALTR---YLSLSAGQLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWEL 223 Query: 225 KAHIVTPADERFTAIWQPS----EACEPYQDEEGRLLHRPLAEHVVNRI-----SGQPAI 275 + T AD+ + EA Y ++G R E + S A Sbjct: 224 FVDL-TQADKPIEVSTDDTAAEFEAQYFYHADDGTEAERITEESTAKTVFETLESASIAH 282 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V S + ++ P PF+ + I AA G +AQ +DI + LY T ITYPR+D Sbjct: 283 VDSVKRRTRTDEPPAPFNTTQF-ISAAGSIGYAAQRAMDIAEDLY-TAGYITYPRTDNTV 340 Query: 336 LPEEHFAGR--HAVMNA--ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-S 390 P+E A+ N A D+L Q + P D++ H I PT Sbjct: 341 YPDELDPRELIEALTNGSRFGSDARDVLDQETLSP-----TTGDEETTDHPPIHPTDELP 395 Query: 391 SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKA--RFLAEAGWRT 448 L +++ +VY LI R +L A + I + I + K+ R L G+ Sbjct: 396 KPSELDDDKWEVYELIVRHFLATVSNPATWEHLRI-VAIVDDTYSIKSNGRRLLNPGYHA 454 Query: 449 LLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 + E + +P + G+ L + +QTQPPR + + L+ M + Sbjct: 455 VYPYSNATE----SLIPDIEDGETLRLIDSRIEAKQTQPPRRYGQSRLIETMESM----- 505 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEMATR 567 G+GT+++R +I+ L+ RG++ + R A E+ Sbjct: 506 ------------GIGTKSSRHNVIQKLYNRGYIESDPPRPTQLARAVVEAAEEFAELIVS 553 Query: 568 PDMTAHWESVLTQISEKQ 585 +MTA E+ + I+E + Sbjct: 554 EEMTAQLETDMQAIAEGE 571 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 126 bits (317), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 140/553 (25%), Positives = 244/553 (44%), Gaps = 94/553 (16%) Query: 92 LHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERA------ 145 + +A +++ A DPDREG+ + + + L++ + +++ N++ QA+++A Sbjct: 71 VKKADQVLIASDPDREGEAIAWHLQNLLEIDENESCRIE---FNEITKQAIQKALQHPRP 127 Query: 146 IDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGL 205 IDR R N++ AR D L G N++ +L R + LS GRVQ+ + L Sbjct: 128 IDRNRVNAQ--------QARRILDRLVGYNLS---PLLWRK--IKKGLSAGRVQSVAVRL 174 Query: 206 VVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHV 265 + R+EEI++FV ++++ + A V + F ++DE+ + + + V Sbjct: 175 ICDREEEIQSFVPEEYWTLVASFVKTGEAPFEG------RLIKFRDEKIDIPSKEKMQEV 228 Query: 266 VNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE---- 321 + + G V K +S PLPF S LQ EA ++ +A+ + + Q+LYE Sbjct: 229 LENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFTARKTMMVAQQLYEGLDL 288 Query: 322 ----THKLITYPRSDC------------RYLPEEHFAGRHAVMNAISVHAPDLLPQPVVD 365 T LITY R+D +Y+ E F R+A P V Sbjct: 289 GREGTSGLITYIRTDSTRVSASAREEAQKYIV-ERFGARYAGRET-----------PPVG 336 Query: 366 PDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 P R K DAH AI PT+ LT ++ K+Y LI ++L AVF Sbjct: 337 PAGRK----GKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAVF 392 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGW-RTLLGSKERDEENDGTPLPVVAKGDELLCEKGE 479 I++ + F A + G+ + S++ +E+ + LP + +G+E+ E Sbjct: 393 DTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEI--EARS 450 Query: 480 VVERQ--TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 + RQ TQPP +TDA+L+ A+ G+G +T A I+E + K Sbjct: 451 LTPRQHFTQPPPRYTDASLVRAL-----------------EEKGIGRPSTYAPIVETILK 493 Query: 538 RGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQP 594 RG++ ++ + T+ G + L + D TA E L I E + + ++ Sbjct: 494 RGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLES 553 Query: 595 LVGTLYQLIDQAK 607 G +++A+ Sbjct: 554 FYGPFKNTLEKAE 566 >UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genome shotgun sequence n=3 Tax=Paramecium tetraurelia RepID=A0CUH3_PARTE Length = 947 Score = 126 bits (316), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 146/624 (23%), Positives = 272/624 (43%), Gaps = 68/624 (10%) Query: 3 LFIAEKPSLARAIADVLPK---------PHRKGDGF-IECGNGQVVTW---CIGHLLEQA 49 L +AEKPS+AR+IA+VL + P+ K F + G+ +V W GHL Sbjct: 16 LNVAEKPSVARSIANVLARDHTVEETQSPYNKLFKFNFKFGDQEVEMWITSVTGHL---- 71 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQL--NVIKRFLHEASEIVHAGDPDRE 107 + Y +Y +W+ D I+ + +++ K+ +K+F E S+++ D DRE Sbjct: 72 KSLRYPKQYQKWDQWDPIIILKDAEIENIIPNEKRFLEGNLKQFARECSQLILWLDCDRE 131 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + EVL+ + + + QV R + + +++A+D L+ E L S LAR Sbjct: 132 GENIAFEVLEVCKDS-NPQIQVHRAHFSAVTYIDIKKALDNLKQPDE--NLSNSVLARQE 188 Query: 168 ADWLYGINMTRAYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 D G + TR T+L + + V+S G Q P LG VV+R +EI++FV + F+ ++ Sbjct: 189 IDLRIGASFTRFQTLLLQQQFHLQSVISYGPCQIPTLGFVVQRQKEIDSFVKEKFWFIQC 248 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 T Y G + + + R + A +T K + Sbjct: 249 EDQTKCG---------------YNWSRGNIFDEMIVLILFERCFTEQAKITDVQSKEVQK 293 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P P S + A+K+ +SA +++ +KLY I+YPR++ P ++ Sbjct: 294 WKPYPLSTIEFEKLASKKLKISAHKAMELAEKLY-NRGFISYPRTETNKFPPT-INLQNI 351 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYN 404 + + ++ Q +++ + +K AH I P R S T+ E ++Y Sbjct: 352 IRDQVNHPVWGEFAQSLINCNFDQPRAGNKDDKAHPPIHPVKMMRESDAQ-TQQEWEIYQ 410 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 LI R +L +A + + L + + F + + E + + E + + + Sbjct: 411 LITRHFLACCSKNAKGSETTVNLQVQEESFYKQGLVILEKNYLEIYPYDEWSQ----SQV 466 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P KGD ++ ++ +T PP+ T++ L+ M DK +G+GT Sbjct: 467 PNYKKGD-MIQITLKIQNGKTSPPKPMTESELIGLM--------DK---------NGIGT 508 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQI 581 +AT I + +R + KKG+ I T G AL S + +P + A E + ++ Sbjct: 509 DATIHEHINTIQEREYAIKKGQIIKPTKLGLALVESYEMLGFTLHKPHLRAVMEQRMNEV 568 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQ 605 ++ + + ++ + + ++ Q Sbjct: 569 AQGTKQKKQIVEATIAEMSDILKQ 592 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 125 bits (315), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 149/548 (27%), Positives = 240/548 (43%), Gaps = 85/548 (15%) Query: 94 EASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS 153 E ++ A DPDREG+ + V L P++ +V+ +++ P+ V +A++ R Sbjct: 85 EGKRLLIATDPDREGEAIGWHVARLLGRDPKEPLRVE---FHEITPRVVRQAVEAPRPID 141 Query: 154 EFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEI 213 + L + AR D L G N++ ++ R LS GRVQ+ L LVV R+E I Sbjct: 142 QN--LVDAQQARRVLDRLLGYNLSPLLSLEFRKR----ALSAGRVQSVALRLVVEREEAI 195 Query: 214 ENFVAKDFFEVKAHIVTPADER-FTAIWQPSEACEPYQ---DEEGRL-LHRPLAEHVVNR 268 E F ++++ ++ E A E + ++EGRL L H + Sbjct: 196 EAFRPEEYWVLRGVFAVEGGEAPLVATLHEVEGKRLWTGQGEKEGRLHLASEAEAHALAE 255 Query: 269 ISGQPAIVTSYNDKRESESAPLP-FSLSALQIEAAKRFGLSAQNVLDICQKLYE------ 321 + + + + RE AP P F+ S LQ A+ R G +A + I Q+LYE Sbjct: 256 ALRKGSYRVAQVEVRERRKAPPPPFTTSTLQQAASSRLGYTAARTMRIAQRLYEGVDLPE 315 Query: 322 -THKLITYPRSD-CRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKK-- 377 T LITY R+D R PE A R + A P+ LP+ R + +++ Sbjct: 316 GTVGLITYMRTDSVRVAPEAVAAAREVIGKAF---GPEYLPEA-------PRAYKNRREG 365 Query: 378 -VDAHHAIIP-----TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAK 431 DAH AI P T S L+E E ++Y LI R++L DA++ + + L + Sbjct: 366 VQDAHEAIRPTDPKRTPESVRPYLSEEEYRLYELIWRRFLASQMRDALYEQTAVTLADLE 425 Query: 432 GK--FVAKARFLAEAGWRTLLG-------SKERDEENDGTPLPVVAKGDELLCEKGEVVE 482 G+ F A L G+ G +G P A+ +E+L E+ Sbjct: 426 GRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVP----ARLEEVLEER----- 476 Query: 483 RQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLT 542 R T+PP +TDA+L+ M + G+G +T A +E L KRG++ Sbjct: 477 RFTEPPPRYTDASLVKTMEEL-----------------GIGRPSTYAPTLETLEKRGYVA 519 Query: 543 KKGRYIHSTDAGKA----LFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ----DFMQP 594 +KGR + T G+ L P++ + TA E L ++ E + + +F +P Sbjct: 520 RKGRTLFPTPLGRQVTAYLRERFPQVVAY-EFTARMEERLDEVEEGRVPWPKVVWEFYEP 578 Query: 595 LVGTLYQL 602 +G L Q+ Sbjct: 579 FLGELAQV 586 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 125 bits (314), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 158/610 (25%), Positives = 262/610 (42%), Gaps = 83/610 (13%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L + E P+ A+ I L G+G V GH+ + D + Sbjct: 6 MKLVVVESPAKAKTIEKYL-------------GSGYQVLASYGHIRDLPSKDGSVNPDNG 52 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 +++ WQ P + +L I+ + E+ ++ A DPDREG+ + +L+ L+ Sbjct: 53 FSMV--------WQNYPDKA--HRLKAIEDAVKESDSLILATDPDREGEAISWHILELLK 102 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R N + AV A+ R L + LAR D+L G ++ Sbjct: 103 TKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDN--DLINAYLARRALDYLVGFTLS--- 157 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE-RFTA- 238 IL R G S GRVQ+ L LVV R++EIE F ++++ V+A + AD FT+ Sbjct: 158 PILWRK--LPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADM--EADSIGFTSR 213 Query: 239 --IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 W+ + E+ + + AE + + V++ K S + PF+ S Sbjct: 214 LIQWRGQKL------EKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTST 267 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA--ISVH 354 LQ EAA++ G +A + + + Q LYE LITY R+D + E A + + Sbjct: 268 LQQEAARKLGFAASHTMRLAQSLYE-EGLITYMRTDGVQMDESAIAAARKTITQRYDGGY 326 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 PD Q V +AH AI PT S + + A++Y LI ++ L Sbjct: 327 VPDKPRQYQVKA--------KNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQ 378 Query: 415 CPDAVFRKCVIELDIAKGKFVAK--ARFLAEAGWRTLLGSKERDEENDGTP------LPV 466 A + ++L G+ V + + + +G+ TL D ND LP+ Sbjct: 379 MASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPL 438 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + GD L ++ + TQPP +++A+L+ M +DL G+G + Sbjct: 439 LRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKM---------EDL--------GIGRPS 481 Query: 527 TRAGIIELLFKRGFLT-KKGRYIHSTDAGK---ALFHSLPEMATRPDMTAHWESVLTQIS 582 T A +I++L R ++T ++ R+I S +AG+ A E D TA E L +IS Sbjct: 482 TYASVIQVLKDRAYVTLERNRFIPS-EAGRLLTAFLERFFERYVSYDFTAGLEDSLDEIS 540 Query: 583 EKQCRYQDFM 592 + +Q + Sbjct: 541 GGRADWQKVL 550 >UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=TOP1_AQUAE Length = 540 Score = 125 bits (313), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 166/628 (26%), Positives = 276/628 (43%), Gaps = 114/628 (18%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M LFI E P+ A+ I L G G +V +GH+ + + + Sbjct: 1 MELFIVESPTKAKTIQKFL-------------GKGFLVKATLGHVKDLPEKEL------- 40 Query: 61 WNLADLPIVPEKWQLQ-PRPSVTKQLNVIKRFLHEASEIVHAG-DPDREGQLLVDEVLDY 118 DL + K+ + + + +QL + R S IV+ G DPDREG + + + Sbjct: 41 --GVDLRTLKAKYVYKRGKKKLVEQLKKLSR----RSSIVYLGTDPDREG----EAIAYF 90 Query: 119 LQLAPEK-RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ EK + ++R + ++ P+A+ +I + + L + AR D L G ++ Sbjct: 91 LKKDLEKVNKNIKRAVFYEITPEAIRESIRN--AGDVNMNLVYAQFARRILDRLIGYLIS 148 Query: 178 RAYTILGRN-AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 IL + Y+ LS GRVQ+P L L+V R+ EI+NF K ++ VKA ++ E F Sbjct: 149 ---PILWKEFKNYK--LSAGRVQSPALRLIVEREREIQNFKVKKYYYVKA-LLRKGSEEF 202 Query: 237 TAIW-----QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 AI+ PS+A +++ + L + + V K+E S P P Sbjct: 203 WAIYDYRYENPSDA---------KIIAKKLEKGYFS--------VYKVEKKKEKVSPPKP 245 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F S LQ EA +FG S++ + Q+LYE ITYPR+D + E+ MN I Sbjct: 246 FITSDLQSEANAKFGFSSERTQKLAQELYEKG-YITYPRTDSYRMNEKK---AKEFMNYI 301 Query: 352 -SVHAPDLLPQPVVDPDIRNRCWDDKKV--DAHHAIIPTARSSAINLTENEAKVYNLIAR 408 + + + R R + +K AH I PT+ I E +Y+LI R Sbjct: 302 EKKYGKEYVG--------RLRRFREKATAQGAHECIRPTSLREEIPEREELRLLYDLIFR 353 Query: 409 QYLMQFCPDAVF--RKCVIELDIAKGK----FVAKARFLAEAGWRTLLGSKERDEENDGT 462 + + + + K +E + K VAK + GW + S+ +E+ Sbjct: 354 RTIASLMKEMLLEREKVTVEAITPELKHPVYLVAKGLKIVFDGWSRVYPSEITEEK---- 409 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + +GD L K + ER+TQPP +T+ TL+ K L+K+ G+ Sbjct: 410 -LPELYEGDLLDLVKTTLEERKTQPPPRYTEGTLI------------KTLEKL-----GI 451 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPD--MTAHWESVLT 579 G +T A I++ L +RG++ K + + T+ + L E T D TA E L Sbjct: 452 GRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTLMDYKFTAQMEEKLD 511 Query: 580 QISEKQCRYQ----DFMQPLVGTLYQLI 603 + E + ++ +FM+ + G +++ Sbjct: 512 LVEEGKLNWKSVVYEFMEKIFGKELEMV 539 >UniRef50_UPI00006CAF66 DNA topoisomerase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CAF66 Length = 1386 Score = 124 bits (312), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 153/653 (23%), Positives = 269/653 (41%), Gaps = 112/653 (17%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIE----CGNGQVVTW---------------CIG 43 L +AEKPS+AR+IA+ L G GF C V T+ IG Sbjct: 245 LMVAEKPSIARSIAEALG-----GAGFTTRKGICKFSNVFTFYGHIFGKKALIKVTSVIG 299 Query: 44 HLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN----VIKRFLHEA---S 96 H+ + Y W D ++L ++ K+ N +I+ EA S Sbjct: 300 HIY----TSDFTQEYQDWRRVD------PYKLFNATTLKKETNPNSQIIQHLQKEAMGAS 349 Query: 97 EIVHAGDPDREGQLLVDEVLDYL--QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE 154 ++ D DREG+ + EVL +L E QQ+ R + + P + +A D L Sbjct: 350 YLILWLDNDREGENICFEVLTICKPELIKEDFQQIFRAKFSSITPIDIRKAFDELSIGPN 409 Query: 155 FVPLCVSALARARADWLYGINMTRA---YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDE 211 F + AR D G+ +R Y + ++ G QTP L V+RD+ Sbjct: 410 FNE-SQAVDARQIIDLKVGVAFSRFQTRYLVRKYEDLNNKKITFGPCQTPTLSFCVQRDD 468 Query: 212 EIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG 271 EI++F++K F+ + I +E W Y +E + + L E + G Sbjct: 469 EIKDFISKPFYRIIPKISLVPNELINLEWTKERT---YDQQEALDVKQEL-ESI-----G 519 Query: 272 QPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRS 331 Q ++V ++K + P+ + A+K++GL QN + + +KLY ITYPR+ Sbjct: 520 QTSVV-KVDNKETQKIKPVALNTVNFLKMASKQYGLGPQNAMQVAEKLY-LGGFITYPRT 577 Query: 332 DCRYLPEE-------HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAI 384 + P++ H ++ IS++A L + + K V H I Sbjct: 578 ESTKYPDKFDFNSVLHAVCQYHQNQNISIYAQKLQQNGIHKSRL------GKDVGDHPPI 631 Query: 385 IPTARSSAINLTENEAKVYNLIARQYLMQFCPDA-VFRKCV---IELDIAKGKFVAKARF 440 PT + L+ +E +Y L+ R +L D +++K V ++ + K K F Sbjct: 632 TPTNKIMRQQLSRDEQNIYELVCRHFLATVSSDCRLYKKKVNFYCKIYFYQTKKNNKVLF 691 Query: 441 LAEAGWRTLLGSKERDE------------ENDGTPLPVVAKGDELLCEKGEVVERQTQPP 488 +L+G+ D+ EN+ +P ++GD++ ++ +TQPP Sbjct: 692 QTGNQTFSLIGTAVIDKGYLEALPWQKIYENE---IPNFSEGDQIYLHSVDIHSGKTQPP 748 Query: 489 RHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKG--R 546 H T++ L+S M +G+GT+A+ A I+ + R ++ G R Sbjct: 749 DHLTESDLISLM-----------------EQNGIGTDASMAQHIQNICDREYVQVVGQAR 791 Query: 547 YIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + T+ G +L H+ E+ P++ + E + IS+ + +Q ++ Sbjct: 792 RLVPTELGSSLIHAYAEIDPELVAPNLRSSIERSVDLISQGELDKDQVLQSVI 844 >UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteobacteria RepID=TOP1P_XYLFA Length = 660 Score = 124 bits (311), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 147/605 (24%), Positives = 258/605 (42%), Gaps = 85/605 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I E P ++ +L G+G + +GH+ + Q + + Sbjct: 1 MKLMIIESPGKIEKLSTIL-------------GDGWKIAASVGHVRDLPQKEMGVA---- 43 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 P ++L R + +K L +A + A DPDREG+ + + L+ Sbjct: 44 -----APDFKPSYELTERGEGV--VAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLK 96 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 L+ R N++ AV+ ++ R+ V + AR D L G ++ Sbjct: 97 LS-----NPLRVTFNEITANAVKASLVAPRTID--VKRVAAQEARRVLDRLVGYMVSPE- 148 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 L R G + LS GRVQ+P + LVV R+ EI+ F + F ++ AD + + W Sbjct: 149 --LSRLTGKR--LSAGRVQSPAVRLVVEREREIKAFKVTNHF---GAMLFFADAKTSGEW 201 Query: 241 QPSEACEP--YQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +P ++ + R A V + +V S+++ S P PF+ S +Q Sbjct: 202 SAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKA---VVVKSFDESEAKRSPPPPFTTSTMQ 258 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A+ G+ + +D QKLYE ITY R+D + +E +AV + + D+ Sbjct: 259 QAASVTLGVDPKAAMDAAQKLYEQGH-ITYHRTDNPNVSDESLGDIYAVSVKLGL---DI 314 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPD 417 +P R H A+ PT T ++ +Y LI + + D Sbjct: 315 AEKP------RKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLRAIACQLAD 368 Query: 418 AVFRKCVIELDIAK---GK---FVAKARFLAEAGWRTLLGSKERDEEN-----DGTPLPV 466 A + + L+ A+ GK F A+ R L GW L+ + +EE+ P+PV Sbjct: 369 ARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPV 428 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 A G+ L +G+++E++T+PP H+T ATL+ + ++G+G A Sbjct: 429 CAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLE-----------------SEGIGRPA 471 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDM--TAHWESVLTQISEK 584 T A I++ + RG++ + +Y+ T+ G+ + SL D+ T E L +I++ Sbjct: 472 TYAAIMDNIVSRGYVKTEKKYLFPTETGELIVDSLVGKFEFLDLGFTREIEESLDRIAQG 531 Query: 585 QCRYQ 589 + Y+ Sbjct: 532 ESGYK 536 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 124 bits (311), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 135/547 (24%), Positives = 248/547 (45%), Gaps = 81/547 (14%) Query: 94 EASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS 153 +AS + A D DREG+ + + L + PEK ++R N++ A++ A Sbjct: 76 KASTVYLASDLDREGEAIAWHLYKVLDIPPEK---IRRVTFNEITKDAIQEAF------K 126 Query: 154 EFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQ----------GVLSVGRVQTPVL 203 ++ P+ + +N +A IL R GY+ LS GRVQ+ + Sbjct: 127 QYGPINMEK-----------VNAQQARRILDRIVGYKISPLLWKKIAKRLSAGRVQSVAV 175 Query: 204 GLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEAC-EPYQDEEGRLLHRPLA 262 L+V R++EI F +++++ A + T + ++ + +P +A + +D+ + + A Sbjct: 176 RLIVEREKEINEFKPHEYWKITAELKTISGDKKSDDIKPFKALLQKLEDKNIEIKNEQQA 235 Query: 263 EHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET 322 + + ++ I+T+ + + +AP PF+ S LQ +A+ R SA+ + I Q+LYE Sbjct: 236 KEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQQQASTRLQFSAKKTMLIAQQLYEG 295 Query: 323 --------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWD 374 LITY R+D ++ + + S + D LP+ P+I Sbjct: 296 IDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIE--SNYGKDYLPE---KPNIYA---S 347 Query: 375 DKK--VDAHHAIIP-----TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL 427 +KK AH A+ P T S LT+++ K+Y LI ++++ A++ +E+ Sbjct: 348 NKKGTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWKRFVASQMKPALYAITDVEI 407 Query: 428 DIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQP 487 + F + R L G TL+ E D E LP + K L + + TQP Sbjct: 408 TSNRYIFKTRGRELLFDG-HTLISGHEVDREEQ--ILPPLEKDHVLELIQLLPTQHFTQP 464 Query: 488 PRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY 547 P +++A+L+ K L+K+ G+G +T A II + RG++ ++ R Sbjct: 465 PPRYSEASLV------------KTLEKM-----GIGRPSTYATIISTIQDRGYVKQEKRA 507 Query: 548 IHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRY----QDFMQPLVGTLY 600 ++T+ G + L E + + T+H E L +I EK+ + ++F +P L Sbjct: 508 FYATELGILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKKIDWLTVLKEFYEPFKIDLE 567 Query: 601 QLIDQAK 607 + I + K Sbjct: 568 KAIGEMK 574 >UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1X1Z5_CYAA5 Length = 719 Score = 124 bits (310), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 148/570 (25%), Positives = 238/570 (41%), Gaps = 88/570 (15%) Query: 81 VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQ 140 V +QL + + + + I A DPDREG+ + + + + QR + ++++ + Sbjct: 84 VIRQLQMTAKRTN-SERIFIATDPDREGECIGWHAAQVMGI-----KNPQRIVYSEISEK 137 Query: 141 AVERAIDRLRSNSEFVP--LCVSALARARADWLYGINMTRAYTILGRNAGY-QGVLSVGR 197 AV RAI +N F+ L SAL R+ D L G YT Y +G S+GR Sbjct: 138 AVRRAI----ANPRFLDTNLVASALGRSTLDKLIG------YTGSPLLWDYVEGAKSMGR 187 Query: 198 VQTPVLGLVVRRDEEIENFVAKDFFEV--------KAHIVTPADERFTAIWQP---SEAC 246 VQTPVL L+ R+E I+NF + ++ V KA +++ + S+ Sbjct: 188 VQTPVLTLICEREETIQNFKPETYYSVWSLYKEGLKAFYAGESNDNSEDSEEERDDSQTP 247 Query: 247 EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFG 306 + Q E R+ A +V V S K+ +S P PF+ S LQ A R Sbjct: 248 KETQKESLRVTSEAEANRLVAIARNNSHNVVSLETKKSKKSPPAPFTTSNLQQAAGARLK 307 Query: 307 LSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDP 366 S + + QKLYE +ITY R+D + + + + + P+ LP+ V Sbjct: 308 FSPDQTMKLAQKLYEAG-VITYHRTDSTVISGDFC---KVIRQYLKANDPENLPKSV--- 360 Query: 367 DIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFR 421 I++R + + +AH AI P T A L + K+Y LI + + C A Sbjct: 361 -IKHRQSKNAQ-EAHEAIRPVDLAKTETDIASELGDAAGKLYQLIWFRTVASQCKPAELD 418 Query: 422 KCVIELDIAKGKFVAKARFLAEAG----WRTLLGSKERDEENDGTPLPVVAKGDELLCEK 477 K I + AK + + AG WR L E LP V + E Sbjct: 419 KTTITTQSDTVFWKAKGQVVTFAGYLRYWRDLGADSE---------LPSVENHQVVTLED 469 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 + ++QT+PP FT+A ++ +R G+G +T + I+ L Sbjct: 470 AQAEKKQTKPPSRFTEAQMVK-----------------VREKKGIGRPSTFSPTIQTLKD 512 Query: 538 RGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQ----- 589 R ++ + R + T G ++H + E T + TA ES L I++ ++Q Sbjct: 513 RNYVAVEKRMLKPTQVGLKVYHFVREHLTELGTVEFTAQMESHLDAIAKGDEKWQPYVCQ 572 Query: 590 ---DFMQPLVGTLYQLIDQAKRTPVRQFRG 616 D QP TL ++ + V+ F G Sbjct: 573 FHFDHWQP---TLIKIAQTLGKPAVKSFNG 599 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 123 bits (309), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 130/503 (25%), Positives = 234/503 (46%), Gaps = 65/503 (12%) Query: 72 KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQ--V 129 K+Q+ R + K ++ I + +A E++ A DPDREG+ + + + L+ EK+ + + Sbjct: 51 KYQIIERNA--KHVDAIVKAAKKADEVLLATDPDREGEAISWHISEILK---EKKVKTPM 105 Query: 130 QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARA-DWLYGINMTRAYTILGRNAG 188 +R ++ A++ D +R+ E V A RA D+L G N++ +L + Sbjct: 106 KRVAFYEITESAIQ---DAVRNPREIASDLVDAQQARRALDYLVGFNLS---PLLWKK-- 157 Query: 189 YQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-PADERFTAIWQ--PSEA 245 LS GRVQ+P L ++V R+EEIE FVA++++ + H+ + + FTA E Sbjct: 158 ISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTL--HLDSHKGSQAFTAKLTHFKGEK 215 Query: 246 CEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRF 305 + + E H ++ + + + A V KR + + PF+ S LQ ++ Sbjct: 216 LDQFAVE-----HEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVRQL 270 Query: 306 GLSAQNVLDICQKLYETHK-------LITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 G++ V+ Q+LYE LITY R+D L +E + A D Sbjct: 271 GMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGA--NFDKDY 328 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTA---RSSAIN--LTENEAKVYNLIARQYLMQ 413 LP V + + +AH A+ PT+ A+ LT+++A++Y L+ ++ + Sbjct: 329 LPPHAVQYKAKTK----NAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVAC 384 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVVAKGDE 472 A F ++ + +G F A + LA AG+ L + DE+++G + LP + +G+ Sbjct: 385 QMTAAQFDTVAADITVGEGTFRATGQTLAFAGF---LAVYQDDEDDEGESKLPALVEGET 441 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L ++ + TQPP +T+A+L+ A+ G+G +T A II Sbjct: 442 LPVDRLYGEQHFTQPPPRYTEASLVKALEEY-----------------GIGRPSTYASII 484 Query: 533 ELLFKRGFLTKKGRYIHSTDAGK 555 L R ++ + + TD G+ Sbjct: 485 STLQDREYVVLEKKRFQPTDVGR 507 >UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LVP1_ARATH Length = 926 Score = 123 bits (309), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 170/624 (27%), Positives = 270/624 (43%), Gaps = 97/624 (15%) Query: 3 LFIAEKPSLARAIADVLPK-PHRKGDG---------FIECGNGQ----VVTWCIGHLLEQ 48 L +AEKPS+A+++A +L + R +G F NGQ ++T IGHL+E Sbjct: 12 LNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMEL 71 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASE----IVHAGDP 104 D RY +W+ D + + ++ P K IK+ L E + +V D Sbjct: 72 EFAD----RYRKWHSCDPADLYQAPVMKHVPEDKKD---IKKTLEEEARKSDWLVLWLDC 124 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREG+ + EV+D + A + ++R + L + + A+ LR ++ V A Sbjct: 125 DREGENIAFEVVDVCR-AVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDA-- 181 Query: 165 RARADWLYGINMTRAYTILGRN------AGYQG--VLSVGRVQTPVLGLVVRRDEEIENF 216 R D G + TR T+L R+ G + V+S G Q P LG +V R EI+ Sbjct: 182 RQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAH 241 Query: 217 VAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AI 275 ++F+ + Q E + G L A + +P A Sbjct: 242 EPEEFWTINCS------------HQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTAT 289 Query: 276 VTSYNDKRESESAPLPFSLSALQIE--AAKRFGLSAQNVLDICQKLYETHKLITYPRS-- 331 V + RE P P+ L+ +++E A++ F LS+++ + + ++LY+ I+YPR+ Sbjct: 290 VMNVPHPRERFKYP-PYPLNTIELEKRASRYFRLSSEHTMKVAEELYQA-GFISYPRTET 347 Query: 332 -------DCRYLPEEHFAGRHAVMNAISVHAPDLL-PQPVVDPDIRNRCWDDKKVDAHHA 383 D R + EE RH A +A LL P+ + + N DDK AH Sbjct: 348 DSFSSRTDLRAMVEEQ--TRHP---AWGSYAQRLLEPEGGLWRNPANGGHDDK---AHPP 399 Query: 384 IIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLA 442 I PT SS N + + VY L+ R YL AV + +E+DIA +F A R + Sbjct: 400 IHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAIL 459 Query: 443 EAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + + R E G+ +PV KG + + + T+PP +A LLS M Sbjct: 460 AKNYLEVY----RFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCM-- 513 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHS-TDAGKALFHSL 561 DK G+GT+AT I+ L RG+ TK S T+ G+AL Sbjct: 514 ------DK---------AGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGY 558 Query: 562 PEMAT---RPDMTAHWESVLTQIS 582 +M +P++ A E + ++S Sbjct: 559 DDMGYELWKPNLRALMEHDMNEVS 582 >UniRef50_B7G3B1 DNA topoisomerase n=2 Tax=Bacillariophyta RepID=B7G3B1_PHATR Length = 1009 Score = 122 bits (306), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 162/666 (24%), Positives = 283/666 (42%), Gaps = 94/666 (14%) Query: 3 LFIAEKPSLARAIADVLPK-PH-------RKGDGFIE----C-------GNG-------- 35 L +AEKPS+ARA+A V + P+ R+G+ C GNG Sbjct: 45 LNVAEKPSVARALASVFARLPNAVDRGMRREGNQVFSHENVCFPSVFSQGNGVCVQGPST 104 Query: 36 -------QVVTWCIGHLLEQAQPDAYDSRYARWNLAD-LPIVPEKWQLQPRPSVTKQLNV 87 + T GHL Q P AY W+ D + + + R + + Sbjct: 105 SQRAALYMITTSVRGHLASQDFPPAYG-----WSKCDPIALFEAPIETSYRDDMQPLERM 159 Query: 88 IKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAID 147 +K +A ++ D DREG+ + DEV L R QV R + + P +ERA+ Sbjct: 160 LKSLSRQAQVLILWLDCDREGEAIGDEVRTVC-LGSNSRLQVYRARFSTVLPVEIERALQ 218 Query: 148 RLRSNSEFVPLCVSALARARADWLYGINMTRAYTI-LGRNA-GY--QGVLSVGRVQTPVL 203 L +E+ + + AR+ D G TR T+ L R G+ QGV+S G Q P L Sbjct: 219 TLGRVNEY--MVAAVQARSTLDLRVGAAFTRFQTLRLQRKFDGFAEQGVISYGPCQFPTL 276 Query: 204 GLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRP--- 260 G VV R IE F+ +DF+ ++ I + D + ++ + ++ R +H Sbjct: 277 GFVVERWARIETFIPEDFWHLELAI-SVDDTYHQQSQEEDQSAARGRTQQNRTIHFSWKR 335 Query: 261 --LAEHVVNRI------SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNV 312 L + ++ + A+VT+ N + ++ P+P + LQ A+ + ++ + Sbjct: 336 GYLYDKLLTTVLFEECLEAGEAVVTAMNGRTRNKWRPVPLATVELQKRASMYLRIGSETL 395 Query: 313 LDICQKLYETHKLITYPRSDC-RYLPE-EH---FAGRHAVMNAISVHAPDLLPQPVVDPD 367 + ++LY+ I+YPR++ R+ PE EH ++ +A LL + Sbjct: 396 MSAAEELYQ-QGYISYPRTETERFRPEFEHRPLIQQFSSLQGEFGAYASKLLNENGFQIP 454 Query: 368 IRNRCWDDKKVDAHHAIIPTARSSAINLTENEA--KVYNLIARQYLMQFCPDAVFRKCVI 425 + DD+ AH I P A++ N +++ K+Y+LI + YL DAV R + Sbjct: 455 RAGKS-DDQ---AHPPITP-AKAVDPNTIQDQIQRKIYSLIVKHYLACCSRDAVGRGTTL 509 Query: 426 ELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQT 485 + + +F A + E W + ER G LP + G + + E ++ Sbjct: 510 TVRMGTEEFNATGLMVIEKNWLEIYSPWERWGSGQGE-LPPLQVGSRIRPTSFLMKEGRS 568 Query: 486 QPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKG 545 PP+ ++ L+S M D+ +G+GT+AT A I + R + K G Sbjct: 569 GPPQPISEVELISLM--------DR---------NGIGTDATIAQHISTILDREYARKDG 611 Query: 546 RY-IHSTDAGKAL---FHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQ 601 R T G AL ++S+ +PD+ E+ +++ + ++ M P++ + Sbjct: 612 RQKFLPTPLGIALVEGYNSMGYQLNKPDLRREMEAECNEVASGRKTKEEIMVPILAKMKS 671 Query: 602 LIDQAK 607 + A+ Sbjct: 672 CYETAR 677 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 122 bits (305), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 156/628 (24%), Positives = 268/628 (42%), Gaps = 93/628 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G G V GH+ +A P S N Sbjct: 5 LVIVESPAKAKTIEKFL-------------GPGYKVLASYGHV--RALPSKQGSVDVEHN 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + L V P K + ++K+ ++ E++ A DPDREG+ + +L+ L + Sbjct: 50 FSPLYHV--------LPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGID 101 Query: 123 PE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K +V+R +++ A++ AI + + L + AR+ D+L G N++ Sbjct: 102 ENAKSPEVKRVTFHEITKGAIQEAISKPGHIAR--ELVDAQQARSILDYLVGFNLS---P 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 L + Y LS GRVQ+ L L+ R++EI+ F A++++ ++ + T F A Sbjct: 157 FLWKKIRYG--LSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLY 214 Query: 242 PSEACEPYQDEEGR--LLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + G+ + A +V I + V + + PF+ S LQ Sbjct: 215 AVDG-----NSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQ 269 Query: 300 EAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G SA+ + + QKLYE LITY R+D L A A Sbjct: 270 EASRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVAL--SQVATGEARELITR 327 Query: 353 VHAPDL-LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-----AINLTENEAKVYNLI 406 ++ D L +P V +N+ + + +AH A+ PT+ S+ +L+ ++ K+Y LI Sbjct: 328 MYGEDYALDKPRV---FKNKAKNAQ--EAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLI 382 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGK---FVAKARFLAEAGWRTL-LGSKERDEEND-- 460 ++ + A + DI G+ F A + + G+ L + ++DE+ D Sbjct: 383 WQRTVASQMATAQLEATTV--DIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQ 440 Query: 461 --GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 GT LP + + L C++ + + TQPP FT+A+L+ + Sbjct: 441 EEGT-LPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTL-----------------E 482 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWE 575 G+G +T A II L R ++ + R ++ D G + L + D TA E Sbjct: 483 EHGIGRPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLE 542 Query: 576 SVLTQISEKQCRYQ----DFMQPLVGTL 599 L IS + +Q DF +P + L Sbjct: 543 EDLDAISRGEREWQPVLKDFWEPFISRL 570 >UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q3M6J7_ANAVT Length = 728 Score = 122 bits (305), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 141/544 (25%), Positives = 231/544 (42%), Gaps = 76/544 (13%) Query: 77 PRPSVTKQ-LNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLIN 135 PR +K+ + +K + SE+V A DPDREG+ + + + L L ++ +R + Sbjct: 60 PRDQRSKETIQQLKSAAKQVSEVVLATDPDREGETIAWHLKEVLGL-----REPKRVVYT 114 Query: 136 DLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSV 195 ++ AV+ AI R + L + L R D L G + L G SV Sbjct: 115 EITASAVQSAIAHPRKLD--LNLVGAGLCRDCLDKLVGYKGSPLVWALN-----NGAKSV 167 Query: 196 GRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ---------PSEAC 246 GRVQ+ L L+ +R+ EI++FV +D++ V V E F A ++ P Sbjct: 168 GRVQSSTLHLICQREREIQSFVPQDYWSVWVDYV----EGFRAFYKGAVNTRSDSPETEV 223 Query: 247 EPYQDEEGRLLHRP-----LAEHVVNRISGQ----PAIVTSYNDKRESESAPLPFSLSAL 297 E + D G P LAE NR+ + P + Y K + P PF S L Sbjct: 224 EIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQPPPPFITSTL 283 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q A + + + + + QKLYE LITY R+D L E + + + P Sbjct: 284 QQAAGSKLKFAPEKTMQLAQKLYEA-GLITYMRTDSVMLSPEFC---ESARQWLEQNDPQ 339 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA--RSSA---INLTENEAKVYNLIARQYLM 412 +P+ V R+R H AI PT R SA I L+ +E +Y +I ++ + Sbjct: 340 NVPKQVA----RHRS-SKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIA 394 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 C A RK V+ + + A+ + + G+ + +D T LP + +G Sbjct: 395 SQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSKD-----TLLPTLQQGQM 449 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + E ++QTQPP +++ L+ M G+G +T + I Sbjct: 450 VTLENAGHEKKQTQPPPRYSEPKLVQLM-----------------ERKGIGRPSTYSPTI 492 Query: 533 ELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 L KRG++ +H T+ G L +LP++ + TA E+ L I+E + + Sbjct: 493 ATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDL-LEAEFTAKMENALDAIAEGKQPW 551 Query: 589 QDFM 592 Q ++ Sbjct: 552 QIYL 555 >UniRef50_C6A350 DNA topoisomerase I n=3 Tax=Euryarchaeota RepID=C6A350_THESM Length = 1228 Score = 122 bits (305), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 101/329 (30%), Positives = 154/329 (46%), Gaps = 30/329 (9%) Query: 3 LFIAEKPSLARAIADVLP--KPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPDAY 54 L IAEKP++A+ IA L KP RK G G +V +GHL A + Sbjct: 4 LIIAEKPNVAKKIAYALAERKPIRKTIGKVPYYELTRDGKKIIVAPAVGHLFSLAPKE-- 61 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 R + + D+ VP + + + +K +A E V A D D EG+++ Sbjct: 62 --RTYGYPVFDIDWVPVYLAEKGKSYTKDYIKALKELAKQADEFVIACDYDTEGEVIGYT 119 Query: 115 VLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 L Y + P K +R + L Q + RA L F + + + R DW +G Sbjct: 120 ALKYACGVEPSK---AKRMKFSALTKQDLLRAWYNLEPTINF-GMADAGITRHILDWYWG 175 Query: 174 INMTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 +N++RA + + +++G VLS GRVQ P L +V R++EIENFV ++ +K I+ Sbjct: 176 VNLSRALSSAIRKSSGKWHVLSTGRVQGPTLKFLVDREKEIENFVPTPYWVIKM-ILEKN 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 E++TA + E+ R+L+ A+ +V PA V ++ S P PF Sbjct: 235 GEQYTANY-----------EKDRILNEEEAKRIVEEAKKGPAFVEKIEITQQKRSPPYPF 283 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYE 321 L LQ E+ FG S + L+I QKLYE Sbjct: 284 DLGTLQRESYSAFGYSPKKTLEIAQKLYE 312 Score = 73.2 bits (178), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 78/328 (23%), Positives = 153/328 (46%), Gaps = 54/328 (16%) Query: 305 FGLSAQNVLDICQKLYET-----HKLI---------TYPRSDCRYLPEEHFAGRHAVMNA 350 G+ + C K+Y+ H I +YPR+ + LP+ + R + N Sbjct: 792 LGIKSIEKFHYCGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPK-NLNFRSIIQNL 850 Query: 351 ISV-----HAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARS-SAINLTENEAKVY 403 + HA +LL + ++ P + KK D AH AI PT +L ++E +Y Sbjct: 851 AKIPEYKPHAHELLGKGILKPV------EGKKDDPAHPAIYPTGEVPKPGDLNKDEQNLY 904 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +LI R++L F A+ I ++ K F+ + GW + G + +E Sbjct: 905 DLIVRRFLAAFAEPAIRESMKIIINSNKHHFILNGSRTIKEGWLKIYGKYVKFDE---VI 961 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP KG+++ + + +++T+PP ++ A+++ M +DL G+G Sbjct: 962 LPKFEKGEKVNVIQIKKEKKKTKPPARYSPASIIKKM---------EDL--------GIG 1004 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDMTAHWESVLT 579 T+ATRA I+E L+ RG++ K + I T G +AL +++P++ + ++T +E + Sbjct: 1005 TKATRAQILETLYSRGYIEGKKK-IKVTPLGIKVIEALENNVPDIIS-VELTREFEQKME 1062 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAK 607 +I ++ + + ++ L +++ + K Sbjct: 1063 EIMARKLKKERVIEESKTALIKVLKEFK 1090 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 121 bits (304), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 144/546 (26%), Positives = 235/546 (43%), Gaps = 70/546 (12%) Query: 83 KQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLIND---LNP 139 K + +K ++ +A ++ A DPDREG+ + + L + PE +V+ I LN Sbjct: 61 KVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNS 120 Query: 140 QAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQ 199 R ID R N++ AR D L G ++ +L R + LS GRVQ Sbjct: 121 LKSPRPIDLNRVNAQ--------QARRVLDRLVGYGLS---PLLWRKV--KRGLSAGRVQ 167 Query: 200 TPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHR 259 + L LVV R+EEIE F ++++++ ++TP +ER A +G+ Sbjct: 168 SVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLAR---------LARFKGKKFTC 218 Query: 260 PLAEHV--VNRISGQPAIVTSYNDKRE-SESAPLPFSLSALQIEAAKRFGLSAQNVLDIC 316 AE V V + A + ++E S++ PLPF+ S + EA +R G+ + + + Sbjct: 219 RTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVA 278 Query: 317 QKLYETHK--------LITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDI 368 Q+LYE LITY R+D + EE A A + + V D Sbjct: 279 QQLYEGVDLGPEGPVGLITYIRTDSTRVSEE------AKERAWAFIKEHYGAEFVGDVPP 332 Query: 369 RNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKC 423 + R + DAH AI P T LT ++ K+Y LI ++L A + Sbjct: 333 KERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLT 392 Query: 424 VIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVER 483 E+++ F A R L G+ L +E +EE LP + +G+ L ++ + Sbjct: 393 RAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGK---LPPLREGEVLTFQEFVPQQH 449 Query: 484 QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTK 543 T PP +T+ TL+ A+ G+G +T A IE + KRG++ + Sbjct: 450 FTTPPPRYTEGTLVKAL-----------------EEKGVGRPSTYAPTIETILKRGYVVR 492 Query: 544 KGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 +Y+H T G+ + L E TA E L + E Q + D ++ + Sbjct: 493 VDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFS 552 Query: 601 QLIDQA 606 Q + +A Sbjct: 553 QDLVRA 558 >UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y06_METBU Length = 780 Score = 121 bits (304), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 136/544 (25%), Positives = 230/544 (42%), Gaps = 66/544 (12%) Query: 83 KQLN------VIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLIND 136 KQ+N I + A +V A D DREG+ + E + + V+R + Sbjct: 81 KQINKASFGSAILKISKGADLLVLACDFDREGENIGFEAKSIAEKVSD--ATVKRARFSS 138 Query: 137 LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRN-AGYQGVLSV 195 L+ +E+A + L E + +SA AR D G + TR T+ R A +GVLS+ Sbjct: 139 LSKSEIEKAFNDLVEPDE--NMAMSAEARQILDLKMGASFTRFVTLSVRERARTKGVLSI 196 Query: 196 GRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGR 255 G QTP G V R+ I F ++DF++++ + T + + G Sbjct: 197 GPCQTPTCGFVYERELAIRKFDSRDFWKIEG-VFTGKGADIIGVHRG-----------GH 244 Query: 256 LLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLD 314 + + A + ++ G + A+++ K + + P P + + A+K G+S L+ Sbjct: 245 IYDKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLKRASKYLGVSPDQALE 304 Query: 315 ICQKLYETHKLITYPRSDCR-YLPEEHFAG--RHAVMNAISVHAPDLLPQPVVDPDIRNR 371 I ++LY + +YPR++ Y + FA + A LL Q + P RN Sbjct: 305 IAEQLYLSG-FTSYPRTETNMYADDMDFASILKGFTKGDYQDFALLLLSQKAIVP--RN- 360 Query: 372 CWDDKKVDAH-HAIIPTARSSAINLTENEAK------VYNLIARQYLMQFCPDAVFRKCV 424 K D H H I ++ + E K VY+LI R ++ P AVF K Sbjct: 361 ----GKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPPAVFEKTR 416 Query: 425 IELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQ 484 E+ + F + AGW + E+ LP + G+ L +K ++ Q Sbjct: 417 FEITMEDELFDSTGSIQKNAGWLAVYPF----EKPQDKILPALDLGEVLDVKKITNIKSQ 472 Query: 485 TQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKK 544 T PP+ T+A LL+ M DK G+GT+AT IE KRG+ K Sbjct: 473 TTPPKRLTEAELLTLM--------DK---------HGIGTKATAPSHIETNKKRGYFEVK 515 Query: 545 GRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQ 601 G+ I D G L +L + +PD+ + ES++ + + +++ ++ + + Sbjct: 516 GKTIAILDTGFTLMDALNSSVPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKE 575 Query: 602 LIDQ 605 + Q Sbjct: 576 MYSQ 579 >UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanosomatidae RepID=A4I3Q5_LEIIN Length = 867 Score = 121 bits (303), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 143/622 (22%), Positives = 250/622 (40%), Gaps = 84/622 (13%) Query: 3 LFIAEKPSLARAIADVLPKP-----------HRKGDGFIECGNGQVVTWCIGHLLEQAQP 51 L +AEKPSLA +IA +L + F+ VT GH+ Sbjct: 6 LMVAEKPSLAESIATILSNGSCSRRTRALPVYEYTGNFMGSPAYFKVTSTTGHVFSCD-- 63 Query: 52 DAYDSRYARWNLAD---LPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS---EIVHAGDPD 105 + S++ W+ D L P W+ V HE+ +V D D Sbjct: 64 --FTSQHQNWDRTDEEQLFTAPITWK-------DTSGKVSHHLEHESQGCDTLVLWLDCD 114 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 REG+ + EV+ ++ + R + + + + A L ++ + V+ R Sbjct: 115 REGENICFEVMQVVRREIYNHHSIFRAHFSAITAEEIFHAFRNLGKPNKNISDAVTC--R 172 Query: 166 ARADWLYGINMTRAYT--ILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFF 222 D G+ TR T G+ V+S G QTP LG V+R +EI NF ++F+ Sbjct: 173 QELDLKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFW 232 Query: 223 EVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 + P R A+ Q ++ + GRL +A ++ RI+ + T N Sbjct: 233 R-----LVPVASRGGALLQ-------FEWDRGRLFDETMARLILQRITKSGKVATVVNVS 280 Query: 283 RESESAPLPFSLSALQIE--AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCR-YLPEE 339 +++ P P L+ + + A++ G+ V+ I + LY I+YPR++ Y P Sbjct: 281 VSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAENLY-IRGYISYPRTESTAYPPSF 339 Query: 340 HFAGRHAVMNAISV---HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT 396 + AG A S+ + LL Q P K H I P +S L+ Sbjct: 340 NLAGALAQQKNHSMWGAYVTALLQQGHARPKA------GKDAGDHPPITPMRSASPSELS 393 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 +E +++ I R ++ PD K I +++ F + + + G+ ++ Sbjct: 394 GDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIM--PHAR 451 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 E+D P V KGD + QTQPP + T++ L+ M Sbjct: 452 VEDDRMPTG-VHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLM---------------- 494 Query: 517 RATDGLGTEATRAGIIELLFKRGFLT-KKGRYIHSTDAGKALFHSL----PEMATRPDMT 571 +G+GT+A+ + + + +RG+ + + GR + + G L H + PE+ P + Sbjct: 495 -EKNGIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVL-PLVR 552 Query: 572 AHWESVLTQISEKQCRYQDFMQ 593 + E +T I+E + + D + Sbjct: 553 SRVEEYVTHIAEGRAQLDDVLS 574 >UniRef50_UPI0001C42CB1 DNA topoisomerase III n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C42CB1 Length = 288 Score = 120 bits (300), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 80/302 (26%), Positives = 150/302 (49%), Gaps = 24/302 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIE-----CGNGQVVTWCIGHLLEQAQPDAYD 55 M +AEKPS A+A A L R+G ++ G ++ +GH+LE +P + Sbjct: 1 MYAILAEKPSAAKAYAQAL-NGKRQGRIYVAPPSSLLPEGALICAAVGHILEFLEPGELN 59 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKR--FLHEASEIVHAGDPDREGQLLVD 113 +Y ++L LPI+ + +Q + + L IK F I+ A D EG+ + Sbjct: 60 EKYKSYSLDSLPIIIDLFQYKVVSDKKEVLQRIKDTIFDKRVKTIILATDAAAEGEYIGR 119 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 +L LQ ++ ++R + + ++++A +L++++E +PL A ARA +D++ G Sbjct: 120 NILYRLQC----KKTIKRLWTSSMTATSIQKAFSQLKADAETLPLYYQAKARAESDYMIG 175 Query: 174 INMTRAYTILGRNAG---YQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 + ++RAY IL + G + +S+GRVQTP+L +V+R+ IE F A++F+ VKA Sbjct: 176 LTLSRAYGILLKEQGIVPHNTTISLGRVQTPLLAEIVKRERLIEQFTAENFWTVKATFNN 235 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 + + W + ++E R+ AE + + Q + + ++ + PL Sbjct: 236 QGN-VYEGEW--------FHEKENRIFKEEQAEQLCELVRNQSSTIMEMKEEMRTYQPPL 286 Query: 291 PF 292 + Sbjct: 287 LY 288 >UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2V7T0_SULSY Length = 683 Score = 119 bits (299), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 150/621 (24%), Positives = 272/621 (43%), Gaps = 105/621 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ I E P A+ I+ L G FI V +GH + + + Sbjct: 5 KIVIVESPKKAKEISHFL------GKDFI-------VKATVGHFKDLPENEMG------- 44 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 DL K+ ++ + + K L+ IK+ L E SE++ A DPDREG + + + L+ Sbjct: 45 --VDLNTYEPKFVIKSQ-NHKKILSEIKK-LAEKSEVIIATDPDREGYAIGFFMYEELK- 99 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRL----RSNSEFVPLCVSALARARADWLYGINMT 177 +K ++V+R +++ + ++ I ++N L + L R D + G ++ Sbjct: 100 --KKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTN---FGLFNAFLGRRVGDRIVGYTLS 154 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI-----VTPA 232 I R G G SVGRVQ+P + L+V R+ EI+NF ++ + A + V+P Sbjct: 155 ---PIASREIG--GRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPL 209 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLP 291 FTAI+ E ++ ++ AE + I + A + K+ +S P Sbjct: 210 T--FTAIY-----------ENPKIENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPP 256 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F+ S LQ A+ + + + + + Q L+E+ LITY R+D + E+ G ++N Sbjct: 257 FTTSTLQQTASTVYRFAPEKTMMLAQDLFESG-LITYHRTDSVRISEKAIDGIRNLIN-- 313 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDK--KVDAHHAIIPT------ARSSAIN---LTENEA 400 D LP+ + R + K + DAH AI T + I L+E+ Sbjct: 314 KEFGKDYLPEKI-------RVYKSKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHF 366 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 K+ LI + + DA+F + +DI F A L G++ + +E +++ + Sbjct: 367 KLLKLIYERTVASQMADAIFERTSAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEE 426 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP + D L EK + E+ T+PP +T+ L+ + + Sbjct: 427 NQKLPDLKNKDVLTLEKINLEEKFTKPPARYTEGGLVKKLEEL----------------- 469 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPD------MTAHW 574 G+G +T A II+ + +RG++ K+ + T+ FH + + TR + T Sbjct: 470 GIGRPSTYATIIKTIKERGYVVKENGSLRPTENA---FHLIEYLNTRYNWVIDYSFTKKM 526 Query: 575 ESVLTQISEKQCRYQDFMQPL 595 E L ++ E + +++F++ L Sbjct: 527 EDFLDKVEENKKDWKEFVKQL 547 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 119 bits (298), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 139/507 (27%), Positives = 227/507 (44%), Gaps = 86/507 (16%) Query: 79 PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLN 138 PS K ++ IK + ++ A DPDREG+ + +++ L+L +K +++ +++ Sbjct: 59 PSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLVETLKLPKDKFTRIE---FHEIT 115 Query: 139 PQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGV------ 192 P+A++ AI R L + +A IL R GY+ Sbjct: 116 PRAIQEAIRNPRDID-----------------LDKVEAQQARRILDRLVGYELSPLLWEK 158 Query: 193 ----LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEP 248 LS GRVQ+ L L+ R+EEIE FV ++++ +I +++ I+ Sbjct: 159 VRRGLSAGRVQSVALKLICEREEEIEKFVPEEYW----YIYGEFEDKDKIIYG---KLVF 211 Query: 249 YQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLS 308 Y++EE + + A+ ++ ++ + K E ++ PLPF S LQ EA++R G Sbjct: 212 YKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEASRRLGFP 271 Query: 309 AQNVLDICQKLYETHK-------LITYPRSD-CRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + I Q LYE LITY R+D R PE A AV SV + Sbjct: 272 VSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPE---AREEAVTYIESVFGKEY-- 326 Query: 361 QPVVDPDIRNRCWDDKKV---DAHHAIIPTA-----RSSAINLTENEAKVYNLIARQYLM 412 V + + R KK+ DAH AI PT+ LTE++ K+Y LI ++L Sbjct: 327 ---VGKERKER----KKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLA 379 Query: 413 QFCPDAVFRKCVIELDIAKG--KFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 +A++ VIE+DI G FV+K R L AG+ +L KE +EE + + +G Sbjct: 380 SQMANALYD--VIEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQEG 437 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 ++ + TQPP +T+ATL+ + G+G +T A Sbjct: 438 SDIDLINLTPKQFFTQPPPRYTEATLVRTLEKY-----------------GIGRPSTYAT 480 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKAL 557 IIE L +R ++ + + T GK + Sbjct: 481 IIETLKERKYVEVSKKELVPTTLGKVV 507 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 119 bits (298), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 151/614 (24%), Positives = 261/614 (42%), Gaps = 94/614 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I +L G+ V +GHL + Q R + Sbjct: 34 LIIVESPAKAKTIERIL-------------GSDYKVLASMGHLRDLPQ------RTLGVD 74 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 +A+ PE R V + L ++ +++ +I+ A DPDREG+ + + L + Sbjct: 75 VAN-DFKPEYVSSAERADVIENL---QKEANKSKDILLATDPDREGEAISWHLSKLLDVD 130 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P R +++ P A++ A+ L + + AR D L G ++ Sbjct: 131 PRSNA---RIAFHEITPPAIKEAV--LHPEPIDLNRVDAQQARRVLDRLVGYKLS---PW 182 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + Y+G LS GRVQ+ L+ R+EEI F +++ V+ T E F A Sbjct: 183 LWKQI-YRG-LSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLTQ 240 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + +E ++ + A+ VV I QPA +TS ++ A P++ S +Q +A Sbjct: 241 VDG------KEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKPPYTTSTMQQDAV 294 Query: 303 KRFGLSAQNVLDICQKLYETHK--------LITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 R ++ + + Q LYE + LITY R+D + +E + V+ Sbjct: 295 NRLNFGSKKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIE--RVY 352 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP P++ R D + DAH AI PT A + L+ ++ ++Y LI + Sbjct: 353 GKDYLPP---KPNVYARGKDSQ--DAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWNR 407 Query: 410 YLM-QFCP------DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 +L Q P +AV + + L + + G+ L KE+ ++N+ Sbjct: 408 FLASQMAPQISQATNAVLQSGIYTLRATGTQILFD-------GFTVLRTVKEKKQDNEEL 460 Query: 463 P-LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 P LP + KG +L K E + T PP +T+A+L+ + G Sbjct: 461 PILPALHKGHTVLNTKAEGEQHFTAPPPRYTEASLIKTL-----------------EEKG 503 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVL 578 +G +T A I++ + +R ++ K+G+ TD G + L + D TA E+ L Sbjct: 504 IGRPSTYAPILDTIQRRKYVEKEGKQFVPTDIGFKVTDLLKKYFAGIVSVDFTAQLETWL 563 Query: 579 TQISEKQCRYQDFM 592 +I++ + Y+ M Sbjct: 564 DKIADGKATYKKVM 577 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 118 bits (296), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 154/651 (23%), Positives = 278/651 (42%), Gaps = 118/651 (18%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQP-------DAYD 55 L I E P+ A+ I L G G V +GH+ + + + +D Sbjct: 5 LVIVESPAKAKTIQKYL-------------GKGYEVEASLGHIKDLPKKGLGVDIENNFD 51 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 + Y ++P K ++ + +K+ +A I A DPDREG+ + + Sbjct: 52 TEYV--------VIPGKEKVVAK---------LKKLAKDADAIYLAPDPDREGEAIAAHL 94 Query: 116 LDYLQLAPEKRQQVQ------RCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 + L K+++ R N++ +AV+ A + R L + R D Sbjct: 95 AEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDR--NLVDAQQTRRILD 152 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 L G ++ R LS GRVQT L L+V R+ EI+ FV+K+++ + AH+ Sbjct: 153 RLVGFQVSPLLWDKVRRG-----LSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLH 207 Query: 230 TPA----DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 D RFT I E E +EE + +V+++ V S +++ Sbjct: 208 GQKPPDFDARFTGI--DGEKLEVGNEEESK--------KIVDQLDNAEWSVRSVDNRERR 257 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLP 337 +A PF+ S Q +A+++ G+S + + I Q LYE T LITY R+D + Sbjct: 258 RNAAAPFTTSKFQQDASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVS 317 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN--- 394 E ++ + + P LP+ P++ + D + AH AI P++ + + Sbjct: 318 NEALTEVRELIG--TSYGPQFLPE---SPNVYKQKKDAQ--GAHEAIRPSSVAHTPDDLK 370 Query: 395 --LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK---FVAKARFLAEAGW-RT 448 L ++E KVY LI ++++ AVF + +++D + F L G+ + Sbjct: 371 AYLKDDEMKVYKLIWQRFVASQMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKV 430 Query: 449 LLGSKE-RDEENDGT--PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 SKE +DEE+D LP + +G L + + + T+PP + +A+L+ Sbjct: 431 YEESKEGKDEEDDALKHKLPPLVEGQTLTLKAIKPEQHFTEPPPRYNEASLV-------- 482 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTK---KGRYIHSTDAGKALFHSLP 562 K+L++ G+G +T A I+ + RG++ K +G T+ G + L Sbjct: 483 ----KELEE-----QGIGRPSTYAAILSTIQDRGYVQKTPGRGGKFFPTEIGMVVTDLL- 532 Query: 563 EMATRPDM-----TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 +A D+ T+ E L ++ + Q ++ D ++ +D A++ Sbjct: 533 -VANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYDKFETNLDYAQK 582 >UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B7I2H2_ACIB5 Length = 672 Score = 118 bits (295), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 143/539 (26%), Positives = 225/539 (41%), Gaps = 77/539 (14%) Query: 76 QPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLIN 135 QP L +K+ + A I+ A DPDREG+ + + D L+L Q++ I Sbjct: 53 QPTERGRDVLARLKKDVAAADRILLATDPDREGEAIAWHLADALKL--RDPQRITFTAIT 110 Query: 136 DLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSV 195 QA A R+ N S AR D + G ++ A L AG LS Sbjct: 111 KDKVQAAVAAPRRIDMNR-----VRSQEARRALDRIVGYRVSPA---LSDRAGQP--LSA 160 Query: 196 GRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDE-EG 254 GRVQ+P + LVV R+ EI +F + + + + A+W +P+ E E Sbjct: 161 GRVQSPAVRLVVDREREIASFKVTEHYGAELTFDNGDGTAWRAVWD----TKPHMAEGES 216 Query: 255 RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLD 314 ++ LA V + + V D + + PF+ S LQ A +R L + ++ Sbjct: 217 YIMDDALALRVA---AVRHVTVAEVADTEKGRAPAAPFTTSTLQQAAGQRLKLRPKKTME 273 Query: 315 ICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWD 374 + Q+LYE ITY R+D P AG + L +P R W Sbjct: 274 LAQRLYE-QGAITYHRTDA---PNMDDAGMEDIAAYARSAGLPLAEKP--------RRWK 321 Query: 375 DKK--VDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-DIA 430 K+ + H AI PT A T++E +Y LI ++ + DA++ + L A Sbjct: 322 AKEGAQEGHEAIRPTHAADLEAGETDDEKALYRLIWQRAVASQLADAIYAVRSVRLAGDA 381 Query: 431 KG---KFVAKARFLAEAGWRTLLGSKERDEENDG----TPLPVVAKGDELLCEKGEVVER 483 +G F A R L GW + + D +++G P+P +A+G L G ++ + Sbjct: 382 EGLAVAFTATGRTLQSPGWMAVYAADADDSDDEGEASNNPIPALAEGAGLTASSGRLLTK 441 Query: 484 QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTK 543 T+PP FT+ATL+ K+++++ G+G +T A IIE + RG++ + Sbjct: 442 HTKPPTRFTEATLV------------KEMERL-----GIGRPSTYAAIIENITGRGYVIE 484 Query: 544 K----------GRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 G I G+ F L D T E L QI+E + YQ + Sbjct: 485 GQKGYLTPSPIGETIRDALVGRFRFAEL-------DYTRGLEDELDQIAEAKADYQGVI 536 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteri... 897 0.0 UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteri... 693 0.0 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 663 0.0 UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 633 e-180 UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 630 e-179 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 627 e-178 UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salex... 626 e-178 UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A... 625 e-177 UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS1... 624 e-177 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 623 e-177 UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria R... 621 e-176 UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ... 617 e-175 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 616 e-175 UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei A... 615 e-174 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 612 e-173 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 608 e-172 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 607 e-172 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 601 e-170 UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii... 599 e-170 UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 ... 595 e-168 UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_... 595 e-168 UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum D... 594 e-168 UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=... 593 e-168 UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepI... 592 e-167 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 592 e-167 UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A... 590 e-167 UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BL... 589 e-166 UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105... 588 e-166 UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BG... 588 e-166 UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacte... 587 e-166 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 587 e-166 UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_... 586 e-166 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 585 e-165 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 584 e-165 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 583 e-165 UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organism... 583 e-165 UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria Rep... 582 e-164 UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE 582 e-164 UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_... 581 e-164 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 580 e-164 UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bactero... 580 e-164 UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales Rep... 579 e-163 UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q0... 578 e-163 UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q2... 577 e-163 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 577 e-163 UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT 574 e-162 UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase... 574 e-162 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 574 e-162 UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 572 e-161 UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62... 568 e-160 UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca D... 566 e-160 UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychroph... 566 e-160 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 566 e-159 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 565 e-159 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 563 e-159 UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extor... 562 e-158 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 562 e-158 UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6... 561 e-158 UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q... 559 e-157 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 558 e-157 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 557 e-157 UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermed... 555 e-156 UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria Re... 554 e-156 UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID... 553 e-156 UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ... 552 e-155 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 552 e-155 UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamie... 552 e-155 UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autot... 551 e-155 UniRef50_C6BT42 DNA topoisomerase type IA central domain protein... 551 e-155 UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q4... 550 e-155 UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP... 550 e-155 UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0... 549 e-155 UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0... 548 e-154 UniRef50_Q312M7 DNA topoisomerase n=1 Tax=Desulfovibrio desulfur... 548 e-154 UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_... 546 e-154 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 545 e-153 UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9... 545 e-153 UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM... 544 e-153 UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actino... 543 e-153 UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostri... 543 e-153 UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 ... 543 e-153 UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D... 541 e-152 UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1... 541 e-152 UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q... 539 e-151 UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_... 537 e-151 UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein... 536 e-151 UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacter... 536 e-151 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 536 e-150 UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum ... 536 e-150 UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E... 534 e-150 UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C... 533 e-150 UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepI... 533 e-150 UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8... 533 e-149 UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris... 531 e-149 UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID... 530 e-149 UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID... 530 e-149 UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotubercu... 528 e-148 UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium haf... 528 e-148 UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2M... 528 e-148 UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_... 527 e-148 UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3... 527 e-148 UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans AT... 525 e-147 UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=... 523 e-147 UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=... 520 e-146 UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0... 517 e-145 UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiacea... 516 e-145 UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocell... 516 e-145 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 514 e-144 UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnson... 514 e-144 UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID... 512 e-143 UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria... 511 e-143 UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damsela... 511 e-143 UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter prot... 511 e-143 UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group... 510 e-143 UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shew... 509 e-142 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 507 e-142 UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacter... 505 e-141 UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q18... 504 e-141 UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepI... 502 e-140 UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GF... 502 e-140 UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID... 499 e-139 UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria Re... 499 e-139 UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesti... 498 e-139 UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM ... 497 e-139 UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A... 492 e-137 UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus ... 491 e-137 UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis... 491 e-137 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 490 e-137 UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tas... 487 e-136 UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4... 486 e-135 UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=... 486 e-135 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 485 e-135 UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_... 485 e-135 UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=... 484 e-135 UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU... 483 e-135 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 482 e-134 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 481 e-134 UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 481 e-134 UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp.... 481 e-134 UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 481 e-134 UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum... 480 e-134 UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW... 478 e-133 UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL... 478 e-133 UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LR... 477 e-133 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 477 e-133 UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=... 475 e-132 UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytog... 474 e-132 UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus gr... 472 e-131 UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_... 471 e-131 UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP... 470 e-131 UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi... 470 e-130 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 469 e-130 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 469 e-130 UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_... 469 e-130 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 469 e-130 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 468 e-130 UniRef50_C4GAJ6 DNA topoisomerase n=1 Tax=Shuttleworthia satelle... 468 e-130 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 466 e-129 UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiac... 466 e-129 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 466 e-129 UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyti... 466 e-129 UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteob... 466 e-129 UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales Re... 465 e-129 UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID... 465 e-129 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 465 e-129 UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C... 464 e-129 UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms ... 464 e-129 UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C... 463 e-128 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 463 e-128 UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae Rep... 462 e-128 UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 462 e-128 UniRef50_C8L8E9 DNA topoisomerase n=7 Tax=Staphylococcus aureus ... 462 e-128 UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID... 462 e-128 UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeen... 462 e-128 UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP... 462 e-128 UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=... 461 e-128 UniRef50_B7U5A8 DNA topoisomerase n=2 Tax=Bacillus RepID=B7U5A8_... 461 e-128 UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP... 461 e-128 UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms R... 461 e-128 UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID... 459 e-127 UniRef50_A5ZNQ6 DNA topoisomerase n=2 Tax=Clostridiales RepID=A5... 459 e-127 UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum ... 459 e-127 UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B... 459 e-127 UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria R... 458 e-127 UniRef50_D1AS14 DNA topoisomerase type IA central domain protein... 458 e-127 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 457 e-127 UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 T... 457 e-127 UniRef50_C3RPW1 DNA topoisomerase n=1 Tax=Mollicutes bacterium D... 456 e-126 UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota Rep... 456 e-126 UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphi... 456 e-126 UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus ... 455 e-126 UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms Re... 455 e-126 UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa Rep... 455 e-126 UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota Re... 455 e-126 UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=... 454 e-126 UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1... 454 e-126 UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID... 452 e-125 UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsula... 451 e-125 UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LV... 451 e-125 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 450 e-125 UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Gro... 450 e-124 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 449 e-124 UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantar... 449 e-124 UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite gro... 449 e-124 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 448 e-124 UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepI... 448 e-124 UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_... 448 e-124 UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7... 448 e-124 UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7... 448 e-124 UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID... 447 e-124 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 447 e-124 UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1V... 447 e-124 UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms... 446 e-123 UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms ... 446 e-123 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 445 e-123 UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlan... 445 e-123 UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genom... 445 e-123 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 445 e-123 UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA)... 445 e-123 UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepI... 444 e-123 UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium R... 444 e-123 UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio ye... 444 e-123 UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepI... 443 e-123 UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QY... 443 e-122 UniRef50_C7X7R3 DNA topoisomerase I (Fragment) n=7 Tax=Bacteroid... 443 e-122 UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola ... 443 e-122 UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei Re... 443 e-122 UniRef50_B4U9A2 DNA topoisomerase n=1 Tax=Hydrogenobaculum sp. Y... 442 e-122 UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_... 442 e-122 UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepI... 442 e-122 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 441 e-122 UniRef50_D0NZ98 DNA topoisomerase, putative n=1 Tax=Phytophthora... 440 e-122 UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1... 440 e-121 UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax... 440 e-121 UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Enta... 440 e-121 UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 439 e-121 UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscole... 439 e-121 UniRef50_B6A9W0 DNA topoisomerase n=2 Tax=Eimeriorina RepID=B6A9... 439 e-121 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 438 e-121 UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum... 438 e-121 UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID... 438 e-121 UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepI... 437 e-121 UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angula... 437 e-121 UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 R... 437 e-121 UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_... 437 e-121 UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6... 437 e-121 UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_... 436 e-120 UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanob... 435 e-120 UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=... 435 e-120 UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=... 435 e-120 Sequences not found previously or not previously below threshold: >UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteria RepID=TOP3_ECOLI Length = 653 Score = 897 bits (2318), Expect = 0.0, Method: Composition-based stats. Identities = 653/653 (100%), Positives = 653/653 (100%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR Sbjct: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ Sbjct: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY Sbjct: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW Sbjct: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE Sbjct: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP Sbjct: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF Sbjct: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV Sbjct: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF Sbjct: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 Query: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY Sbjct: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 Query: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA Sbjct: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 >UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteria RepID=TOP3_VIBCH Length = 647 Score = 693 bits (1788), Expect = 0.0, Method: Composition-based stats. Identities = 375/641 (58%), Positives = 475/641 (74%), Gaps = 6/641 (0%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RLFIAEKPSLARAIAD LPKPH+K G I C NG +VTWCIGHLLEQ +PDAYD RY +W Sbjct: 3 RLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 N+ADLPI+PE+WQL+PR S ++QL V+++ L EA++I+HAGDPDREGQLLVDEV+DY ++ Sbjct: 63 NMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKV 122 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K++ VQR LI+DLN AV+RA+ LRSN EF+PL VSALAR+RADWLYG+NM+RAYT Sbjct: 123 PKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYT 182 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF---TA 238 +LG+ AGYQGVLSVGRVQTPVLGLVVRRDEEIE+F+ D+F + A I + A Sbjct: 183 LLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRA 242 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+PSEAC P+QDEEGR+ +R L ++V +RI+ QPA VT + ++APLP+SLSALQ Sbjct: 243 RWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQ 302 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 I+AAKR+ SAQ VLD+CQ LYE HKLITYPRSDCRYLP+EH A V+ AI+ +A ++ Sbjct: 303 IDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEM 362 Query: 359 LPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 + D +R++ W+D KVDAHHAIIPT + +++N L+ +E KVY LIARQYLMQF P Sbjct: 363 VTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYP 422 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 A++ + + +IA G F+AK R L AGW+ L G ++ EE +P + G L C Sbjct: 423 AAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEEC-VDKVPPLPVGIVLQCR 481 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 +GE+ +RQT+PPRHFT+ATLL AMTGIARFV DK+LKKILR TDGLGTEATRAGI++ LF Sbjct: 482 EGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLF 541 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 KRG L + + I ST AG+ L H+LP AT PDMTAHWE L I+EK YQ FMQ L Sbjct: 542 KRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQ 601 Query: 597 GTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRS 637 G L QLI+Q + PV + S + + + AP+ ++ Sbjct: 602 GRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKA 642 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 663 bits (1710), Expect = 0.0, Method: Composition-based stats. Identities = 261/649 (40%), Positives = 364/649 (56%), Gaps = 20/649 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L++ EKPS R I VL R +G++ G G VTWCIGHL+E PD Y + Sbjct: 1 MILYLCEKPSQGRDIGRVLGATSR-HEGYV-AGAGVCVTWCIGHLMEMVAPDGYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPI+P++WQL+ KQ VI+ L +E+V A D DREG+ + EVL+ Q Sbjct: 59 WRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQ 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++ R ++ L+ ++ +A+ L + PL + L R+RADW+ G+N+TRAY Sbjct: 119 ----YRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAY 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR GY GVLSVGRVQTP L LVV RD IENF D+FE+ A + F A W Sbjct: 175 TLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFA-LHRVHSGTFIAKW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P D EG L R LAE V++++ G +T KR E PLP LS LQ E Sbjct: 234 VPPPKP---CDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLPLELSTLQQE 290 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A++R+G+ A+ L+I Q LYE HK +TYPR+DCRYLP F AV+ ++ + L P Sbjct: 291 ASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTP 350 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDA 418 D +R++ W+DKK+ AHHAIIPTA I+ L+ EA +Y+LI R YL QF P Sbjct: 351 LVEGADAQLRSKAWNDKKITAHHAIIPTAAKINIDALSREEALLYDLIRRHYLAQFYPPF 410 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAKGDELLCE 476 + + VI+ +A F A R GW+ +L + + +E D LPVV G+ E Sbjct: 411 EYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIE 470 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 E+ ++QT+PP +T+ TL+ AM + + V+D L+KILR T G+GTEATRA I+E L Sbjct: 471 GAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILETLI 530 Query: 537 KRGFLTKKGRY-IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 KR L K+G+ + S AG+ L +LP T P TA WE L I+ + F+ Sbjct: 531 KRNLLAKQGKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLAKS 590 Query: 596 VGTLYQL---IDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 L +L + Q ++ + FRG+ P S D + PR++ K+ Sbjct: 591 ELWLNKLIHNVHQRQQLGLNPFRGL--PPSTSHTDPAQPTPRRQRRSKA 637 >UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AY08_RUBXD Length = 701 Score = 633 bits (1633), Expect = e-180, Method: Composition-based stats. Identities = 233/652 (35%), Positives = 348/652 (53%), Gaps = 36/652 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL +AEKPS+ R IA L + R+GD + G+G VVTW +GHL E A PDAY + Y R Sbjct: 1 MRLIVAEKPSVGRDIAGALGRHRREGDALV--GSGWVVTWALGHLAELAPPDAYGAEYKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W+L +LPI+PE+++++ P ++ ++R++ + S E+V+A D REG+L+ Y Sbjct: 59 WSLQNLPILPERFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACDAGREGELIF----AY 114 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + V+R ++ L P+A+ LR PL +A +RA ADW+ G+N TR Sbjct: 115 LYQLSRCEKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRAEADWIVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AY++ G VLSVGRVQTP L L+V R+ EIE+F + FF V A + + Sbjct: 175 AYSVRFSRPG--DVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARFARDG-KTYDG 231 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +W ++++E RL R AE + ++ G +V +R SE PL + L+ LQ Sbjct: 232 LW--------FREKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDLTELQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA------IS 352 A R+G +A+ L Q LYE KLITYPR+ RYL + + A ++ Sbjct: 284 RNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGLPELA 343 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 A LL + + R DD KV HHAI+PT R + L +EAKVY+L+AR++L Sbjct: 344 PFAGRLLAAGSL--PVGRRVVDDSKVTDHHAIVPTDRKPSGGLPPDEAKVYDLVARRFLA 401 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVAKGD 471 F P A F + + F++K R + EAGWR L +E + LP V G Sbjct: 402 VFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALPPVEAGQ 461 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 E K V E +T+PP ++++ LL AM + V+D++L++ ++ + GLGT ATRA I Sbjct: 462 EWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDS-GLGTPATRAAI 520 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQD 590 IE L K G++ ++ + + T G+AL L + P+MTA WE L +I + R D Sbjct: 521 IERLIKVGYVEREKKALVPTAKGRALISLLADSPLSSPEMTARWERRLARIERGEERRPD 580 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGS---ADKKKAAPRKRSAK 639 FM + G +++ +R + I APG GG A K +P + K Sbjct: 581 FMSDISGFAASVVEGVRRM---EGEKIAAPGGGGEALGACPKCGSPVVETKK 629 >UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=A1U3N5_MARAV Length = 722 Score = 630 bits (1624), Expect = e-179, Method: Composition-based stats. Identities = 321/649 (49%), Positives = 409/649 (63%), Gaps = 17/649 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG---QVVTWCIGHLLEQAQPDAYDSR 57 M L+IAEKPSLARAIA LP PH KG G+I CG G V+WCIGHLLE A+P Y+ Sbjct: 1 MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPA 60 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W + DLP+ PE WQL P+ SV Q V++ + +A I HAGDPDREGQLLVDEVL Sbjct: 61 WKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLR 120 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 YL + V+R LINDL P+AV RAI R N EF PL SALAR RADWLYGIN+T Sbjct: 121 YLG----TKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLT 176 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE--- 234 R YT+ + G QGV SVGRVQTPVLGLVV RD IE+F K ++ V+A E Sbjct: 177 RFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQ 236 Query: 235 -RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 F A W P + + + DEE RLL + +AE +V ISG+P + + E PLP S Sbjct: 237 RPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLS 296 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LSALQIEA + + + A++VLD Q LYE H+LITYPRSD RYLPEEHF+ R AV+ AI+ Sbjct: 297 LSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIAR 356 Query: 354 HAPDLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYL 411 APDL + R+ W+D+KVDAHHAIIPT R L+ E K+Y+LI+R YL Sbjct: 357 VAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYL 416 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVVAKG 470 MQF PDAV R+ + + I +F A + E GW+TL + +E +E + PLP + K Sbjct: 417 MQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKN 476 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + +LC + ER+TQPP+HFTDATLLSAMT IARFV D +L+K LR TDGLGTEATRA Sbjct: 477 EPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAA 536 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 II+ LF+R +L ++ R+I +TD GK+L +LPE PD TA WE+ L + + + Sbjct: 537 IIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRA 596 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 F++ L + + QA P PG+ K +A +R K Sbjct: 597 FLESLKDEIRGFMAQA---PAAGLANTETPGTAIHCPKCRAPMVEREGK 642 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 627 bits (1617), Expect = e-178, Method: Composition-based stats. Identities = 253/653 (38%), Positives = 359/653 (54%), Gaps = 16/653 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQ-VVTWCIGHLLEQAQPDAYDSRYA 59 M+LF+ EKPS IA VL ++G+G + +GQ VTW IGHL+EQ P+ YD + Sbjct: 6 MKLFLCEKPSQGNDIAKVLGAT-KRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFK 64 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 +W LPI+P KW L P+ KQ NV+ + + +A +V A D DREG+ + E+LD Sbjct: 65 KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA 124 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R Q++R ++ L+ ++ +A+ L++N E +PL + LAR+RADWL G+N +R Sbjct: 125 GF----RGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRL 180 Query: 180 YTILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+L + GYQG LSVGRVQTP L LVV RD EI+NF+ K F ++ + T Sbjct: 181 YTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQ 240 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSAL 297 P E Y D +G L + + +I A V S KRE ++APL F+LS L Sbjct: 241 YVIP----EQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDL 296 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA + +GL AQ VLDI Q LYETHK TYPR+DC YLPE FA ++ + Sbjct: 297 QSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNR 356 Query: 358 LLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFC 415 L P +++ + ++R W+DKK+ AHH IIPT + I +++ E K+Y+LI R+YL QF Sbjct: 357 LHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFL 416 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P + K I L + A+ L GW+ L G ++++ LP + +G Sbjct: 417 PVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQI 476 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E+ QT PP HFT+ TLL+AM ARFV D+ LK+ LR T+GLGTEATRAG I+ L Sbjct: 477 SDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGL 536 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +GFL KKG+ + +TD L +LP+M P +TA WE L QI+E+ + FMQ Sbjct: 537 IDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQ 596 Query: 596 VGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + L+ + + P G K+ + P + Sbjct: 597 EVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQ 649 >UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QVL1_CHRSD Length = 654 Score = 626 bits (1615), Expect = e-178, Method: Composition-based stats. Identities = 300/655 (45%), Positives = 403/655 (61%), Gaps = 27/655 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPSLARAIAD LP ++ +G++ CG ++WC+GHLLEQA PDAYD+RY + Sbjct: 1 MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGE-TCISWCVGHLLEQAPPDAYDARYQQ 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPIVP +W+L PR QL VI++ L A +VHAGDPDREGQLLV +V+ +L Sbjct: 60 WRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R + R L++DLN AV +A+ + N+ + L +A AR+RADW+YGIN++RA+ Sbjct: 120 W----RGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAW 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ GR AGYQGVLSVGRVQTPVLGL+VRRD +IE F + F+ + A + A W Sbjct: 176 TLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVE-HGTLRAWW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QP DE+GRLL R AE + + G ++ KR+++SAPLP+SLSALQ++ Sbjct: 235 QPQAPHPL--DEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVD 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA+R+ L A+ VLDICQ LYE H+LITYPRSDCRYLPE HFA ++ L Sbjct: 293 AARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRG 352 Query: 361 -QPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCPDA 418 D R+R W+DK+V AHHA+ PT R+ A LT +EA V+ LIAR L QF Sbjct: 353 WYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPL 412 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V R I F A+ R + E GW+ L +++ + PLP + +G+ Sbjct: 413 VTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTRD-----EAPPLPALHEGEAARVVDC 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 V +RQT+PP FTDA+L+ AM IAR+V D +K+ LR TDGLGTEATRAGI+E L R Sbjct: 468 AVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 G++ ++ + +T G+AL +LP+ ATRP+ TA WE L I+E + F+ LVG Sbjct: 528 GYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGD 587 Query: 599 LYQLIDQAKRTPVRQ---FRGIVAPGSGGSADKK---------KAAPRKRSAKKS 641 + QL+DQA +RQ G P S K+ ++PR+R+ K + Sbjct: 588 VRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSPRRRAGKST 642 >UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A3EW25_9BACT Length = 684 Score = 625 bits (1611), Expect = e-177, Method: Composition-based stats. Identities = 278/654 (42%), Positives = 382/654 (58%), Gaps = 17/654 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA+VLP PH+KG GF+E G G +VTWC GH+LE A P+ YD ++A Sbjct: 1 MRLFIAEKPSLGRAIAEVLPGPHKKGAGFLETGGG-IVTWCFGHILEAAPPEEYDRKWAA 59 Query: 61 W--NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W + DLPIVP+ W+L P PS QL VI++ L EASEIVHAGDPDREGQLLVDEVL+Y Sbjct: 60 WPGSSGDLPIVPKTWKLSPVPSAKAQLAVIRKLLGEASEIVHAGDPDREGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L R+ V R ++ L+ +AV +A+ LRSN EF + +A R+RADWL G+N++R Sbjct: 120 LG----NRKPVLRIWLSSLDEKAVRQALSGLRSNREFAAMKEAAQVRSRADWLVGMNLSR 175 Query: 179 AYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AY+I R G VLS+GRVQTP L LVV RD EIE+FV+KDFF V+A + P F Sbjct: 176 AYSIAARKNGNPVAVLSIGRVQTPTLKLVVDRDREIESFVSKDFFTVEATLEAPG-GAFK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +W P+E P D GR + R +A V N Q + +SE PL ++LS L Sbjct: 235 TVWMPAEN-HPALDAAGRCIDRTVALGVANGTKAQKG-ILDIGKTEKSEPPPLVYALSTL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 ++A+K++ +SA+ VLD Q LYE KL TYPR+DC YLP+ + +++A+ Sbjct: 293 TMDASKKYAMSAKEVLDTAQSLYE-KKLTTYPRTDCEYLPQTQWGEAREILSALGRLPGL 351 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCP 416 D R+R W+ +KV AHH IIPT + A L+E E ++++L+ R+YL QF P Sbjct: 352 SSAASQADSARRSRAWNTEKVTAHHGIIPTREAGRAGGLSEKEVRIFDLVCRRYLAQFYP 411 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE--RDEENDGTPLPVVAKGDELL 474 + + ++ + F AK + GW+++ G + D + PLP ++ GD ++ Sbjct: 412 PFRYTETIVRTRLGGEPFQAKGTTPLDTGWKSVYGPEPDREDRKEPEPPLPALSSGDPVV 471 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 VV R+T PP +TD TL++AM + R + + + KKIL TDGLGTEATRA I+E Sbjct: 472 ARDCSVVARKTTPPSPYTDGTLVAAMKNVHRAMSNPEDKKILNETDGLGTEATRASILET 531 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ-CRYQDFMQ 593 LF RG+L K R I ST G+AL ++ + P TA WE L I+ Q +F+ Sbjct: 532 LFSRGYLEKSKRAIRSTPRGRALIDAVEPIVASPVTTAVWERSLESIATGQGENSGEFLS 591 Query: 594 PLVGTLYQLIDQAKR-TPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 +V T+ +L A V G + GG + + PA Sbjct: 592 KIVDTVSRLTKTALALRVVIPVEGKICSECGGVLRRLEGKFGPFLGCSGYPACR 645 >UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS155 RepID=A3DB61_SHEB5 Length = 707 Score = 624 bits (1610), Expect = e-177, Method: Composition-based stats. Identities = 236/639 (36%), Positives = 355/639 (55%), Gaps = 21/639 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ IA VL ++GDG G+G VT+C+GH+L+QA+P+ Y+ + Sbjct: 1 MRLFLCEKPSQAKDIASVLG--CKRGDGVF-TGDGIAVTFCVGHVLQQAEPENYNPDFET 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ DLPI+P W++ P Q ++K+ L +A+E++ A D DREG+++ EVL+Y+ Sbjct: 58 WNIVDLPIIPTVWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYV- 116 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +QR ++ L+ ++++A+ LR N E L + L R+R DWL G+NMTR Sbjct: 117 ---NYKGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLC 173 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R GYQG SVGRVQTP L LVV RD ++E F + ++++ A F A W Sbjct: 174 TLLSREYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYDITGLFN--ATIPFKAKW 231 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + DE+GR L +HV+++ QP VT ++ KR+ P F L +LQ Sbjct: 232 QVPDNLG---DEQGRCLQVTTVDHVLSQCRDQPGTVTQFDTKRQKSKHPPLFFLGSLQKA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FG A+ VLDI Q LYE +K+ TYPR+DC YLP ++++ + V Sbjct: 289 MSAKFGYGAKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVVPAFAAW 348 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFCPDAV 419 D + + CW+DKK+ AHH IIP + + + E E +Y+ I ++YL QF P A Sbjct: 349 CSAADVNETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAE 408 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVVAKGDELLCEKG 478 IEL + A + GWR + G DE D + LP+++ G L + Sbjct: 409 DDATTIELMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDSANLPLLSIGQTLTAQ-F 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 + +++T+PP FT+ TL+ AM+ IA+F D LK IL+ T G+GTEATRA II+ L R Sbjct: 468 QREDKRTKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKAR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 GF+T G+ + S++AG++L +LP++ TRP MTA WE L +I+ DFM Sbjct: 528 GFVTVTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTF 587 Query: 599 LYQLIDQAK------RTPVRQFRGIVAPGSGGSADKKKA 631 + QL+ K + P + P S + Sbjct: 588 ITQLVSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQLSG 626 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 623 bits (1608), Expect = e-177, Method: Composition-based stats. Identities = 252/647 (38%), Positives = 369/647 (57%), Gaps = 24/647 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+++ EKPS AR IA VL K I +G VVTW GHLLEQA PDAYD R Sbjct: 1 MRVYLCEKPSQARDIAAVLGI-QSKDKSSITTADG-VVTWAFGHLLEQAPPDAYDDSLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W LA LPI P +W+++ + S Q I L A+E+V A D DREG+++ E++ ++ Sbjct: 59 WALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +VQR ++ L+ +V++A+ L+ ++E L SAL R+RADWL G+N+TRA+ Sbjct: 119 F----KGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ G + G +GV SVGRVQTP L LVV RD +IE+F +FE+ A + F+ W Sbjct: 175 TLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFF--EAGQSFSTKW 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E D+ GR + + + + V ++I+G+ V+ Y KR SE+ PLPFSLS LQ Sbjct: 233 KVPEGAG---DDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKT 289 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FGL AQ VLDI Q LYETHK TYPRSDC +LPEE F +++ A++ ++ Sbjct: 290 CSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQG 349 Query: 361 -QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDA 418 ++D ++ W+ KK+ AHHAIIPT ++ +++NE +VY LI RQYL QF P+ Sbjct: 350 IVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNY 409 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS---KERDEENDGTPLPVVAKGDELLC 475 + + I + I F + GWR L G + + +++ LP + +G L Sbjct: 410 EYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPL 469 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E+ +QT+PP +T+ TL+ AM I + + D LK IL+ G+GTEATRAGII L Sbjct: 470 SHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANL 529 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +RGF+TKKG+ + S+D G+ L +LP+ P +TA WE L +I+E + F + Sbjct: 530 IERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADV 589 Query: 596 VGTLYQLIDQAKRT------PVRQFRGIVAPGSGGSADKKKAAPRKR 636 V + +IDQ K+ P R P +K K+ Sbjct: 590 VKFITAIIDQIKKQHADAPAPTRPTAD--CPTCKAQGQAEKVYSIKK 634 >UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria RepID=Q3BT95_XANC5 Length = 670 Score = 621 bits (1603), Expect = e-176, Method: Composition-based stats. Identities = 249/640 (38%), Positives = 354/640 (55%), Gaps = 19/640 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS + I +L R G+G + G+G VTWCIGHL+E A P+AYD + R Sbjct: 1 MRLFLCEKPSQGKDIGRILGATQR-GEGCL-NGSGVTVTWCIGHLVEAAAPEAYDEQLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W++ LPI+P++WQ++ +P Q V+K L +A+++V A D DREG+L+ E++D Sbjct: 59 WSIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++R ++ LN ++ A+ +LR ++E +P+ SALAR+RADWL G+N++R + Sbjct: 119 ----YRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AGY GVLSVGRVQTP L LVV RD EI FV+ ++ + ++ T + FTA W Sbjct: 175 TVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSG-QAFTAQW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQI 299 + C D+ GR L +P+A+ +I A V S +R E PLPF L LQ Sbjct: 234 ISPDTC---TDDSGRCLQQPVAQQAAQQIRATGSAQVVSVETERVREGPPLPFDLGTLQE 290 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +K+ GL Q LDI Q LYETHK TYPRSD YLPE FA V++++ L Sbjct: 291 LCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLKTDFSLR 350 Query: 360 P-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 P +D R+R W+D KV AHH IIPT + ++ ++E E VY LI YL QF P Sbjct: 351 PIIDQLDRTQRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPH 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND----GTPLPVVAKGDEL 473 F + V L + A + + GWR +L + +E++D LP + +G Sbjct: 411 HEFDRTVANLSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSC 470 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 ++ +TQP R +T L+ +M G+A+ V D LK+ L+ T G+GTEATRA II Sbjct: 471 QVADVDLKALKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIS 530 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L RG+L KKGR I ++DA L ++P P TA WE L I Q F+ Sbjct: 531 GLIARGYLMKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIG 590 Query: 594 PLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKA 631 + QLI Q ++ G P G ++ Sbjct: 591 KQAAWISQLITQYASASLSIKVPHGPACPQCGAPTHQRSG 630 >UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ferrooxidans RepID=B7JBJ6_ACIF2 Length = 699 Score = 617 bits (1592), Expect = e-175, Method: Composition-based stats. Identities = 268/655 (40%), Positives = 374/655 (57%), Gaps = 28/655 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L+IAEKPSL + IA+ LP KG+GFI+CG VVTWC GH+ EQ +PD Y Sbjct: 1 MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVP 60 Query: 59 ------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 +W +LPI PE+W+ + + Q+ VI+ L +AS +V+AGDPDREGQLLV Sbjct: 61 TTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLV 120 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL+ L+ + R + L+ Q+V +A+ L+ N ++ L SA ARARADWL Sbjct: 121 DEVLEELRW----KGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLM 176 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T+ AG V+SVGRVQTP L LVV RDE+IE+F KD++ V Sbjct: 177 GMNLTRAFTLRNSGAG---VVSVGRVQTPTLALVVARDEKIEHFKPKDYY------VPRI 227 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLP 291 + F A W+ E E D EG L R A+ + +R + A V + + + APL Sbjct: 228 NAGFWATWELREDFEGV-DAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLG 286 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 FSL+ LQ + + G+SAQ+VLD Q LYE HK TYPR+DCRYLPEE +++ + Sbjct: 287 FSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGL 346 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 + L + D + ++ W+ KV AHHAIIPT S +++ AKVY++I R YL Sbjct: 347 AKAGFADLVK-AADSNRKSAIWNTGKVTAHHAIIPTG-SMQGSMSPAVAKVYDIIVRSYL 404 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-GTPLPVVAKG 470 QF P V+R L + A A AGW+ + G + D ++ P+P + KG Sbjct: 405 AQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKG 464 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 L + +V +QT+PP FTD +L+ AM+ I + V+D+ K L+ T GLGTEATRA Sbjct: 465 QVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRAS 524 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 IIE L RGFL +KG+ I ST AG+AL H+LP+ T P +TA WE L+ +SE + Q Sbjct: 525 IIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVTLQQ 584 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 F + + ++I+ AK T V G P SG K + +K+ PA Sbjct: 585 FEEAQRKFVVRMIEAAKATTVA--VGQARPTSGAGRGKSSTGKTRGVGQKTGPAC 637 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 616 bits (1590), Expect = e-175, Method: Composition-based stats. Identities = 245/663 (36%), Positives = 362/663 (54%), Gaps = 26/663 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA- 59 M+LF+ EKPS A+ IA V+ R+ + F GNG V W GHLLEQA+P+AY +++A Sbjct: 1 MKLFLCEKPSQAKDIARVIGAHQRRDNFF--QGNGVQVAWARGHLLEQAEPEAYGAQFAA 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 W + LP++PE+W++ + IK+ L +A+E+V A D DREG+++ E+L+ Sbjct: 59 PWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLEAC 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R++VQR ++ L+ ++ +A++ L + L + L RARADWL G+NMTR Sbjct: 119 H----YRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRL 174 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ R G+ G+LSVGRVQTP L L+VRR+ EI +FV+K F+ V A + F A Sbjct: 175 FTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGII-FQAH 233 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+P+ Y D+E R +H A+ V A V + N+ + PLPF L LQ Sbjct: 234 WRPASQ---YCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQ 290 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A++R+G SA VL+I Q LYE HK TYPR+DC YLP A V++A+S P L Sbjct: 291 QAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPAL 350 Query: 359 LP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 + P +R W+D K+ AHHAIIPT ++ +N + E E VY LI YL QF P Sbjct: 351 QNVLAQLQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQFLP 410 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD----EENDG------TPLPV 466 D + + LDI +FVAK + GW L E D EE + LP Sbjct: 411 DQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEAGTETLPS 470 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G+ + ++ +VV+ T PP+ +TD TL++AM + F+ D LKK+L+ GLGTEA Sbjct: 471 LHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLGTEA 530 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 TRAGII L R + ++ + + +TD G L +LP T P MTA WE L Q+++ Sbjct: 531 TRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQGNL 590 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSADKKKAAPRKRSAKKSPPA 644 FMQ + L LI + P+ + P G ++++ + + + P Sbjct: 591 SLDVFMQKQISWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPD 650 Query: 645 DEV 647 + Sbjct: 651 CKG 653 >UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V616_9FIRM Length = 711 Score = 615 bits (1585), Expect = e-174, Method: Composition-based stats. Identities = 283/647 (43%), Positives = 371/647 (57%), Gaps = 21/647 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ RA+A LP PHRKG G+IE G G VVTW GH+L QA+P+ YD R Sbjct: 1 MRLYIAEKPSVGRALATCLPAPHRKGSGWIETGGG-VVTWLFGHVLRQAEPEEYDPALKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+P++W L S +Q V+K + A EIVHAGDPDREGQLLVDEVLD+L Sbjct: 60 WRAEDLPILPKEWHLVVNESAAQQFAVVKGLIARADEIVHAGDPDREGQLLVDEVLDFLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LIN L+ +++ A++ LR N +F+PL +SALARARADWL G+N++RAY Sbjct: 120 ----NTKPVRRILINALDDKSIHDALNDLRDNGDFLPLKLSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGY-QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG+ + VL +GRV+TP L LVVRR+ EIE+F ++ V A T A E F A Sbjct: 176 TLAARRAGHARLVLPIGRVKTPTLALVVRREREIEHFTPATYYLVDALFRTEAGEPFRAR 235 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSLSAL 297 W+PSE P D EGRL+ R A+ PA +VT Y K++ E PLPFSLSAL Sbjct: 236 WKPSEERTPL-DPEGRLVDRAAADAAAASFGEPPADGVVTKYERKKKEEPPPLPFSLSAL 294 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA-- 355 Q+ A KR+G Q VLD QKLYE KL +YPRSD YLP ++ ++ + Sbjct: 295 QVLAGKRYGYEPQQVLDTAQKLYE-EKLTSYPRSDAEYLPVSQHKDAAKILGNLAALSDT 353 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQF 414 P D ++R W+D K+ AHHAIIPT + LT E +Y LIAR Y+ QF Sbjct: 354 PLAAWAQAADSAKKSRAWNDAKISAHHAIIPTTVPVNLARLTAVERNIYELIARAYIAQF 413 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------GSKERDEENDGTPLPVVA 468 CP+ V+ + E+ F A+ R AGWRT+ E+ + T LP + Sbjct: 414 CPNYVYDQTKAEVTHHGETFTARGRTERTAGWRTMYRAGKNESEDAEKEDEESTVLPPMK 473 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGD E ERQT+PP FT ATLL M I ++V+D+ KK+LR G+GTEATR Sbjct: 474 KGDAAAFVSAETKERQTKPPARFTPATLLQGMKEIHKYVKDEAAKKMLRDVSGIGTEATR 533 Query: 529 AGIIELLFKRGFLTK--KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 A IIE L +R FL K + + T L +LP+ T PD TA WE L +++ Sbjct: 534 ASIIEDLIRRKFLHAAGKKKVLTPTAEAYLLIDALPDTMTYPDATAIWEDQLHAMADGVG 593 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAP 633 ++F+ L D A+ + GI P G K+ Sbjct: 594 TPEEFLAGQAAFARDLCDAARTAQITGGEGIPCPACGRGVMLKRKGK 640 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 612 bits (1579), Expect = e-173, Method: Composition-based stats. Identities = 203/637 (31%), Positives = 330/637 (51%), Gaps = 38/637 (5%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA +L KG G++E GN +VTW +GHL+ A+P+ YD +Y Sbjct: 1 MKSLVLAEKPSVAREIARIL-NCTIKGKGYLE-GNKYIVTWALGHLVTLAEPEDYDEKYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W DLP++P + + Q +++ + + E++ A D REG+L+ ++ Sbjct: 59 TWRTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ +R I+ L +A+ RLR +E+ L SA+ RA ADWL G+N+T Sbjct: 119 QARC----QKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y LS GRVQTP L ++V R++EI+ FV DF+ VKA++ +F Sbjct: 175 RALTV-----KYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANL-----GKFQ 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A W+ R AE +VN++ + V + +SE PL + L+ L Sbjct: 225 AEWRDKSGKH------NRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTEL 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-SVHAP 356 Q +A K+FG +AQ L Q LYE HKL+TYPR+D RYL + + A+ + Sbjct: 279 QRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFA 338 Query: 357 DLLPQPVVDP-DIRNRCWDDKKVDAHHAIIP-TARSSAINLTENEAKVYNLIARQYLMQF 414 +L+ P I R D+ KV HHAIIP T R++ LT E +Y+LI R+++ F Sbjct: 339 ELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVF 398 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-----GTPLPVVAK 469 P +++ + + IA F A + + GW+ + ++ R+++ LP + K Sbjct: 399 YPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKK 458 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 GD++ + V+ QT+PP +T+A+LLSAM +F++D+ LK+ ++ + GLGT ATRA Sbjct: 459 GDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKES-GLGTPATRA 517 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 IIE + ++ ++G+ + T G L +P + D+TA WE L I+ + + Sbjct: 518 EIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRT 577 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGS 622 F+ + +++ + G P Sbjct: 578 KFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKC 614 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 608 bits (1568), Expect = e-172, Method: Composition-based stats. Identities = 235/659 (35%), Positives = 357/659 (54%), Gaps = 34/659 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L+I EKPS A+ +A V+ K ++GDGF+ G +V+TW GHLLE PD YD RY Sbjct: 1 MDLYICEKPSQAKDLAGVM-KASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI PE W+ R S KQ +++ + +AS I + D DREG+ + +LD + Sbjct: 60 WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++R + L+ ++++A++ ++ + V L +ALAR RADWL G+N++R Y Sbjct: 120 ----YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R+ G+ L VGRV TP + LV +RD EI F ++ + ++ + F A W Sbjct: 176 TVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQ-FAAQW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P E C DE+GR +++ AE V ++++G A+++ K ESAPLPF L++LQ Sbjct: 235 IPPEEC---SDEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLPFDLTSLQQY 291 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+KR+G +AQ VLD Q LYETHK TYPR+D RYLPE ++ A+ + ++ Sbjct: 292 ASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSG 351 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDA 418 DP + R ++D KV AHHAIIPT R+ ++E E +Y+ I R Y+ QF + Sbjct: 352 LVAGADPHRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEF 411 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK----------ERDEENDGTPLPVVA 468 F K IE+ + F + + + GW+ L S + D + LP V+ Sbjct: 412 EFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVS 471 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L E+ + T+P HFT+ATLL+AM IARFV ++ K+IL+ T GLGT ATR Sbjct: 472 QGEPALLNGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATR 531 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A II+ +G+ ++ + + +TD AL LP P MTA WE L +++ Sbjct: 532 ASIIQGAVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNM 591 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 FM+ + + Q+++Q K + K+ A K PP+ E Sbjct: 592 SVFMKQISTWICQMVEQLK-------------VAAPVLTKEGGAMAKAFEGAKPPSHEC 637 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 607 bits (1566), Expect = e-172, Method: Composition-based stats. Identities = 214/686 (31%), Positives = 354/686 (51%), Gaps = 72/686 (10%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR +++VL KG+G++E + ++TW IGHL+ A+PD YD+ Sbjct: 1 MKQLVLAEKPSVARDLSNVLGN-FNKGNGYLES-DAYIITWAIGHLVTLAEPDDYDAALK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 +W L LPI+P +++L+P + KQ N++K LH +I+ A D REG+L+ + Sbjct: 59 KWFLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGELIFRYIYK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ +R +++ P AV + D LR ++ L +A AR++ADWL GIN T Sbjct: 119 L----TDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA+T+ + +LSVGRVQTP L L+V R++EI FV + ++E+ A + + Sbjct: 175 RAFTV-----KHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYI 229 Query: 238 AIWQPSEACEPYQDE--------------------------------------------- 252 W E E Sbjct: 230 GKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAM 289 Query: 253 EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNV 312 + + R A + +++GQP V S K E PL F+L+ LQ EA K+FGLSA Sbjct: 290 QTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKT 349 Query: 313 LDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS---VHAPDLLPQPVVDPDIR 369 L + Q+LYE+ KLITYPR+D R + E + A++ + + + Sbjct: 350 LSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKERKAFLN 409 Query: 370 NRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELD 428 R +D KV H A+IPT ++ L+ +E +VY+L+ R++L F P A + + + + Sbjct: 410 KRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITE 469 Query: 429 IAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQP 487 + + F+++ R + GW+T+ +++ +++ LPV+ + +L K ++ E++T P Sbjct: 470 VKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNP 529 Query: 488 PRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY 547 P+ +T+A LLS M G R + D++LK+ +R + GLGT ATRA IIE L K G++ ++ + Sbjct: 530 PKRYTEAALLSVMEGAGRLLNDEELKEAMRGS-GLGTPATRAAIIERLLKVGYIERRKKT 588 Query: 548 IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + T+ G+ L +PE P+MTA WE L I + Q +FM ++ Q+++ A+ Sbjct: 589 LLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELAR 648 Query: 608 RT-----PVRQFRGIV--APGSGGSA 626 R P+R R I+ P G Sbjct: 649 RQKTEGEPLRNNRDIIGKCPLCGRPV 674 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 601 bits (1549), Expect = e-170, Method: Composition-based stats. Identities = 215/645 (33%), Positives = 341/645 (52%), Gaps = 39/645 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L I EKPS+ + IA VL + K DG++E +V+W GHL+E A P YD + Sbjct: 1 MKTLVITEKPSVGKDIASVLGRFESK-DGYLE-NEKYIVSWAFGHLVELADPSVYDPVFK 58 Query: 60 RWNLADLPIVPEKWQLQPRP-SVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVL 116 +W+LA LPI+P+ ++L S KQL +K+ L+ E S++V+ D REG+ + + Sbjct: 59 KWDLATLPIIPDSFKLVEIAGSSAKQLRTLKKLLNSAEVSQVVNGCDAGREGESIFRRIY 118 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + R+ ++R +++ P AV+ A LR E+ L +A AR +ADWL G+N Sbjct: 119 HFCGC----RKPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEARGQADWLVGLNG 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA+T+ + VLSVGRVQTP L L+V R+ EI NFV ++EV T + Sbjct: 175 TRAFTVR-----HGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQTDNGM-Y 228 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLS 295 W ++++E RL +R A ++ ++S + V S K E F+L+ Sbjct: 229 KGKW--------FREKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNLN 280 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQ E +R+G +AQ VLDI Q LYE HKL+TYPR+D R+L + + + Sbjct: 281 DLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNAP 340 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQF 414 P P + R DD K+ HHAIIPTA S L++ E K+Y+L+ R++L F Sbjct: 341 KYAELIPDTLPGLSKRYVDDGKITDHHAIIPTAVDPSKAQLSDQEKKIYDLVVRRFLSIF 400 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-------EENDGTPLPVV 467 P+A + + + A F ++ R AGW+ + +++ ++ + LP + Sbjct: 401 YPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQALPPL 460 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G + K E++E+QT+PP+ FT+AT+L+AM +FV+DK++ ++L+ T G+GT AT Sbjct: 461 TQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIGTPAT 520 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RA IIE L K G++ + + + T G+ L +P+ ++TA WE L ++ E Q Sbjct: 521 RAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPKQLKSVELTASWEDGLRRVEEGQQN 580 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGI------VAPGSGGSA 626 ++Q + +L+ A+ V Q G P G Sbjct: 581 AALWIQDIQAYTRELVVLARNQEVSQGVGTARDTLGKCPVCGRDV 625 >UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii LLAP12 RepID=C6N6E9_9GAMM Length = 668 Score = 599 bits (1545), Expect = e-170, Method: Composition-based stats. Identities = 241/659 (36%), Positives = 356/659 (54%), Gaps = 23/659 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFI EKPS A+ IA VL R D E GN VTWC+GHLLE A PD Y Sbjct: 1 MRLFICEKPSQAKDIATVLGATTR-TDACFE-GNEIAVTWCVGHLLELAPPDHYCDSIKP 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W + LP+VP++W L P+ KQLN I + L +A +V A D DREG ++ EVLDY Sbjct: 59 WRMEVLPVVPKQWVLMPQEKTKKQLNAIGKLLKQARSVVIATDADREGDVIGREVLDYF- 117 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R ++ L+ +++++A+ ++ + L + L R RADWL G+N+T A Sbjct: 118 ---NYQGPVERLWLSALDEESIKKALHSIKPGAATECLYQAGLGRQRADWLMGMNLTMAV 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L G QGVLSVGRVQTP L LVV RD IE F A+D++ +KA E F W Sbjct: 175 SSLYALPG-QGVLSVGRVQTPTLKLVVDRDLGIEQFKAQDYYVLKALCENINQEPFWVTW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 E E D++G+ + + + V +I+G+ VTS+ + + E+ PL SLS+LQ Sbjct: 234 ---EIPEELSDDDGKCIQKASIDEVARKINGKAGRVTSFKELDKREAPPLCLSLSSLQQL 290 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+ + GLSA++ LDI Q LYE HK +YPR+DC YLP+ FA AV +A+ P++LP Sbjct: 291 ASSQLGLSAKHTLDIAQALYEQHKATSYPRTDCGYLPDSQFAEAGAVFDALKQIDPEVLP 350 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 ++++ W+ K+ AHH IIPT + + +TE+E VY LI YL QF + Sbjct: 351 LIERCSLQLKSKAWNSDKITAHHGIIPTLNPKVNLKTMTESERNVYQLIRAYYLAQFLGE 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-----GTPLPVVAKGDE 472 F + + LDI F A A GW++ + EE + +P + + Sbjct: 411 YEFVQRQVTLDIEAYTFKASAHLPGVLGWKSAIKPIRDLEEEELDTDASESIPKLHDQEP 470 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + R+T+P FT+ +L++AM IA ++++ LKKIL+ T G+GTEATRA I+ Sbjct: 471 VSIQKLKPDSRKTKPKSRFTEGSLIAAMKSIANYIENPQLKKILKETSGIGTEATRANIL 530 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E L R +L ++G+ + ST G+ L LP+ T P TA WE +L I+ + DF+ Sbjct: 531 ETLLSRAYLKRQGKQLISTPKGRELIQRLPQSITNPATTALWEQMLEDIALGKHALDDFL 590 Query: 593 QPLVGTLYQLIDQA-KRTPVRQFRG----IVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + TL ++ Q K+ P G P + K++ + P + Sbjct: 591 EEQSDTLSGMLVQLEKQKPASHILGSNSTYSCPDCQKTLMKRQGSKGAWWGCSGYPQCK 649 >UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 RepID=Q5DY58_VIBF1 Length = 664 Score = 595 bits (1535), Expect = e-168, Method: Composition-based stats. Identities = 266/659 (40%), Positives = 372/659 (56%), Gaps = 26/659 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA L + G+I C NG VVTWCIGHLLE A+P+AYD +Y Sbjct: 1 MRLFIAEKPSLGRAIAASLGV-IKNEKGYITCKNGDVVTWCIGHLLELAEPEAYDKKYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI P++W L P S +QL+V+ + +A+ +V+AGDPDREG LL++EV++Y Sbjct: 60 WSLDTLPIFPKEWILIPTDSSKEQLDVVLEQIKKATVLVNAGDPDREGDLLINEVIEYAN 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ + ++ R LINDLN +A+E A++ L NS+ +P+ +AL R+RADWL G+N+TRA Sbjct: 120 VSNDIKENALRVLINDLNSKAIETALNNLEPNSKRIPISNAALCRSRADWLLGMNITRAC 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++L + G+ VL VGRVQTP + LVV+RD EI NF DFFEV+A F A Sbjct: 180 SVLAKRKGHDNVLHVGRVQTPTIQLVVKRDIEIANFKPVDFFEVEAQFTHADIP-FKAKL 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + R+ + LAE ++ I+GQ A VT KR PLPFSL LQ Sbjct: 239 Q----------NKKRIDKKDLAESMITNITGQSATVTLCETKRAKSQPPLPFSLRTLQEA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + ++G A+ LDI Q LYETHK+ +YPR+D YL ++ + L Sbjct: 289 MSSKYGYGAKETLDIAQSLYETHKITSYPRTDKNYLSTIKEDEIQLIIENLEGLNDTPLA 348 Query: 361 QPVVDPD--IRNRCWDDKKVD--AHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 Q D D +R+ CW+DKK++ AH AIIPT R+ ++ L+E E VY IA +YL QF Sbjct: 349 QWASDADMSLRSPCWNDKKLEGSAHTAIIPTTRAPDLDALSEAEHNVYTAIASRYLAQFY 408 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P A I++ + +F + + GWRT+LG ++ D E LP + K + C Sbjct: 409 PTAEDDNTTIKIQSGEHEFKTTGKIEIKKGWRTVLGKEKNDTEEQS--LPSLTKDQSIDC 466 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EV+ ++T P+ +T+ TLLSAM I + V D LK L+ T GLGTEATRAGIIE Sbjct: 467 TNAEVISKKTSAPKPYTEGTLLSAMCNIGKEVTDPALKAKLKETAGLGTEATRAGIIEKA 526 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +R +LT KG+ I ST K L +LP P +TA WE L + +C + F+ + Sbjct: 527 KEREYLTLKGKNIVSTPLAKMLVMALPNKVRDPAITAIWEQQLDVVERGECSVETFINAI 586 Query: 596 VGTLYQLIDQAKRTP----VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 T+ L+D K + + P SG + +K K+ G+ Sbjct: 587 EKTVQSLVDDLKSGKEPFTLSKSNAPACPQSGCTGFALPFEGKK---SKAHQCHVCGTK 642 >UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_9FIRM Length = 821 Score = 595 bits (1534), Expect = e-168, Method: Composition-based stats. Identities = 254/652 (38%), Positives = 372/652 (57%), Gaps = 27/652 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ R +A L P + DG++ +G VVTW GH+L QA+P+ YD +Y R Sbjct: 1 MRLYIAEKPSVGRELAKCLTGPVTRRDGYLVTKDG-VVTWLFGHILRQAEPEEYDPKYKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+PE W+L KQ ++K + +A EIVH GDPDREGQLLVDEVLDYL Sbjct: 60 WRADDLPIIPEHWKLFVDKDCEKQFAIVKSLIEKADEIVHGGDPDREGQLLVDEVLDYLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ V+R L+N L+ +++++A LR N +F L SALARARADWL G+N++RAY Sbjct: 120 ----NKKPVRRILLNALDEKSIKKANASLRDNRDFFNLKQSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG++ VL +GRV+TP L LVVRR+ EIE+F ++ ++ F A Sbjct: 176 TLAARRAGHERLVLPIGRVKTPTLSLVVRREREIEHFKPVTYYLIRGTFQHEN-GSFEAQ 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP--AIVTSYNDKRESESAPLPFSLSAL 297 W+P + D E RL+ + +A+ + P A++++Y ++ E PLPFSLS L Sbjct: 235 WKPKDTMAGL-DSENRLIDKKIADEKLAFFEELPHDAVISAYQKAKKQEPQPLPFSLSTL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A KRFG + Q VLD QKLYE KL TYPRSDC YLP +++ ++ Sbjct: 294 QVLAGKRFGYAPQLVLDTAQKLYE-KKLTTYPRSDCEYLPTNQLGEAATILSHLAKAGDA 352 Query: 358 LLPQ--PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQF 414 + +P ++R W+DKK+ AHHAIIPT + + +T+ E +Y+LIAR YL QF Sbjct: 353 QVAAWVKAANPKQKSRAWNDKKISAHHAIIPTTVQADVTKMTQEERNLYHLIARAYLAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-----------GTP 463 P + + +E+ F A R + GW+ + S+++ +E+D Sbjct: 413 YPVHTYDQTKVEVQYKDETFTASGRTERDLGWKVMYQSQKKKQESDEEDDKEDKEESAKT 472 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + K D + ++G ++E+ T+PP FT +TLL+ M I ++V++ + KK L+ G+G Sbjct: 473 LPAMKKKDAVAWQRGRMLEKMTKPPTRFTASTLLAGMKEIHKYVKNPEAKKQLKDVYGIG 532 Query: 524 TEATRAGIIELLFKRGFL--TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 TEATRA II+ L +R F+ K +Y+ T A L +LP+ T PD TA WE L + Sbjct: 533 TEATRATIIDDLIRRKFMKAEGKKKYLVPTPAAYLLVDALPDELTYPDSTAIWEDKLHSM 592 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAP 633 SE + DF+Q + +L +A + V P K+ Sbjct: 593 SEGEGSLADFLQGQIAFTRKLCAKATDVHMEVKGENVCPRCHQGVLTKRKGK 644 >UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LL88_HALO1 Length = 867 Score = 594 bits (1532), Expect = e-168, Method: Composition-based stats. Identities = 235/663 (35%), Positives = 355/663 (53%), Gaps = 51/663 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IA V+ K +G++E G G V+WCIGHL E +P YD+++ W+ Sbjct: 6 LIIAEKPSMARDIARVVG-ARSKREGYLEGG-GYWVSWCIGHLAELCEPHEYDAKWKSWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P++ +++P S L V+ R + E IV+A D REG+L+ V Sbjct: 64 PSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHV----H 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ V+R I+ L +A+ R + LR +EF L +A ARA ADWL G+N TRA Sbjct: 120 ALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRAL 179 Query: 181 TILGRNAGYQGVL-SVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE--RFT 237 T L R+ G +G+L SVGRVQTP L L+VRR+ EIE+F +K F++V A P + + Sbjct: 180 TGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYE 239 Query: 238 AIWQ-PSEACEPYQD-----------------------EEGRLLHRPLAEHVVNRISGQP 273 IWQ P EA + D + R+ R A+ + + + G+ Sbjct: 240 GIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRA 299 Query: 274 AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDC 333 +T K E PL F L+ LQ A +RF +SA+ L++ Q LYETHKLITYPR+D Sbjct: 300 GTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDA 359 Query: 334 RYLPEEHFAGRHAVMNAISVHAP---DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS 390 RYL ++ ++ A++ P D R +D+ +V HHAIIPTA++ Sbjct: 360 RYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKA 419 Query: 391 SAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL 449 + L+ +E ++Y+LIAR++L PDAV+ + I +A F + R AE GW+ Sbjct: 420 PSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQ- 478 Query: 450 LGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQD 509 + + PLP + + E+ EV E +TQPP+ +++A+LL AM R + D Sbjct: 479 -AEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDD 537 Query: 510 KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRP 568 L++++R GLGT ATRA IIE L KR ++ ++GR + T+ G+AL S+P E Sbjct: 538 PGLRRVMRDA-GLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSA 596 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR-------TPVRQFRGIVAPG 621 ++TA WE L I+ + FM + G + +++D + +P + G+ P Sbjct: 597 ELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGL-CPV 655 Query: 622 SGG 624 G Sbjct: 656 CNG 658 >UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=A1TJM5_ACIAC Length = 680 Score = 593 bits (1528), Expect = e-168, Method: Composition-based stats. Identities = 236/666 (35%), Positives = 339/666 (50%), Gaps = 28/666 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+ + EKPS + IA VL R+ + G G VTW IGHL+E A P+AY + R Sbjct: 1 MRVVLCEKPSQGKDIARVLGA--RQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPIVP++W+ + Q V++R L +ASE++ A D DREG+++ E+++Y Sbjct: 59 WSLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R +QR ++ LN ++ +A+ LR++ E +PL ALAR+ ADWL GIN+TR + Sbjct: 119 ----YRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AG+ GVLSVGRVQTP L LV RD EI FV F+ ++ + + F+A W Sbjct: 175 TLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLS-AGAQAFSAHW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQI 299 P D GR L + A+H + A VT + +R E PLPF LS LQ Sbjct: 234 VPP---ATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLPFDLSTLQE 290 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 ++R GL Q LDI Q LYETHK TYPR+D YLPE V+ ++ P L Sbjct: 291 VCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPALQ 350 Query: 360 P-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFCPD 417 P +D R+R W+ K+ AHHAIIPT + + ++E E VY LI YL QF P Sbjct: 351 PLMQRLDLGQRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLPH 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--------GSKERDEEND-----GTPL 464 + + ++ L A + + +AGW+ G++ + E D L Sbjct: 411 YAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQAL 470 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + +G ++ T+ P +T L+ AM +A+ V D LK+ LR T G+GT Sbjct: 471 PTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIGT 530 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 EATRA II L RGFL +KGR + ++ L ++P P TA WE L I + Sbjct: 531 EATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEAR 590 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 F+ + QL++Q + +R G P G + K+ + Sbjct: 591 TMDLDTFVSKQAAWVSQLVEQHREATLAIRVPAGPPCPLCGAATRKRTGKTGAFWSCSRY 650 Query: 643 PADEVG 648 P + Sbjct: 651 PDCKGT 656 >UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepID=B2RH95_PORG3 Length = 710 Score = 592 bits (1527), Expect = e-167, Method: Composition-based stats. Identities = 212/659 (32%), Positives = 334/659 (50%), Gaps = 35/659 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+ R IA VL + G++E GNG VTW GHL +P Y + R Sbjct: 36 MIVCIAEKPSVGREIAAVLGAT-KAYKGYME-GNGYQVTWTFGHLCALKEPHDYAPEWKR 93 Query: 61 WNLADLPIVPEKW--QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+++ LP++P ++ +L S+ +Q I++ +HEA +V+ GD +EG+L+ VL Sbjct: 94 WSISSLPMIPLRFGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDAGQEGELIQRWVLQK 153 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 V+R I+ L +++ RLR + EF L + LARA DWL G+N TR Sbjct: 154 TGCTC----PVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAIGDWLLGMNATR 209 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ R + VLS+GRVQTP L L+VRR EIE+F + ++EVK Sbjct: 210 LYTL--RFGSNRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVK------------- 254 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + +GR A V ++G P VTS K+ E P F L+ LQ Sbjct: 255 ---TIYRDTVFNATKGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLTGLQ 311 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +E KRF ++A L Q LYE K+ +YPR D YL ++ F ++ +S + Sbjct: 312 VECNKRFAMTADATLRTIQSLYE-KKITSYPRVDTTYLSDDVFEKVPNILQGLSDYTLLT 370 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 P + +D+ K+ HHAIIPT + S ++E+E +V++L+AR+++ F PD Sbjct: 371 APLRSSKLKKSKKVFDNSKITDHHAIIPTGQPSH-GMSEDERRVFDLVARRFIAVFYPDC 429 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE----NDGTPLPVVAKGDELL 474 +F + + AK +F + + E GWRT+ + D++ ++ LP+ ++G+ Sbjct: 430 IFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFSEGESG- 488 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 EV E+ TQPP+ +T+ATLL AM + V+D++L+ L+ +G+G +TRA IIE Sbjct: 489 VHTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKE-NGIGRPSTRAAIIET 547 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LFKR ++ K+ + + +T G +L ++ E+ ++T WE L +I DF+ Sbjct: 548 LFKRNYIYKEKKNLKATPTGMSLIATIDYELLKSAELTGQWEYKLRRIERGDYSAADFIN 607 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 L L LI ++ P + + KKK A + + G G I Sbjct: 608 ELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADKPMQKQLDLTCPVCGKGII 666 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 592 bits (1526), Expect = e-167, Method: Composition-based stats. Identities = 209/641 (32%), Positives = 319/641 (49%), Gaps = 54/641 (8%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA VL + E G +VTW +GHL+E P+ YD +Y Sbjct: 1 MKSLVLAEKPSVARDIARVLG-CKETHKPYFE-GPRYIVTWALGHLVELKMPEDYDRKYE 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W L DLPI+P+K L+ + Q I+R +++ A D REG+L+ +L+ Sbjct: 59 TWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILE 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + + + R I+ +A+ +L+ ++F L SA+ RA ADWL G+N++ Sbjct: 119 MIGWT----KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVS 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS GRVQTP L +++ R+ EI++FV ++ ++A I T Sbjct: 175 RALTT-----KYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKI-----GSIT 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A+W+ RL + A+ ++ R+ GQPA V S KR+SE APLP+ L+ L Sbjct: 225 AVWERHGG--------HRLFDQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDLTEL 276 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q +A KRFG SA+ L + Q+LYE HKL+TYPR+D RYLP + A + A+ D Sbjct: 277 QRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGYED 336 Query: 358 LLPQPV--VDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQF 414 ++ + R ++D KV HHAI+PT R + L+ +E K+Y+LIAR++L F Sbjct: 337 VIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFLALF 396 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P DI FVAK + G++ +LG +E D + L +A+G L Sbjct: 397 FPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLGKEETDAK---PTLSHLAEGQTLP 453 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 + E + T+PP +++A LL+ M LGT ATRA IIE Sbjct: 454 SVQLEREQSFTEPPARYSEADLLAQMEKYG-----------------LGTPATRADIIER 496 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 L + + +K + T GK L + E P++TA WE L I+ + Q F+ Sbjct: 497 LVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQFLAN 556 Query: 595 LVGTLYQLIDQAKRT----PVRQFRGIVAPGSGGSADKKKA 631 + QL+ + K++ + P G ++K Sbjct: 557 IRRQTQQLVAEIKQSEQVYKAPNLTNLTCPECGALLKERKT 597 >UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A8MIQ9_ALKOO Length = 716 Score = 590 bits (1520), Expect = e-167, Method: Composition-based stats. Identities = 215/657 (32%), Positives = 350/657 (53%), Gaps = 42/657 (6%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RL IAEKPS+A+ IA VL K +G+IE G+ ++TW IGHL+ P+ YD RY +W Sbjct: 3 RLVIAEKPSVAKDIAKVL-NCKEKREGYIE-GSDYIITWAIGHLVILCDPEEYDIRYKKW 60 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 + LPI+P+K +L+P P KQ ++K + + EI+ A D REG+L+ + + Sbjct: 61 DFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYELA 120 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + R+ QR I+ L + + + L+ + L SA R+ +DWL GIN +RA Sbjct: 121 KC----RKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRA 176 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 Y+I Y +L +GRVQTP L ++V RD EI++FV KD++EVKA ++ I Sbjct: 177 YSIQ-----YGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADF-----GNYSGI 226 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W E E ++ AE + N++ + +VT + K+ + P + L+ LQ Sbjct: 227 WIDLEKN------ESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQR 280 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 ++ K+FG +AQ LDI Q LYE K ITYPR+D R+L ++ +++N I + Sbjct: 281 DSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEF 340 Query: 360 P---QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 + + + R +D+KV HHAIIPT + +N +E E +Y+LIAR++L F Sbjct: 341 TSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAVFY 400 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 PD + V+ +A F + + GW+ L KE E + L + KG Sbjct: 401 PDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEV--ETKESTLIHIKKGSSSTL 458 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 + E+ ++QT+PP + +A LL +M +F++D++LK+ L+++ G+GT ATRA IIE + Sbjct: 459 KSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSS-GIGTPATRASIIERI 517 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 G++ +KG+ + ST+ G+ L + + P++T WE L +I++ Q FM+ + Sbjct: 518 ISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFMEGI 577 Query: 596 VGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP----PADEVG 648 +I+ ++ + +V G + KK + S+ SP PA +VG Sbjct: 578 GRFTKFIIEDVQKN----TKNVVFEGYSKNRGKKSSGT---SSYNSPIGICPACKVG 627 >UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BLQ5_VEIPT Length = 773 Score = 589 bits (1519), Expect = e-166, Method: Composition-based stats. Identities = 265/637 (41%), Positives = 372/637 (58%), Gaps = 39/637 (6%) Query: 1 MRLFIAEKPSLARAIADVLP--KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MRLFIAEKPS+AR I+ LP K +K +G+ G+ VVTW +GH+L QA+P YD +Y Sbjct: 1 MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDD-VVTWVVGHVLHQAEPGDYDDKY 59 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 RW DLPIVP +W+L S +Q ++K + +A IV+AGDPDREGQLLVDEVL Y Sbjct: 60 IRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + VQR L+N L+ +++ A+D LR N +F L SALARARADWL G+N++R Sbjct: 120 VG----NTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT+ R G + L +GRV+TP L LVVRR+ E+ F D+F VK P F A Sbjct: 176 AYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHPNGV-FWA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSAL 297 WQP++ + D +GRL+++ +A+ +V ++ P ++ + ++ + LP SLS+L Sbjct: 235 TWQPTDEQKGL-DPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A K F Q VLD QKLYE KL TYPRSDC YLP + R+A++N + + Sbjct: 294 QVLAGKAFSYDPQTVLDTAQKLYE-KKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDE 352 Query: 358 LLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 L Q D D I++R W++KK+ AHHAIIPT + IN L++ E +Y LI++ Y+ QF Sbjct: 353 RLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG---------------SKERDEEN 459 + ++ + I ++ K +FVA R + E GW+ L + ER E+ Sbjct: 413 YGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAES 472 Query: 460 DGTP--------LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 D LP V K D +L V +QT+PP FT +TLL AM I +FV+++D Sbjct: 473 DPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNED 532 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLPEMATRPD 569 LKK L+A G+GTEATRA II+ L RGF+ G+ + T+ G L +LPE PD Sbjct: 533 LKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPD 592 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 TA WE L +SE + F+ + L LID+ Sbjct: 593 ETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKL 629 >UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105 RepID=A6GUS8_9BURK Length = 670 Score = 588 bits (1516), Expect = e-166, Method: Composition-based stats. Identities = 254/644 (39%), Positives = 367/644 (56%), Gaps = 30/644 (4%) Query: 1 MRLFIAEKPSLARAIADVLPK------PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY 54 MRLFIAEKPS+ + IA L P K IE G G VVTW GHLLE A P+ Y Sbjct: 1 MRLFIAEKPSMGKEIAKNLGGKMVNQGPAGKPPTHIEVG-GDVVTWGFGHLLEMAPPEHY 59 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+ LPI P+ ++L P+ + Q++ IK L +AS +V+AGDPDREGQ +VD Sbjct: 60 SEAFKKWSFDTLPIEPKSFELLPKSNAKAQISTIKALLKKASTVVNAGDPDREGQWVVDS 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSN--SEFVPLCVSALARARADWLY 172 +L++ + VQR ++ L+ +V++A+ L+ N +F+ SA+ R R+DW + Sbjct: 120 LLEHFG----NTKPVQRIILQALDEVSVKKALANLQPNTSPQFIGWKNSAIGRQRSDWFW 175 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T++ G V+S+GRVQTP LGLVV RD IENF KDF+ V A IV A Sbjct: 176 GMNLTRAHTLVSNVKG--QVVSIGRVQTPTLGLVVARDLAIENFKPKDFYAVSAQIV-GA 232 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + F+A W+PS+A DE GR+L +A+ V +I Q A VT++ + +SAPLP+ Sbjct: 233 EPVFSAKWKPSDAVPV--DESGRVLDANIAQTVCAKIKSQTASVTAFEAVDKKQSAPLPY 290 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 SLS+LQ+ A+K+ GL AQ VLDI Q LYE KL +YPR+DC YLPE A + + Sbjct: 291 SLSSLQLAASKKLGLGAQRVLDIAQTLYE-QKLTSYPRTDCPYLPESQHASAELIAKCLP 349 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 +L+ I++ W+D KV AHH IIPT + NL+ A VY++I YL Sbjct: 350 EKYSELV--KGASFSIKSGAWNDSKVTAHHGIIPTGQ--KANLSGELAAVYDMIVLAYLA 405 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 QF P V+++ I L++A KF A + GW+ + GS+E +E D LPV+ G Sbjct: 406 QFYPPFVYKQTTISLEVAGEKFTASGKAPISQGWKVVFGSEESEEGEDKQTLPVLQVGQS 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L+CE +V ++T PP FT+ TL+ AMT + + V D ++KK L+ T G+GTEATRA II Sbjct: 466 LICETAQVDAKKTTPPLRFTEGTLIQAMTNVHQLVDDPEIKKRLKETAGIGTEATRANII 525 Query: 533 ELLFKRGFLT-----KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 E L R F+ K + ST G+ L LP+ +T +E L +++ + Sbjct: 526 ETLKMRKFIEIPDSGKDKGKLVSTQNGRKLIAKLPDSLKSAGITGLFEQALESVAKGETS 585 Query: 588 YQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKK 629 FM+ + + ++ A++ VAP G +K Sbjct: 586 LDVFMEKQTAFVKKYVEMARKEAPATASASTPVAPSVGCPVCEK 629 >UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BGR1 RepID=C5A9D2_BURGB Length = 722 Score = 588 bits (1515), Expect = e-166, Method: Composition-based stats. Identities = 251/695 (36%), Positives = 368/695 (52%), Gaps = 54/695 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+I EKPS+A+A+ LPKPH + +G+ E G+G V+W GH++EQ QP YD R+ + Sbjct: 1 MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDGY-VSWLAGHVMEQVQPGDYDERWGK 59 Query: 61 --WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W+L+ Q+ +I+ L + + IV+ GD DREGQLLVDEVL + Sbjct: 60 FPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLH 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V R ++ ++P +V++AI L N+ F PL + L R RADWL G+NM+R Sbjct: 120 FG----NTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE--RF 236 AYTIL + Y GVLSVGRVQ+P L LVV+RD EI+ FV KDF+ V+A P F Sbjct: 176 AYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPF 235 Query: 237 TAIWQP------------------------------------SEACEPYQDEEGRLLHRP 260 + W P + + DE+ R++++ Sbjct: 236 WSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKA 295 Query: 261 LAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKL 319 +A+ + + VT Y +K E PLPF L+ LQ ++G SA+ VLD CQ+L Sbjct: 296 VADQIAANVQAAGQGTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQEL 355 Query: 320 YETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP-QPVVDPDIRNRCWDDKKV 378 Y TYPRSDC YLP A V++AI+ AP L + IR+R W+D KV Sbjct: 356 Y-LQGHTTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDSKV 414 Query: 379 DAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAK 437 HHA+IPT ++ +TE + + Y +IA++YL Q P+ K +E+ IA +F A Sbjct: 415 TEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFAAS 474 Query: 438 ARFLAEAGWRTLL-----GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFT 492 R + + GWR + + + ++ LPV+ + + V ++T PP +T Sbjct: 475 GRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPRYT 534 Query: 493 DATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTD 552 + +LL+AM + R V D +K L+A DG+G ATRAGIIE++ KRGF+ KG+ + +T Sbjct: 535 EGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVATV 594 Query: 553 AGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 GK L +LP T P MTA WE++L I++KQ FM + +L+ A+ + + Sbjct: 595 VGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAARVSTLP 654 Query: 613 QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 P P AKK P + Sbjct: 655 TIPPDAMPARKPYTGSSTPRPAPDGAKKCPKCKKG 689 >UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C314B9 Length = 754 Score = 587 bits (1513), Expect = e-166, Method: Composition-based stats. Identities = 205/640 (32%), Positives = 333/640 (52%), Gaps = 28/640 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+ R ++ VL P R+G+GF+E G ++TW +GHL++ A+PD YD ++ RW Sbjct: 5 LVIAEKPSVGRDLSRVLAGPFRRGEGFLE-GPDHILTWAVGHLVQLAEPDEYDDKFKRWR 63 Query: 63 LADLPIVPEKWQLQPRPSVTK-QLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 +ADLPIVPEK++L R +K Q+NV+KR L +V+A D REG+L+ YL Sbjct: 64 MADLPIVPEKFRLVVRDERSKRQMNVVKRQLGRDDIGVVVNACDAGREGELIF----AYL 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR ++ + A+ A +LR +E L +A +R+ ADW+ G+N TRA Sbjct: 120 YEKAGSRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDAARSRSEADWIVGMNSTRA 179 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 TI R++ + G +S+GRVQTP L ++ RR+EEI F + ++ V A + + Sbjct: 180 ATIRLRSS-FDGAVSLGRVQTPTLAILARREEEIRAFRPEPYWTVDATFAASGERVYDGR 238 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + + R+ A VV G ++T ++ E PL + L++LQ Sbjct: 239 FHVTAGSGDGRG--PRIGSAEFAAAVVEACRGTDGVITKLEKRKRRERVPLLYDLTSLQR 296 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A RFG SA+ L Q+LYE HK +TYPR+ RYLP + + + + Sbjct: 297 DANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEIKPIAEIVGGRSEYAA 356 Query: 360 PQPVV---DPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 V D R +D +V HHAIIPT ++ + +++ ++Y+L+A+++L F Sbjct: 357 GARYVLGLDVLPLARVVNDARVTDHHAIIPTRAPHPVDRMGDDDRRIYDLVAKRFLAVFH 416 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE-------NDGTPLPVVA 468 PDA F +E ++A F + + + GWR + G E LP + Sbjct: 417 PDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYGESADAEPREGEEDEGREQQLPKLE 476 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+++ + +++T+PPR +++ +LL+AM + V +++L++ ++ + G+GT ATR Sbjct: 477 QGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEEELREAMKDS-GIGTPATR 535 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQCR 587 A IIE L G++ + GR + T+ G + L T P +T WE L +I + Sbjct: 536 AAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGHPLTSPSLTGDWEHRLGKIELNEDS 595 Query: 588 YQDFMQPLVGTLYQLIDQ--AKRTPVRQFRG--IVAPGSG 623 + FM +V + + AK VR R P G Sbjct: 596 RRAFMADIVKFAESTVAELDAKLRDVRIPRANLGPCPVCG 635 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 587 bits (1513), Expect = e-166, Method: Composition-based stats. Identities = 248/659 (37%), Positives = 371/659 (56%), Gaps = 23/659 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ I VL + DG+ + G+ +VTW GH+L QA PDAY +YA Sbjct: 1 MRLFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGD-TIVTWAFGHILTQAAPDAYGEQYAD 59 Query: 61 W-NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + N++ LPI+PE WQ+Q P V+KQ VIK L +A E+V A D DREG+++ E+LDY Sbjct: 60 FGNISALPILPEVWQMQVPPKVSKQFKVIKSLLAKADEVVIATDADREGEVIAREILDYC 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R+++ R + L+ Q+V++A+ + + L + LAR RADWL G+N++RA Sbjct: 120 G----YRKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLARGRADWLVGMNLSRA 175 Query: 180 YTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT G + +LS+GR+QTP L LVV+RD+EI+ FV +++ + T FT Sbjct: 176 YTAAYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTLSVDFETADKSVFTT 235 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +WQ E +++ +G + + +V ++ V + N +R+S PLP+SLSALQ Sbjct: 236 LWQVPEN---WRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTPPPLPYSLSALQ 292 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA K+ GLSA VL I Q LYE +K+ +YPR+ CRYLP+ + V AI + Sbjct: 293 KEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDVFAAIQTIDKSM 352 Query: 359 LPQ-PVVDPDIRNRCWDDKKVD--AHHAIIPTARSSA--INLTENEAKVYNLIARQYLMQ 413 L DP+ ++R W+D +V+ +HHAIIPT S+ L +NE VY +I +Y+ Q Sbjct: 353 LSVIEKADPERQSRVWNDNQVNKHSHHAIIPTKASNFDLSVLDKNELTVYRMIRDRYIAQ 412 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK--ERDEENDGTPLPVVAKGD 471 F PD + V+E++ F A ++ +GW+ LLG E D+ ++G LP + D Sbjct: 413 FYPDFEYDSTVVEVEACSHLFKASSQSPVISGWKVLLGKDVFEGDQIDEGPALPHLKVND 472 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF---VQDKDLKKILRATDGLGTEATR 528 E+ ++T PP FT+A+LL M + F V+D+ ++KIL++T+GLGTEATR Sbjct: 473 EVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRKILKSTEGLGTEATR 532 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A II+ LF+ G++ KK I++T+ G+ L +P M P TA WE L I + Sbjct: 533 ATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTMIADPITTAKWELALAGIEAGKLTL 592 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 +FM + +L+ QAK+ V + R P SA KK A + P E Sbjct: 593 AEFMAYQQKVITELVGQAKKDAVGKAR---PPKQTDSAGTKKQAVARNEDDVCPTCKEG 648 >UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_9BACT Length = 817 Score = 586 bits (1512), Expect = e-166, Method: Composition-based stats. Identities = 198/668 (29%), Positives = 317/668 (47%), Gaps = 71/668 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L ++G GF+E GNG VTW GH++E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHLGAT-KRGVGFLE-GNGWAVTWAFGHMVELQEPEDYKPEWKA 58 Query: 61 WNLADLPIVPEKWQLQPRPS-----VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L+ LPI+P + L+PR S QL IK+ +A EI+ A D REG+L+ + Sbjct: 59 WRLSTLPIIPADFALRPRASDPDGTARAQLETIKKLFLDADEIICATDAGREGELIFRYI 118 Query: 116 LDYLQL---APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 + P + V+R I+ L +A+E+ L S++ L +A R+ ADW+ Sbjct: 119 YTWTGCEALPPPLAKPVRRLWISSLTNEAIEKGFQNLAPGSDYDRLYHAARCRSEADWIV 178 Query: 173 GINMTRAYTI-LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N TR +T+ GR +LS+GRVQTP+L ++V RD ++E+F +DF+EV Sbjct: 179 GLNATRFFTVEYGRR---NLLLSLGRVQTPILAMIVGRDLDVEHFKPEDFWEVHTLC--- 232 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 ++ G+ + A+ +V+RI+G ++ + K PL Sbjct: 233 -------------RSATFKHTAGKFTVQTEAQAIVDRITGHELVIKNVTKKNALTHPPLL 279 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 + L+ LQ + KR GL+A L + Q LYE+ L TYPR+D YL + +++ + Sbjct: 280 YDLTGLQRDMNKRHGLTADQTLRLAQSLYESKHL-TYPRTDSCYLSTDIQPTIGPLLDRL 338 Query: 352 SVHAPDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 P + + R DDKKV HHAIIPT +LT +EAKVY+ + + Sbjct: 339 RALKPAEIGKLDTGALAFSKRIIDDKKVSDHHAIIPT-NVLGGDLTGDEAKVYDAVLTRL 397 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE------------ 458 + F P + +E + A F A+ L + GW+ L G D++ Sbjct: 398 IAVFYPPCIKAVTTVEAESAGEPFRARGTVLVDPGWQALYGGDVSDDDAGTGTKAKKASK 457 Query: 459 -----------------------NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDAT 495 + LP +G+ + + + +T P+ F +A+ Sbjct: 458 NAAKKDADENESGESDAKDSDAADSAQQLPDFQEGER-NPHEPSLPQFKTSAPKRFNEAS 516 Query: 496 LLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGK 555 LL M + V D+ LK+ L+ G+GT ATRA IIE+L RG++ +K + + STD+G+ Sbjct: 517 LLQLMETAGKIVTDETLKEALKD-KGVGTPATRAAIIEVLITRGYVERKKKNLISTDSGR 575 Query: 556 ALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF 614 AL + E P++T WE L QI + + FM + +++ + Sbjct: 576 ALISLVQDERLKSPELTGDWEYRLRQIERGEYEPRVFMSEVEAYTREILKNRAEQTINLS 635 Query: 615 RGIVAPGS 622 P Sbjct: 636 NLGPCPAC 643 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 585 bits (1509), Expect = e-165, Method: Composition-based stats. Identities = 210/640 (32%), Positives = 325/640 (50%), Gaps = 35/640 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-ARW 61 L IAEKPS+AR +A VL R GDGF++ G G +VTW +GHL+ A+P + + RW Sbjct: 5 LIIAEKPSVARELAGVLGVKGR-GDGFLQ-GPGHIVTWAVGHLVNIAEPAEQNPAWSGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYL 119 ++ LP++P ++ L PS KQ +I+ FL + +V+A D REG+L+ + Sbjct: 63 SMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIY--- 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L + ++R ND+ + +++A + S E L +A ARA ADWL G+N +R Sbjct: 120 -LLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ +++VGRVQTPVL L+V R EIENF+ +D++ V+ E F A Sbjct: 179 FTLRA-----GSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEG-ETFKAT 232 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + ++ ++ + VV +G+ V K+ + PL F L+ LQ Sbjct: 233 WFAAPDF-----KDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQK 287 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL- 358 EA R G SAQ L I Q LYE KLITYPR+D RYL +E FA M A+ H P++ Sbjct: 288 EANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEIS 347 Query: 359 --LPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFC 415 + D + C +DKKV HHAIIPT R++ L + E +Y +I R++ F Sbjct: 348 QSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFM 407 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 DA F + + + ++ A + + GW + ++ PLP + KG + Sbjct: 408 DDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRA----SEDNPLPNLRKGAAVTA 463 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 + ++V +T+PP HFTDATLL+AM + + D++L+ ++ GLGT ATRA IIE L Sbjct: 464 QSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKE-RGLGTPATRAQIIETL 522 Query: 536 FKRGFLTKKGRYIHSTDAG---KALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 R ++ K G+ + +TD G + S+ P++T WE L ++ + Y FM Sbjct: 523 LARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFM 582 Query: 593 QPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 + + + + K R P K+ Sbjct: 583 HQVREMVSSGVSRVK---GSNARPPACPVVSDRKPSKEVN 619 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 584 bits (1506), Expect = e-165, Method: Composition-based stats. Identities = 212/645 (32%), Positives = 329/645 (51%), Gaps = 34/645 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A IA L K D + E + V++ +GHLLE A P+ Y+ + +W+ Sbjct: 27 LIIAEKPSVANDIARALGG-FTKHDEYFES-DDFVLSSAVGHLLEIAAPEEYEVKRGKWS 84 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 A+LP++P + L P +L V+ + + + +++A D REG+L+ + + + Sbjct: 85 FANLPVIPPHFDLNPIAKSESRLKVLNKLIKRKDVDRLINACDAGREGELIFRLIAQHAK 144 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 +Q VQR + + P A+ +LR+++E PL +A R+ ADWL GIN TRA Sbjct: 145 ----AKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARCRSEADWLVGINGTRAM 200 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T G + +VGRVQTP L +VV R+E+I FV +D++EVKA V + + Sbjct: 201 TAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCASGFYEGRWY 260 Query: 241 QPSEACEPYQDEE--GRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P + + E+ RL P AE +V GQ VT K ++ +P F L++LQ Sbjct: 261 DPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTE-ESKPSTQLSPALFDLTSLQ 319 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV----- 353 EA RFG SA+N L + Q LYE HK++TYPR+D R LPE++ M + Sbjct: 320 REANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLETVKHTMEMLKESNNYL 379 Query: 354 -HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 HA +L + V P+ R +D+ K+ H AIIPT ++ L+E E K+Y+L+ +++L Sbjct: 380 PHAKQVLDKGWVKPN--KRIFDNSKISDHFAIIPTLQAPKA-LSEPEQKLYDLVVKRFLA 436 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P A +R ++ F + + L E GW + G + E+ + L V K ++ Sbjct: 437 VFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRETGGEDAN---LVPVQKDEK 493 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + T+PP + +ATLLSAM G + V+D +L++ + A GLGT ATRA II Sbjct: 494 VKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAM-AAKGLGTPATRAAII 552 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRY 588 E L +L ++GR + T L L + T P++T WE L+Q+ + Sbjct: 553 EGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGEWEYKLSQMERGKLPR 612 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGGSAD 627 FMQ + ++ +AK G P GG Sbjct: 613 DAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVK 657 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 583 bits (1504), Expect = e-165, Method: Composition-based stats. Identities = 211/687 (30%), Positives = 332/687 (48%), Gaps = 52/687 (7%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA VL H+ G IE G+ +VTW +GHL+ A P+ YD ++ Sbjct: 1 MKSLVLAEKPSVARDIARVLG-CHKNISGAIE-GSNYIVTWALGHLVTLADPEEYDKKFK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 W+++ LP+VP+KW+L +KQ + +K L + SEI+ A D REG+L+ +LD Sbjct: 59 AWDMSYLPMVPKKWELVVIKQTSKQYHNVKTQLFRKDVSEIIIATDAGREGELVARWILD 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++R I+ + +A++ L+ + L +A +RA ADWL GIN T Sbjct: 119 KSGCH----KPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARSRAEADWLVGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS GRVQTP L ++ R+++I +F +D++ ++ T Sbjct: 175 RALTC-----KYNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTSVTGGSVGT 229 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + + R ++ L + ++ Q VT + + +P + L+ L Sbjct: 230 MASIVTWTWQQKKSGSLRSFNKDLITGLDKKLKNQTLTVTDVHTSSKRTPSPGLYDLTEL 289 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH-AP 356 Q +A KRFG SA+ L+I Q LYE HK++TYPR+D RY+ + + A ++ Sbjct: 290 QRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKERLKACNIGPYK 349 Query: 357 DLLPQPVVDPDIRNRCW-DDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 +P+ + P ++ + DDKKV HHAIIPT + ++ NE K+Y+L+ R+++ Sbjct: 350 KYIPELLKKPLKTSKAFVDDKKVSDHHAIIPTEEYVQMEHMSNNERKIYDLVVRRFISVL 409 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL----------------LGSKERDEE 458 P + + ++ + A F AK + + AGW+ + G E E+ Sbjct: 410 YPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSASQYDAYGDYEDSED 469 Query: 459 -------------NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 LPV+ KGD L + + +T+ P FT+ATLLSAM R Sbjct: 470 FGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARFTEATLLSAMENPVR 529 Query: 506 FV--QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE 563 ++ D +KK L T GLGT ATRA IIE LF L KKG I T GK L +PE Sbjct: 530 YMSSDDNKMKKTLGETGGLGTVATRADIIEKLFHSFLLEKKGNEILLTSKGKQLLELVPE 589 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR----QFRGIVA 619 +P++TA WE L +I++ + Q F++ + +LI K + Sbjct: 590 DLKKPELTASWEMELAKIAKGAHKEQVFIKDIESYTKELIQDIKTSDGTFRHDNLTNTKC 649 Query: 620 PGSGGSADKKKAAPRKRSAKKSPPADE 646 P G K + + Sbjct: 650 PHCGKRMLSVKGKNSRMLVCQDRECGY 676 >UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organisms RepID=A5FHK0_FLAJ1 Length = 768 Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats. Identities = 192/650 (29%), Positives = 327/650 (50%), Gaps = 33/650 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA VL + K DG+ E GNG VT+ GHL +P+ Y + Sbjct: 1 MKVCIAEKPSVAREIASVLG-ANTKHDGYYE-GNGYAVTYTFGHLCTLKEPNDYKPHWKS 58 Query: 61 WNLADLPIVPEKWQLQP--RPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L +LP++PEK++ + + KQ +IK +A +++ GD +EG+L+ V++ Sbjct: 59 WDLNNLPMLPEKFETKVVQNSGIQKQFKIIKTLFDKAELVINCGDAGQEGELIQRWVMNE 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + +++R I+ L +A++ D L+ + + L + +RA DWL G+N TR Sbjct: 119 AH----YKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAIGDWLLGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ ++ GY+ VLS+GRVQTP L +VV R +EIENF + ++E++ Sbjct: 175 LYTV--KHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQTLY---------- 222 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + EEGR L + E + ++ + S + K +E AP F L+ LQ Sbjct: 223 ------RETLFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLTGLQ 276 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++FG SA+ L I Q LYE K ITYPR D +LP + + ++ ++ ++ Sbjct: 277 VYCNQKFGFSAEETLKIAQTLYE-QKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSHLT 335 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 P + ++DKKV HHAIIPT INL N+ +VY++I +++L F D Sbjct: 336 EPLLGKKIKKSPKVFNDKKVTDHHAIIPTGI--EINLPYNQQQVYDIIVKRFLAVFYDDC 393 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + + A F A + + + G+R + +E + LP G++ + Sbjct: 394 LVANTTVIGKAADVTFKATGKEILKKGFRVVF-EDPNAKEKEPDLLPSFVVGEKG-PHEP 451 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 ++++T+PP HFT+ATLL AM + V D+DL+++++ +G+G +TRA IIE LFKR Sbjct: 452 SFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKE-NGIGRPSTRANIIETLFKR 510 Query: 539 GFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVG 597 ++ + + + T G L ++ E+ ++T WE L I + F++ + Sbjct: 511 QYIVRNKKQVLPTTTGIQLIDTIQNELIKSAELTGSWEKQLKDIEKGTFTAAAFIRNMKR 570 Query: 598 TLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 + L+ + + A + +K A+ P + Sbjct: 571 MVEALVTEVRSETRHANISHAATIQKPAVKAEKKKAAGILAETCPKCQKG 620 >UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria RepID=A4JFS2_BURVG Length = 760 Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats. Identities = 237/629 (37%), Positives = 360/629 (57%), Gaps = 24/629 (3%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG----QVVTWCIGHLLEQAQPDAYDSR 57 RLFIAEKP++AR IA + K G++E G +V CIGHLL+QA+P Y Sbjct: 3 RLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYVKD 62 Query: 58 YA-RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 ADLPI+P++W+LQ + Q+ +++R L E E+V+AGDP REGQL++DE+L Sbjct: 63 LEFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDELL 122 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 ++ R+ V+R L+N L+ V+R + L+ N+ F P+ + L R RADWL G+N+ Sbjct: 123 EFCG----NRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGMNL 178 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RAYTILGR A Y+GVLSVGRVQ+P L LVVRRD IE FV +D++ VKA + E F Sbjct: 179 SRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGE-F 237 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A W+ E + DEEGR++ + AE +V GQ +T + K E LPFSL+ Sbjct: 238 WARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSLAT 297 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQI A+ ++G SA+ VLD CQ LY K +YPR+D R+L A ++AI+ Sbjct: 298 LQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQTLS 357 Query: 357 DLLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQF 414 L P D I + WDD KV H+A+IPT+ ++ +LT + +Y +A++Y+ F Sbjct: 358 MLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYITLF 417 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------------GSKERDEENDGT 462 PD + + +E +A+ F A R + GWR + K +E+ D Sbjct: 418 YPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKEDEQ 477 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 P ++ G + +++T+PP +D++LL AMT + + V+D L++ L+++ G+ Sbjct: 478 RFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSKGI 537 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQIS 582 GT ATRA IIE L ++G L ++G+ + S+ A + L +LP P ++A WE+ L ++ Sbjct: 538 GTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDLVA 597 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 + FMQ L QL+++A+ T + Sbjct: 598 AGKAPLDLFMQKQEAWLRQLLEKAQATGL 626 >UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE Length = 694 Score = 582 bits (1500), Expect = e-164, Method: Composition-based stats. Identities = 250/658 (37%), Positives = 365/658 (55%), Gaps = 33/658 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 MRLFIAEKPS+A+AIA L + KGDGFIECG VTWC GH+LEQA+PD Y Sbjct: 1 MRLFIAEKPSVAKAIASELGQSG-KGDGFIECGTD-TVTWCFGHMLEQAEPDEYTPDDVP 58 Query: 59 ------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 W + +LPI+P W L+ + +QL VI + L EA+EIV+A DPDREGQLLV Sbjct: 59 RNARGKKIWRVDELPIIPTDWMLKAKDDAKQQLAVIGKLLKEAAEIVNAADPDREGQLLV 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL++ + + +R ++ + +V+R + L+ N + +A AR RADWL Sbjct: 119 DEVLEHFRC----NKPARRFWVSAQDSVSVKRGLAALKDNGTYHGWADAARARQRADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N++RAYT+ + G +G+L+VGRVQTP L LVV RD EIE F + ++A I Sbjct: 175 GMNLSRAYTLRAQRGGSRGLLTVGRVQTPTLTLVVARDREIEAFKPIPYHTIRAAIQHSG 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 F A W+ ++ + D EGRL+ +A+ +V +++G+P V Y + + ++ PL F Sbjct: 235 -GAFLASWR-AKVDQAGLDAEGRLVDTAVADALVAKVTGKPGTVAEYTQEAKKQNQPLAF 292 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS + + A+ +FG SA++VL+ CQ LYETHKL +YPR+DC YLPE A V+ AI Sbjct: 293 ALSDITLLASNKFGYSAEDVLNACQTLYETHKLTSYPRTDCAYLPESQHADSPRVLKAIQ 352 Query: 353 VHAPDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQY 410 P+L DP ++++ W+D K+ AHH IIPT + S L E E +Y+LI R Y Sbjct: 353 HVNPELAGLVAGADPRLKSKTWNDSKITAHHGIIPTMHNGSKAGLIERERNIYDLIVRAY 412 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-KERDEEND-----GTPL 464 L QF + + +++ FVA + + GWR + E+D E D L Sbjct: 413 LAQFYCVHEYMSTTVVVEVEDETFVATGKVVTRNGWRDVYQEVDEQDTEKDADEGGNQRL 472 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + KGD + C++ + +T+PP FT+ TLL AM I + V + + KK+LR DG+GT Sbjct: 473 PAMQKGDGVTCKQATRKDAKTKPPARFTEGTLLRAMENIHKVVPEPEHKKMLREEDGIGT 532 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 ATRA II L +RGFL KG+ I T G+++ +LPE+ P +TA +E +L I + Sbjct: 533 SATRASIISELKRRGFLETKGKQIIGTTLGRSMIDALPEVVKSPVLTALYERMLKGIEQG 592 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG---------IVAPGSGGSADKKKAAP 633 F+ + + +A V G G ++ Sbjct: 593 TAELAAFIAKQETFIRDQVTKANDGAVAIAGGREALPISTLYKCMACGQGLIRRPTKK 650 >UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_9BACT Length = 781 Score = 581 bits (1498), Expect = e-164, Method: Composition-based stats. Identities = 200/646 (30%), Positives = 321/646 (49%), Gaps = 41/646 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L K ++ DG++E GNG VTW GHL+E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHL-KAGQRHDGYLE-GNGWAVTWAFGHLVELKEPEEYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W ++ LPIVP++++L+ R KQL +K+ EA EI+ A D REG+L+ +L++ Sbjct: 59 WKVSLLPIVPDQFELRARGDDGAKKQLETVKKLFGEAEEIICATDAGREGELIFRYILEW 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R I+ L A+ + +LR +F L +A R+ ADW+ G+N TR Sbjct: 119 SGCEA---KPVKRLWISSLTGAAISKGFAKLREGKDFDTLHYAARCRSEADWIVGMNATR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +T+ +LS+GRVQTP+L ++V RD EIENF ++DF+E+ Sbjct: 176 YFTV--EYGKRNLLLSLGRVQTPILAMIVGRDMEIENFKSEDFWELHTEC---------- 223 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 ++ G++ A+ + ++ GQP +V+ K E+ + PL F L+ LQ Sbjct: 224 ------RDTKFRHTGGKIQKEEEAKALFEKVDGQPLVVSDVQQKNENTNPPLLFDLTELQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA-PD 357 E +R+G +A L I Q LYE K ITYPR+D RYL + ++ + + Sbjct: 278 REMNRRYGFTADQTLRIAQNLYE-QKRITYPRTDSRYLSTDLQPTIGPLLERLKAIKEKE 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 + P + R DD KV HHAIIPT NL +E +VY+ I + + F P Sbjct: 337 IAPLELDKLSFGKRIVDDSKVSDHHAIIPTDDLPR-NLNADEERVYDAILVRLIAVFYPA 395 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----------SKERDEENDGTPLPVV 467 V +E ++ F A+ L EAGW+ L + + +P Sbjct: 396 CVKAVTTVEAKASEETFRARGTVLLEAGWQALYPQLFAIASKKKGAKGKAAPEPAAMPHF 455 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G+ + + + +T PP+ FT+ATLLS M + V+D++LK+ L+ G+GT AT Sbjct: 456 QVGES-NPHRPSIEKFKTNPPKRFTEATLLSLMETAGKIVEDEELKEALKD-KGVGTPAT 513 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQC 586 RA IIE+L +R ++ +K + + ST +G+ L + E P++T WE L ++ + Sbjct: 514 RASIIEVLIQRKYVERKKKNLISTYSGRHLISLIQDERLKSPELTGDWEFRLKKVERGEQ 573 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 + FM +V +++ V P + Sbjct: 574 DPKAFMSDVVEYTKEILANDAEKTVDLKNLGPCPKCSAPVMRGNTG 619 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 580 bits (1494), Expect = e-164, Method: Composition-based stats. Identities = 204/672 (30%), Positives = 317/672 (47%), Gaps = 65/672 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+A+ IA VL K ++E G VVTW +GHL+ A+P+ YD +Y Sbjct: 1 MKSLVLAEKPSVAKEIARVLG-CSSKNKSYME-GPDYVVTWALGHLVTLAEPEDYDPKYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 WNL DLP++P K L+ + Q + + E++ A D REG+L+ +++ Sbjct: 59 TWNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIATDAGREGELVARWIME 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + R+ +R I+ +A++ L+ ++ L SA+ RA ADWL G+N+T Sbjct: 119 LVHW----RKPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVCRAEADWLIGLNVT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y L+ GRVQTP LG ++ R++EI F ++ ++ V A + F Sbjct: 175 RALTV-----KYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAEL-----GAFQ 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A+W+ ++ + +GR+ R AE V+ R+ G+ A V ++SE P F L+ L Sbjct: 225 ALWRQND------NHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLTEL 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN--AISVHA 355 Q EA KR G SA+ ++ QKLYE HKL+TYPR+D RYL + + A+ +A Sbjct: 279 QREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGPYA 338 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQF 414 P + R DD KV HHAIIPT + L+ +E K+Y+LI R+++ F Sbjct: 339 PLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYVNLSALSNDERKLYDLIVRRFIALF 398 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-------KERDEENDG------ 461 P + + + L + + K AK + + GW+ L G E DEE +G Sbjct: 399 YPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGRGEDKS 458 Query: 462 ---TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 LP + +G + ++ + E +T PP +T+A+LLS M Sbjct: 459 TPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEK---------------- 502 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 GLGT ATRA IIE L + + + T GK L + + P++TA WE L Sbjct: 503 -HGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVDELRSPELTAKWEREL 561 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLI----DQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 I+ Q + FM + + + ++ K P G + K Sbjct: 562 ELIAHGQGDAKRFMAGIREQANKWVTAVKNETKEYKPHNLTHSRCPECGKLLMEVKGKRG 621 Query: 635 KRSAKKSPPADE 646 K Sbjct: 622 KSLVCSDRECSY 633 >UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bacteroides RepID=B7AD12_9BACE Length = 729 Score = 580 bits (1494), Expect = e-164, Method: Composition-based stats. Identities = 212/680 (31%), Positives = 338/680 (49%), Gaps = 54/680 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IADVL K DG+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIADVLG-ARDKRDGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKW--QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L LP+VP ++ +L P+ +Q +VI+ + A I++ GD +EG+L+ V+ Sbjct: 59 WSLGSLPMVPPRFGIKLISNPTYERQFHVIENLMQHADMIINCGDAGQEGELIQRWVMQK 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 R V+R I+ L +A+ +LR S+F PL + L+RA DWL G+N TR Sbjct: 119 AG----ARCPVKRLWISSLTEEAIREGFAKLRDASDFQPLYEAGLSRAIGDWLLGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ + + VLS+GRVQTP L L+V R EI+NFV K ++E+K D F+A Sbjct: 175 LYTM--KYGQNRQVLSIGRVQTPTLALIVNRQLEIQNFVPKQYWELK---TVYRDTTFSA 229 Query: 239 IWQPSEACEPYQDEEGR------------------LLHRPLAEHVVNRISGQPAIVTSYN 280 I + S+ + E+ + + R ++ +I P +T+ Sbjct: 230 ILRKSDEELVLEAEKQKEGAAAKAAKPEENRGIEPITDRERGTALLEQIRNAPFTITNVT 289 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K E+ F L++LQ+E K+F SA L Q LYE K+ TYPR D +L ++ Sbjct: 290 RKNGKEAPLRLFDLTSLQVECNKKFAFSADETLKTIQSLYE-KKVTTYPRVDTTFLSDDI 348 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA 400 + ++ + + P + +D+ KV HHAIIPT + NLT+ E Sbjct: 349 YPKCPGILKGLRDYQALTAPLEGTTLLKSKKVFDNSKVTDHHAIIPTGQPPQ-NLTDMER 407 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 +V++LIAR+++ F PD +F + ++ + +F + + E GWR + G+ + + Sbjct: 408 RVFDLIARRFIAVFYPDCLFATTTVIGEVEQIEFKVSGKQILEPGWRVVFGTPSAQSQEE 467 Query: 461 G--------TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDL 512 LP G+ ++ E+ TQPPR +T+ATLL AM + V + +L Sbjct: 468 KDEKGGEEENVLPAFVVGESG-PHLPDLYEKWTQPPRPYTEATLLRAMETAGKLVDNDEL 526 Query: 513 KKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMT 571 + L+ +G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ ++T Sbjct: 527 RDALKE-NGIGRPSTRAAIIETLFKRNYIRKEKKNLIATPTGVELIQIIHEELLKSAELT 585 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA--KRTPVRQFRGIVAPGSGGS---- 625 WE L +I ++ F++ L + +++ + AP GG Sbjct: 586 GIWEKKLREIEKRTYNAGQFLEELKQMVSEIVMSVLSDNSNRHITIQAPAPEKGGKNSAS 645 Query: 626 ----ADKKKAAPRKRSAKKS 641 +DK K P+KR+ +KS Sbjct: 646 SASASDKPKKEPKKRAPRKS 665 >UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales RepID=C3QFV7_9BACE Length = 725 Score = 579 bits (1493), Expect = e-163, Method: Composition-based stats. Identities = 208/624 (33%), Positives = 329/624 (52%), Gaps = 36/624 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IA+VL RK +G+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIAEVLGAHTRK-EGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKWQLQPR---PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W+L+ LP++P ++ ++ P + KQ +VI+ + A EI++ GD +EG+L+ V+ Sbjct: 59 WSLSSLPMIPPRFGIKLIGHDPGIEKQFHVIEWLMQNADEIINCGDAGQEGELIQRWVMQ 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 R V+R I+ L +A+ +L+ +EF L + L+RA DWL G+N T Sbjct: 119 KAG----ARCPVKRLWISSLTEEAIREGFSKLKDQAEFQSLYEAGLSRAMGDWLLGMNAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R YT+ + + VLS+GRVQTP L L+V R EI NF K ++E+K + F+ Sbjct: 175 RLYTL--KYGQNKQVLSIGRVQTPTLALIVNRQLEIANFEPKQYWELKTNYRNT---TFS 229 Query: 238 AIWQPSEACEPYQDEEG------------RLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 A+ + S+ ++E+ + +R E +V RI P +VT+ K Sbjct: 230 ALIRKSDEEIAAEEEKNGGKKKIDNPGIDPIANREEGEALVERIKDLPFVVTNVGKKDGK 289 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 E AP F L++LQ+E K+F SA L + Q LYE K+ TYPR D +L ++ + Sbjct: 290 EYAPRLFDLTSLQVECNKKFAYSADETLKLIQSLYE-KKVATYPRVDTTFLSDDIYPKCP 348 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 A++ + + P + +D+ KV HHAIIPT A NLT+ E +VY+L Sbjct: 349 AILKGLRDYEVLTAPLAGTTLLKSKKVFDNSKVTDHHAIIPTG-VYAQNLTDMERRVYDL 407 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-----EEND 460 IAR+++ F PD + ++ K +F + + E GWR + + +D EE D Sbjct: 408 IARRFIAVFYPDCKISTTTVMGEVDKIEFRVTGKQILEPGWRVVFAKEVKDPTEEKEEED 467 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP KG+ ++ E+ TQPPR +T+ATLL AM + V + +L+ L+ + Sbjct: 468 ENVLPAFVKGESG-PHIPDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDELRDALKE-N 525 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLT 579 G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ ++T WE L Sbjct: 526 GIGRPSTRAAIIETLFKRNYIRKERKNLIATPTGVELVQLIHEELLKSAELTGIWEKKLR 585 Query: 580 QISEKQCRYQDFMQPLVGTLYQLI 603 +I +K + F++ L + +++ Sbjct: 586 EIEKKTYDARQFLEELKQMVSEIV 609 >UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q01NZ0_SOLUE Length = 1333 Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats. Identities = 198/628 (31%), Positives = 309/628 (49%), Gaps = 37/628 (5%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKPS+AR IA VL KG+GF+ GNG VVTW IGHL AQP D ++ W Sbjct: 11 VLAEKPSVARDIARVLGAGT-KGEGFLH-GNGYVVTWAIGHLAALAQPGEIDPQWRPWRR 68 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQL 121 LP++P +W L Q +KR L+ +V A D REG+L+ + + Sbjct: 69 NTLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVCATDAGREGELIFRYIYEAAGC 128 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + V R I+ L P A+ + D LR +++ L +A R+RADWL G+N++RAY+ Sbjct: 129 ----EKPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAARGRSRADWLVGMNLSRAYS 184 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER---FTA 238 + Y LSVGRVQTP L ++V R+ + NFV +D+ EV A + + Sbjct: 185 LA-----YSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATFHPTGAPKESVYQG 239 Query: 239 IWQPSEACEPYQDEEGRLL----HRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 W ++ + + + A + R A + S + + + + P + L Sbjct: 240 TWFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESIDAQTQRMAPPPLYDL 299 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + LQ A + FG SAQ LD Q LYE HKLI+YPR+D R+L ++ V+ AI+ Sbjct: 300 TELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVARTLPRVVAAIAEP 359 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQ 413 +LL + + R DD KV HHAIIPT S+A L +E K+Y+LI R+ L Sbjct: 360 YRELLAPGTGERPLGRRFVDDAKVTDHHAIIPTVTSAANAQLAPDERKIYDLICRRLLSA 419 Query: 414 FCPDAVFRKCVIELDIAK----GKFVAKARFLAEAGWRTLLGSKER----------DEEN 459 + D ++ + I ++ + + + GW+ L + + D + Sbjct: 420 WHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAPAKAKRAKSPGTADADR 479 Query: 460 DGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 LP +A G E ++++T+ P+ FT+ TLL+AM + + +K+L ++ Sbjct: 480 GEQELPPGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMETAGKTLDEKELSDAMKE 539 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 T GLGT ATRA IIE+L KR ++ + G+ + +TD G L + P MT WE+ L Sbjct: 540 T-GLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVHPEVRSPIMTGQWEAYL 598 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQA 606 +I + FM + + ++ + Sbjct: 599 HRIHRGNAQLDPFMHGIEEYVRDVVGKV 626 >UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q21RE9_RHOFD Length = 1017 Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats. Identities = 213/691 (30%), Positives = 335/691 (48%), Gaps = 49/691 (7%) Query: 1 MR-LFIAEKPSLARAIADVL---PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS 56 M+ L IAEKPS+A+ I L K D E + VVT +GHLLE P+ +D Sbjct: 16 MKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFES-DSYVVTSAVGHLLEIQAPEEFDV 74 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 + +W+ A LP++P + L+P +LN + + + ++++A D REG+L+ Sbjct: 75 KRGKWSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRL 134 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + Y A + V+R + + PQA+ + LRSN + +PL +A R+ ADWL GI Sbjct: 135 IEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGI 194 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N TRA T G + +VGRVQTP L +VV R+E+I FV++D++EV A A + Sbjct: 195 NGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGD 254 Query: 235 R----FTAIWQPSEACEPYQD--------EEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 F W+ + A + + RL + A+ + + + GQ A VT K Sbjct: 255 YPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAIADAVRGQTASVTE-ESK 313 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 ++++PL F L++LQ EA +FG SA+ L I Q LYE HK +TYPR+D R LPE++ Sbjct: 314 PTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLP 373 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRN------RCWDDKKVDAHHAIIPTARSSAINLT 396 +S A L + N R +D+ KV H AIIPT ++ + L+ Sbjct: 374 VVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVSDHFAIIPTLQAPS-GLS 432 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 E E K+Y+L+ R+++ F P+A ++ A F + + L + GW + G + D Sbjct: 433 EAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVD 492 Query: 457 EEND---------GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 E D G L V G+ + + E +T+PP +T+ATLL AM G + + Sbjct: 493 EVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTI 552 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----E 563 +D +L+ + GLGT ATRA IIE L + ++ ++GR + T + L L + Sbjct: 553 EDDELRAAMHE-KGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVK 611 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG------I 617 ++ ++T WE L + Q +FM + +++ QAK G Sbjct: 612 ELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAKEYDRDTVPGNYATLTA 671 Query: 618 VAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 P GG K+ R K+ + G Sbjct: 672 PCPNCGG--IIKENYRRYTCTGKTGAEEGCG 700 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats. Identities = 198/648 (30%), Positives = 333/648 (51%), Gaps = 33/648 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + IAEKPS+AR IA VL K +KG+G++E G+ +VTW +GHL+ A P++YD +Y +WN Sbjct: 5 VVIAEKPSVARDIARVL-KCDKKGNGYLE-GSKYIVTWALGHLVTLADPESYDVKYKKWN 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKR--FLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP++PE+ +L KQ N +K + +EI+ A D REG+L+ ++D ++ Sbjct: 63 LEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVR 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + ++R I+ + +A++ L+ + L SA+AR+ ADW G+N TRA Sbjct: 123 I----NKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRAL 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T + L+ GRVQTP + ++ R++EI+NF A+ ++ ++A + W Sbjct: 179 TTR-----FNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQ----TTNQLKLTW 229 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + R ++ + +V + A V + K++ +P + L+ LQ + Sbjct: 230 QDANG-------NSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRD 282 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K+FG SA+ L+I QKLYE HK++TYPR+D RY+ + + A V L Sbjct: 283 ANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLA 342 Query: 361 QPVVDPDIR--NRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 V+ I+ DD KV HHAIIPT + T+ E K+Y+L+ +++L P Sbjct: 343 HKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPA 402 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN----DGTPLPVVAKGDEL 473 + + + + F+A+ + + AGW+ + ++ D++ LP + KGD L Sbjct: 403 FEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTL 462 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGI 531 + QT+ P F +ATLLSAM +++ +K L L++T GLGT ATRA I Sbjct: 463 TVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADI 522 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 I+ LF + K+G+ IH T G+ L +PE P +T WE L I++ + + + F Sbjct: 523 IDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVF 582 Query: 592 MQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 + + +++ + K + + ++ S K + K Sbjct: 583 ISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGK 630 >UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT Length = 737 Score = 574 bits (1481), Expect = e-162, Method: Composition-based stats. Identities = 252/652 (38%), Positives = 355/652 (54%), Gaps = 28/652 (4%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RL IAEKP LA+AI + L RK DG+ ECG+ + VTWC GH+L P+ YD RYA W Sbjct: 5 RLVIAEKPELAKAIVEGLGGGSRK-DGYYECGSDR-VTWCYGHMLALLDPEDYDERYANW 62 Query: 62 NLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 N+ADLPIV W+ +P Q I L +A +VHAGDPD EGQLLVDE+L+Y Sbjct: 63 NMADLPIVHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPDDEGQLLVDEILEY- 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR LIND N + V R + +R N EF L +A AR+ D LYG N+TR Sbjct: 122 ---ANCRLPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVGDQLYGFNITRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 YT+ R GYQG+LSVGRVQTP+LGLVVRR E ++ V + F A Sbjct: 179 YTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQFEVEGIQ-FPAR 237 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 +Q ++ DE+GRL ++ AE + +SGQPA + S K + +APLP++L LQ+ Sbjct: 238 YQVADG--DPVDEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLPYNLLKLQM 295 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL- 358 +A+++FG V DI Q L E HKLITY RSDC YL EE V+ AI+ AP L Sbjct: 296 DASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAIAQTAPMLA 355 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCPD 417 +P I++R ++ KV AHHAIIPT ++ LT+ E K+Y LIAR Y+ QF P Sbjct: 356 AAAQRANPTIKSRAFNSSKVSAHHAIIPTESTADLSKLTDAEQKIYLLIARAYVAQFWPK 415 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT------PLPVVAKGD 471 ++ + + + +F ++ GW+ L + +E+ +G L + G Sbjct: 416 HLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDIEQDLRKLRDGQ 475 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLG 523 C + +++T+P +T +LLS +T +A++++D L+KIL D G+G Sbjct: 476 AGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKDKGKQGEHGGIG 535 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISE 583 T ATR II LF+RG+L +KG++I ST G+ L+ +LP+ A PDMTA W I Sbjct: 536 TPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARFPDMTALWHEQQKAIQA 595 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVR-QFRGIVAPGSGGSADKKKAAPR 634 + F+ L+ + + K + + P G + K + Sbjct: 596 GERDTLSFVNELMEYIGAEVANIKDNGLNMKIDTHPCPSCGKPLRRLKKKDK 647 >UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family n=6 Tax=Bacteria RepID=Q1DEW9_MYXXD Length = 1560 Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats. Identities = 211/657 (32%), Positives = 331/657 (50%), Gaps = 51/657 (7%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKPS+AR IA VL R G+G++ GNG VVTW IGHL+ AQP + + +W+ Sbjct: 1 MLAEKPSVARDIARVLGANER-GEGWLR-GNGYVVTWAIGHLVGLAQPHEIRADWKKWSR 58 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQL 121 A LP++P W L Q V+K+ L+ E S +V A D REG+L+ + D + Sbjct: 59 ALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKC 118 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 R+ VQR ++ L +A++ RL E+ L +A+ R+RADWL G+N++R YT Sbjct: 119 ----RKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYT 174 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-----PADERF 236 + + G+ +LSVGRVQTP L +VV R+ I +FV +D+ E+ A P D + Sbjct: 175 LA--HGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALY 232 Query: 237 TAIWQPS---------EACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 W S E ++ + A+ +++R+ AI+ S + + + Sbjct: 233 KGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMA 292 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL + L+ LQ A + G SAQ L++ Q LYE HKL++YPR+ R+L V Sbjct: 293 PPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEV 352 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLI 406 +NAI + L + R DD KV HHAIIPT + + L+ +E +VY+L+ Sbjct: 353 VNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLV 412 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAK-------GKFVAKARFLAEAGWRTLL--------- 450 R+ L + D V+R + + +F + + + GW+ L Sbjct: 413 CRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPR 472 Query: 451 --------GSKERDEENDGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMT 501 ER+ E++ LP +A+ E E V+++T+PP FTDATLL+AM Sbjct: 473 LKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAME 532 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 R + +K+L +R T GLGT ATRA IIE+L R +L ++G+ + +T+ G L + Sbjct: 533 SAGRALDEKELADAMRET-GLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVV 591 Query: 562 PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 P MT WE+ L +I + + +F++ + + +++ P R R V Sbjct: 592 HPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEV 648 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 574 bits (1479), Expect = e-162, Method: Composition-based stats. Identities = 224/710 (31%), Positives = 352/710 (49%), Gaps = 85/710 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-ARW 61 L IAEKPS+AR +A ++ R+ GF+E G +V+W +GHL+ A+P+ D + RW Sbjct: 5 LIIAEKPSVARELAPLVGATQRRA-GFLE-GPDHLVSWAVGHLVGIAEPEEQDPAWAGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDYL 119 L LP++P +++L+ P Q V++R L + + +++A D REG+L+ + Sbjct: 63 TLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTGVINATDAGREGELIFRRIY--- 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L E + V+R +D+ + + +++ RL ++E L +++ ARA ADWL G+N +R Sbjct: 120 -LMAECAKPVRRLWASDMTEEGLRKSLARLLPDAEKRNLGLASFARAEADWLVGMNYSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER---- 235 +T+ G++SVGRVQTPVL L+ R EIE FV +DF+ V+ R Sbjct: 179 FTVR-----TGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTVEGVFTPGGKGRAAQG 233 Query: 236 ---------------------------------FTAIWQPSEACEPYQDEEGRLLHRPLA 262 F A+W E R+ A Sbjct: 234 GVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWHRPPELR-----ETRVDSEDEA 288 Query: 263 EHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET 322 + N +G+ +V S K S+ PLPF L+ LQ EA RFGLSA++ L Q LYET Sbjct: 289 SAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKDTLAHAQALYET 348 Query: 323 HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD---LLPQPVVDPDIRNRCWDDKKVD 379 HKLITYPR+D R+L +E FA AI PD L + ++ C DD+KV Sbjct: 349 HKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKVKFPCVDDRKVT 408 Query: 380 AHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKA 438 HHAIIPTAR L++ E ++Y +I R+++ FC +A F + + + + F+A+ Sbjct: 409 DHHAIIPTARKGDPARLSQPERQIYEMICRRFIAAFCAEARFATSTVTVKVGEHAFIARG 468 Query: 439 RFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLS 498 + E GW + + ++ TPLP + KG L + V RQT+ P H+TDA+LL+ Sbjct: 469 KVFKEKGWLAVEPWRAAED----TPLPPLRKGARLHTDDIRRVTRQTKAPAHYTDASLLA 524 Query: 499 AMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA-- 556 AM + V+D++L++ ++ GLGT ATRA +IE L +RG++ + G+ + ++D G Sbjct: 525 AMETAGKLVEDEELRQAMKE-RGLGTPATRAQVIETLLQRGYVGRHGKRLIASDRGMQVA 583 Query: 557 -LFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR 615 + +L P++T WE L + Y FM + +++ + + KR R Sbjct: 584 EVIEALLPDVASPELTGTWEKALKDMEAGTATYPQFMHGIRESVWNGVHRIKRVGGRNLD 643 Query: 616 --------------GIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + P GG + PR + PPA + G A Sbjct: 644 RLLDTASERYARTPDGLCPLCGGEV---RETPRGWACTGQPPAKKRGKAA 690 >UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6I107_9BACT Length = 739 Score = 572 bits (1474), Expect = e-161, Method: Composition-based stats. Identities = 256/660 (38%), Positives = 364/660 (55%), Gaps = 52/660 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L IAEKPS+ARAI DV G VT GH+LE A+PDAY Sbjct: 1 MKLVIAEKPSMARAIKDV-------------VGREYEVTNAFGHILELAEPDAYLPADVP 47 Query: 59 -------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 W DLPI+P +W+ P S QL I L +A +V+AGDPDREGQLL Sbjct: 48 VSIKTGRKIWRACDLPILPAEWRQIPIRSSKDQLIKIGELLKKADLVVNAGDPDREGQLL 107 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 +DE+LD+ + R +V+R ++ L+ ++++A LR N + PL +A+ R+RADWL Sbjct: 108 IDEILDHFR----YRGRVERVWLSALDKTSIDKAFRDLRDNRSYKPLSDAAMGRSRADWL 163 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N+TRA T+ S+GRVQTP L LVV RD IE F A+D+FEV+A I Sbjct: 164 VGMNLTRAATL-----SSGSFYSIGRVQTPTLALVVHRDLAIERFAARDYFEVRARIRHE 218 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESAPL 290 F+A+W+PS+ P DEEGRL R AE + + G+ A ++ Y K ES+SAPL Sbjct: 219 -RGTFSALWKPSDPSGPGFDEEGRLTDRRQAEAL--SLKGKGAGKISRYEKKEESKSAPL 275 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 P+SLSALQ A+ RFGLSA VL CQ LYE K+ +YPR+DCR+LP E F+ ++ A Sbjct: 276 PYSLSALQKAASGRFGLSADEVLKTCQSLYE-KKVTSYPRTDCRFLPVEQFSEAGRILQA 334 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 + V +P++ ++ W+ KV AH AI+PT A +L+E E K+Y++I Y Sbjct: 335 LPVSPDI---RPLISASRKHPAWNTAKVTAHPAIVPTGE-RAGDLSEKERKIYDMIVSSY 390 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE--ENDGTPLPVVA 468 L F PD + + +++ + + A R + GW L G +R+E E D LP Sbjct: 391 LALFLPDHRYFSAALSVEMNREIWTATGRQEIDPGWTRLFGRGDREEGGEEDLPSLPECR 450 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 G+ +L E GEV E++T+PP FTD TL+ AM+ I +FV+D + K+ L+ T G+GTEATR Sbjct: 451 PGEAVLGEGGEVREKKTRPPGRFTDGTLIEAMSNIHKFVEDPEAKQTLKETSGIGTEATR 510 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQ 585 AGI+E L R ++ +KG+ I ST+ G++L L P TA WE L+++S + Sbjct: 511 AGILETLVGREYIVRKGKQILSTEKGRSLVGFLEATLPDLVDPVTTARWEDDLSEVSAGK 570 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG-------IVAPGSGGSADKKKAAPRKRSA 638 R + F+ + + + G I P GG A + R + Sbjct: 571 KRVEAFVGGIADLVREQTRTLLTKGQGGLAGDPSSPAKIACPVCGGQALVTRRESRNKKG 630 >UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62_9FIRM Length = 709 Score = 568 bits (1463), Expect = e-160, Method: Composition-based stats. Identities = 204/646 (31%), Positives = 312/646 (48%), Gaps = 56/646 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L +AEKPS+A +++ V+ R GDG++E GNG +V+WC+GHL+E +QP+AYD +YA+ Sbjct: 18 MKLVLAEKPSVAMSLSKVIGADQR-GDGYME-GNGYLVSWCVGHLVELSQPEAYDEKYAK 75 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W DLPI+PE WQ Q S KQ ++K+ + ++ A D REG+L+ V Sbjct: 76 WKYDDLPILPEHWQYQVSASTKKQFGILKKLMQRKDVESLICATDAGREGELIFRLVYHQ 135 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ + A+ +LR +E+ L +AL R RADW+ GIN TR Sbjct: 136 CGC----KKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATR 191 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++ L Y L+VGRV TP L +VV RD I F + F+ + Sbjct: 192 LFSCL-----YGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKF---------- 236 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNR-ISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +Q R+ + AE +V AI+T K +SE P F L++L Sbjct: 237 --------RDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSL 288 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA ++ G +AQ LD Q LYE KL+TYPR+D RYL ++ +++ I Sbjct: 289 QREANRQLGFTAQQTLDYTQALYE-KKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQI 347 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQF 414 P P + + KKV HHAIIPT ++ + L E + ++ + + Sbjct: 348 QPDAPA--PVNTAQVINTKKVTDHHAIIPTKTAAGYDISSLPSGEQAILTMLTVRLICAV 405 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT--PLPVVAKGDE 472 + + ++E + A KF K + + + GWR G D E + LP++++G Sbjct: 406 GTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGKAVEDAEKNAEAGELPILSEGMT 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L ++ E +T PP+ FT+ LLSAM + D+ + G+GT ATRA II Sbjct: 466 LELAGVDLKEGKTSPPKRFTEDLLLSAMESAS---SDEFPAGV--ERKGIGTPATRAAII 520 Query: 533 ELLFKRGFLTKKG----RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 E L ++GF+ ++G +Y+ STD G AL +PE P MTA WE L +I + Sbjct: 521 EKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDS 580 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIV-------APGSGGSAD 627 FM + + L+ + P G Sbjct: 581 DAFMGEISSMVSGLVKTYEAVKGADVLMQPECKVIGSCPACGSDVC 626 >UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q099E1_STIAU Length = 1504 Score = 566 bits (1460), Expect = e-160, Method: Composition-based stats. Identities = 199/652 (30%), Positives = 316/652 (48%), Gaps = 56/652 (8%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKP++AR IA L R G+G+ GNG VVTW IGHL+ AQP + RW+ Sbjct: 33 VVAEKPAVARDIARALGATQR-GEGWFR-GNGYVVTWAIGHLVGLAQPHEMHPAWKRWHR 90 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQL 121 LP++P W L + Q V++ ++ E S +V A D REG+L+ + + Sbjct: 91 EQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGC 150 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 R+ V+R ++ L A+ L+ + L +A R+RADWL G+N++R YT Sbjct: 151 ----RKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYT 206 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-----PADERF 236 + LSVGRVQTP L ++V R+ I +FV +D+ EV A PA ++ Sbjct: 207 LAC-----GETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQY 261 Query: 237 TAIWQPSEACE--PYQDEEGRLLHRPLAE-----HVVNRISGQPAIVTSYNDKRESESAP 289 W + P E R R A+ V+ R+ A++ S + + + P Sbjct: 262 RGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPP 321 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ A + +G SAQ L++ Q LYE HKL++YPR+ R+L V+ Sbjct: 322 LLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVR 381 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIAR 408 AI LL + + R DD KV HHAIIPTA S L +E ++Y L+ R Sbjct: 382 AIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCR 441 Query: 409 QYLMQFCPDAVFRKCVIELDIAK----------GKFVAKARFLAEAGWRTLL-------- 450 + L + + V+ + ++ +F + + GW+ L Sbjct: 442 RLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPP 501 Query: 451 ----------GSKERDEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSA 499 + ++ E++ LP V+A+G + E E V+++T+PP TDA+LL+A Sbjct: 502 KGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTA 561 Query: 500 MTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFH 559 M R + +K+L ++ T GLGT ATRA IIE+L +R +L ++G+ + T+ G L Sbjct: 562 METAGRTLDEKELADAMKET-GLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQ 620 Query: 560 SLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 + P MT WE+ L +I Q Q F++ + + +++ + P+ Sbjct: 621 VVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPM 672 >UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychrophila RepID=Q6AJY0_DESPS Length = 820 Score = 566 bits (1460), Expect = e-160, Method: Composition-based stats. Identities = 192/618 (31%), Positives = 312/618 (50%), Gaps = 18/618 (2%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L IAEKPS+A +A VLP K E + +V++ +GHL+ P+ D Y +W Sbjct: 5 ILIIAEKPSVAGDLAKVLPGKFTKQKTHYES-DSHIVSYAVGHLVSLCYPEEIDPIYQKW 63 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 LA+LPI+PE + L+ + QLN +K+ + EI++A D REG+L+ +L Y+ Sbjct: 64 GLANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYV 123 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 ++ ++R + + +++++ + LR N L +AL R+ +DWL G+N TRA Sbjct: 124 WNTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRA 183 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T G + GRVQTP L L+V+R+ F D+ ++A+ ++ Sbjct: 184 LTGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFE-TGSYSGK 242 Query: 240 WQPSEACEPYQDE---EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 W + ++ + R+ + A ++ + +PA T N K +SAP F L+A Sbjct: 243 WIDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATE-NSKESRQSAPQLFDLTA 301 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA RFG SA+N L I Q LYE HK +TYPR+D R+LPE++ + + Sbjct: 302 LQREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEF 361 Query: 357 DLLPQPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 + + + + R +++KK+ HHAIIPT NL+E E K+Y ++ +++L Sbjct: 362 AAIAKTALKEGYIKAQTRIFNNKKISDHHAIIPTNTLPQ-NLSEPELKIYTMVVQRFLAI 420 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F P AVF + F+ + + L EAGW+ + + D P + G + Sbjct: 421 FFPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYAGADGSTGKDKILAP-IPTGSPV 479 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 C K E T PP + +ATLLSAM +F+++++L ++ GLGT ATRA IIE Sbjct: 480 TCNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKE-RGLGTPATRATIIE 538 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQ 589 L K ++ ++ + + T LF + + P+MT WE L QI + + Sbjct: 539 KLIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRD 598 Query: 590 DFMQPLVGTLYQLIDQAK 607 DFMQ + Q++D+ + Sbjct: 599 DFMQEIRQLTQQIVDRVR 616 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 566 bits (1458), Expect = e-159, Method: Composition-based stats. Identities = 221/667 (33%), Positives = 322/667 (48%), Gaps = 43/667 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS A AIA L R+ DG++E +++W IGHL+E P+AYD R+ RW Sbjct: 6 LIIAEKPSAAMAIAQALGGFQRR-DGYLESAE-YLLSWAIGHLVELLPPEAYDPRWKRWT 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + LPI+PE + L P Q + R +A +V+A D REG+L+ + L Sbjct: 64 METLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNACDAGREGELIFRYICAAAGL- 122 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V R ++ L P A+ A ++ + L SA RA DWL GIN TRA+T+ Sbjct: 123 ---EKPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCRAEGDWLVGINATRAFTV 179 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + +LS GRVQTP L +VVRR+ EIE+F + ++EV A TP +T W Sbjct: 180 -----KFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRTPDGREYTGKWFG 234 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + RL AE VV R+ Q V + +++ +E P F L++LQ EA Sbjct: 235 PDG--------DRLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTSLQREAN 286 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQP 362 +R+GL+A L Q LYE ITYPR+D RYL A++ A+S + Sbjct: 287 RRYGLTAAATLKAAQALYEAKH-ITYPRTDSRYLSRALVPQLPALVRALSARSDLAALAA 345 Query: 363 VVDPDI----RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 D R DD KV HHAI+PT+ +LT EAK+Y+LI R++L QF PDA Sbjct: 346 GADLSRVGFGNRRVVDDAKVTDHHAILPTSEVPR-SLTGAEAKIYDLIVRRFLAQFYPDA 404 Query: 419 VFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERDEENDG-------TPLPVVAK 469 F + + + + +F ++ R L + GWR + R LP + Sbjct: 405 RFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEGLQLLPPLRM 464 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + E E+ T+PPR +T+ATLLSAM R + D+ L++ ++ GLGT ATRA Sbjct: 465 GEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKG-HGLGTPATRA 523 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQ 585 IIE L + G++ + R + T G+ L E+ P++T WE + I + Sbjct: 524 AIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHRIAGIQSGE 583 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSA---KKSP 642 FMQ + +L+++ + T RG S K P + P Sbjct: 584 YDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEPAAGGPPLQDRLP 643 Query: 643 -PADEVG 648 P G Sbjct: 644 TPCPRCG 650 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 565 bits (1457), Expect = e-159, Method: Composition-based stats. Identities = 250/658 (37%), Positives = 359/658 (54%), Gaps = 51/658 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY---- 58 + IAEKPS+ARAI + L N +T GH+LEQA+PDAY Sbjct: 4 VVIAEKPSMARAIREGLGP----------QANRYEITNAFGHILEQAEPDAYLPGDVPKT 53 Query: 59 ----ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 W + DLPI+P +W+ P+ QL I L A +++AGDPDREGQLL+DE Sbjct: 54 AKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDE 113 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L++ R +V R + L+ + V +A L SN ++ PL +A AR+++DW+ G+ Sbjct: 114 ILEHFH----YRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGM 169 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N+TRA T+ + S+GRVQTP L +VVRRD EIENFV +D+FEV A Sbjct: 170 NLTRAVTV-----KSGDLFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRH-TQG 223 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A W+PS P DEEGRL+ + LAE V + G V + K + +SAPLP+SL Sbjct: 224 AFLAKWEPSSTDGPGFDEEGRLIDKRLAEAVAQKAKGA-GKVARFEAKEQKQSAPLPYSL 282 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 SALQ A+ RFG+SAQ VLD CQ LYE K+ +YPR+DCRYLPEE ++ + + Sbjct: 283 SALQKVASSRFGMSAQQVLDTCQSLYE-KKITSYPRTDCRYLPEEQLVDAPRILGKLPIP 341 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 +P+++P ++ W++ K+ AH+AI+PT A L++ EAK+Y+LI R Y+ F Sbjct: 342 DGI---RPLLNPRQKHVAWNNAKITAHNAIVPTGE-PARGLSDAEAKLYDLIWRSYVALF 397 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----SKERDEENDGTPLPVVAKG 470 PD +R + + + A R + GW+ L G + D + PLPV+ G Sbjct: 398 LPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTG 457 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + + G+V RQT+PP FTD +L+ AM+ I +FV D K L+ T GLGTEATRA Sbjct: 458 DPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRAS 517 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM----ATRPDMTAHWESVLTQISEKQC 586 ++E L +R +L KKG+ + ST G+AL L + P TA WE VL ++E + Sbjct: 518 VLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKV 577 Query: 587 RYQDFMQPLVGTLYQLIDQAK---------RTPVRQFRGIVAPGSGGSADKKKAAPRK 635 Q F + + + I+ K + + R P GG A ++ +K Sbjct: 578 PMQKFTAAVTQEVAKAIEVLKSGSAMAGGGSSSQQPLRAQPCPICGGDAVVRRLQSKK 635 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 563 bits (1451), Expect = e-159, Method: Composition-based stats. Identities = 219/662 (33%), Positives = 330/662 (49%), Gaps = 34/662 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFI----ECGNGQVVTWCIGHLLEQAQPDAYDS 56 MRL IAEKPS A+ +A P RK + I G +V W +GHL E +P Y Sbjct: 1 MRLIIAEKPSQAQKLAAPYPSKKRKEEIEISPCPRFPEGAIVVWAVGHLCELQEPSHYRP 60 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDE 114 + W LPIVPE++ + +K IK++LH+ S +++ A D +REG+ +V Sbjct: 61 EWKSWKYEALPIVPERFDYRISKGKSKPFYAIKKWLHDRSITDVIIASDAEREGEAIVRL 120 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L ++ + R I+ L QAV+R +L + +P A++RA ADWL G+ Sbjct: 121 ILRLAG----NKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYHEAMSRACADWLVGM 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RAYT L + G + V S+GRVQTP L L+V R+ EI+ FV + +FEV+A + Sbjct: 177 NASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEPYFEVEATLA-KGRG 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A + + +L R A+ VV R SG AIV + + + + E P FSL Sbjct: 236 TFKAKYT--------FGKTTKLKTREEADAVVKRASG-TAIVKTIDKEEKIEQPPFWFSL 286 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI--S 352 S LQ EA KRFG A+ LDI QKLY T I+YPR+D ++ + + S Sbjct: 287 SGLQAEAGKRFGFGAKKTLDIAQKLY-TKGWISYPRTDSGFVTPDEATLFPQTKARLLKS 345 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYL 411 L DP R + KKV H+AIIPT + L +EAK+Y+LI R++L Sbjct: 346 DAYAGLRDLLTEDPSKNRRYVNAKKVSDHYAIIPTEACGDVTRLGGDEAKLYDLINRRFL 405 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A+ K ++L + AK + G+R ++ K +D E LP + G+ Sbjct: 406 AAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVE-----LPALTVGE 460 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 E +K EV+ +QT+PP+ +T+ L+ AM + + D++L I++ +GLGTEATRA I Sbjct: 461 EFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLGTEATRANI 520 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQD 590 I+ L KRG++ + + + TD G+ L L + P MTA WE L +I + + Sbjct: 521 IDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSILASPVMTAKWEKRLHEIGQASASAAE 580 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 F++ L+++AK + G A + R G G Sbjct: 581 FIEQAKKMSVHLVEEAK----SRVEAANPEGYTIEAKRYGKKGTTRPKASFGICPNCGKG 636 Query: 651 AI 652 + Sbjct: 637 LV 638 >UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B550_METEA Length = 888 Score = 562 bits (1449), Expect = e-158, Method: Composition-based stats. Identities = 245/648 (37%), Positives = 354/648 (54%), Gaps = 21/648 (3%) Query: 2 RLFIAEKPSLARAIADVL----PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 RLFIAEKP+L RAIA L G GFIE G G VTW IGH + A+P Y S Sbjct: 4 RLFIAEKPALGRAIATALATLSGARPSAGRGFIEVG-GDCVTWTIGHAYDTAEPGDYSST 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W+L LP++PE+W+L P + Q+ V+K + V+ GD +REGQL+VDE+L Sbjct: 63 WDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYDHFVNVGDAEREGQLIVDEILI 122 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + P + V R ++ + V A+ NS+ L +A+AR RADWL G+NM+ Sbjct: 123 ENGVDPFSPK-VSRVWVSSFVEKDVAAAVAGAFPNSQKKSLYEAAVARQRADWLLGMNMS 181 Query: 178 RAYTILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 R + ++ + +G +G +SVGRVQTP L LVV RD +IENF A D F V F Sbjct: 182 RVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENFKAVDHFAPSITFVHEN-GTF 240 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A WQ A D EGRLL + +A+ +V +I+G+ V SY++ +S S PLPF+LS Sbjct: 241 KAAWQ-FPADTKGLDPEGRLLDKAVAQALVQKIAGKTGTVESYSETPKSTSPPLPFALST 299 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF-AGRHAVMNAISVHA 355 LQ +++FGL+AQ LD+ Q+LYE HK ITYPRSD ++LP ++ ++ Sbjct: 300 LQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPNSVHTDEADGILRNLAGVR 359 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL---TENEAKVYNLIARQYLM 412 +P +++ +DDKKV HH IIPT+ +SA L E E KV+ LIAR ++ Sbjct: 360 ELADAAGRANPKLKSPAFDDKKVTDHHGIIPTSEASASKLAAMGEIERKVFLLIARTFVA 419 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT-PLPVVAKGD 471 QF PD + + +F A + + GW+T+ G++E DEE + LP + D Sbjct: 420 QFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAEEADEEEEAEGTLPSMKMKD 479 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + G + ++T+PP HF D TL+ AM I +VQD++++K LR DG+GTEATRA + Sbjct: 480 PVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEVRKRLRENDGIGTEATRASM 539 Query: 532 IELLFKRGFLTK----KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 IE L + +L + K + + STDAG+ L LP PD TA WES L ++ + Sbjct: 540 IEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLPSDLVAPDTTAMWESFLERVKGGEFT 599 Query: 588 YQDFMQPLVGTLYQLIDQAK---RTPVRQFRGIVAPGSGGSADKKKAA 632 FM + + + A V+ F G G +A Sbjct: 600 LAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGHGTECPHCRAG 647 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 562 bits (1448), Expect = e-158, Method: Composition-based stats. Identities = 206/618 (33%), Positives = 330/618 (53%), Gaps = 24/618 (3%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA+ L KG I + +++ +GH++E P DSR+ +W+ Sbjct: 5 LVIAEKPSVAQDIAEALGG-FPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHRQWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L++LPI+P + L+P +LN++ LH + I++A D REG+L+ ++ + Q Sbjct: 64 LSNLPILPSSFSLKPIQKHKDRLNLLLSLLHREDVDLIINACDAGREGELVFRYLIRFAQ 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + +QR + + A+ A LR E L +A++R+ +DWL GIN TRA Sbjct: 124 V----NKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAVSRSESDWLIGINGTRAL 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L N+ + SVGRVQTP L LVV RD+EI +F K ++E+ A + E + A W Sbjct: 180 TALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWEILATFRSKQGE-YKAKW 238 Query: 241 QPSEACEPYQDEEG-RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + +D R+ + + ++ + + IVT K +S PL + L++LQ Sbjct: 239 FSRNSQHEGEDNHPERIENEDQCQSIIEKCLNKEGIVTE-EKKVSQQSPPLLYDLTSLQR 297 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS-----VH 354 EA RFG SAQ L I Q LYE HKLITYPR+D ++LPE++ V+ +S Sbjct: 298 EANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYVPRVKEVLKNLSHGPFETF 357 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 A ++L Q V P N+ ++++KV H AIIPT L NE K+Y LI R++L F Sbjct: 358 AREILSQNWVQPA--NKIFNNQKVSDHFAIIPTTHKP-TTLNANEEKIYQLIVRRFLATF 414 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P A + + + F + + L AGW + + + L + +G+++L Sbjct: 415 YPPAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSNPAQNTEEDVLCPIEQGEKVL 474 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 E + ++T+PP HFT+ATLLSAM + V+D+ L++ + A GLGT ATRAGIIE Sbjct: 475 NLAMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETLREAM-AKKGLGTPATRAGIIEG 533 Query: 535 LFKRGFLTKK-GRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQ 589 L + G++ ++ G+ + +T AL L + ++T WE L + +++ + Sbjct: 534 LIEDGYIRRQDGKALVATPKAFALIELLSAAQIQTLRSAELTGEWEFKLQMMEKEKYSQE 593 Query: 590 DFMQPLVGTLYQLIDQAK 607 FM+ + ++D+AK Sbjct: 594 KFMEEIYQLTASIVDKAK 611 >UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6_OPITP Length = 939 Score = 561 bits (1447), Expect = e-158, Method: Composition-based stats. Identities = 203/637 (31%), Positives = 320/637 (50%), Gaps = 40/637 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-Y 58 M+ L IAEKPS+A +A L K ++GD + + VV++ +GHL+E P+ D + Y Sbjct: 1 MKSLVIAEKPSVAADLARALGKIPKQGDHY--ENDQYVVSYAVGHLVELEMPEDIDKKKY 58 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVL 116 W L LPI+PEK+ L+P + N +K+ L + +++A D REG+L+ + Sbjct: 59 GFWRLETLPIIPEKFGLKPIEESKDRFNALKKLLARKDIELVINACDAGREGELIFAYLY 118 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + + V+R + + + + A LR + L +A R+ +DWL GIN Sbjct: 119 QLTKC----KLPVKRAWMQTMTAEGIREAFAHLRDGEQMAGLAAAARCRSESDWLIGING 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA T + V SVGRVQTP L +V R+ EI NF + ++++ A R+ Sbjct: 175 TRALTKRMFGSRAGNVASVGRVQTPTLAIVYSRELEIRNFKPRAYWQITATFEVTN-GRY 233 Query: 237 TAIWQPSEACEPYQDEE---GRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +Q + + DE R+ + +AE +V GQP K ++ AP + Sbjct: 234 EGTYQRPDFKKSDADEHDRVDRIWEQAVAEAIVAACQGQPPAAVREEKKASTQIAPRLYD 293 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA--- 350 L+ LQ EA RFGLSA+ L I Q LYE HK+ITYPR+D R LPE++ + Sbjct: 294 LTTLQREANNRFGLSARRTLQIAQALYERHKMITYPRTDSRALPEDYIPTVRETLKNLHG 353 Query: 351 -ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 ++ HA +L Q V P+ R +++ ++ H AIIPTA + +L E EAKV+++IAR+ Sbjct: 354 PLAPHAQQVLDQGWVRPN--RRIFNNAQISDHFAIIPTAHEAK-HLDEMEAKVFDMIARR 410 Query: 410 YLMQFCPDAVFR-KCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVV 467 ++ F P A F I + +F + + L GW + G +++ G+ LP + Sbjct: 411 FVAAFFPPAEFDITTRISTVAGRHEFKTEGKVLTVPGWLAVYGRTTVEDDAPGSKSLPAL 470 Query: 468 AKGDELLCEKGE------------VVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 + D +G+ + T+PP +T+ATLLSAM G + V D+DL + Sbjct: 471 SDADRATVARGDDAPAQAKTLDPVLHAETTKPPPRYTEATLLSAMEGAGKLVDDEDLAEA 530 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMT 571 ++ GLGT ATRA I+ L + ++ + R + T + L L + T P MT Sbjct: 531 MKE-RGLGTPATRADTIDGLINQKYMERGQRELIPTAKAEQLLQFLSAVHTDALTSPAMT 589 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 WE L QI + ++FMQ +V ++D+ K Sbjct: 590 GEWEFKLRQIEHGKFSREEFMQEVVEQTKGIVDRVKN 626 >UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q9F544_ECOLX Length = 718 Score = 559 bits (1442), Expect = e-157, Method: Composition-based stats. Identities = 231/661 (34%), Positives = 351/661 (53%), Gaps = 41/661 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP++A I L + DG+ E + +VT C GH++E P+ Y+ Y Sbjct: 1 MKLFIAEKPAVANDIVKALGGNFTRHDGWFES-DNTIVTNCFGHIIESQPPENYNPEYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W + LP+ + QP S KQ+ I + A EI+HAGDPD EGQLLVDEVL+Y Sbjct: 60 WKIETLPLRLYPVKYQPVESAEKQVKTIIELIRRADVTEIIHAGDPDDEGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R LIND AV++A+ ++N +F L + ALAR+ AD +YG++MTR Sbjct: 120 AG----NTKPVKRVLINDNTLPAVKKALANPKNNRDFRGLYLKALARSVADAIYGLSMTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI + GY+GVLSVGRVQTPVLGL+V R +N + ++ + H + A Sbjct: 176 AYTIPAKTKGYKGVLSVGRVQTPVLGLIVNRTRANKNHKSSFYYTMTGHFQR-GADVIRA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+P E + +LL + A ++G+PA V + + +APLPF+L LQ Sbjct: 235 NWKPGEFAPLT---DRKLLDKTWANGTATSLAGKPATVEAAATDDKKTAAPLPFNLVRLQ 291 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 K+F ++AQ LDI Q+L E +K ITY RSDC YL +E F+ +++A+ Sbjct: 292 QYMNKKFKMTAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQIIDALKSVFDQP 351 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 + +D +++ ++ KV AH AIIPT +N L+ +E VY IA+ YL+QF P+ Sbjct: 352 MD---IDTTRKSKAFNSAKVTAHTAIIPTVSVPDVNALSTDERNVYLAIAQHYLVQFMPE 408 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE--------RDEENDGTPLPVVAK 469 +++ + + F A+AR ++G+ LG + ++++D L + Sbjct: 409 KAYQEVSVAIQCGDESFYARARKTTDSGFEAFLGVENAGDDEAEVENDDSDFDLLCKIRT 468 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 G+ + ++ V E++T PP FT+ATLL+A+ +A FV D +KK+L+ D G Sbjct: 469 GETVTTKEVVVNEKKTTPPPLFTEATLLAALVRVADFVTDPVIKKLLKEKDRDKKDEHGG 528 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 +GT ATRA I+E L KR ++T + + TD G AL +LP++A PDMTA W T I Sbjct: 529 IGTPATRASILETLKKRNYITLEKGKLIPTDTGYALIDALPDIAVNPDMTALWAEKQTLI 588 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR----------QFRGIVAPGSGGSADKKKA 631 + + F+ L L +I A ++ Q P G + Sbjct: 589 ENGEMTIEQFVDELYNDLIPMISNANSAEIKVSPSAPSGQSQRLSSPCPSCGKQIVIRPK 648 Query: 632 A 632 + Sbjct: 649 S 649 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats. Identities = 177/634 (27%), Positives = 303/634 (47%), Gaps = 20/634 (3%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A + VL K + + +V+ IGHL+ A P D RY W+ Sbjct: 35 LIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDIDERYKAWD 94 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 + LP++PEK+ L P+ L+ + + + I++A D REG+L+ ++DY+ Sbjct: 95 MKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELIFYYIVDYIL 154 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 K + +R + + P A++ A + LR+ + V L +AL R+ ADWL G+N +R Sbjct: 155 KGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWLVGMNGSRGL 214 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T + G + GRVQTP L ++V+R+EE F+ + F+ ++A + W Sbjct: 215 TAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWTIEASFDNAGAG-YQGKW 273 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E +D ++ A+ ++ + G+ + + + + L+ LQ E Sbjct: 274 FTVDK-ENGKDRVKQIFDEARAQEILAKCKGKTGSIEETTAPSQQKCG-QLYDLTTLQRE 331 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A RFG SA+ L I Q LYE +K TYPR+D R LPE++ A A + I Sbjct: 332 ANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVKATLGKIEGPLAKFAQ 391 Query: 361 QPVVDPDIRN--RCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 + + ++ + +D+ K+ H AIIPT L+E E K+Y +I ++++ F P A Sbjct: 392 EALDKNYVKRTPKVFDNSKISDHFAIIPTGVVPK-GLSEAEEKIYTMICQRFIAVFFPPA 450 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + + F+ + + L + G++ + G + +E N +P + G+ Sbjct: 451 QYLNTTRITTVENETFITEGKILVDPGFKAIYGKESDEESN----IPKLN-GNTAKTLAI 505 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 E E T+PP H+T++TLLS M + V+D +L+ ++ GLGT ATRA IIE L Sbjct: 506 ESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKE-RGLGTPATRAAIIEKLVSD 564 Query: 539 GFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 ++ + G+ + T L L E T P++T WE + IS+ + + FM Sbjct: 565 KYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEYKMDLISKGKESREAFMNG 624 Query: 595 LVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSA 626 ++ ++ K + +P +G Sbjct: 625 IIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKV 658 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 557 bits (1435), Expect = e-157, Method: Composition-based stats. Identities = 199/679 (29%), Positives = 328/679 (48%), Gaps = 65/679 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+AR I L + + F G VVT +GH+LE PD + + +W Sbjct: 5 LVITEKPSVARDITRALGGFQNEKNFF--EGPEHVVTSAVGHMLELVAPDGVEVQRGKWA 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +LP++P+ + L+P QL +IK+ + +++A D REG+L+ ++ + + Sbjct: 63 LVNLPVIPDHFDLKPIQQNESQLKLIKKLYARKDIDSVINACDAGREGELIFHYLIRHFK 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + V+R + + PQA+ +RLR +PL +A+ R+ +DWL GIN TRA Sbjct: 123 GS----KPVRRLWLQSMTPQAIRDGFERLRDGETLLPLQRAAVCRSESDWLIGINATRAM 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L + G + +VGRVQTP L L+V R++EI++F ++++EVKA A R+ W Sbjct: 179 TALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPREYWEVKAIFAI-ASGRYEGYW 237 Query: 241 QPSE--------------ACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 + + + R+ + AE +V + + + V+ K S+ Sbjct: 238 VDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIVAQCANREGRVSE-TTKPSSQ 296 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P+ F L++LQ EA +RFG SA+ L I Q LYE HK++TYPR+D R LPE++ Sbjct: 297 QPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVLTYPRTDSRTLPEDYPKTVGT 356 Query: 347 VMNAIS-------------------VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 +M ++ H + + Q R +++ +V H AIIPT Sbjct: 357 IMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYINGKNRRIFNNAQVSDHFAIIPT 416 Query: 388 ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWR 447 + L E E ++Y L+ R ++ F P A F V + F + R L E+GW Sbjct: 417 GEAP-GKLKEQERRIYELVTRCFIAAFYPPARFENTVRRTVVEHQTFETRGRVLIESGWL 475 Query: 448 TLLGSKERDEENDGTPLPVVA-----KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 ++G KE +E LP +A + + ++ +QT+ P + +ATLLSAM G Sbjct: 476 QVMGRKESNE-----TLPPLASTAQDDSERAETVEIDLEGKQTKAPPRYNEATLLSAMEG 530 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 + ++D +L++ L+ GLGT ATRA IIE L + ++ + R + T L L Sbjct: 531 AGKLMEDDELREALQG-RGLGTPATRAAIIEELIRNRYILRDARELIPTAKATTLLRLLR 589 Query: 563 ----EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR--- 615 + T ++T WE L QI Q ++FM+ + +++ A++ V Q Sbjct: 590 ALKIDELTTAELTGEWEKKLKQIESDQFSSEEFMRHIRRMTADIVEAARQCDVDQIDDEY 649 Query: 616 ---GIVAPGSGGSADKKKA 631 + P G ++ Sbjct: 650 AVLAVPCPKCGQGRVRENY 668 >UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermedia K12 RepID=C7HY28_THIIN Length = 723 Score = 555 bits (1431), Expect = e-156, Method: Composition-based stats. Identities = 247/660 (37%), Positives = 358/660 (54%), Gaps = 32/660 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-VTWCIGHLLEQAQPDAYDSRYA 59 MRL IAEKPS+A+AIADV+ R+GDG+I+C + VTWC GHLLEQA+P+ Y + Sbjct: 1 MRLIIAEKPSVAQAIADVIGG-VRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDYVNG-G 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVT-KQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + + LP++P W+L PR KQ+ I+ L +A+E+V+AGD DREGQLLVDEVL + Sbjct: 59 KVLASHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAGDADREGQLLVDEVLLF 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + + R ++ L+ ++V RA+ ++SN PL SALAR RADWL G+N + Sbjct: 119 LNW----KGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQRADWLMGMNASI 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A + + G QG SVGRVQTP L L+V R +I+NF +D ++V+A + A Sbjct: 175 ALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQATLDGD----IRA 230 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +WQ E Q ++G LL + AE + GQ A V ++ K AP+P++LS LQ Sbjct: 231 LWQ---IPEDLQTDDGLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPYALSTLQ 287 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A+ R GLSA++ L Q+LYE KL TYPRSDC +LP E A ++ A+ Sbjct: 288 KTASSRLGLSAKDTLAAAQELYEA-KLATYPRSDCPWLPVEMHAAAAQIIRALGA----- 341 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR--SSAINLTENEAKVYNLIARQYLMQFCP 416 +DP+ R+ W+ KV+AHH IIPT R + L+EN K+Y L+ YL F P Sbjct: 342 AEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGLAEVSGLSENAKKIYGLLRESYLRLFMP 401 Query: 417 DAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTL---LGSKERDEENDGTPLPVVAKGDE 472 F +F A AR + E+GW L S E DE LP++ +G + Sbjct: 402 PETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTEGQQ 461 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L CE +V+ ++T PP+ +TD TL++AMTG+ + V D LK L+ T GLGTEATRA +I Sbjct: 462 LACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMI 521 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQ 589 E+L R + +K + IH T+ G L L ++ P TA E L I+ + + Sbjct: 522 EVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARSTFD 581 Query: 590 DFMQPLVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 +FM + + + + + P GG ++ + + + D Sbjct: 582 EFMTAQIDAVRESTQKLLGGQLGATPAILHACPACGGGRCAQRTSKAGATYHRCLDCDAA 641 >UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria RepID=Q4L0S6_HAEIN Length = 750 Score = 554 bits (1429), Expect = e-156, Method: Composition-based stats. Identities = 217/668 (32%), Positives = 343/668 (51%), Gaps = 23/668 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKP L IA+ + RK DG+IEC G VTW IGH+LE +P+ + Y Sbjct: 1 MRLVIAEKPQLGAVIAEAIGIVGRK-DGYIECKGGYNVTWAIGHVLELKEPNEINPAYKN 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN DLP+ +L+P+ + KQ +I+ L +A +V+AGDPD EGQLL+ E+L+Y Sbjct: 60 WNAKDLPLKLRPMELKPKANTEKQFRIIESLLKKADTVVNAGDPDDEGQLLIREILEYTG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R L+NDLN +A +A+ L+ +SEF + ALAR+ AD+++G+N++RAY Sbjct: 120 F----KGTVERLLLNDLNVEAARKAMKNLKPDSEFDGMYYKALARSHADYIFGMNLSRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA---DERFT 237 T+ R G V S+GRVQTPVLGL+VRR +N ++ + + + R Sbjct: 176 TLSAREKGLDSVYSIGRVQTPVLGLIVRRYLANKNHKESFYYNLSGNFSFQDKTLNARLV 235 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 S + +E R++ +A+++ + + ++ APLPF+L L Sbjct: 236 ITDNISTDPNDEESKEKRIIDENIAKNIQKDCEKHTVNIIQCGIEAKTTPAPLPFALLDL 295 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q + ++G SA L I Q L E H+ ITY RSDCRYL E F ++ +S P+ Sbjct: 296 QAKINDKYGFSADETLAITQSLREKHQAITYNRSDCRYLSTEQFEAAPKTLDFLSGLFPE 355 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQF 414 LP D ++R ++DKKV AH IIP N L++ E KVY I QYL+QF Sbjct: 356 -LPFNSADRSRKSRAFNDKKVTAHTGIIPVVSDKFSNISALSDKEQKVYRAIVEQYLVQF 414 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT--PLPVVAKGDE 472 P+ + + + + +F A + + GW L+ DE ++ + + Sbjct: 415 LPEKQYDLASVTIQCSDYQFRTSATKITDHGWSKLVPDDAEDENDNAKFDLIASLQADAS 474 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGT 524 +CE E+ + +T+P +T+ATLL + +AR+++D +KK+L D G+GT Sbjct: 475 GMCESVEIKKEKTKPQPIYTEATLLKDLQRVARYIEDPRIKKLLIEKDKGREGENGGIGT 534 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 ATR+ +I+ L +GF +G+ + T G +LP + T PD TA W I + Sbjct: 535 PATRSAVIKNLHDKGFFEYQGKKLIPTQKGIDFIEALPRIVTVPDTTALWFEQQLAIEKG 594 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + +F+ + + + I+ AK + + +G G KK + A + P Sbjct: 595 ELSVDEFLDEIEKFVGEQIEAAKNVKL-EVKGEPCSCGQGVLVLKKFKDSEFFACTAYPT 653 Query: 645 DEVGSGAI 652 ++ A+ Sbjct: 654 CKITKPAL 661 >UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID=B1HX02_LYSSC Length = 725 Score = 553 bits (1426), Expect = e-156, Method: Composition-based stats. Identities = 207/658 (31%), Positives = 322/658 (48%), Gaps = 33/658 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECG------NGQVVTWCIGHLLEQAQPDAY 54 M++ IA KP A +A P G+ E NG ++TW GHL E P+ Y Sbjct: 1 MKIVIAAKPDQAAKLAA--PWSFTIKTGYFEVKANSYFPNGAIITWATGHLCELKTPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLV 112 DS + +W L LPI+P++++ + S KQ +IK + A EI+ GD REG+L++ Sbjct: 59 DSTWKKWKLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQEIIIGGDAGREGELII 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L + + ++R I+ L +V+ L ++ + AL+R+ ADWL Sbjct: 119 RTILRVCGV----NKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIYYEALSRSCADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 GIN +R YT+L + G + V S+GRVQTP L L+V R+ EI NF ++ F+EV+A Sbjct: 175 GINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSEPFWEVEAVFHFAG 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 A W +++ R+L A + N + +T + + + PL F Sbjct: 235 KM-LKAKW--------HKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKEYAPPLLF 285 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS LQ A K + S Q LDI QKLY L++YPRSD ++L E ++N +S Sbjct: 286 NLSGLQATANKAYKFSPQKTLDILQKLY-VKGLVSYPRSDSQFLTSEEAKTLPTILNNLS 344 Query: 353 --VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQ 409 +LLP P+ R ++KKV HHAII T + L+ E K+Y+L+ARQ Sbjct: 345 KMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTEQMPNLSKLSMEEEKIYDLVARQ 404 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVV 467 + A+F I + K +F++K + E GWR + +K+ + + LP++ Sbjct: 405 VIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQEEEEMLPLL 464 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + + + V + TQPP +++ L++ M + + D +L+K+L T+GLGTEAT Sbjct: 465 HENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSKTEGLGTEAT 524 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQ 585 RAGII L R ++ K + +T G L +L + T P MTA WE L +I E Sbjct: 525 RAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGENSLLTSPSMTAKWEQRLAEIGEGH 584 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQF--RGIVAPGSGGSADKKKAAPRKRSAKKS 641 Q FM+ + Y+LI A + V S + +KK K K Sbjct: 585 ASPQAFMEQVKKLTYKLITDAHEREKAWTFDQKEVEKISANNPYQKKYKKEKTVVGKC 642 >UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LWM4_9FIRM Length = 714 Score = 552 bits (1422), Expect = e-155, Method: Composition-based stats. Identities = 214/648 (33%), Positives = 344/648 (53%), Gaps = 30/648 (4%) Query: 3 LFIAEKPSLARAIADVL--PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 ++IAEKP + RA+A L KG G G+ VTW GH+L A P+ Y Y Sbjct: 7 VYIAEKPDIGRAVAAYLWPDGGMEKGKGCFRKGD-IAVTWAFGHILGMATPELYGEEYKV 65 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+ + PI+P W ++P P +QL++IK + +A +VHAGDPDREGQLL+DE+LD+L Sbjct: 66 WS--NYPILPSTWLMKPDPQKKEQLDIIKGLIKDADVVVHAGDPDREGQLLIDEILDFLH 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +V+R LIN + ++++RA LR N +F L + L RARADWL G+N++RAY Sbjct: 124 ----YKGEVRRILINAKDDESLKRAFASLRDNKDFYGLYEAGLGRARADWLIGMNLSRAY 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ R AG+ G +GRV+ P L LVV+R+++I +F K ++ ++ FTA Sbjct: 180 TVNARKAGHDGTYRIGRVKVPTLALVVQREKDILSFKPKKYYVLQGIFAYKG-VPFTATL 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 +PSE DEEGR+L L + + ++ ++ + PLP+SL LQIE Sbjct: 239 EPSENIPL--DEEGRVLDVNLLQAIKLKVEKAEGVIRDVATSEGKQYPPLPYSLDTLQIE 296 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K +G S Q VL+ QKLYE KL++YPRSDC Y+P ++ A+ D+ Sbjct: 297 ANKIWGYSPQEVLETVQKLYE-RKLVSYPRSDCNYIPASQREDVPRILAALKEM--DVQG 353 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 + DI ++ ++D K+ AHHAIIPT ++ E E ++Y +I+++Y++QF P F Sbjct: 354 AAGANVDIESKAFNDGKITAHHAIIPTGIRPE-DMNEQEERIYGMISKRYIIQFYPPHEF 412 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 K L + F + + + G+R +E +E+ LP A GD++ + Sbjct: 413 EKTTFSLQVGDEMFSGSGKIIRKMGFRE--VEREEEEQEGTPRLPDFAVGDKIAKGDYSI 470 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQ-DKDLKKILRATDGLGTEATRAGIIELLFKRG 539 + ++T+PP+ FT+ TL++AMT I +F++ D ++ ++ G+GT ATR II L Sbjct: 471 LNKKTKPPKRFTEGTLIAAMTNIWKFMKADNPNREKMKEVKGIGTPATRDTIIAELQATS 530 Query: 540 F--------LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 L K + + T G +L ++ PD TA E L +I+ + D+ Sbjct: 531 LKGKAVEPCLKKVKKELLPTPFGISLIENVSPSLAVPDTTAEMEYALDEIAHGKGNLSDY 590 Query: 592 MQPLVGTLYQLIDQAKRTPV---RQFRGIVAPGSGGSADKKKAAPRKR 636 M + +++ I A++ + + P +K + + + Sbjct: 591 MDDVYSMVHENIQFAEKHLFPLPKDKKRTPCPICREGILLRKYSQKSK 638 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 552 bits (1422), Expect = e-155, Method: Composition-based stats. Identities = 189/662 (28%), Positives = 299/662 (45%), Gaps = 52/662 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA L R D ++E + +++ GHL+E S + Sbjct: 5 LIIAEKPSVAKDIALALGGFGR-VDNWLESPDA-IISSAQGHLVEVFSTLMDTSGK---D 59 Query: 63 LADLPIVPEKWQLQPRPSVTK--QLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 L LP++P + L+ + +KR + + +V+A D REG+L+ + Sbjct: 60 LQSLPVIPPSFDLRVIDGANRPQLFAQLKRLMSRQDVDAVVNACDAGREGELIFRLIYKL 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++R + P+A+ + ++ ++F L +A R D+L GIN +R Sbjct: 120 AGCT----KPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSDAAFCRTEGDYLVGINGSR 175 Query: 179 AYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 T + R SVGRVQTP LV R+ I F AKD++EV H A Sbjct: 176 GVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAKDYWEVHGHFGVAAGNYVG 235 Query: 238 AIWQPSEACEPYQDEEG-------------RLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 + P+ Q E G R + A+ +V + SG K Sbjct: 236 KWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIVAKCSGTNPTDVREESKPT 295 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 ++ +P + L++LQ EA ++ GLS++ LDI Q LYE HK+ TYPR+D +LPE++ A Sbjct: 296 AKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVTTYPRTDSSFLPEDYVAKA 355 Query: 345 HAVMNAI-----SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENE 399 + + ++ HA ++ V PD + +D+ K+ H AIIPT + LT E Sbjct: 356 QSTIESLVGTTYEPHAKRVIDGGWVKPD--KKIFDNGKISDHFAIIPTGKRPE-GLTPEE 412 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 KVY++I R++L F P A ++ +A F + R L GW + G+ DE+ Sbjct: 413 GKVYDMIVRRFLAVFHPAAQYQVTTRITVVAGEHFKSSGRVLISEGWMAVYGADVDDEDK 472 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 L G+ + + E+ +T+PP +T+ TLL+AM +FV D +L ++ Sbjct: 473 KTPALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLLAAMESAGKFVDDDELADAMKE- 531 Query: 520 DGLGTEATRAGIIELLF---------KRGFLTKKGRYIHSTDAGKALFHSLP----EMAT 566 GLGT ATRA IIE L K +L + G+ + T +L L E+ Sbjct: 532 RGLGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLVPTPKLISLIEFLRNNGIELLA 591 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP---VRQFRGIVAPGSG 623 P +T WE L I + R F + Q+ID ++ V + P G Sbjct: 592 SPKLTGEWEHKLRLIERGEYRRDAFNNEIGDLTRQIIDAIRKKAAEVVVKKLDAKCPQCG 651 Query: 624 GS 625 G Sbjct: 652 GE 653 >UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamiensis G4 RepID=A4JW73_BURVG Length = 823 Score = 552 bits (1422), Expect = e-155, Method: Composition-based stats. Identities = 202/660 (30%), Positives = 308/660 (46%), Gaps = 52/660 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+A IA L K DG+ E + +V GHL+EQ P A W Sbjct: 5 LIVAEKPSVAADIAKALGG-FTKADGYFER-DDAIVAPARGHLVEQTVPAA--DAKGMWK 60 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P+ ++L+ T + + +K+ + +V+A D REG+L+ + + Sbjct: 61 IGVLPIIPDSFELEVIDGCTAEFSRLKKLMARDDVASVVNACDAGREGELIFRLIYNKAG 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ +R I + A+ +A D LR +EF L +A R+ ADW+ G+N TRA Sbjct: 121 C----RKPTKRMWIQSMVASAIRKAHDDLRPGAEFDHLSDAAFCRSEADWIVGVNGTRAT 176 Query: 181 TILG-RNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L R + V VGRVQTP L + V R+ EI FVA+D++E+ A Sbjct: 177 TALRERKTQRREVSPVGRVQTPTLAMPVIREREIAAFVARDYWEIHGTFRAEAGTYVAKW 236 Query: 240 WQPSEACEPYQDEEG-----------RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 ++ + EG R + A+ +V++ G K E A Sbjct: 237 IGDADGDTSPAETEGDAEAEAEQTGARCFDKAKAQAIVDKCKGVDPSSVVDESKPEERPA 296 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 P F L+ALQ EA KRF SA+ LDI Q LYE HK TYPR+D R LPE++ A + Sbjct: 297 PALFDLTALQREANKRFKFSAKKTLDIAQALYEKHKATTYPRTDSRALPEDYLETAAATL 356 Query: 349 NA-----ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVY 403 + HA ++ V PD R +++ + H AI+PT + L+ +E K+Y Sbjct: 357 ATFASTPLEAHAQRVIENGWVKPD--KRIFNNADISDHFAIVPTGQQPD-GLSSDEQKIY 413 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 +L++R+++ F P A + K V +A F + L E GW + G K D+ Sbjct: 414 DLVSRRFIAVFHPSAKYEKTVRTTIVAGETFRTSGKVLVEPGWLAVYGEKAHDD--TAAA 471 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 L VA G+ + + E+ QT+PP+ +T+ATLL+AM R V+DKD++ ++A +G+G Sbjct: 472 LCKVADGEAVTADAIELKALQTKPPKRYTEATLLAAMENAGRQVEDKDIRAAMKA-NGIG 530 Query: 524 TEATRAGIIELLFKRG---------FLTKKGRYIHSTDAGKALFHSLPE----MATRPDM 570 ATRA IIE L + +L + + T L L E P M Sbjct: 531 RPATRAAIIEGLLEDKDKNDNPKEPYLRRDDNELVPTPKAMELIAFLEEAGIDFLVSPQM 590 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR------TPVRQFRGIVAPGSGG 624 T WE L ++ + R FM + +++ + PV + P G Sbjct: 591 TGEWEQKLLRMEKGDYRRSTFMSEIADLSTGMVETIRAKYNELPEPVAKALDAPCPRCGA 650 >UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QH35_DESAH Length = 855 Score = 551 bits (1421), Expect = e-155, Method: Composition-based stats. Identities = 189/660 (28%), Positives = 329/660 (49%), Gaps = 35/660 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + EK S+A A L ++K DG+ E G+ V+TW +GHL+E +PD YD+ +W Sbjct: 4 LILTEKFSVASDFAKALGVKNKK-DGYFE-GDAHVITWAVGHLVELFEPDDYDAGLKKWR 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP++PE+++ +P +Q IK L + I+ A D REG+++ +L L+ Sbjct: 62 VETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTIL--LE 119 Query: 121 LAPEKRQQVQRCLIN-DLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 ++++ R + L P+ V +++L+ +++ L + R +DWL G+N+TR Sbjct: 120 SGFRDKERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRL 179 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ + SVGRVQT VL ++V R E E+F+ + ++ K R+T Sbjct: 180 MTVRL-----GDLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKVLFSGDK-GRWTGR 233 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESESAPLPFSLSAL 297 W ++++E R+ +P A+ ++ R + P +V S + + E PL FSL+ L Sbjct: 234 W--------FKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTDL 285 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA RFG A+ L I Q LY+ K ++YPR+D + L + V+ + PD Sbjct: 286 QQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACPD 345 Query: 358 LLP--QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 L P R ++D K+ HHA+IP S + +E +++L+ R++ F Sbjct: 346 LFAFVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEAA-SRDEKLLFDLVVRRFAAAFH 404 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 PD F + AK F + + + + GW+ + G+ RD+ + +P + +GDE Sbjct: 405 PDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRDK-AEAEIIPPLVEGDEGAV 463 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EK E E+QT PP ++D+ LL MT R+V ++++K++ R G+GT++TRA IIE L Sbjct: 464 EKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQIIETL 523 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPE-----MATRPDMTAHWESVLTQISEKQCRYQD 590 RG++ + G+ + +TD G L L + + T P+ TA WE L I+ + Sbjct: 524 ISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGSDIR 583 Query: 591 FMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 F+ + + + + K V+ F+ + + + K+ ++ G Sbjct: 584 FLDHIKAFVTNAVAELKSAGLNVKLFKAEQPQAAVIGICPACGKAVRENP-KAFSCEDRG 642 >UniRef50_C6BT42 DNA topoisomerase type IA central domain protein n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BT42_DESAD Length = 720 Score = 551 bits (1420), Expect = e-155, Method: Composition-based stats. Identities = 238/661 (36%), Positives = 349/661 (52%), Gaps = 23/661 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEK +A AI+ L P R + NG +TW GH+L P+ +D RY Sbjct: 1 MRLFIAEKRDVALAISQALGGPDRPTGAAFQV-NGDRITWLWGHVLRLTDPEEHDERYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LP+ P L I H+A E+V+AGDPD EGQ LVDEV+++ Sbjct: 60 WDLNTLPMKWPV-TYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 L + +R LIND N A+ +A+ + +NS++ L +SALARA D YG N+TR Y Sbjct: 119 LL---EKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L + GYQGVLSVGRVQTP+LGLVV RD E + + VKA I P+ + A + Sbjct: 176 STLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPS-QLVEAEY 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P++ + DE+GR+ + + N + GQPA V S PLP++L ALQ + Sbjct: 235 IPAD--DAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQAD 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA + + VL+I Q+L + HK ITY RSDCRYL +E A ++ A++ D+ Sbjct: 293 AAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDM-- 350 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAV 419 P+++++ ++ KKV AHHAIIPT + L E+E ++Y LI + Y+ QF A Sbjct: 351 AEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAE 410 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAKGDELLCEK 477 F +EL IA KF A+ R + GWR L +D E L + + D E Sbjct: 411 FVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVES 470 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL--------RATDGLGTEATRA 529 E V+ T+PP +T +LL +T +A++V D ++KK+ + G+GT ATR Sbjct: 471 AESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRD 530 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 IE LF+RGF+ +K + + ST+ G+ +LPE A +PDMTA W QI + Y Sbjct: 531 SHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYL 590 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR-QFRGIVAPGSGGSADKKKAAPRKRS-AKKSPPADEV 647 ++ + G++ Q I + KR + + + P K + P+ + + P Sbjct: 591 QLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNA 650 Query: 648 G 648 Sbjct: 651 T 651 >UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q48AZ8_PSE14 Length = 721 Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats. Identities = 226/651 (34%), Positives = 330/651 (50%), Gaps = 34/651 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+FIAEKP+L + IA+ L RK DG+ ECG+ +VTWC+GHLL A P+ ++ Y Sbjct: 1 MRVFIAEKPALGQVIAEALGTVIRK-DGYFECGSNNIVTWCVGHLLALAPPEVHNPAYKD 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W ADLP+ QP QL V+++ + ASEIVHAGDPD EGQLLV+EVL+Y Sbjct: 60 WVQADLPLKLRPAMYQPIARTRDQLKVVQQLIGRASEIVHAGDPDDEGQLLVEEVLEYFG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R LIND+N A +A++ LR N EF L ALAR+ D LYG NMTRA Sbjct: 120 ----NTAPVKRILINDMNANAARKALEGLRDNREFYGLYQKALARSIGDQLYGFNMTRAC 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ GR G + VLSVGRVQTP+LGL+V R ++ + ++ V A + A Sbjct: 176 TLAGRAKGVKSVLSVGRVQTPILGLIVNRYLANKSHASTFYYSVAASLAVGGH---RAQA 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + A + D++ R++ A +V + +PA V + + APLPF+L LQ+ Sbjct: 233 RLVVATDAPLDDKNRIIDEVYATNVADACRQKPAAVIEARVEEKQTPAPLPFALLDLQVY 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 +K + A+ L + Q L E +K ITY RSDC YL E F ++ +S PDL Sbjct: 293 MSKTHSIDAEKTLALTQALREKYKAITYNRSDCSYLTAEQFGEAPQTLSLLSEALPDLAG 352 Query: 361 QPV-VDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDA 418 V+ + ++R +DD KV AH AIIPTA + L+ +E VY I ++Y+ QF P+ Sbjct: 353 MFTEVNSERKSRAFDDSKVSAHTAIIPTAVKIDITQLSADERAVYMAIVKRYVAQFLPEK 412 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRT-LLGSKERDEENDGT--------PLPVVAK 469 + + + FVA++ + GW + E DE+ L + Sbjct: 413 RYLSAEVRFGVNGHTFVARSTKVTHPGWTAQVTEENEPDEDGSDAAEVASPFDALAGLKV 472 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR--------ATDG 521 GD +C+ V + +T+P +T+A LL + +A++V+D +K++L G Sbjct: 473 GDAGVCDGITVAKEKTKPLPLYTEAELLKDLRRVAKYVKDPRIKQLLIDRDQGKKGENGG 532 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 +GT ATR ++ L +RGF + + + T G +LP +AT PDMTA W I Sbjct: 533 IGTPATRGAVLAKLQERGFYAVEKKKLIPTALGLEFIAALPAIATTPDMTALWHEQQQMI 592 Query: 582 SEKQCRYQDFMQPLVGTLYQLID-------QAKRTPVRQFRGIVAPGSGGS 625 + F+ L + + Q PV P G Sbjct: 593 EAGELTVDAFLDELEAFIADQVQNIDLGNVQGDGKPVLDSLNAQCPMCGSD 643 >UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP3_BACSK Length = 729 Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats. Identities = 201/635 (31%), Positives = 317/635 (49%), Gaps = 35/635 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 + +AEKPS+AR IA VL ++KG+G++E GNG ++TW +GHL+ A P+ Y +Y W Sbjct: 4 KAVLAEKPSVARDIARVLG-CNQKGNGYLE-GNGYIITWALGHLVTHADPEHYGKQYKTW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 L +LP++P++ +L KQ + +K L+ E+V A D REG+L+ +L+ Sbjct: 62 KLEELPMLPKRLELVVIKQTAKQFHAVKHVLNRQDVGEVVIATDAGREGELVARWILEKA 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ V+R I+ + +A++ +L+ + L +A ARA ADW GIN TRA Sbjct: 122 HV----KKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAAAARAEADWYVGINGTRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T + LS GRVQTP L ++ R+E I FV K + + + T Sbjct: 178 LTT-----KHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISV----ETKDGVTFR 228 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + +E R+ A+ + ++ ++ S N K + P + L+ LQ Sbjct: 229 WADRRS------KEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYDLTELQR 282 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA KRFG SA+ L Q+LYE HK +TYPR+D RYL + ++A+ V + Sbjct: 283 EANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDVQPFRKM 342 Query: 360 PQPVVD---PDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFC 415 + + + +D KV HHA+IPT + SA +++ EAK+Y+LI R++L F Sbjct: 343 VANAKKQGLANAKRQMVNDAKVSDHHALIPTEQPQSASAMSDKEAKLYHLIVRRFLANFF 402 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P + +E AK L AGWR ++E LP ++KGD+ Sbjct: 403 PPSESELTSVEATANGELLRAKGERLVSAGWRG--QETGEEDEALARLLPAMSKGDKKAV 460 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGIIE 533 + + + +T PP F + TLL+AM A+ ++ D+ +KK L G+GT ATRA IIE Sbjct: 461 KWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVATRADIIE 520 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LF ++ KKG+ ++ T GK L +P P +TA WE L +I + + + Q F+ Sbjct: 521 KLFSSFYIEKKGKDLYITSKGKQLLELVPAELKSPALTAEWEQRLEKIVQGKEQKQMFIA 580 Query: 594 PLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGG 624 + ++ Q K G P G Sbjct: 581 EMKEYAKAVVAQVKADTATFRHDNKTGEKCPECGK 615 >UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0_9FIRM Length = 703 Score = 549 bits (1416), Expect = e-155, Method: Composition-based stats. Identities = 207/653 (31%), Positives = 317/653 (48%), Gaps = 57/653 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS++RAIA+V+ R+ DG+++ G +V+WC GHL E PDAYD ++ + Sbjct: 1 MYLVIAEKPSVSRAIAEVIGAQERE-DGYLQ-GTDCMVSWCFGHLAEYVSPDAYDEKFNQ 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W++ Q ++KR L+ E +V+A D REG+L+ V D Sbjct: 59 WRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDL 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ L A+ + LRS E+ L +A+ R++ADWL G+N TR Sbjct: 119 SG----SKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT Y L+VGRVQTP L ++V R +I NF + +F V+ Sbjct: 175 AYTT-----KYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELD----------- 218 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 C+ + ++ AE + +R G AIVT+ + + AP + L+ LQ Sbjct: 219 -------CDGIPAVKPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTLQ 271 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA + +G++A+ LD Q LYE KLITYPR+D +YL E+ V+ I Sbjct: 272 REANRIYGMTAKQTLDTAQSLYE-KKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLT 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE---NEAKVYNLIARQYLMQFC 415 P + + ++ KV HHAIIPT ++ +L E E K+ LIA +M Sbjct: 331 GPFDQPEQPDVKKVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLIAVHTVMAMS 390 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE--------RDEENDGTPLPVV 467 D ++++ IE++ + F AK + + + GW+ + ++ +P V Sbjct: 391 KDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPKV 450 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G E E T PP+ +++ TLL+AM D+D GLGT AT Sbjct: 451 TQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDT-----EKKGLGTPAT 505 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RAGIIE L + T+KG+ I TD GK L LP+ MTA WE+ L + + Sbjct: 506 RAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQLLLMEHGEIA 565 Query: 588 YQDFMQPLVGTLYQLI--------DQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 + FM + L ++ ++ +R R+ G P G + K Sbjct: 566 PEQFMTGIKNMLTMMLNGCDAISEEETRRFQTRESIG-TCPVCGSLVYESKTN 617 >UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0YH06_9FLAO Length = 695 Score = 548 bits (1413), Expect = e-154, Method: Composition-based stats. Identities = 202/643 (31%), Positives = 312/643 (48%), Gaps = 49/643 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+ IAEKPS+AR IA +L H K DG++ GNG VTW +GHL+ P+ Y R Sbjct: 1 MKAIIAEKPSVAREIAQLLG-AHEKKDGYL-SGNGYCVTWALGHLISLGMPEDYGIR--G 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + A LPI P + L P+ PS KQLN I++ + + S I+ A D REG+ Sbjct: 57 FKKASLPIFPNPFILTPKKLKKAKGYEPDPSALKQLNTIQQVIKQCSSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YLQ + +R I+ L +A++ L+ F L +A AR+ AD Sbjct: 117 LIFRYIYHYLQC----NKPFERLWISSLTEKAIQDGFKNLQPGDAFDGLYQAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A TI G Q V S+GRVQTP L L+ +R + +NF + +F+++ Sbjct: 173 WLVGINATQALTI----GGNQDVYSLGRVQTPTLALICQRFLQHQNFTKQKYFQIQLSHR 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 + + Q EE + AE + I + AIV + K E + Sbjct: 229 KE--------YTDFTSLSLLQWEE-----KKQAEQIQKIIEREGRAIVEDVSVKTVQEQS 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL F L+ LQ EA ++ GLSA VL Q LYE ITYPR+ +Y+PE+ + ++ Sbjct: 276 PLLFDLTELQKEANRKLGLSADEVLQTAQSLYEKQ-FITYPRTGSKYIPEDLWTDIPELV 334 Query: 349 NAISVHAPDLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 ++ P + + R +D KV HH ++ T ++ + L+ E +Y++IA Sbjct: 335 RILNQTEPFKAAITHLKFGNFNKRIVNDVKVTDHHGLLITTKTPSA-LSATEKAIYDMIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE-----ENDGT 462 + L + I++ + +F K + GWR + G +E D T Sbjct: 394 YRLLESLSHTCTKQVTQIQIKVHHYEFQIKGSKILNKGWRAIKGILSDNENSNNANEDLT 453 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP GDEL K E++E+ TQPP+ +T+A LLS M R +++K+ +K L + G+ Sbjct: 454 ELPEFKIGDELKISKTELLEKTTQPPKLYTEADLLSVMENAGRSIENKEDQKAL-SNIGI 512 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQI 581 GT ATRA IIE L R ++ +K + +H TD G +++ + + MTA WE L +I Sbjct: 513 GTPATRASIIETLLSRNYIVRKSKTLHPTDKGLQVYNLVKDKKIANVQMTAEWEIALDKI 572 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKR--TPVRQFRGIVAPGS 622 + + FM + ++ + P + P Sbjct: 573 EKGELNKTQFMNDIQAYTAEITSELLSLHIPQENIPQLKCPKC 615 >UniRef50_Q312M7 DNA topoisomerase n=1 Tax=Desulfovibrio desulfuricans subsp. desulfuricans str. G20 RepID=Q312M7_DESDG Length = 805 Score = 548 bits (1412), Expect = e-154, Method: Composition-based stats. Identities = 218/707 (30%), Positives = 330/707 (46%), Gaps = 95/707 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-R 60 L IAEKPS+AR IA L + DGF+E G +V+W +GHL+ A+P+ D + R Sbjct: 4 ILIIAEKPSVAREIAP-LVGAVSRRDGFLE-GPTHIVSWAVGHLVNIAEPEEQDEAWGGR 61 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W L LP++P +++L P +Q +++ +H +V+A D REG+L+ + Sbjct: 62 WALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRI--- 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 QL + VQR ND+ + + R++ L ++ L ++A ARA ADWL G+N++R Sbjct: 119 -QLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSR 177 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---------- 228 +T+ ++SVGRVQTPVL L+ R EIE+FV DF+ V+A Sbjct: 178 LFTLKA-----GSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGG 232 Query: 229 ----------------------VTPADERFTAIWQPSEACEPYQDEEGR-LLHRPLAEHV 265 + A +C P ++ + R A+ V Sbjct: 233 AAAAAGSAAPVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDV 292 Query: 266 ---------------VNRISGQPAIV---------TSYNDKRE-SESAPLPFSLSALQIE 300 + R A++ + R+ S+ PLPF L+ LQ E Sbjct: 293 FSAVWHLPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQRE 352 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA-ISVHAPDLL 359 A RFG SA+ L I Q LYE KLITYPR+D RYL + F A ++ + + Sbjct: 353 ANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETV 412 Query: 360 PQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 P V + C +DKKV HHAIIPTA + L+ E VY+++ R+++ F Sbjct: 413 PAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAP 472 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEK 477 A F + + + FVA+ + + GW + + ++ PLP + KG L + Sbjct: 473 ASFMSSTVRVLSGEDVFVARGKVFKDIGWLAVEPWRTAED----NPLPALRKGTRLHVHE 528 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 V RQT+ P HFTDA+LL+AM R V D++L+ ++ GLGT ATRA IIE L Sbjct: 529 VSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKE-RGLGTPATRAQIIETLLA 587 Query: 538 RGFLTKKGRYIHSTDAGK---ALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 RG++ KKG+ + +TD+G AL S+ ++T WE L I Y FMQ Sbjct: 588 RGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQE 647 Query: 595 LVGTLYQLIDQAKRTPVRQFRGI------------VAPGSGGSADKK 629 + L Q ++ K V+ P G +++ Sbjct: 648 IRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEER 694 >UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_SORC5 Length = 1476 Score = 546 bits (1408), Expect = e-154, Method: Composition-based stats. Identities = 210/731 (28%), Positives = 325/731 (44%), Gaps = 106/731 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKP++AR IA VL ++ +GF+E G G VVTW IGHL+ A+P D + R Sbjct: 1 MIAVVAEKPAVARDIAAVLG-ASKRAEGFLEGG-GYVVTWAIGHLVAIAEPHQIDPAWKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W L LP++P ++ L P Q ++++ L + +V A D REG+L+ + + Sbjct: 59 WRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEA 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ L P A+ + RLR + L +A R+RADWL G+N++R Sbjct: 119 AGC----KKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-------- 230 AY+++ + LSVGRVQTP L +VV R+ I FV + + EV A Sbjct: 175 AYSLV-----FDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGA 229 Query: 231 --------------------PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS 270 A ER A +P+ P E RP A Sbjct: 230 ADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAP 289 Query: 271 GQ--------------------PAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQ 310 + A + + + PL + L+ LQ A + +G SAQ Sbjct: 290 SRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQ 349 Query: 311 NVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRN 370 L++ Q LYE KLI+YPR+D R+L E A A + AI +L + Sbjct: 350 KTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGK 409 Query: 371 RCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI 429 R DD KV HHAIIPT RSS L+ +E K+++LI R+ L + D V + I Sbjct: 410 RFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAI 469 Query: 430 AK-------------GKFVAKARFLAEAGWRTL-------------------LGSKERDE 457 ++ + + + GW+ L G D Sbjct: 470 TTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDA 529 Query: 458 EN-----------DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 + D P +A+G L E ++T+PP FT+ATLL+AM Sbjct: 530 RDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSS 589 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT 566 +++K+L ++ + GLGT ATRA IIE L +R ++ +KG+ +H+TD G L + Sbjct: 590 LEEKELSAAMKDS-GLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVK 648 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 P MT WE+ L +++ FM + + Q++ + G ++P +G S Sbjct: 649 SPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASP 708 Query: 627 DKKKAAPRKRS 637 +++ R R+ Sbjct: 709 FQERGEARSRA 719 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 545 bits (1405), Expect = e-153, Method: Composition-based stats. Identities = 189/621 (30%), Positives = 308/621 (49%), Gaps = 30/621 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFI------ECGNGQVVTWCIGHLLEQAQPDAY 54 M + +AEKP AR +A P PH KG+GF+ E NG VTW IGHL+E +P+ Y Sbjct: 1 MIVILAEKPDQARKLAS--PFPHTKGNGFLSIQSCKEFPNGATVTWAIGHLVELKEPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+LA LPI+P +++ + KQ +K+ L EA EI+ A DP REG+ + Sbjct: 59 RPEWKKWDLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEIIIATDPAREGENIARL 118 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 ++ + +++++R + L A+ + L+ E + L A AR ADWL G+ Sbjct: 119 LILMAGCS---KKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHEAQARQIADWLVGM 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +R YT+L + G + V SVGRVQTPVL L+ R +EIE F + F+E++ Sbjct: 176 NASRLYTLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPFYELEGQFTVKNGT 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + + + + L+ ++ + A++ S + AP SL Sbjct: 236 YRGKLNKRFSSPDE--------LYEAVSPDITKEQQTYQAVIKSVRISEKRTPAPKLHSL 287 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S LQ + + S VL++ Q LYE ++YPR+D +Y+ EE + ++ Sbjct: 288 STLQSKLNRTKKFSPTKVLELVQSLYE-KGYVSYPRTDSQYITEEEYTYLQKHVDQYQQC 346 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN----LTENEAKVYNLIARQY 410 + P+ R + +KV H+AIIPT + + +E +VY I + Sbjct: 347 LG--IHVPIRSLQPSKRYVNPEKVSDHYAIIPTEKVPDTKAFETFSSDEKEVYYEILKSA 404 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT--PLPVVA 468 L F D V+ + VI + K +FV K R E GW+ L +++ +E LP V Sbjct: 405 LAMFMTDYVYDETVIITSVGKQEFVTKGRTEKEMGWKALYQNEKDEESEGEQVAILPEVK 464 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ V + TQPP+ +T L++ M ++V+D+++K+ L +GLGTEATR Sbjct: 465 EGESAKA-DISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALNQVEGLGTEATR 523 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCR 587 A II+ L +R + K + T G+ L ++ + ++P+MTA WE L +I + Sbjct: 524 AAIIDTLIQRRLIEVKKNQVFVTKKGEILCEAVKGTILSKPEMTAKWELFLQEIGKGNRS 583 Query: 588 YQDFMQPLVGTLYQLIDQAKR 608 + F++ Y LI QA + Sbjct: 584 KEVFIEQAKKLCYALIQQASQ 604 >UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9Z3_9FIRM Length = 707 Score = 545 bits (1404), Expect = e-153, Method: Composition-based stats. Identities = 192/627 (30%), Positives = 300/627 (47%), Gaps = 55/627 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 +L IAEKPS+AR+IA V+ K +G+ + G G +V+WCIGHL+ A+ YD +Y + Sbjct: 3 FQLVIAEKPSVARSIAAVIGAT-EKQNGYWQGG-GYLVSWCIGHLVSFAEAGQYDEKYCK 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ WQ +Q +++ L+ + + A D REG+L+ V Sbjct: 61 WRYEDLPILPQPWQFIVPDEKKQQFEIVRSLLNRPDVDSVTAATDAGREGELIFRFVYQM 120 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R I+ + A+ LR +S++ L SAL RA+ADWL GIN TR Sbjct: 121 AGCT----KPVKRLWISSMEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATR 176 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +++L Y L+VGRVQTP L ++V RD +I F + ++ V Sbjct: 177 LFSVL-----YHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQ----------- 220 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + R+ A + + +G A+ S ++++E P + L+ LQ Sbjct: 221 -------SGSLKADSERISDAEAANLLKEKCTGANAVCVSIRREKKTEQPPKLYDLTTLQ 273 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA + FG +A+ LD Q+LYE KL+TYPR+D +YL E+ +++ + P Sbjct: 274 REANRLFGFTAKQTLDYAQQLYE-KKLLTYPRTDSQYLTEDMGRTAQHLVSDLLGLLP-- 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTA---RSSAINLTENEAKVYNLIARQYLMQFC 415 Q + R + KKV HHAIIPT+ + L E+E K+ NL+ + L Sbjct: 331 FAQGLALTAEVGRVLNSKKVSDHHAIIPTSEFVKQGFTGLAESECKLMNLVCSKLLCAVA 390 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-------LGSKERDEENDGTPLPVVA 468 + A +F AK + + GW+ + L + +E LP + Sbjct: 391 APHEYETVTAVFSCAGNEFAAKGKTVLVPGWKEIDQRFRSTLKTDGEEETETLNTLPELT 450 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA--RFVQDK--------DLKKILRA 518 +G ++ E T PP+ +T+ TLLSAM +DK + Sbjct: 451 EGQNFSVTT-DISEHFTSPPKAYTEDTLLSAMERAGAEDMPEDKVNCSAGAREGGLGQAE 509 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 GLGT ATRA I+E L + GF+ +KG+ + T G L LPE T P +TA WE+ L Sbjct: 510 RKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPVLTAEWENRL 569 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQ 605 T+I++ +FM + + QL+ Sbjct: 570 TEIAKGNADPDEFMAEIEAQVRQLVKT 596 >UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM3_PAESJ Length = 770 Score = 544 bits (1403), Expect = e-153, Method: Composition-based stats. Identities = 218/673 (32%), Positives = 333/673 (49%), Gaps = 55/673 (8%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKP + R IA V+ ++E G+ ++TW IGHL+ A+PD YD+RY Sbjct: 1 MKTLIIAEKPDMGRTIAAVVEPKAANKRTYLE-GDRFIITWAIGHLVTLAEPDQYDARYK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 RWN DLPI+P+K++L P QL I +V+A D REGQL+ + YL Sbjct: 60 RWNDQDLPIIPDKFKLWPNARTKDQLKTIGELAKRCGRLVNACDAGREGQLIFHLIRQYL 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 +L Q R I+DL P+ + + D LRS+ ++ PL +A AR+ ADWL G+N +RA Sbjct: 120 KL----PQPTDRLWISDLTPETIRKGFDSLRSDEDYAPLTRAARARSEADWLIGMNASRA 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +TI ++ +LSVGRVQTPVL L+ R +EI F + ++ VKA + ++ I Sbjct: 176 FTIR-----HKALLSVGRVQTPVLALLYDRHKEITAFKSDMYYVVKALFDQNGFQ-YSGI 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 WQ R+ + AE + + G+P + Y E L+ LQ Sbjct: 230 WQGD-----------RITDKAKAEALAAKTQGKPGFIKDYQTAESKEYPFRLHDLTLLQR 278 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA R+G SA+ LDI Q LYE HK ITYPR++ Y+ EE+ V+ + Sbjct: 279 EANGRYGYSAKKTLDIAQALYEKHKAITYPRTNSNYVTEENLPVMQKVLTMLQGSDSYRE 338 Query: 360 PQPVVD----PDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 D + KV+ HHAI+PT + + L+ E +Y++I R++L Q+ Sbjct: 339 LANGADRGRVHKGNKAVCNPSKVEDHHAIMPTPKRPS-GLSPEEQNIYDMIVRRFLSQYY 397 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------------------GSKERDE 457 P AV++ + ++ F KA+ L E GW+ +L E D+ Sbjct: 398 PPAVYKNHTVLTEVESEIFRTKAKELLELGWKVVLQDQGQAAKKTSKKKSSEKDEAESDD 457 Query: 458 ENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 E T P + + C K E +E+ TQPP+ FT+ TLL AM + ++D +L++ + Sbjct: 458 EELLTDKPFAIEPQQGVKCVKSESLEKTTQPPKSFTEGTLLKAMESAGKSMEDDELREAM 517 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTA 572 + T GLGT ATRA IE L + G++ G+ + + G A + ++ P+MT Sbjct: 518 KDT-GLGTPATRAATIERLKQVGYVDLTGKKLEISSKGCAAIELIRGAGVDLLASPEMTG 576 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 WE L QIS + F+ + ++D+ ++ SGG K+ AA Sbjct: 577 RWEQRLHQISRGEASDDQFIMKVKQFAAMIVDKVRQQRPAAPGTFEERESGG---KRGAA 633 Query: 633 PRKRSAKKSPPAD 645 KR ++ S P+ Sbjct: 634 GTKRGSRTSKPSG 646 >UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actinomycetemcomitans D11S-1 RepID=D0UIR3_AGGAD Length = 760 Score = 543 bits (1400), Expect = e-153, Method: Composition-based stats. Identities = 218/665 (32%), Positives = 352/665 (52%), Gaps = 21/665 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKP LA+ IA+ + +RK G+ EC N VVT IGH+L Q P+ + +Y Sbjct: 1 MKLIIAEKPQLAQVIAEAIGIINRKT-GYFECNNNYVVTNAIGHILMQKMPEEINEQYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L DLP+ L+ +P +Q V++ L +A +++AGDPD EGQLLVDE++++ Q Sbjct: 60 WRLEDLPLQVRPIPLKVKPQTAEQFKVVQGLLAQADTVINAGDPDDEGQLLVDEIIEFCQ 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + QR L+NDL ++ ++A+ + NS+++ + ALAR++AD+++G+N+TRAY Sbjct: 120 FKGVQ----QRLLVNDLKVESAKKALANIEPNSKYLGMRNKALARSQADYIFGLNLTRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TI R G + L VGRVQTP L LVVRR + + ++ V + F A Sbjct: 176 TIFARKKGIKNALMVGRVQTPTLALVVRRFLQNRDHKESYYYNVGGNFTF-NQTSFNAKL 234 Query: 241 QPSEA--CEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +E +P ++E R++ +A + + +++ + ++ SAPLPFSL LQ Sbjct: 235 VLTENIPTDPNNEKEKRIIEEAVANGIKTACEAKNVTLSTVTIEDKTTSAPLPFSLLDLQ 294 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++G S+ VL I Q L E HK ITY RSDCRYL ++ F ++ ++ P+ Sbjct: 295 VRLNNKYGFSSDKVLKITQDLREKHKAITYNRSDCRYLTDDQFNEAPQTLDFLTDLFPE- 353 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIP-TARSSAINLTENEAKVYNLIARQYLMQFCPD 417 LP+ +D + R ++ KV AH AIIP T + + T++E KV+ IA QY +QF P+ Sbjct: 354 LPKEQIDKTKKGRAFNANKVTAHTAIIPVTGKYQLNDFTQDELKVFTEIATQYFIQFLPE 413 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVVAKGDELLC 475 +++ + +F A GW L+ + +EEN D L + + + C Sbjct: 414 KSYQQVTAIVACNGYQFKTTATKTLNHGWSKLVADDDVEEENQSDFEQLASLTEQAQGQC 473 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR--------ATDGLGTEAT 527 + E+ + +T+P +T+ATLL + I+++V+D D+KK+L G+GT AT Sbjct: 474 NRIEIKKEKTKPLPIYTEATLLKDLQNISKYVKDPDIKKLLIDKDKGKDGENGGIGTPAT 533 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 R+ II+ L G++ +G+ I TD SLP++ T PDMTA W +I + Sbjct: 534 RSAIIKKLVDTGYIEYQGKKILPTDLAIDFIGSLPDIITYPDMTALWFEQQREIEQGNLS 593 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 F+ + + + I QA+ V + +G G +K + S P +V Sbjct: 594 VNSFLDRIEKFVMEQIKQAENLKV-ELKGEPCECGKGVLILRKTDKGTFFSCSSYPECKV 652 Query: 648 GSGAI 652 A+ Sbjct: 653 IKPAL 657 >UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C0FPK2_9FIRM Length = 680 Score = 543 bits (1400), Expect = e-153, Method: Composition-based stats. Identities = 201/648 (31%), Positives = 301/648 (46%), Gaps = 60/648 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPS+A++IA VL R DG++E G G +V+WC GHL E A Y++ A+ Sbjct: 1 MRLVIAEKPSVAQSIAAVLGAKSR-HDGYLEGG-GYIVSWCFGHLAELADAAVYNAVDAK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W LA LPI+P ++ R KQ ++++ + E+V+A D REG+L+ V Sbjct: 59 WTLAALPIIPTSFRFIVRSEKQKQFDILRELVRREDVAEVVNACDAGREGELIFRTVY-- 116 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + R I+ + A+ +LRS ++ L SAL RA+ADWL GIN TR Sbjct: 117 --CLAGCSKPILRLWISSMEDDAIRSGFQQLRSGRDYDGLHQSALCRAKADWLVGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++++ Y L++GRV +P L L+V+R+ EI FVA+ F+ V+ PA Sbjct: 175 YFSLM-----YGRTLNIGRVMSPTLALLVQREAEISAFVAEPFYTVQLDCGFPATT---- 225 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 R+ R A+ + N G+ V S K +SE AP + L++LQ Sbjct: 226 ---------------DRMKDRKDADAIANACKGKTVTVKSVERKEKSEKAPALYDLTSLQ 270 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +A + G ++Q LD Q LYE KL TYPR+D YL ++ ++ A + Sbjct: 271 RDANRVLGYTSQQTLDYLQALYE-KKLCTYPRTDSHYLTDDMEGSVPGLVAAAAAACGVE 329 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQFC 415 P + + KKV HHAI+PT + ++ L E +V L A+ L Sbjct: 330 KPPTICA----KQVCSSKKVTDHHAIVPTISAEKVDMASLPLGEREVLKLAAKGLLRAVD 385 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 + + VI +D A F AK + + GW+ E+++ LPV + L Sbjct: 386 EPHRYAETVITVDCAGQSFTAKGKTVLAPGWKRY----EQEQTEAVPALPVATENQTLSV 441 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 V +T PP+HFT+ TLL+AM + D G+GT ATR+GIIE L Sbjct: 442 SAASVKTGKTTPPKHFTEDTLLAAMENAGKEDMPDDA-----ERKGIGTPATRSGIIEKL 496 Query: 536 FKRGFLTKKGRY----IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 GF+ ++ + T G AL LPE P +TA WE L +I + F Sbjct: 497 VSSGFVERRKSKKITNLLPTSTGTALITVLPEQLQSPQLTAEWEHRLKEIERGEIAPDSF 556 Query: 592 MQPLVGTLYQLIDQAKRTPVRQFRGI-------VAPGSGGSADKKKAA 632 M + L +L+ K P + P G + + Sbjct: 557 MDGIAAMLNELVQTYKPIPGAEVLFPSGREVVGKCPRCGAEVTESQKG 604 >UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 Tax=Campylobacter RepID=A7HZT1_CAMHC Length = 716 Score = 543 bits (1399), Expect = e-153, Method: Composition-based stats. Identities = 205/660 (31%), Positives = 341/660 (51%), Gaps = 42/660 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP+LA++IA + ++ GDGF + G ++TW GHLLE P+ YD + + Sbjct: 1 MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGEN-IITWAFGHLLELYMPEDYDENFKK 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W+L DLP+ ++++ +P S +QL +I + + I++ GD D EGQ+L+DE+L Y Sbjct: 60 WDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKRSDVDTIINCGDADEEGQILIDEILKY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V R L++DL + V + ++SN++F L AR+ ADW+ GIN+TR Sbjct: 120 ----ANNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINLTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT +N GY+GV+SVGRVQTP+LGLVV RD E E + ++ + T E Sbjct: 176 AYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEILAN 235 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + ++ A + N G+ + + ++ + E PLP++L LQ Sbjct: 236 L-----------KTDEKITDENEANEIKNICLGKNG-ILNVTNENKLEYPPLPYNLLNLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + +K+F L I Q L E +K ITY RSDC YLP + V+N+I + D Sbjct: 284 ADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLSDF 343 Query: 359 LP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 DP++++R ++D+ + AH AIIPT + N ++++E VY LI+++Y+ QF Sbjct: 344 ENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIAQFYE 403 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------GSKERDEENDGTPLPVVAKG 470 + + IE+ I KF + + + G+ +L K DE + L ++ G Sbjct: 404 PMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDDEVENSFDLSLLESG 463 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK--------KILRATDGL 522 E+ ++QT+P ++T TLL +T I+++V+D+ +K G+ Sbjct: 464 -NCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKKGENGGI 522 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQIS 582 GT ATR+ I+ LF+R ++ ++ + I ST G+ L P++ + PDMTA W +I Sbjct: 523 GTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYEQQLEIQ 582 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGI----VAPGSGGSADKKKAAPRKR 636 DF+ + + + I+ K + + F GI G K+ + + Sbjct: 583 NGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGIDKTYPCKCGKGFLQKRHSQKTGK 642 >UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D1W4E5_9BACT Length = 714 Score = 541 bits (1395), Expect = e-152, Method: Composition-based stats. Identities = 197/639 (30%), Positives = 304/639 (47%), Gaps = 49/639 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+ IAEKPS+AR IA ++ R+ +G+ E G G VTW GHL++ A PD Y R Sbjct: 20 MKTIIAEKPSVAREIARIVGATKRE-EGYFEGG-GYAVTWAFGHLVQLAMPDGYGVR--G 75 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + +LPI+P+ + L PR V Q+ VIKR + I+ A D REG+ Sbjct: 76 FVRDNLPIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDTSEHIIVATDAGREGE 135 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + Y R I+ L +A+ + +L S++ L ++A AR+ +D Sbjct: 136 LIFRYLYHYTGCTT----PFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKARSESD 191 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A +I A G SVGRVQTP L +V R E F ++ F+ + HI Sbjct: 192 WLVGINGTQALSI----AAGHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLL--HIA 245 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 T + + SE + + A + N++ A VT K ++E Sbjct: 246 TDGCDGEVVKFSSSE----------KWKEKEPAMELYNKVKAAGCATVTKAERKEKTEET 295 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA + G +A+ L+I QKLYE KLITYPR+ RY+PE+ FA ++ Sbjct: 296 PLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYE-KKLITYPRTGSRYIPEDVFAEIPKLL 354 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 I P+ + R DD KV HHA++ T L++ + +Y +IA Sbjct: 355 AFIGTQ-PEWKDKVRAKAAPTRRSVDDGKVTDHHALLVTGEKPLF-LSKEDNTIYQMIAG 412 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + F V + + A +F K + + GWR + G EE + +P Sbjct: 413 RMVEAFSEKCVKDVTTVTAECAGVEFTVKGSVVKQTGWRAVYG-----EEKEEITIPGWQ 467 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GD L + + E +T+P T+ATLLSAM + ++D L++ ++ G+GT ATR Sbjct: 468 EGDTLTPKGSSITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATR 526 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQCR 587 A IIE LFKRG++ + + + T+ G AL + M MT WE L +I + Sbjct: 527 ASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWEKELARIERGELS 586 Query: 588 YQDFMQPLVGTLYQLIDQA---KRTPVRQFRGIVAPGSG 623 F + + ++ + + + G P G Sbjct: 587 ADTFRKEIEAYTREITSELLSCDKLFGSRDSGCACPKCG 625 >UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1_CLOD6 Length = 696 Score = 541 bits (1393), Expect = e-152, Method: Composition-based stats. Identities = 191/649 (29%), Positives = 305/649 (46%), Gaps = 60/649 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS+A+ IA VL +K DGF+ G+G +V+WC+GHL+ A+ AY +Y + Sbjct: 1 MILVIAEKPSVAQTIAAVLGVKEKK-DGFL-TGSGYIVSWCVGHLVGLAEAAAYGEQYKK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 WN LPI+P++W+ KQ +K +H A E+V+A D REG+L+ V + Sbjct: 59 WNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEM 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ ++R I+ + A++ RL++ E+ L SAL RA+ADWL GIN TR Sbjct: 119 AGC----KKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +++L Y L+VGRVQTP L ++V RD I F + ++ V+ + Sbjct: 175 LFSVL-----YNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAAS--- 226 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 R+ ++ A+ + A+ TS ++++ + P F L++LQ Sbjct: 227 ---------------ERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQ 271 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA FG +A+ LD+ Q LYE L+TYPR+D YL ++ ++ + P + Sbjct: 272 REANCLFGYTAKQTLDLAQALYEKR-LLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFM 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL---TENEAKVYNLIARQYLMQFC 415 + + + KKV HHAIIPT + +L E+E + + + +M Sbjct: 331 AGKDFTPELAK--VLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATA 388 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL----------GSKERDEENDGTPLP 465 F + A F A+ + + GW+ + + + + LP Sbjct: 389 APHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLP 448 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 +G +V E T PP+ +A+LLSAM D D GLGT Sbjct: 449 PFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDA-----ERKGLGTP 503 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ 585 ATRA +IE L K GF+ +KG+ + T G L LP+ T P +TA WE+ LTQI++ + Sbjct: 504 ATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGK 563 Query: 586 CRYQDFMQPLVGTLYQLID------QAKRTPVRQFRGI--VAPGSGGSA 626 FM+ + +L+ +A + ++ + P G Sbjct: 564 ADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPV 612 >UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q185E5_CLOD6 Length = 706 Score = 539 bits (1389), Expect = e-151, Method: Composition-based stats. Identities = 192/632 (30%), Positives = 313/632 (49%), Gaps = 47/632 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L +AEKPS+ R IA VL + K +G+IE G V+TW +GHL+ A P++Y RY W Sbjct: 4 ILVLAEKPSVGRDIAKVLGSKNEK-NGYIE-GPKYVITWALGHLVTLADPESYGERYKSW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 +L DLPI+P+ + KQ N +K ++ + EIV A D REG+L+ +++ Sbjct: 62 SLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIEKS 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 Q+ ++ ++R I+ +A++ +L+S E+ L SA+ARA ADW+ GIN TRA Sbjct: 122 QV----KKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T Y LS GRVQTP L ++++R+EEI NF K+++ ++ I T + I Sbjct: 178 LTT-----KYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLEL-IATKGNSDIKFI 231 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W ++ + E + ++ G ++ N + + +P + L+ LQ Sbjct: 232 WND-------KNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQR 284 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A K FG SA+ L I QKLYE HK++TYPR+D RYL + + A+++ + Sbjct: 285 DANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKI 344 Query: 360 PQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCP 416 ++ +I D+ KV HHAIIPT + + ++ E K+YNL+ +++L P Sbjct: 345 CNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSP 404 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 + + I + F AK + GW+ K+ ++E++ +P V + D L + Sbjct: 405 PFEYEQTTISATVEGEIFKAKGNKVINLGWKESY--KDIEDEDEYESIPNVLEKDVLKVK 462 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 ++ +T PP + + TLL+AM +GLGT ATRA IIE LF Sbjct: 463 GLKITSGKTNPPPYLNEGTLLTAMEK-----------------NGLGTVATRADIIEKLF 505 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + KK + I+ T G+ L +P P++TA WE L IS+ + F+ + Sbjct: 506 NSFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMK 565 Query: 597 GTLYQLIDQAKRTPVR----QFRGIVAPGSGG 624 ++ + K + + P G Sbjct: 566 DYSKDIVLEVKNSDNKFKHDNLTKNRCPECGK 597 >UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_OENOB Length = 722 Score = 537 bits (1384), Expect = e-151, Method: Composition-based stats. Identities = 202/661 (30%), Positives = 336/661 (50%), Gaps = 29/661 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECG-----NGQVVTWCIGHLLEQAQPDAYDSR 57 + +AEKPS AR+ + L K K +G+ N +T+ GHL+E A P+ YD + Sbjct: 4 VILAEKPSQARSYVEAL-KNSTKKEGYFSVSDPVLANETFITYGFGHLVELATPEKYDQK 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 Y RW+L++LPI P+K++ Q ++K L +A I+ A D DREG+ + +++ Sbjct: 63 YKRWSLSNLPIFPDKYKFIVPRDKKTQFKIVKDLLMKADTIIIATDSDREGENIAWSIMN 122 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++ K + ++R IN L A+ L+ + P A R +DWL G+N + Sbjct: 123 QAKINL-KSKTIKRLWINSLEKDAILNGFKNLKDAWNYYPAYQEAQTRQISDWLVGMNGS 181 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 YT+L R +G +GV S+GRVQTP L +V +RD+EI+NF + +FE+ A I ++F Sbjct: 182 PLYTLLLRQSGVRGVYSIGRVQTPTLYMVYQRDQEIKNFKPEPYFEISAEIE-ANRQKFV 240 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A P + ++DEE ++ E R Q A+ + + ++P FSLS+L Sbjct: 241 AKLDP---YQRFKDEESLTIY---MEAKGLRTGFQEALTKDVLQETKRTASPRLFSLSSL 294 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q KR+ SA +VL Q LYE KL+TYPR+DC Y+ ++ F+ + N + + Sbjct: 295 QSAINKRYHASASDVLKAVQALYEA-KLLTYPRTDCNYITDQEFSYL--LSNLMGYLSLV 351 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA----RSSAINLTENEAKVYNLIARQYLMQ 413 + + + R + KKV HHAII T ++ L + + +VY L+ R L Sbjct: 352 SSQVSLNNTEANKRYVNSKKVQEHHAIIMTKTIPNKAKLAALPKLQQQVYGLVLRTTLAM 411 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F + + +I ++ K F A + GW+ L + + LP V K ++ Sbjct: 412 FADPYEYEQTIIITEVGKANFKATGNVPIKQGWKLLFADDKDKNDETVVTLPKVTKNQKV 471 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + +++T PP FT+ TL++AM R + D++ + IL+ +G+GTEATRA ++E Sbjct: 472 QA-DLKTPQKETTPPVPFTEGTLITAMKTAGRTLDDEEAQSILKDVEGIGTEATRANVLE 530 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHS--LPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 +L KRG+L K +H ++ G L + L + T P+MTA WE L +IS+K+ + F Sbjct: 531 VLKKRGYLLSKKNQLHVSEQGITLCTAVELEPLLTSPEMTAKWELALKEISQKKRSQESF 590 Query: 592 MQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + + + +L+D+ T ++Q G+ S ++K + R + G Sbjct: 591 LIQIKKFVSKLVDEVP-TQMKQSEGL----SKQVKNQKIVEIQDRQQEAIGRCPLCKEGM 645 Query: 652 I 652 I Sbjct: 646 I 646 >UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein n=2 Tax=Pedobacter RepID=C6XWV5_PEDHD Length = 608 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 188/637 (29%), Positives = 324/637 (50%), Gaps = 49/637 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+ R +A V +K DG+IE G G TW GHLL+ A P Y + Sbjct: 1 MKIVIAEKPSVGRELAKVFGATTKK-DGYIE-GKGYSFTWAFGHLLQLAPPQEYG--FIG 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 W LP++P+K++L R P V KQL++IK+ EA+EI+ A D REG+ Sbjct: 57 WRRQHLPMLPKKFKLAIRKIKTKDGMVEDPGVRKQLDIIKKLFDEATEIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L+ ++ +R I+ +A++ L+ +++ L SA R+ +D Sbjct: 117 LIFRYIYYFLKC----KKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N T+A +I +AG + VLS+GRVQTP L ++ R EI+NFV + ++++ + Sbjct: 173 WLVGMNATQALSI---SAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQLD 229 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS------GQPAIVTSYNDKR 283 + F A+ + + AE ++ +I + S K Sbjct: 230 KDG-QLFRAMSVSN------------FDKKEEAEELLAKIEDVASGFSNGGKILSVEAKP 276 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 E PL LS+LQ EA KR G +A L + Q LYE+ KL+TYPR+ RY+ ++ FAG Sbjct: 277 RKEPPPLLHDLSSLQQEANKRKGFTADQTLSLLQGLYES-KLVTYPRTGSRYIGDDIFAG 335 Query: 344 RHAVMNAISVHAP-DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 A+++ + H + ++ + R + KKV HHAI+PT S L ++ V Sbjct: 336 VPALIDKVRGHKDFGKQAEFLLTVPLNKRSVNAKKVTDHHAILPTGESP-YQLNGDKQAV 394 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 Y+++ + + F + V I ++ F+A + AGWR++ + +++++ Sbjct: 395 YDMVVGRMIEAFHQECVKEITKISVESGS-LFIANGTVIRAAGWRSVFNESDEEKKDEDN 453 Query: 463 P-LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 P LP + KG+EL ++E+QT+P + +A+LL A+ + ++D++L+ ++ + G Sbjct: 454 PALPKLKKGEELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDS-G 512 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQ 580 LGT ATRA IIE L R +++++ R + T G A++ + + + ++T WE L + Sbjct: 513 LGTPATRAAIIETLISREYVSREKRNLVPTTKGLAVYDVVKDQKIAQAELTGQWEKRLEE 572 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI 617 I DF + + ++ + I Sbjct: 573 IRSG-ASVSDFKAEIADYTKTITNELLAAGLTLAEKI 608 >UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacterium spiritivorum ATCC 33861 RepID=C5PM09_9SPHI Length = 704 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 187/676 (27%), Positives = 328/676 (48%), Gaps = 54/676 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR +A V+ DG+I GNG T+ GHL++ P AY + Sbjct: 1 MKVVIAEKPSVARDLARVMGAK-EVNDGYI-SGNGYAFTYAFGHLVQLCTPQAYG--FHT 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 W++++LPI+P +++L+ + KQLN IK L +A E++ A D REG+ Sbjct: 57 WSVSNLPIIPAQFKLESKKVKKDGKQMDDGGALKQLNTIKGLLDKAEEVIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL +R I+ +A++ L+ SE+ L +SA +R+ +D Sbjct: 117 LIFRNIYYYLG----ANVPFKRLWISSQTDKAIKEGFANLKEGSEYDSLYMSARSRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ AG +G+LS+GRVQTP L ++ R E +NF F++++A Sbjct: 173 WLIGINATQAITLA---AGNRGLLSLGRVQTPTLAMICSRFIENKNFKPTAFYKIQAQFE 229 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESA 288 ++ R+ + LAE + +I+ G A VT K E Sbjct: 230 KENI--------------KFKATSNRIDQKDLAEETLAKITVGASAKVTKVEGKEVKEPP 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ +A K++G SA L I Q LYE K+ITYPR+ RY+ E+ F + Sbjct: 276 PLLYDLTNLQQDANKKYGYSADQTLSIAQTLYE-KKVITYPRTGSRYIGEDVFEKIEELF 334 Query: 349 NAISVHAPD---LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 ++ A + + + ++ + R DDKKV HHA++ T + L + ++ +YN+ Sbjct: 335 QHLADTAEEGIATISRNLIGAKLNKRSVDDKKVTDHHALLVTDEKPSAML-KEQSNIYNM 393 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN------ 459 IA++ + F + + +D + +AK + + GWR E+ E++ Sbjct: 394 IAKRMVESFSDVCLKDITTVIMDAEGVELIAKGTVIKQYGWRLSADQLEQPEDDKKDNDD 453 Query: 460 ---DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 + LP ++ + L +++E+ T+ T+A+LL AM + + D ++++ + Sbjct: 454 ADTENAQLPKLSAEELLEILALDLMEKFTKAKPVHTEASLLKAMETSGKEIDDDEMRQAM 513 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWE 575 + GLGT ATRA IE LF+R ++ + + + TD G A+++ + + + ++T WE Sbjct: 514 KDC-GLGTPATRAATIETLFQRDYIRRDKKKLIPTDKGLAVYNLVKDRAIAKVELTGKWE 572 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSG-GSADKKKAAPR 634 L ++ + Y FM+ + ++ + + + + + P K Sbjct: 573 QKLEEMRANKVSYDVFMKHIKDFTVRITKELLQLRISLTQDVEPPKQTVSIKCPKCDKGS 632 Query: 635 KRSAKKSPPADEVGSG 650 +K D G Sbjct: 633 MILYEKVAQCDHYARG 648 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 536 bits (1381), Expect = e-150, Method: Composition-based stats. Identities = 179/678 (26%), Positives = 311/678 (45%), Gaps = 66/678 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IAD L ++K +G+IE +VTW +GHL+ A P+ YD+ Y Sbjct: 2 MKSLILAEKPSVARDIADALHIKNKK-NGYIE-NEKYIVTWALGHLVTNAAPEQYDASYK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 W L DLPI+P+ + +KQ ++K + + +I+ A D REG+L+ +LD Sbjct: 60 EWKLEDLPIIPKYMKTIVIGKTSKQFKIVKSLILDKKVKDIIIATDAGREGELVARLILD 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ +QR I+ + +A++ L+ + L +ALAR+ ADW+ GIN T Sbjct: 120 KVG----NKKPIQRLWISSVTKKAIQEGFKHLKDGRAYNSLYHAALARSEADWIVGINAT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS+GRVQTP + LV R ++I +F + ++ + + Sbjct: 176 RALTT-----KYDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYYTLSIKV--------- 221 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + E + + ++ E + ++ Q V K + ++L+ + Sbjct: 222 ------DGYEFTFNTQKHFKNKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQLYNLTDI 275 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-----S 352 Q +A +RF + + L+ Q LYE HK++TYPR+D YL + + + A+ Sbjct: 276 QQDAYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQALLATNYK 335 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 H +L+ Q + ++D KV HHAIIPT ++ L++ E K+Y LI ++L Sbjct: 336 SHVRELIGQSF---SPKMSIFNDSKVSDHHAIIPTEVRPSLEQLSQREFKIYMLIVERFL 392 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 + + ++ F K + G++ L +++ + G Sbjct: 393 ESLMKPYEYEGVTVNFEVGDLMFSLKENIPKQLGFKAL-----KEDTLQPSKSHQFVIGQ 447 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV--QDKDLKKILRATDGLGTEATRA 529 + +K ++ E +T+PP +F + +LL AM ++ +K + L+ T G+GT ATRA Sbjct: 448 QFKVQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTGGIGTVATRA 507 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 II+ LF L + I T GK + P T P +TA WE LTQI + + + Sbjct: 508 DIIDKLFNMNALEVRDGKIKVTSKGKQILELAPSELTSPLLTAQWEEKLTQIEKGRYNSK 567 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGG-----------------SADK 628 FM + ++ + K + + P G + K Sbjct: 568 KFMDEMKHFTKDIVQKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCK 627 Query: 629 KKAAPRKRSAKKSPPADE 646 K ++++ + P + Sbjct: 628 TKKNIQRKTNARCPNCKK 645 >UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum EbN1 RepID=Q5NX65_AZOSE Length = 634 Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats. Identities = 230/620 (37%), Positives = 333/620 (53%), Gaps = 30/620 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPSL +AIA+ LP + DGFI G VVTW GH+LE A P+AY+ + Sbjct: 1 MRLYIAEKPSLGKAIAENLPGVKSRDDGFIRVGTD-VVTWAHGHILELAPPEAYNPAWKS 59 Query: 61 WNLAD--LPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 WN A LP E ++L P+P QL VI+ L +A+E+V+AGDPDREGQ+L+DE+L+ Sbjct: 60 WNTAVNVLPYPIECFKLLPKPDSKAQLRVIQSLLSQATEVVNAGDPDREGQMLIDEILES 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + R LIN +P V++A+ +R NSEF L +A R+ ADW+ G+N+T Sbjct: 120 SAW----KGPTLRLLINATDPVTVKKALSSMRPNSEFFNLYQAAKCRSEADWIIGMNLTV 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A T L ++SVGRVQTP L LVVRRDE IE F A+ FF ++ + TP Sbjct: 176 AATKLL---ANDELVSVGRVQTPTLALVVRRDEAIEKFGARPFFSLEVTLETP-QGPIVL 231 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + PS DE R+ A+ +V + + ++ + + ES P F L Q Sbjct: 232 TYNPS-------DESKRIWSEVDAKRIVEEVKQRQSVTVTVTTGIKKESPPRLFMLRTFQ 284 Query: 299 IEAAKRFGLSAQNVLDICQKLYET-HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 E R+G SA L++ Q LY++ H+L +YPR+DC Y+P + I Sbjct: 285 GECNSRYGWSASKALELAQSLYDSKHQLASYPRTDCEYMPAGQANDALTIAQHIVKQTSF 344 Query: 358 LLPQPVVDPDI-RNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 P++ + R +D KV HHA+ PT +S+ LT +E K + L+A ++LM Sbjct: 345 TAFAPLLSLAVPRASIYDSSKVTEHHALTPTVKSADFKTLTADEQKAWLLLAERFLMSLL 404 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAE--AGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 P + V+ + +F AK WR L + PLP VA G L Sbjct: 405 PSHQIEETVVSFSHGEIEFSAKGEVSLNMAQSWRALAPHTYK-------PLPQVADGATL 457 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 VV+ +T PP+ +T+ TLL M+ +A++V+D LK IL+ T G+GT AT+A IIE Sbjct: 458 QMAGLRVVKGKTTPPKRYTEKTLLDDMSSVAKYVEDPKLKAILKETSGIGTAATQAKIIE 517 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L +RG++ K R + ST G+A+ H LPE T P +TA WE L I+ + D+M Sbjct: 518 TLKERGYVAVKNRELISTPFGRAVVHGLPERLTDPCLTALWEDALGLIAAGGMKPGDYML 577 Query: 594 PLVGTLYQLIDQAKRTPVRQ 613 + G QL+D + + ++ Sbjct: 578 RVRGMCKQLVDDVRDSVGKK 597 >UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9A9_9BACT Length = 645 Score = 534 bits (1377), Expect = e-150, Method: Composition-based stats. Identities = 236/620 (38%), Positives = 355/620 (57%), Gaps = 23/620 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+AR +A L ++G I+ NG +V W GHLLEQA+P AY ++AR Sbjct: 1 MRLYIAEKPSVARLLAATLGDGKQEGQ-HIKLTNGDIVAWAAGHLLEQAEPAAYGDQWAR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ LPI+P++W++ R V I+ L +A+E+V+ GD DREGQLL+DE+L + Sbjct: 60 WNIDSLPILPQQWKMNVRSEVKDLFKSIQGDLKDATEVVNVGDADREGQLLIDEILQRCR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LI D + A+ + N +A AR+RADWL+G+N TRA+ Sbjct: 120 ----YKGPVKRLLITDTTETGIRNALASMTPNEAHRGAAQAAQARSRADWLHGMNGTRAF 175 Query: 181 TILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L + GY+G L +GRV+TPV LVVRRD EIE+FV K ++ +KA + P+ ++A+ Sbjct: 176 TCLAQKGGYRGNALRIGRVKTPVTALVVRRDLEIEHFVPKPYWVLKAQVSVPS-GTYSAV 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W+P+E + D++ RL+ + + +V R++G A V S K PL +SL LQI Sbjct: 235 WKPTED-QVGLDDQNRLIDPTVRDDLVARLNGAKAEVQSVEVKHCKAVPPLGYSLPRLQI 293 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A+KRFGLS + L ICQ LYE ++TYPRSDC Y PE V+ A DL+ Sbjct: 294 DASKRFGLSPEATLKICQGLYEAQ-MLTYPRSDCVYAPEALKLSAEDVLLACGK-VTDLV 351 Query: 360 P--QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 + + W+ KV H+AI+PTA + L+ +E K+Y L+ +YL F D Sbjct: 352 GRFKGGLSLSRTAPVWNTAKVAEHYAILPTACPAPKALSSDEKKIYELVVTRYLAFFMSD 411 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS----------KERDEENDGTPLPVV 467 + + +I I F +K + + GW+ L K +EE + LP + Sbjct: 412 YEYEQTLIVTTIDGETFHSKGKRELQQGWKVLTAKVEDEDDSEEKKSEEEEEEDQALPEL 471 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +GD + ++++T+ P+ FT+A+LL+AM GI +FV ++KKIL+ TDG+GT AT Sbjct: 472 KQGDSGTA-SVQSLDKETKAPKRFTEASLLAAMNGIHKFVSSPEIKKILKETDGIGTAAT 530 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 +A II L G L K+ + I S+ + +AL +LPE T PDMTA WE Q+ + Sbjct: 531 QAKIIADLETSGLLIKEKKSITSSPSARALIAALPERITLPDMTALWEMKFRQLETGKAT 590 Query: 588 YQDFMQPLVGTLYQLIDQAK 607 ++ + + G + +ID+ K Sbjct: 591 FESVLDEITGEIVGMIDEVK 610 >UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C9LK04_9BACT Length = 705 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 193/656 (29%), Positives = 300/656 (45%), Gaps = 70/656 (10%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIEC---------GNGQVVTWCIGHLLEQAQPDAY 54 IAEKPS+AR IA ++ + K +G++ G+ VVTW +GHL+ A P+AY Sbjct: 5 IIAEKPSVARDIARIVGASN-KQEGYLASTPSADFQLEGSDYVVTWAMGHLIALAMPEAY 63 Query: 55 DSRYARWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGD 103 ++ + DLPI P +QL R P+ KQL VI+ +A I+ A D Sbjct: 64 G--FSAYKREDLPIRPNPFQLVVRQVRKDKEYHDDPAALKQLKVIRSCFDKADRIIVATD 121 Query: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 REG+L+ + +L + +R I+ L +A+ + L+ S + L SA Sbjct: 122 AGREGELIFRYIYQHLNCC----KPFERLWISSLTDKAIREGLSNLKPGSSYDNLYYSAK 177 Query: 164 ARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 AR+ ADWL GIN +RA +I R GY S+GRVQTP L +V RR +F + +++ Sbjct: 178 ARSEADWLVGINASRALSI-ARKGGY----SLGRVQTPTLAMVCRRYIANRDFSSVPYWK 232 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDK 282 + H + + E Y+ E A+ + + Q V S K Sbjct: 233 LSVHTEKEG------LSLKAIGSEDYESE-------ASAQTALATLRSQSRLTVESVARK 279 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PL + L+ALQ +A +R G SA L I Q LYE K+ TYPR+ RY+ E+ F Sbjct: 280 VTHTAPPLLYDLTALQKDANRRHGFSADKTLSIAQSLYE-KKITTYPRTGSRYISEDVFE 338 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 A++ I + + D+ KV HHAIIPT L+ +EA + Sbjct: 339 EVPALLRKIG---------KTLSNPLNIHSVDNAKVTDHHAIIPTGEMP-TGLSTDEANI 388 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL---------LGSK 453 YN++ ++ F PD+ + + F KA GW+ + K Sbjct: 389 YNMVVTRFAEAFSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQKELVTDAEKKEK 448 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 E D+E LP + +G+ L E+ +T+P +T+ATLLSAM + V++ D + Sbjct: 449 ENDDELVLPSLPDLTEGEVLSLVSAEITAHKTKPKPLYTEATLLSAMENAGKEVKEDDKR 508 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTA 572 K + G+GT ATRA IIE L R ++ + + I T+ G A++ + + +MT Sbjct: 509 KAMAEC-GIGTPATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKDKKIANAEMTG 567 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSA 626 WE L I + + F Q + + + ++ Q V P G + Sbjct: 568 SWELALAAIEAGKMPSERFAQGINSYVGTICEELLSLSSEQKSYPVYRCPKCGQQS 623 >UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepID=A1WZY5_CAMJJ Length = 730 Score = 533 bits (1373), Expect = e-150, Method: Composition-based stats. Identities = 222/661 (33%), Positives = 353/661 (53%), Gaps = 45/661 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L ++ G+G+I+ G+ +VTW GH+LE A+P+ YD +Y Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNYKSGEGYIQKGDN-IVTWAFGHILELAKPEEYDEKYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W L DLP+ ++++ P+ KQL +I +H + + IV+ GD D EGQ+LVDE++ Y Sbjct: 60 WKLEDLPLPIKEFKYLPKKESKKQLKIICDLIHSDKITSIVNCGDADDEGQILVDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + V R LINDL P+AV+ I +++ N++F + AR++ADW+ GIN+TR Sbjct: 120 ----SKTSKPVFRVLINDLTPKAVKEEIAKIKPNADFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI+ R GY+G+LSVGRVQTP+L L+V RD+E ENF + +++ + Sbjct: 176 AYTIMARKNGYEGILSVGRVQTPILALIVNRDKEFENFKSINYYSLLGDFNINN------ 229 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E ++L LA+ + Q A + + + + E PLP++L LQ Sbjct: 230 -----NTIKARLKTEDKILDENLAKEIKESCENQNAKI-NLKIENKKEYPPLPYNLLVLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV--HAP 356 E AK FG S L+I Q L E HK ITY RSDC+YLPE F ++N I ++ Sbjct: 284 AECAKLFGFSPDKTLEITQILREKHKAITYNRSDCQYLPETMFEQAPNILNIIKENLNSN 343 Query: 357 DLLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 D + + D I+++ ++D + AH+ IIPT + LT++E VYNLIA+++++QF Sbjct: 344 DEIQALIASSDLTIKSKAFNDANISAHYGIIPTQNKISSQLTQDELVVYNLIAKRFIIQF 403 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE-----RDEENDGTPLPVVAK 469 ++ I L++ + F A ++G+R+L + + + END L ++ Sbjct: 404 FHPREYQTTTINLEVNQRIFTATQNKTTKSGFRSLWQNIDSEEEQENNENDINDLSILKN 463 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 GD C ++ ++QT+P ++T TLL + +A++V D+ +KK+L D G Sbjct: 464 GDIAKCSLIQIEKKQTKPRPYYTMTTLLKDLNSVAKYVSDERIKKLLIEKDKDKKGESGG 523 Query: 522 LGTEATRAGIIELLFKRGFLT---KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 +GT ATR+ I+ L +R ++ K + I ST G+ L P+ PDMTA W Sbjct: 524 IGTPATRSNHIKTLIEREYIEVSKDKKQIIKSTKKGRDLIKLSPKSLITPDMTALWFEQQ 583 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRT------PVRQFRGIVAPGSGGSADKKKAA 632 I + R + F++ + + I + + I P K+ Sbjct: 584 KMIEISELRREQFLEEITKEVISEIQRIDKNQEFKILDNENKPKIQCPQCNKGFLTKRKG 643 Query: 633 P 633 Sbjct: 644 K 644 >UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8_9BACE Length = 711 Score = 533 bits (1372), Expect = e-149, Method: Composition-based stats. Identities = 196/652 (30%), Positives = 314/652 (48%), Gaps = 52/652 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKPS+AR IA + RK +G+ GNG VTW +GHL++ A PD Y + Sbjct: 1 MITILAEKPSVAREIARI-TGATRKEEGYY-TGNGYHVTWALGHLVQPALPDGYG--FKG 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 + LP++PE++ L PR T KQ+ VI + E+ I+ A D REG+ Sbjct: 57 FRRDSLPVIPEEFMLIPRQVKTDKGYKADAAAVKQIKVITKLWQESEGIIVATDCAREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + Y +R I+ L A+ + + L+ E+ L ++A AR+ AD Sbjct: 117 LIFRYLYAYTGCT----LPFRRLWISSLTDTAIRKGLKELKDGHEYDDLYLAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ A +G SVGRVQTP L +V +R E F + ++ H Sbjct: 173 WLVGINGTQALTV----AAGRGTYSVGRVQTPTLAMVCKRYRENRRFTPEPVHQL--HFS 226 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 P+ T + S ++E L ++ A+ A VT K + E+ P Sbjct: 227 VPSANAGTVVKFASVKKWQDKNEAAILYNKVKAKMC--------ATVTKVEKKEKVENPP 278 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ EA + G +A+ L++ QKLYE KL+TYPR+ R++PE+ FA + Sbjct: 279 LLYDLTTLQKEANTKHGFTAEQTLELVQKLYEA-KLVTYPRTSSRHIPEDVFAEIPLLFE 337 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 ++ H L + V + R D KV HHA++ T L +NE +Y++IA + Sbjct: 338 RLAGH-STLSDKIVNLDGLNRRSVDASKVTDHHALLVTPNRPLA-LYKNEQIIYDMIAGR 395 Query: 410 YLMQFCPDAVFRKCVIELD--------IAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 + F + V + + F AK + +AGWR + G E E+N Sbjct: 396 MVEAFSEECVKDTATVVAEVVPDAGERCEGLTFEAKGCIVRKAGWRGVYG--EYGEDNGN 453 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF-VQDKDLKKILRATD 520 T LP +GD L+ + T+P T+++LL+AM R V+D++ ++ L+ Sbjct: 454 TALPDWTEGDTLVMAGCSMSSGMTRPKPLHTESSLLAAMETAGRDDVEDEEARQALKDC- 512 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLT 579 G+GT ATRA IIE L +R ++ + + + T+ G AL+ + +M +MT WE+ L Sbjct: 513 GIGTPATRAAIIETLIRREYMVRVKKSLVPTEKGLALYSIVKDMDIANVEMTGRWEAELA 572 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQA---KRTPVRQFRGIVAPGSGGSADK 628 +I + + ++ FM+ + ++ R + G P G + Sbjct: 573 EIEKGKTPHEAFMRDIESYTRKITTDLLACDRIFGHKASGCTCPKCGKGTMQ 624 >UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris pv. vesicatoria str. 85-10 RepID=Q3BZV2_XANC5 Length = 728 Score = 531 bits (1367), Expect = e-149, Method: Composition-based stats. Identities = 234/697 (33%), Positives = 363/697 (52%), Gaps = 58/697 (8%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 +L++AEKPS+ +A+A L K P G G+ V W GH+ + A+PD Y R Sbjct: 4 FKLYVAEKPSVGKALAGHLAKSAPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERT 63 Query: 59 -----------ARWNLADLPIVP--EKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPD 105 W LP++P ++W+L P + ++ +++ L A+ +VHAGD D Sbjct: 64 YPEAKRGANGRFPWLFDHLPLLPANDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDID 123 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 REGQLLVDEVL+ L+ R V+R L ++ +V+R + R N +F + +A+AR Sbjct: 124 REGQLLVDEVLEDLRC----RVPVKRVLPKAIDDVSVQRVLADERDNRDFARMRDAAIAR 179 Query: 166 ARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVK 225 RADWL G+N +R T+ R AG G +S+GRVQTPVLGL+ R+ EI NF D+ + Sbjct: 180 GRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLT 239 Query: 226 AHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 A I A +F A W+P +P DE GRLL +A V +++G+ + Y D++++ Sbjct: 240 AMIAVQA-GKFRAKWRPRNG-QPGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKN 297 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 E+APLPFSL LQ A++R+G+ + L + Q LY++ KL+TYPR+DC YLP A Sbjct: 298 ENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAA 356 Query: 346 AVMNAI--SVHAPDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAK 401 ++ A+ DL Q +D ++R +DDK+V AHH I+PT +++ + L+ E Sbjct: 357 EIVQAVREGFRGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSREERL 416 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE------- 454 +Y IAR+YL QF P +RK + ++A F+A R + GW+ L G E Sbjct: 417 IYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADDDA 476 Query: 455 -RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 ++ D LP + + + CE + ++T+PP FTD TLL AM I ++V +K Sbjct: 477 APQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVK 536 Query: 514 ----KILRATD----------GLGTEATRAGIIELLFKRGFLT-----KKGRYIHSTDAG 554 +L+ ++ G+GT ATR L + G + KK ++ T AG Sbjct: 537 AHFVAMLKKSEAGADDQAQGCGIGTPATRHTFAPKLIEIGVVEHIAGKKKAKFFAPTAAG 596 Query: 555 KALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF 614 AL+ +LP T PD TA W+ +I + + FM + ++ + +RQ Sbjct: 597 LALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINAMLAE-----IRQL 651 Query: 615 RGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 R ++ K A ++++A K GSGA Sbjct: 652 RIVLPDLGPRRVPPTKTAGKRKTASKGGKKANGGSGA 688 >UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID=B2RGV8_PORG3 Length = 709 Score = 530 bits (1366), Expect = e-149, Method: Composition-based stats. Identities = 195/655 (29%), Positives = 325/655 (49%), Gaps = 58/655 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA V+ + K +G+IE G G VTW +GHL+ A P+ Y Sbjct: 1 MKVIIAEKPSVAREIARVV-RATNKKNGYIEGG-GYAVTWALGHLITAAMPEVYG--IKG 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 ++ +LPI+P + L PR PS QL VI++ A I+ A D REG+ Sbjct: 57 FHKENLPILPPVFTLIPRQVRSGKGYKADPSAVAQLKVIEKLFKAAEGIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL +A + +R I+ L +A++ + RL++ + + L +A AR+ AD Sbjct: 117 LVFRFIYEYLGIA----KPFERLWISSLTDKAIKEGLARLQNGAAYDNLYYAARARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A +I A +G S+GRVQTP L +V R E + F + F+++ + Sbjct: 173 WLVGINATQAISI----AAGRGTYSLGRVQTPTLCMVCSRFLEHKKFEPQPFWQLSLAVK 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 DE F R + A + +++ P A V + K + Sbjct: 229 -EGDESFR------------FSSADRWFDKTEATALYDKLKQAPYATVETIVRKEARQEP 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA RFG SA+ L + Q+LYE ITYPR+ RY+PE+ FA A++ Sbjct: 276 PLLYDLTTLQKEANSRFGYSAEQTLSLAQRLYE-KAYITYPRTGSRYVPEDVFAEIPAMI 334 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 + H P ++ D KKV HHA++ T + I++ +EA +Y++IA Sbjct: 335 AFLHDH-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP-IDVFGDEAVIYDMIAG 392 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--------- 459 + L F V + + KF+ K + E GWR++L + + ++ Sbjct: 393 RMLEAFSARCVKDISTVTAVCEEVKFILKGEIIKEEGWRSILKNSRKKDKEQAEAEERES 452 Query: 460 ----DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 +G +P +G +L + + T+P T+++LL+AM + ++D++L+ Sbjct: 453 RENGEGIIIPQWEEGGQLPLCACSLAQGTTKPKPLHTESSLLAAMETAGKELEDEELRAQ 512 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHW 574 + G+GT ATRA IIE LF R ++ ++ + + T+ G A++ + EM +MT W Sbjct: 513 FKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVREMKIGNAEMTGQW 571 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV---RQFRGIVAPGSGGSA 626 E+ L +I + + +DF + + Q+ D+ + + ++ I P G Sbjct: 572 EADLAKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSDIHCPKCGKGT 626 >UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID=TOP3_STAEQ Length = 711 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 188/660 (28%), Positives = 311/660 (47%), Gaps = 49/660 (7%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+ R IA+ L +K +G+IE G +VTW +GHL+ A P+ Y+ Y Sbjct: 1 MKSLILAEKPSVGRDIANAL-NLQQKSNGYIE-GKQYIVTWALGHLVTNATPEQYNPSYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 WNL DLPI+P+K + +Q ++K + EI+ A D REG+L+ +LD Sbjct: 59 EWNLEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILD 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ ++R I+ + +A++ +L++ + + L +ALAR+ ADW+ GIN T Sbjct: 119 KVG----NKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS+GRVQTP + +V R +EI F + ++ + ++ Sbjct: 175 RALTT-----KYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINV--------- 220 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + ++ R + E + ++I Q + K + A F+L+ L Sbjct: 221 ------DGYDLNLKQQKRYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLTDL 274 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-----S 352 Q EA K + + + L+ Q LYE HKL+TYPR+D YL ++ + AI Sbjct: 275 QQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATDYK 334 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 H DL+ + + ++++KV HHAIIPT +I L++ E K+Y LIA ++L Sbjct: 335 SHVRDLISESFSS---KMHIFNNQKVSDHHAIIPTEVRPSIEQLSQREFKIYMLIAERFL 391 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 ++ I + FV K + G++ L +D+ + T +G Sbjct: 392 ENLMNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKAL-----KDQTSSHTLTHSFKEGQ 446 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRA 529 + E+ E +T+ P +F + +LL AM + DK K L+ + G+GT ATRA Sbjct: 447 LFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRA 506 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 IIE LF L + I T GK + P T P +TA WE L I + + Q Sbjct: 507 DIIEKLFNMNALESRDGKIKVTSKGKQILELSPSELTSPILTAQWEEKLMLIEKGKYNSQ 566 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 F+Q + ++++++ K + + P G K K + + P Sbjct: 567 KFIQEMKNFTFKVVNKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCK 626 >UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotuberculosis IP 31758 RepID=A7FCC2_YERP3 Length = 815 Score = 528 bits (1360), Expect = e-148, Method: Composition-based stats. Identities = 188/656 (28%), Positives = 313/656 (47%), Gaps = 48/656 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A IA L +K D F E + +++ IGHL+E + + Sbjct: 6 LIIAEKPSVAFDIAKALGGFQKK-DNFFES-DRIIISNGIGHLVEVYSTEMDAEGTK--D 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L+ LP++P +Q++P+P Q N++K+ ++ +++A D REG+L+ + + + Sbjct: 62 LSALPVIPSHFQVKPKPKTISQFNLLKKLMNRPDVGSVINACDAGREGELIFRLIYEAIG 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ ++R I + P A+ A + ++ + + +A R D++ GIN +RA Sbjct: 122 ----SRKPMKRMWIKSMTPTAIREAYENIKDGRFYDRVDDAARCRTEGDFIVGINASRAI 177 Query: 181 TIL-GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T R +L+ GRVQTPVL ++ +R++EI +FV + F+EV A + E + Sbjct: 178 TAFKSRQERSFQMLAAGRVQTPVLSMITQREDEIRSFVQRTFWEVMATFTLASGE-YNGR 236 Query: 240 WQPSEACEPYQDEEG-RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W P+++ Q+ +G R + A+ ++++ G + K P F+ +ALQ Sbjct: 237 WIPAKSTNSNQESDGSRFFDQSAAKAILDKCRGVEPTSVTEVSKITKSHPPKLFNQTALQ 296 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI------S 352 IEA KR+ SA+ LD+ Q LYE HK+++YPR+ LPE++ ++M + Sbjct: 297 IEANKRYKFSAKKTLDLTQALYEKHKMVSYPRTSSTALPEDYGDTVLSIMTHLFTGSEYE 356 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQY 410 +A + +DP + +D+ ++ H AIIP ++ + LT +E K+Y+LI R++ Sbjct: 357 KYAAYVTTHNRIDPSNKT-IFDNDEISDHFAIIPAIGSQCNVAGLTPDELKIYDLIVRRF 415 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + F P A + +A+ F R L E GW+ ++ + N L + +G Sbjct: 416 IAAFYPVATYSATERLTIVAEESFKTTGRVLLETGWQAVIKQPTDNATNS---LCALKEG 472 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + + + T PP F ATLL+AM + V D DL K ++ GLGT+ATRAG Sbjct: 473 ETAGNKVMGLKTGNTTPPSRFNVATLLAAMQTAGKLVDDDDLAKAMKGC-GLGTDATRAG 531 Query: 531 IIELLFKRG---------FLTKKGRY--IHSTDAGKALFHSLPE----MATRPDMTAHWE 575 IIE L ++ +G+ T L L + M T P MT WE Sbjct: 532 IIEGLLSNKTAAGNAKEPYIVIEGKEQLFVPTPKAMDLISFLRDNNVLMLTNPTMTGEWE 591 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK-------RTPVRQFRGIVAPGSGG 624 L+ + + Q FM + Q+ID K P R F G P Sbjct: 592 QKLSLMEHGKYNRQTFMAEIAENTRQMIDTIKVRASEIPAEPHRDFAGAKCPKCPS 647 >UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium hafniense RepID=B8G1K2_DESHD Length = 777 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 190/673 (28%), Positives = 336/673 (49%), Gaps = 34/673 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY---DSRYA 59 L IAEKPS AR A L ++ +G+ E + +++WCIGHL E P+ Y Sbjct: 5 LIIAEKPSQAREYAKTLGVKGKR-EGYFE-NDEYIISWCIGHLFELKAPENYMDLPKVGK 62 Query: 60 RWNLADLPIVPE--KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 RW++ LP++P ++Q + KQ V++ L E +++ D DREGQLL EV Sbjct: 63 RWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEV 122 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 D + ++ + R I+ L +A+ + +LR E L + R+ DW +G+N Sbjct: 123 WDAVG----SKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMN 178 Query: 176 MTRAYTILGRN----AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 +T +T L + V+S+GRVQTP L LVV ++ IENFV + EV+A + Sbjct: 179 LTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASG 238 Query: 232 ADERFTAIWQPSEACEPYQDEEGR----LLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 + P+ +++E +L + +V ++ G+P + S DK E Sbjct: 239 QGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEP 298 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL F L++L + A+KR+G A+ VL I Q LYE K ITYPR+DC YLP + Sbjct: 299 HPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYE-KKAITYPRTDCNYLPPDMLPKLKVH 357 Query: 348 MNAISVHA-PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLI 406 + A+ + + + +P + ++ + AHHAIIPT NL+ +E K++ +I Sbjct: 358 LQALEQSPFASWVKEALDNPLPGGKRVINE-ITAHHAIIPTTEKMIPNLSPDERKIWEMI 416 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 ++L + P A + + + + + F+ K + L E+GW+ + +++ E G LP+ Sbjct: 417 VLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENTEKYT-EGSGLQLPL 475 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + + +E++ + ++++T+PP+ +T L+ AM G + ++D+ L++ L+ GLGT A Sbjct: 476 LQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKG-KGLGTVA 534 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE------MATRPDMTAHWESVLTQ 580 TR IIE L RG+L ++ + + T G L + E + +MT E L Q Sbjct: 535 TRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQMEYELAQ 594 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSADKKKAAPRKRSA 638 + + +M+ + + +I++ + + + + AP G++ +K + + Sbjct: 595 VERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAPQKAGASGRKSKSNLEEKP 654 Query: 639 KKSPPADEVGSGA 651 ++ P +V A Sbjct: 655 QELPVQAKVTKAA 667 >UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2MEK2_9PORP Length = 699 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 179/643 (27%), Positives = 303/643 (47%), Gaps = 47/643 (7%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 I EKPS+A IA VL H K +G++ + +TW GHL+ A P Y + + Sbjct: 7 IITEKPSVAMDIAKVLNVTH-KSEGYLY-NDQYKITWAYGHLVALADPQTYG--FTSYAR 62 Query: 64 ADLPIVPEKWQLQPRPSVTK-------------QLNVIKRFLHEASEIVHAGDPDREGQL 110 +LP++P+ ++L R K QLNVIK+ + I+ A D REG+L Sbjct: 63 EELPMLPKPFKLVVRQVKKKDGKGYEEDDFARKQLNVIKQCFDSSERIIVATDAGREGEL 122 Query: 111 LVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADW 170 + + YL + + R ++ + QA+ A +L+ + L ++ AR+ ADW Sbjct: 123 IFRYIYYYLGCS----KPFDRLWLSSMTDQAIRDAFTKLKEGQLYDNLYLAGKARSEADW 178 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 L G+N +RA TI +G LS+GRVQTP L ++ R +NFV F+++ A + + Sbjct: 179 LVGMNASRALTIASNGSG---GLSLGRVQTPTLCMICDRYLSNKNFVKSPFWKINAQVKS 235 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAP 289 + +P + ++ LA+ + +S VT K S P Sbjct: 236 GETTFTVSSPEP-------------ITNKGLADSKLYAVSNLTSLTVTKAERKSTSSQPP 282 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ EA K+ G +A+ L+I Q LYE K+ TYPR+ RY+P++ + ++ Sbjct: 283 LLYDLTTLQKEANKQ-GFTAEQTLNIAQSLYE-KKVTTYPRTGSRYIPKDVYDTMSYLLR 340 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 + + Q ++ + DD K+ HHAII T ++ +LTE+EA +Y +IA + Sbjct: 341 QLPYQEYQIYAQGLIVAGLNPHSVDDSKITDHHAIITTGETA--DLTEDEAIIYKMIAMR 398 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG---TPLPV 466 L P + + L + V + + GWR + G D ++D LP Sbjct: 399 MLEAVSPASNKELLSLTLSGGGEELVTTLSCIKKKGWRVVKGETTEDPDSDEVSLNSLPS 458 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +A G EL + + E +T+P +T+ATLL AM + ++DK+ ++ ++ GLGT A Sbjct: 459 IADGMELSLVQATLKEGETKPKPIYTEATLLGAMERAGKEIEDKEAREAMQDV-GLGTPA 517 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQ 585 TRA IIE L ++ + ++ + T+ G +++ + + ++T WE L +I Sbjct: 518 TRASIIEKLLRQNYAVRQKNQLIPTERGLVVYNLVKSRLIGNAELTGQWEKSLAEIEAGN 577 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADK 628 F + Q+ D+ T V + P + + Sbjct: 578 LPPTTFNSQIEDYTKQITDELLSTSVSLGTNYICPLCHQESVR 620 >UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_9DELT Length = 1409 Score = 527 bits (1358), Expect = e-148, Method: Composition-based stats. Identities = 205/679 (30%), Positives = 339/679 (49%), Gaps = 51/679 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + +AEKPS+AR IA L R+ G++E G G VTW +GHL+ A+P D+ + W+ Sbjct: 4 VVVAEKPSVARDIAAALGATQRR-KGYLE-GEGYRVTWAVGHLVGLAEPGDIDAAWKYWD 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 LA LP++P W L+ QL V+ R + E+V A D REG+L+ + + + Sbjct: 62 LATLPMLPRSWPLRALEHGADQLAVLARLMNARGVKELVSATDAGREGELIFRYIYEQVG 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +R I+ L +A+ RLRS ++ L +A AR+RADWL G+N++RAY Sbjct: 122 CT----KPWRRLWISALTHEAIRAGFRRLRSPAQLEGLANAARARSRADWLVGMNLSRAY 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++ + LSVGRVQTP L ++V R+ I FV + + EV A E Sbjct: 178 SLR-----HDDSLSVGRVQTPTLAMLVERERAIREFVPELYREVHARFGASVGEYEGVYH 232 Query: 241 QPS---------EACEPYQDEEG------RLLHRP-LAEHVVNRISGQPAIVTSYNDKRE 284 +P+ A +P +D + RL P AE V+ R A V S + + Sbjct: 233 RPAPPDSETQAQRAAKPRRDAKAAANTLARLPAEPDEAEEVIARAKRGEAHVASVSRTKR 292 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 S PL + L+ LQ A + FG SA+ LDI Q LYE HK ++YPR+D R++ E Sbjct: 293 SFPPPLLYDLTELQRHANRLFGFSAKRTLDIAQTLYERHKALSYPRTDSRHIDRETAGTL 352 Query: 345 HAVMNAISVHAP----DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA 400 +++ AI+ +L+ + + + +R +D KV HHAI+PTA ++ +EA Sbjct: 353 GSIVAAIAPSYSGAETNLVAERSGERPLGSRYVNDAKVSDHHAILPTAERPSLRAGSDEA 412 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAK-----------GKFVAKARFLAEAGWRTL 449 K+Y+L+ R+ L + + + +E I ++++ + + GW+ + Sbjct: 413 KIYDLVCRRLLAAYHEPHIEARTKVETHIVTARPEAGVEAIVDRYLSTGSSVEQEGWK-V 471 Query: 450 LGSKERDEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 L + R + LP +AK + + +QTQPPR ++ATLL AM R + Sbjct: 472 LDLRVRPKAKTEPKLPGGLAKDQAVRVLDVRALSKQTQPPRPHSEATLLGAMEHAGRQLD 531 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKG-RYIHSTDAGKALFHSLPEMATR 567 D+ L + +R + GLGT ATRA IELL +RG++ ++G + + ++ G+ L ++ Sbjct: 532 DEQLGEAMRGS-GLGTPATRAATIELLLRRGYVEREGSKALRASPKGERLIDAVHPQVKS 590 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSAD 627 P+MT +WE L Q+ + + FMQ + + ++ + R +P G + Sbjct: 591 PEMTGNWELSLHQMRGEAGELEAFMQTIERYVSEVCAAVQAQGRAPPR---SPRPGPARA 647 Query: 628 KKKAAPRKRSAKKSPPADE 646 + + + R+ + PA + Sbjct: 648 QHEPSDRRAHPGQPGPARQ 666 >UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3R3E4_9BACE Length = 698 Score = 527 bits (1357), Expect = e-148, Method: Composition-based stats. Identities = 195/669 (29%), Positives = 310/669 (46%), Gaps = 51/669 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ +K DG+I GNG +VTW +GHL+ A P Y Y R Sbjct: 1 MIAIIAEKPSVGQEIARVVGATEKK-DGYI-TGNGYMVTWALGHLVSLALPGTYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRP-----------SVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++PE ++L R + +QL VI E I+ A D REG+ Sbjct: 57 TTAEDLPMLPEPFRLVERQIRTDRGMVTDIAAGRQLKVIDGVFSECDSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L + +R + L +A+ + + LR E+ L +A +RA+AD Sbjct: 117 LIFRWIYSHLGCT----KPFKRLWFSSLTDEAIRKGMADLREGYEYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N +RA + +A S+GRVQTP L ++ R +E NFV+ ++++ + Sbjct: 173 WLVGMNASRALAAVSGSANN----SIGRVQTPTLAMICARFKENRNFVSTPYWQLHITL- 227 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESA 288 + EA + E + AE RI G +T + A Sbjct: 228 -----------KQGEAHRLFIHPE-HFGDKKAAETAYGRIIPGSAVTITKVERGTVFQQA 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L++LQ + L+A L I Q LYE KL++YPR+ RY+PE+ A A++ Sbjct: 276 PLLYDLTSLQKDCNIHHDLTADKTLSIAQSLYE-KKLVSYPRTGSRYIPEDIMANIPALL 334 Query: 349 NA-ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 I++ + + R D KV HHA+I T + L+E E+ VY LIA Sbjct: 335 EKIIAMPLFREYGRTFDFSALNTRSVDTTKVTDHHALIITGVAPE-ELSEAESAVYTLIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK---ERDEENDGTPL 464 + L F P + ++E F +++ F+ GWR + K E+DE DG Sbjct: 394 GRMLEAFSPPCEKERLLMECMCGGMDFRSRSAFIVNTGWRAVFARKEDREKDEPEDGGGT 453 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 + A+G + + +++T P +T+ATLL+AM + + D + ++ ++ + G+GT Sbjct: 454 ALFAEGGLVPLSGRGLSQKKTLPRPLYTEATLLAAMENCGKDITDGEARETVKDS-GIGT 512 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISE 583 ATRA II LFKR ++ + G+ I T+ G L+ S+ + M ++T WE L +I Sbjct: 513 PATRAAIITTLFKRNYVERSGKSILPTEKGLYLYESVKDMMVADAELTGTWERALARIEG 572 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 + FM + ++ + R P S K A K Sbjct: 573 RTLDPDSFMLSIREYTGKVTGEILRLK------FPEPSSHAFTCPKCKAGNVVVKSKVAK 626 Query: 644 ADEVGSGAI 652 D G G + Sbjct: 627 CDREGCGLL 635 >UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYW8_9BACL Length = 702 Score = 525 bits (1352), Expect = e-147, Method: Composition-based stats. Identities = 182/655 (27%), Positives = 311/655 (47%), Gaps = 45/655 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ + + EKPS+AR IA L + K +G +E G+ VVTW +GHL+ PD Y + Sbjct: 1 MKSVVLCEKPSVARDIARNLGAKNNK-NGCLE-GDKYVVTWALGHLITLQTPDKYK-EFN 57 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 +L +LP++P+ + + KQ V++ L+ E++ A D REG+L+ ++D Sbjct: 58 NVSLENLPMIPKFMKTEIIKKTFKQYKVVENALNRKDVNEVIIATDAGREGELVARYIID 117 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + + V+R I+ + +A++ L+ E++ L S +ARA ADWL GIN + Sbjct: 118 KAKC----NKNVKRLWISSVTDKAIKDGFRNLKDGKEYLGLYHSGIARANADWLVGINAS 173 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y L+ GRVQTP L +V R+E+I+ F KD++ +A I Sbjct: 174 RALTL-----KYNASLNCGRVQTPTLQMVFEREEKIKQFKPKDYYTFEAQIDGVKFSCGN 228 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + AE + + + K ++ S ++L+ + Sbjct: 229 SE-----------------FNLEKAEQFIKKNINKEIKFNDVQKKAKTSSVKPLYNLTDI 271 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q A+ FG+S + L+I Q LYE HK++TYPR+D RYL + + AI + Sbjct: 272 QQTASALFGMSPKQTLNIVQSLYERHKVLTYPRTDSRYLTSDMKNTLKDRIQAIGGDFKE 331 Query: 358 LLPQPVVDPDIR-NRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFC 415 + + + D + ++ KV HHAIIPT + +++++ E K+YNL+A+++L Sbjct: 332 TIAKLLKVKDYNTKKIINNAKVSDHHAIIPTEQKPNYMSMSDMETKIYNLVAKRFLENLL 391 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P+ + + +I F AK + + G++ L + +D+ + + + Sbjct: 392 PEYKYEETTYSFNIENKVFSAKGLKVIQEGYKELSREELQDKTINL-------QNNNHKL 444 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E ++QT PP ++T+ TL+ AM FV D++ +KIL+ T+G+GT ATRA I+E L Sbjct: 445 ESLVYNKKQTTPPSYYTEGTLIYAMENPFEFVDDENERKILKETNGIGTVATRADILEKL 504 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 F +L I +T+ K L + +P+ P +TA WE L I++ + F+ + Sbjct: 505 FTNDYLVLDNGRIKTTNKAKQLLNLVPKNLKSPSLTAVWEKQLDNIAKNKLSKDKFLNDV 564 Query: 596 VGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 I + K + R G G + K SP Sbjct: 565 KDYTKSCIAEIKDSEDRFKHDNISGKKCEECGSFMLEVDKKGTKMLKCSSPSCRN 619 >UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=A8U720_9LACT Length = 713 Score = 523 bits (1348), Expect = e-147, Method: Composition-based stats. Identities = 188/609 (30%), Positives = 322/609 (52%), Gaps = 24/609 (3%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 R+ +AEKPS A+A A+ K +K I + ++TW GHL+E A P+ Y + +W Sbjct: 3 RVILAEKPSQAQAYAESFGKFSKKDGYIILNPSNDIITWGFGHLVELASPEEYRDEWKKW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 N+ +LPI+P+ ++ + +KQ N+IKR L EA +IV A D DREG+ + ++ + Sbjct: 63 NMKELPIIPQTFKFKVGQGKSKQFNIIKRLLKEADQIVIATDSDREGENIARSIISQAKA 122 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 ++++R IN L +++ LR +F + A R +DWL GIN++R YT Sbjct: 123 D---NKEIKRLWINSLEADEIQKGFSDLRDGKDFYSAYIEAQTRQISDWLVGINLSRMYT 179 Query: 182 ILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + + G GV SVGRVQTP L ++ R +EIENF+ + FFE+ A I F A + Sbjct: 180 LSLQKKGINEGVFSVGRVQTPTLYMIYTRQKEIENFIPEPFFEMHATIKAEK-GSFKAKY 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P + E L+ + ++ P +++ KR S+ +P FSLS LQ Sbjct: 239 NKKF---PTKKELQDLIKKH------ELLASNPGVISDIGTKRISQPSPFLFSLSDLQSL 289 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 K++ +S + L Q LYE KL++YPRSDCR++ + F ++ + Sbjct: 290 INKKYKVSPSDTLKHVQSLYEA-KLLSYPRSDCRHITDSEFHYLIERIDGYQSVLNYTIE 348 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQYLMQFCP 416 QP + R R D KV H+AIIPT + LT + ++Y + ++ + F Sbjct: 349 QP--NTSKRKRYVDGSKVQEHYAIIPTKKVPTQKELDKLTSIQKEIYYTVLKRTMAMFET 406 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVVAKGDELLC 475 D + + I ++I K F++K R + + GWR L + ++ ++ + T LP+V K + + Sbjct: 407 DYKYDETTITVEIKKLPFISKGRTILDKGWRKLEYAASKKTDKEENTELPLVQKNEAIEA 466 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E T PP+ +T+ TL++AM + +++ + K+IL+AT+G+GTEATRA ++E L Sbjct: 467 -DLATSEGFTAPPKSYTEGTLITAMKTCGKELENVEEKEILKATEGIGTEATRANVLETL 525 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 K+ ++ + + T G L ++ + + P+MTA WE+ L +I +++ + F++ Sbjct: 526 KKQHYIEIQKNDVTVTQKGAILCQAVKNTLLSSPEMTAKWETYLKKIKKEEGTQEAFLEN 585 Query: 595 LVGTLYQLI 603 + + + Sbjct: 586 IQKFIDHTL 594 >UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=C7XFN2_9PORP Length = 698 Score = 520 bits (1340), Expect = e-146, Method: Composition-based stats. Identities = 190/669 (28%), Positives = 305/669 (45%), Gaps = 51/669 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ +K DG+I GNG +VTW +GHL+ A PDAY Y R Sbjct: 1 MIAIIAEKPSVGQDIARVVGATEKK-DGYI-VGNGYMVTWALGHLVSLALPDAYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++P+ ++L R T +QL VI L I+ A D REG+ Sbjct: 57 TAAEDLPMIPDPFRLVVRQVRTDRGMVTDIAAGRQLKVIGEVLAGCESIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL + +R I+ L +A+ + L+ + + L +A +RA+AD Sbjct: 117 LIFRWIYSYLGCT----KPFKRLWISSLTDEAIREGMASLKEGTGYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N +RA + S+GRVQTP L ++ R +E NFV+ ++++ + Sbjct: 173 WLVGMNASRALAAASGSVNN----SIGRVQTPTLAMICARFKENRNFVSTPYWQLHIVLK 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI-VTSYNDKRESESA 288 R + +E + + +AE I+ + + +T + + A Sbjct: 229 RDNGHR-----------QFIHTKEFK--DKNMAEAAYKSITPRSVVTITKVKRGKIFQQA 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ALQ + + L L I Q LYE KL++YPR+ RY+P++ A ++ Sbjct: 276 PLLYDLTALQKDCNIHYDLPVDKTLAITQSLYE-KKLVSYPRTGSRYIPQDVMAHIPVLL 334 Query: 349 NAISVHAP-DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 I+ + + + R D KV HHA+I T L+E E+ VY LIA Sbjct: 335 EKITAMPEFREYRRSLDLSALNTRSVDAAKVTDHHALIITGIVPE-GLSEAESTVYTLIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK---ERDEENDGTPL 464 + L F P ++E F +++ +A GWR + K E+DE Sbjct: 394 GRMLEAFSPPCEKELLLMECVCGGLDFHSRSTVIANPGWRAVFSRKEDREKDEPERDEGT 453 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 +G+E+ + +++T P +T+ATLL+AM + + D ++ ++ T G+GT Sbjct: 454 ASFTEGEEIPVMGHGLSQKKTLPKPLYTEATLLTAMENCGKEITDGQAREAVKDT-GIGT 512 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISE 583 ATRA II L KR ++ + G+ I T+ G L+ S+ + M +T WE L QI Sbjct: 513 PATRAAIITTLLKRDYIERSGKSIRPTEKGLYLYESVKDMMVADAKLTGTWEKALEQIEG 572 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 + + FM + ++ + R P S A K K Sbjct: 573 RTLDPESFMLSIREYTGKVTGEILRLK------FPEPSSCVLACPKCKTGNVVVKSKVAK 626 Query: 644 ADEVGSGAI 652 D G G + Sbjct: 627 CDREGCGLL 635 >UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0_STRPF Length = 577 Score = 517 bits (1332), Expect = e-145, Method: Composition-based stats. Identities = 189/613 (30%), Positives = 309/613 (50%), Gaps = 47/613 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A IA ++ RK +G+ E GNG +V+WC+GHL++ A PD D ++ + Sbjct: 5 MKLVIAEKPSVAVTIAKIIGARTRK-NGYYE-GNGYIVSWCVGHLIQMASPDKIDEKWKK 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W + +LPI+PE++ + S KQ V+K+ L + +++A D REG+L+ V + Sbjct: 63 WTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNINIVINACDAGREGELIFRLVYNQ 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++++QR I+ + +A+E L+ +F L SA ARA ADWL G+N++R Sbjct: 123 AKC----KKKIQRLWISSMENEAIEDGFRNLKDGEKFEDLYRSASARAIADWLVGMNLSR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 Y+ + Y+ SVGRVQTP L L+ +RD EI F + ++ V Sbjct: 179 LYSCI-----YKETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYG--------- 224 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + D R+ +AE ++N + + ++T DK S P+ L+ LQ Sbjct: 225 ------GLKLVSDRIDRI---EVAEQLLNLLEDE-IVITEVEDKEVSTKPDKPYDLTTLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA K FG SA + L++ Q LYE KLITYPR+D RYL ++ ++ + Sbjct: 275 REANKYFGYSANDTLNLAQALYE-KKLITYPRTDSRYLTDDMVNTMKELLEGLEEDFK-- 331 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQYLMQFCP 416 ++ ++ KV H+AIIPT A +L++ E+KVYNLI + L Sbjct: 332 -----LNKSNFKSIFNSSKVTDHYAIIPTISGIGKAKDLSDKESKVYNLIKDKLLASCSD 386 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 + I + K F A + + + G+ L + +E LP V GD++ Sbjct: 387 NLKESSRKIRYEYDKFNFNASGKTIIDEGYTKYLKAY--GKEKQENELPDVKTGDKIKLT 444 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 + E+ T+ P H+ + TLL AM DKD++ GLGT ATRAGIIE L Sbjct: 445 SKNISEKFTKAPSHYNEDTLLKAMENAGVESLDKDIEV---ERKGLGTPATRAGIIENLI 501 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + + + + + T+ G L + + + T+ WE L +I+ + +DF++ + Sbjct: 502 HKELIRRDKKNLLVTEKGNRLVSIVEDKFKSAETTSEWEMKLAKINSGEVDKEDFLREIE 561 Query: 597 GTLYQLIDQAKRT 609 ++ +L+D+ K Sbjct: 562 DSIRELVDRYKNN 574 >UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiaceae RepID=B2UQJ6_AKKM8 Length = 869 Score = 516 bits (1330), Expect = e-145, Method: Composition-based stats. Identities = 189/627 (30%), Positives = 304/627 (48%), Gaps = 34/627 (5%) Query: 3 LFIAEKPSLARAIADVLPK----PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 L IAEKPS+A +A VL K R G + ++T +GHLLEQ +P + + Sbjct: 5 LIIAEKPSVATDLARVLGKELGKFTRDKSGAFYQNDRAIITSAVGHLLEQKKPMTEEGKS 64 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVL 116 W LP++P K++L+P +L + + EIV+A D REG+L+ + Sbjct: 65 LPWKFDYLPVIPRKFELEPIKQSEDRLKKVLQLARSKDVTEIVNACDAGREGELIFHNLA 124 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y + + +R + + +A+ A +RS ++ PL +A+ R+ +DWL G+N Sbjct: 125 RYGKWT----KPTRRLWMQSMTDEAILNAWHGMRSEADMKPLTNAAVCRSESDWLVGLNS 180 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA TIL G+ V GRVQTP L ++ +R+ EI+ F + + EV A + + Sbjct: 181 TRALTILQSRGGFN-VTPAGRVQTPTLAILTQRELEIQAFEPEPYSEVWAEFDVQS-GSY 238 Query: 237 TAIW--QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + W + + + R+ A + +R G+ VT K + APL + L Sbjct: 239 SGRWIDRDWKKNDHPHSRAERIWDPEQAAVIRDRCRGKAGTVTE-EKKPVTTVAPLLYDL 297 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++LQ EAA R+G SA+ L + Q+ YE HK++TYPR+D RYLPE++ + ++ ++ Sbjct: 298 TSLQREAANRYGFSAKRTLQLAQECYEKHKVLTYPRTDSRYLPEDYLGKVYGIVGTVAEQ 357 Query: 355 APDLLP-----QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 P+ P R +D KKV H AIIPT + LT + K++ ++ + Sbjct: 358 NPEFAPFARDILDNKRIKPNRRVFDTKKVSDHFAIIPTGKM--EKLTGDAQKLFEMVMAR 415 Query: 410 YLMQFCPDAVFRKC-----VIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +L F P AVF + D F+ R L E GW+ + G K + L Sbjct: 416 FLAVFFPAAVFEDTRRTTLITHQDGVTDAFLTTGRVLVEPGWQAVYGRKAGTSSKEE--L 473 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 V G++ + E+ T+PP + +ATLL+AM G + V D++L + GLGT Sbjct: 474 VPVRDGEQAALREIEIRNAMTKPPARYNEATLLAAMEGAGKLVHDEELAAAMSE-RGLGT 532 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQ 580 ATRA IIE L + ++ + GR + +T G L L + T P +T WE L Q Sbjct: 533 PATRASIIEGLISQEYIVRDGRELLATRRGIELIALLERIGLKTLTSPSLTGEWEYKLKQ 592 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + + FM+ + +++ + K Sbjct: 593 MEQAALPRDSFMEGIKTLTGEIVKRVK 619 >UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocellum RepID=C7HGZ2_CLOTM Length = 652 Score = 516 bits (1330), Expect = e-145, Method: Composition-based stats. Identities = 201/637 (31%), Positives = 326/637 (51%), Gaps = 36/637 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGD--GFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 +L+I EKPS+A + A+VL K D VVTWC GHL+ A PDAYD +Y Sbjct: 4 KLYITEKPSVAASFAEVLGMKITKQDRSKGYAESEHSVVTWCFGHLITMAYPDAYDPKYR 63 Query: 60 RWNLADLPIVPEKWQLQPRPS--VTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 W + DLPI+P+ ++ + KQ IK ++ + I D REG+ + V Sbjct: 64 EWKVEDLPIIPKVYKYIVIDDEGIKKQFETIKTLMNREDIDLIFACTDSGREGEYIFRLV 123 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + ++ +R I+ +A+ I + E+ L +A +RA+ DWL+G+N Sbjct: 124 YE----QSGSNKKAKRVWISSQTEEAIREGILNAKDIEEYDSLARAAYSRAKEDWLFGMN 179 Query: 176 MTRAYTILGRNAGYQ-------GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 +R YT L V+++GRV T VLGLVV R++EI NF+ K + + A Sbjct: 180 FSRIYTCLYGRKLSNFLKESKTSVIAIGRVMTCVLGLVVDREQEIRNFMPKKHYGITATF 239 Query: 229 VTP-ADERFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 ++ ++ + W P + + D+E + + R AE V+ R+ G P + K + E Sbjct: 240 LSSVSNLLYKGKWVPQNKKDDKEADDEEKYISREEAEQVIERLKGHPGKIKKVEVKTKKE 299 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 PL F+L+ LQ EA K+F L L+I Q LYE KLITYPR+D R + + Sbjct: 300 QPPLLFNLAELQSEANKKFKLPVDKTLEIAQWLYE-KKLITYPRTDSRVISTDVLEEVPK 358 Query: 347 VMNAISVHAP--DLLPQPVVDPDIR-----NRCWDDKKVDAHHAIIPT-ARSSAINLTEN 398 V+N I + D + + D++ R D+ KV H+AIIPT + + + EN Sbjct: 359 VLNGIYKNPEYRDYVLKIKEMGDLKVTKSTKRYVDNSKVTDHYAIIPTYVNAETVRMDEN 418 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG--SKERD 456 VYNLI +++L F P AV+ +E + FV+ A+ L EAGW+ + + ++D Sbjct: 419 TKNVYNLIVKRFLAIFFPPAVYNTVRVETVVNNEIFVSNAKTLKEAGWKEVYEVSAPKQD 478 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 EE P+ ++ K + + + E+ E++T+PP +TD +L+ M +F++D++L++ + Sbjct: 479 EELTEAPIHLLVKNEAVEAKDFELEEKETKPPSRYTDGSLIITMEKAGKFIEDEELREQI 538 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTK--KGRYIHSTDAGKALFHSLP---EMATRPDMT 571 + T G+GT ATRAGII+ L G++ K + + T G+A+ + P +T Sbjct: 539 K-TCGIGTSATRAGIIKKLSDIGYIKINPKTQVVTPTLKGEAIVELVRRTARELLSPSLT 597 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 A WE L I K+ + F + L + + I++ KR Sbjct: 598 ASWEKGLAMIENKETTAEIFEEKLCVYINKTINKVKR 634 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 514 bits (1323), Expect = e-144, Method: Composition-based stats. Identities = 192/636 (30%), Positives = 309/636 (48%), Gaps = 53/636 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A A + +K DG+IE G +TW +GHLLE A Sbjct: 1 MKLIIAEKPSVAIDTAKAISPKFQKKDGYIEAGE-YTITWAVGHLLEIDDTIAP----KE 55 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPI+PEK++ + KQ N++K + +A EI D REG+L+ +L Y Sbjct: 56 WKLETLPILPEKFEYKVSKGKNKQFNIVKSLVKKADEIFVNTDAGREGELIARLILLYSG 115 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + R ++ L + R + + + L S LAR ++DWL GIN+TRA Sbjct: 116 W--NGWDKTYRFWTSEALTKNVILRELKARKPAKNWDSLFYSGLARQQSDWLVGINLTRA 173 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T++ G V S+GRVQTPVL L+V RD EI+NF K +++++A ++F A Sbjct: 174 LTVI---VGDGSVWSIGRVQTPVLKLIVERDLEIKNFKPKPYWQLEAVFE-KDSQKFKAK 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQ 298 +++ + + + + A+V K+ + AP FS++ LQ Sbjct: 230 L--------LNEKDTIFEDKNKIWEIFKALKDKDKAVVKEIEKKQHKKYAPPLFSITTLQ 281 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + A KRFG +AQ L + Q LYE K I+YPR++ ++L +E+ + + V N + + Sbjct: 282 MTANKRFGFTAQKTLMLAQDLYEA-KYISYPRTEAQHL-DENPSTKDLVKNILKKLGEEQ 339 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLMQ 413 L + V + R +D K+ H+AIIP ++ L ++ K+Y LI ++L Sbjct: 340 LIENVDK--VGKRVFDSSKLTDHYAIIPMNLLTEEKAKKEGLNQDHLKIYELIKNRFLAV 397 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F P + LDI +F A + GW+ + +E +++ PLP + KGD + Sbjct: 398 FMPPYEYETTKAILDIDGYQFTASGKVELSLGWKAI--DREDEDDKIEAPLPQLEKGDMV 455 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 V+E +T+PP H+T++TLL+ M + LGT ATRAGII+ Sbjct: 456 HKISQRVIEDKTKPPAHYTESTLLNKMKQL-----------------ELGTGATRAGIIQ 498 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQI---SEKQCRYQ 589 L R ++ KG+ + +T+ G AL + + P MT+ WE L QI + Y+ Sbjct: 499 TLKDRFYIKNKGKSLIATEKGFALIEKIKDKEFASPKMTSKWEQQLEQIYTQKLGKKGYE 558 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGS 625 DF+ + + ++ K ++ + V G Sbjct: 559 DFLNQIKEFTKKEVEAVKGISIQMEQKPVGRCRCGG 594 >UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FFH7_FLAJ1 Length = 689 Score = 514 bits (1323), Expect = e-144, Method: Composition-based stats. Identities = 191/623 (30%), Positives = 302/623 (48%), Gaps = 40/623 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS AR IA VL + K DG++ GNG VTW +GHL+ P+ Y Sbjct: 1 MKVVIAEKPSAAREIA-VLLGANEKKDGYL-AGNGYFVTWALGHLVGLGLPEDYG--IKG 56 Query: 61 WNLADLPIVPEKWQLQPRPSV-----------TKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + + LPI+P+ + L R KQL IK + + I+ A D REG+ Sbjct: 57 FEKSSLPILPDPFLLTVRKQKIDAGYTADAGAQKQLKTIKYVVGLSDLIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL E R+ R I++L +A+ + ++ L+ SE L ++A AR+RAD Sbjct: 117 LIFRYIYEYL----EFRKPFVRLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSRAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN ++A ++ A GV S+GRVQTP L LV R E ++F + +++++ Sbjct: 173 WLVGINASQALSL----AQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQLQLT-H 227 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 + FT+I + + + R + R A A V+S K +E P Sbjct: 228 SRNFMLFTSISEKRWDNKRQAMDALRAIERNAA----------TAWVSSVEIKNSTEQPP 277 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L F L+ LQ +A+ LSA L I Q LYE I+YPR+ R + + + +++ Sbjct: 278 LLFDLTGLQKQASTDLSLSAGETLSIAQSLYEKQ-FISYPRTGSRSISADVWDEIPSLIK 336 Query: 350 AISVHAPDLLPQPVVD-PDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 A+ + + R + V HH ++PT R + L+ E +YNLIA Sbjct: 337 ALGTRENFREAISTLKLGRLNKRIVSEAGVTDHHGLLPTERIPSA-LSGKETAIYNLIAG 395 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + L + + L + F+ + E+GWR + E G LP + Sbjct: 396 RLLEAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWRGVKARFLESGEP-GQELPEIK 454 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GDEL ++ V+E+ T PP +T+A LLS M + QD +KIL+A G+GT ATR Sbjct: 455 RGDELKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQERKILQAI-GIGTPATR 513 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQCR 587 A IIE LF R ++ ++G+ + T+ G ++ + + MTA WE+ L +I K+ Sbjct: 514 AAIIETLFDRKYIQRQGKSLIPTEKGLMVYELVKDKRIADVAMTAQWETELWKIENKEAD 573 Query: 588 YQDFMQPLVGTLYQLIDQAKRTP 610 F + + + + TP Sbjct: 574 AATFQKQMESYATSITKELLETP 596 >UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID=C9Q4L2_9VIBR Length = 736 Score = 512 bits (1319), Expect = e-143, Method: Composition-based stats. Identities = 235/668 (35%), Positives = 353/668 (52%), Gaps = 43/668 (6%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MR+FIAEKPSLA AI L K +G+ + G VVTWC+GHLL P+ Y+ + Sbjct: 1 MRVFIAEKPSLAAAIFKGLGGDVNTEKKNGYYQHGQD-VVTWCLGHLLALCDPEDYNIEH 59 Query: 59 ARWNLADLPI-VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +W L+ LP+ +L+PR KQL V+ ++ +A+ IVHAGDPD EG LL+DEVL Sbjct: 60 KKWALSYLPLETMYPPRLKPRKGAEKQLKVVLEWIGKATSIVHAGDPDPEGCLLIDEVLQ 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + VQR LI DLN + V+ A+ L+ N F+PL ALAR+ AD +G N+T Sbjct: 120 Y----ANNTKPVQRVLIADLNDKPVKAALANLQPNENFLPLTQKALARSIADQTFGYNLT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RAYT+ R G+ VL++GRV T ++G++ R +N ++E+ H + Sbjct: 176 RAYTLKAREKGFDDVLNIGRVITAMIGMINERTLANQNHQKSFYYELFGHFSVAGN-TIK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A P E E DE+GR++ + A++ S K ES +APLPF+LS L Sbjct: 235 AKLIPDEHFEL--DEQGRMISSLEVAATKEADTNASAVIQSVEQKEESRAAPLPFNLSKL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 QIEA+KR+G + VLD Q LYE HKL+TYPRSD ++L + H + AI P Sbjct: 293 QIEASKRWGYKPKEVLDALQALYEKHKLLTYPRSDNQFLSDAHLENAPQIFAAIQGTMPH 352 Query: 358 LLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFC 415 L P ++ ++ K++AHHAI+PT +S + I L E + +Y LIA++++ F Sbjct: 353 LSDAVTQATPTSTHKAFNAAKIEAHHAIVPTEKSGAGIELNERKKNLYELIAKRFVALFY 412 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVVAKGDELL 474 PDA K + ++ + A L GW L + DE N L + +G E Sbjct: 413 PDAKRSKVMADIACTGRIYRATQTTLTTQGWEVLFKGEHNDEPNQNLIDLSTLTEGAEAR 472 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR--------ATDGLGTEA 526 C ++ ER+T+PP++F DA+LL AMT A+F++D L+K L +GTEA Sbjct: 473 CSHLDMEERETKPPKYFDDASLLKAMTQAAKFIKDPVLRKTLEAKDKDTAGENGSIGTEA 532 Query: 527 TRAGIIELL----------FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 TR+G IE + ++G+ K +T+AG+ LP+ RPD++A WE Sbjct: 533 TRSGHIEKVGKLTHLVTLTKEKGY---KNPVYKTTEAGQEFCALLPDEIVRPDISAIWEG 589 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPR 634 L +I++++ + F+ + + +D K P + +G+V P ++ Sbjct: 590 SLNKIAKREESIEAFLHSVNHYIATQVDHVKTQGVPFSKRQGMVCPTC------QQGTLT 643 Query: 635 KRSAKKSP 642 KR + P Sbjct: 644 KRKGQNGP 651 >UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria IOP40-10 RepID=B1F998_9BURK Length = 690 Score = 511 bits (1316), Expect = e-143, Method: Composition-based stats. Identities = 228/639 (35%), Positives = 346/639 (54%), Gaps = 26/639 (4%) Query: 2 RLFIAEKPSLARAIADVL-PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 RL+IAEKPSLA+ + V +P R G + G+ V GH+L QA PD Y Sbjct: 3 RLYIAEKPSLAKDVMAVFDGRPSRNGPAYKVGGDFFV--PLKGHILAQAMPDFYLPDDVP 60 Query: 59 ------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 W +DLP++P W LQP+ L+ I++ L E+VH GDPD EGQLLV Sbjct: 61 LNRNGNKIWRASDLPVIPSTWILQPQEEHASILDAIRQLLANVDEVVHLGDPDAEGQLLV 120 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADW 170 DEVL+YL V+R L+N+ NP + +A+ LR+N E F ALAR+R DW Sbjct: 121 DEVLEYLG----NTLPVKRLLVNNNNPNEIRKALANLRNNDEPEFRAWHRWALARSRYDW 176 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 L+G+N TRA T ++ G+ +LSVG VQTPVL +V RD++IE F +F + A + Sbjct: 177 LFGLNFTRAATCRAQSLGFDALLSVGSVQTPVLQIVFERDDKIERFKPTSYFLLSAQLQH 236 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 FTA W+ ++ + DE+GRL+ +A + ++ PA V+++ K + APL Sbjct: 237 AK-GAFTAKWRAADD-QLGLDEDGRLVDPDVAAALAQSLTNAPATVSAFERKPARDLAPL 294 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 P SL+ L +EA +RFG +A VLD Q+LY+ +KL TYPR++ RYL E + A Sbjct: 295 PLSLNELTVEACRRFGCTAAEVLDAAQELYDRYKLTTYPRTENRYLAEAQHDEAPDALAA 354 Query: 351 ISVHAPDLLPQ-PVVDPDIRNRCWDDKKVD--AHHAIIPT-ARSSAINLTENEAKVYNLI 406 ++ + DL P D +R+R +DD+K+D HH I+PT R+ LT + +VY+LI Sbjct: 355 LAANRADLAPLVDRADLTLRSRAFDDEKMDGDPHHGIVPTARRADLSTLTPLQHQVYDLI 414 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 R YL+QF P A F + IE++ + +A R +GW +L E + ++D LP Sbjct: 415 VRYYLVQFYPAATFMQTSIEVESGGNRLIAGGRTPVSSGWLAVLKPSEPETDDDVQMLPQ 474 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +A GD+LL ++ ++T+PP F +ATL+ AM + ++ D K L+A G+GT A Sbjct: 475 LAVGDQLLVIDVDLQAKETRPPARFDEATLIDAMIDLHKYTDDPAAKARLKAGKGIGTSA 534 Query: 527 TRAGIIELLFKRGF---LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISE 583 TRAGII +RGF + ++ +AL +LPE P + ++ L +++ Sbjct: 535 TRAGIIAEHRERGFLVPVKGSKTRFMTSPTARALLAALPEPVKDPTVAGMFKIALDAVAD 594 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGS 622 + + FMQ + +++ P++ P Sbjct: 595 GEMTFDAFMQRSEKMVTRIVGVIAEAPMQLPGARPCPVC 633 >UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damselae subsp. damselae CIP 102761 RepID=D0Z5F5_LISDA Length = 727 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 207/657 (31%), Positives = 329/657 (50%), Gaps = 37/657 (5%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MRLFIAEKPSLA+AI + L ++ G+ E GN +VTWC+GHLLEQ+ P+ Sbjct: 1 MRLFIAEKPSLAKAIFEGLGGNPKTQRKQGYFENGND-IVTWCVGHLLEQSPPEH----- 54 Query: 59 ARWNLADLPIVPEKW-QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +W L LPI E +++P Q V++ + +A IV+A DPD EG LL DE+L Sbjct: 55 -QWKLEYLPIKSEYPPKMRPIEKTKDQFKVVQDLIKKADSIVNASDPDEEGNLLCDEILT 113 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + V+R L+ DLN + V+RA+ ++ N F SALAR+ D ++G NM+ Sbjct: 114 YCH----NTKPVERLLVADLNLEPVKRALANMQPNENFHGWTQSALARSIGDLIFGFNMS 169 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +AYT+ R GY G +GRVQT LG++ R ++ F++V A ++ Sbjct: 170 QAYTLKAREMGYSGTFGIGRVQTVALGMINERTLANQSHQESYFYQVYADFAF-NNQTVK 228 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + P+ E DE+ RLL + A+ + Q A++ K P P+ LS+L Sbjct: 229 ARYLPTTNNEV--DEQNRLLSKTEAKQIAQATDNQHALIIDAQTKPTKSLPPRPYDLSSL 286 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q AK++G SA+ LDICQ LYE HK++TYPR+D R+L + H R A+ I+ P+ Sbjct: 287 QQLCAKKWGYSAKKTLDICQSLYEKHKVLTYPRTDNRFLGDSHLEQRVAIFKNIAEAIPE 346 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFC 415 L D +++ +D K+ AHHAI+PT + + LT++E +Y +AR ++ F Sbjct: 347 LSSMVANADLSLKHHAFDASKITAHHAIVPTLTSAKGLTLTKDEQTIYEFVARSFIALFY 406 Query: 416 PDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSK-ERDEENDGTPLPVVAKGDEL 473 P +V + + +++A +F A L+ GW L E ++ +G L + + E Sbjct: 407 PASVRDRTEVTIELANKYRFKANQTQLSVVGWEVLYKDDIEAEKPIEGVDLTTLKRDQET 466 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG--------LGTE 525 + + +T+PP++ +A+L++ M + ++D +L+ A D +GTE Sbjct: 467 KASNPTIEKGKTKPPKYHDEASLIAFMKKAGKLIKDPELRAKFEAKDKGDRDNCGSIGTE 526 Query: 526 ATRAGIIELLFKRGFLTK-------KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 ATRA I++ + R L + K + +T G+ LP T PD++A W Sbjct: 527 ATRANILDTVKSRSDLVQVVKMKGYKQKVWITTPLGQEFCAMLPSEFTAPDISAIWSQHQ 586 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-FRGIVAPGSGGSADKKKAAPR 634 I + F+ L G + +D+ K V P K+ + Sbjct: 587 LAIKNGDMTVEQFLDELDGFVAHYVDKVKTNGVNITVETFDCPNCADGHLIKRNGSK 643 >UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y9I3_COPPD Length = 685 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 192/619 (31%), Positives = 307/619 (49%), Gaps = 43/619 (6%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L + EKPS+AR IA L KP ++G+ + V+ +GHLL+ A P+ Y RY +W Sbjct: 3 ILIVTEKPSVARQIAAALGKPKKEGNHLVVG--EYVIAHAMGHLLQFAYPEHYGERYKKW 60 Query: 62 NLADLPIVP--EKWQLQPRPSV-TKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 L DLPI+P ++WQL P KQL IK +A ++ A D REG+L+ + Y Sbjct: 61 RLEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQY 120 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + + ++R + L + + I +L SE L SALARA+ADWL GIN +R Sbjct: 121 VGI----EKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASR 176 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A+T++ + V S+GRVQTP L ++V R++EI++FV + +++VK Sbjct: 177 AFTVVSKK----EVFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEG------ 226 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + E + + AE + + G+ IVT +++ + PL L LQ Sbjct: 227 --------KSFWAESVKEYDQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQ 278 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 ++ F SAQ L I QKLYE + LITYPR+D RYLP + N + Sbjct: 279 KFTSRSFKWSAQKTLKILQKLYE-NALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKG 337 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 + V + R R +++ +V H AIIPT + L ++ K++N + ++L F P A Sbjct: 338 NWEYVKKLNNRGRIFNNARVTDHFAIIPTGKIK--ELKGDDEKMFNYVVDRFLAAFYPPA 395 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + F A + + W T+LG KE E LP +A+ ++ + Sbjct: 396 LETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQE-----LLPKIAE---VMVLET 447 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 +RQT+P FTD L++AM + V+ ++L +IL+ G+GT ATRA IIE L + Sbjct: 448 SAEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKE-KGIGTPATRAEIIERLIEM 506 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEM----ATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 G++ + G + T G L +L E+ T P++T WE L I + + + FM Sbjct: 507 GYVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFMWS 566 Query: 595 LVGTLYQLIDQAKRTPVRQ 613 + + ++ + + Sbjct: 567 IEEYVKDVVQTLSKEESSK 585 >UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group RepID=A9VVE2_BACWK Length = 714 Score = 510 bits (1313), Expect = e-143, Method: Composition-based stats. Identities = 193/655 (29%), Positives = 315/655 (48%), Gaps = 42/655 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFI-----ECGNGQVVTWCIGHLLEQAQPDAYDSR 57 L +AEKP+ A+A A+ PK ++ F +G +TW GHL+E P Y Sbjct: 4 LVLAEKPNQAKAYAEAFPKVEKREGHFYVPPCSLLPSGGNITWAYGHLVELKSPQDYKKE 63 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W+L+ LPI+P +++ + KQ N++K+ + EA V D DREG+ + ++ Sbjct: 64 WEKWDLSQLPILPSRYEYKVSADKKKQFNIVKKLMKEADTTVVDVDIDREGEAIARLIIQ 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++++R IN L +++ L+ +F + A AR +DW+ G+N + Sbjct: 124 EAGCTH---KKIKRLWINSLEVDEIKKGFQNLKPGEDFESMFEEAQARQLSDWIVGMNAS 180 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R YT+L R G QGV SVGR QTP L L+ +R +EI+NF FFE++A +P + Sbjct: 181 RLYTLLLRQKGVQGVYSVGRCQTPALCLINKRQQEIKNFKPTPFFELEAQFTSPNGV-YM 239 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 ++ + L L +H ++ S Q +V S K + + A FSLS++ Sbjct: 240 GRYKERFTTKGE-------LMNLLQQHSISENSSQQGMVKSVEVKPKQQEATKLFSLSSI 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP- 356 Q A K++ S +VL Q+LYE KL+TYPR+DC Y+ E F ++ A Sbjct: 293 QALANKKYKYSPADVLKGIQELYEA-KLVTYPRTDCNYITEGEFEYLKNNLSGYQSIASV 351 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN----LTENEAKVYNLIARQYLM 412 + P + R D+KKV H+AI+ T + L + + +Y + + L Sbjct: 352 NFQPHSL---TANKRYVDNKKVQEHYAIVLTKNVPSRETIARLPDKQRNLYMEVLKSVLS 408 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP---LPVVAK 469 F ++ + VI D+ F K + GW+ L + + +EE+D LPVV + Sbjct: 409 MFYAPYMYEETVITSDLNGLLFTTKGKAEKSLGWKELYVTDKIEEEDDQEKVSLLPVVKQ 468 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + + E T PP+ +T+ L++ M V+D++ K IL+ +GLGTEATRA Sbjct: 469 GEFVQ-GLVKSKEGVTTPPKPYTEGQLITMMKTCGSSVEDEESKIILKEVEGLGTEATRA 527 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRY 588 GIIE L K+G++ K + T G+ L S+ M +P++TA WE L +I ++Q Sbjct: 528 GIIETLKKQGYIEVKRNKVSVTPKGEILCESVQGTMLAKPELTAKWEGYLRKIGKEQGSK 587 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVR------------QFRGIVAPGSGGSADKKKA 631 F+ + LI +A + + P G +K Sbjct: 588 DIFVSQTSEFIKDLIKEATESIGELKIDNKIQDMKAKDTIGKCPKCGKDVVNRKT 642 >UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shewanella putrefaciens 200 RepID=A2UW18_SHEPU Length = 708 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 214/682 (31%), Positives = 328/682 (48%), Gaps = 37/682 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG-----QVVTWCIGHLLEQAQPDAYD 55 M L IAEKP++A+AIA L K R +G+I+CG Q+V+WCIGHLL P+ ++ Sbjct: 1 MHLIIAEKPAVAKAIAGYLNKNARSCNGYIDCGADGKGQKQIVSWCIGHLLTFKTPEEHN 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 Y W + LP+ L+P QL + L A+ + HAGD D EGQ+LVDEV Sbjct: 61 PLYKTWAVETLPMQLLPLTLKPIAKTKAQLKTLLDLLKSANLVTHAGDDDDEGQILVDEV 120 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 LDY + + QV R INDLN ++ +A ++ NS+F+ SA R+ D++YG+N Sbjct: 121 LDYAK----YKGQVNRLKINDLNEASIAKAFSNVKPNSQFLSQSQSAYGRSAFDFIYGLN 176 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-PADE 234 +TR T+L +G GV SVGRVQ+ +L LVV R + + ++++ A + Sbjct: 177 LTRLCTVL---SGNGGVFSVGRVQSAILSLVVERCRLNRSHTSIPYYDIFAAVRFREGAI 233 Query: 235 RFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +F CEP + D++ RLL RP AE + + G+ +T + S PLPFS Sbjct: 234 KFKVDLNEIAECEPEKFDDKKRLLDRPQAEFIKLSLEGRSVNITDLDRTNSEASPPLPFS 293 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L LQ + F S + L + Q L E HKLITY R+D YLPEE + N I + Sbjct: 294 LLDLQKACSNLFDYSPEQTLKLTQSLREDHKLITYNRTDTGYLPEEFHPQGAHIANCIKL 353 Query: 354 HAPDLLPQPVVDP-DIRNRCWDDKKV--DAHHAIIPTA-RSSAINLTENEAKVYNLIARQ 409 + I++R + D KV AHH IIP R+ +T++E VY LI R Sbjct: 354 NCSAFAAAVDAADFSIKSRAFSDAKVAESAHHGIIPCDVRADMGKVTKDEMNVYMLICRN 413 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL-PVVA 468 +L QF P + + + K A + GW L + +++ + L + Sbjct: 414 FLAQFFPKKITAHIKVTASAGEYKLTAMGSQIERNGWSALYSGESFEDDEEQAELTQELT 473 Query: 469 KGDELL-----------CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL- 516 DEL + E +++P + + LL + A +V +++LK++L Sbjct: 474 AFDELDGLGKYDSGHIYSGDTSLREGKSKPKALYVMSRLLEDLKKAATYVTNENLKRVLI 533 Query: 517 ------RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDM 570 + G+GT ATR IIELLF R F+ KG+ I +T G+ + LP D+ Sbjct: 534 ERDKGTQEKGGIGTPATRGSIIELLFNRQFIEMKGKKIIATPFGEQAYDQLPSYLASVDL 593 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKK 630 TA W+ + Q+ +++ F+ + G + Q ++ K + + + G A K Sbjct: 594 TAFWQLKMNQVRDRELSIGRFLTEVDGFVTQAVNHIKSQGISITSQPTSKTNKGKAGAKS 653 Query: 631 AAPRKRSAKKSPPADEVGSGAI 652 P+ S + G I Sbjct: 654 GKPKMASTATEFQCKQCGEKLI 675 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 215/618 (34%), Positives = 312/618 (50%), Gaps = 64/618 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I EKPS+A IA L KP R+ G++E G +VTW GHLLE + R Sbjct: 1 MKLVITEKPSVALDIARALGKPTRR-QGYLEVGE-YLVTWTYGHLLEIGE-----IAPKR 53 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNL DLPI PEK++ Q V+++ L A +++ GD REG+L+V E+L++ Sbjct: 54 WNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDAGREGELIVRELLEFTG 113 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R +V R ++ L V R + RLR +SEF L SALAR DW+ GIN+TR Sbjct: 114 ----YRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNGDWIVGINLTRL 169 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ AG V SVGRVQTP L ++V+RD EIE F + ++ V A Sbjct: 170 VTL---KAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFEGEM------- 219 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQ 298 + EE RL R AE VVN + + V + +R E PL SL++LQ Sbjct: 220 ----KGVMLRNGEEARL-AREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTSLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA +GLSA+ LD+ Q LYE KLI+YPR+D RYL E + V+ + +L Sbjct: 275 REANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGR--GEL 332 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 +P+ + R +D K+ HHAIIP R NL KVY+L+ R+++ F D Sbjct: 333 VPR---VDRVGKRVFDSSKLTDHHAIIPLDRPPE-NLPAIHRKVYDLVYRKFVGAFMDDY 388 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V+ + + + F+ + + + GW L E++ +P E+ E Sbjct: 389 VYELQRVFIRLDGELFLVEGKRNLQLGWMELYPH-----EDNPLKIPS----GEVRKEWV 439 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 + ERQT+PP FT+A+LL M + LGT ATRAGIIE L +R Sbjct: 440 KAEERQTKPPARFTEASLLREMERLG-----------------LGTPATRAGIIETLLER 482 Query: 539 GFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQI---SEKQCRYQDFMQP 594 G++ ++G+ ++STD G+ L L PDMTA WE L +I + YQ+FM+ Sbjct: 483 GYVERRGKSLYSTDKGRELVDKLGDSKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEG 542 Query: 595 LVGTLYQLIDQAKRTPVR 612 + + +++ + + Sbjct: 543 IRRFTREEVERLMKREFK 560 >UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacterales RepID=B9KGJ1_CAMLR Length = 676 Score = 505 bits (1300), Expect = e-141, Method: Composition-based stats. Identities = 205/665 (30%), Positives = 348/665 (52%), Gaps = 48/665 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L +K +G+I+ G+ ++TW GH+L A P+ Y+ ++ Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNVKKFEGYIQKGDN-LITWAFGHILRLATPEFYNEKWKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 WNL DLP+ ++++ P + KQL +I + + + IVH GD D EGQ+L+DE++ Y Sbjct: 60 WNLNDLPLDIKEFKYIPINNSKKQLEIICKLIKNDQVDSIVHCGDADDEGQILIDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ V R LINDL P+AV+ I +++ NS+F + AR++ADW+ GIN+TR Sbjct: 120 ----SKTKKPVFRVLINDLTPKAVKAEISKMKPNSQFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AYT + + +G++ VL++GRVQTP+LGL+ RD E ENF + D++ + F Sbjct: 176 AYTSVAQQKSGFREVLTLGRVQTPILGLITARDNEYENFKSMDYYSLLGKFEINGKV-FN 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + E +++ +A+ + I+ ++ S +++ E PLP+SL L Sbjct: 235 ARLKTEE----------KIIDENIAKQI-KEININKTVLISVFKEKKKEYPPLPYSLLIL 283 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q E AK +G S L+I Q L E +K ITY RSDC+YLPE F ++N+I ++ + Sbjct: 284 QAECAKLYGYSPDKTLEITQNLREKYKAITYNRSDCQYLPETMFEQAPNILNSIKLNIKN 343 Query: 358 -----LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 L D I+++ ++DK + AH+ IIPT + L E E +Y LI ++++ Sbjct: 344 NDSDLSLLLEKSDLSIKSKAFNDKNISAHYGIIPTQNNFDCGLLKEEEKNIYILIVKRFV 403 Query: 412 MQFCPDAVFRKCVIELDI-AKGKFVAKARFLAEAGWRTLL---GSKERDEENDGTPLPVV 467 +QF + +E+ K F G+R K+ ++ N+ + ++ Sbjct: 404 IQFFKPREYEVTNLEIQTYDKSVFGTSQSKNISEGFRKFFKQSDEKDNEDTNNHLDISLI 463 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD------- 520 + E+ ++QT+P ++T +LL + +A++V+D+ +KK+L D Sbjct: 464 ENNSACKIKDIEIEKKQTKPRPYYTMDSLLKDLNSVAKYVKDEKIKKLLIEKDKDKKGEN 523 Query: 521 -GLGTEATRAGIIELLFKRGFLT---KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 G+GT ATR+ I+ L ++G++ K + + ST G+ L PE PDMTA W Sbjct: 524 GGIGTPATRSTHIKNLIEQGYIEVSKDKKQVVKSTKKGRLLISLAPETLKYPDMTALWFE 583 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT-------PVRQFRGIVAPGSGGSADKK 629 I + + +DF+Q ++ + I + K + + + P + Sbjct: 584 QQKMIEQGTIKKEDFLQNILKEVNSEILKIKENGSMNQFSQLSKEKQYSCPECKNGYLIR 643 Query: 630 KAAPR 634 + + Sbjct: 644 RKNTK 648 >UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q181Z2_CLOD6 Length = 742 Score = 504 bits (1297), Expect = e-141, Method: Composition-based stats. Identities = 176/625 (28%), Positives = 305/625 (48%), Gaps = 39/625 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L +AEKPS+A+ IA L R+ DG+ E GN ++T+ +GHL+ YD Sbjct: 1 MKLVLAEKPSVAKTIASFLGAKTRQ-DGYFE-GNDYIITYAVGHLVSLYDMKDYDKDKYS 58 Query: 59 ARWNLADLPIVPEK-WQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEV 115 W + + P VPE ++ + S TKQ N +K+ L+ +++A D DREG+L+ + Sbjct: 59 GSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLI 118 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L + ++ V+R L+N+ P+ + R I L+ E L + R DWL GIN Sbjct: 119 F----LLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGIN 174 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 T T+ G +L++GRV P + LV RD EI NFV K ++E++ H A E Sbjct: 175 FTSVATL---KYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEY 231 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 + + +E + A ++ I+ + + E AP FSL+ Sbjct: 232 ---------KGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLT 282 Query: 296 ALQ-IEAAKRFGLSAQNVLDICQKLYE---THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 +LQ +K ++ VL++CQ LYE ITYPR+D +L E + ++ + Sbjct: 283 SLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKL 342 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 V L + + R +D KVD+H AIIPT +L+++E VY+ I +++ Sbjct: 343 KV---GLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPK-SLSKDEQLVYDAIKDRFV 398 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A + I+ ++ F+ K + L G+ + +E+++ LP+V K D Sbjct: 399 ANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKND-----LLPLVNKDD 453 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + + + +QT PP+ +T+ TLL AM + V ++D + + +GT ATRA + Sbjct: 454 VVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDT--TVLSGYSIGTSATRADV 511 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQD 590 ++ + + G++ KKG+ T+ GK L P + D T E L+ I + + ++ Sbjct: 512 LKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKE 571 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFR 615 ++ ++ +YQ ++ K+ + Sbjct: 572 YLTNIISFIYQNVNIIKQDASKNIN 596 >UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepID=Q8CS09_STAES Length = 718 Score = 502 bits (1294), Expect = e-140, Method: Composition-based stats. Identities = 185/656 (28%), Positives = 309/656 (47%), Gaps = 51/656 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIE-----CGNGQVVTWCIGHLLEQAQPDAYDS 56 L IAEKP+ + + L DG+IE +VTWC+GHL++ A + YDS Sbjct: 3 ILIIAEKPNQVKKYVEALGNSFNNKDGYIELESELFDKKVIVTWCVGHLIQLAHMEDYDS 62 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRF---LHEASEIVHAGDPDREGQLLVD 113 +W+ LP +PE + + +KQ +IK L+ SEI+ A DPDREG+ + Sbjct: 63 NLKQWSKDTLPFIPEDFIFKVSDYGSKQFKIIKELCENLNSDSEIIIATDPDREGEAIAR 122 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 VL+ ++ K +++R N P+ ++ A L+ + + A AR+ ADWL G Sbjct: 123 YVLN--KIPCTKNLKLKRLWANTQEPEGLKLAFKNLKDADDTYRFYLEAEARSIADWLVG 180 Query: 174 INMTRAYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 +N TR T+ + G GV SVGRVQTP L +V +R+ EI+NF +K ++E+ A Sbjct: 181 MNFTRYVTLEMKQLGIDEGVFSVGRVQTPTLYMVYKRNNEIKNFESKTYYEMVAKDKENE 240 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + F SE DE + L+ ++ G+ + + + + AP F Sbjct: 241 NAVFK-----SEHKFDSIDEFEQFLNEN---NLNCECEGE---IKEISISEKRKVAPNLF 289 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 L +Q A +++G + L I Q LY+ ++YPR+DC + F ++ Sbjct: 290 KLGGIQKVANQKWGYTLDKTLSIVQSLYD-KGYLSYPRTDCSLITHSEFEYLKDNFSSYC 348 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIAR 408 + Q ++P R + +D KV H+AIIPT + N +++E K+Y+ + + Sbjct: 349 KLLNIEIEQKNIEP--RTQYVNDSKVLEHYAIIPTKQIPENDVYNNFSDDEKKIYDEVVK 406 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + ++ F D ++ + I L I +F E GW+ L + +E LP Sbjct: 407 RTMLMFMEDYIYSETKIVLCIENVEFKLTGNVAKEQGWKLLDSENKNSKEK---LLPNYK 463 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLS---AMTGIARFVQDKDLKKILRATDGLGTE 525 + ++L E T+PP++ T+ATL M ++F+++++LK L+ G+GT Sbjct: 464 ENEKLSL-NLVPKELNTKPPKYLTEATLGGEGGLMENCSKFIENEELKGNLKEVHGIGTP 522 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEK 584 ATR+ I++ L RG+L K +++ T G L +L +MTA+WES L ISEK Sbjct: 523 ATRSSIVKSLIDRGYLETKKKHLMITPKGTLLCSALENTNLVSVEMTANWESTLKDISEK 582 Query: 585 --QCRYQDFMQPLVGTLYQLI------------DQAKRTPVRQFRGIVAPGSGGSA 626 + R +F+ + + Q+I D+ + Q P Sbjct: 583 GHRIRQNEFIDSIKQYIKQMINSDNKLLKLESNDKNIEKAIEQSTICNCPKCSNGR 638 >UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GFF6_9FIRM Length = 1317 Score = 502 bits (1292), Expect = e-140, Method: Composition-based stats. Identities = 188/678 (27%), Positives = 320/678 (47%), Gaps = 43/678 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A +L R DG+IE + V+TWC+GHL+E P+ YD +Y RW Sbjct: 5 LIITEKPSVAQEFARILGVSGR-NDGYIE-NDKYVITWCVGHLVEMVYPEEYDEKYKRWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +PE+++ P V+KQ + + R L + AGD +EGQ + + + + Sbjct: 63 LEDLPFLPEEYKYNVIPDVSKQYDTVHRMLFREDIETVYWAGDAGKEGQTIEENIRRFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + P ++ R I+ + + R I + +E+ L S + R D+ GIN +RA Sbjct: 123 VRPGMKE--LRVWIDSQTEEEILRGIREAKPMAEYDNLAKSGIMRTIEDYAMGINFSRAM 180 Query: 181 TILGRNAGYQG-------VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA- 232 ++ ++VGRV T VLG+VV R+ EI NF F+ V + Sbjct: 181 SVKYGKLLNDAAATKSYTAIAVGRVMTCVLGMVVIREREIRNFAETPFYRVVGGFLPEGA 240 Query: 233 --DERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 +E TA W+ + ++ +E R AE+++ + G+ A+V S + Sbjct: 241 ETEETVTAEWKAVNGSKYFESPLLYKENGFKKRESAENLIGELDGKQAVVKSLERGTSRK 300 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 APL F+L+ LQ E +KR+ +S L + Q LYE KL TYPR+D R L Sbjct: 301 KAPLLFNLAELQAECSKRYKISPDETLQVAQDLYE-KKLTTYPRTDARVLSTAVAKEIGK 359 Query: 347 VMNAISVHAP------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENE 399 +N + + P +L + R + DD K+ H+AIIPT + + + L++ + Sbjct: 360 NLNRLKTYEPTKTYTERILKEGTYRNIARTQYTDDSKITDHYAIIPTGQLTELGSLSDLQ 419 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL---GSKERD 456 +VY+L+ R++L F P A + + + + + A A+ L G+ ++ G+ E Sbjct: 420 RRVYDLVVRRFLSIFYPAAEYETIKLVVQVGAEQLFASAKVLKNPGFLEIMGRPGNDENK 479 Query: 457 EENDGTPLP---VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 EE L + GD L + E+ E +T PP+ +T +++ AM + +++++L+ Sbjct: 480 EEESAGLLKLAGQLKTGDPLKVDGYEIKEGKTAPPKRYTSGSMVLAMENAGQLIEEEELR 539 Query: 514 KILRATDGLGTEATRAGIIELLFKRGF--LTKKGRYIHSTDAGKALFHSLP---EMATRP 568 + ++ + G+GT ATRA II L + G+ L +K + + G+ +F + P Sbjct: 540 EQIKGS-GIGTSATRAEIIRKLVRIGYLNLNQKTQVLSPEAIGEMVFEVVSMTVPALLNP 598 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTL-YQLIDQAKRTPVRQFRGIVAPGSGGSAD 627 MTA WE L I+ +D+ L + + + + + P G Sbjct: 599 KMTASWEKGLDGITRGTVIMEDYRSKLEDFIRKETVSMIEHDLTGNLAARIHPFVGKGG- 657 Query: 628 KKKAAPRKRSAKKSPPAD 645 + A +K+ P Sbjct: 658 -RGLAAKKKIEAVCPVCG 674 >UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID=C9BSW4_ENTFC Length = 801 Score = 499 bits (1286), Expect = e-139, Method: Composition-based stats. Identities = 172/659 (26%), Positives = 313/659 (47%), Gaps = 29/659 (4%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAY 54 M+ + +AEKPS A+A A+ + ++ +G+ E + +T+ GHL++ P AY Sbjct: 60 MKTVILAEKPSQAKAYAETF-QQQKRHEGYYEISDPLFAGEVTITYGFGHLVDMVAPGAY 118 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + R+A+W+L +LPI PE ++ + Q +++KR L A I+ A D DREG+ + Sbjct: 119 EERWAKWSLENLPIFPETFRYEVPMDKRAQFSIVKRELQSADTIIIATDGDREGEAIAWS 178 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 ++ A K + R IN L +A+ L+ + P A AR ADWL G+ Sbjct: 179 IIRQAN-AFSKEKNYLRLWINSLEKEAIYEGFKNLQPGKNYFPKYKEAQARQNADWLIGM 237 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N + Y++L + G G S+GRVQTP L ++ + EEI++F + +FE + ++T Sbjct: 238 NGSPLYSLLLQRKGIDGSFSLGRVQTPTLYMIYQLQEEIKHFKKETYFEGEG-LITTNKG 296 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 +F+ P +A + ++ + E + + Q + K + +P FSL Sbjct: 297 QFSGKIVPKKAFKTQEELTKEI------EKLGAHLGKQNGRILEVTKKEKRLHSPRLFSL 350 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S+LQ + + SA+ LD Q LYE+ K ++YPR+D Y+ E + Sbjct: 351 SSLQTKMNQLMKASAKATLDAAQGLYES-KFLSYPRTDSFYITENEHQYLVKHLQNYKKF 409 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQY 410 + + + R D KKV HHAIIPT L++ + +Y + R Sbjct: 410 LG-IEEVQTTEIKAKKRYVDAKKVQEHHAIIPTKTIPTPARFAKLSKLQQAIYLQVLRTT 468 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + F D ++ + + + + K + + + GW+ +L K + +E LP + + Sbjct: 469 VAMFAADYIYEETTVMTGVQQLKLKSIGKIPLQQGWQEILRIKSKKKE--AQTLPPIVEN 526 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 +E E + +E++TQPP+ +T+ TL++AM + + + + ++IL+ +G+GTEATRA Sbjct: 527 EEAEVE-LKSMEKETQPPKPYTEGTLITAMKTAGKTLDNDEAQEILKEVEGIGTEATRAN 585 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQCRY 588 IIE L ++ ++ I T G L ++ + T +MTA WE L +I +++ Sbjct: 586 IIENLKQKHYIEVNKNEITVTPKGITLCKAVANEPLLTSAEMTARWEGYLRKIGKQEGTP 645 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 F++ + + L+ + + + G+ K + + P + Sbjct: 646 SVFLENIKKFILHLLAEVPNQIDKV---DFSDEISGTRQIKAMEKKNDQLGRCPKCKKG 701 >UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria RepID=B1VJ64_PROMH Length = 772 Score = 499 bits (1286), Expect = e-139, Method: Composition-based stats. Identities = 232/656 (35%), Positives = 354/656 (53%), Gaps = 32/656 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKP--HRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MR+FIAEKPSLA+AI + L K G+ + G+ VVTWC+GH+LE + P YD +Y Sbjct: 1 MRVFIAEKPSLAKAIFEGLGGNPNTEKKKGYFQHGDD-VVTWCVGHMLELSDPQDYDEKY 59 Query: 59 ARWNLADLPIVPE-KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A W DLPI + + Q +I + +A IV+AGDPD EG LLV+E+LD Sbjct: 60 ASWRFGDLPIKTVFPPTYKIKKETAAQTKIILSLIDQAKTIVNAGDPDEEGCLLVNEILD 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + ++ V+R L++DLN V++A+ L+ N +F + SAL+R+ D +G N+T Sbjct: 120 YAK----NKKPVERILVSDLNLAPVKKALADLQPNEKFRGMSNSALSRSLLDQSFGYNLT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R T+ GR GYQGVL+VGRVQ+ VLGLV R +N ++++ A I + Sbjct: 176 RGCTLKGREKGYQGVLNVGRVQSAVLGLVNMRTLANQNHNESFYYDIYALIEMNGHQ-VK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A +Q ++ + D++ RL+ A+H+ +SGQ VT K E+ PLP +LS L Sbjct: 235 AKYQTTDNDQI--DDKRRLISEAQAKHITEIVSGQAVKVTIAATKAENTKPPLPLNLSTL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q AKRFG + Q LDI Q LYETHKL+TYPR+D RYL +EH+ + + A+ P+ Sbjct: 293 QQICAKRFGYAPQETLDIMQSLYETHKLLTYPRTDNRYLSDEHYYQANDIAQAVIGTLPE 352 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFC 415 L +D +++ ++ K++AHHAI+PT + S I L E E VY L++ ++ F Sbjct: 353 LASTVEHMDKVQKHKAFNASKIEAHHAIVPTTKDGSNIQLNEKEKNVYRLVSLYFIGLFY 412 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND----GTPLPVVAKGD 471 PD++ K + DI F A L ++GW +L + +E + L + D Sbjct: 413 PDSIRDKTKVHFDIKGNTFTATQSVLVQSGWESLGKDSDEEETEEPEKLDFDLSTLKFND 472 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG-------LGT 524 +CE V ++ T PP++FT +TLL+AMT A+F+ D +L+KIL A D +GT Sbjct: 473 NGVCETANVDKKPTLPPKYFTASTLLAAMTRAAKFIDDPELRKILEAKDEGSTDQGSIGT 532 Query: 525 EATRAGIIELLFKR-GFLTKKGRY------IHSTDAGKALFHSLPEMATRPDMTAHWESV 577 EATRAGI++ L + G ++ + +T G+ +LP+ T+PD++A W Sbjct: 533 EATRAGILKKLSENTGLISIEKEKGYSELVWKTTKQGQEFCAALPDEITKPDISARWAEK 592 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF-RGIVAPGSGGSADKKKAA 632 I + + DF++ + +LI + + G P K+ Sbjct: 593 QALIKKGELTVADFIKETDSYIKELIAELDANGINITANGTPCPVCQKGFLIKRKG 648 >UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TFR0_HELMI Length = 781 Score = 498 bits (1283), Expect = e-139, Method: Composition-based stats. Identities = 190/683 (27%), Positives = 324/683 (47%), Gaps = 74/683 (10%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKPS A AIA+ + ++K G++E + +TW +GHL++ A+P+ Y S Sbjct: 1 MKTLIIAEKPSAAEAIAEAVAGTYQKKRGYLESPDFY-ITWAVGHLVQLAEPEDYRSSLK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 RW DLPI+P+ +QL+P QL I ++ +++A D REG+L+ ++ YL Sbjct: 60 RWRFGDLPIIPD-FQLRPVKKTEGQLKTIAGLAKKSRALINACDAAREGELIFRYIVAYL 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 +L + R L +A+ A+ L+ + L SA R+ DWL GIN TRA Sbjct: 119 RL---EEMPAWRLWTASLTAEAIRAAMADLKPLDRYDNLFKSARCRSEGDWLIGINATRA 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T + +L++GRVQTPVL ++ + FV + ++EV A + + + Sbjct: 176 FTTR-----FGELLTLGRVQTPVLAMICENRRRRDAFVPETYWEVWARFRGEGCD-YRGL 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + E RL + AE + + G+ V ++K E P + L+ LQ Sbjct: 230 WLREKG------EAHRLNEKGKAEAIAAAVDGRNGEVRQVDEKESRELPPRLYDLTTLQR 283 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV---HAP 356 E + FG SA L I Q+LY++ K ITYPR++ R++ + A V++ ++ + P Sbjct: 284 ECNRLFGFSANKTLKIAQELYDS-KFITYPRTNSRFVDKHGLALLRRVVSGLASHPVYGP 342 Query: 357 DLLPQPVVDPDIRNR-CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 + RNR + V+ HHA++PT L ++ KVY+ I R+ L + Sbjct: 343 FVAQGNPQLVHERNRNICRPEAVEDHHALLPTTLVP-TGLVGDKWKVYDRIVRRVLAHYY 401 Query: 416 PDAVFRKCVIE-----------------------------------LDIAKGKFVAKARF 440 A +R+ V+ D+ F + + Sbjct: 402 LPARYRERVVLTVVPFERITGKATDLPVGDLGMATAVLDSAHSKEADDLGGAVFRSAEKT 461 Query: 441 LAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM 500 + + GW+ + G +E + P G + C EV+E+QT+PP+ +T+ +LL+AM Sbjct: 462 IIDPGWKVVDGGWTPPKEQERFP---ERAGLAVRCAGAEVLEKQTEPPKAYTEGSLLAAM 518 Query: 501 TGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS 560 + + D++L++I++ GLGT ATRA IE L + G++ +GR I T G AL Sbjct: 519 ETAGKQLDDEELREIMKDA-GLGTPATRAATIERLKEVGYIELQGRQIEPTPKGMALISL 577 Query: 561 LPE----MATRPDMTAHWESVLTQISEKQCRYQDF---MQPLVGTLYQLIDQAKRTPVRQ 613 + + + +MT WE L +I+ + +F + L L + ++ A+++ + Sbjct: 578 VEKSEIPLLLSAEMTGRWEKFLNEIARGNAQPLEFNRRVSDLAVYLVKQLEAAEKSWYDK 637 Query: 614 F----RGIVAPGSGGSADKKKAA 632 R P GG+ + + A Sbjct: 638 SACARRLGTCPRCGGAIVENRKA 660 >UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WNM4_EGGLE Length = 741 Score = 497 bits (1279), Expect = e-139, Method: Composition-based stats. Identities = 188/663 (28%), Positives = 299/663 (45%), Gaps = 61/663 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IAD + H + DG+IE G G +++WC GH+++ P Y W+ Sbjct: 4 LIIAEKPSVARGIADAVG-AHERRDGYIEGG-GYLISWCRGHIIDLDFPQNYPQWSGHWS 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASE--IVHAGDPDREGQLLVDEVLDYLQ 120 ++ LP++PE+W+ + +Q V+K L A +V+A D DREG+ + V + Sbjct: 62 MSQLPMIPERWRWSV--TAPEQYKVLKGLLDRADVELVVNACDADREGEGIFRRVWTHSG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ V+R L P+ V + + S++ L +A RA+ADWL G+N +RA Sbjct: 120 C----KKPVRRFWSTSLVPEQVRTDLAHAKPLSDYDGLADAAEGRAKADWLVGLNASRAL 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L LS GRVQTP L LVV R I F + FF+V+ + A R Sbjct: 176 SCLY----EGSRLSAGRVQTPTLALVVERTRAIRGFKSVPFFQVECSVGRTAHVRLAGE- 230 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 +L R A + G + ++E AP + L+ LQ + Sbjct: 231 --------------KLKTRQEALRRAHAAVGSQCAILKVERRQEKCRAPKLYDLTGLQRD 276 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI---SVHAPD 357 A+ R GL+A+ L+ Q LYE KL TYPR++ RY+ E V++AI + Sbjct: 277 ASTRAGLTAEETLNALQTLYE-KKLATYPRTESRYIGESDIPETARVLSAIAVPGIVGEA 335 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQF 414 R DD KV H AI+PTA A L E V LI + + Sbjct: 336 AAAGFDASRSDVARVADDSKVHGHGAILPTALLDAKEMAKLDGAERSVAILICCRLMAAT 395 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----------SKERDEENDGTPL 464 A K +E ++ + A + +A W + DE+++ + Sbjct: 396 MDPATKLKTKVEGEVNGDAYTASGSTVTDASWIAVDEACRAALAGGGKAAEDEDDEAQDI 455 Query: 465 P-VVAKGDELLCEK--GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA--- 518 P + +GD V + +T PP+ +TDATLLSAM R ++D++LK + Sbjct: 456 PADIEQGDSFTVADGDVRVKDGKTTPPKPYTDATLLSAMEHAGRSIEDRELKAAIEDDSM 515 Query: 519 -TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 + GLGT ATRA +IE L + ++ ++G+ + +T+ G+ L + + P++TA WE Sbjct: 516 HSGGLGTPATRARMIEKLIEAKYIRRRGKTLSATERGETLIDIVCDSLKTPELTAKWELA 575 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------APGSGGSADKK 629 L+ + + DF+ + G ++ +R V P G Sbjct: 576 LSHVERGEGSLSDFLSGIEGYTAAVVSDLERGFDPAQAAAVSGREELCRCPACGAPIVLS 635 Query: 630 KAA 632 ++ Sbjct: 636 RSG 638 >UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A6TMD4_ALKMQ Length = 775 Score = 492 bits (1267), Expect = e-137, Method: Composition-based stats. Identities = 180/691 (26%), Positives = 330/691 (47%), Gaps = 52/691 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+IAEKPS+A A L K DGFIE N VVTWCIGHL+ + PD YD +Y +W Sbjct: 5 LYIAEKPSVALEFAKTLNIKGNKKDGFIES-NEAVVTWCIGHLVTMSYPDKYDDKYKKWV 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +P K++ + +V KQ ++IK + I D REG+ + V + + Sbjct: 64 LKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVN 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + + +R I+ + +++ + + E+ L +A RA+ D+L GIN +R Sbjct: 124 VKGKTK---KRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLL 180 Query: 181 TI-----LGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 T+ L + G + V++VGRV T VLG+VV+R+ EI FV ++++ ++ Sbjct: 181 TLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSM 240 Query: 235 RFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQ----PAIVTSYNDKRESE 286 + W+ E+ Y ++ AE + + A+V + K+E++ Sbjct: 241 DYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETK 300 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 + PL ++L+ LQ E +K+ ++ L + QKLYE K+ITYPR+D R L H+ Sbjct: 301 NPPLLYNLAELQNELSKKLKINPDETLKVAQKLYE-KKMITYPRTDARVLSNAVAKEIHS 359 Query: 347 VMN----------------AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR- 389 + I+ ++ + + + + +DK + H+AIIPT Sbjct: 360 NLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEG 419 Query: 390 -SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRT 448 S LT+ E + + LI R++L F P A+F + I I F ++ + G+ Sbjct: 420 LGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLE 479 Query: 449 LLGSKERD---EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 +L ++D + L + KG + K E+ E +T PP+ ++ +++ AM + Sbjct: 480 ILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGK 539 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLPE 563 ++D++L++ ++ + G+GT ATR+GI+ L + ++ + + T G++++ + E Sbjct: 540 LIEDEELREKIKGS-GIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDE 598 Query: 564 MA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR----QFRG 616 +P++TA WE L I+ + + ++M L + + + + + R Sbjct: 599 SIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRS 658 Query: 617 IVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 I + + G+ D K + + K + Sbjct: 659 IKSTTNKGNQDTKGKRVGRLALGKCIACETG 689 >UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus RepID=D2J7B8_STAAU Length = 705 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 171/621 (27%), Positives = 300/621 (48%), Gaps = 35/621 (5%) Query: 1 MRLFI-AEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAY 54 M+ I AEKPS AR A+ L H+K DG+IE N G ++TW GHL+E P Y Sbjct: 1 MKTVIFAEKPSQARDYANALGISHKK-DGYIEGVNPLFDGGVIITWGFGHLVELKLPKDY 59 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + W+L +LP P ++ + +KQ N++K +A +++A D DREG + Sbjct: 60 SNPINNWDLKNLPYRPSPFEYKVSEGKSKQFNIVKTLFKDADILINATDIDREGSNIFY- 118 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L+L K + ++R IN L + +++ +L++N + A AR +D+L G+ Sbjct: 119 --STLKLTGVKNKTIKRLWINSLVEKEIKKGFQQLQNNHQDYQNYQEAYARQTSDYLIGM 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP-AD 233 N++ Y+ + + G Q V S+GRVQTP L ++ R IENF + F+E+ + Sbjct: 177 NLSPVYSKIFQLQGVQDVFSIGRVQTPTLYMIYERYLAIENFKPETFYEIFGEFESKNGC 236 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 + A + ++ E E N + I+T + + S+P S Sbjct: 237 YKGKAKIKTTDKQEIINLGEKH-----------NLKDAKEGIITKLETQEKRTSSPKLHS 285 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL-PEEHFAGRHAVMNAIS 352 LS LQ + K++ S + +I Q LYE K+++YPR+DC Y+ EE+ + + + ++ Sbjct: 286 LSTLQSKINKQYKYSPEKTKNIVQSLYE-KKILSYPRTDCNYITSEEYLYLKENLQSLMN 344 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIAR 408 V+ +V R R +++KV H+AIIPT++ L+++E V + + Sbjct: 345 VYNKHF---SIVYDKPRARYVNNEKVKEHYAIIPTSQIPTPQNIEKLSQDEKYVLDEVVS 401 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 L F D V+ + IE ++ + F + GW+ L K +E++ LP + Sbjct: 402 TTLSMFANDYVYDETKIETNVNQLIFYTTGHTEIQKGWKILFKHK-GNEKSPEQQLPKLI 460 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 K + + + TQ P+ +T+ L++ M +++ D++ +IL+ G+GTEATR Sbjct: 461 KNECVKA-NIYSNKGITQSPKLYTEGQLITLMKSCGKYLDDEE-AEILKEIQGIGTEATR 518 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCR 587 GII+ L + ++ + +H T G L ++ + MTA WE L I + Q Sbjct: 519 DGIIQSLKNKNYIKIEKNKVHITAKGILLCKAVKGSLLASATMTAAWEKRLKLIGQGQAN 578 Query: 588 YQDFMQPLVGTLYQLIDQAKR 608 +F+ + + + I + Sbjct: 579 TDNFIDITMKFIDKEIKAYQE 599 >UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis Bt407 RepID=C3CTB0_BACTU Length = 787 Score = 491 bits (1263), Expect = e-137, Method: Composition-based stats. Identities = 190/645 (29%), Positives = 306/645 (47%), Gaps = 60/645 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVV--TWCIGHLLEQAQPDAYDSRYAR 60 L IAEKPSL R I + G+ + GH + PD Y +A+ Sbjct: 8 LLIAEKPSLMREIQSA----------YHTFGHKDTIEFKSFAGHTMGLINPDKYKEEWAK 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDY 118 W+LA LP+VP+K+ +P IK+ + I++ DP REGQ + D Sbjct: 58 WDLATLPLVPDKFLYEPTKDKLDMYKDIKKAIKNGNYDYIINGCDPGREGQHIFFSFYDS 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADWLYGINM 176 + V+R +DL + ++RA+D LR +E + ++ RA DWL G+N Sbjct: 118 IGC----NLPVKRIWHSDLTEKELKRALDNLRDENEPALSNMTKASKLRAYFDWLIGMNF 173 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA++I+G +++GRV TP L ++V R+ EI+NFV K+F+E++A F Sbjct: 174 TRAFSIVGGKK-----MNLGRVMTPALKVLVDRELEIKNFVPKNFWEIEADFGKYKGVHF 228 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 +D + + + A+ +++ +S + V N +++ + AP SLSA Sbjct: 229 N------------EDGDTQFWKQEDAQKIIDSLST-DSTVKIVNQEKDVKYAPQLHSLSA 275 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA +G + Q L+I Q LYE K ++YPR+D +L + + A+M + P Sbjct: 276 LQNEANSVYGYTMQETLNITQTLYE-KKFVSYPRTDSSHL-TKAISNDFAIMLRPLQNIP 333 Query: 357 DLLPQP---------VVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLI 406 +L + + D + DDKKV H+AI+PT S LT+ E VY LI Sbjct: 334 ELADKTKAIINDSKILSDIANNKKYVDDKKVSDHYAIVPTGLSPDFGRLTDKEINVYMLI 393 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 A+++L F P V +K + + F L G+ L K +D LP Sbjct: 394 AKRFLSIFLPPMVSQKTSVVTENNGHLFKTSGSVLESIGFMALYNYKAQD-----NMLPP 448 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + KG+ + +K E++ +QT P +TD TL AM RF+ D +LK++L+ G+GT A Sbjct: 449 LKKGEMVSLKKAELITKQTSKPGRYTDRTLNIAMENAGRFIDDDELKEVLKEAKGIGTPA 508 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQ 585 TR GI+E L + +K + +T+ G + SL T P++TA WE L++I Q Sbjct: 509 TRGGIVEKLVSLNMIERKKKSFFATEYGIGIIQSLNGHDITSPELTAKWEQKLSEIEANQ 568 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV----RQFRGIVAPGSGGSA 626 F + ++ + + ++ K+ V + P G Sbjct: 569 FDPNVFYKEMIAYIQKEVEDLKKLKVFVSSSKDSLGSCPKCGKHV 613 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 490 bits (1262), Expect = e-137, Method: Composition-based stats. Identities = 150/668 (22%), Positives = 270/668 (40%), Gaps = 79/668 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ A+ I L K V GH+ + D Sbjct: 1 MNVVIVESPAKAKTINKYLGK-------------DYTVLASYGHVRDLPPKDG------- 40 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP K+L+ I + EA ++ A DPDREG+ + VL+ L+ Sbjct: 41 ---SVLPDDDFAMSWSVDSKSQKRLSEIASAVKEADRLILATDPDREGEAISWHVLEVLK 97 Query: 121 LAPEKRQQ-VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + ++R + N + ++ A+ R E PL + LAR D+L G ++ Sbjct: 98 KKRVLKDKKIERVVFNAITKSSILEAMKNPRELDE--PLVDAYLARRALDYLVGFTLS-- 153 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +L R G S GRVQ+ L LV +R+ EIE F +++++ + A++ TP + A Sbjct: 154 -PVLWRKL--PGARSAGRVQSVALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + + + + + A + + G V++ K + + PF+ S LQ Sbjct: 211 LTGFDGQKITRLD---IKNEQEATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G +A + + QKLY ET LITY R+D + +E V+ S Sbjct: 268 EASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVI--AS 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + +P+ + + +AH AI PT + L E+ A++Y LI Sbjct: 326 RYGDEYVPEKPRMYSSKAK----NAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGS-KERDEENDGT 462 ++ + AV + +++D G A + G+ TL K+ +E+ + Sbjct: 382 KRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESK 441 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + +GD L + E + T+PP FT+ATL+ M + + Sbjct: 442 RLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLT 579 G +T A ++ L RG++ + + D G+ + L + R D TA E L Sbjct: 485 GRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 +IS ++ ++ +++ D+ + + + K + Sbjct: 545 KISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGS--DPR 602 Query: 640 KSPPADEV 647 K P D Sbjct: 603 KCPKCDTG 610 >UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tasmaniensis RepID=B2VAT6_ERWT9 Length = 722 Score = 487 bits (1255), Expect = e-136, Method: Composition-based stats. Identities = 199/659 (30%), Positives = 322/659 (48%), Gaps = 46/659 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA+ +K G+ EC VVTWC GH+L P A + Y Sbjct: 1 MILTIAEKPELAEIIANAFGNAVKK-QGYYECAGNNVVTWCFGHMLVLTPPAAVNPSYEV 59 Query: 61 WNLADLPI----VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W + DLP+ V + + V +Q +I L ++S ++HAGDPD EG+LLV E+L Sbjct: 60 WKMDDLPMDLTAVSHQVKATENGYVERQYKIICDLLKKSSSVIHAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSN--SEFVPLCVSALARARADWLYGI 174 + V+R L+NDLN A ++AID++ +F+ L + ALARA+ D ++G+ Sbjct: 120 ----WLENYTKPVKRLLLNDLNINAAKKAIDKMEDGNSDKFIRLALKALARAKGDQIFGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 NMTR +T+L + G +G L+ GRVQTP+LGL+V R + + V +++V + D Sbjct: 176 NMTRYFTLLSQRLGGRGKLTCGRVQTPMLGLIVARYKAFNSHVKSYYYDVSSTHNFLKDF 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 I A +G+++ +A+ + G+P+ V S + ++ +APLPF L Sbjct: 236 PLKIIPNDDFAV------DGKIIDPDVAQKIKEACEGKPSSVASVKVEDKATAAPLPFDL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 LQ K +S L++ Q L + I+Y RSDCRYL + +NA+ + Sbjct: 290 LGLQSYMLKD-KISPDETLELTQSLRSNYSAISYNRSDCRYLSSDQHEEAPDTLNALKKY 348 Query: 355 A-----PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIAR 408 D++ D + + ++DK + +H AIIPT + ++ E KVY I Sbjct: 349 VGDGALNDVINNTSFDISRKGKAFNDKNITSHTAIIPTPNPRGLEKMSAKERKVYEAIVL 408 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG------- 461 +YL+QF D ++ + +D A ++ A A L AGW ++ + N+ Sbjct: 409 RYLLQFVDDKKYKSAKVVVDCAGYQYSASATRLISAGWSSIEADDSDESNNNDGEDSQPL 468 Query: 462 -TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR--- 517 + ++ G++ C + + +T+P +T T L + ++++V D +KK+L Sbjct: 469 FESISALSNGEQSSCTGVIISKAETKPLPLYTMKTFLEDLKRVSKYVSDPRIKKLLLSKD 528 Query: 518 -----ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTA 572 G+GT ATR+ II+ L G+ T + + T+ G SLP T PDMTA Sbjct: 529 EGKKGERGGIGTPATRSTIIKNLENTGYYTIQSNKLIPTEKGIKFIESLPVSVTAPDMTA 588 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLI-----DQAKRTPVRQFRGIVAPGSGGSA 626 W T I + + DF+ + T+ +L+ + K+ Q +G GG Sbjct: 589 LWHEQQTMILDGEMELSDFIININQTVAELMKADVTEGMKQVADSQPKG-KCFCCGGDM 646 >UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4ZCE3_EUBR3 Length = 1273 Score = 486 bits (1250), Expect = e-135, Method: Composition-based stats. Identities = 184/705 (26%), Positives = 319/705 (45%), Gaps = 73/705 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A VL R DG+IE G V++WC+GHL+ P++YD +Y +W Sbjct: 5 LIITEKPSVAQEFAKVLRVSGR-NDGYIENGE-YVISWCVGHLVGLVYPESYDMKYKKWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +P++++ SV KQ N++ L + + AGD +EGQ + + + ++ Sbjct: 63 LEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + R I+ + + R I + S + L S + R D+ GIN +R Sbjct: 123 VREGMEE--LRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVM 180 Query: 181 T-----ILGRNAGYQG--VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 + +L AG + ++VGRV T VLG+VV R+ EI NF F+ V Sbjct: 181 SVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFTDAGV 240 Query: 234 ERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 E A W+ E ++ +E A ++ ++G+ A + S + AP Sbjct: 241 E---AEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAP 297 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L F+L+ LQ E +K+F +S L + Q LYE KL TYPR+D R L + Sbjct: 298 LLFNLAELQAECSKKFKISPDETLQVAQDLYE-KKLTTYPRTDARVLSSAVAKEIGKNIG 356 Query: 350 AISVHAP------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKV 402 + P ++ + + + DD KV H+AIIPT + + LT + V Sbjct: 357 RLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAV 416 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD--EEND 460 + LI R++L F P A + + +D+ K F A ++ L G+ + ++ EE++ Sbjct: 417 FELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESN 476 Query: 461 GTPL----------------------------------PVVAKGDELLCEKGEVVERQTQ 486 L + GDE+ C+ + +T Sbjct: 477 ARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTS 536 Query: 487 PPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR 546 PP+ +T +++ AM + ++D++L++ ++ + G+GT ATRA II+ L + G+L + Sbjct: 537 PPKRYTSGSMVLAMENAGQLIEDEELREQIKGS-GIGTSATRAEIIQKLVRIGYLNLNKK 595 Query: 547 Y--IHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQ 601 + G+ +F + P MTA+WE L I+ + ++ L + + Sbjct: 596 TQILTPESLGEMVFEVVYMTVPALLNPKMTANWEKGLDGITRGTVDFWEYRGKLESFIRK 655 Query: 602 LIDQAKRTPVR-QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 ++ +R + ++ +G +A + AA R++ K P Sbjct: 656 ETEKMIEQNLRPEIADRISSFAGKNA--RGAAARRKIGVKCPVCG 698 >UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=B5EJ79_ACIF5 Length = 851 Score = 486 bits (1250), Expect = e-135, Method: Composition-based stats. Identities = 140/672 (20%), Positives = 259/672 (38%), Gaps = 84/672 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I L G+ V GH+ + + + Sbjct: 4 QLVIVESPAKAKTIQKYL-------------GDDFQVLASYGHVRDLQPKEGAVDTEHDF 50 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ- 120 + + P + ++ I + L A ++ A DPDREG+ + +++ L+ Sbjct: 51 AM----------RYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRE 100 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + QR + +++ +AV+ AI R + + L + AR D+L G N++ Sbjct: 101 RQLLGDKPTQRVVFHEITKKAVQEAIAHPREIA--MDLVNAQQARRALDYLVGFNLS--- 155 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L R + LS GRVQ+ L L+ R+ EIE FV+++++ + + + FT Sbjct: 156 PLLWRKV--RPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSA-FTGRL 212 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVV----NRISGQPAIVTSYNDKRESESAPLPFSLSA 296 + + E+ + A+ + + + Q V K PF+ S Sbjct: 213 THWQNKKL---EQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTST 269 Query: 297 LQIEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 LQ EA+++ G +A + + Q+LY ET LI+Y R+D L EE A ++ Sbjct: 270 LQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFID 329 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYN 404 + + +P+ R + +AH AI PT + L + ++Y+ Sbjct: 330 --GYYGSEFVPE----TPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYD 383 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKG-KFVAKARFLAEAGWRTLL--GSKERDEENDG 461 L+ ++ + A +++D A + G+ + G + DE+ Sbjct: 384 LVWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESN 443 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 LP + GDE L + + T+PP ++DATL+ + G Sbjct: 444 RILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLE-----------------AHG 486 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVL 578 +G +T A II+ L R ++ + R H TD G+ + L TA E L Sbjct: 487 IGRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDEL 546 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQ----AKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 +S + ++Q + L+D+ ++ + P G + Sbjct: 547 DAVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHG 606 Query: 635 KRSAKKSPPADE 646 + A P Sbjct: 607 RFVACSGYPECN 618 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 485 bits (1248), Expect = e-135, Method: Composition-based stats. Identities = 164/657 (24%), Positives = 289/657 (43%), Gaps = 55/657 (8%) Query: 3 LFIAEKPSLARAIADVL--PKPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPDAY 54 L IAEKP++AR IA L +P RK G F G +V +GHL A Sbjct: 4 LIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPK--- 60 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 ++ + + D+ VP + + + + A E V A D D EG+++ Sbjct: 61 -TKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYT 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L Y + +R + L + + +A L S F + + +AR DW +G+ Sbjct: 120 ALKYACGVDPSKA--KRMKFSALTKKDLLKAWYNLESTINF-GMADAGIARHVLDWYWGV 176 Query: 175 NMTRAYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 N++RA T + R +G VLS GRVQ P L +V R++EI+NF ++ +K ++ Sbjct: 177 NLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKM-VLEKNG 235 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +++TA++ E+ R+L A+ +V PA V + K+++ P+PF Sbjct: 236 QQYTAVY-----------EKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFD 284 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L LQ EA FG S + L++ QKLYE L +YPR+ + LP+ + R + N + Sbjct: 285 LGTLQREAYSAFGYSPKKTLELAQKLYE-RGLTSYPRTSSQKLPK-NLNFRSILQNLAKL 342 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLM 412 ++ + K AH AI PT LT++EA +Y+LI R++L Sbjct: 343 PEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEANLYDLIVRRFLA 402 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F AV + ++ +F+ + GW + G + +E LP +G+ Sbjct: 403 LFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDE---AILPAFKEGEP 459 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + + + +++T+PP ++ A ++ M + +GT+ATRA I+ Sbjct: 460 VKVLQIKREKKKTKPPARYSPAAVIKRMEDLG-----------------IGTKATRAQIL 502 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQ 589 E L+ RG++ K + I T G + +L ++T +E + +I + Sbjct: 503 ETLYSRGYIEGKKK-IKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKD 561 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 ++ L +++ Q K + + ++ G K+ A R + K+ +E Sbjct: 562 RVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKELSETEE 618 >UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_SPHTD Length = 769 Score = 485 bits (1248), Expect = e-135, Method: Composition-based stats. Identities = 147/677 (21%), Positives = 264/677 (38%), Gaps = 89/677 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I +L + G V +GH+ + P + + Sbjct: 62 LVIVESPAKARNIGRILGR-------------GYTVKASMGHVRDL--PKSKLGVETDRD 106 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 A + ++P +K + ++ + EA EI+ A DPDREG+ + +++ Sbjct: 107 FAPVYLIPR--------DKSKVVKELRADVKEAREILLATDPDREGEAIAWHLVEA---T 155 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V+R + +++ P+A+ A+ R + L + AR D L G ++ + Sbjct: 156 DPGDKPVRRIVFHEITPEAIREALRNPRGID--MRLVEAQQARRILDRLVGYEIS---PL 210 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L R + LS GRVQ+ L LVV R+ EI+NFV ++++ + A + Sbjct: 211 LWRKV--KRGLSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAELAKREAVNGRKPKPF 268 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ L +V + G V K PF+ S LQ EA+ Sbjct: 269 VASLSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQEAS 328 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ + + + I Q+LYE T LITY R+D + A V+ + Sbjct: 329 RKLNMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVI--AERY 386 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN--------LTENEAKVYNLI 406 P+ LP P + R +AH AI PT + + K+Y LI Sbjct: 387 GPEFLPD---RPPVYTRKAKG-AQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLI 442 Query: 407 ARQYLMQFCPDAVFRKCVIELDIA------KGKFVAKARFLAEAGWRTLLGSKERD---E 457 ++++ +AVF +++D +F A + G+ + D + Sbjct: 443 WQRFIASQTRNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIYREGRDDDTVD 502 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E D LP + +G+ L + + TQPP FT+ATL+ A+ + Sbjct: 503 EIDREALPPLTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELG------------- 549 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHW 574 +G +T A I L R ++T + R ++ T+ G + L + + T+ Sbjct: 550 ----IGRPSTYAPTIATLQARNYVTVEQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKL 605 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKK 629 E L QI+ + + ++ G ++ +++A++ R + V G K Sbjct: 606 EDELDQIASGEQSWVPMVRAFYGPFHETVERAEKEIGRVKVADEPTDEVCEKCGRPMVIK 665 Query: 630 KAAPRKRSAKKSPPADE 646 + A P Sbjct: 666 LGRYGRFLACSGFPECR 682 >UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=A8U7S1_9LACT Length = 701 Score = 484 bits (1247), Expect = e-135, Method: Composition-based stats. Identities = 176/641 (27%), Positives = 289/641 (45%), Gaps = 60/641 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKPS+ + IA VL K IE G +VTW +GHLL P+ Y +A Sbjct: 11 MKTLIIAEKPSVGKEIARVLGATQ-KSKTHIE-GKDVIVTWALGHLLGLKMPEEYKKEWA 68 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W+L LP++PEK P + QL IK+ V A D REG+L+ +L+ Sbjct: 69 TWDLNTLPLIPEKMLTTPLKNTRSQLKAIKQLADRKDIGSAVIATDAGREGELVARWILE 128 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y+ + ++R I+ +A++ ++L+ + ++ L SA+AR+ ADWL G+N+T Sbjct: 129 YVHF----NKPIKRLWISSQTDKAIKEGFNQLQPSKKYDTLYDSAVARSEADWLIGLNVT 184 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ YQ LS GRVQTP L +V +++ +I++FV + F+ V+ I Sbjct: 185 RALTV-----KYQDSLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLVI--------- 230 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + R AE +V + + IV +K+ + APLP+ L+ L Sbjct: 231 ----DGKKATIQDSALRKFSERQKAEDLVASLKNKSVIVKEIKEKQSIQQAPLPYDLTEL 286 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA R+ SA+ L + Q LYE HK+++YPR+D +YL ++ + AI APD Sbjct: 287 QREANLRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMIGTMKERVAAIQNFAPD 346 Query: 358 LLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 + + + ++ KV HH IIPT + +E K+Y ++ +++ F Sbjct: 347 EVKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPEKMEADELKIYRMVVERFIGLF 406 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P K I A F + + E GW+ E ++L Sbjct: 407 LPAYNVSKTTIVFSAATTLFSLQQEEVIEKGWKK---------EVQKQSEKGYQLNEQLT 457 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 + + T+ P ++ TLL M +GLGT ATRA IIE Sbjct: 458 QPTYTIQMQLTEAPARLSEGTLLQNMEK-----------------NGLGTPATRAEIIEK 500 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 L K + + + +T G+ L + P++T WE L +I++ + + F++ Sbjct: 501 LIKSDLMERNQNKLSTTPKGQQLLTLVNPALVTPELTRKWEEALEEIAKGTLKKEVFLKQ 560 Query: 595 LVGTLYQLIDQAKRT----PVRQFRGIVAPGSGGSADKKKA 631 + +L+ + K + + P G ++ Sbjct: 561 IKNETARLVTEIKNSTETYKDHALTTKICPDCGELLKERSG 601 >UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU1_CLOCL Length = 730 Score = 483 bits (1244), Expect = e-135, Method: Composition-based stats. Identities = 178/657 (27%), Positives = 309/657 (47%), Gaps = 53/657 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IA+ L RK DG++E GNG +TW GHLL+ YD + A+W Sbjct: 3 KVIIAEKPSVAKNIAEALKSNIRK-DGYLE-GNGYYITWAFGHLLQLYDAKDYDEKMAKW 60 Query: 62 NLADLPIVPEKWQLQPRPS----------VTKQLNVIKRFLH--EASEIVHAGDPDREGQ 109 + + P +P+ ++ + + KQL +I+ ++ + ++ A D DREGQ Sbjct: 61 KMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ D + YL++ ++ V R L N+ V + +++++ N+E L + ++R AD Sbjct: 121 IIGDIITGYLKV----KKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWAD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W GIN+T T+ + G L++GRV P L ++ RD+EI NFV ++F++ A Sbjct: 177 WTIGINLTSVATLKYQR-GKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T + + + E + + + R + + ++ G ++ +++ E P Sbjct: 236 TSDNIEYEGAYIEKEQEKEQEKFKE----REKLDEISKKMKGCTGVIVDKQTEKKKEYPP 291 Query: 290 LPFSLSALQ-IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE K ITYPR+ L E V+ Sbjct: 292 YLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYE-KKYITYPRTASVVLEESLADRAAKVL 350 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + P Q V R +D+ KV++H AIIPT L+ +E KVY+ I Sbjct: 351 NTLKKSLPF---QEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKT-LSGDEEKVYSAIKN 406 Query: 409 QYLMQFCPDAVFRKCVIELDIAK----GKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++ QF P A + I I G F++K + GW+ + + +D T L Sbjct: 407 RFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKD-----TIL 461 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR---ATDG 521 P V DE+ K +V T+PP+ T+ TLL M + ++ +++ + Sbjct: 462 PFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFS 521 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQ 580 +GT ATRA I+ L G++ +G+ + ++ G L + P + + T E L Sbjct: 522 IGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLAD 581 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQA---KRTPVRQFRGI--------VAPGSGGSA 626 + + + +DF++ + I+Q K + Q+ G P G Sbjct: 582 MEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDV 638 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 482 bits (1240), Expect = e-134, Method: Composition-based stats. Identities = 146/672 (21%), Positives = 260/672 (38%), Gaps = 82/672 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ L K V +GH+ + + Sbjct: 5 LVIVESPAKAKTISKFLGKKF-------------TVKASMGHVRDL-PKSQFGVDVKNG- 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P+ ++ + + K L + +A +++ A DPDREG+ + + + L++ Sbjct: 50 -----FKPKYITIRGKGDIIKDLRA---AVKKADQVLIASDPDREGEAIAWHLQNLLEID 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R N++ QA+++A+ R + AR D L G N++ + Sbjct: 102 ENESC---RIEFNEITKQAIQKALQHPRPIDR--NRVNAQQARRILDRLVGYNLS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L R + LS GRVQ+ + L+ R+EEI++FV ++++ + A V + F Sbjct: 154 LWRKI--KKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLI- 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 ++DE+ + + + V+ + G V K +S PLPF S LQ EA Sbjct: 211 -----KFRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAY 265 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ +A+ + + Q+LYE T LITY R+D + + + Sbjct: 266 RKLNFTARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYI--VERF 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + P + K DAH AI PT+ LT ++ K+Y LI + Sbjct: 324 GARYAGRET--PPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSR 381 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVA 468 +L AVF I++ + F A + G+ + D E+ + LP + Sbjct: 382 FLASQMKPAVFDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELK 441 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+E+ + TQPP +TDA+L+ A+ G+G +T Sbjct: 442 EGEEIEARSLTPRQHFTQPPPRYTDASLVRALE-----------------EKGIGRPSTY 484 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQISEKQ 585 A I+E + KRG++ ++ + T+ G + L + D TA E L I E + Sbjct: 485 APIVETILKRGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGE 544 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTP-----VRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 + ++ G +++A+ + G S K K A Sbjct: 545 LDWIKVLESFYGPFKNTLEKAENEIGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACP 604 Query: 641 SPPADEVGSGAI 652 P + Sbjct: 605 GFPECRSTKPLL 616 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 481 bits (1238), Expect = e-134, Method: Composition-based stats. Identities = 146/674 (21%), Positives = 266/674 (39%), Gaps = 84/674 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G G V GH+ P S N Sbjct: 5 LVIVESPAKAKTIEKFL-------------GPGYKVLASYGHVRAL--PSKQGSVDVEHN 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + L V P K + ++K+ ++ E++ A DPDREG+ + +L+ L + Sbjct: 50 FSPLYHVL--------PESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGID 101 Query: 123 PEKRQQ-VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + V+R +++ A++ AI + L + AR+ D+L G N++ Sbjct: 102 ENAKSPEVKRVTFHEITKGAIQEAIS--KPGHIARELVDAQQARSILDYLVGFNLSPF-- 157 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 L + Y LS GRVQ+ L L+ R++EI+ F A++++ ++ + T F A Sbjct: 158 -LWKKIRYG--LSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLY 214 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + + + A +V I + V + + PF+ S LQ EA Sbjct: 215 AVDGNSLGKFD---INQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEA 271 Query: 302 AKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +++ G SA+ + + QKLYE LITY R+D L + ++ + + Sbjct: 272 SRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRM--Y 329 Query: 355 APDL-LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 D L +P V +N+ + +AH A+ PT+ S+ + L+ ++ K+Y LI + Sbjct: 330 GEDYALDKPRV---FKNKAKN--AQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQ 384 Query: 409 QYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEEN----DGTP 463 + + A +++ + F A + + G+ L +E+ + Sbjct: 385 RTVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGT 444 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + L C++ + + TQPP FT+A+L+ + G+G Sbjct: 445 LPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLE-----------------EHGIG 487 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQ 580 +T A II L R ++ + R ++ D G + L + D TA E L Sbjct: 488 RPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDA 547 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQ-----AKRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 IS + +Q ++ + + +K+ + + P G K + Sbjct: 548 ISRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGR 607 Query: 636 RSAKKSPPADEVGS 649 A P Sbjct: 608 FLACSGFPDCRYTE 621 >UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRI8_9FIRM Length = 713 Score = 481 bits (1238), Expect = e-134, Method: Composition-based stats. Identities = 128/676 (18%), Positives = 263/676 (38%), Gaps = 89/676 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I L K V +GH+ + + + Sbjct: 17 HLVIVESPAKAKTIEKYLGK-------------DYSVVASVGHIRDLPKSKLGVDVDNNF 63 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + + + +K+ + + A DPDREG+ + + L + Sbjct: 64 EP----------KYENKKDKAALIKELKKDAKASDIVYLATDPDREGEAISWHLAHVLGI 113 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 +P+ R +++ +E + R+ + L + AR D + G ++ Sbjct: 114 SPDAPV---RVTFSEITKSGIEAGMSHPRTLD--MDLINAQQARRILDRIVGYKLSPF-- 166 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 L + + LS GRVQ+ + L+V R++EIE+F A++++ + A +++ + R Sbjct: 167 -LWKKV--RRGLSAGRVQSVAVRLIVDREQEIESFEAQEYWSIDAKLLSASSRR-----A 218 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + E+ + L++ + V+ + I+T+ + ++ PF+ S LQ EA Sbjct: 219 FPAKLTEVKGEKFKALNKEETDKVLAMLENGEFIITNIKNSTRKKTPAPPFTTSTLQQEA 278 Query: 302 AKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 +++ +A+ + Q+LYE +ITY R+D + +E A ++ S Sbjct: 279 SRKLSFNARRTMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMIE--ST 336 Query: 354 HAPDLLPQPVVDPDIRNRCWDDK--KVDAHHAIIPT-----ARSSAINLTENEAKVYNLI 406 + + LP + R + K DAH AI PT L+ ++ K+Y LI Sbjct: 337 YGKEYLP-------SKPRVFKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLYKLI 389 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 +++ + + +++ + F A + G+ L + ++E +G LP Sbjct: 390 WERFMASQMENQLLDTKAVDITCGECLFKANGYTVKFDGFTKLYEESKDNDEEEGGALPA 449 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + G++L ++ + TQPP +T+A+L+ A+ +G+G + Sbjct: 450 LEVGEKLKVKELTGNQHFTQPPPRYTEASLIKALE-----------------ENGIGRPS 492 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISE 583 T A I + R ++ ++ + + T G + + E TA ES L +I Sbjct: 493 TYAPTIATILDRHYVEREAKQLKPTSLGIVITDLMKGHFERIVDAKFTAQMESDLDKIEA 552 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKR-------TPVRQFRGIVAPGSGGSADKKKAAPRKR 636 + + D + +++ +A++ + IV G K K Sbjct: 553 GKADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKIPDEPTDIVCDKCGKPMVIKIGPYGKF 612 Query: 637 SAKKSPPADEVGSGAI 652 P + + Sbjct: 613 LGCSGFPECKNTKRIV 628 >UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp. enterica serovar Agona str. SL483 RepID=B5EWF7_SALA4 Length = 726 Score = 481 bits (1237), Expect = e-134, Method: Composition-based stats. Identities = 195/631 (30%), Positives = 313/631 (49%), Gaps = 39/631 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA +K G+ EC N VVTWC GH+L PD + Y Sbjct: 1 MILTIAEKPELAEIIAKAFGGEVKKS-GYWECANNNVVTWCYGHMLVLTPPDKVNPSYKT 59 Query: 61 WNLADLPI----VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W ++DLP+ V + + V +Q +I L ++S +++AGDPD EG+LLV E+L Sbjct: 60 WVMSDLPMDLTEVSHEVKTTENGYVERQYKIITDLLRKSSSVINAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS--EFVPLCVSALARARADWLYGI 174 + VQR L+NDLN A ++A+ +L+ + +F+ L + ALARA+ D +YG+ Sbjct: 120 ----WKENYNKPVQRLLLNDLNVNAAKKALSKLQDGNSEKFMRLALKALARAKGDQIYGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 NMTR YT+L R G G L+ GRVQTP+LGL+V+R E+ +N V ++++V + Sbjct: 176 NMTRYYTLLNRQHGGNGKLTCGRVQTPMLGLIVKRYEDFKNHVKSNYYDV-----YSSHN 230 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 +++ A + + +G++L +AE++ + +P+ V + + PLPF L Sbjct: 231 ILKSVYLKLIADDKFA-TDGKILSPEVAENIKSACVMKPSTVVVAKVEDKHTPPPLPFDL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETH-KLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LQ K + ++I QKL I+Y RSDCRYL + + A + A+ Sbjct: 290 LGLQAYMLKD-NIDPTETMEITQKLRSKEIAAISYNRSDCRYLTSDQYDEAPATLEALKK 348 Query: 354 HAPDLLPQPVVDPD-----IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIA 407 + + + V++ + + ++D V AH IIP+A ++ LT E KVY I Sbjct: 349 YISGGILESVINNNGFDIKRKGIAFNDDNVSAHTGIIPSAEPRNLDKLTSKEKKVYEAIV 408 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT----- 462 +YL+QF D ++ + ++ +F A L GW L D+ + Sbjct: 409 LRYLLQFLDDKKYQSAKVIIECEGYRFGGSATKLVSPGWTALEAEDSDDDSAEENTDSAF 468 Query: 463 -PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR---- 517 + + D +C V +++T+P +T T L + ++R+V D +K++L Sbjct: 469 DAISAMKVDDVGVCNDVRVDKKETKPLPVYTMKTFLEDLKRVSRYVTDPHIKQLLLSKDK 528 Query: 518 ----ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAH 573 G+GT ATRA II L G+ T + + T+ G +LP + PDMTA Sbjct: 529 GKKGERGGIGTPATRATIISNLESTGYFTVQNGKLIPTEKGIGFIKNLPVAVSAPDMTAL 588 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLID 604 W I E DF+ + T+ +L++ Sbjct: 589 WHEQQMMIMEGDLELGDFIININNTVKELMN 619 >UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ2_FIBSS Length = 1049 Score = 481 bits (1237), Expect = e-134, Method: Composition-based stats. Identities = 198/682 (29%), Positives = 322/682 (47%), Gaps = 66/682 (9%) Query: 1 MRLFIAEKPSLARA-----IADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 M L +AEKPS+A + + + +GDG + G +TWC+GHL+ A DAY Sbjct: 1 MILLVAEKPSVANQHYKPMLERIEGEKFTQGDGCL-IGKNHCITWCVGHLITLAPLDAYP 59 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L++LP++PEK++L S KQL V++ + A +V+ D REG L+ D + Sbjct: 60 GFEGGWRLSNLPLLPEKFKLMEIESTRKQLGVVRDMMARADVLVNGADAGREGNLIFDLI 119 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 LDY +++Q++R +N + +++A L +E + L +A R RADW+ G+N Sbjct: 120 LDYT--PDFRKKQIKRLWVNSYVAKDLDKAWKNLEDATERLNLSYAARLRQRADWMVGLN 177 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV-------KAHI 228 TRAYT+ AG ++SVGRVQTP L LVV RD +E F ++ V +A + Sbjct: 178 ATRAYTL---TAGRGKMISVGRVQTPTLNLVVERDAIVEQFKELFYYSVVGTWKGFQAQL 234 Query: 229 VTPADERFTAIWQPSEACEPYQDEEGRLL-----HRPLAEHVVNRIS-GQPAIVTSYNDK 282 V + + D++ L A+ V+++ S + A + + + Sbjct: 235 VKSETKEEKGDSGTPVDEKVAADKQSNLKVAIFEKEEPAQAVIDKCSPPEEAAIAKVDIQ 294 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 ++ + PF L+ LQ E KRF SAQ VLD Q LYE KL+TYPR+D +YLP+ Sbjct: 295 QKKQFPQKPFDLTELQKEGNKRFKYSAQQVLDCAQNLYE-KKLLTYPRTDSQYLPDTMQQ 353 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 +A+ ++ + + D + + KV H AIIPT NL E E + Sbjct: 354 EAYALAQRLASPQEKSV---MRDGNENFVFINSSKVTDHFAIIPTGEEPQ-NLPEMEENI 409 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLL----------- 450 Y L +++ + V+ + + LD A F K + + G+R L+ Sbjct: 410 YKLAKERFVQAWLKPYVWSEMEVLLDAANAEIFRLKLKRNEDLGFRALVKEEKKKPSKKK 469 Query: 451 ------------------GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFT 492 D N P GD + E+ +++ P++FT Sbjct: 470 KGDAGSESGDAKGADSEGKGDGDDITNIVETFPEWNLGDHAPFDSLELQKKKKSKPKYFT 529 Query: 493 DATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTD 552 +ATLL+AM + +++++L + ++ GLGT AT+AGIIE L KRGF+ + Y+ ST Sbjct: 530 EATLLAAMKTAGKQIENEELAEAMKE-RGLGTPATQAGIIETLKKRGFIEAQKNYLVSTQ 588 Query: 553 AGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 G+ + + E P+MT WE L+Q+ + + +F +V + +L + ++ Sbjct: 589 RGREVIELMDEKVKSPEMTGEWEFKLSQVEKGKLTPIEFRDGIVNYVKELFEHLRQKYGS 648 Query: 613 QFR------GIVAPGSGGSADK 628 QF I P + Sbjct: 649 QFERETVTDAIPCPKCSSPLEI 670 >UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0B0_THERP Length = 744 Score = 480 bits (1236), Expect = e-134, Method: Composition-based stats. Identities = 139/675 (20%), Positives = 262/675 (38%), Gaps = 88/675 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR IA L G G V +GH+ + + + Sbjct: 37 LVIVESPAKARTIARFL-------------GPGYTVKASMGHVRDLPKSKLGVDVAQNFQ 83 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P L+ + V K+L + A E++ A DPDREG+ + +++ + Sbjct: 84 -------PTYTVLKEKLPVVKELQ---ESVQRARELILATDPDREGEAIAWHLIEATRAH 133 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V+R + +++ +A+ A+ R + L + AR D L G ++ + Sbjct: 134 D---KPVRRIVFHEITEEAIREALAHPRGID--MRLVNAQQARRVLDRLVGYEIS---PL 185 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L R + LS GRVQ+ L LVV R+ EI+ FV ++++ ++ +V + + Sbjct: 186 LWRKV--KSGLSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPFA 243 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + A + E+ L + A V + V S ++++ PF S LQ EA Sbjct: 244 A-ALVRVRGEKPDLPNEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAG 302 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ + + Q+LYE + LITY R+D + V+ + Sbjct: 303 RKLRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVI--AARW 360 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP+ + + +AH AI PT + LT + ++Y LI + Sbjct: 361 GADFLPERPPVYAKKAK----GAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWER 416 Query: 410 YLMQFCPDAVFRKCVIELDIA-------KGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 ++ A++ +E+ A + G+ + + ++E D Sbjct: 417 FIASQMAPAIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDEL 476 Query: 463 ---PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 PLP +A G+ L + TQPP +++ATL+ + + Sbjct: 477 DQRPLPPLATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELG--------------- 521 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 +G +T A IE L +R ++ + R + T+ G + L + T+ E Sbjct: 522 --IGRPSTYAPTIETLKQRRYVVVEDRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEE 579 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKA 631 L +I+ + + ++ ++ +++A++T R Q G V G K++ Sbjct: 580 ELDEIAAGERDWVPVVREFYEPFHRQVEEAEQTMERVRLADQPSGEVCELCGRPMVIKES 639 Query: 632 APRKRSAKKSPPADE 646 + + P + Sbjct: 640 RFGRFLSCSGFPECK 654 >UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW2_ROSCS Length = 836 Score = 478 bits (1231), Expect = e-133, Method: Composition-based stats. Identities = 136/665 (20%), Positives = 255/665 (38%), Gaps = 99/665 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ AR I L G+G V +GH+ + + + A + Sbjct: 4 KLVIVESPAKARTIQKYL-------------GSGYRVEASMGHVRDLPKSNLGVDLEANF 50 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + P K + +++ + +A + A DPDREG+ + + + ++ Sbjct: 51 APV----------YEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKI 100 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + V R + ++ P AV A+ R L + AR D L G ++ Sbjct: 101 --PRDKPVYRVVFTEITPGAVRSAMASPRDIDR--RLVDAQQARRVLDRLVGYKLSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA-----DERF 236 R LS GRVQ+ + L+V R+ EIE FV ++++ ++A ++ + F Sbjct: 157 EKVRRG-----LSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAF 211 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A+ + E+ + A+ ++ + G IV + + S PF+ S Sbjct: 212 RAMLIERSGKKL---EKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTST 268 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE---------THKLITYPRSDCRYLPEEHFAGRHAV 347 LQ EA ++ G SA+ + + Q+LYE LITY R+D + E V Sbjct: 269 LQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRV 328 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKV 402 + LP P + + +AH AI P T LT ++ ++ Sbjct: 329 IR--ERFGEAYLPAK--PPVYKTKAKG--AQEAHEAIRPTLSRRTPEQVQPYLTSDQYRL 382 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIA-----------KGKFVAKARFLAEAGWRTLLG 451 Y+LI ++++ AVF V+++ F A L G+ + Sbjct: 383 YDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYN 442 Query: 452 ---SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 + ++E+ LP++ +G+ L + V+ T+PP FT+A+L+ + + Sbjct: 443 VSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLG---- 498 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--- 565 +G +T A I + +R ++ + + T G+ + L E Sbjct: 499 -------------IGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSI 545 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-----FRGIVAP 620 T+ E L I+E + + ++ Q + +A+R+ + P Sbjct: 546 VDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCP 605 Query: 621 GSGGS 625 Sbjct: 606 RCNQG 610 >UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL7_CLOBB Length = 718 Score = 478 bits (1230), Expect = e-133, Method: Composition-based stats. Identities = 173/629 (27%), Positives = 302/629 (48%), Gaps = 47/629 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD L RK DG+ G +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADALNIKTRK-DGYF-KGEEYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFLH--EASEIVHAGDPDREGQ 109 + P +PE +Q + + KQ+N+IK + + ++ A D DREGQ Sbjct: 61 RMEKFPFIPESFQYKVKCDNIDRTVEDKGAAKQINIIKSLIEQEDVDGVISATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ +YL + ++ + R L+N+ P V++ + L+ N E L + + R D Sbjct: 121 VIADELFNYLNI----QKPIYRLLLNEWTPDEVKKGMGSLKENKEMQFLQDAGIGRQWTD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T+ + +++GRV P L ++ RD+EIENF A ++++ + Sbjct: 177 WIIGINLTSVSTLKYKFE-ENKTINIGRVLLPTLKIIYDRDKEIENFEATTYYKLTSTFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 ++E F ++ Y+ E + + + +++V + G A + +++ + P Sbjct: 236 NSSNEEFDGLY--------YEKESEKFEDKSVLDNLVKLLDGTNATIIDKQTEKKKDYPP 287 Query: 290 LPFSLSALQ-IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE K TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYE-KKYTTYPRTASVVLEESLEDRARKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + + P + + R +D+ KV++H AI PT L+++E VYN I Sbjct: 347 NTLKIGLPY---EKDIKFIKTKRVFDNSKVESHSAITPTYIKP-NGLSKDEEIVYNAIKN 402 Query: 409 QYLMQFCPDAVFRKCVI----ELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++MQF P A F + I + +G+F++K + GWR + +D T L Sbjct: 403 RFIMQFMPIAEFEETKIRLKPSNEEIQGEFISKGKVQLVEGWRVVEKIDTKD-----TIL 457 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT----D 520 P+V +++ +V + +PP+H T+ TLL M + ++ K+ + + + Sbjct: 458 PMVNVDEKVDIVSNKVNKVTKKPPKHHTEKTLLRVMETCGKGIEGKEDSEEMMQSILNGF 517 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLT 579 +GT ATRA I+ L G++ KG+ + T G + P + + T ES L+ Sbjct: 518 SIGTPATRAETIKKLKDIGYIGTKGKSLICTQLGINIVEIFPVQELLDLEYTGRLESTLS 577 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 I + + + DFM + +D+ K+ Sbjct: 578 DIEKGKFKKSDFMSLIYDFTNNAVDKIKK 606 >UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LRS2_CLOB8 Length = 722 Score = 477 bits (1228), Expect = e-133, Method: Composition-based stats. Identities = 177/659 (26%), Positives = 306/659 (46%), Gaps = 59/659 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD R+ DG+ E GNG +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADAFNVKTRR-DGYFE-GNGYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFLH--EASEIVHAGDPDREGQ 109 P +PE + + + KQL +IK + + IV A D DREGQ Sbjct: 61 RFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ Y ++ ++ + R L+N+ P V+ ++ L+ N E PL + + R +D Sbjct: 121 VIADELFGYFKV----KKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T+ + +++GRV P L ++ RD+EIENF A ++++ ++ Sbjct: 177 WIIGINLTSVSTLKYKFE-ENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T A+E F ++ Y+++ + + + ++R+ G A + + + E P Sbjct: 236 TSANEEFEGLY--------YENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPP 287 Query: 290 LPFSLSALQI-EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE KL TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYE-KKLTTYPRTASVVLEESLKDRAKKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + P + + R +D KV++H AI PT + L+ +E VY+ I Sbjct: 347 NTLKAGLP---YEKDIKFSTSKRIFDSSKVESHSAITPTYIKPS-GLSSDEKIVYDAIKN 402 Query: 409 QYLMQFCPDAVFRKCVIELDIA----KGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++MQF P A F + + L G FV+K + GW+ + + +D L Sbjct: 403 RFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKD-----VIL 457 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILR---AT 519 P + + + +V +PP++ T+ TLL M + ++ D+D +++++ + Sbjct: 458 PKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSG 517 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVL 578 +GT ATRA I+ L G+L KG+ + T+ G+ L + P + + T E L Sbjct: 518 FSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTL 577 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----------TPVRQFRGIVAPGSGGSA 626 + I + + +F++ + Q ++ K+ P P G Sbjct: 578 SDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPV 636 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 477 bits (1227), Expect = e-133, Method: Composition-based stats. Identities = 146/635 (22%), Positives = 257/635 (40%), Gaps = 73/635 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L + E P+ A+ I L G+G V GH+ + D + Sbjct: 6 MKLVVVESPAKAKTIEKYL-------------GSGYQVLASYGHIRDLPSKDGSVNPDNG 52 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 +++ Q P +L I+ + E+ ++ A DPDREG+ + +L+ L+ Sbjct: 53 FSMVW----------QNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLK 102 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R N + AV A+ R L + LAR D+L G ++ Sbjct: 103 TKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDN--DLINAYLARRALDYLVGFTLS--- 157 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 IL R G S GRVQ+ L LVV R++EIE F ++++ V+A + + FT+ Sbjct: 158 PILWRKL--PGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIG-FTSRL 214 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E+ + + AE + + V++ K S + PF+ S LQ E Sbjct: 215 IQWRGQKL---EKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQE 271 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA++ G +A + + + Q LYE LITY R+D + E A + + +P Sbjct: 272 AARKLGFAASHTMRLAQSLYE-EGLITYMRTDGVQMDESAIAAARKTIT--QRYDGGYVP 328 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 ++ + +AH AI PT S + + A++Y LI ++ L A Sbjct: 329 DKPRQYQVKAK----NAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKL 384 Query: 421 RKCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERDEEND------GTPLPVVAKGDE 472 + ++L G+ + + +G+ TL D ND LP++ GD Sbjct: 385 ERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDA 444 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L ++ + TQPP +++A+L+ M + +G +T A +I Sbjct: 445 PLKKEVRADQHFTQPPPRYSEASLVKKMEDLG-----------------IGRPSTYASVI 487 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRYQ 589 ++L R ++T + ++AG+ L L D TA E L +IS + +Q Sbjct: 488 QVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQ 547 Query: 590 DFMQPLVGTLY----QLIDQAKRTPVRQFRGIVAP 620 + ++++Q + + P Sbjct: 548 KVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEP 582 >UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=B3DRF3_BIFLD Length = 719 Score = 475 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 186/689 (26%), Positives = 307/689 (44%), Gaps = 75/689 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY-DSRYA 59 M+L IAEK S+A AIA L + DG ECG +VTW GHL++ A P+ Y D + Sbjct: 1 MKLVIAEKKSVATAIAQALCAAPVQRDGCYECG-QLLVTWAQGHLIDLAMPEDYKDRDWR 59 Query: 60 RWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 +W+L LP+ P +W++ + I R + + +V+A DPDREG+ + Sbjct: 60 KWSLDTLPVDPSGHWQWKISEERGAGSRYRQIVRLIRRTDVDCLVNACDPDREGEAIFRR 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + D + R + L +A++ A ++ SE+ L SA R++ADWL G+ Sbjct: 120 IADMEG----SHKPELRLWVASLEAEAIQAAWRAMKPESEYQGLAWSAEIRSKADWLIGM 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RAY++L Y SVGRVQTP L ++ RD +I N F+ V A + Sbjct: 176 NASRAYSLL-----YNARFSVGRVQTPTLAMIAERDRQIRNHKPVPFWTVIADM------ 224 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 W+ S R+ + A + + + S N +R ++ P + L Sbjct: 225 ---GGWRLSSE---------RIDSKDAAMLLCGQAEHGRFRIMSVNRRRVNDRPPRLYDL 272 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + LQ + ++ +G++A L Q LYE KL TYPR+D RY+ + A++ + + Sbjct: 273 TGLQKDMSRMYGMTAARTLQALQHLYEL-KLATYPRTDSRYITHDDLETLTALLESGRLA 331 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA---INLTENEAKVYNLIARQYL 411 + + + +DKKV H AI+PT + A L ++E KV I R+ Sbjct: 332 QGFVTREGIPGHPRPELTVNDKKVAGHTAILPTMQLDAGKLEGLDDDERKVMTRIVRRMW 391 Query: 412 MQFCPDAVFRKCVIE---LDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP--- 465 D V ++ D +F +++ AGW+ + + E++ T P Sbjct: 392 EAVGDDHVHIVTEVKARLSDDTDREFSSRSDETVSAGWKAVETGHGPEPEDEETANPAGG 451 Query: 466 ------VVAKGDEL-LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + +G + K V E +T+PP+ FT+ATLL+AM +R V+DK+LK L Sbjct: 452 RNVIPSNLMEGGVIRPVGKVTVEEGETRPPKPFTEATLLAAMEHASRCVEDKNLKAALDD 511 Query: 519 TD----GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHW 574 + G+GT ATRA IE L + + +KGR +H+T G+ L + +TA Sbjct: 512 DESHSGGIGTPATRADTIEKLVRSKLVERKGRQLHATTEGERLTDVVEPRLKDVLLTARM 571 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA-------- 626 E L+ + + + M +A R P + A +A Sbjct: 572 EQALSDVEHGKRGPSEVMDMFHR-------EALRIPADATANLKADAVTRTANTDAQEWG 624 Query: 627 -DKKKAAPRKRSAK----KSPPADEVGSG 650 + P +++ + + ++ G Sbjct: 625 DCPRCGQPVRKTGRMWQCSTNKTEKTKDG 653 >UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytogenes 08-5578 RepID=D2P3C5_LISMO Length = 714 Score = 474 bits (1221), Expect = e-132, Method: Composition-based stats. Identities = 181/615 (29%), Positives = 302/615 (49%), Gaps = 26/615 (4%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIEC-----GNGQVVTWCIGHLLEQAQPDAYDS 56 + +AEKP+ A A+ + +K GF E + +T +GHL++ P YD Sbjct: 3 IVILAEKPNQALTYAEAM-HHFKKHRGFYEVQDELFADQTFITHGLGHLVDLFMPGQYDP 61 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + +W++ +LPI PE + +PS +Q ++K+ L EA+ I+ A D DREG+L+ E+L Sbjct: 62 KLKKWDMTNLPIFPETIRYYVKPSNQEQFQIVKKLLSEATTIIIATDCDREGELIAREIL 121 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + +L+ E + +QR IN L +A+ L V A R ++DWL G+N Sbjct: 122 NQTKLSFEG-KNIQRLWINSLEKEAIREGFQSLWHAGHTYFKYVEAQTRQKSDWLIGMNF 180 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 T Y++L + G +GRVQTP L +V +R++EIENF + FE+ + +++ Sbjct: 181 TPLYSLLLQEYGSFSQYPIGRVQTPTLMMVYKREKEIENFKPRKMFELF-YENKMEEQKI 239 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A + + ++ L R + RI A V + +K E ++PL FSLS Sbjct: 240 LAKIKTHPLFDTKEEVYAFLKERNM------RIGPTEATVLNMVEKEEKHASPLLFSLSN 293 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQI K+F S + L QKLYE K ++YPR+DC ++ ++ F+ + A Sbjct: 294 LQILMNKKFKYSPKETLQGVQKLYE-KKWLSYPRTDCTFITQKEFSYLKMKLQEYKAFAH 352 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQYLM 412 + P ++PD R D+ +V+ HHAIIPT + LT E ++Y + + Sbjct: 353 IEVYTPNLEPDF--RYVDNHEVNEHHAIIPTRIIPSAAEFSKLTTLEKQIYTWVLHVTIA 410 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P + ++ ++L I + F AK R + GWR ++ + E+ L GD Sbjct: 411 MFAPPMLIKEIAMDLRIGELLFEAKERTPVDMGWRKIILGNNQKEKISRQSLSNFHIGDT 470 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +E+ +PP FT+ L+ AM + + K++ G+GTEATRA ++ Sbjct: 471 IH-GFLGGIEKDKKPPSPFTEGALIHAMKNAGK--KAGQSKEMGLKVMGIGTEATRADVL 527 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQCRYQD 590 E L + +L ++ TD GK L + + + DMTA E+ L I E ++ Sbjct: 528 EKLKNQDYLKLTKNKLYVTDKGKELGRVIENDPLLSNIDMTASLETALHSIGEGITTQEE 587 Query: 591 FMQPLVGTLYQLIDQ 605 F++ L G + + I + Sbjct: 588 FLKNLKGMIQKYIQK 602 >UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus group RepID=C2UN45_BACCE Length = 756 Score = 472 bits (1214), Expect = e-131, Method: Composition-based stats. Identities = 167/639 (26%), Positives = 293/639 (45%), Gaps = 51/639 (7%) Query: 6 AEKPSLARAIADVLPKPHRKGDGFIE------CGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 AEKP +A+ I PK ++K D + E +G V +C+GHLL + Sbjct: 2 AEKPDVAKKIVAAFPK-YKKHDLYYEIMPCNEFPDGAYVAYCMGHLLTFDEEKM--GTNT 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLD 117 W+L+ LPI+P+ + +P K + IK+ ++ + ++ D REG + E++ Sbjct: 59 PWSLSGLPIMPKSYIYKPIKGREKHVRTIKKLANDPKVTMFINCCDSAREGMKIFTEIIK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y+ + + I+ L P ++++ + L L SA ARA AD+L GIN++ Sbjct: 119 YV---TNRNLPTKCLWISSLTPASIKKGMQELVPYKSKENLYHSAYARAIADFLVGINLS 175 Query: 178 RAYTILGR-------------NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 R+ ++ + N + V S+GR Q+P L LV R ++IE V + F+ + Sbjct: 176 RSVSLRMQSEFASRNAENGDLNGLKREVFSIGRCQSPTLRLVYDRIKQIEAHVPEPFWTL 235 Query: 225 KAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 E +T W ++++ R E + R+ +PAI+ +R+ Sbjct: 236 SGIFEIDGKE-YTGRW--------FKEDNNRFDSEEEIEDLSIRLVEEPAIIKEIKKERK 286 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 + P F L+ LQ A K F + + L + LY L++YPR+D Y+ Sbjct: 287 AFKPPQFFDLTRLQSTANKLFKMDPKETLHHAESLY-LAGLLSYPRADNPYITAAEAPIL 345 Query: 345 HAVMNAIS--VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAK 401 V+ + LP P+ D+ +R ++KKV HH II L E Sbjct: 346 STVLEKLKYTESYSKYLPAPIRSTDLSSRYINEKKVSDHHGIIVLDVPKDFSKLNPGEKA 405 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEEND 460 +Y+L+ ++ + DA++ I + + F+ K + GW+ L ++ EE D Sbjct: 406 IYDLVVKRVIAAHHEDALYDFTSIITVVDETETFLTKGKQEVSLGWKMLYQKEQVSEEKD 465 Query: 461 GTP--------LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDL 512 LP V +GD E+ + T+ P + T TL+ M +++K++ Sbjct: 466 DQEEENEEVAQLPDVKEGDTGTIVDTEISKGMTKAPPYLTPGTLVELMENCGSLMEEKEM 525 Query: 513 KKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDM 570 +KIL+ T G+GT ATR GII L+ RG+L K + + G+ L +L + + P++ Sbjct: 526 QKILKKTSGIGTVATRDGIIHTLYDRGYLVNKNNKVLLLEKGRMLMDALGDKMIVCSPEL 585 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT 609 TA WE+VL IS+ + Y+ F+ + +L++ ++ Sbjct: 586 TAKWENVLEAISDGRIDYKQFIGKAEKLVVKLLNDIEQI 624 >UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_SYMTH Length = 735 Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats. Identities = 145/694 (20%), Positives = 271/694 (39%), Gaps = 105/694 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + V +GH+ + + S + Sbjct: 5 LIIVESPAKAKTIEKFLGRK-------------YAVKASMGHVRDLPKSQLGVSVENDFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P+ ++ + + L ++ +A + A DPDREG+ + + L+L Sbjct: 52 -------PKYITIRGKGDI---LKELRESARKADRVYLATDPDREGEAISWHLAQVLKLP 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ R +++ A++RAI + R + + AR D L G ++ + Sbjct: 102 LDEPL---RIEFHEITKDAIQRAIKQPRPID--LNRVEAQQARRVLDRLVGYKLS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW-- 240 L R + LS GRVQ+ + L+V R+ EI+ F ++++ + A + T + F+A + Sbjct: 154 LWRKV--RRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWG 211 Query: 241 QPSEACEPYQDEEGRLL------HRPLAEHVVNRISGQPA----------------IVTS 278 + + ++ R + R A + G P V S Sbjct: 212 MGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRS 271 Query: 279 YNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET--------HKLITYPR 330 + + + PF+ S+LQ EA+++ G S + + + Q+LYE L+TY R Sbjct: 272 VKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIR 331 Query: 331 SDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-- 388 +D + +E + + D +P+ +PD R + AH AI PT Sbjct: 332 TDSTRIADEAARAAAEFIE--RQYGKDYVPERRREPDRRA-----GEQGAHEAIRPTDVT 384 Query: 389 ---RSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAG 445 S LT ++ ++Y LI ++L AV +EL + F A + + G Sbjct: 385 RTPESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPG 444 Query: 446 WRTLLGSKERDE---ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + + E D+ E LP +A+G ++ + E + TQPP +++A L+ A+ Sbjct: 445 FMKVYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALE- 503 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 G+G +T A II + RG++ K+ + + T+ G + L Sbjct: 504 ----------------ERGIGRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILK 547 Query: 563 EMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV-----RQF 614 E + TAH E L ++ E + +++ ++ G + + QA+ + Sbjct: 548 EYFPDIIDVEFTAHLEGKLDEVEEGRVNWRELIRRFYGPFEETLKQAEEKVGGFELEDEV 607 Query: 615 RGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 + G K K A P + Sbjct: 608 SDVPCEKCGRLMVVKHGRFGKFLACPGFPECKST 641 >UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP1_BACHD Length = 690 Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats. Identities = 129/651 (19%), Positives = 249/651 (38%), Gaps = 86/651 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K V +GH+ + + ++ Sbjct: 5 LVIVESPAKAKTIGKYLGKK-------------YTVKASMGHVRDLPKSQMGVDIEDEYS 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P ++ + V L +K + + A DPDREG+ + + L + Sbjct: 52 -------PRYITIRGKGPV---LKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDID 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R + N++ QA++ A R + + L + AR D L G N++ + Sbjct: 102 ETSEC---RVVFNEITKQAIKDAFKSPRPIN--MDLVDAQQARRVLDRLVGYNIS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ + +++ R++EI+ F ++++ ++ E F A + Sbjct: 154 LWKKV--KKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALDG-EPFEAKFYG 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ L +V+ ++ G V S K + PF+ S+LQ EAA Sbjct: 211 TNG------KKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + A + Sbjct: 265 RKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAET-------KEY 317 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQ 409 + + D K DAH AI PT+ +S L+ ++ ++Y LI + Sbjct: 318 IESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWER 377 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVA 468 + A+ ++L F A + G+ + + ++ + LP + Sbjct: 378 LVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQ 437 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G + E+ E + TQPP +T+A L+ M + +G +T Sbjct: 438 EGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELG-----------------IGRPSTY 480 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A ++ + KRG++ R T+ G+ + + E + TA E L I E + Sbjct: 481 APTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEGK 540 Query: 586 CRYQDFMQPLVGTLYQLI----DQAKRTPVR-QFRGIVAPGSGGSADKKKA 631 ++ + + + ++ K ++ + G + G K Sbjct: 541 QQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMG 591 >UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi RepID=A5CF60_ORITB Length = 788 Score = 470 bits (1209), Expect = e-130, Method: Composition-based stats. Identities = 136/654 (20%), Positives = 264/654 (40%), Gaps = 83/654 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I E P+ A+ I L G+ V GH+ + Sbjct: 1 MKLLIVESPAKAKTINKYL-------------GSDFQVVASYGHVRDLLAKAG------- 40 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP + + P T+ + I ++ I A DPDREG+ + +++ L+ Sbjct: 41 ---SVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIVEVLK 97 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 +R + N++ +A+ A+ + R + + L + AR D+L G +++ Sbjct: 98 EKKIF-ANFKRIIFNEITKKAIGDALQQPRDIN--LNLVNAQQARRSLDYLVGFSLS--- 151 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L R G S GRVQ+ L L+ R+EEI F++++++ + +++ DE TA Sbjct: 152 PLLWRKL--PGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKL 209 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + E+ + ++ A+ +V I Q V K+ +S P PF S+LQ E Sbjct: 210 IEFDGNKL---EKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQE 266 Query: 301 AAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 AA + G +A+ + I QKLY E+ LITY R+D L ++ ++ S Sbjct: 267 AAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFIS--SS 324 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIAR 408 + LP+ + +++ + +AH AI P T + ++ K+Y LI + Sbjct: 325 FGNNYLPRQIR--AFKSKVKN--AQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQ 380 Query: 409 QYLMQFCPDAVFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 + + + + I A +A G+ + + DEE + LP Sbjct: 381 RTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGFYKVYK-EINDEEENKKLLPN 439 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +++ + + + + T+PP +++ATL+ + + +G + Sbjct: 440 LSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLG-----------------IGRPS 482 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISE 583 T A II +L +R ++ + + G+ + L + D TA E L I++ Sbjct: 483 TYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAK 542 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ--------FRGIVAPGSGGSADKK 629 +Q+ ++ + + ++ + + P G D K Sbjct: 543 GMIGWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPVQNGETDHK 596 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 141/664 (21%), Positives = 257/664 (38%), Gaps = 97/664 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K G V +GH+ + + ++ Sbjct: 5 LVIVESPAKAKTIQKYLGK-------------GYEVEASLGHIKDLPKKGLGVDIENNFD 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + P K + +K+ +A I A DPDREG+ + + + L Sbjct: 52 T----------EYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIAAHLAEELGDG 101 Query: 123 PEKRQ------QVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 K++ R N++ +AV+ A + R L + R D L G + Sbjct: 102 DGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDR--NLVDAQQTRRILDRLVGFQV 159 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 + R LS GRVQT L L+V R+ EI+ FV+K+++ + AH+ F Sbjct: 160 SPLLWDKVRRG-----LSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKPPDF 214 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A + + E+ + + ++ +V+++ V S +++ +A PF+ S Sbjct: 215 DARFTGIDG------EKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSK 268 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVM 348 Q +A+++ G+S + + I Q LYE T LITY R+D + E ++ Sbjct: 269 FQQDASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELI 328 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVY 403 + P LP+ P++ + D AH AI P T L ++E KVY Sbjct: 329 GT--SYGPQFLPE---SPNVYKQKKD--AQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVY 381 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIA---KGKFVAKARFLAEAGWRTLLGSKE--RDEE 458 LI ++++ AVF + +++D F L G+ + + +DEE Sbjct: 382 KLIWQRFVASQMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEE 441 Query: 459 NDGT--PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 +D LP + +G L + + + T+PP + +A+L+ + Sbjct: 442 DDALKHKLPPLVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQG------------ 489 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTK---KGRYIHSTDAGKALFHSLPEMATRP---DM 570 +G +T A I+ + RG++ K +G T+ G + L Sbjct: 490 -----IGRPSTYAAILSTIQDRGYVQKTPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKF 544 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGS 625 T+ E L ++ + Q ++ D ++ +D A++ + + G Sbjct: 545 TSRMEEELDEVEDGQKKWTDTLKEFYDKFETNLDYAQKHMENIKRMEKPTDEKCERCGSP 604 Query: 626 ADKK 629 K Sbjct: 605 LVIK 608 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 162/680 (23%), Positives = 284/680 (41%), Gaps = 75/680 (11%) Query: 1 MRLFIAEKPSLARAIADVLP--KPHRK---GDGFIEC---GNGQVVTWCIGHLLEQAQPD 52 M L IAEKP++AR IA L +P +K G + E G +V +GHL A Sbjct: 1 MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKR 60 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 + + D+ VP + + + + + E + A D D EG+++ Sbjct: 61 DVFG----YPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIG 116 Query: 113 DEVLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 L Y + P +R + L + + A L F + + +AR DW Sbjct: 117 YTALKYACGVDPRV---AKRMKFSALTKRDLLNAWRNLEPTINF-GMANAGIARHILDWY 172 Query: 172 YGINMTRAYTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 +G+N++RA T + A G VLS GRVQ P L +V R+ EI++FV + ++ +K Sbjct: 173 WGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFE- 231 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 ++FTA + E+ ++ + +V + V++ KR+ + P Sbjct: 232 KNGQKFTANY-----------EKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPH 280 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 PF L LQ EA FG S + LDI Q LYE +YPR++ + LP + R + N Sbjct: 281 PFDLGTLQREAYSAFGFSPKKTLDIAQSLYE-KGFSSYPRTESQKLPR-NINFRMIIQNL 338 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQ 409 + ++ K+ AH AI PT +LT++E K+Y++I R+ Sbjct: 339 AKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRR 398 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 +L F A+ + + KF + GW ++ G + EE LP Sbjct: 399 FLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEE---VTLPEFFI 455 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + + + +++T+PP ++ A ++ M + LGT+ATRA Sbjct: 456 GERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLG-----------------LGTKATRA 498 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQC 586 I+E L++RG++ K + I T G + +L + ++T +E + I E + Sbjct: 499 QILETLYQRGYIEGK-KSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRL 557 Query: 587 RYQDFMQPLVGTLYQLIDQAKRT----------------PVRQFRGIVAPGSGGSADKK- 629 ++ ++ L +++++ K+ V+ P GG K Sbjct: 558 TKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKY 617 Query: 630 -KAAPRKRSAKKSPPADEVG 648 K ++ + P +V Sbjct: 618 NKKTGKRFVGCSNWPKCDVT 637 >UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_CLOPH Length = 721 Score = 469 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 181/716 (25%), Positives = 313/716 (43%), Gaps = 95/716 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+I+EKPS+A+ A L RK DG++E +VTWC+GHL+ + P++YD +W+ Sbjct: 11 LYISEKPSVAQEFAKALKSNFRKSDGYMES-EDSIVTWCVGHLVTMSYPESYDPALKKWS 69 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +P +P++++ + PSV+KQ V+K L+ + +I D REG+ + V + Sbjct: 70 LQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAK 129 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + K ++ R I+ + + R I + S++ L SA RA+ D+L GIN +R Sbjct: 130 VPKNKEKR--RVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVL 187 Query: 181 TIL-------GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 ++ ++VGRV T VLG+VVRR+ EI FV F+ V + T Sbjct: 188 SLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDR 247 Query: 234 ---ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP----------------- 273 F A+ P +E + AE ++ ++G Sbjct: 248 TFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLA 307 Query: 274 ------------AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE 321 A + S K+E+++ PL F+L+ LQ E +K F +S L Q+LYE Sbjct: 308 KLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYE 367 Query: 322 THKLITYPRSDCRYLPEEHFAGRHAVMNAI------SVHAPDLLPQPVVDPDIRNRCWDD 375 KL+TYPR+D R L + + + A ++L + R +D Sbjct: 368 -KKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVND 426 Query: 376 KKVDAHHAIIPTARS--SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK 433 K++ H+AIIPT + + +L+ +VY I +++L F P AV++K I I Sbjct: 427 KQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTES 486 Query: 434 FVAKARFLAEAGWRTLLGS-------------------------------KERDEENDGT 462 F + R L E G+ + G +E +EE D Sbjct: 487 FFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYD 546 Query: 463 P-----LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 + + KG +L + E +T PP+ + +L+ AM + + D++L+ ++ Sbjct: 547 ATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIK 606 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLP---EMATRPDMTA 572 + G+GT ATRA I+ L K +L+ + + G+ ++ + ++TA Sbjct: 607 GS-GIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTA 665 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADK 628 WE LT +S+ +++ L G + ++ + K + K Sbjct: 666 SWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK 721 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 469 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 150/653 (22%), Positives = 259/653 (39%), Gaps = 87/653 (13%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L I E P+ AR ++ L G+ +V +GH+ + + + Sbjct: 1 MKHLIIVESPAKARTLSKFL-------------GSQFLVKASMGHVRDLPKSELGVDLEN 47 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + + K + +K ++ +A ++ A DPDREG+ + + L Sbjct: 48 GFTP----------KYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLL 97 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + PE R +++ AV ++ R + + AR D L G ++ Sbjct: 98 GIPPETPC---RVEFHEITKNAVLNSLKSPRPID--LNRVNAQQARRVLDRLVGYGLS-- 150 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +L R + LS GRVQ+ L LVV R+EEIE F ++++++ ++TP +ER A Sbjct: 151 -PLLWRKV--KRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLAR 207 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ ++ E V + + V + S++ PLPF+ S + Sbjct: 208 LAR------FKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQ 261 Query: 300 EAAKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EA +R G+ + + + Q+LYE LITY R+D + EE A + Sbjct: 262 EANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIK-- 319 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLI 406 + V D + R + DAH AI PT LT ++ K+Y LI Sbjct: 320 ----EHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLI 375 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 ++L A + E+++ F A R L G+ L +E + LP Sbjct: 376 WERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEE---EEEGKLPP 432 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G+ L ++ + T PP +T+ TL+ A+ G+G + Sbjct: 433 LREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALE-----------------EKGVGRPS 475 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISE 583 T A IE + KRG++ + +Y+H T G+ + L E TA E L + E Sbjct: 476 TYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEE 535 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-----FRGIVAPGSGGSADKKKA 631 Q + D ++ + Q + +A + F I P G KK Sbjct: 536 GQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTG 588 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 146/672 (21%), Positives = 260/672 (38%), Gaps = 90/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A++I +L G V GH+ + + + A + Sbjct: 6 LIVVESPAKAKSIQKMLGA-------------GYEVRASKGHIADLPEHELGVDTQADFA 52 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q + + +KR ++ A DPDREG+ + V L L Sbjct: 53 P----------QYTVKKDKQPIVEELKRAAR-GKRVLIATDPDREGEAIGWHVARLLGLN 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P+ R +++ P+ V A+ + R + L + AR D L G ++ ++ Sbjct: 102 PQTPL---RVEFHEITPKVVRAAVQKPRPIDQ--SLVDAQQARRVLDRLVGYQLSPVLSM 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R + LS GRVQ+ L L+V R++EIE FV ++ + ++ + ++F A+ Sbjct: 157 EFR----RRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEG-QQFKAMLYS 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESAPLPFSLSALQIEA 301 + ++ + A+ + + S + +AP PF S LQ A Sbjct: 212 LGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAA 271 Query: 302 AKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + R G +A + + QKLYE T LITY R+D + +E A A + Sbjct: 272 SSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIP--RHF 329 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P LP+ P+ DAH AI PT+ + L++ E ++Y LI ++ Sbjct: 330 GPAYLPE---KPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQR 386 Query: 410 YLMQFCPDAVFRKCVIELDIAKGK------FVAKARFLAEAGWRTLLGSKERDEENDGTP 463 ++ AVF + + + A G F A L G+ + G +E DE + Sbjct: 387 FVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAEN--R 444 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + + + T+PP +TDA+L+ + + +G Sbjct: 445 LPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMG-----------------IG 487 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA----LFHSLPEMATRPDMTAHWESVLT 579 +T A I+ L +RG+L + G+ + T G+ L S P++ D TA ES L Sbjct: 488 RPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVA-YDFTAQLESRLD 546 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 +I E + + ++ + + + + P G + K + + Sbjct: 547 EIEEGKAAWPKVVREFYEPFLKDFAKVPQK--------LCPKCGRPLELKVSRFGQFLGC 598 Query: 640 KSPPADEVGSGA 651 P + Sbjct: 599 TGYPECKHTERL 610 >UniRef50_C4GAJ6 DNA topoisomerase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GAJ6_9FIRM Length = 770 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 190/774 (24%), Positives = 322/774 (41%), Gaps = 134/774 (17%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 LFIAEKPS+AR A L + + DG++E G +VTWC+GHL+ + P+AYD +W Sbjct: 5 LFIAEKPSVAREFASALGENTSRRDGYLE-GEHLIVTWCLGHLITMSYPEAYDPGLKKWR 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP +PE ++ + P+ +Q ++ L+ + I D REG+ + V Sbjct: 64 MDTLPFIPETFRYEVLPNSARQYQIVASLLNRSDVDTIYVCTDSGREGEYIYRLVAQEAG 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + + +R I+ + + R I R S++ L SA RA+ D+L GIN +R Sbjct: 124 VQDKVQ---KRVWIDSQTREEILRGIKEARDESDYDHLAASAYLRAKEDYLMGINFSRIL 180 Query: 181 TIL-------GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV---- 229 ++ GY +SVGRV + VLG+VVRR+ EI +FV F+ V + Sbjct: 181 SLKYGSAIANMLKEGYSS-ISVGRVMSCVLGMVVRREREIRDFVKTPFYRVLGDVNLLPE 239 Query: 230 --------------TPADERFTAIWQPSEACEPYQD------------------------ 251 + A E P D Sbjct: 240 SPGQSSVSLGAEQTGQGSDSLGAEQTGQELGSPGVDRTGQGRGDLRQAILKGLEWRAVPG 299 Query: 252 ----------EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKR-----------------E 284 +E R A ++ ++ P S + E Sbjct: 300 SRYENSPLLYKENGFKERTDALGLIEELNQLPKKSLSLEKEEDYPCSLKGKIQKIGRKKE 359 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 ++ PL ++L+ +Q + ++ F +S L I Q+LYE KL+TYPR+D R L Sbjct: 360 KKNPPLLYNLAEIQNDCSRFFKISPDETLAIIQELYE-KKLVTYPRTDARVLSTAVAKEI 418 Query: 345 HAVMNAISV------HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR--SSAINLT 396 + ++ ++L Q + + R DDKK+ H+A+IPT + + + Sbjct: 419 DKNIRGLAGIPGVRTFVREILDQGLYKGIAKTRYTDDKKITDHYALIPTGQGLGALGRMP 478 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS---- 452 A VY +I R++L F AV+ K + + F A ++L E G+ ++ Sbjct: 479 RRAAMVYEIIVRRFLAIFYDPAVYEKLNLTVCAWGESFFASDKYLVEEGYLKVMHYSFQK 538 Query: 453 ------KERDEENDGTP------------------------LPVVAKGDELLCEKGEVVE 482 ++ +EE +G LP + KGD + V E Sbjct: 539 KEGGSGRKEEEEQEGNAIGQDETKKDDAEDSRENQALLARLLPKLKKGDPVCFLAFCVKE 598 Query: 483 RQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLT 542 +T PP+ + +L+ AM + ++D++L+ +++ G+GT ATRA I+ L + +L+ Sbjct: 599 GETSPPKRYNSGSLILAMENAGQLIEDEELRAQIKS-QGIGTSATRAEILNKLIRISYLS 657 Query: 543 KKGRY--IHSTDAGKALFH----SLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + I T G+ +F S+P+M ++TA WE LT ++E ++M+ L Sbjct: 658 LNKKTQIISPTLRGELVFDVIAASMPQML-NAELTASWEKGLTYVAEGTISEDEYMKKLD 716 Query: 597 GTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 + +D+ K + G S K K + R+ KK G Sbjct: 717 AFIRLRVDRVKAMQNQSLLGSQFAAVAASYPKPKGNVKTRAVKKKAVRKSGKEG 770 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 466 bits (1200), Expect = e-129, Method: Composition-based stats. Identities = 143/672 (21%), Positives = 271/672 (40%), Gaps = 88/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K ++ V +GH+ + + + Sbjct: 5 LVIVESPAKAKTIEKYLGKKYK-------------VIASMGHVRDLPRSQMGVDVEDNYE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P+ ++ + V K L K++ +A + A DPDREG+ + + L+L Sbjct: 52 -------PKYITIRGKGPVVKDL---KKYAKKAKNVFLASDPDREGEAIAWHLSKILELD 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K R + N++ AV+ + R + L + AR D L G N++ + Sbjct: 102 DSKEN---RVVFNEITKDAVKESFKHPRGIE--MDLVDAQQARRILDRLVGYNIS---PV 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ L LV+ R+ EI NF ++++ ++ +FTA + Sbjct: 154 LWKKV--KKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKS-KFTAKFLH 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+++ +L + E V + G +T+ N K ++ + PF+ S LQ EAA Sbjct: 211 ------YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + + + Sbjct: 265 RKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIED--KY 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-----SSAINLTENEAKVYNLIARQ 409 D L DAH AI PT+ LT ++ ++Y LI + Sbjct: 323 GKDYLSNRTAKG-------KQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWER 375 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-GTPLPVVA 468 ++ A+ +++ KF A + + G+ TL + D++N+ LP ++ Sbjct: 376 FVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLS 435 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGDE+ + E + TQPP +T+A L+ + + +G +T Sbjct: 436 KGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEEL-----------------KIGRPSTY 478 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A I+ + KR ++ + + T+ G+ ++ + + + T + E++L +I+E Sbjct: 479 APTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAEGD 538 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + G+ +++A+ + + G G K K A Sbjct: 539 IGWRKVIDNFYGSFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACS 598 Query: 641 SPPADEVGSGAI 652 + P + Sbjct: 599 NFPDCRNTKAIV 610 >UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1ABE5_GEMAT Length = 816 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 139/669 (20%), Positives = 249/669 (37%), Gaps = 102/669 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + G V +GH+ + Sbjct: 52 LVIVESPAKAKTIGKYLGR-------------GYTVKATVGHVRDL-------PAKKLGI 91 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D PE ++ + + L +K+ A EI A DPDREG+ + V Y Sbjct: 92 DIDHGFAPEYVTIEGKEDI---LTDLKKVAKGAREIFIATDPDREGEAIGWHVEQYFTQP 148 Query: 123 PEK--RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++R + +++ AV +++ + + AR D L G + Sbjct: 149 KRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKK--VEAQQARRVLDRLVGYKAS--- 203 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L + + LS GRVQT L L+V R+ EI F +++ + A + + FTA Sbjct: 204 PVLWKTV--KKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADL-QKGQQPFTAKL 260 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQI 299 + +P + + AE ++ ++G + +VT + ++ PF+ S LQ Sbjct: 261 HQLDGKKPE------IGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQ 314 Query: 300 EAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EAAK+ G ++ + + Q LYE LITY R+D + E+ + A Sbjct: 315 EAAKKLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRA- 373 Query: 352 SVHAPDLL-PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 D L P P + P + DAH + PT S LT ++ K+Y L Sbjct: 374 -QFGDDFLAPAPQLYPSGKA-----NAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQL 427 Query: 406 IARQYLMQFCPDAVFRKCVIELDIA--------KGKFVAKARFLAEAGWRTLLGSKERDE 457 I ++++ AVF ++ +I F A + G+ L + Sbjct: 428 IWQRFMASQMAPAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEG 487 Query: 458 E----NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 + D LPV+ + + + + T+PP F++A+L+ + Sbjct: 488 DAKALEDEQALPVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAG--------- 538 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKAL----FHSLPEMATRPD 569 +G +T A II +L +R +++ + R T G+ + P++ Sbjct: 539 --------IGRPSTYASIISVLVERRYVSLEQRRFFPTSLGETVEKVMVKKFPDVF-NVG 589 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA-------KRTPVRQFRGIVAPGS 622 TA E L +I+E + + + + ++ + + P Sbjct: 590 FTAQMEEELDKIAEGEIDWVRALGDFWTPFQRTLNDNDLDALIGEAYDLSALETERCPDC 649 Query: 623 GGSADKKKA 631 GG K Sbjct: 650 GGKLVAKGG 658 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 144/664 (21%), Positives = 260/664 (39%), Gaps = 84/664 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I +L K + V GH+ + + + + Sbjct: 5 KLIIVESPAKAKTIEKILGKDFK-------------VLASYGHIRDLPEKELGVDIENGF 51 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + PS K ++ IK + ++ A DPDREG+ + +++ L+L Sbjct: 52 KP----------KYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLVETLKL 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + R +++ P+A++ AI R + + AR D L G ++ Sbjct: 102 ---PKDKFTRIEFHEITPRAIQEAIRNPRDID--LDKVEAQQARRILDRLVGYELSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L L+ R+EEIE FV ++++ + + Sbjct: 157 EKVRRG-----LSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKDKIIYG---- 207 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 Y++EE + + A+ ++ ++ + K E ++ PLPF S LQ EA Sbjct: 208 ---KLVFYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEA 264 Query: 302 AKRFGLSAQNVLDICQKLYETH-------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++R G + I Q LYE LITY R+D + E + SV Sbjct: 265 SRRLGFPVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIE--SVF 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQ 409 + + + R DAH AI PT+ LTE++ K+Y LI + Sbjct: 323 GKEYVGKE------RKERKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWER 376 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 +L +A++ I++ FV+K R L AG+ +L KE +EE + + + Sbjct: 377 FLASQMANALYDVIEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQE 436 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G ++ + TQPP +T+ATL+ + +G +T A Sbjct: 437 GSDIDLINLTPKQFFTQPPPRYTEATLVRTLEKYG-----------------IGRPSTYA 479 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQC 586 IIE L +R ++ + + T GK + L + TA E L +I + Sbjct: 480 TIIETLKERKYVEVSKKELVPTTLGKVVNEFLTKQFPHLIDVKFTAKMEEDLDKIESGEV 539 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 + + ++ + + +++ + + + P G ++ K A + Sbjct: 540 KAIEVLEKFYPSFKEELERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAY 599 Query: 643 PADE 646 P + Sbjct: 600 PECK 603 >UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyticus ATCC 51172 RepID=C2BD67_9FIRM Length = 683 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 177/657 (26%), Positives = 293/657 (44%), Gaps = 52/657 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A++IA+VL +++ DG+IE G +VTW GHL+ P++Y+ Sbjct: 5 MKLIIAEKPSVAKSIANVLG-CNQQQDGYIE-GRSCIVTWTGGHLVTLDDPESYNPSCNH 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEVLDY 118 WN ADLPI+P ++ + S + Q V+K +++ +V A D REG+L+ V D Sbjct: 63 WNKADLPILPRPFKTKLISSKSHQYKVVKNLINDKRIESVVCATDAGREGELIFRLVYDK 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ R I + A+ ++ + + L SA AR ADWL GIN+TR Sbjct: 123 IG----TKKTFTRMWIQSMEDPALLDEFNKAKDGHAYDNLSESAKARQEADWLVGINLTR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +I ++GRVQTP L L+ R EE ENF + + ++A I Sbjct: 179 LVSI-----ENNKKFTIGRVQTPTLNLINARCEEKENFKPQKYNTIQADISLDG------ 227 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E R+ + + + + + ++ AP + L+ LQ Sbjct: 228 --------KVITFETERIETQESNCKMSSM--SSELEIEEVISEEKTTKAPKLYDLTNLQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A K+FGLSA+ LDI Q LYE K I+YPR+D Y+ + +V I H Sbjct: 278 RAANKKFGLSAKQTLDIAQSLYEA-KYISYPRTDSEYITSDM---VESVRQLIGSHVDSD 333 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLMQ 413 + V + ++KKV H A++PT + NL +N +Y LI Q L Sbjct: 334 MFDNV------EKIANNKKVSDHTALLPTIYSIDKKDEINNLDKNHINIYTLIYMQLLKA 387 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 + + + I+ + + G++ L + + L + +G Sbjct: 388 VSKNYRYMQTKIKAISGDIDLYTVGKVDIDQGFKKL--ESKDNAAKSEKDLSGLEEGMSY 445 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 ++++ T+PP ++ D +LL AM + +K L+ GLGT ATRA IIE Sbjct: 446 PITDTRLMDKTTKPPAYYNDDSLLKAMKTAGSGLYEKGLE---IERTGLGTTATRADIIE 502 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L K G++ + + I T+ GK L PE ++T +WE+ L +ISE + F+ Sbjct: 503 GLIKNGYIERSKKDIVITELGKQLLSVAPEKLKEVELTVNWENELAKISEGEKDKNSFIL 562 Query: 594 PLVGTLYQLIDQA---KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 + L +++ + V + P G+ + ++K Sbjct: 563 KIENYLKEIVKSYEGDESMKVEETIIGTCPYCQGNVYINDRSINCENSKHGKNKGNC 619 >UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteobacterium BAL199 RepID=A8TWU8_9PROT Length = 894 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 196/675 (29%), Positives = 308/675 (45%), Gaps = 56/675 (8%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 I EK S A+ + + G + GHLL+ +P+ + RW+ Sbjct: 6 VITEKTSQAKDVRAAVG------------GRYGTILAAEGHLLDLQEPEDVVPEWKRWSS 53 Query: 64 ADL-PIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L P + + +L I+ LH A + A D DREGQL+ E+L++ Sbjct: 54 VLLRPEGLYGTRPAVGGNKAAKLKAIREALHTARRVWLATDCDREGQLIGQEILEHCGF- 112 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R +V R + + Q + + DR R N+++ L +A+AR +AD +Y +++TR T+ Sbjct: 113 ---RGEVLRVMFTAQDTQTIRDSFDRARPNADYAGLYAAAVARRQADQIYNLSLTRTATV 169 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 G + V+ VGRV+TP L +V RR+ EI FV +FE+ A A + FT P Sbjct: 170 TLGK-GARSVVGVGRVKTPTLAIVCRRELEIRQFVPVAYFEITATATVAAGD-FTMRHAP 227 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E R+L R AE ++N + + + + P L +LQ A Sbjct: 228 ----------EKRILRRADAESILNAARDFEGP-LAVRVEDKRQGPPKLHDLPSLQKLCA 276 Query: 303 KRFGLSAQNVLDICQKLYETH--KLITYPRSDCRYLPEEHFAGRHAVMNAISVH---APD 357 RFG SA L+I Q+LY+ K+ITYPR++ RYLPE ++ + V A Sbjct: 277 SRFGWSAARTLEIAQELYDGQNKKIITYPRAEVRYLPESLIPDVPKIVAGLQVGKSCATI 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVD--AHHAIIPTARSSA------INLTENEAKVYNLIARQ 409 +P P V + + DK ++ +HHA+IP + A L+ +E K+++++AR Sbjct: 337 AVPTPPVIRKGAHGAFHDKGLEGASHHAVIPNVNTVAGLREVWPRLSLDEKKLFDVVARA 396 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVV 467 YL PD +R+ LD+ F A R + GWR + +E D LP + Sbjct: 397 YLAAMMPDFRYRQTTATLDVRGVPFKASGRQPIDLGWRAAFPEWQPADEKSGDAQLLPPI 456 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G+ + +++T+PP + + TL+ AM RFV+D+ L+ LR G+GT AT Sbjct: 457 LDGETARLRDAAIEDKETRPPPRYNEGTLIEAMQNAWRFVEDEALRNRLREAKGIGTPAT 516 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEK 584 RA II L ++ FL +G+ I TD G ALF L P +TA E +L + Sbjct: 517 RAEIIAGLKRQQFLVAQGKAIVPTDTGLALFDVLRQADPALVDPGVTAQLECLLDDVVVG 576 Query: 585 QCRYQDFMQPLVGTLYQLI-DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK--- 640 + D + + G ++I + TP+ + G D+ A KR A+ Sbjct: 577 KQAMIDAIDAVCGVAQRIIGNLTSGTPIVSAALLGGRSVGPRTDRPPTAAMKRFAESIAR 636 Query: 641 ----SPPADEVGSGA 651 +PPA S A Sbjct: 637 RKRIAPPAGYATSSA 651 >UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales RepID=C6BUQ9_DESAD Length = 800 Score = 465 bits (1198), Expect = e-129, Method: Composition-based stats. Identities = 142/662 (21%), Positives = 253/662 (38%), Gaps = 84/662 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ + I+ L + V +GH+ + + + Sbjct: 5 LIVVESPAKVKTISKFLGR-------------NYQVAASVGHVRDLPKNKLGVEENGDFT 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q Q P +N +K+ +A + A DPDREG+ + V ++ Sbjct: 52 P----------QYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIK-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 E + V R N++ +AV+ A++ + +E L S AR D L G ++ I Sbjct: 100 -EVNENVSRIQFNEITARAVKEALEHPQPLNE--QLFDSQQARRILDRLVGYKIS---PI 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + +S GRVQ+ L LVV R++ F+ ++++ KAH+ F A Sbjct: 154 LWKKV--KRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ + AE + + + G P +T +K + P+ S LQ +A Sbjct: 212 VDG------KKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDAN 265 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G SA+ + + Q+LYE T LITY R+D + E V+ + + Sbjct: 266 RRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVI--LDKY 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-----SAINLTENEAKVYNLIARQ 409 + P + DAH AI P S L ++ KVY LI + Sbjct: 324 GDEFYPAKPQVYKSK-----GGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNR 378 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 ++ A F V+ + + +K L G+ + G ++ LP + K Sbjct: 379 FIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEK---LIELPKLEK 435 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L +K E ++ TQPP +++A+L+ + G+G +T A Sbjct: 436 GEVLKVDKIESEQKFTQPPARYSEASLVRELE-----------------EKGIGRPSTYA 478 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQISEKQC 586 II + RG++ + + T+ G + L E TA E L +++ + Sbjct: 479 SIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKI 538 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFR--GIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + M+ V Y ++ A + R GI K + + P Sbjct: 539 EWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPE 598 Query: 645 DE 646 + Sbjct: 599 CK 600 >UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID=TOP1_RICBR Length = 800 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 132/638 (20%), Positives = 254/638 (39%), Gaps = 76/638 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I E P+ A+ I L G+ V GH+ + Sbjct: 1 MKLVIVESPAKAKTINKYL-------------GDEFKVIASFGHIRDLPSKKGSVIPDEN 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 +++ + K ++ I + +A + A DPDREG+ + + + ++ Sbjct: 48 FSM----------KYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIAEVIK 97 Query: 121 LAPEKRQQ--VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + +R N++ +A+ AI+ R L + AR D+L G ++ Sbjct: 98 EKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDN--NLVNAQQARRALDYLVGFTLS- 154 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +L R G S GRVQ+ L L+ R++EIE F +++++++ ++ +E FTA Sbjct: 155 --PLLWRKL--PGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E+ + + A+ + ++ Q V K++ PF S+LQ Sbjct: 211 KLTHINDQKL---EKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EAA++ G SA+ + I QKLY ET LITY R+D L + ++N Sbjct: 268 QEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLIN-- 325 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 + LP P I + +AH AI PT + N L ++ K+Y LI Sbjct: 326 KDYGDKYLP---SSPRIYKSKVKN-AQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELI 381 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKF--VAKARFLAEAGWRTLLGSKERDE-ENDGTP 463 ++ + + + L ++ A +A G+ + DE E + Sbjct: 382 WKRTIACQMENVIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKM 441 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + + L ++ + T+PP +++A+L+ + + +G Sbjct: 442 LPPLKEQEHLKTKEIIPNQHFTEPPPRYSEASLVKKLEELG-----------------IG 484 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQ 580 +T A I+ +L R ++T + + + G+ + L + D TA E+ L + Sbjct: 485 RPSTYATILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDE 544 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 I+ + ++ + I+ + + + V Sbjct: 545 IAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYV 582 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 465 bits (1196), Expect = e-129, Method: Composition-based stats. Identities = 149/655 (22%), Positives = 262/655 (40%), Gaps = 81/655 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I L K V GH+ + + + Sbjct: 4 HLLIVESPAKAKTINKYLGK-------------DFTVLASYGHVRDLVPKEGAVDPENGF 50 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ- 120 + + K + I + A I A DPDREG+ + + + L+ Sbjct: 51 AM----------RYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKE 100 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 K + +QR + ++ P+A++ AI + R + L + AR D+L G N++ Sbjct: 101 RGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIAS--DLVDAQQARRALDYLVGFNLS--- 155 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L R Q LS GRVQ+P L ++V R+EEIE F+ ++++ + A PA F+A Sbjct: 156 PVLWRKV--QRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECTHPAQH-FSAKL 212 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + Q A+ + + + +T +K PF S LQ E Sbjct: 213 IKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAPPFITSTLQQE 272 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A+++ G + + + I QKLYE + LITY R+D L + + ++ Sbjct: 273 ASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDII--AR 330 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIA 407 + + LP +++ +AH A+ PT+ A L+ E ++Y L+ Sbjct: 331 DYGTNALPDKPNVYTTKSK----NAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVW 386 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLLGS----KERDEENDGT 462 ++ + A+ ++L F A + G+ + K +++++G Sbjct: 387 KRTVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGR 446 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LPV+ G+ + E+ + TQPP +T+A L+ A+ + Sbjct: 447 KLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYG-----------------I 489 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLT 579 G +T A II+ L R ++ +GR TD G+A+ L T D TAH E L Sbjct: 490 GRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELD 549 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVA-----PGSGGSADKK 629 IS + + M+ +L++ K + + G V P SG + Sbjct: 550 AISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSAR 604 >UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C6WSV7_METML Length = 864 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 146/654 (22%), Positives = 262/654 (40%), Gaps = 81/654 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E PS A+ + L G+ V GH+ + + ++ Sbjct: 3 KLLIVESPSKAKTLKKYL-------------GSDFEVLASYGHVRDLIPKNGAVDTENQF 49 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + +K ++ I + + A I A DPDREG+ + + + L+ Sbjct: 50 AM----------KYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAISWHIAEILKS 99 Query: 122 APEKRQQVQ-RCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++ R + +++ AVE AI R S +P+ + AR D+L G N++ Sbjct: 100 KKLLKNKLMKRVVFHEITKGAVEHAIAEPRDIS--MPMVNAQQARRALDYLVGFNLS--- 154 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L + + LS GRVQ+P L L+V R+ EIE F +++++ + + F A Sbjct: 155 PLLWKKI--RRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHG-FKAKL 211 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRI---SGQPAIVTSYNDKRESESAPLPFSLSAL 297 + E+ +++ +V ++ S V+ K+ S S PF+ S L Sbjct: 212 VQLNNQKV---EQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTL 268 Query: 298 QIEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q EA ++ G + + + Q+LYE T LITY R+D L E + Sbjct: 269 QQEAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVK- 327 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 + LP+ V +++ +AH AI PT S L + + K+Y + Sbjct: 328 -KNFDTEYLPKSPVMYKTKSK----SAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEM 382 Query: 406 IARQYLMQFCPDAVFRKCVIELDIA--KGKFVAKARFLAEAGWRTLL-GSKERDEENDGT 462 I ++ L A F ++L + F A + L G+ + + +EE + Sbjct: 383 IWKRALACQMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAES 442 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + G+ L EK + T+PP +++A+L+ + + Sbjct: 443 KLPNLETGEILTVEKIYGEQHFTEPPPRYSEASLVKVLEEYG-----------------I 485 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLT 579 G +T A II L R ++ + TD G+ + L E T+ D TA+ E+ L Sbjct: 486 GRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALD 545 Query: 580 QISEKQCRYQDFMQPLVGTLYQLI-DQAK-RTPVRQFRGIVAPGSGGSADKKKA 631 ++E + + M Q I ++A P + P G K+ + Sbjct: 546 SVAEGERDWVPLMDEFWQDFNQQIHNKADVERPGNELIDEACPKCGKPLQKQLS 599 >UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms RepID=TOP1_SYNY3 Length = 898 Score = 464 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 143/669 (21%), Positives = 271/669 (40%), Gaps = 82/669 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQ-AQPDAYDSRYAR 60 +L I E P+ AR I + LP+ +R V +GH+ + A + + Y Sbjct: 3 KLVIVESPTKARTIRNYLPQDYR-------------VEASMGHVRDLPASAEEVPAAYKD 49 Query: 61 WNLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + A+L + E S K + ++ L A E++ A D DREG+ + +L Sbjct: 50 KSWANLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLLQ 109 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 LQ + ++R + +++ +A+ A++ R E L + R D L G ++ Sbjct: 110 LLQ----PKVPIKRMVFHEITQEAIRSALENCRDIDE--NLVHAQETRRILDRLVGYTLS 163 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +L + + LS GRVQ+ + L+V+R+ F ++++KA + F Sbjct: 164 ---PLLWKKIAWG--LSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQ-NKNPFQ 217 Query: 238 AIW-------------QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 A D++ +L A + R++G+P V + +K Sbjct: 218 AKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPG 277 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 PF+ S LQ EA ++ G+SA++ + + QKLYE ITY R+D +L ++ Sbjct: 278 VRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYE-EGYITYMRTDSVHLSDQAVTAA 336 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA----RSSAINLTENEA 400 + + + + L +++ +AH AI P + L + E Sbjct: 337 RNCVQQM--YGKEYLSPQPKQYTTKSK----GAQEAHEAIRPAGTEFRIPNQTGLKDREL 390 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--GSKERDE- 457 +Y LI ++ + DA + + L + +F A + + G+ GS + D Sbjct: 391 ALYELIWKRTVACQMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAA 450 Query: 458 -ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 EN LP + GD C + + V +TQPP +T+A+L+ + Sbjct: 451 LENQEVILPPLKVGDRPNCREIDTVGHETQPPARYTEASLVKTLE--------------- 495 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAH 573 ++G+G +T A II + RG++ + + + T A+ L T+ Sbjct: 496 --SEGVGRPSTYASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLESHFPDLVDTGFTSR 553 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAP 633 E L +I+ + ++ ++Q L + V+ + + P + + + A Sbjct: 554 MEQKLDEIAIGKTQWLPYLQGFF-----LGESGLENQVKVRQDQIDPAIAKAIELENLAA 608 Query: 634 RKRSAKKSP 642 + + K P Sbjct: 609 KVKIGKFGP 617 >UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C6P2V7_9PROT Length = 876 Score = 463 bits (1192), Expect = e-128, Method: Composition-based stats. Identities = 154/672 (22%), Positives = 255/672 (37%), Gaps = 80/672 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ + L K V GH+ + + Sbjct: 5 LLIVESPAKAKTLKKYLGKDFE-------------VLASYGHVRDLIPKTGAVDPDDNFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL-QL 121 + + + K ++ I + EA I A DPDREG+ + + + L Sbjct: 52 M----------KYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIAWHISELLKGK 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K + +QR + ++ AV A+ R S +PL + AR D+L G N++ Sbjct: 102 RALKGKTMQRVVFYEITQSAVREAVAHPREIS--IPLVNAQQARRALDYLVGFNLS---P 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 +L R + LS GRVQ+P L L+V R+ EIE F +++++ V F A Sbjct: 157 LLWRKI--RPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLD-SQKNSIPFKAKLY 213 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESESAPLPFSLSALQI 299 + E+ + + + + ++ P V K + S PF+ S LQ Sbjct: 214 QFQGKRM---EQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQ 270 Query: 300 EAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA ++ G+++ + Q LYE T LITY R+D L E A + Sbjct: 271 EAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKD-- 328 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 A D LP V P +++ + +AH AI PT+ + L ++ ++Y +I Sbjct: 329 NFAGDYLP--VKQPVYKSKSKN--AQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIW 384 Query: 408 RQYLMQFCPDAVFRKCVIELDI--AKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPL 464 ++ L A F +++ + F A + L G+ + + EE D L Sbjct: 385 KRTLASQMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKL 444 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + +GD L +K + TQPP F++A+L+ A+ +G Sbjct: 445 PPLVEGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEYG-----------------IGR 487 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQI 581 +T A II L R + T + TD G+ + L E T TA+ E L I Sbjct: 488 PSTYATIISTLQAREYATLDKKRFMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDI 547 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 SE + + + +LI + K P + P G K+ Sbjct: 548 SEGKRDWIPVLNEFWKGFNKLISEKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGC 607 Query: 640 KSPPADEVGSGA 651 P + Sbjct: 608 TGYPECDYTRSL 619 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 463 bits (1191), Expect = e-128, Method: Composition-based stats. Identities = 157/668 (23%), Positives = 270/668 (40%), Gaps = 79/668 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ A++I L K G V GH+ + D A Sbjct: 1 MYVVIVESPAKAKSINKYLGK-------------GYEVYPSYGHVRDLPAKDGSVDPDAD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + W + + K+LN I R + +A +I+ A DPDREG+ + VL+ L+ Sbjct: 48 FAM--------LWDVDVK--SAKRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLK 97 Query: 121 LAPEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + N + AV A+ R V L + LAR D+L G N++ Sbjct: 98 AKKVLKDKPVERVVFNAITKSAVLEAMQHPRQID--VALVDAYLARRALDYLVGFNLS-- 153 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +L R G S GRVQ+ L LV R+ EIE FVA++++ + AH+ T AD FTA Sbjct: 154 -PVLWRKL--PGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ + + + G A + V K PF+ S LQ Sbjct: 211 LVGADGKKITRLDVGT---GAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G + + + Q+LY ET LITY R+D L E +V+ Sbjct: 268 EASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVI--AR 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIA 407 +P+ ++ + +AH AI PT R+ A L ++AK+Y LI Sbjct: 326 QFGDAYVPKAPRKYTVKAK----NAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGS-KERDEENDGT 462 + + A + ++++ G A + + G+ L ++ +++++ Sbjct: 382 TRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESA 441 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP +AK + L E+ E + T+PP FT+ATL+ M + + Sbjct: 442 RLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLT 579 G +T A + +L +R ++ + + +H D G+ + L R D TA E L Sbjct: 485 GRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARYVGYDFTADLEEKLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 ++S + ++ ++ + K + + G K + Sbjct: 545 RVSNHEIDWKQVLRDFWLDFSGALAGTKDLRTTEVLDRLNEILGPHIFPPKEDGS--DPR 602 Query: 640 KSPPADEV 647 P E Sbjct: 603 GCPSCGEG 610 >UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae RepID=A8ZW15_DESOH Length = 758 Score = 462 bits (1190), Expect = e-128, Method: Composition-based stats. Identities = 137/654 (20%), Positives = 247/654 (37%), Gaps = 88/654 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + I E P+ + I GN VT GHL + P Sbjct: 5 VIIVESPTKVKTITKY-------------TGNAYSVTATSGHLRDL-PPHELGIDIDNGF 50 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D K + +K + +A +I A DPDREG+ + V D L+ Sbjct: 51 APD---------YVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLK-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 +K ++ R + ++L +++ + + + AR D L G ++ + Sbjct: 100 -KKGRRFHRVMFHELTKTGIQKGLTEPTELNR--NRYDAQQARRILDRLVGYQIS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L R + LS GRVQ+ + ++ R+ EI F ++++ + A + RF A Sbjct: 154 LWRKV--RNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + ++ A+ +V+ +S Q V K + PF+ S LQ EA Sbjct: 212 KGT------KNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAI 265 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G +A+ + + Q+LYE LITY R+D + E A A+ + SV Sbjct: 266 RKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPE--AAHEALAHIRSVF 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D P R +K DAH AI PT S L++++ +Y LI ++ Sbjct: 324 GNDYAPD-----RPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKR 378 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD----EENDGTPLP 465 ++ +A + I + + G+ L +E +++ G LP Sbjct: 379 FVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLP 438 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 + + + L + + + T PP F++A+L+ + +G+G Sbjct: 439 QLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELE-----------------ENGIGRP 481 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQIS 582 +T A I+ + +G++ + T+ G + L E + TA+ E+ L +I Sbjct: 482 STYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIE 541 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF-----RGIVAPGSGGSADKKKA 631 Q + ++ G Q I+ AK G+ P G K Sbjct: 542 SDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLG 595 >UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=D0KVS8_HALNC Length = 834 Score = 462 bits (1190), Expect = e-128, Method: Composition-based stats. Identities = 148/671 (22%), Positives = 257/671 (38%), Gaps = 79/671 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G G V GH+ + D + Sbjct: 5 LVIVESPAKAKTIKKYL-------------GPGYEVLASYGHVRDLIPKDGAVDTAHDFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + ++ IK+ L + ++ A DPDREG+ + + + L A Sbjct: 52 MN----------YTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEA 101 Query: 123 PE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K + QR + ++ +AV+ A+ R S + L + AR D+L G N++ Sbjct: 102 GLLKNKTAQRVVFYEITKKAVQEAVAHPRDLS--IDLINAQQARRALDYLVGFNLS---P 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 +L + LS GRVQ+P L L+V R+ EIE F ++++ + A + Sbjct: 157 LLWKKI--NPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNA 214 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA---IVTSYNDKRESESAPLPFSLSALQ 298 + + E+ L + A+ +RI A V S + + PF+ S LQ Sbjct: 215 RLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 E ++ GLSA V+ + Q+LYE T LITY R+D L E+ A + Sbjct: 275 QEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIGD- 333 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 + LP R + +AH AI PT+ + + L +++ ++Y +I Sbjct: 334 -KYGAAYLPA----SPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMI 388 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERD---EENDGT 462 ++ + AV+ + ++L + F A L G+ L E D + ++ Sbjct: 389 FKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDR 448 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + GD++ + T+PP FT+A+L+ + + Sbjct: 449 RLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYG-----------------I 491 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A II L R ++ R TD G+ + L + + TA E L Sbjct: 492 GRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLD 551 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 +S + + M+ + ++ RQ D K P Sbjct: 552 AVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELG---IDPKSGKPVSVRLG 608 Query: 640 KSPPADEVGSG 650 + P ++G+ Sbjct: 609 RFGPFAQIGTK 619 >UniRef50_C8L8E9 DNA topoisomerase n=7 Tax=Staphylococcus aureus RepID=C8L8E9_STAAU Length = 700 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 173/638 (27%), Positives = 306/638 (47%), Gaps = 31/638 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-----VTWCIGHLLEQAQPDAYDSR 57 L + EKPS A ++ V K +K +G++E + Q+ +TW +GHL+E +P YD + Sbjct: 4 LILCEKPSQAMDLSTVFAKK-KKQNGYMEISDEQLNVSGFLTWAVGHLVELKEPQEYDEK 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEA--SEIVHAGDPDREGQLLVDEV 115 Y ++ + + + +Q + Q N IK+ E E++ A DP REG+ + ++ Sbjct: 63 YKNFSTYPILLEKDDFQFKVSDKTKDQFNNIKKIFKENKIDEVIIATDPAREGENIAYKI 122 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L+ L++ + ++R + ++ +A + + AR +DWL GIN Sbjct: 123 LNQLKVT--DKVTIKRLWLTSKVESSIRKAFKNILPKEKTYGFYKEGRARELSDWLVGIN 180 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 ++R +T + R G GV+ +GRV +P L +V R+ I+ F K F++V A I E Sbjct: 181 LSRHFTKISRELGNDGVIHIGRVSSPTLNMVYNRENNIKGFKGKKFYKVSATINKDEQEV 240 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 T + ++ + LH L E+ + ++ Q +VT + P + LS Sbjct: 241 KTELKNKFDSEDE--------LHEFLFENDITDLT-QKGLVTDIEKEIGYTMPPKFYDLS 291 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 ALQ + ++ +SA+ L+I Q LYE KLITYPR+D RY+ E+ ++ + Sbjct: 292 ALQEDMNDKYKISAKRTLEIAQTLYE-KKLITYPRTDSRYITEDEKEMLLENID----YL 346 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQF 414 ++ + + N + K++ H+AI+ T + ++L E E VY I + M F Sbjct: 347 KEITKINLNNELTNNSLINPSKIEDHYAILITGNDFNKVDLKEEEINVYKSILQNVAMNF 406 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 + IE+ + K F K + + + G++ LL ++ EE +P K +E+ Sbjct: 407 MDKEQYETTTIEIAVKKLMFEVKGKIIQDNGFKALLNKQKTSEE----TIPNFEKNEEVD 462 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 E +++E++T PP+ +T+ TLL AM ++D+ LK L+ GLGT ATRA IIE Sbjct: 463 IE-LDLLEKETTPPKRYTEKTLLKAMANPIETLEDEGLKSTLKEVKGLGTPATRADIIEN 521 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L K ++ + I+ T G L + ++PD+T WE L IS+ + F+ Sbjct: 522 LKKNKYIQVQKNKIYITKNGILACLLLEGHLLSKPDLTGQWEKYLNGISKGEKDDDSFIN 581 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKA 631 + + + I++ + + S + K A Sbjct: 582 TINEMIKKTINEEVKNKESIQKVAKEKVSTNNIAKCPA 619 >UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID=D0LEI6_GORB4 Length = 1031 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 138/634 (21%), Positives = 241/634 (38%), Gaps = 88/634 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-PDAYDSRYAR 60 RL I E P+ AR IA L G+ VV GH+ + + ++Y Sbjct: 17 RLVIVESPTKARKIAGYL-------------GSNYVVESSRGHIRDLPRGAADVPAKYKG 63 Query: 61 WNLADLPI-VPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A L + V E ++ P + +K + + E+ A D DREG+ + +L+ Sbjct: 64 QPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLE 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ + V+R + +++ A+ A + R + L + R D LYG ++ Sbjct: 124 TLK----PKIPVKRMVFHEITEPAIRAAAENPRDLD--IDLVDAQETRRILDRLYGYEVS 177 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---VTPADE 234 +L + + LS GRVQ+ ++V R+ E FV+ +++++ A++ + + Sbjct: 178 ---PVLWKKVMPK--LSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQ 232 Query: 235 RFTAIWQPSEACEPYQDEEGR------------LLHRPLAEHVVNRISGQPAIVTSYNDK 282 F A + + +L A + + + G V+S +K Sbjct: 233 TFNARLVGVDDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEK 292 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PF S LQ EA ++ S+ + I Q+LYE + ITY R+D L E Sbjct: 293 PYTRRPYAPFMTSTLQQEAGRKLRFSSDRTMRIAQRLYE-NGFITYMRTDSTTLSESAI- 350 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDK-KVDAHHAIIP------TARSSAINL 395 NA A +L V P R K +AH AI P T A L Sbjct: 351 ------NAARAQARELYGDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQL 404 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRTLL 450 +E ++Y LI ++ + DA + + F A R + G+ + Sbjct: 405 EADEFRLYELIWQRTVASQMADAKGTTLSLRMTGTASTGETCVFAASGRTITFPGFLSAY 464 Query: 451 GSKERD-----EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 D ++ LP + +G L + T PP FT+A+L+ + + Sbjct: 465 VETVDDLAGGQADDAENRLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELG- 523 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALF---HSLP 562 +G +T A II + RG++ KKG + + A+ + Sbjct: 524 ----------------IGRPSTYASIIGTIQDRGYVVKKGNALVPSWIAFAVVGLLEAYF 567 Query: 563 EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + D TA E L +I+ + ++ Sbjct: 568 QGLVDYDFTASLEDDLDEIASGRENRTRWLTEFY 601 >UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7W1_9DELT Length = 821 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 135/662 (20%), Positives = 247/662 (37%), Gaps = 79/662 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + I+ L K +V +GH+ + D + Sbjct: 5 LIIVESPAKVKTISKFLGK-------------DYMVDASVGHVRDLPTRDLGVDEENGFT 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + + +K +A + A DPDREG+ + V + L+ Sbjct: 52 P----------RYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLR-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R N++ +AV+ A++ + ++ L S AR D L G ++ I Sbjct: 100 -PVNSNIRRIQFNEITARAVKEALENAQDLNQ--NLFDSQQARRILDRLVGYKIS---PI 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L +N + +S GRVQ+ L L+V R++E F +++ K + F Sbjct: 154 LWKNV--KRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + + + AE + + V S +K+ P+ S LQ +A Sbjct: 212 LSG-KAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDAN 270 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G SA+ + + Q+LYE T LITY R+D + +E ++ I Sbjct: 271 RRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELI--IDRF 328 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 D P RN DAH AI P T +L + K+Y LI ++ Sbjct: 329 GADYYP-----SKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQR 383 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 ++ A F + + ++ AK L G+ + + E + LP + + Sbjct: 384 FVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETE---LPKLVE 440 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L + + ++ TQPP +++A+L+ + + +G +T A Sbjct: 441 GETLRLNELKKEQKFTQPPPRYSEASLVKTLEELG-----------------IGRPSTYA 483 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 II L R + ++ + T+ G + L E TA ES+L ++ + Sbjct: 484 AIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQ 543 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + ++ Y +++A+ R Q IV G K + P Sbjct: 544 DWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPT 603 Query: 645 DE 646 Sbjct: 604 CR 605 >UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP1_STAA8 Length = 689 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 138/672 (20%), Positives = 267/672 (39%), Gaps = 88/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K ++ V +GH+ + + + Sbjct: 5 LVIVESPAKAKTIEKYLGKKYK-------------VIASMGHVRDLPRSQMGVDTEDNYE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P+ ++ + V K+L K+ +A + A DPDREG+ + + L+L Sbjct: 52 -------PKYITIRGKGPVVKEL---KKHAKKAKNVFLASDPDREGEAIAWHLSKILELE 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K R + N++ AV+ + R + L + AR D L G N++ + Sbjct: 102 DSKEN---RVVFNEITKDAVKESFKNPREIE--MNLVDAQQARRILDRLVGYNIS---PV 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ L LV+ R+ EI NF ++++ ++ +F A + Sbjct: 154 LWKKV--KKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKS-KFNAKFLH 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+++ +L + E + + G +T+ K ++ + PF+ S LQ EAA Sbjct: 211 ------YKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + + Sbjct: 265 RKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQ-------Y 317 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 D + + D DAH AI P T LT+++ ++Y LI + Sbjct: 318 ITDKYGESYTSKRKASGKQGD--QDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWER 375 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-GTPLPVVA 468 ++ A+ +++ KF A + + G+ TL + D +++ LP + Sbjct: 376 FVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLE 435 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GD++ + E + TQPP +T+A L+ + + +G +T Sbjct: 436 QGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEEL-----------------KIGRPSTY 478 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A I+ + KR ++ + + T+ G+ + + E + T + E++L +I+E Sbjct: 479 APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD 538 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + + Q +++A+ + + G G K K A Sbjct: 539 ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS 598 Query: 641 SPPADEVGSGAI 652 + P + Sbjct: 599 NFPDCRNTKAIV 610 >UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=C9LSJ2_9FIRM Length = 836 Score = 461 bits (1187), Expect = e-128, Method: Composition-based stats. Identities = 124/651 (19%), Positives = 250/651 (38%), Gaps = 88/651 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A+ I L K +V +GHL + + S++ Sbjct: 118 LVVVESPAKAKTIEKYLGKK-------------YMVRASMGHLRDLPK-----SQFGIDV 159 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D + + +K+ A+++ A DPDREG+ + + L + Sbjct: 160 ENDFAP-----KYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGID 214 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P + R + N++ A++ A+ + + + AR D + G ++ + Sbjct: 215 PNENC---RIVFNEITKPAIQAAVKEPYPIN--LDRVDAQQARRMLDRIVGYKLS---PL 266 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L R + LS GRVQ+ + L+ R++EI+ FV ++++ V + +F A Sbjct: 267 LWRKI--KKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELAT 324 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + + +V ++ Q V + + PF+ S++Q +A+ Sbjct: 325 VDGKKLALH------SKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDAS 378 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G +++ + I Q+LYE LITY R+D L + + Sbjct: 379 RKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGT--SF 436 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP+ K DAH AI PT+ + L+ + ++Y LI ++ Sbjct: 437 GADYLPE-----KPNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQR 491 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 ++ AVF + + + A L G+ + +++++ LP +A Sbjct: 492 FVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVYADNKKEKD---VLLPELA 548 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 G+ L + T+PP + +A+L+ + + +G +T Sbjct: 549 AGEALSLLDLLPEQHFTEPPPRYNEASLVKTLE-----------------EEDIGRPSTY 591 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQISEKQ 585 A IIE + RG++ ++ ++ TD G + L E TA E+ L +I+E + Sbjct: 592 APIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGK 651 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV-----RQFRGIVAPGSGGSADKKKA 631 D ++ + +++A + ++ G + K+ Sbjct: 652 VDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQG 702 >UniRef50_B7U5A8 DNA topoisomerase n=2 Tax=Bacillus RepID=B7U5A8_BACSU Length = 776 Score = 461 bits (1187), Expect = e-128, Method: Composition-based stats. Identities = 175/640 (27%), Positives = 300/640 (46%), Gaps = 51/640 (7%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ LF+ EKP+ A+ A L K +G+ +G+V T+ GHL+E P+ + + Sbjct: 1 MKELFVCEKPNQAQDYAAALSGNFEKKNGYFLGEDGKVFTYAFGHLVELKGPEQLNWKS- 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 +L LP + +L + KQ VI + +A ++ + D REG+ + ++ Sbjct: 60 --DLDTLPYFEKNMELALIENKKKQYFVIVDLMKKAETVIISTDSGREGEHIFRKIYKLS 117 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L + ++R + D +++A +LR SE+ L + R AD+L G+N T Sbjct: 118 GL----NKPLKRLWVKDNTESGIKKAYSQLRDGSEYEGLAKAGQLRDEADFLVGVNATIL 173 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T R + + +S+GRVQTP L ++V+RD IENF + F + A + F + Sbjct: 174 AT---RLSSSRTPISLGRVQTPTLSMIVKRDYTIENFKKVEHFTLSASVKKQGIGNFELL 230 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 E+ + L + AE ++ + + + +++K E E F L++LQI Sbjct: 231 L-----------EKDQQLTKADAESILTALGNRVGL--RFDEKIEKEKPKHLFDLTSLQI 277 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL-PEEHFAGRHAVMNAISVHAPDL 358 E K+ G SA+ LDI Q LYE HK++TYPR+ +++ E F + A L Sbjct: 278 EMNKKVGWSAKKTLDILQGLYEKHKVVTYPRTSSKFVASTEEFPALLEQHKDQPLIAHIL 337 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 + ++ + KV H AII T + I L + E +Y++I ++++ F P A Sbjct: 338 ENKYEIEKTF----VNPGKVTDHEAIIITKQKPKI-LGKEEELLYDVIFKRFVAAFYPPA 392 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V++K E + F + + L E GWR++ D E L + D + Sbjct: 393 VYQKTSAEFSDGEHVFKSNEKVLIEKGWRSIY-----DAEIQKPILKDINLDD---IDDY 444 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 E+ ++T+PP+ + + TLL+ M +FV + KK+++ G+GT ATRA IIE+L KR Sbjct: 445 ELKRKETKPPKRYDEGTLLNDMENAHKFVSEAKDKKLIKEA-GIGTSATRADIIEVLCKR 503 Query: 539 GFLTKK----GRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISEKQCRYQDFM 592 F+ ++ + ST G+++ +PE + P MTA +ES+L + E +F Sbjct: 504 NFVERQTVKDKEVLVSTPLGRSVISMMPEDFLLYSPKMTAIFESMLGDVEENNLSPSEFY 563 Query: 593 QPLVGTLYQLIDQAKRT------PVRQFRGIVAPGSGGSA 626 L +Y + Q + + P G Sbjct: 564 AELENLVYGIAKQIRENIKSLESETEKEVIANCPNCGREM 603 >UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP2_VEIPT Length = 791 Score = 461 bits (1186), Expect = e-128, Method: Composition-based stats. Identities = 136/669 (20%), Positives = 248/669 (37%), Gaps = 95/669 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ ++ I L G VV +GHL + + Sbjct: 75 LVIVESPAKSKTIEKFL-------------GPNYVVKASMGHLRDLPKSQ---------- 111 Query: 63 LADLPIVPEKWQLQPRPS----VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + + PR S K ++ + + E+S ++ A DPDREG+ + + Sbjct: 112 ----IGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISWHLAYI 167 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + P R N++ AV A+D R+ + + + AR D + G ++ Sbjct: 168 LNVDPTSTC---RITFNEITKNAVAEALDSPRTID--MNMVDAQQARRVLDRIVGYKLS- 221 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +L + LS GRVQ+ + L+ R+ EI+ FV ++++ ++ + TP E F A Sbjct: 222 --PLLWKKV--CKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIA 277 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E+ + A+ +V+ I + A+VT+ ++ S A PF+ S LQ Sbjct: 278 ELTHIKG------EKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQ 331 Query: 299 IEAAKRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNA 350 + ++ A+ + I Q LYE LITY R+D + +E A + Sbjct: 332 QDGVRKLNFGAKRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFI-- 389 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNL 405 + + D P + DAH AI PT+ + L+ +E K+Y L Sbjct: 390 LRNYGEDYYPSKPNVYGSK-----GSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTL 444 Query: 406 IARQYLMQFCPDAVFRKCVIELDI-AKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 I +++ IEL++ F A + G+ + E ++ D L Sbjct: 445 IWNRFMASQMAPQQNESTTIELNVKNDYTFKATGSRVIFPGFSAVY---EDAKKEDVPQL 501 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + K + + TQPP +++A+L+ + + +G Sbjct: 502 PALKKNYAAHTVEVLPEQHFTQPPPRYSEASLIKTLEELG-----------------IGR 544 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQI 581 +T A I++ + R ++ + T+ G + L E T E L I Sbjct: 545 PSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFLITYFEKIINTGFTRDLEEELDAI 604 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI----VAPGSGGSADKKKAAPRKRS 637 + + Y + Q ++ A + + + K K Sbjct: 605 ASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASMESDEICELCNSPMVYKFGRYGKFL 664 Query: 638 AKKSPPADE 646 A + P + Sbjct: 665 ACSNFPECK 673 >UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms RepID=D0LR99_HALO1 Length = 894 Score = 461 bits (1186), Expect = e-128, Method: Composition-based stats. Identities = 139/659 (21%), Positives = 240/659 (36%), Gaps = 95/659 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR I L G V +GH+ + + Sbjct: 139 LVVVESPAKARTIGKYL-------------GPDYTVKASVGHIKDL-------PKNKIGV 178 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D PE K ++ I++ E+ A DPDREG+ + + + ++ Sbjct: 179 DVDQAFEPE---YVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIK-- 233 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R LIN++ + V AI + AR D L G ++ I Sbjct: 234 -PINDNIKRILINEITKKGVNHAIANPTVLD--TNKTDAQQARRILDRLVGYEIS---PI 287 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ + L+V RD+EI F ++++ V P F A Sbjct: 288 LWKKV--RRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHR 345 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + E A + + + Q A V K PF S LQ EA+ Sbjct: 346 WDGAKAEPKTE------AQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEAS 399 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ SA+ + + Q+LYE LITY R+D + ++ A + + Sbjct: 400 RKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQ--GTY 457 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA----------KVYN 404 P+ LP R DAH AI PT K+Y Sbjct: 458 GPEFLPAKPHTYKSPKRA-----QDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYT 512 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE------ 458 LI ++++ AV+ + +++ + A + + G+ ++ ++E D+E Sbjct: 513 LIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAA 572 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + LP + +G + + + TQPP FT+A+L+ + Sbjct: 573 DQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELE----------------- 615 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWE 575 G+G +T A II + RG++ ++ T+ G + L E D TA E Sbjct: 616 ERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAME 675 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR-----GIVAPGSGGSADKK 629 + L ++ E + +++ + I+ AK R V G K Sbjct: 676 ADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIK 734 >UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID=A0LDV2_MAGSM Length = 783 Score = 459 bits (1182), Expect = e-127, Method: Composition-based stats. Identities = 137/688 (19%), Positives = 259/688 (37%), Gaps = 94/688 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + I E P+ A+ I L + G V GH+ + + + Sbjct: 4 VVIVESPAKAKTINKFLGR-------------GYKVVATYGHIRDLPSKNGSVDTEHGFA 50 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + TK+++ + + + A +++ A DPDREG+ + V + L Sbjct: 51 M----------KYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHVYEVLNEK 100 Query: 123 PE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + QV+R + +++ A++ A+ R + + + AR D+L G N++ Sbjct: 101 KLLENVQVKRVVFHEITKTAIQDAVAHARDVD--MDMVNAQQARRALDYLVGFNLS---P 155 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 +L R + LS GRVQ+ L LV R+ EI+ F A++++ + A A Sbjct: 156 LLWRKV--RRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEA 213 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + + + A+ ++ + +P V+ K+ + PF S LQ EA Sbjct: 214 RLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQEA 273 Query: 302 AKRFGLSAQNVLDICQKLY------------ETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 +++ G SA+ + + Q+LY ET LI+Y R+D L E + Sbjct: 274 SRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQIE 333 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYN 404 + + LP+ + + +AH AI PT L +++ ++Y Sbjct: 334 I--RYGKEYLPK----SPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYE 387 Query: 405 LIARQYLMQFCPDAVFRKCVIELDI------AKGKFVAKARFLAEAGWRTLL-------- 450 LI ++ + A K L + A +F A +A AG+ + Sbjct: 388 LIWKRTVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVS 447 Query: 451 -GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQD 509 +E D++++ + LP + G +L + + + T+PP +T+ATL+ + Sbjct: 448 AQDREDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYG----- 502 Query: 510 KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT--- 566 +G +T A + L RG++ R + D G + L + + Sbjct: 503 ------------IGRPSTYAPTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYV 550 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI-----DQAKRTPVRQFRGIVAPG 621 + TA+ E L +S + + M+ Q I +K + P Sbjct: 551 DYNFTANLEDQLDAVSRGEKSWVPLMEDFWQPFIQQITLKDETTSKEEVTTEQIDEPCPK 610 Query: 622 SGGSADKKKAAPRKRSAKKSPPADEVGS 649 G K K A P + Sbjct: 611 CGAPLSIKLGRFGKFKACTGYPECKHTE 638 >UniRef50_A5ZNQ6 DNA topoisomerase n=2 Tax=Clostridiales RepID=A5ZNQ6_9FIRM Length = 635 Score = 459 bits (1182), Expect = e-127, Method: Composition-based stats. Identities = 171/566 (30%), Positives = 278/566 (49%), Gaps = 48/566 (8%) Query: 68 IVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQLAPEK 125 ++PE W+ Q + S Q ++K LH A EI+ A D REG+L+ V + E Sbjct: 1 MIPENWKYQIKESTKGQFRILKELLHRADVTEIICATDAGREGELIFRLVYN----QAEC 56 Query: 126 RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGR 185 + +R I+ + +A+ +L+ E+ L SA+AR+ ADWL GIN TR +T+L Sbjct: 57 KLPFKRLWISSMEEKAILEGFQQLKDGHEYDDLYYSAVARSEADWLVGINATRLFTVL-- 114 Query: 186 NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEA 245 Y L VGRVQTP L ++V R++ IENF + ++ V H++ + ++ Sbjct: 115 ---YHHRLIVGRVQTPTLAMLVEREKSIENFQKEKYYLV--HLLMDGLDAVSS------- 162 Query: 246 CEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRF 305 R+ + A ++ + + A + S +++ P + L+ LQ EA + Sbjct: 163 ---------RIKEKSAAVQMMEDMKDETAQILSVKKEKKKVQPPKLYDLTTLQREANRLL 213 Query: 306 GLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVD 365 G +AQ LD Q LYE KL+TYPR+D +YL ++ V+ A++ P++ + + Sbjct: 214 GFTAQQTLDYTQSLYE-KKLVTYPRTDSQYLTDDMEENALLVVGAVNSMFPEMSIKG-SE 271 Query: 366 PDIRNRCWDDKKVDAHHAIIPTARSSAINL---TENEAKVYNLIARQYLMQFCPDAVFRK 422 PDI+ R + KKV HHAIIPT + ++L E ++ LIA + L + ++ Sbjct: 272 PDIK-RLLNSKKVSDHHAIIPTVEITNMDLKALPGGEKEILMLIASKLLCASEQEYIYES 330 Query: 423 CVIELDIAKGKFVAKARFLAEAGWRTL-------LGSKERDEENDGTPLPVVAKGDELLC 475 E+ F A + + + GW+ + G E + + P + G C Sbjct: 331 IKTEISCHGELFTASGKNVLQYGWKEVEERFFKSYGKNAEKPEEEESDFPDIKIGQVFEC 390 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 + E T PP+H+T+ TLLSAM +D GLGT ATRA IIE L Sbjct: 391 VVVKFSEHFTAPPKHYTEDTLLSAMEHAGSSDTIEDA-----ERKGLGTPATRAAIIEKL 445 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 ++GF+ +K + I T G+ L LPEM P +TA WE+ LT IS Q ++F+ + Sbjct: 446 IEKGFIERKKKQILPTADGRNLIRILPEMIKSPKLTAEWENDLTLISRGQKNVEEFLFEI 505 Query: 596 VGTLYQLIDQAKRTPVRQFRGIVAPG 621 + +L+ + PV +++ + + G Sbjct: 506 EKMVTKLVSDNGQ-PVEEYQKLFSDG 530 >UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E2F6_DICTD Length = 696 Score = 459 bits (1181), Expect = e-127, Method: Composition-based stats. Identities = 140/667 (20%), Positives = 252/667 (37%), Gaps = 87/667 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I +L K + V GH+ + + + + Sbjct: 5 KLIIVESPAKAKTIEKILGKEFK-------------VLASYGHIRDLPEKELGVDIENNF 51 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + PS K ++ IK +A ++ A DPDREG+ + +++ L+L Sbjct: 52 KP----------KYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHLVEELKL 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 +++ R +++ P+A+ AI R + + AR D L G ++ Sbjct: 102 ---PKEKFTRIEFHEITPRAILEAIKNPREID--LDRVEAQQARRILDRLVGYELSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L + R+EEIE F+ ++++ + + Sbjct: 157 EKVRKG-----LSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEEKVLYG---- 207 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 Y+DEE + + ++ ++ + K E + P PF S LQ EA Sbjct: 208 ---KLILYKDEEVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEA 264 Query: 302 AKRFGLSAQNVLDICQKLYETH-------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +KRFG + I Q LYE LITY R+D + E + S Sbjct: 265 SKRFGFPVGKTMKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIE--SGF 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + + + + DAH AI PT+ LT+ + K+Y LI + Sbjct: 323 GKEYVGKEHKEKKKLG------VQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWER 376 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVV- 467 ++ A+F I + F++K + L AG+ +L KE + EE D + V Sbjct: 377 FIASQMNHAIFEVVEIYIKGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVP 436 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G + + T+PP +T+ATL+ + +G +T Sbjct: 437 EEGKNVKLTTLIPRQFFTEPPPRYTEATLVRTLEKYG-----------------VGRPST 479 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEK 584 A IIE L +R ++ K R + T GK + L + TA E L +I Sbjct: 480 YATIIETLKERKYVEVKDRTLVPTTLGKVVNDFLTKQFPHLIDVKFTARMEEDLDKIESG 539 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKK-KAAPRKRSAK 639 + + + ++ + +++ + + + + P G + + + Sbjct: 540 KVKAIEVLKKFYPAFKEELEKVSKNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACS 599 Query: 640 KSPPADE 646 + P Sbjct: 600 RYPECKY 606 >UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B3EPW7_CHLPB Length = 804 Score = 459 bits (1180), Expect = e-127, Method: Composition-based stats. Identities = 139/682 (20%), Positives = 255/682 (37%), Gaps = 106/682 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPD---AYDSRYA 59 L + E PS A+ I L G+ +V +GH+ + + + +D+ Y Sbjct: 15 LIVVESPSKAKTINKYL-------------GSDYLVFASVGHIKDLPKKEIGLDFDNNYE 61 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + + K + +K+ +A++I+ A DPDREG+ + + + + Sbjct: 62 P-------------RYEVISGKEKVVRQLKKLAGQANDILIATDPDREGEAIAWHIANEV 108 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 A ++ V R L N++ +A+ AI+ L S R D + G ++ Sbjct: 109 DAA---QKPVHRVLFNEITKKAILEAINDPLQID--YRLVRSQQTRQGLDKIVGYKISPF 163 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 + LS GRVQ+ L L+ R+ EI+ F K+++ + A T + E F+ Sbjct: 164 LWNVVMRG-----LSAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFTTGSGETFSTK 218 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ + + ++ AE + I + V + + P PF+ S LQ Sbjct: 219 LVRIDSN------KAEITNQSDAEKTASDILSRIYGVAEITPRVQQRKPPFPFTTSLLQQ 272 Query: 300 EAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 A+ + G ++ + + Q+LYE LITY R+D + E + Sbjct: 273 AASNQLGFGSKKTMRVAQQLYEGIDLGPEGATGLITYMRTDSTRVSGEAVEQAERFIT-- 330 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 P+ + K DAH AI PT L+ ++ K+Y LI Sbjct: 331 QHFGPEFTGGGQAAKKGK------KTQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELI 384 Query: 407 ARQYLMQFCPDAVFRKCVIE--LDIAKGKFVAKARFLAEAGWRTLLGSK----------- 453 +++L A + ++ + F A + G+ + + Sbjct: 385 WKRFLASRMAPAKIEQTRVDVADHEKQFIFRASGSNVLFPGFLKVYNEQKELDYEARKST 444 Query: 454 -ERDEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 E +E+ LP + ++L + + + T+PP FT+A+L+ + Sbjct: 445 REDEEKEQIVKLPRNLTVNEKLTLDTLDKKQSFTRPPARFTEASLVKELDNYG------- 497 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGK----ALFHSLPEMATR 567 +G +T AGI L R ++ + + I T+ GK L + P++ Sbjct: 498 ----------IGRPSTYAGIFSTLQDRRYVELEKKKIIPTELGKDVSMILVANFPDLF-N 546 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGIVAPGSG-G 624 TAH E+ L +I+ Y+ + L + K P+ + G G Sbjct: 547 VTFTAHMENELDKIAAGDDEYEQVLDSFYKPLESALSVRKNDPLLPQNTDAETCDKCGKG 606 Query: 625 SADKKKAAPRKRSAKKSPPADE 646 K A K S PA + Sbjct: 607 KMIIKWTASGKFLGCSSYPACK 628 >UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria RepID=B1M0P4_METRJ Length = 894 Score = 458 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 140/668 (20%), Positives = 257/668 (38%), Gaps = 79/668 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ + E P+ A+ I L + V GH+ + D Sbjct: 1 MKVVVVESPAKAKTINKYLGR-------------DYEVIASFGHIRDLPPKDGSVDPEQD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL- 119 + + W+L R + ++ I + + A +++ A DPDREG+ + VL+ L Sbjct: 48 FRMV--------WELADRGASR--VSEIAKAVKGADKLILATDPDREGEAISWHVLEALT 97 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 K V+R N + +VE+A+ + R + L + LAR D+L G N++ Sbjct: 98 ARKALKGIPVERVTFNAITKASVEQAMRKPREIDQ--ALVDAYLARRALDYLVGFNLS-- 153 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +L R G S GRVQ+ L LVV R+ EIE F ++++ + A + T F A Sbjct: 154 -PVLWRKL--PGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ + + G A + V S K PF+ S LQ Sbjct: 211 LVGADGKRIQRLDVGT---GEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G++ + + Q+LY ET +ITY R+D + E V+ Sbjct: 268 EASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVI---- 323 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIA 407 + + V D + +AH A+ PT ++ A +L +A++Y LI Sbjct: 324 --GKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGS-KERDEENDGT 462 + + A + +++ G A + + G+ TL K+ +E+ + Sbjct: 382 TRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESR 441 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + GD L E+ + T+PP +++A+L+ M + + Sbjct: 442 RLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A +++ L R ++ + + + D G+ + L D TA E L Sbjct: 485 GRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 ++S + ++ ++ I + K V + G K + + Sbjct: 545 RVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGS--NPR 602 Query: 640 KSPPADEV 647 P Sbjct: 603 TCPTCGSG 610 >UniRef50_D1AS14 DNA topoisomerase type IA central domain protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AS14_SEBTE Length = 764 Score = 458 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 202/641 (31%), Positives = 323/641 (50%), Gaps = 26/641 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEK ++A AIA + DG+++ G+ +TW GHLL +P+ YD ++ + Sbjct: 1 MKLIIAEKRNVATAIATAIDGAQETKDGYVKKGD-YYITWASGHLLSLKEPEDYDPKFQK 59 Query: 61 WNLADLPIVPEKWQLQPR-PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 WN+ DLP W+L+P KQLN+IK L E S ++HA DPD EGQL+ DE+L Y Sbjct: 60 WNIPDLPFNFPNWELKPINAGSKKQLNIIKDLLKECSGVIHACDPDDEGQLIGDEILLY- 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ V+R LIND N + + + +L N ++ L +SA AR AD + GIN++R Sbjct: 119 ---HDYKKPVERMLINDNNTEYIRKLFTKLEDNRKYESLGISAAARRIADAIIGINLSRF 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 Y+ L VGRV+ P LGLVV RD IEN + + + ++ I D+ Sbjct: 176 YSC-----KSSKTLHVGRVKAPTLGLVVNRDYAIENHIKQLHYILRI-IANNNDKDNNIT 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + +E+ ++ E V I+ + K +++ PL F++ LQ Sbjct: 230 FTFQKNANTPVNEDKLIIDLDYIEKVQAEIADIKDYKVNVTSKILTKNPPLVFNIDKLQA 289 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +F +AQ VL+I Q L TH++ITY RSD +YL EEHF ++ I + L Sbjct: 290 YCNNKFSYTAQEVLEITQVLQATHQIITYNRSDSQYLNEEHFQEAPQLIEIIKENLN--L 347 Query: 360 PQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 +D + +++ +D KV AHH IIPT R LTE E VY +IA YL+QF P Sbjct: 348 SLDNIDTNRKSKVFDSSKVTAHHGIIPTHTRFDLSKLTEKERNVYQVIAEFYLVQFMPPE 407 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 ++ + F R + + G++ L S ++E + + Sbjct: 408 KLKETTGIFKVKDYDFKTTDRTVQDLGYKKFLNSINEEKEEEEKSNISKFEDRLYDFVNF 467 Query: 479 E--VVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG--------LGTEATR 528 + R+T+PP+ +T+ATL+S MT IA+++++ ++K+IL D +GT ATR Sbjct: 468 ATPIDTRETKPPKPYTEATLISDMTSIAKYIKNPEIKEILLRKDKDKEGAKGSIGTPATR 527 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHS-LPEMATRPDMTAHWESVLTQISEKQCR 587 A +E L G+L +KG+ I +T+ GK +++ LP+ D+TA W + I Sbjct: 528 ASTVEELINDGYLERKGKQIRATEKGKNFYNNVLPDEIKTADLTALWWVIQEDIIAGTKT 587 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADK 628 D + ++ Q ++ K +R ++ P K Sbjct: 588 ITDLTDSVFKSVIQAMETNKDIKIRHKDDVICPKCNDGFLK 628 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 457 bits (1177), Expect = e-127, Method: Composition-based stats. Identities = 144/668 (21%), Positives = 260/668 (38%), Gaps = 86/668 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I +L G+ V +GHL + Q + Sbjct: 33 HLIIVESPAKAKTIERIL-------------GSDYKVLASMGHLRDLPQRTLGVDVANDF 79 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + +++ +++ +I+ A DPDREG+ + + L + Sbjct: 80 KP----------EYVSSAERADVIENLQKEANKSKDILLATDPDREGEAISWHLSKLLDV 129 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 P R +++ P A++ A+ + + AR D L G ++ Sbjct: 130 DPRSNA---RIAFHEITPPAIKEAVLHPEPID--LNRVDAQQARRVLDRLVGYKLS---P 181 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 L + LS GRVQ+ L+ R+EEI F +++ V+ T E F A Sbjct: 182 WLWKQI--YRGLSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLT 239 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + +E ++ + A+ VV I QPA +TS ++ A P++ S +Q +A Sbjct: 240 QVDG------KEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKPPYTTSTMQQDA 293 Query: 302 AKRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 R ++ + + Q LYE LITY R+D + +E + V Sbjct: 294 VNRLNFGSKKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIE--RV 351 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 + D LP P++ R D DAH AI PT A + L+ ++ ++Y LI Sbjct: 352 YGKDYLP---PKPNVYARGKDS--QDAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWN 406 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP-LPVV 467 ++L + + L A + G+ L KE+ ++N+ P LP + Sbjct: 407 RFLASQMAPQISQATNAVLQSGIYTLRATGTQILFDGFTVLRTVKEKKQDNEELPILPAL 466 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 KG +L K E + T PP +T+A+L+ + G+G +T Sbjct: 467 HKGHTVLNTKAEGEQHFTAPPPRYTEASLIKTLE-----------------EKGIGRPST 509 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEK 584 A I++ + +R ++ K+G+ TD G + L + D TA E+ L +I++ Sbjct: 510 YAPILDTIQRRKYVEKEGKQFVPTDIGFKVTDLLKKYFAGIVSVDFTAQLETWLDKIADG 569 Query: 585 QCRYQDFMQPLVGTLYQLIDQAK------RTPVRQFRGIVAPGSGGSADKKKAAPRKRSA 638 + Y+ M + + A + ++ ++ G K + K A Sbjct: 570 KATYKKVMSGFWDVFEKELQNANLEAAKAKEENQEVSDVICEKCGAHMIVKMSRYGKYLA 629 Query: 639 KKSPPADE 646 + P+ + Sbjct: 630 CPNFPSCK 637 >UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EA7F Length = 901 Score = 457 bits (1175), Expect = e-127, Method: Composition-based stats. Identities = 144/677 (21%), Positives = 253/677 (37%), Gaps = 75/677 (11%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG--------------QVVTWCIGHLLE 47 L +AEK A+ I+ L K + + N V+T GHLL Sbjct: 3 ILNVAEKNDAAKNISFFLSKGSARKRESLSVYNKIYEFEFKLFNQNCKMVMTSVSGHLLN 62 Query: 48 QAQPDAYDSRYARWNLAD---LPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDP 104 P + W+ D L VP + + + Q N +K + ++ D Sbjct: 63 YCFP----PTHKNWSTTDPSSLFTVPVN-KFCAKENFKTQ-NNLKNEVKYCDTLIIWTDC 116 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREG+ + E++D + + ++ R +++ +V RAI+ L ++ L + Sbjct: 117 DREGENIGFEIIDVCKKV-KPNIKIYRAKFSEITSASVMRAINNLEMPNK--SLSDAVDV 173 Query: 165 RARADWLYGINMTRAYTILGRNAGYQG----VLSVGRVQTPVLGLVVRRDEEIENFVAKD 220 R D G TR ++ + V+S G Q P LG VV R + I F+++ Sbjct: 174 RMELDLRIGAAFTRFQSLYLQKKFPDNFKSTVVSYGSCQFPTLGFVVERFKNISQFISEP 233 Query: 221 FFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSY 279 F+ ++ + + E R+ + E + ++ A V Sbjct: 234 FWRIEVKDNSNK-----------NLIVDFNWERNRMFDKSCCEVLYDKCIESNLAKVIKV 282 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 + K +S+ P P L+ A+K+ ++A+ L +KLY T I+YPR++ P+E Sbjct: 283 DSKPKSKYRPKPLDTVELEKLASKKLKINAKLALKTAEKLY-TQGYISYPRTETNIFPKE 341 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENE 399 + + + +VD N K AH I P +S NLT E Sbjct: 342 LDLRPLVQRQTTDSNWGEFALKVLVDGP--NPNQGTKSDQAHPPIHPIKYAS--NLTGVE 397 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 +Y LI R +L +A + +E+D+A F AK + + + + + Sbjct: 398 KNIYELIVRHFLACLSKNAEGIETAVEIDLANEIFTAKGLMITARNYLDVYPYDVWNAKE 457 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 + + GD +VE +T PP T+A L++ M Sbjct: 458 ----INLYNVGDVFKP-AVSLVEGKTNPPELLTEADLIALMEK----------------- 495 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKG-RYIHSTDAGKALFHSLPEM---ATRPDMTAHWE 575 G+GT+AT A IE + R ++ K +Y G L + +P++ A E Sbjct: 496 HGIGTDATHADHIETIKARFYVGLKNDKYFVPRTLGMGLVEGYNNVGFEMAKPNLRAELE 555 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 + L+ I+ + QD + + + + K F I + G + + Sbjct: 556 ADLSSITRNEKMPQDVLNKHINKYKNIFEVVKTNSKNLFEIINSYIQGNNPI--SSEKEN 613 Query: 636 RSAKKSPPADEVGSGAI 652 K E G+ I Sbjct: 614 NVPKSPMNCRECGNPMI 630 >UniRef50_C3RPW1 DNA topoisomerase n=1 Tax=Mollicutes bacterium D7 RepID=C3RPW1_9MOLU Length = 795 Score = 456 bits (1174), Expect = e-126, Method: Composition-based stats. Identities = 174/657 (26%), Positives = 295/657 (44%), Gaps = 46/657 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDG--FIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 M+L IAEKP++++ + D +PH K G G +GHL A P+ + Y Sbjct: 1 MKLVIAEKPNVSKQLRDAF-EPHAKYGGAPGYFIGEKYTFCCALGHLFTFAMPEEINDNY 59 Query: 59 ARWNLADLPI-VPEKWQLQPRPSVTKQL-NVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 R+ L DLP+ +P L+ VTKQ +V+K+ EI+ A DPDREGQ + + Sbjct: 60 KRYALEDLPLNLPNDIPLKLTNDVTKQYYSVLKKLFKTGNFDEIIVATDPDREGQSIYER 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + + P + R I++ P + +A++ + N + L ++ RA D+L G+ Sbjct: 120 IKSQTRNFP--KVPESRIWISEWTPSGLIKAMNNKKPNDNYRGLKAASECRAIEDYLIGM 177 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RA T+ + G V+S+G QTP L ++V R+ EI NF A+D+ +V E Sbjct: 178 NGSRAMTV--KFGGANNVISIGSTQTPTLYMIVSREREITNFKAEDYGVPFIELVNDKGE 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 T R L A+ ++ + + +KR + + Sbjct: 236 LLTLKHTSK-----------RHLSLLEAQTTQKKLLQHQGTIVNIEEKRRTSKPMKLPNA 284 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA-GRHAVMNAISV 353 + +Q E K++G +A +I Q LY+ L TYP + R + + + + N + Sbjct: 285 TDIQKEMNKKYGFTADKTSNILQTLYQDKHLTTYPGTKAREISKSSATLSLNTIKNLLKN 344 Query: 354 HAPDLLPQPVVDPD--IRNRCWDDKKVDAHHAIIPT----ARSSAINLTENEAKVYNLIA 407 + + +++ + I C ++ + AH AI P + +LT++E KVY+ I Sbjct: 345 NVMPKETEKILENNWEIAKHCIANEGL-AHEAITPVFGQINQKDIDSLTQDERKVYDEIV 403 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 ++++ F P+AVF +I I F+AK + + G++ ++G E + LP Sbjct: 404 KRFVQAFFPEAVFSDTIITTTIDSENFIAKGSIIIQKGYKEIMGVGEDN------LLPAF 457 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL--RATDGLGTE 525 G + K + E+QT PP +T +TLL AM +RFV DK KIL + +GLGT+ Sbjct: 458 VNGKKYPISKVGIEEKQTTPPPRYTTSTLLEAMENASRFVDDKHYAKILSSKEVNGLGTD 517 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE--MATRPDMTAHWESVLTQISE 583 TR+ I+ L +R + KG+ I+ T LF LP P A E L + Sbjct: 518 RTRSDILNKLLQRNYYEFKGKTIYPTQKAIDLFKVLPSSGELDSPIHKAKMEEKLALVEL 577 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGGSADKKKAAPR 634 + ++++Q + + + K + I P GG + Sbjct: 578 GKLSKKEYLQEVYQDINSFVQAVKDARQQVIANNMTSSKIKCPECGGGLLVSSKVVK 634 >UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota RepID=TOP3A_DROME Length = 1250 Score = 456 bits (1174), Expect = e-126, Method: Composition-based stats. Identities = 150/690 (21%), Positives = 260/690 (37%), Gaps = 85/690 (12%) Query: 1 MR-LFIAEKPSLARAIADVLPKPH-RKGDGFIECGN-------------GQVVTWCIGHL 45 M+ L +AEK A+ IA +L ++ +G+ V+T GH+ Sbjct: 26 MKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHM 85 Query: 46 LEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL----HEASEIVHA 101 ++ A + Y W D + + V IKR L ++ Sbjct: 86 MQLA----FQVSYKNWRTVDPR---SLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIW 138 Query: 102 GDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS 161 D DREG+ + E++D + A + V R +++ AV RA+ +L + V Sbjct: 139 TDCDREGENIGYEIIDVCR-AIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVD 197 Query: 162 ALARARADWLYGINMTRAYTILGRNAGYQGV----LSVGRVQTPVLGLVVRRDEEIENFV 217 R D G +TR T+ + + + +S G Q P LG V R +EIE FV Sbjct: 198 V--RTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFV 255 Query: 218 AKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP---A 274 ++ F+++K + + + RL + E+ + +P A Sbjct: 256 SEPFWKIKV------------LHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRA 303 Query: 275 IVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCR 334 +V S K + + P P ++ +++ LSA+ + I +KLY T I+YPR++ Sbjct: 304 LVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLY-TKGFISYPRTETN 362 Query: 335 YLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN 394 +E FA V Q V++ R +K AH I PT + N Sbjct: 363 QFSKE-FALAPLVEMQTGHRDWGAFAQRVIEWGPNPR-NGNKSDQAHPPIHPTKLA--EN 418 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE 454 L NEA+VY L+ R +L DAV + ++ +DIA KF A + E + + Sbjct: 419 LQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVY-- 476 Query: 455 RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 ++ + G + + E T P T+A L++ M Sbjct: 477 --DKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEK------------ 522 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDM 570 G+GT+AT A I + +RG++ ++ G L+ M +P + Sbjct: 523 -----HGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQL 577 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLY----QLIDQAKRTPVRQFRGIVAPGSGGSA 626 A +E L I + Q + + + Q+ D+ + I + SA Sbjct: 578 RAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSA 637 Query: 627 DKKKA---APRKRSAKKSPPADEVGSGAIA 653 ++ A AP + + +A Sbjct: 638 VQEGADGSAPSHGIIQSIFQCPKCNEAPLA 667 >UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMY2_9BACT Length = 782 Score = 456 bits (1173), Expect = e-126, Method: Composition-based stats. Identities = 144/665 (21%), Positives = 256/665 (38%), Gaps = 80/665 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I L + + V +GH+ + Sbjct: 5 LVIVESPAKARTIEKYLGRNFK-------------VLASVGHVKDLPASSL--------- 42 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 DL E + K ++ +K+ + A I A DPDREG+ + + + L Sbjct: 43 GVDLDNDFEP-KYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIAWHIAEELG-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + + ++ R L N++ + +E I +E + AR D L G ++ + Sbjct: 100 KKNKGKIYRVLFNEITKKGIEDGIKNTGPINE--NRTNAQQARRILDRLVGYLVS---PL 154 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L ++ Y LS GRVQ+ L L+V R+EEIE F ++++ + A Sbjct: 155 LWKSLKYG--LSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARL-- 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E ++ R+ + AE V+ + V K E APLPF S LQ EAA Sbjct: 211 ----EKKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAA 266 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ SA+ + + Q+LYE LITY R+D + + + + Sbjct: 267 RKLSFSAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIE--KQY 324 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + L + V + DAH AI PT+ + L ++ K+Y LI + Sbjct: 325 GKEFLSKGVKGGSKKKNV-----QDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDR 379 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVA 468 ++ DAV+ + I + ++ + + G++TL + +E D + V Sbjct: 380 FVSSNMADAVYDQNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVK 439 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L EK + + TQPP +++ATL+ + +G+G +T Sbjct: 440 EGETLNPEKHDSKQMFTQPPARYSEATLVKTLE-----------------AEGIGRPSTY 482 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEKQ 585 A II L R + + + T+ G+ + L + P TA E L + + Sbjct: 483 ASIISTLIDREYANMEEKRFKPTELGRVVCSLLIANFDRIFEPKFTAGMEEDLDSVEAGE 542 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG-IVAPGSGGSADKKKAAPRKRSAKKSPPA 644 ++ ++ +++A++ + + P K A S P Sbjct: 543 LTWKGVLRDFYAKFKPELEKAEKQFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYPE 602 Query: 645 DEVGS 649 + S Sbjct: 603 CKFTS 607 >UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus RepID=Q7NGH1_GLOVI Length = 765 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 138/653 (21%), Positives = 246/653 (37%), Gaps = 92/653 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ +L K VV GH+ + Q + + + Sbjct: 5 LVIVESPAKAKTISKILGK-------------NFVVKASAGHIRDLPQKEMGVNVKNDFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + P + + +K A + A DPDREG+ + + L + Sbjct: 52 P----------KYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIAWHLAQILDIP 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + ++QR +++ QA++ A+ R + + AR D L G ++ + Sbjct: 102 GD---RLQRIEFHEITKQAIQNAVAHPRDID--INRVDAQQARRILDRLVGYKLS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + Q LS GRVQ+ + L+ R++EI+ FV+++++ V A T Sbjct: 154 LWKKV--QRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPF--- 208 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 S + ++ L + A VV ++G + V S + + PF S LQ E A Sbjct: 209 SADLVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGA 268 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 GL+ + + I Q+LYE LITY R+D + EE + ++ + Sbjct: 269 SALGLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFI--LAAY 326 Query: 355 APDLLPQPVVDPDIRNRCWDDKK--VDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 P R R + KK DAH + PT + + LT ++ K+Y LI Sbjct: 327 GKSYYP-------SRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIW 379 Query: 408 RQYLMQFCPDAVFRKCVIELDI------AKGKFVAKARFLAEAGWRTLLGSKERD----E 457 +++ A +E+ F G+ + + + Sbjct: 380 QRFTASQMTAATLETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGD 439 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E PV+ +G+ L + + TQPP F++ATL+ A+ Sbjct: 440 EEAAGAAPVLEEGEALTLLTVDPKQHFTQPPARFSEATLVKALEEQG------------- 486 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHW 574 +G +T A I + +RG++ K GR + TD G + L + + TA+ Sbjct: 487 ----IGRPSTYAPTIGTIQERGYVNKDGRTLIPTDLGMKVNDQLVQHFPNIVDTEFTANM 542 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ--FRGIVAPGSGGS 625 E+ L ++ + R+ + G + + A R + G Sbjct: 543 EAQLDEVEKGSQRWTQLLADFYGPFVETLKAADEEMKRVVIVTDHLCESCGRP 595 >UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms RepID=C1D174_DEIDV Length = 966 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 149/632 (23%), Positives = 244/632 (38%), Gaps = 89/632 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDSR 57 L I E P+ AR I L K G V IGH+ + + P+ Y Sbjct: 5 LVIVESPAKARTIEKYLGK-------------GYAVESSIGHIRDLPKSASDIPEKYKG- 50 Query: 58 YARWNLADLPIVPEKWQL-QPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W L I + L P + + +++ +A EI+ A D DREG+ + + Sbjct: 51 -KAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIAWHLF 109 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 L+ + V+R + +++ +A++ AI R L + AR D LYG + Sbjct: 110 QELK----PKVPVKRMVFHEITKEAIQAAIAHPRQID--TNLVEAQEARRALDRLYGYEV 163 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 + +L + + LS GRVQ+ ++V R+ E FV+ ++++ T + F Sbjct: 164 S---PVLWKKVAPK--LSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTF 218 Query: 237 TAIWQPSEACEPYQDEEG-------------RLLHRPLAEHVVNRISGQPAIVTSYNDKR 283 A ++ RLL A+ + ++GQ VTS +K Sbjct: 219 PARLTDVGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKP 278 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 ++ PF S LQ E +++ G +A + QKLYE ITY R+D L E Sbjct: 279 FTQRPYAPFITSTLQQEGSRKLGFAATRTMRAAQKLYE-GGYITYMRTDSTNLSVEAVTA 337 Query: 344 RHAVMNAISVHAPDLL-PQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLT 396 + + + P L PQP V +AH AI P T S L Sbjct: 338 ARTQVTQM--YGPAFLHPQPRVYAKKAK-----NAQEAHEAIRPAGSSFRTPDSLRGELG 390 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIE--LDIAKGK---FVAKARFLAEAGWRTLLG 451 +E ++Y+LI ++ + DA R + G+ A R + G+ Sbjct: 391 GDEWRLYDLIWKRTVASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYV 450 Query: 452 SKERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 D E+ TPLP + +G ++ E +TQPP +T+A+L+ A+ Sbjct: 451 EGSDDPNAALEDRDTPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAG--- 507 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA-- 565 +G +T A I+ + RG+ TKKG+ + T A L Sbjct: 508 --------------IGRPSTYASILGTIQDRGYATKKGQALVPTWTAFATSALLEHHFGK 553 Query: 566 -TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L I+ + +++ Sbjct: 554 LVDYDFTARMEEDLDDIAGGRASRVPYLRRFY 585 >UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa RepID=TOP3A_HUMAN Length = 1001 Score = 455 bits (1171), Expect = e-126, Method: Composition-based stats. Identities = 143/672 (21%), Positives = 257/672 (38%), Gaps = 73/672 (10%) Query: 3 LFIAEKPSLARAIADVLPKPH-RKGDGFIECGNGQ-------------VVTWCIGHLLEQ 48 L +AEK A+ IAD+L R+ +G + V+T GHLL Sbjct: 37 LCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAH 96 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDR 106 + ++ +W + P+V + +++ + ++R + +V D DR Sbjct: 97 ----DFQMQFRKWQSCN-PLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDR 151 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + E++ + A + QV R +++ P AV A + L + V V R Sbjct: 152 EGENIGFEIIHVCK-AVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDV--RQ 208 Query: 167 RADWLYGINMTRAYTILGRN----AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFF 222 D G TR T+ + + ++S G Q P LG VV R + I+ FV + F Sbjct: 209 ELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFH 268 Query: 223 EVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYND 281 +K + + + RL + + P A V Sbjct: 269 RIKVT------------HDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRS 316 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K +S+ P L+ A+++ ++A+ + I +KLY T I+YPR++ P + Sbjct: 317 KPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLY-TQGYISYPRTETNIFPRDLN 375 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 V Q +++ +K AH I PT ++ NL +E + Sbjct: 376 LTV-LVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTN--NLQGDEQR 432 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 +Y I R +L DA ++ +E+DIA+ +FVA + + + ++ Sbjct: 433 LYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK--- 489 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 LPV +G E+V+ +T PP+ T+A L++ M G Sbjct: 490 -ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEK-----------------HG 531 Query: 522 LGTEATRAGIIELLFKRGFLTKK-GRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESV 577 +GT+AT A IE + R ++ + G L M ++PD+ A E+ Sbjct: 532 IGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEAD 591 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQ--AKRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 L I + + ++ V Q+ + AK + + A ++ P Sbjct: 592 LKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAM 651 Query: 636 RSA-KKSPPADE 646 +K P ++ Sbjct: 652 PEPIRKCPQCNK 663 >UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota RepID=TOP3B_HUMAN Length = 862 Score = 455 bits (1170), Expect = e-126, Method: Composition-based stats. Identities = 135/632 (21%), Positives = 251/632 (39%), Gaps = 72/632 (11%) Query: 1 MR--LFIAEKPSLARAIADVLPKP----HRKGDG------FIECGNGQVV----TWCIGH 44 M+ L +AEKPSLA++IA +L + H+ +G + GQ V T GH Sbjct: 1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH 60 Query: 45 LLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL---HEASEIVHA 101 ++ + +Y +W+ D + + + + + K LN++K IV Sbjct: 61 VMTL----DFLGKYNKWDKVDPAELFSQAPTEKKEANPK-LNMVKFLQVEGRGCDYIVLW 115 Query: 102 GDPDREGQLLVDEVLD----YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVP 157 D D+EG+ + EVLD + A + V R + + + A+ L Sbjct: 116 LDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEA 175 Query: 158 LCVSALARARADWLYGINMTRAYTILGRNAGYQ---GVLSVGRVQTPVLGLVVRRDEEIE 214 L V A R D G TR T + ++S G QTP LG V R ++I+ Sbjct: 176 LSVDA--RQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQ 233 Query: 215 NFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQP 273 +F + ++ ++A + T D W + R+ R +A+ +N + Sbjct: 234 SFKPETYWVLQAKVNTDKDRSLLLDW-----------DRVRVFDREIAQMFLNMTKLEKE 282 Query: 274 AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDC 333 A V + + K +++ PL + + A+ G+ Q+ + ++LY T I+YPR++ Sbjct: 283 AQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY-TQGYISYPRTET 341 Query: 334 RYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI 393 + PE A + D + + + + R R H I P ++ Sbjct: 342 THYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPR--KGHDAGDHPPITPMKSATEA 399 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK 453 L + ++Y I R ++ D + + I I F + + G+ ++ + Sbjct: 400 ELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQ 459 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 E LP +GD + +++E+QT PP + T+A L++ M Sbjct: 460 SVPLEES---LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEK----------- 505 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKK-GRYIHSTDAGKALFHSL---PEMATRPD 569 G+GT+A+ I + +R ++T + GR + T+ G L H P Sbjct: 506 ------HGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPT 559 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQ 601 + + E L I++ + Y+ + + + Sbjct: 560 IRSAVEKQLNLIAQGKADYRQVLGHTLDVFKR 591 >UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=Q47L55_THEFY Length = 906 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 143/633 (22%), Positives = 241/633 (38%), Gaps = 86/633 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPD-AYDSRYAR 60 +L I E P+ A+ IA L G G +V IGH+ + +RY Sbjct: 22 KLVIVESPAKAKTIAGYL-------------GPGYIVESSIGHIRDLPNKAAEIPARYKD 68 Query: 61 WNLADLPI-VPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A L + V ++ Q+ +K L EA E+ A D DREG+ + + + Sbjct: 69 EPWARLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAIAWHLRE 128 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ V+R + N++ +A+ A R + + L + R D LYG ++ Sbjct: 129 ELK----PTIPVKRMVFNEITKEAIRHAAQHTRDLN--LRLVDAQETRRILDRLYGYEVS 182 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT------P 231 +L + LS GRVQ+ LVV R+ E F +++ +KA Sbjct: 183 ---PVLWKKV--MPSLSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGA 237 Query: 232 ADERFTAIWQPSEACEPYQDEEG------------RLLHRPLAEHVVNRISGQPAIVTSY 279 F A + Q + R L A + R++G V S Sbjct: 238 DPTTFPATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSV 297 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K S PF + LQ EA+++ GLSA+ + + Q+LYE + ITY R+D L E Sbjct: 298 ERKPYRRSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYE-NGYITYMRTDSTTLSES 356 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA----RSSAINL 395 A A + + + + LP + + +AH AI P + L Sbjct: 357 AIAAARAQVARL--YGDNYLPDKPRTYTSKVK----NAQEAHEAIRPAGDTFRTPAETGL 410 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVI-----ELDIAKGKFVAKARFLAEAGWRTLL 450 + E ++Y LI ++ + DAV + + +F A + + G+ Sbjct: 411 SGVELRLYELIWKRTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAY 470 Query: 451 GSKERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 D ++ LP + +GD L + + T+PP +T+A+L+ + Sbjct: 471 VEGTDDPQAELDDRERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELE----- 525 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---E 563 +G +T A II + +RG++ KKG + + A+ L Sbjct: 526 ------------EREIGRPSTYATIIGTILERGYVFKKGSALVPSFLAFAVVQLLERHFS 573 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E VL I+ + +++ Sbjct: 574 HLVDYDFTARMEDVLDAIARGEAERVPWLRRFY 606 >UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1_SYNE7 Length = 883 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 138/665 (20%), Positives = 262/665 (39%), Gaps = 80/665 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQP-DAYDSRYAR 60 +L I E P+ AR I + LPK +R V +GH+ + Q + Sbjct: 3 KLVIVESPTKARTIRNYLPKDYR-------------VEASMGHVRDLPQSASDIPTELKG 49 Query: 61 WNLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 ++L + E K + +K L +A E++ A D DREG+ + +L Sbjct: 50 EKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQ 109 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 LQ R +R + +++ +A++ A+ R + L + R D L G ++ Sbjct: 110 LLQ----PRVPTKRMVFHEITQEAIQAALKNCRDVDQ--RLVHAQETRRILDRLVGYTLS 163 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +L + + LS GRVQ+ + L+V+R+ F ++++KA + A + Sbjct: 164 ---PLLWKKIAWG--LSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEA 218 Query: 238 AIW----QPSEACEPYQDEEGRL--------LHRPLAEHVVNRISGQPAIVTSYNDKRES 285 +W Q + + G++ L + AE + +R+ QP V S +K + Sbjct: 219 KLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTT 278 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 PF+ S LQ E+ ++ LSA+ + + Q LYE ITY R+D +L ++ Sbjct: 279 RKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYE-RGFITYMRTDSVHLSQQAIEAAR 337 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAK 401 + + + + + L +++ +AH AI P L+ E Sbjct: 338 SCVEQM--YGKNYLSPQPRQFTTKSK----NAQEAHEAIRPAGNTFRLPQETGLSGAEFA 391 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--GSKERDE-- 457 +Y+LI ++ + +A + L++ +F A + + G+ GS + D Sbjct: 392 LYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAAL 451 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E+ LP + GD C++ + +TQPP +T+A+L+ + Sbjct: 452 EDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLEN--------------- 496 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHW 574 +G+G +T A II + RG+ + T A+ L + +A Sbjct: 497 --EGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARM 554 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 E L IS + + ++ D+ V+ + P + + + + Sbjct: 555 EQSLDDISNGEVDWLPYLSQFYRG-----DRGLEEQVKLRESEIDPAAARTVALEGLPAK 609 Query: 635 KRSAK 639 R + Sbjct: 610 VRIGR 614 >UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID=D1B6D6_THEAS Length = 708 Score = 452 bits (1162), Expect = e-125, Method: Composition-based stats. Identities = 141/687 (20%), Positives = 260/687 (37%), Gaps = 105/687 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A++++ +L G G V +GH+++ + + Sbjct: 45 LVVVESPTKAKSLSKML-------------GPGYAVEASLGHVMDLPKVRLGVDVENGFE 91 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 PE Q++ + V K+L K AS ++ A DPDREG+ + + L + Sbjct: 92 -------PEYIQVRGKGPVIKRL---KELARGASRVLLASDPDREGEAIAWHLATLLGVP 141 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R I+++ P + A+ + + + AR D L G ++ Sbjct: 142 LDSPC---RVRIHEITPSGISAALQEVEGID--MNKVYAQQARRVLDRLVGYRLSPLLWA 196 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LV R++EI++FV ++++ V+ + Sbjct: 197 KVQRG-----LSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDK 251 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 RL + A V + P V+S+ + PF S LQ EA+ Sbjct: 252 EAGKPV------RLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEAS 305 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G + + I Q L+E LITY R+D + +E + + S Sbjct: 306 RRLGYGPRRTMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHI--ASRF 363 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P LP+ + R DAH AI PT + + L+ + ++Y+LI R+ Sbjct: 364 GPMYLPERPNHFAQKGRS-----QDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRR 418 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 L DA R +E + F + GW + +D E +P ++ Sbjct: 419 ALASQMADARVRTNTLEARCGELTFKCSGVEVTFQGWGAVWPLGVKDTE-----VPAASE 473 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G++L + + ++ TQPP +T+A L+ A+ G+G +T A Sbjct: 474 GEDLRPLQVRLEQKFTQPPGRYTEAGLIKALE-----------------EKGIGRPSTYA 516 Query: 530 GIIELLFKRGFLTK-KGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 I+E L RG++ + + + T G+ + L + D TA E L ++ + Sbjct: 517 TIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLVTHFPDVVQVDFTARMEDQLDRVESGE 576 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAA-------- 632 ++++ + G + + + R + G P G ++ Sbjct: 577 IQWREPIGDFYGPFESRLQEVAASAQRMTVPPELAGEDCPQCGRPLLIRRGRYGEFIGCS 636 Query: 633 -------PRKRSAKKSPPADEVGSGAI 652 +++ P + G G + Sbjct: 637 GYPECDFTKRKETSTGVPCPKCGQGTV 663 >UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F6V0_ACIC5 Length = 878 Score = 451 bits (1161), Expect = e-125, Method: Composition-based stats. Identities = 142/660 (21%), Positives = 246/660 (37%), Gaps = 86/660 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K + V IGH+ + + Sbjct: 5 LVIVESPAKAKTINKYLGKDFQ-------------VEASIGHIKDLPKNKL--------- 42 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D+ + +L P K ++ +++ + I A DPDREG+ + + D L+ Sbjct: 43 GVDVEKGTFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAIAAHLEDELKAV 102 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 +K + ++R N++ P+AV A+D RS L + R D + G ++ Sbjct: 103 VKKPEAIRRITFNEITPKAVTAALDHARSVDR--NLVDAQQTRRVLDRIVGYQISPLLWD 160 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA-DERFTA--I 239 R LS GRVQT L L+V R+++I+ F +++ + A + T + FTA I Sbjct: 161 KVRRG-----LSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEFTAHFI 215 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 E + L + L + VV ++ V K +AP PF+ S LQ Sbjct: 216 GIDGERARVETVDAPALPDQKLTDEVVAQLHKADWSVREVERKERKRNAPAPFTTSKLQQ 275 Query: 300 EAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +A+++ G + + + + Q+LYE LITY R+D + E + Sbjct: 276 DASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEAVRGYIQ--K 333 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 D LP + DAH AI P + + L++ + K+Y LI Sbjct: 334 KVGKDYLPAAPNAFKSKKDA-----QDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRLIW 388 Query: 408 RQYLMQFCPDAVFRKCVIELDIAK---GKFVAKARFLAEAGWRTLLGS----KERDEEND 460 R+++ A+F + +E+ F + G+ + K+ D+E Sbjct: 389 RRFVASQMMPAIFDQTTVEIAARADRRYDFRVTGSVMKFDGFLRVYEEVKEKKDADDEAL 448 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP + GD L + + T+PP + +A+L+ + Sbjct: 449 ANKLPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELE-----------------ER 491 Query: 521 GLGTEATRAGIIELLFKRGFLTKKG---RYIHSTDAGKALFHSLPE---MATRPDMTAHW 574 G+G +T A II + R ++ K G T+ G + L + TA Sbjct: 492 GIGRPSTYATIINTIQDREYVQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARL 551 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP-----VRQFRGIVAPGSGGSADKK 629 E L I + + R+ D + + A + + G K Sbjct: 552 EEELDDIEDGKERWTDLLNGFYDHFEDELKDAATNMEDIKRMEKPTDQKCDICGSPLVLK 611 >UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LVP1_ARATH Length = 926 Score = 451 bits (1160), Expect = e-125, Method: Composition-based stats. Identities = 152/650 (23%), Positives = 263/650 (40%), Gaps = 79/650 (12%) Query: 3 LFIAEKPSLARAIADVLPKP----------HRKGDGFIECGNGQ----VVTWCIGHLLEQ 48 L +AEKPS+A+++A +L + + K F NGQ ++T IGHL+E Sbjct: 12 LNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMEL 71 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN-VIKRFLHEASEIVHAGDPDRE 107 + RY +W+ D + + ++ P K + ++ ++ +V D DRE Sbjct: 72 ----EFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDRE 127 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + EV+D + A + ++R + L + + A+ LR ++ + AR Sbjct: 128 GENIAFEVVDVCR-AVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQL--FAEAVDARQE 184 Query: 168 ADWLYGINMTRAYTILGRNAG--------YQGVLSVGRVQTPVLGLVVRRDEEIENFVAK 219 D G + TR T+L R+ V+S G Q P LG +V R EI+ + Sbjct: 185 IDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPE 244 Query: 220 DFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTS 278 +F+ + Q E + G L A + +P A V + Sbjct: 245 EFWTINCS------------HQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMN 292 Query: 279 YNDKRES-ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 RE + P P + L+ A++ F LS+++ + + ++LY+ I+YPR++ Sbjct: 293 VPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQA-GFISYPRTETDSFS 351 Query: 338 EE----HFAGRHAVMNAISVHAPDLL-PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS- 391 A +A LL P+ + + N DDK AH I PT SS Sbjct: 352 SRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDK---AHPPIHPTKFSSG 408 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 N + + VY L+ R YL AV + +E+DIA +F A R + + + Sbjct: 409 ESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVY- 467 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 R E G+ +PV KG + + + T+PP +A LLS M Sbjct: 468 ---RFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAG------- 517 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM---ATR 567 +GT+AT I+ L RG+ TK T+ G+AL +M + Sbjct: 518 ----------IGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWK 567 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI 617 P++ A E + ++S + + ++ + + A+ + + Sbjct: 568 PNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAM 617 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 146/631 (23%), Positives = 244/631 (38%), Gaps = 84/631 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ IA L G+G V +GH+ + +P + Sbjct: 48 KLVIVESPAKAKTIAQYL-------------GSGYEVQASVGHIRDLIEPKNLPPELKKG 94 Query: 62 NLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 L + E K + +KR L +A E+ A D DREG+ + +L Sbjct: 95 TLGKFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWHLLQV 154 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ + V+R + +++ +A+ERA D R L + R D LYG ++ Sbjct: 155 LK----PKVPVKRMVFHEITKEAIERARDSTRDID--TALVDAQETRRILDRLYGYEVS- 207 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE-RFT 237 +L R G LS GRVQ+ LVV R+ E FV ++++ A + E F Sbjct: 208 --PVLWRKVG--PGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFD 263 Query: 238 AIWQPSEACEPYQ----DEEGRLLHRP--------LAEHVVNRISGQPAIVTSYNDKRES 285 A + D++G L + A R P V S K + Sbjct: 264 ARLVRIDGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYT 323 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 PF+ S LQ EAA++ SA+ + + Q LYE + ITY R+D L ++ Sbjct: 324 RRPAAPFTTSTLQQEAARKLRFSARQTMSVAQSLYE-NGYITYMRTDSPSLSQQAINAAR 382 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLTENE 399 A ++ P+ +P +++ +AH A+ P T + A L N+ Sbjct: 383 K--QAAELYGPETVPDKPRLYAGKSK----NAQEAHEAVRPAGETFRTPQQLASTLRGND 436 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG------KFVAKARFLAEAGWRTLLGSK 453 K+Y+LI ++ + DA + + +F A + G+ Sbjct: 437 HKLYDLIWKRTIASQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEES 496 Query: 454 ERDE-----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 +E E LP + KG +L + +T PP +T+A+L+ + + Sbjct: 497 RDEERHGAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELG---- 552 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR- 567 +G +T A II + RG++T +G + ++ L E T Sbjct: 553 -------------IGRPSTYAAIISTIVDRGYVTPRGTALVPNWIAFSVVRLLEEFFTEL 599 Query: 568 --PDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L +I+E D+++ Sbjct: 600 VQYDFTAGMEDDLDRIAEGAAERVDWLKGFY 630 >UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Group II RepID=A3EPL6_9BACT Length = 850 Score = 450 bits (1157), Expect = e-124, Method: Composition-based stats. Identities = 154/643 (23%), Positives = 254/643 (39%), Gaps = 86/643 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR ++ VL G+G +V +GH+ + SR Sbjct: 52 LIIVESPTKARTLSKVL-------------GSGYLVKASVGHVKDLPP-----SRLGIDV 93 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D + + P K L+ I+ A E+ A DPDREG+ + + L+ Sbjct: 94 DHDF-----ALEFEVHPDKKKVLSEIRSEARSAREVYLASDPDREGEAIAYHIASELEAL 148 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P +R L ++L + A+ V + AR D + G ++ Sbjct: 149 P---VPPKRVLFHELTEGGIRSALSEPGEID--VRKVEAQKARRALDRIVGYTISPLLWD 203 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ + LV R++EI FV ++++ + A P D R + Sbjct: 204 RVRRG-----LSAGRVQSVAVRLVCDREDEIARFVREEYWTIDARF-RPGDPRVPPTFLS 257 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + E+ L A V RI + V + + P + S LQ EAA Sbjct: 258 --RLDRVSGEKPVLPDARTAGQAVERIRRERFTVGEITRADKKRNPSPPLTTSRLQQEAA 315 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 R SA+ + + QKLYE LITY R+D + E A + I H Sbjct: 316 NRLRFSAKKTMTVAQKLYEGVDLPGQGPVGLITYMRTDSVRVSPE---AAEAARSWIRQH 372 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 PD LP P +NR DAH AI P T S ++ + ++Y+LI + Sbjct: 373 HPDGLPARA--PAYKNRK---GIQDAHEAIRPSDVRRTPESLQGSIDPDLFRLYDLIWKS 427 Query: 410 YLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLLG------SKERDEENDGT 462 ++ A++ + + ++ +G F A R L G+ L G + E + Sbjct: 428 FVESQMSPALYLQTTVLVEGDQGDVFRASGRVLKSPGFLALRGLSVAPEDGAGEGEGEDR 487 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + G+ + E+ + T+PP +++A+L+ + G+ Sbjct: 488 LLPPLETGEIVSLEEVTPDQHFTEPPPRYSEASLIRELE-----------------EKGI 530 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA----LFHSLPEMATRPDMTAHWESVL 578 G +T A I+ + R ++ KK + TD GKA L S P+ TA E L Sbjct: 531 GRPSTYATILSTIQDREYVEKKENRFYPTDLGKAVNSLLVESFPD-LMSVRFTARMEEEL 589 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPG 621 Q+ E + Y+D + + +++AK+ + + + P Sbjct: 590 DQVEEGERGYRDVVGDFYTPFHHEVEKAKKGGMTNLKKLEVPT 632 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 163/660 (24%), Positives = 274/660 (41%), Gaps = 69/660 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRK---GDGFIEC---GNGQVVTWCIGHLLEQAQPDAYDS 56 L I EKPS+A+ IA+ L K +K G + E G +V +GHL + + + Sbjct: 8 LIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKE--NK 65 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + + + D+ VP + + V K + +K+ +A E A D D EG+L+ L Sbjct: 66 EFGFYPVFDIKWVPASVD-KGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHAL 124 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y R++ +R + L + + RA + L + +R DW +GIN+ Sbjct: 125 KYCC----GREKAKRMRFSSLTKKEIVRAFENPDEID--YGLVDAGESRHILDWYFGINL 178 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RA R +SVGRVQ P L + R+ EI+ F+ K ++ ++A + Sbjct: 179 SRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALL-------- 230 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLS 295 + E+ + + A++V +I + A V + PF L Sbjct: 231 -------KDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLPPFDLG 283 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQ EA F +S + +I QKLYE + LI+YPR+ + LP++ ++N I H Sbjct: 284 TLQREAYSYFKISPKETQEIAQKLYE-NALISYPRTSSQKLPKDR-KYLEDILNIIKNHP 341 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 + + K+ AH AI +E E ++Y+LIAR+ L F Sbjct: 342 VYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEEL-SEKEKEIYDLIARRTLAAFW 400 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 +A +++DI KF + GW + + DE LP + K D + Sbjct: 401 DNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDE----IELPPLKKNDIIKV 456 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EK + ++TQPP+ +T A+++ + GLGT+ATRA II+ L Sbjct: 457 EKITITRKETQPPKRYTVASIIKELEK-----------------RGLGTKATRAEIIDKL 499 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQDFM 592 KRG++ G + TD G ++ +L MT E L +I ++ + D + Sbjct: 500 IKRGYVIDDG-SLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVL 558 Query: 593 QPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 L +++++ K+ G K + AK + G I Sbjct: 559 DEAEKRLRKILEEFKKKEEDI----------GIYLIKNLDATNKKAKIVGKCPKCGGDLI 608 >UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantarius subsp. infantarius ATCC BAA-102 RepID=B1SE14_9STRE Length = 578 Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 178/623 (28%), Positives = 296/623 (47%), Gaps = 61/623 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHR-KGDGFIEC---GNGQVVTWCIGHLLEQAQPDAYD 55 M+ L +AEKP A+ A+ L P KG ++ V +GHL+E+ P Sbjct: 1 MKYLLLAEKPDQAKKYANALGNPKSDKGVWHVQSSVLNAEVTVAPAVGHLVERINPY--- 57 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 S + W + +LP +PE + +P+ K+ N IK+ + E I+ DPDREG+ + + Sbjct: 58 SNFENWEMTNLPALPEGFSYEPKKDTIKRFNAIKKAVKEVDAIIIGTDPDREGEAIAYRI 117 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 L+ + A +K + R N L + +E+A L++ + V A AR ADWL G N Sbjct: 118 LELIPGALKKIK--YRLWANSLTKKGLEQAYSSLKNPKDSVDYFHEADARGDADWLVGFN 175 Query: 176 MTRAYTILGRNAGY----QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 ++ TI + GY + +SVGRVQTP++ LVVR DE IENF ++++K I Sbjct: 176 LSPFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQLKL-IDPE 234 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 A F + + + AE ++ +++ A+V + + +++ AP Sbjct: 235 AKVTF--------------GNDIKYQSKSEAEQILQQLTN-TAVVKTVTSEEKAQEAPKL 279 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 ++L+ Q E +K + A ++ Q LY+ ++YPR+D + + FA + Sbjct: 280 YNLTNFQSEMSKLYHFDATKTKELVQSLYQ-KGYLSYPRTDSTLITTKEFAYLVDHIEKY 338 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQY 410 L P P R +DKKV H+AIIPT +N L+++E +Y + + Sbjct: 339 QKAINKQLETPNRSP--RKSYVNDKKVVEHYAIIPTETIPDLNELSDDEKLIYQKVVFRT 396 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L+ F PD ++ + LD +F A + GWR K+ D+E LP +G Sbjct: 397 LLMFTPDYRYQSTSVILDNHGLEFKATGAVTKDKGWRNYFSVKKEDKE-----LPHYQEG 451 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 ++ E +V+E T+PP T+ LL K L LGT ATR G Sbjct: 452 QKITVE-CKVLEEVTKPPTRITEQILL----------------KKLLPKYHLGTSATRDG 494 Query: 531 IIELLFKRGFLTKKGR--YIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQ 585 +I+L+ +G++TK + T+ GK L H L ++ T P+ T WE VL QI + + Sbjct: 495 MIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGK 554 Query: 586 CRYQDFMQPLVGTLYQLIDQAKR 608 + + F+ + + + I++ K+ Sbjct: 555 IQKEAFVDKIKWAITKQIEKGKQ 577 >UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYR4_UNCTG Length = 740 Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 128/670 (19%), Positives = 268/670 (40%), Gaps = 80/670 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + I+ +L K V GH+ + + + Sbjct: 5 LVIVESPTKEKTISKILGK-------------DFTVKSSYGHIRDLPKNKLGIDIEDNFK 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + K ++ +K+ + +I A D DREG+ + + + L+L Sbjct: 52 PT----------YKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIAWHLKEALKL- 100 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ R +++ +A+ +A+ R+ + L S AR D L G ++ + Sbjct: 101 --PESKISRITFHEITTEAILKAVKHPRNLD--MKLVNSQQARRILDRLVGYKLS---PL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ + L+ +R+EE ++F+ +++ ++A + +E T Sbjct: 154 LWKKV--KPGLSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELS-KLEENTTPFKSL 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + ++ + ++ ++ + + G IV S K+ S P++ S +Q +A+ Sbjct: 211 LFSKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQDAS 270 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G SA + QKLYE LITY R+D + + + + + Sbjct: 271 RKLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIEY--SY 328 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-----SAINLTENEAKVYNLIARQ 409 + LP+ + + +AH AI P + + L+E+E K+YNLI ++ Sbjct: 329 GSNFLPKIPRIYKTKTK----GAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIWKR 384 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 +L DAV+ E+ F + L G+ + + D+E + LP + Sbjct: 385 FLASQMADAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYNAD--DDEKETKKLPSLKS 442 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G++L + ++ T+PP + A+L+ A+ G+G +T A Sbjct: 443 GEQLNLLRLLPLQHFTEPPPLYDVASLIKALE-----------------EHGIGRPSTYA 485 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 I+ + R ++ G+ T+ G + + L + + TA E L +I+E + Sbjct: 486 PTIKTILDRLYVHLDGKKFVPTNRGIVVNNVLKDHFGNIINVEFTASVEEKLDKIAEDKA 545 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQF-----RGIVAPGSGGSADKKKAAPRKRSAKKS 641 +Q+ ++ + + +A++ +Q + P G + + + + Sbjct: 546 VWQNVLKDFYKPFKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKVQFLGCSG 605 Query: 642 PPADEVGSGA 651 P + Sbjct: 606 YPECKTTLSL 615 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats. Identities = 134/639 (20%), Positives = 252/639 (39%), Gaps = 76/639 (11%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P + G + GH+ + + R Sbjct: 3 KLVIVE-------------SPSKSKSLKKYLGADYDILASYGHVRDL------EPRTGAV 43 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + + + Q K ++ I + +A E++ A DPDREG+ + + + L+ Sbjct: 44 DTENFSM-----KYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAISWHISEILK- 97 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + ++R ++ A++ A+ R + L + AR D+L G N++ Sbjct: 98 EKKVKTPMKRVAFYEITESAIQDAVRNPREIAS--DLVDAQQARRALDYLVGFNLS---P 152 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 +L + LS GRVQ+P L ++V R+EEIE FVA++++ + + FTA Sbjct: 153 LLWKKI--SPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLD-SHKGSQAFTAKLT 209 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + ++ + H ++ + + + A V KR + + PF+ S LQ Sbjct: 210 HFKGEKL---DQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAG 266 Query: 302 AKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G++ V+ Q+LYE LITY R+D L +E + A Sbjct: 267 VRQLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGA--NF 324 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP V + + +AH A+ PT+ + LT+++A++Y L+ ++ Sbjct: 325 DKDYLPPHAVQYKAKTK----NAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKR 380 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 + A F ++ + +G F A + LA AG+ + E DE + LP + + Sbjct: 381 TVACQMTAAQFDTVAADITVGEGTFRATGQTLAFAGFLAVYQDDEDDE--GESKLPALVE 438 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L ++ + TQPP +T+A+L+ A+ +G +T A Sbjct: 439 GETLPVDRLYGEQHFTQPPPRYTEASLVKALEEYG-----------------IGRPSTYA 481 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQISEKQC 586 II L R ++ + + TD G+ + L + D TA E L +S + Sbjct: 482 SIISTLQDREYVVLEKKRFQPTDVGRLVNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKR 541 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGS 625 + + + + P Sbjct: 542 VWSRLLGEFWSGFEGDLKAKQDVERGCPILEACPKCAKP 580 >UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VSX3_NAEGR Length = 1015 Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats. Identities = 134/638 (21%), Positives = 247/638 (38%), Gaps = 79/638 (12%) Query: 3 LFIAEKPSLARAIADVLP-KPHRKGDGFIECGNGQVVTW-------------CIGHLLEQ 48 L +AEKP A+ IA +L ++ +G + + +GHL+E Sbjct: 25 LCVAEKPEAAKQIATILSAGKFQRREGKSKFNKIFEFEYRMNGVVVTMSVTSVLGHLMEL 84 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNV---IKRFLHEASEIVHAGDPD 105 +D + W D + + R K L + +++ A++++ D D Sbjct: 85 ----GFDPKLKSWTSCDPITLMDPATPVFRNVPEKNLEIQQNLEQEARYATKLLLWLDCD 140 Query: 106 REGQLLVDEVLDYLQLAPEK----RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS 161 REG+ + EV++ + + R ++ A+ RAI L + + V Sbjct: 141 REGENIAFEVIEVCKKVNRSLSIENDSILRARFSEFTAAAINRAIRNLERPNVLDSMAVD 200 Query: 162 ALARARADWLYGINMTRAYTILGRNAGYQ---GVLSVGRVQTPVLGLVVRRDEEIENFVA 218 R D G + TR ++ + +S G Q P LG VV+RD I+NF + Sbjct: 201 --TRQELDLRIGASFTRFQSLRLKKKFQGITADYISYGPCQFPTLGFVVKRDLIIKNFES 258 Query: 219 KDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVT 277 + F+ + + + +W + GRL + + Q A V Sbjct: 259 ESFWTLNCTHDMGEEGKAQFLW-----------KRGRLFDQLTCLVIYELCVEAQRARVV 307 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 + KR + P P + LQ A+++ + + + + + LY I+YPR++ Sbjct: 308 NVEKKRRYKYRPDPLNTIELQKLASQKLKMGSHETMKVAESLYN-KGFISYPRTETNNYN 366 Query: 338 EEHFAGRHAVMN------AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS 391 + ++N +A DLL P + DDK AH I P Sbjct: 367 QFQDDDLKRLVNEHTSNPTWGGYASDLLNGGYQKPPSGKQ--DDK---AHPPIHPLKGDC 421 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 N E +Y LIAR +L DAV + + + IA +F + + + + Sbjct: 422 NSN-DSKEQALYELIARHFLACCSKDAVGAETKVIISIANEEFTCSGLMVEQKNFLEIWK 480 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 +++ +PV G E + + +T+PP H +++ L+SAM Sbjct: 481 YDRWSDKS----IPVFNAGQEFIPTSLLMDHGETRPPPHLSESDLISAM----------- 525 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRP 568 ++G+GT+AT A I+ + +RG++ KKG +T+ G AL + P Sbjct: 526 ------DSNGIGTDATVAQHIKTIQERGYVIKKGNRFEATNLGMALLQGYDLIGYELSTP 579 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 ++ + E + IS+ + + + + + Q Sbjct: 580 NLRSKMEKDMLSISKGEQSKEAVIHQSLSMYKHVYIQI 617 >UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_9BACT Length = 897 Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 128/632 (20%), Positives = 233/632 (36%), Gaps = 89/632 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I +L K V GH+ + Q Sbjct: 6 LVIVESPAKAKTIEKILGKDFE-------------VKASFGHVRDLPQRKLGVD------ 46 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P + + Q K + +K I A DPDREG+ + + + L+ Sbjct: 47 ----PDNDFEPEYQVSADKKKVIAELKSSAKNCENIYLAPDPDREGEAIAWHLYEILK-- 100 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + + + +R N++ A++ A D+ + + AR D L G ++ + Sbjct: 101 KQSKAEFKRVTFNEITKSAIKSAFDKAHDVD--MHRVDAQQARRILDRLVGYKVS---PL 155 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + S GRVQT L L+ R++ I F ++++ ++A + A + + I Sbjct: 156 LWK----RNARSAGRVQTVALRLICEREKAIRAFTPEEYWSLQAELKNQAADAQSFI--- 208 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ + + + +V + G V K + PF S LQ A+ Sbjct: 209 -SKLDKIDGKKPHIPNEETSSKIVGELEGSQFRVKDIESKDRKKRPAPPFITSTLQQAAS 267 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S + + QKLYE T LITY R+D + +E +N I + Sbjct: 268 SNLRFSPSRTMSLAQKLYEGRDLGSEGTAGLITYMRTDSVAIAKEAQNAAIDFVNHI--Y 325 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQ 409 + P +N H AI PT + A L ++E K+Y LI ++ Sbjct: 326 GSEFSPDKPNFYKSKN-----SAQGGHEAIRPTDVTRTPKKMAPYLNDDELKLYTLIWKR 380 Query: 410 YLMQFCPDAVFRKCVIEL------DIAKGKFVAKARFLAEAGWRTLLGSKER---DEEND 460 ++ A++R+ I + F L G+ + + D E+ Sbjct: 381 FVASQMVPALYRQDSITFLPENIGMSHEYLFKITGSVLIFDGFMKVYNFSDDGSQDGESK 440 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP + +G+ + + T+PP F++ATL+ + + Sbjct: 441 DVILPQLKEGEICDLLQLIPKQHFTEPPPRFSEATLVKELE-----------------AN 483 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA----LFHSLPEMATRPDMTAHWES 576 G+G +T A II + R ++ K ++ +D G L +LP + TAH E Sbjct: 484 GVGRPSTYASIIRTIQDREYVFKDKGRLNPSDKGMESCDFLITTLPSLF-EVTFTAHMEE 542 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 +L ++ + + ++ AK Sbjct: 543 LLDKVEHGDLEWTKMLGDFYSGFKDWLEDAKT 574 >UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7Q111_ANOGA Length = 1025 Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 137/685 (20%), Positives = 259/685 (37%), Gaps = 87/685 (12%) Query: 1 MR-LFIAEKPSLARAIADVLPKPH-RKGDGFIECGNGQ-------------VVTWCIGHL 45 M+ L +AEK A+ IA +L + ++ +G+ ++T GHL Sbjct: 29 MKYLNVAEKNDAAKTIAGLLSRGSSQRREGYSPYNKIYEFSYNLHGQSIQMIMTSVSGHL 88 Query: 46 LEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL----HEASEIVHA 101 L + + W+ + + R + +Q IK+ L S ++ Sbjct: 89 LTH----EFLPSFRGWHSCSPE---DLFDAPVRKNCPEQYEKIKKTLEREVRGCSALIIW 141 Query: 102 GDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS 161 D DREG+ + E+++ + A + + +V R +++ +++RAI+ L + Sbjct: 142 TDCDREGENIGYEIIEVCR-AVKPQLRVFRAKFSEITAPSIKRAIENLVQPDARQN--DA 198 Query: 162 ALARARADWLYGINMTRAYTILGRNAG----YQGVLSVGRVQTPVLGLVVRRDEEIENFV 217 R+ D G TR T+ + + ++S G Q P LG V +R +EIENF+ Sbjct: 199 VNVRSELDLRIGAAFTRFQTLRLQKSFPQDISNNLVSYGSCQIPTLGFVAQRYKEIENFI 258 Query: 218 AKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIV 276 + F+++K + + RL + E + P A V Sbjct: 259 PQTFWKIKLT------------HTIDDLTVEFHWSRNRLFDKQCCEAYLMLCQTNPTAKV 306 Query: 277 TSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL 336 + K +++ P P L+ +++ ++A+ V+ I +KLY T +I+YPR++ Sbjct: 307 VNVTQKPKNKWRPTPMDTVELEKLGSRKLKMNAKQVMTIAEKLY-TQGIISYPRTETNMF 365 Query: 337 PEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT 396 + V ++ + V+ + R K AH I PT + NL+ Sbjct: 366 TGDM-KLAPLVQAQVASDQWGSFAEKVLQWGVNPR-NGKKSDQAHPPIHPTKLPT--NLS 421 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCV-IELDIAKGKFVAKARFLAEAGWRTLLGSKER 455 +E +VY LIAR +L DA + + + + +F A + E + + Sbjct: 422 GDEWRVYELIARHFLACVSRDATGSETIVNVVVAEEEEFTASGLCIHERNYLEVYPYDRW 481 Query: 456 DEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 + + + G + + E T P T+A L++ M Sbjct: 482 NAKE----IHSYQVGHTFEPTELGLHEGSTTAPNMLTEADLIALMEK------------- 524 Query: 516 LRATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMT 571 G+GT+AT A I + +RG++ + ++ G L M P++ Sbjct: 525 ----HGIGTDATHAEHINTIKERGYIGERDRGFLVPGTLGMGLVEGYEMMELRLAHPELR 580 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQL----------IDQAKRTPVRQFRGIVAPG 621 A E+ L + E + D + + ++ +D+A + Q P Sbjct: 581 AGLEADLKLVCEGRKNPNDVLAEQIAKYKEVYRIMSQKARALDRAMGQRLNQTPQEPPPD 640 Query: 622 SGGSADKKKAAPRKRSAKKSPPADE 646 +G SA + R K P Sbjct: 641 AGASAATATGSAPMREVCKCPKCGH 665 >UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7J0A2_ORYSJ Length = 928 Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 149/683 (21%), Positives = 265/683 (38%), Gaps = 81/683 (11%) Query: 3 LFIAEKPSLARAIADVLPKPH---RKGDG---------FIECGNG----QVVTWCIGHLL 46 L +AEKPS+A+++A++L +P R +G F G +VT GHL+ Sbjct: 13 LNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTGHLM 72 Query: 47 EQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN-VIKRFLHEASEIVHAGDPD 105 E +D R+ RW+ D + + P + + ++ + +V D D Sbjct: 73 EL----EFDDRFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWLDCD 128 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 REG+ + EV+D R + R + L + + A+ L ++ + AR Sbjct: 129 REGENIAYEVIDICA-GANSRLNIWRARFSALIDREIHEAVQHLDRPNKL--FADAVDAR 185 Query: 166 ARADWLYGINMTRAYTILGRNA--------GYQGVLSVGRVQTPVLGLVVRRDEEIENFV 217 D G + TR T+L ++A +LS G Q P LG +V R EI+ Sbjct: 186 QEIDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHE 245 Query: 218 AKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIV 276 ++F+ + E + G L A + +P A V Sbjct: 246 PEEFWTINCS------------HTSDEGTASFGWIRGHLFDYSSAVVIYEMCVEEPMATV 293 Query: 277 TSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL 336 + ++ + + P P S LQ A++ F +S+++ + + ++LY+ I+YPR++ Sbjct: 294 QNVRNQEKLKYPPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQA-GFISYPRTETDNF 352 Query: 337 PEEHFAGRHAVMNAISVHA-PDLLPQPVVDPDIR---NRCWDDKKVDAHHAIIPTARSS- 391 H++++ H Q ++DP+ R N AH I PT S+ Sbjct: 353 SPNT--DLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAG 410 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 N T+N K+Y L+ R +L AV + +E+DIA +F A R + + + Sbjct: 411 ETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVY- 469 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 R + GT LP G + + + T+PP +A LL M Sbjct: 470 ---RFDSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAG------- 519 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM---ATR 567 +GT+AT I+ L R + TK T+ G+AL EM + Sbjct: 520 ----------IGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYDEMGYELWK 569 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSAD 627 P + + E+ + +S + ++ + + A+ V+ F + G+ + Sbjct: 570 PYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAM---GTFFARS 626 Query: 628 KKKAAPRKRSAKKSPPADEVGSG 650 + + S + P Sbjct: 627 SRPVNETQNSIETVRPCAACNES 649 >UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID=C7MGF4_BRAFD Length = 904 Score = 447 bits (1150), Expect = e-124, Method: Composition-based stats. Identities = 136/634 (21%), Positives = 241/634 (38%), Gaps = 85/634 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ AR I L G V +GH+ + P + + Sbjct: 6 HLVIVESPAKARTIGRYL-------------GEEYDVKASVGHIRDIPVPRDLPAEMKKG 52 Query: 62 NLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + E P K + +K+ L +A + A D DREG+ + +L+ Sbjct: 53 PYGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAWHLLET 112 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ P+K V+R + +++ A+ A++ R L + R D L G ++ Sbjct: 113 LK--PKKSLPVKRMVFHEITKDAIRAALENTRDID--ASLVDAQETRRILDRLVGFELS- 167 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE---R 235 +L R + LS GRVQ+ LVV R+ E FVA D++++ + Sbjct: 168 --PVLWRKI--KPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQ 223 Query: 236 FTAIWQPSEACE-------------PYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 FTA + + + +L + +V + PA VT+ K Sbjct: 224 FTAKIATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESK 283 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PF+ S+LQ EA+++ L A+ + + Q LYE + ITY R+D L E Sbjct: 284 PYTRRPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYE-NGYITYMRTDSVTLSGEAI- 341 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLT 396 R + A ++ +P +++ +AH AI P T A L+ Sbjct: 342 -RASRAQAAELYGSQFVPDKPRYYQNKSQA----AQEAHEAIRPAGDHFRTPAEVAGQLS 396 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLG- 451 +E ++Y LI ++ + DA +EL + F A + G+ Sbjct: 397 GDEFRLYELIWKRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEE 456 Query: 452 ------SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 K+ +E+ LP + +G L T PP +T+A+L+ A+ Sbjct: 457 GRDASRYKDDEEKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALED--- 513 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM- 564 G+G +T A + + RG++ ++G + + A+ L E Sbjct: 514 --------------RGIGRPSTYASTVATVQDRGYVLRRGTALVPSWTAFAVVRLLEEHF 559 Query: 565 --ATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L ++++ ++++ Sbjct: 560 GPFIDYDFTAQMEQQLDRMAQGDLARSEYLKNFY 593 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 447 bits (1149), Expect = e-124, Method: Composition-based stats. Identities = 151/630 (23%), Positives = 271/630 (43%), Gaps = 67/630 (10%) Query: 2 RLFIAEKPSLARAIADVLPKPH-----RKGDGFIECGNG---QVVTWCIGHLLEQAQPDA 53 L IAEK + A+ IA +L + + + G V GH+L PD Sbjct: 20 ILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPD- 78 Query: 54 YDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVD 113 ++ RW+L DL + ++ ++ N+++ +A ++ A D DREG+L+ Sbjct: 79 ---KFKRWSLGDLQRLVDEEPIKIIKE-KGIANILRTLAKDADMLIIATDYDREGELIGV 134 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 E L + V+R + L + +E A L + L +A R + D +G Sbjct: 135 ESLSITNF----KGPVKRAKFSALTEREIENAFSNLVDVN--YNLASAAETRQKIDLAWG 188 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 ++TR ++ G + LSVGRVQ+P L L+V+R++EIENFV ++ +K Sbjct: 189 ASLTRFISLASSRRG-KDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFF--KR 245 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPF 292 F+ + + V ++ + A V + + P+PF Sbjct: 246 RNFSGMHISNP-----------FWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPF 294 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 + + EA K G SA + + ++LY I+YPR+D P+ ++++ ++ Sbjct: 295 NTTEFLSEATK-LGFSAAKAMRLAEELY-MGGYISYPRTDNTVYPKT--LSINSILKSLE 350 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 + R K+ H I+PT + NL ++ K+Y L+ R+++ Sbjct: 351 KSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGA---NLEGDKGKIYELVVRRFMA 407 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 D +R+ ++L + F AK + L GW +EE +P++ GDE Sbjct: 408 TLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEK----IPILRIGDE 463 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K E+ ++T+PP +T ++L+ M + LGT++TRA II Sbjct: 464 VKVKKIEIERKETRPPARYTQSSLIREMEKL-----------------NLGTKSTRAEII 506 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQ 589 + LF+RG++ +G I T GKAL SL +PDMTA E + +I + + Sbjct: 507 QKLFERGYV--RGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPE 564 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGIVA 619 ++ L +++ + I + Sbjct: 565 FVVKESREMLKKILSSLEENRSTVGSNIKS 594 >UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1VM20_STRGG Length = 963 Score = 447 bits (1149), Expect = e-124, Method: Composition-based stats. Identities = 142/637 (22%), Positives = 250/637 (39%), Gaps = 94/637 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDS 56 RL I E P+ A+ I L G G VV +GH+ + PD Y Sbjct: 13 RLVIVESPAKAKTIKGYL-------------GPGYVVEASVGHIRDLPNGAAEVPDEYTG 59 Query: 57 RYARWNLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 R + V +Q Q+ +K+ L E+ E+ A D DREG+ + Sbjct: 60 EVRRLGVD----VEHDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWH 115 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + + L+ + V R + +++ A+ A+ R ++ + + R D LYG Sbjct: 116 LQEVLR----PKVPVHRMVFHEITKDAIRAAVANPRELNQ--RMVDAQETRRILDRLYGY 169 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 ++ +L + + LS GRVQ+ LVV R+ E F + +++++ T Sbjct: 170 EVS---PVLWKKVMPK--LSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTG 224 Query: 235 ----------RFTAIWQPSEACEPYQDEEGRL---------LHRPLAEHVVNRISGQPAI 275 R +A+ A +G+L L A + ++ Sbjct: 225 DASDPSNLTARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFT 284 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V S K S PF + LQ EA+++ G A+ + + QKLYE + ITY R+D Sbjct: 285 VRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYE-NGFITYMRTDSTT 343 Query: 336 LPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA----RSS 391 L + A A + + + LP+ + + +AH AI P+ + Sbjct: 344 LSDTAVAAARAQVTQL--YGASYLPEKPRTYAGKVK----NAQEAHEAIRPSGDRFRTPA 397 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIE-----LDIAKGKFVAKARFLAEAGW 446 LT ++ ++Y LI ++ + DA ++ D +F A + + G+ Sbjct: 398 ETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGF 457 Query: 447 RTLL--GSKERDEENDGTP--LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 G+ + + E D LP VA+GD L ++ V T+PP +T+A+L+ + Sbjct: 458 MKAYVEGADDPNAELDDRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELE- 516 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 +G +T A II + RG++ KKG + + A+ + L Sbjct: 517 ----------------EREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLE 560 Query: 563 EMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + D TA E L +IS + + +++ Sbjct: 561 KHFGRLVDYDFTARMEDDLDRISRGEAQSVPWLKRFY 597 >UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms RepID=TOP1_VIBCH Length = 876 Score = 446 bits (1147), Expect = e-123, Method: Composition-based stats. Identities = 135/690 (19%), Positives = 251/690 (36%), Gaps = 102/690 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQ-------------- 48 L I E P+ A+ I L K +V +GH+ + Sbjct: 5 LVIVESPAKAKTINKYLGK-------------DFIVKSSVGHVRDLPTAGQTATPTGKAA 51 Query: 49 ----------AQPDAYDSRYARWNLADLPIVPEK-WQ--LQPRPSVTKQLNVIKRFLHEA 95 + + + + + P WQ Q P K + +++ +A Sbjct: 52 AASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDA 111 Query: 96 SEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEF 155 + A D DREG+ + + + + ++ +R + N++ A+++A + + Sbjct: 112 DSVYLATDLDREGEAIAWHLREIIG---GDEKRYKRVVFNEITKNAIQQAFKQPGELN-- 166 Query: 156 VPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEN 215 + + AR D + G ++ +L + LS GRVQ+ + L+V R+ EI+ Sbjct: 167 MDGVNAQQARRFMDRVVGFMVS---PLLWKKVA--RGLSAGRVQSVAVKLLVEREREIKA 221 Query: 216 FVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI 275 FV ++F+++ A +T + F + + + ++ A V ++ Sbjct: 222 FVPEEFWDINADTLTADKQDFRLLVAQKDGLA------FKPVNETEALAAVAALNKAQYE 275 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V DK + PF S LQ A+ R G + + + Q+LYE ITY R+D Sbjct: 276 VCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEA-GYITYMRTDSTN 334 Query: 336 LPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN- 394 L E + + LP P++ + +AH AI P+ + + Sbjct: 335 LSAEAVENLRGYIT--KHYGEAYLP---SQPNVYGSKQN--AQEAHEAIRPSDVTVTADD 387 Query: 395 ---LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 + + K+Y LI Q++ A + + + A+ AK R L GW + Sbjct: 388 LEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRV-- 445 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 + +N+ LP V GD L + + T+PP +T+A L+ + Sbjct: 446 -QRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEK--------- 495 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---P 568 G+G +T A II + RG++ R + G+ + L E Sbjct: 496 --------RGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNY 547 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK--------RTPVRQFRGIVAP 620 D TA E L QI+E + + + + ++ A+ + I+ P Sbjct: 548 DFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCP 607 Query: 621 GSGGSADKKKAAPRK---RSAKKSPPADEV 647 + A+ S PP + Sbjct: 608 TCSRPMGIRTASTGVFLGCSGYGLPPKERC 637 >UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms RepID=TOP1_STRCO Length = 952 Score = 446 bits (1147), Expect = e-123, Method: Composition-based stats. Identities = 143/636 (22%), Positives = 248/636 (38%), Gaps = 94/636 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDS 56 RL I E P+ A+ I L G G VV +GH+ + P+ Y Sbjct: 13 RLVIVESPAKAKTIKGYL-------------GPGYVVEASVGHIRDLPSGAAEVPEKYTG 59 Query: 57 RYARWNLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 R + V +Q Q+ +K L E+ E+ A D DREG+ + Sbjct: 60 EVRRLGVD----VEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAWH 115 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + + L+ + V+R + +++ A+ A+ R ++ L + R D LYG Sbjct: 116 LQEVLK----PKIPVKRMVFHEITKDAIRAAVANPRELNQK--LVDAQETRRILDRLYGY 169 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV----- 229 ++ +L + + LS GRVQ+ LVV R+ E F + +++++ Sbjct: 170 EVS---PVLWKKVMPR--LSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAG 224 Query: 230 ------------TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVT 277 D R A + ++ + L A + + V Sbjct: 225 DASDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVR 284 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 S K S PF + LQ EA+++ G A++ + + QKLYE + ITY R+D L Sbjct: 285 SVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYE-NGYITYMRTDSTTLS 343 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDK-KVDAHHAIIPTA----RSSA 392 + + A + + + D LP P R K +AH AI P+ + Sbjct: 344 DTAVSAARAQVTQL--YGADYLP-----PQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAE 396 Query: 393 INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIE-----LDIAKGKFVAKARFLAEAGWR 447 LT ++ K+Y LI ++ + DA ++ D +F A + + G+ Sbjct: 397 TGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFL 456 Query: 448 TLL--GSKERDEENDGTP--LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGI 503 G+ + + E D LP VA+GD L E+ V T+PP +T+A+L+ + Sbjct: 457 KAYVEGADDPNAELDDRERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELE-- 514 Query: 504 ARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE 563 +G +T A II + RG++ KKG + + A+ + L + Sbjct: 515 ---------------EREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEK 559 Query: 564 MA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L +I+ + + +++ Sbjct: 560 HFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFY 595 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 154/650 (23%), Positives = 251/650 (38%), Gaps = 89/650 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR+I +L G G V +GH+++ + + Sbjct: 18 LVVVESPAKARSIQKML-------------GPGYEVRASLGHVVDLPERSLGVDVERDFA 64 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + +KR E ++ A DPDREG+ + V L Sbjct: 65 PT----------YEVKKDKKPVVEELKRAA-EGKRLLIATDPDREGEAIGWHVARLLGRD 113 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P ++ R +++ P+ V +A++ R + L + AR D L G N++ ++ Sbjct: 114 P---KEPLRVEFHEITPRVVRQAVEAPRPIDQ--NLVDAQQARRVLDRLLGYNLSPLLSL 168 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE-RFTAIWQ 241 R LS GRVQ+ L LVV R+E IE F ++++ ++ E A Sbjct: 169 EFRKR----ALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLH 224 Query: 242 PSEACEPYQ---DEEGRL--LHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 E + ++EGRL A + + V + ++ P PF+ S Sbjct: 225 EVEGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTST 284 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMN 349 LQ A+ R G +A + I Q+LYE T LITY R+D + E A V+ Sbjct: 285 LQQAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIG 344 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYN 404 P+ LP+ R DAH AI PT L+E E ++Y Sbjct: 345 --KAFGPEYLPEAPRAYKNRREGV----QDAHEAIRPTDPKRTPESVRPYLSEEEYRLYE 398 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERDEENDGT 462 LI R++L DA++ + + L +G+ F A L G+ G +EE Sbjct: 399 LIWRRFLASQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPV 458 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 P V +G E+ R T+PP +TDA+L+ M + + Sbjct: 459 P--AVPEGVPARLEEVLEERRFTEPPPRYTDASLVKTMEELG-----------------I 499 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A +E L KRG++ +KGR + T G+ + L E + TA E L Sbjct: 500 GRPSTYAPTLETLEKRGYVARKGRTLFPTPLGRQVTAYLRERFPQVVAYEFTARMEERLD 559 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKK 629 ++ E + + + + Q + P G + K Sbjct: 560 EVEEGRVPWPKVVWEFYEPFLGELAQVPKK--------TCPRCGRPLELK 601 >UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DDI1_9PROT Length = 725 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 149/668 (22%), Positives = 258/668 (38%), Gaps = 97/668 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E PS AR I + L K V GH+ + + Sbjct: 4 KLIIVESPSKARTIKNFLGK-------------EYEVIASKGHIRDLPKTS--------- 41 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS----EIVHAGDPDREGQLLVDEVLD 117 I E+ + P+ VTK + + L E + I A D DREG+ + + Sbjct: 42 ----FGIKIEEDKFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAH 97 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + P R + +++ A++ A+ R + + AR D + G ++ Sbjct: 98 VIGKDPSSLP---RIVFHEITKTAIKNALKNPRKLD--IDRVNAQQARRLLDRIVGYKLS 152 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 N Q LS GRVQ+ L LVV R+ EI+ F+ K+++ ++ Sbjct: 153 PLL-----NKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNLIK 207 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + E + L R AE +VN + V+ K + +P PF S L Sbjct: 208 YNGKKLEKFD--------LKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTL 259 Query: 298 QIEAAKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q A+ G S + + I QKLYE +ITY R+D + +E + A +N Sbjct: 260 QQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKE---AQEAAINF 316 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNL 405 I + + + +AH AI P T L+++E K+Y+L Sbjct: 317 IKENIGSEYAEAKTYT-----TKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSL 371 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 I ++L DA F I L KG+F + L G+ + G + D T LP Sbjct: 372 IYNRFLASQMKDAKFETQNIYLTNEKGEFKISGKKLIFDGFYKVYGKRGAD-----TLLP 426 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 +G++L E+ + + T+PP +T+A+L+ + + +G Sbjct: 427 EFKEGEKLKPEEIKATQHFTKPPERYTEASLIKKLESLG-----------------IGRP 469 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQIS 582 +T A I LL R ++ K + +H T+ + +L + TA+ E +L +I+ Sbjct: 470 STYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIA 529 Query: 583 EKQCRYQDFMQPLVGTLYQLI----DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSA 638 +Q+ ++ +LI ++ + + G + P G +K + A Sbjct: 530 RGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIA 589 Query: 639 KKSPPADE 646 + P + Sbjct: 590 CSNFPKCK 597 >UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genome shotgun sequence n=3 Tax=Paramecium tetraurelia RepID=A0CUH3_PARTE Length = 947 Score = 445 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 142/626 (22%), Positives = 268/626 (42%), Gaps = 66/626 (10%) Query: 3 LFIAEKPSLARAIADVLPK---------PHRKGDGF-IECGNGQV---VTWCIGHLLEQA 49 L +AEKPS+AR+IA+VL + P+ K F + G+ +V +T GHL Sbjct: 16 LNVAEKPSVARSIANVLARDHTVEETQSPYNKLFKFNFKFGDQEVEMWITSVTGHLKSLR 75 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQL--NVIKRFLHEASEIVHAGDPDRE 107 P +Y +W+ D I+ + +++ K+ +K+F E S+++ D DRE Sbjct: 76 YPK----QYQKWDQWDPIIILKDAEIENIIPNEKRFLEGNLKQFARECSQLILWLDCDRE 131 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + EVL+ + + QV R + + +++A+D L+ E L S LAR Sbjct: 132 GENIAFEVLEVCK-DSNPQIQVHRAHFSAVTYIDIKKALDNLKQPDE--NLSNSVLARQE 188 Query: 168 ADWLYGINMTRAYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 D G + TR T+L + + V+S G Q P LG VV+R +EI++FV + F+ ++ Sbjct: 189 IDLRIGASFTRFQTLLLQQQFHLQSVISYGPCQIPTLGFVVQRQKEIDSFVKEKFWFIQC 248 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 T Y G + + + R + A +T K + Sbjct: 249 EDQTKCG---------------YNWSRGNIFDEMIVLILFERCFTEQAKITDVQSKEVQK 293 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P P S + A+K+ +SA +++ +KLY I+YPR++ P ++ Sbjct: 294 WKPYPLSTIEFEKLASKKLKISAHKAMELAEKLYN-RGFISYPRTETNKFPP-TINLQNI 351 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL-TENEAKVYNL 405 + + ++ Q +++ + +K AH I P + T+ E ++Y L Sbjct: 352 IRDQVNHPVWGEFAQSLINCNFDQPRAGNKDDKAHPPIHPVKMMRESDAQTQQEWEIYQL 411 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 I R +L +A + + L + + F + + E + + +E + +P Sbjct: 412 ITRHFLACCSKNAKGSETTVNLQVQEESFYKQGLVILEKNYLEIYPY----DEWSQSQVP 467 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 KGD + ++ +T PP+ T++ L+ M +G+GT+ Sbjct: 468 NYKKGDMIQIT-LKIQNGKTSPPKPMTESELIGLM-----------------DKNGIGTD 509 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQIS 582 AT I + +R + KKG+ I T G AL S + +P + A E + +++ Sbjct: 510 ATIHEHINTIQEREYAIKKGQIIKPTKLGLALVESYEMLGFTLHKPHLRAVMEQRMNEVA 569 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKR 608 + + + ++ + + ++ Q + Sbjct: 570 QGTKQKKQIVEATIAEMSDILKQLQE 595 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 445 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 142/695 (20%), Positives = 274/695 (39%), Gaps = 104/695 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ L V +GH+ + + Sbjct: 8 LVIVESPAKAKTISKFLDASF-------------FVKSSMGHVRDLPAKKLSVDIENDFT 54 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + PS K + + +AS + A D DREG+ + + L + Sbjct: 55 P----------EYKVIPSREKLIKELISDSKKASTVYLASDLDREGEAIAWHLYKVLDIP 104 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 PEK ++R N++ A++ A + + + + AR D + G ++ + Sbjct: 105 PEK---IRRVTFNEITKDAIQEAFKQYGPIN--MEKVNAQQARRILDRIVGYKIS---PL 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ + L+V R++EI F +++++ A + T + ++ + +P Sbjct: 157 LWKKIAKR--LSAGRVQSVAVRLIVEREKEINEFKPHEYWKITAELKTISGDKKSDDIKP 214 Query: 243 SEAC-EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 +A + +D+ + + A+ + ++ I+T+ + + +AP PF+ S LQ +A Sbjct: 215 FKALLQKLEDKNIEIKNEQQAKEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQQQA 274 Query: 302 AKRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 + R SA+ + I Q+LYE LITY R+D ++ + + S Sbjct: 275 STRLQFSAKKTMLIAQQLYEGIDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIE--SN 332 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIAR 408 + D LP+ + AH A+ P T S LT+++ K+Y LI + Sbjct: 333 YGKDYLPEKPNIYASNKK----GTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWK 388 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 +++ A++ +E+ + F + R L G + G + EE LP + Sbjct: 389 RFVASQMKPALYAITDVEITSNRYIFKTRGRELLFDGHTLISGHEVDREE---QILPPLE 445 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 K L + + TQPP +++A+L+ + + +G +T Sbjct: 446 KDHVLELIQLLPTQHFTQPPPRYSEASLVKTLEKMG-----------------IGRPSTY 488 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A II + RG++ ++ R ++T+ G + L E + T+H E L +I EK+ Sbjct: 489 ATIISTIQDRGYVKQEKRAFYATELGILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKK 548 Query: 586 CRYQDFMQPLVGTLYQLIDQA----------------------KRTPVRQFRGIVAPGSG 623 + ++ +++A K +R R G Sbjct: 549 IDWLTVLKEFYEPFKIDLEKAIGEMKSVKGTPEESDRICNLCSKPMVIRWGRHGKFFGCS 608 Query: 624 GSADKKKAAPRKRSAKKSPP------ADEVGSGAI 652 + K P + +PP ++ GS I Sbjct: 609 AFPECKNTMPLDEKGEAAPPETSDQACEKCGSPMI 643 >UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA) III alpha n=3 Tax=Neoptera RepID=UPI0000DB782E Length = 958 Score = 445 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 143/631 (22%), Positives = 257/631 (40%), Gaps = 78/631 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKG-------------DGFIECGNGQ-VVTWCIGHLLEQ 48 L +AEK A+ IA L + K + ++ N ++T GHLL Sbjct: 4 LNVAEKNDAAKNIAAYLSRGTYKRREGLWLYNKIFEFNSYLWNKNCHMIMTSVSGHLLNC 63 Query: 49 AQPDAYDSRYARW------NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAG 102 + Y +W +L D P+V + Q S K +++ + + + ++ Sbjct: 64 ----EFVGIYRKWQSCHPLSLFDAPVVKQCSQ----ESSIKIKKTLEKEVQKCNALIIWT 115 Query: 103 DPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSA 162 D DREG+ + E++ + A + ++ R +++ +V R++ L + + V Sbjct: 116 DCDREGENIGFEIIQVCR-AIKPNIRIYRAKFSEITQTSVNRSLQNLCEPDKAISDAVDV 174 Query: 163 LARARADWLYGINMTRAYTILGRNAG----YQGVLSVGRVQTPVLGLVVRRDEEIENFVA 218 R+ D G TR T+ R ++S G Q P LG VV R IE F Sbjct: 175 --RSELDLRIGAAFTRFQTLRLRKVFPTTLADMLISYGSCQFPTLGFVVERFLAIEEFKI 232 Query: 219 KDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVT 277 + ++++K + ++ E G+L + E ++ QP A V Sbjct: 233 EPYWKIKVMDIRDNISV------------EFKWERGKLFEKLPCEIFLDICLEQPNATVQ 280 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 + K S+ PLP L+ + +++ L+A+ ++ I +KLY T LI+YPR++ P Sbjct: 281 KISSKPTSKWRPLPLDTIELEKQGSRKLNLNAKEIMRIAEKLY-TQGLISYPRTETNIFP 339 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE 397 +E V I+ A Q +++ + R K AH I P NL Sbjct: 340 KE-LNLISLVNQQINNPAWGNFAQQLLEKGVNPRK-GKKSDQAHPPIHPIKYCD--NLNG 395 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE 457 NEAKVY + R +L +A+ + ++E+DIA KF A + E + + E Sbjct: 396 NEAKVYEFVVRHFLACLSSNAIGHQVIVEIDIAGEKFNANGLQVIEKNYLDVYIY----E 451 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 + + + +G E++E +T PP+ T+A L++ M Sbjct: 452 KWNEQKIHNYREGQVFKPTSIEMIEEKTSPPQLLTEADLITLM----------------- 494 Query: 518 ATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAH 573 G+GT+AT A I+ + R ++ +Y+ G L M ++P + A Sbjct: 495 DKHGIGTDATHAEHIDTIKSRQYVGLVDEKYLIPGKLGIGLVLGYDNMGFQMSKPGLRAE 554 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLID 604 E L I E++ ++ ++ + L Sbjct: 555 LERDLKLICEQRKNAKEVLENQINKYRDLFK 585 >UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepID=D1B572_SULD5 Length = 694 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 134/668 (20%), Positives = 249/668 (37%), Gaps = 86/668 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I + L K V GH+ + ++ + Sbjct: 8 LIIVESPTKAKTIKNFLGK-------------NYTVVASKGHIRDL-PKSSFGIK----- 48 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +PE + + IK EA ++ A D DREG+ + + + Sbjct: 49 IDNQTFIPE---YRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFHIATAIGKD 105 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P + + R + +++ A+ A++ R E + AR D + G ++ + Sbjct: 106 P---KSLPRIVFHEITKNAITHALENPRILDE--SSINAQQARRLLDRIVGYKLSPLLS- 159 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + Q LS GRVQ+ L +VV R++EI F ++F+ + A I Sbjct: 160 ----SKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFN-------KTIEAS 208 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E + E+ + ++ A + ++ + V K S F S LQ A+ Sbjct: 209 LVEFEGEKIEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSAS 268 Query: 303 KRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G S + + + Q LYE +ITY R+D + +E +S + Sbjct: 269 SALGYSPKKTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAARE--QILSQYG 326 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQY 410 LP+ +++ +AH AI PT ++ L +E K+Y LI ++ Sbjct: 327 KTYLPEKARFYANKSK----GAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRF 382 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L +A F + + GKF A R L G+ + G ++D+ LP +A Sbjct: 383 LASQMNNARFESQTLIFESQSGKFKASGRKLLFDGFYKVYGDNDKDK-----LLPDLALK 437 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 E+ K + + T+PP +++A+L+ + + +G +T A Sbjct: 438 QEVTLSKLDANQHFTEPPSRYSEASLIKKLESLG-----------------IGRPSTYAP 480 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 I +L R ++ + + I T+ + L + T+ E L I+E + Sbjct: 481 TISVLSARDYINIEKKQIVPTEVAFQVTELLEQHFPQIVDSSFTSTMEERLDLIAEDKED 540 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQ----FRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 +Q + + + K Q F G + P G ++K + A + P Sbjct: 541 WQAILWNFYEPFDAQVAKGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYP 600 Query: 644 ADEVGSGA 651 + Sbjct: 601 TCKYTQNL 608 >UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium RepID=Q33E26_ENTFC Length = 787 Score = 444 bits (1142), Expect = e-123, Method: Composition-based stats. Identities = 146/624 (23%), Positives = 267/624 (42%), Gaps = 43/624 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAYD-- 55 + +AEKP A L +VTW IGHL+ + P+ Y+ Sbjct: 4 VILAEKPDQGAKFASALAGKKLSKKSGKYEFKSEIFGDTIVTWGIGHLVGLSLPEKYEWL 63 Query: 56 SRYARWNLADLPIVPEK--WQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVD 113 +W+L +LP +P+ + + +Q +++K L A EI+ A DPDREG+ + Sbjct: 64 PNKDKWHLDNLPFLPKFNELKYEVSKGKNQQFSIVKSCLENADEIIIATDPDREGENIAY 123 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 + + + ++R IN L + + + LR++ E + A AR AD+L G Sbjct: 124 NIFKLCK-QSIFNKPIKRLWINSLVQKEIIKGFKNLRNSEETISYFKEANARQIADYLVG 182 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 +N T Y++ + G GV+S+GRVQTPV LVV D I+NF + + ++ H Sbjct: 183 MNYTELYSLKLQEKGISGVVSLGRVQTPVNTLVVENDLAIKNFRPEKYKTIECHTTDKQP 242 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 + E ++++ + S I+ ++ FS Sbjct: 243 KAIFKNSLEYFKLEKFEEDTKKFGLD----------SASTGIIKKIEVSKKQTEPQKLFS 292 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L +Q A K++ SA+ I Q LY+ ++YPR+D + F A ++ Sbjct: 293 LGGIQEYANKKWKYSAKKTDKIIQSLYD-RGYLSYPRTDSELITTNEFEYLKANLDVYKS 351 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLM 412 + P ++P + R D+ KV H+A+IPT I NLT +E +Y ++ R+ + Sbjct: 352 VLGISIDTPCLEP--KKRFVDNDKVLEHYALIPTMDIPDIANLTLDEKNIYEIVTRRACL 409 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F + + LD+ +F GW+ + + + ++ + T LP + + Sbjct: 410 MFAEPYKYENTKVTLDVNGLEFTTSGNVPISLGWKQVDTNLDESDDKEET-LPKFHEQET 468 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +++ T+ P+ T+ LL K + A GLGT ATR+ I+ Sbjct: 469 INI-DIRFIDKLTKEPKRLTEGKLLG--------------KTGIMAKLGLGTPATRSNIV 513 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQ 589 + L R ++ + ++ T G L+ + +P+ TA WE L +I++ + Sbjct: 514 DTLLNREYIKIENTNVYPTPKGYLLWDLTKNKDLLIGKPENTAIWEESLGKIAQGNYTQE 573 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQ 613 F++ + + + + K+ Sbjct: 574 AFLRNIYNYINKTVSDLKKVEFTS 597 >UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YKX8_THEYD Length = 777 Score = 444 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 137/676 (20%), Positives = 253/676 (37%), Gaps = 85/676 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I ++ K + V IGH+ + + D + Sbjct: 8 LIIVESPAKAKTINKIVGKDFQ-------------VKASIGHIKDLPE-DRLGVDIEKGF 53 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D I+P K + +K A +I A DPDREG+ + + + +++ Sbjct: 54 QPDYIIIP---------GKEKIVKELKDSAKNAQKIFIATDPDREGEAIAYHIAEEIKVP 104 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K V R + +++ P AV+ AI + S AR D L G N++ Sbjct: 105 ENK---VYRAIFHEITPNAVKAAIANPSKID--INKVYSQQARRILDRLVGYNLSPF--- 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP---ADERFTAI 239 L + + LS GRVQ+ L +VV R++EI F ++++ + + + R Sbjct: 157 LWKKV--KKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLY 214 Query: 240 WQPSEACEPYQDEEGRLL--HRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + ++E+ + L A+ ++ + I+T K++ ++ P PF + L Sbjct: 215 KYKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATL 274 Query: 298 QIEAAKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q +A+ G S + + + Q+LYE LITY R+D + EE ++ Sbjct: 275 QAQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIE- 333 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNL 405 + + + + + DAH I PT S LT+ + +Y L Sbjct: 334 -KNFGKEFVGNHKIHETKKQKT---PIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKL 389 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 I ++L A + ++ +F + G+ + + +E + T Sbjct: 390 IWDRFLASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIY---KDEESEEDTV 446 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + L + E + T+PP +T+ATL+ A+ G+G Sbjct: 447 LPQLNEKTSLKISELEAQKHTTEPPPRYTEATLVKALE-----------------EKGIG 489 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQ 580 +T A I+ + +RG++ K + + T G + L E TA E L + Sbjct: 490 RPSTYATILSTIQERGYVKKVKQKLQPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDK 549 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRT-----PVRQFRGIVAPGSGGSADKKKAAPRK 635 IS + ++ ++ +DQA + P G + + Sbjct: 550 ISLNEAKWNKVIEEFYKEFENDLDQASKISKVIKPKEIKTSFKCEKCGKDMVIRWSKGVP 609 Query: 636 RSAKKSPPADEVGSGA 651 A P + Sbjct: 610 FLACSGYPECKNTRSL 625 >UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepID=B8DVL2_BIFA0 Length = 986 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 131/631 (20%), Positives = 233/631 (36%), Gaps = 84/631 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I L G+G V +GH+ + AQP + Sbjct: 6 KLVIVESPAKAKKIGGYL-------------GDGYTVLASVGHIRDLAQPSQVPADEKAK 52 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ P K ++ ++ L ASE+ A D DREG+ + ++ L Sbjct: 53 FGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAWHLVQTL 112 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + +++ P+A+ +++ R + + R D LYG ++ Sbjct: 113 K----PKVPVKRMVFHEITPEAIRASLEHTREVDN--NMVDAQETRRVLDRLYGYELS-- 164 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA------- 232 +L R G LS GRVQ+ L+V R+ E FV +++V A + P Sbjct: 165 -PVLWRKVG--PGLSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTD 221 Query: 233 -DERFTAIWQPSEACEPYQDEEGRLLH-----------RPLAEHVVNRISGQPAIVTSYN 280 + R A+ A +G L A + + ++ V S Sbjct: 222 FESRMIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVE 281 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S +Q A R G+S++ + Q LYE + ITY R+D L E Sbjct: 282 KKPYRRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYE-NGYITYMRTDSVTLSHEA 340 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINL 395 ++ L + + +AH I P S L Sbjct: 341 IEAARESVS--KNFGSQYLSEKPKQYATKT----AGAQEAHECIRPAGSHFRDPSQLATL 394 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI-----AKGKFVAKARFLAEAGWRTLL 450 ++ K+Y LI ++ L DA + F + + G+ + Sbjct: 395 PPDQLKLYTLIWQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVT 454 Query: 451 GSK--ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 G + + + LP +A+ EL + +TQPP +T+A+L+ + Sbjct: 455 GERGGSGKKGEESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLE------- 507 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--- 565 +G +T A II + RG++ ++GR + + A+ L Sbjct: 508 ----------AKEIGRPSTYANIISTIIDRGYVYERGRALIPSWLAFAVTRLLETKFPKY 557 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 TA E+ L QI+ ++++ Sbjct: 558 VDYQFTADMENGLDQIAHGNETGREWLTQFY 588 >UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QYG0_BRAHW Length = 716 Score = 443 bits (1140), Expect = e-122, Method: Composition-based stats. Identities = 138/669 (20%), Positives = 249/669 (37%), Gaps = 84/669 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G+ +V +GHL++ R Sbjct: 28 LVIVESPAKAKTINRYL-------------GSDYLVMSSMGHLIDL-------PRSRLAI 67 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D PE ++ R K LN +K+ +A E++ A D DREG+ + + + ++ Sbjct: 68 DVDHGFEPEYITIRGRA---KILNELKKEAKKAEEVLLAADDDREGESIAWHIGNKIR-G 123 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R + +++ A++ AID+ R + + AR D L G N++ Sbjct: 124 VNSAVPIKRIVFHEITKDALKEAIDQPRDID--ISKVNAQKARRVLDRLIGYNLSPLLWD 181 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ L ++ R++EIE FV +++ + ++ F A Q Sbjct: 182 KIKRG-----LSAGRVQNVALLIICNREDEIETFVPVEYWT-FGVFLKHKNKEFLAELQ- 234 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+ E+ L + E ++ + + V S K + P++ S LQ A+ Sbjct: 235 -----KYKGEKPDLKTKQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAAS 289 Query: 303 KRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G SA + + Q LY E LITY R+D + + + Sbjct: 290 SALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIE--KEYG 347 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-----SSAINLTENEAKVYNLIARQY 410 + LP P+ DAH AI PT S L ++ K+Y LI ++ Sbjct: 348 SNYLP-----PEPPTYSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERF 402 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + A + + +F + + G+ +L + D+E + +P ++K Sbjct: 403 VSSQMLPAKMKNTRAIIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEK-ASKMPNLSKD 461 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + + T PP +TDA+L+ + +G +T A Sbjct: 462 DVCEFVENNPQQHFTTPPPRYTDASLVKILEESG-----------------IGRPSTYAP 504 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCR 587 I+ + R ++ +KG+ + T+ GK + + E + TA ES L +I + Sbjct: 505 TIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIE 564 Query: 588 YQDFMQPLVGTLYQLIDQAKRTP------VRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 + + ++ + A + V G K+ A Sbjct: 565 WNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSG 624 Query: 642 PPADEVGSG 650 P + G Sbjct: 625 FPECKNTKG 633 >UniRef50_C7X7R3 DNA topoisomerase I (Fragment) n=7 Tax=Bacteroidales RepID=C7X7R3_9PORP Length = 653 Score = 443 bits (1139), Expect = e-122, Method: Composition-based stats. Identities = 174/602 (28%), Positives = 269/602 (44%), Gaps = 44/602 (7%) Query: 41 CIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIK 89 GHLL QA P AY AR LP++P ++L R P +QL V++ Sbjct: 1 TYGHLLAQAPPSAYG--LARVERQALPLIPVPFRLVVRQVRTEQGYVTDPVAIRQLEVLR 58 Query: 90 RFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRL 149 L A +V A D REG+L+ +LDYL R+ R I+ L +A+ L Sbjct: 59 GLLENADALVIATDAGREGELVSRYLLDYLG----YRKPALRLWISSLTEKAILNGFKNL 114 Query: 150 RSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRR 209 R + +F L ++A AR ADW+ G+N + I A G S+GRVQTP L LV RR Sbjct: 115 REDGDFDNLALAARARREADWILGVNAS----ITLGIAAGMGNHSLGRVQTPTLALVCRR 170 Query: 210 DEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI 269 E +FV F ++ + + R + AE R+ Sbjct: 171 YLENRDFVPVSCFHLQTGVCKYGQ-------------KVLFTCPLRYERKEDAEKARARL 217 Query: 270 SGQP-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITY 328 G+ V + K E PLP L+ LQ EA R G++A L + Q+LYE ++Y Sbjct: 218 EGKGRCTVLAVEKKEVMEQPPLPHDLTGLQREANTRLGMTAGQTLAVVQRLYE-RGCVSY 276 Query: 329 PRSDCRYLPEEHFAGRHAVMNAISVHAPD-LLPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 PR+ CR++PE+ F ++ + H + +++ + D+ V HHA++ T Sbjct: 277 PRTGCRHIPEDIFKQAPTLVATLKGHPHFGRHAERLLEKGLNPHAVDESSVAGHHALLIT 336 Query: 388 ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWR 447 L+ +E +Y+LIA + L F V ++ D +F A+ + GWR Sbjct: 337 GEMPE-GLSPDEQNIYSLIAGRMLEAFSEGCVREVIRVKADYGGMEFEAETSCVKYPGWR 395 Query: 448 TLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 + + EE TPLP +G+ L + E++E T+P FT+A LL+AM Sbjct: 396 DIYNGPDMAEE--STPLPQFHQGETLAVLETEILEDSTKPLPPFTEAGLLAAMENAGGT- 452 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMAT 566 D + KK + GLGT TRAGII+LL R ++ + G + T+ G ++ + ++ Sbjct: 453 ADGESKKKITERCGLGTPGTRAGIIDLLVARRYVERIGNRLIPTEKGLEIYGIVGDKLIA 512 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ--FRGIVAPGSGG 624 MT WE L +I E + FM+ + +++ + VR P G Sbjct: 513 DAAMTTAWEEALREIEEGRLSAGKFMKGVHEYARKIVSELLALQVRNPGVTRCACPKCGT 572 Query: 625 SA 626 Sbjct: 573 GT 574 >UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola AmH RepID=B9L7D9_NAUPA Length = 728 Score = 443 bits (1139), Expect = e-122, Method: Composition-based stats. Identities = 139/663 (20%), Positives = 254/663 (38%), Gaps = 89/663 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I + L K V GH+ + + + + Sbjct: 5 LIIVESPAKARTIKNFLGK-------------EYEVVASKGHIRDLPKTS-FGIKIEEDK 50 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q + +K +A I A D DREG+ + + + Sbjct: 51 FIP--------QYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKK 102 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 PE ++ R + +++ A+++A++ R+ + + AR D + G ++ Sbjct: 103 PE---ELPRIVFHEITKTAIKKALENPRTID--LNRVNAQQARRLLDRIVGYKLSPLL-- 155 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 N Q LS GRVQ+ L LVV R+ EI+ F ++++ ++ F I Sbjct: 156 ---NKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEG--------IFKKIEGS 204 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ + + A+ +V + V K + +P PF S LQ A+ Sbjct: 205 LIKYNGKKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVAS 264 Query: 303 KRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G S + + I QKLYE +ITY R+D + +E + A + I + Sbjct: 265 SELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKE---AQQAALEFIKQNI 321 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQY 410 + Q + +AH AI P T L +E K+Y LI ++ Sbjct: 322 GEEYAQAKTYA-----TKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRF 376 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L DA F I + KG+F R L G+ + G + + T LP KG Sbjct: 377 LASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYG-----KPSANTLLPEFEKG 431 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 ++L E + + T+PP +T+A+L+ + + +G +T A Sbjct: 432 EKLKPEDVKATQHFTKPPERYTEASLIKKLESLG-----------------IGRPSTYAP 474 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 I LL R ++ K + +H T+ ++ +L + + TA+ E +L +++E + Sbjct: 475 TITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKD 534 Query: 588 YQDFMQPLVGTLYQLID----QAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 +Q+ ++ +L++ + + + P G +K + A S P Sbjct: 535 WQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYP 594 Query: 644 ADE 646 + Sbjct: 595 KCK 597 >UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei RepID=Q83FM2_TROWT Length = 841 Score = 443 bits (1139), Expect = e-122, Method: Composition-based stats. Identities = 141/659 (21%), Positives = 259/659 (39%), Gaps = 84/659 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ ++ L G+G VV +GH+ + P R Sbjct: 3 KLVIVESPTKVSSVGRYL-------------GDGYVVMSSVGHIRDLPAPSGLTPDLKRS 49 Query: 62 NLADLPI-VPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 A + + ++ + K + ++ L+ + E++ A D DREG+ + ++ Sbjct: 50 AHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWHLVQV 109 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ V+R + +++ +A+ A+ R E L + AR D LYG ++ Sbjct: 110 LK----PTVPVRRLVFHEITREAIAYALQHPRPIDE--NLVDAQEARRILDRLYGYELS- 162 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD----- 233 +L + + LS GRVQ+P L+V R+ E NF + ++ V A +D Sbjct: 163 --PVLWKKV--RPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDSDVFSAS 218 Query: 234 -----ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI-VTSYNDKRESES 287 ER A + + + + +L + L + ++ + + A+ V + + K S + Sbjct: 219 LTLFGERKIATGRDFDNLANLK-TDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRN 277 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PF S LQ +AA + G SA+ + Q+LYE ITY R+D L + + A Sbjct: 278 PYAPFITSTLQQDAAHKLGFSAKRTMRTAQQLYE-KGFITYMRTDSPRLSLQAISAARAQ 336 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA------RSSAINLTENEAK 401 + + + + LP D +AH AI PT S L+ + + Sbjct: 337 VELL--YGREFLP----DSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMR 390 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDI---AKGKFVAKARFLAEAGWRTLLGSKERDEE 458 +Y+LI R+ + A + L + FV L E G+ + E ++ Sbjct: 391 LYDLIWRRTIASQMVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVY---EGLQD 447 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + LP + GD++ V T PP +T+A+L+ + + Sbjct: 448 LNSKLLPNLQVGDQVTLVDVRAVGHTTLPPPRYTEASLVKVLEELG-------------- 493 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWE 575 LG +T A I+ + +RG+ + R + ++ + L + D TA+ E Sbjct: 494 ---LGRPSTYALILSTIQERGYAHLRNRMLVPDWLAFSVVNLLENFFSRLIDYDFTANLE 550 Query: 576 SVLTQISEKQCRYQDFMQPLV------GTLYQLIDQAKRTPVRQFRGIVAPGSGGSADK 628 L +I+ D+++ L ++I AK R I G+ + Sbjct: 551 DQLDEIALGSQNRSDWLRKFYFGDDNLPGLKEIISGAKDIDARAINSIPMVGATLRVGR 609 >UniRef50_B4U9A2 DNA topoisomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U9A2_HYDS0 Length = 775 Score = 442 bits (1138), Expect = e-122, Method: Composition-based stats. Identities = 181/695 (26%), Positives = 307/695 (44%), Gaps = 116/695 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRK---GDGFIECG-NGQVVTWCIGHLLEQAQPDAYDSR 57 RL +AEKPS+AR IA L K K G+ EC +TW IGHL+E A Sbjct: 3 RLILAEKPSVARDIASALCKSLNKDASKKGYFECEEKNLYITWAIGHLVEIDDEIAP--- 59 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +W+L LPI+PE ++ + + Q VI + L E E+V A D REG+L+ +L Sbjct: 60 -RKWSLETLPILPETFKYKVIDKTSNQFKVISKLLKEVDEVVIATDAGREGELIARLIL- 117 Query: 118 YLQLAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + + V+R +D L + + R ++ L+ S F L SALAR+ ADW+ GIN+ Sbjct: 118 ---MLNHFKGSVKRFWTSDALTKEVIIREMENLKDASLFDSLYYSALARSHADWIVGINL 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV--TPADE 234 TR T+ GV SVGRVQTP L L+V R +E ++F+ K+++ +KA + Sbjct: 175 TRLMTV----KAGGGVWSVGRVQTPTLKLIVDRYKEFKDFIPKEYYVIKAVFSACDDCID 230 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG----------------------- 271 + + + Q++ + L L E + +G Sbjct: 231 TISKSYVGLLVLDKAQEKTYKTLKDALEEEESEKTAGAPKSKYFTPLLKESKNQIMEKLE 290 Query: 272 --QPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 + IV + E+ PL SL++LQ EA + +G S+ L+I QKLYE++K ++YP Sbjct: 291 KVKEGIVKDVKITKRKENPPLLHSLTSLQREANRIYGYSSMRTLNIAQKLYESYKCLSYP 350 Query: 330 RSDCRYLPEEHFAG---RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP 386 R+D YL E+ ++ + + + + L + + + R +D K+ HHA+IP Sbjct: 351 RTDSNYLGEDQETKNLVKNLLKKLVDKNIYEFLSKNINK--VGKRVFDSSKLTDHHALIP 408 Query: 387 TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLA---- 442 + + E +YNL+ R+++ F + I+ + + F++ Sbjct: 409 FGPIPE-DASNEEKNIYNLVFRRFVGAFMEPYEYAIITIKTMLGEFTFISNINIETLTEE 467 Query: 443 --EAGWRTLLGSKERD------EENDGTP------------------------------- 463 + + +L + + E+ D P Sbjct: 468 EYQKTYLSLYRPYKLEIKESLSEDEDIEPNNIERYQRVSELRNRRSHQGEERNAYSTLDF 527 Query: 464 --LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 + + D++ E +++ T+PP +T+ TLL M + Sbjct: 528 DYIKSLKPDDKVYKRSLEALQKFTKPPALYTEGTLLKVMEKLG----------------- 570 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQ 580 LGT ATRA IIE L +R ++++ + + T G+ L SL ++P+MT WE L + Sbjct: 571 LGTPATRASIIETLLERKYISRVDKSLLPTLKGEELIKSLRDSDVSKPEMTTTWEEELER 630 Query: 581 ISEKQCRYQ---DFMQPLVGTLYQLIDQAKRTPVR 612 I +++ + FM + + ID+ K ++ Sbjct: 631 IYKERKSKEGYIRFMHNIKEFVSDNIDRLKFVEMK 665 >UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_PELUB Length = 863 Score = 442 bits (1137), Expect = e-122, Method: Composition-based stats. Identities = 134/642 (20%), Positives = 243/642 (37%), Gaps = 76/642 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L + E P+ A+ I L G+ +V GH+ + + Sbjct: 1 MNLVVVESPAKAKTINKYL-------------GDDYIVLASYGHIRDLPSKNGSVDPENN 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + K L I +S+I+ A DPDREG+ + V +YL Sbjct: 48 FKMEW----------EVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVKEYLN 97 Query: 121 LAP-EKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 K + ++R + N++ +AV I+ R L + +AR D+L G N++ Sbjct: 98 EKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPL--LVDAYMARRALDYLVGFNISPI 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 G S GRVQ+ L L+ R+ EIE F ++F+ + +I Sbjct: 156 LWTKL-----PGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSDK---NSI 207 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + E+ ++ + + + + + + K + + PF+ S LQ Sbjct: 208 LASITQLNDKKIEKFSFKNKAEIDKAMEEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 ++ R G A + I QKLY ET LITY R+D L + + + Sbjct: 268 VSSGRLGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIK--N 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + +P + +AH AI PT A + L+ ++ K+Y+LI Sbjct: 326 EFGDEYVPDNAASYSGKKAK---NAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIW 382 Query: 408 RQYLMQFCPDAVFRK--CVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 + L A F + I D A + G+ ++ ++D +D LP Sbjct: 383 SRALSSQMKPAQFDRNTITISSDDNGTICKASGSVIKFDGFLKVMKDTKKD--DDEDILP 440 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 + KG + E + TQPP +++A+L+ + + +G Sbjct: 441 EMNKG-PVNIESLLDEQHFTQPPPRYSEASLVKKLEELG-----------------IGRP 482 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQIS 582 +T A II ++ RG+ + H TD GK + L ++ ++ + TA E+ L I+ Sbjct: 483 STYASIISVISTRGYAETINKRFHPTDRGKLISAFLEKLFSKYVDYNFTASLENQLDDIT 542 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGG 624 + + ++ Q + K R+ ++ G Sbjct: 543 TGKEGWIKVLELFWKDFNQNVSDVKEKRTREVLDLLNDSLGS 584 >UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepID=B6KEM8_TOXGO Length = 677 Score = 442 bits (1136), Expect = e-122, Method: Composition-based stats. Identities = 149/688 (21%), Positives = 248/688 (36%), Gaps = 78/688 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQ-------------VVTWCIGHLLEQA 49 L +AEKPS+A+ + +L ++ + T GHL+ Sbjct: 9 LNVAEKPSVAKEASRLLSGGYQNAPTQSRFNPVHQFEFSLQNRSCTMLFTSVRGHLMSL- 67 Query: 50 QPDAYDSRYARWNL---ADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDR 106 + S Y WN DL P + + + + +A +V D DR Sbjct: 68 ---DFASAYQNWNTIPPEDLYGAPVEKNISQDAGDVR--KNLVDLARKAQWLVLWLDCDR 122 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + EVL + A V R + + L +ERA L++ + R+ Sbjct: 123 EGENIAFEVLSVCREA-NASLNVFRAVFSALTKADLERACRTLQAPDR--NQSDAVDTRS 179 Query: 167 RADWLYGINMTRAYTILGRN--AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 D G + TR T+ R+ +S G Q+P LG VV R E+ENFV + ++ + Sbjct: 180 EIDLRIGASFTRFLTMRYRSRVKLPSPTISYGPCQSPTLGFVVSRFVEVENFVREAYWTI 239 Query: 225 KAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKR 283 + I P DE+ + E RL + + A VT Sbjct: 240 RVTISKPDDEKGA---NAPPLSIDFTWERQRLFDQLAVLVLYEMCLENPEATVTDVRGTE 296 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 ++ P+P L A+++ +S+ + I + LY+ +I+YPR++ Sbjct: 297 RTKQRPVPLCTVELHKMASRKLRMSSARCMSIAESLYQ-RGIISYPRTETEVFSPTM-DL 354 Query: 344 RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVY 403 + I A Q +VD D + AH I P L E E K+Y Sbjct: 355 LSLIRVHIGSTAWGTYAQKLVDGDFLWPSDGARDDKAHPPIHPLKLMQRSELEEEEWKLY 414 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 + R +L DA + +E+DIA F A + E W + E+ G Sbjct: 415 EFVTRHFLACCSEDAFGFETRVEIDIAGEGFYATGLTVLERRWLDVYPY----EQWSGNR 470 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + ++ + ERQT+PP T+A L+ M +G+G Sbjct: 471 LPRFLVNERVMPSSILMSERQTEPPPLLTEADLIDLM-----------------DKNGIG 513 Query: 524 TEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM-------ATRPDMTAHWE 575 T+AT I + R + K TD G AL+ + + PD+ A E Sbjct: 514 TDATMHDHIRTIQDRHYCYKNENMQFVPTDLGVALYQGFKRLAEVSGVDLSLPDLRARME 573 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR------TPVRQFRGIVAPGSGG----- 624 + + ++ Q+ + V + ++ K T +R G + G Sbjct: 574 ADMALVARGAKTKQEVLDLHVSEMKRVFLLLKSHAAHMDTEMRNRLGGLEDSVGRDGVTL 633 Query: 625 -----SADKKKAAPRKRSAKKSPPADEV 647 K +A + ++ PA Sbjct: 634 VANFSECGKCRAPMDLKVSENCEPAQHC 661 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 441 bits (1135), Expect = e-122, Method: Composition-based stats. Identities = 156/661 (23%), Positives = 276/661 (41%), Gaps = 75/661 (11%) Query: 1 MR-LFIAEKPSLARAIADVL-PKPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPD 52 M + I EKP + IA L P +K G +E + +GHL Sbjct: 8 MHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQ 67 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 + + + DL P + + V LNVI++F A +HA D D EG L+ Sbjct: 68 SNEE-----HFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIG 122 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 L Y E ++ R + L + ++RA S AR D+++ Sbjct: 123 FNALKY-GCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVD--YGQVDSGAARHILDFIF 179 Query: 173 GINMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N++R+ + A + + LS GRVQTP L ++V R++EI +F ++ ++A + Sbjct: 180 GVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELG-- 237 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 + + G++ R L + ++ + G A V + P+P Sbjct: 238 -------------EGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVP 284 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F L LQ EA + FG S + I Q LY T +YPR+ + LPE G ++ + Sbjct: 285 FDLGTLQSEAYRVFGFSPKKTQTIAQNLY-TEGYTSYPRTSSQKLPESI--GYEKILKNL 341 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 + + + + ++ K+ DAH AI PT + L+++E KVY+LI +++ Sbjct: 342 AKNPRFGVHIERLRGPLKPHE-GKKEDDAHPAIHPTGLLPS-ELSKDEKKVYDLIVHRFI 399 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F DA+ + +EL+I + +F + +++AGW + ++E P ++ GD Sbjct: 400 SVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEE----FPEISGGD 455 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 L ER+T+PP + +A+L+ + GLGT++TRA I Sbjct: 456 SLAVRSVSADERETKPPARYNEASLIRELER-----------------RGLGTKSTRADI 498 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCRY 588 I L+ R ++ +G+ I + G+ + +L E ++T +E L I + Sbjct: 499 IAKLYDRKYI--EGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISK 556 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGI-----------VAPGSGGSADKKKAAPRKRS 637 + + + ++ + + + P GG K +PR RS Sbjct: 557 DRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIK-YSPRNRS 615 Query: 638 A 638 Sbjct: 616 T 616 >UniRef50_D0NZ98 DNA topoisomerase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NZ98_PHYIN Length = 907 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 141/681 (20%), Positives = 252/681 (37%), Gaps = 80/681 (11%) Query: 1 MR-LFIAEKPSLARAIADVL--PKPHRKGDGFIECGN--------------GQVVTWCIG 43 M+ L +AEKPS+A+ IA++L + HR N VVT G Sbjct: 1 MKVLNVAEKPSVAKEIANILSSGRSHRVCRAGFSKYNALFEFPYQVRGQQVQMVVTSVTG 60 Query: 44 HLLEQAQPDAYDSRYARWNLAD---LPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVH 100 H++E +D+ W+ D L P +++ + K + + +V Sbjct: 61 HIMEL----DFDASVRSWHSCDPVDLFTAPVTKKIRSDETQKKIEKTLMEEAKHSQWLVL 116 Query: 101 AGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCV 160 D DREG+ + EV + R +V R + L P+ + A+ L +E + L V Sbjct: 117 WLDCDREGENIAYEVKSICEKT-NSRLRVFRARFSALIPRDIVHAVQNLSQPNEKLSLAV 175 Query: 161 SALARARADWLYGINMTRAYTILGRNAG-----YQGVLSVGRVQTPVLGLVVRRDEEIEN 215 A R+ D G TR T+ ++ + V+S G Q P LG VV R +I N Sbjct: 176 DA--RSEIDLRIGAAFTRFQTMRIQSRFPALNQEKNVISYGPCQFPTLGFVVERFLKIRN 233 Query: 216 FVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPA 274 F + F+ + QP ++ + G R + + Q A Sbjct: 234 FEREAFYYISVTHQQTD--------QPDAPTTTFKWKRGHFFDRMACLCIYESLVESQTA 285 Query: 275 IVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCR 334 + S + + + PLP + LQ A++ +S++ + + LY LI+YPR++ Sbjct: 286 AIESVDKRPSWKRKPLPLTTVELQKRASRWLRISSEATMKAAESLYN-KGLISYPRTETS 344 Query: 335 YLPEEHFAGRHAVMNAISVHAPDLLPQPVVD-PDIRNRCWDDKKVDAHHAIIPTARSSAI 393 E + + + + ++D + AH I PT Sbjct: 345 KFKEGTDLMSLVRAHETHQQWGNYVTRQLLDGGKYEAPRHGNSDDQAHPPIHPTKSVDLN 404 Query: 394 NLTE-NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS 452 L + +E KVY ++ +L DA + + + + +F+A + E + + Sbjct: 405 TLPDPDEKKVYEFVSLHFLACCSRDAKGSQTSVVMAMLNERFIASGLMVEERNYLDIYKY 464 Query: 453 KERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDL 512 E+ + + +PV GD ++ T PP ++A L++ M Sbjct: 465 ----EKWNASAIPVYKHGDVFRPSTLVMLSGDTNPPPLLSEADLIAKM------------ 508 Query: 513 KKILRATDGLGTEATRAGIIELLFKRGFLTKKGR--YIHSTDAGKALFHSLPEM---ATR 567 ++G+GT+AT A I+ + KR + K T G AL S M + Sbjct: 509 -----DSNGIGTDATIAEHIKTILKREYAIKVNNETQFKPTTLGLALVLSYEHMGLELAK 563 Query: 568 PDMTA----HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV------RQFRGI 617 P + A E+ IS Q + + + + + + R+ + G Sbjct: 564 PVLRAAVSLIMENDCKAISLGQKALRQVVDSCMAQMKGIFLEVTRSATVLDQTFSEQFGQ 623 Query: 618 VAPGSGGSADKKKAAPRKRSA 638 + + R R+ Sbjct: 624 PVYDTADFRMPPRGEARPRTP 644 >UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1_FRASC Length = 1049 Score = 440 bits (1131), Expect = e-121, Method: Composition-based stats. Identities = 144/658 (21%), Positives = 241/658 (36%), Gaps = 111/658 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS---RY 58 RL I E P+ A+ IA L G G V IGH+ + + A + Sbjct: 81 RLVIVESPAKAKTIAGYL-------------GPGWQVESSIGHIRDLPRSAADVPAAHKG 127 Query: 59 ARWNLADLPIVPEKWQLQ-PRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W + + + L P Q++ +K + +ASE+ A D DREG+ + +L Sbjct: 128 KPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAWHLLQ 187 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ V+R + +++ PQA++RA+D R + L + R D LYG ++ Sbjct: 188 TLK----PTVPVKRMVFHEITPQAIQRAVDNPRDIDK--NLVNAQETRRILDRLYGYEVS 241 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI--------- 228 +L + + LS GRVQ+ ++V R+ F + +++ ++ Sbjct: 242 ---PVLWKKVMPR--LSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAW 296 Query: 229 -------------------------VTPADERFTAIWQPSEACEPYQDEEGRL------- 256 TP A+ A G+L Sbjct: 297 SGADGTPGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTR 356 Query: 257 LHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDIC 316 L A + R++ V S K S PF S LQ EA ++ S+Q + + Sbjct: 357 LDEATARSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVA 416 Query: 317 QKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDK 376 Q+LYE + ITY R+D L + A ++ + P+ +P P + + Sbjct: 417 QRLYE-NGYITYMRTDSTNLSKTALTAARAQAASL--YGPEYVP---ARPRTYAKKVKN- 469 Query: 377 KVDAHHAIIP------TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVI----- 425 +AH AI P T L + ++Y LI ++ + DA I Sbjct: 470 AQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGAT 529 Query: 426 ELDIAKGKFVAKARFLAEAGWRTLL--GSKERDEENDGTP--LPVVAKGDELLCEKGEVV 481 +F A + + G+ G+ + D E + LP V +GD L Sbjct: 530 SSAGEDAEFSASGKVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPR 589 Query: 482 ERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL 541 T PP FT+A+L+ + + +G +T A II + RG++ Sbjct: 590 GHTTSPPARFTEASLVKTLEELG-----------------IGRPSTYASIIGTIQDRGYV 632 Query: 542 TKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 KKG + + A+ L + T TA E L I+ D++ Sbjct: 633 WKKGSALVPSFVAFAVVGLLEDHFTRLVDYRFTATMEDDLDDIAAGTAASTDWLTRFY 690 >UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax=Chlamydiales RepID=Q256J1_CHLFF Length = 862 Score = 440 bits (1131), Expect = e-121, Method: Composition-based stats. Identities = 138/654 (21%), Positives = 245/654 (37%), Gaps = 88/654 (13%) Query: 1 MR--LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 M+ L + E P+ + + +L K G + +GH+++ + Sbjct: 1 MKKSLIVVESPAKIKTLQKLLGK-------------GFIFASSLGHVVDLPA-KTFGIDI 46 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 D I+P+ + +N I + + + DPDREG+ + + + Sbjct: 47 EHDFEPDYQILPD---------KQEVINQICKLASSCDVVYLSPDPDREGEAIAWHIANQ 97 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L K Q+QR N + AV A+ R + L + AR D + G ++ Sbjct: 98 L----PKNTQIQRVSFNAITKGAVNEALKHPREID--MALVNAQQARRLLDRIVGYKIS- 150 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER-FT 237 IL R + +S GRVQ+ L LVV R++ IE FV +++ ++ + P + F Sbjct: 151 --PILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFW 208 Query: 238 A--------IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 A W+ +DE + A+H + VT K + +A Sbjct: 209 AHLYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAA 268 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHF 341 PF S LQ EA++ F S+ + + Q LYE LITY R+D + E Sbjct: 269 PPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEA- 327 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LT 396 +N + + D Q + DAH AI PT + + LT Sbjct: 328 ------LNNVRDYIQDTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLT 381 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIA-KGKFVAKARFLAEAGWRTLLGSKER 455 ++ +Y+LI ++++ A++ + + K A L G+ + K Sbjct: 382 NDQHMLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKID 441 Query: 456 DE--ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 D+ E + LP + D L EK + T+P FT+A+L+ + Sbjct: 442 DDVAEEENPSLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEKSG--------- 492 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDM 570 +G +T A I+ + R + K+ + + T+ GK + L Sbjct: 493 --------IGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGF 544 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGIVAPGS 622 TA E L I++ + ++ ++ ++ A++ V R I Sbjct: 545 TALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVVTDIDCSAC 598 >UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Entamoeba RepID=B0EMC7_ENTDI Length = 607 Score = 440 bits (1131), Expect = e-121, Method: Composition-based stats. Identities = 141/640 (22%), Positives = 247/640 (38%), Gaps = 66/640 (10%) Query: 3 LFIAEKPSLARAIADVLPKPH-------RKGDGFIECGNG--------QVVTWCIGHLLE 47 L +AEKPS+A AI+ L + K + E VT GHL Sbjct: 5 LHVAEKPSVANAISYTLSRGQCQKTSGLSKYNSIFEFEKEFKNIGKCTHYVTSVAGHLKG 64 Query: 48 QAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN-VIKRFLHEASEIVHAGDPDR 106 + + Y W D + + P+ K++ +K + +V D DR Sbjct: 65 I----DFTTAYRSWGSCDPEELFTAPIEKSVPASMKKVELNLKNVAKKCQVLVLWLDCDR 120 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + EV++ + +V R N L P + +A + L + + + + R Sbjct: 121 EGENISFEVIEVCSEV-NSKMKVWRAHFNSLVPDEIIKAYNTLTAPNRH--MSEAVDVRQ 177 Query: 167 RADWLYGINMTRAYTILGRNAGY---QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 D G TR T L +N VLS G Q P LG VV R +I+ F + F++ Sbjct: 178 EIDLRTGAAFTRFQTTLLKNKSKALEGKVLSYGACQFPTLGFVVDRYYQIKAFTKETFYK 237 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYND 281 + + + + + RL R + + + A +T + Sbjct: 238 INCVVE------------KNSILTEFHWDRNRLFDRLICDLLYEDALEHINSATITEILE 285 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K + PLP + LQ +K F +S+ + I +KLY + LI+YPR++ P + Sbjct: 286 KSRTNFKPLPLTTVDLQKACSKYFKISSNETMTIAEKLYNS-GLISYPRTETNIFPSDM- 343 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 + Q +++ I+N +H I PT ++ +L+E E K Sbjct: 344 DHEKQIKMFQENRIYSSYVQELLNGKIKNPRNGKATDKSHPPIHPTRNANLNDLSEKERK 403 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 +Y+ I R YL DA + I L + F + E + + ++ ++ Sbjct: 404 IYDFIVRNYLANMSDDARGFETKIGLQVGNESFHCNGLMITERNYLNIFPFRKWSDKE-- 461 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 +P +G+++ EV +T PP+ T+ L+ M +G Sbjct: 462 --IPEFHEGEKVQLNCFEVSYGETSPPKPLTEPELIQLM-----------------DKNG 502 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVL 578 +GT+AT A I+ + +R ++ K T+ G AL M +RP + A E L Sbjct: 503 IGTDATIAQHIQKIQEREYVIVKQGSFIPTNLGLALVEGYDSMGFEFSRPQLRAETEKEL 562 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 T+I + D + + +L ++A+ + I Sbjct: 563 TKICSGESNKDDVISTFIEQYEELYERAQYNKSKLVNAIK 602 >UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HWV0_9BACT Length = 865 Score = 439 bits (1130), Expect = e-121, Method: Composition-based stats. Identities = 139/665 (20%), Positives = 254/665 (38%), Gaps = 99/665 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR + +L +R V +GHL + + Sbjct: 50 LIVVESPTKARTLTRILGPDYR-------------VKASVGHLKDLPASRIGVDVDRDYE 96 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L + + K L+ I++ A EI A DPDREG+ + + L Sbjct: 97 L----------EFEVSEGKKKVLDEIRQAARGAREIYLASDPDREGEAIAYHIASEL--- 143 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ ++R L+++L P+ + +A++ + + AR D + G +++ Sbjct: 144 SSLKKPIRRVLVHELTPRGIAQALEHPGEID--LHKVDAQKARRALDRIVGYSLSPLLWE 201 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ + LV R+ EI FV +++ + R T ++ Sbjct: 202 RVRRG-----LSAGRVQSVAVRLVCDRENEINAFVPVEYWTILQTFHPTESGRETDAFEA 256 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + E+ + + A+ V+ R+SG+ + S + + P + S LQ E A Sbjct: 257 --KLDRIAGEKAEIGSQQEAQAVLERLSGENFRIGSVSADEKKRQPSPPLTTSRLQQEGA 314 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +RF A+ + + QKLYE LITY R+D L E + I + Sbjct: 315 RRFRFPAKKTMQVAQKLYEGVEIPGQGLTGLITYMRTDSVRLAPEAQEMAR---DYIRRN 371 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P LP P RN+ DAH AI PT + L + +VY LI + Sbjct: 372 YPQGLPSK--SPSYRNKK---GIQDAHEAIRPTDVNRTPESLASVLDRDLLRVYQLIWQS 426 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEENDGT------ 462 ++ A + + + ++ + F A R + + G+ + G++ + Sbjct: 427 FVESQMLPARYLQTTVIVEGDQADSFRATGRRMLDPGFLAVRGARGKGAARSAKNEEEED 486 Query: 463 -------PLPVVAKGDELLCEK-GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 LP++ +G+ ++ + + TQPP + +A+L+ + Sbjct: 487 GTDEEEAELPLLHEGESVVALGPPDASQHFTQPPPRYNEASLIRELE------------- 533 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAG----KALFHSLPEMATRPDM 570 G+G +T A I+ + R ++ K+ + T+ G + L S P++ Sbjct: 534 ----EKGIGRPSTYATIMTTILDREYVEKRENRFYPTELGQTVNRLLVDSFPDLL-NVAF 588 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGG 624 TA E L + E Y++ + + +AK + + I P G Sbjct: 589 TARMEEELDAVEEGDKVYREAVDDFYRPFSAELGRAKGGGMTNLKAKSEPTDIPCPVCGT 648 Query: 625 SADKK 629 KK Sbjct: 649 LMVKK 653 >UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y390_9BACT Length = 767 Score = 439 bits (1129), Expect = e-121, Method: Composition-based stats. Identities = 146/657 (22%), Positives = 257/657 (39%), Gaps = 90/657 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A+ + +L G+G VV +GH+++ + SR A Sbjct: 74 LVVVESPTKAKTLTKIL-------------GSGYVVKASVGHIVDLPK-----SRLAIDI 115 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 D PE ++ + V K+L A +I+ A DPDREG+ + V + L + Sbjct: 116 ENDFK--PEYILVKGKAPVKKELQA---AAATAQKILLAADPDREGEAIAWHVAELLGVD 170 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P++ R +++ AV A+ + + AR D L G ++ + Sbjct: 171 PKENC---RVRFHEITADAVRNAVKEPAPID--MDRVDAQQARRVLDRLVGYTLS---PL 222 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 L + + LS GRVQ+ L ++ R++EIENFV +D++ V + + Sbjct: 223 LWKKI--RRGLSAGRVQSVALAILCEREQEIENFVPQDYWNVFVDATADDGRAYRLHVER 280 Query: 243 SEACEPYQDEEGRLLH-RPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 D + + + + +P IV S+ K+ + P PF S +Q A Sbjct: 281 ENGRSLLSDGKTLAIDTLAKVRDIEKTLKEKPLIVASFTAKKNARKQPAPFKTSTMQQIA 340 Query: 302 AKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 A R G S + + I Q L+E T L+TY R+D + E + V+ Sbjct: 341 ASRLGFSPRRTMGIAQSLFEGVAIPGHGTVGLVTYMRTDSLRMAPEALSQARKVIE--GR 398 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIAR 408 LP V DAH AI PT S +LT + ++Y++I R Sbjct: 399 WGKKYLPAKAVVYQA-----GANAQDAHEAIRPTDFALTPESIRESLTAEQYRLYDMIWR 453 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + AV ++ + K A+ + GW + +D + Sbjct: 454 RSVASQMAPAVVDSATLDCECGKYGLRAQGASVGFDGWGAVWDLDVKDA-----MIQKAR 508 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L + + QT+PP FT++TL+ + DG+G +T Sbjct: 509 EGELLNIRNVQSEKEQTKPPARFTESTLIKTLED-----------------DGIGRPSTY 551 Query: 529 AGIIELLFKRGFLTK-KGRYIHSTDAGKALFHSLPEMA--------TRPDMTAHWESVLT 579 A I+E L+ R ++ + +GR + ++ G+++ L E T+ ES L Sbjct: 552 ATIVETLYDRSYVAREEGRKLKPSELGRSVNKFLLEHFDGKSTSPIVDVGFTSSMESSLD 611 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRT-----PVRQFRGIVAPGSGGSADKKKA 631 Q+ + + + + I +A++ P + G P G KK+ Sbjct: 612 QVESGKKNWVELIGQFWKPFTDAIAEAEKAPVVPPPPPELTGETCPQCGRPLVKKQG 668 >UniRef50_B6A9W0 DNA topoisomerase n=2 Tax=Eimeriorina RepID=B6A9W0_9CRYT Length = 843 Score = 439 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 134/658 (20%), Positives = 240/658 (36%), Gaps = 87/658 (13%) Query: 3 LFIAEKPSLARAIA----------DVLPKPHRK----GDGFIECGN--GQVVTWCIGHLL 46 L IAEK S+A+ IA + L + + G+ +VT GH+ Sbjct: 56 LCIAEKHSVAKEIAWCLCPQNQNPNYLNSKSKTNPVLSFPYYFEGSKCNMIVTSVRGHIK 115 Query: 47 EQAQPDAYDSRYARWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGD 103 + +D R++ W D ++ +K + AS ++ D Sbjct: 116 QL----KFDPRFSSWETVDPIVLLNLSTPLIKVVSEDCNDIAQNLKHYSKLASTLILWLD 171 Query: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 DREG+ + EV+ L + ++ R + L +E A++ L + + + + Sbjct: 172 CDREGENIAFEVISVC-LDANPKLKILRARFSALTKSDIEGAMNNLVAPNR--AMSDAVE 228 Query: 164 ARARADWLYGINMTRAYTILGRNAGY--QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF 221 AR D G + TR T+ + + LS G Q P LG VV R +I +F ++ F Sbjct: 229 ARQEIDLRIGSSFTRFLTLRYQKLFPIPESTLSYGPCQFPTLGFVVDRYRKIVSFKSEPF 288 Query: 222 FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYN 280 +++ + +++ + + R+ A + P A V S + Sbjct: 289 WQISVTLSFHSEDG-----SLKDKLIKFDWIRDRIFDHLAALVIYEFCLEDPIATVVSVH 343 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K+ PLP + + A+ + + ++I + LY+ I+YPR++ PE Sbjct: 344 GKQVRNYKPLPMNTVEMTKIASIKLNIPPITTMNIAENLYQ-KGYISYPRTETNSFPESM 402 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE-NE 399 + + N + ++H I P T E Sbjct: 403 DLKVIIREQINHQTWGRYASLLISNDKYCNPRCGNSSDESHPPIHPVKCLDQNEATSAEE 462 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 K+Y LI R +L DA+ ++ V+ LDIA +F AK + E W + ER Sbjct: 463 WKLYELITRHFLAVCSDDAIGQESVVILDIAGEQFKAKGLVVLEENWLDIYKPYER---W 519 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 G LP +GD+L + + +T+PP T+A L+ M Sbjct: 520 CGNVLPEFNQGDKLTPYSIFLSQSKTEPPHLITEAELIDLM-----------------DK 562 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM-------------- 564 +G+GT+AT IE + R ++ K R + T G AL E+ Sbjct: 563 NGIGTDATMHEHIEKIQTRQYVIKNPRSQLIPTSLGYALALGFEEISKEANKIEQRDGLL 622 Query: 565 ----------------ATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA 606 RP++ + E + +IS + ++ ++ + Sbjct: 623 LASDSSRNSICKFDKNLIRPNLRSAMEFSMKEISGGILNRSTVVAEILDSMKYIYQTM 680 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 438 bits (1127), Expect = e-121, Method: Composition-based stats. Identities = 165/629 (26%), Positives = 261/629 (41%), Gaps = 69/629 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTW----CI-----GHLLEQAQP 51 MRL I+EK + AR IA L + K +G TW C+ GH+L P Sbjct: 1 MRLIISEKANAARKIAQFLAEGPVK-EGKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYP 59 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 + Y + W D P ++ S ++ +A ++ A D DREG+L+ Sbjct: 60 EEY----SNWQKVD-PRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELI 114 Query: 112 VDEVLDY-LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADW 170 E L + P V+R + L V RA + L S L + AR D Sbjct: 115 GVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSR--ELADAGEARQDIDL 172 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 ++G +TR + + G LSVGRVQ+P L L+ R+ E FV + ++EV+A + Sbjct: 173 IWGATLTRWVSRAVKRYG-SAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQN 231 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 F A GR A + +S + A+VT + + AP Sbjct: 232 GG-GPFVARH-----------ARGRFKEEAEARRALENLS-ETAVVTEVRQREATRPAPA 278 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE----HFAGRHA 346 PF+ +A AA G+S I + LY T I+YPR+D PE G A Sbjct: 279 PFNTTAFLTAAAN-IGVSPSRAARIAEDLY-TEGYISYPRTDNTVYPESLDLREVLGFLA 336 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLI 406 + + +A LL + P R + H I PT R+S L E++ K+Y L+ Sbjct: 337 EVEGVGDYAGRLLGAGRLTPTRGRR-----QTTDHPPIYPTGRASRAELREDQWKIYQLV 391 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 R++L A + + + VA + E GW + R +E LP Sbjct: 392 VRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE----LPR 447 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +++GDE+ + E++ ++TQPP + L+ M + LGT+A Sbjct: 448 LSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLMEDLG-----------------LGTKA 490 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISE 583 TR GII+ L+ RG++ G I T+ G A+ +L + +MTA E + ISE Sbjct: 491 TRPGIIQNLYDRGYIH--GDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISE 548 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 + ++ L ++ D + + + Sbjct: 549 GRVSKDSVVEESRELLRRVYDHLESSEEK 577 >UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FRC6_SORC5 Length = 864 Score = 438 bits (1126), Expect = e-121, Method: Composition-based stats. Identities = 141/701 (20%), Positives = 259/701 (36%), Gaps = 139/701 (19%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L GNG V GH+ + P ++ + + Sbjct: 5 LVIVESPAKAKTIKKYL-------------GNGYEVFASKGHVKDL--PKKQNAVDVQND 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 A+ + K L +K +A E++ A DPDREG+ + + + ++ Sbjct: 50 FAE--------TYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIK-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + +V R +++ + V+ + R E L + AR D + G +++ + Sbjct: 100 -NPKLKVARVEFHEITKKGVDHGVHNPRKLDE--NLYDAQRARRVLDRIVGYDVS---AL 153 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---VTPADERFTAI 239 + + LS GRVQ+ L L+V R+ E+E FV ++++ + + P F A Sbjct: 154 VWSKLAFG--LSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAK 211 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ ++ + + +A V + V + + + P P++ S LQ Sbjct: 212 LASADG------KKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQ 265 Query: 300 EAAKRFGLSAQNVLDICQKLYET---------HKLITYPRSDCRYLPEEHFAGRHAVMNA 350 +A A+ + I Q LYE LITY R+D + ++ A V+ Sbjct: 266 DATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVV-- 323 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKK--VDAHHAIIPTARSSAIN-----LTENEAKVY 403 + + +P+ R + KK DAH AI PT+ + L + + K+Y Sbjct: 324 AKRYGKEFVPE-------RPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLY 376 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIAK---------GKFVAKARFLAEAGWRTLLGSKE 454 LI +++ AV+ + +E+D+A A R L AGW + ++ Sbjct: 377 KLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQ 436 Query: 455 R------------------------------------DEENDGTPLPVVAKGDELLCE-- 476 EE+ LP + +G+ L Sbjct: 437 EFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPP 496 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 ++ TQPP + + +L+ + G+G +T A II + Sbjct: 497 GVITDQKFTQPPPRYNEGSLVRELEK-----------------RGIGRPSTYAEIISKVQ 539 Query: 537 KRGFLTK-KGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRYQDFM 592 +R ++ K G T GK + L P+ TA E L + + + + Sbjct: 540 QRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLL 599 Query: 593 QPLVGTLYQLIDQAKR----TPVRQFRGIVAPGSGGSADKK 629 + + +D++K+ P + IV G KK Sbjct: 600 KSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKK 640 >UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID=Q28MI5_JANSC Length = 907 Score = 438 bits (1126), Expect = e-121, Method: Composition-based stats. Identities = 143/655 (21%), Positives = 244/655 (37%), Gaps = 107/655 (16%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + + E P+ A+ I L G+ V GH+ + D Sbjct: 1 MPVVVVESPAKAKTINKYL-------------GSDYTVLASYGHVRDLPSKDGSVD---- 43 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL- 119 P + + K + I L + + ++ A DPDREG+ + + + L Sbjct: 44 ------PEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQEALT 97 Query: 120 -QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + A + V R N + AV +A+ R + L + LAR D+L G N++ Sbjct: 98 SRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVD--MELVEAYLARRALDYLVGFNLS- 154 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +L R G S GRVQ+ L LVV R+ EIE F ++++ V+A + TP + A Sbjct: 155 --PVLWRKL--PGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + L A V +S + V+ K + + PF S LQ Sbjct: 211 RLTVLGGKKL---DRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA+++ G+ A+ + Q+LYE ITY R+D + E + + D Sbjct: 268 QEASRKLGMGAKQAMSTAQRLYEAGH-ITYMRTDGIDMAPEAVEDARGAIKT--RYGVDY 324 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTE-NEAKVYNLIARQYLMQF 414 +P +N+ + +AH + PT S A N L+E ++ K+Y+LI ++ + Sbjct: 325 VPGK--PRIYKNKAKN--AQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQ 380 Query: 415 CPDAVFRKCVIE--LDIAKGKFVAKARFLAEAGWRTLLGSKERD--EENDGTPLPVVAKG 470 A + + D + + A + + G+ + D ++ D LP V+ G Sbjct: 381 MEAARLERTTVTIASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAG 440 Query: 471 DELLCE-------------------------------------KGEVVERQTQPPRHFTD 493 D L + T PP +T+ Sbjct: 441 DPLKPSADAMADDYAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTE 500 Query: 494 ATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDA 553 ATL+ M + +G +T A I++ + RG++ K + D Sbjct: 501 ATLVKRMEELG-----------------IGRPSTYASIMDTIQNRGYVIKDKGRLIPEDK 543 Query: 554 GKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ 605 G+ + L R D TA E L ++S Y+D + ID+ Sbjct: 544 GRLVTVFLSNYFNRYVQYDFTADLEQQLDEVSAGDRHYKDVLDRFWRDFRAAIDE 598 >UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepID=B3DUA2_BIFLD Length = 1028 Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats. Identities = 138/659 (20%), Positives = 232/659 (35%), Gaps = 112/659 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A I D L K G V +GH+ + AQP + Sbjct: 4 KLVIVESPTKAHKIGDYLGK-------------GYTVMASVGHIRDLAQPSQVPAADKAK 50 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ + ++ +K L A E+ A D DREG+ + ++ L Sbjct: 51 FGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIAWHLVQTL 110 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + V+R + +++ A+ +++ R + + R D LYG ++ Sbjct: 111 K----PEVPVKRMVFHEITKNAINASLNNTRDVDG--NMVDAQETRRILDRLYGYELS-- 162 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA------- 232 +L R G LS GRVQ+ L+V R+ E F ++++ A + P Sbjct: 163 -PVLWRKVG--PGLSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAE 219 Query: 233 -DERFTAIWQPSEACEPYQDEEGRL-----------LHRPLAEHVVNRISGQPAIVTSYN 280 R A+ A +G+L L A V + V S Sbjct: 220 FSARMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVAEALRTADFTVMSME 279 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S LQ A R G+ A+ V+ Q LYE + ITY R+D L +E Sbjct: 280 TKPYRRRPQPPFTTSTLQQTAGNRLGMGARVVMRAAQSLYE-NGYITYMRTDSVTLSQEA 338 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR------SSAIN 394 NA+S H D + + + +AH I P A Sbjct: 339 ITAAR---NAVSYHFGD---KFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASK 392 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK------FVAKARFLAEAGWRT 448 L ++ ++Y LI ++ L DA + L G F A + G+ Sbjct: 393 LPGDQLRLYTLIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMK 452 Query: 449 LLGSKER----------------------------DEENDGTPLPVVAKGDELLCEKGEV 480 G + D T LP ++ G ++ E Sbjct: 453 ATGEGRKPKAAAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEP 512 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 +TQPP +T+ATL+ + +G +T A II + RG+ Sbjct: 513 DGHETQPPARYTEATLVKTLE-----------------AKEIGRPSTYASIISTIMDRGY 555 Query: 541 LTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + ++GR + + ++ L TA E+ L +I+ + +D++ Sbjct: 556 VYERGRALIPSWLAFSVTKLLETNFPKLVDYQFTAEMENGLDRIAHGEESGRDWLTHFY 614 >UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angulatum DSM 20098 RepID=C4FH65_9BIFI Length = 996 Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats. Identities = 131/639 (20%), Positives = 235/639 (36%), Gaps = 92/639 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ AR I+ L G+G V +GH+ + AQP + Sbjct: 6 KLVIVESPTKARKISGYL-------------GDGYTVMASVGHIRDLAQPSQVPAADKEH 52 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ K + +K L +A E+ A D DREG+ + +++ L Sbjct: 53 YGKFGVDVNDGFKPYYIVGADKRKTVADLKSALKKADELYLATDEDREGEAIAWHLVETL 112 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + +++ A+++++++ R + + R D LYG ++ Sbjct: 113 K----PKVPVKRMVFHEITKNAIKQSLEQTRDVD--ADMVDAQETRRILDRLYGYELS-- 164 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE----- 234 +L R G LS GRVQ+ L+V R+ E F ++++ A + + Sbjct: 165 -PVLWRKVG--PGLSAGRVQSVATRLIVERERERMAFTRASYWDIVAKLAAANTQGERVG 221 Query: 235 ---RFTAIWQPSEACEPYQDEEGRL-----------LHRPLAEHVVNRISGQPAIVTSYN 280 R ++ +G+L L + A V + P V S Sbjct: 222 FDARMVSLGGRRLVGSKDFGADGKLTPAGFADNVCQLSQTDAAAVAQELEHAPFTVMSME 281 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S LQ A R G+S++ + Q LYE + ITY R+D L E Sbjct: 282 SKPYRRRPLPPFTTSTLQQTAGNRLGMSSRATMRAAQGLYE-NGYITYMRTDSVTLSSEA 340 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR------SSAIN 394 A + L D + +AH I P A Sbjct: 341 IAAARNAVEY--HFGKSFLSDAPKQYDTKT----AGAQEAHECIRPAGARFHDPDELATR 394 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI-----AKGKFVAKARFLAEAGWRTL 449 + ++ K+Y LI ++ L DA +++ + F A + G+ Sbjct: 395 VPSDQLKLYTLIWQRTLASQMADATGSTATVKISAPAGGHGEALFQASGTVIDFPGFMKA 454 Query: 450 LGSK---------ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM 500 G + + + LP ++ G L + +TQPP +T+A+L+ + Sbjct: 455 TGEQHHAAKQGGRKGENAEGNASLPPMSAGQRLDVADVQADGHETQPPARYTEASLVKTL 514 Query: 501 TGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS 560 +G +T A II + RG++ ++GR + + A+ Sbjct: 515 E-----------------AKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFAVVKL 557 Query: 561 LP---EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 L TA E+ L QI+ + +D++ Sbjct: 558 LETKFPKLVDYQFTADMENGLDQIAHGKQTGRDWLTRFY 596 >UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 RepID=D0D7V2_9RHOB Length = 918 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 133/697 (19%), Positives = 256/697 (36%), Gaps = 109/697 (15%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + + E P+ A+ I L G+ V GH+ + D Sbjct: 1 MPVVVVESPAKAKTINKYL-------------GSDYTVLASYGHVRDLPAKDGSVDTDHD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + K + I L + ++ A DPDREG+ + + + L Sbjct: 48 FEMTW----------EIANDSRKHVAAIAEALKNDNSLILATDPDREGEAISWHLREALT 97 Query: 121 LAPEKRQQ--VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V R N + AV A+ R PL + LAR D+L G N++ Sbjct: 98 KRRSIKKDTAVSRVTFNAITKSAVTEAMQNPREID--APLVEAYLARRALDYLVGFNLS- 154 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +L R G S GRVQ+ L L+V R+ EIE F ++++++KA + TP + + A Sbjct: 155 --PVLWRKL--PGARSAGRVQSVCLRLIVEREMEIEAFRPREYWQIKALLSTPRGQEYEA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + + + AE V ++ + + S + + + PF S LQ Sbjct: 211 RLTVLGGKKL---DRFDIGNATQAELAVQAVASRKLKIDSVEARPSTRNPSAPFMTSTLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA+++FG+ A+ ++ Q+LYE ITY R+D + E + + + Sbjct: 268 QEASRKFGMGARACMNAAQRLYEAGH-ITYMRTDGIDMAPEAITACRDAI--ADRYGKEY 324 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIP---TARSSAINLTE-NEAKVYNLIARQYLMQF 414 +P +N+ + +AH I P T ++++ L E ++ K+Y+LI ++ L Sbjct: 325 VPGS--PRIYKNKAKN--AQEAHECIRPTDMTRDAASLKLREDDQRKLYDLIWKRTLACQ 380 Query: 415 CPDAVFRKCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVAKGD 471 A + +E+ + A + + G+ + D ++D LP + +G+ Sbjct: 381 MEAARLERTTVEILSEDRQVGLRATGQVVLFDGFLKVYEEGRDDVSDDDENRLPQIMEGE 440 Query: 472 ELLCEKGEV--------------------------------------VERQTQPPRHFTD 493 K + + TQPP +T+ Sbjct: 441 PAAFAKATLQAQYDKASDKAEDVVEDAPAGMQKSSAAVLSDNGAVLATQSHTQPPPRYTE 500 Query: 494 ATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDA 553 ATL+ M + +G +T A +I + R ++ K+ + D Sbjct: 501 ATLVKRMEELG-----------------IGRPSTYASVITTIQDREYVRKEQNRLFPEDK 543 Query: 554 GKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 G+ + L + + TA E+ L ++S + Y+ + I + Sbjct: 544 GRIVTIFLLNFFRKYVGYEFTAELENELDEVSAGEMDYKSLLAKFWRDFSAAIGETSELR 603 Query: 611 VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 + + ++ + + P + Sbjct: 604 ISEVLDVLDEALAPQLYPPREDGS--DPRICPKCGQG 638 >UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_SOLUE Length = 934 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 135/657 (20%), Positives = 247/657 (37%), Gaps = 91/657 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K VV +GH+ + + D + Sbjct: 5 LVIVESPAKAKTINKYLGKQ-------------YVVKASLGHIKDLPKRDLAVDVEHGFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + K + ++ +I A DPDREG+ + + + L+ Sbjct: 52 P----------RYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAICFHLQEELRSK 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R + N++ +AVE+A + + L + AR D L G ++ Sbjct: 102 KDGPA-FFRVMFNEITKKAVEKAFE--KPLQVNTNLVDAQQARRVLDRLVGYKISPLLWD 158 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQT L ++V R+ EI F K+++ V ++ + Sbjct: 159 KVRRG-----LSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRLIK 213 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + DE L ++ + +V ++SG IV S + + + PF S LQ +++ Sbjct: 214 AN------DETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSS 267 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ S + + + Q+LYE LITY R+D ++ + + Sbjct: 268 RKLRFSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDV-------RHY 320 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + P + P + DAH AI PT+ + + L E+E K+Y LI + Sbjct: 321 IGERYGAPFLPPAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNR 380 Query: 410 YLMQFCPDAVFRKCVIELDIA-----KGKFVAKARFLAEAGWRTLLGS----KERDEEND 460 ++ A+F + I++ + F A G+ + + D+E Sbjct: 381 FVASQMMPALFDQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEEL 440 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP+V +G+ L E + T+PP + +ATL+ + D Sbjct: 441 KHRLPLVTEGEVLRLEAIRPEQHFTEPPPRYNEATLVKRLE-----------------AD 483 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT---RPDMTAHWESV 577 G+G +T A I+ + +R ++ K+ T+ G + L E TA E Sbjct: 484 GVGRPSTYATILSTIQEREYVNKEAGRFTPTELGMVVTDLLLESFDDIFDVKYTARMEEE 543 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGSADKK 629 L +I E + ++ M G + + A+ + + ++ G K Sbjct: 544 LDEIEEGKLDWRAAMSEFYGRFDKDLKHAEEHMTDIKRMEKPTDLICEKCGRPLVIK 600 >UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6V581_NEORI Length = 827 Score = 437 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 134/668 (20%), Positives = 255/668 (38%), Gaps = 82/668 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ +AIA L K R V GH+ P+ S Sbjct: 1 MNVLIVESPTKGKAIAQYLGKDFR-------------VLSSFGHVRAL--PNKKGSVDVT 45 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + L + + + + + A+ + A DPDREG+ + +++ + Sbjct: 46 DSFEMLYKLTDTGETVVPQLIKD--------VKNATALYLATDPDREGEAISWHLVEVFK 97 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V R + +++ AV+ AI R E L + R D+L G +++ Sbjct: 98 ENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDE--NLVRAQRLRQALDYLVGFSIS--- 152 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L + G S GRVQ+ L ++ R+ EI F ++++ V ++ + Sbjct: 153 PVLWKKL--PGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDG-----EGLV 205 Query: 241 QPSEACEPYQDEEGRLLHR--PLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P++ ++ R+ R AE +V I P +V K + PF S +Q Sbjct: 206 IPTQLSHINGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQ 265 Query: 299 IEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 A+ G S + + + QKLYE LITY R+D +L E + Sbjct: 266 QTASTVLGFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQ-- 323 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLI 406 + LP+ V + + + +AH AI PT+ LT ++ K+Y LI Sbjct: 324 KKFGQEYLPESPV--LFKKKVKN--AQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLI 379 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFV--AKARFLAEAGWRTLLGSKERDEENDGTP- 463 + L DA+ I KF A A L G+ + +N G Sbjct: 380 WERALACQMSDAITSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVID 439 Query: 464 -LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 + +G ++ + T+PP +++A L+ + + + Sbjct: 440 FIKKHKEGAQVKVGDVLPTQNFTEPPHRYSEAGLVKHLEELG-----------------I 482 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLT 579 G +T A ++ +L +RG+ + + + G+ + L ++ TA E L Sbjct: 483 GRPSTYATVVSVLQERGYASIVNKSFIPENRGRLVSEFLVHFFSKYVEYHFTAEMEDRLD 542 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 ++++ + D +Q + + +++ ++ P+ + V +G A +K + + Sbjct: 543 KVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFV---NGALAKQKLVSAEVKVGD 599 Query: 640 KSPPADEV 647 K P ++ Sbjct: 600 KCPKCEKG 607 >UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_SYNAS Length = 769 Score = 436 bits (1122), Expect = e-120, Method: Composition-based stats. Identities = 134/692 (19%), Positives = 252/692 (36%), Gaps = 114/692 (16%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + + L V GH+ + + Sbjct: 5 LIIVESPTKVKTLKKYLGA-------------DYEVLASKGHIKDLPKK----------- 40 Query: 63 LADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 L I P+ + K + +K+ S I A DPDREG+ + + + + Sbjct: 41 --TLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEI 98 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + K +++ R L NDL + AI+ + R D L G ++ Sbjct: 99 KA---KNKEIYRVLFNDLTKNTILDAINHPGKLD--FNKYEAQQTRRILDRLVGYQIS-- 151 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 IL + LS GRVQ+ + ++ R+EEI+ F+ ++++ + + F A Sbjct: 152 -PILWEKV--KRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEAR 208 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-------------------PAIVTSYN 280 ++ ++ + A +V+R+SG +V+ Sbjct: 209 LI------KITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLE 262 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET--------HKLITYPRSD 332 K + + PF+ S LQ EA++ SA+ + QKLYE LITY R+D Sbjct: 263 KKEVKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTD 322 Query: 333 CRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA 392 + E+ + + + P + R K DAH AI P++ + Sbjct: 323 SVRIAEDALKEVRS-------YIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYN 375 Query: 393 IN-----LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWR 447 L+ ++ ++Y LI +++ A++ + +E+ F A+ L G+ Sbjct: 376 PQKIKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYT 435 Query: 448 TLLGSKERDEE-----NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + + D+E G LP + +G+ L K ++ TQPP F++A+L+ + Sbjct: 436 IVYTEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEE 495 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 +G +T A I+ + R + + H T+ G + L Sbjct: 496 QG-----------------IGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLV 538 Query: 563 EMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK---RTPVRQ--F 614 + TA E+ L I E + + + +Q + + +A+ + R+ Sbjct: 539 KNFPKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETP 598 Query: 615 RGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 ++ K K A + PA + Sbjct: 599 TDLICEKCQSPMVIKWGKNGKFIACSNYPACK 630 >UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41D8C Length = 741 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 168/678 (24%), Positives = 281/678 (41%), Gaps = 81/678 (11%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGD--------GFIECGNGQVVTWCIGHLLEQAQP 51 M + I+EKP A IA L +K F E G V +GHL Sbjct: 1 MHEVIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSA 60 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 + D DL VP ++++ + +N IK+ A + VHA D D EG L+ Sbjct: 61 SSRDR-----LGFDLTWVP-AYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLI 114 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 L Y + R + L + + A + +R + +AR D+ Sbjct: 115 GYNALKYA-CGNNAEAKASRMKFSTLTKKDIVEAYNTMRDID--IRQVDHGIARHMLDYY 171 Query: 172 YGINMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 YG+N++ A R + + + LS GRVQTP L ++V R++EI++FV + ++ +KA Sbjct: 172 YGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKA---- 227 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 S+ EG++ A+ + G A VTS P+ Sbjct: 228 -----------KSDYDIIADHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPI 276 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 PF+L LQ EA FG S + Q LY +YPR+ + LPE N Sbjct: 277 PFNLGGLQSEAHTVFGFSPKRTQVAAQNLY-VGGYTSYPRTSSQKLPESL-----DFKNI 330 Query: 351 ISVHAPD-LLPQPVVDPDIRNRCWDDKKVD-AHHAIIPTARSSAINLTENEAKVYNLIAR 408 + A D + + D + + + KK D AH AI PT + NL+ +EAK+Y+LI Sbjct: 331 FAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPS-NLSADEAKIYSLIVY 389 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 +++ F ++ + L +A KF + ++ GW K+++ + P + Sbjct: 390 RFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQEND----AFPPIN 445 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGD+L K V E++T+PP + +A+L+ + LGT+ATR Sbjct: 446 KGDQLKIHKILVEEKETKPPARYNEASLIKELEK-----------------RELGTKATR 488 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQ 585 A I+ L+ R ++ +G+ I G + +L E T ++T +E L I + Sbjct: 489 ADIVAKLYDRKYI--EGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDK 546 Query: 586 CRYQDFMQPLVGTLYQL---IDQAKRTPVRQFRG------IVAPGSGGSADKKKAAPRKR 636 + ++ + + I+Q K+ + G +V S G K+ +PR + Sbjct: 547 YTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTK 606 Query: 637 S---AKKSPPADEVGSGA 651 + + P +V Sbjct: 607 NTFVGCSNFPKCKVTYSL 624 >UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CC0A9 Length = 1049 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 138/690 (20%), Positives = 264/690 (38%), Gaps = 103/690 (14%) Query: 1 MR--LFIAEKPSLARAIADVLPKPHRKGDGFIECGN--------------GQVVTWCIGH 44 M+ L +AEKPS+A+ I+ VL +K N + T GH Sbjct: 1 MKQILNVAEKPSVAKEISRVLGNGSQKTLDSESKYNPVFQFEYKLKQEQVNMLFTSVTGH 60 Query: 45 LLEQAQPDAYDSRYARWNLADLPIVPEK----WQLQPRPSVTKQLNVIKRFLHEASEIVH 100 L+ Q +D ++ W + ++ ++ + ++ Q N+IK + + ++ Sbjct: 61 LISQ----KFDDKFKNWKSFNPSVLLDQSSEILKFVESDKISIQRNLIK-WARQVDTLIL 115 Query: 101 AGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCV 160 D DREG+ + E R + L+ V AI+ LR + L Sbjct: 116 WLDCDREGEAIAYE----------------RAWFSSLDRLNVTNAINNLRDPRK--ELSE 157 Query: 161 SALARARADWLYGINMTRAYTILGRN-----AGYQGVLSVGRVQTPVLGLVVRRDEEIEN 215 + +R D G T T+ +N + V+S G Q P LG VV R +I Sbjct: 158 AVESRMEIDLRIGSAFTVFQTLNLKNNFQSLKDKKEVISYGPCQFPTLGFVVDRYNQILK 217 Query: 216 FVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--- 272 F + F+ ++ + + + GRL + +A + Sbjct: 218 FQDEKFWYIQPSYQWKDNNK--------TLTVDLKWSRGRLFDQAIASVFYLNCTQNEDG 269 Query: 273 ----PAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITY 328 IV N++ ++ P P + L + + ++++ ++ ++LY++ I+Y Sbjct: 270 EYDPKGIVVKKNERDTTKIRPYPLTTVDLTKQGCRILRMASEKIMHTAEQLYQS-GYISY 328 Query: 329 PRSDCRYLPEEHFAG--RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVD-AHHAII 385 PR++ P+ G V N ++D R K+ D AH I Sbjct: 329 PRTETNKYPDTFQNGQLMDLVRNQKQSDEWGFYSSNLIDQGNFQRPRAGKQDDKAHPPIH 388 Query: 386 PTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAG 445 P ++ L E KVY I R +L DAV K +E+ F + E Sbjct: 389 PIKLANKNQLKPEEWKVYEFITRHFLASCGKDAVGAKTEVEVKFNDESFNIDGLVVKEKN 448 Query: 446 WRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 + + E+ + + +P + G ++ +K + E +T PP+ T++ L+ M Sbjct: 449 YLEIWTY----EKWNDSIVPPLQPGQVIIPQKILLQEGKTTPPKPLTESELIDMMNK--- 501 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM 564 +G+GT+AT I + KRG+ K T G AL H+ ++ Sbjct: 502 --------------NGIGTDATMHDHILTIQKRGYAVKNQHLMFTPTPLGLALCHAYDQL 547 Query: 565 ---ATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT---LYQLIDQAKRTPVRQFRGIV 618 ++PD+ A E +++ ++E + + + ++ +Y+ ++Q K+ ++ Sbjct: 548 GLTLSKPDLRAKMERLMSDVAEGKTTREAIITQIMEEMKSIYKTVEQNKQLFIKSV---- 603 Query: 619 APGSGGSADKKKAAPRKRSAKKSPPADEVG 648 G +++ + + P E G Sbjct: 604 ----GEQLKEQENSASTLNNSNIQPGSECG 629 >UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=Schistosoma mansoni RepID=C1LZJ7_SCHMA Length = 1165 Score = 435 bits (1118), Expect = e-120, Method: Composition-based stats. Identities = 127/629 (20%), Positives = 249/629 (39%), Gaps = 72/629 (11%) Query: 1 MR-LFIAEKPSLARAIADVLP-KPHRKGDGFIECGNGQ-------------VVTWCIGHL 45 M+ L +AEK A+ I+++L + + +G + V+T GHL Sbjct: 26 MKILNVAEKNDAAKNISEILSRGGYHRREGISKFNKIYEFPMNLNGQNVMMVMTSVSGHL 85 Query: 46 LEQAQPDAYDSRYARWNLADLPIVPE-KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDP 104 + Y W+ + ++ + Q ++R + +++ D Sbjct: 86 TNY----DFLPNYKSWHSCNPMVLFDAPIVKQVLKDYEPIKQTLQREVRSCQKLIIWTDC 141 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREG+ + EV+D + + ++ R +++ P AV RA+DRL + Sbjct: 142 DREGENIGVEVIDVCREI-KPNIEILRARFSEITPAAVHRAVDRLTIPD--YNASTAVDV 198 Query: 165 RARADWLYGINMTRAYTILGRNAGYQGV----LSVGRVQTPVLGLVVRRDEEIENFVAKD 220 R D G TR T+ R Q + +S G Q P LG VV R E++ FV++ Sbjct: 199 RQELDLRIGAAFTRFQTLRLRRVFPQALSDQLISYGSCQFPTLGFVVERFREVDQFVSEP 258 Query: 221 FFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSY 279 F+ + + E +Q + GRL + + + + Sbjct: 259 FWRIVVTVSRD------------EKTTEFQWQRGRLFDQDCCRAYYEHLNQNRYGQIVEV 306 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 + +++ P L+ A+++ + A+ + + ++LY I+YPR++ + P + Sbjct: 307 IKRPKTKWRPTALDTVELEKLASRKLQMGAKYAMQLAERLYN-KGFISYPRTETKIFPPD 365 Query: 340 HFAGRHAVMNAISVHAPDLLPQPV-VDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTEN 398 + D + + P+ +N DK AH I P + L + Sbjct: 366 LDLKSLVHVQINDSRWSDFATRILERGPNPKNGKSSDK---AHPPIHPLKVGDS--LQGD 420 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 EA++Y L+ R +L DA + ++ L I F +K + + + E+ Sbjct: 421 EARLYELVTRHFLACLSTDAEGAETIVRLCIDGELFESKGLMILALNYLEVYIYDRWAEK 480 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + +PV G+ +L + +V+ QT PP T+A L+S M Sbjct: 481 D----MPVFQLGEWILPDNIQVLTGQTCPPPLLTEADLISLM-----------------D 519 Query: 519 TDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHW 574 G+GT+AT A IE + +R ++ ++ +++ G L M ++P++ + + Sbjct: 520 RHGIGTDATHAEHIETIKQRLYVGLEQNKFLVPGQLGMGLVEGYDSMGFEMSKPNLRSEF 579 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLI 603 E+ L I E + ++ + + +L Sbjct: 580 EADLKLICEGRKTKEEVLHHHLNKYKELF 608 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteri... 722 0.0 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 640 0.0 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 636 0.0 UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 629 e-178 UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteri... 627 e-178 UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 625 e-177 UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A... 622 e-176 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 621 e-176 UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria R... 618 e-175 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 616 e-175 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 610 e-173 UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS1... 607 e-172 UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei A... 604 e-171 UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=... 603 e-171 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 602 e-170 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 601 e-170 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 600 e-170 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 600 e-170 UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_... 597 e-169 UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii... 595 e-168 UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salex... 594 e-168 UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepI... 593 e-168 UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ... 593 e-168 UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum D... 592 e-167 UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_... 590 e-167 UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacte... 588 e-166 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 586 e-166 UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_... 586 e-166 UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organism... 584 e-165 UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BL... 583 e-165 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 582 e-164 UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE 581 e-164 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 580 e-164 UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105... 578 e-163 UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 ... 577 e-163 UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales Rep... 576 e-162 UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BG... 575 e-162 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 574 e-162 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 573 e-162 UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q2... 573 e-162 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 572 e-161 UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A... 571 e-161 UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bactero... 571 e-161 UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT 571 e-161 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 570 e-161 UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q0... 565 e-159 UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_... 564 e-159 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 563 e-159 UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 561 e-158 UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria Rep... 561 e-158 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 560 e-158 UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca D... 558 e-157 UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase... 558 e-157 UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria Re... 558 e-157 UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum... 557 e-157 UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychroph... 557 e-157 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 557 e-157 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 556 e-157 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 556 e-157 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 555 e-156 UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=... 555 e-156 UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6... 554 e-156 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 553 e-156 UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP... 552 e-155 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 552 e-155 UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0... 552 e-155 UniRef50_C6BT42 DNA topoisomerase type IA central domain protein... 551 e-155 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 549 e-155 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 549 e-155 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 549 e-154 UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62... 548 e-154 UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q... 547 e-154 UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW... 547 e-154 UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1... 546 e-154 UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamie... 546 e-154 UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_... 546 e-153 UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q... 545 e-153 UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 ... 545 e-153 UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 544 e-153 UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0... 544 e-153 UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID... 544 e-153 UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D... 544 e-153 UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID... 543 e-153 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 541 e-152 UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9... 541 e-152 UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermed... 541 e-152 UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actino... 540 e-152 UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extor... 539 e-151 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 538 e-151 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 538 e-151 UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacter... 538 e-151 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 537 e-151 UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostri... 537 e-151 UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=... 536 e-151 UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q4... 536 e-151 UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8... 536 e-150 UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ... 536 e-150 UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autot... 535 e-150 UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C... 535 e-150 UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein... 535 e-150 UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP... 534 e-150 UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID... 533 e-150 UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID... 533 e-150 UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_... 533 e-149 UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans AT... 533 e-149 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 532 e-149 UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM... 530 e-149 UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepI... 530 e-149 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 529 e-148 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 529 e-148 UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_... 528 e-148 UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3... 527 e-148 UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C... 527 e-148 UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium haf... 526 e-148 UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2M... 526 e-147 UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms R... 526 e-147 UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP... 525 e-147 UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeen... 525 e-147 UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria... 525 e-147 UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales Re... 525 e-147 UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=... 524 e-147 UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=... 524 e-147 UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus ... 524 e-147 UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP... 524 e-147 UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria R... 524 e-147 UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae Rep... 523 e-146 UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group... 522 e-146 UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiac... 522 e-146 UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum ... 521 e-146 UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum ... 521 e-146 UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C... 521 e-146 UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnson... 521 e-146 UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID... 520 e-146 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 519 e-146 UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotubercu... 519 e-145 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 515 e-144 UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damsela... 515 e-144 UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID... 514 e-144 UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B... 514 e-144 UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphi... 513 e-144 UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiacea... 513 e-144 UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_... 513 e-144 UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris... 513 e-143 UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E... 513 e-143 UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsula... 512 e-143 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 512 e-143 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 511 e-143 UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio ye... 511 e-143 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 511 e-143 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 511 e-143 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 510 e-143 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 509 e-142 UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi... 509 e-142 UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Gro... 509 e-142 UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 508 e-142 UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID... 507 e-142 UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 507 e-142 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 506 e-142 UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite gro... 506 e-141 UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QY... 506 e-141 UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter prot... 506 e-141 UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocell... 506 e-141 UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0... 506 e-141 UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_... 504 e-141 UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria Re... 504 e-141 UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID... 502 e-140 UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacter... 502 e-140 UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GF... 502 e-140 UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms... 501 e-140 UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepI... 501 e-140 UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_... 501 e-140 UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_... 500 e-140 UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum... 500 e-140 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 499 e-140 UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepI... 499 e-139 UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa Rep... 499 e-139 UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola ... 499 e-139 UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID... 499 e-139 UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesti... 499 e-139 UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms ... 499 e-139 UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscole... 499 e-139 UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=... 496 e-138 UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID... 496 e-138 UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM ... 496 e-138 UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms Re... 496 e-138 UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlan... 495 e-138 UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q18... 494 e-138 UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1... 494 e-138 UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 R... 494 e-138 UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=... 493 e-138 UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota Rep... 493 e-137 UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis... 492 e-137 UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7... 491 e-137 UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shew... 491 e-137 UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus ... 491 e-137 UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota Re... 491 e-137 UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax... 489 e-136 UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A... 489 e-136 UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID... 488 e-136 UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4... 488 e-136 UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7... 488 e-136 UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC ... 487 e-136 UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1V... 486 e-136 UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D2... 486 e-135 UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LV... 486 e-135 UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_... 486 e-135 UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_... 484 e-135 UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms ... 484 e-135 UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tas... 483 e-135 UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum... 483 e-135 UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=... 483 e-134 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 483 e-134 UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LR... 482 e-134 UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas... 481 e-134 UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 T... 481 e-134 UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei Re... 480 e-134 UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 480 e-134 UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1... 479 e-133 UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU... 479 e-133 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 479 e-133 UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepI... 479 e-133 UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA)... 478 e-133 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 477 e-133 UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL... 477 e-133 UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp.... 477 e-133 UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepI... 476 e-133 UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1... 476 e-132 UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_... 476 e-132 UniRef50_B6A9W0 DNA topoisomerase n=2 Tax=Eimeriorina RepID=B6A9... 476 e-132 UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus gr... 475 e-132 UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis A... 475 e-132 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 474 e-132 UniRef50_C8WG68 DNA topoisomerase type IA central domain protein... 474 e-132 UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyti... 473 e-132 UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular or... 473 e-131 UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepI... 473 e-131 UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepI... 470 e-131 UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=... 470 e-130 UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales Rep... 469 e-130 UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytog... 468 e-130 UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angula... 468 e-130 UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_... 468 e-130 UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteob... 468 e-130 UniRef50_Q55KM2 DNA topoisomerase n=3 Tax=Agaricomycotina RepID=... 468 e-130 UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeu... 467 e-130 UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales Rep... 467 e-130 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 467 e-130 UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genom... 467 e-130 UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6... 467 e-130 UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Enta... 466 e-129 Sequences not found previously or not previously below threshold: >UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteria RepID=TOP3_ECOLI Length = 653 Score = 722 bits (1865), Expect = 0.0, Method: Composition-based stats. Identities = 653/653 (100%), Positives = 653/653 (100%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR Sbjct: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ Sbjct: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY Sbjct: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW Sbjct: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE Sbjct: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP Sbjct: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF Sbjct: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV Sbjct: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF Sbjct: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 Query: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY Sbjct: 541 LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY 600 Query: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA Sbjct: 601 QLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 640 bits (1650), Expect = 0.0, Method: Composition-based stats. Identities = 255/690 (36%), Positives = 357/690 (51%), Gaps = 50/690 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L++ EKPS R I VL R +G++ G G VTWCIGHL+E PD Y + Sbjct: 1 MILYLCEKPSQGRDIGRVLGATSR-HEGYV-AGAGVCVTWCIGHLMEMVAPDGYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPI+P++WQL+ KQ VI+ L +E+V A D DREG+ + EVL+ Q Sbjct: 59 WRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQ 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++ R ++ L+ ++ +A+ L + PL + L R+RADW+ G+N+TRAY Sbjct: 119 ----YRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAY 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR GY GVLSVGRVQTP L LVV RD IENF D+FE+ A + F A W Sbjct: 175 TLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFA-LHRVHSGTFIAKW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P D EG L R LAE V++++ G +T KR E PLP LS LQ E Sbjct: 234 VPPPKP---CDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLPLELSTLQQE 290 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A++R+G+ A+ L+I Q LYE HK +TYPR+DCRYLP F AV+ ++ + L P Sbjct: 291 ASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTP 350 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDA 418 D +R++ W+DKK+ AHHAIIPTA I+ L+ EA +Y+LI R YL QF P Sbjct: 351 LVEGADAQLRSKAWNDKKITAHHAIIPTAAKINIDALSREEALLYDLIRRHYLAQFYPPF 410 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLL--GSKERDEENDGTPLPVVAKGDELLCE 476 + + VI+ +A F A R GW+ +L ++++ + D LPVV G+ E Sbjct: 411 EYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIE 470 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 E+ ++QT+PP +T+ TL+ AM + + V+D L+KILR T G+GTEATRA I+E L Sbjct: 471 GAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILETLI 530 Query: 537 KRGFLTKKGRY-IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 KR L K+G+ + S AG+ L +LP T P TA WE L I+ + F+ Sbjct: 531 KRNLLAKQGKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLAKS 590 Query: 596 VGTLYQLIDQAKRTPV-----------------------------------RQFRGIVAP 620 L +LI + + P Sbjct: 591 ELWLNKLIHNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRSKAEVTPTPNAAPLCP 650 Query: 621 GSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 GG ++K+ + Sbjct: 651 QCGGPMLQRKSPQGAFWSCAEQATCTGTRP 680 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 636 bits (1641), Expect = 0.0, Method: Composition-based stats. Identities = 252/653 (38%), Positives = 358/653 (54%), Gaps = 16/653 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQ-VVTWCIGHLLEQAQPDAYDSRYA 59 M+LF+ EKPS IA VL ++G+G + +GQ VTW IGHL+EQ P+ YD + Sbjct: 6 MKLFLCEKPSQGNDIAKVLGA-TKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFK 64 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 +W LPI+P KW L P+ KQ NV+ + + +A +V A D DREG+ + E+LD Sbjct: 65 KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA 124 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R Q++R ++ L+ ++ +A+ L++N E +PL + LAR+RADWL G+N +R Sbjct: 125 GF----RGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRL 180 Query: 180 YTILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+L + GYQG LSVGRVQTP L LVV RD EI+NF+ K F ++ + T Sbjct: 181 YTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQ 240 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSAL 297 P E Y D +G L + + +I A V S KRE ++APL F+LS L Sbjct: 241 YVIP----EQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDL 296 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA + +GL AQ VLDI Q LYETHK TYPR+DC YLPE FA ++ + Sbjct: 297 QSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNR 356 Query: 358 LLP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFC 415 L P +++ + ++R W+DKK+ AHH IIPT + +++ E K+Y+LI R+YL QF Sbjct: 357 LHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFL 416 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P + K I L + A+ L GW+ L G ++++ LP + +G Sbjct: 417 PVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQI 476 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E+ QT PP HFT+ TLL+AM ARFV D+ LK+ LR T+GLGTEATRAG I+ L Sbjct: 477 SDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGL 536 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +GFL KKG+ + +TD L +LP+M P +TA WE L QI+E+ + FMQ Sbjct: 537 IDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQ 596 Query: 596 VGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + L+ + + P G K+ + P + Sbjct: 597 EVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQ 649 >UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AY08_RUBXD Length = 701 Score = 629 bits (1623), Expect = e-178, Method: Composition-based stats. Identities = 225/660 (34%), Positives = 344/660 (52%), Gaps = 38/660 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL +AEKPS+ R IA L + R+GD + G+G VVTW +GHL E A PDAY + Y R Sbjct: 1 MRLIVAEKPSVGRDIAGALGRHRREGDALV--GSGWVVTWALGHLAELAPPDAYGAEYKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDY 118 W+L +LPI+PE+++++ P ++ ++R++ + +E+V+A D REG+L+ + Sbjct: 59 WSLQNLPILPERFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACDAGREGELIFAYLYQL 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + V+R ++ L P+A+ LR PL +A +RA ADW+ G+N TR Sbjct: 119 SRC----EKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRAEADWIVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AY++ G VLSVGRVQTP L L+V R+ EIE+F + FF V A + Sbjct: 175 AYSVRFSRPG--DVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARFARDGK-TYDG 231 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +W ++++E RL R AE + ++ G +V +R SE PL + L+ LQ Sbjct: 232 LW--------FREKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDLTELQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA------IS 352 A R+G +A+ L Q LYE KLITYPR+ RYL + + A ++ Sbjct: 284 RNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGLPELA 343 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 A LL + + R DD KV HHAI+PT R + L +EAKVY+L+AR++L Sbjct: 344 PFAGRLLAAGSL--PVGRRVVDDSKVTDHHAIVPTDRKPSGGLPPDEAKVYDLVARRFLA 401 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVAKGD 471 F P A F + + F++K R + EAGWR L +E + LP V G Sbjct: 402 VFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALPPVEAGQ 461 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 E K V E +T+PP ++++ LL AM + V+D++L++ ++ + GLGT ATRA I Sbjct: 462 EWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDS-GLGTPATRAAI 520 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQD 590 IE L K G++ ++ + + T G+AL L + P+MTA WE L +I + R D Sbjct: 521 IERLIKVGYVEREKKALVPTAKGRALISLLADSPLSSPEMTARWERRLARIERGEERRPD 580 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRG--------IVAPGSGGSADKKKAAPRKRSAKKSP 642 FM + G +++ +R + P G + K A + +K+ Sbjct: 581 FMSDISGFAASVVEGVRRMEGEKIAAPGGGGEALGACPKCGSPVVETKKAYGCSAWRKTG 640 >UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteria RepID=TOP3_VIBCH Length = 647 Score = 627 bits (1617), Expect = e-178, Method: Composition-based stats. Identities = 375/644 (58%), Positives = 473/644 (73%), Gaps = 7/644 (1%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RLFIAEKPSLARAIAD LPKPH+K G I C NG +VTWCIGHLLEQ +PDAYD RY +W Sbjct: 3 RLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 N+ADLPI+PE+WQL+PR S ++QL V+++ L EA++I+HAGDPDREGQLLVDEV+DY ++ Sbjct: 63 NMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKV 122 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K++ VQR LI+DLN AV+RA+ LRSN EF+PL VSALAR+RADWLYG+NM+RAYT Sbjct: 123 PKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYT 182 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF---TA 238 +LG+ AGYQGVLSVGRVQTPVLGLVVRRDEEIE+F+ D+F + A I + A Sbjct: 183 LLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRA 242 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+PSEAC P+QDEEGR+ +R L ++V +RI+ QPA VT + ++APLP+SLSALQ Sbjct: 243 RWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQ 302 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 I+AAKR+ SAQ VLD+CQ LYE HKLITYPRSDCRYLP+EH A V+ AI+ +A ++ Sbjct: 303 IDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEM 362 Query: 359 LPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 + D +R++ W+D KVDAHHAIIPT + +++N L+ +E KVY LIARQYLMQF P Sbjct: 363 VTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYP 422 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 A++ + + +IA G F+AK R L AGW +L ++ ++E +P + G L C Sbjct: 423 AAIYAEAKLVFNIAGGIFIAKGRQLLSAGW-KVLTGQQDEQEECVDKVPPLPVGIVLQCR 481 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 +GE+ +RQT+PPRHFT+ATLL AMTGIARFV DK+LKKILR TDGLGTEATRAGI++ LF Sbjct: 482 EGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLF 541 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 KRG L + + I ST AG+ L H+LP AT PDMTAHWE L I+EK YQ FMQ L Sbjct: 542 KRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQ 601 Query: 597 GTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 G L QLI+Q + PV + P A K+ K A+ Sbjct: 602 GRLEQLIEQVQVAPVPVSLQAL-PAVSKPAFKRTRRAPKSKART 644 >UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=A1U3N5_MARAV Length = 722 Score = 625 bits (1612), Expect = e-177, Method: Composition-based stats. Identities = 318/665 (47%), Positives = 407/665 (61%), Gaps = 18/665 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG---QVVTWCIGHLLEQAQPDAYDSR 57 M L+IAEKPSLARAIA LP PH KG G+I CG G V+WCIGHLLE A+P Y+ Sbjct: 1 MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPA 60 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W + DLP+ PE WQL P+ SV Q V++ + +A I HAGDPDREGQLLVDEVL Sbjct: 61 WKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLR 120 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 YL + V+R LINDL P+AV RAI R N EF PL SALAR RADWLYGIN+T Sbjct: 121 YLG----TKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLT 176 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE--- 234 R YT+ + G QGV SVGRVQTPVLGLVV RD IE+F K ++ V+A E Sbjct: 177 RFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQ 236 Query: 235 -RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 F A W P + + + DEE RLL + +AE +V ISG+P + + E PLP S Sbjct: 237 RPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLS 296 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LSALQIEA + + + A++VLD Q LYE H+LITYPRSD RYLPEEHF+ R AV+ AI+ Sbjct: 297 LSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIAR 356 Query: 354 HAPDLLP-QPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYL 411 APDL + R+ W+D+KVDAHHAIIPT + L+ E K+Y+LI+R YL Sbjct: 357 VAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYL 416 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVAKG 470 MQF PDAV R+ + + I +F A + E GW+TL +E +E + PLP + K Sbjct: 417 MQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKN 476 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + +LC + ER+TQPP+HFTDATLLSAMT IARFV D +L+K LR TDGLGTEATRA Sbjct: 477 EPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAA 536 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 II+ LF+R +L ++ R+I +TD GK+L +LPE PD TA WE+ L + + + Sbjct: 537 IIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRA 596 Query: 591 FMQPLVGTLYQLIDQA----KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 F++ L + + QA I P +++ A PA + Sbjct: 597 FLESLKDEIRGFMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACK 656 Query: 647 VGSGA 651 Sbjct: 657 GTRPL 661 >UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A3EW25_9BACT Length = 684 Score = 622 bits (1605), Expect = e-176, Method: Composition-based stats. Identities = 278/659 (42%), Positives = 381/659 (57%), Gaps = 17/659 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA+VLP PH+KG GF+E G G +VTWC GH+LE A P+ YD ++A Sbjct: 1 MRLFIAEKPSLGRAIAEVLPGPHKKGAGFLETGGG-IVTWCFGHILEAAPPEEYDRKWAA 59 Query: 61 W--NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W + DLPIVP+ W+L P PS QL VI++ L EASEIVHAGDPDREGQLLVDEVL+Y Sbjct: 60 WPGSSGDLPIVPKTWKLSPVPSAKAQLAVIRKLLGEASEIVHAGDPDREGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L R+ V R ++ L+ +AV +A+ LRSN EF + +A R+RADWL G+N++R Sbjct: 120 LG----NRKPVLRIWLSSLDEKAVRQALSGLRSNREFAAMKEAAQVRSRADWLVGMNLSR 175 Query: 179 AYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AY+I R G VLS+GRVQTP L LVV RD EIE+FV+KDFF V+A + P F Sbjct: 176 AYSIAARKNGNPVAVLSIGRVQTPTLKLVVDRDREIESFVSKDFFTVEATLEAPGGA-FK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +W P+E P D GR + R +A V N Q + +SE PL ++LS L Sbjct: 235 TVWMPAEN-HPALDAAGRCIDRTVALGVANGTKAQKG-ILDIGKTEKSEPPPLVYALSTL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 ++A+K++ +SA+ VLD Q LYE KL TYPR+DC YLP+ + +++A+ Sbjct: 293 TMDASKKYAMSAKEVLDTAQSLYE-KKLTTYPRTDCEYLPQTQWGEAREILSALGRLPGL 351 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCP 416 D R+R W+ +KV AHH IIPT + A L+E E ++++L+ R+YL QF P Sbjct: 352 SSAASQADSARRSRAWNTEKVTAHHGIIPTREAGRAGGLSEKEVRIFDLVCRRYLAQFYP 411 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS--KERDEENDGTPLPVVAKGDELL 474 + + ++ + F AK + GW+++ G D + PLP ++ GD ++ Sbjct: 412 PFRYTETIVRTRLGGEPFQAKGTTPLDTGWKSVYGPEPDREDRKEPEPPLPALSSGDPVV 471 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 VV R+T PP +TD TL++AM + R + + + KKIL TDGLGTEATRA I+E Sbjct: 472 ARDCSVVARKTTPPSPYTDGTLVAAMKNVHRAMSNPEDKKILNETDGLGTEATRASILET 531 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ-CRYQDFMQ 593 LF RG+L K R I ST G+AL ++ + P TA WE L I+ Q +F+ Sbjct: 532 LFSRGYLEKSKRAIRSTPRGRALIDAVEPIVASPVTTAVWERSLESIATGQGENSGEFLS 591 Query: 594 PLVGTLYQLIDQAKRTPVRQ-FRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 +V T+ +L A V G + GG + + PA Sbjct: 592 KIVDTVSRLTKTALALRVVIPVEGKICSECGGVLRRLEGKFGPFLGCSGYPACRHLEKL 650 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 621 bits (1602), Expect = e-176, Method: Composition-based stats. Identities = 243/667 (36%), Positives = 358/667 (53%), Gaps = 26/667 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA- 59 M+LF+ EKPS A+ IA V+ R+ + GNG V W GHLLEQA+P+AY +++A Sbjct: 1 MKLFLCEKPSQAKDIARVIGAHQRRDN--FFQGNGVQVAWARGHLLEQAEPEAYGAQFAA 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 W + LP++PE+W++ + IK+ L +A+E+V A D DREG+++ E+L+ Sbjct: 59 PWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLEAC 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R++VQR ++ L+ ++ +A++ L + L + L RARADWL G+NMTR Sbjct: 119 H----YRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRL 174 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ R G+ G+LSVGRVQTP L L+VRR+ EI +FV+K F+ V A + F A Sbjct: 175 FTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGI-IFQAH 233 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+P+ Y D+E R +H A+ V A V + N+ + PLPF L LQ Sbjct: 234 WRPA---SQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQ 290 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A++R+G SA VL+I Q LYE HK TYPR+DC YLP A V++A+S P L Sbjct: 291 QAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPAL 350 Query: 359 LP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCP 416 + P +R W+D K+ AHHAIIPT ++ +N + E E VY LI YL QF P Sbjct: 351 QNVLAQLQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQFLP 410 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE----------ENDGTPLPV 466 D + + LDI +FVAK + GW L E D E LP Sbjct: 411 DQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEAGTETLPS 470 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G+ + ++ +VV+ T PP+ +TD TL++AM + F+ D LKK+L+ GLGTEA Sbjct: 471 LHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLGTEA 530 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 TRAGII L R + ++ + + +TD G L +LP T P MTA WE L Q+++ Sbjct: 531 TRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQGNL 590 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTP--VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 FMQ + L LI + P + P G ++++ + + + P Sbjct: 591 SLDVFMQKQISWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPD 650 Query: 645 DEVGSGA 651 + Sbjct: 651 CKGSVPL 657 >UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria RepID=Q3BT95_XANC5 Length = 670 Score = 618 bits (1595), Expect = e-175, Method: Composition-based stats. Identities = 249/657 (37%), Positives = 357/657 (54%), Gaps = 19/657 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS + I +L ++G+G + G+G VTWCIGHL+E A P+AYD + R Sbjct: 1 MRLFLCEKPSQGKDIGRILGA-TQRGEGCL-NGSGVTVTWCIGHLVEAAAPEAYDEQLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W++ LPI+P++WQ++ +P Q V+K L +A+++V A D DREG+L+ E++D Sbjct: 59 WSIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R ++R ++ LN ++ A+ +LR ++E +P+ SALAR+RADWL G+N++R + Sbjct: 119 ----YRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AGY GVLSVGRVQTP L LVV RD EI FV+ ++ + ++ T + FTA W Sbjct: 175 TVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSG-QAFTAQW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQI 299 + C D+ GR L +P+A+ +I A V S +R E PLPF L LQ Sbjct: 234 ISPDTC---TDDSGRCLQQPVAQQAAQQIRATGSAQVVSVETERVREGPPLPFDLGTLQE 290 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +K+ GL Q LDI Q LYETHK TYPRSD YLPE FA V++++ L Sbjct: 291 LCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLKTDFSLR 350 Query: 360 P-QPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 P +D R+R W+D KV AHH IIPT ++ ++E E VY LI YL QF P Sbjct: 351 PIIDQLDRTQRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPH 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND----GTPLPVVAKGDEL 473 F + V L + A + + GWR +L + +E++D LP + +G Sbjct: 411 HEFDRTVANLSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSC 470 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 ++ +TQP R +T L+ +M G+A+ V D LK+ L+ T G+GTEATRA II Sbjct: 471 QVADVDLKALKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIS 530 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L RG+L KKGR I ++DA L ++P P TA WE L I Q F+ Sbjct: 531 GLIARGYLMKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIG 590 Query: 594 PLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 + QLI Q ++ G P G ++ + P + Sbjct: 591 KQAAWISQLITQYASASLSIKVPHGPACPQCGAPTHQRSGKSGPFWSCSRYPDCKGT 647 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 616 bits (1588), Expect = e-175, Method: Composition-based stats. Identities = 203/661 (30%), Positives = 330/661 (49%), Gaps = 38/661 (5%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA +L KG G++E GN +VTW +GHL+ A+P+ YD +Y Sbjct: 1 MKSLVLAEKPSVAREIARIL-NCTIKGKGYLE-GNKYIVTWALGHLVTLAEPEDYDEKYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W DLP++P + + Q +++ + + E++ A D REG+L+ ++ Sbjct: 59 TWRTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + + +R I+ L +A+ RLR +E+ L SA+ RA ADWL G+N+T Sbjct: 119 QARCQ----KPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y LS GRVQTP L ++V R++EI+ FV DF+ VKA++ +F Sbjct: 175 RALTVK-----YNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANL-----GKFQ 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A W+ + R AE +VN++ + V + +SE PL + L+ L Sbjct: 225 AEWRDKSG------KHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTEL 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-SVHAP 356 Q +A K+FG +AQ L Q LYE HKL+TYPR+D RYL + + A+ + Sbjct: 279 QRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFA 338 Query: 357 DLLPQPVVDP-DIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQF 414 +L+ P I R D+ KV HHAIIPT ++ LT E +Y+LI R+++ F Sbjct: 339 ELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVF 398 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-----EENDGTPLPVVAK 469 P +++ + + IA F A + + GW+ + ++ R+ ++ LP + K Sbjct: 399 YPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKK 458 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 GD++ + V+ QT+PP +T+A+LLSAM +F++D+ LK+ ++ + GLGT ATRA Sbjct: 459 GDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKES-GLGTPATRA 517 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 IIE + ++ ++G+ + T G L +P + D+TA WE L I+ + + Sbjct: 518 EIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRT 577 Query: 590 DFMQPLVGTLYQLIDQAKRTPV----RQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 F+ + +++ + G P K Sbjct: 578 KFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCG 637 Query: 646 E 646 Sbjct: 638 H 638 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 610 bits (1573), Expect = e-173, Method: Composition-based stats. Identities = 248/658 (37%), Positives = 365/658 (55%), Gaps = 21/658 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+++ EKPS AR IA VL + D VVTW GHLLEQA PDAYD R Sbjct: 1 MRVYLCEKPSQARDIAAVLG--IQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W LA LPI P +W+++ + S Q I L A+E+V A D DREG+++ E++ ++ Sbjct: 59 WALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +VQR ++ L+ +V++A+ L+ ++E L SAL R+RADWL G+N+TRA+ Sbjct: 119 F----KGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ G + G +GV SVGRVQTP L LVV RD +IE+F +FE+ A + F+ W Sbjct: 175 TLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFF--EAGQSFSTKW 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E D+ GR + + + + V ++I+G+ V+ Y KR SE+ PLPFSLS LQ Sbjct: 233 KVPEGAG---DDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKT 289 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FGL AQ VLDI Q LYETHK TYPRSDC +LPEE F +++ A++ ++ Sbjct: 290 CSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQG 349 Query: 361 -QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDA 418 ++D ++ W+ KK+ AHHAIIPT ++ +++NE +VY LI RQYL QF P+ Sbjct: 350 IVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNY 409 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS---KERDEENDGTPLPVVAKGDELLC 475 + + I + I F + GWR L G + + +++ LP + +G L Sbjct: 410 EYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPL 469 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E+ +QT+PP +T+ TL+ AM I + + D LK IL+ G+GTEATRAGII L Sbjct: 470 SHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANL 529 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +RGF+TKKG+ + S+D G+ L +LP+ P +TA WE L +I+E + F + Sbjct: 530 IERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADV 589 Query: 596 VGTLYQLIDQAKRTPVRQFR----GIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGS 649 V + +IDQ K+ P +K K+ Sbjct: 590 VKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQ-CHYWHCKACNQ 646 >UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS155 RepID=A3DB61_SHEB5 Length = 707 Score = 607 bits (1566), Expect = e-172, Method: Composition-based stats. Identities = 236/653 (36%), Positives = 356/653 (54%), Gaps = 21/653 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ IA VL ++GDG G+G VT+C+GH+L+QA+P+ Y+ + Sbjct: 1 MRLFLCEKPSQAKDIASVLG--CKRGDGVF-TGDGIAVTFCVGHVLQQAEPENYNPDFET 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ DLPI+P W++ P Q ++K+ L +A+E++ A D DREG+++ EVL+Y+ Sbjct: 58 WNIVDLPIIPTVWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYV- 116 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +QR ++ L+ ++++A+ LR N E L + L R+R DWL G+NMTR Sbjct: 117 ---NYKGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLC 173 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R GYQG SVGRVQTP L LVV RD ++E F + ++++ F A W Sbjct: 174 TLLSREYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYDITGLFNA--TIPFKAKW 231 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + DE+GR L +HV+++ QP VT ++ KR+ P F L +LQ Sbjct: 232 QVPDNLG---DEQGRCLQVTTVDHVLSQCRDQPGTVTQFDTKRQKSKHPPLFFLGSLQKA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + +FG A+ VLDI Q LYE +K+ TYPR+DC YLP ++++ + V Sbjct: 289 MSAKFGYGAKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVVPAFAAW 348 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFCPDAV 419 D + + CW+DKK+ AHH IIP + + + E E +Y+ I ++YL QF P A Sbjct: 349 CSAADVNETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAE 408 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE-NDGTPLPVVAKGDELLCEKG 478 IEL + A + GWR + G DE +D LP+++ G L + Sbjct: 409 DDATTIELMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDSANLPLLSIGQTLTAQ-F 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 + +++T+PP FT+ TL+ AM+ IA+F D LK IL+ T G+GTEATRA II+ L R Sbjct: 468 QREDKRTKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKAR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 GF+T G+ + S++AG++L +LP++ TRP MTA WE L +I+ DFM Sbjct: 528 GFVTVTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTF 587 Query: 599 LYQLIDQAK------RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 + QL+ K + P + P S + K + Sbjct: 588 ITQLVSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQLSGKNGKFWVCEDKEQC 640 >UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V616_9FIRM Length = 711 Score = 604 bits (1558), Expect = e-171, Method: Composition-based stats. Identities = 285/663 (42%), Positives = 374/663 (56%), Gaps = 22/663 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ RA+A LP PHRKG G+IE G G VVTW GH+L QA+P+ YD R Sbjct: 1 MRLYIAEKPSVGRALATCLPAPHRKGSGWIETGGG-VVTWLFGHVLRQAEPEEYDPALKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+P++W L S +Q V+K + A EIVHAGDPDREGQLLVDEVLD+L Sbjct: 60 WRAEDLPILPKEWHLVVNESAAQQFAVVKGLIARADEIVHAGDPDREGQLLVDEVLDFLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LIN L+ +++ A++ LR N +F+PL +SALARARADWL G+N++RAY Sbjct: 120 ----NTKPVRRILINALDDKSIHDALNDLRDNGDFLPLKLSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGY-QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG+ + VL +GRV+TP L LVVRR+ EIE+F ++ V A T A E F A Sbjct: 176 TLAARRAGHARLVLPIGRVKTPTLALVVRREREIEHFTPATYYLVDALFRTEAGEPFRAR 235 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA--IVTSYNDKRESESAPLPFSLSAL 297 W+PSE P D EGRL+ R A+ PA +VT Y K++ E PLPFSLSAL Sbjct: 236 WKPSEERTPL-DPEGRLVDRAAADAAAASFGEPPADGVVTKYERKKKEEPPPLPFSLSAL 294 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS--VHA 355 Q+ A KR+G Q VLD QKLYE KL +YPRSD YLP ++ ++ Sbjct: 295 QVLAGKRYGYEPQQVLDTAQKLYE-EKLTSYPRSDAEYLPVSQHKDAAKILGNLAALSDT 353 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQF 414 P D ++R W+D K+ AHHAIIPT + LT E +Y LIAR Y+ QF Sbjct: 354 PLAAWAQAADSAKKSRAWNDAKISAHHAIIPTTVPVNLARLTAVERNIYELIARAYIAQF 413 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG------SKERDEENDGTPLPVVA 468 CP+ V+ + E+ F A+ R AGWRT+ E+ + T LP + Sbjct: 414 CPNYVYDQTKAEVTHHGETFTARGRTERTAGWRTMYRAGKNESEDAEKEDEESTVLPPMK 473 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGD E ERQT+PP FT ATLL M I ++V+D+ KK+LR G+GTEATR Sbjct: 474 KGDAAAFVSAETKERQTKPPARFTPATLLQGMKEIHKYVKDEAAKKMLRDVSGIGTEATR 533 Query: 529 AGIIELLFKRGFLTK--KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQC 586 A IIE L +R FL K + + T L +LP+ T PD TA WE L +++ Sbjct: 534 ASIIEDLIRRKFLHAAGKKKVLTPTAEAYLLIDALPDTMTYPDATAIWEDQLHAMADGVG 593 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGS-ADKKKAAPRKRSAKKSPPAD 645 ++F+ L D A+ + GI P G K+K + P Sbjct: 594 TPEEFLAGQAAFARDLCDAARTAQITGGEGIPCPACGRGVMLKRKGKHGDFWGCSAFPQC 653 Query: 646 EVG 648 + Sbjct: 654 RMT 656 >UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=A1TJM5_ACIAC Length = 680 Score = 603 bits (1554), Expect = e-171, Method: Composition-based stats. Identities = 234/666 (35%), Positives = 335/666 (50%), Gaps = 28/666 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+ + EKPS + IA VL R+ + G G VTW IGHL+E A P+AY + R Sbjct: 1 MRVVLCEKPSQGKDIARVLGA--RQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPIVP++W+ + Q V++R L +ASE++ A D DREG+++ E+++Y Sbjct: 59 WSLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R +QR ++ LN ++ +A+ LR++ E +PL ALAR+ ADWL GIN+TR + Sbjct: 119 ----YRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLF 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+LGR AG+ GVLSVGRVQTP L LV RD EI FV F+ ++ + + F+A W Sbjct: 175 TLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLS-AGAQAFSAHW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESAPLPFSLSALQI 299 P D GR L + A+H + A VT + +R E PLPF LS LQ Sbjct: 234 VPP---ATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLPFDLSTLQE 290 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 ++R GL Q LDI Q LYETHK TYPR+D YLPE V+ ++ P L Sbjct: 291 VCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPALQ 350 Query: 360 P-QPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 P +D R+R W+ K+ AHHAIIPT + ++E E VY LI YL QF P Sbjct: 351 PLMQRLDLGQRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLPH 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL-------------GSKERDEENDGTPL 464 + + ++ L A + + +AGW+ ++ E L Sbjct: 411 YAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQAL 470 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + +G ++ T+ P +T L+ AM +A+ V D LK+ LR T G+GT Sbjct: 471 PTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIGT 530 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 EATRA II L RGFL +KGR + ++ L ++P P TA WE L I + Sbjct: 531 EATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEAR 590 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 F+ + QL++Q + +R G P G + K+ + Sbjct: 591 TMDLDTFVSKQAAWVSQLVEQHREATLAIRVPAGPPCPLCGAATRKRTGKTGAFWSCSRY 650 Query: 643 PADEVG 648 P + Sbjct: 651 PDCKGT 656 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 602 bits (1552), Expect = e-170, Method: Composition-based stats. Identities = 207/654 (31%), Positives = 320/654 (48%), Gaps = 54/654 (8%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA VL ++ G +VTW +GHL+E P+ YD +Y Sbjct: 1 MKSLVLAEKPSVARDIARVLG--CKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYE 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W L DLPI+P+K L+ + Q I+R +++ A D REG+L+ +L+ Sbjct: 59 TWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILE 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + + + R I+ +A+ +L+ ++F L SA+ RA ADWL G+N++ Sbjct: 119 MIGWT----KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVS 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS GRVQTP L +++ R+ EI++FV ++ ++A I T Sbjct: 175 RALTTK-----YNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKI-----GSIT 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A+W+ L + A+ ++ R+ GQPA V S KR+SE APLP+ L+ L Sbjct: 225 AVWERHGGHR--------LFDQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDLTEL 276 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q +A KRFG SA+ L + Q+LYE HKL+TYPR+D RYLP + A + A+ D Sbjct: 277 QRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGYED 336 Query: 358 LLPQPV--VDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQF 414 ++ + R ++D KV HHAI+PT + L+ +E K+Y+LIAR++L F Sbjct: 337 VIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFLALF 396 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P DI FVAK + G++ +LG +E D + L +A+G L Sbjct: 397 FPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLGKEETDAK---PTLSHLAEGQTLP 453 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 + E + T+PP +++A LL+ M GLGT ATRA IIE Sbjct: 454 SVQLEREQSFTEPPARYSEADLLAQMEK-----------------YGLGTPATRADIIER 496 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 L + + +K + T GK L + E P++TA WE L I+ + Q F+ Sbjct: 497 LVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQFLAN 556 Query: 595 LVGTLYQLIDQAKRTPV----RQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + QL+ + K++ + P G ++K + + Sbjct: 557 IRRQTQQLVAEIKQSEQVYKAPNLTNLTCPECGALLKERKTKDGRMLVCSNLAC 610 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 601 bits (1549), Expect = e-170, Method: Composition-based stats. Identities = 212/664 (31%), Positives = 341/664 (51%), Gaps = 43/664 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L I EKPS+ + IA VL + DG++E +V+W GHL+E A P YD + Sbjct: 1 MKTLVITEKPSVGKDIASVLGR-FESKDGYLE-NEKYIVSWAFGHLVELADPSVYDPVFK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVT-KQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVL 116 +W+LA LPI+P+ ++L + KQL +K+ L+ E S++V+ D REG+ + + Sbjct: 59 KWDLATLPIIPDSFKLVEIAGSSAKQLRTLKKLLNSAEVSQVVNGCDAGREGESIFRRIY 118 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + R+ ++R +++ P AV+ A LR E+ L +A AR +ADWL G+N Sbjct: 119 HFCGC----RKPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEARGQADWLVGLNG 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA+T+ + VLSVGRVQTP L L+V R+ EI NFV ++EV T + Sbjct: 175 TRAFTVR-----HGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQTDNGM-Y 228 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLS 295 W ++++E RL +R A ++ ++S + V S K E F+L+ Sbjct: 229 KGKW--------FREKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNLN 280 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQ E +R+G +AQ VLDI Q LYE HKL+TYPR+D R+L + + + Sbjct: 281 DLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNAP 340 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLIARQYLMQF 414 P P + R DD K+ HHAIIPTA L++ E K+Y+L+ R++L F Sbjct: 341 KYAELIPDTLPGLSKRYVDDGKITDHHAIIPTAVDPSKAQLSDQEKKIYDLVVRRFLSIF 400 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-------EENDGTPLPVV 467 P+A + + + A F ++ R AGW+ + +++ ++ + LP + Sbjct: 401 YPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQALPPL 460 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G + K E++E+QT+PP+ FT+AT+L+AM +FV+DK++ ++L+ T G+GT AT Sbjct: 461 TQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIGTPAT 520 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RA IIE L K G++ + + + T G+ L +P+ ++TA WE L ++ E Q Sbjct: 521 RAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPKQLKSVELTASWEDGLRRVEEGQQN 580 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGGSADKKKAAPRKRSAKKS 641 ++Q + +L+ A+ V Q G P G + + Sbjct: 581 AALWIQDIQAYTRELVVLARNQEVSQGVGTARDTLGKCPVCGRDVVETAKSY----GCSG 636 Query: 642 PPAD 645 Sbjct: 637 YKEG 640 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 600 bits (1547), Expect = e-170, Method: Composition-based stats. Identities = 212/694 (30%), Positives = 349/694 (50%), Gaps = 72/694 (10%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR +++VL KG+G++E + ++TW IGHL+ A+PD YD+ Sbjct: 1 MKQLVLAEKPSVARDLSNVLGN-FNKGNGYLES-DAYIITWAIGHLVTLAEPDDYDAALK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 +W L LPI+P +++L+P + KQ N++K LH +I+ A D REG+L+ + Sbjct: 59 KWFLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGELIFRYIYK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + +R +++ P AV + D LR ++ L +A AR++ADWL GIN T Sbjct: 119 LTDCQ----KPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA+T+ + +LSVGRVQTP L L+V R++EI FV + ++E+ A + + Sbjct: 175 RAFTVK-----HNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYI 229 Query: 238 AIWQPSEACEPYQDE--------------------------------------------- 252 W E E Sbjct: 230 GKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAM 289 Query: 253 EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNV 312 + + R A + +++GQP V S K E PL F+L+ LQ EA K+FGLSA Sbjct: 290 QTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKT 349 Query: 313 LDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDI---R 369 L + Q+LYE+ KLITYPR+D R + E + A++V A ++ Sbjct: 350 LSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKERKAFLN 409 Query: 370 NRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELD 428 R +D KV H A+IPT ++ L+ +E +VY+L+ R++L F P A + + + + Sbjct: 410 KRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITE 469 Query: 429 IAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQP 487 + + F+++ R + GW+T+ +++ +++ LPV+ + +L K ++ E++T P Sbjct: 470 VKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNP 529 Query: 488 PRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY 547 P+ +T+A LLS M G R + D++LK+ +R + GLGT ATRA IIE L K G++ ++ + Sbjct: 530 PKRYTEAALLSVMEGAGRLLNDEELKEAMRGS-GLGTPATRAAIIERLLKVGYIERRKKT 588 Query: 548 IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK 607 + T+ G+ L +PE P+MTA WE L I + Q +FM ++ Q+++ A+ Sbjct: 589 LLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELAR 648 Query: 608 RTPVRQF-------RGIVAPGSGGSADKKKAAPR 634 R P G + + Sbjct: 649 RQKTEGEPLRNNRDIIGKCPLCGRPVVEYPKSYS 682 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 600 bits (1547), Expect = e-170, Method: Composition-based stats. Identities = 233/673 (34%), Positives = 356/673 (52%), Gaps = 36/673 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L+I EKPS A+ +A V+ K ++GDGF+ G +V+TW GHLLE PD YD RY Sbjct: 1 MDLYICEKPSQAKDLAGVM-KASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI PE W+ R S KQ +++ + +AS I + D DREG+ + +LD + Sbjct: 60 WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++R + L+ ++++A++ ++ + V L +ALAR RADWL G+N++R Y Sbjct: 120 ----YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+L R+ G+ L VGRV TP + LV +RD EI F ++ + ++ + F A W Sbjct: 176 TVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQ-FAAQW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P E C DE+GR +++ AE V ++++G A+++ K ESAPLPF L++LQ Sbjct: 235 IPPEECS---DEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLPFDLTSLQQY 291 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+KR+G +AQ VLD Q LYETHK TYPR+D RYLPE ++ A+ + ++ Sbjct: 292 ASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSG 351 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDA 418 DP + R ++D KV AHHAIIPT R+ ++E E +Y+ I R Y+ QF + Sbjct: 352 LVAGADPHRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEF 411 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKER----------DEENDGTPLPVVA 468 F K IE+ + F + + + GW+ L S D + LP V+ Sbjct: 412 EFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVS 471 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L E+ + T+P HFT+ATLL+AM IARFV ++ K+IL+ T GLGT ATR Sbjct: 472 QGEPALLNGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATR 531 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A II+ +G+ ++ + + +TD AL LP P MTA WE L +++ Sbjct: 532 ASIIQGAVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNM 591 Query: 589 QDFMQPLVGTLYQLIDQ---------------AKRTPVRQFRGIVAPGSGGSADKKKAAP 633 FM+ + + Q+++Q AK + GG + K Sbjct: 592 SVFMKQISTWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKN 651 Query: 634 RKRSAKKSPPADE 646 ++ + Sbjct: 652 GFFWGCQNEACKK 664 >UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_9FIRM Length = 821 Score = 597 bits (1539), Expect = e-169, Method: Composition-based stats. Identities = 255/670 (38%), Positives = 373/670 (55%), Gaps = 28/670 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+ R +A L P + DG++ +G VVTW GH+L QA+P+ YD +Y R Sbjct: 1 MRLYIAEKPSVGRELAKCLTGPVTRRDGYLVTKDG-VVTWLFGHILRQAEPEEYDPKYKR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W DLPI+PE W+L KQ ++K + +A EIVH GDPDREGQLLVDEVLDYL Sbjct: 60 WRADDLPIIPEHWKLFVDKDCEKQFAIVKSLIEKADEIVHGGDPDREGQLLVDEVLDYLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ V+R L+N L+ +++++A LR N +F L SALARARADWL G+N++RAY Sbjct: 120 ----NKKPVRRILLNALDEKSIKKANASLRDNRDFFNLKQSALARARADWLIGMNLSRAY 175 Query: 181 TILGRNAGYQG-VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ R AG++ VL +GRV+TP L LVVRR+ EIE+F ++ ++ F A Sbjct: 176 TLAARRAGHERLVLPIGRVKTPTLSLVVRREREIEHFKPVTYYLIRGTFQHENG-SFEAQ 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP--AIVTSYNDKRESESAPLPFSLSAL 297 W+P + D E RL+ + +A+ + P A++++Y ++ E PLPFSLS L Sbjct: 235 WKPKDTMAGL-DSENRLIDKKIADEKLAFFEELPHDAVISAYQKAKKQEPQPLPFSLSTL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A KRFG + Q VLD QKLYE KL TYPRSDC YLP +++ ++ Sbjct: 294 QVLAGKRFGYAPQLVLDTAQKLYE-KKLTTYPRSDCEYLPTNQLGEAATILSHLAKAGDA 352 Query: 358 LLPQ--PVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQF 414 + +P ++R W+DKK+ AHHAIIPT + +T+ E +Y+LIAR YL QF Sbjct: 353 QVAAWVKAANPKQKSRAWNDKKISAHHAIIPTTVQADVTKMTQEERNLYHLIARAYLAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE-----------ENDGTP 463 P + + +E+ F A R + GW+ + S+++ + E Sbjct: 413 YPVHTYDQTKVEVQYKDETFTASGRTERDLGWKVMYQSQKKKQESDEEDDKEDKEESAKT 472 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + K D + ++G ++E+ T+PP FT +TLL+ M I ++V++ + KK L+ G+G Sbjct: 473 LPAMKKKDAVAWQRGRMLEKMTKPPTRFTASTLLAGMKEIHKYVKNPEAKKQLKDVYGIG 532 Query: 524 TEATRAGIIELLFKRGFL--TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 TEATRA II+ L +R F+ K +Y+ T A L +LP+ T PD TA WE L + Sbjct: 533 TEATRATIIDDLIRRKFMKAEGKKKYLVPTPAAYLLVDALPDELTYPDSTAIWEDKLHSM 592 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSAD-KKKAAPRKRSAKK 640 SE + DF+Q + +L +A + V P K+K Sbjct: 593 SEGEGSLADFLQGQIAFTRKLCAKATDVHMEVKGENVCPRCHQGVLTKRKGKNGVFWGCS 652 Query: 641 SPPADEVGSG 650 + P + Sbjct: 653 NYPKCRMTCN 662 >UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii LLAP12 RepID=C6N6E9_9GAMM Length = 668 Score = 595 bits (1534), Expect = e-168, Method: Composition-based stats. Identities = 237/659 (35%), Positives = 353/659 (53%), Gaps = 23/659 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFI EKPS A+ IA VL R F GN VTWC+GHLLE A PD Y Sbjct: 1 MRLFICEKPSQAKDIATVLGATTRTDACF--EGNEIAVTWCVGHLLELAPPDHYCDSIKP 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W + LP+VP++W L P+ KQLN I + L +A +V A D DREG ++ EVLDY Sbjct: 59 WRMEVLPVVPKQWVLMPQEKTKKQLNAIGKLLKQARSVVIATDADREGDVIGREVLDYF- 117 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R ++ L+ +++++A+ ++ + L + L R RADWL G+N+T A Sbjct: 118 ---NYQGPVERLWLSALDEESIKKALHSIKPGAATECLYQAGLGRQRADWLMGMNLTMAV 174 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L G QGVLSVGRVQTP L LVV RD IE F A+D++ +KA E F W Sbjct: 175 SSLYALPG-QGVLSVGRVQTPTLKLVVDRDLGIEQFKAQDYYVLKALCENINQEPFWVTW 233 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 E E D++G+ + + + V +I+G+ VTS+ + + E+ PL SLS+LQ Sbjct: 234 ---EIPEELSDDDGKCIQKASIDEVARKINGKAGRVTSFKELDKREAPPLCLSLSSLQQL 290 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A+ + GLSA++ LDI Q LYE HK +YPR+DC YLP+ FA AV +A+ P++LP Sbjct: 291 ASSQLGLSAKHTLDIAQALYEQHKATSYPRTDCGYLPDSQFAEAGAVFDALKQIDPEVLP 350 Query: 361 Q-PVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 ++++ W+ K+ AHH IIPT + + +TE+E VY LI YL QF + Sbjct: 351 LIERCSLQLKSKAWNSDKITAHHGIIPTLNPKVNLKTMTESERNVYQLIRAYYLAQFLGE 410 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-----GTPLPVVAKGDE 472 F + + LDI F A A GW++ + EE + +P + + Sbjct: 411 YEFVQRQVTLDIEAYTFKASAHLPGVLGWKSAIKPIRDLEEEELDTDASESIPKLHDQEP 470 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + R+T+P FT+ +L++AM IA ++++ LKKIL+ T G+GTEATRA I+ Sbjct: 471 VSIQKLKPDSRKTKPKSRFTEGSLIAAMKSIANYIENPQLKKILKETSGIGTEATRANIL 530 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E L R +L ++G+ + ST G+ L LP+ T P TA WE +L I+ + DF+ Sbjct: 531 ETLLSRAYLKRQGKQLISTPKGRELIQRLPQSITNPATTALWEQMLEDIALGKHALDDFL 590 Query: 593 QPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + TL ++ Q ++ P + K++ + P + Sbjct: 591 EEQSDTLSGMLVQLEKQKPASHILGSNSTYSCPDCQKTLMKRQGSKGAWWGCSGYPQCK 649 >UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QVL1_CHRSD Length = 654 Score = 594 bits (1531), Expect = e-168, Method: Composition-based stats. Identities = 299/647 (46%), Positives = 397/647 (61%), Gaps = 18/647 (2%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPSLARAIAD LP ++ +G++ CG ++WC+GHLLEQA PDAYD+RY + Sbjct: 1 MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGET-CISWCVGHLLEQAPPDAYDARYQQ 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPIVP +W+L PR QL VI++ L A +VHAGDPDREGQLLV +V+ +L Sbjct: 60 WRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R + R L++DLN AV +A+ + N+ + L +A AR+RADW+YGIN++RA+ Sbjct: 120 W----RGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAW 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ GR AGYQGVLSVGRVQTPVLGL+VRRD +IE F + F+ + A + A W Sbjct: 176 TLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVEHG-TLRAWW 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 QP DE+GRLL R AE + + G ++ KR+++SAPLP+SLSALQ++ Sbjct: 235 QPQAPHPL--DEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVD 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL-L 359 AA+R+ L A+ VLDICQ LYE H+LITYPRSDCRYLPE HFA ++ L Sbjct: 293 AARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRG 352 Query: 360 PQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCPDA 418 D R+R W+DK+V AHHA+ PT R+ A LT +EA V+ LIAR L QF Sbjct: 353 WYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPL 412 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V R I F A+ R + E GW+ L +++ + PLP + +G+ Sbjct: 413 VTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTRD-----EAPPLPALHEGEAARVVDC 467 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 V +RQT+PP FTDA+L+ AM IAR+V D +K+ LR TDGLGTEATRAGI+E L R Sbjct: 468 AVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTR 527 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGT 598 G++ ++ + +T G+AL +LP+ ATRP+ TA WE L I+E + F+ LVG Sbjct: 528 GYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGD 587 Query: 599 LYQLIDQAKRTPVRQ---FRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 + QL+DQA +RQ G P S K+ A SP Sbjct: 588 VRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSP 634 >UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepID=B2RH95_PORG3 Length = 710 Score = 593 bits (1530), Expect = e-168, Method: Composition-based stats. Identities = 210/659 (31%), Positives = 334/659 (50%), Gaps = 35/659 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+ R IA VL + G++E GNG VTW GHL +P Y + R Sbjct: 36 MIVCIAEKPSVGREIAAVLGA-TKAYKGYME-GNGYQVTWTFGHLCALKEPHDYAPEWKR 93 Query: 61 WNLADLPIVPEKW--QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+++ LP++P ++ +L S+ +Q I++ +HEA +V+ GD +EG+L+ VL Sbjct: 94 WSISSLPMIPLRFGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDAGQEGELIQRWVLQK 153 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 V+R I+ L +++ RLR + EF L + LARA DWL G+N TR Sbjct: 154 TGCT----CPVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAIGDWLLGMNATR 209 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ + + VLS+GRVQTP L L+VRR EIE+F + ++EVK Sbjct: 210 LYTLRFGS--NRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVKTIYRD-------- 259 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + +GR A V ++G P VTS K+ E P F L+ LQ Sbjct: 260 --------TVFNATKGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLTGLQ 311 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +E KRF ++A L Q LYE K+ +YPR D YL ++ F ++ +S + Sbjct: 312 VECNKRFAMTADATLRTIQSLYE-KKITSYPRVDTTYLSDDVFEKVPNILQGLSDYTLLT 370 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 P + +D+ K+ HHAIIPT + + ++E+E +V++L+AR+++ F PD Sbjct: 371 APLRSSKLKKSKKVFDNSKITDHHAIIPTGQ-PSHGMSEDERRVFDLVARRFIAVFYPDC 429 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE----NDGTPLPVVAKGDELL 474 +F + + AK +F + + E GWRT+ + D++ ++ LP+ ++G+ Sbjct: 430 IFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFSEGESG- 488 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 EV E+ TQPP+ +T+ATLL AM + V+D++L+ L+ +G+G +TRA IIE Sbjct: 489 VHTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKE-NGIGRPSTRAAIIET 547 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LFKR ++ K+ + + +T G +L ++ E+ ++T WE L +I DF+ Sbjct: 548 LFKRNYIYKEKKNLKATPTGMSLIATIDYELLKSAELTGQWEYKLRRIERGDYSAADFIN 607 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 L L LI ++ P + + KKK A + + G G I Sbjct: 608 ELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADKPMQKQLDLTCPVCGKGII 666 >UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ferrooxidans RepID=B7JBJ6_ACIF2 Length = 699 Score = 593 bits (1529), Expect = e-168, Method: Composition-based stats. Identities = 266/655 (40%), Positives = 373/655 (56%), Gaps = 28/655 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L+IAEKPSL + IA+ LP KG+GFI+CG VVTWC GH+ EQ +PD Y Sbjct: 1 MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVP 60 Query: 59 ------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 +W +LPI PE+W+ + + Q+ VI+ L +AS +V+AGDPDREGQLLV Sbjct: 61 TTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLV 120 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL+ L+ + R + L+ Q+V +A+ L+ N ++ L SA ARARADWL Sbjct: 121 DEVLEELRW----KGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLM 176 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T+ AG V+SVGRVQTP L LVV RDE+IE+F KD++ V Sbjct: 177 GMNLTRAFTLRNSGAG---VVSVGRVQTPTLALVVARDEKIEHFKPKDYY------VPRI 227 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLP 291 + F A W+ E E D EG L R A+ + +R + A V + + + APL Sbjct: 228 NAGFWATWELREDFEGV-DAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLG 286 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 FSL+ LQ + + G+SAQ+VLD Q LYE HK TYPR+DCRYLPEE +++ + Sbjct: 287 FSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGL 346 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 + L + D + ++ W+ KV AHHAIIPT +++ AKVY++I R YL Sbjct: 347 AKAGFADLVKA-ADSNRKSAIWNTGKVTAHHAIIPTGSM-QGSMSPAVAKVYDIIVRSYL 404 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVAKG 470 QF P V+R L + A A AGW+ + G + D ++ P+P + KG Sbjct: 405 AQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKG 464 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 L + +V +QT+PP FTD +L+ AM+ I + V+D+ K L+ T GLGTEATRA Sbjct: 465 QVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRAS 524 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQD 590 IIE L RGFL +KG+ I ST AG+AL H+LP+ T P +TA WE L+ +SE + Q Sbjct: 525 IIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVTLQQ 584 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 F + + ++I+ AK T V + P SG K + +K+ PA Sbjct: 585 FEEAQRKFVVRMIEAAKATTVAVGQAR--PTSGAGRGKSSTGKTRGVGQKTGPAC 637 >UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LL88_HALO1 Length = 867 Score = 592 bits (1527), Expect = e-167, Method: Composition-based stats. Identities = 230/679 (33%), Positives = 350/679 (51%), Gaps = 49/679 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IA V+ ++ +G++E G G V+WCIGHL E +P YD+++ W+ Sbjct: 6 LIIAEKPSMARDIARVVGARSKR-EGYLEGG-GYWVSWCIGHLAELCEPHEYDAKWKSWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRF--LHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P++ +++P S L V+ R E IV+A D REG+L+ V Sbjct: 64 PSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHV----H 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ V+R I+ L +A+ R + LR +EF L +A ARA ADWL G+N TRA Sbjct: 120 ALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRAL 179 Query: 181 TILGRNAGYQGVL-SVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA--DERFT 237 T L R+ G +G+L SVGRVQTP L L+VRR+ EIE+F +K F++V A P + Sbjct: 180 TGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYE 239 Query: 238 AIWQPS------------------------EACEPYQDEEGRLLHRPLAEHVVNRISGQP 273 IWQ + + R+ R A+ + + + G+ Sbjct: 240 GIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRA 299 Query: 274 AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDC 333 +T K E PL F L+ LQ A +RF +SA+ L++ Q LYETHKLITYPR+D Sbjct: 300 GTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDA 359 Query: 334 RYLPEEHFAGRHAVMNAISVHAP---DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS 390 RYL ++ ++ A++ P D R +D+ +V HHAIIPTA++ Sbjct: 360 RYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKA 419 Query: 391 SAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL 449 + L+ +E ++Y+LIAR++L PDAV+ + I +A F + R AE GW+ Sbjct: 420 PSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQA 479 Query: 450 LGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQD 509 + + PLP + + E+ EV E +TQPP+ +++A+LL AM R + D Sbjct: 480 EPP--PPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDD 537 Query: 510 KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRP 568 L++++R GLGT ATRA IIE L KR ++ ++GR + T+ G+AL S+P E Sbjct: 538 PGLRRVMRDA-GLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSA 596 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT------PVRQFRGIVAPGS 622 ++TA WE L I+ + FM + G + +++D + + P Sbjct: 597 ELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGLCPVC 656 Query: 623 GGSADKKKAAPRKRSAKKS 641 G + + S K Sbjct: 657 NGVVTEGFKTFQCASGKSC 675 >UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_9BACT Length = 817 Score = 590 bits (1522), Expect = e-167, Method: Composition-based stats. Identities = 198/688 (28%), Positives = 320/688 (46%), Gaps = 72/688 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L ++G GF+E GNG VTW GH++E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHLGA-TKRGVGFLE-GNGWAVTWAFGHMVELQEPEDYKPEWKA 58 Query: 61 WNLADLPIVPEKWQLQPRPS-----VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L+ LPI+P + L+PR S QL IK+ +A EI+ A D REG+L+ + Sbjct: 59 WRLSTLPIIPADFALRPRASDPDGTARAQLETIKKLFLDADEIICATDAGREGELIFRYI 118 Query: 116 LDYLQL---APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 + P + V+R I+ L +A+E+ L S++ L +A R+ ADW+ Sbjct: 119 YTWTGCEALPPPLAKPVRRLWISSLTNEAIEKGFQNLAPGSDYDRLYHAARCRSEADWIV 178 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N TR +T+ +LS+GRVQTP+L ++V RD ++E+F +DF+EV + Sbjct: 179 GLNATRFFTVEYGRR--NLLLSLGRVQTPILAMIVGRDLDVEHFKPEDFWEVHTLCRSA- 235 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 ++ G+ + A+ +V+RI+G ++ + K PL + Sbjct: 236 ---------------TFKHTAGKFTVQTEAQAIVDRITGHELVIKNVTKKNALTHPPLLY 280 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 L+ LQ + KR GL+A L + Q LYE+ L TYPR+D YL + +++ + Sbjct: 281 DLTGLQRDMNKRHGLTADQTLRLAQSLYESKHL-TYPRTDSCYLSTDIQPTIGPLLDRLR 339 Query: 353 VHAPDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 P + + R DDKKV HHAIIPT +LT +EAKVY+ + + + Sbjct: 340 ALKPAEIGKLDTGALAFSKRIIDDKKVSDHHAIIPT-NVLGGDLTGDEAKVYDAVLTRLI 398 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE------------- 458 F P + +E + A F A+ L + GW+ L G D++ Sbjct: 399 AVFYPPCIKAVTTVEAESAGEPFRARGTVLVDPGWQALYGGDVSDDDAGTGTKAKKASKN 458 Query: 459 ----------------------NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATL 496 + LP +G+ + + + +T P+ F +A+L Sbjct: 459 AAKKDADENESGESDAKDSDAADSAQQLPDFQEGER-NPHEPSLPQFKTSAPKRFNEASL 517 Query: 497 LSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA 556 L M + V D+ LK+ L+ G+GT ATRA IIE+L RG++ +K + + STD+G+A Sbjct: 518 LQLMETAGKIVTDETLKEALKDK-GVGTPATRAAIIEVLITRGYVERKKKNLISTDSGRA 576 Query: 557 LFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR 615 L + E P++T WE L QI + + FM + +++ + Sbjct: 577 LISLVQDERLKSPELTGDWEYRLRQIERGEYEPRVFMSEVEAYTREILKNRAEQTINLSN 636 Query: 616 GIVAPGSGGSADKKKAAPRK---RSAKK 640 P + + R K Sbjct: 637 LGPCPACHAPVMRGRTGYGCSQWRGGCK 664 >UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C314B9 Length = 754 Score = 588 bits (1517), Expect = e-166, Method: Composition-based stats. Identities = 196/651 (30%), Positives = 331/651 (50%), Gaps = 28/651 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+ R ++ VL P R+G+GF+E G ++TW +GHL++ A+PD YD ++ RW Sbjct: 5 LVIAEKPSVGRDLSRVLAGPFRRGEGFLE-GPDHILTWAVGHLVQLAEPDEYDDKFKRWR 63 Query: 63 LADLPIVPEKWQLQPRPSVTK-QLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 +ADLPIVPEK++L R +K Q+NV+KR L +V+A D REG+L+ + + Sbjct: 64 MADLPIVPEKFRLVVRDERSKRQMNVVKRQLGRDDIGVVVNACDAGREGELIFAYLYEKA 123 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR ++ + A+ A +LR +E L +A +R+ ADW+ G+N TRA Sbjct: 124 G----SRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDAARSRSEADWIVGMNSTRA 179 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 TI R++ G +S+GRVQTP L ++ RR+EEI F + ++ V A + + Sbjct: 180 ATIRLRSSF-DGAVSLGRVQTPTLAILARREEEIRAFRPEPYWTVDATFAASGERVYDGR 238 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + + + A VV G ++T ++ E PL + L++LQ Sbjct: 239 FHVTAGSGDGRGPR--IGSAEFAAAVVEACRGTDGVITKLEKRKRRERVPLLYDLTSLQR 296 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A RFG SA+ L Q+LYE HK +TYPR+ RYLP + + + + Sbjct: 297 DANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEIKPIAEIVGGRSEYAA 356 Query: 360 PQPV---VDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 +D R +D +V HHAIIPT ++ + +++ ++Y+L+A+++L F Sbjct: 357 GARYVLGLDVLPLARVVNDARVTDHHAIIPTRAPHPVDRMGDDDRRIYDLVAKRFLAVFH 416 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE-------NDGTPLPVVA 468 PDA F +E ++A F + + + GWR + G E LP + Sbjct: 417 PDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYGESADAEPREGEEDEGREQQLPKLE 476 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+++ + +++T+PPR +++ +LL+AM + V +++L++ ++ + G+GT ATR Sbjct: 477 QGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEEELREAMKDS-GIGTPATR 535 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQCR 587 A IIE L G++ + GR + T+ G + L T P +T WE L +I + Sbjct: 536 AAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGHPLTSPSLTGDWEHRLGKIELNEDS 595 Query: 588 YQDFMQPLVGTLYQLIDQ----AKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 + FM +V + + + + + P G + + Sbjct: 596 RRAFMADIVKFAESTVAELDAKLRDVRIPRANLGPCPVCGHDIMENRKGFS 646 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 586 bits (1512), Expect = e-166, Method: Composition-based stats. Identities = 200/672 (29%), Positives = 317/672 (47%), Gaps = 65/672 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+A+ IA VL + + G VVTW +GHL+ A+P+ YD +Y Sbjct: 1 MKSLVLAEKPSVAKEIARVLGCSSK--NKSYMEGPDYVVTWALGHLVTLAEPEDYDPKYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 WNL DLP++P K L+ + Q + + E++ A D REG+L+ +++ Sbjct: 59 TWNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIATDAGREGELVARWIME 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + R+ +R I+ +A++ L+ ++ L SA+ RA ADWL G+N+T Sbjct: 119 LVHW----RKPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVCRAEADWLIGLNVT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y L+ GRVQTP LG ++ R++EI F ++ ++ V A + F Sbjct: 175 RALTVK-----YNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAEL-----GAFQ 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A+W+ ++ + +GR+ R AE V+ R+ G+ A V ++SE P F L+ L Sbjct: 225 ALWRQND------NHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLTEL 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA KR G SA+ ++ QKLYE HKL+TYPR+D RYL + + +++V Sbjct: 279 QREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGPYA 338 Query: 358 LLPQPVVDP--DIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQF 414 L + ++ + R DD KV HHAIIPT + L+ +E K+Y+LI R+++ F Sbjct: 339 PLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYVNLSALSNDERKLYDLIVRRFIALF 398 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS-------KERDEEND------- 460 P + + + L + + K AK + + GW+ L G E DEE + Sbjct: 399 YPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGRGEDKS 458 Query: 461 --GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 LP + +G + ++ + E +T PP +T+A+LLS M Sbjct: 459 TPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEK---------------- 502 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 GLGT ATRA IIE L + + + T GK L + + P++TA WE L Sbjct: 503 -HGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVDELRSPELTAKWEREL 561 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLI----DQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 I+ Q + FM + + + ++ K P G + K Sbjct: 562 ELIAHGQGDAKRFMAGIREQANKWVTAVKNETKEYKPHNLTHSRCPECGKLLMEVKGKRG 621 Query: 635 KRSAKKSPPADE 646 K Sbjct: 622 KSLVCSDRECSY 633 >UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_9BACT Length = 781 Score = 586 bits (1511), Expect = e-166, Method: Composition-based stats. Identities = 202/657 (30%), Positives = 323/657 (49%), Gaps = 44/657 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ +AEKPS+AR IA L K ++ DG++E GNG VTW GHL+E +P+ Y + Sbjct: 1 MKVVLAEKPSVARDIAKHL-KAGQRHDGYLE-GNGWAVTWAFGHLVELKEPEEYRPEWKS 58 Query: 61 WNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W ++ LPIVP++++L+ R KQL +K+ EA EI+ A D REG+L+ +L++ Sbjct: 59 WKVSLLPIVPDQFELRARGDDGAKKQLETVKKLFGEAEEIICATDAGREGELIFRYILEW 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R I+ L A+ + +LR +F L +A R+ ADW+ G+N TR Sbjct: 119 SGCEA---KPVKRLWISSLTGAAISKGFAKLREGKDFDTLHYAARCRSEADWIVGMNATR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +T+ +LS+GRVQTP+L ++V RD EIENF ++DF+E+ Sbjct: 176 YFTVEYGKR--NLLLSLGRVQTPILAMIVGRDMEIENFKSEDFWELHTECRD-------- 225 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 ++ G++ A+ + ++ GQP +V+ K E+ + PL F L+ LQ Sbjct: 226 --------TKFRHTGGKIQKEEEAKALFEKVDGQPLVVSDVQQKNENTNPPLLFDLTELQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH-APD 357 E +R+G +A L I Q LYE K ITYPR+D RYL + ++ + + Sbjct: 278 REMNRRYGFTADQTLRIAQNLYE-QKRITYPRTDSRYLSTDLQPTIGPLLERLKAIKEKE 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 + P + R DD KV HHAIIPT NL +E +VY+ I + + F P Sbjct: 337 IAPLELDKLSFGKRIVDDSKVSDHHAIIPTDDLPR-NLNADEERVYDAILVRLIAVFYPA 395 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----------SKERDEENDGTPLPVV 467 V +E ++ F A+ L EAGW+ L + + +P Sbjct: 396 CVKAVTTVEAKASEETFRARGTVLLEAGWQALYPQLFAIASKKKGAKGKAAPEPAAMPHF 455 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G+ + + + +T PP+ FT+ATLLS M + V+D++LK+ L+ G+GT AT Sbjct: 456 QVGES-NPHRPSIEKFKTNPPKRFTEATLLSLMETAGKIVEDEELKEALKDK-GVGTPAT 513 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQC 586 RA IIE+L +R ++ +K + + ST +G+ L + E P++T WE L ++ + Sbjct: 514 RASIIEVLIQRKYVERKKKNLISTYSGRHLISLIQDERLKSPELTGDWEFRLKKVERGEQ 573 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRK---RSAKK 640 + FM +V +++ V P + R K Sbjct: 574 DPKAFMSDVVEYTKEILANDAEKTVDLKNLGPCPKCSAPVMRGNTGYGCTRWREGCK 630 >UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organisms RepID=A5FHK0_FLAJ1 Length = 768 Score = 584 bits (1505), Expect = e-165, Method: Composition-based stats. Identities = 192/651 (29%), Positives = 325/651 (49%), Gaps = 33/651 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA VL K DG+ E GNG VT+ GHL +P+ Y + Sbjct: 1 MKVCIAEKPSVAREIASVLGANT-KHDGYYE-GNGYAVTYTFGHLCTLKEPNDYKPHWKS 58 Query: 61 WNLADLPIVPEKWQLQPRPSV--TKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L +LP++PEK++ + + KQ +IK +A +++ GD +EG+L+ V++ Sbjct: 59 WDLNNLPMLPEKFETKVVQNSGIQKQFKIIKTLFDKAELVINCGDAGQEGELIQRWVMNE 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + +++R I+ L +A++ D L+ + + L + +RA DWL G+N TR Sbjct: 119 AH----YKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAIGDWLLGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ ++ GY+ VLS+GRVQTP L +VV R +EIENF + ++E++ Sbjct: 175 LYTV--KHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQTLYR--------- 223 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + EEGR L + E + ++ + S + K +E AP F L+ LQ Sbjct: 224 -------ETLFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLTGLQ 276 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++FG SA+ L I Q LYE K ITYPR D +LP + + ++ ++ ++ Sbjct: 277 VYCNQKFGFSAEETLKIAQTLYE-QKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSHLT 335 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 P + ++DKKV HHAIIPT INL N+ +VY++I +++L F D Sbjct: 336 EPLLGKKIKKSPKVFNDKKVTDHHAIIPTGI--EINLPYNQQQVYDIIVKRFLAVFYDDC 393 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + + A F A + + + G+R + E+ LP G++ + Sbjct: 394 LVANTTVIGKAADVTFKATGKEILKKGFRVVFEDPNAKEKEPD-LLPSFVVGEKG-PHEP 451 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 ++++T+PP HFT+ATLL AM + V D+DL+++++ +G+G +TRA IIE LFKR Sbjct: 452 SFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKE-NGIGRPSTRANIIETLFKR 510 Query: 539 GFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVG 597 ++ + + + T G L ++ E+ ++T WE L I + F++ + Sbjct: 511 QYIVRNKKQVLPTTTGIQLIDTIQNELIKSAELTGSWEKQLKDIEKGTFTAAAFIRNMKR 570 Query: 598 TLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 + L+ + + A + +K A+ P + Sbjct: 571 MVEALVTEVRSETRHANISHAATIQKPAVKAEKKKAAGILAETCPKCQKGN 621 >UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BLQ5_VEIPT Length = 773 Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats. Identities = 264/710 (37%), Positives = 377/710 (53%), Gaps = 68/710 (9%) Query: 1 MRLFIAEKPSLARAIADVLP--KPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MRLFIAEKPS+AR I+ LP K +K +G+ G+ VVTW +GH+L QA+P YD +Y Sbjct: 1 MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDD-VVTWVVGHVLHQAEPGDYDDKY 59 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 RW DLPIVP +W+L S +Q ++K + +A IV+AGDPDREGQLLVDEVL Y Sbjct: 60 IRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + VQR L+N L+ +++ A+D LR N +F L SALARARADWL G+N++R Sbjct: 120 VG----NTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT+ R G + L +GRV+TP L LVVRR+ E+ F D+F VK P F A Sbjct: 176 AYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHPNGV-FWA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSAL 297 WQP++ + D +GRL+++ +A+ +V ++ P ++ + ++ + LP SLS+L Sbjct: 235 TWQPTDEQKGL-DPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSL 293 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q+ A K F Q VLD QKLYE KL TYPRSDC YLP + R+A++N + + Sbjct: 294 QVLAGKAFSYDPQTVLDTAQKLYE-KKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDE 352 Query: 358 LLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 L Q D D ++R W++KK+ AHHAIIPT + IN L++ E +Y LI++ Y+ QF Sbjct: 353 RLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQF 412 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----------------------- 451 + ++ + I ++ K +FVA R + E GW+ L Sbjct: 413 YGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAES 472 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 +++ + LP V K D +L V +QT+PP FT +TLL AM I +FV+++D Sbjct: 473 DPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNED 532 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLPEMATRPD 569 LKK L+A G+GTEATRA II+ L RGF+ G+ + T+ G L +LPE PD Sbjct: 533 LKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPD 592 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQ------------------------ 605 TA WE L +SE + F+ + L LID+ Sbjct: 593 ETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVINSDQMMPNVVRTITSQN 652 Query: 606 ----AKRTPVRQFRGIVAPGSGGS-ADKKKAAPRKRSAKKSPPADEVGSG 650 V V P ++ + P + Sbjct: 653 RKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQP 702 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats. Identities = 209/687 (30%), Positives = 331/687 (48%), Gaps = 52/687 (7%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IA VL H+ G IE G+ +VTW +GHL+ A P+ YD ++ Sbjct: 1 MKSLVLAEKPSVARDIARVLG-CHKNISGAIE-GSNYIVTWALGHLVTLADPEEYDKKFK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 W+++ LP+VP+KW+L +KQ + +K L + SEI+ A D REG+L+ +LD Sbjct: 59 AWDMSYLPMVPKKWELVVIKQTSKQYHNVKTQLFRKDVSEIIIATDAGREGELVARWILD 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++R I+ + +A++ L+ + L +A +RA ADWL GIN T Sbjct: 119 KSGCH----KPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARSRAEADWLVGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS GRVQTP L ++ R+++I +F +D++ ++ T Sbjct: 175 RALTCK-----YNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTSVTGGSVGT 229 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + + R ++ L + ++ Q VT + + +P + L+ L Sbjct: 230 MASIVTWTWQQKKSGSLRSFNKDLITGLDKKLKNQTLTVTDVHTSSKRTPSPGLYDLTEL 289 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS-VHAP 356 Q +A KRFG SA+ L+I Q LYE HK++TYPR+D RY+ + + A + Sbjct: 290 QRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKERLKACNIGPYK 349 Query: 357 DLLPQPVVDPDIRNRCW-DDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 +P+ + P ++ + DDKKV HHAIIPT + ++ NE K+Y+L+ R+++ Sbjct: 350 KYIPELLKKPLKTSKAFVDDKKVSDHHAIIPTEEYVQMEHMSNNERKIYDLVVRRFISVL 409 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG--------------SKERDEEND 460 P + + ++ + A F AK + + AGW+ + + ++ D Sbjct: 410 YPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSASQYDAYGDYEDSED 469 Query: 461 ---------------GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 LPV+ KGD L + + +T+ P FT+ATLLSAM R Sbjct: 470 FGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARFTEATLLSAMENPVR 529 Query: 506 FV--QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE 563 ++ D +KK L T GLGT ATRA IIE LF L KKG I T GK L +PE Sbjct: 530 YMSSDDNKMKKTLGETGGLGTVATRADIIEKLFHSFLLEKKGNEILLTSKGKQLLELVPE 589 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV----RQFRGIVA 619 +P++TA WE L +I++ + Q F++ + +LI K + Sbjct: 590 DLKKPELTASWEMELAKIAKGAHKEQVFIKDIESYTKELIQDIKTSDGTFRHDNLTNTKC 649 Query: 620 PGSGGSADKKKAAPRKRSAKKSPPADE 646 P G K + + Sbjct: 650 PHCGKRMLSVKGKNSRMLVCQDRECGY 676 >UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE Length = 694 Score = 581 bits (1498), Expect = e-164, Method: Composition-based stats. Identities = 249/673 (36%), Positives = 367/673 (54%), Gaps = 35/673 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 MRLFIAEKPS+A+AIA L + KGDGFIECG VTWC GH+LEQA+PD Y Sbjct: 1 MRLFIAEKPSVAKAIASELGQ-SGKGDGFIECGTD-TVTWCFGHMLEQAEPDEYTPDDVP 58 Query: 59 ------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 W + +LPI+P W L+ + +QL VI + L EA+EIV+A DPDREGQLLV Sbjct: 59 RNARGKKIWRVDELPIIPTDWMLKAKDDAKQQLAVIGKLLKEAAEIVNAADPDREGQLLV 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 DEVL++ + + +R ++ + +V+R + L+ N + +A AR RADWL Sbjct: 119 DEVLEHFRC----NKPARRFWVSAQDSVSVKRGLAALKDNGTYHGWADAARARQRADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N++RAYT+ + G +G+L+VGRVQTP L LVV RD EIE F + ++A I Sbjct: 175 GMNLSRAYTLRAQRGGSRGLLTVGRVQTPTLTLVVARDREIEAFKPIPYHTIRAAIQHSG 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 F A W ++ + D EGRL+ +A+ +V +++G+P V Y + + ++ PL F Sbjct: 235 GA-FLASW-RAKVDQAGLDAEGRLVDTAVADALVAKVTGKPGTVAEYTQEAKKQNQPLAF 292 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS + + A+ +FG SA++VL+ CQ LYETHKL +YPR+DC YLPE A V+ AI Sbjct: 293 ALSDITLLASNKFGYSAEDVLNACQTLYETHKLTSYPRTDCAYLPESQHADSPRVLKAIQ 352 Query: 353 VHAPDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQY 410 P+L DP ++++ W+D K+ AHH IIPT + S L E E +Y+LI R Y Sbjct: 353 HVNPELAGLVAGADPRLKSKTWNDSKITAHHGIIPTMHNGSKAGLIERERNIYDLIVRAY 412 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS------KERDEENDGTPL 464 L QF + + +++ FVA + + GWR + ++ +E L Sbjct: 413 LAQFYCVHEYMSTTVVVEVEDETFVATGKVVTRNGWRDVYQEVDEQDTEKDADEGGNQRL 472 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + KGD + C++ + +T+PP FT+ TLL AM I + V + + KK+LR DG+GT Sbjct: 473 PAMQKGDGVTCKQATRKDAKTKPPARFTEGTLLRAMENIHKVVPEPEHKKMLREEDGIGT 532 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 ATRA II L +RGFL KG+ I T G+++ +LPE+ P +TA +E +L I + Sbjct: 533 SATRASIISELKRRGFLETKGKQIIGTTLGRSMIDALPEVVKSPVLTALYERMLKGIEQG 592 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG---------IVAPGSGGSADKKKAAPRK 635 F+ + + +A V G G ++ Sbjct: 593 TAELAAFIAKQETFIRDQVTKANDGAVAIAGGREALPISTLYKCMACGQGLIRRPTKKAD 652 Query: 636 --RSAKKSPPADE 646 A + P + Sbjct: 653 VFWWACSNFPTCK 665 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 580 bits (1494), Expect = e-164, Method: Composition-based stats. Identities = 196/659 (29%), Positives = 328/659 (49%), Gaps = 37/659 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + IAEKPS+AR IA VL K +KG+G++E G+ +VTW +GHL+ A P++YD +Y +WN Sbjct: 5 VVIAEKPSVARDIARVL-KCDKKGNGYLE-GSKYIVTWALGHLVTLADPESYDVKYKKWN 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKR--FLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP++PE+ +L KQ N +K + +EI+ A D REG+L+ ++D ++ Sbjct: 63 LEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVR 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + ++R I+ + +A++ L+ + L SA+AR+ ADW G+N TRA Sbjct: 123 I----NKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRAL 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T + L+ GRVQTP + ++ R++EI+NF A+ ++ ++A W Sbjct: 179 TTR-----FNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQ----LKLTW 229 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + ++ + +V + A V + K++ +P + L+ LQ + Sbjct: 230 QDANGNSRS-------FNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRD 282 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K+FG SA+ L+I QKLYE HK++TYPR+D RY+ + + A V L Sbjct: 283 ANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLA 342 Query: 361 QPVVDPDIR--NRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 V+ I+ DD KV HHAIIPT + T+ E K+Y+L+ +++L P Sbjct: 343 HKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPA 402 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----SKERDEENDGTPLPVVAKGDEL 473 + + + + F+A+ + + AGW+ + + ++ LP + KGD L Sbjct: 403 FEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTL 462 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGI 531 + QT+ P F +ATLLSAM +++ +K L L++T GLGT ATRA I Sbjct: 463 TVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADI 522 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 I+ LF + K+G+ IH T G+ L +PE P +T WE L I++ + + + F Sbjct: 523 IDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVF 582 Query: 592 MQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + + +++ + K + + P G + K + Sbjct: 583 ISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGH 641 >UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105 RepID=A6GUS8_9BURK Length = 670 Score = 578 bits (1490), Expect = e-163, Method: Composition-based stats. Identities = 250/675 (37%), Positives = 367/675 (54%), Gaps = 37/675 (5%) Query: 1 MRLFIAEKPSLARAIADVLPK------PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY 54 MRLFIAEKPS+ + IA L P K IE G G VVTW GHLLE A P+ Y Sbjct: 1 MRLFIAEKPSMGKEIAKNLGGKMVNQGPAGKPPTHIEVG-GDVVTWGFGHLLEMAPPEHY 59 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+ LPI P+ ++L P+ + Q++ IK L +AS +V+AGDPDREGQ +VD Sbjct: 60 SEAFKKWSFDTLPIEPKSFELLPKSNAKAQISTIKALLKKASTVVNAGDPDREGQWVVDS 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS--EFVPLCVSALARARADWLY 172 +L++ + VQR ++ L+ +V++A+ L+ N+ +F+ SA+ R R+DW + Sbjct: 120 LLEHFG----NTKPVQRIILQALDEVSVKKALANLQPNTSPQFIGWKNSAIGRQRSDWFW 175 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 G+N+TRA+T++ G V+S+GRVQTP LGLVV RD IENF KDF+ V A IV Sbjct: 176 GMNLTRAHTLVSNVKG--QVVSIGRVQTPTLGLVVARDLAIENFKPKDFYAVSAQIVGAE 233 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 F+A W+PS+A DE GR+L +A+ V +I Q A VT++ + +SAPLP+ Sbjct: 234 PV-FSAKWKPSDAVPV--DESGRVLDANIAQTVCAKIKSQTASVTAFEAVDKKQSAPLPY 290 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 SLS+LQ+ A+K+ GL AQ VLDI Q LYE KL +YPR+DC YLPE A + + Sbjct: 291 SLSSLQLAASKKLGLGAQRVLDIAQTLYE-QKLTSYPRTDCPYLPESQHASAELIAKCLP 349 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 +L+ I++ W+D KV AHH IIPT + NL+ A VY++I YL Sbjct: 350 EKYSELV--KGASFSIKSGAWNDSKVTAHHGIIPTGQ--KANLSGELAAVYDMIVLAYLA 405 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 QF P V+++ I L++A KF A + GW+ + GS+E +E D LPV+ G Sbjct: 406 QFYPPFVYKQTTISLEVAGEKFTASGKAPISQGWKVVFGSEESEEGEDKQTLPVLQVGQS 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L+CE +V ++T PP FT+ TL+ AMT + + V D ++KK L+ T G+GTEATRA II Sbjct: 466 LICETAQVDAKKTTPPLRFTEGTLIQAMTNVHQLVDDPEIKKRLKETAGIGTEATRANII 525 Query: 533 ELLFKRGFLT-----KKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 E L R F+ K + ST G+ L LP+ +T +E L +++ + Sbjct: 526 ETLKMRKFIEIPDSGKDKGKLVSTQNGRKLIAKLPDSLKSAGITGLFEQALESVAKGETS 585 Query: 588 YQDFMQPLVGTLYQLIDQAKRT-------PVRQFRGIVAPGS-GGSADKKKAAPRKRSAK 639 FM+ + + ++ A++ + P G + Sbjct: 586 LDVFMEKQTAFVKKYVEMARKEAPATASASTPVAPSVGCPVCEKGKLRLLNGSKGAFWGC 645 Query: 640 KSPPA-DEVGSGAIA 653 + ++ Sbjct: 646 SGFRDGCKTTCPDLS 660 >UniRef50_Q5DY58 DNA topoisomerase n=1 Tax=Vibrio fischeri ES114 RepID=Q5DY58_VIBF1 Length = 664 Score = 577 bits (1488), Expect = e-163, Method: Composition-based stats. Identities = 264/654 (40%), Positives = 369/654 (56%), Gaps = 23/654 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKPSL RAIA L + G+I C NG VVTWCIGHLLE A+P+AYD +Y Sbjct: 1 MRLFIAEKPSLGRAIAASLGV-IKNEKGYITCKNGDVVTWCIGHLLELAEPEAYDKKYKS 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LPI P++W L P S +QL+V+ + +A+ +V+AGDPDREG LL++EV++Y Sbjct: 60 WSLDTLPIFPKEWILIPTDSSKEQLDVVLEQIKKATVLVNAGDPDREGDLLINEVIEYAN 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ + ++ R LINDLN +A+E A++ L NS+ +P+ +AL R+RADWL G+N+TRA Sbjct: 120 VSNDIKENALRVLINDLNSKAIETALNNLEPNSKRIPISNAALCRSRADWLLGMNITRAC 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++L + G+ VL VGRVQTP + LVV+RD EI NF DFFEV+A F A Sbjct: 180 SVLAKRKGHDNVLHVGRVQTPTIQLVVKRDIEIANFKPVDFFEVEAQFTHADI-PFKAKL 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 Q + R+ + LAE ++ I+GQ A VT KR PLPFSL LQ Sbjct: 239 Q----------NKKRIDKKDLAESMITNITGQSATVTLCETKRAKSQPPLPFSLRTLQEA 288 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 + ++G A+ LDI Q LYETHK+ +YPR+D YL ++ + L Sbjct: 289 MSSKYGYGAKETLDIAQSLYETHKITSYPRTDKNYLSTIKEDEIQLIIENLEGLNDTPLA 348 Query: 361 QPV--VDPDIRNRCWDDKKVD--AHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFC 415 Q D +R+ CW+DKK++ AH AIIPT R+ ++ L+E E VY IA +YL QF Sbjct: 349 QWASDADMSLRSPCWNDKKLEGSAHTAIIPTTRAPDLDALSEAEHNVYTAIASRYLAQFY 408 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P A I++ + +F + + GWRT+LG ++ D E LP + K + C Sbjct: 409 PTAEDDNTTIKIQSGEHEFKTTGKIEIKKGWRTVLGKEKNDTEE--QSLPSLTKDQSIDC 466 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EV+ ++T P+ +T+ TLLSAM I + V D LK L+ T GLGTEATRAGIIE Sbjct: 467 TNAEVISKKTSAPKPYTEGTLLSAMCNIGKEVTDPALKAKLKETAGLGTEATRAGIIEKA 526 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 +R +LT KG+ I ST K L +LP P +TA WE L + +C + F+ + Sbjct: 527 KEREYLTLKGKNIVSTPLAKMLVMALPNKVRDPAITAIWEQQLDVVERGECSVETFINAI 586 Query: 596 VGTLYQLIDQAKRTP----VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 T+ L+D K + + P SG + +K A + Sbjct: 587 EKTVQSLVDDLKSGKEPFTLSKSNAPACPQSGCTGFALPFEGKKSKAHQCHVCG 640 >UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales RepID=C3QFV7_9BACE Length = 725 Score = 576 bits (1485), Expect = e-162, Method: Composition-based stats. Identities = 207/624 (33%), Positives = 329/624 (52%), Gaps = 36/624 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IA+VL RK +G+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIAEVLGAHTRK-EGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKWQLQPR---PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W+L+ LP++P ++ ++ P + KQ +VI+ + A EI++ GD +EG+L+ V+ Sbjct: 59 WSLSSLPMIPPRFGIKLIGHDPGIEKQFHVIEWLMQNADEIINCGDAGQEGELIQRWVMQ 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 R V+R I+ L +A+ +L+ +EF L + L+RA DWL G+N T Sbjct: 119 KAG----ARCPVKRLWISSLTEEAIREGFSKLKDQAEFQSLYEAGLSRAMGDWLLGMNAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R YT+ + VLS+GRVQTP L L+V R EI NF K ++E+K + + F+ Sbjct: 175 RLYTLKYGQ--NKQVLSIGRVQTPTLALIVNRQLEIANFEPKQYWELKTNYR---NTTFS 229 Query: 238 AIWQPSEACEPYQDEEG------------RLLHRPLAEHVVNRISGQPAIVTSYNDKRES 285 A+ + S+ ++E+ + +R E +V RI P +VT+ K Sbjct: 230 ALIRKSDEEIAAEEEKNGGKKKIDNPGIDPIANREEGEALVERIKDLPFVVTNVGKKDGK 289 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 E AP F L++LQ+E K+F SA L + Q LYE K+ TYPR D +L ++ + Sbjct: 290 EYAPRLFDLTSLQVECNKKFAYSADETLKLIQSLYE-KKVATYPRVDTTFLSDDIYPKCP 348 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 A++ + + P + +D+ KV HHAIIPT + NLT+ E +VY+L Sbjct: 349 AILKGLRDYEVLTAPLAGTTLLKSKKVFDNSKVTDHHAIIPTGVYAQ-NLTDMERRVYDL 407 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-----EEND 460 IAR+++ F PD + ++ K +F + + E GWR + + +D EE D Sbjct: 408 IARRFIAVFYPDCKISTTTVMGEVDKIEFRVTGKQILEPGWRVVFAKEVKDPTEEKEEED 467 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP KG+ ++ E+ TQPPR +T+ATLL AM + V + +L+ L+ + Sbjct: 468 ENVLPAFVKGESG-PHIPDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDELRDALKE-N 525 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLT 579 G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ ++T WE L Sbjct: 526 GIGRPSTRAAIIETLFKRNYIRKERKNLIATPTGVELVQLIHEELLKSAELTGIWEKKLR 585 Query: 580 QISEKQCRYQDFMQPLVGTLYQLI 603 +I +K + F++ L + +++ Sbjct: 586 EIEKKTYDARQFLEELKQMVSEIV 609 >UniRef50_C5A9D2 DNA topoisomerase n=1 Tax=Burkholderia glumae BGR1 RepID=C5A9D2_BURGB Length = 722 Score = 575 bits (1483), Expect = e-162, Method: Composition-based stats. Identities = 251/695 (36%), Positives = 367/695 (52%), Gaps = 54/695 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+I EKPS+A+A+ LPKPH + +G+ E G+G V+W GH++EQ QP YD R+ + Sbjct: 1 MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDGY-VSWLAGHVMEQVQPGDYDERWGK 59 Query: 61 --WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W+L+ Q+ +I+ L + + IV+ GD DREGQLLVDEVL + Sbjct: 60 FPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLH 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V R ++ ++P +V++AI L N+ F PL + L R RADWL G+NM+R Sbjct: 120 FG----NTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE--RF 236 AYTIL + Y GVLSVGRVQ+P L LVV+RD EI+ FV KDF+ V+A P F Sbjct: 176 AYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPF 235 Query: 237 TAIWQPSE------------------------------------ACEPYQDEEGRLLHRP 260 + W P + DE+ R++++ Sbjct: 236 WSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKA 295 Query: 261 LAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKL 319 +A+ + + VT Y +K E PLPF L+ LQ ++G SA+ VLD CQ+L Sbjct: 296 VADQIAANVQAAGQGTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQEL 355 Query: 320 YETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP-QPVVDPDIRNRCWDDKKV 378 Y TYPRSDC YLP A V++AI+ AP L + IR+R W+D KV Sbjct: 356 Y-LQGHTTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDSKV 414 Query: 379 DAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAK 437 HHA+IPT ++ +TE + + Y +IA++YL Q P+ K +E+ IA +F A Sbjct: 415 TEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFAAS 474 Query: 438 ARFLAEAGWRTLLG-----SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFT 492 R + + GWR + + + ++ LPV+ + + V ++T PP +T Sbjct: 475 GRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPRYT 534 Query: 493 DATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTD 552 + +LL+AM + R V D +K L+A DG+G ATRAGIIE++ KRGF+ KG+ + +T Sbjct: 535 EGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVATV 594 Query: 553 AGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 GK L +LP T P MTA WE++L I++KQ FM + +L+ A+ + + Sbjct: 595 VGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAARVSTLP 654 Query: 613 QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 P P AKK P + Sbjct: 655 TIPPDAMPARKPYTGSSTPRPAPDGAKKCPKCKKG 689 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats. Identities = 207/640 (32%), Positives = 322/640 (50%), Gaps = 35/640 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-ARW 61 L IAEKPS+AR +A VL R GDGF++ G G +VTW +GHL+ A+P + + RW Sbjct: 5 LIIAEKPSVARELAGVLGVKGR-GDGFLQ-GPGHIVTWAVGHLVNIAEPAEQNPAWSGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKR--FLHEASEIVHAGDPDREGQLLVDEVLDYL 119 ++ LP++P ++ L PS KQ +I+ + +V+A D REG+L+ + Sbjct: 63 SMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIYLLA 122 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++R ND+ + +++A + S E L +A ARA ADWL G+N +R Sbjct: 123 G----STKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T+ +++VGRVQTPVL L+V R EIENF+ +D++ V+ E F A Sbjct: 179 FTLRA-----GSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEG-ETFKAT 232 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + ++ ++ + VV +G+ V K+ + PL F L+ LQ Sbjct: 233 WFAAPDF-----KDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQK 287 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL- 358 EA R G SAQ L I Q LYE KLITYPR+D RYL +E FA M A+ H P++ Sbjct: 288 EANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEIS 347 Query: 359 --LPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFC 415 + D + C +DKKV HHAIIPT R++ L + E +Y +I R++ F Sbjct: 348 QSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFM 407 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 DA F + + + ++ A + + GW + ++ PLP + KG + Sbjct: 408 DDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRASED----NPLPNLRKGAAVTA 463 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 + ++V +T+PP HFTDATLL+AM + + D++L+ ++ GLGT ATRA IIE L Sbjct: 464 QSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKE-RGLGTPATRAQIIETL 522 Query: 536 FKRGFLTKKGRYIHSTDAG---KALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 R ++ K G+ + +TD G + S+ P++T WE L ++ + Y FM Sbjct: 523 LARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFM 582 Query: 593 QPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 + + + + K R P K+ Sbjct: 583 HQVREMVSSGVSRVK---GSNARPPACPVVSDRKPSKEVN 619 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 573 bits (1477), Expect = e-162, Method: Composition-based stats. Identities = 215/659 (32%), Positives = 333/659 (50%), Gaps = 37/659 (5%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A IA L K D + E + V++ +GHLLE A P+ Y+ + +W+ Sbjct: 27 LIIAEKPSVANDIARALGG-FTKHDEYFES-DDFVLSSAVGHLLEIAAPEEYEVKRGKWS 84 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 A+LP++P + L P +L V+ + + + +++A D REG+L+ + + + Sbjct: 85 FANLPVIPPHFDLNPIAKSESRLKVLNKLIKRKDVDRLINACDAGREGELIFRLIAQHAK 144 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 +Q VQR + + P A+ +LR+++E PL +A R+ ADWL GIN TRA Sbjct: 145 ----AKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARCRSEADWLVGINGTRAM 200 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T G + +VGRVQTP L +VV R+E+I FV +D++EVKA V + + Sbjct: 201 TAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCASGFYEGRWY 260 Query: 241 QPSEACEPYQDEE--GRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P + + E+ RL P AE +V GQ VT K ++ +P F L++LQ Sbjct: 261 DPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTE-ESKPSTQLSPALFDLTSLQ 319 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS------ 352 EA RFG SA+N L + Q LYE HK++TYPR+D R LPE++ M + Sbjct: 320 REANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLETVKHTMEMLKESNNYL 379 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 HA +L + V P R +D+ K+ H AIIPT ++ L+E E K+Y+L+ +++L Sbjct: 380 PHAKQVLDKGWVKP--NKRIFDNSKISDHFAIIPTLQAPKA-LSEPEQKLYDLVVKRFLA 436 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P A +R ++ F + + L E GW + G + E+ + L V K ++ Sbjct: 437 VFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRETGGEDAN---LVPVQKDEK 493 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K + T+PP + +ATLLSAM G + V+D +L++ + A GLGT ATRA II Sbjct: 494 VKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAM-AAKGLGTPATRAAII 552 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRY 588 E L +L ++GR + T L L + T P++T WE L+Q+ + Sbjct: 553 EGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGEWEYKLSQMERGKLPR 612 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRG------IVAPGSGGSADKKKAAPRKRSAKKS 641 FMQ + ++ +AK G P GG K R+ + K Sbjct: 613 DAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQV---KENYRRFACTKC 668 >UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q21RE9_RHOFD Length = 1017 Score = 573 bits (1477), Expect = e-162, Method: Composition-based stats. Identities = 209/691 (30%), Positives = 331/691 (47%), Gaps = 49/691 (7%) Query: 1 MR-LFIAEKPSLARAIADVL---PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS 56 M+ L IAEKPS+A+ I L K D E + VVT +GHLLE P+ +D Sbjct: 16 MKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFES-DSYVVTSAVGHLLEIQAPEEFDV 74 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 + +W+ A LP++P + L+P +LN + + + ++++A D REG+L+ Sbjct: 75 KRGKWSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRL 134 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + Y A + V+R + + PQA+ + LRSN + +PL +A R+ ADWL GI Sbjct: 135 IEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGI 194 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N TRA T G + +VGRVQTP L +VV R+E+I FV++D++EV A A + Sbjct: 195 NGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGD 254 Query: 235 RFTAIWQPSEACE------------PYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 + P + + RL + A+ + + + GQ A VT K Sbjct: 255 YPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAIADAVRGQTASVTE-ESK 313 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 ++++PL F L++LQ EA +FG SA+ L I Q LYE HK +TYPR+D R LPE++ Sbjct: 314 PTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLP 373 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIR------NRCWDDKKVDAHHAIIPTARSSAINLT 396 +S A L + R +D+ KV H AIIPT ++ + L+ Sbjct: 374 VVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVSDHFAIIPTLQAPS-GLS 432 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 E E K+Y+L+ R+++ F P+A ++ A F + + L + GW + G + D Sbjct: 433 EAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVD 492 Query: 457 E---------ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV 507 E + G L V G+ + + E +T+PP +T+ATLL AM G + + Sbjct: 493 EVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTI 552 Query: 508 QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----E 563 +D +L+ + GLGT ATRA IIE L + ++ ++GR + T + L L + Sbjct: 553 EDDELRAAM-HEKGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVK 611 Query: 564 MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG------I 617 ++ ++T WE L + Q +FM + +++ QAK G Sbjct: 612 ELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAKEYDRDTVPGNYATLTA 671 Query: 618 VAPGSGGSADKKKAAPRKRSAKKSPPADEVG 648 P GG K+ R K+ + G Sbjct: 672 PCPNCGG--IIKENYRRYTCTGKTGAEEGCG 700 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 572 bits (1475), Expect = e-161, Method: Composition-based stats. Identities = 221/710 (31%), Positives = 352/710 (49%), Gaps = 85/710 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA-RW 61 L IAEKPS+AR +A ++ R+ GF+E G +V+W +GHL+ A+P+ D +A RW Sbjct: 5 LIIAEKPSVARELAPLVGATQRRA-GFLE-GPDHLVSWAVGHLVGIAEPEEQDPAWAGRW 62 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDYL 119 L LP++P +++L+ P Q V++R L + + +++A D REG+L+ + Sbjct: 63 TLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTGVINATDAGREGELIFRRIYLMA 122 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + A + V+R +D+ + + +++ RL ++E L +++ ARA ADWL G+N +R Sbjct: 123 ECA----KPVRRLWASDMTEEGLRKSLARLLPDAEKRNLGLASFARAEADWLVGMNYSRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA------- 232 +T+ G++SVGRVQTPVL L+ R EIE FV +DF+ V+ Sbjct: 179 FTVR-----TGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTVEGVFTPGGKGRAAQG 233 Query: 233 ------------------------------DERFTAIWQPSEACEPYQDEEGRLLHRPLA 262 + F A+W E R+ A Sbjct: 234 GVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWHRPPELR-----ETRVDSEDEA 288 Query: 263 EHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET 322 + N +G+ +V S K S+ PLPF L+ LQ EA RFGLSA++ L Q LYET Sbjct: 289 SAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKDTLAHAQALYET 348 Query: 323 HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD---LLPQPVVDPDIRNRCWDDKKVD 379 HKLITYPR+D R+L +E FA AI PD L + ++ C DD+KV Sbjct: 349 HKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKVKFPCVDDRKVT 408 Query: 380 AHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKA 438 HHAIIPT + L++ E ++Y +I R+++ FC +A F + + + + F+A+ Sbjct: 409 DHHAIIPTARKGDPARLSQPERQIYEMICRRFIAAFCAEARFATSTVTVKVGEHAFIARG 468 Query: 439 RFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLS 498 + E GW + + ++ TPLP + KG L + V RQT+ P H+TDA+LL+ Sbjct: 469 KVFKEKGWLAVEPWRAAED----TPLPPLRKGARLHTDDIRRVTRQTKAPAHYTDASLLA 524 Query: 499 AMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKA-- 556 AM + V+D++L++ ++ GLGT ATRA +IE L +RG++ + G+ + ++D G Sbjct: 525 AMETAGKLVEDEELRQAMKE-RGLGTPATRAQVIETLLQRGYVGRHGKRLIASDRGMQVA 583 Query: 557 -LFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR 615 + +L P++T WE L + Y FM + +++ + + KR R Sbjct: 584 EVIEALLPDVASPELTGTWEKALKDMEAGTATYPQFMHGIRESVWNGVHRIKRVGGRNLD 643 Query: 616 --------------GIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + P GG + PR + PPA + G A Sbjct: 644 RLLDTASERYARTPDGLCPLCGGEV---RETPRGWACTGQPPAKKRGKAA 690 >UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A8MIQ9_ALKOO Length = 716 Score = 571 bits (1473), Expect = e-161, Method: Composition-based stats. Identities = 207/656 (31%), Positives = 341/656 (51%), Gaps = 35/656 (5%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKPS+A+ IA VL K +G+IE G+ ++TW IGHL+ P+ YD RY Sbjct: 1 MKRLVIAEKPSVAKDIAKVL-NCKEKREGYIE-GSDYIITWAIGHLVILCDPEEYDIRYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 +W+ LPI+P+K +L+P P KQ ++K + + EI+ A D REG+L+ + + Sbjct: 59 KWDFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYE 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + R+ QR I+ L + + + L+ + L SA R+ +DWL GIN + Sbjct: 119 LAKC----RKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGS 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RAY+I Y +L +GRVQTP L ++V RD EI++FV KD++EVKA ++ Sbjct: 175 RAYSIQ-----YGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADF-----GNYS 224 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 IW E E ++ AE + N++ + +VT + K+ + P + L+ L Sbjct: 225 GIWIDLEKN------ESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTEL 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q ++ K+FG +AQ LDI Q LYE K ITYPR+D R+L ++ +++N I + Sbjct: 279 QRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYK 338 Query: 358 LLP---QPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQ 413 + + + R +D+KV HHAIIPT + +E E +Y+LIAR++L Sbjct: 339 EFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAV 398 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F PD + V+ +A F + + GW+ L KE + + L + KG Sbjct: 399 FYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKES--TLIHIKKGSSS 456 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + E+ ++QT+PP + +A LL +M +F++D++LK+ L+++ G+GT ATRA IIE Sbjct: 457 TLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSS-GIGTPATRASIIE 515 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 + G++ +KG+ + ST+ G+ L + + P++T WE L +I++ Q FM+ Sbjct: 516 RIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFME 575 Query: 594 PLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGS 649 + +I+ ++ + G + + PA +VG Sbjct: 576 GIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGIC---PACKVGK 628 >UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bacteroides RepID=B7AD12_9BACE Length = 729 Score = 571 bits (1472), Expect = e-161, Method: Composition-based stats. Identities = 210/680 (30%), Positives = 334/680 (49%), Gaps = 54/680 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + IAEKPS+AR IADVL K DG+IE GNG VTW GHL +P Y + Sbjct: 1 MIVCIAEKPSVARDIADVLGA-RDKRDGYIE-GNGYQVTWTFGHLCTLKEPHEYTPNWKS 58 Query: 61 WNLADLPIVPEKWQLQPR--PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 W+L LP+VP ++ ++ P+ +Q +VI+ + A I++ GD +EG+L+ V+ Sbjct: 59 WSLGSLPMVPPRFGIKLISNPTYERQFHVIENLMQHADMIINCGDAGQEGELIQRWVMQK 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 R V+R I+ L +A+ +LR S+F PL + L+RA DWL G+N TR Sbjct: 119 AG----ARCPVKRLWISSLTEEAIREGFAKLRDASDFQPLYEAGLSRAIGDWLLGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ + VLS+GRVQTP L L+V R EI+NFV K ++E+K F+A Sbjct: 175 LYTMKYGQ--NRQVLSIGRVQTPTLALIVNRQLEIQNFVPKQYWELKTVYRD---TTFSA 229 Query: 239 IWQPSEACEPYQDEE------------------GRLLHRPLAEHVVNRISGQPAIVTSYN 280 I + S+ + E+ + R ++ +I P +T+ Sbjct: 230 ILRKSDEELVLEAEKQKEGAAAKAAKPEENRGIEPITDRERGTALLEQIRNAPFTITNVT 289 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K E+ F L++LQ+E K+F SA L Q LYE K+ TYPR D +L ++ Sbjct: 290 RKNGKEAPLRLFDLTSLQVECNKKFAFSADETLKTIQSLYE-KKVTTYPRVDTTFLSDDI 348 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA 400 + ++ + + P + +D+ KV HHAIIPT + NLT+ E Sbjct: 349 YPKCPGILKGLRDYQALTAPLEGTTLLKSKKVFDNSKVTDHHAIIPTGQPPQ-NLTDMER 407 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE------ 454 +V++LIAR+++ F PD +F + ++ + +F + + E GWR + G+ Sbjct: 408 RVFDLIARRFIAVFYPDCLFATTTVIGEVEQIEFKVSGKQILEPGWRVVFGTPSAQSQEE 467 Query: 455 --RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDL 512 + LP G+ ++ E+ TQPPR +T+ATLL AM + V + +L Sbjct: 468 KDEKGGEEENVLPAFVVGESG-PHLPDLYEKWTQPPRPYTEATLLRAMETAGKLVDNDEL 526 Query: 513 KKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMT 571 + L+ +G+G +TRA IIE LFKR ++ K+ + + +T G L + E+ ++T Sbjct: 527 RDALKE-NGIGRPSTRAAIIETLFKRNYIRKEKKNLIATPTGVELIQIIHEELLKSAELT 585 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA--KRTPVRQFRGIVAPGSGGS---- 625 WE L +I ++ F++ L + +++ + AP GG Sbjct: 586 GIWEKKLREIEKRTYNAGQFLEELKQMVSEIVMSVLSDNSNRHITIQAPAPEKGGKNSAS 645 Query: 626 ----ADKKKAAPRKRSAKKS 641 +DK K P+KR+ +KS Sbjct: 646 SASASDKPKKEPKKRAPRKS 665 >UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT Length = 737 Score = 571 bits (1472), Expect = e-161, Method: Composition-based stats. Identities = 253/662 (38%), Positives = 354/662 (53%), Gaps = 30/662 (4%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 RL IAEKP LA+AI + L RK DG+ ECG+ + VTWC GH+L P+ YD RYA W Sbjct: 5 RLVIAEKPELAKAIVEGLGGGSRK-DGYYECGSDR-VTWCYGHMLALLDPEDYDERYANW 62 Query: 62 NLADLPIVPEKWQLQPRPSV--TKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 N+ADLPIV W+ +P Q I L +A +VHAGDPD EGQLLVDE+L+Y Sbjct: 63 NMADLPIVHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPDDEGQLLVDEILEYA 122 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R VQR LIND N + V R + +R N EF L +A AR+ D LYG N+TR Sbjct: 123 ----NCRLPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVGDQLYGFNITRL 178 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 YT+ R GYQG+LSVGRVQTP+LGLVVRR E ++ V + F A Sbjct: 179 YTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQFEVEGIQ-FPAR 237 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 +Q ++ DE+GRL ++ AE + +SGQPA + S K + +APLP++L LQ+ Sbjct: 238 YQVADGDPV--DEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLPYNLLKLQM 295 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL- 358 +A+++FG V DI Q L E HKLITY RSDC YL EE V+ AI+ AP L Sbjct: 296 DASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAIAQTAPMLA 355 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPD 417 +P I++R ++ KV AHHAIIPT + + LT+ E K+Y LIAR Y+ QF P Sbjct: 356 AAAQRANPTIKSRAFNSSKVSAHHAIIPTESTADLSKLTDAEQKIYLLIARAYVAQFWPK 415 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND------GTPLPVVAKGD 471 ++ + + + +F ++ GW+ L + +E+ + L + G Sbjct: 416 HLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDIEQDLRKLRDGQ 475 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLG 523 C + +++T+P +T +LLS +T +A++++D L+KIL D G+G Sbjct: 476 AGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKDKGKQGEHGGIG 535 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISE 583 T ATR II LF+RG+L +KG++I ST G+ L+ +LP+ A PDMTA W I Sbjct: 536 TPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARFPDMTALWHEQQKAIQA 595 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVR-QFRGIVAPGSGGSA--DKKKAAPRKRSAKK 640 + F+ L+ + + K + + P G KKK Sbjct: 596 GERDTLSFVNELMEYIGAEVANIKDNGLNMKIDTHPCPSCGKPLRRLKKKDKNEYFWGCT 655 Query: 641 SP 642 Sbjct: 656 GF 657 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 570 bits (1469), Expect = e-161, Method: Composition-based stats. Identities = 238/681 (34%), Positives = 365/681 (53%), Gaps = 43/681 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLF+ EKPS A+ I VL + DG+ + G+ +VTW GH+L QA PDAY +YA Sbjct: 1 MRLFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGDT-IVTWAFGHILTQAAPDAYGEQYAD 59 Query: 61 W-NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + N++ LPI+PE WQ+Q P V+KQ VIK L +A E+V A D DREG+++ E+LDY Sbjct: 60 FGNISALPILPEVWQMQVPPKVSKQFKVIKSLLAKADEVVIATDADREGEVIAREILDYC 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R+++ R + L+ Q+V++A+ + + L + LAR RADWL G+N++RA Sbjct: 120 G----YRKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLARGRADWLVGMNLSRA 175 Query: 180 YTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT G + +LS+GR+QTP L LVV+RD+EI+ FV +++ + T FT Sbjct: 176 YTAAYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTLSVDFETADKSVFTT 235 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +WQ E +++ +G + + +V ++ V + N +R+S PLP+SLSALQ Sbjct: 236 LWQVPEN---WRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTPPPLPYSLSALQ 292 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA K+ GLSA VL I Q LYE +K+ +YPR+ CRYLP+ + V AI + Sbjct: 293 KEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDVFAAIQTIDKSM 352 Query: 359 LPQ-PVVDPDIRNRCWDDK--KVDAHHAIIPTARS--SAINLTENEAKVYNLIARQYLMQ 413 L DP+ ++R W+D +HHAIIPT S L +NE VY +I +Y+ Q Sbjct: 353 LSVIEKADPERQSRVWNDNQVNKHSHHAIIPTKASNFDLSVLDKNELTVYRMIRDRYIAQ 412 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAKGD 471 F PD + V+E++ F A ++ +GW+ LLG + + ++G LP + D Sbjct: 413 FYPDFEYDSTVVEVEACSHLFKASSQSPVISGWKVLLGKDVFEGDQIDEGPALPHLKVND 472 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA---RFVQDKDLKKILRATDGLGTEATR 528 E+ ++T PP FT+A+LL M + + V+D+ ++KIL++T+GLGTEATR Sbjct: 473 EVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRKILKSTEGLGTEATR 532 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 A II+ LF+ G++ KK I++T+ G+ L +P M P TA WE L I + Sbjct: 533 ATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTMIADPITTAKWELALAGIEAGKLTL 592 Query: 589 QDFMQPLVGTLYQLIDQA-------------------KRTPVRQFRGIVAPGSGGSADKK 629 +FM + +L+ QA K+ V + V P ++ Sbjct: 593 AEFMAYQQKVITELVGQAKKDAVGKARPPKQTDSAGTKKQAVARNEDDVCPTCKEGRLRQ 652 Query: 630 KA----APRKRSAKKSPPADE 646 + ++ P + Sbjct: 653 RGFKENPDKRYWGCSRFPECK 673 >UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q01NZ0_SOLUE Length = 1333 Score = 565 bits (1455), Expect = e-159, Method: Composition-based stats. Identities = 196/628 (31%), Positives = 306/628 (48%), Gaps = 37/628 (5%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKPS+AR IA VL KG+GF+ GNG VVTW IGHL AQP D ++ W Sbjct: 11 VLAEKPSVARDIARVLGAGT-KGEGFLH-GNGYVVTWAIGHLAALAQPGEIDPQWRPWRR 68 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQL 121 LP++P +W L Q +KR L+ +V A D REG+L+ + + Sbjct: 69 NTLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVCATDAGREGELIFRYIYEAAGC 128 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + V R I+ L P A+ + D LR +++ L +A R+RADWL G+N++RAY+ Sbjct: 129 ----EKPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAARGRSRADWLVGMNLSRAYS 184 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER---FTA 238 + Y LSVGRVQTP L ++V R+ + NFV +D+ EV A + + Sbjct: 185 LA-----YSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATFHPTGAPKESVYQG 239 Query: 239 IWQPSEACEPYQDEEGRLL----HRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 W ++ + + + A + R A + S + + + + P + L Sbjct: 240 TWFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESIDAQTQRMAPPPLYDL 299 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + LQ A + FG SAQ LD Q LYE HKLI+YPR+D R+L ++ V+ AI+ Sbjct: 300 TELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVARTLPRVVAAIAEP 359 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQ 413 +LL + + R DD KV HHAIIPT ++ L +E K+Y+LI R+ L Sbjct: 360 YRELLAPGTGERPLGRRFVDDAKVTDHHAIIPTVTSAANAQLAPDERKIYDLICRRLLSA 419 Query: 414 FCPDAVFRKCVIELDIAK----GKFVAKARFLAEAGWRTL----------LGSKERDEEN 459 + D ++ + I ++ + + + GW+ L D + Sbjct: 420 WHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAPAKAKRAKSPGTADADR 479 Query: 460 DGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 LP +A G E ++++T+ P+ FT+ TLL+AM + + +K+L ++ Sbjct: 480 GEQELPPGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMETAGKTLDEKELSDAMKE 539 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 T GLGT ATRA IIE+L KR ++ + G+ + +TD G L + P MT WE+ L Sbjct: 540 T-GLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVHPEVRSPIMTGQWEAYL 598 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQA 606 +I + FM + + ++ + Sbjct: 599 HRIHRGNAQLDPFMHGIEEYVRDVVGKV 626 >UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_SPHTD Length = 769 Score = 564 bits (1454), Expect = e-159, Method: Composition-based stats. Identities = 141/683 (20%), Positives = 256/683 (37%), Gaps = 89/683 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I +L + G V +GH+ + + + Sbjct: 62 LVIVESPAKARNIGRILGR-------------GYTVKASMGHVRDLPKSKLGVETDRDFA 108 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L +K + ++ + EA EI+ A DPDREG+ + +++ Sbjct: 109 PVYL----------IPRDKSKVVKELRADVKEAREILLATDPDREGEAIAWHLVEA---T 155 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V+R + +++ P+A+ A+ R + L + AR D L G ++ Sbjct: 156 DPGDKPVRRIVFHEITPEAIREALRNPRGID--MRLVEAQQARRILDRLVGYEISPLLWR 213 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LVV R+ EI+NFV ++++ + A + Sbjct: 214 KVKRG-----LSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAELAKREAVNGRKPKPF 268 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ L +V + G V K PF+ S LQ EA+ Sbjct: 269 VASLSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQEAS 328 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ + + + I Q+LYE T LITY R+D + A V+ + Sbjct: 329 RKLNMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVIAE--RY 386 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN--------LTENEAKVYNLI 406 P+ LP + + +AH AI PT + + K+Y LI Sbjct: 387 GPEFLPDRPPVYTRKAK----GAQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLI 442 Query: 407 ARQYLMQFCPDAVFRKCVIELDIA------KGKFVAKARFLAEAGWRTLLGSKERD---E 457 ++++ +AVF +++D +F A + G+ + D + Sbjct: 443 WQRFIASQTRNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIYREGRDDDTVD 502 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E D LP + +G+ L + + TQPP FT+ATL+ A+ + Sbjct: 503 EIDREALPPLTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELG------------- 549 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHW 574 +G +T A I L R ++T + R ++ T+ G + L + + T+ Sbjct: 550 ----IGRPSTYAPTIATLQARNYVTVEQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKL 605 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKK 629 E L QI+ + + ++ G ++ +++A++ R + V G K Sbjct: 606 EDELDQIASGEQSWVPMVRAFYGPFHETVERAEKEIGRVKVADEPTDEVCEKCGRPMVIK 665 Query: 630 KAAPRKRSAKKSPPADEVGSGAI 652 + A P + Sbjct: 666 LGRYGRFLACSGFPECRNARPLL 688 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 563 bits (1451), Expect = e-159, Method: Composition-based stats. Identities = 222/667 (33%), Positives = 322/667 (48%), Gaps = 43/667 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS A AIA L ++ DG++E +++W IGHL+E P+AYD R+ RW Sbjct: 6 LIIAEKPSAAMAIAQALGG-FQRRDGYLESAE-YLLSWAIGHLVELLPPEAYDPRWKRWT 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + LPI+PE + L P Q + R +A +V+A D REG+L+ + L Sbjct: 64 METLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNACDAGREGELIFRYICAAAGL- 122 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V R ++ L P A+ A ++ + L SA RA DWL GIN TRA+T+ Sbjct: 123 ---EKPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCRAEGDWLVGINATRAFTV 179 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 +LS GRVQTP L +VVRR+ EIE+F + ++EV A TP +T W Sbjct: 180 KFGE-----LLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRTPDGREYTGKWFG 234 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + L AE VV R+ Q V + +++ +E P F L++LQ EA Sbjct: 235 PDGDR--------LSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTSLQREAN 286 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQP 362 +R+GL+A L Q LYE K ITYPR+D RYL A++ A+S + Sbjct: 287 RRYGLTAAATLKAAQALYEA-KHITYPRTDSRYLSRALVPQLPALVRALSARSDLAALAA 345 Query: 363 VVDPDI----RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 D R DD KV HHAI+PT+ LT EAK+Y+LI R++L QF PDA Sbjct: 346 GADLSRVGFGNRRVVDDAKVTDHHAILPTSEVPRS-LTGAEAKIYDLIVRRFLAQFYPDA 404 Query: 419 VFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERD-------EENDGTPLPVVAK 469 F + + + + +F ++ R L + GWR + R EE LP + Sbjct: 405 RFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEGLQLLPPLRM 464 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + E E+ T+PPR +T+ATLLSAM R + D+ L++ ++ GLGT ATRA Sbjct: 465 GEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKG-HGLGTPATRA 523 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQ 585 IIE L + G++ + R + T G+ L E+ P++T WE + I + Sbjct: 524 AIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHRIAGIQSGE 583 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSA---KKSP 642 FMQ + +L+++ + T RG S K P + P Sbjct: 584 YDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEPAAGGPPLQDRLP 643 Query: 643 -PADEVG 648 P G Sbjct: 644 TPCPRCG 650 >UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6I107_9BACT Length = 739 Score = 561 bits (1447), Expect = e-158, Method: Composition-based stats. Identities = 255/670 (38%), Positives = 364/670 (54%), Gaps = 52/670 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L IAEKPS+ARAI DV G VT GH+LE A+PDAY Sbjct: 1 MKLVIAEKPSMARAIKDV-------------VGREYEVTNAFGHILELAEPDAYLPADVP 47 Query: 59 -------ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 W DLPI+P +W+ P S QL I L +A +V+AGDPDREGQLL Sbjct: 48 VSIKTGRKIWRACDLPILPAEWRQIPIRSSKDQLIKIGELLKKADLVVNAGDPDREGQLL 107 Query: 112 VDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWL 171 +DE+LD+ + R +V+R ++ L+ ++++A LR N + PL +A+ R+RADWL Sbjct: 108 IDEILDHFR----YRGRVERVWLSALDKTSIDKAFRDLRDNRSYKPLSDAAMGRSRADWL 163 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N+TRA T+ S+GRVQTP L LVV RD IE F A+D+FEV+A I Sbjct: 164 VGMNLTRAATLS-----SGSFYSIGRVQTPTLALVVHRDLAIERFAARDYFEVRARIRHE 218 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESAPL 290 F+A+W+PS+ P DEEGRL R AE + + G+ A ++ Y K ES+SAPL Sbjct: 219 RG-TFSALWKPSDPSGPGFDEEGRLTDRRQAEAL--SLKGKGAGKISRYEKKEESKSAPL 275 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 P+SLSALQ A+ RFGLSA VL CQ LYE K+ +YPR+DCR+LP E F+ ++ A Sbjct: 276 PYSLSALQKAASGRFGLSADEVLKTCQSLYE-KKVTSYPRTDCRFLPVEQFSEAGRILQA 334 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQY 410 + V +P++ ++ W+ KV AH AI+PT A +L+E E K+Y++I Y Sbjct: 335 LPVSPDI---RPLISASRKHPAWNTAKVTAHPAIVPTGE-RAGDLSEKERKIYDMIVSSY 390 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE--ENDGTPLPVVA 468 L F PD + + +++ + + A R + GW L G +R+E E D LP Sbjct: 391 LALFLPDHRYFSAALSVEMNREIWTATGRQEIDPGWTRLFGRGDREEGGEEDLPSLPECR 450 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 G+ +L E GEV E++T+PP FTD TL+ AM+ I +FV+D + K+ L+ T G+GTEATR Sbjct: 451 PGEAVLGEGGEVREKKTRPPGRFTDGTLIEAMSNIHKFVEDPEAKQTLKETSGIGTEATR 510 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQ 585 AGI+E L R ++ +KG+ I ST+ G++L L P TA WE L+++S + Sbjct: 511 AGILETLVGREYIVRKGKQILSTEKGRSLVGFLEATLPDLVDPVTTARWEDDLSEVSAGK 570 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRT-------PVRQFRGIVAPGSGGSADKKKAAPRKRSA 638 R + F+ + + + I P GG A + R + Sbjct: 571 KRVEAFVGGIADLVREQTRTLLTKGQGGLAGDPSSPAKIACPVCGGQALVTRRESRNKKG 630 Query: 639 KKSPPADEVG 648 + Sbjct: 631 VFFWTCSQKT 640 >UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria RepID=A4JFS2_BURVG Length = 760 Score = 561 bits (1445), Expect = e-158, Method: Composition-based stats. Identities = 237/638 (37%), Positives = 361/638 (56%), Gaps = 25/638 (3%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIEC----GNGQVVTWCIGHLLEQAQPDAYD 55 M+ LFIAEKP++AR IA + K G++E G +V CIGHLL+QA+P Y Sbjct: 1 MKRLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYV 60 Query: 56 SRYA-RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 ADLPI+P++W+LQ + Q+ +++R L E E+V+AGDP REGQL++DE Sbjct: 61 KDLEFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDE 120 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L++ R+ V+R L+N L+ V+R + L+ N+ F P+ + L R RADWL G+ Sbjct: 121 LLEFCG----NRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGM 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N++RAYTILGR A Y+GVLSVGRVQ+P L LVVRRD IE FV +D++ VKA + E Sbjct: 177 NLSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGE 236 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A W+ E + DEEGR++ + AE +V GQ +T + K E LPFSL Sbjct: 237 -FWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSL 295 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + LQI A+ ++G SA+ VLD CQ LY K +YPR+D R+L A ++AI+ Sbjct: 296 ATLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQT 355 Query: 355 APDLLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLM 412 L P D I + WDD KV H+A+IPT+ ++ +LT + +Y +A++Y+ Sbjct: 356 LSMLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYIT 415 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------------GSKERDEEND 460 F PD + + +E +A+ F A R + GWR + K +E+ D Sbjct: 416 LFYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKED 475 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 P ++ G + +++T+PP +D++LL AMT + + V+D L++ L+++ Sbjct: 476 EQRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSK 535 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQ 580 G+GT ATRA IIE L ++G L ++G+ + S+ A + L +LP P ++A WE+ L Sbjct: 536 GIGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDL 595 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 ++ + FMQ L QL+++A+ T + Sbjct: 596 VAAGKAPLDLFMQKQEAWLRQLLEKAQATGLGALSDAP 633 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 560 bits (1442), Expect = e-158, Method: Composition-based stats. Identities = 250/658 (37%), Positives = 359/658 (54%), Gaps = 51/658 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY---- 58 + IAEKPS+ARAI + L N +T GH+LEQA+PDAY Sbjct: 4 VVIAEKPSMARAIREGLG----------PQANRYEITNAFGHILEQAEPDAYLPGDVPKT 53 Query: 59 ----ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 W + DLPI+P +W+ P+ QL I L A +++AGDPDREGQLL+DE Sbjct: 54 AKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDE 113 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L++ R +V R + L+ + V +A L SN ++ PL +A AR+++DW+ G+ Sbjct: 114 ILEHFH----YRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGM 169 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N+TRA T+ + S+GRVQTP L +VVRRD EIENFV +D+FEV A Sbjct: 170 NLTRAVTVK-----SGDLFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRHTQGA 224 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A W+PS P DEEGRL+ + LAE V + G V + K + +SAPLP+SL Sbjct: 225 -FLAKWEPSSTDGPGFDEEGRLIDKRLAEAVAQKAKGA-GKVARFEAKEQKQSAPLPYSL 282 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 SALQ A+ RFG+SAQ VLD CQ LYE K+ +YPR+DCRYLPEE ++ + + Sbjct: 283 SALQKVASSRFGMSAQQVLDTCQSLYE-KKITSYPRTDCRYLPEEQLVDAPRILGKLPIP 341 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 +P+++P ++ W++ K+ AH+AI+PT A L++ EAK+Y+LI R Y+ F Sbjct: 342 DGI---RPLLNPRQKHVAWNNAKITAHNAIVPTGE-PARGLSDAEAKLYDLIWRSYVALF 397 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----SKERDEENDGTPLPVVAKG 470 PD +R + + + A R + GW+ L G + D + PLPV+ G Sbjct: 398 LPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTG 457 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + + G+V RQT+PP FTD +L+ AM+ I +FV D K L+ T GLGTEATRA Sbjct: 458 DPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRAS 517 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM----ATRPDMTAHWESVLTQISEKQC 586 ++E L +R +L KKG+ + ST G+AL L + P TA WE VL ++E + Sbjct: 518 VLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKV 577 Query: 587 RYQDFMQPLVGTLYQLIDQAK---------RTPVRQFRGIVAPGSGGSADKKKAAPRK 635 Q F + + + I+ K + + R P GG A ++ +K Sbjct: 578 PMQKFTAAVTQEVAKAIEVLKSGSAMAGGGSSSQQPLRAQPCPICGGDAVVRRLQSKK 635 >UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q099E1_STIAU Length = 1504 Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats. Identities = 193/652 (29%), Positives = 311/652 (47%), Gaps = 56/652 (8%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKP++AR IA L ++G+G+ GNG VVTW IGHL+ AQP + RW+ Sbjct: 33 VVAEKPAVARDIARALGA-TQRGEGWFR-GNGYVVTWAIGHLVGLAQPHEMHPAWKRWHR 90 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRF--LHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 LP++P W L + Q V++ E S +V A D REG+L+ + + Sbjct: 91 EQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGC 150 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 R+ V+R ++ L A+ L+ + L +A R+RADWL G+N++R YT Sbjct: 151 ----RKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYT 206 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-----PADERF 236 + LSVGRVQTP L ++V R+ I +FV +D+ EV A PA ++ Sbjct: 207 LACGE-----TLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQY 261 Query: 237 TAIWQPSEACE-------PYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 W + ++ A V+ R+ A++ S + + + P Sbjct: 262 RGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPP 321 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ A + +G SAQ L++ Q LYE HKL++YPR+ R+L V+ Sbjct: 322 LLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVR 381 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIAR 408 AI LL + + R DD KV HHAIIPTA S L +E ++Y L+ R Sbjct: 382 AIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCR 441 Query: 409 QYLMQFCPDAVFRKCVIELDIAK----------GKFVAKARFLAEAGWRTL--------- 449 + L + + V+ + ++ +F + + GW+ L Sbjct: 442 RLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPP 501 Query: 450 ---------LGSKERDEENDGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSA 499 + ++ E++ LP +A+G + E E V+++T+PP TDA+LL+A Sbjct: 502 KGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTA 561 Query: 500 MTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFH 559 M R + +K+L ++ T GLGT ATRA IIE+L +R +L ++G+ + T+ G L Sbjct: 562 METAGRTLDEKELADAMKET-GLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQ 620 Query: 560 SLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV 611 + P MT WE+ L +I Q Q F++ + + +++ + P+ Sbjct: 621 VVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPM 672 >UniRef50_Q1DEW9 DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family n=6 Tax=Bacteria RepID=Q1DEW9_MYXXD Length = 1560 Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats. Identities = 208/657 (31%), Positives = 328/657 (49%), Gaps = 51/657 (7%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 +AEKPS+AR IA VL + +G+G++ GNG VVTW IGHL+ AQP + + +W+ Sbjct: 1 MLAEKPSVARDIARVLGA-NERGEGWLR-GNGYVVTWAIGHLVGLAQPHEIRADWKKWSR 58 Query: 64 ADLPIVPEKWQLQPRPSVTKQLNVIKRF--LHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 A LP++P W L Q V+K+ E S +V A D REG+L+ + D + Sbjct: 59 ALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKC 118 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 R+ VQR ++ L +A++ RL E+ L +A+ R+RADWL G+N++R YT Sbjct: 119 ----RKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYT 174 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER-----F 236 + + G+ +LSVGRVQTP L +VV R+ I +FV +D+ E+ A A + Sbjct: 175 LA--HGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALY 232 Query: 237 TAIWQPS---------EACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 W S E ++ + A+ +++R+ AI+ S + + + Sbjct: 233 KGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMA 292 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL + L+ LQ A + G SAQ L++ Q LYE HKL++YPR+ R+L V Sbjct: 293 PPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEV 352 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLI 406 +NAI + L + R DD KV HHAIIPT + L+ +E +VY+L+ Sbjct: 353 VNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLV 412 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAK-------GKFVAKARFLAEAGWRTLL--------- 450 R+ L + D V+R + + +F + + + GW+ L Sbjct: 413 CRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPR 472 Query: 451 --------GSKERDEENDGTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMT 501 ER+ E++ LP +A+ E E V+++T+PP FTDATLL+AM Sbjct: 473 LKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAME 532 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 R + +K+L +R T GLGT ATRA IIE+L R +L ++G+ + +T+ G L + Sbjct: 533 SAGRALDEKELADAMRET-GLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVV 591 Query: 562 PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 P MT WE+ L +I + + +F++ + + +++ P R R V Sbjct: 592 HPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEV 648 >UniRef50_Q4L0S6 TraE-like protein n=3 Tax=Gammaproteobacteria RepID=Q4L0S6_HAEIN Length = 750 Score = 558 bits (1438), Expect = e-157, Method: Composition-based stats. Identities = 217/668 (32%), Positives = 344/668 (51%), Gaps = 23/668 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKP L IA+ + RK DG+IEC G VTW IGH+LE +P+ + Y Sbjct: 1 MRLVIAEKPQLGAVIAEAIGIVGRK-DGYIECKGGYNVTWAIGHVLELKEPNEINPAYKN 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN DLP+ +L+P+ + KQ +I+ L +A +V+AGDPD EGQLL+ E+L+Y Sbjct: 60 WNAKDLPLKLRPMELKPKANTEKQFRIIESLLKKADTVVNAGDPDDEGQLLIREILEYTG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R L+NDLN +A +A+ L+ +SEF + ALAR+ AD+++G+N++RAY Sbjct: 120 F----KGTVERLLLNDLNVEAARKAMKNLKPDSEFDGMYYKALARSHADYIFGMNLSRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA---DERFT 237 T+ R G V S+GRVQTPVLGL+VRR +N ++ + + + R Sbjct: 176 TLSAREKGLDSVYSIGRVQTPVLGLIVRRYLANKNHKESFYYNLSGNFSFQDKTLNARLV 235 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 S + +E R++ +A+++ + + ++ APLPF+L L Sbjct: 236 ITDNISTDPNDEESKEKRIIDENIAKNIQKDCEKHTVNIIQCGIEAKTTPAPLPFALLDL 295 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q + ++G SA L I Q L E H+ ITY RSDCRYL E F ++ +S P+ Sbjct: 296 QAKINDKYGFSADETLAITQSLREKHQAITYNRSDCRYLSTEQFEAAPKTLDFLSGLFPE 355 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPT---ARSSAINLTENEAKVYNLIARQYLMQF 414 LP D ++R ++DKKV AH IIP S+ L++ E KVY I QYL+QF Sbjct: 356 -LPFNSADRSRKSRAFNDKKVTAHTGIIPVVSDKFSNISALSDKEQKVYRAIVEQYLVQF 414 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT--PLPVVAKGDE 472 P+ + + + + +F A + + GW L+ DE ++ + + Sbjct: 415 LPEKQYDLASVTIQCSDYQFRTSATKITDHGWSKLVPDDAEDENDNAKFDLIASLQADAS 474 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGT 524 +CE E+ + +T+P +T+ATLL + +AR+++D +KK+L D G+GT Sbjct: 475 GMCESVEIKKEKTKPQPIYTEATLLKDLQRVARYIEDPRIKKLLIEKDKGREGENGGIGT 534 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 ATR+ +I+ L +GF +G+ + T G +LP + T PD TA W I + Sbjct: 535 PATRSAVIKNLHDKGFFEYQGKKLIPTQKGIDFIEALPRIVTVPDTTALWFEQQLAIEKG 594 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + +F+ + + + I+ AK + + +G G KK + A + P Sbjct: 595 ELSVDEFLDEIEKFVGEQIEAAKNVKL-EVKGEPCSCGQGVLVLKKFKDSEFFACTAYPT 653 Query: 645 DEVGSGAI 652 ++ A+ Sbjct: 654 CKITKPAL 661 >UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0B0_THERP Length = 744 Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats. Identities = 132/681 (19%), Positives = 256/681 (37%), Gaps = 88/681 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR IA L G V +GH+ + + + Sbjct: 37 LVIVESPAKARTIARFLG-------------PGYTVKASMGHVRDLPKSKLGVDVAQNF- 82 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + ++ + A E++ A DPDREG+ + +++ + Sbjct: 83 ---------QPTYTVLKEKLPVVKELQESVQRARELILATDPDREGEAIAWHLIEATRAH 133 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V+R + +++ +A+ A+ R + L + AR D L G ++ Sbjct: 134 D---KPVRRIVFHEITEEAIREALAHPRGID--MRLVNAQQARRVLDRLVGYEISPLLWR 188 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 ++ LS GRVQ+ L LVV R+ EI+ FV ++++ ++ +V + + Sbjct: 189 KVKSG-----LSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPF- 242 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + A + E+ L + A V + V S ++++ PF S LQ EA Sbjct: 243 AAALVRVRGEKPDLPNEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAG 302 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ + + Q+LYE + LITY R+D + V+ A Sbjct: 303 RKLRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVIAA--RW 360 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP+ + + +AH AI PT + LT + ++Y LI + Sbjct: 361 GADFLPERPPVYAKKAK----GAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWER 416 Query: 410 YLMQFCPDAVFRKCVIELDIA-------KGKFVAKARFLAEAGWRTLL---GSKERDEEN 459 ++ A++ +E+ A + G+ + ++ +E Sbjct: 417 FIASQMAPAIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDEL 476 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 D PLP +A G+ L + TQPP +++ATL+ + + Sbjct: 477 DQRPLPPLATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELG--------------- 521 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 +G +T A IE L +R ++ + R + T+ G + L + T+ E Sbjct: 522 --IGRPSTYAPTIETLKQRRYVVVEDRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEE 579 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKA 631 L +I+ + + ++ ++ +++A++T R Q G V G K++ Sbjct: 580 ELDEIAAGERDWVPVVREFYEPFHRQVEEAEQTMERVRLADQPSGEVCELCGRPMVIKES 639 Query: 632 APRKRSAKKSPPADEVGSGAI 652 + + P + + Sbjct: 640 RFGRFLSCSGFPECKNKRPLL 660 >UniRef50_Q6AJY0 DNA topoisomerase n=1 Tax=Desulfotalea psychrophila RepID=Q6AJY0_DESPS Length = 820 Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats. Identities = 192/628 (30%), Positives = 313/628 (49%), Gaps = 18/628 (2%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L IAEKPS+A +A VLP K E + +V++ +GHL+ P+ D Y +W Sbjct: 5 ILIIAEKPSVAGDLAKVLPGKFTKQKTHYES-DSHIVSYAVGHLVSLCYPEEIDPIYQKW 63 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 LA+LPI+PE + L+ + QLN +K+ + EI++A D REG+L+ +L Y+ Sbjct: 64 GLANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYV 123 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 ++ ++R + + +++++ + LR N L +AL R+ +DWL G+N TRA Sbjct: 124 WNTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRA 183 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T G + GRVQTP L L+V+R+ F D+ ++A+ ++ Sbjct: 184 LTGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFETG-SYSGK 242 Query: 240 WQPSEACEPYQD---EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 W + ++ + R+ + A ++ + +PA T N K +SAP F L+A Sbjct: 243 WIDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATE-NSKESRQSAPQLFDLTA 301 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA RFG SA+N L I Q LYE HK +TYPR+D R+LPE++ + + Sbjct: 302 LQREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEF 361 Query: 357 DLLPQPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQ 413 + + + + R +++KK+ HHAIIPT NL+E E K+Y ++ +++L Sbjct: 362 AAIAKTALKEGYIKAQTRIFNNKKISDHHAIIPTNTLPQ-NLSEPELKIYTMVVQRFLAI 420 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F P AVF + F+ + + L EAGW+ + L + G + Sbjct: 421 FFPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYA-GADGSTGKDKILAPIPTGSPV 479 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 C K E T PP + +ATLLSAM +F+++++L ++ GLGT ATRA IIE Sbjct: 480 TCNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKE-RGLGTPATRATIIE 538 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQ 589 L K ++ ++ + + T LF + + P+MT WE L QI + + Sbjct: 539 KLIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRD 598 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGI 617 DFMQ + Q++D+ + + R + Sbjct: 599 DFMQEIRQLTQQIVDRVRDFNTDEERSL 626 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats. Identities = 176/646 (27%), Positives = 303/646 (46%), Gaps = 20/646 (3%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A + VL K + + +V+ IGHL+ A P D RY W+ Sbjct: 35 LIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDIDERYKAWD 94 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 + LP++PEK+ L P+ L+ + + + I++A D REG+L+ ++DY+ Sbjct: 95 MKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELIFYYIVDYIL 154 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 K + +R + + P A++ A + LR+ + V L +AL R+ ADWL G+N +R Sbjct: 155 KGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWLVGMNGSRGL 214 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T + G + GRVQTP L ++V+R+EE F+ + F+ ++A + W Sbjct: 215 TAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWTIEASFDNAG-AGYQGKW 273 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + +D ++ A+ ++ + G+ + + + L+ LQ E Sbjct: 274 FTVDKEN-GKDRVKQIFDEARAQEILAKCKGKTGSIEE-TTAPSQQKCGQLYDLTTLQRE 331 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A RFG SA+ L I Q LYE +K TYPR+D R LPE++ A A + I Sbjct: 332 ANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVKATLGKIEGPLAKFAQ 391 Query: 361 QPVVDPDIRN--RCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 + + ++ + +D+ K+ H AIIPT L+E E K+Y +I ++++ F P A Sbjct: 392 EALDKNYVKRTPKVFDNSKISDHFAIIPTGVVPK-GLSEAEEKIYTMICQRFIAVFFPPA 450 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + + F+ + + L + G++ + G + +E N +P + G+ Sbjct: 451 QYLNTTRITTVENETFITEGKILVDPGFKAIYGKESDEESN----IPKLN-GNTAKTLAI 505 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 E E T+PP H+T++TLLS M + V+D +L+ ++ GLGT ATRA IIE L Sbjct: 506 ESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKE-RGLGTPATRAAIIEKLVSD 564 Query: 539 GFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 ++ + G+ + T L L E T P++T WE + IS+ + + FM Sbjct: 565 KYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEYKMDLISKGKESREAFMNG 624 Query: 595 LVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSADKKKAAPRKRSA 638 ++ ++ K + +P +G + + Sbjct: 625 IIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKVFETVSRYTTEDG 670 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 556 bits (1434), Expect = e-157, Method: Composition-based stats. Identities = 141/672 (20%), Positives = 254/672 (37%), Gaps = 82/672 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ L K V +GH+ + + + Sbjct: 5 LVIVESPAKAKTISKFLGKK-------------FTVKASMGHVRDLPKSQFGVDVKNGFK 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + ++ + +A +++ A DPDREG+ + + + L++ Sbjct: 52 P----------KYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIAWHLQNLLEID 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R N++ QA+++A+ R + AR D L G N++ Sbjct: 102 ENESC---RIEFNEITKQAIQKALQHPRPIDR--NRVNAQQARRILDRLVGYNLSPLLWR 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + L+ R+EEI++FV ++++ + A V + F Sbjct: 157 KIKKG-----LSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 ++DE+ + + + V+ + G V K +S PLPF S LQ EA Sbjct: 212 ------FRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAY 265 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ +A+ + + Q+LYE T LITY R+D + + + Sbjct: 266 RKLNFTARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYI--VERF 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + P + K DAH AI PT+ LT ++ K+Y LI + Sbjct: 324 GARYAGRE--TPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSR 381 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVA 468 +L AVF I++ + F A + G+ + D E+ + LP + Sbjct: 382 FLASQMKPAVFDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELK 441 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+E+ + TQPP +TDA+L+ A+ G+G +T Sbjct: 442 EGEEIEARSLTPRQHFTQPPPRYTDASLVRALEE-----------------KGIGRPSTY 484 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A I+E + KRG++ ++ + T+ G + L + D TA E L I E + Sbjct: 485 APIVETILKRGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGE 544 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV-----RQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 + ++ G +++A+ + G S K K A Sbjct: 545 LDWIKVLESFYGPFKNTLEKAENEIGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACP 604 Query: 641 SPPADEVGSGAI 652 P + Sbjct: 605 GFPECRSTKPLL 616 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 556 bits (1433), Expect = e-157, Method: Composition-based stats. Identities = 201/617 (32%), Positives = 327/617 (52%), Gaps = 20/617 (3%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA+ L KG I + +++ +GH++E P DSR+ +W+ Sbjct: 5 LVIAEKPSVAQDIAEALGG-FPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHRQWS 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L++LPI+P + L+P +LN++ LH + I++A D REG+L+ ++ + Q Sbjct: 64 LSNLPILPSSFSLKPIQKHKDRLNLLLSLLHREDVDLIINACDAGREGELVFRYLIRFAQ 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + +QR + + A+ A LR E L +A++R+ +DWL GIN TRA Sbjct: 124 V----NKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAVSRSESDWLIGINGTRAL 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L N+ + SVGRVQTP L LVV RD+EI +F K ++E+ A + E + A W Sbjct: 180 TALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWEILATFRSKQGE-YKAKW 238 Query: 241 QPSEACEPYQDEEG-RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + +D R+ + + ++ + + IVT K +S PL + L++LQ Sbjct: 239 FSRNSQHEGEDNHPERIENEDQCQSIIEKCLNKEGIVTE-EKKVSQQSPPLLYDLTSLQR 297 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA RFG SAQ L I Q LYE HKLITYPR+D ++LPE++ V+ +S + Sbjct: 298 EANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYVPRVKEVLKNLSHGPFETF 357 Query: 360 PQPVVDPD---IRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCP 416 + ++ + N+ ++++KV H AIIPT L NE K+Y LI R++L F P Sbjct: 358 AREILSQNWVQPANKIFNNQKVSDHFAIIPTTHKPTT-LNANEEKIYQLIVRRFLATFYP 416 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 A + + + F + + L AGW + + + L + +G+++L Sbjct: 417 PAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSNPAQNTEEDVLCPIEQGEKVLNL 476 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 E + ++T+PP HFT+ATLLSAM + V+D+ L++ + A GLGT ATRAGIIE L Sbjct: 477 AMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETLREAM-AKKGLGTPATRAGIIEGLI 535 Query: 537 KRGFLTK-KGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQISEKQCRYQDF 591 + G++ + G+ + +T AL L + ++T WE L + +++ + F Sbjct: 536 EDGYIRRQDGKALVATPKAFALIELLSAAQIQTLRSAELTGEWEFKLQMMEKEKYSQEKF 595 Query: 592 MQPLVGTLYQLIDQAKR 608 M+ + ++D+AK Sbjct: 596 MEEIYQLTASIVDKAKA 612 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 555 bits (1431), Expect = e-156, Method: Composition-based stats. Identities = 219/662 (33%), Positives = 329/662 (49%), Gaps = 34/662 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFI----ECGNGQVVTWCIGHLLEQAQPDAYDS 56 MRL IAEKPS A+ +A P RK + I G +V W +GHL E +P Y Sbjct: 1 MRLIIAEKPSQAQKLAAPYPSKKRKEEIEISPCPRFPEGAIVVWAVGHLCELQEPSHYRP 60 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDE 114 + W LPIVPE++ + +K IK++LH+ S +++ A D +REG+ +V Sbjct: 61 EWKSWKYEALPIVPERFDYRISKGKSKPFYAIKKWLHDRSITDVIIASDAEREGEAIVRL 120 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 +L ++ + R I+ L QAV+R +L + +P A++RA ADWL G+ Sbjct: 121 ILRLAG----NKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYHEAMSRACADWLVGM 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RAYT L + G + V S+GRVQTP L L+V R+ EI+ FV + +FEV+A + Sbjct: 177 NASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEPYFEVEATLA-KGRG 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F A + + +L R A+ VV R SG AIV + + + + E P FSL Sbjct: 236 TFKAKYT--------FGKTTKLKTREEADAVVKRASG-TAIVKTIDKEEKIEQPPFWFSL 286 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI--S 352 S LQ EA KRFG A+ LDI QKLY T I+YPR+D ++ + + S Sbjct: 287 SGLQAEAGKRFGFGAKKTLDIAQKLY-TKGWISYPRTDSGFVTPDEATLFPQTKARLLKS 345 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYL 411 L DP R + KKV H+AIIPT L +EAK+Y+LI R++L Sbjct: 346 DAYAGLRDLLTEDPSKNRRYVNAKKVSDHYAIIPTEACGDVTRLGGDEAKLYDLINRRFL 405 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A+ K ++L + AK + G+R ++ K +D E LP + G+ Sbjct: 406 AAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVE-----LPALTVGE 460 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 E +K EV+ +QT+PP+ +T+ L+ AM + + D++L I++ +GLGTEATRA I Sbjct: 461 EFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLGTEATRANI 520 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCRYQD 590 I+ L KRG++ + + + TD G+ L L + P MTA WE L +I + + Sbjct: 521 IDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSILASPVMTAKWEKRLHEIGQASASAAE 580 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 F++ L+++AK + G A + R G G Sbjct: 581 FIEQAKKMSVHLVEEAK----SRVEAANPEGYTIEAKRYGKKGTTRPKASFGICPNCGKG 636 Query: 651 AI 652 + Sbjct: 637 LV 638 >UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=B5EJ79_ACIF5 Length = 851 Score = 555 bits (1430), Expect = e-156, Method: Composition-based stats. Identities = 138/675 (20%), Positives = 254/675 (37%), Gaps = 84/675 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + V GH+ + + + Sbjct: 5 LVIVESPAKAKTIQKYLG-------------DDFQVLASYGHVRDLQPKEGAVDTEHDFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + P + ++ I + L A ++ A DPDREG+ + +++ L+ Sbjct: 52 M----------RYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRER 101 Query: 123 -PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + QR + +++ +AV+ AI R + + L + AR D+L G N++ Sbjct: 102 QLLGDKPTQRVVFHEITKKAVQEAIAHPREIA--MDLVNAQQARRALDYLVGFNLSPLLW 159 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L L+ R+ EIE FV+++++ + + + FT Sbjct: 160 RKVRPG-----LSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSA-FTGRLT 213 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVV----NRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + E+ + A+ + + + Q V K PF+ S L Sbjct: 214 HWQNKKL---EQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTL 270 Query: 298 QIEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q EA+++ G +A + + Q+LY ET LI+Y R+D L EE A ++ Sbjct: 271 QQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFID- 329 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 + + +P+ R + +AH AI PT + L + ++Y+L Sbjct: 330 -GYYGSEFVPE----TPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDL 384 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKG-KFVAKARFLAEAGWRTLL--GSKERDEENDGT 462 + ++ + A +++D A + G+ + G + DE+ Sbjct: 385 VWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNR 444 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + GDE L + + T+PP ++DATL+ + G+ Sbjct: 445 ILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLE-----------------AHGI 487 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A II+ L R ++ + R H TD G+ + L TA E L Sbjct: 488 GRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELD 547 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQ----AKRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 +S + ++Q + L+D+ ++ + P G + + Sbjct: 548 AVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGR 607 Query: 636 RSAKKSPPADEVGSG 650 A P Sbjct: 608 FVACSGYPECNYTRP 622 >UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6_OPITP Length = 939 Score = 554 bits (1427), Expect = e-156, Method: Composition-based stats. Identities = 198/670 (29%), Positives = 314/670 (46%), Gaps = 40/670 (5%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR-Y 58 M+ L IAEKPS+A +A L K ++GD + + VV++ +GHL+E P+ D + Y Sbjct: 1 MKSLVIAEKPSVAADLARALGKIPKQGDHY--ENDQYVVSYAVGHLVELEMPEDIDKKKY 58 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVL 116 W L LPI+PEK+ L+P + N +K+ L + +++A D REG+L+ + Sbjct: 59 GFWRLETLPIIPEKFGLKPIEESKDRFNALKKLLARKDIELVINACDAGREGELIFAYLY 118 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + + V+R + + + + A LR + L +A R+ +DWL GIN Sbjct: 119 QLTKC----KLPVKRAWMQTMTAEGIREAFAHLRDGEQMAGLAAAARCRSESDWLIGING 174 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA T + V SVGRVQTP L +V R+ EI NF + ++++ A R+ Sbjct: 175 TRALTKRMFGSRAGNVASVGRVQTPTLAIVYSRELEIRNFKPRAYWQITATFEVTNG-RY 233 Query: 237 TAIWQPSEACEPYQDEE---GRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +Q + + DE R+ + +AE +V GQP K ++ AP + Sbjct: 234 EGTYQRPDFKKSDADEHDRVDRIWEQAVAEAIVAACQGQPPAAVREEKKASTQIAPRLYD 293 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L+ LQ EA RFGLSA+ L I Q LYE HK+ITYPR+D R LPE++ + + Sbjct: 294 LTTLQREANNRFGLSARRTLQIAQALYERHKMITYPRTDSRALPEDYIPTVRETLKNLHG 353 Query: 354 HAPDLLPQPVVDP--DIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 Q + R +++ ++ H AIIPTA + +L E EAKV+++IAR+++ Sbjct: 354 PLAPHAQQVLDQGWVRPNRRIFNNAQISDHFAIIPTAHEAK-HLDEMEAKVFDMIARRFV 412 Query: 412 MQFCPDAVFRKCV-IELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE-NDGTPLPVVAK 469 F P A F I + +F + + L GW + G +++ LP ++ Sbjct: 413 AAFFPPAEFDITTRISTVAGRHEFKTEGKVLTVPGWLAVYGRTTVEDDAPGSKSLPALSD 472 Query: 470 GDELLCE------------KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 D + T+PP +T+ATLLSAM G + V D+DL + ++ Sbjct: 473 ADRATVARGDDAPAQAKTLDPVLHAETTKPPPRYTEATLLSAMEGAGKLVDDEDLAEAMK 532 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAH 573 GLGT ATRA I+ L + ++ + R + T + L L + T P MT Sbjct: 533 E-RGLGTPATRADTIDGLINQKYMERGQRELIPTAKAEQLLQFLSAVHTDALTSPAMTGE 591 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ----FRGIVAPGSGGSADKK 629 WE L QI + ++FMQ +V ++D+ K I +P + Sbjct: 592 WEFKLRQIEHGKFSREEFMQEVVEQTKGIVDRVKNFEEDDSAARETDIPSPTDNKPLRET 651 Query: 630 KAAPRKRSAK 639 + + Sbjct: 652 LRGYKSHDGE 661 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 553 bits (1425), Expect = e-156, Method: Composition-based stats. Identities = 176/657 (26%), Positives = 304/657 (46%), Gaps = 43/657 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+AR IAD L ++K +G+IE +VTW +GHL+ A P+ YD+ Y Sbjct: 2 MKSLILAEKPSVARDIADALHIKNKK-NGYIE-NEKYIVTWALGHLVTNAAPEQYDASYK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 W L DLPI+P+ + +KQ ++K + + +I+ A D REG+L+ +LD Sbjct: 60 EWKLEDLPIIPKYMKTIVIGKTSKQFKIVKSLILDKKVKDIIIATDAGREGELVARLILD 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ +QR I+ + +A++ L+ + L +ALAR+ ADW+ GIN T Sbjct: 120 KVG----NKKPIQRLWISSVTKKAIQEGFKHLKDGRAYNSLYHAALARSEADWIVGINAT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS+GRVQTP + LV R ++I +F + ++ + + Sbjct: 176 RALTTK-----YDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYYTLSIKV--------- 221 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + E + + ++ E + ++ Q V K + ++L+ + Sbjct: 222 ------DGYEFTFNTQKHFKNKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQLYNLTDI 275 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q +A +RF + + L+ Q LYE HK++TYPR+D YL + + + A+ Sbjct: 276 QQDAYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQALLATNYK 335 Query: 358 LLPQPVV--DPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 + ++ + ++D KV HHAIIPT ++ L++ E K+Y LI ++L Sbjct: 336 SHVRELIGQSFSPKMSIFNDSKVSDHHAIIPTEVRPSLEQLSQREFKIYMLIVERFLESL 395 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 + + ++ F K + G++ L +++ + G + Sbjct: 396 MKPYEYEGVTVNFEVGDLMFSLKENIPKQLGFKAL-----KEDTLQPSKSHQFVIGQQFK 450 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFV--QDKDLKKILRATDGLGTEATRAGII 532 +K ++ E +T+PP +F + +LL AM ++ +K + L+ T G+GT ATRA II Sbjct: 451 VQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTGGIGTVATRADII 510 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 + LF L + I T GK + P T P +TA WE LTQI + + + FM Sbjct: 511 DKLFNMNALEVRDGKIKVTSKGKQILELAPSELTSPLLTAQWEEKLTQIEKGRYNSKKFM 570 Query: 593 QPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 + ++ + K + + P G K K + + P Sbjct: 571 DEMKHFTKDIVQKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCK 627 >UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP3_BACSK Length = 729 Score = 552 bits (1423), Expect = e-155, Method: Composition-based stats. Identities = 203/663 (30%), Positives = 321/663 (48%), Gaps = 35/663 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 + +AEKPS+AR IA VL ++KG+G++E GNG ++TW +GHL+ A P+ Y +Y W Sbjct: 4 KAVLAEKPSVARDIARVLG-CNQKGNGYLE-GNGYIITWALGHLVTHADPEHYGKQYKTW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYL 119 L +LP++P++ +L KQ + +K L+ E+V A D REG+L+ +L+ Sbjct: 62 KLEELPMLPKRLELVVIKQTAKQFHAVKHVLNRQDVGEVVIATDAGREGELVARWILEKA 121 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ V+R I+ + +A++ +L+ + L +A ARA ADW GIN TRA Sbjct: 122 HV----KKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAAAARAEADWYVGINGTRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T + LS GRVQTP L ++ R+E I FV K + + T F Sbjct: 178 LTTK-----HNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISV--ETKDGVTFR-- 228 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + +E R+ A+ + ++ ++ S N K + P + L+ LQ Sbjct: 229 ------WADRRSKEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYDLTELQR 282 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA KRFG SA+ L Q+LYE HK +TYPR+D RYL + ++A+ V + Sbjct: 283 EANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDVQPFRKM 342 Query: 360 PQPVVDP---DIRNRCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFC 415 + + + +D KV HHA+IPT SA +++ EAK+Y+LI R++L F Sbjct: 343 VANAKKQGLANAKRQMVNDAKVSDHHALIPTEQPQSASAMSDKEAKLYHLIVRRFLANFF 402 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P + +E AK L AGWR ++E LP ++KGD+ Sbjct: 403 PPSESELTSVEATANGELLRAKGERLVSAGWRG--QETGEEDEALARLLPAMSKGDKKAV 460 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGIIE 533 + + + +T PP F + TLL+AM A+ ++ D+ +KK L G+GT ATRA IIE Sbjct: 461 KWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVATRADIIE 520 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 LF ++ KKG+ ++ T GK L +P P +TA WE L +I + + + Q F+ Sbjct: 521 KLFSSFYIEKKGKDLYITSKGKQLLELVPAELKSPALTAEWEQRLEKIVQGKEQKQMFIA 580 Query: 594 PLVGTLYQLIDQAKRT----PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGS 649 + ++ Q K G P G + K + + Sbjct: 581 EMKEYAKAVVAQVKADTATFRHDNKTGEKCPECGKFLLEVNGKKGKMRVCQDRECGYRKN 640 Query: 650 GAI 652 A+ Sbjct: 641 IAM 643 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 552 bits (1423), Expect = e-155, Method: Composition-based stats. Identities = 184/663 (27%), Positives = 294/663 (44%), Gaps = 48/663 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A+ IA L + D ++E +++ GHL+E S + Sbjct: 5 LIIAEKPSVAKDIALALGG-FGRVDNWLES-PDAIISSAQGHLVEVFSTLMDTSGK---D 59 Query: 63 LADLPIVPEKWQLQPRPSVTK--QLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 L LP++P + L+ + +KR + + +V+A D REG+L+ + Sbjct: 60 LQSLPVIPPSFDLRVIDGANRPQLFAQLKRLMSRQDVDAVVNACDAGREGELIFRLIYKL 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++R + P+A+ + ++ ++F L +A R D+L GIN +R Sbjct: 120 AGCT----KPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSDAAFCRTEGDYLVGINGSR 175 Query: 179 AYTILG-RNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 T L R SVGRVQTP LV R+ I F AKD++EV H A Sbjct: 176 GVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAKDYWEVHGHFGVAAGNYVG 235 Query: 238 AIWQPSEACEPYQDE-------------EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 + P+ Q E R + A+ +V + SG K Sbjct: 236 KWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIVAKCSGTNPTDVREESKPT 295 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 ++ +P + L++LQ EA ++ GLS++ LDI Q LYE HK+ TYPR+D +LPE++ A Sbjct: 296 AKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVTTYPRTDSSFLPEDYVAKA 355 Query: 345 HAVMNAISVHAPDLLPQPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 + + ++ + + V+D + +D+ K+ H AIIPT + LT E K Sbjct: 356 QSTIESLVGTTYEPHAKRVIDGGWVKPDKKIFDNGKISDHFAIIPTGKRPE-GLTPEEGK 414 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 VY++I R++L F P A ++ +A F + R L GW + G+ DE+ Sbjct: 415 VYDMIVRRFLAVFHPAAQYQVTTRITVVAGEHFKSSGRVLISEGWMAVYGADVDDEDKKT 474 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 L G+ + + E+ +T+PP +T+ TLL+AM +FV D +L ++ G Sbjct: 475 PALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLLAAMESAGKFVDDDELADAMKE-RG 533 Query: 522 LGTEATRAGIIELLF---------KRGFLTKKGRYIHSTDAGKALFHSLP----EMATRP 568 LGT ATRA IIE L K +L + G+ + T +L L E+ P Sbjct: 534 LGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLVPTPKLISLIEFLRNNGIELLASP 593 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR---QFRGIVAPGSGGS 625 +T WE L I + R F + Q+ID ++ + P GG Sbjct: 594 KLTGEWEHKLRLIERGEYRRDAFNNEIGDLTRQIIDAIRKKAAEVVVKKLDAKCPQCGGE 653 Query: 626 ADK 628 Sbjct: 654 IAI 656 >UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0YH06_9FLAO Length = 695 Score = 552 bits (1422), Expect = e-155, Method: Composition-based stats. Identities = 201/662 (30%), Positives = 312/662 (47%), Gaps = 49/662 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+ IAEKPS+AR IA +L H K DG++ GNG VTW +GHL+ P+ Y Sbjct: 1 MKAIIAEKPSVAREIAQLLGA-HEKKDGYL-SGNGYCVTWALGHLISLGMPEDYG--IRG 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 + A LPI P + L P+ KQLN I++ + + S I+ A D REG+ Sbjct: 57 FKKASLPIFPNPFILTPKKLKKAKGYEPDPSALKQLNTIQQVIKQCSSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YLQ + +R I+ L +A++ L+ F L +A AR+ AD Sbjct: 117 LIFRYIYHYLQC----NKPFERLWISSLTEKAIQDGFKNLQPGDAFDGLYQAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A TI G Q V S+GRVQTP L L+ +R + +NF + +F+++ Sbjct: 173 WLVGINATQALTI----GGNQDVYSLGRVQTPTLALICQRFLQHQNFTKQKYFQIQLSHR 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESESA 288 + + Q EE + AE + I AIV + K E + Sbjct: 229 KE--------YTDFTSLSLLQWEE-----KKQAEQIQKIIEREGRAIVEDVSVKTVQEQS 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL F L+ LQ EA ++ GLSA VL Q LYE ITYPR+ +Y+PE+ + ++ Sbjct: 276 PLLFDLTELQKEANRKLGLSADEVLQTAQSLYEKQ-FITYPRTGSKYIPEDLWTDIPELV 334 Query: 349 NAISVHAPDLLPQPVVD-PDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 ++ P + + R +D KV HH ++ T ++ + L+ E +Y++IA Sbjct: 335 RILNQTEPFKAAITHLKFGNFNKRIVNDVKVTDHHGLLITTKTPSA-LSATEKAIYDMIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE-----ENDGT 462 + L + I++ + +F K + GWR + G +E D T Sbjct: 394 YRLLESLSHTCTKQVTQIQIKVHHYEFQIKGSKILNKGWRAIKGILSDNENSNNANEDLT 453 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP GDEL K E++E+ TQPP+ +T+A LLS M R +++K+ +K L + G+ Sbjct: 454 ELPEFKIGDELKISKTELLEKTTQPPKLYTEADLLSVMENAGRSIENKEDQKAL-SNIGI 512 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQI 581 GT ATRA IIE L R ++ +K + +H TD G +++ + + MTA WE L +I Sbjct: 513 GTPATRASIIETLLSRNYIVRKSKTLHPTDKGLQVYNLVKDKKIANVQMTAEWEIALDKI 572 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKR--TPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 + + FM + ++ + P + P K K + Sbjct: 573 EKGELNKTQFMNDIQAYTAEITSELLSLHIPQENIPQLKCPKCQQHNLIIKDKIVKCPDE 632 Query: 640 KS 641 + Sbjct: 633 QC 634 >UniRef50_C6BT42 DNA topoisomerase type IA central domain protein n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BT42_DESAD Length = 720 Score = 551 bits (1419), Expect = e-155, Method: Composition-based stats. Identities = 240/661 (36%), Positives = 345/661 (52%), Gaps = 23/661 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEK +A AI+ L P R + NG +TW GH+L P+ +D RY Sbjct: 1 MRLFIAEKRDVALAISQALGGPDRPTGAAFQV-NGDRITWLWGHVLRLTDPEEHDERYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+L LP+ P L I H+A E+V+AGDPD EGQ LVDEV+++ Sbjct: 60 WDLNTLPMK-WPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAG 118 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 L + +R LIND N A+ +A+ + +NS++ L +SALARA D YG N+TR Y Sbjct: 119 L---LEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L + GYQGVLSVGRVQTP+LGLVV RD E + + VKA I P + A + Sbjct: 176 STLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMP-SQLVEAEY 234 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 P++ DE+GR+ + + N + GQPA V S PLP++L ALQ + Sbjct: 235 IPADDAPV--DEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQAD 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA + + VL+I Q+L + HK ITY RSDCRYL +E A ++ A++ D+ Sbjct: 293 AAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDM-- 350 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFCPDAV 419 P+++++ ++ KKV AHHAIIPT L E+E ++Y LI + Y+ QF A Sbjct: 351 AEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAE 410 Query: 420 FRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE--NDGTPLPVVAKGDELLCEK 477 F +EL IA KF A+ R + GWR L +D E L + + D E Sbjct: 411 FVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVES 470 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGTEATRA 529 E V+ T+PP +T +LL +T +A++V D ++KK+ D G+GT ATR Sbjct: 471 AESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRD 530 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 IE LF+RGF+ +K + + ST+ G+ +LPE A +PDMTA W QI + Y Sbjct: 531 SHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYL 590 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR-QFRGIVAPGSG-GSADKKKAAPRKRSAKKSPPADEV 647 ++ + G++ Q I + KR + + + P G +K K + P Sbjct: 591 QLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNA 650 Query: 648 G 648 Sbjct: 651 T 651 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 549 bits (1416), Expect = e-155, Method: Composition-based stats. Identities = 189/667 (28%), Positives = 309/667 (46%), Gaps = 45/667 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFI------ECGNGQVVTWCIGHLLEQAQPDAY 54 M + +AEKP AR +A PH KG+GF+ E NG VTW IGHL+E +P+ Y Sbjct: 1 MIVILAEKPDQARKLASPF--PHTKGNGFLSIQSCKEFPNGATVTWAIGHLVELKEPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + +W+LA LPI+P +++ + KQ +K+ L EA EI+ A DP REG+ + Sbjct: 59 RPEWKKWDLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEIIIATDPAREGENIARL 118 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 ++ +++++R + L A+ + L+ E + L A AR ADWL G+ Sbjct: 119 LILMAGC---SKKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHEAQARQIADWLVGM 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +R YT+L + G + V SVGRVQTPVL L+ R +EIE F + F+E++ Sbjct: 176 NASRLYTLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPFYELEGQFTVKNGT 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + + + + + + + A++ S + AP SL Sbjct: 236 YRGKLNKRFSSPDELYEAVSPDITKEQ--------QTYQAVIKSVRISEKRTPAPKLHSL 287 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S LQ + + S VL++ Q LYE ++YPR+D +Y+ EE + ++ Sbjct: 288 STLQSKLNRTKKFSPTKVLELVQSLYE-KGYVSYPRTDSQYITEEEYTYLQKHVDQYQQC 346 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN----LTENEAKVYNLIARQY 410 +P + P R + +KV H+AIIPT + + +E +VY I + Sbjct: 347 LGIHVPIRSLQPSKRY--VNPEKVSDHYAIIPTEKVPDTKAFETFSSDEKEVYYEILKSA 404 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT--PLPVVA 468 L F D V+ + VI + K +FV K R E GW+ L +++ +E LP V Sbjct: 405 LAMFMTDYVYDETVIITSVGKQEFVTKGRTEKEMGWKALYQNEKDEESEGEQVAILPEVK 464 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ V + TQPP+ +T L++ M ++V+D+++K+ L +GLGTEATR Sbjct: 465 EGESAKA-DISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALNQVEGLGTEATR 523 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCR 587 A II+ L +R + K + T G+ L ++ + ++P+MTA WE L +I + Sbjct: 524 AAIIDTLIQRRLIEVKKNQVFVTKKGEILCEAVKGTILSKPEMTAKWELFLQEIGKGNRS 583 Query: 588 YQDFMQPLVGTLYQLIDQAK------------RTPVRQFRGIVAPGSGGSADKKKAAPRK 635 + F++ Y LI QA ++ P + + Sbjct: 584 KEVFIEQAKKLCYALIQQASQDVERIDAKQALEEIKKENTIAPCPRCQKGYIVDR---KT 640 Query: 636 RSAKKSP 642 Sbjct: 641 FYGCTEY 647 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 549 bits (1416), Expect = e-155, Method: Composition-based stats. Identities = 197/687 (28%), Positives = 326/687 (47%), Gaps = 65/687 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+AR I L + + G VVT +GH+LE PD + + +W Sbjct: 5 LVITEKPSVARDITRALGGFQNEKN--FFEGPEHVVTSAVGHMLELVAPDGVEVQRGKWA 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +LP++P+ + L+P QL +IK+ + +++A D REG+L+ ++ + + Sbjct: 63 LVNLPVIPDHFDLKPIQQNESQLKLIKKLYARKDIDSVINACDAGREGELIFHYLIRHFK 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + V+R + + PQA+ +RLR +PL +A+ R+ +DWL GIN TRA Sbjct: 123 GS----KPVRRLWLQSMTPQAIRDGFERLRDGETLLPLQRAAVCRSESDWLIGINATRAM 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T L + G + +VGRVQTP L L+V R++EI++F ++++EVKA + R+ W Sbjct: 179 TALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPREYWEVKAIFAIASG-RYEGYW 237 Query: 241 QPSE--------------ACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 + + + R+ + AE +V + + + V+ K S+ Sbjct: 238 VDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIVAQCANREGRVSE-TTKPSSQ 296 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P+ F L++LQ EA +RFG SA+ L I Q LYE HK++TYPR+D R LPE++ Sbjct: 297 QPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVLTYPRTDSRTLPEDYPKTVGT 356 Query: 347 VMNAI-------------------SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT 387 +M ++ H + + Q R +++ +V H AIIPT Sbjct: 357 IMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYINGKNRRIFNNAQVSDHFAIIPT 416 Query: 388 ARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWR 447 + L E E ++Y L+ R ++ F P A F V + F + R L E+GW Sbjct: 417 GEAP-GKLKEQERRIYELVTRCFIAAFYPPARFENTVRRTVVEHQTFETRGRVLIESGWL 475 Query: 448 TLLGSKERDEENDGTPLPVVA-----KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 ++G KE +E LP +A + + ++ +QT+ P + +ATLLSAM G Sbjct: 476 QVMGRKESNE-----TLPPLASTAQDDSERAETVEIDLEGKQTKAPPRYNEATLLSAMEG 530 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 + ++D +L++ L GLGT ATRA IIE L + ++ + R + T L L Sbjct: 531 AGKLMEDDELREAL-QGRGLGTPATRAAIIEELIRNRYILRDARELIPTAKATTLLRLLR 589 Query: 563 ----EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI- 617 + T ++T WE L QI Q ++FM+ + +++ A++ V Q Sbjct: 590 ALKIDELTTAELTGEWEKKLKQIESDQFSSEEFMRHIRRMTADIVEAARQCDVDQIDDEY 649 Query: 618 -----VAPGSGGSADKKKAAPRKRSAK 639 P G ++ + Sbjct: 650 AVLAVPCPKCGQGRVRENYRKFVCESC 676 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 549 bits (1414), Expect = e-154, Method: Composition-based stats. Identities = 136/675 (20%), Positives = 252/675 (37%), Gaps = 82/675 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G V GH+ ++ Sbjct: 5 LVIVESPAKAKTIEKFLG-------------PGYKVLASYGHVRALPSKQGSVDVEHNFS 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P K + ++K+ ++ E++ A DPDREG+ + +L+ L + Sbjct: 52 PL----------YHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGID 101 Query: 123 PEKRQQ-VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + V+R +++ A++ AI + L + AR+ D+L G N++ Sbjct: 102 ENAKSPEVKRVTFHEITKGAIQEAIS--KPGHIARELVDAQQARSILDYLVGFNLSPFLW 159 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L L+ R++EI+ F A++++ ++ + T F A Sbjct: 160 KKIRYG-----LSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLY 214 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + + + A +V I + V + + PF+ S LQ EA Sbjct: 215 AVDGNSLGKFD---INQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEA 271 Query: 302 AKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +++ G SA+ + + QKLYE LITY R+D L + ++ + + Sbjct: 272 SRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRM--Y 329 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D +D + +AH A+ PT+ S+ + L+ ++ K+Y LI ++ Sbjct: 330 GEDYA----LDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQR 385 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEEN----DGTPL 464 + A +++ + F A + + G+ L +E+ + L Sbjct: 386 TVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTL 445 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + + L C++ + + TQPP FT+A+L+ + G+G Sbjct: 446 PPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLEE-----------------HGIGR 488 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQI 581 +T A II L R ++ + R ++ D G + L D TA E L I Sbjct: 489 PSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAI 548 Query: 582 SEKQCRYQDFMQPLVGTL-----YQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKR 636 S + +Q ++ + +K+ + + P G K + Sbjct: 549 SRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRF 608 Query: 637 SAKKSPPADEVGSGA 651 A P Sbjct: 609 LACSGFPDCRYTEPL 623 >UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62_9FIRM Length = 709 Score = 548 bits (1412), Expect = e-154, Method: Composition-based stats. Identities = 203/651 (31%), Positives = 313/651 (48%), Gaps = 56/651 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L +AEKPS+A +++ V+ R GDG++E GNG +V+WC+GHL+E +QP+AYD +YA+ Sbjct: 18 MKLVLAEKPSVAMSLSKVIGADQR-GDGYME-GNGYLVSWCVGHLVELSQPEAYDEKYAK 75 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+PE WQ Q S KQ ++K+ + + ++ A D REG+L+ V Sbjct: 76 WKYDDLPILPEHWQYQVSASTKKQFGILKKLMQRKDVESLICATDAGREGELIFRLVYHQ 135 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ + A+ +LR +E+ L +AL R RADW+ GIN TR Sbjct: 136 CGC----KKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATR 191 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++ L Y L+VGRV TP L +VV RD I F + F+ + Sbjct: 192 LFSCL-----YGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKF---------- 236 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNR-ISGQPAIVTSYNDKRESESAPLPFSLSAL 297 +Q R+ + AE +V AI+T K +SE P F L++L Sbjct: 237 --------RDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSL 288 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA ++ G +AQ LD Q LYE KL+TYPR+D RYL ++ +++ I Sbjct: 289 QREANRQLGFTAQQTLDYTQALYE-KKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQ- 346 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS---SAINLTENEAKVYNLIARQYLMQF 414 + P + + KKV HHAIIPT + +L E + ++ + + Sbjct: 347 -IQPDAPAPVNTAQVINTKKVTDHHAIIPTKTAAGYDISSLPSGEQAILTMLTVRLICAV 405 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVVAKGDE 472 + + ++E + A KF K + + + GWR G D E + LP++++G Sbjct: 406 GTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGKAVEDAEKNAEAGELPILSEGMT 465 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L ++ E +T PP+ FT+ LLSAM + D+ + G+GT ATRA II Sbjct: 466 LELAGVDLKEGKTSPPKRFTEDLLLSAMESAS---SDEFPAGV--ERKGIGTPATRAAII 520 Query: 533 ELLFKRGFLTKKG----RYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRY 588 E L ++GF+ ++G +Y+ STD G AL +PE P MTA WE L +I + Sbjct: 521 EKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDS 580 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIV-------APGSGGSADKKKAA 632 FM + + L+ + P G + Sbjct: 581 DAFMGEISSMVSGLVKTYEAVKGADVLMQPECKVIGSCPACGSDVCETAKG 631 >UniRef50_Q9F544 YdgA protein n=19 Tax=Enterobacteriaceae RepID=Q9F544_ECOLX Length = 718 Score = 547 bits (1410), Expect = e-154, Method: Composition-based stats. Identities = 231/663 (34%), Positives = 350/663 (52%), Gaps = 41/663 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP++A I L + DG+ E + +VT C GH++E P+ Y+ Y Sbjct: 1 MKLFIAEKPAVANDIVKALGGNFTRHDGWFES-DNTIVTNCFGHIIESQPPENYNPEYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W + LP+ + QP S KQ+ I + A EI+HAGDPD EGQLLVDEVL+Y Sbjct: 60 WKIETLPLRLYPVKYQPVESAEKQVKTIIELIRRADVTEIIHAGDPDDEGQLLVDEVLEY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + V+R LIND AV++A+ ++N +F L + ALAR+ AD +YG++MTR Sbjct: 120 AG----NTKPVKRVLINDNTLPAVKKALANPKNNRDFRGLYLKALARSVADAIYGLSMTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI + GY+GVLSVGRVQTPVLGL+V R +N + ++ + H + A Sbjct: 176 AYTIPAKTKGYKGVLSVGRVQTPVLGLIVNRTRANKNHKSSFYYTMTGHFQR-GADVIRA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W+P E + LL + A ++G+PA V + + +APLPF+L LQ Sbjct: 235 NWKPGEFAPLTDRK---LLDKTWANGTATSLAGKPATVEAAATDDKKTAAPLPFNLVRLQ 291 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 K+F ++AQ LDI Q+L E +K ITY RSDC YL +E F+ +++A+ Sbjct: 292 QYMNKKFKMTAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQIIDALKSVFDQP 351 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQFCPD 417 + +D +++ ++ KV AH AIIPT +N L+ +E VY IA+ YL+QF P+ Sbjct: 352 MD---IDTTRKSKAFNSAKVTAHTAIIPTVSVPDVNALSTDERNVYLAIAQHYLVQFMPE 408 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE--------RDEENDGTPLPVVAK 469 +++ + + F A+AR ++G+ LG + ++++D L + Sbjct: 409 KAYQEVSVAIQCGDESFYARARKTTDSGFEAFLGVENAGDDEAEVENDDSDFDLLCKIRT 468 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 G+ + ++ V E++T PP FT+ATLL+A+ +A FV D +KK+L+ D G Sbjct: 469 GETVTTKEVVVNEKKTTPPPLFTEATLLAALVRVADFVTDPVIKKLLKEKDRDKKDEHGG 528 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 +GT ATRA I+E L KR ++T + + TD G AL +LP++A PDMTA W T I Sbjct: 529 IGTPATRASILETLKKRNYITLEKGKLIPTDTGYALIDALPDIAVNPDMTALWAEKQTLI 588 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR----------QFRGIVAPGSGGSADKKKA 631 + + F+ L L +I A ++ Q P G + Sbjct: 589 ENGEMTIEQFVDELYNDLIPMISNANSAEIKVSPSAPSGQSQRLSSPCPSCGKQIVIRPK 648 Query: 632 APR 634 + Sbjct: 649 SYS 651 >UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW2_ROSCS Length = 836 Score = 547 bits (1410), Expect = e-154, Method: Composition-based stats. Identities = 139/691 (20%), Positives = 260/691 (37%), Gaps = 100/691 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ AR I L +G V +GH+ + + + A + Sbjct: 4 KLVIVESPAKARTIQKYLG-------------SGYRVEASMGHVRDLPKSNLGVDLEANF 50 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + P K + +++ + +A + A DPDREG+ + + + ++ Sbjct: 51 APV----------YEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKI 100 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + V R + ++ P AV A+ R L + AR D L G ++ Sbjct: 101 --PRDKPVYRVVFTEITPGAVRSAMASPRDIDR--RLVDAQQARRVLDRLVGYKLSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA-----DERF 236 R LS GRVQ+ + L+V R+ EIE FV ++++ ++A ++ + F Sbjct: 157 EKVRRG-----LSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAF 211 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A+ + E+ + A+ ++ + G IV + + S PF+ S Sbjct: 212 RAMLIERSGKKL---EKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTST 268 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE---------THKLITYPRSDCRYLPEEHFAGRHAV 347 LQ EA ++ G SA+ + + Q+LYE LITY R+D + E V Sbjct: 269 LQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRV 328 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKV 402 + LP + + +AH AI P T LT ++ ++ Sbjct: 329 IRE--RFGEAYLPAKPPVYKTKAK----GAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRL 382 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIA-----------KGKFVAKARFLAEAGWRTLLG 451 Y+LI ++++ AVF V+++ F A L G+ + Sbjct: 383 YDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYN 442 Query: 452 ---SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 + ++E+ LP++ +G+ L + V+ T+PP FT+A+L+ + + Sbjct: 443 VSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLG---- 498 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--- 565 +G +T A I + +R ++ + + T G+ + L E Sbjct: 499 -------------IGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSI 545 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV-----RQFRGIVAP 620 T+ E L I+E + + ++ Q + +A+R+ + P Sbjct: 546 VDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCP 605 Query: 621 GSG-GSADKKKAAPRKRSAKKSPPADEVGSG 650 G K + A P + S Sbjct: 606 RCNQGQLAVKFGRNGEFLACNRYPECDFTSD 636 >UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1_CLOD6 Length = 696 Score = 546 bits (1408), Expect = e-154, Method: Composition-based stats. Identities = 192/667 (28%), Positives = 304/667 (45%), Gaps = 64/667 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS+A+ IA VL +K DGF+ G+G +V+WC+GHL+ A+ AY +Y + Sbjct: 1 MILVIAEKPSVAQTIAAVLGVKEKK-DGFL-TGSGYIVSWCVGHLVGLAEAAAYGEQYKK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 WN LPI+P++W+ KQ +K +H A E+V+A D REG+L+ V + Sbjct: 59 WNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEM 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ ++R I+ + A++ RL++ E+ L SAL RA+ADWL GIN TR Sbjct: 119 AGC----KKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +++L Y L+VGRVQTP L ++V RD I F + ++ V+ + Sbjct: 175 LFSVL-----YNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAAS--- 226 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 R+ ++ A+ + A+ TS ++++ + P F L++LQ Sbjct: 227 ---------------ERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQ 271 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA FG +A+ LD+ Q LYE L+TYPR+D YL ++ ++ + P + Sbjct: 272 REANCLFGYTAKQTLDLAQALYEKR-LLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFM 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL---TENEAKVYNLIARQYLMQFC 415 + + + KKV HHAIIPT + +L E+E + + + +M Sbjct: 331 AGKDFTPELAK--VLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATA 388 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL----------LGSKERDEENDGTPLP 465 F + A F A+ + + GW+ + + + + LP Sbjct: 389 APHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLP 448 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 +G +V E T PP+ +A+LLSAM D D GLGT Sbjct: 449 PFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDA-----ERKGLGTP 503 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQ 585 ATRA +IE L K GF+ +KG+ + T G L LP+ T P +TA WE+ LTQI++ + Sbjct: 504 ATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGK 563 Query: 586 CRYQDFMQPLVGTLYQLIDQAK--------RTPVRQFRGIVAPGSGGSADKKKAAPRKRS 637 FM+ + +L+ R + P G +K Sbjct: 564 ADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVY----EGKKNY 619 Query: 638 AKKSPPA 644 + Sbjct: 620 YCSNKEC 626 >UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamiensis G4 RepID=A4JW73_BURVG Length = 823 Score = 546 bits (1408), Expect = e-154, Method: Composition-based stats. Identities = 197/660 (29%), Positives = 306/660 (46%), Gaps = 48/660 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L +AEKPS+A IA L K DG+ E + +V GHL+EQ P A W Sbjct: 5 LIVAEKPSVAADIAKALGG-FTKADGYFER-DDAIVAPARGHLVEQTVPAA--DAKGMWK 60 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 + LPI+P+ ++L+ T + + +K+ + +V+A D REG+L+ + + Sbjct: 61 IGVLPIIPDSFELEVIDGCTAEFSRLKKLMARDDVASVVNACDAGREGELIFRLIYNKAG 120 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ +R I + A+ +A D LR +EF L +A R+ ADW+ G+N TRA Sbjct: 121 C----RKPTKRMWIQSMVASAIRKAHDDLRPGAEFDHLSDAAFCRSEADWIVGVNGTRAT 176 Query: 181 TILGRNAGYQGVLS-VGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L + +S VGRVQTP L + V R+ EI FVA+D++E+ A Sbjct: 177 TALRERKTQRREVSPVGRVQTPTLAMPVIREREIAAFVARDYWEIHGTFRAEAGTYVAKW 236 Query: 240 WQPSEACEPYQDEEG-----------RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESA 288 ++ + EG R + A+ +V++ G K E A Sbjct: 237 IGDADGDTSPAETEGDAEAEAEQTGARCFDKAKAQAIVDKCKGVDPSSVVDESKPEERPA 296 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 P F L+ALQ EA KRF SA+ LDI Q LYE HK TYPR+D R LPE++ A + Sbjct: 297 PALFDLTALQREANKRFKFSAKKTLDIAQALYEKHKATTYPRTDSRALPEDYLETAAATL 356 Query: 349 NAISVHAPDLLPQPVVDP---DIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 + + Q V++ R +++ + H AI+PT + L+ +E K+Y+L Sbjct: 357 ATFASTPLEAHAQRVIENGWVKPDKRIFNNADISDHFAIVPTGQQPD-GLSSDEQKIYDL 415 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 ++R+++ F P A + K V +A F + L E GW + G K D+ L Sbjct: 416 VSRRFIAVFHPSAKYEKTVRTTIVAGETFRTSGKVLVEPGWLAVYGEKAHDD--TAAALC 473 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 VA G+ + + E+ QT+PP+ +T+ATLL+AM R V+DKD++ ++ +G+G Sbjct: 474 KVADGEAVTADAIELKALQTKPPKRYTEATLLAAMENAGRQVEDKDIRAAMK-ANGIGRP 532 Query: 526 ATRAGIIELLFKRG---------FLTKKGRYIHSTDAGKALFHSLPE----MATRPDMTA 572 ATRA IIE L + +L + + T L L E P MT Sbjct: 533 ATRAAIIEGLLEDKDKNDNPKEPYLRRDDNELVPTPKAMELIAFLEEAGIDFLVSPQMTG 592 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR------TPVRQFRGIVAPGSGGSA 626 WE L ++ + R FM + +++ + PV + P G + Sbjct: 593 EWEQKLLRMEKGDYRRSTFMSEIADLSTGMVETIRAKYNELPEPVAKALDAPCPRCGAAV 652 >UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_SYMTH Length = 735 Score = 546 bits (1406), Expect = e-153, Method: Composition-based stats. Identities = 141/698 (20%), Positives = 262/698 (37%), Gaps = 105/698 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + V +GH+ + + S + Sbjct: 5 LIIVESPAKAKTIEKFLGRK-------------YAVKASMGHVRDLPKSQLGVSVENDFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + L ++ +A + A DPDREG+ + + L+L Sbjct: 52 P----------KYITIRGKGDILKELRESARKADRVYLATDPDREGEAISWHLAQVLKLP 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ R +++ A++RAI + R + + AR D L G ++ Sbjct: 102 LDEPL---RIEFHEITKDAIQRAIKQPRPID--LNRVEAQQARRVLDRLVGYKLSPLLWR 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ + L+V R+ EI+ F ++++ + A + T + F+A + Sbjct: 157 KVRRG-----LSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWG 211 Query: 243 SEACEPYQDEEGRL--------LHRPLAEHVVNRISGQPA----------------IVTS 278 + + ++ R A + G P V S Sbjct: 212 MGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRS 271 Query: 279 YNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYET--------HKLITYPR 330 + + + PF+ S+LQ EA+++ G S + + + Q+LYE L+TY R Sbjct: 272 VKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIR 331 Query: 331 SDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS 390 +D + +E + + D +P+ +PD R + AH AI PT + Sbjct: 332 TDSTRIADEAARAAAEFIER--QYGKDYVPERRREPDRR-----AGEQGAHEAIRPTDVT 384 Query: 391 SAIN-----LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAG 445 LT ++ ++Y LI ++L AV +EL + F A + + G Sbjct: 385 RTPESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPG 444 Query: 446 WRTLLGSKERDE---ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTG 502 + + E D+ E LP +A+G ++ + E + TQPP +++A L+ A+ Sbjct: 445 FMKVYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEE 504 Query: 503 IARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP 562 G+G +T A II + RG++ K+ + + T+ G + L Sbjct: 505 -----------------RGIGRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILK 547 Query: 563 EMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV-----RQF 614 E + TAH E L ++ E + +++ ++ G + + QA+ + Sbjct: 548 EYFPDIIDVEFTAHLEGKLDEVEEGRVNWRELIRRFYGPFEETLKQAEEKVGGFELEDEV 607 Query: 615 RGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 + G K K A P + + Sbjct: 608 SDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPIL 645 >UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q185E5_CLOD6 Length = 706 Score = 545 bits (1405), Expect = e-153, Method: Composition-based stats. Identities = 191/652 (29%), Positives = 312/652 (47%), Gaps = 47/652 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L +AEKPS+ R IA VL + K +G+IE G V+TW +GHL+ A P++Y RY W Sbjct: 4 ILVLAEKPSVGRDIAKVLGSKNEK-NGYIE-GPKYVITWALGHLVTLADPESYGERYKSW 61 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYL 119 +L DLPI+P+ + KQ N +K ++ + EIV A D REG+L+ +++ Sbjct: 62 SLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIE-- 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++ ++R I+ +A++ +L+S E+ L SA+ARA ADW+ GIN TRA Sbjct: 120 --KSQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRA 177 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T Y LS GRVQTP L ++++R+EEI NF K+++ ++ I T + I Sbjct: 178 LTTK-----YNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLEL-IATKGNSDIKFI 231 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + E + ++ G ++ N + + +P + L+ LQ Sbjct: 232 WNDKNNNSST-------FSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQR 284 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A K FG SA+ L I QKLYE HK++TYPR+D RYL + + A+++ + Sbjct: 285 DANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKI 344 Query: 360 PQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLIARQYLMQFCP 416 ++ + D+ KV HHAIIPT + + ++ E K+YNL+ +++L P Sbjct: 345 CNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSP 404 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 + + I + F AK + GW+ K+ ++E++ +P V + D L + Sbjct: 405 PFEYEQTTISATVEGEIFKAKGNKVINLGWKESY--KDIEDEDEYESIPNVLEKDVLKVK 462 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 ++ +T PP + + TLL+AM +GLGT ATRA IIE LF Sbjct: 463 GLKITSGKTNPPPYLNEGTLLTAMEK-----------------NGLGTVATRADIIEKLF 505 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + KK + I+ T G+ L +P P++TA WE L IS+ + F+ + Sbjct: 506 NSFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMK 565 Query: 597 GTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 ++ + K + + P G + K + Sbjct: 566 DYSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDREC 617 >UniRef50_A7HZT1 DNA topoisomerase 3 (DNA topoisomerase III) n=3 Tax=Campylobacter RepID=A7HZT1_CAMHC Length = 716 Score = 545 bits (1404), Expect = e-153, Method: Composition-based stats. Identities = 206/698 (29%), Positives = 344/698 (49%), Gaps = 66/698 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+LFIAEKP+LA++IA + ++ GDGF + G ++TW GHLLE P+ YD + + Sbjct: 1 MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGEN-IITWAFGHLLELYMPEDYDENFKK 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W+L DLP+ ++++ +P S +QL +I + + I++ GD D EGQ+L+DE+L Y Sbjct: 60 WDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKRSDVDTIINCGDADEEGQILIDEILKY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V R L++DL + V + ++SN++F L AR+ ADW+ GIN+TR Sbjct: 120 A----NNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINLTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT +N GY+GV+SVGRVQTP+LGLVV RD E E + ++ + T E Sbjct: 176 AYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEILA- 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + ++ A + N G+ + + ++ + E PLP++L LQ Sbjct: 235 ----------NLKTDEKITDENEANEIKNICLGKNG-ILNVTNENKLEYPPLPYNLLNLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + +K+F L I Q L E +K ITY RSDC YLP + V+N+I + D Sbjct: 284 ADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLSDF 343 Query: 359 LP-QPVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFCP 416 DP++++R ++D+ + AH AIIPT + +++++E VY LI+++Y+ QF Sbjct: 344 ENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIAQFYE 403 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------GSKERDEENDGTPLPVVAKG 470 + + IE+ I KF + + + G+ +L K DE + L ++ G Sbjct: 404 PMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDDEVENSFDLSLLESG 463 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK--------KILRATDGL 522 E+ ++QT+P ++T TLL +T I+++V+D+ +K G+ Sbjct: 464 -NCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKKGENGGI 522 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQIS 582 GT ATR+ I+ LF+R ++ ++ + I ST G+ L P++ + PDMTA W +I Sbjct: 523 GTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYEQQLEIQ 582 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGI----VAPGSGGSADKKK---AAP 633 DF+ + + + I+ K + + F GI G +K+ Sbjct: 583 NGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGIDKTYPC-KCGKGFLQKRHSQKTG 641 Query: 634 RKRSAKKSPP--------------------ADEVGSGA 651 + + + GS Sbjct: 642 KDFWGCSNWKNGCSEIYPDLNGKPNIPKYFCPKCGSAL 679 >UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRI8_9FIRM Length = 713 Score = 544 bits (1403), Expect = e-153, Method: Composition-based stats. Identities = 127/675 (18%), Positives = 259/675 (38%), Gaps = 87/675 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I L K V +GH+ + + + Sbjct: 17 HLVIVESPAKAKTIEKYLGK-------------DYSVVASVGHIRDLPKSKLGVDVDNNF 63 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + + + +K+ + + A DPDREG+ + + L + Sbjct: 64 EP----------KYENKKDKAALIKELKKDAKASDIVYLATDPDREGEAISWHLAHVLGI 113 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 +P+ R +++ +E + R+ + L + AR D + G ++ Sbjct: 114 SPDAPV---RVTFSEITKSGIEAGMSHPRTLD--MDLINAQQARRILDRIVGYKLSPFLW 168 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI-VTPADERFTAIW 240 R LS GRVQ+ + L+V R++EIE+F A++++ + A + + F A Sbjct: 169 KKVRRG-----LSAGRVQSVAVRLIVDREQEIESFEAQEYWSIDAKLLSASSRRAFPAKL 223 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E+ + L++ + V+ + I+T+ + ++ PF+ S LQ E Sbjct: 224 T------EVKGEKFKALNKEETDKVLAMLENGEFIITNIKNSTRKKTPAPPFTTSTLQQE 277 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A+++ +A+ + Q+LYE +ITY R+D + +E A ++ + Sbjct: 278 ASRKLSFNARRTMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMIEST- 336 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + LP R + DAH AI PT + L+ ++ K+Y LI Sbjct: 337 -YGKEYLP-----SKPRVFKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLYKLIW 390 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 +++ + + +++ + F A + G+ L + ++E +G LP + Sbjct: 391 ERFMASQMENQLLDTKAVDITCGECLFKANGYTVKFDGFTKLYEESKDNDEEEGGALPAL 450 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G++L ++ + TQPP +T+A+L+ A+ +G+G +T Sbjct: 451 EVGEKLKVKELTGNQHFTQPPPRYTEASLIKALEE-----------------NGIGRPST 493 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEK 584 A I + R ++ ++ + + T G + + E TA ES L +I Sbjct: 494 YAPTIATILDRHYVEREAKQLKPTSLGIVITDLMKGHFERIVDAKFTAQMESDLDKIEAG 553 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKR-------TPVRQFRGIVAPGSGGSADKKKAAPRKRS 637 + + D + +++ +A++ + IV G K K Sbjct: 554 KADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKIPDEPTDIVCDKCGKPMVIKIGPYGKFL 613 Query: 638 AKKSPPADEVGSGAI 652 P + + Sbjct: 614 GCSGFPECKNTKRIV 628 >UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0_9FIRM Length = 703 Score = 544 bits (1403), Expect = e-153, Method: Composition-based stats. Identities = 203/665 (30%), Positives = 313/665 (47%), Gaps = 59/665 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKPS++RAIA+V+ + DG+++ G +V+WC GHL E PDAYD ++ + Sbjct: 1 MYLVIAEKPSVSRAIAEVIGA-QEREDGYLQ-GTDCMVSWCFGHLAEYVSPDAYDEKFNQ 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W DLPI+P+ W++ Q ++KR L+ E +V+A D REG+L+ V D Sbjct: 59 WRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDL 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ L A+ + LRS E+ L +A+ R++ADWL G+N TR Sbjct: 119 SG----SKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYT L+VGRVQTP L ++V R +I NF + +F V+ Sbjct: 175 AYTTKYFKK-----LTVGRVQTPTLAMLVERAGQISNFQKEKYFNVEL------------ 217 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 C+ + ++ AE + +R G AIVT+ + + AP + L+ LQ Sbjct: 218 ------DCDGIPAVKPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTLQ 271 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA + +G++A+ LD Q LYE KLITYPR+D +YL E+ V+ I Sbjct: 272 REANRIYGMTAKQTLDTAQSLYE-KKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLT 330 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA---INLTENEAKVYNLIARQYLMQFC 415 P + + ++ KV HHAIIPT ++ L E K+ LIA +M Sbjct: 331 GPFDQPEQPDVKKVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLIAVHTVMAMS 390 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE--------RDEENDGTPLPVV 467 D ++++ IE++ + F AK + + + GW+ + ++ +P V Sbjct: 391 KDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPKV 450 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G E E T PP+ +++ TLL+AM D+D +K GLGT AT Sbjct: 451 TQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEK-----KGLGTPAT 505 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 RAGIIE L + T+KG+ I TD GK L LP+ MTA WE+ L + + Sbjct: 506 RAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQLLLMEHGEIA 565 Query: 588 YQDFMQPLVGTLYQLI-------DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 + FM + L ++ ++ R + P G + K Sbjct: 566 PEQFMTGIKNMLTMMLNGCDAISEEETRRFQTRESIGTCPVCGSLVYESKTN----FYCS 621 Query: 641 SPPAD 645 + Sbjct: 622 NHDCH 626 >UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID=B1HX02_LYSSC Length = 725 Score = 544 bits (1402), Expect = e-153, Method: Composition-based stats. Identities = 204/687 (29%), Positives = 319/687 (46%), Gaps = 59/687 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIEC------GNGQVVTWCIGHLLEQAQPDAY 54 M++ IA KP A +A G+ E NG ++TW GHL E P+ Y Sbjct: 1 MKIVIAAKPDQAAKLAAPWS--FTIKTGYFEVKANSYFPNGAIITWATGHLCELKTPEEY 58 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLV 112 DS + +W L LPI+P++++ + S KQ +IK + A EI+ GD REG+L++ Sbjct: 59 DSTWKKWKLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQEIIIGGDAGREGELII 118 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 +L + + ++R I+ L +V+ L ++ + AL+R+ ADWL Sbjct: 119 RTILRVCGV----NKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIYYEALSRSCADWLI 174 Query: 173 GINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 GIN +R YT+L + G + V S+GRVQTP L L+V R+ EI NF ++ F+EV+A Sbjct: 175 GINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSEPFWEVEAVFHFAG 234 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 A W +++ R+L A + N + +T + + + PL F Sbjct: 235 KM-LKAKW--------HKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKEYAPPLLF 285 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +LS LQ A K + S Q LDI QKLY L++YPRSD ++L E ++N +S Sbjct: 286 NLSGLQATANKAYKFSPQKTLDILQKLYV-KGLVSYPRSDSQFLTSEEAKTLPTILNNLS 344 Query: 353 VH--APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQ 409 +LLP P+ R ++KKV HHAII T + L+ E K+Y+L+ARQ Sbjct: 345 KMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTEQMPNLSKLSMEEEKIYDLVARQ 404 Query: 410 YLMQFCPDAVFRKCVIELDIAKG-KFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVV 467 + A+F I + K +F++K + E GWR + +K+ + + LP++ Sbjct: 405 VIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQEEEEMLPLL 464 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + + + V + TQPP +++ L++ M + + D +L+K+L T+GLGTEAT Sbjct: 465 HENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSKTEGLGTEAT 524 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQ 585 RAGII L R ++ K + +T G L +L + T P MTA WE L +I E Sbjct: 525 RAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGENSLLTSPSMTAKWEQRLAEIGEGH 584 Query: 586 CRYQDFMQPLVGTLYQLIDQA------------------------KRTPVRQFRGIVAPG 621 Q FM+ + Y+LI A K+ + Sbjct: 585 ASPQAFMEQVKKLTYKLITDAHEREKAWTFDQKEVEKISANNPYQKKYKKEKTVVGKCIL 644 Query: 622 SGGSADKKKAAPRKRSAKKSPPADEVG 648 GS + A Sbjct: 645 CNGSII----DHGTFYGCSNYKAANCK 667 >UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D1W4E5_9BACT Length = 714 Score = 544 bits (1401), Expect = e-153, Method: Composition-based stats. Identities = 192/658 (29%), Positives = 304/658 (46%), Gaps = 49/658 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+ IAEKPS+AR IA ++ ++ +G+ E G G VTW GHL++ A PD Y Sbjct: 20 MKTIIAEKPSVAREIARIVGA-TKREEGYFEGG-GYAVTWAFGHLVQLAMPDGYG--VRG 75 Query: 61 WNLADLPIVPEKWQ-----------LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + +LPI+P+ + +P V Q+ VIKR + I+ A D REG+ Sbjct: 76 FVRDNLPIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDTSEHIIVATDAGREGE 135 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + Y R I+ L +A+ + +L S++ L ++A AR+ +D Sbjct: 136 LIFRYLYHYTGCTT----PFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKARSESD 191 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A +I G SVGRVQTP L +V R E F ++ F+ + HI Sbjct: 192 WLVGINGTQALSIAA----GHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLL--HIA 245 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 T + + SE + + A + N++ A VT K ++E Sbjct: 246 TDGCDGEVVKFSSSEKWK----------EKEPAMELYNKVKAAGCATVTKAERKEKTEET 295 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA + G +A+ L+I QKLYE KLITYPR+ RY+PE+ FA ++ Sbjct: 296 PLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYE-KKLITYPRTGSRYIPEDVFAEIPKLL 354 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 I P+ + R DD KV HHA++ T L++ + +Y +IA Sbjct: 355 AFIGTQ-PEWKDKVRAKAAPTRRSVDDGKVTDHHALLVTGEKPLF-LSKEDNTIYQMIAG 412 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + F V + + A +F K + + GWR + G EE + +P Sbjct: 413 RMVEAFSEKCVKDVTTVTAECAGVEFTVKGSVVKQTGWRAVYG-----EEKEEITIPGWQ 467 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GD L + + E +T+P T+ATLLSAM + ++D L++ ++ G+GT ATR Sbjct: 468 EGDTLTPKGSSITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATR 526 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQISEKQCR 587 A IIE LFKRG++ + + + T+ G AL + M MT WE L +I + Sbjct: 527 ASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWEKELARIERGELS 586 Query: 588 YQDFMQPLVGTLYQLIDQA---KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 F + + ++ + + + G P G + + + Sbjct: 587 ADTFRKEIEAYTREITSELLSCDKLFGSRDSGCACPKCGTGRMRFYGKVVRCDNTECG 644 >UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID=TOP3_STAEQ Length = 711 Score = 543 bits (1400), Expect = e-153, Method: Composition-based stats. Identities = 185/657 (28%), Positives = 309/657 (47%), Gaps = 43/657 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L +AEKPS+ R IA+ L +K +G+IE G +VTW +GHL+ A P+ Y+ Y Sbjct: 1 MKSLILAEKPSVGRDIANAL-NLQQKSNGYIE-GKQYIVTWALGHLVTNATPEQYNPSYK 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 WNL DLPI+P+K + +Q ++K + EI+ A D REG+L+ +LD Sbjct: 59 EWNLEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILD 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + ++ ++R I+ + +A++ +L++ + + L +ALAR+ ADW+ GIN T Sbjct: 119 KVG----NKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINAT 174 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T Y LS+GRVQTP + +V R +EI F + ++ + ++ Sbjct: 175 RALTTK-----YDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINV--------- 220 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + ++ R + E + ++I Q + K + A F+L+ L Sbjct: 221 ------DGYDLNLKQQKRYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLTDL 274 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA K + + + L+ Q LYE HKL+TYPR+D YL ++ + AI Sbjct: 275 QQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATDYK 334 Query: 358 LLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 + ++ + ++++KV HHAIIPT +I L++ E K+Y LIA ++L Sbjct: 335 SHVRDLISESFSSKMHIFNNQKVSDHHAIIPTEVRPSIEQLSQREFKIYMLIAERFLENL 394 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 ++ I + FV K + G++ L +D+ + T +G Sbjct: 395 MNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKAL-----KDQTSSHTLTHSFKEGQLFK 449 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGII 532 + E+ E +T+ P +F + +LL AM + DK K L+ + G+GT ATRA II Sbjct: 450 VHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRADII 509 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFM 592 E LF L + I T GK + P T P +TA WE L I + + Q F+ Sbjct: 510 EKLFNMNALESRDGKIKVTSKGKQILELSPSELTSPILTAQWEEKLMLIEKGKYNSQKFI 569 Query: 593 QPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 Q + ++++++ K + + P G K K + + P Sbjct: 570 QEMKNFTFKVVNKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCK 626 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 541 bits (1395), Expect = e-152, Method: Composition-based stats. Identities = 149/668 (22%), Positives = 259/668 (38%), Gaps = 87/668 (13%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L I E P+ AR ++ L + +V +GH+ + + + Sbjct: 1 MKHLIIVESPAKARTLSKFLG-------------SQFLVKASMGHVRDLPKSELGVDLEN 47 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + + K + +K ++ +A ++ A DPDREG+ + + L Sbjct: 48 GFTP----------KYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLL 97 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + PE R +++ AV ++ R + + AR D L G ++ Sbjct: 98 GIPPETPC---RVEFHEITKNAVLNSLKSPRPID--LNRVNAQQARRVLDRLVGYGLSPL 152 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 + LS GRVQ+ L LVV R+EEIE F ++++++ ++TP +ER A Sbjct: 153 LWRKVKRG-----LSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLAR 207 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ ++ E V + + V + S++ PLPF+ S + Sbjct: 208 LAR------FKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQ 261 Query: 300 EAAKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EA +R G+ + + + Q+LYE LITY R+D + EE A + Sbjct: 262 EANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEH 321 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLI 406 + V D + R + DAH AI PT LT ++ K+Y LI Sbjct: 322 ------YGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLI 375 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 ++L A + E+++ F A R L G+ L +E + LP Sbjct: 376 WERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEE---EEEGKLPP 432 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G+ L ++ + T PP +T+ TL+ A+ G+G + Sbjct: 433 LREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEE-----------------KGVGRPS 475 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISE 583 T A IE + KRG++ + +Y+H T G+ + L E TA E L + E Sbjct: 476 TYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEE 535 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-----FRGIVAPGSGGSADKKKAAPRKRSA 638 Q + D ++ + Q + +A + F I P G KK + A Sbjct: 536 GQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLA 595 Query: 639 KKSPPADE 646 P + Sbjct: 596 CSGYPECQ 603 >UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9Z3_9FIRM Length = 707 Score = 541 bits (1394), Expect = e-152, Method: Composition-based stats. Identities = 195/672 (29%), Positives = 306/672 (45%), Gaps = 67/672 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR+IA V+ K +G+ + G G +V+WCIGHL+ A+ YD +Y +W Sbjct: 5 LVIAEKPSVARSIAAVIGA-TEKQNGYWQGG-GYLVSWCIGHLVSFAEAGQYDEKYCKWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 DLPI+P+ WQ +Q +++ L+ + + A D REG+L+ V Sbjct: 63 YEDLPILPQPWQFIVPDEKKQQFEIVRSLLNRPDVDSVTAATDAGREGELIFRFVYQMAG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R I+ + A+ LR +S++ L SAL RA+ADWL GIN TR + Sbjct: 123 CT----KPVKRLWISSMEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATRLF 178 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++L Y L+VGRVQTP L ++V RD +I F + ++ V Sbjct: 179 SVL-----YHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQ------------- 220 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + R+ A + + +G A+ S ++++E P + L+ LQ E Sbjct: 221 -----SGSLKADSERISDAEAANLLKEKCTGANAVCVSIRREKKTEQPPKLYDLTTLQRE 275 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A + FG +A+ LD Q+LYE KL+TYPR+D +YL E+ +++ + P Sbjct: 276 ANRLFGFTAKQTLDYAQQLYE-KKLLTYPRTDSQYLTEDMGRTAQHLVSDLLGLLP--FA 332 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA---INLTENEAKVYNLIARQYLMQFCPD 417 Q + R + KKV HHAIIPT+ L E+E K+ NL+ + L Sbjct: 333 QGLALTAEVGRVLNSKKVSDHHAIIPTSEFVKQGFTGLAESECKLMNLVCSKLLCAVAAP 392 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-------LGSKERDEENDGTPLPVVAKG 470 + A +F AK + + GW+ + L + +E LP + +G Sbjct: 393 HEYETVTAVFSCAGNEFAAKGKTVLVPGWKEIDQRFRSTLKTDGEEETETLNTLPELTEG 452 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA--RFVQDK--------DLKKILRATD 520 ++ E T PP+ +T+ TLLSAM +DK + Sbjct: 453 QNFSVTT-DISEHFTSPPKAYTEDTLLSAMERAGAEDMPEDKVNCSAGAREGGLGQAERK 511 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQ 580 GLGT ATRA I+E L + GF+ +KG+ + T G L LPE T P +TA WE+ LT+ Sbjct: 512 GLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPVLTAEWENRLTE 571 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQA------KRT--PVRQFRGIVAPGSGGSADKKKAA 632 I++ +FM + + QL+ K+ + P + Sbjct: 572 IAKGNADPDEFMAEIEAQVRQLVKTYSCISADKQNLFQSERVIIGKCPRCSENVY----E 627 Query: 633 PRKRSAKKSPPA 644 +K + Sbjct: 628 GKKNFYCGNRSC 639 >UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermedia K12 RepID=C7HY28_THIIN Length = 723 Score = 541 bits (1393), Expect = e-152, Method: Composition-based stats. Identities = 245/657 (37%), Positives = 356/657 (54%), Gaps = 32/657 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQV-VTWCIGHLLEQAQPDAYDSRYA 59 MRL IAEKPS+A+AIADV+ R+GDG+I+C + VTWC GHLLEQA+P+ Y + Sbjct: 1 MRLIIAEKPSVAQAIADVIGG-VRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDYVNG-G 58 Query: 60 RWNLADLPIVPEKWQLQPRPS-VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + + LP++P W+L PR KQ+ I+ L +A+E+V+AGD DREGQLLVDEVL + Sbjct: 59 KVLASHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAGDADREGQLLVDEVLLF 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L + + R ++ L+ ++V RA+ ++SN PL SALAR RADWL G+N + Sbjct: 119 LNW----KGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQRADWLMGMNASI 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A + + G QG SVGRVQTP L L+V R +I+NF +D ++V+A + A Sbjct: 175 ALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQATLDGD----IRA 230 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +WQ E + ++G LL + AE + GQ A V ++ K AP+P++LS LQ Sbjct: 231 LWQIPEDLQT---DDGLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPYALSTLQ 287 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A+ R GLSA++ L Q+LYE KL TYPRSDC +LP E A ++ A+ Sbjct: 288 KTASSRLGLSAKDTLAAAQELYEA-KLATYPRSDCPWLPVEMHAAAAQIIRALGA----- 341 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR--SSAINLTENEAKVYNLIARQYLMQFCP 416 +DP+ R+ W+ KV+AHH IIPT R + L+EN K+Y L+ YL F P Sbjct: 342 AEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGLAEVSGLSENAKKIYGLLRESYLRLFMP 401 Query: 417 DAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTL---LGSKERDEENDGTPLPVVAKGDE 472 F +F A AR + E+GW L S E DE LP++ +G + Sbjct: 402 PETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTEGQQ 461 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L CE +V+ ++T PP+ +TD TL++AMTG+ + V D LK L+ T GLGTEATRA +I Sbjct: 462 LACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMI 521 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQ 589 E+L R + +K + IH T+ G L L + P TA E L I+ + + Sbjct: 522 EVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARSTFD 581 Query: 590 DFMQPLVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 +FM + + + + + P GG ++ + + + Sbjct: 582 EFMTAQIDAVRESTQKLLGGQLGATPAILHACPACGGGRCAQRTSKAGATYHRCLDC 638 >UniRef50_D0UIR3 TraE-like protein n=1 Tax=Aggregatibacter actinomycetemcomitans D11S-1 RepID=D0UIR3_AGGAD Length = 760 Score = 540 bits (1391), Expect = e-152, Method: Composition-based stats. Identities = 218/665 (32%), Positives = 352/665 (52%), Gaps = 21/665 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKP LA+ IA+ + +RK G+ EC N VVT IGH+L Q P+ + +Y Sbjct: 1 MKLIIAEKPQLAQVIAEAIGIINRKT-GYFECNNNYVVTNAIGHILMQKMPEEINEQYKE 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L DLP+ L+ +P +Q V++ L +A +++AGDPD EGQLLVDE++++ Q Sbjct: 60 WRLEDLPLQVRPIPLKVKPQTAEQFKVVQGLLAQADTVINAGDPDDEGQLLVDEIIEFCQ 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + QR L+NDL ++ ++A+ + NS+++ + ALAR++AD+++G+N+TRAY Sbjct: 120 FKGVQ----QRLLVNDLKVESAKKALANIEPNSKYLGMRNKALARSQADYIFGLNLTRAY 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 TI R G + L VGRVQTP L LVVRR + + ++ V + F A Sbjct: 176 TIFARKKGIKNALMVGRVQTPTLALVVRRFLQNRDHKESYYYNVGGNFTF-NQTSFNAKL 234 Query: 241 QPSEAC--EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 +E +P ++E R++ +A + + +++ + ++ SAPLPFSL LQ Sbjct: 235 VLTENIPTDPNNEKEKRIIEEAVANGIKTACEAKNVTLSTVTIEDKTTSAPLPFSLLDLQ 294 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + ++G S+ VL I Q L E HK ITY RSDCRYL ++ F ++ ++ P+ Sbjct: 295 VRLNNKYGFSSDKVLKITQDLREKHKAITYNRSDCRYLTDDQFNEAPQTLDFLTDLFPE- 353 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIP-TARSSAINLTENEAKVYNLIARQYLMQFCPD 417 LP+ +D + R ++ KV AH AIIP T + + T++E KV+ IA QY +QF P+ Sbjct: 354 LPKEQIDKTKKGRAFNANKVTAHTAIIPVTGKYQLNDFTQDELKVFTEIATQYFIQFLPE 413 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG--TPLPVVAKGDELLC 475 +++ + +F A GW L+ + +EEN L + + + C Sbjct: 414 KSYQQVTAIVACNGYQFKTTATKTLNHGWSKLVADDDVEEENQSDFEQLASLTEQAQGQC 473 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------GLGTEAT 527 + E+ + +T+P +T+ATLL + I+++V+D D+KK+L D G+GT AT Sbjct: 474 NRIEIKKEKTKPLPIYTEATLLKDLQNISKYVKDPDIKKLLIDKDKGKDGENGGIGTPAT 533 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 R+ II+ L G++ +G+ I TD SLP++ T PDMTA W +I + Sbjct: 534 RSAIIKKLVDTGYIEYQGKKILPTDLAIDFIGSLPDIITYPDMTALWFEQQREIEQGNLS 593 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 F+ + + + I QA+ V + +G G +K + S P +V Sbjct: 594 VNSFLDRIEKFVMEQIKQAENLKV-ELKGEPCECGKGVLILRKTDKGTFFSCSSYPECKV 652 Query: 648 GSGAI 652 A+ Sbjct: 653 IKPAL 657 >UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B550_METEA Length = 888 Score = 539 bits (1388), Expect = e-151, Method: Composition-based stats. Identities = 242/645 (37%), Positives = 351/645 (54%), Gaps = 28/645 (4%) Query: 2 RLFIAEKPSLARAIADVL----PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 RLFIAEKP+L RAIA L G GFIE G G VTW IGH + A+P Y S Sbjct: 4 RLFIAEKPALGRAIATALATLSGARPSAGRGFIEVG-GDCVTWTIGHAYDTAEPGDYSST 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W+L LP++PE+W+L P + Q+ V+K + V+ GD +REGQL+VDE+L Sbjct: 63 WDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYDHFVNVGDAEREGQLIVDEILI 122 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + P + V R ++ + V A+ NS+ L +A+AR RADWL G+NM+ Sbjct: 123 ENGVDPFSPK-VSRVWVSSFVEKDVAAAVAGAFPNSQKKSLYEAAVARQRADWLLGMNMS 181 Query: 178 RAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 R + ++ + +G +G +SVGRVQTP L LVV RD +IENF A D F V F Sbjct: 182 RVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENFKAVDHFAPSITFVHENG-TF 240 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A WQ + D EGRLL + +A+ +V +I+G+ V SY++ +S S PLPF+LS Sbjct: 241 KAAWQFPADTKGL-DPEGRLLDKAVAQALVQKIAGKTGTVESYSETPKSTSPPLPFALST 299 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF-AGRHAVMNAISVHA 355 LQ +++FGL+AQ LD+ Q+LYE HK ITYPRSD ++LP ++ ++ Sbjct: 300 LQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPNSVHTDEADGILRNLAGVR 359 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL---TENEAKVYNLIARQYLM 412 +P +++ +DDKKV HH IIPT+ +SA L E E KV+ LIAR ++ Sbjct: 360 ELADAAGRANPKLKSPAFDDKKVTDHHGIIPTSEASASKLAAMGEIERKVFLLIARTFVA 419 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT-PLPVVAKGD 471 QF PD + + +F A + + GW+T+ G++E DEE + LP + D Sbjct: 420 QFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAEEADEEEEAEGTLPSMKMKD 479 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + G + ++T+PP HF D TL+ AM I +VQD++++K LR DG+GTEATRA + Sbjct: 480 PVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEVRKRLRENDGIGTEATRASM 539 Query: 532 IELLFKRGFLTK----KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 IE L + +L + K + + STDAG+ L LP PD TA WES L ++ + Sbjct: 540 IEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLPSDLVAPDTTAMWESFLERVKGGEFT 599 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQFRGI----------VAPGS 622 FM + + + A Q +G P Sbjct: 600 LAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGHGTECPHC 644 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 538 bits (1386), Expect = e-151, Method: Composition-based stats. Identities = 144/682 (21%), Positives = 254/682 (37%), Gaps = 90/682 (13%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L + E P+ A+ I L +G V GH+ + D + Sbjct: 6 MKLVVVESPAKAKTIEKYLG-------------SGYQVLASYGHIRDLPSKDGSVNPDNG 52 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 +++ Q P +L I+ + E+ ++ A DPDREG+ + +L+ L+ Sbjct: 53 FSMV----------WQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLK 102 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R N + AV A+ R L + LAR D+L G ++ Sbjct: 103 TKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDN--DLINAYLARRALDYLVGFTLSPIL 160 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 G S GRVQ+ L LVV R++EIE F ++++ V+A + + FT+ Sbjct: 161 WRKL-----PGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIG-FTSRL 214 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E+ + + AE + + V++ K S + PF+ S LQ E Sbjct: 215 IQWRGQKL---EKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQE 271 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 AA++ G +A + + + Q LYE LITY R+D + E A + + +P Sbjct: 272 AARKLGFAASHTMRLAQSLYE-EGLITYMRTDGVQMDESAIAAARKTI--TQRYDGGYVP 328 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 ++ + +AH AI PT S + + A++Y LI ++ L A Sbjct: 329 DKPRQYQVKAK----NAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKL 384 Query: 421 RKCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERDE------ENDGTPLPVVAKGDE 472 + ++L G+ + + +G+ TL D + LP++ GD Sbjct: 385 ERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDA 444 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 L ++ + TQPP +++A+L+ M + +G +T A +I Sbjct: 445 PLKKEVRADQHFTQPPPRYSEASLVKKMEDLG-----------------IGRPSTYASVI 487 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRYQ 589 ++L R ++T + ++AG+ L L D TA E L +IS + +Q Sbjct: 488 QVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQ 547 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------------------APGSG-GSADK 628 + + + P G Sbjct: 548 KVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLAL 607 Query: 629 KKAAPRKRSAKKSPPADEVGSG 650 K A + P + G Sbjct: 608 KGGRFGAFIACSNYPECKYTRG 629 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats. Identities = 147/688 (21%), Positives = 264/688 (38%), Gaps = 98/688 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ A+ I L K V GH+ + D Sbjct: 1 MNVVIVESPAKAKTINKYLGK-------------DYTVLASYGHVRDLPPKDGSV----- 42 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 LP K+L+ I + EA ++ A DPDREG+ + VL+ L+ Sbjct: 43 -----LPDDDFAMSWSVDSKSQKRLSEIASAVKEADRLILATDPDREGEAISWHVLEVLK 97 Query: 121 LAPEKRQQ-VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + ++R + N + ++ A+ R E PL + LAR D+L G ++ Sbjct: 98 KKRVLKDKKIERVVFNAITKSSILEAMKNPRELDE--PLVDAYLARRALDYLVGFTLSPV 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 G S GRVQ+ L LV +R+ EIE F +++++ + A++ TP + A Sbjct: 156 LWRKL-----PGARSAGRVQSVALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + + + A + + G V++ K + + PF+ S LQ Sbjct: 211 LTGFDGQKI---TRLDIKNEQEATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G +A + + QKLY ET LITY R+D + +E V+ S Sbjct: 268 EASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVI--AS 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + +P+ + + +AH AI PT + L E+ A++Y LI Sbjct: 326 RYGDEYVPEKPRMYSSKAK----NAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGS-KERDEENDGT 462 ++ + AV + +++D G A + G+ TL K+ +E+ + Sbjct: 382 KRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESK 441 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + +GD L + E + T+PP FT+ATL+ M + + Sbjct: 442 RLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A ++ L RG++ + + D G+ + L + D TA E L Sbjct: 485 GRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI--------------------VA 619 +IS ++ ++ +++ D+ + + Sbjct: 545 KISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGSDPRKC 604 Query: 620 PGS-GGSADKKKAAPRKRSAKKSPPADE 646 P G K + + D+ Sbjct: 605 PKCDTGRLSLKVSRFGAFVGCSNYNKDK 632 >UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacterium spiritivorum ATCC 33861 RepID=C5PM09_9SPHI Length = 704 Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats. Identities = 187/676 (27%), Positives = 328/676 (48%), Gaps = 54/676 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR +A V+ DG+I GNG T+ GHL++ P AY + Sbjct: 1 MKVVIAEKPSVARDLARVMGAKEV-NDGYI-SGNGYAFTYAFGHLVQLCTPQAYG--FHT 56 Query: 61 WNLADLPIVPEKWQLQPRPSVT-----------KQLNVIKRFLHEASEIVHAGDPDREGQ 109 W++++LPI+P +++L+ + KQLN IK L +A E++ A D REG+ Sbjct: 57 WSVSNLPIIPAQFKLESKKVKKDGKQMDDGGALKQLNTIKGLLDKAEEVIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL +R I+ +A++ L+ SE+ L +SA +R+ +D Sbjct: 117 LIFRNIYYYLG----ANVPFKRLWISSQTDKAIKEGFANLKEGSEYDSLYMSARSRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ AG +G+LS+GRVQTP L ++ R E +NF F++++A Sbjct: 173 WLIGINATQAITLA---AGNRGLLSLGRVQTPTLAMICSRFIENKNFKPTAFYKIQAQFE 229 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESA 288 ++ R+ + LAE + +I+ G A VT K E Sbjct: 230 KENI--------------KFKATSNRIDQKDLAEETLAKITVGASAKVTKVEGKEVKEPP 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ +A K++G SA L I Q LYE K+ITYPR+ RY+ E+ F + Sbjct: 276 PLLYDLTNLQQDANKKYGYSADQTLSIAQTLYE-KKVITYPRTGSRYIGEDVFEKIEELF 334 Query: 349 NAISVHAPD---LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNL 405 ++ A + + + ++ + R DDKKV HHA++ T + L + ++ +YN+ Sbjct: 335 QHLADTAEEGIATISRNLIGAKLNKRSVDDKKVTDHHALLVTDEKPSAML-KEQSNIYNM 393 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN------ 459 IA++ + F + + +D + +AK + + GWR E+ E++ Sbjct: 394 IAKRMVESFSDVCLKDITTVIMDAEGVELIAKGTVIKQYGWRLSADQLEQPEDDKKDNDD 453 Query: 460 ---DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 + LP ++ + L +++E+ T+ T+A+LL AM + + D ++++ + Sbjct: 454 ADTENAQLPKLSAEELLEILALDLMEKFTKAKPVHTEASLLKAMETSGKEIDDDEMRQAM 513 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWE 575 + GLGT ATRA IE LF+R ++ + + + TD G A+++ + + + ++T WE Sbjct: 514 KDC-GLGTPATRAATIETLFQRDYIRRDKKKLIPTDKGLAVYNLVKDRAIAKVELTGKWE 572 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSG-GSADKKKAAPR 634 L ++ + Y FM+ + ++ + + + + + P K Sbjct: 573 QKLEEMRANKVSYDVFMKHIKDFTVRITKELLQLRISLTQDVEPPKQTVSIKCPKCDKGS 632 Query: 635 KRSAKKSPPADEVGSG 650 +K D G Sbjct: 633 MILYEKVAQCDHYARG 648 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 537 bits (1383), Expect = e-151, Method: Composition-based stats. Identities = 141/671 (21%), Positives = 253/671 (37%), Gaps = 88/671 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A++I +L G V GH+ + + + A + Sbjct: 6 LIVVESPAKAKSIQKMLGA-------------GYEVRASKGHIADLPEHELGVDTQADFA 52 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q + + +KR ++ A DPDREG+ + V L L Sbjct: 53 P----------QYTVKKDKQPIVEELKRAARG-KRVLIATDPDREGEAIGWHVARLLGLN 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P+ R +++ P+ V A+ + R + L + AR D L G ++ ++ Sbjct: 102 PQTPL---RVEFHEITPKVVRAAVQKPRPIDQ--SLVDAQQARRVLDRLVGYQLSPVLSM 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R + LS GRVQ+ L L+V R++EIE FV ++ + ++ + + F A+ Sbjct: 157 EFR----RRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQ-FKAMLYS 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESAPLPFSLSALQIEA 301 + ++ + A+ + + S + +AP PF S LQ A Sbjct: 212 LGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAA 271 Query: 302 AKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + R G +A + + QKLYE T LITY R+D + +E A A + Sbjct: 272 SSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPR--HF 329 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P LP+ + DAH AI PT+ + L++ E ++Y LI ++ Sbjct: 330 GPAYLPEKPNFFAGKKAA---NAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQR 386 Query: 410 YLMQFCPDAVFRKCVIELDI------AKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 ++ AVF + + + F A L G+ + G +E DE Sbjct: 387 FVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDE--AENR 444 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + + + T+PP +TDA+L+ + + +G Sbjct: 445 LPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMG-----------------IG 487 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQ 580 +T A I+ L +RG+L + G+ + T G+ + L + D TA ES L + Sbjct: 488 RPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDE 547 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 I E + + ++ + + + + P G + K + + Sbjct: 548 IEEGKAAWPKVVREFYEPFLKDFAKVPQK--------LCPKCGRPLELKVSRFGQFLGCT 599 Query: 641 SPPADEVGSGA 651 P + Sbjct: 600 GYPECKHTERL 610 >UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C0FPK2_9FIRM Length = 680 Score = 537 bits (1383), Expect = e-151, Method: Composition-based stats. Identities = 200/651 (30%), Positives = 302/651 (46%), Gaps = 64/651 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL IAEKPS+A++IA VL R DG++E G G +V+WC GHL E A Y++ A+ Sbjct: 1 MRLVIAEKPSVAQSIAAVLGAKSR-HDGYLEGG-GYIVSWCFGHLAELADAAVYNAVDAK 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDY 118 W LA LPI+P ++ R KQ ++++ + E+V+A D REG+L+ V Sbjct: 59 WTLAALPIIPTSFRFIVRSEKQKQFDILRELVRREDVAEVVNACDAGREGELIFRTVYCL 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + + R I+ + A+ +LRS ++ L SAL RA+ADWL GIN TR Sbjct: 119 AGCS----KPILRLWISSMEDDAIRSGFQQLRSGRDYDGLHQSALCRAKADWLVGINATR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 ++++ Y L++GRV +P L L+V+R+ EI FVA+ F+ V+ Sbjct: 175 YFSLM-----YGRTLNIGRVMSPTLALLVQREAEISAFVAEPFYTVQLDC---------- 219 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + R+ R A+ + N G+ V S K +SE AP + L++LQ Sbjct: 220 ---------GFPATTDRMKDRKDADAIANACKGKTVTVKSVERKEKSEKAPALYDLTSLQ 270 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 +A + G ++Q LD Q LYE KL TYPR+D YL ++ ++ A + Sbjct: 271 RDANRVLGYTSQQTLDYLQALYE-KKLCTYPRTDSHYLTDDMEGSVPGLVAAAAAACGVE 329 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT---ARSSAINLTENEAKVYNLIARQYLMQFC 415 P + + KKV HHAI+PT + +L E +V L A+ L Sbjct: 330 KPPTICA----KQVCSSKKVTDHHAIVPTISAEKVDMASLPLGEREVLKLAAKGLLRAVD 385 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 + + VI +D A F AK + + GW+ E+++ LPV + L Sbjct: 386 EPHRYAETVITVDCAGQSFTAKGKTVLAPGWKRY----EQEQTEAVPALPVATENQTLSV 441 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARF--VQDKDLKKILRATDGLGTEATRAGIIE 533 V +T PP+HFT+ TLL+AM + D + K G+GT ATR+GIIE Sbjct: 442 SAASVKTGKTTPPKHFTEDTLLAAMENAGKEDMPDDAERK-------GIGTPATRSGIIE 494 Query: 534 LLFKRGFLTKKGRY----IHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQ 589 L GF+ ++ + T G AL LPE P +TA WE L +I + Sbjct: 495 KLVSSGFVERRKSKKITNLLPTSTGTALITVLPEQLQSPQLTAEWEHRLKEIERGEIAPD 554 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFR-------GIVAPGSGGSADKKKAAP 633 FM + L +L+ K P + P G + + Sbjct: 555 SFMDGIAAMLNELVQTYKPIPGAEVLFPSGREVVGKCPRCGAEVTESQKGF 605 >UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=C9LSJ2_9FIRM Length = 836 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 124/672 (18%), Positives = 248/672 (36%), Gaps = 88/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A+ I L K +V +GHL + + + Sbjct: 118 LVVVESPAKAKTIEKYLGKK-------------YMVRASMGHLRDLPKSQFGIDVENDFA 164 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +K+ A+++ A DPDREG+ + + L + Sbjct: 165 P----------KYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGID 214 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P + R + N++ A++ A+ + + + AR D + G ++ Sbjct: 215 PNENC---RIVFNEITKPAIQAAVKEPYPIN--LDRVDAQQARRMLDRIVGYKLSPLLWR 269 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + L+ R++EI+ FV ++++ V + +F A Sbjct: 270 KIKKG-----LSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELAT 324 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ L + +V ++ Q V + + PF+ S++Q +A+ Sbjct: 325 VDG------KKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDAS 378 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G +++ + I Q+LYE LITY R+D L + + Sbjct: 379 RKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGT--SF 436 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP+ K DAH AI PT+ + L+ + ++Y LI ++ Sbjct: 437 GADYLPEK-----PNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQR 491 Query: 410 YLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 ++ AVF + + + A L G+ + +++ LP +A Sbjct: 492 FVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVY---ADNKKEKDVLLPELA 548 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 G+ L + T+PP + +A+L+ + + +G +T Sbjct: 549 AGEALSLLDLLPEQHFTEPPPRYNEASLVKTLEE-----------------EDIGRPSTY 591 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A IIE + RG++ ++ ++ TD G + L E TA E+ L +I+E + Sbjct: 592 APIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGK 651 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV-----RQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 D ++ + +++A + ++ G + K+ K A Sbjct: 652 VDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACP 711 Query: 641 SPPADEVGSGAI 652 P + Sbjct: 712 GFPDCRNTKPLL 723 >UniRef50_Q48AZ8 DNA topoisomerase III n=10 Tax=Bacteria RepID=Q48AZ8_PSE14 Length = 721 Score = 536 bits (1381), Expect = e-151, Method: Composition-based stats. Identities = 224/663 (33%), Positives = 330/663 (49%), Gaps = 34/663 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MR+FIAEKP+L + IA+ L + DG+ ECG+ +VTWC+GHLL A P+ ++ Y Sbjct: 1 MRVFIAEKPALGQVIAEALG-TVIRKDGYFECGSNNIVTWCVGHLLALAPPEVHNPAYKD 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W ADLP+ QP QL V+++ + ASEIVHAGDPD EGQLLV+EVL+Y Sbjct: 60 WVQADLPLKLRPAMYQPIARTRDQLKVVQQLIGRASEIVHAGDPDDEGQLLVEEVLEYFG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R LIND+N A +A++ LR N EF L ALAR+ D LYG NMTRA Sbjct: 120 ----NTAPVKRILINDMNANAARKALEGLRDNREFYGLYQKALARSIGDQLYGFNMTRAC 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ GR G + VLSVGRVQTP+LGL+V R ++ + ++ V A + A Sbjct: 176 TLAGRAKGVKSVLSVGRVQTPILGLIVNRYLANKSHASTFYYSVAASLAVGGH---RAQA 232 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + A + D++ R++ A +V + +PA V + + APLPF+L LQ+ Sbjct: 233 RLVVATDAPLDDKNRIIDEVYATNVADACRQKPAAVIEARVEEKQTPAPLPFALLDLQVY 292 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 +K + A+ L + Q L E +K ITY RSDC YL E F ++ +S PDL Sbjct: 293 MSKTHSIDAEKTLALTQALREKYKAITYNRSDCSYLTAEQFGEAPQTLSLLSEALPDLAG 352 Query: 361 QPV-VDPDIRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 V+ + ++R +DD KV AH AIIPT + L+ +E VY I ++Y+ QF P+ Sbjct: 353 MFTEVNSERKSRAFDDSKVSAHTAIIPTAVKIDITQLSADERAVYMAIVKRYVAQFLPEK 412 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRT-LLGSKERDEENDGT--------PLPVVAK 469 + + + FVA++ + GW + E DE+ L + Sbjct: 413 RYLSAEVRFGVNGHTFVARSTKVTHPGWTAQVTEENEPDEDGSDAAEVASPFDALAGLKV 472 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 GD +C+ V + +T+P +T+A LL + +A++V+D +K++L D G Sbjct: 473 GDAGVCDGITVAKEKTKPLPLYTEAELLKDLRRVAKYVKDPRIKQLLIDRDQGKKGENGG 532 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI 581 +GT ATR ++ L +RGF + + + T G +LP +AT PDMTA W I Sbjct: 533 IGTPATRGAVLAKLQERGFYAVEKKKLIPTALGLEFIAALPAIATTPDMTALWHEQQQMI 592 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQA-------KRTPVRQFRGIVAPGSGGSADKKKAAPR 634 + F+ L + + PV P G Sbjct: 593 EAGELTVDAFLDELEAFIADQVQNIDLGNVQGDGKPVLDSLNAQCPMCGSDLAVTPRVVG 652 Query: 635 KRS 637 R+ Sbjct: 653 CRA 655 >UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8_9BACE Length = 711 Score = 536 bits (1381), Expect = e-150, Method: Composition-based stats. Identities = 190/669 (28%), Positives = 310/669 (46%), Gaps = 57/669 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKPS+AR IA + RK +G+ GNG VTW +GHL++ A PD Y + Sbjct: 1 MITILAEKPSVAREIARITGA-TRKEEGYY-TGNGYHVTWALGHLVQPALPDGYG--FKG 56 Query: 61 WNLADLPIVPEKWQLQPRPSV-----------TKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + LP++PE++ L PR KQ+ VI + E+ I+ A D REG+ Sbjct: 57 FRRDSLPVIPEEFMLIPRQVKTDKGYKADAAAVKQIKVITKLWQESEGIIVATDCAREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + Y +R I+ L A+ + + L+ E+ L ++A AR+ AD Sbjct: 117 LIFRYLYAYTGCT----LPFRRLWISSLTDTAIRKGLKELKDGHEYDDLYLAAKARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A T+ Y SVGRVQTP L +V +R E F + ++ + Sbjct: 173 WLVGINGTQALTVAAGRGTY----SVGRVQTPTLAMVCKRYRENRRFTPEPVHQLHFSVP 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 + + + A + N++ + A VT K + E+ Sbjct: 229 SAN-----------AGTVVKFASVKKWQDKNEAAILYNKVKAKMCATVTKVEKKEKVENP 277 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA + G +A+ L++ QKLYE KL+TYPR+ R++PE+ FA + Sbjct: 278 PLLYDLTTLQKEANTKHGFTAEQTLELVQKLYEA-KLVTYPRTSSRHIPEDVFAEIPLLF 336 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 ++ H L + V + R D KV HHA++ T L +NE +Y++IA Sbjct: 337 ERLAGH-STLSDKIVNLDGLNRRSVDASKVTDHHALLVTPNRPLA-LYKNEQIIYDMIAG 394 Query: 409 QYLMQFCPDAVFRKCVIELD--------IAKGKFVAKARFLAEAGWRTLLGSKERDEEND 460 + + F + V + + F AK + +AGWR + G E E+N Sbjct: 395 RMVEAFSEECVKDTATVVAEVVPDAGERCEGLTFEAKGCIVRKAGWRGVYG--EYGEDNG 452 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF-VQDKDLKKILRAT 519 T LP +GD L+ + T+P T+++LL+AM R V+D++ ++ L+ Sbjct: 453 NTALPDWTEGDTLVMAGCSMSSGMTRPKPLHTESSLLAAMETAGRDDVEDEEARQALKDC 512 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVL 578 G+GT ATRA IIE L +R ++ + + + T+ G AL+ + +M +MT WE+ L Sbjct: 513 -GIGTPATRAAIIETLIRREYMVRVKKSLVPTEKGLALYSIVKDMDIANVEMTGRWEAEL 571 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQA---KRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 +I + + ++ FM+ + ++ R + G P G + + Sbjct: 572 AEIEKGKTPHEAFMRDIESYTRKITTDLLACDRIFGHKASGCTCPKCGKGTMQFYGKVVR 631 Query: 636 RSAKKSPPA 644 +P Sbjct: 632 ---CDNPDC 637 >UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LWM4_9FIRM Length = 714 Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats. Identities = 214/659 (32%), Positives = 343/659 (52%), Gaps = 33/659 (5%) Query: 3 LFIAEKPSLARAIADVL--PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 ++IAEKP + RA+A L KG G G+ VTW GH+L A P+ Y Y Sbjct: 7 VYIAEKPDIGRAVAAYLWPDGGMEKGKGCFRKGDIA-VTWAFGHILGMATPELYGEEYKV 65 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W+ + PI+P W ++P P +QL++IK + +A +VHAGDPDREGQLL+DE+LD+L Sbjct: 66 WS--NYPILPSTWLMKPDPQKKEQLDIIKGLIKDADVVVHAGDPDREGQLLIDEILDFLH 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +V+R LIN + ++++RA LR N +F L + L RARADWL G+N++RAY Sbjct: 124 ----YKGEVRRILINAKDDESLKRAFASLRDNKDFYGLYEAGLGRARADWLIGMNLSRAY 179 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 T+ R AG+ G +GRV+ P L LVV+R+++I +F K ++ ++ FTA Sbjct: 180 TVNARKAGHDGTYRIGRVKVPTLALVVQREKDILSFKPKKYYVLQGIFAYKG-VPFTATL 238 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 +PSE DEEGR+L L + + ++ ++ + PLP+SL LQIE Sbjct: 239 EPSENIPL--DEEGRVLDVNLLQAIKLKVEKAEGVIRDVATSEGKQYPPLPYSLDTLQIE 296 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP 360 A K +G S Q VL+ QKLYE KL++YPRSDC Y+P ++ A+ D+ Sbjct: 297 ANKIWGYSPQEVLETVQKLYE-RKLVSYPRSDCNYIPASQREDVPRILAALKEM--DVQG 353 Query: 361 QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVF 420 + DI ++ ++D K+ AHHAIIPT ++ E E ++Y +I+++Y++QF P F Sbjct: 354 AAGANVDIESKAFNDGKITAHHAIIPTGIRPE-DMNEQEERIYGMISKRYIIQFYPPHEF 412 Query: 421 RKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV 480 K L + F + + + G+R +E +E+ LP A GD++ + Sbjct: 413 EKTTFSLQVGDEMFSGSGKIIRKMGFRE--VEREEEEQEGTPRLPDFAVGDKIAKGDYSI 470 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQ-DKDLKKILRATDGLGTEATRAGIIELLFKRG 539 + ++T+PP+ FT+ TL++AMT I +F++ D ++ ++ G+GT ATR II L Sbjct: 471 LNKKTKPPKRFTEGTLIAAMTNIWKFMKADNPNREKMKEVKGIGTPATRDTIIAELQATS 530 Query: 540 F--------LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 L K + + T G +L ++ PD TA E L +I+ + D+ Sbjct: 531 LKGKAVEPCLKKVKKELLPTPFGISLIENVSPSLAVPDTTAEMEYALDEIAHGKGNLSDY 590 Query: 592 MQPLVGTLYQLIDQAKRTPV---RQFRGIVAPGSGGSADKKK---AAPRKRSAKKSPPA 644 M + +++ I A++ + + P +K + + Sbjct: 591 MDDVYSMVHENIQFAEKHLFPLPKDKKRTPCPICREGILLRKYSQKSKMYFHMCSNEKC 649 >UniRef50_C0QH35 DNA topoisomerase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QH35_DESAH Length = 855 Score = 535 bits (1379), Expect = e-150, Method: Composition-based stats. Identities = 187/654 (28%), Positives = 322/654 (49%), Gaps = 42/654 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + EK S+A A L ++K DG+ E G+ V+TW +GHL+E +PD YD+ +W Sbjct: 4 LILTEKFSVASDFAKALGVKNKK-DGYFE-GDAHVITWAVGHLVELFEPDDYDAGLKKWR 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + LP++PE+++ +P +Q IK L + I+ A D REG+++ +L Sbjct: 62 VETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTILLESG 121 Query: 121 LAPEKRQQVQRCLIN-DLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 ++++ R + L P+ V +++L+ +++ L + R +DWL G+N+TR Sbjct: 122 FRD--KERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRL 179 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ + SVGRVQT VL ++V R E E+F+ + ++ K R+T Sbjct: 180 MTVRL-----GDLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKVLFSGDKG-RWTGR 233 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESESAPLPFSLSAL 297 W ++++E R+ +P A+ ++ R + P +V S + + E PL FSL+ L Sbjct: 234 W--------FKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTDL 285 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA RFG A+ L I Q LY+ K ++YPR+D + L + V+ + PD Sbjct: 286 QQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACPD 345 Query: 358 LLP--QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 L P R ++D K+ HHA+IP S + +E +++L+ R++ F Sbjct: 346 LFAFVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEAA-SRDEKLLFDLVVRRFAAAFH 404 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 PD F + AK F + + + + GW+ + G+ RD + + +P + +GDE Sbjct: 405 PDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRD-KAEAEIIPPLVEGDEGAV 463 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EK E E+QT PP ++D+ LL MT R+V ++++K++ R G+GT++TRA IIE L Sbjct: 464 EKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQIIETL 523 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPE-----MATRPDMTAHWESVLTQISEKQCRYQD 590 RG++ + G+ + +TD G L L + + T P+ TA WE L I+ + Sbjct: 524 ISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGSDIR 583 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFR----------GIVAPGSGGSADKKKAAPR 634 F+ + + + + K + + P G + + A Sbjct: 584 FLDHIKAFVTNAVAELKSAGLNVKLFKAEQPQAAVIGICPACGKAVRENPKAFS 637 >UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C9LK04_9BACT Length = 705 Score = 535 bits (1378), Expect = e-150, Method: Composition-based stats. Identities = 192/672 (28%), Positives = 296/672 (44%), Gaps = 70/672 (10%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIEC---------GNGQVVTWCIGHLLEQAQPDAY 54 IAEKPS+AR IA ++ K +G++ G+ VVTW +GHL+ A P+AY Sbjct: 5 IIAEKPSVARDIARIVGA-SNKQEGYLASTPSADFQLEGSDYVVTWAMGHLIALAMPEAY 63 Query: 55 DSRYARWNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGD 103 ++ + DLPI P +QL R P+ KQL VI+ +A I+ A D Sbjct: 64 G--FSAYKREDLPIRPNPFQLVVRQVRKDKEYHDDPAALKQLKVIRSCFDKADRIIVATD 121 Query: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 REG+L+ + +L + +R I+ L +A+ + L+ S + L SA Sbjct: 122 AGREGELIFRYIYQHLNCC----KPFERLWISSLTDKAIREGLSNLKPGSSYDNLYYSAK 177 Query: 164 ARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 AR+ ADWL GIN +RA +I R GY S+GRVQTP L +V RR +F + +++ Sbjct: 178 ARSEADWLVGINASRALSIA-RKGGY----SLGRVQTPTLAMVCRRYIANRDFSSVPYWK 232 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDK 282 + E A+ + + Q V S K Sbjct: 233 LSV-------------HTEKEGLSLKAIGSEDYESEASAQTALATLRSQSRLTVESVARK 279 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PL + L+ALQ +A +R G SA L I Q LYE K+ TYPR+ RY+ E+ F Sbjct: 280 VTHTAPPLLYDLTALQKDANRRHGFSADKTLSIAQSLYE-KKITTYPRTGSRYISEDVFE 338 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 A++ I + + D+ KV HHAIIPT L+ +EA + Sbjct: 339 EVPALLRKIG---------KTLSNPLNIHSVDNAKVTDHHAIIPTGEMP-TGLSTDEANI 388 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL---------LGSK 453 YN++ ++ F PD+ + + F KA GW+ + K Sbjct: 389 YNMVVTRFAEAFSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQKELVTDAEKKEK 448 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 E D+E LP + +G+ L E+ +T+P +T+ATLLSAM + V++ D + Sbjct: 449 ENDDELVLPSLPDLTEGEVLSLVSAEITAHKTKPKPLYTEATLLSAMENAGKEVKEDDKR 508 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTA 572 K + G+GT ATRA IIE L R ++ + + I T+ G A++ + + +MT Sbjct: 509 KAMAEC-GIGTPATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKDKKIANAEMTG 567 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSADKKK 630 WE L I + + F Q + + + ++ Q V P G + Sbjct: 568 SWELALAAIEAGKMPSERFAQGINSYVGTICEELLSLSSEQKSYPVYRCPKCGQQSVGIY 627 Query: 631 AAPRKRSAKKSP 642 A K + Sbjct: 628 AKVAKCRHETCG 639 >UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein n=2 Tax=Pedobacter RepID=C6XWV5_PEDHD Length = 608 Score = 535 bits (1378), Expect = e-150, Method: Composition-based stats. Identities = 187/626 (29%), Positives = 321/626 (51%), Gaps = 49/626 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+ R +A V +K DG+IE G G TW GHLL+ A P Y + Sbjct: 1 MKIVIAEKPSVGRELAKVFGATTKK-DGYIE-GKGYSFTWAFGHLLQLAPPQEYG--FIG 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 W LP++P+K++L R P V KQL++IK+ EA+EI+ A D REG+ Sbjct: 57 WRRQHLPMLPKKFKLAIRKIKTKDGMVEDPGVRKQLDIIKKLFDEATEIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L+ ++ +R I+ +A++ L+ +++ L SA R+ +D Sbjct: 117 LIFRYIYYFLKC----KKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSESD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N T+A +I +AG + VLS+GRVQTP L ++ R EI+NFV + ++++ + Sbjct: 173 WLVGMNATQALSI---SAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQL- 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG------QPAIVTSYNDKR 283 + F A+ + AE ++ +I + S K Sbjct: 229 DKDGQLFRAM------------SVSNFDKKEEAEELLAKIEDVASGFSNGGKILSVEAKP 276 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 E PL LS+LQ EA KR G +A L + Q LYE+ KL+TYPR+ RY+ ++ FAG Sbjct: 277 RKEPPPLLHDLSSLQQEANKRKGFTADQTLSLLQGLYES-KLVTYPRTGSRYIGDDIFAG 335 Query: 344 RHAVMNAISVH-APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 A+++ + H + ++ + R + KKV HHAI+PT S L ++ V Sbjct: 336 VPALIDKVRGHKDFGKQAEFLLTVPLNKRSVNAKKVTDHHAILPTGESPY-QLNGDKQAV 394 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 Y+++ + + F + V I ++ F+A + AGWR++ + +++++ Sbjct: 395 YDMVVGRMIEAFHQECVKEITKISVESGS-LFIANGTVIRAAGWRSVFNESDEEKKDEDN 453 Query: 463 P-LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 P LP + KG+EL ++E+QT+P + +A+LL A+ + ++D++L+ ++ + G Sbjct: 454 PALPKLKKGEELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDS-G 512 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHWESVLTQ 580 LGT ATRA IIE L R +++++ R + T G A++ + + + ++T WE L + Sbjct: 513 LGTPATRAAIIETLISREYVSREKRNLVPTTKGLAVYDVVKDQKIAQAELTGQWEKRLEE 572 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQA 606 I DF + + ++ Sbjct: 573 IRSG-ASVSDFKAEIADYTKTITNEL 597 >UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP1_BACHD Length = 690 Score = 534 bits (1375), Expect = e-150, Method: Composition-based stats. Identities = 128/672 (19%), Positives = 246/672 (36%), Gaps = 86/672 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K V +GH+ + + ++ Sbjct: 5 LVIVESPAKAKTIGKYLGKK-------------YTVKASMGHVRDLPKSQMGVDIEDEYS 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + L +K + + A DPDREG+ + + L + Sbjct: 52 P----------RYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDID 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R + N++ QA++ A R + + L + AR D L G N++ Sbjct: 102 ETSEC---RVVFNEITKQAIKDAFKSPRPIN--MDLVDAQQARRVLDRLVGYNISPLLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + +++ R++EI+ F ++++ ++ E F A + Sbjct: 157 KVKKG-----LSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALDG-EPFEAKFYG 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ L +V+ ++ G V S K + PF+ S+LQ EAA Sbjct: 211 TNG------KKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + A + + Sbjct: 265 RKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIES---- 320 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + + D K DAH AI PT+ L+ ++ ++Y LI + Sbjct: 321 ---KFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWER 377 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVA 468 + A+ ++L F A + G+ + + ++ + LP + Sbjct: 378 LVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQ 437 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G + E+ E + TQPP +T+A L+ M + +G +T Sbjct: 438 EGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELG-----------------IGRPSTY 480 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A ++ + KRG++ R T+ G+ + + E + TA E L I E + Sbjct: 481 APTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEGK 540 Query: 586 CRYQDFMQPLVGTLYQLI----DQAKRTPVR-QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + + + ++ K ++ + G + G K K A Sbjct: 541 QQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMACS 600 Query: 641 SPPADEVGSGAI 652 + P + Sbjct: 601 NFPDCRNTKPIV 612 >UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID=B2RGV8_PORG3 Length = 709 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 195/674 (28%), Positives = 326/674 (48%), Gaps = 61/674 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS+AR IA V+ + K +G+IE G G VTW +GHL+ A P+ Y Sbjct: 1 MKVIIAEKPSVAREIARVV-RATNKKNGYIEGG-GYAVTWALGHLITAAMPEVYG--IKG 56 Query: 61 WNLADLPIVPEKWQLQPR-----------PSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 ++ +LPI+P + L PR PS QL VI++ A I+ A D REG+ Sbjct: 57 FHKENLPILPPVFTLIPRQVRSGKGYKADPSAVAQLKVIEKLFKAAEGIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL +A + +R I+ L +A++ + RL++ + + L +A AR+ AD Sbjct: 117 LVFRFIYEYLGIA----KPFERLWISSLTDKAIKEGLARLQNGAAYDNLYYAARARSEAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN T+A +I Y S+GRVQTP L +V R E + F + F+++ + Sbjct: 173 WLVGINATQAISIAAGRGTY----SLGRVQTPTLCMVCSRFLEHKKFEPQPFWQLSLAVK 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESA 288 DE F R + A + +++ P A V + K + Sbjct: 229 -EGDESFR------------FSSADRWFDKTEATALYDKLKQAPYATVETIVRKEARQEP 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ LQ EA RFG SA+ L + Q+LYE ITYPR+ RY+PE+ FA A++ Sbjct: 276 PLLYDLTTLQKEANSRFGYSAEQTLSLAQRLYE-KAYITYPRTGSRYVPEDVFAEIPAMI 334 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 + H P ++ D KKV HHA++ T + I++ +EA +Y++IA Sbjct: 335 AFLHDH-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP-IDVFGDEAVIYDMIAG 392 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--------- 459 + L F V + + KF+ K + E GWR++L + + ++ Sbjct: 393 RMLEAFSARCVKDISTVTAVCEEVKFILKGEIIKEEGWRSILKNSRKKDKEQAEAEERES 452 Query: 460 ----DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 +G +P +G +L + + T+P T+++LL+AM + ++D++L+ Sbjct: 453 RENGEGIIIPQWEEGGQLPLCACSLAQGTTKPKPLHTESSLLAAMETAGKELEDEELRAQ 512 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM-ATRPDMTAHW 574 + G+GT ATRA IIE LF R ++ ++ + + T+ G A++ + EM +MT W Sbjct: 513 FKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVREMKIGNAEMTGQW 571 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV---RQFRGIVAPGSGGSADKKKA 631 E+ L +I + + +DF + + Q+ D+ + + ++ I P G Sbjct: 572 EADLAKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSDIHCPKCGKGTLV--- 628 Query: 632 APRKRSAKKSPPAD 645 + + P Sbjct: 629 FYPRCAKCSDPNCG 642 >UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID=A0LDV2_MAGSM Length = 783 Score = 533 bits (1373), Expect = e-150, Method: Composition-based stats. Identities = 134/690 (19%), Positives = 255/690 (36%), Gaps = 94/690 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + I E P+ A+ I L + G V GH+ + + + Sbjct: 4 VVIVESPAKAKTINKFLGR-------------GYKVVATYGHIRDLPSKNGSVDTEHGFA 50 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + TK+++ + + + A +++ A DPDREG+ + V + L Sbjct: 51 M----------KYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHVYEVLNEK 100 Query: 123 PE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + QV+R + +++ A++ A+ R + + + AR D+L G N++ Sbjct: 101 KLLENVQVKRVVFHEITKTAIQDAVAHARDVD--MDMVNAQQARRALDYLVGFNLSPLLW 158 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L LV R+ EI+ F A++++ + A A Sbjct: 159 RKVRRG-----LSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEA 213 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + + + A+ ++ + +P V+ K+ + PF S LQ EA Sbjct: 214 RLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQEA 273 Query: 302 AKRFGLSAQNVLDICQKLY------------ETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 +++ G SA+ + + Q+LY ET LI+Y R+D L E + Sbjct: 274 SRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQIE 333 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYN 404 + + LP+ + + +AH AI PT L +++ ++Y Sbjct: 334 I--RYGKEYLPKS----PRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYE 387 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAK------GKFVAKARFLAEAGWRTLLGSKERD-- 456 LI ++ + A K L + +F A +A AG+ + + + Sbjct: 388 LIWKRTVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVS 447 Query: 457 -------EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQD 509 ++++ + LP + G +L + + + T+PP +T+ATL+ + Sbjct: 448 AQDREDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLE-------- 499 Query: 510 KDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---T 566 + G+G +T A + L RG++ R + D G + L + Sbjct: 500 ---------SYGIGRPSTYAPTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYV 550 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI-----DQAKRTPVRQFRGIVAPG 621 + TA+ E L +S + + M+ Q I +K + P Sbjct: 551 DYNFTANLEDQLDAVSRGEKSWVPLMEDFWQPFIQQITLKDETTSKEEVTTEQIDEPCPK 610 Query: 622 SGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 G K K A P + Sbjct: 611 CGAPLSIKLGRFGKFKACTGYPECKHTEPL 640 >UniRef50_Q04HI0 DNA topoisomerase n=48 Tax=Bacilli RepID=Q04HI0_OENOB Length = 722 Score = 533 bits (1372), Expect = e-149, Method: Composition-based stats. Identities = 196/673 (29%), Positives = 324/673 (48%), Gaps = 47/673 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECG-----NGQVVTWCIGHLLEQAQPDAYDSR 57 + +AEKPS AR+ + L K K +G+ N +T+ GHL+E A P+ YD + Sbjct: 4 VILAEKPSQARSYVEAL-KNSTKKEGYFSVSDPVLANETFITYGFGHLVELATPEKYDQK 62 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 Y RW+L++LPI P+K++ Q ++K L +A I+ A D DREG+ + +++ Sbjct: 63 YKRWSLSNLPIFPDKYKFIVPRDKKTQFKIVKDLLMKADTIIIATDSDREGENIAWSIMN 122 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++ + + ++R IN L A+ L+ + P A R +DWL G+N + Sbjct: 123 QAKINLKS-KTIKRLWINSLEKDAILNGFKNLKDAWNYYPAYQEAQTRQISDWLVGMNGS 181 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 YT+L R +G +GV S+GRVQTP L +V +RD+EI+NF + +FE+ A I ++F Sbjct: 182 PLYTLLLRQSGVRGVYSIGRVQTPTLYMVYQRDQEIKNFKPEPYFEISAEIE-ANRQKFV 240 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A P + + +E L A+ + R Q A+ + + ++P FSLS+L Sbjct: 241 AKLDPYQRFK----DEESLTIYMEAKGL--RTGFQEALTKDVLQETKRTASPRLFSLSSL 294 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q KR+ SA +VL Q LYE KL+TYPR+DC Y+ ++ F+ + + Sbjct: 295 QSAINKRYHASASDVLKAVQALYEA-KLLTYPRTDCNYITDQEFSYLLSNLMGYLSLVSS 353 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA----INLTENEAKVYNLIARQYLMQ 413 + + + + R + KKV HHAII T L + + +VY L+ R L Sbjct: 354 QVS--LNNTEANKRYVNSKKVQEHHAIIMTKTIPNKAKLAALPKLQQQVYGLVLRTTLAM 411 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F + + +I ++ K F A + GW+ L + + LP V K ++ Sbjct: 412 FADPYEYEQTIIITEVGKANFKATGNVPIKQGWKLLFADDKDKNDETVVTLPKVTKNQKV 471 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 + +++T PP FT+ TL++AM R + D++ + IL+ +G+GTEATRA ++E Sbjct: 472 QA-DLKTPQKETTPPVPFTEGTLITAMKTAGRTLDDEEAQSILKDVEGIGTEATRANVLE 530 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHS--LPEMATRPDMTAHWESVLTQISEKQCRYQDF 591 +L KRG+L K +H ++ G L + L + T P+MTA WE L +IS+K+ + F Sbjct: 531 VLKKRGYLLSKKNQLHVSEQGITLCTAVELEPLLTSPEMTAKWELALKEISQKKRSQESF 590 Query: 592 MQPLVGTLYQLIDQAKRTPVR--------------------QFRGIVAPGSGGSADKKKA 631 + + + +L+D+ + Q P K Sbjct: 591 LIQIKKFVSKLVDEVPTQMKQSEGLSKQVKNQKIVEIQDRQQEAIGRCPLCKEGMIVDKG 650 Query: 632 APRKRSAKKSPPA 644 K + A Sbjct: 651 ---KFYGCTNYKA 660 >UniRef50_C5NYW8 DNA topoisomerase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYW8_9BACL Length = 702 Score = 533 bits (1372), Expect = e-149, Method: Composition-based stats. Identities = 182/655 (27%), Positives = 311/655 (47%), Gaps = 45/655 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ + + EKPS+AR IA L + K +G +E G+ VVTW +GHL+ PD Y + Sbjct: 1 MKSVVLCEKPSVARDIARNLGAKNNK-NGCLE-GDKYVVTWALGHLITLQTPDKYKE-FN 57 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLD 117 +L +LP++P+ + + KQ V++ L + +E++ A D REG+L+ ++D Sbjct: 58 NVSLENLPMIPKFMKTEIIKKTFKQYKVVENALNRKDVNEVIIATDAGREGELVARYIID 117 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 + + V+R I+ + +A++ L+ E++ L S +ARA ADWL GIN + Sbjct: 118 KAKC----NKNVKRLWISSVTDKAIKDGFRNLKDGKEYLGLYHSGIARANADWLVGINAS 173 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ Y L+ GRVQTP L +V R+E+I+ F KD++ +A I Sbjct: 174 RALTLK-----YNASLNCGRVQTPTLQMVFEREEKIKQFKPKDYYTFEAQIDG------- 221 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + AE + + + K ++ S ++L+ + Sbjct: 222 ----------VKFSCGNSEFNLEKAEQFIKKNINKEIKFNDVQKKAKTSSVKPLYNLTDI 271 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q A+ FG+S + L+I Q LYE HK++TYPR+D RYL + + AI + Sbjct: 272 QQTASALFGMSPKQTLNIVQSLYERHKVLTYPRTDSRYLTSDMKNTLKDRIQAIGGDFKE 331 Query: 358 LLPQPVVDPDIR-NRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLIARQYLMQFC 415 + + + D + ++ KV HHAIIPT + +++++ E K+YNL+A+++L Sbjct: 332 TIAKLLKVKDYNTKKIINNAKVSDHHAIIPTEQKPNYMSMSDMETKIYNLVAKRFLENLL 391 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 P+ + + +I F AK + + G++ L + +D+ + + + Sbjct: 392 PEYKYEETTYSFNIENKVFSAKGLKVIQEGYKELSREELQDKTINL-------QNNNHKL 444 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 E ++QT PP ++T+ TL+ AM FV D++ +KIL+ T+G+GT ATRA I+E L Sbjct: 445 ESLVYNKKQTTPPSYYTEGTLIYAMENPFEFVDDENERKILKETNGIGTVATRADILEKL 504 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPL 595 F +L I +T+ K L + +P+ P +TA WE L I++ + F+ + Sbjct: 505 FTNDYLVLDNGRIKTTNKAKQLLNLVPKNLKSPSLTAVWEKQLDNIAKNKLSKDKFLNDV 564 Query: 596 VGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 I + K + R G G + K SP Sbjct: 565 KDYTKSCIAEIKDSEDRFKHDNISGKKCEECGSFMLEVDKKGTKMLKCSSPSCRN 619 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 532 bits (1371), Expect = e-149, Method: Composition-based stats. Identities = 138/680 (20%), Positives = 253/680 (37%), Gaps = 97/680 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K G V +GH+ + + ++ Sbjct: 5 LVIVESPAKAKTIQKYLGK-------------GYEVEASLGHIKDLPKKGLGVDIENNFD 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P K + +K+ +A I A DPDREG+ + + + L Sbjct: 52 TE----------YVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIAAHLAEELGDG 101 Query: 123 PEKRQ------QVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 K++ R N++ +AV+ A + R L + R D L G + Sbjct: 102 DGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDR--NLVDAQQTRRILDRLVGFQV 159 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 + R LS GRVQT L L+V R+ EI+ FV+K+++ + AH+ F Sbjct: 160 SPLLWDKVRRG-----LSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKPPDF 214 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A + + E+ + + ++ +V+++ V S +++ +A PF+ S Sbjct: 215 DARFTGIDG------EKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSK 268 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVM 348 Q +A+++ G+S + + I Q LYE T LITY R+D + E ++ Sbjct: 269 FQQDASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELI 328 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVY 403 + P LP+ + AH AI P T L ++E KVY Sbjct: 329 GT--SYGPQFLPESPNVYKQKK-----DAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVY 381 Query: 404 NLIARQYLMQFCPDAVFRKCVIELDIA---KGKFVAKARFLAEAGWRTLLGSKERDEEND 460 LI ++++ AVF + +++D F L G+ + + ++ + Sbjct: 382 KLIWQRFVASQMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEE 441 Query: 461 G----TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 LP + +G L + + + T+PP + +A+L+ + Sbjct: 442 DDALKHKLPPLVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEE-------------- 487 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTK---KGRYIHSTDAGKALFHSLP---EMATRPDM 570 G+G +T A I+ + RG++ K +G T+ G + L + Sbjct: 488 ---QGIGRPSTYAAILSTIQDRGYVQKTPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKF 544 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGS 625 T+ E L ++ + Q ++ D ++ +D A++ + + G Sbjct: 545 TSRMEEELDEVEDGQKKWTDTLKEFYDKFETNLDYAQKHMENIKRMEKPTDEKCERCGSP 604 Query: 626 ADKKKAAPRKRSAKKSPPAD 645 K A S Sbjct: 605 LVIKWGKHGSFYACSSYDKK 624 >UniRef50_C6CYM3 DNA topoisomerase n=4 Tax=Bacillales RepID=C6CYM3_PAESJ Length = 770 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 214/670 (31%), Positives = 327/670 (48%), Gaps = 52/670 (7%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKP + R IA V+ ++E G+ ++TW IGHL+ A+PD YD+RY Sbjct: 1 MKTLIIAEKPDMGRTIAAVVEPKAANKRTYLE-GDRFIITWAIGHLVTLAEPDQYDARYK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 RWN DLPI+P+K++L P QL I +V+A D REGQL+ + YL Sbjct: 60 RWNDQDLPIIPDKFKLWPNARTKDQLKTIGELAKRCGRLVNACDAGREGQLIFHLIRQYL 119 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 +L Q R I+DL P+ + + D LRS+ ++ PL +A AR+ ADWL G+N +RA Sbjct: 120 KLP----QPTDRLWISDLTPETIRKGFDSLRSDEDYAPLTRAARARSEADWLIGMNASRA 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +TI ++ +LSVGRVQTPVL L+ R +EI F + ++ VKA +++ I Sbjct: 176 FTIR-----HKALLSVGRVQTPVLALLYDRHKEITAFKSDMYYVVKALF-DQNGFQYSGI 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 WQ R+ + AE + + G+P + Y E L+ LQ Sbjct: 230 WQG-----------DRITDKAKAEALAAKTQGKPGFIKDYQTAESKEYPFRLHDLTLLQR 278 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 EA R+G SA+ LDI Q LYE HK ITYPR++ Y+ EE+ V+ + Sbjct: 279 EANGRYGYSAKKTLDIAQALYEKHKAITYPRTNSNYVTEENLPVMQKVLTMLQGSDSYRE 338 Query: 360 PQPVVDPDI----RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 D + KV+ HHAI+PT + + L+ E +Y++I R++L Q+ Sbjct: 339 LANGADRGRVHKGNKAVCNPSKVEDHHAIMPTPKRPS-GLSPEEQNIYDMIVRRFLSQYY 397 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL------------------GSKERDE 457 P AV++ + ++ F KA+ L E GW+ +L E D+ Sbjct: 398 PPAVYKNHTVLTEVESEIFRTKAKELLELGWKVVLQDQGQAAKKTSKKKSSEKDEAESDD 457 Query: 458 ENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 E T P + + C K E +E+ TQPP+ FT+ TLL AM + ++D +L++ + Sbjct: 458 EELLTDKPFAIEPQQGVKCVKSESLEKTTQPPKSFTEGTLLKAMESAGKSMEDDELREAM 517 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTA 572 + T GLGT ATRA IE L + G++ G+ + + G A + ++ P+MT Sbjct: 518 KDT-GLGTPATRAATIERLKQVGYVDLTGKKLEISSKGCAAIELIRGAGVDLLASPEMTG 576 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAA 632 WE L QIS + F+ + ++D+ ++ SGG Sbjct: 577 RWEQRLHQISRGEASDDQFIMKVKQFAAMIVDKVRQQRPAAPGTFEERESGGKRGAAGTK 636 Query: 633 PRKRSAKKSP 642 R++K S Sbjct: 637 RGSRTSKPSG 646 >UniRef50_A1WZY5 DNA topoisomerase III n=6 Tax=Campylobacter RepID=A1WZY5_CAMJJ Length = 730 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 222/672 (33%), Positives = 352/672 (52%), Gaps = 46/672 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L ++ G+G+I+ G+ +VTW GH+LE A+P+ YD +Y Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNYKSGEGYIQKGDN-IVTWAFGHILELAKPEEYDEKYKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDY 118 W L DLP+ ++++ P+ KQL +I +H + + IV+ GD D EGQ+LVDE++ Y Sbjct: 60 WKLEDLPLPIKEFKYLPKKESKKQLKIICDLIHSDKITSIVNCGDADDEGQILVDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + V R LINDL P+AV+ I +++ N++F + AR++ADW+ GIN+TR Sbjct: 120 ----SKTSKPVFRVLINDLTPKAVKEEIAKIKPNADFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 AYTI+ R GY+G+LSVGRVQTP+L L+V RD+E ENF + +++ + + A Sbjct: 176 AYTIMARKNGYEGILSVGRVQTPILALIVNRDKEFENFKSINYYSLLGDFNINNN-TIKA 234 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + +L LA+ + Q A + + + + E PLP++L LQ Sbjct: 235 RLKTEDK----------ILDENLAKEIKESCENQNAKI-NLKIENKKEYPPLPYNLLVLQ 283 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 E AK FG S L+I Q L E HK ITY RSDC+YLPE F ++N I + Sbjct: 284 AECAKLFGFSPDKTLEITQILREKHKAITYNRSDCQYLPETMFEQAPNILNIIKENLNSN 343 Query: 359 LPQPVV----DPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 + D I+++ ++D + AH+ IIPT + LT++E VYNLIA+++++QF Sbjct: 344 DEIQALIASSDLTIKSKAFNDANISAHYGIIPTQNKISSQLTQDELVVYNLIAKRFIIQF 403 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG-----SKERDEENDGTPLPVVAK 469 ++ I L++ + F A ++G+R+L ++ + END L ++ Sbjct: 404 FHPREYQTTTINLEVNQRIFTATQNKTTKSGFRSLWQNIDSEEEQENNENDINDLSILKN 463 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD--------G 521 GD C ++ ++QT+P ++T TLL + +A++V D+ +KK+L D G Sbjct: 464 GDIAKCSLIQIEKKQTKPRPYYTMTTLLKDLNSVAKYVSDERIKKLLIEKDKDKKGESGG 523 Query: 522 LGTEATRAGIIELLFKRGFLTK---KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 +GT ATR+ I+ L +R ++ K + I ST G+ L P+ PDMTA W Sbjct: 524 IGTPATRSNHIKTLIEREYIEVSKDKKQIIKSTKKGRDLIKLSPKSLITPDMTALWFEQQ 583 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRT------PVRQFRGIVAPGSGGS-ADKKKA 631 I + R + F++ + + I + + I P K+K Sbjct: 584 KMIEISELRREQFLEEITKEVISEIQRIDKNQEFKILDNENKPKIQCPQCNKGFLTKRKG 643 Query: 632 APRKRSAKKSPP 643 Sbjct: 644 KYGNFWGCSEFK 655 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 529 bits (1364), Expect = e-148, Method: Composition-based stats. Identities = 138/672 (20%), Positives = 261/672 (38%), Gaps = 88/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K V +GH+ + + + Sbjct: 5 LVIVESPAKAKTIEKYLGKK-------------YKVIASMGHVRDLPRSQMGVDVEDNYE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +K++ +A + A DPDREG+ + + L+L Sbjct: 52 P----------KYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIAWHLSKILELD 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K R + N++ AV+ + R + L + AR D L G N++ Sbjct: 102 DSKEN---RVVFNEITKDAVKESFKHPRGIE--MDLVDAQQARRILDRLVGYNISPVLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LV+ R+ EI NF ++++ ++ +FTA + Sbjct: 157 KVKKG-----LSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKS-KFTAKFLH 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+++ +L + E V + G +T+ N K ++ + PF+ S LQ EAA Sbjct: 211 ------YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + + + Sbjct: 265 RKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIE--DKY 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-----AINLTENEAKVYNLIARQ 409 D L DAH AI PT+ LT ++ ++Y LI + Sbjct: 323 GKDYLSNRTAKGKQ-------GDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWER 375 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND-GTPLPVVA 468 ++ A+ +++ KF A + + G+ TL + D++N+ LP ++ Sbjct: 376 FVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLS 435 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 KGDE+ + E + TQPP +T+A L+ + + +G +T Sbjct: 436 KGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEEL-----------------KIGRPSTY 478 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A I+ + KR ++ + + T+ G+ ++ + + + T + E++L +I+E Sbjct: 479 APTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAEGD 538 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + G+ +++A+ + + G G K K A Sbjct: 539 IGWRKVIDNFYGSFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACS 598 Query: 641 SPPADEVGSGAI 652 + P + Sbjct: 599 NFPDCRNTKAIV 610 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 529 bits (1363), Expect = e-148, Method: Composition-based stats. Identities = 143/669 (21%), Positives = 261/669 (39%), Gaps = 84/669 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I +L K + V GH+ + + + + Sbjct: 5 KLIIVESPAKAKTIEKILGKDFK-------------VLASYGHIRDLPEKELGVDIENGF 51 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + PS K ++ IK + ++ A DPDREG+ + +++ L+L Sbjct: 52 KP----------KYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLVETLKL 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + R +++ P+A++ AI R + + AR D L G ++ Sbjct: 102 ---PKDKFTRIEFHEITPRAIQEAIRNPRDID--LDKVEAQQARRILDRLVGYELSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L L+ R+EEIE FV ++++ + + Sbjct: 157 EKVRRG-----LSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKDKIIYG---- 207 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 Y++EE + + A+ ++ ++ + K E ++ PLPF S LQ EA Sbjct: 208 ---KLVFYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEA 264 Query: 302 AKRFGLSAQNVLDICQKLYETH-------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++R G + I Q LYE LITY R+D + E + ++ Sbjct: 265 SRRLGFPVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESV--F 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + + + R DAH AI PT+ LTE++ K+Y LI + Sbjct: 323 GKEYVGKE------RKERKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWER 376 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 +L +A++ I++ FV+K R L AG+ +L KE +EE + + + Sbjct: 377 FLASQMANALYDVIEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQE 436 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G ++ + TQPP +T+ATL+ + G+G +T A Sbjct: 437 GSDIDLINLTPKQFFTQPPPRYTEATLVRTLEK-----------------YGIGRPSTYA 479 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQC 586 IIE L +R ++ + + T GK + L + TA E L +I + Sbjct: 480 TIIETLKERKYVEVSKKELVPTTLGKVVNEFLTKQFPHLIDVKFTAKMEEDLDKIESGEV 539 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 + + ++ + + +++ + + + P G ++ K A + Sbjct: 540 KAIEVLEKFYPSFKEELERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAY 599 Query: 643 PADEVGSGA 651 P + Sbjct: 600 PECKYTKPI 608 >UniRef50_A9GNF4 DNA topoisomerase n=2 Tax=Bacteria RepID=A9GNF4_SORC5 Length = 1476 Score = 528 bits (1361), Expect = e-148, Method: Composition-based stats. Identities = 209/731 (28%), Positives = 327/731 (44%), Gaps = 106/731 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M +AEKP++AR IA VL ++ +GF+E G G VVTW IGHL+ A+P D + R Sbjct: 1 MIAVVAEKPAVARDIAAVLGA-SKRAEGFLEGG-GYVVTWAIGHLVAIAEPHQIDPAWKR 58 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W L LP++P ++ L P Q ++++ L + +V A D REG+L+ + + Sbjct: 59 WRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEA 118 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V+R I+ L P A+ + RLR + L +A R+RADWL G+N++R Sbjct: 119 AGC----KKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSR 174 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---------- 228 AY+++ + LSVGRVQTP L +VV R+ I FV + + EV A Sbjct: 175 AYSLV-----FDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGA 229 Query: 229 ------------------------VTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEH 264 A ER A +P+ P E RP Sbjct: 230 ADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAP 289 Query: 265 VVNRI--------------SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQ 310 R+ A + + + PL + L+ LQ A + +G SAQ Sbjct: 290 SRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQ 349 Query: 311 NVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRN 370 L++ Q LYE KLI+YPR+D R+L E A A + AI +L + Sbjct: 350 KTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGK 409 Query: 371 RCWDDKKVDAHHAIIPTA-RSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI 429 R DD KV HHAIIPT RSS L+ +E K+++LI R+ L + D V + I Sbjct: 410 RFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAI 469 Query: 430 AK-------------GKFVAKARFLAEAGWRTL---------LGSKERDEEND------- 460 ++ + + + GW+ L ++ + + D Sbjct: 470 TTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDA 529 Query: 461 -------------GTPLPV-VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 LP +A+G L E ++T+PP FT+ATLL+AM Sbjct: 530 RDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSS 589 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT 566 +++K+L ++ + GLGT ATRA IIE L +R ++ +KG+ +H+TD G L + Sbjct: 590 LEEKELSAAMKDS-GLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVK 648 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 P MT WE+ L +++ FM + + Q++ + G ++P +G S Sbjct: 649 SPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASP 708 Query: 627 DKKKAAPRKRS 637 +++ R R+ Sbjct: 709 FQERGEARSRA 719 >UniRef50_C3R3E4 DNA topoisomerase I n=4 Tax=Bacteroides RepID=C3R3E4_9BACE Length = 698 Score = 527 bits (1357), Expect = e-148, Method: Composition-based stats. Identities = 193/669 (28%), Positives = 304/669 (45%), Gaps = 51/669 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ K DG+I GNG +VTW +GHL+ A P Y Y R Sbjct: 1 MIAIIAEKPSVGQEIARVVGA-TEKKDGYI-TGNGYMVTWALGHLVSLALPGTYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRP-----------SVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++PE ++L R + +QL VI E I+ A D REG+ Sbjct: 57 TTAEDLPMLPEPFRLVERQIRTDRGMVTDIAAGRQLKVIDGVFSECDSIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +L + +R + L +A+ + + LR E+ L +A +RA+AD Sbjct: 117 LIFRWIYSHLGCT----KPFKRLWFSSLTDEAIRKGMADLREGYEYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N +RA + +A S+GRVQTP L ++ R +E NFV+ ++++ + Sbjct: 173 WLVGMNASRALAAVSGSANN----SIGRVQTPTLAMICARFKENRNFVSTPYWQLHITLK 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDKRESESA 288 R + AE RI G +T + A Sbjct: 229 QGEAHRL-------------FIHPEHFGDKKAAETAYGRIIPGSAVTITKVERGTVFQQA 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L++LQ + L+A L I Q LYE KL++YPR+ RY+PE+ A A++ Sbjct: 276 PLLYDLTSLQKDCNIHHDLTADKTLSIAQSLYE-KKLVSYPRTGSRYIPEDIMANIPALL 334 Query: 349 NA-ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 I++ + + R D KV HHA+I T + L+E E+ VY LIA Sbjct: 335 EKIIAMPLFREYGRTFDFSALNTRSVDTTKVTDHHALIITGVAPE-ELSEAESAVYTLIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKER---DEENDGTPL 464 + L F P + ++E F +++ F+ GWR + KE DE DG Sbjct: 394 GRMLEAFSPPCEKERLLMECMCGGMDFRSRSAFIVNTGWRAVFARKEDREKDEPEDGGGT 453 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 + A+G + + +++T P +T+ATLL+AM + + D + ++ ++ + G+GT Sbjct: 454 ALFAEGGLVPLSGRGLSQKKTLPRPLYTEATLLAAMENCGKDITDGEARETVKDS-GIGT 512 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT-RPDMTAHWESVLTQISE 583 ATRA II LFKR ++ + G+ I T+ G L+ S+ +M ++T WE L +I Sbjct: 513 PATRAAIITTLFKRNYVERSGKSILPTEKGLYLYESVKDMMVADAELTGTWERALARIEG 572 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 + FM + ++ + R P S K A K Sbjct: 573 RTLDPDSFMLSIREYTGKVTGEILRLK------FPEPSSHAFTCPKCKAGNVVVKSKVAK 626 Query: 644 ADEVGSGAI 652 D G G + Sbjct: 627 CDREGCGLL 635 >UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C6P2V7_9PROT Length = 876 Score = 527 bits (1357), Expect = e-148, Method: Composition-based stats. Identities = 150/672 (22%), Positives = 249/672 (37%), Gaps = 80/672 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ + L K V GH+ + + Sbjct: 5 LLIVESPAKAKTLKKYLGK-------------DFEVLASYGHVRDLIPKTGAVDPDDNFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + K ++ I + EA I A DPDREG+ + + + L+ Sbjct: 52 M----------KYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIAWHISELLKGK 101 Query: 123 PEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + +QR + ++ AV A+ R S +PL + AR D+L G N++ Sbjct: 102 RALKGKTMQRVVFYEITQSAVREAVAHPREIS--IPLVNAQQARRALDYLVGFNLSPLLW 159 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+P L L+V R+ EIE F +++++ V F A Sbjct: 160 RKIRPG-----LSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLD-SQKNSIPFKAKLY 213 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESESAPLPFSLSALQI 299 + E+ + + + + ++ P V K + S PF+ S LQ Sbjct: 214 QFQGKRM---EQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQ 270 Query: 300 EAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA ++ G+++ + Q LYE T LITY R+D L E A + Sbjct: 271 EAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIK--D 328 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 A D LP +++ +AH AI PT+ + L ++ ++Y +I Sbjct: 329 NFAGDYLPVKQPVYKSKSK----NAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIW 384 Query: 408 RQYLMQFCPDAVFRKCVIELD--IAKGKFVAKARFLAEAGWRTLL-GSKERDEENDGTPL 464 ++ L A F +++ F A + L G+ + + EE D L Sbjct: 385 KRTLASQMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKL 444 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 P + +GD L +K + TQPP F++A+L+ A+ G+G Sbjct: 445 PPLVEGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEE-----------------YGIGR 487 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQI 581 +T A II L R + T + TD G+ + L E TA+ E L I Sbjct: 488 PSTYATIISTLQAREYATLDKKRFMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDI 547 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 SE + + + +LI + K P + P G K+ Sbjct: 548 SEGKRDWIPVLNEFWKGFNKLISEKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGC 607 Query: 640 KSPPADEVGSGA 651 P + Sbjct: 608 TGYPECDYTRSL 619 >UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium hafniense RepID=B8G1K2_DESHD Length = 777 Score = 526 bits (1356), Expect = e-148, Method: Composition-based stats. Identities = 190/672 (28%), Positives = 333/672 (49%), Gaps = 32/672 (4%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY---DSRYA 59 L IAEKPS AR A L ++ +G+ E + +++WCIGHL E P+ Y Sbjct: 5 LIIAEKPSQAREYAKTLGVKGKR-EGYFE-NDEYIISWCIGHLFELKAPENYMDLPKVGK 62 Query: 60 RWNLADLPIVPE--KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 RW++ LP++P ++Q + KQ V++ L E +++ D DREGQLL EV Sbjct: 63 RWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEV 122 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 D + ++ + R I+ L +A+ + +LR E L + R+ DW +G+N Sbjct: 123 WDAVG----SKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMN 178 Query: 176 MTRAYTILGRN----AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 +T +T L + V+S+GRVQTP L LVV ++ IENFV + EV+A + Sbjct: 179 LTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASG 238 Query: 232 ADERFTAIWQPSEACEPYQDEEG----RLLHRPLAEHVVNRISGQPAIVTSYNDKRESES 287 + P+ +++E +L + +V ++ G+P + S DK E Sbjct: 239 QGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEP 298 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PL F L++L + A+KR+G A+ VL I Q LYE K ITYPR+DC YLP + Sbjct: 299 HPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYE-KKAITYPRTDCNYLPPDMLPKLKVH 357 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 + A+ + +D + ++ AHHAIIPT NL+ +E K++ +I Sbjct: 358 LQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIPNLSPDERKIWEMIV 417 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 ++L + P A + + + + + F+ K + L E+GW+ + +++ E G LP++ Sbjct: 418 LRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENTEKYTE-GSGLQLPLL 476 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 + +E++ + ++++T+PP+ +T L+ AM G + ++D+ L++ L+ GLGT AT Sbjct: 477 QQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKGK-GLGTVAT 535 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE------MATRPDMTAHWESVLTQI 581 R IIE L RG+L ++ + + T G L + E + +MT E L Q+ Sbjct: 536 RGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQMEYELAQV 595 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSADKKKAAPRKRSAK 639 + +M+ + + +I++ + + + + AP G++ +K + + + Sbjct: 596 ERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAPQKAGASGRKSKSNLEEKPQ 655 Query: 640 KSPPADEVGSGA 651 + P +V A Sbjct: 656 ELPVQAKVTKAA 667 >UniRef50_C2MEK2 DNA topoisomerase III n=3 Tax=Bacteria RepID=C2MEK2_9PORP Length = 699 Score = 526 bits (1354), Expect = e-147, Method: Composition-based stats. Identities = 179/656 (27%), Positives = 302/656 (46%), Gaps = 47/656 (7%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 I EKPS+A IA VL K +G++ + +TW GHL+ A P Y + + Sbjct: 7 IITEKPSVAMDIAKVL-NVTHKSEGYLY-NDQYKITWAYGHLVALADPQTYG--FTSYAR 62 Query: 64 ADLPIVPEKWQLQPRPSVTK-------------QLNVIKRFLHEASEIVHAGDPDREGQL 110 +LP++P+ ++L R K QLNVIK+ + I+ A D REG+L Sbjct: 63 EELPMLPKPFKLVVRQVKKKDGKGYEEDDFARKQLNVIKQCFDSSERIIVATDAGREGEL 122 Query: 111 LVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADW 170 + + YL + + R ++ + QA+ A +L+ + L ++ AR+ ADW Sbjct: 123 IFRYIYYYLGCS----KPFDRLWLSSMTDQAIRDAFTKLKEGQLYDNLYLAGKARSEADW 178 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 L G+N +RA TI + G LS+GRVQTP L ++ R +NFV F+++ A + + Sbjct: 179 LVGMNASRALTIA---SNGSGGLSLGRVQTPTLCMICDRYLSNKNFVKSPFWKINAQVKS 235 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAP 289 + FT + ++ LA+ + +S VT K S P Sbjct: 236 -GETTFTV------------SSPEPITNKGLADSKLYAVSNLTSLTVTKAERKSTSSQPP 282 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L + L+ LQ EA K+ G +A+ L+I Q LYE K+ TYPR+ RY+P++ + ++ Sbjct: 283 LLYDLTTLQKEANKQ-GFTAEQTLNIAQSLYE-KKVTTYPRTGSRYIPKDVYDTMSYLLR 340 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 + + Q ++ + DD K+ HHAII T + +LTE+EA +Y +IA + Sbjct: 341 QLPYQEYQIYAQGLIVAGLNPHSVDDSKITDHHAIITTGET--ADLTEDEAIIYKMIAMR 398 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG---TPLPV 466 L P + + L + V + + GWR + G D ++D LP Sbjct: 399 MLEAVSPASNKELLSLTLSGGGEELVTTLSCIKKKGWRVVKGETTEDPDSDEVSLNSLPS 458 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +A G EL + + E +T+P +T+ATLL AM + ++DK+ ++ ++ GLGT A Sbjct: 459 IADGMELSLVQATLKEGETKPKPIYTEATLLGAMERAGKEIEDKEAREAMQDV-GLGTPA 517 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT-RPDMTAHWESVLTQISEKQ 585 TRA IIE L ++ + ++ + T+ G +++ + ++T WE L +I Sbjct: 518 TRASIIEKLLRQNYAVRQKNQLIPTERGLVVYNLVKSRLIGNAELTGQWEKSLAEIEAGN 577 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 F + Q+ D+ T V + P + + + + Sbjct: 578 LPPTTFNSQIEDYTKQITDELLSTSVSLGTNYICPLCHQESVRIYSKSMRCQNDGC 633 >UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms RepID=D0LR99_HALO1 Length = 894 Score = 526 bits (1354), Expect = e-147, Method: Composition-based stats. Identities = 134/679 (19%), Positives = 236/679 (34%), Gaps = 95/679 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR I L V +GH+ + + + Sbjct: 139 LVVVESPAKARTIGKYLG-------------PDYTVKASVGHIKDLPKNKIGVDVDQAFE 185 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 K ++ I++ E+ A DPDREG+ + + + ++ Sbjct: 186 PE----------YVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIK-- 233 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R LIN++ + V AI + AR D L G ++ Sbjct: 234 -PINDNIKRILINEITKKGVNHAIANPTVLD--TNKTDAQQARRILDRLVGYEISPILWK 290 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ + L+V RD+EI F ++++ V P F A Sbjct: 291 KVRRG-----LSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHR 345 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + A + + + Q A V K PF S LQ EA+ Sbjct: 346 WDGAKAEP------KTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEAS 399 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ SA+ + + Q+LYE LITY R+D + ++ A + + Sbjct: 400 RKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQ--GTY 457 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA----------KVYN 404 P+ LP R DAH AI PT K+Y Sbjct: 458 GPEFLPAKPHTYKSPKR-----AQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYT 512 Query: 405 LIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE------ 458 LI ++++ AV+ + +++ + A + + G+ ++ ++E D+E Sbjct: 513 LIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAA 572 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + LP + +G + + + TQPP FT+A+L+ + Sbjct: 573 DQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEE---------------- 616 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWE 575 G+G +T A II + RG++ ++ T+ G + L E D TA E Sbjct: 617 -RGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAME 675 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV-----RQFRGIVAPGSGGSADKKK 630 + L ++ E + +++ + I+ AK V G K Sbjct: 676 ADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKW 735 Query: 631 AAPRKRSAKKSPPADEVGS 649 A ++ P Sbjct: 736 GRNGSFLACQAYPDCRNTK 754 >UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP1_STAA8 Length = 689 Score = 525 bits (1353), Expect = e-147, Method: Composition-based stats. Identities = 133/672 (19%), Positives = 251/672 (37%), Gaps = 88/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K V +GH+ + + + Sbjct: 5 LVIVESPAKAKTIEKYLGKK-------------YKVIASMGHVRDLPRSQMGVDTEDNYE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +K+ +A + A DPDREG+ + + L+L Sbjct: 52 P----------KYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELE 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K R + N++ AV+ + R + L + AR D L G N++ Sbjct: 102 DSKEN---RVVFNEITKDAVKESFKNPREIE--MNLVDAQQARRILDRLVGYNISPVLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LV+ R+ EI NF ++++ ++ +F A + Sbjct: 157 KVKKG-----LSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKS-KFNAKFLH 210 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+++ +L + E + + G +T+ K ++ + PF+ S LQ EAA Sbjct: 211 ------YKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAA 264 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + + Q+LYE T LITY R+D + + + + Sbjct: 265 RKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYI--TDKY 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 R DAH AI P T LT+++ ++Y LI + Sbjct: 323 GESY-------TSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWER 375 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVA 468 ++ A+ +++ KF A + + G+ TL + D + LP + Sbjct: 376 FVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLE 435 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GD++ + E + TQPP +T+A L+ + + +G +T Sbjct: 436 QGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEEL-----------------KIGRPSTY 478 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A I+ + KR ++ + + T+ G+ + + E + T + E++L +I+E Sbjct: 479 APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD 538 Query: 586 CRYQDFMQPLVGTLYQLIDQA-----KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + + Q +++A K + G G K K A Sbjct: 539 ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS 598 Query: 641 SPPADEVGSGAI 652 + P + Sbjct: 599 NFPDCRNTKAIV 610 >UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7W1_9DELT Length = 821 Score = 525 bits (1353), Expect = e-147, Method: Composition-based stats. Identities = 132/662 (19%), Positives = 243/662 (36%), Gaps = 79/662 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + I+ L K +V +GH+ + D + Sbjct: 5 LIIVESPAKVKTISKFLGK-------------DYMVDASVGHVRDLPTRDLGVDEENGFT 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + + +K +A + A DPDREG+ + V + L+ Sbjct: 52 P----------RYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLR-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R N++ +AV+ A++ + ++ L S AR D L G ++ Sbjct: 100 -PVNSNIRRIQFNEITARAVKEALENAQDLNQ--NLFDSQQARRILDRLVGYKISPILWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + +S GRVQ+ L L+V R++E F +++ K + F Sbjct: 157 NVKRG-----ISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + + + AE + + V S +K+ P+ S LQ +A Sbjct: 212 LSG-KAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDAN 270 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G SA+ + + Q+LYE T LITY R+D + +E ++ I Sbjct: 271 RRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELI--IDRF 328 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 D P RN DAH AI P T +L + K+Y LI ++ Sbjct: 329 GADYYP-----SKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQR 383 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 ++ A F + + ++ AK L G+ + + E + LP + + Sbjct: 384 FVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETE---LPKLVE 440 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L + + ++ TQPP +++A+L+ + + +G +T A Sbjct: 441 GETLRLNELKKEQKFTQPPPRYSEASLVKTLEELG-----------------IGRPSTYA 483 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 II L R + ++ + T+ G + L E TA ES+L ++ + Sbjct: 484 AIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQ 543 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + ++ Y +++A+ R Q IV G K + P Sbjct: 544 DWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPT 603 Query: 645 DE 646 Sbjct: 604 CR 605 >UniRef50_B1F998 DNA topoisomerase n=1 Tax=Burkholderia ambifaria IOP40-10 RepID=B1F998_9BURK Length = 690 Score = 525 bits (1352), Expect = e-147, Method: Composition-based stats. Identities = 227/663 (34%), Positives = 348/663 (52%), Gaps = 25/663 (3%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY--- 58 RL+IAEKPSLA+ + V + + G V GH+L QA PD Y Sbjct: 3 RLYIAEKPSLAKDVMAVFDGRPSRNGPAYKVGGDFFV-PLKGHILAQAMPDFYLPDDVPL 61 Query: 59 -----ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVD 113 W +DLP++P W LQP+ L+ I++ L E+VH GDPD EGQLLVD Sbjct: 62 NRNGNKIWRASDLPVIPSTWILQPQEEHASILDAIRQLLANVDEVVHLGDPDAEGQLLVD 121 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADWL 171 EVL+YL V+R L+N+ NP + +A+ LR+N E F ALAR+R DWL Sbjct: 122 EVLEYLG----NTLPVKRLLVNNNNPNEIRKALANLRNNDEPEFRAWHRWALARSRYDWL 177 Query: 172 YGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 +G+N TRA T ++ G+ +LSVG VQTPVL +V RD++IE F +F + A + Sbjct: 178 FGLNFTRAATCRAQSLGFDALLSVGSVQTPVLQIVFERDDKIERFKPTSYFLLSAQLQHA 237 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 FTA W+ ++ + DE+GRL+ +A + ++ PA V+++ K + APLP Sbjct: 238 KGA-FTAKWRAADD-QLGLDEDGRLVDPDVAAALAQSLTNAPATVSAFERKPARDLAPLP 295 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 SL+ L +EA +RFG +A VLD Q+LY+ +KL TYPR++ RYL E + A+ Sbjct: 296 LSLNELTVEACRRFGCTAAEVLDAAQELYDRYKLTTYPRTENRYLAEAQHDEAPDALAAL 355 Query: 352 SVHAPDLLPQ-PVVDPDIRNRCWDDKKVD--AHHAIIPT-ARSSAINLTENEAKVYNLIA 407 + + DL P D +R+R +DD+K+D HH I+PT R+ LT + +VY+LI Sbjct: 356 AANRADLAPLVDRADLTLRSRAFDDEKMDGDPHHGIVPTARRADLSTLTPLQHQVYDLIV 415 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 R YL+QF P A F + IE++ + +A R +GW +L E + ++D LP + Sbjct: 416 RYYLVQFYPAATFMQTSIEVESGGNRLIAGGRTPVSSGWLAVLKPSEPETDDDVQMLPQL 475 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 A GD+LL ++ ++T+PP F +ATL+ AM + ++ D K L+A G+GT AT Sbjct: 476 AVGDQLLVIDVDLQAKETRPPARFDEATLIDAMIDLHKYTDDPAAKARLKAGKGIGTSAT 535 Query: 528 RAGIIELLFKRGF---LTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEK 584 RAGII +RGF + ++ +AL +LPE P + ++ L +++ Sbjct: 536 RAGIIAEHRERGFLVPVKGSKTRFMTSPTARALLAALPEPVKDPTVAGMFKIALDAVADG 595 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGS-GGSADKKKAAPRKRSAKKSPP 643 + + FMQ + +++ P++ P G + + Sbjct: 596 EMTFDAFMQRSEKMVTRIVGVIAEAPMQLPGARPCPVCETGQLRRINGQDGPFWGCSNYK 655 Query: 644 ADE 646 A++ Sbjct: 656 AEQ 658 >UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales RepID=C6BUQ9_DESAD Length = 800 Score = 525 bits (1352), Expect = e-147, Method: Composition-based stats. Identities = 139/662 (20%), Positives = 250/662 (37%), Gaps = 84/662 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ + I+ L + V +GH+ + + + Sbjct: 5 LIVVESPAKVKTISKFLGR-------------NYQVAASVGHVRDLPKNKLGVEENGDFT 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q Q P +N +K+ +A + A DPDREG+ + V ++ Sbjct: 52 P----------QYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIK-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 E + V R N++ +AV+ A++ + +E L S AR D L G ++ Sbjct: 100 -EVNENVSRIQFNEITARAVKEALEHPQPLNEQ--LFDSQQARRILDRLVGYKISPILWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + +S GRVQ+ L LVV R++ F+ ++++ KAH+ F A Sbjct: 157 KVKRG-----ISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + ++ + AE + + + G P +T +K + P+ S LQ +A Sbjct: 212 VDG------KKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDAN 265 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G SA+ + + Q+LYE T LITY R+D + E V+ + + Sbjct: 266 RRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVI--LDKY 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQ 409 + P + DAH AI P L ++ KVY LI + Sbjct: 324 GDEFYPAKPQVYKSK-----GGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNR 378 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 ++ A F V+ + + +K L G+ + G ++ LP + K Sbjct: 379 FIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEK---LIELPKLEK 435 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L +K E ++ TQPP +++A+L+ + G+G +T A Sbjct: 436 GEVLKVDKIESEQKFTQPPARYSEASLVRELEE-----------------KGIGRPSTYA 478 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 II + RG++ + + T+ G + L E TA E L +++ + Sbjct: 479 SIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKI 538 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + M+ V Y ++ A + R + GI K + + P Sbjct: 539 EWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPE 598 Query: 645 DE 646 + Sbjct: 599 CK 600 >UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=A8U720_9LACT Length = 713 Score = 524 bits (1350), Expect = e-147, Method: Composition-based stats. Identities = 189/667 (28%), Positives = 325/667 (48%), Gaps = 46/667 (6%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ + +AEKPS A+A A+ K +K I + ++TW GHL+E A P+ Y + Sbjct: 1 MKRVILAEKPSQAQAYAESFGKFSKKDGYIILNPSNDIITWGFGHLVELASPEEYRDEWK 60 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 +WN+ +LPI+P+ ++ + +KQ N+IKR L EA +IV A D DREG+ + ++ Sbjct: 61 KWNMKELPIIPQTFKFKVGQGKSKQFNIIKRLLKEADQIVIATDSDREGENIARSIISQA 120 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + ++++R IN L +++ LR +F + A R +DWL GIN++R Sbjct: 121 KAD---NKEIKRLWINSLEADEIQKGFSDLRDGKDFYSAYIEAQTRQISDWLVGINLSRM 177 Query: 180 YTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 YT+ + G GV SVGRVQTP L ++ R +EIENF+ + FFE+ A I F A Sbjct: 178 YTLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKEIENFIPEPFFEMHATIKAEKG-SFKA 236 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + ++ P +++ KR S+ +P FSLS LQ Sbjct: 237 KYNKKFPTKK---------ELQDLIKKHELLASNPGVISDIGTKRISQPSPFLFSLSDLQ 287 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 K++ +S + L Q LYE KL++YPRSDCR++ + F ++ Sbjct: 288 SLINKKYKVSPSDTLKHVQSLYEA-KLLSYPRSDCRHITDSEFHYLIERIDGYQSVLNYT 346 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA----INLTENEAKVYNLIARQYLMQF 414 + QP + R R D KV H+AIIPT + LT + ++Y + ++ + F Sbjct: 347 IEQP--NTSKRKRYVDGSKVQEHYAIIPTKKVPTQKELDKLTSIQKEIYYTVLKRTMAMF 404 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTL-LGSKERDEENDGTPLPVVAKGDEL 473 D + + I ++I K F++K R + + GWR L + ++ ++ + T LP+V K + + Sbjct: 405 ETDYKYDETTITVEIKKLPFISKGRTILDKGWRKLEYAASKKTDKEENTELPLVQKNEAI 464 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 E T PP+ +T+ TL++AM + +++ + K+IL+AT+G+GTEATRA ++E Sbjct: 465 EA-DLATSEGFTAPPKSYTEGTLITAMKTCGKELENVEEKEILKATEGIGTEATRANVLE 523 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEKQCRYQDFM 592 L K+ ++ + + T G L ++ + + P+MTA WE+ L +I +++ + F+ Sbjct: 524 TLKKQHYIEIQKNDVTVTQKGAILCQAVKNTLLSSPEMTAKWETYLKKIKKEEGTQEAFL 583 Query: 593 QPLVGTLYQLIDQA-----------------KRTPVRQFRGIVAPGSGGSADKKKAAPRK 635 + + + + + + + P G S K Sbjct: 584 ENIQKFIDHTLASSAQVIESSDWSTRITSMNQTISQTKQTIGTCPACGQSII----DKGK 639 Query: 636 RSAKKSP 642 Sbjct: 640 FYGCSGY 646 >UniRef50_C7XFN2 DNA topoisomerase I n=3 Tax=Bacteroidales RepID=C7XFN2_9PORP Length = 698 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 187/671 (27%), Positives = 299/671 (44%), Gaps = 55/671 (8%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M IAEKPS+ + IA V+ K DG+I GNG +VTW +GHL+ A PDAY Y R Sbjct: 1 MIAIIAEKPSVGQDIARVVGA-TEKKDGYI-VGNGYMVTWALGHLVSLALPDAYG--YTR 56 Query: 61 WNLADLPIVPEKWQLQPRP-----------SVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 DLP++P+ ++L R + +QL VI L I+ A D REG+ Sbjct: 57 TAAEDLPMIPDPFRLVVRQVRTDRGMVTDIAAGRQLKVIGEVLAGCESIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + YL + +R I+ L +A+ + L+ + + L +A +RA+AD Sbjct: 117 LIFRWIYSYLGCT----KPFKRLWISSLTDEAIREGMASLKEGTGYDSLYAAADSRAKAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL G+N +RA + S+GRVQTP L ++ R +E NFV+ ++++ + Sbjct: 173 WLVGMNASRALAAASGSVNN----SIGRVQTPTLAMICARFKENRNFVSTPYWQLHIVLK 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESA 288 R + +AE I+ + +T + + A Sbjct: 229 RDNGHR-------------QFIHTKEFKDKNMAEAAYKSITPRSVVTITKVKRGKIFQQA 275 Query: 289 PLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 PL + L+ALQ + + L L I Q LYE KL++YPR+ RY+P++ A ++ Sbjct: 276 PLLYDLTALQKDCNIHYDLPVDKTLAITQSLYE-KKLVSYPRTGSRYIPQDVMAHIPVLL 334 Query: 349 NAISVHAP-DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 I+ + + + R D KV HHA+I T L+E E+ VY LIA Sbjct: 335 EKITAMPEFREYRRSLDLSALNTRSVDAAKVTDHHALIITGIVPE-GLSEAESTVYTLIA 393 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKER---DEENDGTPL 464 + L F P ++E F +++ +A GWR + KE DE Sbjct: 394 GRMLEAFSPPCEKELLLMECVCGGLDFHSRSTVIANPGWRAVFSRKEDREKDEPERDEGT 453 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 +G+E+ + +++T P +T+ATLL+AM + + D ++ ++ T G+GT Sbjct: 454 ASFTEGEEIPVMGHGLSQKKTLPKPLYTEATLLTAMENCGKEITDGQAREAVKDT-GIGT 512 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMAT-RPDMTAHWESVLTQISE 583 ATRA II L KR ++ + G+ I T+ G L+ S+ +M +T WE L QI Sbjct: 513 PATRAAIITTLLKRDYIERSGKSIRPTEKGLYLYESVKDMMVADAKLTGTWEKALEQIEG 572 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--APGSGGSADKKKAAPRKRSAKKS 641 + + FM + ++ + R + V P K+ K Sbjct: 573 RTLDPESFMLSIREYTGKVTGEILRLKFPEPSSCVLACPKCKTGNVVVKS--------KV 624 Query: 642 PPADEVGSGAI 652 D G G + Sbjct: 625 AKCDREGCGLL 635 >UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus RepID=Q7NGH1_GLOVI Length = 765 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 135/677 (19%), Positives = 243/677 (35%), Gaps = 88/677 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ +L K VV GH+ + Q + + + Sbjct: 5 LVIVESPAKAKTISKILGK-------------NFVVKASAGHIRDLPQKEMGVNVKNDFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + P + + +K A + A DPDREG+ + + L + Sbjct: 52 P----------KYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIAWHLAQILDIP 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + ++QR +++ QA++ A+ R + + AR D L G ++ Sbjct: 102 GD---RLQRIEFHEITKQAIQNAVAHPRDID--INRVDAQQARRILDRLVGYKLSPLLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + L+ R++EI+ FV+++++ V A T Sbjct: 157 KVQRG-----LSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPF--- 208 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 S + ++ L + A VV ++G + V S + + PF S LQ E A Sbjct: 209 SADLVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGA 268 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 GL+ + + I Q+LYE LITY R+D + EE + ++ + Sbjct: 269 SALGLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFI--LAAY 326 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P R DAH + PT + + LT ++ K+Y LI ++ Sbjct: 327 GKSYYP-----SRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQR 381 Query: 410 YLMQFCPDAVFRKCVIELDI------AKGKFVAKARFLAEAGWRTLLGSKERD----EEN 459 + A +E+ F G+ + + +E Sbjct: 382 FTASQMTAATLETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGDEE 441 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 PV+ +G+ L + + TQPP F++ATL+ A+ Sbjct: 442 AAGAAPVLEEGEALTLLTVDPKQHFTQPPARFSEATLVKALEE----------------- 484 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 G+G +T A I + +RG++ K GR + TD G + L + + TA+ E+ Sbjct: 485 QGIGRPSTYAPTIGTIQERGYVNKDGRTLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEA 544 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR--QFRGIVAPGSGGSADKKKAAPR 634 L ++ + R+ + G + + A R + G + Sbjct: 545 QLDEVEKGSQRWTQLLADFYGPFVETLKAADEEMKRVVIVTDHLCESCGRPLLNRYGRFG 604 Query: 635 KRSAKKSPPADEVGSGA 651 P + Sbjct: 605 NFLGCSGYPECDFTHQL 621 >UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP2_VEIPT Length = 791 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 131/670 (19%), Positives = 241/670 (35%), Gaps = 87/670 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ ++ I L VV +GHL + + + Sbjct: 75 LVIVESPAKSKTIEKFLG-------------PNYVVKASMGHLRDLPKSQIGIDIEHDFT 121 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + K ++ + + E+S ++ A DPDREG+ + + L + Sbjct: 122 P----------RYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISWHLAYILNVD 171 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P R N++ AV A+D R+ + + + AR D + G ++ Sbjct: 172 PTSTC---RITFNEITKNAVAEALDSPRTID--MNMVDAQQARRVLDRIVGYKLSPLLWK 226 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 LS GRVQ+ + L+ R+ EI+ FV ++++ ++ + TP E F A Sbjct: 227 KVCKG-----LSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTH 281 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + E+ + A+ +V+ I + A+VT+ ++ S A PF+ S LQ + Sbjct: 282 IKG------EKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGV 335 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ A+ + I Q LYE LITY R+D + +E A + + + Sbjct: 336 RKLNFGAKRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFI--LRNY 393 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-----RSSAINLTENEAKVYNLIARQ 409 D P + DAH AI PT+ + L+ +E K+Y LI + Sbjct: 394 GEDYYPSKPNVYGSK-----GSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNR 448 Query: 410 YLMQFCPDAVFRKCVIELDI-AKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 ++ IEL++ F A + G+ + E ++ D LP + Sbjct: 449 FMASQMAPQQNESTTIELNVKNDYTFKATGSRVIFPGFSAVY---EDAKKEDVPQLPALK 505 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 K + + TQPP +++A+L+ + + +G +T Sbjct: 506 KNYAAHTVEVLPEQHFTQPPPRYSEASLIKTLEELG-----------------IGRPSTY 548 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEKQ 585 A I++ + R ++ + T+ G + L E T E L I+ + Sbjct: 549 APILDTIVSRNYVENTNKQFVPTELGFVVVDFLITYFEKIINTGFTRDLEEELDAIASGK 608 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQF----RGIVAPGSGGSADKKKAAPRKRSAKKS 641 Y + Q ++ A + + K K A + Sbjct: 609 DTYVKVLSDFYEVFAQELEDASDVDRIEIASMESDEICELCNSPMVYKFGRYGKFLACSN 668 Query: 642 PPADEVGSGA 651 P + Sbjct: 669 FPECKNTKPI 678 >UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria RepID=B1M0P4_METRJ Length = 894 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 135/695 (19%), Positives = 249/695 (35%), Gaps = 98/695 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ + E P+ A+ I L + V GH+ + D Sbjct: 1 MKVVVVESPAKAKTINKYLGR-------------DYEVIASFGHIRDLPPKDGSVDPEQD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + +++ I + + A +++ A DPDREG+ + VL+ L Sbjct: 48 FRMV----------WELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHVLEALT 97 Query: 121 LAPEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + V+R N + +VE+A+ + R + L + LAR D+L G N++ Sbjct: 98 ARKALKGIPVERVTFNAITKASVEQAMRKPREIDQ--ALVDAYLARRALDYLVGFNLSPV 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 G S GRVQ+ L LVV R+ EIE F ++++ + A + T F A Sbjct: 156 LWRKL-----PGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ + + G A + V S K PF+ S LQ Sbjct: 211 LVGADGKRIQRLDVG---TGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G++ + + Q+LY ET +ITY R+D + E V+ Sbjct: 268 EASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVI---- 323 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + V D + +AH A+ PT L +A++Y LI Sbjct: 324 --GKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELDIA----KGKFVAKARFLAEAGWRTLLGS-KERDEENDGT 462 + + A + +++ A + + G+ TL K+ +E+ + Sbjct: 382 TRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESR 441 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + GD L E+ + T+PP +++A+L+ M + + Sbjct: 442 RLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A +++ L R ++ + + + D G+ + L D TA E L Sbjct: 485 GRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------------------A 619 ++S + ++ ++ I + K V + Sbjct: 545 RVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTC 604 Query: 620 PGSG-GSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 P G G K + P + A Sbjct: 605 PTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSA 639 >UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae RepID=A8ZW15_DESOH Length = 758 Score = 523 bits (1346), Expect = e-146, Method: Composition-based stats. Identities = 133/669 (19%), Positives = 243/669 (36%), Gaps = 88/669 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + I E P+ + I GN VT GHL + + + Sbjct: 5 VIIVESPTKVKTITKY-------------TGNAYSVTATSGHLRDLPPHELGIDIDNGFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 K + +K + +A +I A DPDREG+ + V D L+ Sbjct: 52 PD----------YVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKK 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R + ++L +++ + + + AR D L G ++ Sbjct: 102 GR---RFHRVMFHELTKTGIQKGLTEPTELNR--NRYDAQQARRILDRLVGYQISPLLWR 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 RN LS GRVQ+ + ++ R+ EI F ++++ + A + RF A Sbjct: 157 KVRNG-----LSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + ++ A+ +V+ +S Q V K + PF+ S LQ EA Sbjct: 212 KGT------KNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAI 265 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G +A+ + + Q+LYE LITY R+D + E A + ++ Sbjct: 266 RKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSV--F 323 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D P R +K DAH AI PT S L++++ +Y LI ++ Sbjct: 324 GNDYAPDR-----PRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKR 378 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD----EENDGTPLP 465 ++ +A + I + + G+ L +E +++ G LP Sbjct: 379 FVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLP 438 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 + + + L + + + T PP F++A+L+ + +G+G Sbjct: 439 QLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEE-----------------NGIGRP 481 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQIS 582 +T A I+ + +G++ + T+ G + L E + TA+ E+ L +I Sbjct: 482 STYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIE 541 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF-----RGIVAPGSGGSADKKKAAPRKRS 637 Q + ++ G Q I+ AK G+ P G K Sbjct: 542 SDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFL 601 Query: 638 AKKSPPADE 646 A P + Sbjct: 602 ACSGYPDCK 610 Score = 43.1 bits (100), Expect = 0.040, Method: Composition-based stats. Identities = 5/44 (11%), Positives = 9/44 (20%) Query: 608 RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + G G K+ A + P + Sbjct: 627 EPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSL 670 >UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group RepID=A9VVE2_BACWK Length = 714 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 191/668 (28%), Positives = 310/668 (46%), Gaps = 44/668 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECG-----NGQVVTWCIGHLLEQAQPDAYDSR 57 L +AEKP+ A+A A+ PK ++ F +G +TW GHL+E P Y Sbjct: 4 LVLAEKPNQAKAYAEAFPKVEKREGHFYVPPCSLLPSGGNITWAYGHLVELKSPQDYKKE 63 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + +W+L+ LPI+P +++ + KQ N++K+ + EA V D DREG+ + ++ Sbjct: 64 WEKWDLSQLPILPSRYEYKVSADKKKQFNIVKKLMKEADTTVVDVDIDREGEAIARLIIQ 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++++R IN L +++ L+ +F + A AR +DW+ G+N + Sbjct: 124 EAGCTH---KKIKRLWINSLEVDEIKKGFQNLKPGEDFESMFEEAQARQLSDWIVGMNAS 180 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R YT+L R G QGV SVGR QTP L L+ +R +EI+NF FFE++A +P Sbjct: 181 RLYTLLLRQKGVQGVYSVGRCQTPALCLINKRQQEIKNFKPTPFFELEAQFTSPNGVYMG 240 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + +G L++ + S Q +V S K + + A FSLS++ Sbjct: 241 RY-------KERFTTKGELMNLLQQHSISEN-SSQQGMVKSVEVKPKQQEATKLFSLSSI 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q A K++ S +VL Q+LYE KL+TYPR+DC Y+ E F ++ A Sbjct: 293 QALANKKYKYSPADVLKGIQELYEA-KLVTYPRTDCNYITEGEFEYLKNNLSGYQSIASV 351 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA----INLTENEAKVYNLIARQYLMQ 413 + R D+KKV H+AI+ T + L + + +Y + + L Sbjct: 352 NFQPHSLT--ANKRYVDNKKVQEHYAIVLTKNVPSRETIARLPDKQRNLYMEVLKSVLSM 409 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP---LPVVAKG 470 F ++ + VI D+ F K + GW+ L + + +EE+D LPVV +G Sbjct: 410 FYAPYMYEETVITSDLNGLLFTTKGKAEKSLGWKELYVTDKIEEEDDQEKVSLLPVVKQG 469 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + + + E T PP+ +T+ L++ M V+D++ K IL+ +GLGTEATRAG Sbjct: 470 EFVQ-GLVKSKEGVTTPPKPYTEGQLITMMKTCGSSVEDEESKIILKEVEGLGTEATRAG 528 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQ 589 IIE L K+G++ K + T G+ L S+ M +P++TA WE L +I ++Q Sbjct: 529 IIETLKKQGYIEVKRNKVSVTPKGEILCESVQGTMLAKPELTAKWEGYLRKIGKEQGSKD 588 Query: 590 DFMQPLVGTLYQLIDQAKRTPVR------------QFRGIVAPGSGGSADKKKAAPRKRS 637 F+ + LI +A + + P G +K Sbjct: 589 IFVSQTSEFIKDLIKEATESIGELKIDNKIQDMKAKDTIGKCPKCGKDVVNRKT----FY 644 Query: 638 AKKSPPAD 645 Sbjct: 645 GCSGYKEG 652 >UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1ABE5_GEMAT Length = 816 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 133/688 (19%), Positives = 240/688 (34%), Gaps = 99/688 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + G V +GH+ + + Sbjct: 52 LVIVESPAKAKTIGKYLGR-------------GYTVKATVGHVRDLPAKKLGIDIDHGFA 98 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L +K+ A EI A DPDREG+ + V Y Sbjct: 99 PE----------YVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGWHVEQYFTQP 148 Query: 123 PEK--RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++R + +++ AV +++ + + AR D L G + Sbjct: 149 KRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKK--VEAQQARRVLDRLVGYKASPVL 206 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + LS GRVQT L L+V R+ EI F +++ + A + + FTA Sbjct: 207 WKTVKKG-----LSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQ-KGQQPFTAKL 260 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQI 299 + ++ + + AE ++ ++G + +VT + ++ PF+ S LQ Sbjct: 261 HQLDG------KKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQ 314 Query: 300 EAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EAAK+ G ++ + + Q LYE LITY R+D + E+ + A Sbjct: 315 EAAKKLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRA- 373 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 D L DAH + PT S LT ++ K+Y LI Sbjct: 374 -QFGDDFLA----PAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLI 428 Query: 407 ARQYLMQFCPDAVFRKCVIELDIA--------KGKFVAKARFLAEAGWRTLLGSKERDEE 458 ++++ AVF ++ +I F A + G+ L + + Sbjct: 429 WQRFMASQMAPAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGD 488 Query: 459 ----NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 D LPV+ + + + + T+PP F++A+L+ + Sbjct: 489 AKALEDEQALPVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAG---------- 538 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMT 571 +G +T A II +L +R +++ + R T G+ + + + T Sbjct: 539 -------IGRPSTYASIISVLVERRYVSLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFT 591 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQA-------KRTPVRQFRGIVAPGSGG 624 A E L +I+E + + + + ++ + + P GG Sbjct: 592 AQMEEELDKIAEGEIDWVRALGDFWTPFQRTLNDNDLDALIGEAYDLSALETERCPDCGG 651 Query: 625 SADKKKAAPRKRSAKKS-PPADEVGSGA 651 K A ++ P A + Sbjct: 652 KLVAKGGFFGPFVACENHPKACKYTRPI 679 >UniRef50_Q5NX65 Topoisomerase IA n=1 Tax=Aromatoleum aromaticum EbN1 RepID=Q5NX65_AZOSE Length = 634 Score = 521 bits (1343), Expect = e-146, Method: Composition-based stats. Identities = 228/620 (36%), Positives = 327/620 (52%), Gaps = 30/620 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPSL +AIA+ LP + DGFI G VVTW GH+LE A P+AY+ + Sbjct: 1 MRLYIAEKPSLGKAIAENLPGVKSRDDGFIRVGTD-VVTWAHGHILELAPPEAYNPAWKS 59 Query: 61 WNLAD--LPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 WN A LP E ++L P+P QL VI+ L +A+E+V+AGDPDREGQ+L+DE+L+ Sbjct: 60 WNTAVNVLPYPIECFKLLPKPDSKAQLRVIQSLLSQATEVVNAGDPDREGQMLIDEILES 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + R LIN +P V++A+ +R NSEF L +A R+ ADW+ G+N+T Sbjct: 120 SAW----KGPTLRLLINATDPVTVKKALSSMRPNSEFFNLYQAAKCRSEADWIIGMNLTV 175 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A T L ++SVGRVQTP L LVVRRDE IE F A+ FF ++ + TP Sbjct: 176 AATKLL---ANDELVSVGRVQTPTLALVVRRDEAIEKFGARPFFSLEVTLETPQG----- 227 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 P DE R+ A+ +V + + ++ + + ES P F L Q Sbjct: 228 ---PIVLTYNPSDESKRIWSEVDAKRIVEEVKQRQSVTVTVTTGIKKESPPRLFMLRTFQ 284 Query: 299 IEAAKRFGLSAQNVLDICQKLYET-HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 E R+G SA L++ Q LY++ H+L +YPR+DC Y+P + I Sbjct: 285 GECNSRYGWSASKALELAQSLYDSKHQLASYPRTDCEYMPAGQANDALTIAQHIVKQTSF 344 Query: 358 LLPQPVVDPD-IRNRCWDDKKVDAHHAIIPT-ARSSAINLTENEAKVYNLIARQYLMQFC 415 P++ R +D KV HHA+ PT + LT +E K + L+A ++LM Sbjct: 345 TAFAPLLSLAVPRASIYDSSKVTEHHALTPTVKSADFKTLTADEQKAWLLLAERFLMSLL 404 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAE--AGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 P + V+ + +F AK WR L PLP VA G L Sbjct: 405 PSHQIEETVVSFSHGEIEFSAKGEVSLNMAQSWRALAPHT-------YKPLPQVADGATL 457 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 VV+ +T PP+ +T+ TLL M+ +A++V+D LK IL+ T G+GT AT+A IIE Sbjct: 458 QMAGLRVVKGKTTPPKRYTEKTLLDDMSSVAKYVEDPKLKAILKETSGIGTAATQAKIIE 517 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L +RG++ K R + ST G+A+ H LPE T P +TA WE L I+ + D+M Sbjct: 518 TLKERGYVAVKNRELISTPFGRAVVHGLPERLTDPCLTALWEDALGLIAAGGMKPGDYML 577 Query: 594 PLVGTLYQLIDQAKRTPVRQ 613 + G QL+D + + ++ Sbjct: 578 RVRGMCKQLVDDVRDSVGKK 597 >UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E2F6_DICTD Length = 696 Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats. Identities = 140/671 (20%), Positives = 250/671 (37%), Gaps = 86/671 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I +L K + V GH+ + + + + Sbjct: 5 KLIIVESPAKAKTIEKILGKEFK-------------VLASYGHIRDLPEKELGVDIENNF 51 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + PS K ++ IK +A ++ A DPDREG+ + +++ L+L Sbjct: 52 KP----------KYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHLVEELKL 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 +++ R +++ P+A+ AI R + + AR D L G ++ Sbjct: 102 ---PKEKFTRIEFHEITPRAILEAIKNPREID--LDRVEAQQARRILDRLVGYELSPLLW 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 R LS GRVQ+ L + R+EEIE F+ ++++ + + Sbjct: 157 EKVRKG-----LSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEEKVLYG---- 207 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 Y+DEE + + ++ ++ + K E + P PF S LQ EA Sbjct: 208 ---KLILYKDEEVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEA 264 Query: 302 AKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +KRFG + I Q LYE LITY R+D + E + S Sbjct: 265 SKRFGFPVGKTMKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIE--SGF 322 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + + + + DAH AI PT+ LT+ + K+Y LI + Sbjct: 323 GKEYVGKEHKE------KKKLGVQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWER 376 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV-- 467 ++ A+F I + F++K + L AG+ +L KE + E Sbjct: 377 FIASQMNHAIFEVVEIYIKGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVP 436 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G + + T+PP +T+ATL+ + G+G +T Sbjct: 437 EEGKNVKLTTLIPRQFFTEPPPRYTEATLVRTLEK-----------------YGVGRPST 479 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEK 584 A IIE L +R ++ K R + T GK + L + TA E L +I Sbjct: 480 YATIIETLKERKYVEVKDRTLVPTTLGKVVNDFLTKQFPHLIDVKFTARMEEDLDKIESG 539 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVR----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 + + + ++ + +++ + + + + P G ++ K A Sbjct: 540 KVKAIEVLKKFYPAFKEELEKVSKNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACS 599 Query: 641 SPPADEVGSGA 651 P + Sbjct: 600 RYPECKYTKPI 610 >UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C6WSV7_METML Length = 864 Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats. Identities = 146/677 (21%), Positives = 258/677 (38%), Gaps = 84/677 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E PS A+ + L + V GH+ + + ++ Sbjct: 3 KLLIVESPSKAKTLKKYLG-------------SDFEVLASYGHVRDLIPKNGAVDTENQF 49 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + +K ++ I + + A I A DPDREG+ + + + L+ Sbjct: 50 AM----------KYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAISWHIAEILKS 99 Query: 122 APEKRQQVQ-RCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + ++ R + +++ AVE AI R S +P+ + AR D+L G N++ Sbjct: 100 KKLLKNKLMKRVVFHEITKGAVEHAIAEPRDIS--MPMVNAQQARRALDYLVGFNLSPLL 157 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 R LS GRVQ+P L L+V R+ EIE F +++++ + F A Sbjct: 158 WKKIRRG-----LSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLD-ALKHQHGFKAKL 211 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRI---SGQPAIVTSYNDKRESESAPLPFSLSAL 297 + E+ +++ +V ++ S V+ K+ S S PF+ S L Sbjct: 212 VQLNNQKV---EQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTL 268 Query: 298 QIEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q EA ++ G + + + Q+LYE T LITY R+D L E + Sbjct: 269 QQEAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVK- 327 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-----NLTENEAKVYNL 405 + LP+ V +++ +AH AI PT S L + + K+Y + Sbjct: 328 -KNFDTEYLPKSPVMYKTKSKS----AQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEM 382 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKG--KFVAKARFLAEAGWRTLL-GSKERDEENDGT 462 I ++ L A F ++L + F A + L G+ + + +EE + Sbjct: 383 IWKRALACQMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAES 442 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + G+ L EK + T+PP +++A+L+ + G+ Sbjct: 443 KLPNLETGEILTVEKIYGEQHFTEPPPRYSEASLVKVLEE-----------------YGI 485 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A II L R ++ + TD G+ + L E D TA+ E+ L Sbjct: 486 GRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALD 545 Query: 580 QISEKQCRYQDFMQPLVGTLYQLI-DQAK-RTPVRQFRGIVAPGSGGSADKKKAAPRKRS 637 ++E + + M Q I ++A P + P G K+ + Sbjct: 546 SVAEGERDWVPLMDEFWQDFNQQIHNKADVERPGNELIDEACPKCGKPLQKQLSRFGSFI 605 Query: 638 AKKSP---PADEVGSGA 651 P + Sbjct: 606 GCTGYNDTPKCDYKRSI 622 >UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FFH7_FLAJ1 Length = 689 Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats. Identities = 192/657 (29%), Positives = 304/657 (46%), Gaps = 42/657 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M++ IAEKPS AR IA +L +K DG++ GNG VTW +GHL+ P+ Y Sbjct: 1 MKVVIAEKPSAAREIAVLLGANEKK-DGYL-AGNGYFVTWALGHLVGLGLPEDYG--IKG 56 Query: 61 WNLADLPIVPEKWQLQPRPSV-----------TKQLNVIKRFLHEASEIVHAGDPDREGQ 109 + + LPI+P+ + L R KQL IK + + I+ A D REG+ Sbjct: 57 FEKSSLPILPDPFLLTVRKQKIDAGYTADAGAQKQLKTIKYVVGLSDLIIVATDAGREGE 116 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 L+ + +YL E R+ R I++L +A+ + ++ L+ SE L ++A AR+RAD Sbjct: 117 LIFRYIYEYL----EFRKPFVRLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSRAD 172 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL GIN ++A ++ A GV S+GRVQTP L LV R E ++F + +++++ Sbjct: 173 WLVGINASQALSL----AQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQLQLTHS 228 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 FT+I + + + R + R A A V+S K +E P Sbjct: 229 R-NFMLFTSISEKRWDNKRQAMDALRAIERNAA----------TAWVSSVEIKNSTEQPP 277 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L F L+ LQ +A+ LSA L I Q LYE I+YPR+ R + + + +++ Sbjct: 278 LLFDLTGLQKQASTDLSLSAGETLSIAQSLYEKQ-FISYPRTGSRSISADVWDEIPSLIK 336 Query: 350 AISVHAPDLLPQPVVDPDI-RNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 A+ + R + V HH ++PT R + L+ E +YNLIA Sbjct: 337 ALGTRENFREAISTLKLGRLNKRIVSEAGVTDHHGLLPTERIPSA-LSGKETAIYNLIAG 395 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + L + + L + F+ + E+GWR + E G LP + Sbjct: 396 RLLEAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWRGVKARFLESGEP-GQELPEIK 454 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +GDEL ++ V+E+ T PP +T+A LLS M + QD +KIL G+GT ATR Sbjct: 455 RGDELKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQERKIL-QAIGIGTPATR 513 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISEKQCR 587 A IIE LF R ++ ++G+ + T+ G ++ + + MTA WE+ L +I K+ Sbjct: 514 AAIIETLFDRKYIQRQGKSLIPTEKGLMVYELVKDKRIADVAMTAQWETELWKIENKEAD 573 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPV--RQFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 F + + + + TP + P + K K+ Sbjct: 574 AATFQKQMESYATSITKELLETPRPHDMVPDLCCPRCNINRLLITENMVKCPEKECR 630 >UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID=TOP1_RICBR Length = 800 Score = 520 bits (1339), Expect = e-146, Method: Composition-based stats. Identities = 130/691 (18%), Positives = 253/691 (36%), Gaps = 94/691 (13%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I E P+ A+ I L + V GH+ + Sbjct: 1 MKLVIVESPAKAKTINKYLG-------------DEFKVIASFGHIRDLPSKKGSVIPDEN 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 +++ + K ++ I + +A + A DPDREG+ + + + ++ Sbjct: 48 FSM----------KYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIAEVIK 97 Query: 121 LAPEKRQQ--VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + +R N++ +A+ AI+ R L + AR D+L G ++ Sbjct: 98 EKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDN--NLVNAQQARRALDYLVGFTLSP 155 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 G S GRVQ+ L L+ R++EIE F +++++++ ++ +E FTA Sbjct: 156 LLWRKL-----PGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E+ + + A+ + ++ Q V K++ PF S+LQ Sbjct: 211 KLTHINDQKL---EKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EAA++ G SA+ + I QKLY ET LITY R+D L + ++N Sbjct: 268 QEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLIN-- 325 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS-----SAINLTENEAKVYNLI 406 D + + + +AH AI PT + L ++ K+Y LI Sbjct: 326 ----KDYGDKYLPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELI 381 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKF--VAKARFLAEAGWRTLLGSKERDE-ENDGTP 463 ++ + + + L ++ A +A G+ + DE E + Sbjct: 382 WKRTIACQMENVIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKM 441 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + + L ++ + T+PP +++A+L+ + + +G Sbjct: 442 LPPLKEQEHLKTKEIIPNQHFTEPPPRYSEASLVKKLEELG-----------------IG 484 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQ 580 +T A I+ +L R ++T + + + G+ + L D TA E+ L + Sbjct: 485 RPSTYATILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDE 544 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV-----------------RQFRGIVAPGSG 623 I+ + ++ + I+ + + V P Sbjct: 545 IAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYVQQALDYHIFGENKDSKVCPSCK 604 Query: 624 -GSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 G K A + P ++ Sbjct: 605 TGELSLKLGKFGAFLACSNYPECNFRKSIVS 635 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 519 bits (1338), Expect = e-146, Method: Composition-based stats. Identities = 156/695 (22%), Positives = 260/695 (37%), Gaps = 98/695 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ A++I L K G V GH+ + D Sbjct: 1 MYVVIVESPAKAKSINKYLGK-------------GYEVYPSYGHVRDLPAKDGSVD---- 43 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 P K+LN I R + +A +I+ A DPDREG+ + VL+ L+ Sbjct: 44 ------PDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLK 97 Query: 121 LAPEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + N + AV A+ R V L + LAR D+L G N++ Sbjct: 98 AKKVLKDKPVERVVFNAITKSAVLEAMQHPRQID--VALVDAYLARRALDYLVGFNLSPV 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 G S GRVQ+ L LV R+ EIE FVA++++ + AH+ T AD FTA Sbjct: 156 LWRKL-----PGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTAR 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ + + A + V K PF+ S LQ Sbjct: 211 LVGADGKKI---TRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 EA+++ G + + + Q+LY ET LITY R+D L E +V+ Sbjct: 268 EASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIAR-- 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 +P+ ++ + +AH AI PT + L ++AK+Y LI Sbjct: 326 QFGDAYVPKAPRKYTVKAK----NAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIW 381 Query: 408 RQYLMQFCPDAVFRKCVIELD----IAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 + + A + ++++ K A + + G+ L DE++D + Sbjct: 382 TRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESA 441 Query: 464 -LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP +AK + L E+ E + T+PP FT+ATL+ M + + Sbjct: 442 RLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEELG-----------------I 484 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLT 579 G +T A + +L +R ++ + + +H D G+ + L R D TA E L Sbjct: 485 GRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARYVGYDFTADLEEKLD 544 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------------------A 619 ++S + ++ ++ + K + + Sbjct: 545 RVSNHEIDWKQVLRDFWLDFSGALAGTKDLRTTEVLDRLNEILGPHIFPPKEDGSDPRGC 604 Query: 620 PGSG-GSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 P G G K + P + A Sbjct: 605 PSCGEGKLSLKLGKFGAFIGCSNYPECKFTRTLAA 639 >UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotuberculosis IP 31758 RepID=A7FCC2_YERP3 Length = 815 Score = 519 bits (1336), Expect = e-145, Method: Composition-based stats. Identities = 185/670 (27%), Positives = 310/670 (46%), Gaps = 46/670 (6%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+A IA L +K D F E + +++ IGHL+E + + Sbjct: 6 LIIAEKPSVAFDIAKALGG-FQKKDNFFES-DRIIISNGIGHLVEVYSTEMDAEGTK--D 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L+ LP++P +Q++P+P Q N++K+ ++ +++A D REG+L+ + + + Sbjct: 62 LSALPVIPSHFQVKPKPKTISQFNLLKKLMNRPDVGSVINACDAGREGELIFRLIYEAIG 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 R+ ++R I + P A+ A + ++ + + +A R D++ GIN +RA Sbjct: 122 ----SRKPMKRMWIKSMTPTAIREAYENIKDGRFYDRVDDAARCRTEGDFIVGINASRAI 177 Query: 181 TIL-GRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T R +L+ GRVQTPVL ++ +R++EI +FV + F+EV A + E + Sbjct: 178 TAFKSRQERSFQMLAAGRVQTPVLSMITQREDEIRSFVQRTFWEVMATFTLASGE-YNGR 236 Query: 240 WQPSEACEPYQDEEG-RLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 W P+++ Q+ +G R + A+ ++++ G + K P F+ +ALQ Sbjct: 237 WIPAKSTNSNQESDGSRFFDQSAAKAILDKCRGVEPTSVTEVSKITKSHPPKLFNQTALQ 296 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI-----SV 353 IEA KR+ SA+ LD+ Q LYE HK+++YPR+ LPE++ ++M + Sbjct: 297 IEANKRYKFSAKKTLDLTQALYEKHKMVSYPRTSSTALPEDYGDTVLSIMTHLFTGSEYE 356 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQYL 411 + +D+ ++ H AIIP ++ + LT +E K+Y+LI R+++ Sbjct: 357 KYAAYVTTHNRIDPSNKTIFDNDEISDHFAIIPAIGSQCNVAGLTPDELKIYDLIVRRFI 416 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A + +A+ F R L E GW+ ++ + N L + +G+ Sbjct: 417 AAFYPVATYSATERLTIVAEESFKTTGRVLLETGWQAVIKQPTDNATNS---LCALKEGE 473 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + T PP F ATLL+AM + V D DL K ++ GLGT+ATRAGI Sbjct: 474 TAGNKVMGLKTGNTTPPSRFNVATLLAAMQTAGKLVDDDDLAKAMKGC-GLGTDATRAGI 532 Query: 532 IELLFKRG---------FLTKKGRY--IHSTDAGKALFHSLPE----MATRPDMTAHWES 576 IE L ++ +G+ T L L + M T P MT WE Sbjct: 533 IEGLLSNKTAAGNAKEPYIVIEGKEQLFVPTPKAMDLISFLRDNNVLMLTNPTMTGEWEQ 592 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAK-------RTPVRQFRGIVAPGSGGSADKK 629 L+ + + Q FM + Q+ID K P R F G P + Sbjct: 593 KLSLMEHGKYNRQTFMAEIAENTRQMIDTIKVRASEIPAEPHRDFAGAKCPKCPSALIST 652 Query: 630 KAAPRKRSAK 639 + + Sbjct: 653 QRTVTCSAEC 662 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 515 bits (1327), Expect = e-144, Method: Composition-based stats. Identities = 138/672 (20%), Positives = 251/672 (37%), Gaps = 86/672 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I +L + V +GHL + Q + Sbjct: 33 HLIIVESPAKAKTIERILG-------------SDYKVLASMGHLRDLPQRTLGVDVANDF 79 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + +++ +++ +I+ A DPDREG+ + + L + Sbjct: 80 KPE----------YVSSAERADVIENLQKEANKSKDILLATDPDREGEAISWHLSKLLDV 129 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 P R +++ P A++ A+ + + AR D L G ++ Sbjct: 130 DPRSNA---RIAFHEITPPAIKEAVLHPEPID--LNRVDAQQARRVLDRLVGYKLSPWLW 184 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 LS GRVQ+ L+ R+EEI F +++ V+ T E F A Sbjct: 185 KQI-----YRGLSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLT 239 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + +E ++ + A+ VV I QPA +TS ++ A P++ S +Q +A Sbjct: 240 QVDG------KEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKPPYTTSTMQQDA 293 Query: 302 AKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 R ++ + + Q LYE LITY R+D + +E + + Sbjct: 294 VNRLNFGSKKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIERV-- 351 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 + D LP P DAH AI PT A + L+ ++ ++Y LI Sbjct: 352 YGKDYLP-----PKPNVYARGKDSQDAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWN 406 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVV 467 ++L + + L A + G+ L KE+ ++N+ LP + Sbjct: 407 RFLASQMAPQISQATNAVLQSGIYTLRATGTQILFDGFTVLRTVKEKKQDNEELPILPAL 466 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 KG +L K E + T PP +T+A+L+ + G+G +T Sbjct: 467 HKGHTVLNTKAEGEQHFTAPPPRYTEASLIKTLEE-----------------KGIGRPST 509 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEK 584 A I++ + +R ++ K+G+ TD G + L + D TA E+ L +I++ Sbjct: 510 YAPILDTIQRRKYVEKEGKQFVPTDIGFKVTDLLKKYFAGIVSVDFTAQLETWLDKIADG 569 Query: 585 QCRYQDFMQPLVGTLYQLIDQAK------RTPVRQFRGIVAPGSGGSADKKKAAPRKRSA 638 + Y+ M + + A + ++ ++ G K + K A Sbjct: 570 KATYKKVMSGFWDVFEKELQNANLEAAKAKEENQEVSDVICEKCGAHMIVKMSRYGKYLA 629 Query: 639 KKSPPADEVGSG 650 + P+ + Sbjct: 630 CPNFPSCKNIKP 641 >UniRef50_D0Z5F5 DNA topoisomerase n=1 Tax=Photobacterium damselae subsp. damselae CIP 102761 RepID=D0Z5F5_LISDA Length = 727 Score = 515 bits (1326), Expect = e-144, Method: Composition-based stats. Identities = 209/670 (31%), Positives = 330/670 (49%), Gaps = 38/670 (5%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MRLFIAEKPSLA+AI + L ++ G+ E GN +VTWC+GHLLEQ+ P+ Sbjct: 1 MRLFIAEKPSLAKAIFEGLGGNPKTQRKQGYFENGND-IVTWCVGHLLEQSPPEH----- 54 Query: 59 ARWNLADLPIVPEKW-QLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +W L LPI E +++P Q V++ + +A IV+A DPD EG LL DE+L Sbjct: 55 -QWKLEYLPIKSEYPPKMRPIEKTKDQFKVVQDLIKKADSIVNASDPDEEGNLLCDEILT 113 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + V+R L+ DLN + V+RA+ ++ N F SALAR+ D ++G NM+ Sbjct: 114 YCH----NTKPVERLLVADLNLEPVKRALANMQPNENFHGWTQSALARSIGDLIFGFNMS 169 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +AYT+ R GY G +GRVQT LG++ R ++ F++V A ++ Sbjct: 170 QAYTLKAREMGYSGTFGIGRVQTVALGMINERTLANQSHQESYFYQVYADFAF-NNQTVK 228 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + P+ E DE+ RLL + A+ + Q A++ K P P+ LS+L Sbjct: 229 ARYLPTTNNEV--DEQNRLLSKTEAKQIAQATDNQHALIIDAQTKPTKSLPPRPYDLSSL 286 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q AK++G SA+ LDICQ LYE HK++TYPR+D R+L + H R A+ I+ P+ Sbjct: 287 QQLCAKKWGYSAKKTLDICQSLYEKHKVLTYPRTDNRFLGDSHLEQRVAIFKNIAEAIPE 346 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLMQFC 415 L D +++ +D K+ AHHAI+PT S+ LT++E +Y +AR ++ F Sbjct: 347 LSSMVANADLSLKHHAFDASKITAHHAIVPTLTSAKGLTLTKDEQTIYEFVARSFIALFY 406 Query: 416 PDAVFRKCVIELD-IAKGKFVAKARFLAEAGWRTLLGSKERDEEN-DGTPLPVVAKGDEL 473 P +V + + ++ K +F A L+ GW L E+ +G L + + E Sbjct: 407 PASVRDRTEVTIELANKYRFKANQTQLSVVGWEVLYKDDIEAEKPIEGVDLTTLKRDQET 466 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA--------TDGLGTE 525 + + +T+PP++ +A+L++ M + ++D +L+ A +GTE Sbjct: 467 KASNPTIEKGKTKPPKYHDEASLIAFMKKAGKLIKDPELRAKFEAKDKGDRDNCGSIGTE 526 Query: 526 ATRAGIIELLFKRGFLTK-------KGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVL 578 ATRA I++ + R L + K + +T G+ LP T PD++A W Sbjct: 527 ATRANILDTVKSRSDLVQVVKMKGYKQKVWITTPLGQEFCAMLPSEFTAPDISAIWSQHQ 586 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-FRGIVAPGSG-GSADKKKAAPRKR 636 I + F+ L G + +D+ K V P G K+ + Sbjct: 587 LAIKNGDMTVEQFLDELDGFVAHYVDKVKTNGVNITVETFDCPNCADGHLIKRNGSKGVF 646 Query: 637 SAKKSPPADE 646 + P + Sbjct: 647 WSCNRYPECK 656 >UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID=D1B6D6_THEAS Length = 708 Score = 514 bits (1325), Expect = e-144, Method: Composition-based stats. Identities = 132/669 (19%), Positives = 245/669 (36%), Gaps = 90/669 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A++++ +L G V +GH+++ + + Sbjct: 45 LVVVESPTKAKSLSKMLG-------------PGYAVEASLGHVMDLPKVRLGVDVENGFE 91 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + +K AS ++ A DPDREG+ + + L + Sbjct: 92 PE----------YIQVRGKGPVIKRLKELARGASRVLLASDPDREGEAIAWHLATLLGVP 141 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R I+++ P + A+ + + + AR D L G ++ Sbjct: 142 LDSPC---RVRIHEITPSGISAALQEVEGID--MNKVYAQQARRVLDRLVGYRLSPLLWA 196 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LV R++EI++FV ++++ V+ + Sbjct: 197 KVQRG-----LSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDK 251 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 RL + A V + P V+S+ + PF S LQ EA+ Sbjct: 252 EAGKPV------RLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEAS 305 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 +R G + + I Q L+E LITY R+D + +E + + S Sbjct: 306 RRLGYGPRRTMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHI--ASRF 363 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P LP+ + R DAH AI PT + + L+ + ++Y+LI R+ Sbjct: 364 GPMYLPERPNHFAQKGRS-----QDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRR 418 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 L DA R +E + F + GW + +D E +P ++ Sbjct: 419 ALASQMADARVRTNTLEARCGELTFKCSGVEVTFQGWGAVWPLGVKDTE-----VPAASE 473 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G++L + + ++ TQPP +T+A L+ A+ G+G +T A Sbjct: 474 GEDLRPLQVRLEQKFTQPPGRYTEAGLIKALEE-----------------KGIGRPSTYA 516 Query: 530 GIIELLFKRGFLTK-KGRYIHSTDAGKALFHSLPEMATR---PDMTAHWESVLTQISEKQ 585 I+E L RG++ + + + T G+ + L D TA E L ++ + Sbjct: 517 TIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLVTHFPDVVQVDFTARMEDQLDRVESGE 576 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++++ + G + + + R + G P G ++ + Sbjct: 577 IQWREPIGDFYGPFESRLQEVAASAQRMTVPPELAGEDCPQCGRPLLIRRGRYGEFIGCS 636 Query: 641 SPPADEVGS 649 P + Sbjct: 637 GYPECDFTK 645 >UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B3EPW7_CHLPB Length = 804 Score = 514 bits (1325), Expect = e-144, Method: Composition-based stats. Identities = 135/683 (19%), Positives = 249/683 (36%), Gaps = 98/683 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E PS A+ I L + +V +GH+ + + + + Sbjct: 15 LIVVESPSKAKTINKYLG-------------SDYLVFASVGHIKDLPKKEIGLDFDNNYE 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + K + +K+ +A++I+ A DPDREG+ + + + + A Sbjct: 62 P----------RYEVISGKEKVVRQLKKLAGQANDILIATDPDREGEAIAWHIANEVDAA 111 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ V R L N++ +A+ AI+ L S R D + G ++ Sbjct: 112 ---QKPVHRVLFNEITKKAILEAINDPLQID--YRLVRSQQTRQGLDKIVGYKISPFLWN 166 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L L+ R+ EI+ F K+++ + A T + E F+ Sbjct: 167 VVMRG-----LSAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFTTGSGETFSTKLVR 221 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 ++ + + ++ AE + I + V + + P PF+ S LQ A+ Sbjct: 222 IDSN------KAEITNQSDAEKTASDILSRIYGVAEITPRVQQRKPPFPFTTSLLQQAAS 275 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + G ++ + + Q+LYE LITY R+D + E + Sbjct: 276 NQLGFGSKKTMRVAQQLYEGIDLGPEGATGLITYMRTDSTRVSGEAVEQAERFI--TQHF 333 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 P+ + K DAH AI PT L+ ++ K+Y LI ++ Sbjct: 334 GPEF------TGGGQAAKKGKKTQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELIWKR 387 Query: 410 YLMQFCPDAVFRKCVIELDI--AKGKFVAKARFLAEAGWRTLLGSK------------ER 455 +L A + +++ + F A + G+ + + E Sbjct: 388 FLASRMAPAKIEQTRVDVADHEKQFIFRASGSNVLFPGFLKVYNEQKELDYEARKSTRED 447 Query: 456 DEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 +E+ LP + ++L + + + T+PP FT+A+L+ + Sbjct: 448 EEKEQIVKLPRNLTVNEKLTLDTLDKKQSFTRPPARFTEASLVKELDN------------ 495 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMT 571 G+G +T AGI L R ++ + + I T+ GK + L T Sbjct: 496 -----YGIGRPSTYAGIFSTLQDRRYVELEKKKIIPTELGKDVSMILVANFPDLFNVTFT 550 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGIVAPGSGGS-ADK 628 AH E+ L +I+ Y+ + L + K P+ + G Sbjct: 551 AHMENELDKIAAGDDEYEQVLDSFYKPLESALSVRKNDPLLPQNTDAETCDKCGKGKMII 610 Query: 629 KKAAPRKRSAKKSPPADEVGSGA 651 K A K S PA + Sbjct: 611 KWTASGKFLGCSSYPACKNIKPL 633 >UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMY2_9BACT Length = 782 Score = 513 bits (1322), Expect = e-144, Method: Composition-based stats. Identities = 138/666 (20%), Positives = 249/666 (37%), Gaps = 80/666 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I L + + V +GH+ + + Sbjct: 5 LVIVESPAKARTIEKYLGRNFK-------------VLASVGHVKDLPASSLGVDLDNDFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + K ++ +K+ + A I A DPDREG+ + + + L Sbjct: 52 P----------KYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIAWHIAEELG-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + + ++ R L N++ + +E I +E + AR D L G ++ Sbjct: 100 KKNKGKIYRVLFNEITKKGIEDGIKNTGPINE--NRTNAQQARRILDRLVGYLVSPLLWK 157 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L L+V R+EEIE F ++++ + A + Sbjct: 158 SLKYG-----LSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLEK 212 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 ++ R+ + AE V+ + V K E APLPF S LQ EAA Sbjct: 213 KNG------KKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAA 266 Query: 303 KRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ SA+ + + Q+LYE LITY R+D + + + + Sbjct: 267 RKLSFSAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIE--KQY 324 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + L + V + DAH AI PT+ + L ++ K+Y LI + Sbjct: 325 GKEFLSKGVKGGSKKKNV-----QDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDR 379 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVA 468 ++ DAV+ + I + ++ + + G++TL + +E D + V Sbjct: 380 FVSSNMADAVYDQNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVK 439 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L EK + + TQPP +++ATL+ + +G+G +T Sbjct: 440 EGETLNPEKHDSKQMFTQPPARYSEATLVKTLE-----------------AEGIGRPSTY 482 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEKQ 585 A II L R + + + T+ G+ + L + P TA E L + + Sbjct: 483 ASIISTLIDREYANMEEKRFKPTELGRVVCSLLIANFDRIFEPKFTAGMEEDLDSVEAGE 542 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI-VAPGSGGSADKKKAAPRKRSAKKSPPA 644 ++ ++ +++A++ + P K A S P Sbjct: 543 LTWKGVLRDFYAKFKPELEKAEKQFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYPE 602 Query: 645 DEVGSG 650 + S Sbjct: 603 CKFTSN 608 Score = 44.6 bits (104), Expect = 0.012, Method: Composition-based stats. Identities = 12/86 (13%), Positives = 19/86 (22%), Gaps = 24/86 (27%) Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 D TA+ E + + D+ + G Sbjct: 710 DCDFTANMEVN----EQGD-------------IIPKYDKVDEN-------VKCEKCGKPM 745 Query: 627 DKKKAAPRKRSAKKSPPADEVGSGAI 652 KK+ K A P + I Sbjct: 746 VLKKSRRGKFFACTGYPECKNAKSTI 771 >UniRef50_B2UQJ6 DNA topoisomerase III n=2 Tax=Verrucomicrobiaceae RepID=B2UQJ6_AKKM8 Length = 869 Score = 513 bits (1322), Expect = e-144, Method: Composition-based stats. Identities = 192/666 (28%), Positives = 314/666 (47%), Gaps = 40/666 (6%) Query: 3 LFIAEKPSLARAIADVLPK----PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 L IAEKPS+A +A VL K R G + ++T +GHLLEQ +P + + Sbjct: 5 LIIAEKPSVATDLARVLGKELGKFTRDKSGAFYQNDRAIITSAVGHLLEQKKPMTEEGKS 64 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVL 116 W LP++P K++L+P +L + + + +EIV+A D REG+L+ + Sbjct: 65 LPWKFDYLPVIPRKFELEPIKQSEDRLKKVLQLARSKDVTEIVNACDAGREGELIFHNLA 124 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y + + +R + + +A+ A +RS ++ PL +A+ R+ +DWL G+N Sbjct: 125 RYGKWT----KPTRRLWMQSMTDEAILNAWHGMRSEADMKPLTNAAVCRSESDWLVGLNS 180 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA TIL ++ G V GRVQTP L ++ +R+ EI+ F + + EV A + + Sbjct: 181 TRALTIL-QSRGGFNVTPAGRVQTPTLAILTQRELEIQAFEPEPYSEVWAEFDVQSG-SY 238 Query: 237 TAIWQPSE--ACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + W + + R+ A + +R G+ VT K + APL + L Sbjct: 239 SGRWIDRDWKKNDHPHSRAERIWDPEQAAVIRDRCRGKAGTVTE-EKKPVTTVAPLLYDL 297 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++LQ EAA R+G SA+ L + Q+ YE HK++TYPR+D RYLPE++ + ++ ++ Sbjct: 298 TSLQREAANRYGFSAKRTLQLAQECYEKHKVLTYPRTDSRYLPEDYLGKVYGIVGTVAEQ 357 Query: 355 APDLLP-----QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQ 409 P+ P R +D KKV H AIIPT + LT + K++ ++ + Sbjct: 358 NPEFAPFARDILDNKRIKPNRRVFDTKKVSDHFAIIPTGKM--EKLTGDAQKLFEMVMAR 415 Query: 410 YLMQFCPDAVFR---KCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +L F P AVF + + F+ R L E GW+ + G K + L Sbjct: 416 FLAVFFPAAVFEDTRRTTLITHQDGVTDAFLTTGRVLVEPGWQAVYGRKAGTSSKEE--L 473 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 V G++ + E+ T+PP + +ATLL+AM G + V D++L + + GLGT Sbjct: 474 VPVRDGEQAALREIEIRNAMTKPPARYNEATLLAAMEGAGKLVHDEELAAAM-SERGLGT 532 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP----EMATRPDMTAHWESVLTQ 580 ATRA IIE L + ++ + GR + +T G L L + T P +T WE L Q Sbjct: 533 PATRASIIEGLISQEYIVRDGRELLATRRGIELIALLERIGLKTLTSPSLTGEWEYKLKQ 592 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV------APGSGGSADKKKAAPR 634 + + FM+ + +++ + K Q + + P K Sbjct: 593 MEQAALPRDSFMEGIKTLTGEIVKRVKDFREAQQQVELPEMELDCPSCHAHGLKNTLDAV 652 Query: 635 KRSAKK 640 + K Sbjct: 653 SCRSCK 658 >UniRef50_A6G6C2 DNA topoisomerase n=2 Tax=Bacteria RepID=A6G6C2_9DELT Length = 1409 Score = 513 bits (1321), Expect = e-144, Method: Composition-based stats. Identities = 201/678 (29%), Positives = 329/678 (48%), Gaps = 53/678 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 + +AEKPS+AR IA L R+ G++E G G VTW +GHL+ A+P D+ + W+ Sbjct: 4 VVVAEKPSVARDIAAALGATQRRK-GYLE-GEGYRVTWAVGHLVGLAEPGDIDAAWKYWD 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRF--LHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 LA LP++P W L+ QL V+ R E+V A D REG+L+ + + + Sbjct: 62 LATLPMLPRSWPLRALEHGADQLAVLARLMNARGVKELVSATDAGREGELIFRYIYEQVG 121 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + +R I+ L +A+ RLRS ++ L +A AR+RADWL G+N++RAY Sbjct: 122 CT----KPWRRLWISALTHEAIRAGFRRLRSPAQLEGLANAARARSRADWLVGMNLSRAY 177 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 ++ + LSVGRVQTP L ++V R+ I FV + + EV A E Sbjct: 178 SLR-----HDDSLSVGRVQTPTLAMLVERERAIREFVPELYREVHARFGASVGEYEGVYH 232 Query: 241 QPSEACEPYQDEEGRLLHRP----------------LAEHVVNRISGQPAIVTSYNDKRE 284 +P+ Q + R AE V+ R A V S + + Sbjct: 233 RPAPPDSETQAQRAAKPRRDAKAAANTLARLPAEPDEAEEVIARAKRGEAHVASVSRTKR 292 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 S PL + L+ LQ A + FG SA+ LDI Q LYE HK ++YPR+D R++ E Sbjct: 293 SFPPPLLYDLTELQRHANRLFGFSAKRTLDIAQTLYERHKALSYPRTDSRHIDRETAGTL 352 Query: 345 HAVMNAISVHAP----DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA 400 +++ AI+ +L+ + + + +R +D KV HHAI+PTA ++ +EA Sbjct: 353 GSIVAAIAPSYSGAETNLVAERSGERPLGSRYVNDAKVSDHHAILPTAERPSLRAGSDEA 412 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAK-----------GKFVAKARFLAEAGWRTL 449 K+Y+L+ R+ L + + + +E I ++++ + + GW + Sbjct: 413 KIYDLVCRRLLAAYHEPHIEARTKVETHIVTARPEAGVEAIVDRYLSTGSSVEQEGW-KV 471 Query: 450 LGSKERDEENDGTPLP-VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 L + R + LP +AK + + +QTQPPR ++ATLL AM R + Sbjct: 472 LDLRVRPKAKTEPKLPGGLAKDQAVRVLDVRALSKQTQPPRPHSEATLLGAMEHAGRQLD 531 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKG-RYIHSTDAGKALFHSLPEMATR 567 D+ L + +R + GLGT ATRA IELL +RG++ ++G + + ++ G+ L ++ Sbjct: 532 DEQLGEAMRGS-GLGTPATRAATIELLLRRGYVEREGSKALRASPKGERLIDAVHPQVKS 590 Query: 568 PDMTAHWESVLTQISEKQC-RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSA 626 P+MT +WE L Q+ + + FMQ + + ++ + R P G + Sbjct: 591 PEMTGNWELSLHQM-RGEAGELEAFMQTIERYVSEVCAAVQAQGRAPPRS---PRPGPAR 646 Query: 627 DKKKAAPRKRSAKKSPPA 644 + + + R+ + PA Sbjct: 647 AQHEPSDRRAHPGQPGPA 664 >UniRef50_Q3BZV2 DNA topoisomerase n=1 Tax=Xanthomonas campestris pv. vesicatoria str. 85-10 RepID=Q3BZV2_XANC5 Length = 728 Score = 513 bits (1321), Expect = e-143, Method: Composition-based stats. Identities = 224/701 (31%), Positives = 356/701 (50%), Gaps = 57/701 (8%) Query: 2 RLFIAEKPSLARAIADVL--PKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 +L++AEKPS+ +A+A L P G G+ V W GH+ + A+PD Y R Sbjct: 5 KLYVAEKPSVGKALAGHLAKSAPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERTY 64 Query: 60 R-----------WNLADLPIVP--EKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDR 106 W LP++P ++W+L P + ++ +++ L A+ +VHAGD DR Sbjct: 65 PEAKRGANGRFPWLFDHLPLLPANDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDR 124 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EGQLLVDEVL+ L+ R V+R L ++ +V+R + R N +F + +A+AR Sbjct: 125 EGQLLVDEVLEDLRC----RVPVKRVLPKAIDDVSVQRVLADERDNRDFARMRDAAIARG 180 Query: 167 RADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 RADWL G+N +R T+ R AG G +S+GRVQTPVLGL+ R+ EI NF D+ + A Sbjct: 181 RADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTA 240 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 I A +F A W+P +P DE GRLL +A V +++G+ + Y D++++E Sbjct: 241 MIAVQAG-KFRAKWRPRNG-QPGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNE 298 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 +APLPFSL LQ A++R+G+ + L + Q LY++ KL+TYPR+DC YLP A Sbjct: 299 NAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAE 357 Query: 347 VMNAISVHAPDL---LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKV 402 ++ A+ +D ++R +DDK+V AHH I+PT +++ + L+ E + Sbjct: 358 IVQAVREGFRGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSREERLI 417 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE-------- 454 Y IAR+YL QF P +RK + ++A F+A R + GW+ L G E Sbjct: 418 YEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADDDAA 477 Query: 455 RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK- 513 ++ D LP + + + CE + ++T+PP FTD TLL AM I ++V +K Sbjct: 478 PQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKA 537 Query: 514 ---KILRATD----------GLGTEATRAGIIELLFKRGFLT-----KKGRYIHSTDAGK 555 +L+ ++ G+GT ATR L + G + KK ++ T AG Sbjct: 538 HFVAMLKKSEAGADDQAQGCGIGTPATRHTFAPKLIEIGVVEHIAGKKKAKFFAPTAAGL 597 Query: 556 ALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-- 613 AL+ +LP T PD TA W+ +I + + FM + ++ + ++ + Sbjct: 598 ALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINAMLAEIRQLRIVLPD 657 Query: 614 --FRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 R + + G +K + P ++ G + Sbjct: 658 LGPRRVPPTKTAGKRKTASKGGKKANGGSGAPCEKCAKGTM 698 >UniRef50_C9M9A9 DNA topoisomerase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9A9_9BACT Length = 645 Score = 513 bits (1321), Expect = e-143, Method: Composition-based stats. Identities = 236/620 (38%), Positives = 354/620 (57%), Gaps = 23/620 (3%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRL+IAEKPS+AR +A L ++G I+ NG +V W GHLLEQA+P AY ++AR Sbjct: 1 MRLYIAEKPSVARLLAATLGDGKQEGQ-HIKLTNGDIVAWAAGHLLEQAEPAAYGDQWAR 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WN+ LPI+P++W++ R V I+ L +A+E+V+ GD DREGQLL+DE+L + Sbjct: 60 WNIDSLPILPQQWKMNVRSEVKDLFKSIQGDLKDATEVVNVGDADREGQLLIDEILQRCR 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V+R LI D + A+ + N +A AR+RADWL+G+N TRA+ Sbjct: 120 ----YKGPVKRLLITDTTETGIRNALASMTPNEAHRGAAQAAQARSRADWLHGMNGTRAF 175 Query: 181 TILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T L + GY+G L +GRV+TPV LVVRRD EIE+FV K ++ +KA + P+ ++A+ Sbjct: 176 TCLAQKGGYRGNALRIGRVKTPVTALVVRRDLEIEHFVPKPYWVLKAQVSVPSG-TYSAV 234 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W+P+E D++ RL+ + + +V R++G A V S K PL +SL LQI Sbjct: 235 WKPTEDQVGL-DDQNRLIDPTVRDDLVARLNGAKAEVQSVEVKHCKAVPPLGYSLPRLQI 293 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLL 359 +A+KRFGLS + L ICQ LYE ++TYPRSDC Y PE V+ A DL+ Sbjct: 294 DASKRFGLSPEATLKICQGLYEAQ-MLTYPRSDCVYAPEALKLSAEDVLLACGKV-TDLV 351 Query: 360 P--QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 + + W+ KV H+AI+PTA + L+ +E K+Y L+ +YL F D Sbjct: 352 GRFKGGLSLSRTAPVWNTAKVAEHYAILPTACPAPKALSSDEKKIYELVVTRYLAFFMSD 411 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS----------KERDEENDGTPLPVV 467 + + +I I F +K + + GW+ L K +EE + LP + Sbjct: 412 YEYEQTLIVTTIDGETFHSKGKRELQQGWKVLTAKVEDEDDSEEKKSEEEEEEDQALPEL 471 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +GD + ++++T+ P+ FT+A+LL+AM GI +FV ++KKIL+ TDG+GT AT Sbjct: 472 KQGDSGTA-SVQSLDKETKAPKRFTEASLLAAMNGIHKFVSSPEIKKILKETDGIGTAAT 530 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCR 587 +A II L G L K+ + I S+ + +AL +LPE T PDMTA WE Q+ + Sbjct: 531 QAKIIADLETSGLLIKEKKSITSSPSARALIAALPERITLPDMTALWEMKFRQLETGKAT 590 Query: 588 YQDFMQPLVGTLYQLIDQAK 607 ++ + + G + +ID+ K Sbjct: 591 FESVLDEITGEIVGMIDEVK 610 >UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F6V0_ACIC5 Length = 878 Score = 512 bits (1319), Expect = e-143, Method: Composition-based stats. Identities = 140/677 (20%), Positives = 246/677 (36%), Gaps = 86/677 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K V IGH+ + + Sbjct: 5 LVIVESPAKAKTINKYLGK-------------DFQVEASIGHIKDLPKNKLGVDVEKG-- 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + +L P K ++ +++ + I A DPDREG+ + + D L+ Sbjct: 50 -------TFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAIAAHLEDELKAV 102 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 +K + ++R N++ P+AV A+D RS L + R D + G ++ Sbjct: 103 VKKPEAIRRITFNEITPKAVTAALDHARSVDR--NLVDAQQTRRVLDRIVGYQISPLLWD 160 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-PADERFTAIWQ 241 R LS GRVQT L L+V R+++I+ F +++ + A + T + FTA + Sbjct: 161 KVRRG-----LSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEFTAHFI 215 Query: 242 PSEAC--EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + + L + L + VV ++ V K +AP PF+ S LQ Sbjct: 216 GIDGERARVETVDAPALPDQKLTDEVVAQLHKADWSVREVERKERKRNAPAPFTTSKLQQ 275 Query: 300 EAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 +A+++ G + + + + Q+LYE LITY R+D + E + Sbjct: 276 DASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEAVRGYIQ--K 333 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 D LP DAH AI P + + L++ + K+Y LI Sbjct: 334 KVGKDYLPA-----APNAFKSKKDAQDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRLIW 388 Query: 408 RQYLMQFCPDAVFRKCVIELDI---AKGKFVAKARFLAEAGWRTLLGS----KERDEEND 460 R+++ A+F + +E+ + F + G+ + K+ D+E Sbjct: 389 RRFVASQMMPAIFDQTTVEIAARADRRYDFRVTGSVMKFDGFLRVYEEVKEKKDADDEAL 448 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP + GD L + + T+PP + +A+L+ + Sbjct: 449 ANKLPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELEE-----------------R 491 Query: 521 GLGTEATRAGIIELLFKRGFLTKKG---RYIHSTDAGKALFHSLPE---MATRPDMTAHW 574 G+G +T A II + R ++ K G T+ G + L + TA Sbjct: 492 GIGRPSTYATIINTIQDREYVQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARL 551 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP-----VRQFRGIVAPGSGGSADKK 629 E L I + + R+ D + + A + + G K Sbjct: 552 EEELDDIEDGKERWTDLLNGFYDHFEDELKDAATNMEDIKRMEKPTDQKCDICGSPLVLK 611 Query: 630 KAAPRKRSAKKSPPADE 646 A + + Sbjct: 612 WGKFGSFYACSAYDKKK 628 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 512 bits (1319), Expect = e-143, Method: Composition-based stats. Identities = 222/685 (32%), Positives = 326/685 (47%), Gaps = 94/685 (13%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I EKPS+A IA L KP R+ G++E G +VTW GHLLE + R Sbjct: 1 MKLVITEKPSVALDIARALGKPTRR-QGYLEVGE-YLVTWTYGHLLEIGE-----IAPKR 53 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 WNL DLPI PEK++ Q V+++ L A +++ GD REG+L+V E+L++ Sbjct: 54 WNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDAGREGELIVRELLEFTG 113 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 R +V R ++ L V R + RLR +SEF L SALAR DW+ GIN+TR Sbjct: 114 ----YRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNGDWIVGINLTRL 169 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T+ AG V SVGRVQTP L ++V+RD EIE F + ++ V A Sbjct: 170 VTL---KAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFEGEMKG----- 221 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQ 298 ++ E L R AE VVN + + V + +R E PL SL++LQ Sbjct: 222 -------VMLRNGEEARLAREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTSLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA +GLSA+ LD+ Q LYE KLI+YPR+D RYL E + V+ + +L Sbjct: 275 REANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGR--GEL 332 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 +P+ R +D K+ HHAIIP R NL KVY+L+ R+++ F D Sbjct: 333 VPRVDRVG---KRVFDSSKLTDHHAIIPLDRPPE-NLPAIHRKVYDLVYRKFVGAFMDDY 388 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 V+ + + + F+ + + + GW L E++ +P E+ E Sbjct: 389 VYELQRVFIRLDGELFLVEGKRNLQLGWMELYPH-----EDNPLKIPS----GEVRKEWV 439 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 + ERQT+PP FT+A+LL M + LGT ATRAGIIE L +R Sbjct: 440 KAEERQTKPPARFTEASLLREMERLG-----------------LGTPATRAGIIETLLER 482 Query: 539 GFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQI---SEKQCRYQDFMQP 594 G++ ++G+ ++STD G+ L L PDMTA WE L +I + YQ+FM+ Sbjct: 483 GYVERRGKSLYSTDKGRELVDKLGDSKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEG 542 Query: 595 LVGTLYQLIDQAKRTPVRQFR-----------------GIVAPGSGGSADKK---KAAPR 634 + + +++ + + R G+ G+G K+ + P+ Sbjct: 543 IRRFTREEVERLMKREFKVERRATPEMLRLARAVSRDLGVKLEGTGMEEVKRFLDENLPK 602 Query: 635 KRSAKKSP----------PADEVGS 649 R K + G+ Sbjct: 603 MRITCKCGGEVVGFSRGWKCRKCGT 627 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 511 bits (1317), Expect = e-143, Method: Composition-based stats. Identities = 131/665 (19%), Positives = 250/665 (37%), Gaps = 76/665 (11%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P + G + GH+ + Sbjct: 3 KLVIVE-------------SPSKSKSLKKYLGADYDILASYGHVRDLEPRTGAVDTEN-- 47 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + Q K ++ I + +A E++ A DPDREG+ + + + L+ Sbjct: 48 ---------FSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAISWHISEILKE 98 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + ++R ++ A++ A+ R + L + AR D+L G N++ Sbjct: 99 K-KVKTPMKRVAFYEITESAIQDAVRNPREIAS--DLVDAQQARRALDYLVGFNLSPLLW 155 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 LS GRVQ+P L ++V R+EEIE FVA++++ + + FTA Sbjct: 156 KKISPG-----LSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLD-SHKGSQAFTAKLT 209 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 + + ++ + H ++ + + + A V KR + + PF+ S LQ Sbjct: 210 HFKGEKL---DQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAG 266 Query: 302 AKRFGLSAQNVLDICQKLYETH-------KLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G++ V+ Q+LYE LITY R+D L +E + A Sbjct: 267 VRQLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGAN--F 324 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP V + + +AH A+ PT+ + LT+++A++Y L+ ++ Sbjct: 325 DKDYLPPHAVQYKAKTK----NAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKR 380 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 + A F ++ + +G F A + LA AG+ + ++ +++ + LP + + Sbjct: 381 TVACQMTAAQFDTVAADITVGEGTFRATGQTLAFAGFLAVY--QDDEDDEGESKLPALVE 438 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ L ++ + TQPP +T+A+L+ A+ G+G +T A Sbjct: 439 GETLPVDRLYGEQHFTQPPPRYTEASLVKALEE-----------------YGIGRPSTYA 481 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 II L R ++ + + TD G+ + L D TA E L +S + Sbjct: 482 SIISTLQDREYVVLEKKRFQPTDVGRLVNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKR 541 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + + + + P + + P + Sbjct: 542 VWSRLLGEFWSGFEGDLKAKQDVERGCPILEACPKCAKPLFMQASKRGLFIGCSGYPECD 601 Query: 647 VGSGA 651 Sbjct: 602 YTRPL 606 >UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YKX8_THEYD Length = 777 Score = 511 bits (1316), Expect = e-143, Method: Composition-based stats. Identities = 129/676 (19%), Positives = 244/676 (36%), Gaps = 85/676 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I ++ K V IGH+ + + + Sbjct: 8 LIIVESPAKAKTINKIVGK-------------DFQVKASIGHIKDLPEDRLGVDIEKGFQ 54 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P K + +K A +I A DPDREG+ + + + +++ Sbjct: 55 PD----------YIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAYHIAEEIKVP 104 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 +V R + +++ P AV+ AI + S AR D L G N++ Sbjct: 105 EN---KVYRAIFHEITPNAVKAAIANPSKID--INKVYSQQARRILDRLVGYNLSPFLWK 159 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD-ERFTAIWQ 241 + LS GRVQ+ L +VV R++EI F ++++ + + + + A Sbjct: 160 KVKKG-----LSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLY 214 Query: 242 PSEAC----EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + + + A+ ++ + I+T K++ ++ P PF + L Sbjct: 215 KYKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATL 274 Query: 298 QIEAAKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNA 350 Q +A+ G S + + + Q+LYE LITY R+D + EE ++ Sbjct: 275 QAQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIE- 333 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 + + + + + DAH I PT + LT+ + +Y L Sbjct: 334 -KNFGKEFVGNHKIHETKKQKT---PIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKL 389 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERDEENDGTP 463 I ++L A + ++ +F + G+ + + +E + T Sbjct: 390 IWDRFLASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIY---KDEESEEDTV 446 Query: 464 LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLG 523 LP + + L + E + T+PP +T+ATL+ A+ G+G Sbjct: 447 LPQLNEKTSLKISELEAQKHTTEPPPRYTEATLVKALEE-----------------KGIG 489 Query: 524 TEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQ 580 +T A I+ + +RG++ K + + T G + L E TA E L + Sbjct: 490 RPSTYATILSTIQERGYVKKVKQKLQPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDK 549 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGSADKKKAAPRK 635 IS + ++ ++ +DQA + P G + + Sbjct: 550 ISLNEAKWNKVIEEFYKEFENDLDQASKISKVIKPKEIKTSFKCEKCGKDMVIRWSKGVP 609 Query: 636 RSAKKSPPADEVGSGA 651 A P + Sbjct: 610 FLACSGYPECKNTRSL 625 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 194/661 (29%), Positives = 308/661 (46%), Gaps = 65/661 (9%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A A + +K DG+IE G +TW +GHLLE A Sbjct: 1 MKLIIAEKPSVAIDTAKAISPKFQKKDGYIEAGE-YTITWAVGHLLEIDDTIAP----KE 55 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 W L LPI+PEK++ + KQ N++K + +A EI D REG+L+ +L Y Sbjct: 56 WKLETLPILPEKFEYKVSKGKNKQFNIVKSLVKKADEIFVNTDAGREGELIARLILLYSG 115 Query: 121 LAPEKRQQVQRCLIND-LNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + R ++ L + R + + + L S LAR ++DWL GIN+TRA Sbjct: 116 W--NGWDKTYRFWTSEALTKNVILRELKARKPAKNWDSLFYSGLARQQSDWLVGINLTRA 173 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 T++ G V S+GRVQTPVL L+V RD EI+NF K +++++A ++F A Sbjct: 174 LTVIV---GDGSVWSIGRVQTPVLKLIVERDLEIKNFKPKPYWQLEAVFE-KDSQKFKAK 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ-PAIVTSYNDKRESESAPLPFSLSALQ 298 +++ + + + + A+V K+ + AP FS++ LQ Sbjct: 230 L--------LNEKDTIFEDKNKIWEIFKALKDKDKAVVKEIEKKQHKKYAPPLFSITTLQ 281 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 + A KRFG +AQ L + Q LYE K I+YPR++ ++L +E+ + + V N + + Sbjct: 282 MTANKRFGFTAQKTLMLAQDLYEA-KYISYPRTEAQHL-DENPSTKDLVKNILKKLGEEQ 339 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLMQ 413 L + V R +D K+ H+AIIP ++ L ++ K+Y LI ++L Sbjct: 340 LIENVDKVG--KRVFDSSKLTDHYAIIPMNLLTEEKAKKEGLNQDHLKIYELIKNRFLAV 397 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 F P + LDI +F A + GW+ + +E +++ PLP + KGD + Sbjct: 398 FMPPYEYETTKAILDIDGYQFTASGKVELSLGWKAI--DREDEDDKIEAPLPQLEKGDMV 455 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 V+E +T+PP H+T++TLL+ M + LGT ATRAGII+ Sbjct: 456 HKISQRVIEDKTKPPAHYTESTLLNKMKQL-----------------ELGTGATRAGIIQ 498 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMATRPDMTAHWESVLTQISE---KQCRYQ 589 L R ++ KG+ + +T+ G AL + + P MT+ WE L QI + Y+ Sbjct: 499 TLKDRFYIKNKGKSLIATEKGFALIEKIKDKEFASPKMTSKWEQQLEQIYTQKLGKKGYE 558 Query: 590 DFMQPLVGTLYQLIDQAK--RTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 DF+ + + ++ K + Q GG K Sbjct: 559 DFLNQIKEFTKKEVEAVKGISIQMEQKPVGRC-RCGGDV---------FEYGKYYQCGSC 608 Query: 648 G 648 Sbjct: 609 N 609 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 150/672 (22%), Positives = 249/672 (37%), Gaps = 89/672 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR+I +L G V +GH+++ + + Sbjct: 18 LVVVESPAKARSIQKMLG-------------PGYEVRASLGHVVDLPERSLGVDVERDFA 64 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + +KR E ++ A DPDREG+ + V L Sbjct: 65 P----------TYEVKKDKKPVVEELKRAA-EGKRLLIATDPDREGEAIGWHVARLLGRD 113 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P++ R +++ P+ V +A++ R + L + AR D L G N++ ++ Sbjct: 114 PKEPL---RVEFHEITPRVVRQAVEAPRPIDQ--NLVDAQQARRVLDRLLGYNLSPLLSL 168 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE-RFTAIWQ 241 R LS GRVQ+ L LVV R+E IE F ++++ ++ E A Sbjct: 169 EFRK----RALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLH 224 Query: 242 PSEACEPY-----QDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 E + ++ L A + + V + ++ P PF+ S Sbjct: 225 EVEGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTST 284 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMN 349 LQ A+ R G +A + I Q+LYE T LITY R+D + E A V+ Sbjct: 285 LQQAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIG 344 Query: 350 AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYN 404 P+ LP+ R + DAH AI PT L+E E ++Y Sbjct: 345 --KAFGPEYLPEAPRAYKNRR----EGVQDAHEAIRPTDPKRTPESVRPYLSEEEYRLYE 398 Query: 405 LIARQYLMQFCPDAVFRKCVIELDI--AKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 LI R++L DA++ + + L + F A L G+ G +EE Sbjct: 399 LIWRRFLASQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPV 458 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 P V +G E+ R T+PP +TDA+L+ M + + Sbjct: 459 P--AVPEGVPARLEEVLEERRFTEPPPRYTDASLVKTMEELG-----------------I 499 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A +E L KRG++ +KGR + T G+ + L E + TA E L Sbjct: 500 GRPSTYAPTLETLEKRGYVARKGRTLFPTPLGRQVTAYLRERFPQVVAYEFTARMEERLD 559 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAK 639 ++ E + + + + Q + P G + K + + Sbjct: 560 EVEEGRVPWPKVVWEFYEPFLGELAQVPKK--------TCPRCGRPLELKVSRYGQFLGC 611 Query: 640 KSPPADEVGSGA 651 P Sbjct: 612 TGYPECTYTEPL 623 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 510 bits (1313), Expect = e-143, Method: Composition-based stats. Identities = 144/663 (21%), Positives = 256/663 (38%), Gaps = 81/663 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I L K V GH+ + + + Sbjct: 4 HLLIVESPAKAKTINKYLGK-------------DFTVLASYGHVRDLVPKEGAVDPENGF 50 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 + + K + I + A I A DPDREG+ + + + L+ Sbjct: 51 AM----------RYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKE 100 Query: 122 APEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + +QR + ++ P+A++ AI + R + L + AR D+L G N++ Sbjct: 101 RGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIAS--DLVDAQQARRALDYLVGFNLSPVL 158 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + LS GRVQ+P L ++V R+EEIE F+ ++++ + A PA F+A Sbjct: 159 WRKVQRG-----LSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECTHPAQH-FSAKL 212 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + Q A+ + + + +T +K PF S LQ E Sbjct: 213 IKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAPPFITSTLQQE 272 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A+++ G + + + I QKLYE + LITY R+D L + + ++ Sbjct: 273 ASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDII---- 328 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-----AINLTENEAKVYNLIA 407 A D + D +AH A+ PT+ A L+ E ++Y L+ Sbjct: 329 --ARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVW 386 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGK-FVAKARFLAEAGWRTLLGSKER----DEENDGT 462 ++ + A+ ++L F A + G+ + + +++++G Sbjct: 387 KRTVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGR 446 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LPV+ G+ + E+ + TQPP +T+A L+ A+ G+ Sbjct: 447 KLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEE-----------------YGI 489 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A II+ L R ++ +GR TD G+A+ L D TAH E L Sbjct: 490 GRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELD 549 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG-----IVAPGSGGSADKKKAAPR 634 IS + + M+ +L++ K + + G + P SG + Sbjct: 550 AISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSARIGRFG 609 Query: 635 KRS 637 Sbjct: 610 PMV 612 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 509 bits (1312), Expect = e-142, Method: Composition-based stats. Identities = 131/671 (19%), Positives = 259/671 (38%), Gaps = 81/671 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I+ L V +GH+ + + Sbjct: 8 LVIVESPAKAKTISKFLDAS-------------FFVKSSMGHVRDLPAKKLSVDIENDFT 54 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + PS K + + +AS + A D DREG+ + + L + Sbjct: 55 PE----------YKVIPSREKLIKELISDSKKASTVYLASDLDREGEAIAWHLYKVLDIP 104 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 PE +++R N++ A++ A + + + + AR D + G ++ Sbjct: 105 PE---KIRRVTFNEITKDAIQEAFKQYGPIN--MEKVNAQQARRILDRIVGYKISPLLWK 159 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 LS GRVQ+ + L+V R++EI F +++++ A + T + ++ + +P Sbjct: 160 KIAKR-----LSAGRVQSVAVRLIVEREKEINEFKPHEYWKITAELKTISGDKKSDDIKP 214 Query: 243 SEAC-EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 +A + +D+ + + A+ + ++ I+T+ + + +AP PF+ S LQ +A Sbjct: 215 FKALLQKLEDKNIEIKNEQQAKEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQQQA 274 Query: 302 AKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 + R SA+ + I Q+LYE LITY R+D ++ + + S Sbjct: 275 STRLQFSAKKTMLIAQQLYEGIDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIE--SN 332 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIAR 408 + D LP+ + AH A+ PT S LT+++ K+Y LI + Sbjct: 333 YGKDYLPEKPNIYASNKK----GTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWK 388 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 +++ A++ +E+ + F + R L G + G + EE LP + Sbjct: 389 RFVASQMKPALYAITDVEITSNRYIFKTRGRELLFDGHTLISGHEVDREE---QILPPLE 445 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 K L + + TQPP +++A+L+ + + +G +T Sbjct: 446 KDHVLELIQLLPTQHFTQPPPRYSEASLVKTLEKMG-----------------IGRPSTY 488 Query: 529 AGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQ 585 A II + RG++ ++ R ++T+ G + L E + T+H E L +I EK+ Sbjct: 489 ATIISTIQDRGYVKQEKRAFYATELGILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKK 548 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPVR-----QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 + ++ +++A + + + K Sbjct: 549 IDWLTVLKEFYEPFKIDLEKAIGEMKSVKGTPEESDRICNLCSKPMVIRWGRHGKFFGCS 608 Query: 641 SPPADEVGSGA 651 + P + Sbjct: 609 AFPECKNTMPL 619 Score = 43.1 bits (100), Expect = 0.038, Method: Composition-based stats. Identities = 2/39 (5%), Positives = 6/39 (15%) Query: 613 QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + G + + + P Sbjct: 675 EPTNEKCEKCGSPMVIRFSKKGRFMGCSGYPKCRNIKSL 713 >UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi RepID=A5CF60_ORITB Length = 788 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 134/691 (19%), Positives = 258/691 (37%), Gaps = 96/691 (13%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L I E P+ A+ I L + V GH+ + Sbjct: 1 MKLLIVESPAKAKTINKYLG-------------SDFQVVASYGHVRDLLAKAGSV----- 42 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 LP + + P T+ + I ++ I A DPDREG+ + +++ L+ Sbjct: 43 -----LPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIVEVLK 97 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 +R + N++ +A+ A+ + R + + L + AR D+L G +++ Sbjct: 98 EKKIF-ANFKRIIFNEITKKAIGDALQQPRDIN--LNLVNAQQARRSLDYLVGFSLSPLL 154 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 G S GRVQ+ L L+ R+EEI F++++++ + +++ DE TA Sbjct: 155 WRKL-----PGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKL 209 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + E+ + ++ A+ +V I Q V K+ +S P PF S+LQ E Sbjct: 210 IEFDGNKL---EKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQE 266 Query: 301 AAKRFGLSAQNVLDICQKLYETHK-------LITYPRSDCRYLPEEHFAGRHAVMNAISV 353 AA + G +A+ + I QKLYE LITY R+D L ++ ++ S Sbjct: 267 AAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFIS--SS 324 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL-----TENEAKVYNLIAR 408 + LP+ + + + +AH AI P + L ++ K+Y LI + Sbjct: 325 FGNNYLPRQIRAFKSKVK----NAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQ 380 Query: 409 QYLMQFCPDAVFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 + + + + I A +A G+ + DEE + LP Sbjct: 381 RTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGFYKVYKEIN-DEEENKKLLPN 439 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +++ + + + + T+PP +++ATL+ + + +G + Sbjct: 440 LSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLG-----------------IGRPS 482 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISE 583 T A II +L +R ++ + + G+ + L D TA E L I++ Sbjct: 483 TYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAK 542 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------------------APGSG 623 +Q+ ++ + + ++ + + Sbjct: 543 GMIGWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPVQNGETDHKLCTLCK 602 Query: 624 -GSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 G K + A + P+ A Sbjct: 603 VGKLSLKLSKYGAFLACNNYPSCNFTRNIAA 633 >UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Group II RepID=A3EPL6_9BACT Length = 850 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 144/677 (21%), Positives = 244/677 (36%), Gaps = 90/677 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR ++ VL +G +V +GH+ + + Sbjct: 52 LIIVESPTKARTLSKVLG-------------SGYLVKASVGHVKDLPPSRLGIDVDHDFA 98 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L + P K L+ I+ A E+ A DPDREG+ + + L+ Sbjct: 99 LE----------FEVHPDKKKVLSEIRSEARSAREVYLASDPDREGEAIAYHIASELEAL 148 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P +R L ++L + A+ V + AR D + G ++ Sbjct: 149 P---VPPKRVLFHELTEGGIRSALSEPGEID--VRKVEAQKARRALDRIVGYTISPLLWD 203 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ + LV R++EI FV ++++ + A Sbjct: 204 RVRRG-----LSAGRVQSVAVRLVCDREDEIARFVREEYWTIDARFRPGDPRVPPTFLSR 258 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + E+ L A V RI + V + + P + S LQ EAA Sbjct: 259 LD---RVSGEKPVLPDARTAGQAVERIRRERFTVGEITRADKKRNPSPPLTTSRLQQEAA 315 Query: 303 KRFGLSAQNVLDICQKLYET--------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 R SA+ + + QKLYE LITY R+D + E + + H Sbjct: 316 NRLRFSAKKTMTVAQKLYEGVDLPGQGPVGLITYMRTDSVRVSPEAAEAARSWI---RQH 372 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 PD LP R DAH AI P T S ++ + ++Y+LI + Sbjct: 373 HPDGLPARAPAYKNRKGI-----QDAHEAIRPSDVRRTPESLQGSIDPDLFRLYDLIWKS 427 Query: 410 YLMQFCPDAVFRKCVIELDIA-KGKFVAKARFLAEAGWRTLLGSKERD------EENDGT 462 ++ A++ + + ++ F A R L G+ L G E + Sbjct: 428 FVESQMSPALYLQTTVLVEGDQGDVFRASGRVLKSPGFLALRGLSVAPEDGAGEGEGEDR 487 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + G+ + E+ + T+PP +++A+L+ + G+ Sbjct: 488 LLPPLETGEIVSLEEVTPDQHFTEPPPRYSEASLIRELEE-----------------KGI 530 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLT 579 G +T A I+ + R ++ KK + TD GKA+ L E TA E L Sbjct: 531 GRPSTYATILSTIQDREYVEKKENRFYPTDLGKAVNSLLVESFPDLMSVRFTARMEEELD 590 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKR------TPVRQFRGIVAPGSGGSADKKKAAP 633 Q+ E + Y+D + + +++AK+ + + P ++K Sbjct: 591 QVEEGERGYRDVVGDFYTPFHHEVEKAKKGGMTNLKKLEVPTDVSCPVCQAPMNRKWGKN 650 Query: 634 RKRSAKKSPPADEVGSG 650 + P + Sbjct: 651 GSYLSCSRYPECKTTRN 667 Score = 45.4 bits (106), Expect = 0.007, Method: Composition-based stats. Identities = 6/41 (14%), Positives = 9/41 (21%) Query: 611 VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 V V P +K+ A P + Sbjct: 731 VSPAEAPVCPECSSPMVQKRGRFGSFWACSRYPECKGTRPL 771 >UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=D0KVS8_HALNC Length = 834 Score = 508 bits (1309), Expect = e-142, Method: Composition-based stats. Identities = 145/663 (21%), Positives = 251/663 (37%), Gaps = 81/663 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L G V GH+ + D + Sbjct: 5 LVIVESPAKAKTIKKYLG-------------PGYEVLASYGHVRDLIPKDGAVDTAHDFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + ++ IK+ L + ++ A DPDREG+ + + + L A Sbjct: 52 MN----------YTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEA 101 Query: 123 PE-KRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 K + QR + ++ +AV+ A+ R S + L + AR D+L G N++ Sbjct: 102 GLLKNKTAQRVVFYEITKKAVQEAVAHPRDLS--IDLINAQQARRALDYLVGFNLSPLLW 159 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 LS GRVQ+P L L+V R+ EIE F ++++ + A + Sbjct: 160 KKI-----NPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNA 214 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA---IVTSYNDKRESESAPLPFSLSALQ 298 + + E+ L + A+ +RI A V S + + PF+ S LQ Sbjct: 215 RLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 E ++ GLSA V+ + Q+LYE T LITY R+D L E+ A + Sbjct: 275 QEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIG-- 332 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 + LP R + +AH AI PT+ + + L +++ ++Y +I Sbjct: 333 DKYGAAYLPAS----PNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMI 388 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERD---EENDGT 462 ++ + AV+ + ++L + F A L G+ L E D + ++ Sbjct: 389 FKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDR 448 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LP + GD++ + T+PP FT+A+L+ + G+ Sbjct: 449 RLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEE-----------------YGI 491 Query: 523 GTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLT 579 G +T A II L R ++ R TD G+ + L + + TA E L Sbjct: 492 GRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLD 551 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG-----IVAPGSGGSADKKKAAPR 634 +S + + M+ + ++ RQ + P SG + Sbjct: 552 AVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELGIDPKSGKPVSVRLGRFG 611 Query: 635 KRS 637 + Sbjct: 612 PFA 614 >UniRef50_C9Q4L2 DNA topoisomerase n=1 Tax=Vibrio sp. RC341 RepID=C9Q4L2_9VIBR Length = 736 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 238/675 (35%), Positives = 357/675 (52%), Gaps = 38/675 (5%) Query: 1 MRLFIAEKPSLARAIADVLPK--PHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MR+FIAEKPSLA AI L K +G+ + G VVTWC+GHLL P+ Y+ + Sbjct: 1 MRVFIAEKPSLAAAIFKGLGGDVNTEKKNGYYQHGQD-VVTWCLGHLLALCDPEDYNIEH 59 Query: 59 ARWNLADLPIV-PEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 +W L+ LP+ +L+PR KQL V+ ++ +A+ IVHAGDPD EG LL+DEVL Sbjct: 60 KKWALSYLPLETMYPPRLKPRKGAEKQLKVVLEWIGKATSIVHAGDPDPEGCLLIDEVLQ 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + VQR LI DLN + V+ A+ L+ N F+PL ALAR+ AD +G N+T Sbjct: 120 YA----NNTKPVQRVLIADLNDKPVKAALANLQPNENFLPLTQKALARSIADQTFGYNLT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RAYT+ R G+ VL++GRV T ++G++ R +N ++E+ H + Sbjct: 176 RAYTLKAREKGFDDVLNIGRVITAMIGMINERTLANQNHQKSFYYELFGHFSVAGN-TIK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A P E E DE+GR++ + A++ S K ES +APLPF+LS L Sbjct: 235 AKLIPDEHFEL--DEQGRMISSLEVAATKEADTNASAVIQSVEQKEESRAAPLPFNLSKL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 QIEA+KR+G + VLD Q LYE HKL+TYPRSD ++L + H + AI P Sbjct: 293 QIEASKRWGYKPKEVLDALQALYEKHKLLTYPRSDNQFLSDAHLENAPQIFAAIQGTMPH 352 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVDAHHAIIPTARS-SAINLTENEAKVYNLIARQYLMQFC 415 L P ++ ++ K++AHHAI+PT +S + I L E + +Y LIA++++ F Sbjct: 353 LSDAVTQATPTSTHKAFNAAKIEAHHAIVPTEKSGAGIELNERKKNLYELIAKRFVALFY 412 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG-TPLPVVAKGDELL 474 PDA K + ++ + A L GW L + DE N L + +G E Sbjct: 413 PDAKRSKVMADIACTGRIYRATQTTLTTQGWEVLFKGEHNDEPNQNLIDLSTLTEGAEAR 472 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG--------LGTEA 526 C ++ ER+T+PP++F DA+LL AMT A+F++D L+K L A D +GTEA Sbjct: 473 CSHLDMEERETKPPKYFDDASLLKAMTQAAKFIKDPVLRKTLEAKDKDTAGENGSIGTEA 532 Query: 527 TRAGIIELL----------FKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 TR+G IE + ++G+ K +T+AG+ LP+ RPD++A WE Sbjct: 533 TRSGHIEKVGKLTHLVTLTKEKGY---KNPVYKTTEAGQEFCALLPDEIVRPDISAIWEG 589 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT--PVRQFRGIVAPGS-GGSADKKKAAP 633 L +I++++ + F+ + + +D K P + +G+V P G+ K+K Sbjct: 590 SLNKIAKREESIEAFLHSVNHYIATQVDHVKTQGVPFSKRQGMVCPTCQQGTLTKRKGQN 649 Query: 634 RKRSAKKSPPADEVG 648 + P + Sbjct: 650 GPFWSCNRYPDCKTT 664 >UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HWV0_9BACT Length = 865 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 132/691 (19%), Positives = 246/691 (35%), Gaps = 105/691 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ AR + +L V +GHL + + Sbjct: 50 LIVVESPTKARTLTRILG-------------PDYRVKASVGHLKDLPASRIGVDVDRDYE 96 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L + K L+ I++ A EI A DPDREG+ + + L Sbjct: 97 LE----------FEVSEGKKKVLDEIRQAARGAREIYLASDPDREGEAIAYHIASEL--- 143 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ ++R L+++L P+ + +A++ + + AR D + G +++ Sbjct: 144 SSLKKPIRRVLVHELTPRGIAQALEHPGEID--LHKVDAQKARRALDRIVGYSLSPLLWE 201 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI----VTPADERFTA 238 R LS GRVQ+ + LV R+ EI FV +++ + + F A Sbjct: 202 RVRRG-----LSAGRVQSVAVRLVCDRENEINAFVPVEYWTILQTFHPTESGRETDAFEA 256 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 E+ + + A+ V+ R+SG+ + S + + P + S LQ Sbjct: 257 KLDRIAG------EKAEIGSQQEAQAVLERLSGENFRIGSVSADEKKRQPSPPLTTSRLQ 310 Query: 299 IEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNA 350 E A+RF A+ + + QKLYE LITY R+D L E + Sbjct: 311 QEGARRFRFPAKKTMQVAQKLYEGVEIPGQGLTGLITYMRTDSVRLAPEAQEMARDYIRR 370 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 + + DAH AI PT + L + +VY L Sbjct: 371 NYPQG--------LPSKSPSYRNKKGIQDAHEAIRPTDVNRTPESLASVLDRDLLRVYQL 422 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDE------- 457 I + ++ A + + + ++ + F A R + + G+ + G++ + Sbjct: 423 IWQSFVESQMLPARYLQTTVIVEGDQADSFRATGRRMLDPGFLAVRGARGKGAARSAKNE 482 Query: 458 ------ENDGTPLPVVAKGD-ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDK 510 + + LP++ +G+ + + + TQPP + +A+L+ + Sbjct: 483 EEEDGTDEEEAELPLLHEGESVVALGPPDASQHFTQPPPRYNEASLIRELEE-------- 534 Query: 511 DLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATR 567 G+G +T A I+ + R ++ K+ + T+ G+ + L + Sbjct: 535 ---------KGIGRPSTYATIMTTILDREYVEKRENRFYPTELGQTVNRLLVDSFPDLLN 585 Query: 568 PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR------TPVRQFRGIVAPG 621 TA E L + E Y++ + + +AK + I P Sbjct: 586 VAFTARMEEELDAVEEGDKVYREAVDDFYRPFSAELGRAKGGGMTNLKAKSEPTDIPCPV 645 Query: 622 SGGSADKKKAAPRKRSAKKSPPADEVGSGAI 652 G KK A + PA + + Sbjct: 646 CGTLMVKKWGRHGAYLACGNYPACKTTRNIV 676 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 506 bits (1304), Expect = e-142, Method: Composition-based stats. Identities = 160/683 (23%), Positives = 280/683 (40%), Gaps = 73/683 (10%) Query: 1 MRLFIAEKPSLARAIADVLP-----KPHRKGDGFIE---CGNGQVVTWCIGHLLEQAQPD 52 M L IAEKP++AR IA L K G + E G +V +GHL A Sbjct: 1 MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKR 60 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 + + D+ VP + + + + + E + A D D EG+++ Sbjct: 61 DVFG----YPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIG 116 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 L Y + +R + L + + A L F + + +AR DW + Sbjct: 117 YTALKYACGVDPR--VAKRMKFSALTKRDLLNAWRNLEPTINF-GMANAGIARHILDWYW 173 Query: 173 GINMTRAYTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N++RA T + A G VLS GRVQ P L +V R+ EI++FV + ++ +K Sbjct: 174 GVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFE-K 232 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 ++FTA + E+ ++ + +V + V++ KR+ + P P Sbjct: 233 NGQKFTANY-----------EKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHP 281 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F L LQ EA FG S + LDI Q LYE +YPR++ + LP R + N Sbjct: 282 FDLGTLQREAYSAFGFSPKKTLDIAQSLYE-KGFSSYPRTESQKLPRN-INFRMIIQNLA 339 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQY 410 + ++ K+ AH AI PT +LT++E K+Y++I R++ Sbjct: 340 KMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRF 399 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L F A+ + + KF + GW ++ G + EE LP G Sbjct: 400 LAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEE---VTLPEFFIG 456 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + + + + +++T+PP ++ A ++ M + LGT+ATRA Sbjct: 457 ERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLG-----------------LGTKATRAQ 499 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCR 587 I+E L++RG++ K + I T G + +L + ++T +E + I E + Sbjct: 500 ILETLYQRGYIEGK-KSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLT 558 Query: 588 YQDFMQPLVGTLYQLIDQAKRT----------------PVRQFRGIVAPGSGGSADKK-- 629 ++ ++ L +++++ K+ V+ P GG K Sbjct: 559 KEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYN 618 Query: 630 KAAPRKRSAKKSPPADEVGSGAI 652 K ++ + P +V + Sbjct: 619 KKTGKRFVGCSNWPKCDVTYPIL 641 >UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYR4_UNCTG Length = 740 Score = 506 bits (1304), Expect = e-141, Method: Composition-based stats. Identities = 126/672 (18%), Positives = 263/672 (39%), Gaps = 84/672 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + I+ +L K V GH+ + + + Sbjct: 5 LVIVESPTKEKTISKILGK-------------DFTVKSSYGHIRDLPKNKLGIDIEDNFK 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + K ++ +K+ + +I A D DREG+ + + + L+L Sbjct: 52 P----------TYKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIAWHLKEALKL- 100 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++ R +++ +A+ +A+ R+ + L S AR D L G ++ Sbjct: 101 --PESKISRITFHEITTEAILKAVKHPRNLD--MKLVNSQQARRILDRLVGYKLSPLLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT--PADERFTAIW 240 + LS GRVQ+ + L+ +R+EE ++F+ +++ ++A + F ++ Sbjct: 157 KVKPG-----LSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELSKLEENTTPFKSLL 211 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + + ++ + ++ ++ + + G IV S K+ S P++ S +Q + Sbjct: 212 ---FSKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQD 268 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A+++ G SA + QKLYE LITY R+D + + + + Sbjct: 269 ASRKLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIE--Y 326 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + LP + +AH AI P + + + L+E+E K+YNLI Sbjct: 327 SYGSNFLP----KIPRIYKTKTKGAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIW 382 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 +++L DAV+ E+ F + L G+ + D+E + LP + Sbjct: 383 KRFLASQMADAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYN--ADDDEKETKKLPSL 440 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G++L + ++ T+PP + A+L+ A+ G+G +T Sbjct: 441 KSGEQLNLLRLLPLQHFTEPPPLYDVASLIKALEE-----------------HGIGRPST 483 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEK 584 A I+ + R ++ G+ T+ G + + L + + TA E L +I+E Sbjct: 484 YAPTIKTILDRLYVHLDGKKFVPTNRGIVVNNVLKDHFGNIINVEFTASVEEKLDKIAED 543 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQF-----RGIVAPGSGGSADKKKAAPRKRSAK 639 + +Q+ ++ + + +A++ +Q + P G + + + + Sbjct: 544 KAVWQNVLKDFYKPFKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKVQFLGC 603 Query: 640 KSPPADEVGSGA 651 P + Sbjct: 604 SGYPECKTTLSL 615 >UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QYG0_BRAHW Length = 716 Score = 506 bits (1304), Expect = e-141, Method: Composition-based stats. Identities = 134/670 (20%), Positives = 243/670 (36%), Gaps = 84/670 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + +V +GHL++ + + Sbjct: 28 LVIVESPAKAKTINRYLG-------------SDYLVMSSMGHLIDLPRSRLAIDVDHGFE 74 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 K LN +K+ +A E++ A D DREG+ + + + ++ Sbjct: 75 PE----------YITIRGRAKILNELKKEAKKAEEVLLAADDDREGESIAWHIGNKIR-G 123 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 ++R + +++ A++ AID+ R + + AR D L G N++ Sbjct: 124 VNSAVPIKRIVFHEITKDALKEAIDQPRDID--ISKVNAQKARRVLDRLIGYNLSPLLWD 181 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ L ++ R++EIE FV +++ + E F A Q Sbjct: 182 KIKRG-----LSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKE-FLAELQK 235 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 Y+ E+ L + E ++ + + V S K + P++ S LQ A+ Sbjct: 236 ------YKGEKPDLKTKQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAAS 289 Query: 303 KRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G SA + + Q LYE LITY R+D + + + Sbjct: 290 SALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIE--KEYG 347 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-----SSAINLTENEAKVYNLIARQY 410 + LP P+ DAH AI PT S L ++ K+Y LI ++ Sbjct: 348 SNYLP-----PEPPTYSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERF 402 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + A + + +F + + G+ +L + D+E + +P ++K Sbjct: 403 VSSQMLPAKMKNTRAIIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEK-ASKMPNLSKD 461 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D + + T PP +TDA+L+ + G+G +T A Sbjct: 462 DVCEFVENNPQQHFTTPPPRYTDASLVKILEE-----------------SGIGRPSTYAP 504 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCR 587 I+ + R ++ +KG+ + T+ GK + + E + TA ES L +I + Sbjct: 505 TIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIE 564 Query: 588 YQDFMQPLVGTLYQLIDQAKRTP------VRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 + + ++ + A + V G K+ A Sbjct: 565 WNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSG 624 Query: 642 PPADEVGSGA 651 P + G Sbjct: 625 FPECKNTKGI 634 >UniRef50_B5Y9I3 DNA topoisomerase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y9I3_COPPD Length = 685 Score = 506 bits (1303), Expect = e-141, Method: Composition-based stats. Identities = 196/658 (29%), Positives = 311/658 (47%), Gaps = 54/658 (8%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L + EKPS+AR IA L KP K +G V+ +GHLL+ A P+ Y RY +W Sbjct: 3 ILIVTEKPSVARQIAAALGKP--KKEGNHLVVGEYVIAHAMGHLLQFAYPEHYGERYKKW 60 Query: 62 NLADLPIVP--EKWQLQPR-PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 L DLPI+P ++WQL P + KQL IK +A ++ A D REG+L+ + Y Sbjct: 61 RLEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQY 120 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + + + ++R + L + + I +L SE L SALARA+ADWL GIN +R Sbjct: 121 VGI----EKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASR 176 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 A+T++ + V S+GRVQTP L ++V R++EI++FV + +++VK Sbjct: 177 AFTVVSKK----EVFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEG------ 226 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + E + + AE + + G+ IVT +++ + PL L LQ Sbjct: 227 --------KSFWAESVKEYDQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQ 278 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 ++ F SAQ L I QKLYE + LITYPR+D RYLP + N + Sbjct: 279 KFTSRSFKWSAQKTLKILQKLYE-NALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKG 337 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDA 418 + V + R R +++ +V H AIIPT + L ++ K++N + ++L F P A Sbjct: 338 NWEYVKKLNNRGRIFNNARVTDHFAIIPTGKIK--ELKGDDEKMFNYVVDRFLAAFYPPA 395 Query: 419 VFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKG 478 + F A + + W T+LG KE E LP +A+ ++ + Sbjct: 396 LETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQE-----LLPKIAE---VMVLET 447 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 +RQT+P FTD L++AM + V+ ++L +IL+ G+GT ATRA IIE L + Sbjct: 448 SAEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKEK-GIGTPATRAEIIERLIEM 506 Query: 539 GFLTKKGRYIHSTDAGKALFHSLPEM----ATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 G++ + G + T G L +L E+ T P++T WE L I + + + FM Sbjct: 507 GYVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFMWS 566 Query: 595 LVGTLYQLIDQAKRTPVRQFR-------GIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 + + ++ + + P G +K + Sbjct: 567 IEEYVKDVVQTLSKEESSKTLKSKQNMPIAKCPFCDGYIL----EGQKSYYCSNWKEG 620 >UniRef50_C7HGZ2 DNA topoisomerase n=2 Tax=Clostridium thermocellum RepID=C7HGZ2_CLOTM Length = 652 Score = 506 bits (1303), Expect = e-141, Method: Composition-based stats. Identities = 199/642 (30%), Positives = 322/642 (50%), Gaps = 36/642 (5%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGD--GFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 +L+I EKPS+A + A+VL K D VVTWC GHL+ A PDAYD +Y Sbjct: 4 KLYITEKPSVAASFAEVLGMKITKQDRSKGYAESEHSVVTWCFGHLITMAYPDAYDPKYR 63 Query: 60 RWNLADLPIVPEKWQLQPRPS--VTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEV 115 W + DLPI+P+ ++ + KQ IK ++ + I D REG+ + V Sbjct: 64 EWKVEDLPIIPKVYKYIVIDDEGIKKQFETIKTLMNREDIDLIFACTDSGREGEYIFRLV 123 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + ++ +R I+ +A+ I + E+ L +A +RA+ DWL+G+N Sbjct: 124 YEQSG----SNKKAKRVWISSQTEEAIREGILNAKDIEEYDSLARAAYSRAKEDWLFGMN 179 Query: 176 MTRAYTILGRNAGYQ-------GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI 228 +R YT L V+++GRV T VLGLVV R++EI NF+ K + + A Sbjct: 180 FSRIYTCLYGRKLSNFLKESKTSVIAIGRVMTCVLGLVVDREQEIRNFMPKKHYGITATF 239 Query: 229 -VTPADERFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 + ++ + W P + + D+E + + R AE V+ R+ G P + K + E Sbjct: 240 LSSVSNLLYKGKWVPQNKKDDKEADDEEKYISREEAEQVIERLKGHPGKIKKVEVKTKKE 299 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 PL F+L+ LQ EA K+F L L+I Q LYE KLITYPR+D R + + Sbjct: 300 QPPLLFNLAELQSEANKKFKLPVDKTLEIAQWLYE-KKLITYPRTDSRVISTDVLEEVPK 358 Query: 347 VMNAISVH--APDLLPQPVVDPDIR-----NRCWDDKKVDAHHAIIPTARSSAI-NLTEN 398 V+N I + D + + D++ R D+ KV H+AIIPT ++ + EN Sbjct: 359 VLNGIYKNPEYRDYVLKIKEMGDLKVTKSTKRYVDNSKVTDHYAIIPTYVNAETVRMDEN 418 Query: 399 EAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK--ERD 456 VYNLI +++L F P AV+ +E + FV+ A+ L EAGW+ + ++D Sbjct: 419 TKNVYNLIVKRFLAIFFPPAVYNTVRVETVVNNEIFVSNAKTLKEAGWKEVYEVSAPKQD 478 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 EE P+ ++ K + + + E+ E++T+PP +TD +L+ M +F++D++L++ + Sbjct: 479 EELTEAPIHLLVKNEAVEAKDFELEEKETKPPSRYTDGSLIITMEKAGKFIEDEELREQI 538 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLP---EMATRPDMT 571 + G+GT ATRAGII+ L G++ + + T G+A+ + P +T Sbjct: 539 KTC-GIGTSATRAGIIKKLSDIGYIKINPKTQVVTPTLKGEAIVELVRRTARELLSPSLT 597 Query: 572 AHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQ 613 A WE L I K+ + F + L + + I++ KR Sbjct: 598 ASWEKGLAMIENKETTAEIFEEKLCVYINKTINKVKRGESNI 639 >UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0_STRPF Length = 577 Score = 506 bits (1302), Expect = e-141, Method: Composition-based stats. Identities = 189/613 (30%), Positives = 307/613 (50%), Gaps = 47/613 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A IA ++ RK +G+ E GNG +V+WC+GHL++ A PD D ++ + Sbjct: 5 MKLVIAEKPSVAVTIAKIIGARTRK-NGYYE-GNGYIVSWCVGHLIQMASPDKIDEKWKK 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 W + +LPI+PE++ + S KQ V+K+ L + +++A D REG+L+ V + Sbjct: 63 WTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNINIVINACDAGREGELIFRLVYNQ 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++++QR I+ + +A+E L+ +F L SA ARA ADWL G+N++R Sbjct: 123 AKC----KKKIQRLWISSMENEAIEDGFRNLKDGEKFEDLYRSASARAIADWLVGMNLSR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 Y+ + + SVGRVQTP L L+ +RD EI F + ++ V Sbjct: 179 LYSCIYKE-----TYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYG--------- 224 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + D R+ +AE ++N + ++T DK S P+ L+ LQ Sbjct: 225 ------GLKLVSDRIDRI---EVAEQLLNLLED-EIVITEVEDKEVSTKPDKPYDLTTLQ 274 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA K FG SA + L++ Q LYE KLITYPR+D RYL ++ ++ + Sbjct: 275 REANKYFGYSANDTLNLAQALYE-KKLITYPRTDSRYLTDDMVNTMKELLEGLEEDFK-- 331 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT--ARSSAINLTENEAKVYNLIARQYLMQFCP 416 ++ ++ KV H+AIIPT A +L++ E+KVYNLI + L Sbjct: 332 -----LNKSNFKSIFNSSKVTDHYAIIPTISGIGKAKDLSDKESKVYNLIKDKLLASCSD 386 Query: 417 DAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCE 476 + I + K F A + + + G+ L K +E LP V GD++ Sbjct: 387 NLKESSRKIRYEYDKFNFNASGKTIIDEGYTKYL--KAYGKEKQENELPDVKTGDKIKLT 444 Query: 477 KGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLF 536 + E+ T+ P H+ + TLL AM DKD++ GLGT ATRAGIIE L Sbjct: 445 SKNISEKFTKAPSHYNEDTLLKAMENAGVESLDKDIEV---ERKGLGTPATRAGIIENLI 501 Query: 537 KRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + + + + + T+ G L + + + T+ WE L +I+ + +DF++ + Sbjct: 502 HKELIRRDKKNLLVTEKGNRLVSIVEDKFKSAETTSEWEMKLAKINSGEVDKEDFLREIE 561 Query: 597 GTLYQLIDQAKRT 609 ++ +L+D+ K Sbjct: 562 DSIRELVDRYKNN 574 >UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_SYNAS Length = 769 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 131/694 (18%), Positives = 248/694 (35%), Gaps = 108/694 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + + L V GH+ + + Sbjct: 5 LIIVESPTKVKTLKKYLGA-------------DYEVLASKGHIKDLPKKTLGID------ 45 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P + K + +K+ S I A DPDREG+ + + + ++ Sbjct: 46 ----PQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEIKA- 100 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 K +++ R L NDL + AI+ + R D L G ++ Sbjct: 101 --KNKEIYRVLFNDLTKNTILDAINHPGKLD--FNKYEAQQTRRILDRLVGYQISPILWE 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + ++ R+EEI+ F+ ++++ + + F A Sbjct: 157 KVKRG-----LSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIK 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQ-------------------PAIVTSYNDKR 283 ++ ++ + A +V+R+SG +V+ K Sbjct: 212 ITG------KKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKE 265 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRY 335 + + PF+ S LQ EA++ SA+ + QKLYE LITY R+D Sbjct: 266 VKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVR 325 Query: 336 LPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN- 394 + E+ + + + P + R K DAH AI P++ + Sbjct: 326 IAEDALKEVRSYIR-------ENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQK 378 Query: 395 ----LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL 450 L+ ++ ++Y LI +++ A++ + +E+ F A+ L G+ + Sbjct: 379 IKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVY 438 Query: 451 GSKERDEE-----NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 + D+E G LP + +G+ L K ++ TQPP F++A+L+ + Sbjct: 439 TEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEE--- 495 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA 565 G+G +T A I+ + R + + H T+ G + L + Sbjct: 496 --------------QGIGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNF 541 Query: 566 ---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK---RTPVRQ--FRGI 617 TA E+ L I E + + + +Q + + +A+ + R+ + Sbjct: 542 PKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDL 601 Query: 618 VAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + K K A + PA + Sbjct: 602 ICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNI 635 >UniRef50_B1VJ64 DNA topoisomerase n=9 Tax=Gammaproteobacteria RepID=B1VJ64_PROMH Length = 772 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 234/671 (34%), Positives = 356/671 (53%), Gaps = 33/671 (4%) Query: 1 MRLFIAEKPSLARAIADVLPKP--HRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 MR+FIAEKPSLA+AI + L K G+ + G+ VVTWC+GH+LE + P YD +Y Sbjct: 1 MRVFIAEKPSLAKAIFEGLGGNPNTEKKKGYFQHGDD-VVTWCVGHMLELSDPQDYDEKY 59 Query: 59 ARWNLADLPIVP-EKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A W DLPI + + Q +I + +A IV+AGDPD EG LLV+E+LD Sbjct: 60 ASWRFGDLPIKTVFPPTYKIKKETAAQTKIILSLIDQAKTIVNAGDPDEEGCLLVNEILD 119 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y + ++ V+R L++DLN V++A+ L+ N +F + SAL+R+ D +G N+T Sbjct: 120 YAK----NKKPVERILVSDLNLAPVKKALADLQPNEKFRGMSNSALSRSLLDQSFGYNLT 175 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R T+ GR GYQGVL+VGRVQ+ VLGLV R +N ++++ A I + Sbjct: 176 RGCTLKGREKGYQGVLNVGRVQSAVLGLVNMRTLANQNHNESFYYDIYALIEM-NGHQVK 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A +Q ++ + D++ RL+ A+H+ +SGQ VT K E+ PLP +LS L Sbjct: 235 AKYQTTDNDQI--DDKRRLISEAQAKHITEIVSGQAVKVTIAATKAENTKPPLPLNLSTL 292 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q AKRFG + Q LDI Q LYETHKL+TYPR+D RYL +EH+ + + A+ P+ Sbjct: 293 QQICAKRFGYAPQETLDIMQSLYETHKLLTYPRTDNRYLSDEHYYQANDIAQAVIGTLPE 352 Query: 358 LLPQ-PVVDPDIRNRCWDDKKVDAHHAIIP-TARSSAINLTENEAKVYNLIARQYLMQFC 415 L +D +++ ++ K++AHHAI+P T S I L E E VY L++ ++ F Sbjct: 353 LASTVEHMDKVQKHKAFNASKIEAHHAIVPTTKDGSNIQLNEKEKNVYRLVSLYFIGLFY 412 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEND----GTPLPVVAKGD 471 PD++ K + DI F A L ++GW +L + +E + L + D Sbjct: 413 PDSIRDKTKVHFDIKGNTFTATQSVLVQSGWESLGKDSDEEETEEPEKLDFDLSTLKFND 472 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD-------GLGT 524 +CE V ++ T PP++FT +TLL+AMT A+F+ D +L+KIL A D +GT Sbjct: 473 NGVCETANVDKKPTLPPKYFTASTLLAAMTRAAKFIDDPELRKILEAKDEGSTDQGSIGT 532 Query: 525 EATRAGIIELLFK-RGFLTKKGRY------IHSTDAGKALFHSLPEMATRPDMTAHWESV 577 EATRAGI++ L + G ++ + +T G+ +LP+ T+PD++A W Sbjct: 533 EATRAGILKKLSENTGLISIEKEKGYSELVWKTTKQGQEFCAALPDEITKPDISARWAEK 592 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF-RGIVAPGSGGS-ADKKKAAPRK 635 I + + DF++ + +LI + + G P K+K Sbjct: 593 QALIKKGELTVADFIKETDSYIKELIAELDANGINITANGTPCPVCQKGFLIKRKGQNGF 652 Query: 636 RSAKKSPPADE 646 P + Sbjct: 653 FWGCSCYPECK 663 >UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID=C9BSW4_ENTFC Length = 801 Score = 502 bits (1294), Expect = e-140, Method: Composition-based stats. Identities = 172/659 (26%), Positives = 311/659 (47%), Gaps = 29/659 (4%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAY 54 M+ + +AEKPS A+A A+ + ++ +G+ E + +T+ GHL++ P AY Sbjct: 60 MKTVILAEKPSQAKAYAETF-QQQKRHEGYYEISDPLFAGEVTITYGFGHLVDMVAPGAY 118 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + R+A+W+L +LPI PE ++ + Q +++KR L A I+ A D DREG+ + Sbjct: 119 EERWAKWSLENLPIFPETFRYEVPMDKRAQFSIVKRELQSADTIIIATDGDREGEAIAWS 178 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 ++ A K + R IN L +A+ L+ + P A AR ADWL G+ Sbjct: 179 IIRQAN-AFSKEKNYLRLWINSLEKEAIYEGFKNLQPGKNYFPKYKEAQARQNADWLIGM 237 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N + Y++L + G G S+GRVQTP L ++ + EEI++F + +FE + I T + Sbjct: 238 NGSPLYSLLLQRKGIDGSFSLGRVQTPTLYMIYQLQEEIKHFKKETYFEGEGLITTNKGQ 297 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 F+ P +A + ++ + E + + Q + K + +P FSL Sbjct: 298 -FSGKIVPKKAFKTQEELTKEI------EKLGAHLGKQNGRILEVTKKEKRLHSPRLFSL 350 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S+LQ + + SA+ LD Q LYE+ K ++YPR+D Y+ E + Sbjct: 351 SSLQTKMNQLMKASAKATLDAAQGLYES-KFLSYPRTDSFYITENEHQYLVKHLQNYKKF 409 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQY 410 + + + R D KKV HHAIIPT L++ + +Y + R Sbjct: 410 LG-IEEVQTTEIKAKKRYVDAKKVQEHHAIIPTKTIPTPARFAKLSKLQQAIYLQVLRTT 468 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + F D ++ + + + + K + + + GW+ +L K + +E LP + + Sbjct: 469 VAMFAADYIYEETTVMTGVQQLKLKSIGKIPLQQGWQEILRIKSKKKE--AQTLPPIVEN 526 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 +E + + +E++TQPP+ +T+ TL++AM + + + + ++IL+ +G+GTEATRA Sbjct: 527 EEAEV-ELKSMEKETQPPKPYTEGTLITAMKTAGKTLDNDEAQEILKEVEGIGTEATRAN 585 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSL--PEMATRPDMTAHWESVLTQISEKQCRY 588 IIE L ++ ++ I T G L ++ + T +MTA WE L +I +++ Sbjct: 586 IIENLKQKHYIEVNKNEITVTPKGITLCKAVANEPLLTSAEMTARWEGYLRKIGKQEGTP 645 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 F++ + + L+ + + G+ K + + P + Sbjct: 646 SVFLENIKKFILHLLAEVPNQIDKVDFS---DEISGTRQIKAMEKKNDQLGRCPKCKKG 701 >UniRef50_B9KGJ1 DNA topoisomerase III TraE n=4 Tax=Campylobacterales RepID=B9KGJ1_CAMLR Length = 676 Score = 502 bits (1294), Expect = e-140, Method: Composition-based stats. Identities = 203/676 (30%), Positives = 342/676 (50%), Gaps = 50/676 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 MRLFIAEKP L RAIA+ L +K +G+I+ G+ ++TW GH+L A P+ Y+ ++ Sbjct: 1 MRLFIAEKPELGRAIAEGLDGNVKKFEGYIQKGDN-LITWAFGHILRLATPEFYNEKWKL 59 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDY 118 WNL DLP+ ++++ P + KQL +I + + IVH GD D EGQ+L+DE++ Y Sbjct: 60 WNLNDLPLDIKEFKYIPINNSKKQLEIICKLIKNDQVDSIVHCGDADDEGQILIDEIIQY 119 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ V R LINDL P+AV+ I +++ NS+F + AR++ADW+ GIN+TR Sbjct: 120 ----SKTKKPVFRVLINDLTPKAVKAEISKMKPNSQFKGMSERGFARSQADWIVGINLTR 175 Query: 179 AYT-ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 AYT + + +G++ VL++GRVQTP+LGL+ RD E ENF + D++ + + F Sbjct: 176 AYTSVAQQKSGFREVLTLGRVQTPILGLITARDNEYENFKSMDYYSLLGKFEI-NGKVFN 234 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + E ++ +A+ + + ++ S +++ E PLP+SL L Sbjct: 235 ARLKTEEK----------IIDENIAKQIKEININKTVLI-SVFKEKKKEYPPLPYSLLIL 283 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q E AK +G S L+I Q L E +K ITY RSDC+YLPE F ++N+I ++ + Sbjct: 284 QAECAKLYGYSPDKTLEITQNLREKYKAITYNRSDCQYLPETMFEQAPNILNSIKLNIKN 343 Query: 358 L-----LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYL 411 L D I+++ ++DK + AH+ IIPT + L E E +Y LI ++++ Sbjct: 344 NDSDLSLLLEKSDLSIKSKAFNDKNISAHYGIIPTQNNFDCGLLKEEEKNIYILIVKRFV 403 Query: 412 MQFCPDAVFRKCVIELD-IAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT---PLPVV 467 +QF + +E+ K F G+R + + D + ++ Sbjct: 404 IQFFKPREYEVTNLEIQTYDKSVFGTSQSKNISEGFRKFFKQSDEKDNEDTNNHLDISLI 463 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD------- 520 + E+ ++QT+P ++T +LL + +A++V+D+ +KK+L D Sbjct: 464 ENNSACKIKDIEIEKKQTKPRPYYTMDSLLKDLNSVAKYVKDEKIKKLLIEKDKDKKGEN 523 Query: 521 -GLGTEATRAGIIELLFKRGFLTK---KGRYIHSTDAGKALFHSLPEMATRPDMTAHWES 576 G+GT ATR+ I+ L ++G++ K + + ST G+ L PE PDMTA W Sbjct: 524 GGIGTPATRSTHIKNLIEQGYIEVSKDKKQVVKSTKKGRLLISLAPETLKYPDMTALWFE 583 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT-------PVRQFRGIVAPGSGGSADKK 629 I + + +DF+Q ++ + I + K + + + P + Sbjct: 584 QQKMIEQGTIKKEDFLQNILKEVNSEILKIKENGSMNQFSQLSKEKQYSCPECKNGYLIR 643 Query: 630 KA--APRKRSAKKSPP 643 + Sbjct: 644 RKNTKGTYWWGCSEYK 659 >UniRef50_C7GFF6 DNA topoisomerase n=11 Tax=Firmicutes RepID=C7GFF6_9FIRM Length = 1317 Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats. Identities = 190/706 (26%), Positives = 322/706 (45%), Gaps = 61/706 (8%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A +L + DG+IE + V+TWC+GHL+E P+ YD +Y RW Sbjct: 5 LIITEKPSVAQEFARILGV-SGRNDGYIE-NDKYVITWCVGHLVEMVYPEEYDEKYKRWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +PE+++ P V+KQ + + R L + AGD +EGQ + + + + Sbjct: 63 LEDLPFLPEEYKYNVIPDVSKQYDTVHRMLFREDIETVYWAGDAGKEGQTIEENIRRFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + P ++ R I+ + + R I + +E+ L S + R D+ GIN +RA Sbjct: 123 VRPGMKE--LRVWIDSQTEEEILRGIREAKPMAEYDNLAKSGIMRTIEDYAMGINFSRAM 180 Query: 181 TILGRNAGYQG-------VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA- 232 ++ ++VGRV T VLG+VV R+ EI NF F+ V + Sbjct: 181 SVKYGKLLNDAAATKSYTAIAVGRVMTCVLGMVVIREREIRNFAETPFYRVVGGFLPEGA 240 Query: 233 --DERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 +E TA W+ + ++ +E R AE+++ + G+ A+V S + Sbjct: 241 ETEETVTAEWKAVNGSKYFESPLLYKENGFKKRESAENLIGELDGKQAVVKSLERGTSRK 300 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 APL F+L+ LQ E +KR+ +S L + Q LYE KL TYPR+D R L Sbjct: 301 KAPLLFNLAELQAECSKRYKISPDETLQVAQDLYE-KKLTTYPRTDARVLSTAVAKEIGK 359 Query: 347 VMNAISVHAP------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENE 399 +N + + P +L + R + DD K+ H+AIIPT + + +L++ + Sbjct: 360 NLNRLKTYEPTKTYTERILKEGTYRNIARTQYTDDSKITDHYAIIPTGQLTELGSLSDLQ 419 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL---GSKERD 456 +VY+L+ R++L F P A + + + + + A A+ L G+ ++ G+ E Sbjct: 420 RRVYDLVVRRFLSIFYPAAEYETIKLVVQVGAEQLFASAKVLKNPGFLEIMGRPGNDENK 479 Query: 457 EENDGTPLP---VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 EE L + GD L + E+ E +T PP+ +T +++ AM + +++++L+ Sbjct: 480 EEESAGLLKLAGQLKTGDPLKVDGYEIKEGKTAPPKRYTSGSMVLAMENAGQLIEEEELR 539 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLP---EMATRP 568 + ++ + G+GT ATRA II L + G+L + + G+ +F + P Sbjct: 540 EQIKGS-GIGTSATRAEIIRKLVRIGYLNLNQKTQVLSPEAIGEMVFEVVSMTVPALLNP 598 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV----------------- 611 MTA WE L I+ +D+ L + + + Sbjct: 599 KMTASWEKGLDGITRGTVIMEDYRSKLEDFIRKETVSMIEHDLTGNLAARIHPFVGKGGR 658 Query: 612 ----RQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 ++ V P GG + + KK + G IA Sbjct: 659 GLAAKKKIEAVCPVCGGEMETTPFGYGCSNYKKDGSGCKFSIGTIA 704 >UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms RepID=TOP1_VIBCH Length = 876 Score = 501 bits (1291), Expect = e-140, Method: Composition-based stats. Identities = 130/692 (18%), Positives = 241/692 (34%), Gaps = 102/692 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQP----------- 51 L I E P+ A+ I L K +V +GH+ + Sbjct: 5 LVIVESPAKAKTINKYLGK-------------DFIVKSSVGHVRDLPTAGQTATPTGKAA 51 Query: 52 -------------DAYDSRYARWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEA 95 + + + + P + Q P K + +++ +A Sbjct: 52 AASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDA 111 Query: 96 SEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEF 155 + A D DREG+ + + + + ++ +R + N++ A+++A + + Sbjct: 112 DSVYLATDLDREGEAIAWHLREIIG---GDEKRYKRVVFNEITKNAIQQAFKQPGELN-- 166 Query: 156 VPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEN 215 + + AR D + G ++ LS GRVQ+ + L+V R+ EI+ Sbjct: 167 MDGVNAQQARRFMDRVVGFMVSPLLWKKVARG-----LSAGRVQSVAVKLLVEREREIKA 221 Query: 216 FVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI 275 FV ++F+++ A +T + F + + ++ A V ++ Sbjct: 222 FVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKP------VNETEALAAVAALNKAQYE 275 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V DK + PF S LQ A+ R G + + + Q+LYE ITY R+D Sbjct: 276 VCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEA-GYITYMRTDSTN 334 Query: 336 LPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS----S 391 L E + + LP + +AH AI P+ + Sbjct: 335 LSAEAVENLRGYI--TKHYGEAYLPSQPNVYGSKQ-----NAQEAHEAIRPSDVTVTADD 387 Query: 392 AINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG 451 + + K+Y LI Q++ A + + + A+ AK R L GW + Sbjct: 388 LEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQR 447 Query: 452 SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKD 511 ++E+ LP V GD L + + T+PP +T+A L+ + Sbjct: 448 PLGKNED---QILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEK--------- 495 Query: 512 LKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRP 568 G+G +T A II + RG++ R + G+ + L E Sbjct: 496 --------RGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNY 547 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--------RQFRGIVAP 620 D TA E L QI+E + + + + ++ A++ I+ P Sbjct: 548 DFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCP 607 Query: 621 GSGGSADKKKAAPRKRSAKKS---PPADEVGS 649 + A+ PP + + Sbjct: 608 TCSRPMGIRTASTGVFLGCSGYGLPPKERCKT 639 >UniRef50_Q8CS09 DNA topoisomerase n=2 Tax=Staphylococcaceae RepID=Q8CS09_STAES Length = 718 Score = 501 bits (1290), Expect = e-140, Method: Composition-based stats. Identities = 185/685 (27%), Positives = 316/685 (46%), Gaps = 53/685 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIE-----CGNGQVVTWCIGHLLEQAQPDAYDS 56 L IAEKP+ + + L DG+IE +VTWC+GHL++ A + YDS Sbjct: 3 ILIIAEKPNQVKKYVEALGNSFNNKDGYIELESELFDKKVIVTWCVGHLIQLAHMEDYDS 62 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE---ASEIVHAGDPDREGQLLVD 113 +W+ LP +PE + + +KQ +IK SEI+ A DPDREG+ + Sbjct: 63 NLKQWSKDTLPFIPEDFIFKVSDYGSKQFKIIKELCENLNSDSEIIIATDPDREGEAIAR 122 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 VL+ + K +++R N P+ ++ A L+ + + A AR+ ADWL G Sbjct: 123 YVLNKIPCT--KNLKLKRLWANTQEPEGLKLAFKNLKDADDTYRFYLEAEARSIADWLVG 180 Query: 174 INMTRAYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 +N TR T+ + G GV SVGRVQTP L +V +R+ EI+NF +K ++E+ A Sbjct: 181 MNFTRYVTLEMKQLGIDEGVFSVGRVQTPTLYMVYKRNNEIKNFESKTYYEMVAKDKENE 240 Query: 233 DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPF 292 + F + + DE + L+ ++ G+ + + + + AP F Sbjct: 241 NAVFKSEHKFDSI-----DEFEQFLNEN---NLNCECEGE---IKEISISEKRKVAPNLF 289 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 L +Q A +++G + L I Q LY+ ++YPR+DC + F ++ Sbjct: 290 KLGGIQKVANQKWGYTLDKTLSIVQSLYD-KGYLSYPRTDCSLITHSEFEYLKDNFSSYC 348 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL----TENEAKVYNLIAR 408 + Q ++P R + +D KV H+AIIPT + ++ +++E K+Y+ + + Sbjct: 349 KLLNIEIEQKNIEP--RTQYVNDSKVLEHYAIIPTKQIPENDVYNNFSDDEKKIYDEVVK 406 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + ++ F D ++ + I L I +F E GW+ L ++ + LP Sbjct: 407 RTMLMFMEDYIYSETKIVLCIENVEFKLTGNVAKEQGWKLL---DSENKNSKEKLLPNYK 463 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLS---AMTGIARFVQDKDLKKILRATDGLGTE 525 + ++L E T+PP++ T+ATL M ++F+++++LK L+ G+GT Sbjct: 464 ENEKLSL-NLVPKELNTKPPKYLTEATLGGEGGLMENCSKFIENEELKGNLKEVHGIGTP 522 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE-MATRPDMTAHWESVLTQISEK 584 ATR+ I++ L RG+L K +++ T G L +L +MTA+WES L ISEK Sbjct: 523 ATRSSIVKSLIDRGYLETKKKHLMITPKGTLLCSALENTNLVSVEMTANWESTLKDISEK 582 Query: 585 --QCRYQDFMQPLVGTLYQLI------------DQAKRTPVRQFRGIVAPGS--GGSADK 628 + R +F+ + + Q+I D+ + Q P G Sbjct: 583 GHRIRQNEFIDSIKQYIKQMINSDNKLLKLESNDKNIEKAIEQSTICNCPKCSNGRIKKL 642 Query: 629 KKAAPRKRSAKKSPPADEVGSGAIA 653 + A + D + G I+ Sbjct: 643 LSKNKKLFYACSNKDCDFIIFGMIS 667 >UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_PELUB Length = 863 Score = 501 bits (1289), Expect = e-140, Method: Composition-based stats. Identities = 134/691 (19%), Positives = 244/691 (35%), Gaps = 98/691 (14%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L + E P+ A+ I L + +V GH+ + + Sbjct: 1 MNLVVVESPAKAKTINKYLG-------------DDYIVLASYGHIRDLPSKNGSVDPENN 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + K L I +S+I+ A DPDREG+ + V +YL Sbjct: 48 FKME----------WEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVKEYLN 97 Query: 121 LAPEKR-QQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + ++R + N++ +AV I+ R L + +AR D+L G N++ Sbjct: 98 EKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPL--LVDAYMARRALDYLVGFNISPI 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 G S GRVQ+ L L+ R+ EIE F ++F+ + A Sbjct: 156 LWTKL-----PGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSDKNSILAS 210 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 + E+ ++ + + + + + + K + + PF+ S LQ Sbjct: 211 ITQLNDKKI---EKFSFKNKAEIDKAMEEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQ 267 Query: 300 EAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 ++ R G A + I QKLY ET LITY R+D L + + + Sbjct: 268 VSSGRLGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIK--N 325 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + +P + +AH AI PT A + L+ ++ K+Y+LI Sbjct: 326 EFGDEYVPDNAASYSGKKA---KNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIW 382 Query: 408 RQYLMQFCPDAVFRKCVIEL--DIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 + L A F + I + D A + G+ ++ ++D +D LP Sbjct: 383 SRALSSQMKPAQFDRNTITISSDDNGTICKASGSVIKFDGFLKVMKDTKKD--DDEDILP 440 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 + KG + E + TQPP +++A+L+ + + +G Sbjct: 441 EMNKG-PVNIESLLDEQHFTQPPPRYSEASLVKKLEELG-----------------IGRP 482 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQIS 582 +T A II ++ RG+ + H TD GK + L ++ + TA E+ L I+ Sbjct: 483 STYASIISVISTRGYAETINKRFHPTDRGKLISAFLEKLFSKYVDYNFTASLENQLDDIT 542 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI--------------------VAPGS 622 + + ++ Q + K R+ + Sbjct: 543 TGKEGWIKVLELFWKDFNQNVSDVKEKRTREVLDLLNDSLGSLIFERDADGNINRQCKLC 602 Query: 623 --GGSADKKKAAPRKRSAKKSPPADEVGSGA 651 G + K + P + Sbjct: 603 DSGSLSLKNSFRGGAFIGCSNYPDCKFTRPL 633 >UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_SOLUE Length = 934 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 136/671 (20%), Positives = 249/671 (37%), Gaps = 91/671 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K VV +GH+ + + D + Sbjct: 5 LVIVESPAKAKTINKYLGK-------------QYVVKASLGHIKDLPKRDLAVDVEHGFE 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + K + ++ +I A DPDREG+ + + + L+ Sbjct: 52 P----------RYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAICFHLQEELRSK 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + R + N++ +AVE+A + + L + AR D L G ++ Sbjct: 102 KDGPA-FFRVMFNEITKKAVEKAFE--KPLQVNTNLVDAQQARRVLDRLVGYKISPLLWD 158 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQT L ++V R+ EI F K+++ V ++ + Sbjct: 159 KVRRG-----LSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRLIK 213 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + DE L ++ + +V ++SG IV S + + + PF S LQ +++ Sbjct: 214 A------NDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSS 267 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ S + + + Q+LYE LITY R+D ++ + + Sbjct: 268 RKLRFSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVR-------HY 320 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + P + P + DAH AI PT+ + + L E+E K+Y LI + Sbjct: 321 IGERYGAPFLPPAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNR 380 Query: 410 YLMQFCPDAVFRKCVIELDIA-----KGKFVAKARFLAEAGWRTLLGS----KERDEEND 460 ++ A+F + I++ + F A G+ + + D+E Sbjct: 381 FVASQMMPALFDQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEEL 440 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 LP+V +G+ L E + T+PP + +ATL+ + D Sbjct: 441 KHRLPLVTEGEVLRLEAIRPEQHFTEPPPRYNEATLVKRLE-----------------AD 483 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESV 577 G+G +T A I+ + +R ++ K+ T+ G + L + TA E Sbjct: 484 GVGRPSTYATILSTIQEREYVNKEAGRFTPTELGMVVTDLLLESFDDIFDVKYTARMEEE 543 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGSADKKKAA 632 L +I E + ++ M G + + A+ + + ++ G K Sbjct: 544 LDEIEEGKLDWRAAMSEFYGRFDKDLKHAEEHMTDIKRMEKPTDLICEKCGRPLVIKWGK 603 Query: 633 PRKRSAKKSPP 643 A P Sbjct: 604 HGSFIACTGYP 614 >UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FRC6_SORC5 Length = 864 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 135/721 (18%), Positives = 250/721 (34%), Gaps = 135/721 (18%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L NG V GH+ + + + Sbjct: 5 LVIVESPAKAKTIKKYLG-------------NGYEVFASKGHVKDLPKKQNAVDVQNDFA 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + K L +K +A E++ A DPDREG+ + + + ++ Sbjct: 52 E----------TYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIK-- 99 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + +V R +++ + V+ + R E L + AR D + G +++ Sbjct: 100 -NPKLKVARVEFHEITKKGVDHGVHNPRKLDE--NLYDAQRARRVLDRIVGYDVSALVWS 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI---VTPADERFTAI 239 LS GRVQ+ L L+V R+ E+E FV ++++ + + P F A Sbjct: 157 KL-----AFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAK 211 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ ++ + + +A V + V + + + P P++ S LQ Sbjct: 212 LASADG------KKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQ 265 Query: 300 EAAKRFGLSAQNVLDICQKLYETH---------KLITYPRSDCRYLPEEHFAGRHAVMNA 350 +A A+ + I Q LYE LITY R+D + ++ A V+ Sbjct: 266 DATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVV-- 323 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNL 405 + + +P+ DAH AI PT+ + L + + K+Y L Sbjct: 324 AKRYGKEFVPE-----RPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKL 378 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAK---------GKFVAKARFLAEAGWRTLLGSKER- 455 I +++ AV+ + +E+D+A A R L AGW + ++ Sbjct: 379 IWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEF 438 Query: 456 -----------------------------------DEENDGTPLPVVAKGDELLCE--KG 478 EE+ LP + +G+ L Sbjct: 439 AGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGV 498 Query: 479 EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKR 538 ++ TQPP + + +L+ + G+G +T A II + +R Sbjct: 499 ITDQKFTQPPPRYNEGSLVRELEK-----------------RGIGRPSTYAEIISKVQQR 541 Query: 539 GFLT-KKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 ++ + G T GK + L P+ TA E L + + + ++ Sbjct: 542 AYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKS 601 Query: 595 LVGTLYQLIDQAKR----TPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 + +D++K+ P + IV G KK + + P + Sbjct: 602 FYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRD 661 Query: 651 A 651 Sbjct: 662 L 662 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 499 bits (1286), Expect = e-140, Method: Composition-based stats. Identities = 163/712 (22%), Positives = 285/712 (40%), Gaps = 104/712 (14%) Query: 3 LFIAEKPSLARAIADVL--PKPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPDAY 54 L IAEKP++AR IA L +P RK G F G +V +GHL A Sbjct: 4 LIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPK--- 60 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 ++ + + D+ VP + + + + A E V A D D EG+++ Sbjct: 61 -TKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYT 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L Y + +R + L + + +A L S F + + +AR DW +G+ Sbjct: 120 ALKYACGVDPSKA--KRMKFSALTKKDLLKAWYNLESTINF-GMADAGIARHVLDWYWGV 176 Query: 175 NMTRAYTILGRNA-GYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 N++RA T + A G VLS GRVQ P L +V R++EI+NF ++ +K + Sbjct: 177 NLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLE-KNG 235 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +++TA++ E+ R+L A+ +V PA V + K+++ P+PF Sbjct: 236 QQYTAVY-----------EKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFD 284 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 L LQ EA FG S + L++ QKLYE L +YPR+ + LP+ R + N + Sbjct: 285 LGTLQREAYSAFGYSPKKTLELAQKLYE-RGLTSYPRTSSQKLPKN-LNFRSILQNLAKL 342 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI-NLTENEAKVYNLIARQYLM 412 ++ + K AH AI PT LT++EA +Y+LI R++L Sbjct: 343 PEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEANLYDLIVRRFLA 402 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F AV + ++ +F+ + GW + G + +E LP +G+ Sbjct: 403 LFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDE---AILPAFKEGEP 459 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + + + +++T+PP ++ A ++ M + +GT+ATRA I+ Sbjct: 460 VKVLQIKREKKKTKPPARYSPAAVIKRMEDLG-----------------IGTKATRAQIL 502 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQ 589 E L+ RG++ K + I T G + +L ++T +E + +I + Sbjct: 503 ETLYSRGYIEGKKK-IKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKD 561 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFR---------------------------------- 615 ++ L +++ Q K + + Sbjct: 562 RVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKELSETEEKDV 621 Query: 616 -------------GIVAPGSGGSADKK--KAAPRKRSAKKSPPADEVGSGAI 652 P GG + + ++ + P V + Sbjct: 622 KKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLL 673 >UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepID=D1B572_SULD5 Length = 694 Score = 499 bits (1286), Expect = e-139, Method: Composition-based stats. Identities = 131/668 (19%), Positives = 245/668 (36%), Gaps = 86/668 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I + L K V GH+ + + + + Sbjct: 8 LIIVESPTKAKTIKNFLGK-------------NYTVVASKGHIRDLPKSS-FGIKIDNQT 53 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + + IK EA ++ A D DREG+ + + + Sbjct: 54 FIP--------EYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFHIATAIGKD 105 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P + + R + +++ A+ A++ R E + AR D + G ++ + Sbjct: 106 P---KSLPRIVFHEITKNAITHALENPRILDE--SSINAQQARRLLDRIVGYKLSPLLSS 160 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L +VV R++EI F ++F+ + A A Sbjct: 161 KIQKG-----LSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFNK----TIEASLVE 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E + E+ + ++ A + ++ + V K S F S LQ A+ Sbjct: 212 FEGEKI---EKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSAS 268 Query: 303 KRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G S + + + Q LYE +ITY R+D + +E + +S + Sbjct: 269 SALGYSPKKTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQI--LSQYG 326 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQY 410 LP+ +++ +AH AI PT ++ L +E K+Y LI ++ Sbjct: 327 KTYLPEKARFYANKSK----GAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRF 382 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L +A F + + GKF A R L G+ + G ++D+ LP +A Sbjct: 383 LASQMNNARFESQTLIFESQSGKFKASGRKLLFDGFYKVYGDNDKDK-----LLPDLALK 437 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 E+ K + + T+PP +++A+L+ + + +G +T A Sbjct: 438 QEVTLSKLDANQHFTEPPSRYSEASLIKKLESLG-----------------IGRPSTYAP 480 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 I +L R ++ + + I T+ + L + T+ E L I+E + Sbjct: 481 TISVLSARDYINIEKKQIVPTEVAFQVTELLEQHFPQIVDSSFTSTMEERLDLIAEDKED 540 Query: 588 YQDFMQPLVGTLYQLIDQAKRTPVRQ----FRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 +Q + + + K Q F G + P G ++K + A + P Sbjct: 541 WQAILWNFYEPFDAQVAKGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYP 600 Query: 644 ADEVGSGA 651 + Sbjct: 601 TCKYTQNL 608 >UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa RepID=TOP3A_HUMAN Length = 1001 Score = 499 bits (1285), Expect = e-139, Method: Composition-based stats. Identities = 140/694 (20%), Positives = 247/694 (35%), Gaps = 94/694 (13%) Query: 3 LFIAEKPSLARAIADVLPKPH-RKGDGFIECGNGQ-------------VVTWCIGHLLEQ 48 L +AEK A+ IAD+L R+ +G + V+T GHLL Sbjct: 37 LCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAH 96 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQPRPSV-TKQLNVIKRFLHEASEIVHAGDPDRE 107 + ++ +W + ++ E + P ++R + +V D DRE Sbjct: 97 ----DFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDRE 152 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + E++ + A + QV R +++ P AV A + L + V + R Sbjct: 153 GENIGFEIIHVCK-AVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVS--DAVDVRQE 209 Query: 168 ADWLYGINMTRAYTILGRNAGYQ----GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 D G TR T+ + + ++S G Q P LG VV R + I+ FV + F Sbjct: 210 LDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHR 269 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDK 282 +K + + + RL + + P A V K Sbjct: 270 IKVT------------HDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSK 317 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 +S+ P L+ A+++ ++A+ + I +KLY T I+YPR++ P + Sbjct: 318 PKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLY-TQGYISYPRTETNIFPRDLNL 376 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 V Q +++ +K AH I PT ++ NL +E ++ Sbjct: 377 TVL-VEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTN--NLQGDEQRL 433 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGT 462 Y I R +L DA ++ +E+DIA+ +FVA + + + + Sbjct: 434 YEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPY----DHWSDK 489 Query: 463 PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGL 522 LPV +G E+V+ +T PP+ T+A L++ M G+ Sbjct: 490 ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEK-----------------HGI 532 Query: 523 GTEATRAGIIELLFKRGFLTKK-GRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVL 578 GT+AT A IE + R ++ + G L M ++PD+ A E+ L Sbjct: 533 GTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADL 592 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI--------------------- 617 I + + ++ V Q+ +A + + Sbjct: 593 KLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMP 652 Query: 618 ----VAPGSGGSADKKKAAPRKR-SAKKSPPADE 646 P K + P Sbjct: 653 EPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECR 686 >UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola AmH RepID=B9L7D9_NAUPA Length = 728 Score = 499 bits (1285), Expect = e-139, Method: Composition-based stats. Identities = 132/668 (19%), Positives = 243/668 (36%), Gaps = 89/668 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ AR I + L K V GH+ + + Sbjct: 5 LIIVESPAKARTIKNFLGK-------------EYEVVASKGHIRDLPKTSFGIKIEED-- 49 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 Q + +K +A I A D DREG+ + + + Sbjct: 50 -------KFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKK 102 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 PE ++ R + +++ A+++A++ R+ + + AR D + G ++ Sbjct: 103 PE---ELPRIVFHEITKTAIKKALENPRTID--LNRVNAQQARRLLDRIVGYKLSPLLNK 157 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L LVV R+ EI+ F ++++ ++ + Sbjct: 158 KIQKG-----LSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYNGKK 212 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 + + + + A+ +V + V K + +P PF S LQ A+ Sbjct: 213 LD--------KFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVAS 264 Query: 303 KRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 G S + + I QKLYE +ITY R+D + +E + Sbjct: 265 SELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIK--QNIG 322 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQY 410 + + +AH AI P T L +E K+Y LI ++ Sbjct: 323 EEYAQAKT------YATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRF 376 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L DA F I + KG+F R L G+ + G + + T LP KG Sbjct: 377 LASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYG-----KPSANTLLPEFEKG 431 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 ++L E + + T+PP +T+A+L+ + + +G +T A Sbjct: 432 EKLKPEDVKATQHFTKPPERYTEASLIKKLESLG-----------------IGRPSTYAP 474 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCR 587 I LL R ++ K + +H T+ ++ +L + + TA+ E +L +++E + Sbjct: 475 TITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKD 534 Query: 588 YQDFMQPLVGTLYQLI----DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPP 643 +Q+ ++ +L+ + + + P G +K + A S P Sbjct: 535 WQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYP 594 Query: 644 ADEVGSGA 651 + Sbjct: 595 KCKYTRPL 602 >UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID=Q28MI5_JANSC Length = 907 Score = 499 bits (1285), Expect = e-139, Method: Composition-based stats. Identities = 140/722 (19%), Positives = 247/722 (34%), Gaps = 129/722 (17%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + + E P+ A+ I L + V GH+ + D Sbjct: 1 MPVVVVESPAKAKTINKYLG-------------SDYTVLASYGHVRDLPSKDGSVDPEEG 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL- 119 + + + + K + I L + + ++ A DPDREG+ + + + L Sbjct: 48 FFM----------KWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQEALT 97 Query: 120 -QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + A + V R N + AV +A+ R + L + LAR D+L G N++ Sbjct: 98 SRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVD--MELVEAYLARRALDYLVGFNLSP 155 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 G S GRVQ+ L LVV R+ EIE F ++++ V+A + TP + A Sbjct: 156 VLWRKL-----PGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + L A V +S + V+ K + + PF S LQ Sbjct: 211 RLTVLGGKKL---DRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA+++ G+ A+ + Q+LYE ITY R+D + E + + D Sbjct: 268 QEASRKLGMGAKQAMSTAQRLYEA-GHITYMRTDGIDMAPEAVEDARGAIKT--RYGVDY 324 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTE-NEAKVYNLIARQYLMQF 414 +P + + +AH + PT S A N L+E ++ K+Y+LI ++ + Sbjct: 325 VPGKPRIYKNKAK----NAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQ 380 Query: 415 CPDAVFRKCVIELDIAK--GKFVAKARFLAEAGWRTLLGSKERD--EENDGTPLPVVAKG 470 A + + + + A + + G+ + D ++ D LP V+ G Sbjct: 381 MEAARLERTTVTIASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAG 440 Query: 471 DELLCE-------------------------------------KGEVVERQTQPPRHFTD 493 D L + T PP +T+ Sbjct: 441 DPLKPSADAMADDYAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTE 500 Query: 494 ATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDA 553 ATL+ M + +G +T A I++ + RG++ K + D Sbjct: 501 ATLVKRMEELG-----------------IGRPSTYASIMDTIQNRGYVIKDKGRLIPEDK 543 Query: 554 GKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 G+ + L + D TA E L ++S Y+D + ID+ Sbjct: 544 GRLVTVFLSNYFNRYVQYDFTADLEQQLDEVSAGDRHYKDVLDRFWRDFRAAIDETSDLR 603 Query: 611 VRQFRGIV--------------------APGSGGSADKKKA--APRKRSAKKSPPADEVG 648 + + + P G + A + P Sbjct: 604 IGEVLDKINEVLEPHLFPDPGDGTDPRLCPNCGVGRLSMRTARAGGAFIGCSAYPECRYT 663 Query: 649 SG 650 Sbjct: 664 RP 665 >UniRef50_B0TFR0 DNA topoisomerase n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TFR0_HELMI Length = 781 Score = 499 bits (1284), Expect = e-139, Method: Composition-based stats. Identities = 186/698 (26%), Positives = 318/698 (45%), Gaps = 78/698 (11%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKPS A AIA+ + ++K G++E + +TW +GHL++ A+P+ Y S Sbjct: 1 MKTLIIAEKPSAAEAIAEAVAGTYQKKRGYLESPDFY-ITWAVGHLVQLAEPEDYRSSLK 59 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 RW DLPI+P+ +QL+P QL I ++ +++A D REG+L+ ++ YL Sbjct: 60 RWRFGDLPIIPD-FQLRPVKKTEGQLKTIAGLAKKSRALINACDAAREGELIFRYIVAYL 118 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 +L R L +A+ A+ L+ + L SA R+ DWL GIN TRA Sbjct: 119 RLE---EMPAWRLWTASLTAEAIRAAMADLKPLDRYDNLFKSARCRSEGDWLIGINATRA 175 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 +T +L++GRVQTPVL ++ + FV + ++EV A + + + Sbjct: 176 FTTRFGE-----LLTLGRVQTPVLAMICENRRRRDAFVPETYWEVWARFRGEGCD-YRGL 229 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 W + +E+G AE + + G+ V ++K E P + L+ LQ Sbjct: 230 WLREKGEAHRLNEKG------KAEAIAAAVDGRNGEVRQVDEKESRELPPRLYDLTTLQR 283 Query: 300 EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISV---HAP 356 E + FG SA L I Q+LY++ K ITYPR++ R++ + A V++ ++ + P Sbjct: 284 ECNRLFGFSANKTLKIAQELYDS-KFITYPRTNSRFVDKHGLALLRRVVSGLASHPVYGP 342 Query: 357 DLL-PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 + P + + + V+ HHA++PT L ++ KVY+ I R+ L + Sbjct: 343 FVAQGNPQLVHERNRNICRPEAVEDHHALLPTTLVP-TGLVGDKWKVYDRIVRRVLAHYY 401 Query: 416 PDAVFRKCVIELDI-----------------------------------AKGKFVAKARF 440 A +R+ V+ + F + + Sbjct: 402 LPARYRERVVLTVVPFERITGKATDLPVGDLGMATAVLDSAHSKEADDLGGAVFRSAEKT 461 Query: 441 LAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM 500 + + GW+ + G +E + P G + C EV+E+QT+PP+ +T+ +LL+AM Sbjct: 462 IIDPGWKVVDGGWTPPKEQE--RFPE-RAGLAVRCAGAEVLEKQTEPPKAYTEGSLLAAM 518 Query: 501 TGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS 560 + + D++L++I++ GLGT ATRA IE L + G++ +GR I T G AL Sbjct: 519 ETAGKQLDDEELREIMKDA-GLGTPATRAATIERLKEVGYIELQGRQIEPTPKGMALISL 577 Query: 561 LPE----MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR---- 612 + + + +MT WE L +I+ + +F + + L+ Q + Sbjct: 578 VEKSEIPLLLSAEMTGRWEKFLNEIARGNAQPLEFNRRVSDLAVYLVKQLEAAEKSWYDK 637 Query: 613 ---QFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 R P GG+ RK + ++ Sbjct: 638 SACARRLGTCPRCGGAIV----ENRKAYVCANWKVEQC 671 >UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms RepID=TOP1_SYNY3 Length = 898 Score = 499 bits (1284), Expect = e-139, Method: Composition-based stats. Identities = 139/669 (20%), Positives = 266/669 (39%), Gaps = 82/669 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQP-DAYDSRYAR 60 +L I E P+ AR I + LP+ V +GH+ + + + Y Sbjct: 3 KLVIVESPTKARTIRNYLPQ-------------DYRVEASMGHVRDLPASAEEVPAAYKD 49 Query: 61 WNLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 + A+L + E S K + ++ L A E++ A D DREG+ + +L Sbjct: 50 KSWANLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLLQ 109 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 LQ + ++R + +++ +A+ A++ R E L + R D L G ++ Sbjct: 110 LLQ----PKVPIKRMVFHEITQEAIRSALENCRDIDE--NLVHAQETRRILDRLVGYTLS 163 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +L + + LS GRVQ+ + L+V+R+ F ++++KA + F Sbjct: 164 ---PLLWKKIAWG--LSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELE-QNKNPFQ 217 Query: 238 AIWQPSEACEPYQ-------------DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 A + D++ +L A + R++G+P V + +K Sbjct: 218 AKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPG 277 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 PF+ S LQ EA ++ G+SA++ + + QKLYE ITY R+D +L ++ Sbjct: 278 VRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYE-EGYITYMRTDSVHLSDQAVTAA 336 Query: 345 HAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT----ARSSAINLTENEA 400 + + + + L +++ +AH AI P + L + E Sbjct: 337 RNCVQQM--YGKEYLSPQPKQYTTKSK----GAQEAHEAIRPAGTEFRIPNQTGLKDREL 390 Query: 401 KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE--- 457 +Y LI ++ + DA + + L + +F A + + G+ D Sbjct: 391 ALYELIWKRTVACQMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAA 450 Query: 458 -ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 EN LP + GD C + + V +TQPP +T+A+L+ + Sbjct: 451 LENQEVILPPLKVGDRPNCREIDTVGHETQPPARYTEASLVKTLE--------------- 495 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAH 573 ++G+G +T A II + RG++ + + + T A+ L T+ Sbjct: 496 --SEGVGRPSTYASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLESHFPDLVDTGFTSR 553 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAP 633 E L +I+ + ++ ++Q L + V+ + + P + + + A Sbjct: 554 MEQKLDEIAIGKTQWLPYLQGFF-----LGESGLENQVKVRQDQIDPAIAKAIELENLAA 608 Query: 634 RKRSAKKSP 642 + + K P Sbjct: 609 KVKIGKFGP 617 >UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y390_9BACT Length = 767 Score = 499 bits (1284), Expect = e-139, Method: Composition-based stats. Identities = 136/676 (20%), Positives = 243/676 (35%), Gaps = 90/676 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L + E P+ A+ + +L +G VV +GH+++ + + Sbjct: 74 LVVVESPTKAKTLTKILG-------------SGYVVKASVGHIVDLPKSRLAIDIENDFK 120 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 ++ A +I+ A DPDREG+ + V + L + Sbjct: 121 PE----------YILVKGKAPVKKELQAAAATAQKILLAADPDREGEAIAWHVAELLGVD 170 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 P++ R +++ AV A+ + + AR D L G ++ Sbjct: 171 PKENC---RVRFHEITADAVRNAVKEPAPID--MDRVDAQQARRVLDRLVGYTLSPLLWK 225 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 R LS GRVQ+ L ++ R++EIENFV +D++ V + + Sbjct: 226 KIRRG-----LSAGRVQSVALAILCEREQEIENFVPQDYWNVFVDATADDGRAYRLHVER 280 Query: 243 SEACEPYQD-EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 D + + + + +P IV S+ K+ + P PF S +Q A Sbjct: 281 ENGRSLLSDGKTLAIDTLAKVRDIEKTLKEKPLIVASFTAKKNARKQPAPFKTSTMQQIA 340 Query: 302 AKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 A R G S + + I Q L+E T L+TY R+D + E + V+ Sbjct: 341 ASRLGFSPRRTMGIAQSLFEGVAIPGHGTVGLVTYMRTDSLRMAPEALSQARKVIE--GR 398 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 LP V DAH AI PT + LT + ++Y++I R Sbjct: 399 WGKKYLPAKAVVYQA-----GANAQDAHEAIRPTDFALTPESIRESLTAEQYRLYDMIWR 453 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + AV ++ + K A+ + GW + +D + Sbjct: 454 RSVASQMAPAVVDSATLDCECGKYGLRAQGASVGFDGWGAVWDLDVKDA-----MIQKAR 508 Query: 469 KGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATR 528 +G+ L + + QT+PP FT++TL+ + DG+G +T Sbjct: 509 EGELLNIRNVQSEKEQTKPPARFTESTLIKTLED-----------------DGIGRPSTY 551 Query: 529 AGIIELLFKRGFLTK-KGRYIHSTDAGKALFHSLPEMA--------TRPDMTAHWESVLT 579 A I+E L+ R ++ + +GR + ++ G+++ L E T+ ES L Sbjct: 552 ATIVETLYDRSYVAREEGRKLKPSELGRSVNKFLLEHFDGKSTSPIVDVGFTSSMESSLD 611 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKRT-----PVRQFRGIVAPGSGGSADKKKAAPR 634 Q+ + + + + I +A++ P + G P G KK+ Sbjct: 612 QVESGKKNWVELIGQFWKPFTDAIAEAEKAPVVPPPPPELTGETCPQCGRPLVKKQGRFG 671 Query: 635 KRSAKKSPPADEVGSG 650 P Sbjct: 672 DFIGCSGFPECHYIKP 687 >UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=A8U7S1_9LACT Length = 701 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 173/656 (26%), Positives = 288/656 (43%), Gaps = 60/656 (9%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L IAEKPS+ + IA VL + G +VTW +GHLL P+ Y +A Sbjct: 11 MKTLIIAEKPSVGKEIARVLGATQKSKT--HIEGKDVIVTWALGHLLGLKMPEEYKKEWA 68 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLD 117 W+L LP++PEK P + QL IK+ V A D REG+L+ +L+ Sbjct: 69 TWDLNTLPLIPEKMLTTPLKNTRSQLKAIKQLADRKDIGSAVIATDAGREGELVARWILE 128 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y+ + ++R I+ +A++ ++L+ + ++ L SA+AR+ ADWL G+N+T Sbjct: 129 YVHF----NKPIKRLWISSQTDKAIKEGFNQLQPSKKYDTLYDSAVARSEADWLIGLNVT 184 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 RA T+ + LS GRVQTP L +V +++ +I++FV + F+ V+ I Sbjct: 185 RALTVKYQ-----DSLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLVIDGKKATIQD 239 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 + + R AE +V + + IV +K+ + APLP+ L+ L Sbjct: 240 SALRK-------------FSERQKAEDLVASLKNKSVIVKEIKEKQSIQQAPLPYDLTEL 286 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 Q EA R+ SA+ L + Q LYE HK+++YPR+D +YL ++ + AI APD Sbjct: 287 QREANLRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMIGTMKERVAAIQNFAPD 346 Query: 358 LLPQPVVDPD--IRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIARQYLMQF 414 + + + ++ KV HH IIPT + +E K+Y ++ +++ F Sbjct: 347 EVKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPEKMEADELKIYRMVVERFIGLF 406 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 P K I A F + + E GW+ E ++L Sbjct: 407 LPAYNVSKTTIVFSAATTLFSLQQEEVIEKGWKK---------EVQKQSEKGYQLNEQLT 457 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 + + T+ P ++ TLL M +GLGT ATRA IIE Sbjct: 458 QPTYTIQMQLTEAPARLSEGTLLQNMEK-----------------NGLGTPATRAEIIEK 500 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 L K + + + +T G+ L + P++T WE L +I++ + + F++ Sbjct: 501 LIKSDLMERNQNKLSTTPKGQQLLTLVNPALVTPELTRKWEEALEEIAKGTLKKEVFLKQ 560 Query: 595 LVGTLYQLIDQAKRT----PVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 + +L+ + K + + P G ++ K S Sbjct: 561 IKNETARLVTEIKNSTETYKDHALTTKICPDCGELLKERSGRDGKMLICSSTTCSY 616 >UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID=D0LEI6_GORB4 Length = 1031 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 136/634 (21%), Positives = 233/634 (36%), Gaps = 88/634 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-PDAYDSRYAR 60 RL I E P+ AR IA L + VV GH+ + + ++Y Sbjct: 17 RLVIVESPTKARKIAGYLG-------------SNYVVESSRGHIRDLPRGAADVPAKYKG 63 Query: 61 WNLADLPI-VPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A L + V E ++ P + +K + + E+ A D DREG+ + +L+ Sbjct: 64 QPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLE 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ + V+R + +++ A+ A + R + L + R D LYG ++ Sbjct: 124 TLK----PKIPVKRMVFHEITEPAIRAAAENPRDLD--IDLVDAQETRRILDRLYGYEVS 177 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA---DE 234 LS GRVQ+ ++V R+ E FV+ +++++ A++ + Sbjct: 178 PVLWKKVMPK-----LSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQ 232 Query: 235 RFTAIWQPSEACEPYQDEEGR------------LLHRPLAEHVVNRISGQPAIVTSYNDK 282 F A + + +L A + + + G V+S +K Sbjct: 233 TFNARLVGVDDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEK 292 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PF S LQ EA ++ S+ + I Q+LYE + ITY R+D L E Sbjct: 293 PYTRRPYAPFMTSTLQQEAGRKLRFSSDRTMRIAQRLYE-NGFITYMRTDSTTLSESAIN 351 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDK-KVDAHHAIIP------TARSSAINL 395 A A +L V P R K +AH AI P T A L Sbjct: 352 AARA-------QARELYGDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQL 404 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRTLL 450 +E ++Y LI ++ + DA + + F A R + G+ + Sbjct: 405 EADEFRLYELIWQRTVASQMADAKGTTLSLRMTGTASTGETCVFAASGRTITFPGFLSAY 464 Query: 451 GSKERD-----EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 D ++ LP + +G L + T PP FT+A+L+ + + Sbjct: 465 VETVDDLAGGQADDAENRLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELG- 523 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA 565 +G +T A II + RG++ KKG + + A+ L Sbjct: 524 ----------------IGRPSTYASIIGTIQDRGYVVKKGNALVPSWIAFAVVGLLEAYF 567 Query: 566 ---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L +I+ + ++ Sbjct: 568 QGLVDYDFTASLEDDLDEIASGRENRTRWLTEFY 601 >UniRef50_C8WNM4 DNA topoisomerase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WNM4_EGGLE Length = 741 Score = 496 bits (1277), Expect = e-138, Method: Composition-based stats. Identities = 189/674 (28%), Positives = 301/674 (44%), Gaps = 63/674 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L IAEKPS+AR IAD + H + DG+IE G G +++WC GH+++ P Y W+ Sbjct: 4 LIIAEKPSVARGIADAVGA-HERRDGYIEGG-GYLISWCRGHIIDLDFPQNYPQWSGHWS 61 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASE--IVHAGDPDREGQLLVDEVLDYLQ 120 ++ LP++PE+W+ +Q V+K L A +V+A D DREG+ + V + Sbjct: 62 MSQLPMIPERWRWSVTAP--EQYKVLKGLLDRADVELVVNACDADREGEGIFRRVWTHSG 119 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 ++ V+R L P+ V + + S++ L +A RA+ADWL G+N +RA Sbjct: 120 C----KKPVRRFWSTSLVPEQVRTDLAHAKPLSDYDGLADAAEGRAKADWLVGLNASRAL 175 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 + L LS GRVQTP L LVV R I F + FF+V+ + A R Sbjct: 176 SCLY----EGSRLSAGRVQTPTLALVVERTRAIRGFKSVPFFQVECSVGRTAHVRLAG-- 229 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 +L R A + G + ++E AP + L+ LQ + Sbjct: 230 -------------EKLKTRQEALRRAHAAVGSQCAILKVERRQEKCRAPKLYDLTGLQRD 276 Query: 301 AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI---SVHAPD 357 A+ R GL+A+ L+ Q LYE KL TYPR++ RY+ E V++AI + Sbjct: 277 ASTRAGLTAEETLNALQTLYE-KKLATYPRTESRYIGESDIPETARVLSAIAVPGIVGEA 335 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN---LTENEAKVYNLIARQYLMQF 414 R DD KV H AI+PTA A L E V LI + + Sbjct: 336 AAAGFDASRSDVARVADDSKVHGHGAILPTALLDAKEMAKLDGAERSVAILICCRLMAAT 395 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLG----------SKERDEENDGTPL 464 A K +E ++ + A + +A W + DE+++ + Sbjct: 396 MDPATKLKTKVEGEVNGDAYTASGSTVTDASWIAVDEACRAALAGGGKAAEDEDDEAQDI 455 Query: 465 P-VVAKGDELLCEK--GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL----R 517 P + +GD V + +T PP+ +TDATLLSAM R ++D++LK + Sbjct: 456 PADIEQGDSFTVADGDVRVKDGKTTPPKPYTDATLLSAMEHAGRSIEDRELKAAIEDDSM 515 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESV 577 + GLGT ATRA +IE L + ++ ++G+ + +T+ G+ L + + P++TA WE Sbjct: 516 HSGGLGTPATRARMIEKLIEAKYIRRRGKTLSATERGETLIDIVCDSLKTPELTAKWELA 575 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV--------APGSGGSADKK 629 L+ + + DF+ + G ++ +R V P G Sbjct: 576 LSHVERGEGSLSDFLSGIEGYTAAVVSDLERGFDPAQAAAVSGREELCRCPACGAPIVLS 635 Query: 630 KAAPRKRSAKKSPP 643 ++ ++ S Sbjct: 636 RS--GRQWQCSSSK 647 >UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms RepID=C1D174_DEIDV Length = 966 Score = 496 bits (1277), Expect = e-138, Method: Composition-based stats. Identities = 142/631 (22%), Positives = 233/631 (36%), Gaps = 87/631 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDSR 57 L I E P+ AR I L K G V IGH+ + + P+ Y Sbjct: 5 LVIVESPAKARTIEKYLGK-------------GYAVESSIGHIRDLPKSASDIPEKYKG- 50 Query: 58 YARWNLADLPIV-PEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W L I + P + + +++ +A EI+ A D DREG+ + + Sbjct: 51 -KAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIAWHLF 109 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 L+ + V+R + +++ +A++ AI R L + AR D LYG + Sbjct: 110 QELK----PKVPVKRMVFHEITKEAIQAAIAHPRQID--TNLVEAQEARRALDRLYGYEV 163 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 + LS GRVQ+ ++V R+ E FV+ ++++ T + F Sbjct: 164 SPVLWKKVAPK-----LSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTF 218 Query: 237 TAIWQPSEACEPYQDEEG-------------RLLHRPLAEHVVNRISGQPAIVTSYNDKR 283 A ++ RLL A+ + ++GQ VTS +K Sbjct: 219 PARLTDVGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKP 278 Query: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 ++ PF S LQ E +++ G +A + QKLYE ITY R+D L E Sbjct: 279 FTQRPYAPFITSTLQQEGSRKLGFAATRTMRAAQKLYE-GGYITYMRTDSTNLSVEAVTA 337 Query: 344 RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLTE 397 + + P + +AH AI P T S L Sbjct: 338 ARTQVTQM------YGPAFLHPQPRVYAKKAKNAQEAHEAIRPAGSSFRTPDSLRGELGG 391 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDI---AKGK--FVAKARFLAEAGWRTLLGS 452 +E ++Y+LI ++ + DA R + L A R + G+ Sbjct: 392 DEWRLYDLIWKRTVASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYVE 451 Query: 453 KERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 D E+ TPLP + +G ++ E +TQPP +T+A+L+ A+ Sbjct: 452 GSDDPNAALEDRDTPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAG---- 507 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--- 565 +G +T A I+ + RG+ TKKG+ + T A L Sbjct: 508 -------------IGRPSTYASILGTIQDRGYATKKGQALVPTWTAFATSALLEHHFGKL 554 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L I+ + +++ Sbjct: 555 VDYDFTARMEEDLDDIAGGRASRVPYLRRFY 585 >UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DDI1_9PROT Length = 725 Score = 495 bits (1275), Expect = e-138, Method: Composition-based stats. Identities = 139/669 (20%), Positives = 245/669 (36%), Gaps = 89/669 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E PS AR I + L K V GH+ + + Sbjct: 4 KLIIVESPSKARTIKNFLGK-------------EYEVIASKGHIRDLPKTSFGIKIEED- 49 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 Q + +K +A I A D DREG+ + + + Sbjct: 50 --------KFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAHVIGK 101 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 P + R + +++ A++ A+ R + + AR D + G ++ Sbjct: 102 DPSS---LPRIVFHEITKTAIKNALKNPRKLD--IDRVNAQQARRLLDRIVGYKLSPLLN 156 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 + LS GRVQ+ L LVV R+ EI+ F+ K+++ ++ + Sbjct: 157 KKIQKG-----LSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNLIKYNGK 211 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 E+ L R AE +VN + V+ K + +P PF S LQ A Sbjct: 212 KL--------EKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVA 263 Query: 302 AKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + G S + + I QKLYE +ITY R+D + +E + Sbjct: 264 SSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKEN--I 321 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP-----TARSSAINLTENEAKVYNLIARQ 409 + + +AH AI P T L+++E K+Y+LI + Sbjct: 322 GSEYAEAKTYT------TKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNR 375 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 +L DA F I L KG+F + L G+ + G + D T LP + Sbjct: 376 FLASQMKDAKFETQNIYLTNEKGEFKISGKKLIFDGFYKVYGKRGAD-----TLLPEFKE 430 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G++L E+ + + T+PP +T+A+L+ + + +G +T A Sbjct: 431 GEKLKPEEIKATQHFTKPPERYTEASLIKKLESLG-----------------IGRPSTYA 473 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 I LL R ++ K + +H T+ + +L + TA+ E +L +I+ Sbjct: 474 PTITLLQNRNYVEIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIARGNK 533 Query: 587 RYQDFMQPLVGTLYQLI----DQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSP 642 +Q+ ++ +LI ++ + + G + P G +K + A + Sbjct: 534 DWQEMLKEFYNPFMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNF 593 Query: 643 PADEVGSGA 651 P + Sbjct: 594 PKCKYTRPI 602 >UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q181Z2_CLOD6 Length = 742 Score = 494 bits (1273), Expect = e-138, Method: Composition-based stats. Identities = 176/627 (28%), Positives = 304/627 (48%), Gaps = 39/627 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY-- 58 M+L +AEKPS+A+ IA L R+ DG+ E GN ++T+ +GHL+ YD Sbjct: 1 MKLVLAEKPSVAKTIASFLGAKTRQ-DGYFE-GNDYIITYAVGHLVSLYDMKDYDKDKYS 58 Query: 59 ARWNLADLPIVPE-KWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEV 115 W + + P VPE K++ + S TKQ N +K+ L + +++A D DREG+L+ + Sbjct: 59 GSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLI 118 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 + ++ V+R L+N+ P+ + R I L+ E L + R DWL GIN Sbjct: 119 FLLAK----NKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGIN 174 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER 235 T T+ G +L++GRV P + LV RD EI NFV K ++E++ H A E Sbjct: 175 FTSVATL---KYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEY 231 Query: 236 FTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLS 295 + + +E + A ++ I+ + + E AP FSL+ Sbjct: 232 ---------KGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLT 282 Query: 296 ALQ-IEAAKRFGLSAQNVLDICQKLYE---THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 +LQ +K ++ VL++CQ LYE ITYPR+D +L E + ++ + Sbjct: 283 SLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKL 342 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 V L + + R +D KVD+H AIIPT L+++E VY+ I +++ Sbjct: 343 KV---GLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKS-LSKDEQLVYDAIKDRFV 398 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F P A + I+ ++ F+ K + L G+ + +E+++ LP+V K D Sbjct: 399 ANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKND-----LLPLVNKDD 453 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 + + + + +QT PP+ +T+ TLL AM + V ++D + + +GT ATRA + Sbjct: 454 VVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDT--TVLSGYSIGTSATRADV 511 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQD 590 ++ + + G++ KKG+ T+ GK L P + D T E L+ I + + ++ Sbjct: 512 LKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKE 571 Query: 591 FMQPLVGTLYQLIDQAKRTPVRQFRGI 617 ++ ++ +YQ ++ K+ + Sbjct: 572 YLTNIISFIYQNVNIIKQDASKNINTE 598 >UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1_SYNE7 Length = 883 Score = 494 bits (1272), Expect = e-138, Method: Composition-based stats. Identities = 135/665 (20%), Positives = 257/665 (38%), Gaps = 80/665 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQP-DAYDSRYAR 60 +L I E P+ AR I + LPK V +GH+ + Q + Sbjct: 3 KLVIVESPTKARTIRNYLPK-------------DYRVEASMGHVRDLPQSASDIPTELKG 49 Query: 61 WNLADLPIVPEK---WQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 ++L + E K + +K L +A E++ A D DREG+ + +L Sbjct: 50 EKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQ 109 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 LQ R +R + +++ +A++ A+ R + L + R D L G ++ Sbjct: 110 LLQ----PRVPTKRMVFHEITQEAIQAALKNCRDVDQ--RLVHAQETRRILDRLVGYTLS 163 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 +L + + LS GRVQ+ + L+V+R+ F ++++KA + A + Sbjct: 164 ---PLLWKKIAWG--LSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEA 218 Query: 238 AIW----QPSEACEPYQDEEGRL--------LHRPLAEHVVNRISGQPAIVTSYNDKRES 285 +W Q + + G++ L + AE + +R+ QP V S +K + Sbjct: 219 KLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTT 278 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 PF+ S LQ E+ ++ LSA+ + + Q LYE ITY R+D +L ++ Sbjct: 279 RKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYE-RGFITYMRTDSVHLSQQAIEAAR 337 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINLTENEAK 401 + + + + + L +++ +AH AI P L+ E Sbjct: 338 SCVEQM--YGKNYLSPQPRQFTTKSK----NAQEAHEAIRPAGNTFRLPQETGLSGAEFA 391 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE---- 457 +Y+LI ++ + +A + L++ +F A + + G+ D Sbjct: 392 LYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAAL 451 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 E+ LP + GD C++ + +TQPP +T+A+L+ + Sbjct: 452 EDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLEN--------------- 496 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHW 574 +G+G +T A II + RG+ + T A+ L + +A Sbjct: 497 --EGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARM 554 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPR 634 E L IS + + ++ D+ V+ + P + + + + Sbjct: 555 EQSLDDISNGEVDWLPYLSQFYRG-----DRGLEEQVKLRESEIDPAAARTVALEGLPAK 609 Query: 635 KRSAK 639 R + Sbjct: 610 VRIGR 614 >UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 RepID=D0D7V2_9RHOB Length = 918 Score = 494 bits (1271), Expect = e-138, Method: Composition-based stats. Identities = 131/722 (18%), Positives = 249/722 (34%), Gaps = 128/722 (17%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + + E P+ A+ I L + V GH+ + D Sbjct: 1 MPVVVVESPAKAKTINKYLG-------------SDYTVLASYGHVRDLPAKDGSVDTDHD 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + K + I L + ++ A DPDREG+ + + + L Sbjct: 48 FEM----------TWEIANDSRKHVAAIAEALKNDNSLILATDPDREGEAISWHLREALT 97 Query: 121 LAPEKRQQ--VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 ++ V R N + AV A+ R PL + LAR D+L G N++ Sbjct: 98 KRRSIKKDTAVSRVTFNAITKSAVTEAMQNPREID--APLVEAYLARRALDYLVGFNLSP 155 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 G S GRVQ+ L L+V R+ EIE F ++++++KA + TP + + A Sbjct: 156 VLWRKL-----PGARSAGRVQSVCLRLIVEREMEIEAFRPREYWQIKALLSTPRGQEYEA 210 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + + + + AE V ++ + + S + + + PF S LQ Sbjct: 211 RLTVLGGKKL---DRFDIGNATQAELAVQAVASRKLKIDSVEARPSTRNPSAPFMTSTLQ 267 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 EA+++FG+ A+ ++ Q+LYE ITY R+D + E + + + Sbjct: 268 QEASRKFGMGARACMNAAQRLYEA-GHITYMRTDGIDMAPEAITACRDAI--ADRYGKEY 324 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN----LTENEAKVYNLIARQYLMQF 414 +P + + +AH I PT + +++ K+Y+LI ++ L Sbjct: 325 VPGSPRIYKNKAK----NAQEAHECIRPTDMTRDAASLKLREDDQRKLYDLIWKRTLACQ 380 Query: 415 CPDAVFRKCVIELDIAKGK--FVAKARFLAEAGWRTLLGSKERD-EENDGTPLPVVAKGD 471 A + +E+ + A + + G+ + D ++D LP + +G+ Sbjct: 381 MEAARLERTTVEILSEDRQVGLRATGQVVLFDGFLKVYEEGRDDVSDDDENRLPQIMEGE 440 Query: 472 ELLCEKGEV--------------------------------------VERQTQPPRHFTD 493 K + + TQPP +T+ Sbjct: 441 PAAFAKATLQAQYDKASDKAEDVVEDAPAGMQKSSAAVLSDNGAVLATQSHTQPPPRYTE 500 Query: 494 ATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDA 553 ATL+ M + +G +T A +I + R ++ K+ + D Sbjct: 501 ATLVKRMEELG-----------------IGRPSTYASVITTIQDREYVRKEQNRLFPEDK 543 Query: 554 GKALFHSLPEMATR---PDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 G+ + L + + TA E+ L ++S + Y+ + I + Sbjct: 544 GRIVTIFLLNFFRKYVGYEFTAELENELDEVSAGEMDYKSLLAKFWRDFSAAIGETSELR 603 Query: 611 VRQFRGI--------------------VAPGSG-GSADKKKAAPRKRSAKKSPPADEVGS 649 + + + + P G G K + + P Sbjct: 604 ISEVLDVLDEALAPQLYPPREDGSDPRICPKCGQGRLHLKTSRTGGFVGCGNYPECTYTR 663 Query: 650 GA 651 Sbjct: 664 PI 665 >UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=Q47L55_THEFY Length = 906 Score = 493 bits (1270), Expect = e-138, Method: Composition-based stats. Identities = 140/633 (22%), Positives = 237/633 (37%), Gaps = 86/633 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPD-AYDSRYAR 60 +L I E P+ A+ IA L G +V IGH+ + +RY Sbjct: 22 KLVIVESPAKAKTIAGYLG-------------PGYIVESSIGHIRDLPNKAAEIPARYKD 68 Query: 61 WNLADLPIV---PEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A L + + Q+ +K L EA E+ A D DREG+ + + + Sbjct: 69 EPWARLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAIAWHLRE 128 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ V+R + N++ +A+ A R + + L + R D LYG ++ Sbjct: 129 ELK----PTIPVKRMVFNEITKEAIRHAAQHTRDLN--LRLVDAQETRRILDRLYGYEVS 182 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV------TP 231 + LS GRVQ+ LVV R+ E F +++ +KA Sbjct: 183 PVLWKKVMPS-----LSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGA 237 Query: 232 ADERFTAIWQPSEACEPYQDEEG------------RLLHRPLAEHVVNRISGQPAIVTSY 279 F A + Q + R L A + R++G V S Sbjct: 238 DPTTFPATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSV 297 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K S PF + LQ EA+++ GLSA+ + + Q+LYE + ITY R+D L E Sbjct: 298 ERKPYRRSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYE-NGYITYMRTDSTTLSES 356 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINL 395 A A + + + + LP + + +AH AI P + L Sbjct: 357 AIAAARAQVARL--YGDNYLPDKPRTYTSKVK----NAQEAHEAIRPAGDTFRTPAETGL 410 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRTLL 450 + E ++Y LI ++ + DAV + + + +F A + + G+ Sbjct: 411 SGVELRLYELIWKRTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAY 470 Query: 451 GSKERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 D ++ LP + +GD L + + T+PP +T+A+L+ + Sbjct: 471 VEGTDDPQAELDDRERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELEE---- 526 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA- 565 +G +T A II + +RG++ KKG + + A+ L Sbjct: 527 -------------REIGRPSTYATIIGTILERGYVFKKGSALVPSFLAFAVVQLLERHFS 573 Query: 566 --TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E VL I+ + +++ Sbjct: 574 HLVDYDFTARMEDVLDAIARGEAERVPWLRRFY 606 >UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota RepID=TOP3A_DROME Length = 1250 Score = 493 bits (1269), Expect = e-137, Method: Composition-based stats. Identities = 142/708 (20%), Positives = 250/708 (35%), Gaps = 107/708 (15%) Query: 1 MR-LFIAEKPSLARAIADVLPKPH-RKGDGFIECGN-------------GQVVTWCIGHL 45 M+ L +AEK A+ IA +L ++ +G+ V+T GH+ Sbjct: 26 MKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHM 85 Query: 46 LEQAQPDAYDSRYARWNLADLPIVPEKWQLQ-PRPSVTKQLNVIKRFLHEASEIVHAGDP 104 ++ A + Y W D + + + ++R + ++ D Sbjct: 86 MQLA----FQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDC 141 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREG+ + E++D + A + V R +++ AV RA+ +L + + Sbjct: 142 DREGENIGYEIIDVCR-AIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQS--DAVDV 198 Query: 165 RARADWLYGINMTRAYTILGRNAGY----QGVLSVGRVQTPVLGLVVRRDEEIENFVAKD 220 R D G +TR T+ + ++S G Q P LG V R +EIE FV++ Sbjct: 199 RTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEP 258 Query: 221 FFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP---AIVT 277 F+++K + + + RL + E+ + +P A+V Sbjct: 259 FWKIKV------------LHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVE 306 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 S K + + P P ++ +++ LSA+ + I +KLY T I+YPR++ Sbjct: 307 SVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLY-TKGFISYPRTETNQFS 365 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE 397 +E FA V Q V++ R +K AH I PT + NL Sbjct: 366 KE-FALAPLVEMQTGHRDWGAFAQRVIEWGPNPR-NGNKSDQAHPPIHPTKLA--ENLQG 421 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDE 457 NEA+VY L+ R +L DAV + ++ +DIA KF A + E + + + Sbjct: 422 NEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVY----D 477 Query: 458 ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 + + G + + E T P T+A L++ M Sbjct: 478 KWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEK--------------- 522 Query: 518 ATDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAH 573 G+GT+AT A I + +RG++ ++ G L+ M +P + A Sbjct: 523 --HGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAE 580 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR--------------------- 612 +E L I + Q + + + Q Q Sbjct: 581 FELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQE 640 Query: 613 -----------QFRGIVAPGSGG---SADKKKAAPRKRSAKKSPPADE 646 P + KK + P + Sbjct: 641 GADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCK 688 >UniRef50_C3CTB0 DNA topoisomerase n=1 Tax=Bacillus thuringiensis Bt407 RepID=C3CTB0_BACTU Length = 787 Score = 492 bits (1266), Expect = e-137, Method: Composition-based stats. Identities = 193/669 (28%), Positives = 310/669 (46%), Gaps = 69/669 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVV--TWCIGHLLEQAQPDAYDSRYAR 60 L IAEKPSL R I + G+ + GH + PD Y +A+ Sbjct: 8 LLIAEKPSLMREIQSA----------YHTFGHKDTIEFKSFAGHTMGLINPDKYKEEWAK 57 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQLLVDEVLDY 118 W+LA LP+VP+K+ +P IK+ + I++ DP REGQ + D Sbjct: 58 WDLATLPLVPDKFLYEPTKDKLDMYKDIKKAIKNGNYDYIINGCDPGREGQHIFFSFYDS 117 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSE--FVPLCVSALARARADWLYGINM 176 + V+R +DL + ++RA+D LR +E + ++ RA DWL G+N Sbjct: 118 IGC----NLPVKRIWHSDLTEKELKRALDNLRDENEPALSNMTKASKLRAYFDWLIGMNF 173 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 TRA++I+G +++GRV TP L ++V R+ EI+NFV K+F+E++A F Sbjct: 174 TRAFSIVGGKK-----MNLGRVMTPALKVLVDRELEIKNFVPKNFWEIEADFGKYKGVHF 228 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 +D + + + A+ +++ +S V N +++ + AP SLSA Sbjct: 229 N------------EDGDTQFWKQEDAQKIIDSLSTDS-TVKIVNQEKDVKYAPQLHSLSA 275 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQ EA +G + Q L+I Q LYE K ++YPR+D +L + + A+M + P Sbjct: 276 LQNEANSVYGYTMQETLNITQTLYE-KKFVSYPRTDSSHLTK-AISNDFAIMLRPLQNIP 333 Query: 357 DLL---------PQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKVYNLI 406 +L + + D + DDKKV H+AI+PT S LT+ E VY LI Sbjct: 334 ELADKTKAIINDSKILSDIANNKKYVDDKKVSDHYAIVPTGLSPDFGRLTDKEINVYMLI 393 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 A+++L F P V +K + + F L G+ L K +D LP Sbjct: 394 AKRFLSIFLPPMVSQKTSVVTENNGHLFKTSGSVLESIGFMALYNYKAQD-----NMLPP 448 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + KG+ + +K E++ +QT P +TD TL AM RF+ D +LK++L+ G+GT A Sbjct: 449 LKKGEMVSLKKAELITKQTSKPGRYTDRTLNIAMENAGRFIDDDELKEVLKEAKGIGTPA 508 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQ 585 TR GI+E L + +K + +T+ G + SL T P++TA WE L++I Q Sbjct: 509 TRGGIVEKLVSLNMIERKKKSFFATEYGIGIIQSLNGHDITSPELTAKWEQKLSEIEANQ 568 Query: 586 CRYQDFMQPLVGTLYQLIDQAKRTPV----RQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 F + ++ + + ++ K+ V + P G KK Sbjct: 569 FDPNVFYKEMIAYIQKEVEDLKKLKVFVSSSKDSLGSCPKCGKHVI---------EGKKY 619 Query: 642 PPADEVGSG 650 + +G Sbjct: 620 YLCEAYKNG 628 >UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7J0A2_ORYSJ Length = 928 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 141/686 (20%), Positives = 252/686 (36%), Gaps = 83/686 (12%) Query: 3 LFIAEKPSLARAIADVLPKPH---RKGDGFIECGNGQ-------------VVTWCIGHLL 46 L +AEKPS+A+++A++L +P R +G +VT GHL+ Sbjct: 13 LNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTGHLM 72 Query: 47 EQAQPDAYDSRYARWNLADLPIVPE-KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPD 105 E +D R+ RW+ D + + ++ + +V D D Sbjct: 73 EL----EFDDRFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWLDCD 128 Query: 106 REGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALAR 165 REG+ + EV+D R + R + L + + A+ L ++ + AR Sbjct: 129 REGENIAYEVIDIC-AGANSRLNIWRARFSALIDREIHEAVQHLDRPNKLF--ADAVDAR 185 Query: 166 ARADWLYGINMTRAYTILGRNAG--------YQGVLSVGRVQTPVLGLVVRRDEEIENFV 217 D G + TR T+L ++A +LS G Q P LG +V R EI+ Sbjct: 186 QEIDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHE 245 Query: 218 AKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIV 276 ++F+ + E + G L A + +P A V Sbjct: 246 PEEFWTINCS------------HTSDEGTASFGWIRGHLFDYSSAVVIYEMCVEEPMATV 293 Query: 277 TSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL 336 + ++ + + P P S LQ A++ F +S+++ + + ++LY+ I+YPR++ Sbjct: 294 QNVRNQEKLKYPPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQA-GFISYPRTETDNF 352 Query: 337 PEEHFAGRHAVMNAISVHAPDLLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSS-AI 393 + + + RN AH I PT S+ Sbjct: 353 SPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAGET 412 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSK 453 N T+N K+Y L+ R +L AV + +E+DIA +F A R + + + Sbjct: 413 NWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVYRF- 471 Query: 454 ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 + GT LP G + + + T+PP +A LL M Sbjct: 472 ---DSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAG--------- 519 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM---ATRPD 569 +GT+AT I+ L R + TK T+ G+AL EM +P Sbjct: 520 --------IGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYDEMGYELWKPY 571 Query: 570 MTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKK 629 + + E+ + +S + ++ + + A+ V+ F + G+ + Sbjct: 572 LRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAM------GTFFAR 625 Query: 630 KAAP---RKRSAKKSPPADEVGSGAI 652 + P + S + P + Sbjct: 626 SSRPVNETQNSIETVRPCAACNESEM 651 >UniRef50_A2UW18 DNA topoisomerase, type IA, central n=1 Tax=Shewanella putrefaciens 200 RepID=A2UW18_SHEPU Length = 708 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 207/682 (30%), Positives = 318/682 (46%), Gaps = 37/682 (5%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG-----QVVTWCIGHLLEQAQPDAYD 55 M L IAEKP++A+AIA L K R +G+I+CG Q+V+WCIGHLL P+ ++ Sbjct: 1 MHLIIAEKPAVAKAIAGYLNKNARSCNGYIDCGADGKGQKQIVSWCIGHLLTFKTPEEHN 60 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 Y W + LP+ L+P QL + L A+ + HAGD D EGQ+LVDEV Sbjct: 61 PLYKTWAVETLPMQLLPLTLKPIAKTKAQLKTLLDLLKSANLVTHAGDDDDEGQILVDEV 120 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 LDY + + QV R INDLN ++ +A ++ NS+F+ SA R+ D++YG+N Sbjct: 121 LDYAK----YKGQVNRLKINDLNEASIAKAFSNVKPNSQFLSQSQSAYGRSAFDFIYGLN 176 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV-TPADE 234 +TR T+L +G GV SVGRVQ+ +L LVV R + + ++++ A + Sbjct: 177 LTRLCTVL---SGNGGVFSVGRVQSAILSLVVERCRLNRSHTSIPYYDIFAAVRFREGAI 233 Query: 235 RFTAIWQPSEACEPYQ-DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFS 293 +F CEP + D++ RLL RP AE + + G+ +T + S PLPFS Sbjct: 234 KFKVDLNEIAECEPEKFDDKKRLLDRPQAEFIKLSLEGRSVNITDLDRTNSEASPPLPFS 293 Query: 294 LSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV---MNA 350 L LQ + F S + L + Q L E HKLITY R+D YLPEE + + Sbjct: 294 LLDLQKACSNLFDYSPEQTLKLTQSLREDHKLITYNRTDTGYLPEEFHPQGAHIANCIKL 353 Query: 351 ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQ 409 + R AHH IIP + +T++E VY LI R Sbjct: 354 NCSAFAAAVDAADFSIKSRAFSDAKVAESAHHGIIPCDVRADMGKVTKDEMNVYMLICRN 413 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL-PVVA 468 +L QF P + + + K A + GW L + +++ + L + Sbjct: 414 FLAQFFPKKITAHIKVTASAGEYKLTAMGSQIERNGWSALYSGESFEDDEEQAELTQELT 473 Query: 469 KGDELL-----------CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL- 516 DEL + E +++P + + LL + A +V +++LK++L Sbjct: 474 AFDELDGLGKYDSGHIYSGDTSLREGKSKPKALYVMSRLLEDLKKAATYVTNENLKRVLI 533 Query: 517 ------RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDM 570 + G+GT ATR IIELLF R F+ KG+ I +T G+ + LP D+ Sbjct: 534 ERDKGTQEKGGIGTPATRGSIIELLFNRQFIEMKGKKIIATPFGEQAYDQLPSYLASVDL 593 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKK 630 TA W+ + Q+ +++ F+ + G + Q ++ K + + + G A K Sbjct: 594 TAFWQLKMNQVRDRELSIGRFLTEVDGFVTQAVNHIKSQGISITSQPTSKTNKGKAGAKS 653 Query: 631 AAPRKRSAKKSPPADEVGSGAI 652 P+ S + G I Sbjct: 654 GKPKMASTATEFQCKQCGEKLI 675 >UniRef50_D2J7B8 DNA topoisomerase n=2 Tax=Staphylococcus aureus RepID=D2J7B8_STAAU Length = 705 Score = 491 bits (1263), Expect = e-137, Method: Composition-based stats. Identities = 166/662 (25%), Positives = 299/662 (45%), Gaps = 43/662 (6%) Query: 1 MRLFI-AEKPSLARAIADVLPKPHRKGDGFIECGN-----GQVVTWCIGHLLEQAQPDAY 54 M+ I AEKPS AR A+ L H+K DG+IE N G ++TW GHL+E P Y Sbjct: 1 MKTVIFAEKPSQARDYANALGISHKK-DGYIEGVNPLFDGGVIITWGFGHLVELKLPKDY 59 Query: 55 DSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 + W+L +LP P ++ + +KQ N++K +A +++A D DREG + Sbjct: 60 SNPINNWDLKNLPYRPSPFEYKVSEGKSKQFNIVKTLFKDADILINATDIDREGSNIFYS 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 L + K + ++R IN L + +++ +L++N + A AR +D+L G+ Sbjct: 120 TLKLTGV---KNKTIKRLWINSLVEKEIKKGFQQLQNNHQDYQNYQEAYARQTSDYLIGM 176 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N++ Y+ + + G Q V S+GRVQTP L ++ R IENF + F+E+ + Sbjct: 177 NLSPVYSKIFQLQGVQDVFSIGRVQTPTLYMIYERYLAIENFKPETFYEIFGEFESKNGC 236 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + ++ +++ ++ + + I+T + + S+P SL Sbjct: 237 Y-------KGKAKIKTTDKQEIINLGEKHNLKDA---KEGIITKLETQEKRTSSPKLHSL 286 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 S LQ + K++ S + +I Q LYE K+++YPR+DC Y+ E + + ++ Sbjct: 287 STLQSKINKQYKYSPEKTKNIVQSLYE-KKILSYPRTDCNYITSEEYLYLKENLQSLMNV 345 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQY 410 +V R R +++KV H+AIIPT++ L+++E V + + Sbjct: 346 YNKHF--SIVYDKPRARYVNNEKVKEHYAIIPTSQIPTPQNIEKLSQDEKYVLDEVVSTT 403 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 L F D V+ + IE ++ + F + GW+ L K +E++ LP + K Sbjct: 404 LSMFANDYVYDETKIETNVNQLIFYTTGHTEIQKGWKILFKHKG-NEKSPEQQLPKLIKN 462 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 + + + TQ P+ +T+ L++ M +++ D++ +IL+ G+GTEATR G Sbjct: 463 ECVKA-NIYSNKGITQSPKLYTEGQLITLMKSCGKYLDDEE-AEILKEIQGIGTEATRDG 520 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQ 589 II+ L + ++ + +H T G L ++ + MTA WE L I + Q Sbjct: 521 IIQSLKNKNYIKIEKNKVHITAKGILLCKAVKGSLLASATMTAAWEKRLKLIGQGQANTD 580 Query: 590 DFMQPLVGTLYQLIDQAKRT------------PVRQFRGIVAPGSGGSADKKKAAPRKRS 637 +F+ + + + I + + P K + Sbjct: 581 NFIDITMKFIDKEIKAYQEKCEDKSIINQSNIVAKDNEFGECPNCTDGQLIDKNKIISCT 640 Query: 638 AK 639 Sbjct: 641 NC 642 >UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota RepID=TOP3B_HUMAN Length = 862 Score = 491 bits (1263), Expect = e-137, Method: Composition-based stats. Identities = 130/686 (18%), Positives = 250/686 (36%), Gaps = 85/686 (12%) Query: 1 MR--LFIAEKPSLARAIADVLPKPH---RKGDGFIECGNGQV-----------VTWCIGH 44 M+ L +AEKPSLA++IA +L + KG + +T GH Sbjct: 1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH 60 Query: 45 LLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTK--QLNVIKRFLHEASEIVHAG 102 ++ + +Y +W+ D + + + + + K + ++ IV Sbjct: 61 VMTL----DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWL 116 Query: 103 DPDREGQLLVDEVLD----YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPL 158 D D+EG+ + EVLD + A + V R + + + A+ L L Sbjct: 117 DCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEAL 176 Query: 159 CVSALARARADWLYGINMTRAYTILGRNAGYQ---GVLSVGRVQTPVLGLVVRRDEEIEN 215 S AR D G TR T + ++S G QTP LG V R ++I++ Sbjct: 177 --SVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQS 234 Query: 216 FVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPA 274 F + ++ ++A + T + + R+ R +A+ +N + A Sbjct: 235 FKPETYWVLQAKVNTDK-----------DRSLLLDWDRVRVFDREIAQMFLNMTKLEKEA 283 Query: 275 IVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCR 334 V + + K +++ PL + + A+ G+ Q+ + ++LY T I+YPR++ Sbjct: 284 QVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY-TQGYISYPRTETT 342 Query: 335 YLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN 394 + PE A + D + + + + R R H I P ++ Sbjct: 343 HYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPR--KGHDAGDHPPITPMKSATEAE 400 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE 454 L + ++Y I R ++ D + + I I F + + G+ ++ + Sbjct: 401 LGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQS 460 Query: 455 RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 E LP +GD + +++E+QT PP + T+A L++ M Sbjct: 461 VPLEES---LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEK------------ 505 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFLTKK-GRYIHSTDAGKALFHSL---PEMATRPDM 570 G+GT+A+ I + +R ++T + GR + T+ G L H P + Sbjct: 506 -----HGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTI 560 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI----------DQAKRTPVRQFRGI--- 617 + E L I++ + Y+ + + + D+ Sbjct: 561 RSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKP 620 Query: 618 --VAPGSGGSADKKKAAPRKRSAKKS 641 +A P + Sbjct: 621 LSRCGKCHRFMKYIQAKPSRLHCSHC 646 >UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax=Chlamydiales RepID=Q256J1_CHLFF Length = 862 Score = 489 bits (1259), Expect = e-136, Method: Composition-based stats. Identities = 139/683 (20%), Positives = 245/683 (35%), Gaps = 89/683 (13%) Query: 1 MR--LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRY 58 M+ L + E P+ + + +L K G + +GH+++ Sbjct: 1 MKKSLIVVESPAKIKTLQKLLGK-------------GFIFASSLGHVVDLPAKTFGIDIE 47 Query: 59 ARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + Q P + +N I + + + DPDREG+ + + + Sbjct: 48 HDFEPD----------YQILPDKQEVINQICKLASSCDVVYLSPDPDREGEAIAWHIANQ 97 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L K Q+QR N + AV A+ R + L + AR D + G ++ Sbjct: 98 L----PKNTQIQRVSFNAITKGAVNEALKHPREID--MALVNAQQARRLLDRIVGYKISP 151 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER-FT 237 + R + +S GRVQ+ L LVV R++ IE FV +++ ++ + P + F Sbjct: 152 ILS---RKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFW 208 Query: 238 A--------IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 A W+ +DE + A+H + VT K + +A Sbjct: 209 AHLYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAA 268 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHF 341 PF S LQ EA++ F S+ + + Q LYE LITY R+D + E Sbjct: 269 PPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEAL 328 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LT 396 + D Q + DAH AI PT + + LT Sbjct: 329 NNVRDYIQ-------DTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLT 381 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIA-KGKFVAKARFLAEAGWRTLLGSKER 455 ++ +Y+LI ++++ A++ + + K A L G+ + K Sbjct: 382 NDQHMLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKID 441 Query: 456 DE--ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 D+ E + LP + D L EK + T+P FT+A+L+ + Sbjct: 442 DDVAEEENPSLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEK----------- 490 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDM 570 G+G +T A I+ + R + K+ + + T+ GK + L Sbjct: 491 ------SGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGF 544 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPV--RQFRGIVAPGSGGSADK 628 TA E L I++ + ++ ++ ++ A++ V R I Sbjct: 545 TALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVVTDIDCSACHKGKLV 604 Query: 629 K-KAAPRKRSAKKSPPADEVGSG 650 K A R P + + Sbjct: 605 KIWAKNRYFYGCSEYPECDFKTS 627 >UniRef50_A6TMD4 DNA topoisomerase n=20 Tax=Clostridiales RepID=A6TMD4_ALKMQ Length = 775 Score = 489 bits (1259), Expect = e-136, Method: Composition-based stats. Identities = 178/691 (25%), Positives = 328/691 (47%), Gaps = 52/691 (7%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+IAEKPS+A A L K DGFIE VVTWCIGHL+ + PD YD +Y +W Sbjct: 5 LYIAEKPSVALEFAKTLNIKGNKKDGFIESNE-AVVTWCIGHLVTMSYPDKYDDKYKKWV 63 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEAS--EIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +P K++ + +V KQ ++IK + I D REG+ + V + + Sbjct: 64 LKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVN 123 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + + +R I+ + +++ + + E+ L +A RA+ D+L GIN +R Sbjct: 124 VKGKTK---KRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLL 180 Query: 181 TILGRNAGYQG------VLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 T+ +A + V++VGRV T VLG+VV+R+ EI FV ++++ ++ Sbjct: 181 TLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSM 240 Query: 235 RFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQ----PAIVTSYNDKRESE 286 + W+ E+ Y ++ AE + + A+V + K+E++ Sbjct: 241 DYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETK 300 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 + PL ++L+ LQ E +K+ ++ L + QKLYE K+ITYPR+D R L H+ Sbjct: 301 NPPLLYNLAELQNELSKKLKINPDETLKVAQKLYE-KKMITYPRTDARVLSNAVAKEIHS 359 Query: 347 VMN----------------AISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR- 389 + I+ ++ + + + + +DK + H+AIIPT Sbjct: 360 NLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEG 419 Query: 390 -SSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRT 448 S LT+ E + + LI R++L F P A+F + I I F ++ + G+ Sbjct: 420 LGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLE 479 Query: 449 LLGSKERD---EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 +L ++D + L + KG + K E+ E +T PP+ ++ +++ AM + Sbjct: 480 ILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGK 539 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRY--IHSTDAGKALFHSLPE 563 ++D++L++ ++ + G+GT ATR+GI+ L + ++ + + T G++++ + E Sbjct: 540 LIEDEELREKIKGS-GIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDE 598 Query: 564 ---MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR----QFRG 616 +P++TA WE L I+ + + ++M L + + + + + R Sbjct: 599 SIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRS 658 Query: 617 IVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 I + + G+ D K + + K + Sbjct: 659 IKSTTNKGNQDTKGKRVGRLALGKCIACETG 689 >UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID=C7MGF4_BRAFD Length = 904 Score = 488 bits (1257), Expect = e-136, Method: Composition-based stats. Identities = 133/634 (20%), Positives = 237/634 (37%), Gaps = 85/634 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ AR I L V +GH+ + P + + Sbjct: 6 HLVIVESPAKARTIGRYLG-------------EEYDVKASVGHIRDIPVPRDLPAEMKKG 52 Query: 62 NLADLPIVPEKWQ---LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 + E P K + +K+ L +A + A D DREG+ + +L+ Sbjct: 53 PYGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAWHLLET 112 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ P+K V+R + +++ A+ A++ R L + R D L G ++ Sbjct: 113 LK--PKKSLPVKRMVFHEITKDAIRAALENTRDID--ASLVDAQETRRILDRLVGFELSP 168 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE---R 235 + + LS GRVQ+ LVV R+ E FVA D++++ + Sbjct: 169 VLWRKIKPS-----LSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQ 223 Query: 236 FTAIWQPSEACE-------------PYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDK 282 FTA + + + +L + +V + PA VT+ K Sbjct: 224 FTAKIATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESK 283 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 + PF+ S+LQ EA+++ L A+ + + Q LYE + ITY R+D L E Sbjct: 284 PYTRRPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYE-NGYITYMRTDSVTLSGEAIR 342 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLT 396 A A ++ +P +++ +AH AI P T A L+ Sbjct: 343 ASRA--QAAELYGSQFVPDKPRYYQNKSQA----AQEAHEAIRPAGDHFRTPAEVAGQLS 396 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLG- 451 +E ++Y LI ++ + DA +EL + F A + G+ Sbjct: 397 GDEFRLYELIWKRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEE 456 Query: 452 ------SKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIAR 505 K+ +E+ LP + +G L T PP +T+A+L+ A+ Sbjct: 457 GRDASRYKDDEEKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALED--- 513 Query: 506 FVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM- 564 G+G +T A + + RG++ ++G + + A+ L E Sbjct: 514 --------------RGIGRPSTYASTVATVQDRGYVLRRGTALVPSWTAFAVVRLLEEHF 559 Query: 565 --ATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L ++++ ++++ Sbjct: 560 GPFIDYDFTAQMEQQLDRMAQGDLARSEYLKNFY 593 >UniRef50_C4ZCE3 DNA topoisomerase n=5 Tax=Clostridiales RepID=C4ZCE3_EUBR3 Length = 1273 Score = 488 bits (1257), Expect = e-136, Method: Composition-based stats. Identities = 178/705 (25%), Positives = 315/705 (44%), Gaps = 73/705 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I EKPS+A+ A VL + + DG+IE G V++WC+GHL+ P++YD +Y +W Sbjct: 5 LIITEKPSVAQEFAKVL-RVSGRNDGYIENGE-YVISWCVGHLVGLVYPESYDMKYKKWR 62 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L DLP +P++++ SV KQ N++ L + + AGD +EGQ + + + ++ Sbjct: 63 LEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGG 122 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + + R I+ + + R I + S + L S + R D+ GIN +R Sbjct: 123 VREGMEE--LRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVM 180 Query: 181 TILGRNAGYQGV-------LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 ++ N ++VGRV T VLG+VV R+ EI NF F+ V Sbjct: 181 SVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFTDAG- 239 Query: 234 ERFTAIWQPSEACEPYQD----EEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 A W+ E ++ +E A ++ ++G+ A + S + AP Sbjct: 240 --VEAEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAP 297 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMN 349 L F+L+ LQ E +K+F +S L + Q LYE KL TYPR+D R L + Sbjct: 298 LLFNLAELQAECSKKFKISPDETLQVAQDLYE-KKLTTYPRTDARVLSSAVAKEIGKNIG 356 Query: 350 AISVHAP------DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAKV 402 + P ++ + + + DD KV H+AIIPT + + LT + V Sbjct: 357 RLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAV 416 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD--EEND 460 + LI R++L F P A + + +D+ K F A ++ L G+ + ++ EE++ Sbjct: 417 FELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESN 476 Query: 461 GTPL----------------------------------PVVAKGDELLCEKGEVVERQTQ 486 L + GDE+ C+ + +T Sbjct: 477 ARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTS 536 Query: 487 PPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGR 546 PP+ +T +++ AM + ++D++L++ ++ + G+GT ATRA II+ L + G+L + Sbjct: 537 PPKRYTSGSMVLAMENAGQLIEDEELREQIKGS-GIGTSATRAEIIQKLVRIGYLNLNKK 595 Query: 547 Y--IHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQ 601 + G+ +F + P MTA+WE L I+ + ++ L + + Sbjct: 596 TQILTPESLGEMVFEVVYMTVPALLNPKMTANWEKGLDGITRGTVDFWEYRGKLESFIRK 655 Query: 602 LIDQ-AKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPAD 645 ++ ++ + ++ +G + + AA R++ K P Sbjct: 656 ETEKMIEQNLRPEIADRISSFAGKN--ARGAAARRKIGVKCPVCG 698 >UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7Q111_ANOGA Length = 1025 Score = 488 bits (1256), Expect = e-136, Method: Composition-based stats. Identities = 129/706 (18%), Positives = 247/706 (34%), Gaps = 105/706 (14%) Query: 1 MR-LFIAEKPSLARAIADVLPKPH-RKGDGFIECGNGQ-------------VVTWCIGHL 45 M+ L +AEK A+ IA +L + ++ +G+ ++T GHL Sbjct: 29 MKYLNVAEKNDAAKTIAGLLSRGSSQRREGYSPYNKIYEFSYNLHGQSIQMIMTSVSGHL 88 Query: 46 LEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSV-TKQLNVIKRFLHEASEIVHAGDP 104 L + + W+ + + + P K ++R + S ++ D Sbjct: 89 LTH----EFLPSFRGWHSCSPEDLFDAPVRKNCPEQYEKIKKTLEREVRGCSALIIWTDC 144 Query: 105 DREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALA 164 DREG+ + E+++ + A + + +V R +++ +++RAI+ L + Sbjct: 145 DREGENIGYEIIEVCR-AVKPQLRVFRAKFSEITAPSIKRAIENLVQPDARQN--DAVNV 201 Query: 165 RARADWLYGINMTRAYTILGRNAG----YQGVLSVGRVQTPVLGLVVRRDEEIENFVAKD 220 R+ D G TR T+ + + ++S G Q P LG V +R +EIENF+ + Sbjct: 202 RSELDLRIGAAFTRFQTLRLQKSFPQDISNNLVSYGSCQIPTLGFVAQRYKEIENFIPQT 261 Query: 221 FFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSY 279 F+++K + + RL + E + P A V + Sbjct: 262 FWKIKLTHTID------------DLTVEFHWSRNRLFDKQCCEAYLMLCQTNPTAKVVNV 309 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K +++ P P L+ +++ ++A+ V+ I +KLY T +I+YPR++ + Sbjct: 310 TQKPKNKWRPTPMDTVELEKLGSRKLKMNAKQVMTIAEKLY-TQGIISYPRTETNMFTGD 368 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENE 399 S + + N K AH I PT NL+ +E Sbjct: 369 MKLAPLVQAQVASDQWGSFAEKVLQWGV--NPRNGKKSDQAHPPIHPTKL--PTNLSGDE 424 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCV-IELDIAKGKFVAKARFLAEAGWRTLLGSKERDEE 458 +VY LIAR +L DA + + + + +F A + E + + + + Sbjct: 425 WRVYELIARHFLACVSRDATGSETIVNVVVAEEEEFTASGLCIHERNYLEVYPYDRWNAK 484 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + G + + E T P T+A L++ M Sbjct: 485 E----IHSYQVGHTFEPTELGLHEGSTTAPNMLTEADLIALMEK---------------- 524 Query: 519 TDGLGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHW 574 G+GT+AT A I + +RG++ + ++ G L M P++ A Sbjct: 525 -HGIGTDATHAEHINTIKERGYIGERDRGFLVPGTLGMGLVEGYEMMELRLAHPELRAGL 583 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLI---------------DQAKRTPVRQFRGI-- 617 E+ L + E + D + + ++ + +TP Sbjct: 584 EADLKLVCEGRKNPNDVLAEQIAKYKEVYRIMSQKARALDRAMGQRLNQTPQEPPPDAGA 643 Query: 618 ---------------VAPGSGGSADKKKAAP--RKRSAKKSPPADE 646 P G + + P Sbjct: 644 SAATATGSAPMREVCKCPKCGHKMCLRTKRDSSGYYLGCVAFPECR 689 >UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SJ74_9FIRM Length = 703 Score = 487 bits (1254), Expect = e-136, Method: Composition-based stats. Identities = 129/671 (19%), Positives = 239/671 (35%), Gaps = 85/671 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ ++ +L + V +GH+ + + + Sbjct: 11 LVIVESPTKAKTVSKMLG-------------SNYKVVASVGHIRDLPKSKMGIDIENNFE 57 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 ++ +K + I A DPDREG+ + + L L Sbjct: 58 PE----------YINVRGKASKIKELKELYKNSENIYLATDPDREGEAISWHIAYLLGLD 107 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R +++ ++++ +I R + L S AR D L G ++ Sbjct: 108 INDNN---RIEFHEITKKSIKESIKNSRKID--MNLVNSQQARRVLDRLVGYKLSPILWK 162 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 ++ LS GRVQ+ L ++ R EEI+NFV ++F++++ E + + Sbjct: 163 KIKSG-----LSAGRVQSATLKIICERQEEIDNFVPEEFWKIEGIHNVQNIEFKSLYYGE 217 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E + + E + + A VV + IV ++ PF+ S LQ EA Sbjct: 218 YENKKIVKKE---IKNEKEALKVVEKTDKDNFIVEDVKKVKKERKPQPPFTTSTLQQEAG 274 Query: 303 KRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 ++ G S+ + I Q+LYE + LI+Y R+D + E A + Sbjct: 275 RKLGFSSSMTMSIAQQLYEGINVGKEGSVGLISYMRTDSTRISSEIVAEAIEYIT----- 329 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 + + DAH + P++ + LT N+ K+Y LI + Sbjct: 330 --ENYGKNYASKGNEYNLKKKNSQDAHEGVRPSSIFRSPEKIKSYLTSNQYKLYKLIWER 387 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 + + I L+ + R+ G+ + S + +E PLP + Sbjct: 388 TVASQMKAESYESTQIVLNSNNCIYKLNGRYTLFDGFSKIYTSSDIKDE----PLPKLEV 443 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 D + EK E + T+P +FT+A+L+ + +G+G +T A Sbjct: 444 KDVINAEKIEKSQHFTKPVANFTEASLVKKLEE-----------------NGIGRPSTYA 486 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQC 586 II L R ++ + + I TD GK + L E T E L +I+E + Sbjct: 487 SIINSLTSRFYILIENKKIIPTDLGKNVNKFLVSNFETIINEKFTMEMEEKLDEIAENKK 546 Query: 587 RYQDFMQPLVGTLYQLIDQAKR-----TPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 ++ + + +++ + P G + KK + Sbjct: 547 DWKKVISDFYAVFETFLKRSEGDSEDYKIKDEVLDEKCPQCGKNLVIKKTKFGRFIGCSG 606 Query: 642 PPADEVGSGAI 652 P + Sbjct: 607 FPDCNYIKKEV 617 >UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1VM20_STRGG Length = 963 Score = 486 bits (1252), Expect = e-136, Method: Composition-based stats. Identities = 135/635 (21%), Positives = 238/635 (37%), Gaps = 90/635 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDS 56 RL I E P+ A+ I L G VV +GH+ + PD Y Sbjct: 13 RLVIVESPAKAKTIKGYLG-------------PGYVVEASVGHIRDLPNGAAEVPDEYTG 59 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 R D+ + Q+ +K+ L E+ E+ A D DREG+ + + Sbjct: 60 EVRR-LGVDVEHDFQPI-YVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWHLQ 117 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + L+ + V R + +++ A+ A+ R ++ + + R D LYG + Sbjct: 118 EVLR----PKVPVHRMVFHEITKDAIRAAVANPRELNQ--RMVDAQETRRILDRLYGYEV 171 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP----- 231 + LS GRVQ+ LVV R+ E F + +++++ T Sbjct: 172 SPVLWKKVMPK-----LSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDA 226 Query: 232 -ADERFTAIWQPSEACEPYQDEEGR-------------LLHRPLAEHVVNRISGQPAIVT 277 TA + Q + L A + ++ V Sbjct: 227 SDPSNLTARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFTVR 286 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 S K S PF + LQ EA+++ G A+ + + QKLYE + ITY R+D L Sbjct: 287 SVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYE-NGFITYMRTDSTTLS 345 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAI 393 + A A + + + LP+ + + +AH AI P+ + Sbjct: 346 DTAVAAARAQVTQL--YGASYLPEKPRTYAGKVK----NAQEAHEAIRPSGDRFRTPAET 399 Query: 394 NLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRT 448 LT ++ ++Y LI ++ + DA +++ D +F A + + G+ Sbjct: 400 GLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMK 459 Query: 449 LLGSKERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIA 504 D ++ LP VA+GD L ++ V T+PP +T+A+L+ + Sbjct: 460 AYVEGADDPNAELDDRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELEE-- 517 Query: 505 RFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM 564 +G +T A II + RG++ KKG + + A+ + L + Sbjct: 518 ---------------REIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKH 562 Query: 565 A---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L +IS + + +++ Sbjct: 563 FGRLVDYDFTARMEDDLDRISRGEAQSVPWLKRFY 597 >UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9S2_9FIRM Length = 754 Score = 486 bits (1251), Expect = e-135, Method: Composition-based stats. Identities = 130/671 (19%), Positives = 236/671 (35%), Gaps = 87/671 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ ++ I L K V +GHL + + + Sbjct: 4 LVIVESPTKSKTIGRFLGK-------------NYTVKASMGHLRDLPKSQFGVDVDHDFE 50 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +K +A +I A DPDREG+ + + L + Sbjct: 51 P----------KYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIAWHLGYLLGVD 100 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 PE R +++ P AV+ AI + + + R D + G ++ Sbjct: 101 PESNC---RISFHEITPHAVKEAIKHPAAID--MDKVDAQQTRRILDRIVGYKLSPLLWR 155 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD-ERFTAIWQ 241 LS GRVQ+ + ++ R +EI+ F ++++ + +FTA Sbjct: 156 KIAKG-----LSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTAEVT 210 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 E ++ + + A V + Q V S K PF+ S+LQ EA Sbjct: 211 KKEG------KKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEA 264 Query: 302 AKRFGLSAQNVLDICQKLYETH--------KLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 KR + + + + Q+LYE LITY R+D +L A + Sbjct: 265 VKRLNFTTKKTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYI----- 319 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 ++ + +AH AI PT+ + L ++ ++Y LI Sbjct: 320 --GEVYGDAYLPKKPNVYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWE 377 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVA 468 + + +V + ++ + A + G+ TL+ KE E P + Sbjct: 378 RTVSCQMAPSVSEVTTLIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKV-PHLK 436 Query: 469 KGDELLCEKG-EVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 +G L + ++ T+PP +FT+ATL+ + G+G +T Sbjct: 437 EGTPLTLISVDDAIQHFTEPPAYFTEATLVKELEE-----------------KGIGRPST 479 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEK 584 A II+ + RG++ K+ + + T+ G L + +AH E+ L ISE Sbjct: 480 YATIIQTILSRGYVAKEAKKVMPTELGMTTIELLTQYFPNLIDVPFSAHMENELDAISEH 539 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQ-----FRGIVAPGSGGSADKKKAAPRKRSAK 639 + + + ++ G + ++ A R + + G K K A Sbjct: 540 KTKKETVLKEFYGPFEKELEIADREIPVKPQEVIVSDVKCEKCGRMMVVKTGRHGKFLAC 599 Query: 640 KSPPADEVGSG 650 P Sbjct: 600 PGFPECRNTKP 610 >UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LVP1_ARATH Length = 926 Score = 486 bits (1251), Expect = e-135, Method: Composition-based stats. Identities = 138/701 (19%), Positives = 249/701 (35%), Gaps = 98/701 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNG--------------QVVTWCIGHLLEQ 48 L +AEKPS+A+++A +L + + N ++T IGHL+E Sbjct: 12 LNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMEL 71 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQ-PRPSVTKQLNVIKRFLHEASEIVHAGDPDRE 107 + RY +W+ D + + ++ ++ ++ +V D DRE Sbjct: 72 ----EFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDRE 127 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + EV+D + A + ++R + L + + A+ LR ++ + AR Sbjct: 128 GENIAFEVVDVCR-AVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLF--AEAVDARQE 184 Query: 168 ADWLYGINMTRAYTILGRNAG--------YQGVLSVGRVQTPVLGLVVRRDEEIENFVAK 219 D G + TR T+L R+ V+S G Q P LG +V R EI+ + Sbjct: 185 IDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPE 244 Query: 220 DFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTS 278 +F+ + Q E + G L A + +P A V + Sbjct: 245 EFWTINCS------------HQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMN 292 Query: 279 YND-KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 + + P P + L+ A++ F LS+++ + + ++LY+ I+YPR++ Sbjct: 293 VPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQA-GFISYPRTETDSFS 351 Query: 338 EEHFAGRHAVMNAISVHAPDLLPQPVVDPDI--RNRCWDDKKVDAHHAIIPTARSS-AIN 394 + + RN AH I PT SS N Sbjct: 352 SRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESN 411 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKE 454 + + VY L+ R YL AV + +E+DIA +F A R + + + Sbjct: 412 WSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRF-- 469 Query: 455 RDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKK 514 E G+ +PV KG + + + T+PP +A LLS M Sbjct: 470 --ESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAG---------- 517 Query: 515 ILRATDGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPEM---ATRPDM 570 +GT+AT I+ L RG+ TK T+ G+AL +M +P++ Sbjct: 518 -------IGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNL 570 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGI------------- 617 A E + ++S + + ++ + + A+ + + Sbjct: 571 RALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDES 630 Query: 618 ----------VAPGSG-GSADKKKAAPRKR-SAKKSPPADE 646 +K + P Sbjct: 631 ESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCR 671 >UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_9FIRM Length = 718 Score = 486 bits (1250), Expect = e-135, Method: Composition-based stats. Identities = 133/677 (19%), Positives = 245/677 (36%), Gaps = 96/677 (14%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 M+ L I E PS ++ I L N +V GH+ + A Sbjct: 1 MKNLVIVESPSKSKTIEKYLG-------------NDYMVVSSKGHIRDLATTGKGGLGID 47 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 + + + + +K ++ I A DPDREG+ + + L Sbjct: 48 VEHDFEP-------TYKISADKRSVVKELKDLAKKSDHIYLASDPDREGEAIAWHLAQVL 100 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 L R + N++ AV A+ R+ +P+ S R D + G +++ Sbjct: 101 GLDVNDEN---RIVFNEITKGAVTEALKHPRTID--IPMVKSQETRRMLDRIIGFKLSKL 155 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAI 239 ++ S GRVQ+ L L+V R++EI F +++++ + A +V ++F A Sbjct: 156 LQSKIKSK------SAGRVQSVALRLIVEREQEIRAFKSEEYWTL-AALVDKDSKKFNAN 208 Query: 240 WQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQI 299 ++ L + + +++R V+S K + +PF S LQ Sbjct: 209 LIRIGG------KKAELKTQQEVDAIISRC--HEFKVSSIEKKVRKKEPRMPFITSTLQQ 260 Query: 300 EAAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 EA+ + G A+ + I QKLYE LI+Y R+D L E+ + Sbjct: 261 EASTKLGFGAKKTMQIAQKLYEGIALQGGNAEGLISYMRTDSTRLSEQFVRDAEQYIEDT 320 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLI 406 + + + DAH AI PT LT ++ K+Y LI Sbjct: 321 --YGKAY-------CGRARQKNSENAQDAHEAIRPTNIQHTPESIKNYLTNDQYKLYKLI 371 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 + L + + +F A LA G+ + E ++ LPV Sbjct: 372 YARTLASLMAPSKSNVVNAIIVSEDCEFSANGSILAFDGYLKIYHDYETVKDE---MLPV 428 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + +G++L + E + T+PP +++A L+ + G+G + Sbjct: 429 LEEGEKLEKVRLEGKQHFTEPPLRYSEARLIKDLEE-----------------KGIGRPS 471 Query: 527 TRAGIIELLFKRGFLTKKG-------RYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 T A II+ L RG+++ + + ++ G+ L E TA E+ Sbjct: 472 TYAIIIDTLQARGYVSLEKSSEGSKTKVFFPSEQGELTDAKLKEFFSNLINVTYTAEMEA 531 Query: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR---QFRGIVAPGSGGSADKKKAAP 633 L +I+ + ++ L++ A + + G + P G + Sbjct: 532 KLDEIAANTLDNIEELKRFYAKFEPLLENAYEHMEKKELERTGELCPECGSELVYRVGRY 591 Query: 634 RKRSAKKSPPADEVGSG 650 K + + P+ Sbjct: 592 GKFISCINFPSCRYTKS 608 Score = 41.5 bits (96), Expect = 0.094, Method: Composition-based stats. Identities = 11/64 (17%), Positives = 17/64 (26%), Gaps = 1/64 (1%) Query: 585 QCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPR-KRSAKKSPP 643 + RY F+ + I K G P G K+K+ + P Sbjct: 631 KGRYGSFLACSNYPTCKYIKNNKPKEEPVPTGENCPECGHPLVKRKSRFGTTFVGCSNYP 690 Query: 644 ADEV 647 Sbjct: 691 KCRY 694 >UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_9BACT Length = 897 Score = 484 bits (1246), Expect = e-135, Method: Composition-based stats. Identities = 122/633 (19%), Positives = 222/633 (35%), Gaps = 91/633 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I +L K V GH+ + Q Sbjct: 6 LVIVESPAKAKTIEKILGK-------------DFEVKASFGHVRDLPQRKLGVD------ 46 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 P + + Q K + +K I A DPDREG+ + + + L+ Sbjct: 47 ----PDNDFEPEYQVSADKKKVIAELKSSAKNCENIYLAPDPDREGEAIAWHLYEILKKQ 102 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + + +R N++ A++ A D+ + + AR D L G ++ Sbjct: 103 --SKAEFKRVTFNEITKSAIKSAFDKAHDVD--MHRVDAQQARRILDRLVGYKVSPLLWK 158 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP--ADERFTAIW 240 + S GRVQT L L+ R++ I F ++++ ++A + + F + Sbjct: 159 -------RNARSAGRVQTVALRLICEREKAIRAFTPEEYWSLQAELKNQAADAQSFISKL 211 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + ++ + + + +V + G V K + PF S LQ Sbjct: 212 DKIDG------KKPHIPNEETSSKIVGELEGSQFRVKDIESKDRKKRPAPPFITSTLQQA 265 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A+ S + + QKLYE T LITY R+D + +E +N I Sbjct: 266 ASSNLRFSPSRTMSLAQKLYEGRDLGSEGTAGLITYMRTDSVAIAKEAQNAAIDFVNHI- 324 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + + P + H AI PT + L ++E K+Y LI Sbjct: 325 -YGSEFSPDK-----PNFYKSKNSAQGGHEAIRPTDVTRTPKKMAPYLNDDELKLYTLIW 378 Query: 408 RQYLMQFCPDAVFRKCVIEL------DIAKGKFVAKARFLAEAGWRTLLGSKER---DEE 458 ++++ A++R+ I + F L G+ + + D E Sbjct: 379 KRFVASQMVPALYRQDSITFLPENIGMSHEYLFKITGSVLIFDGFMKVYNFSDDGSQDGE 438 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + LP + +G+ + + T+PP F++ATL+ + Sbjct: 439 SKDVILPQLKEGEICDLLQLIPKQHFTEPPPRFSEATLVKELE----------------- 481 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWE 575 +G+G +T A II + R ++ K ++ +D G L TAH E Sbjct: 482 ANGVGRPSTYASIIRTIQDREYVFKDKGRLNPSDKGMESCDFLITTLPSLFEVTFTAHME 541 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 +L ++ + + ++ AK Sbjct: 542 ELLDKVEHGDLEWTKMLGDFYSGFKDWLEDAKT 574 >UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms RepID=TOP1_STRCO Length = 952 Score = 484 bits (1245), Expect = e-135, Method: Composition-based stats. Identities = 136/633 (21%), Positives = 238/633 (37%), Gaps = 88/633 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ-----PDAYDS 56 RL I E P+ A+ I L G VV +GH+ + P+ Y Sbjct: 13 RLVIVESPAKAKTIKGYLG-------------PGYVVEASVGHIRDLPSGAAEVPEKYTG 59 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 R D+ + Q+ +K L E+ E+ A D DREG+ + + Sbjct: 60 EVRR-LGVDVEHDFQPI-YVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAWHLQ 117 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + L+ + V+R + +++ A+ A+ R ++ L + R D LYG + Sbjct: 118 EVLK----PKIPVKRMVFHEITKDAIRAAVANPRELNQK--LVDAQETRRILDRLYGYEV 171 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP----- 231 + LS GRVQ+ LVV R+ E F + +++++ T Sbjct: 172 SPVLWKKVMPR-----LSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDA 226 Query: 232 -ADERFTAIWQPSEACEPYQDEEGR-----------LLHRPLAEHVVNRISGQPAIVTSY 279 A Q + Q + L A + + V S Sbjct: 227 SDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSV 286 Query: 280 NDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE 339 K S PF + LQ EA+++ G A++ + + QKLYE + ITY R+D L + Sbjct: 287 ESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYE-NGYITYMRTDSTTLSDT 345 Query: 340 HFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR----SSAINL 395 + A + + + D LP + + +AH AI P+ + L Sbjct: 346 AVSAARAQVTQL--YGADYLPPQPRTYAGKVK----NAQEAHEAIRPSGDRFRTPAETGL 399 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRTLL 450 T ++ K+Y LI ++ + DA +++ D +F A + + G+ Sbjct: 400 TGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAY 459 Query: 451 GSKERDE----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARF 506 D ++ LP VA+GD L E+ V T+PP +T+A+L+ + Sbjct: 460 VEGADDPNAELDDRERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELEE---- 515 Query: 507 VQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA- 565 +G +T A II + RG++ KKG + + A+ + L + Sbjct: 516 -------------REIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFG 562 Query: 566 --TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 D TA E L +I+ + + +++ Sbjct: 563 RLVDYDFTARMEDDLDRIARGEAQSVPWLRRFY 595 >UniRef50_B2VAT6 DNA topoisomerase III family n=1 Tax=Erwinia tasmaniensis RepID=B2VAT6_ERWT9 Length = 722 Score = 483 bits (1244), Expect = e-135, Method: Composition-based stats. Identities = 198/658 (30%), Positives = 319/658 (48%), Gaps = 44/658 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA+ +K G+ EC VVTWC GH+L P A + Y Sbjct: 1 MILTIAEKPELAEIIANAFGNAVKK-QGYYECAGNNVVTWCFGHMLVLTPPAAVNPSYEV 59 Query: 61 WNLADLPIVPEKWQLQPRP----SVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W + DLP+ Q + V +Q +I L ++S ++HAGDPD EG+LLV E+L Sbjct: 60 WKMDDLPMDLTAVSHQVKATENGYVERQYKIICDLLKKSSSVIHAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSN--SEFVPLCVSALARARADWLYGI 174 + V+R L+NDLN A ++AID++ +F+ L + ALARA+ D ++G+ Sbjct: 120 ----WLENYTKPVKRLLLNDLNINAAKKAIDKMEDGNSDKFIRLALKALARAKGDQIFGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 NMTR +T+L + G +G L+ GRVQTP+LGL+V R + + V +++V + D Sbjct: 176 NMTRYFTLLSQRLGGRGKLTCGRVQTPMLGLIVARYKAFNSHVKSYYYDVSSTHNFLKDF 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 I A +G+++ +A+ + G+P+ V S + ++ +APLPF L Sbjct: 236 PLKIIPNDDFAV------DGKIIDPDVAQKIKEACEGKPSSVASVKVEDKATAAPLPFDL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 LQ K +S L++ Q L + I+Y RSDCRYL + +NA+ + Sbjct: 290 LGLQSYMLKD-KISPDETLELTQSLRSNYSAISYNRSDCRYLSSDQHEEAPDTLNALKKY 348 Query: 355 APD-----LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSS-AINLTENEAKVYNLIAR 408 D ++ D + + ++DK + +H AIIPT ++ E KVY I Sbjct: 349 VGDGALNDVINNTSFDISRKGKAFNDKNITSHTAIIPTPNPRGLEKMSAKERKVYEAIVL 408 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG------- 461 +YL+QF D ++ + +D A ++ A A L AGW ++ + N+ Sbjct: 409 RYLLQFVDDKKYKSAKVVVDCAGYQYSASATRLISAGWSSIEADDSDESNNNDGEDSQPL 468 Query: 462 -TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 + ++ G++ C + + +T+P +T T L + ++++V D +KK+L + D Sbjct: 469 FESISALSNGEQSSCTGVIISKAETKPLPLYTMKTFLEDLKRVSKYVSDPRIKKLLLSKD 528 Query: 521 --------GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTA 572 G+GT ATR+ II+ L G+ T + + T+ G SLP T PDMTA Sbjct: 529 EGKKGERGGIGTPATRSTIIKNLENTGYYTIQSNKLIPTEKGIKFIESLPVSVTAPDMTA 588 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRG----IVAPGSGGSA 626 W T I + + DF+ + T+ +L+ ++Q GG Sbjct: 589 LWHEQQTMILDGEMELSDFIININQTVAELMKADVTEGMKQVADSQPKGKCFCCGGDM 646 >UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBN6_ELUMP Length = 765 Score = 483 bits (1244), Expect = e-135, Method: Composition-based stats. Identities = 132/686 (19%), Positives = 256/686 (37%), Gaps = 93/686 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ + I+ +L VV GH+ + + + Sbjct: 20 LVIVESPTKQKTISKILGA-------------DYVVKSSFGHVRDLPSKEIGVDEKNGFK 66 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + P K ++ +++ + + A DPDREG+ + +++ L++ Sbjct: 67 P----------KYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAWHLVELLKIP 116 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 E +++R +++ P AV+ + D R+ ++ L + AR D L G ++ Sbjct: 117 VE---KIRRIFFHEITPAAVKASFDHARNINK--DLVDAQQARRVLDRLVGYKLSPLLWK 171 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD-ERFTAIWQ 241 G LS GRVQ+ + L+ R +EIENF ++++ + + + + +F A Sbjct: 172 KIT-----GGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARML 226 Query: 242 PSEAC------------EPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 E Y+ + V + + P V+ K + A Sbjct: 227 KWRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAK 286 Query: 290 LPFSLSALQIEAAKRFGLSAQNVLDICQKLY-------ETHKLITYPRSDCRYLPEEHFA 342 PF S+LQ EA + G +Q + Q LY E LITY R+D + ++ + Sbjct: 287 PPFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQS 346 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTAR-----SSAINLTE 397 + + D +P + +AH +I PT S L+ Sbjct: 347 QTKKFI--AGKYGDDFVP----PTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSA 400 Query: 398 NEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK---FVAKARFLAEAGWRTLLGSKE 454 ++ K+Y LI +++ DAVF +++ K + A R + G+ ++ + Sbjct: 401 DQYKLYELIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDD 460 Query: 455 RDEENDGTP-LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLK 513 +EE++G+ LP + +GD+L +T PP ++ +A+L+ + Sbjct: 461 SEEEDEGSALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEK----------- 509 Query: 514 KILRATDGLGTEATRAGIIELLFKRGFLTK--KGRYIHSTDAGKALFHSLPEMA---TRP 568 G+G +T A I+ + R ++ + K + TD G + L + Sbjct: 510 ------HGIGRPSTYAPTIKTILDRKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDL 563 Query: 569 DMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR---QFRGIVAPGSGGS 625 TA E L I+E + + + + A + R + P G Sbjct: 564 SYTAGIEEKLDDIAEGDNDWVKVIGDFYEGFKKDLATADKDMQRAAPKPSDEKCPLCGSP 623 Query: 626 ADKKKAAPRKRSAKKSPPADEVGSGA 651 +++ + A + P + Sbjct: 624 MVIRRSRFGEYLACSTYPECKGKINL 649 >UniRef50_B3DRF3 Topoisomerase III n=8 Tax=Bifidobacterium RepID=B3DRF3_BIFLD Length = 719 Score = 483 bits (1243), Expect = e-134, Method: Composition-based stats. Identities = 182/686 (26%), Positives = 299/686 (43%), Gaps = 69/686 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAY-DSRYA 59 M+L IAEK S+A AIA L + DG ECG +VTW GHL++ A P+ Y D + Sbjct: 1 MKLVIAEKKSVATAIAQALCAAPVQRDGCYECG-QLLVTWAQGHLIDLAMPEDYKDRDWR 59 Query: 60 RWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDE 114 +W+L LP+ P +W++ + I R + + +V+A DPDREG+ + Sbjct: 60 KWSLDTLPVDPSGHWQWKISEERGAGSRYRQIVRLIRRTDVDCLVNACDPDREGEAIFRR 119 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + D + R + L +A++ A ++ SE+ L SA R++ADWL G+ Sbjct: 120 IADM----EGSHKPELRLWVASLEAEAIQAAWRAMKPESEYQGLAWSAEIRSKADWLIGM 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 N +RAY++L Y SVGRVQTP L ++ RD +I N F+ V A + Sbjct: 176 NASRAYSLL-----YNARFSVGRVQTPTLAMIAERDRQIRNHKPVPFWTVIADMGG---- 226 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 ++ R+ + A + + + S N +R ++ P + L Sbjct: 227 --------------WRLSSERIDSKDAAMLLCGQAEHGRFRIMSVNRRRVNDRPPRLYDL 272 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + LQ + ++ +G++A L Q LYE KL TYPR+D RY+ + A++ + + Sbjct: 273 TGLQKDMSRMYGMTAARTLQALQHLYEL-KLATYPRTDSRYITHDDLETLTALLESGRLA 331 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA---INLTENEAKVYNLIARQYL 411 + + + +DKKV H AI+PT + A L ++E KV I R+ Sbjct: 332 QGFVTREGIPGHPRPELTVNDKKVAGHTAILPTMQLDAGKLEGLDDDERKVMTRIVRRMW 391 Query: 412 MQFCPDAVFRKCVIEL---DIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP--- 465 D V ++ D +F +++ AGW+ + + E++ T P Sbjct: 392 EAVGDDHVHIVTEVKARLSDDTDREFSSRSDETVSAGWKAVETGHGPEPEDEETANPAGG 451 Query: 466 ------VVAKGDEL-LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR- 517 + +G + K V E +T+PP+ FT+ATLL+AM +R V+DK+LK L Sbjct: 452 RNVIPSNLMEGGVIRPVGKVTVEEGETRPPKPFTEATLLAAMEHASRCVEDKNLKAALDD 511 Query: 518 ---ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHW 574 + G+GT ATRA IE L + + +KGR +H+T G+ L + +TA Sbjct: 512 DESHSGGIGTPATRADTIEKLVRSKLVERKGRQLHATTEGERLTDVVEPRLKDVLLTARM 571 Query: 575 ESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT----------PVRQFRGIVAPGSGG 624 E L+ + + + M ++ A P G Sbjct: 572 EQALSDVEHGKRGPSEVMDMFHREALRIPADATANLKADAVTRTANTDAQEWGDCPRCGQ 631 Query: 625 SADKKKAAPRKRSAKKSPPADEVGSG 650 K + + ++ G Sbjct: 632 PVRK----TGRMWQCSTNKTEKTKDG 653 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 483 bits (1243), Expect = e-134, Method: Composition-based stats. Identities = 147/658 (22%), Positives = 250/658 (37%), Gaps = 90/658 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ IA L +G V +GH+ + +P + Sbjct: 48 KLVIVESPAKAKTIAQYLG-------------SGYEVQASVGHIRDLIEPKNLPPELKKG 94 Query: 62 NLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 L + E + K + +KR L +A E+ A D DREG+ + +L Sbjct: 95 TLGKFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWHLLQV 154 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ + V+R + +++ +A+ERA D R L + R D LYG ++ Sbjct: 155 LK----PKVPVKRMVFHEITKEAIERARDSTRDID--TALVDAQETRRILDRLYGYEVS- 207 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT-PADERFT 237 +L R G LS GRVQ+ LVV R+ E FV ++++ A + + F Sbjct: 208 --PVLWRKVGPG--LSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFD 263 Query: 238 AIWQPSEACEPYQ----DEEGRLLHRP--------LAEHVVNRISGQPAIVTSYNDKRES 285 A + D++G L + A R P V S K + Sbjct: 264 ARLVRIDGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYT 323 Query: 286 ESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRH 345 PF+ S LQ EAA++ SA+ + + Q LYE + ITY R+D L ++ Sbjct: 324 RRPAAPFTTSTLQQEAARKLRFSARQTMSVAQSLYE-NGYITYMRTDSPSLSQQAINAAR 382 Query: 346 AVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARSSAINLTENE 399 A ++ P+ +P +++ +AH A+ P T + A L N+ Sbjct: 383 K--QAAELYGPETVPDKPRLYAGKSK----NAQEAHEAVRPAGETFRTPQQLASTLRGND 436 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKG------KFVAKARFLAEAGWRTLLGSK 453 K+Y+LI ++ + DA + + +F A + G+ Sbjct: 437 HKLYDLIWKRTIASQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEES 496 Query: 454 ERDE-----ENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 +E E LP + KG +L + +T PP +T+A+L+ + + Sbjct: 497 RDEERHGAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELG---- 552 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATR- 567 +G +T A II + RG++T +G + ++ L E T Sbjct: 553 -------------IGRPSTYAAIISTIVDRGYVTPRGTALVPNWIAFSVVRLLEEFFTEL 599 Query: 568 --PDMTAHWESVLTQISEKQCRYQDFMQPLV------GTLYQLIDQAKRTPVRQFRGI 617 D TA E L +I+E D+++ L ID ++ + Sbjct: 600 VQYDFTAGMEDDLDRIAEGAAERVDWLKGFYYGNDAHKGLRPTIDNLGEIDAKEINSL 657 >UniRef50_A6LRS2 DNA topoisomerase n=14 Tax=Firmicutes RepID=A6LRS2_CLOB8 Length = 722 Score = 482 bits (1241), Expect = e-134, Method: Composition-based stats. Identities = 175/682 (25%), Positives = 304/682 (44%), Gaps = 64/682 (9%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD + DG+ E GNG +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADAF-NVKTRRDGYFE-GNGYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFLHE--ASEIVHAGDPDREGQ 109 P +PE + + + KQL +IK + + IV A D DREGQ Sbjct: 61 RFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ Y ++ ++ + R L+N+ P V+ ++ L+ N E PL + + R +D Sbjct: 121 VIADELFGYFKV----KKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T+ + +++GRV P L ++ RD+EIENF A ++++ ++ Sbjct: 177 WIIGINLTSVSTLKYKFE-ENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T A+E F ++ Y+++ + + + ++R+ G A + + + E P Sbjct: 236 TSANEEFEGLY--------YENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPP 287 Query: 290 LPFSLSALQI-EAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE KL TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYE-KKLTTYPRTASVVLEESLKDRAKKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + P + + R +D KV++H AI PT + L+ +E VY+ I Sbjct: 347 NTLKAGLPY---EKDIKFSTSKRIFDSSKVESHSAITPTYIKPS-GLSSDEKIVYDAIKN 402 Query: 409 QYLMQFCPDAVFRKCVIELDIA----KGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++MQF P A F + + L G FV+K + GW+ + E+ L Sbjct: 403 RFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVV-----EKIESKDVIL 457 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ-----DKDLKKILRAT 519 P + + + +V +PP++ T+ TLL M + ++ +++ + + + Sbjct: 458 PKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSG 517 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVL 578 +GT ATRA I+ L G+L KG+ + T+ G+ L + P + + T E L Sbjct: 518 FSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTL 577 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKR-----------TPVRQFRGIVAPGSGGSAD 627 + I + + +F++ + Q ++ K+ P P G Sbjct: 578 SDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVI 637 Query: 628 KKKAAPRKRSAKKSPP-ADEVG 648 K + + Sbjct: 638 ----EGEKSFGCSNWKNGCKYT 655 >UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VJB5_9BACT Length = 739 Score = 481 bits (1239), Expect = e-134, Method: Composition-based stats. Identities = 140/668 (20%), Positives = 240/668 (35%), Gaps = 83/668 (12%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A I+ L N V +GH+ + + + + + + Sbjct: 5 LIIVESPAKAGTISKFL-------------KNQFSVKASMGHIRDLPKRELGVNVHQGFK 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + +K + +K A + A D DREG+ + + + L+ Sbjct: 52 PV----------YIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIAWHLSETLKKE 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + V R + N++ QA+ AI + + AR D L G ++ Sbjct: 102 LN-NKPVYRIVFNEITSQAINEAIKNPGQID--MAKVEAQQARRILDRLVGYEISPLLWK 158 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ L L+ R+ EI+ FV K++++++A F A+ + Sbjct: 159 VITKD-----LSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVLEK 213 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E ++ + A +V AI++ + PF S LQ EA+ Sbjct: 214 IEG------KKVEIPDEKSAIEIVENSQNAEAILSEIKRSNRNVEPLPPFITSTLQQEAS 267 Query: 303 KRFGLSAQNVLDICQKLYETH-------KLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 K G AQ + I Q LYE LITY R+D + EE ++ Sbjct: 268 KILGFQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLI------- 320 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQY 410 + + +V P +R DAH AI PT LT+ + K+Y LI +++ Sbjct: 321 KERFGKELVHPKVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRF 380 Query: 411 LMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKG 470 + ++++ K +FV+ + E G+ AK Sbjct: 381 IATQMIPVKLLSTSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQ--DYAKN 438 Query: 471 DELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAG 530 D L E + T P +T+A+L+ + G+G +T A Sbjct: 439 DVLEHSPLEKTQHFTTSPARYTEASLIKELE-----------------AKGIGRPSTYAT 481 Query: 531 IIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCR 587 IIE L KR ++T + + T G + L + TA E+ L ++ Sbjct: 482 IIETLRKRKYVTMEKKAFLPTQLGSDVNRFLVDKFDYLFNVQFTAEMETKLDEVEYSNIA 541 Query: 588 YQDFMQPLVGTLYQLIDQA----KRTPVRQFRGIVAPGSG-GSADKKKAAPRKRSAKKSP 642 + + +Q L LI Q ++ Q GIV G+ K + + Sbjct: 542 WNEVVQEYYDQLVALIRQVDVKKEKNNFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRF 601 Query: 643 PADEVGSG 650 P + Sbjct: 602 PQCKNTKN 609 >UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EA7F Length = 901 Score = 481 bits (1238), Expect = e-134, Method: Composition-based stats. Identities = 140/675 (20%), Positives = 246/675 (36%), Gaps = 71/675 (10%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNG--------------QVVTWCIGHLLE 47 L +AEK A+ I+ L K + + N V+T GHLL Sbjct: 3 ILNVAEKNDAAKNISFFLSKGSARKRESLSVYNKIYEFEFKLFNQNCKMVMTSVSGHLLN 62 Query: 48 QAQPDAYDSRYARWNLADLPIVPEKWQLQPR-PSVTKQLNVIKRFLHEASEIVHAGDPDR 106 P + W+ D + + K N +K + ++ D DR Sbjct: 63 YCFP----PTHKNWSTTDPSSLFTVPVNKFCAKENFKTQNNLKNEVKYCDTLIIWTDCDR 118 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + E++D + + ++ R +++ +V RAI+ L ++ L + R Sbjct: 119 EGENIGFEIIDVCK-KVKPNIKIYRAKFSEITSASVMRAINNLEMPNK--SLSDAVDVRM 175 Query: 167 RADWLYGINMTRAYTILGRNAGYQG----VLSVGRVQTPVLGLVVRRDEEIENFVAKDFF 222 D G TR ++ + V+S G Q P LG VV R + I F+++ F+ Sbjct: 176 ELDLRIGAAFTRFQSLYLQKKFPDNFKSTVVSYGSCQFPTLGFVVERFKNISQFISEPFW 235 Query: 223 EVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYND 281 ++ + + + E R+ + E + ++ A V + Sbjct: 236 RIEVKDNSNKN-----------LIVDFNWERNRMFDKSCCEVLYDKCIESNLAKVIKVDS 284 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K +S+ P P L+ A+K+ ++A+ L +KLY T I+YPR++ P+E Sbjct: 285 KPKSKYRPKPLDTVELEKLASKKLKINAKLALKTAEKLY-TQGYISYPRTETNIFPKELD 343 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 + + + +VD N K AH I P + NLT E Sbjct: 344 LRPLVQRQTTDSNWGEFALKVLVDGP--NPNQGTKSDQAHPPIHPIKYA--SNLTGVEKN 399 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 +Y LI R +L +A + +E+D+A F AK + + + + + Sbjct: 400 IYELIVRHFLACLSKNAEGIETAVEIDLANEIFTAKGLMITARNYLDVYPYDVWNAKEIN 459 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 GD +VE +T PP T+A L++ M G Sbjct: 460 L----YNVGDVFKPA-VSLVEGKTNPPELLTEADLIALMEK-----------------HG 497 Query: 522 LGTEATRAGIIELLFKRGFLTKKG-RYIHSTDAGKALFHSLPE---MATRPDMTAHWESV 577 +GT+AT A IE + R ++ K +Y G L +P++ A E+ Sbjct: 498 IGTDATHADHIETIKARFYVGLKNDKYFVPRTLGMGLVEGYNNVGFEMAKPNLRAELEAD 557 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRS 637 L+ I+ + QD + + + + K F I + G + + Sbjct: 558 LSSITRNEKMPQDVLNKHINKYKNIFEVVKTNSKNLFEIINSYIQGNNPI--SSEKENNV 615 Query: 638 AKKSPPADEVGSGAI 652 K E G+ I Sbjct: 616 PKSPMNCRECGNPMI 630 >UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei RepID=Q83FM2_TROWT Length = 841 Score = 480 bits (1236), Expect = e-134, Method: Composition-based stats. Identities = 137/649 (21%), Positives = 247/649 (38%), Gaps = 84/649 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ ++ L +G VV +GH+ + P R Sbjct: 3 KLVIVESPTKVSSVGRYLG-------------DGYVVMSSVGHIRDLPAPSGLTPDLKRS 49 Query: 62 NLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDY 118 A + E + + K + ++ L+ + E++ A D DREG+ + ++ Sbjct: 50 AHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWHLVQV 109 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 L+ V+R + +++ +A+ A+ R E L + AR D LYG ++ Sbjct: 110 LK----PTVPVRRLVFHEITREAIAYALQHPRPIDE--NLVDAQEARRILDRLYGYELSP 163 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 R LS GRVQ+P L+V R+ E NF + ++ V A + F+A Sbjct: 164 VLWKKVRPG-----LSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVD-SDVFSA 217 Query: 239 IWQ----------PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAI-VTSYNDKRESES 287 + +L + L + ++ + + A+ V + + K S + Sbjct: 218 SLTLFGERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRN 277 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PF S LQ +AA + G SA+ + Q+LYE ITY R+D L + + A Sbjct: 278 PYAPFITSTLQQDAAHKLGFSAKRTMRTAQQLYE-KGFITYMRTDSPRLSLQAISAARAQ 336 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA------RSSAINLTENEAK 401 + + + + LP + + +AH AI PT S L+ + + Sbjct: 337 VELL--YGREFLPDSPRTYGAKAK----NAQEAHEAIRPTGEVFERPESIESVLSVDCMR 390 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDI---AKGKFVAKARFLAEAGWRTLLGSKERDEE 458 +Y+LI R+ + A + L + FV L E G+ + E ++ Sbjct: 391 LYDLIWRRTIASQMVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVY---EGLQD 447 Query: 459 NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 + LP + GD++ V T PP +T+A+L+ + + Sbjct: 448 LNSKLLPNLQVGDQVTLVDVRAVGHTTLPPPRYTEASLVKVLEELG-------------- 493 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWE 575 LG +T A I+ + +RG+ + R + ++ + L D TA+ E Sbjct: 494 ---LGRPSTYALILSTIQERGYAHLRNRMLVPDWLAFSVVNLLENFFSRLIDYDFTANLE 550 Query: 576 SVLTQISEKQCRYQDFMQPLV------GTLYQLIDQAKRTPVRQFRGIV 618 L +I+ D+++ L ++I AK R I Sbjct: 551 DQLDEIALGSQNRSDWLRKFYFGDDNLPGLKEIISGAKDIDARAINSIP 599 >UniRef50_C9RKZ2 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ2_FIBSS Length = 1049 Score = 480 bits (1236), Expect = e-134, Method: Composition-based stats. Identities = 197/700 (28%), Positives = 323/700 (46%), Gaps = 66/700 (9%) Query: 1 MRLFIAEKPSLARA-----IADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYD 55 M L +AEKPS+A + + + +GDG + G +TWC+GHL+ A DAY Sbjct: 1 MILLVAEKPSVANQHYKPMLERIEGEKFTQGDGCL-IGKNHCITWCVGHLITLAPLDAYP 59 Query: 56 SRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEV 115 W L++LP++PEK++L S KQL V++ + A +V+ D REG L+ D + Sbjct: 60 GFEGGWRLSNLPLLPEKFKLMEIESTRKQLGVVRDMMARADVLVNGADAGREGNLIFDLI 119 Query: 116 LDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGIN 175 LDY +++Q++R +N + +++A L +E + L +A R RADW+ G+N Sbjct: 120 LDYT--PDFRKKQIKRLWVNSYVAKDLDKAWKNLEDATERLNLSYAARLRQRADWMVGLN 177 Query: 176 MTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAH-------- 227 TRAYT+ AG ++SVGRVQTP L LVV RD +E F ++ V Sbjct: 178 ATRAYTL---TAGRGKMISVGRVQTPTLNLVVERDAIVEQFKELFYYSVVGTWKGFQAQL 234 Query: 228 ----IVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAIVTSYNDK 282 + T + + A + + A+ V+++ S + A + + + Sbjct: 235 VKSETKEEKGDSGTPVDEKVAADKQSNLKVAIFEKEEPAQAVIDKCSPPEEAAIAKVDIQ 294 Query: 283 RESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFA 342 ++ + PF L+ LQ E KRF SAQ VLD Q LYE KL+TYPR+D +YLP+ Sbjct: 295 QKKQFPQKPFDLTELQKEGNKRFKYSAQQVLDCAQNLYE-KKLLTYPRTDSQYLPDTMQQ 353 Query: 343 GRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV 402 +A+ ++ + + D + + KV H AIIPT NL E E + Sbjct: 354 EAYALAQRLASPQEKSV---MRDGNENFVFINSSKVTDHFAIIPTGEEPQ-NLPEMEENI 409 Query: 403 YNLIARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGS--------- 452 Y L +++ + V+ + + LD A F K + + G+R L+ Sbjct: 410 YKLAKERFVQAWLKPYVWSEMEVLLDAANAEIFRLKLKRNEDLGFRALVKEEKKKPSKKK 469 Query: 453 --------------------KERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFT 492 D N P GD + E+ +++ P++FT Sbjct: 470 KGDAGSESGDAKGADSEGKGDGDDITNIVETFPEWNLGDHAPFDSLELQKKKKSKPKYFT 529 Query: 493 DATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTD 552 +ATLL+AM + +++++L + ++ GLGT AT+AGIIE L KRGF+ + Y+ ST Sbjct: 530 EATLLAAMKTAGKQIENEELAEAMKE-RGLGTPATQAGIIETLKKRGFIEAQKNYLVSTQ 588 Query: 553 AGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR 612 G+ + + E P+MT WE L+Q+ + + +F +V + +L + ++ Sbjct: 589 RGREVIELMDEKVKSPEMTGEWEFKLSQVEKGKLTPIEFRDGIVNYVKELFEHLRQKYGS 648 Query: 613 QFR------GIVAPGSGGSADKKKAAPRKRSAKKSPPADE 646 QF I P + ++ + A Sbjct: 649 QFERETVTDAIPCPKCSSPLEIAPWGYVCKNEECGFKAGH 688 >UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1_FRASC Length = 1049 Score = 479 bits (1234), Expect = e-133, Method: Composition-based stats. Identities = 139/658 (21%), Positives = 231/658 (35%), Gaps = 111/658 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS---RY 58 RL I E P+ A+ IA L G V IGH+ + + A + Sbjct: 81 RLVIVESPAKAKTIAGYLG-------------PGWQVESSIGHIRDLPRSAADVPAAHKG 127 Query: 59 ARWNLADLPIV-PEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W + + + P Q++ +K + +ASE+ A D DREG+ + +L Sbjct: 128 KPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAWHLLQ 187 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ V+R + +++ PQA++RA+D R + L + R D LYG ++ Sbjct: 188 TLK----PTVPVKRMVFHEITPQAIQRAVDNPRDIDK--NLVNAQETRRILDRLYGYEVS 241 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHI--------- 228 LS GRVQ+ ++V R+ F + +++ ++ Sbjct: 242 PVLWKKVMPR-----LSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAW 296 Query: 229 -------------------------VTPADERFTAIWQPSEACEPYQDEEGRL------- 256 TP A+ A G+L Sbjct: 297 SGADGTPGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTR 356 Query: 257 LHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDIC 316 L A + R++ V S K S PF S LQ EA ++ S+Q + + Sbjct: 357 LDEATARSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVA 416 Query: 317 QKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDK 376 Q+LYE + ITY R+D L + A ++ + P+ +P + + Sbjct: 417 QRLYE-NGYITYMRTDSTNLSKTALTAARAQAASL--YGPEYVPARPRTYAKKVK----N 469 Query: 377 KVDAHHAIIP------TARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIEL--- 427 +AH AI P T L + ++Y LI ++ + DA I L Sbjct: 470 AQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGAT 529 Query: 428 --DIAKGKFVAKARFLAEAGWRTLLGSKERDE----ENDGTPLPVVAKGDELLCEKGEVV 481 +F A + + G+ D E+ LP V +GD L Sbjct: 530 SSAGEDAEFSASGKVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPR 589 Query: 482 ERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL 541 T PP FT+A+L+ + + +G +T A II + RG++ Sbjct: 590 GHTTSPPARFTEASLVKTLEELG-----------------IGRPSTYASIIGTIQDRGYV 632 Query: 542 TKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 KKG + + A+ L + TA E L I+ D++ Sbjct: 633 WKKGSALVPSFVAFAVVGLLEDHFTRLVDYRFTATMEDDLDDIAAGTAASTDWLTRFY 690 >UniRef50_C5REU1 DNA topoisomerase n=3 Tax=Firmicutes RepID=C5REU1_CLOCL Length = 730 Score = 479 bits (1234), Expect = e-133, Method: Composition-based stats. Identities = 178/672 (26%), Positives = 313/672 (46%), Gaps = 53/672 (7%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IA+ L K + + DG++E GNG +TW GHLL+ YD + A+W Sbjct: 3 KVIIAEKPSVAKNIAEAL-KSNIRKDGYLE-GNGYYITWAFGHLLQLYDAKDYDEKMAKW 60 Query: 62 NLADLPIVPEKWQLQPRPS----------VTKQLNVIKRFLH--EASEIVHAGDPDREGQ 109 + + P +P+ ++ + + KQL +I+ ++ + ++ A D DREGQ Sbjct: 61 KMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ D + YL++ ++ V R L N+ V + +++++ N+E L + ++R AD Sbjct: 121 IIGDIITGYLKV----KKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWAD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W GIN+T T+ + G L++GRV P L ++ RD+EI NFV ++F++ A Sbjct: 177 WTIGINLTSVATLKYQR-GKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 T + + + E + + + R + + ++ G ++ +++ E P Sbjct: 236 TSDNIEYEGAYIEKEQEKEQEKFKER----EKLDEISKKMKGCTGVIVDKQTEKKKEYPP 291 Query: 290 LPFSLSALQ-IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE K ITYPR+ L E V+ Sbjct: 292 YLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYE-KKYITYPRTASVVLEESLADRAAKVL 350 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + P Q V R +D+ KV++H AIIPT L+ +E KVY+ I Sbjct: 351 NTLKKSLPF---QEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKT-LSGDEEKVYSAIKN 406 Query: 409 QYLMQFCPDAVFRKCVIELDIA----KGKFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++ QF P A + I I G F++K + GW+ + E+ T L Sbjct: 407 RFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKV-----EKIESKDTIL 461 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL---RATDG 521 P V DE+ K +V T+PP+ T+ TLL M + ++ +++ + Sbjct: 462 PFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFS 521 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQ 580 +GT ATRA I+ L G++ +G+ + ++ G L + P + + T E L Sbjct: 522 IGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLAD 581 Query: 581 ISEKQCRYQDFMQPLVGTLYQLIDQA---KRTPVRQFRGI--------VAPGSGGSADKK 629 + + + +DF++ + I+Q K + Q+ G P G + Sbjct: 582 MEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEG 641 Query: 630 KAAPRKRSAKKS 641 K + + Sbjct: 642 KIGFGCSNWRSG 653 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 479 bits (1233), Expect = e-133, Method: Composition-based stats. Identities = 162/674 (24%), Positives = 275/674 (40%), Gaps = 74/674 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRK---GDGFIE---CGNGQVVTWCIGHLLEQAQPDAYDS 56 L I EKPS+A+ IA+ L K +K G + E G +V +GHL + + + Sbjct: 8 LIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKE--NK 65 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + + + D+ VP + + V K + +K+ +A E A D D EG+L+ L Sbjct: 66 EFGFYPVFDIKWVPASVD-KGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHAL 124 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 Y R++ +R + L + + RA + L + +R DW +GIN+ Sbjct: 125 KYCCG----REKAKRMRFSSLTKKEIVRAFENPDEID--YGLVDAGESRHILDWYFGINL 178 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 +RA R +SVGRVQ P L + R+ EI+ F+ K ++ ++A + Sbjct: 179 SRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLK------- 231 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLS 295 E+ + + A++V +I + A V + PF L Sbjct: 232 --------DNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLPPFDLG 283 Query: 296 ALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 LQ EA F +S + +I QKLYE + LI+YPR+ + LP++ ++N I H Sbjct: 284 TLQREAYSYFKISPKETQEIAQKLYE-NALISYPRTSSQKLPKD-RKYLEDILNIIKNHP 341 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFC 415 + + K+ AH AI L+E E ++Y+LIAR+ L F Sbjct: 342 VYGKWAERILKENLKPVEGKKEDPAHPAIHIVDI-PKEELSEKEKEIYDLIARRTLAAFW 400 Query: 416 PDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLC 475 +A +++DI KF + GW + + DE LP + K D + Sbjct: 401 DNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDE----IELPPLKKNDIIKV 456 Query: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535 EK + ++TQPP+ +T A+++ + GLGT+ATRA II+ L Sbjct: 457 EKITITRKETQPPKRYTVASIIKELEK-----------------RGLGTKATRAEIIDKL 499 Query: 536 FKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQDFM 592 KRG++ + TD G ++ +L MT E L +I ++ + D + Sbjct: 500 IKRGYV-IDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVL 558 Query: 593 QPLVGTLYQLIDQAKRTP---------------VRQFRGIVAPGSGGSADKKKAAPRKRS 637 L +++++ K+ + P GG + + Sbjct: 559 DEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFV 618 Query: 638 AKKSPPADEVGSGA 651 + P +V Sbjct: 619 GCSNYPECDVKYSL 632 Score = 46.9 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 5/47 (10%), Positives = 11/47 (23%) Query: 605 QAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 + ++ P GG ++ K + P Sbjct: 707 KYTEPINKKEVVGKCPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKL 753 Score = 43.8 bits (102), Expect = 0.024, Method: Composition-based stats. Identities = 7/46 (15%), Positives = 13/46 (28%), Gaps = 1/46 (2%) Query: 606 AKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGA 651 K+ V++ + P G KK + P + Sbjct: 668 LKQVEVKE-EDRICPKCGAKLILKKGVYGAFYGCSNYPKCKYTEPI 712 >UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VSX3_NAEGR Length = 1015 Score = 479 bits (1232), Expect = e-133, Method: Composition-based stats. Identities = 126/671 (18%), Positives = 247/671 (36%), Gaps = 71/671 (10%) Query: 3 LFIAEKPSLARAIADVLP-KPHRKGDGFIECGNGQVVTW-------------CIGHLLEQ 48 L +AEKP A+ IA +L ++ +G + + +GHL+E Sbjct: 25 LCVAEKPEAAKQIATILSAGKFQRREGKSKFNKIFEFEYRMNGVVVTMSVTSVLGHLMEL 84 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQ---PRPSVTKQLNVIKRFLHEASEIVHAGDPD 105 +D + W D + + + +++ A++++ D D Sbjct: 85 ----GFDPKLKSWTSCDPITLMDPATPVFRNVPEKNLEIQQNLEQEARYATKLLLWLDCD 140 Query: 106 REGQLLVDEVLDYLQLAPEK----RQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS 161 REG+ + EV++ + + R ++ A+ RAI L + + + Sbjct: 141 REGENIAFEVIEVCKKVNRSLSIENDSILRARFSEFTAAAINRAIRNLERPNVLDSM--A 198 Query: 162 ALARARADWLYGINMTRAYTILGRNAGYQ---GVLSVGRVQTPVLGLVVRRDEEIENFVA 218 R D G + TR ++ + +S G Q P LG VV+RD I+NF + Sbjct: 199 VDTRQELDLRIGASFTRFQSLRLKKKFQGITADYISYGPCQFPTLGFVVKRDLIIKNFES 258 Query: 219 KDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVT 277 + F+ + E + + GRL + + Q A V Sbjct: 259 ESFWTLNCTHDMG-----------EEGKAQFLWKRGRLFDQLTCLVIYELCVEAQRARVV 307 Query: 278 SYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLP 337 + KR + P P + LQ A+++ + + + + + LY I+YPR++ Sbjct: 308 NVEKKRRYKYRPDPLNTIELQKLASQKLKMGSHETMKVAESLYN-KGFISYPRTETNNYN 366 Query: 338 EEHFAGRHAVMNAISVHA-PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLT 396 + ++N + + +++ + + AH I P N Sbjct: 367 QFQDDDLKRLVNEHTSNPTWGGYASDLLNGGYQKPPSGKQDDKAHPPIHPLKGDCNSN-D 425 Query: 397 ENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERD 456 E +Y LIAR +L DAV + + + IA +F + + + + Sbjct: 426 SKEQALYELIARHFLACCSKDAVGAETKVIISIANEEFTCSGLMVEQKNFLEIWKYDR-- 483 Query: 457 EENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKIL 516 +PV G E + + +T+PP H +++ L+SAM Sbjct: 484 --WSDKSIPVFNAGQEFIPTSLLMDHGETRPPPHLSESDLISAM---------------- 525 Query: 517 RATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAH 573 ++G+GT+AT A I+ + +RG++ KKG +T+ G AL + P++ + Sbjct: 526 -DSNGIGTDATVAQHIKTIQERGYVIKKGNRFEATNLGMALLQGYDLIGYELSTPNLRSK 584 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP--VRQFRGIVAPGSGGSADKKKA 631 E + IS+ + + + + + Q ++ + + P G + Sbjct: 585 MEKDMLSISKGEQSKEAVIHQSLSMYKHVYIQICKSAYLLDKAVQQHFPTLGEGQSRVLG 644 Query: 632 APRKRSAKKSP 642 + K+P Sbjct: 645 RGFSLCSCKNP 655 >UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA) III alpha n=3 Tax=Neoptera RepID=UPI0000DB782E Length = 958 Score = 478 bits (1230), Expect = e-133, Method: Composition-based stats. Identities = 145/697 (20%), Positives = 263/697 (37%), Gaps = 98/697 (14%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNG--------------QVVTWCIGHLLEQ 48 L +AEK A+ IA L + K + N ++T GHLL Sbjct: 4 LNVAEKNDAAKNIAAYLSRGTYKRREGLWLYNKIFEFNSYLWNKNCHMIMTSVSGHLLN- 62 Query: 49 AQPDAYDSRYARWNLADLPIVPEKWQLQP--RPSVTKQLNVIKRFLHEASEIVHAGDPDR 106 + Y +W + + ++ + S K +++ + + + ++ D DR Sbjct: 63 ---CEFVGIYRKWQSCHPLSLFDAPVVKQCSQESSIKIKKTLEKEVQKCNALIIWTDCDR 119 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + E++ + A + ++ R +++ +V R++ L + + + R+ Sbjct: 120 EGENIGFEIIQVCR-AIKPNIRIYRAKFSEITQTSVNRSLQNLCEPDKAIS--DAVDVRS 176 Query: 167 RADWLYGINMTRAYTILGRNAGY----QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFF 222 D G TR T+ R ++S G Q P LG VV R IE F + ++ Sbjct: 177 ELDLRIGAAFTRFQTLRLRKVFPTTLADMLISYGSCQFPTLGFVVERFLAIEEFKIEPYW 236 Query: 223 EVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYND 281 ++K + ++ E G+L + E ++ QP A V + Sbjct: 237 KIKVMDIRDNI------------SVEFKWERGKLFEKLPCEIFLDICLEQPNATVQKISS 284 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K S+ PLP L+ + +++ L+A+ ++ I +KLY T LI+YPR++ P+E Sbjct: 285 KPTSKWRPLPLDTIELEKQGSRKLNLNAKEIMRIAEKLY-TQGLISYPRTETNIFPKE-L 342 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 V I+ A Q +++ + R K AH I P NL NEAK Sbjct: 343 NLISLVNQQINNPAWGNFAQQLLEKGVNPR-KGKKSDQAHPPIHPIKYCD--NLNGNEAK 399 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 VY + R +L +A+ + ++E+DIA KF A + E + + E+ + Sbjct: 400 VYEFVVRHFLACLSSNAIGHQVIVEIDIAGEKFNANGLQVIEKNYLDVYIY----EKWNE 455 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 + +G E++E +T PP+ T+A L++ M G Sbjct: 456 QKIHNYREGQVFKPTSIEMIEEKTSPPQLLTEADLITLMDK-----------------HG 498 Query: 522 LGTEATRAGIIELLFKRGFL-TKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESV 577 +GT+AT A I+ + R ++ +Y+ G L M ++P + A E Sbjct: 499 IGTDATHAEHIDTIKSRQYVGLVDEKYLIPGKLGIGLVLGYDNMGFQMSKPGLRAELERD 558 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQL-------------------------IDQAKRT-PV 611 L I E++ ++ ++ + L I + + P Sbjct: 559 LKLICEQRKNAKEVLENQINKYRDLFKISMERANLIDNALADYFDEQPTKIQELENNFPS 618 Query: 612 RQFRGIVAPGSGGSADKK--KAAPRKRSAKKSPPADE 646 + P G K K K P Sbjct: 619 QDIAIFKCPKCGLDMTLKDRKQGMGKYIGCIGYPTCN 655 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 477 bits (1228), Expect = e-133, Method: Composition-based stats. Identities = 165/681 (24%), Positives = 265/681 (38%), Gaps = 82/681 (12%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTW---------CIGHLLEQAQP 51 MRL I+EK + AR IA L + K +G TW GH+L Sbjct: 1 MRLIISEKANAARKIAQFLAEGPVK-EGKHRSVPYHTFTWRGEECVSVGLKGHVLN---- 55 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 Y Y+ W D + + L+ ++ +A ++ A D DREG+L+ Sbjct: 56 PEYPEEYSNWQKVDPRELIDARILKSVSEKG-VAAAVRSLAKKADRVIIATDFDREGELI 114 Query: 112 VDEVLDYLQLAPEKRQQ-VQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADW 170 E L A V+R + L V RA + L S L + AR D Sbjct: 115 GVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSR--ELADAGEARQDIDL 172 Query: 171 LYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVT 230 ++G +TR + + G LSVGRVQ+P L L+ R+ E FV + ++EV+A + Sbjct: 173 IWGATLTRWVSRAVKRYGS-AFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQN 231 Query: 231 PADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPL 290 F A GR A + + + A+VT + + AP Sbjct: 232 GGGP-FVARH-----------ARGRFKEEAEARRALENL-SETAVVTEVRQREATRPAPA 278 Query: 291 PFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEE----HFAGRHA 346 PF+ +A AA G+S I + LY T I+YPR+D PE G A Sbjct: 279 PFNTTAFLTAAAN-IGVSPSRAARIAEDLY-TEGYISYPRTDNTVYPESLDLREVLGFLA 336 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLI 406 + + +A LL + P R + H I PT R+S L E++ K+Y L+ Sbjct: 337 EVEGVGDYAGRLLGAGRLTPTRGRR-----QTTDHPPIYPTGRASRAELREDQWKIYQLV 391 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 R++L A + + + VA + E GW + R +E LP Sbjct: 392 VRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE----LPR 447 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 +++GDE+ + E++ ++TQPP + L+ M + LGT+A Sbjct: 448 LSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLMEDLG-----------------LGTKA 490 Query: 527 TRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISE 583 TR GII+ L+ RG++ G I T+ G A+ +L + +MTA E + ISE Sbjct: 491 TRPGIIQNLYDRGYIH--GDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISE 548 Query: 584 KQCRYQDFMQPLVGTLYQLIDQAKRTPVR-----------QFRGIVAPGSG--GSADKKK 630 + ++ L ++ D + + + P G + + Sbjct: 549 GRVSKDSVVEESRELLRRVYDHLESSEEKFADIVWNGIRGDETLGPCPNCGRNLVVRRNR 608 Query: 631 AAPRKRSAKKSPPADEVGSGA 651 ++ + + P Sbjct: 609 RNRKRFAGCEGYPECRTTFPL 629 >UniRef50_B2TNL7 DNA topoisomerase n=5 Tax=Firmicutes RepID=B2TNL7_CLOBB Length = 718 Score = 477 bits (1228), Expect = e-133, Method: Composition-based stats. Identities = 178/681 (26%), Positives = 308/681 (45%), Gaps = 63/681 (9%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 ++ IAEKPS+A+ IAD L RK DG+ + G +TW GHLL+ YD W Sbjct: 3 KVIIAEKPSVAKNIADALNIKTRK-DGYFK-GEEYYITWAFGHLLQLYDAKDYDENMKGW 60 Query: 62 NLADLPIVPEKWQLQPR----------PSVTKQLNVIKRFLH--EASEIVHAGDPDREGQ 109 + P +PE +Q + + KQ+N+IK + + ++ A D DREGQ Sbjct: 61 RMEKFPFIPESFQYKVKCDNIDRTVEDKGAAKQINIIKSLIEQEDVDGVISATDFDREGQ 120 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ DE+ +YL ++ + R L+N+ P V++ + L+ N E L + + R D Sbjct: 121 VIADELFNYL----NIQKPIYRLLLNEWTPDEVKKGMGSLKENKEMQFLQDAGIGRQWTD 176 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 W+ GIN+T T+ + +++GRV P L ++ RD+EIENF A ++++ + Sbjct: 177 WIIGINLTSVSTLKYKFE-ENKTINIGRVLLPTLKIIYDRDKEIENFEATTYYKLTSTFK 235 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAP 289 ++E F ++ Y+ E + + + +++V + G A + +++ + P Sbjct: 236 NSSNEEFDGLY--------YEKESEKFEDKSVLDNLVKLLDGTNATIIDKQTEKKKDYPP 287 Query: 290 LPFSLSALQ-IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVM 348 F+LS LQ +K G ++ VL + Q LYE K TYPR+ L E V+ Sbjct: 288 YLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYE-KKYTTYPRTASVVLEESLEDRARKVL 346 Query: 349 NAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIAR 408 N + + P + + R +D+ KV++H AI PT L+++E VYN I Sbjct: 347 NTLKIGLPY---EKDIKFIKTKRVFDNSKVESHSAITPTYIKP-NGLSKDEEIVYNAIKN 402 Query: 409 QYLMQFCPDAVFRKCVIELDIAKG----KFVAKARFLAEAGWRTLLGSKERDEENDGTPL 464 +++MQF P A F + I L + +F++K + GWR + +D T L Sbjct: 403 RFIMQFMPIAEFEETKIRLKPSNEEIQGEFISKGKVQLVEGWRVVEKIDTKD-----TIL 457 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT----D 520 P+V +++ +V + +PP+H T+ TLL M + ++ K+ + + + Sbjct: 458 PMVNVDEKVDIVSNKVNKVTKKPPKHHTEKTLLRVMETCGKGIEGKEDSEEMMQSILNGF 517 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLT 579 +GT ATRA I+ L G++ KG+ + T G + P + + T ES L+ Sbjct: 518 SIGTPATRAETIKKLKDIGYIGTKGKSLICTQLGINIVEIFPVQELLDLEYTGRLESTLS 577 Query: 580 QISEKQCRYQDFMQPLVGTLYQLIDQAKR-----------TPVRQFRGIVAPGSGGSADK 628 I + + + DFM + +D+ K+ P P G S Sbjct: 578 DIEKGKFKKSDFMSLIYDFTNNAVDKIKKDTSALSKFKVELPEGAEEIGKCPVCGNSVI- 636 Query: 629 KKAAPRKRSAKKSPP-ADEVG 648 K + + Sbjct: 637 ---ENEKNFGCTNWKNGCKYT 654 >UniRef50_B5EWF7 Topoisomerase n=1 Tax=Salmonella enterica subsp. enterica serovar Agona str. SL483 RepID=B5EWF7_SALA4 Length = 726 Score = 477 bits (1227), Expect = e-133, Method: Composition-based stats. Identities = 197/678 (29%), Positives = 314/678 (46%), Gaps = 47/678 (6%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M L IAEKP LA IA +K G+ EC N VVTWC GH+L PD + Y Sbjct: 1 MILTIAEKPELAEIIAKAFGGEVKKS-GYWECANNNVVTWCYGHMLVLTPPDKVNPSYKT 59 Query: 61 WNLADLPIVPEKWQLQPR----PSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 W ++DLP+ + + + V +Q +I L ++S +++AGDPD EG+LLV E+L Sbjct: 60 WVMSDLPMDLTEVSHEVKTTENGYVERQYKIITDLLRKSSSVINAGDPDDEGELLVREIL 119 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS--EFVPLCVSALARARADWLYGI 174 + VQR L+NDLN A ++A+ +L+ + +F+ L + ALARA+ D +YG+ Sbjct: 120 ----WKENYNKPVQRLLLNDLNVNAAKKALSKLQDGNSEKFMRLALKALARAKGDQIYGL 175 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 NMTR YT+L R G G L+ GRVQTP+LGL+V+R E+ +N V ++++V + Sbjct: 176 NMTRYYTLLNRQHGGNGKLTCGRVQTPMLGLIVKRYEDFKNHVKSNYYDVYSSHNILKSV 235 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 I A +G++L +AE++ + +P+ V + + PLPF L Sbjct: 236 YLKLIADDKFA------TDGKILSPEVAENIKSACVMKPSTVVVAKVEDKHTPPPLPFDL 289 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETH-KLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 LQ K + ++I QKL I+Y RSDCRYL + + A + A+ Sbjct: 290 LGLQAYMLKD-NIDPTETMEITQKLRSKEIAAISYNRSDCRYLTSDQYDEAPATLEALKK 348 Query: 354 HAPDLLPQPVVDP-----DIRNRCWDDKKVDAHHAIIPTARSSAIN-LTENEAKVYNLIA 407 + + + V++ + ++D V AH IIP+A ++ LT E KVY I Sbjct: 349 YISGGILESVINNNGFDIKRKGIAFNDDNVSAHTGIIPSAEPRNLDKLTSKEKKVYEAIV 408 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTP---- 463 +YL+QF D ++ + ++ +F A L GW L D+ + Sbjct: 409 LRYLLQFLDDKKYQSAKVIIECEGYRFGGSATKLVSPGWTALEAEDSDDDSAEENTDSAF 468 Query: 464 --LPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD- 520 + + D +C V +++T+P +T T L + ++R+V D +K++L + D Sbjct: 469 DAISAMKVDDVGVCNDVRVDKKETKPLPVYTMKTFLEDLKRVSRYVTDPHIKQLLLSKDK 528 Query: 521 -------GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAH 573 G+GT ATRA II L G+ T + + T+ G +LP + PDMTA Sbjct: 529 GKKGERGGIGTPATRATIISNLESTGYFTVQNGKLIPTEKGIGFIKNLPVAVSAPDMTAL 588 Query: 574 WESVLTQISEKQCRYQDFMQPLVGTLYQLID--------QAKRTPVRQFRGIVAPGSGGS 625 W I E DF+ + T+ +L++ A + Sbjct: 589 WHEQQMMIMEGDLELGDFIININNTVKELMNPELSQGIVSAAQNFADNKPVGKCFCCSSE 648 Query: 626 ADKKKAAPRKRSAKKSPP 643 ++ Sbjct: 649 MKLTPKVYACQNEGCGFK 666 >UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepID=B6KEM8_TOXGO Length = 677 Score = 476 bits (1226), Expect = e-133, Method: Composition-based stats. Identities = 145/670 (21%), Positives = 241/670 (35%), Gaps = 62/670 (9%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN-------------GQVVTWCIGHLLEQA 49 L +AEKPS+A+ + +L ++ + T GHL+ Sbjct: 9 LNVAEKPSVAKEASRLLSGGYQNAPTQSRFNPVHQFEFSLQNRSCTMLFTSVRGHLMSLD 68 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQ 109 AY + DL P + + + +A +V D DREG+ Sbjct: 69 FASAYQ-NWNTIPPEDLYGAPVEKNI--SQDAGDVRKNLVDLARKAQWLVLWLDCDREGE 125 Query: 110 LLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 + EVL + A V R + + L +ERA L++ + R+ D Sbjct: 126 NIAFEVLSVCREA-NASLNVFRAVFSALTKADLERACRTLQAPDR--NQSDAVDTRSEID 182 Query: 170 WLYGINMTRAYTILGRN--AGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAH 227 G + TR T+ R+ +S G Q+P LG VV R E+ENFV + ++ ++ Sbjct: 183 LRIGASFTRFLTMRYRSRVKLPSPTISYGPCQSPTLGFVVSRFVEVENFVREAYWTIRVT 242 Query: 228 IVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI-SGQPAIVTSYNDKRESE 286 I P DE+ + E RL + + A VT ++ Sbjct: 243 ISKPDDEKGA---NAPPLSIDFTWERQRLFDQLAVLVLYEMCLENPEATVTDVRGTERTK 299 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P+P L A+++ +S+ + I + LY+ +I+YPR++ Sbjct: 300 QRPVPLCTVELHKMASRKLRMSSARCMSIAESLYQ-RGIISYPRTETEVFSPTM-DLLSL 357 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLI 406 + I A Q +VD D + AH I P L E E K+Y + Sbjct: 358 IRVHIGSTAWGTYAQKLVDGDFLWPSDGARDDKAHPPIHPLKLMQRSELEEEEWKLYEFV 417 Query: 407 ARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPV 466 R +L DA + +E+DIA F A + E W + E+ G LP Sbjct: 418 TRHFLACCSEDAFGFETRVEIDIAGEGFYATGLTVLERRWLDVYPY----EQWSGNRLPR 473 Query: 467 VAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEA 526 + ++ + ERQT+PP T+A L+ M +G+GT+A Sbjct: 474 FLVNERVMPSSILMSERQTEPPPLLTEADLIDLMDK-----------------NGIGTDA 516 Query: 527 TRAGIIELLFKRGFLTKKGR-YIHSTDAGKALFHSLPE-------MATRPDMTAHWESVL 578 T I + R + K TD G AL+ + PD+ A E+ + Sbjct: 517 TMHDHIRTIQDRHYCYKNENMQFVPTDLGVALYQGFKRLAEVSGVDLSLPDLRARMEADM 576 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAK------RTPVRQFRGIVAPGSGGSADKKKAA 632 ++ Q+ + V + ++ K T +R G + G A Sbjct: 577 ALVARGAKTKQEVLDLHVSEMKRVFLLLKSHAAHMDTEMRNRLGGLEDSVGRDGVTLVAN 636 Query: 633 PRKRSAKKSP 642 + ++P Sbjct: 637 FSECGKCRAP 646 >UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1_TREPA Length = 731 Score = 476 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 135/670 (20%), Positives = 241/670 (35%), Gaps = 86/670 (12%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 L I E P+ A+ I L VV +GH+++ + + Sbjct: 18 HLVIVESPAKAQTIEKYLG-------------TQYVVRASMGHVIDLPKSRLAIDIEHDF 64 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 PE ++ R L ++ ++ ++ A D DREG+ + + +Q Sbjct: 65 Q-------PEYITVRGRAQC---LKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQA 114 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + ++R + N++ P A+ AI + AR D L G ++ Sbjct: 115 YCDT--PIKRIVFNEITPHAIRAAIGHPVPID--TAKVNAQKARRVLDRLVGYHLCPLLW 170 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 +N LS GRVQ+ L L+ R+ E++ FV ++++ V+ F+A+ Sbjct: 171 HKVKNG-----LSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDKK-SFSALLI 224 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA 301 Q ++ + A + S A V+ ++ PF+ S LQ A Sbjct: 225 ------LIQGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCA 278 Query: 302 AKRFGLSAQNVLDICQKLYET-------HKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 A R G +++ + + Q+LYE LITY R+D + E A + + H Sbjct: 279 ANRLGFTSRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWI---ATH 335 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIARQ 409 D LP K DAH AI PT + LT ++ ++Y LI + Sbjct: 336 FSDALP-----GTPNRYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWER 390 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAK 469 ++ DA R E+ F A + E G+ +L ++ LP + Sbjct: 391 FVASQMTDARVRSLTFEITAGPAVFSATETQVIEQGFYRVLKMLSP-KDLSKAVLPPTKE 449 Query: 470 GDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRA 529 G+ + + V+ TQ P +TDA+++ + G+G +T A Sbjct: 450 GEVVALHNVQSVQHFTQGPVRYTDASIVKMLEE-----------------KGIGRPSTYA 492 Query: 530 GIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQISEKQC 586 I +L R ++T+ + + T GK + L TA ES L ++ E + Sbjct: 493 PTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKI 552 Query: 587 RYQDFMQPLVGTLYQLIDQAKRTPVR------QFRGIVAPGSGGSADKKKAAPRKRSAKK 640 ++ + + + + + +V G + KK A Sbjct: 553 KWNCVIADFYPAFSEKVSTVMKDLNSMRGVFDEKTDVVCSQCGDTMVKKLGRFGFFLACG 612 Query: 641 SPPADEVGSG 650 P Sbjct: 613 KFPECRNTQP 622 >UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_9FLAO Length = 820 Score = 476 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 131/677 (19%), Positives = 229/677 (33%), Gaps = 113/677 (16%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L K + VT GH+ + + ++ Sbjct: 5 LVIVESPAKAKTIEKFLGKDFK-------------VTSSFGHIADLPSRELGVDVDKDFS 51 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + +K +A I A D DREG+ + + + L+L Sbjct: 52 P----------KYVVDKEKKALVKKLKELASKAETIWLASDEDREGEAISWHLAETLKLD 101 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 + + +R + N + A+++AI+ R + L + AR D L G ++ Sbjct: 102 AD---KTRRIVFNSITKSAIQKAIENPRKIN--YDLVNAQQARRILDRLVGYELSPVLWK 156 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 + LS GRVQ+ + L+V R+ IE F + F+V A T A Sbjct: 157 KIKPG-----LSAGRVQSVAVRLIVERERAIEEFEPQSSFKVAAEFRTENGATLPAKLNE 211 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 S A+ + ++ V S + K +S PF+ S LQ EA+ Sbjct: 212 S------------FDTETEAQEFLAGLANASFAVDSLDTKPAKKSPAAPFTTSTLQQEAS 259 Query: 303 KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQP 362 ++ S + + Q+LYE LITY R+D L E A + + Sbjct: 260 RKLYFSVSRTMQVAQRLYEA-GLITYMRTDSVSLSGEAIAAAKE--EIVGNYGEKY---- 312 Query: 363 VVDPDIRNRCWDDKKVDAHHAIIPTAR-SSAINLTENEAKVYNLIARQYLMQFCPDAVFR 421 + + +AH AI PT N+ ++A++Y LI + L DA Sbjct: 313 --SKVRKFQSKSKGAQEAHEAIRPTDMGLQRPNVERDQARLYELIRMRTLASQMSDAQLE 370 Query: 422 KCVIEL--DIAKGKFVAKARFLAEAGWRTLL--GSKERDEENDGTPLPVVAKGDELLCEK 477 + +++ D F A + G+ + G E D E LP + + L Sbjct: 371 RTQVKIRNDRDDRLFSANGEVIKFDGFLKVYLEGKDEEDAEEQDGMLPAMQVDEALTNNY 430 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 +R T+PP +T+A+L+ + + +G +T A I + Sbjct: 431 ITATQRFTRPPYRYTEASLVKKLEELG-----------------IGRPSTYAPTISTIQN 473 Query: 538 RGFLTK-------------------------------KGRYIHSTDAGKALFHSLPEMAT 566 RG++ K + TD G + L Sbjct: 474 RGYVEKGTVDGTEREYLQLTLEGGGVKRKELSETVGSDKGKLVPTDIGMIVNDFLVSHFA 533 Query: 567 ---RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVR---QFRGIVAP 620 + TA E I+ + +QD ++ + + + R + P Sbjct: 534 NILDYNFTAKVEKDFDDIATGEEDWQDVLRDFYKDFHPNVLDVEENADRASGERVLGTDP 593 Query: 621 GSGGSADKKKAAPRKRS 637 +G + Sbjct: 594 ETGRQVAVRLGRFGPMV 610 >UniRef50_B6A9W0 DNA topoisomerase n=2 Tax=Eimeriorina RepID=B6A9W0_9CRYT Length = 843 Score = 476 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 136/698 (19%), Positives = 246/698 (35%), Gaps = 89/698 (12%) Query: 3 LFIAEKPSLARAIA----------DVLPKPHRK----GDGFIECGN--GQVVTWCIGHLL 46 L IAEK S+A+ IA + L + + G+ +VT GH+ Sbjct: 56 LCIAEKHSVAKEIAWCLCPQNQNPNYLNSKSKTNPVLSFPYYFEGSKCNMIVTSVRGHIK 115 Query: 47 EQAQPDAYDSRYARWNLADLPIVPE---KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGD 103 + +D R++ W D ++ +K + AS ++ D Sbjct: 116 QL----KFDPRFSSWETVDPIVLLNLSTPLIKVVSEDCNDIAQNLKHYSKLASTLILWLD 171 Query: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 DREG+ + EV+ L + ++ R + L +E A++ L + + + + Sbjct: 172 CDREGENIAFEVISVC-LDANPKLKILRARFSALTKSDIEGAMNNLVAPNR--AMSDAVE 228 Query: 164 ARARADWLYGINMTRAYTILGRNAGY--QGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF 221 AR D G + TR T+ + + LS G Q P LG VV R +I +F ++ F Sbjct: 229 ARQEIDLRIGSSFTRFLTLRYQKLFPIPESTLSYGPCQFPTLGFVVDRYRKIVSFKSEPF 288 Query: 222 FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYN 280 +++ + +++ + + R+ A + P A V S + Sbjct: 289 WQISVTLSFHSEDG-----SLKDKLIKFDWIRDRIFDHLAALVIYEFCLEDPIATVVSVH 343 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K+ PLP + + A+ + + ++I + LY+ I+YPR++ PE Sbjct: 344 GKQVRNYKPLPMNTVEMTKIASIKLNIPPITTMNIAENLYQ-KGYISYPRTETNSFPESM 402 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTE-NE 399 + + N + ++H I P T E Sbjct: 403 DLKVIIREQINHQTWGRYASLLISNDKYCNPRCGNSSDESHPPIHPVKCLDQNEATSAEE 462 Query: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 K+Y LI R +L DA+ ++ V+ LDIA +F AK + E W + E Sbjct: 463 WKLYELITRHFLAVCSDDAIGQESVVILDIAGEQFKAKGLVVLEENWLDIYKPY---ERW 519 Query: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 G LP +GD+L + + +T+PP T+A L+ M Sbjct: 520 CGNVLPEFNQGDKLTPYSIFLSQSKTEPPHLITEAELIDLMDK----------------- 562 Query: 520 DGLGTEATRAGIIELLFKRGFLTKKGR-YIHSTDAGKAL--------------------- 557 +G+GT+AT IE + R ++ K R + T G AL Sbjct: 563 NGIGTDATMHEHIEKIQTRQYVIKNPRSQLIPTSLGYALALGFEEISKEANKIEQRDGLL 622 Query: 558 ---------FHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKR 608 + RP++ + E + +IS + ++ ++ + Sbjct: 623 LASDSSRNSICKFDKNLIRPNLRSAMEFSMKEISGGILNRSTVVAEILDSMKYIYQTMVH 682 Query: 609 TP--VRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPA 644 + + + P K R +S Sbjct: 683 SIRFLDNSFKLYFPRWDSDLVFKNGTIRIKSFSICGGC 720 >UniRef50_C2UN45 DNA topoisomerase III n=5 Tax=Bacillus cereus group RepID=C2UN45_BACCE Length = 756 Score = 475 bits (1223), Expect = e-132, Method: Composition-based stats. Identities = 172/696 (24%), Positives = 297/696 (42%), Gaps = 74/696 (10%) Query: 6 AEKPSLARAIADVLPKPHRKGDGFIE------CGNGQVVTWCIGHLLEQAQPDAYDSRYA 59 AEKP +A+ I PK ++K D + E +G V +C+GHL + Sbjct: 2 AEKPDVAKKIVAAFPK-YKKHDLYYEIMPCNEFPDGAYVAYCMGHL--LTFDEEKMGTNT 58 Query: 60 RWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLD 117 W+L+ LPI+P+ + +P K + IK+ + + + ++ D REG + E++ Sbjct: 59 PWSLSGLPIMPKSYIYKPIKGREKHVRTIKKLANDPKVTMFINCCDSAREGMKIFTEIIK 118 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 Y+ + + I+ L P ++++ + L L SA ARA AD+L GIN++ Sbjct: 119 YV---TNRNLPTKCLWISSLTPASIKKGMQELVPYKSKENLYHSAYARAIADFLVGINLS 175 Query: 178 RAYTILGRNAG-------------YQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEV 224 R+ ++ ++ + V S+GR Q+P L LV R ++IE V + F+ + Sbjct: 176 RSVSLRMQSEFASRNAENGDLNGLKREVFSIGRCQSPTLRLVYDRIKQIEAHVPEPFWTL 235 Query: 225 KAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRE 284 E +T W ++++ R E + R+ +PAI+ +R+ Sbjct: 236 SGIFEIDGKE-YTGRW--------FKEDNNRFDSEEEIEDLSIRLVEEPAIIKEIKKERK 286 Query: 285 SESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGR 344 + P F L+ LQ A K F + + L + LY L++YPR+D Y+ Sbjct: 287 AFKPPQFFDLTRLQSTANKLFKMDPKETLHHAESLYLA-GLLSYPRADNPYITAAEAPIL 345 Query: 345 HAVMNAIS--VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSA-INLTENEAK 401 V+ + LP P+ D+ +R ++KKV HH II L E Sbjct: 346 STVLEKLKYTESYSKYLPAPIRSTDLSSRYINEKKVSDHHGIIVLDVPKDFSKLNPGEKA 405 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAK-GKFVAKARFLAEAGWRTLLGSKERDEEND 460 +Y+L+ ++ + DA++ I + + F+ K + GW+ L ++ EE D Sbjct: 406 IYDLVVKRVIAAHHEDALYDFTSIITVVDETETFLTKGKQEVSLGWKMLYQKEQVSEEKD 465 Query: 461 GT--------PLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDL 512 LP V +GD E+ + T+ P + T TL+ M +++K++ Sbjct: 466 DQEEENEEVAQLPDVKEGDTGTIVDTEISKGMTKAPPYLTPGTLVELMENCGSLMEEKEM 525 Query: 513 KKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL-PEMAT-RPDM 570 +KIL+ T G+GT ATR GII L+ RG+L K + + G+ L +L +M P++ Sbjct: 526 QKILKKTSGIGTVATRDGIIHTLYDRGYLVNKNNKVLLLEKGRMLMDALGDKMIVCSPEL 585 Query: 571 TAHWESVLTQISEKQCRYQDFMQPLVGTLYQL-------------------IDQAKRTPV 611 TA WE+VL IS+ + Y+ F+ + +L I++A R Sbjct: 586 TAKWENVLEAISDGRIDYKQFIGKAEKLVVKLLNDIEQISKSWNLDSSIKKIEEANRKEE 645 Query: 612 RQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 + G KK Sbjct: 646 EKKLLGSCLKCGSQVVLKKG----FYGCTGYSTTGC 677 >UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N8U4_9BACT Length = 841 Score = 475 bits (1222), Expect = e-132, Method: Composition-based stats. Identities = 130/632 (20%), Positives = 226/632 (35%), Gaps = 86/632 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ AR I +L K + +GH+ + + D + Sbjct: 3 KLLIVESPTKARTIGKMLGK-------------DYDIFASMGHIRDLPERDLGVDIANHF 49 Query: 62 NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQL 121 Q + +K +A EI A DPDREG+ + + + L Sbjct: 50 AP----------QYVDTARSKSVVKELKSAAKKADEIYLAPDPDREGEAIAWHLAEVLNK 99 Query: 122 APEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYT 181 + + R +++ A+ERA+ + + L + AR D + G ++ Sbjct: 100 S--TKAPFYRVTFHEITRSAIERAMQEKGEIN--LNLVDAQQARRVLDRIVGYQVSPLLW 155 Query: 182 ILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQ 241 S GRVQ+ L LVV R+ I FV ++++ T + E FT+ Sbjct: 156 SRIEKGS-----SAGRVQSAALRLVVERERAINAFVPEEYWVFSVVFRTESGEEFTSRLF 210 Query: 242 PSEACEPYQDEEGRLLHRPLAEHVVNRISGQPA-IVTSYNDKRESESAPLPFSLSALQIE 300 ++ ++ + AE ++ I G A V S A PF+ S LQ Sbjct: 211 KING------KDFKVPNAEAAEQLIRAIQGGSAPAVASVTTAERKRYAQAPFTTSTLQQA 264 Query: 301 AAKRFGLSAQNVLDICQKLYE--------THKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 A SA N + Q+LYE LITY R+D + E + Sbjct: 265 ANVSLHYSATNTMRYAQQLYEGMDIGEGGAVGLITYMRTDSVTIAREAQQAAAEFIRRT- 323 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIA 407 + +P +AH AI PT L + K+Y LI Sbjct: 324 -YGDAYVPAK-----FNYYKNKAAAQEAHEAIRPTDVRRTPEQMAAYLDPQQLKLYTLIW 377 Query: 408 RQYLMQFCPDAVFRKCVIEL-----DIAKGKFVAKARFLAEAGWRTLLGS--KERDEEND 460 R+++ AV +++ D F A G + K +DE + Sbjct: 378 RRFVASQMTPAVVNLTTVDVGVDGSDGNGYTFRTTATVPVFPGHSKVYEDVAKRKDETQE 437 Query: 461 GTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD 520 L + + D L K + ++ T+PP +T+A+L+ + + Sbjct: 438 AAVLGSLRERDPLELRKFDKEQKFTEPPPRYTEASLIKELEE-----------------N 480 Query: 521 GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESV 577 G+G +T A I+ + R ++ ++ + ++ G ++ L E TA E Sbjct: 481 GIGRPSTYATILRTIQDRNYVNREQGKLIPSELGFSVNDFLVERLPALFDIGFTAQMEKE 540 Query: 578 LTQISEKQCRYQDFMQPLVGTLYQLIDQAKRT 609 L +I E + + M+ ++ AK + Sbjct: 541 LDEIEEGKVGWTQMMEDFYSKFAPWVEDAKNS 572 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 474 bits (1221), Expect = e-132, Method: Composition-based stats. Identities = 152/652 (23%), Positives = 272/652 (41%), Gaps = 76/652 (11%) Query: 2 RLFIAEKPSLARAIADVLPKP-----HRKGDGFIECGNG---QVVTWCIGHLLEQAQPDA 53 L IAEK + A+ IA +L + + + G V GH+L Sbjct: 20 ILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHM----D 75 Query: 54 YDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVD 113 Y ++ RW+L DL + ++ ++ N+++ +A ++ A D DREG+L+ Sbjct: 76 YPDKFKRWSLGDLQRLVDEEPIKIIKEKG-IANILRTLAKDADMLIIATDYDREGELIGV 134 Query: 114 EVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYG 173 E L + V+R + L + +E A L + L +A R + D +G Sbjct: 135 ESLSIT----NFKGPVKRAKFSALTEREIENAFSNLVDVN--YNLASAAETRQKIDLAWG 188 Query: 174 INMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAD 233 ++TR ++ G + LSVGRVQ+P L L+V+R++EIENFV ++ +K Sbjct: 189 ASLTRFISLASSRRG-KDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFF--KR 245 Query: 234 ERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPF 292 F+ + V ++ + A V + + P+PF Sbjct: 246 RNFSGMHIS-----------NPFWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPF 294 Query: 293 SLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS 352 + + EA K G SA + + ++LY I+YPR+D P+ ++++ ++ Sbjct: 295 NTTEFLSEATK-LGFSAAKAMRLAEELY-MGGYISYPRTDNTVYPKT--LSINSILKSLE 350 Query: 353 VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLM 412 + R K+ H I+PT + NL ++ K+Y L+ R+++ Sbjct: 351 KSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGA---NLEGDKGKIYELVVRRFMA 407 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 D +R+ ++L + F AK + L GW +EE +P++ GDE Sbjct: 408 TLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEK----IPILRIGDE 463 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +K E+ ++T+PP +T ++L+ M + LGT++TRA II Sbjct: 464 VKVKKIEIERKETRPPARYTQSSLIREMEKL-----------------NLGTKSTRAEII 506 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQ 589 + LF+RG++ +G I T GKAL SL +PDMTA E + +I + + Sbjct: 507 QKLFERGYV--RGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPE 564 Query: 590 DFMQPLVGTLYQLIDQAKRTPVRQFRGIV---------APGSGGSADKKKAA 632 ++ L +++ + I P G ++ Sbjct: 565 FVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKR 616 >UniRef50_C8WG68 DNA topoisomerase type IA central domain protein n=9 Tax=Coriobacteriaceae RepID=C8WG68_EGGLE Length = 849 Score = 474 bits (1219), Expect = e-132, Method: Composition-based stats. Identities = 158/716 (22%), Positives = 258/716 (36%), Gaps = 108/716 (15%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIEC--------GNGQVVTWCIGHLL--EQAQ 50 M+L + EK A+ IAD+L K D G V GH+L + A Sbjct: 1 MKLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAP 60 Query: 51 PDAYDSR--------------------------------------YARWNLADLPIVPEK 72 Y R W + LP + Sbjct: 61 TMVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYL-VY 119 Query: 73 WQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRC 132 + P + + +K +A ++ A D DREG+L+ + L + V R Sbjct: 120 APINKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCI-QEVNPTAPVSRA 178 Query: 133 LINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGV 192 + + + A D L V L + +R D ++G +TR T+ + AGY V Sbjct: 179 RYSAFTKEEITHAFDNLVELD--VNLASAGASRQDIDLIWGAVLTRYLTL-VKFAGYGNV 235 Query: 193 LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDE 252 S GRVQTP L LVV R+ E FV +D++ ++ + F A Sbjct: 236 RSSGRVQTPTLALVVARERERLAFVPEDYWVIRGAF-GADPDSFEAPHAT---------- 284 Query: 253 EGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQN 311 R A+ V+ + G A V S K+ + P PF+ ++L A+ GLS Sbjct: 285 -ARFKAEAEAQAVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAE-GLSPAR 342 Query: 312 VLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNR 371 + I + LY I+YPR D P V A + ++ Sbjct: 343 TMRIAESLY-MDGYISYPRVDNTVYPSS-LDLADTVKAISGNPAYAPYCKELLAKGKLTA 400 Query: 372 CWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAK 431 K+ H I PTA+++ +L + K+YNLIAR++L AV + LD+ Sbjct: 401 TRGKKETTDHPPIYPTAKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNA 460 Query: 432 GKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHF 491 FVAK L + G+R + + +E LP +++G+ + ++QT+PP + Sbjct: 461 EPFVAKGDVLVKPGYRAIYPYGLKKDE----QLPALSEGETVAFNGAVCTKKQTEPPARY 516 Query: 492 TDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHST 551 + L+ M + LGT++TR IIE L+ + I + Sbjct: 517 SQGKLIQEMEKLG-----------------LGTKSTRHAIIERLYAVKYCMND--PIEPS 557 Query: 552 DAGKALFHSLPE---MATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLI----- 603 G A+ +L + T P+MTA E + I+E + + L + + Sbjct: 558 QLGMAVCDALDKFAPHITHPEMTAELEEEMDNIAEGRTTKAQVVDTSRNLLSEQLASLLP 617 Query: 604 --DQAKRTPVRQFRG----IVAPGSGGSADKKKAAPRK--RSAKKSPPADEVGSGA 651 ++ K P G + + + P +V Sbjct: 618 HSEEVKEALADAVAADAYVGPCPKCGKDLQLRASQKTRSMFIGCAGWPDCDVTYPL 673 >UniRef50_C2BD67 DNA topoisomerase n=1 Tax=Anaerococcus lactolyticus ATCC 51172 RepID=C2BD67_9FIRM Length = 683 Score = 473 bits (1218), Expect = e-132, Method: Composition-based stats. Identities = 174/657 (26%), Positives = 288/657 (43%), Gaps = 52/657 (7%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M+L IAEKPS+A++IA+VL +++ DG+IE G +VTW GHL+ P++Y+ Sbjct: 5 MKLIIAEKPSVAKSIANVLG-CNQQQDGYIE-GRSCIVTWTGGHLVTLDDPESYNPSCNH 62 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFL--HEASEIVHAGDPDREGQLLVDEVLDY 118 WN ADLPI+P ++ + S + Q V+K + +V A D REG+L+ V D Sbjct: 63 WNKADLPILPRPFKTKLISSKSHQYKVVKNLINDKRIESVVCATDAGREGELIFRLVYDK 122 Query: 119 LQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTR 178 + ++ R I + A+ ++ + + L SA AR ADWL GIN+TR Sbjct: 123 IG----TKKTFTRMWIQSMEDPALLDEFNKAKDGHAYDNLSESAKARQEADWLVGINLTR 178 Query: 179 AYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTA 238 +I +GRVQTP L L+ R EE ENF + + ++A I Sbjct: 179 LVSIENNKKFT-----IGRVQTPTLNLINARCEEKENFKPQKYNTIQADISLDG------ 227 Query: 239 IWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQ 298 + E R+ + + + + + ++ AP + L+ LQ Sbjct: 228 --------KVITFETERIETQESNCKMSSM--SSELEIEEVISEEKTTKAPKLYDLTNLQ 277 Query: 299 IEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDL 358 A K+FGLSA+ LDI Q LYE K I+YPR+D Y+ + ++ + Sbjct: 278 RAANKKFGLSAKQTLDIAQSLYEA-KYISYPRTDSEYITSDMVESVRQLIGSHVDSD--- 333 Query: 359 LPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINLTENEAKVYNLIARQYLMQ 413 D + ++KKV H A++PT + NL +N +Y LI Q L Sbjct: 334 ------MFDNVEKIANNKKVSDHTALLPTIYSIDKKDEINNLDKNHINIYTLIYMQLLKA 387 Query: 414 FCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDEL 473 + + + I+ + + G++ L + + L + +G Sbjct: 388 VSKNYRYMQTKIKAISGDIDLYTVGKVDIDQGFKKL--ESKDNAAKSEKDLSGLEEGMSY 445 Query: 474 LCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIE 533 ++++ T+PP ++ D +LL AM + +K L+ GLGT ATRA IIE Sbjct: 446 PITDTRLMDKTTKPPAYYNDDSLLKAMKTAGSGLYEKGLE---IERTGLGTTATRADIIE 502 Query: 534 LLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQ 593 L K G++ + + I T+ GK L PE ++T +WE+ L +ISE + F+ Sbjct: 503 GLIKNGYIERSKKDIVITELGKQLLSVAPEKLKEVELTVNWENELAKISEGEKDKNSFIL 562 Query: 594 PLVGTLYQLIDQA---KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEV 647 + L +++ + V + P G+ + ++K Sbjct: 563 KIENYLKEIVKSYEGDESMKVEETIIGTCPYCQGNVYINDRSINCENSKHGKNKGNC 619 >UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular organisms RepID=A4RYV6_OSTLU Length = 840 Score = 473 bits (1217), Expect = e-131, Method: Composition-based stats. Identities = 136/701 (19%), Positives = 240/701 (34%), Gaps = 106/701 (15%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L I E P+ A+ I L + V GH+ + + Sbjct: 70 LMIVESPAKAKTIEKYLGANAK-------------VLASYGHVRDLVNKQGSVRPEESFA 116 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 + + I L + ++ A DPDREG+ + +L+ L+ Sbjct: 117 M----------TWTSTSRQKAAMRDITEALKKTDVLLLATDPDREGEAISWHLLEVLREK 166 Query: 123 P--EKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 V+R ++ AV A+ R + VP+ + +AR D+L+G ++ Sbjct: 167 KLLRDDLDVKRVTFGEITKTAVLDAVGSPRDIN--VPMVDAYMARRALDYLFGFTLS--- 221 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 +L R LS GRVQ+ L LV R+EE+E FV++ ++ VKA + + F A Sbjct: 222 GLLWRKLPSSVSLSAGRVQSVALRLVCEREEEVEAFVSEPYWTVKASLSSKDGSTFDAAL 281 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISG-QPAIVTSYNDKRESESAPLPFSLSALQI 299 + + + + AE R+ V ++ PF+ S +Q Sbjct: 282 THVDGAKLG---KFTIASNDEAEAYAKRVRECDTLRVVEVKHSEAKRTSGPPFTTSTMQQ 338 Query: 300 EAAKRFGLSAQNVLDICQKLYE----THKLITYPRSDCRYLPEEHFAGRHAVMNAISVHA 355 EA K+ G A + Q+LYE LITY R+D Y+ + Sbjct: 339 EANKQLGFGASRTMSAAQRLYEGAGTGEGLITYMRTDGTYVAPHAIESLRTTAGEL--FG 396 Query: 356 PDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA-------RSSAINLTENEAKVYNLIAR 408 + +P+ + + +AH AI PT + I +EA++Y LI Sbjct: 397 DEYVPESPRYFKKKQK----NAQEAHEAIRPTKAGRLPAQVARQIGPGSDEARLYALIWA 452 Query: 409 QYLMQFCPDAVFRKCVIELDI--AKGKFVAKARFLAEAGWRTLLGSKERDE--ENDGTPL 464 + + A+ + E+ K A L G+ + + +D L Sbjct: 453 RTMASQMSPALTDRIAAEIASAENDLKLKANGHRLKFPGFLAAYRTSRPEAAPPSDDAWL 512 Query: 465 PVVAKGDELLCEK------GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRA 518 P++ +G+ L + E E +T PP +TD +++ A+ Sbjct: 513 PILGEGEGLSVKTDGESLGCEATEHKTSPPPRYTDGSIVKALEE---------------- 556 Query: 519 TDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWE 575 G+G +T A I+++L +R ++ K+G + T G+ + L TA E Sbjct: 557 -RGIGRPSTYAPILKVLAQREYVAKQGAALVPTTRGRLVSAFLTNYFETYVDYGFTADLE 615 Query: 576 SVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQF--------------------- 614 L I+ +Q +++ ++ I V + Sbjct: 616 HKLDDITSEQVQWKPLLEEWWTPFRDKISSLSELRVSEVIDALDEKLGQHLFGEATDSDD 675 Query: 615 ---RGIVAPGSG-GSADKKKAAPRKRSAKKSPPADEVGSGA 651 P G K + P Sbjct: 676 VVSEARRCPSCKIGRLGLKPSKAGGFIGCSRYPECGFTHPL 716 >UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepID=B8DVL2_BIFA0 Length = 986 Score = 473 bits (1217), Expect = e-131, Method: Composition-based stats. Identities = 130/631 (20%), Positives = 232/631 (36%), Gaps = 84/631 (13%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A+ I L +G V +GH+ + AQP + Sbjct: 6 KLVIVESPAKAKKIGGYLG-------------DGYTVLASVGHIRDLAQPSQVPADEKAK 52 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ P K ++ ++ L ASE+ A D DREG+ + ++ L Sbjct: 53 FGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAWHLVQTL 112 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + +++ P+A+ +++ R + + R D LYG ++ Sbjct: 113 K----PKVPVKRMVFHEITPEAIRASLEHTREVDN--NMVDAQETRRVLDRLYGYELS-- 164 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA------- 232 +L R G LS GRVQ+ L+V R+ E FV +++V A + P Sbjct: 165 -PVLWRKVGPG--LSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTD 221 Query: 233 -DERFTAIWQPSEACEPYQDEEGRLLH-----------RPLAEHVVNRISGQPAIVTSYN 280 + R A+ A +G L A + + ++ V S Sbjct: 222 FESRMIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVE 281 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S +Q A R G+S++ + Q LYE + ITY R+D L E Sbjct: 282 KKPYRRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYE-NGYITYMRTDSVTLSHEA 340 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPT-----ARSSAINL 395 ++ L + + +AH I P S L Sbjct: 341 IEAARESVS--KNFGSQYLSEKPKQYATKT----AGAQEAHECIRPAGSHFRDPSQLATL 394 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI-----AKGKFVAKARFLAEAGWRTLL 450 ++ K+Y LI ++ L DA + F + + G+ + Sbjct: 395 PPDQLKLYTLIWQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVT 454 Query: 451 GSK--ERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ 508 G + + + LP +A+ EL + +TQPP +T+A+L+ + Sbjct: 455 GERGGSGKKGEESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLE------- 507 Query: 509 DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA--- 565 +G +T A II + RG++ ++GR + + A+ L Sbjct: 508 ----------AKEIGRPSTYANIISTIIDRGYVYERGRALIPSWLAFAVTRLLETKFPKY 557 Query: 566 TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 TA E+ L QI+ ++++ Sbjct: 558 VDYQFTADMENGLDQIAHGNETGREWLTQFY 588 >UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepID=B3DUA2_BIFLD Length = 1028 Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats. Identities = 129/659 (19%), Positives = 225/659 (34%), Gaps = 112/659 (16%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ A I D L K G V +GH+ + AQP + Sbjct: 4 KLVIVESPTKAHKIGDYLGK-------------GYTVMASVGHIRDLAQPSQVPAADKAK 50 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ + ++ +K L A E+ A D DREG+ + ++ L Sbjct: 51 FGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIAWHLVQTL 110 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + V+R + +++ A+ +++ R + + R D LYG ++ Sbjct: 111 K----PEVPVKRMVFHEITKNAINASLNNTRDVDG--NMVDAQETRRILDRLYGYELS-- 162 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA----DER 235 +L R G LS GRVQ+ L+V R+ E F ++++ A + P Sbjct: 163 -PVLWRKVGPG--LSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAE 219 Query: 236 FTAIWQPSEACEPYQDEEGRL---------------LHRPLAEHVVNRISGQPAIVTSYN 280 F+A ++ L A V + V S Sbjct: 220 FSARMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVAEALRTADFTVMSME 279 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S LQ A R G+ A+ V+ Q LYE + ITY R+D L +E Sbjct: 280 TKPYRRRPQPPFTTSTLQQTAGNRLGMGARVVMRAAQSLYE-NGYITYMRTDSVTLSQEA 338 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARS------SAIN 394 ++ + + + +AH I P A Sbjct: 339 ITAARNAVS------YHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASK 392 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI------AKGKFVAKARFLAEAGWRT 448 L ++ ++Y LI ++ L DA + L + F A + G+ Sbjct: 393 LPGDQLRLYTLIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMK 452 Query: 449 LLGSKER----------------------------DEENDGTPLPVVAKGDELLCEKGEV 480 G + D T LP ++ G ++ E Sbjct: 453 ATGEGRKPKAAAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEP 512 Query: 481 VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGF 540 +TQPP +T+ATL+ + +G +T A II + RG+ Sbjct: 513 DGHETQPPARYTEATLVKTLE-----------------AKEIGRPSTYASIISTIMDRGY 555 Query: 541 LTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + ++GR + + ++ L TA E+ L +I+ + +D++ Sbjct: 556 VYERGRALIPSWLAFSVTKLLETNFPKLVDYQFTAEMENGLDRIAHGEESGRDWLTHFY 614 >UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=TOP1_ARCFU Length = 663 Score = 470 bits (1209), Expect = e-130, Method: Composition-based stats. Identities = 162/667 (24%), Positives = 280/667 (41%), Gaps = 74/667 (11%) Query: 3 LFIAEKPSLARAIADVLPKPHR-----KGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSR 57 L I EK + AR IA +L K + + + N V GH++E P Sbjct: 6 LIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKE---- 61 Query: 58 YARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 W L + + +L + +++K +A + A D DREG+L+ E L+ Sbjct: 62 LNNWTKTPLEKLL-QAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALE 120 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 ++ + +V R + + + + A + L +ALAR + D ++G +T Sbjct: 121 IVK-SVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVD--FNLANAALARQKIDLIWGATLT 177 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFT 237 R ++ G + LSVGRVQTP L L+V R+ EI+NF + ++E+ A F Sbjct: 178 RLISVHSGRMG-KDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEG-----FI 231 Query: 238 AIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSAL 297 A + AE + +I G+ A V + +R E+ P PF+ + Sbjct: 232 AKHPKRYG------------SKEEAEKLFAKI-GETAKVEEFTRRRMEENRPTPFNTTEF 278 Query: 298 QIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPD 357 EA+K +S ++I + LY + I+YPR+D P +++A+S P Sbjct: 279 LREASKF--MSPHKAMNIAETLY-MNGYISYPRTDNTVYPPTI--NLIEIVSALSSVFPR 333 Query: 358 LLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPD 417 Q V+ D ++ H I PT + L+++E +Y L+ R++L P Sbjct: 334 E-AQIVLSQDKITPSRGRRETKDHPPIYPTGVAKRGELSKDEWTIYELVVRRFLATLAPK 392 Query: 418 AVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEK 477 AV+ + LD KFVA R L EAGWR + + +E LP++ KGD L K Sbjct: 393 AVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAEETE----LPLLKKGDVLRILK 448 Query: 478 GEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFK 537 + E++T+PP ++ ++L+ M + LGT++TR II+ L Sbjct: 449 KRLEEKETKPPGRYSASSLIKMMEKL-----------------NLGTKSTRHEIIQKLVS 491 Query: 538 RGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCRYQDFMQP 594 R ++ G ++ ++ + L E T PDMTA E+ + I+E + R + + Sbjct: 492 RRYIH--GNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGKKREPEVVDE 549 Query: 595 LVGTLYQLI---------DQAKRTPVRQFRGIVAPGSGGSADKKKAA-PRKRSAKKSPPA 644 L Q++ + + P GG +++ ++ + P Sbjct: 550 SREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAGKRFIGCSNYPD 609 Query: 645 DEVGSGA 651 Sbjct: 610 CTFTLPL 616 >UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales RepID=TOP1_MYCLE Length = 947 Score = 469 bits (1208), Expect = e-130, Method: Composition-based stats. Identities = 125/638 (19%), Positives = 227/638 (35%), Gaps = 91/638 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDS-RYAR 60 RL I E P+ AR ++ L + +V GH+ + + A ++ Sbjct: 17 RLVIVESPTKARKLSGYLG-------------SAYIVESSRGHIRDLPRTAADVPAKFKS 63 Query: 61 WNLADLPI---VPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLD 117 A L + + P + +K L E+ A D DREG+ + ++ Sbjct: 64 EPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQ 123 Query: 118 YLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMT 177 L+ R V+R + +++ A+ A R + L + R D LYG ++ Sbjct: 124 TLK----PRVPVKRMVFHEITEHAILAAAAHPRELD--IDLVDAQETRRILDRLYGYEVS 177 Query: 178 RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV------TP 231 LS GRVQ+ ++V+R+ + F + ++++ A + T Sbjct: 178 PVLWKKVAPK-----LSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTA 232 Query: 232 ADERFTAIWQPSEACEPYQDEEG---------------RLLHRPLAEHVVNRISGQPAIV 276 F A + + +L A + + G V Sbjct: 233 QPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTV 292 Query: 277 TSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYL 336 S +K + PF S LQ EA ++ SA+ + I Q+LYE + ITY R+D L Sbjct: 293 ASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYE-NGYITYMRTDSTTL 351 Query: 337 PEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIP------TARS 390 E A ++ + + + + +AH AI P T + Sbjct: 352 SESAINAART--QARQLYGEEYVSDSPRQYTRKVK----NAQEAHEAIRPAGETFATPDA 405 Query: 391 SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK----FVAKARFLAEAGW 446 L +E ++Y L+ R+ + DA + ++ G+ F A R L G+ Sbjct: 406 VCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGF 465 Query: 447 RTLLGSKER-----DEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMT 501 + ++ LP + G L T PP +T+A+L+ A+ Sbjct: 466 LKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALE 525 Query: 502 GIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL 561 + +G +T + II+ + RG++ KKG + + A+ L Sbjct: 526 ELG-----------------IGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLL 568 Query: 562 PEMA---TRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 + D TA E L +I+ + +++ Sbjct: 569 EQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFY 606 >UniRef50_D2P3C5 DNA topoisomerase III n=1 Tax=Listeria monocytogenes 08-5578 RepID=D2P3C5_LISMO Length = 714 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 185/657 (28%), Positives = 307/657 (46%), Gaps = 42/657 (6%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIEC-----GNGQVVTWCIGHLLEQAQPDAYDS 56 + +AEKP+ A A+ + +K GF E + +T +GHL++ P YD Sbjct: 3 IVILAEKPNQALTYAEAM-HHFKKHRGFYEVQDELFADQTFITHGLGHLVDLFMPGQYDP 61 Query: 57 RYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVL 116 + +W++ +LPI PE + +PS +Q ++K+ L EA+ I+ A D DREG+L+ E+L Sbjct: 62 KLKKWDMTNLPIFPETIRYYVKPSNQEQFQIVKKLLSEATTIIIATDCDREGELIAREIL 121 Query: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINM 176 + +L+ E + +QR IN L +A+ L V A R ++DWL G+N Sbjct: 122 NQTKLSFEG-KNIQRLWINSLEKEAIREGFQSLWHAGHTYFKYVEAQTRQKSDWLIGMNF 180 Query: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERF 236 T Y++L + G +GRVQTP L +V +R++EIENF + FE+ +++ Sbjct: 181 TPLYSLLLQEYGSFSQYPIGRVQTPTLMMVYKREKEIENFKPRKMFELFYE-NKMEEQKI 239 Query: 237 TAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSA 296 A + + ++ L R + RI A V + +K E ++PL FSLS Sbjct: 240 LAKIKTHPLFDTKEEVYAFLKERNM------RIGPTEATVLNMVEKEEKHASPLLFSLSN 293 Query: 297 LQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAP 356 LQI K+F S + L QKLYE K ++YPR+DC ++ ++ F+ + A Sbjct: 294 LQILMNKKFKYSPKETLQGVQKLYE-KKWLSYPRTDCTFITQKEFSYLKMKLQEYKAFAH 352 Query: 357 DLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENEAKVYNLIARQYLM 412 + P ++PD R D+ +V+ HHAIIPT + LT E ++Y + + Sbjct: 353 IEVYTPNLEPDFRY--VDNHEVNEHHAIIPTRIIPSAAEFSKLTTLEKQIYTWVLHVTIA 410 Query: 413 QFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDE 472 F P + ++ ++L I + F AK R + GWR ++ + E+ L GD Sbjct: 411 MFAPPMLIKEIAMDLRIGELLFEAKERTPVDMGWRKIILGNNQKEKISRQSLSNFHIGDT 470 Query: 473 LLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGII 532 + +E+ +PP FT+ L+ AM + K++ G+GTEATRA ++ Sbjct: 471 IH-GFLGGIEKDKKPPSPFTEGALIHAMKNAGKKA--GQSKEMGLKVMGIGTEATRADVL 527 Query: 533 ELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM--ATRPDMTAHWESVLTQISEKQCRYQD 590 E L + +L ++ TD GK L + + DMTA E+ L I E ++ Sbjct: 528 EKLKNQDYLKLTKNKLYVTDKGKELGRVIENDPLLSNIDMTASLETALHSIGEGITTQEE 587 Query: 591 FMQPLVGTLYQLID---------------QAKRTPVRQ-FRGIVAPGSGGSADKKKA 631 F++ L G + + I + +R +Q P G + + Sbjct: 588 FLKNLKGMIQKYIQKKPHDIQMMAGTEEWKVERHKTQQALSLGKCPRCGHEVLDRNS 644 >UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angulatum DSM 20098 RepID=C4FH65_9BIFI Length = 996 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 129/639 (20%), Positives = 230/639 (35%), Gaps = 92/639 (14%) Query: 2 RLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW 61 +L I E P+ AR I+ L +G V +GH+ + AQP + Sbjct: 6 KLVIVESPTKARKISGYLG-------------DGYTVMASVGHIRDLAQPSQVPAADKEH 52 Query: 62 NLADLPIVPEKWQ--LQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYL 119 V + ++ K + +K L +A E+ A D DREG+ + +++ L Sbjct: 53 YGKFGVDVNDGFKPYYIVGADKRKTVADLKSALKKADELYLATDEDREGEAIAWHLVETL 112 Query: 120 QLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRA 179 + + V+R + +++ A+++++++ R + + R D LYG ++ Sbjct: 113 K----PKVPVKRMVFHEITKNAIKQSLEQTRDVD--ADMVDAQETRRILDRLYGYELS-- 164 Query: 180 YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADER---- 235 +L R G LS GRVQ+ L+V R+ E F ++++ A + + Sbjct: 165 -PVLWRKVGPG--LSAGRVQSVATRLIVERERERMAFTRASYWDIVAKLAAANTQGERVG 221 Query: 236 FTAIWQPSEACEPYQDEEGRL---------------LHRPLAEHVVNRISGQPAIVTSYN 280 F A ++ L + A V + P V S Sbjct: 222 FDARMVSLGGRRLVGSKDFGADGKLTPAGFADNVCQLSQTDAAAVAQELEHAPFTVMSME 281 Query: 281 DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEH 340 K PF+ S LQ A R G+S++ + Q LYE + ITY R+D L E Sbjct: 282 SKPYRRRPLPPFTTSTLQQTAGNRLGMSSRATMRAAQGLYE-NGYITYMRTDSVTLSSEA 340 Query: 341 FAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTA------RSSAIN 394 A + L D + +AH I P A Sbjct: 341 IAAARNAVE--YHFGKSFLSDAPKQYDTKT----AGAQEAHECIRPAGARFHDPDELATR 394 Query: 395 LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDI-----AKGKFVAKARFLAEAGWRTL 449 + ++ K+Y LI ++ L DA +++ + F A + G+ Sbjct: 395 VPSDQLKLYTLIWQRTLASQMADATGSTATVKISAPAGGHGEALFQASGTVIDFPGFMKA 454 Query: 450 LGSKERDEE---------NDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM 500 G + + LP ++ G L + +TQPP +T+A+L+ + Sbjct: 455 TGEQHHAAKQGGRKGENAEGNASLPPMSAGQRLDVADVQADGHETQPPARYTEASLVKTL 514 Query: 501 TGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS 560 +G +T A II + RG++ ++GR + + A+ Sbjct: 515 E-----------------AKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFAVVKL 557 Query: 561 LP---EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLV 596 L TA E+ L QI+ + +D++ Sbjct: 558 LETKFPKLVDYQFTADMENGLDQIAHGKQTGRDWLTRFY 596 >UniRef50_A9KSH4 DNA topoisomerase n=8 Tax=Bacteria RepID=A9KSH4_CLOPH Length = 721 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 182/716 (25%), Positives = 311/716 (43%), Gaps = 95/716 (13%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 L+I+EKPS+A+ A L RK DG++E +VTWC+GHL+ + P++YD +W+ Sbjct: 11 LYISEKPSVAQEFAKALKSNFRKSDGYMES-EDSIVTWCVGHLVTMSYPESYDPALKKWS 69 Query: 63 LADLPIVPEKWQLQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQ 120 L +P +P++++ + PSV+KQ V+K L+ + +I D REG+ + V + Sbjct: 70 LQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAK 129 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + K + +R I+ + + R I + S++ L SA RA+ D+L GIN +R Sbjct: 130 VPKNKEK--RRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVL 187 Query: 181 TILGR-------NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA- 232 ++ ++VGRV T VLG+VVRR+ EI FV F+ V + T Sbjct: 188 SLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDR 247 Query: 233 --DERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQP----------------- 273 D F A+ P +E + AE ++ ++G Sbjct: 248 TFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLA 307 Query: 274 ------------AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYE 321 A + S K+E+++ PL F+L+ LQ E +K F +S L Q+LYE Sbjct: 308 KLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYE 367 Query: 322 THKLITYPRSDCRYLPEEHFAGRHAVMNAI------SVHAPDLLPQPVVDPDIRNRCWDD 375 KL+TYPR+D R L + + + A ++L + R +D Sbjct: 368 -KKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVND 426 Query: 376 KKVDAHHAIIPTARS--SAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGK 433 K++ H+AIIPT + + +L+ +VY I +++L F P AV++K I I Sbjct: 427 KQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTES 486 Query: 434 FVAKARFLAEAGWRTLLGS------------------------------KERDEENDG-- 461 F + R L E G+ + G E EE Sbjct: 487 FFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYD 546 Query: 462 ----TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILR 517 + + KG +L + E +T PP+ + +L+ AM + + D++L+ ++ Sbjct: 547 ATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIK 606 Query: 518 ATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTD--AGKALFHSLP---EMATRPDMTA 572 + G+GT ATRA I+ L K +L+ + T G+ ++ + ++TA Sbjct: 607 GS-GIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTA 665 Query: 573 HWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADK 628 WE LT +S+ +++ L G + ++ + K + K Sbjct: 666 SWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK 721 >UniRef50_A8TWU8 Possible DNA topoisomerase n=3 Tax=alpha proteobacterium BAL199 RepID=A8TWU8_9PROT Length = 894 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 194/675 (28%), Positives = 306/675 (45%), Gaps = 56/675 (8%) Query: 4 FIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNL 63 I EK S A+ + + + + GHLL+ +P+ + RW+ Sbjct: 6 VITEKTSQAKDVRAAVGGRYG------------TILAAEGHLLDLQEPEDVVPEWKRWSS 53 Query: 64 ADL-PIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLA 122 L P + + +L I+ LH A + A D DREGQL+ E+L++ Sbjct: 54 VLLRPEGLYGTRPAVGGNKAAKLKAIREALHTARRVWLATDCDREGQLIGQEILEHCGF- 112 Query: 123 PEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTI 182 R +V R + + Q + + DR R N+++ L +A+AR +AD +Y +++TR T+ Sbjct: 113 ---RGEVLRVMFTAQDTQTIRDSFDRARPNADYAGLYAAAVARRQADQIYNLSLTRTATV 169 Query: 183 LGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQP 242 G + V+ VGRV+TP L +V RR+ EI FV +FE+ A A + FT P Sbjct: 170 TLGK-GARSVVGVGRVKTPTLAIVCRRELEIRQFVPVAYFEITATATVAAGD-FTMRHAP 227 Query: 243 SEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA 302 E R+L R AE ++N + + + + P L +LQ A Sbjct: 228 ----------EKRILRRADAESILNAARDFEGP-LAVRVEDKRQGPPKLHDLPSLQKLCA 276 Query: 303 KRFGLSAQNVLDICQKLYETH--KLITYPRSDCRYLPEEHFAGRHAVMNAIS---VHAPD 357 RFG SA L+I Q+LY+ K+ITYPR++ RYLPE ++ + A Sbjct: 277 SRFGWSAARTLEIAQELYDGQNKKIITYPRAEVRYLPESLIPDVPKIVAGLQVGKSCATI 336 Query: 358 LLPQPVVDPDIRNRCWDDKKVD--AHHAIIPTARSSA------INLTENEAKVYNLIARQ 409 +P P V + + DK ++ +HHA+IP + A L+ +E K+++++AR Sbjct: 337 AVPTPPVIRKGAHGAFHDKGLEGASHHAVIPNVNTVAGLREVWPRLSLDEKKLFDVVARA 396 Query: 410 YLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN--DGTPLPVV 467 YL PD +R+ LD+ F A R + GWR + +E D LP + Sbjct: 397 YLAAMMPDFRYRQTTATLDVRGVPFKASGRQPIDLGWRAAFPEWQPADEKSGDAQLLPPI 456 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 G+ + +++T+PP + + TL+ AM RFV+D+ L+ LR G+GT AT Sbjct: 457 LDGETARLRDAAIEDKETRPPPRYNEGTLIEAMQNAWRFVEDEALRNRLREAKGIGTPAT 516 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSL---PEMATRPDMTAHWESVLTQISEK 584 RA II L ++ FL +G+ I TD G ALF L P +TA E +L + Sbjct: 517 RAEIIAGLKRQQFLVAQGKAIVPTDTGLALFDVLRQADPALVDPGVTAQLECLLDDVVVG 576 Query: 585 QCRYQDFMQPLVGTLYQLIDQAKR-TPVRQFRGIVAPGSGGSADKKKAAPRKRSAKK--- 640 + D + + G ++I TP+ + G D+ A KR A+ Sbjct: 577 KQAMIDAIDAVCGVAQRIIGNLTSGTPIVSAALLGGRSVGPRTDRPPTAAMKRFAESIAR 636 Query: 641 ----SPPADEVGSGA 651 +PPA S A Sbjct: 637 RKRIAPPAGYATSSA 651 >UniRef50_Q55KM2 DNA topoisomerase n=3 Tax=Agaricomycotina RepID=Q55KM2_CRYNE Length = 1059 Score = 468 bits (1204), Expect = e-130, Method: Composition-based stats. Identities = 121/649 (18%), Positives = 245/649 (37%), Gaps = 73/649 (11%) Query: 1 MR-LFIAEKPSLARAIADVLPKP----------HRKGDGFIEC---------GNGQVVTW 40 MR L +AEKPS+A++I ++L + + F+ G VT Sbjct: 1 MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTA 60 Query: 41 CIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN-VIKRFLHEASEIV 99 +GHL +D + +W D + + + K + ++ A ++ Sbjct: 61 VLGHL----TSSDFDDDHRKWGSCDPFALFDAPVITFVDQKLKTVESNLQIEARNADILM 116 Query: 100 HAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLC 159 D DREG+ + EV+ + + V+R + + P + +A + + Sbjct: 117 IWTDCDREGEHIGSEVVAACK-KVNRNILVKRARFSAIIPAQIHQACRQANDLD--MRQA 173 Query: 160 VSALARARADWLYGINMTRAYTILGR---NAGYQGVLSVGRVQTPVLGLVVRRDEEIENF 216 + R D G TR T+ + + ++S G Q P LG VV + ++ F Sbjct: 174 DAVATRISLDLKVGSAFTRLTTMTLQVRVPDLAEQLISYGPCQFPTLGFVVEQYTRVQAF 233 Query: 217 VAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRIS-GQPAI 275 V + F+ + + ++ + ++ + L LA + + + Sbjct: 234 VPETFWYIFVALEREHEDG-------EPSTVEFRWKRNHLFDLDLAAVLYEQCTVNPQTR 286 Query: 276 VTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRY 335 V K ++ PLP + LQ ++ ++ + +LD+ +KLY+ +++YPR++ Sbjct: 287 VLKVESKPATKWKPLPLTTVELQQSGSRLLHMTPKRILDLAEKLYQ-KGIVSYPRTETDQ 345 Query: 336 LPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL 395 + + Q ++D + K AH I PT + A NL Sbjct: 346 YDPKFDFNSLIQKQTLDNQWGAY-AQKLLDGAFQKPRNGRKNDKAHPPIHPT--AHAGNL 402 Query: 396 TENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKER 455 +E +V+ LI R++L +A + +E+ IA F + + + Sbjct: 403 EGDERRVFELITRRFLASCSTNAEGQNTTVEISIADEIFSTTGLVVLRRNYLEVYPY--- 459 Query: 456 DEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKI 515 ++ LP +G+ + + ++ E T P T+A L+ M Sbjct: 460 -DKWATHALPNFEEGEVFIPDVIDLKEGTTSRPSLLTEADLVGLMDK------------- 505 Query: 516 LRATDGLGTEATRAGIIELLFKRGFLTKKG----RYIHSTDAGKALFH-----SLPEMAT 566 +G+GT+AT A I + +RG++T+K +Y+ + G L + Sbjct: 506 ----NGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGIGLVEGFNAIGFDRSLS 561 Query: 567 RPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR 615 +P + E + I + ++ +Q + ++ +A+R Sbjct: 562 KPHLRRETEHRMQLICDGVRGKREILQTTIEEYKEVFVKARREFQTVID 610 >UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DGI7_9EURY Length = 727 Score = 467 bits (1202), Expect = e-130, Method: Composition-based stats. Identities = 160/679 (23%), Positives = 269/679 (39%), Gaps = 76/679 (11%) Query: 1 MR-LFIAEKPSLARAIADVLPKPHRK-----GDGFIECGNGQ---VVTWCIGHLLEQAQP 51 M+ L IAEKPS+A IA L K + +G V +GHL Q Sbjct: 1 MKTLIIAEKPSVALRIAIALGNGQHKSVRNGRITYYTMPHGDGEIYVAAAVGHLFTIRQK 60 Query: 52 DAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLL 111 + + + ++ P + + L +K+ E S ++A D D EG ++ Sbjct: 61 ----GKERAYPITEIEWAPSYLTNKRSEYTKEYLFTLKKLAQECSTFINACDYDIEGTVI 116 Query: 112 VDEVL-DYLQLAPEKRQQV-QRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARAD 169 ++ + L E V +R + P+ + + L + + AR D Sbjct: 117 GTNIIKELSGLQAEAIGSVSKRMKFSTTTPKDLLDSFGSLLPPD--INNFYAGEARHMLD 174 Query: 170 WLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIV 229 WL+GIN +RA T ++G LS+GRVQ P LGL+ +R++EI +F + ++ V A+ Sbjct: 175 WLWGINFSRALTSALSSSGQYKQLSIGRVQGPALGLLAKREKEIASFKPEPYWNVLAY-- 232 Query: 230 TPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYNDKRESES 287 + + G + + AE + + A+V+ + Sbjct: 233 --------------SGEFEFINSRGNIFAKQEAESAFSAANSGRDNAVVSEATSAEQLRR 278 Query: 288 APLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAV 347 PF L++LQ+EA++ FG L + Q LYE I+YPR+ + LP + Sbjct: 279 PYPPFDLTSLQLEASRVFGFDPSATLAMAQSLYE-RSFISYPRTSSQKLPRT-LGLPRII 336 Query: 348 MNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIA 407 + A + + K+ +AH AI PT + +T +E K+Y+LIA Sbjct: 337 ADLGKNPAYSTIAAEIASKGRFTPAEGPKEDEAHPAIFPTGVTPK-GITGSEEKLYDLIA 395 Query: 408 RQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVV 467 R++L F A +E+ I F K + GW + E LP + Sbjct: 396 RRFLSCFGEYAKVNNFSLEISIGGETFEGKGSKVTYPGWLDYYKYAKIKE----RDLPNL 451 Query: 468 AKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEAT 527 KG + ++ E QT PP+ FT A L+S + LGT+AT Sbjct: 452 EKGQRVEITDIKMPELQTAPPKRFTKAGLISELEK-----------------HNLGTKAT 494 Query: 528 RAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPE---MATRPDMTAHWESVLTQISEK 584 RA II+ LFKR ++ G I T+ G ++ +L + M D T E + IS+ Sbjct: 495 RAAIIDTLFKRNYIE--GSSIRVTEFGMTVYDALEKNCSMIVDEDTTITLEKDMDLISKG 552 Query: 585 QCRYQDFMQPLVGTL-----------YQLIDQAKRTPVRQFRGIVAPGSGGSADKKKA-A 632 + + ++ L ++ ++ K + P GG K++ Sbjct: 553 KMPESEVLKKGKEVLLTAIETFNSNKEKISEEMKESFKSANVLGKCPKDGGDLVIKRSFR 612 Query: 633 PRKRSAKKSPPADEVGSGA 651 ++ A + P Sbjct: 613 GKQFVACSNYPKCTNTYPL 631 >UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales RepID=A7I6L6_METB6 Length = 942 Score = 467 bits (1202), Expect = e-130, Method: Composition-based stats. Identities = 151/672 (22%), Positives = 267/672 (39%), Gaps = 69/672 (10%) Query: 1 MRLFIAEKPSLARAIADVLPKPHR----KGDGFIECGNGQVVT-WCIGHLLEQAQPDAYD 55 M L +AEK A IA +L R K G G +T GH++E ++ Sbjct: 1 MHLIVAEKNISAHRIAQILAGGTRVIEKKDAGVSTYSFGDTITVGLRGHVVEV----DFE 56 Query: 56 SRYARWNLADL-PIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDE 114 Y W P + P+ + ++++++ A + A D D EG+L+ E Sbjct: 57 PGYENWRSEKYTPRSLIDAKTIKVPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKE 116 Query: 115 VLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGI 174 + ++ A K ++ R + + Q + A L + AR D ++G Sbjct: 117 AYELVR-AVNKNVKIDRARFSAITAQEIGSAFANTTDLD--FALAAAGEARQSIDLMWGA 173 Query: 175 NMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADE 234 ++TR ++ + G +LSVGRVQ+P L ++V R++EIE FV + ++++ + A E Sbjct: 174 SLTRFISLAAKRGGNN-ILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQL-GLLTEKAGE 231 Query: 235 RFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSL 294 + A GR + AE +R +P +VT + + + +P PF Sbjct: 232 QIEARHT-----------NGRFKDQKAAELARDRTK-EPLVVTEVREGTKQDRSPSPFDT 279 Query: 295 SALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVH 354 + + AA+ G SA N + I ++LY + I+YPR+D P + V+ I Sbjct: 280 TTYIVAAAR-LGFSAANAMRIAEELY-MNGYISYPRTDNTVYPAS--LDLNGVLATIRNS 335 Query: 355 APDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQF 414 ++ K H I PT ++ + ++ ++Y L+ R++L Sbjct: 336 PFTKDVDWIISHRRAEPTRGKKSSTDHPPIYPTGVATREGIGDDAFRIYELVLRRFLATL 395 Query: 415 CPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELL 474 PDA+++ + + + L E GW + E E T LP G++L Sbjct: 396 APDALWKTLKVNFEAGGETYTVTGGLLLEPGWHAVYPFSEAKE----TILPAFVTGEKLP 451 Query: 475 CEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL 534 K + E++T PP +T + L+ M + LGT++TR +I Sbjct: 452 IRKVNLEEKETLPPARYTQSKLIQRMEELG-----------------LGTKSTRHEVIAR 494 Query: 535 LFKRGFLTKKGRYIHSTDAGKALFHSLP---EMATRPDMTAHWESVLTQISEKQCRYQDF 591 L R ++ G + T G+ + +L + T+P+MT ES + QI E + D Sbjct: 495 LVSRKYIE--GNPLRPTLVGRVVTEALEQNADTITKPEMTQTIESHMQQIKESKRTRDDV 552 Query: 592 MQPLVGTLYQLIDQAKRTPV-----------RQFRGIVAPGSGGSADKKKAAP-RKRSAK 639 + L++ DQ + + P GG+ K + Sbjct: 553 IAESRSMLHKAFDQLEANEQVIGNDIRDRTAEELNLGRCPACGGTLAIKHMRGSTQFIGC 612 Query: 640 KSPPADEVGSGA 651 P G Sbjct: 613 SRYPECTFNIGL 624 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 467 bits (1202), Expect = e-130, Method: Composition-based stats. Identities = 152/671 (22%), Positives = 270/671 (40%), Gaps = 76/671 (11%) Query: 1 MR-LFIAEKPSLARAIADVL-PKPHRKGDG------FIECGNGQVVTWCIGHLLEQAQPD 52 M + I EKP + IA L P +K G +E + +GHL Sbjct: 8 MHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQ 67 Query: 53 AYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLV 112 + + DL P + + V LNVI++F A +HA D D EG L+ Sbjct: 68 S-----NEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIG 122 Query: 113 DEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLY 172 L Y E ++ R + L + ++RA S AR D+++ Sbjct: 123 FNALKY-GCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVD--YGQVDSGAARHILDFIF 179 Query: 173 GINMTRAYTILGRNAGYQGV-LSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTP 231 G+N++R+ + A + + LS GRVQTP L ++V R++EI +F ++ ++A + Sbjct: 180 GVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEG 239 Query: 232 ADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLP 291 + + G++ R L + ++ + G A V + P+P Sbjct: 240 IIA---------------ESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVP 284 Query: 292 FSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAI 351 F L LQ EA + FG S + I Q LY T +YPR+ + LPE ++ + Sbjct: 285 FDLGTLQSEAYRVFGFSPKKTQTIAQNLY-TEGYTSYPRTSSQKLPESIGYE--KILKNL 341 Query: 352 SVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYL 411 + + + + ++ K+ DAH AI PT + L+++E KVY+LI +++ Sbjct: 342 AKNPRFGVHIERLRGPLKPHE-GKKEDDAHPAIHPTGLLPS-ELSKDEKKVYDLIVHRFI 399 Query: 412 MQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGD 471 F DA+ + +EL+I + +F + +++AGW + ++E P ++ GD Sbjct: 400 SVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEE----FPEISGGD 455 Query: 472 ELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGI 531 L ER+T+PP + +A+L+ + GLGT++TRA I Sbjct: 456 SLAVRSVSADERETKPPARYNEASLIRELER-----------------RGLGTKSTRADI 498 Query: 532 IELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQISEKQCRY 588 I L+ R ++ G+ I + G+ + +L ++T +E L I + Sbjct: 499 IAKLYDRKYIE--GKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISK 556 Query: 589 QDFMQPLVGTLYQLIDQAKRTPVRQFRG-----------IVAPGSGGSADKKKAAPRK-- 635 + + + ++ + + P GG K + + Sbjct: 557 DRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRST 616 Query: 636 RSAKKSPPADE 646 S P Sbjct: 617 FVGCSSYPDCR 627 Score = 46.1 bits (108), Expect = 0.004, Method: Composition-based stats. Identities = 6/44 (13%), Positives = 10/44 (22%) Query: 607 KRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSG 650 K+ + P G K+ + K P Sbjct: 668 KKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCS 711 >UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genome shotgun sequence n=3 Tax=Paramecium tetraurelia RepID=A0CUH3_PARTE Length = 947 Score = 467 bits (1201), Expect = e-130, Method: Composition-based stats. Identities = 142/633 (22%), Positives = 264/633 (41%), Gaps = 66/633 (10%) Query: 3 LFIAEKPSLARAIADVLPK---------PHRKGDGFIECGNGQVV----TWCIGHLLEQA 49 L +AEKPS+AR+IA+VL + P+ K F Q V T GHL Sbjct: 16 LNVAEKPSVARSIANVLARDHTVEETQSPYNKLFKFNFKFGDQEVEMWITSVTGHLKSLR 75 Query: 50 QPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQL--NVIKRFLHEASEIVHAGDPDRE 107 P Y +W+ D I+ + +++ K+ +K+F E S+++ D DRE Sbjct: 76 YPKQYQ----KWDQWDPIIILKDAEIENIIPNEKRFLEGNLKQFARECSQLILWLDCDRE 131 Query: 108 GQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARAR 167 G+ + EVL+ + + QV R + + +++A+D L+ E L S LAR Sbjct: 132 GENIAFEVLEVCK-DSNPQIQVHRAHFSAVTYIDIKKALDNLKQPDE--NLSNSVLARQE 188 Query: 168 ADWLYGINMTRAYTILGRNAGYQ-GVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKA 226 D G + TR T+L + + V+S G Q P LG VV+R +EI++FV + F+ ++ Sbjct: 189 IDLRIGASFTRFQTLLLQQQFHLQSVISYGPCQIPTLGFVVQRQKEIDSFVKEKFWFIQC 248 Query: 227 HIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESE 286 T Y G + + + R + A +T K + Sbjct: 249 EDQTKCG---------------YNWSRGNIFDEMIVLILFERCFTEQAKITDVQSKEVQK 293 Query: 287 SAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHA 346 P P S + A+K+ +SA +++ +KLY I+YPR++ P ++ Sbjct: 294 WKPYPLSTIEFEKLASKKLKISAHKAMELAEKLYN-RGFISYPRTETNKFPPT-INLQNI 351 Query: 347 VMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINL-TENEAKVYNL 405 + + ++ Q +++ + +K AH I P + T+ E ++Y L Sbjct: 352 IRDQVNHPVWGEFAQSLINCNFDQPRAGNKDDKAHPPIHPVKMMRESDAQTQQEWEIYQL 411 Query: 406 IARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLP 465 I R +L +A + + L + + F + + E + + +E + +P Sbjct: 412 ITRHFLACCSKNAKGSETTVNLQVQEESFYKQGLVILEKNYLEIYPY----DEWSQSQVP 467 Query: 466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTE 525 KGD + ++ +T PP+ T++ L+ M +G+GT+ Sbjct: 468 NYKKGDMIQIT-LKIQNGKTSPPKPMTESELIGLMDK-----------------NGIGTD 509 Query: 526 ATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVLTQIS 582 AT I + +R + KKG+ I T G AL S + +P + A E + +++ Sbjct: 510 ATIHEHINTIQEREYAIKKGQIIKPTKLGLALVESYEMLGFTLHKPHLRAVMEQRMNEVA 569 Query: 583 EKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFR 615 + + + ++ + + ++ Q + + Sbjct: 570 QGTKQKKQIVEATIAEMSDILKQLQEKRSQIIS 602 >UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6V581_NEORI Length = 827 Score = 467 bits (1201), Expect = e-130, Method: Composition-based stats. Identities = 128/666 (19%), Positives = 241/666 (36%), Gaps = 78/666 (11%) Query: 1 MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYAR 60 M + I E P+ +AIA L K R V GH+ Sbjct: 1 MNVLIVESPTKGKAIAQYLGKDFR-------------VLSSFGHVRALPNKKGSVDVTDS 47 Query: 61 WNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ 120 + + + + + + + + A+ + A DPDREG+ + +++ + Sbjct: 48 FEML----------YKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHLVEVFK 97 Query: 121 LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAY 180 + V R + +++ AV+ AI R E L + R D+L G +++ Sbjct: 98 ENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDE--NLVRAQRLRQALDYLVGFSISPVL 155 Query: 181 TILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW 240 G S GRVQ+ L ++ R+ EI F ++++ V ++ Sbjct: 156 WKKL-----PGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQL 210 Query: 241 QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE 300 + E + AE +V I P +V K + PF S +Q Sbjct: 211 SHINGEKL---ERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQT 267 Query: 301 AAKRFGLSAQNVLDICQKLYE-------THKLITYPRSDCRYLPEEHFAGRHAVMNAISV 353 A+ G S + + + QKLYE LITY R+D +L E + Sbjct: 268 ASTVLGFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQ--KK 325 Query: 354 HAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAIN-----LTENEAKVYNLIAR 408 + LP+ V + + +AH AI PT+ LT ++ K+Y LI Sbjct: 326 FGQEYLPESPVLFKKKVK----NAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWE 381 Query: 409 QYLMQFCPDAVFRKCVIELDIAKGKFV--AKARFLAEAGWRTLLGSKERDEENDGTP--L 464 + L DA+ I KF A A L G+ + +N G + Sbjct: 382 RALACQMSDAITSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFI 441 Query: 465 PVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGT 524 +G ++ + T+PP +++A L+ + + +G Sbjct: 442 KKHKEGAQVKVGDVLPTQNFTEPPHRYSEAGLVKHLEELG-----------------IGR 484 Query: 525 EATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWESVLTQI 581 +T A ++ +L +RG+ + + + G+ + L TA E L ++ Sbjct: 485 PSTYATVVSVLQERGYASIVNKSFIPENRGRLVSEFLVHFFSKYVEYHFTAEMEDRLDKV 544 Query: 582 SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS 641 ++ + D +Q + + +++ ++ P+ + V +G A +K + + K Sbjct: 545 ADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFV---NGALAKQKLVSAEVKVGDKC 601 Query: 642 PPADEV 647 P ++ Sbjct: 602 PKCEKG 607 >UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Entamoeba RepID=B0EMC7_ENTDI Length = 607 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 140/640 (21%), Positives = 247/640 (38%), Gaps = 66/640 (10%) Query: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGN---------------GQVVTWCIGHLLE 47 L +AEKPS+A AI+ L + + + N VT GHL Sbjct: 5 LHVAEKPSVANAISYTLSRGQCQKTSGLSKYNSIFEFEKEFKNIGKCTHYVTSVAGHLKG 64 Query: 48 QAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLN-VIKRFLHEASEIVHAGDPDR 106 + + Y W D + + P+ K++ +K + +V D DR Sbjct: 65 I----DFTTAYRSWGSCDPEELFTAPIEKSVPASMKKVELNLKNVAKKCQVLVLWLDCDR 120 Query: 107 EGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARA 166 EG+ + EV++ + +V R N L P + +A + L + + + + R Sbjct: 121 EGENISFEVIEVC-SEVNSKMKVWRAHFNSLVPDEIIKAYNTLTAPNRH--MSEAVDVRQ 177 Query: 167 RADWLYGINMTRAYTILGR---NAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 D G TR T L + A VLS G Q P LG VV R +I+ F + F++ Sbjct: 178 EIDLRTGAAFTRFQTTLLKNKSKALEGKVLSYGACQFPTLGFVVDRYYQIKAFTKETFYK 237 Query: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQ--PAIVTSYND 281 + + + + + RL R + + + A +T + Sbjct: 238 INCVVEKNSI------------LTEFHWDRNRLFDRLICDLLYEDALEHINSATITEILE 285 Query: 282 KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF 341 K + PLP + LQ +K F +S+ + I +KLY + LI+YPR++ P + Sbjct: 286 KSRTNFKPLPLTTVDLQKACSKYFKISSNETMTIAEKLYNS-GLISYPRTETNIFPSDMD 344 Query: 342 AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK 401 + Q +++ I+N +H I PT ++ +L+E E K Sbjct: 345 HE-KQIKMFQENRIYSSYVQELLNGKIKNPRNGKATDKSHPPIHPTRNANLNDLSEKERK 403 Query: 402 VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG 461 +Y+ I R YL DA + I L + F + E + + ++ ++ Sbjct: 404 IYDFIVRNYLANMSDDARGFETKIGLQVGNESFHCNGLMITERNYLNIFPFRKWSDKE-- 461 Query: 462 TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDG 521 +P +G+++ EV +T PP+ T+ L+ M +G Sbjct: 462 --IPEFHEGEKVQLNCFEVSYGETSPPKPLTEPELIQLMDK-----------------NG 502 Query: 522 LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEM---ATRPDMTAHWESVL 578 +GT+AT A I+ + +R ++ K T+ G AL M +RP + A E L Sbjct: 503 IGTDATIAQHIQKIQEREYVIVKQGSFIPTNLGLALVEGYDSMGFEFSRPQLRAETEKEL 562 Query: 579 TQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIV 618 T+I + D + + +L ++A+ + I Sbjct: 563 TKICSGESNKDDVISTFIEQYEELYERAQYNKSKLVNAIK 602 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.140 0.390 Lambda K H 0.267 0.0429 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 3,777,030,791 Number of Sequences: 3077464 Number of extensions: 158284315 Number of successful extensions: 517548 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1316 Number of HSP's successfully gapped in prelim test: 364 Number of HSP's that attempted gapping in prelim test: 501154 Number of HSP's gapped (non-prelim): 2698 length of query: 653 length of database: 1,040,396,356 effective HSP length: 135 effective length of query: 518 effective length of database: 624,938,716 effective search space: 323718254888 effective search space used: 323718254888 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 97 (41.9 bits)