Phyre 2 Results for P52143

Email	l.a.kelley@imperial.ac.uk
Description	P52143
Date	Wed Jan 25 15:20:58 GMT 2012
Unique Job ID	294182ceab3e8127

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3sljA_

Top template information

PDB header:protein transport
Chain: A: PDB Molecule:serine protease espp;
PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant

Confidence and coverage

Confidence:

100.0%

Coverage:

19%

293 residues ( 19% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1266 residues ( 83%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M N R T S P Y Y C R R S V L S L L I S A L I Y A P P G M A A F T T N V I G V V N D E T V D G N Q K V D E R G T T N N T H

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?
? ? ? ? ? ? ? ? ?
? ?
?
? ?
?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence I I N H G Q Q N V H G G V S N G S L I E S G G Y Q D I G S H N N F V G Q A N N T T I N G G R Q S I H D G G I S T G T T I

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ? ? ? ? ? ? ? ?
?
? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence E S G N Q D V Y K G G I S N G T T I K G G A S R V E G G S A N G I L I D G G S Q I V K V Q G H A D G T T I N K S G S Q D

Secondary structure

SS confidence

Disorder
? ? ? ?
?
? ?
?
? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence V V Q G S L A T N T T I N G G R Q Y V E Q S T V E T T T I K N G G E Q R V Y E S R A L D T T I E G G T Q S L N S K S T A

Secondary structure

SS confidence

Disorder
? ?
? ? ? ?
? ?
?
? ? ?
? ? ?
? ? ? ? ? ? ?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence K N T H I Y S G G T Q I V D N T S T S D V I E V Y S G G V L D V R G G T A T N V T Q H D G A I L K T N T N G T T V S G T

Secondary structure

SS confidence

Disorder ? ?
? ? ?
? ?
? ?
?
? ?
?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence N S E G A F S I H N H V A D N V L L E N G G H L D I N A Y G S A N K T I I K D K G T M S V L T N A K A D A T R I D N G G

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence V M D V A G N A T N T I I N G G T Q N I N N Y G I A T G T N I N S G T Q N I K S G G K A D T T I I S S G S R Q V V E K D

Secondary structure

SS confidence

Disorder
? ?
? ?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence G T A I G S N I S A G G S L I V Y T G G I A H G V N Q E T G S A L V A N T G A G T D I E G Y N K L S H F T I T G G E A N

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ? ? ?
? ? ? ? ? ?
?
? ? ? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence Y V V L E N T G E L T V V A K T S A K N T T I D T G G K L I V Q K E A K T D S T R L N N G G V L E V Q D G G E A K H V E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence Q Q S G G A L I A S T T S G T L I E G T N S Y G D A F Y I R N S E A K N V V L E N A G S L T V V T G S R A V D T I I N A

Secondary structure

SS confidence

Disorder
? ?
? ?
? ? ?
? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence N G K M D V Y G K D V G T V L N S A G T Q T I Y A S A T S D K A N I K G G K Q T V Y G L A T E A N I E S G E Q I V D G G

Secondary structure

SS confidence

Disorder ? ? ?
?
? ?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence S T E K T H I N G G T Q T V Q N Y G K A I N T D I V S G L Q Q I M A N G T A E G S I I N G G S Q V V N E G G L A E N S V

Secondary structure

SS confidence

Disorder
? ?
?
?
?
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence L N D G G T L D V R E K G S A T G I Q Q S S Q G A L V A T T R A T R V T G T R A D G V A F S I E Q G A A N N I L L A N G

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ?
?
?
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence G V L T V E S D T S S D K T Q V N M G G R E I V K T K A T A T G T T L T G G E Q I V E G V A N E T T I N D G G I Q T V S

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence A N G E A I K T K I N E G G T L T V N D N G K A T D I V Q N S G A A L Q T S T A N G I E I S G T H Q Y G T F S I S G N L

Secondary structure

SS confidence

Disorder
? ? ?
? ?
? ? ? ?
? ?
?
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence A T N M L L E N G G N L L V L A G T E A R D S T V G K G G A M Q N L G Q D S A T K V N S G G Q Y T L G R S K D E F Q A L

Secondary structure

SS confidence

Disorder ? ?
?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence A R A E D L Q V A G G T A I V Y A G T L A D A S V S G A T G S L S L M T P R D N V T P V K L E G A V R I T D S A T L T L

Secondary structure

SS confidence

Disorder ? ? ? ?
? ?
? ? ? ? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence G N G V D T T L A D L T A A S R G S V W L N S N N S C A G T S N C E Y R V N S L L L N D G D V Y L S A Q T A A P A T T N

Secondary structure

SS confidence

Disorder
? ? ?
? ?
? ?
? ? ? ? ? ? ? ? ? ? ?
? ?
?
?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence G I Y N T L T T N E L S G S G N F Y L H T N V A G S R G D Q L V V N N N A T G N F K I F V Q D T G V S P Q S D D A M T L

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence V K T G G G D A S F T L G N T G G F V D L G T Y E Y V L K S D G N S N W N L T N D V K P N P D P I P N P K P D P K P D P

Secondary structure

SS confidence

Disorder
?
?
? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence K P D P N P K P D P T P D P T P T P V P E K R I T P S T A A V L N M A A T L P L V F D A E L N S I R E R L N I M K A S P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence H N N N V W G A T Y N T R N N V T T D A G A G F E Q T L T G M T V G I D S R N D I P E G I T T L G A F M G Y S H S H I G

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence F D R G G H G S V G S Y S L G G Y A S W E H E S G F Y L D G V V K L N R F K S N V A G K M S S G G A A N G S Y H S N G L

Secondary structure

SS confidence

Disorder ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence G G H I E T G M R F T D G N W N L T P Y A S L T G F T A D N P E Y H L S N G M K S K S V D T R S I Y R E L G A T L S Y N

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence M R L G N G M E V E P W L K A A V R K E F V D D N R V K V N S D G N F V N Y L S G R R G I Y Q A G I K A S F S S T L S G

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . .

Sequence H L G V G Y S H S A G V E S P W N A V A G V N W S F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3slj chain A

Region: 1226 - 1526
Aligned: 293
Modelled: 301
Confidence: 100.0%
Identity: 16%
PDB header:protein transport
Chain: A: PDB Molecule:serine protease espp;
PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant

Phyre2

PDB 3aeh chain B

Region: 1227 - 1526
Aligned: 266
Modelled: 288
Confidence: 100.0%
Identity: 20%
PDB header:hydrolase
Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter;
PDBTitle: integral membrane domain of autotransporter hbp

Phyre2

PDB 3qq2 chain C

Region: 1261 - 1526
Aligned: 248
Modelled: 252
Confidence: 100.0%
Identity: 25%
PDB header:membrane protein/protein transport
Chain: C: PDB Molecule:brka autotransporter;
PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka

Phyre2

PDB 1uyn chain X

Region: 1234 - 1526
Aligned: 272
Modelled: 293
Confidence: 100.0%
Identity: 17%
Fold: Transmembrane beta-barrels
Superfamily: Autotransporter
Family: Autotransporter

Phyre2

PDB 2qom chain B

Region: 1249 - 1526
Aligned: 261
Modelled: 278
Confidence: 100.0%
Identity: 17%
PDB header:hydrolase
Chain: B: PDB Molecule:serine protease espp;
PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain.

Phyre2

PDB 3kvn chain A

Region: 1227 - 1526
Aligned: 291
Modelled: 300
Confidence: 100.0%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:esterase esta;
PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa

Phyre2

PDB 1dab chain A

Region: 647 - 1185
Aligned: 521
Modelled: 525
Confidence: 99.9%
Identity: 16%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pectin lyase-like
Family: Virulence factor P.69 pertactin

Phyre2

PDB 3ml3 chain A

Region: 1036 - 1183
Aligned: 142
Modelled: 144
Confidence: 99.6%
Identity: 21%
PDB header:protein transport
Chain: A: PDB Molecule:outer membrane protein icsa autotransporter;
PDBTitle: crystal structure of the icsa autochaperone region

Phyre2

PDB 3h09 chain B

Region: 527 - 1178
Aligned: 640
Modelled: 652
Confidence: 99.6%
Identity: 17%
PDB header:hydrolase
Chain: B: PDB Molecule:immunoglobulin a1 protease;
PDBTitle: the structure of haemophilus influenzae iga1 protease

Phyre2

PDB 1p4t chain A

Region: 1342 - 1526
Aligned: 149
Modelled: 172
Confidence: 99.3%
Identity: 23%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 2k0l chain A

Region: 1342 - 1526
Aligned: 171
Modelled: 181
Confidence: 99.3%
Identity: 13%
PDB header:membrane protein
Chain: A: PDB Molecule:outer membrane protein a;
PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles.

Phyre2

PDB 1qjp chain A

Region: 1342 - 1526
Aligned: 134
Modelled: 153
Confidence: 99.2%
Identity: 13%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 1g90 chain A

Region: 1343 - 1526
Aligned: 160
Modelled: 179
Confidence: 99.2%
Identity: 16%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 3nb3 chain C

Region: 1342 - 1526
Aligned: 134
Modelled: 151
Confidence: 99.2%
Identity: 14%
PDB header:virus
Chain: C: PDB Molecule:outer membrane protein a;
PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components

Phyre2

PDB 3syj chain A

Region: 527 - 1178
Aligned: 641
Modelled: 652
Confidence: 99.1%
Identity: 12%
PDB header:cell adhesion
Chain: A: PDB Molecule:adhesion and penetration protein autotransporter;
PDBTitle: crystal structure of the haemophilus influenzae hap adhesin

Phyre2

PDB 2x27 chain X

Region: 1341 - 1526
Aligned: 179
Modelled: 186
Confidence: 99.1%
Identity: 12%
PDB header:membrane protein
Chain: X: PDB Molecule:outer membrane protein oprg;
PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa

Phyre2

PDB 3qra chain A

Region: 1350 - 1526
Aligned: 146
Modelled: 160
Confidence: 99.0%
Identity: 14%
PDB header:cell invasion
Chain: A: PDB Molecule:attachment invasion locus protein;
PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis

Phyre2

PDB 2f1t chain B

Region: 1346 - 1526
Aligned: 160
Modelled: 181
Confidence: 98.9%
Identity: 14%
PDB header:membrane protein
Chain: B: PDB Molecule:outer membrane protein w;
PDBTitle: outer membrane protein ompw

Phyre2

PDB 2jmm chain A

Region: 1342 - 1526
Aligned: 146
Modelled: 153
Confidence: 98.9%
Identity: 12%
PDB header:membrane protein
Chain: A: PDB Molecule:outer membrane protein a;
PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein

Phyre2

PDB 1qj8 chain A

Region: 1378 - 1526
Aligned: 131
Modelled: 149
Confidence: 98.8%
Identity: 18%
Fold: Transmembrane beta-barrels
Superfamily: OMPA-like
Family: Outer membrane protein

Phyre2

PDB 2zj6 chain A

Region: 30 - 239
Aligned: 210
Modelled: 210
Confidence: 98.6%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:lipase;
PDBTitle: crystal structure of d337a mutant of pseudomonas sp. mis38 lipase

Phyre2

PDB 2qub chain G

Region: 72 - 336
Aligned: 265
Modelled: 265
Confidence: 98.3%
Identity: 11%
PDB header:hydrolase
Chain: G: PDB Molecule:extracellular lipase;
PDBTitle: crystal structure of extracellular lipase lipa from serratia2 marcescens

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	N	R	T	S	P	Y	Y	C	R	R	S	V	L	S	L	L	I	S	A	L	I	Y	A	P	P	G	M	A	A	F	T	T	N	V	I	G	V	V	N	D	E	T	V	D	G	N	Q	K	V	D	E	R	G	T	T	N	N	T	H
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?					?	?	?	?	?	?	?	?	?				?	?		?		?	?		?											?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	I	I	N	H	G	Q	Q	N	V	H	G	G	V	S	N	G	S	L	I	E	S	G	G	Y	Q	D	I	G	S	H	N	N	F	V	G	Q	A	N	N	T	T	I	N	G	G	R	Q	S	I	H	D	G	G	I	S	T	G	T	T	I
Secondary structure
SS confidence
Disorder															?	?				?								?	?	?	?	?	?	?	?	?	?	?								?				?	?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	E	S	G	N	Q	D	V	Y	K	G	G	I	S	N	G	T	T	I	K	G	G	A	S	R	V	E	G	G	S	A	N	G	I	L	I	D	G	G	S	Q	I	V	K	V	Q	G	H	A	D	G	T	T	I	N	K	S	G	S	Q	D
Secondary structure
SS confidence
Disorder			?	?	?	?			?				?	?									?																?	?				?	?				?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	V	V	Q	G	S	L	A	T	N	T	T	I	N	G	G	R	Q	Y	V	E	Q	S	T	V	E	T	T	T	I	K	N	G	G	E	Q	R	V	Y	E	S	R	A	L	D	T	T	I	E	G	G	T	Q	S	L	N	S	K	S	T	A
Secondary structure
SS confidence
Disorder			?	?		?	?	?	?							?	?				?			?	?	?								?	?	?		?	?	?	?	?	?	?											?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	K	N	T	H	I	Y	S	G	G	T	Q	I	V	D	N	T	S	T	S	D	V	I	E	V	Y	S	G	G	V	L	D	V	R	G	G	T	A	T	N	V	T	Q	H	D	G	A	I	L	K	T	N	T	N	G	T	T	V	S	G	T
Secondary structure
SS confidence
Disorder	?	?							?	?	?			?	?				?	?													?					?	?								?										?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	N	S	E	G	A	F	S	I	H	N	H	V	A	D	N	V	L	L	E	N	G	G	H	L	D	I	N	A	Y	G	S	A	N	K	T	I	I	K	D	K	G	T	M	S	V	L	T	N	A	K	A	D	A	T	R	I	D	N	G	G
Secondary structure
SS confidence
Disorder				?										?														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	V	M	D	V	A	G	N	A	T	N	T	I	I	N	G	G	T	Q	N	I	N	N	Y	G	I	A	T	G	T	N	I	N	S	G	T	Q	N	I	K	S	G	G	K	A	D	T	T	I	I	S	S	G	S	R	Q	V	V	E	K	D
Secondary structure
SS confidence
Disorder																				?	?					?	?																	?	?	?												?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	G	T	A	I	G	S	N	I	S	A	G	G	S	L	I	V	Y	T	G	G	I	A	H	G	V	N	Q	E	T	G	S	A	L	V	A	N	T	G	A	G	T	D	I	E	G	Y	N	K	L	S	H	F	T	I	T	G	G	E	A	N
Secondary structure
SS confidence
Disorder				?	?													?	?	?	?	?	?	?	?		?	?	?	?	?	?			?						?	?	?	?					?	?	?									?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	Y	V	V	L	E	N	T	G	E	L	T	V	V	A	K	T	S	A	K	N	T	T	I	D	T	G	G	K	L	I	V	Q	K	E	A	K	T	D	S	T	R	L	N	N	G	G	V	L	E	V	Q	D	G	G	E	A	K	H	V	E
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?				?																			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	Q	Q	S	G	G	A	L	I	A	S	T	T	S	G	T	L	I	E	G	T	N	S	Y	G	D	A	F	Y	I	R	N	S	E	A	K	N	V	V	L	E	N	A	G	S	L	T	V	V	T	G	S	R	A	V	D	T	I	I	N	A
Secondary structure
SS confidence
Disorder																									?	?				?	?			?	?	?													?	?		?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	N	G	K	M	D	V	Y	G	K	D	V	G	T	V	L	N	S	A	G	T	Q	T	I	Y	A	S	A	T	S	D	K	A	N	I	K	G	G	K	Q	T	V	Y	G	L	A	T	E	A	N	I	E	S	G	E	Q	I	V	D	G	G
Secondary structure
SS confidence
Disorder	?	?	?				?																						?	?														?	?	?	?	?										?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	S	T	E	K	T	H	I	N	G	G	T	Q	T	V	Q	N	Y	G	K	A	I	N	T	D	I	V	S	G	L	Q	Q	I	M	A	N	G	T	A	E	G	S	I	I	N	G	G	S	Q	V	V	N	E	G	G	L	A	E	N	S	V
Secondary structure
SS confidence
Disorder		?	?																										?					?				?													?	?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	L	N	D	G	G	T	L	D	V	R	E	K	G	S	A	T	G	I	Q	Q	S	S	Q	G	A	L	V	A	T	T	R	A	T	R	V	T	G	T	R	A	D	G	V	A	F	S	I	E	Q	G	A	A	N	N	I	L	L	A	N	G
Secondary structure
SS confidence
Disorder																										?			?	?	?	?	?	?	?			?			?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	G	V	L	T	V	E	S	D	T	S	S	D	K	T	Q	V	N	M	G	G	R	E	I	V	K	T	K	A	T	A	T	G	T	T	L	T	G	G	E	Q	I	V	E	G	V	A	N	E	T	T	I	N	D	G	G	I	Q	T	V	S
Secondary structure
SS confidence
Disorder											?	?																			?					?	?	?	?	?					?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	A	N	G	E	A	I	K	T	K	I	N	E	G	G	T	L	T	V	N	D	N	G	K	A	T	D	I	V	Q	N	S	G	A	A	L	Q	T	S	T	A	N	G	I	E	I	S	G	T	H	Q	Y	G	T	F	S	I	S	G	N	L
Secondary structure
SS confidence
Disorder						?	?	?																?	?										?	?	?	?		?	?					?		?	?	?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	A	T	N	M	L	L	E	N	G	G	N	L	L	V	L	A	G	T	E	A	R	D	S	T	V	G	K	G	G	A	M	Q	N	L	G	Q	D	S	A	T	K	V	N	S	G	G	Q	Y	T	L	G	R	S	K	D	E	F	Q	A	L
Secondary structure
SS confidence
Disorder	?	?																																			?		?																?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	A	R	A	E	D	L	Q	V	A	G	G	T	A	I	V	Y	A	G	T	L	A	D	A	S	V	S	G	A	T	G	S	L	S	L	M	T	P	R	D	N	V	T	P	V	K	L	E	G	A	V	R	I	T	D	S	A	T	L	T	L
Secondary structure
SS confidence
Disorder	?	?	?	?										?	?					?	?	?	?	?	?	?												?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	G	N	G	V	D	T	T	L	A	D	L	T	A	A	S	R	G	S	V	W	L	N	S	N	N	S	C	A	G	T	S	N	C	E	Y	R	V	N	S	L	L	L	N	D	G	D	V	Y	L	S	A	Q	T	A	A	P	A	T	T	N
Secondary structure
SS confidence
Disorder				?	?	?										?	?				?	?		?	?	?	?	?	?	?	?	?	?	?			?	?		?		?									?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	G	I	Y	N	T	L	T	T	N	E	L	S	G	S	G	N	F	Y	L	H	T	N	V	A	G	S	R	G	D	Q	L	V	V	N	N	N	A	T	G	N	F	K	I	F	V	Q	D	T	G	V	S	P	Q	S	D	D	A	M	T	L
Secondary structure
SS confidence
Disorder																							?																											?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	V	K	T	G	G	G	D	A	S	F	T	L	G	N	T	G	G	F	V	D	L	G	T	Y	E	Y	V	L	K	S	D	G	N	S	N	W	N	L	T	N	D	V	K	P	N	P	D	P	I	P	N	P	K	P	D	P	K	P	D	P
Secondary structure
SS confidence
Disorder												?			?																		?	?	?	?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	K	P	D	P	N	P	K	P	D	P	T	P	D	P	T	P	T	P	V	P	E	K	R	I	T	P	S	T	A	A	V	L	N	M	A	A	T	L	P	L	V	F	D	A	E	L	N	S	I	R	E	R	L	N	I	M	K	A	S	P
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?										?	?							?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	H	N	N	N	V	W	G	A	T	Y	N	T	R	N	N	V	T	T	D	A	G	A	G	F	E	Q	T	L	T	G	M	T	V	G	I	D	S	R	N	D	I	P	E	G	I	T	T	L	G	A	F	M	G	Y	S	H	S	H	I	G
Secondary structure
SS confidence
Disorder	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?																																		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	F	D	R	G	G	H	G	S	V	G	S	Y	S	L	G	G	Y	A	S	W	E	H	E	S	G	F	Y	L	D	G	V	V	K	L	N	R	F	K	S	N	V	A	G	K	M	S	S	G	G	A	A	N	G	S	Y	H	S	N	G	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?				?																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	G	G	H	I	E	T	G	M	R	F	T	D	G	N	W	N	L	T	P	Y	A	S	L	T	G	F	T	A	D	N	P	E	Y	H	L	S	N	G	M	K	S	K	S	V	D	T	R	S	I	Y	R	E	L	G	A	T	L	S	Y	N
Secondary structure
SS confidence
Disorder																															?				?	?	?	?	?					?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	M	R	L	G	N	G	M	E	V	E	P	W	L	K	A	A	V	R	K	E	F	V	D	D	N	R	V	K	V	N	S	D	G	N	F	V	N	Y	L	S	G	R	R	G	I	Y	Q	A	G	I	K	A	S	F	S	S	T	L	S	G
Secondary structure
SS confidence
Disorder					?																					?				?	?	?	?	?	?	?	?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.
Sequence	H	L	G	V	G	Y	S	H	S	A	G	V	E	S	P	W	N	A	V	A	G	V	N	W	S	F
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?												?
Disorder confidence