BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (217 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E...   379   e-104
UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E...   264   1e-69
UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E...   257   2e-67
UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E...   245   6e-64
UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E...   237   2e-61
UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q...   234   1e-60
UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae ...   218   1e-55
UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandens...   217   3e-55
UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testost...   215   8e-55
UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumo...   209   7e-53
UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella dranco...   205   1e-51
UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E...   204   1e-51
UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   196   5e-49
UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   195   8e-49
UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter Re...   189   7e-47
UniRef50_Q4FV02 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   185   1e-45
UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q...   184   1e-45
UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr06...   181   2e-44
UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp....   177   2e-43
UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales R...   176   4e-43
UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E...   173   3e-42
UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria ...   169   6e-41
UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   168   1e-40
UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2...   164   1e-39
UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   161   2e-38
UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   160   2e-38
UniRef50_C6W5I1 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...   155   8e-37
UniRef50_A5GM98 Pseudouridine synthase n=3 Tax=Synechococcus Rep...   147   3e-34
UniRef50_C8PVP6 RNA pseudouridine synthase family protein n=1 Ta...   147   3e-34
UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=...   129   9e-29
UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibac...   127   2e-28
UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   125   8e-28
UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   124   3e-27
UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus m...   121   1e-26
UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   120   3e-26
UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium Rep...   119   7e-26
UniRef50_A3QB38 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3...   118   2e-25
UniRef50_A6BL18 Pseudouridine synthase Rsu (Fragment) n=1 Tax=Le...   118   2e-25
UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   117   3e-25
UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepI...   115   7e-25
UniRef50_A4BXB5 Pseudouridine synthase n=2 Tax=Bacteroidetes Rep...   115   9e-25
UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3...   114   2e-24
UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=...   113   3e-24
UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria Rep...   113   4e-24
UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   112   8e-24
UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta...   111   1e-23
UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=...   110   3e-23
UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A...   110   4e-23
UniRef50_A8FRI1 Pseudouridine synthase n=17 Tax=Bacteria RepID=A...   110   4e-23
UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   109   7e-23
UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q2...   109   7e-23
UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueg...   109   8e-23
UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr03...   108   9e-23
UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B...   108   1e-22
UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine...   107   2e-22
UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine syn...   107   3e-22
UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyr...   107   3e-22
UniRef50_C5KJS4 Pseudouridine synthase, putative n=2 Tax=Perkins...   107   4e-22
UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracel...   106   4e-22
UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium r...   106   5e-22
UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   106   6e-22
UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium Re...   106   6e-22
UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9...   105   8e-22
UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   105   9e-22
UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter the...   105   1e-21
UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B...   105   1e-21
UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadale...   103   3e-21
UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID...   103   4e-21
UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula m...   103   4e-21
UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae...   103   5e-21
UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales Rep...   103   5e-21
UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium c...   102   1e-20
UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdello...   101   1e-20
UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6...   101   2e-20
UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae Re...   101   2e-20
UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5...   100   2e-20
UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termit...   100   3e-20
UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   100   4e-20
UniRef50_Q1RJR2 Uncharacterized RNA pseudouridine synthase RBE_0...   100   5e-20
UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomona...   100   6e-20
UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3...   100   6e-20
UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1...   100   6e-20
UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   100   6e-20
UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...    99   7e-20
UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0...    99   8e-20
UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae Re...    99   9e-20
UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Soliba...    99   1e-19
UniRef50_C8N9M2 RNA pseudouridine synthase family protein n=1 Ta...    98   2e-19
UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacter...    98   2e-19
UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5...    98   2e-19
UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...    98   2e-19
UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapol...    98   2e-19
UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria Re...    97   3e-19
UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin51...    97   3e-19
UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID...    97   4e-19
UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_14...    97   4e-19
UniRef50_A9BF27 Pseudouridine synthase n=1 Tax=Petrotoga mobilis...    97   5e-19
UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=...    97   5e-19
UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae ...    97   5e-19
UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes Rep...    97   5e-19
UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterinea...    97   6e-19
UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacter...    96   6e-19
UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus...    96   6e-19
UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum fe...    96   6e-19
UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...    96   8e-19
UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID...    96   1e-18
UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter rube...    95   1e-18
UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actino...    95   1e-18
UniRef50_Q2NZN4 Pseudouridine synthase n=13 Tax=Xanthomonadaceae...    95   1e-18
UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales ...    95   1e-18
UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna ...    95   1e-18
UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroid...    95   2e-18
UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...    95   2e-18
UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organism...    94   2e-18
UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodi...    94   3e-18
UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales R...    94   3e-18
UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae...    94   3e-18
UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q...    94   3e-18
UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales Rep...    94   4e-18
UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi...    94   4e-18
UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0...    94   4e-18
UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8...    94   4e-18
UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus Re...    94   4e-18
UniRef50_Q1D9N8 Pseudouridine synthase n=4 Tax=Cystobacterineae ...    94   5e-18
UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae...    93   5e-18
UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis...    93   5e-18
UniRef50_Q11WC7 Pseudouridine synthase n=2 Tax=Sphingobacteriale...    93   5e-18
UniRef50_UPI0001C337CA ribosomal large subunit pseudouridine syn...    93   5e-18
UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus Re...    93   6e-18
UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenen...    93   6e-18
UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales R...    93   7e-18
UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytop...    93   7e-18
UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...    93   7e-18
UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1...    92   1e-17
UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales Rep...    92   1e-17
UniRef50_B8DUD9 Pseudouridine synthase n=8 Tax=Bifidobacterium R...    92   1e-17
UniRef50_A5Z4I7 Pseudouridine synthase n=1 Tax=Eubacterium ventr...    92   2e-17
UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gas...    92   2e-17
UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9...    91   2e-17
UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus...    91   2e-17
UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis exc...    91   2e-17
UniRef50_C5CGJ5 Pseudouridine synthase n=1 Tax=Kosmotoga olearia...    91   3e-17
UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succi...    91   3e-17
UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vag...    91   3e-17
UniRef50_C1FHS6 Predicted protein (Fragment) n=4 Tax=Mamiellales...    90   4e-17
UniRef50_A0CY18 Chromosome undetermined scaffold_30, whole genom...    90   5e-17
UniRef50_B3DRY9 Pseudouridine synthase n=7 Tax=Bifidobacterium R...    90   6e-17
UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae ...    89   8e-17
UniRef50_Q0F269 Pseudouridine synthase n=1 Tax=Mariprofundus fer...    89   8e-17
UniRef50_C7NDY8 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...    89   9e-17
UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marin...    89   1e-16
UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koriba...    89   1e-16
UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q0...    89   1e-16
UniRef50_B1X5I1 Pseudouridine synthase, Rsu n=1 Tax=Paulinella c...    89   1e-16
UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutac...    89   1e-16
UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limn...    89   1e-16
UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredi...    88   2e-16
UniRef50_B6W7S5 Pseudouridine synthase n=2 Tax=Anaerococcus RepI...    88   2e-16
UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae ...    88   2e-16
UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacter...    88   2e-16
UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine syn...    88   2e-16
UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella el...    88   2e-16
UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae Rep...    88   2e-16
UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. ...    88   2e-16
UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uen...    88   2e-16
UniRef50_Q3Z8C8 Pseudouridine synthase n=5 Tax=Dehalococcoides R...    88   2e-16
UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indi...    88   3e-16
UniRef50_Q9I5J6 Ribosomal small subunit pseudouridine synthase A...    87   3e-16
UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gin...    87   3e-16
UniRef50_D2UX35 Predicted protein n=1 Tax=Naegleria gruberi RepI...    87   4e-16
UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae Rep...    87   4e-16
UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria Re...    87   5e-16
UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pine...    87   6e-16
UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepI...    86   6e-16
UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...    86   6e-16
UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas Rep...    86   7e-16
UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi A...    86   8e-16
UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrional...    86   8e-16
UniRef50_A1K3P0 Pseudouridylate synthase n=3 Tax=Betaproteobacte...    86   8e-16
UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alex...    86   9e-16
UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria R...    86   1e-15
UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID...    86   1e-15
UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C...    86   1e-15
UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ...    86   1e-15
UniRef50_C6VS09 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...    85   1e-15
UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72...    85   1e-15
UniRef50_O05668 Uncharacterized RNA pseudouridine synthase ML137...    85   1e-15
UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales Rep...    85   1e-15
UniRef50_Q0AS26 Pseudouridine synthase n=1 Tax=Maricaulis maris ...    85   1e-15
UniRef50_A5CX60 Pseudouridine synthase n=1 Tax=Candidatus Vesico...    85   2e-15
UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepI...    85   2e-15
UniRef50_A0LG30 Pseudouridine synthase n=1 Tax=Syntrophobacter f...    85   2e-15
UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteri...    85   2e-15
UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter hepari...    85   2e-15
UniRef50_C2KPR0 Pseudouridine synthase n=3 Tax=Mobiluncus RepID=...    85   2e-15
UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium R...    84   2e-15
UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3...    84   2e-15
UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphe...    84   3e-15
UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q1...    84   3e-15
UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silv...    84   3e-15
UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacter...    84   3e-15
UniRef50_D1N1S2 Pseudouridine synthase n=1 Tax=Victivallis vaden...    84   3e-15
UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wo...    84   3e-15
UniRef50_A5ZYR1 Pseudouridine synthase n=2 Tax=Clostridiales Rep...    84   3e-15
UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=...    84   4e-15
UniRef50_A6DF49 Pseudouridine synthase n=1 Tax=Lentisphaera aran...    84   4e-15
UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii ...    83   5e-15
UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5...    83   5e-15
UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nod...    83   6e-15
UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax...    83   6e-15
UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1...    83   6e-15
UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacte...    83   7e-15
UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacte...    83   7e-15
UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales Rep...    83   8e-15
UniRef50_B2UKZ1 Pseudouridine synthase n=1 Tax=Akkermansia mucin...    82   9e-15
UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum v...    82   9e-15
UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organism...    82   1e-14
UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (...    82   1e-14
UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovib...    82   1e-14
UniRef50_A8I6C3 Pseudouridine synthase n=6 Tax=Alphaproteobacter...    82   1e-14
UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B...    82   1e-14
UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...    82   1e-14
UniRef50_B7G1P9 Predicted protein n=1 Tax=Phaeodactylum tricornu...    82   1e-14
UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteri...    82   2e-14
UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=...    82   2e-14
UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium fe...    82   2e-14
UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K...    82   2e-14
UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacter...    82   2e-14
UniRef50_C9RMB6 Pseudouridine synthase n=1 Tax=Fibrobacter succi...    81   2e-14
UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus...    81   2e-14
UniRef50_C0BLA3 Pseudouridine synthase n=1 Tax=Flavobacteria bac...    81   2e-14
UniRef50_C6XHY6 Pseudouridine synthase n=1 Tax=Candidatus Liberi...    81   3e-14
UniRef50_C5EVC9 Pseudouridine synthase n=6 Tax=Clostridiales Rep...    81   3e-14
UniRef50_A6BG46 Putative uncharacterized protein n=2 Tax=Clostri...    81   3e-14
UniRef50_B5YMC9 Predicted protein n=1 Tax=Thalassiosira pseudona...    81   3e-14
UniRef50_Q605S3 Pseudouridine synthase n=1 Tax=Methylococcus cap...    81   3e-14
UniRef50_Q21JF0 Pseudouridine synthase n=2 Tax=Gammaproteobacter...    80   3e-14
UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia ...    80   4e-14
UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter Re...    80   4e-14
UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflex...    80   4e-14
UniRef50_Q30NZ7 Pseudouridine synthase n=3 Tax=Campylobacterales...    80   4e-14
UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae Rep...    80   4e-14
UniRef50_D0L0G8 Pseudouridine synthase n=1 Tax=Halothiobacillus ...    80   4e-14
UniRef50_Q4Z2R8 Pseudouridine synthetase, putative n=3 Tax=Plasm...    80   5e-14
UniRef50_C7RHU0 Pseudouridine synthase n=3 Tax=Anaerococcus RepI...    80   5e-14
UniRef50_Q2G8T2 Pseudouridine synthase n=5 Tax=Sphingomonadales ...    80   6e-14
UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteri...    80   7e-14
UniRef50_A1S9T3 Pseudouridine synthase n=1 Tax=Shewanella amazon...    79   7e-14
UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales Re...    79   9e-14
UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (c...    79   1e-13

>UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Enterobacteriaceae RepID=RLUE_SALTY
          Length = 221

 Score =  379 bits (972), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 179/215 (83%), Positives = 198/215 (92%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           MRQ I SENTMQKTSFRNH VKRFSS+++++ + ENQP RV+LFNKPYDVLPQFTDEAGR
Sbjct: 1   MRQLISSENTMQKTSFRNHYVKRFSSRQASKSRKENQPKRVVLFNKPYDVLPQFTDEAGR 60

Query: 61  KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +TLK+FIPVQGVYAAGRLDRDSEGLLVLTN+GALQARLTQPGKRTGKIYYVQVEGIP   
Sbjct: 61  RTLKDFIPVQGVYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGIPDNA 120

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           AL+ALR GVTLNDGPTLPAG E+V EP WLWPR PPIRERK+IPTSWLK+TLYEGRNRQV
Sbjct: 121 ALQALRTGVTLNDGPTLPAGIEIVAEPDWLWPRTPPIRERKNIPTSWLKVTLYEGRNRQV 180

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RRMTAHVG PTLRLIRY+MGDY+L+ L NG+WRE+
Sbjct: 181 RRMTAHVGHPTLRLIRYSMGDYTLNGLDNGQWREI 215


>UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E n=107 Tax=Bacteria
           RepID=RLUE_VIBCH
          Length = 241

 Score =  264 bits (675), Expect = 1e-69,   Method: Compositional matrix adjust.
 Identities = 126/177 (71%), Positives = 148/177 (83%), Gaps = 1/177 (0%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +VILFNKPYD L QFTD  GRKTL ++IP++ VYAAGRLDRDSEGLL+LTN+G LQARLT
Sbjct: 65  KVILFNKPYDTLSQFTDGDGRKTLADYIPIKDVYAAGRLDRDSEGLLILTNDGILQARLT 124

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           QP  +  K Y+VQVEG P +  LEALR+GVTL DGPTLPA  +++ EP  LWPRNPP+R 
Sbjct: 125 QPQSKAPKTYWVQVEGSPQESDLEALRHGVTLKDGPTLPAKVDIMPEPT-LWPRNPPVRF 183

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R +IPT+WL ITL EGRNRQVRRMTAH+GFPTLRLIRY+MGD++L +L  GEWREVT
Sbjct: 184 RAAIPTTWLAITLMEGRNRQVRRMTAHIGFPTLRLIRYSMGDWNLGDLQPGEWREVT 240


>UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E n=61 Tax=Bacteria
           RepID=RLUE_PASMU
          Length = 241

 Score =  257 bits (656), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 127/219 (57%), Positives = 155/219 (70%), Gaps = 13/219 (5%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQP-------------TRVILFNKPYDVLPQFTDEA 58
           QKT  R   ++  + +++   KP+ +P             T+VILFNKPYDVL QF+DE 
Sbjct: 9   QKTKPRPSSLRSVNKRKAAEIKPQKRPLSFRQKKTVNFAETQVILFNKPYDVLTQFSDEE 68

Query: 59  GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           GR TLK FIP+  VY AGRLDRDSEGL++LTNNG +Q RL  P   T K Y+ QVEGIP 
Sbjct: 69  GRATLKAFIPIPHVYPAGRLDRDSEGLVLLTNNGEIQHRLAVPKFNTEKTYFAQVEGIPQ 128

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           +  L  LR GV LNDG TLPA   LV EP WLW RNPPIRERK IPTSWL+I ++EGRNR
Sbjct: 129 ETDLAQLRQGVVLNDGKTLPAKVRLVPEPNWLWQRNPPIRERKQIPTSWLEIKIHEGRNR 188

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           QVRRMTAH+GFPTLRLIRY M  ++L NL  G++R++++
Sbjct: 189 QVRRMTAHIGFPTLRLIRYQMALFNLANLEQGQYRQLSE 227


>UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E n=244 Tax=Bacteria
           RepID=RLUE_VIBPA
          Length = 238

 Score =  245 bits (626), Expect = 6e-64,   Method: Compositional matrix adjust.
 Identities = 115/179 (64%), Positives = 143/179 (79%), Gaps = 1/179 (0%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           Q  +VI+FNKPYD L QFTD  GRKTL ++IPV+ VYAAGRLDRDSEGL+VLTN+G LQA
Sbjct: 59  QNRKVIIFNKPYDTLSQFTDGDGRKTLADYIPVKDVYAAGRLDRDSEGLMVLTNDGILQA 118

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           +LTQP  ++ K Y+VQV+G P +  LE LR GV L DG TLPA  E++D P  +W RNPP
Sbjct: 119 KLTQPKSKSPKTYWVQVDGAPQEQDLEKLRKGVELKDGMTLPAKVEVIDAPT-IWERNPP 177

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +R R +IPT+WL IT+ EGRNRQVRRMTAH+GFPTLRL+RY+MGD +L +L  G+W+E+
Sbjct: 178 VRFRANIPTTWLAITIIEGRNRQVRRMTAHIGFPTLRLVRYSMGDITLGDLQPGQWKEI 236


>UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Proteobacteria RepID=RLUE_PSEAE
          Length = 189

 Score =  237 bits (605), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 119/184 (64%), Positives = 143/184 (77%), Gaps = 2/184 (1%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNN 91
           + P ++P +++LFNKP+DVL QF DE GR TLK+FIPV GVY AGRLDRDSEGLL+LTN+
Sbjct: 3   KAPPSEP-KLLLFNKPFDVLTQFNDEQGRSTLKDFIPVPGVYPAGRLDRDSEGLLLLTND 61

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G LQAR+  P  +  K Y+VQVEG P ++ L  LR GVTLNDGPTLPA A L+DEP  LW
Sbjct: 62  GRLQARIADPRHKLPKTYWVQVEGTPDEEQLRRLREGVTLNDGPTLPAEARLLDEPT-LW 120

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
            R PP+R RKS+PT WL++ + EGRNRQVRRMTA VG PTLRL+R  +G +SLD L  GE
Sbjct: 121 ERVPPVRFRKSVPTHWLELVIREGRNRQVRRMTAAVGLPTLRLVRVRIGPWSLDGLGLGE 180

Query: 212 WREV 215
           WREV
Sbjct: 181 WREV 184


>UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q1GHH2_SILST
          Length = 221

 Score =  234 bits (598), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 112/181 (61%), Positives = 142/181 (78%), Gaps = 4/181 (2%)

Query: 39  TRVILFNKPYDVLPQFTDEAG----RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGAL 94
           +R+I FNKP+DVLPQFTD       R TL +++   GVY AGRLDRDSEGL++LT+NG L
Sbjct: 2   SRLIRFNKPFDVLPQFTDRGSEGSPRATLSDYVDCPGVYPAGRLDRDSEGLMLLTDNGRL 61

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
           QA ++ P  +  K Y+VQVEGIPT+DAL+ALR GV L DG T PA AEL+ EPA LW R 
Sbjct: 62  QAWISDPKHKLEKTYWVQVEGIPTEDALKALRQGVDLKDGMTRPAKAELISEPAQLWART 121

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
           PPIRERKS+PT+WL++ + EG+NRQVRRMTA +G+PTLRLIRYA+G ++LD LA G+W +
Sbjct: 122 PPIRERKSVPTAWLELKISEGKNRQVRRMTAAMGYPTLRLIRYAIGAWTLDGLAQGKWDD 181

Query: 215 V 215
           +
Sbjct: 182 L 182


>UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae RepID=B3GZS7_ACTP7
          Length = 232

 Score =  218 bits (555), Expect = 1e-55,   Method: Compositional matrix adjust.
 Identities = 103/175 (58%), Positives = 126/175 (72%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           T V+LFNKP+DVL QFTDE GR+TLK+FIP+  +Y  GRLDRDSEGLL+LTNNG +Q RL
Sbjct: 40  TVVVLFNKPFDVLTQFTDEQGRQTLKDFIPIPQIYPVGRLDRDSEGLLLLTNNGEIQHRL 99

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K Y  QVEGIP    L  L  GV L DG T PA A+ +  P + W   P IR
Sbjct: 100 ANPKFEKQKTYLAQVEGIPQAADLAKLEKGVELKDGLTKPAKAKAISAPNYEWQTAPKIR 159

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           ERK+IPTSW+++ ++EG+NRQVRRMTAH+GFPTLRLIR  +G + L  L +GE+R
Sbjct: 160 ERKTIPTSWIELKIHEGKNRQVRRMTAHIGFPTLRLIRIGLGQFQLGELNSGEYR 214


>UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BDP6_9GAMM
          Length = 228

 Score =  217 bits (552), Expect = 3e-55,   Method: Compositional matrix adjust.
 Identities = 105/177 (59%), Positives = 134/177 (75%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +R +LFNKP+ VL QFTD   R+TL +FI V  VY+AGRLD DSEGLL+LT++GAL   +
Sbjct: 2   SRYLLFNKPFQVLTQFTDPDNRQTLADFIDVPEVYSAGRLDYDSEGLLLLTDDGALIHSM 61

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P  +T K Y  QVEG  T +A+  L +G+ L DGPTLPA A  V EPAWLWPR PPIR
Sbjct: 62  MNPRFKTPKTYLAQVEGDITDEAIRRLESGLQLKDGPTLPAKARRVSEPAWLWPRQPPIR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ER +IP SW+++TL EGRNRQVRRMTA VGFPTLRLIR A+ + ++++L+ G+++EV
Sbjct: 122 ERATIPASWVELTLVEGRNRQVRRMTAAVGFPTLRLIRVALAELTVESLSVGQYKEV 178


>UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testosteroni
           RepID=D0IWI1_COMTE
          Length = 223

 Score =  215 bits (548), Expect = 8e-55,   Method: Compositional matrix adjust.
 Identities = 111/201 (55%), Positives = 143/201 (71%), Gaps = 9/201 (4%)

Query: 24  FSSQRSTR-------RKPENQP--TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYA 74
           FSS RS+        R+P  +P  TR++ F+KPY VL QFT E   + LK++I V GVY 
Sbjct: 17  FSSNRSSNLRRSTVVRQPAPRPGVTRLLCFHKPYGVLSQFTPEGKWQGLKDWIDVPGVYV 76

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
           AGRLD DSEGLL+LTN+G LQAR+  P  +  K Y+VQVEGIP + AL+ LR GV L+DG
Sbjct: 77  AGRLDADSEGLLLLTNDGQLQARIADPRHKMEKTYWVQVEGIPDEAALQRLREGVELSDG 136

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
            TLPA A L++    +WPRNPPIR R++IP  W+++ + EGRNRQVRRMTA VG PTLRL
Sbjct: 137 KTLPAKARLIEPQPLMWPRNPPIRVRQNIPDCWIELIIREGRNRQVRRMTAAVGHPTLRL 196

Query: 195 IRYAMGDYSLDNLANGEWREV 215
           +R A+G YS++ L  G+W +V
Sbjct: 197 VRMAVGPYSIEGLEPGQWLDV 217


>UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumophila
           RepID=Q5ZXB8_LEGPH
          Length = 222

 Score =  209 bits (531), Expect = 7e-53,   Method: Compositional matrix adjust.
 Identities = 101/176 (57%), Positives = 128/176 (72%), Gaps = 1/176 (0%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ILFNKPY +L QFT E   +TL  FI + G YAAGRLD+ SEGLL+LT++G LQ RLT
Sbjct: 25  QLILFNKPYGILTQFTGELPEQTLSAFIKLPGFYAAGRLDKQSEGLLILTDDGKLQHRLT 84

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y+VQVEG+PT   L+ LR G+ + D   LPA A L+ EP  +WPR PPIRE
Sbjct: 85  HPKFEKKKHYWVQVEGVPTDKDLQPLRKGLVIKDITFLPAEARLISEPK-IWPRIPPIRE 143

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RK IPT+WL+I L EG+N Q+R+MTA +GFPTLRLIRY +GD+ LD L  GE++ +
Sbjct: 144 RKHIPTTWLEIILREGKNHQIRKMTAAIGFPTLRLIRYQIGDWHLDQLQPGEYKLI 199


>UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella drancourtii LLAP12
           RepID=C6MZI4_9GAMM
          Length = 240

 Score =  205 bits (521), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 102/175 (58%), Positives = 127/175 (72%), Gaps = 1/175 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           + +ILFNKP+ V+ QFT E    TL EFI     YAAGRLD++SEGLL+LTN+GALQ +L
Sbjct: 53  SELILFNKPFAVVCQFTGEKHEHTLAEFIDKPDFYAAGRLDKNSEGLLLLTNDGALQHQL 112

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K Y+VQVEGIPT   LE L+ G+ L D   LPA    ++EPA LWPR PP+R
Sbjct: 113 THPKFNKKKYYWVQVEGIPTAADLEPLKKGLVLKDITFLPAEVRCIEEPA-LWPRTPPVR 171

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
            R+SIPTSWL+I L EG+N QVRRMTA +GFPTLRL+R+ +GD+ L +L  GE+R
Sbjct: 172 FRQSIPTSWLEIILREGKNHQVRRMTAAMGFPTLRLVRHRIGDWQLGDLQPGEFR 226


>UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E n=26 Tax=Bacteria
           RepID=Q1QUR9_CHRSD
          Length = 257

 Score =  204 bits (520), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 103/178 (57%), Positives = 128/178 (71%), Gaps = 1/178 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           + + L +KPY +L QFTD  GR TL E I V  +Y AGRLD DSEGLL+LT +GAL  R+
Sbjct: 60  SSLYLLHKPYQMLSQFTDTRGRATLAEAIDVPDIYPAGRLDYDSEGLLLLTGDGALAHRI 119

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           + P  +  K Y+VQVEG P   AL+ALR GVTL DGPT PA    ++ P  + PR+PP+R
Sbjct: 120 SHPRHKQPKTYWVQVEGEPEPAALQALRQGVTLRDGPTRPAKVRRLESPD-VAPRHPPVR 178

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            R+++PT+WL++TL EGRNRQVRRMTAHVG PTLRLIR A+G + L  LA GEWR  T
Sbjct: 179 HREAVPTAWLELTLSEGRNRQVRRMTAHVGHPTLRLIRVAIGSWHLAGLAPGEWRRET 236


>UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=A3YG85_9GAMM
          Length = 242

 Score =  196 bits (498), Expect = 5e-49,   Method: Compositional matrix adjust.
 Identities = 101/176 (57%), Positives = 125/176 (71%), Gaps = 5/176 (2%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +I+FNKP+ VL QFT +  + TL  FI     Y AGRLD DSEGLL+LT++GALQ  +  
Sbjct: 4   IIVFNKPFQVLSQFTTDEEKATLSSFIDKANFYPAGRLDYDSEGLLLLTDHGALQHLIAS 63

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVD--EPAWLWPRNPPIR 158
           P  +  K Y VQVEG  T++A+E LR GV L DG T PA A++    EP   WPR+PPIR
Sbjct: 64  PQHKMPKTYLVQVEGELTKEAVEQLRVGVELKDGLTKPAEAKIASDFEP---WPRHPPIR 120

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
           ERK+IPTSWL++T+ EG+NRQVRRMTA VGFPTLRLIR  +G YSL ++  G W E
Sbjct: 121 ERKNIPTSWLELTITEGKNRQVRRMTAAVGFPTLRLIRTQIGPYSLTDIELGHWLE 176


>UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q6FCZ3_ACIAD
          Length = 264

 Score =  195 bits (496), Expect = 8e-49,   Method: Compositional matrix adjust.
 Identities = 99/178 (55%), Positives = 125/178 (70%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++FNKPYDVL QF +++   T+  FI    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVVFNKPYDVLSQFREDSAHLTVSSFIADPELRIAGRLDLDSEGLMFLTDHGGLNQYIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T+DALE LR GV L DG TLPA A  V+EP WLW RNPP+R 
Sbjct: 62  HPSNKKYKTYLVQVDGDITEDALEKLRKGVELADGLTLPAQATKVEEPEWLWERNPPVRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA--NGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMTA VGFPTLRLIR  +G  +L  L    GE +E+
Sbjct: 122 RASIPTSWVEISICEGRNRQVRRMTATVGFPTLRLIRTQIGSINLVKLGLQPGEQKEI 179


>UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter RepID=A3M7K0_ACIBT
          Length = 262

 Score =  189 bits (479), Expect = 7e-47,   Method: Compositional matrix adjust.
 Identities = 95/178 (53%), Positives = 122/178 (68%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++ NKPYDVL QF  +    T+ +F+    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVILNKPYDVLSQFRKDEAHMTVSDFVDDPTLRIAGRLDMDSEGLVFLTDHGGLNQFIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T++ALE LR GV LNDG TLPA A  V EP WLW R+PP+R 
Sbjct: 62  NPANKKYKTYLVQVDGDVTEEALEQLRKGVELNDGMTLPAKAIKVSEPEWLWDRDPPVRY 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA--NGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMT+ VGFPTLRLIR  +G   L  L    GE +E+
Sbjct: 122 RASIPTSWIEISICEGRNRQVRRMTSAVGFPTLRLIRTKIGTIDLVQLGLQPGETKEI 179


>UniRef50_Q4FV02 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q4FV02_PSYA2
          Length = 208

 Score =  185 bits (469), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 97/188 (51%), Positives = 125/188 (66%), Gaps = 14/188 (7%)

Query: 39  TRVILFNKPYDVLPQFTDEAG--RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           + +ILFNKPY V  QF D++     TL E+   + +  AGRLD  SEGLL+LT++G +  
Sbjct: 4   SSLILFNKPYGVQSQFRDDSNNDHTTLSEYFTDKSLRIAGRLDATSEGLLILTSDGRINK 63

Query: 97  RLTQP---------GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE- 146
            +TQP          ++ GK Y VQVEG+ T   L+ L +GV L DG TLPA A L+DE 
Sbjct: 64  AITQPPSAKNFAQNKQKQGKTYLVQVEGVVTAVQLKELASGVILKDGKTLPASATLLDEA 123

Query: 147 --PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
             P  LW R+PPIRERK+IPTSWL +T+YEG+NRQVRRMTAHVG P LRLIR+++  + L
Sbjct: 124 DLPITLWQRDPPIRERKNIPTSWLMLTIYEGKNRQVRRMTAHVGLPCLRLIRWSVAGFEL 183

Query: 205 DNLANGEW 212
             L  GE+
Sbjct: 184 GELGVGEF 191


>UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q2JQ37_SYNJB
          Length = 226

 Score =  184 bits (468), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 101/178 (56%), Positives = 128/178 (71%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           R + F KPY VL QFTD  GR TL+ FIPV  VY  GRLDRDSEGLL+LT++G L ARL 
Sbjct: 29  RYLKFYKPYGVLTQFTDREGRPTLQSFIPVPRVYPVGRLDRDSEGLLLLTDDGRLNARLI 88

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     +IY+VQVEGIPT  AL+ L+ G+ +    T PA  +++ E   L PR+PPIR 
Sbjct: 89  DPKFGHERIYWVQVEGIPTPQALQQLQQGLIIQGRKTRPAQVKVLAEEPTLPPRDPPIRF 148

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R+SIPT+WL++TL EGRNRQVRRMTA VG PTLRL+R  +G  SL  LA G+W+++++
Sbjct: 149 RRSIPTTWLELTLREGRNRQVRRMTAAVGIPTLRLVRVGLGPLSLAGLAPGQWQDLSE 206


>UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr0612 n=16
           Tax=Bacteria RepID=Y612_SYNY3
          Length = 261

 Score =  181 bits (458), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 103/200 (51%), Positives = 128/200 (64%), Gaps = 20/200 (10%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAG--RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
           N+  + I+F KPY VL QFTD +   R TLK++I +  +Y  GRLD+DSEGLL+LT+NG 
Sbjct: 36  NKTPQTIVFYKPYGVLCQFTDNSAHPRPTLKDYINLPDLYPVGRLDQDSEGLLLLTSNGK 95

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           LQ RL        + Y+ QVEG PT + LE LR G+T  D PT PA A+++ EP +  PR
Sbjct: 96  LQHRLAHREFAHQRTYFAQVEGSPTDEDLEPLRRGITFADYPTRPAIAKIITEPDFP-PR 154

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY---------------- 197
           NPPIR R SIPTSWL ITL EGRNRQVRRMTA VGFPTLRL+R                 
Sbjct: 155 NPPIRYRASIPTSWLSITLTEGRNRQVRRMTAAVGFPTLRLVRVQIQVTGRSPQQGKGKS 214

Query: 198 -AMGDYSLDNLANGEWREVT 216
            A    +L+ L+ G+WR +T
Sbjct: 215 AATWCLTLEGLSPGQWRPLT 234


>UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XK09_SYNP2
          Length = 223

 Score =  177 bits (449), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 95/183 (51%), Positives = 122/183 (66%), Gaps = 8/183 (4%)

Query: 42  ILFNKPYDVLPQFTDEA----GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           +L +KPY+VL QFTD +     R+TLK+F+PV  +Y+ GRLD DSEGLL+LTN+  L+  
Sbjct: 6   VLLHKPYNVLCQFTDNSPQGSQRQTLKDFVPVPDIYSVGRLDLDSEGLLLLTNDAPLKHY 65

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           L +P     + Y+VQVE IP   ALE LR GV +    T PA A L+     +  R PPI
Sbjct: 66  LCEPKFAHSRTYWVQVENIPDGQALEQLRQGVMVQGKKTRPAIANLLTPEPTVPAREPPI 125

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG----DYSLDNLANGEWR 213
           R RK++PT+WL++TL EGRNRQVRRMTA VG PTLRL+R A+G      +L  L  GEWR
Sbjct: 126 RFRKNVPTAWLELTLTEGRNRQVRRMTAAVGHPTLRLMRVAIGAGPAKLTLTGLGPGEWR 185

Query: 214 EVT 216
            +T
Sbjct: 186 HLT 188


>UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales RepID=A2S4Y2_BURM9
          Length = 235

 Score =  176 bits (447), Expect = 4e-43,   Method: Compositional matrix adjust.
 Identities = 101/212 (47%), Positives = 133/212 (62%), Gaps = 8/212 (3%)

Query: 12  QKT--SFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           QKT  S    ++  F+ +R  RR      E  P R+I  NKP+  + QF+    R +L +
Sbjct: 11  QKTRRSVLCIKIPPFAIERGPRRAAPLPREPCPMRLIALNKPFGTICQFSAHETRASLGD 70

Query: 66  FIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL 125
           ++   GVY AGRLD DSEGLL+LT++GALQA++ +P  +  K Y+ QVEG P   AL AL
Sbjct: 71  WVKTPGVYPAGRLDADSEGLLLLTDDGALQAKIAEPRHKLVKRYWAQVEGAPDAAALAAL 130

Query: 126 RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTA 185
             GV L D  + P  A  +  P  LWPRNPPIR R +IPT+W+++ + EG+NRQVRRMTA
Sbjct: 131 ERGVDLGDYVSRPCRARFITPPGALWPRNPPIRHRAAIPTAWIELEIAEGKNRQVRRMTA 190

Query: 186 HVGFPTLRLIRYAMG--DYSLDNLANGEWREV 215
            VGFPTLRL+R  +G  D     LA GE RE+
Sbjct: 191 AVGFPTLRLVRVGIGALDVFALGLAPGETREL 222


>UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E n=1 Tax=Cyanobium
           sp. PCC 7001 RepID=B5INL2_9CHRO
          Length = 243

 Score =  173 bits (439), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 103/193 (53%), Positives = 125/193 (64%), Gaps = 12/193 (6%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNN 91
           P ++PT  +LF+KPY VL QFT E G +   L +FI V GVYAAGRLD DSEGLL+LT N
Sbjct: 9   PASRPT-TLLFHKPYGVLSQFTPEPGSRWRCLADFIAVPGVYAAGRLDADSEGLLLLTAN 67

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQ--DALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           G LQ RLT P     + Y+VQVEG   Q  +AL+ LR GV +    T PA    + +P  
Sbjct: 68  GRLQQRLTDPAFGHWRTYWVQVEGEAGQRPEALQQLRQGVVIQGRLTRPALVRCLSDPK- 126

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM------GDYS 203
           L  R+PPIR+R +IP SWL++ L EGRNRQVRRMTA VG PTLRLIR A+         S
Sbjct: 127 LPERDPPIRQRATIPVSWLELQLQEGRNRQVRRMTARVGLPTLRLIRVAIDLMDGEAPLS 186

Query: 204 LDNLANGEWREVT 216
           L  L  G+WR V+
Sbjct: 187 LSGLKPGDWRRVS 199


>UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria RepID=A0Z1Z6_9GAMM
          Length = 208

 Score =  169 bits (428), Expect = 6e-41,   Method: Compositional matrix adjust.
 Identities = 88/175 (50%), Positives = 115/175 (65%), Gaps = 4/175 (2%)

Query: 41  VILFNKPYDVLPQFTD---EAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           +IL NKP+ VL QF+D   +  R TL   +       AGRLD DSEGL +LT++G LQ +
Sbjct: 26  IILLNKPFRVLSQFSDRDNDPPRLTLANLLSAPEFRVAGRLDYDSEGLTLLTDDGKLQQQ 85

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           +  P  +  K Y+VQVEG P Q A+E L +GV LNDG T PA    +D P  LW R+P +
Sbjct: 86  IANPKFKVWKTYWVQVEGAPKQQAIEQLTSGVVLNDGLTKPAKVRAIDPPD-LWERSPSV 144

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           R R  IP +WL+I++ EGRNRQ+RRMTA V  PTLRL+R A+GD+ + NL  GE+
Sbjct: 145 RFRAHIPDAWLEISIQEGRNRQIRRMTAAVNLPTLRLVRIAIGDWEIGNLQPGEY 199


>UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1ZYI5_OPITP
          Length = 188

 Score =  168 bits (425), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 89/178 (50%), Positives = 114/178 (64%), Gaps = 2/178 (1%)

Query: 41  VILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +   +KPY VL QFT E G +  TL EF     VY  GRLD DSEGLL+L++   L  RL
Sbjct: 2   LCALHKPYGVLSQFTPEPGSRWRTLAEFGLPPAVYPLGRLDADSEGLLLLSDEPGLNTRL 61

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P +   + Y+VQVE +PT  AL  L+ GV + D  T P  A  +D    L PR+PPIR
Sbjct: 62  LNPDQAHRREYWVQVERVPTDAALAQLQRGVKIGDYATRPCAARRLDPAPTLPPRDPPIR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            RK++P  WL + L EG+NRQVRRMTA +G PTLRL+R  +GD++L  LA G+WRE+T
Sbjct: 122 ARKNVPDCWLALELIEGKNRQVRRMTAAIGHPTLRLVRVRIGDFALGKLAVGQWRELT 179


>UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2ULL1_AKKM8
          Length = 188

 Score =  164 bits (416), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 89/177 (50%), Positives = 115/177 (64%), Gaps = 2/177 (1%)

Query: 41  VILFNKPYDVLPQFTDEA-GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ FNKPY +L QFT EA   +TL EF    GVY  GRLD DSEGLL+L++   L  RL 
Sbjct: 2   ILAFNKPYGILSQFTKEAPHHRTLAEFGFPPGVYPVGRLDADSEGLLLLSDEKGLADRLL 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALR-NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P  R  + Y+ QVEG P++  L  L   G+ +    TLP  A L+     + PR PP+R
Sbjct: 62  NPSGRHPRTYWSQVEGTPSETDLRPLELGGLRIRGHCTLPCRARLMRREPDVPPRIPPVR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            R SIPTSWL++TL EG+NRQVRRMTA +GFPTLRL+R  +G++SL  L  G W+E+
Sbjct: 122 YRASIPTSWLELTLVEGKNRQVRRMTAAIGFPTLRLLRARIGNFSLAGLKPGAWKEL 178


>UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=B2T6J8_BURPP
          Length = 189

 Score =  161 bits (407), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 81/168 (48%), Positives = 111/168 (66%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
            ++  NKP+  + QF+    R +L +++ V  VY AGRLD DSEGLL+LT++GALQAR+ 
Sbjct: 2   HLLALNKPFGTICQFSPHETRASLADWVKVPDVYPAGRLDSDSEGLLLLTDDGALQARIA 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           +P  +  K Y+ QVEG      L+ L  GV L D  T P  AE V+    LW R PPIR 
Sbjct: 62  EPRHKLVKRYWAQVEGAVDAATLKKLARGVDLGDYVTRPCRAEYVEPTDALWTRTPPIRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNL 207
           R +IPT+W+++++ EG+NRQVRRMTA VGFPTLRL+R  +G   + +L
Sbjct: 122 RAAIPTTWIELSITEGKNRQVRRMTAAVGFPTLRLVRVGIGALDIFSL 169


>UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=Q3AI58_SYNSC
          Length = 230

 Score =  160 bits (406), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 95/187 (50%), Positives = 115/187 (61%), Gaps = 12/187 (6%)

Query: 41  VILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
            +L NKPY VL QFT E G +   L +F+ V  VYAAGRLD DSEGLL+LT+NG LQ RL
Sbjct: 18  TLLLNKPYGVLSQFTSEEGSRWRCLSDFVDVPQVYAAGRLDADSEGLLILTSNGRLQQRL 77

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV---DEPAWLWPRNP 155
           T P     + Y+ QVEG P  + L+ L +GV +    TLPA A  +   D P  L  R P
Sbjct: 78  TDPRFGHWRSYWAQVEGTPNTEQLQQLCDGVVVQGRRTLPAKARWLQGQDLPQ-LPERTP 136

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG------DYSLDNLAN 209
            IR R +IPT+WL+++L EGRNRQVRRMTA VG PTLRL+R  +          L  L  
Sbjct: 137 QIRFRAAIPTNWLQLSLSEGRNRQVRRMTAAVGLPTLRLVRCCIDLMDNGPPLDLTGLQP 196

Query: 210 GEWREVT 216
           G WR VT
Sbjct: 197 GSWRTVT 203


>UniRef50_C6W5I1 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W5I1_DYAFD
          Length = 201

 Score =  155 bits (393), Expect = 8e-37,   Method: Compositional matrix adjust.
 Identities = 86/169 (50%), Positives = 112/169 (66%), Gaps = 7/169 (4%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKE--FIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
            L  KP+++L QF+ E   +TL +  F   + +Y  GRLD DSEGLL+LTN+  L+ +L 
Sbjct: 5   FLIYKPFNMLSQFSREGDHQTLADLGFTFAKDIYPVGRLDADSEGLLLLTNDNFLKTKLL 64

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG----PTLPAGAELVDEPAWLWPRNP 155
           +P  R  + YYVQVEG  T +A   L  GV+++       TLPA    + EP  L  RNP
Sbjct: 65  EPRNRHTRTYYVQVEGEVTDEACRQLSAGVSISINGKQYKTLPAEIAKIAEPE-LPERNP 123

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
           PIR RK+IPTSWL +TL EG+NRQVRRMTA VGFPTLRL+R+++G  SL
Sbjct: 124 PIRFRKNIPTSWLSVTLREGKNRQVRRMTAAVGFPTLRLVRWSIGKISL 172


>UniRef50_A5GM98 Pseudouridine synthase n=3 Tax=Synechococcus RepID=A5GM98_SYNPW
          Length = 171

 Score =  147 bits (370), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 84/152 (55%), Positives = 99/152 (65%), Gaps = 8/152 (5%)

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +YAAGRLD DSEGLL+LT NG LQ RLT P     + Y+VQVEG+     L AL  GV +
Sbjct: 1   MYAAGRLDADSEGLLILTENGRLQQRLTDPRFGHWRTYWVQVEGLADHGHLAALEQGVVI 60

Query: 132 NDGPTLPAGAELVDEPAW--LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
               T PA A  +D   W  L  R PPIRER++IPTSWL I+L EGRNRQ+RRMTA VG 
Sbjct: 61  KGQRTRPARATSLDSSFWFDLPERTPPIRERRTIPTSWLSISLREGRNRQIRRMTAAVGL 120

Query: 190 PTLRLIRYAMG------DYSLDNLANGEWREV 215
           PTLRLIR ++         SL+ LA G+WR V
Sbjct: 121 PTLRLIRRSIDLMDGGPPLSLEGLAPGQWRPV 152


>UniRef50_C8PVP6 RNA pseudouridine synthase family protein n=1 Tax=Enhydrobacter
           aerosaccus SK60 RepID=C8PVP6_9GAMM
          Length = 234

 Score =  147 bits (370), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 85/185 (45%), Positives = 110/185 (59%), Gaps = 12/185 (6%)

Query: 41  VILFNKPYDVLPQF--TDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +ILFNKPY VL QF   D     TL ++   + +  AGRLD  SEGLL+LT +G +   L
Sbjct: 4   LILFNKPYGVLSQFRSDDNNNFATLSDYFTDKSLRVAGRLDATSEGLLLLTADGQVNKAL 63

Query: 99  TQP-----GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEP---AWL 150
           T P     GK+ GK Y++QVEG  +   L+ L+ GV L DG TLPA    + E      +
Sbjct: 64  THPPKANAGKQQGKTYWIQVEGDASDAQLQQLQTGVPLKDGITLPAEVVRLSEAQIAEHI 123

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
           W  +  I +RK   T+WL IT++EG+NRQVRRM AHVG P LRLIR A   +SL NL  G
Sbjct: 124 WQASDKIAKRKV--TTWLAITIFEGKNRQVRRMAAHVGLPCLRLIRMASSGFSLGNLEVG 181

Query: 211 EWREV 215
              ++
Sbjct: 182 ASTQI 186


>UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=A4J3M3_DESRM
          Length = 309

 Score =  129 bits (323), Expect = 9e-29,   Method: Compositional matrix adjust.
 Identities = 72/177 (40%), Positives = 98/177 (55%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L NKP   +   +DE  RKT+ + +    Q VY  GRLD DSEGLL+LTN+G L   LT
Sbjct: 66  LLMNKPRGYVTTLSDERDRKTVVDLLKGVEQRVYPVGRLDYDSEGLLLLTNDGELTQALT 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y  +V+GIP  + L+A+  G+ L DGPT PA   L                
Sbjct: 126 HPKHKVKKTYLAKVDGIPETEELKAMAKGLVLEDGPTAPADVRLAGTGDN---------- 175

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                 + L+I+++EGRNRQVRRM  H+G+  LRL R  +G   L +L +GE R +T
Sbjct: 176 -----RALLEISIHEGRNRQVRRMCEHIGYKVLRLRRTRIGTLELGSLKSGEVRALT 227


>UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibacillus larvae subsp. larvae
           BRL-230010 RepID=UPI0001693918
          Length = 249

 Score =  127 bits (320), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 75/184 (40%), Positives = 99/184 (53%), Gaps = 15/184 (8%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLT 89
           R  +NQ    ILFNKP  V+   +D  GR+ + +F+    + VY  GRLD D+EGLL+LT
Sbjct: 55  RAIQNQEKIYILFNKPKGVITSVSDPEGRRVVGDFLKGIKERVYPVGRLDYDTEGLLILT 114

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           N+G     +T P     K Y+  V+G+P    LE LR GV L DG T PA  E  D    
Sbjct: 115 NDGEFANMVTHPRHHVSKTYHATVKGVPHGSVLEKLREGVKLEDGMTAPAEVEYHD---- 170

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
               +P  ++      S + IT+YEG+NRQVRRM   VG+P  RL R   G   L  L  
Sbjct: 171 ---IDPDKKQ------SVISITIYEGKNRQVRRMFEAVGYPVTRLKRVKFGSIPLVGLPR 221

Query: 210 GEWR 213
           G++R
Sbjct: 222 GKFR 225


>UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CFA0_THET1
          Length = 253

 Score =  125 bits (315), Expect = 8e-28,   Method: Compositional matrix adjust.
 Identities = 79/183 (43%), Positives = 103/183 (56%), Gaps = 17/183 (9%)

Query: 37  QP-TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGAL 94
           QP  R IL NKP  VL    DE GRKT+ + +     VY  GRLD+DSEGL++LTN+G L
Sbjct: 61  QPKMRYILLNKPAGVLSTAKDERGRKTVIDLLGQSNRVYPVGRLDKDSEGLMLLTNDGEL 120

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             R+T P     K Y V+VEG  +  +L+ L  GV L DG + P  A+++          
Sbjct: 121 AQRITHPRYGVHKQYMVEVEGYFSDRSLQDLLQGVELEDGFSKPLDAKIIS--------- 171

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                 +S   S L IT+ EGR RQVRR  A +G+   RL R A+G  SL NL  GE+RE
Sbjct: 172 ------RSRDKSKLLITMGEGRKRQVRRTLAALGYKVKRLTRVALGPLSLGNLKPGEYRE 225

Query: 215 VTD 217
           ++D
Sbjct: 226 LSD 228


>UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=C8WXC0_ALIAD
          Length = 273

 Score =  124 bits (310), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 72/183 (39%), Positives = 99/183 (54%), Gaps = 15/183 (8%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGA 93
            QP  V++ NKP   L   +D  GR+T+ + +P   + VY  GRLD D+ GLL+ TN+G 
Sbjct: 59  EQPV-VLVLNKPVAYLSTVSDPLGRRTVMQLLPPIRERVYPVGRLDYDTSGLLLFTNDGE 117

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  RL  P +   K+Y V V GI  ++   AL  GV L DG T PA  E++ +       
Sbjct: 118 LTQRLLHPSREIEKVYRVSVRGIVDRETRRALMEGVELEDGVTAPAKVEVLRQAD----- 172

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                  +    + + + ++EGRNRQVRRM   +G P LRL R A G  SL +L  GEWR
Sbjct: 173 -------REDGVAVVHLAIHEGRNRQVRRMFERLGLPVLRLKRIAFGPVSLGHLKTGEWR 225

Query: 214 EVT 216
            +T
Sbjct: 226 ALT 228


>UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus marinus
           RepID=Q7VBH8_PROMA
          Length = 237

 Score =  121 bits (304), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 65/188 (34%), Positives = 103/188 (54%), Gaps = 19/188 (10%)

Query: 34  PEN-QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLT 89
           P+N + ++VIL NKP  V+    D  GRKT+ + +P    +G++  GRLD+DS G L+++
Sbjct: 57  PKNIKSSKVILLNKPTGVISTCRDTHGRKTVLDLLPDNLQKGMHPVGRLDKDSRGALIIS 116

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           NNG L   LT P     K Y V + G+P+++ L+  RNG+ ++   T  A   +V     
Sbjct: 117 NNGLLTLHLTHPRFNHKKRYSVLITGVPSKNTLKKWRNGIEIDKKTTRKALVNIVKRQG- 175

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                           + L+I L+EGRNRQ+R++   +G P + LIR  +G+  L+ L  
Sbjct: 176 --------------NNTLLEIVLFEGRNRQIRKVADKLGHPVIDLIRIEIGNIKLNGLKE 221

Query: 210 GEWREVTD 217
           G WRE+ +
Sbjct: 222 GAWREINE 229


>UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YJH7_THEYD
          Length = 237

 Score =  120 bits (301), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 72/188 (38%), Positives = 100/188 (53%), Gaps = 23/188 (12%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV----YAAGRLDRDSEGLLVL 88
           KPE  P     F KP  V+    D  GR T+++FI  +G+    Y  GRLD DSEGLL+L
Sbjct: 58  KPE--PKVYYAFYKPRKVITALLDPQGRPTIRDFI--KGIKFRIYPVGRLDFDSEGLLLL 113

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN+G L  ++  P  +  K Y V+V+GI   + +E LR G+ +     +P    LV    
Sbjct: 114 TNDGELAYKVMHPSSQIEKTYMVKVDGIVEPETIEKLRKGIKIEGKLAVPVSVHLV---- 169

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                      +K    SW+KITL+EGR RQ+R+M   VG P +RLIR A+    L +L 
Sbjct: 170 -----------KKLKANSWIKITLHEGRKRQIRKMLERVGHPVIRLIRIAIDGVKLGDLK 218

Query: 209 NGEWREVT 216
            G+ R +T
Sbjct: 219 PGQLRPLT 226


>UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium RepID=C6JI84_FUSVA
          Length = 236

 Score =  119 bits (298), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 67/176 (38%), Positives = 100/176 (56%), Gaps = 16/176 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           + NKP +VL    D+ GRKT+ + I  +  ++  GRLD ++ GL++LTN+G L  R+  P
Sbjct: 67  ILNKPLEVLSSSKDDRGRKTVVDLINCKERIFPIGRLDYNTSGLIILTNDGELFNRIIHP 126

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
                K YYV+V G   ++ +E L+NGV L+DG TLPA   ++               R+
Sbjct: 127 KAEIFKEYYVKVLGEIKENNVELLKNGVELDDGITLPANVRIL---------------RR 171

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
               + L + + EGRNRQVRRM   +  P + L R  +G+ SL NL  GE+RE+T+
Sbjct: 172 EKGKTELLVAIREGRNRQVRRMMDKINHPVITLRREKIGNLSLGNLKLGEYRELTN 227


>UniRef50_A3QB38 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3QB38_SHELP
          Length = 182

 Score =  118 bits (295), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 75/181 (41%), Positives = 101/181 (55%), Gaps = 9/181 (4%)

Query: 43  LFNKPYDVLPQFTDEAGRKT--LKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +  KPY  L QF  E  ++   L E      G+ A GRLD DSEGLL+LT +G     + 
Sbjct: 1   MIFKPYGYLSQFVGERRKRKPLLGELANFPTGIMAIGRLDHDSEGLLLLTTDGKTSHAVR 60

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP----TLPAGAELVDEPAWLWPRNP 155
              K   K YY+Q++G  T+ A+ +L  GV +        TLP  A  +D+   L PR  
Sbjct: 61  S--KSIEKEYYLQLDGEITEQAISSLCEGVEIGIKGEKYRTLPCRARRLDQAPDLPPRGR 118

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            IR+ +  PTSWL IT+ EG+NRQ+R+MTA VGF TLRL+R  +GD  L  L  GE + +
Sbjct: 119 KIRDARHGPTSWLAITITEGKNRQLRKMTAAVGFATLRLVRVRIGDIRLGTLQPGEVKSL 178

Query: 216 T 216
            
Sbjct: 179 A 179


>UniRef50_A6BL18 Pseudouridine synthase Rsu (Fragment) n=1 Tax=Leptolyngbya
           valderiana BDU 20041 RepID=A6BL18_9CYAN
          Length = 152

 Score =  118 bits (295), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 61/122 (50%), Positives = 83/122 (68%)

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
           Q RL  P     + Y+VQVE +P + +L+ LR+GVT+    T PA    +     L PR+
Sbjct: 2   QHRLLDPKFGKSRAYWVQVERVPDEASLQRLRDGVTIRQYRTRPARVRRLAIAPDLPPRH 61

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
           PPIR RK++PT WL+++L EGRNRQVRRMTA VG PTLRL+R A+ + +LD L  G+WR+
Sbjct: 62  PPIRFRKNVPTCWLEMSLTEGRNRQVRRMTAAVGHPTLRLVRVAVENLTLDALQPGQWRD 121

Query: 215 VT 216
           +T
Sbjct: 122 LT 123


>UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C4P7_9PLAN
          Length = 352

 Score =  117 bits (292), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 65/183 (35%), Positives = 101/183 (55%), Gaps = 17/183 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGAL 94
           QP R  L NKP   L    D AGR+ + +  P  G  ++  GRLD +SEGL+++TN+G L
Sbjct: 80  QPRRYYLLNKPSGFLCTNNDPAGRRRVVDLFPNDGQRLFTVGRLDENSEGLILVTNDGEL 139

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             RL  P  R  + Y+VQV G P ++ L+ LR GV   +G    +G + +          
Sbjct: 140 AQRLAHPRYRVARTYHVQVVGNPPREKLDELRKGVRFKEGVFRVSGLKYL---------- 189

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                +K   +++L++TL+EG+NR++RRM A +G   ++L+R   G  +L  L  GE R 
Sbjct: 190 -----KKQGKSAFLELTLHEGQNREIRRMMARIGHKVIQLVRIRFGPLNLGKLKTGESRR 244

Query: 215 VTD 217
           ++D
Sbjct: 245 LSD 247


>UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepID=B9E1X9_CLOK1
          Length = 245

 Score =  115 bits (289), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 60/177 (33%), Positives = 94/177 (53%), Gaps = 16/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           IL NKP   +    D+ GRKTL + + V + VY  GRLD ++ G ++LTN+G +   +  
Sbjct: 72  ILLNKPRGYISSVKDDRGRKTLLDIVKVNERVYPIGRLDYNTSGAIILTNDGEVYNNIAH 131

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           PG    KIY   ++GIP+ + ++   NG+ +    T  A  + +                
Sbjct: 132 PGSNKSKIYIAAIKGIPSSEEIKRFENGIDIGGYITAKAKFDFISSNK------------ 179

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
               +S +KI ++EG+NRQVR+M   +G P + L+R A+GD  L NL  G WR +T+
Sbjct: 180 ---ESSKVKIEIHEGKNRQVRKMCDAIGHPVITLMRIAIGDIKLGNLKEGAWRYLTE 233


>UniRef50_A4BXB5 Pseudouridine synthase n=2 Tax=Bacteroidetes RepID=A4BXB5_9FLAO
          Length = 181

 Score =  115 bits (288), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 76/180 (42%), Positives = 103/180 (57%), Gaps = 10/180 (5%)

Query: 43  LFNKPYDVLPQFTDEAGRKT--LKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + +KP+ ++ QF + A RK   L +     +G  A GRLD  SEGLL+LT +G + A + 
Sbjct: 1   MVHKPWGMISQFVNPAKRKKTLLGDLYGFPEGTMAIGRLDVPSEGLLLLTTDGKVSAEIR 60

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN----DGPTLPAGAELVDEPAWLWPRNP 155
                  K YYVQV+GI T  ALE L+ GV +        T P  A L+ +P +   R+ 
Sbjct: 61  SNAYE--KEYYVQVDGIMTAAALENLKTGVEIGFKGTKYVTKPGKAMLLKDPRFPL-RSQ 117

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            IR+ +  PTSW+ I + EG+ RQVR+MTA VGFPTLRL+R  +G   L  LA G   EV
Sbjct: 118 KIRDERHGPTSWISIIIKEGKFRQVRKMTAAVGFPTLRLVRVRIGTMKLGELAIGAVVEV 177


>UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3U4L2_9BACT
          Length = 420

 Score =  114 bits (285), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 69/185 (37%), Positives = 99/185 (53%), Gaps = 21/185 (11%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV----YAAGRLDRDSEGLLVLTNNG 92
           QP   ++ NKP +V+    D  GR T+K+ +   GV    +  GRLD DSEGL++LTN+G
Sbjct: 61  QPYVYLILNKPKNVMSTLDDPEGRPTVKDLL--HGVTVRVFPVGRLDFDSEGLMLLTNHG 118

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L   L  P     K Y ++V+G+     +EAL  GV L DG T PA  + V        
Sbjct: 119 DLAQALLHPRYHVPKTYLIKVKGVLDDAKIEALERGVKLEDGFTAPAKVKKVS------- 171

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                   ++   SWL++T++EGR  QV+RM   VG   ++L+R  MG   L +LA  E+
Sbjct: 172 --------RAESNSWLEVTIHEGRKHQVKRMVEAVGHSVIKLVRVRMGPLLLGDLAPREY 223

Query: 213 REVTD 217
           R +TD
Sbjct: 224 RFLTD 228


>UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=B2A4P2_NATTJ
          Length = 238

 Score =  113 bits (283), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 67/176 (38%), Positives = 94/176 (53%), Gaps = 18/176 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           I+ NKP D +    D  GRKT+ + I V+  VY  GRLD DS GL++LTN+G L  RL  
Sbjct: 64  IMLNKPKDYITSKDDPQGRKTVMDLIQVKERVYPVGRLDYDSRGLVLLTNDGELANRLMH 123

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y V+V+ +P QD L+ L NG+ L +G       E++D               
Sbjct: 124 PKYNIPKTYMVKVDKLPLQDKLDNLVNGIYLEEGLCKADHVEILD--------------- 168

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                + LKI L EGR RQ+RRM A +G     L R ++G  +L +L+ G +R++T
Sbjct: 169 --TKNNILKIILSEGRKRQIRRMLASLGIEVKDLKRDSLGTLTLKDLSEGNYRKLT 222


>UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria RepID=Q3AVD5_SYNS9
          Length = 247

 Score =  113 bits (283), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 72/182 (39%), Positives = 96/182 (52%), Gaps = 18/182 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGA 93
           Q  RV L NKP  V+    D  GR T+ + +P Q   G++  GRLD DS G L+LT+ G 
Sbjct: 61  QEPRVFLLNKPVGVICSCRDPQGRATVLDCLPHQERSGLHPVGRLDADSRGALLLTDQGE 120

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  RLT P     K Y V V GIP+  AL   R+G+ L+   T PA             R
Sbjct: 121 LTLRLTHPRYNHAKTYRVLVRGIPSSQALRRWRDGLLLDGRLTRPA-------------R 167

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
              +R R +  +S L++ L EGRNRQ+RR+   +G P + L R A+    LD+LA G WR
Sbjct: 168 VHCLRSRGA--SSLLEVELKEGRNRQIRRVAELLGHPVIDLQRVAIDGIRLDDLAEGCWR 225

Query: 214 EV 215
            +
Sbjct: 226 RL 227


>UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L6G3_MAGSM
          Length = 332

 Score =  112 bits (280), Expect = 8e-24,   Method: Compositional matrix adjust.
 Identities = 71/187 (37%), Positives = 97/187 (51%), Gaps = 17/187 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTN 90
           P+      I+ +KP  ++   +D  GR+T+ + I   G   +   GRLD +SEGL++LT+
Sbjct: 125 PQRSRDTAIILHKPKSIICTRSDPQGRRTIFDLIENHGSSRLITVGRLDINSEGLIILTS 184

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRN-GVTLNDGPTLPAGAELVDEPAW 149
           +G L   L  P +   ++Y V+  GI     LE +R  GV L DGPT P   E+V +   
Sbjct: 185 DGQLAHGLMHPSREVPRVYRVKTHGILLASQLEQIRTVGVRLEDGPTGPL--EIVLD--- 239

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                   R R+    SW  ITL EGRNR+VRR+  H G    RL+R   G  SL NL  
Sbjct: 240 --------RGREQGNNSWYTITLREGRNREVRRIFDHFGLQVARLLRVGYGGISLGNLEP 291

Query: 210 GEWREVT 216
           G WR VT
Sbjct: 292 GAWRPVT 298


>UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WGQ8_EGGLE
          Length = 282

 Score =  111 bits (278), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 68/193 (35%), Positives = 100/193 (51%), Gaps = 19/193 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARL 98
           I+ +KP   +   +D  GR+T+ E +P +   G++  GRLD D+ GLL+ + +G L   L
Sbjct: 74  IMLHKPAGFVTTMSDPQGRRTVAELVPTERYPGLFPIGRLDFDTTGLLLFSTDGELGNGL 133

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE------------ 146
             P     K Y   VEG PT+  L  LR G+ L+DGPT PA   +V+             
Sbjct: 134 LHPKHHVTKRYLACVEGRPTERDLALLRRGIELDDGPTQPADVRVVEGGAARHAERLLEI 193

Query: 147 PAWLWPRN----PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
           PA + PR+      + E ++   S +++ + EGR RQV+RM A VG P L L R + G  
Sbjct: 194 PAAVPPRSSKEYAAVCEGRATRRSIVRLGIREGRKRQVKRMLAAVGHPVLALHRDSFGPL 253

Query: 203 SLDNLANGEWREV 215
            L +L  G WR +
Sbjct: 254 ELGDLPRGAWRAL 266


>UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=Q65HX7_BACLD
          Length = 244

 Score =  110 bits (275), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 67/182 (36%), Positives = 96/182 (52%), Gaps = 16/182 (8%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGAL 94
           +P   +L+ KP  V+    D+ GRK + +F     + +Y  GRLD D+ GLL+LTN+G  
Sbjct: 59  EPVYFLLY-KPRGVISAVKDDKGRKVVTDFFTEVEERIYPIGRLDYDTSGLLLLTNDGDF 117

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             +L  P     K Y  +++GIP ++ L+ L  GV L DG T PA  +L+          
Sbjct: 118 ANKLMHPKYEINKTYVAKLKGIPLKENLKKLERGVRLEDGKTAPAKVKLLSLD------- 170

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                 K   TS ++IT++EGRNRQVRRM   +G   L+L R      +L  L  GE RE
Sbjct: 171 ------KKKQTSIVQITIHEGRNRQVRRMFEAIGHEVLKLKREEYAFLNLAGLKTGEKRE 224

Query: 215 VT 216
           +T
Sbjct: 225 LT 226


>UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A4J9G8_DESRM
          Length = 249

 Score =  110 bits (274), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 68/181 (37%), Positives = 98/181 (54%), Gaps = 21/181 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVY---AAGRLDRDSEGLLVLTNNGALQARL 98
           ++ NKP DVL    D + +  +    P    +     GRLD+D+EGLL+LTNNG L  +L
Sbjct: 69  LMLNKPQDVLSATEDASDKVVIDLLDPTYHSFNPFPVGRLDKDTEGLLLLTNNGKLAHQL 128

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPI 157
             P K   K YY  V+G+ T++ + A   GV L+DG  TLP   +++             
Sbjct: 129 LSPKKHVPKTYYALVQGLVTEEDVAAFARGVELDDGYRTLPGQLKII------------- 175

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
              +S P S +++T+YEG+  QV+RM   VG   + L R +MG   LD NL  GE+RE+T
Sbjct: 176 ---RSAPQSEIELTIYEGKYHQVKRMFEAVGKRVIYLKRLSMGPLVLDNNLKPGEYRELT 232

Query: 217 D 217
           D
Sbjct: 233 D 233


>UniRef50_A8FRI1 Pseudouridine synthase n=17 Tax=Bacteria RepID=A8FRI1_SHESH
          Length = 218

 Score =  110 bits (274), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 75/184 (40%), Positives = 100/184 (54%), Gaps = 11/184 (5%)

Query: 36  NQPTRVILFNKPYDVLPQFTDE--AGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNG 92
           +QP       KPY  L QF  E    +K L E      G  A GRLD DSEGLL+LT +G
Sbjct: 28  SQPHHHYKIFKPYGYLSQFVPERRKSKKLLAELALFPAGTMAIGRLDHDSEGLLLLTTDG 87

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP----TLPAGA-ELVDEP 147
            +  ++    K+  K YYVQV+G     A+  L+ GV +        TLP    +L +EP
Sbjct: 88  MVSHQVRS--KKVEKEYYVQVDGDIDDAAILKLQTGVEIGIKGEKYLTLPCKVFKLENEP 145

Query: 148 AWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNL 207
                   P R+ K  P SW+ IT+ EG+NRQ+R+MTA  GFPTLRL+R  +G+  LD +
Sbjct: 146 ELPSNGRKP-RDPKHGPMSWVSITIGEGKNRQIRKMTAAAGFPTLRLVRVRIGNIHLDRM 204

Query: 208 ANGE 211
            +GE
Sbjct: 205 QSGE 208


>UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KIR7_9FIRM
          Length = 250

 Score =  109 bits (272), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 11/178 (6%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L NKP   L    D+ GR+T+ + +P   + VY  GRLD ++EGLL++TN+GAL   L 
Sbjct: 68  LLLNKPKGYLSTAKDDRGRRTVLDLLPEVRERVYPVGRLDNNTEGLLLITNDGALMNGLL 127

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y+  V G  T++ L+ LR+G+ L DG T PA   L+ E      R P  R 
Sbjct: 128 HPRFEVEKTYHAGVTGKLTEEKLQMLRDGLLLEDGMTAPAKVSLLPE------REPGERV 181

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R     +   IT++EGRNRQVRRM A VG     L R      +L  +A G+ R +T+
Sbjct: 182 R---GLTRAAITIHEGRNRQVRRMFAAVGCDVKSLKRVRFAGLTLKGVARGQHRALTE 236


>UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q24V73_DESHY
          Length = 257

 Score =  109 bits (272), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 79/178 (44%), Positives = 98/178 (55%), Gaps = 18/178 (10%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           L +KP   +   TD  GRKT+ E +P   + VY  GRLD D+ GLL+LTN+G L  RL  
Sbjct: 80  LLHKPTGYITSVTDPQGRKTVMELMPKIPRRVYPVGRLDYDTSGLLLLTNDGDLAHRLMH 139

Query: 101 PGKRTGKIYYVQV-EGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           P     K Y V+V E IP Q AL+ L  GV L DG T PA    V       P+      
Sbjct: 140 PSYGVEKTYRVEVGEKIPEQ-ALKRLEKGVLLEDGKTAPARIREVS------PKG----- 187

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           R S+PT   +IT++EGRNRQVRRM   VGFP   L R   G   LD +LA G +R ++
Sbjct: 188 RGSLPT--YEITIHEGRNRQVRRMFKAVGFPLSTLKRLRFGPLELDPSLAPGAFRTLS 243


>UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2S0_9FIRM
          Length = 290

 Score =  109 bits (272), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 66/177 (37%), Positives = 94/177 (53%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           IL +KP   L    D+ GR+T+ + +P     +Y  GRLD D+EGLL++TN+GA+   L 
Sbjct: 66  ILLHKPRGCLSTAYDDRGRRTVLDLLPHFPARLYPVGRLDADTEGLLIITNDGAMTQGLL 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K+Y  +V G  T+D L ALRNG+ L+DG T PA   ++              E
Sbjct: 126 HPRFEIDKVYRAEVTGNVTEDGLTALRNGILLDDGRTAPARLRVLHREG----------E 175

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R  + T      ++EGR RQVRRM A +G    RL R      +LD ++ G +R +T
Sbjct: 176 RTVVET-----IIHEGRKRQVRRMFAAIGCRVQRLCRVRFAMLTLDGVSCGSFRHLT 227


>UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr0361 n=21
           Tax=Cyanobacteria RepID=Y361_SYNY3
          Length = 249

 Score =  108 bits (271), Expect = 9e-23,   Method: Compositional matrix adjust.
 Identities = 74/200 (37%), Positives = 106/200 (53%), Gaps = 25/200 (12%)

Query: 24  FSSQRSTRRKPENQPTRV-ILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGR 77
           F S    + K +N+P  + +L NKP DVL    D  GRKT+ + +P      +G++  GR
Sbjct: 48  FLSVDGKQIKADNRPRDIYLLVNKPRDVLSTCDDPRGRKTVLDLLPQDLQRGKGLHPVGR 107

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LDR+S G L+LTN+G L  RLT P     K Y V +EG P+ + LE  R+G+ L+   TL
Sbjct: 108 LDRNSTGALLLTNDGELTLRLTHPRYHLPKTYDVWLEGNPSDEDLEKWRSGMMLDGKKTL 167

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           PA  E++ E             +  I    L +TL EGRNRQ+RR+   +G   L+L R 
Sbjct: 168 PATLEVISE------------NKDQI---HLLVTLTEGRNRQIRRLAEELGLTVLKLHRR 212

Query: 198 AMGDYSLDN----LANGEWR 213
            +G   L      L +G++R
Sbjct: 213 TIGPLQLHTRGKVLGSGQFR 232


>UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B n=200 Tax=Bacteria
           RepID=RLUB_BACSU
          Length = 244

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 68/187 (36%), Positives = 97/187 (51%), Gaps = 17/187 (9%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEF---IPVQGVYAAGRLDRDSEGLLVLT 89
           K E +     L  KP  V+    D+ GRK + +F   IP Q +Y  GRLD D+ GLL+LT
Sbjct: 54  KVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIP-QRIYPIGRLDYDTSGLLLLT 112

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           N+G    +L  P     K Y  +V+GIP ++ L  L  G+ L +G T PA A+L+     
Sbjct: 113 NDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTAPAKAKLLSLD-- 170

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                      K   TS +++T++EGRNRQVRRM   +G   ++L R      +L  L  
Sbjct: 171 -----------KKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLHT 219

Query: 210 GEWREVT 216
           G+ RE+T
Sbjct: 220 GDARELT 226


>UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine bacterium 105
           RepID=Q6SI36_9BACT
          Length = 255

 Score =  107 bits (267), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 66/188 (35%), Positives = 100/188 (53%), Gaps = 13/188 (6%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVL 88
           R+    +P   +L  KP   +    D  GR+T+   I    + VY  GRLD DSEGL++L
Sbjct: 58  RKVKTGRPRIYLLVCKPRGYVTTRFDPEGRRTILNLISNVREYVYPVGRLDYDSEGLVIL 117

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN+G L ARLT P     ++Y V+V G+P+Q A+++LR+GV +N   T  +  + +    
Sbjct: 118 TNDGTLAARLTHPRYGVERVYEVRVRGVPSQAAIDSLRHGVLINGRRTASSSVKFLRRLK 177

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                       KS   + L++ + EGRNRQVR+M   +G P +RL R  +G     +L 
Sbjct: 178 A-----------KSSENALLRVAIREGRNRQVRKMCEAIGHPVIRLRRTQIGPLRDSSLK 226

Query: 209 NGEWREVT 216
            G+ R +T
Sbjct: 227 VGKHRLLT 234


>UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine synthase B n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3D27
          Length = 271

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 69/190 (36%), Positives = 99/190 (52%), Gaps = 22/190 (11%)

Query: 35  ENQPTRV--ILF---NKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLV 87
           ++QP R   +++   NKP   L    D AGR    + +P   Q VY  GRLD  S+GLL+
Sbjct: 52  DDQPVRAEKLVYWAVNKPVGHLCTNHDPAGRPRAVDLLPHVEQRVYTVGRLDEGSDGLLL 111

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEP 147
           +TN+G L   LT P     K+Y+V V G PT D L+ L +GV L+DG      A+     
Sbjct: 112 MTNDGDLAQGLTHPRYGVPKMYFVLVAGRPTDDDLQKLMDGVWLSDGKVRAKSAK----- 166

Query: 148 AWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNL 207
                     R +     +W+++ L EG+NR++RRM A  G   +RL R A+G   LD L
Sbjct: 167 ----------RIKAQGNGTWVRVVLTEGKNREIRRMLAKFGHKVMRLKRVAIGPVKLDKL 216

Query: 208 ANGEWREVTD 217
             G+ R ++D
Sbjct: 217 PKGKARRISD 226


>UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyrosolvens DSM 2782
           RepID=C7ICF2_9CLOT
          Length = 235

 Score =  107 bits (266), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 59/178 (33%), Positives = 95/178 (53%), Gaps = 17/178 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           I+ NKP   +    D+ GR  + + +   G  +Y  GRLD D+ GL++LTN+G    RLT
Sbjct: 66  IMLNKPVGYVSTSKDQFGRPAVIDLVKDAGKRLYPVGRLDYDTSGLILLTNDGDFTYRLT 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K+Y   + G P ++ +     G+ ++D  T PA  E+++              
Sbjct: 126 HPKHEVNKVYEAVISGFPDKNEITRFETGLKIDDYQTSPAEFEVLN-------------- 171

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +K I T  ++IT++EG+NRQVR+M   +G   L L R  +G  +L+NL  G+WR ++D
Sbjct: 172 KKGINT-LVRITIHEGKNRQVRKMCEAIGHKVLTLKRIQIGPIALENLPEGKWRHLSD 228


>UniRef50_C5KJS4 Pseudouridine synthase, putative n=2 Tax=Perkinsus marinus ATCC
           50983 RepID=C5KJS4_9ALVE
          Length = 267

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 70/166 (42%), Positives = 92/166 (55%), Gaps = 5/166 (3%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVY--AAGRLDRDSEGLLVLTNNGALQARLT 99
           +L +KP   +    D   R T+ + +P   VY  A+GRLD+D+ GLL+LTN+  LQ+ L 
Sbjct: 53  LLMHKPAGYVVSRDDPLNRDTVFQLLPDPSVYIGASGRLDKDTTGLLLLTNDTYLQSSLV 112

Query: 100 QPGKRTGKIYYVQVEGIPTQDA-LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P  +  K+Y V V+G     A L ALR+GV+L DGPTLPA  E +D      P    + 
Sbjct: 113 DPVYKVPKVYRVVVKGAALNGAQLMALRSGVSLEDGPTLPALVEPLDVNGDPLPLE--MS 170

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
           E        L ITL+EGRNRQVRRM   VG     L R  +G +SL
Sbjct: 171 EYDRYKCKQLNITLWEGRNRQVRRMVEAVGSTVRDLCRIQLGPFSL 216


>UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracellularis PHE/MN1-00
           RepID=Q1MQ05_LAWIP
          Length = 270

 Score =  106 bits (265), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 68/175 (38%), Positives = 91/175 (52%), Gaps = 22/175 (12%)

Query: 46  KPYDVLPQFTDEAGRKTLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           KP  V+    D   R T+ +FIP       +Y  GRLD  SEGLL++TN+G L  RLT P
Sbjct: 94  KPIKVISSVKDPQNRLTVLDFIPFPWKNYRLYPVGRLDFFSEGLLLITNDGELTQRLTHP 153

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
                K+Y+V +        L+ +  G+TL+DG  LP        PA        +R   
Sbjct: 154 RYHISKVYHVLIRERILNTTLKNISKGITLSDGTKLP--------PA-------KVRVLS 198

Query: 162 SIP---TSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           SI    T+WL+ITL +G NRQ+RRM   +G   L+LIR   G+ +L NL  GE R
Sbjct: 199 SITETNTTWLEITLQQGINRQIRRMCKELGLTILKLIRVKQGNINLSNLQPGEVR 253


>UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KY92_THERP
          Length = 282

 Score =  106 bits (265), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 67/183 (36%), Positives = 96/183 (52%), Gaps = 16/183 (8%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGA 93
            ++P R I+ +KP   +    DE GRKT+ + + V + V   GRLDRDS GLL+LTN+G 
Sbjct: 63  HSEPRRYIVLHKPVGYITTTADEYGRKTVLDLVQVPERVVPVGRLDRDSSGLLLLTNDGD 122

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  R+T P     K Y V V+G P  +  EALR GV ++  P      E +         
Sbjct: 123 LIYRITHPRYELEKEYEVLVDGFPPPEVEEALRRGVPVDGRPVRIRRLEAI--------- 173

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                 R     +  ++ ++EGRNR +RR+   VG+P LRL R  +G   L +L  G WR
Sbjct: 174 ------RVEPQGTVYRVVIHEGRNRIIRRVFERVGYPVLRLQRVRVGPLRLGDLPPGRWR 227

Query: 214 EVT 216
           ++T
Sbjct: 228 DLT 230


>UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7I2_9ACTN
          Length = 285

 Score =  106 bits (264), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 8/183 (4%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP  VL   +D  G   +   +P     G++  GRLD D+ G+L+ T NG +  RL
Sbjct: 88  LLLNKPSQVLTTMSDPFGFPCVASLVPCDDYPGLFPVGRLDSDTTGVLLFTTNGNMGNRL 147

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV--DEPAWLWPRNPP 156
             P     K Y   +EG  T   ++ L  G+ L DG T P     +  DEP     +N  
Sbjct: 148 LHPSHHVWKTYVALIEGKLTSSQMQKLSQGIMLEDGMTSPCFIRTITQDEPCTHLDKNHS 207

Query: 157 IRE--RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWR 213
           + +  R +  +S  ++ ++EGRN QV+RM   +G P ++L R+  G   L+  +  G WR
Sbjct: 208 LFDDMRLNAASSLCELKIHEGRNHQVKRMLQEIGHPVIKLHRFQFGPLCLNAQIPLGSWR 267

Query: 214 EVT 216
             T
Sbjct: 268 MCT 270


>UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium RepID=A5TWE7_FUSNP
          Length = 234

 Score =  106 bits (264), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 16/182 (8%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGAL 94
           N+     + NKP +VL   +D+ GRKT+ + I   + ++  GRLD  + GL++LTN+G L
Sbjct: 58  NEEKVYFMLNKPLEVLSSSSDDRGRKTVVDLIKTDKRIFPIGRLDYMTSGLILLTNDGEL 117

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             R+  P     K YY+++ G   ++ ++ L+ GV L+DG TLPA           + +N
Sbjct: 118 FNRVVHPKSEIYKKYYIKILGELKKEEIDELKKGVLLDDGKTLPAKI-----SGIKYDKN 172

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                     TS   I++ EGRNRQ+RRM     +  L L R  +G+ +L +L  G++RE
Sbjct: 173 ---------KTSMF-ISIREGRNRQIRRMIEKFEYKVLMLRREKIGELALGDLPEGKYRE 222

Query: 215 VT 216
           +T
Sbjct: 223 LT 224


>UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9GX03_SORC5
          Length = 399

 Score =  105 bits (263), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +  +KP +V+    D  GR T+ + +   G  +Y  GRLD  + G+L++TN+G     L 
Sbjct: 65  VALHKPRNVVSTLRDPEGRPTVADHVRGTGARLYPVGRLDFATSGILLMTNDGDFANALL 124

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y ++V+G+ + D L   R G+ L DG TLPA A L+               
Sbjct: 125 HPRGGVPKTYVLKVQGVMSDDDLTPWREGIRLEDGVTLPAEARLL--------------- 169

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R     +WL++TL EGRN+Q+RRM    G+P +RL R      S + L  GEWR +T
Sbjct: 170 RHEGDKTWLEVTLREGRNQQIRRMGEATGWPVMRLARTTFAGVSSEGLRPGEWRALT 226


>UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IR68_ACIBL
          Length = 254

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 66/176 (37%), Positives = 94/176 (53%), Gaps = 17/176 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAA--GRLDRDSEGLLVLTNNGALQARLTQ 100
           + NKP  ++   +DE GR+T+   +P    + A  GRLD+ SEGLL+LTN+    A++T 
Sbjct: 76  VVNKPRGLITTASDEKGRETIYSLLPPDSPWVAPVGRLDKASEGLLLLTNDSEWAAKITD 135

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y+VQV  +P++  +EAL  G+  +DG  L     L    + L         R
Sbjct: 136 PNSHLDKTYHVQVSTLPSEQMVEALSRGIR-SDGELL-----LAKRVSIL---------R 180

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                 WL+I L EG+NRQ+RRM A +    LRLIR A+G  +L  L  G  R +T
Sbjct: 181 AGGKNGWLEIVLEEGKNRQIRRMVAALQIEVLRLIRVAIGPLTLGELPKGGCRALT 236


>UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C7P2_SPHTD
          Length = 337

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 69/187 (36%), Positives = 103/187 (55%), Gaps = 18/187 (9%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLT 89
           R +PE +  R I+ NKP   +   +DE GR+T+ + + V + V  AGRLDR + GLL+LT
Sbjct: 55  RLRPERR--RYIMLNKPPGYITTVSDERGRRTVMDLVQVPERVVPAGRLDRPTAGLLLLT 112

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           N+G L  R+T P     K Y V V+G P  + L+ LR GVT++    +P           
Sbjct: 113 NDGDLLFRITHPRYELEKEYEVLVDGHPPPEVLDQLRRGVTVDGERVVPDQVR------- 165

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                 P+R  ++   + L+I ++EGRNR VRRM   VG+P L+L R  +G   +  +  
Sbjct: 166 ------PLRIEEA--GTVLRIVIHEGRNRIVRRMMDRVGYPVLKLTRTRIGPIHVRGVPL 217

Query: 210 GEWREVT 216
           G WR++T
Sbjct: 218 GAWRDLT 224


>UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B0TFD8_HELMI
          Length = 333

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 67/173 (38%), Positives = 91/173 (52%), Gaps = 17/173 (9%)

Query: 46  KPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGK 103
           KP  V+    D  GR+T+   +    + VY  GRLDRD+EGLL+LTN+G L  RLT P  
Sbjct: 73  KPRGVVTTCKDPQGRQTVIGLLSGVNERVYPVGRLDRDTEGLLLLTNDGQLAFRLTHPRF 132

Query: 104 RTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSI 163
              K Y  ++ G  +  AL+AL  GV L DG T PA   L+               R+  
Sbjct: 133 GVEKTYRARLRGDVSAGALKALAEGVQLEDGVTAPAQVRLL---------------RREG 177

Query: 164 PTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
             +W++I ++EGR RQ+RRM   +G P + L R A G  +L  L  GE R +T
Sbjct: 178 DATWIEIKIHEGRKRQIRRMGDAIGHPVIDLERIAFGPITLGKLKPGEVRPLT 230


>UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadales
           RepID=B3E7C4_GEOLS
          Length = 274

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 64/174 (36%), Positives = 89/174 (51%), Gaps = 17/174 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L +KP   +    D  GR+ + E +   G  ++  GRLD +SEGLL+LTN+GA   RL 
Sbjct: 66  VLLHKPAGYVTSLKDPQGRQLVTELVKDVGERLFPVGRLDYNSEGLLLLTNDGAWANRLM 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y+V+V G      ++ L +GV L DGPT      L+               
Sbjct: 126 HPRHQVDKEYHVRVRGKIDPQQIKKLADGVELEDGPTGATTVRLL--------------- 170

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           +      WL +T+ EGRNRQVRRM A VG   +RL R   G+ +L  L  GE+R
Sbjct: 171 KNDQSNDWLSVTIREGRNRQVRRMCAAVGLFVVRLRRIRYGNLTLGGLQPGEYR 224


>UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID=B7L2Z9_METC4
          Length = 320

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 66/179 (36%), Positives = 94/179 (52%), Gaps = 18/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV---YAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP  +L  + D  GRKT+ + +    +      GRLD  SEGLL++TN+     RL
Sbjct: 87  LLLNKPRGLLTTYGDPQGRKTVYDCLAGHDLPFLAPVGRLDCASEGLLLMTNDTRWAHRL 146

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K+Y+VQ++  P +  L  LR GV  +DG  L A +     P  +  RN    
Sbjct: 147 LDPASNVDKVYHVQIDRRPDEALLTGLREGVA-HDGERLAAKSV---APLRVGERN---- 198

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                  +WL++ L EGRNRQ+RRM A  G   LRL+R A+G   L ++  G +R +TD
Sbjct: 199 -------AWLEVVLSEGRNRQIRRMMALNGAEVLRLVRVAVGGVRLGDVRKGAFRHLTD 250


>UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZQL4_9PLAN
          Length = 517

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 66/175 (37%), Positives = 93/175 (53%), Gaps = 18/175 (10%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQGV--YAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           + NKP  VL    D AGR  + + +P Q V  +  GRLDR SEGL+V+TN+G L  RL  
Sbjct: 80  MLNKPPGVLSTNFDPAGRTRVIDMVP-QDVRLFTIGRLDRASEGLIVVTNDGELANRLAH 138

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y V+V G P  DA+  +R GV L +G   P                  + +R
Sbjct: 139 PRYEIEKTYRVEVAGHPEPDAITFVRRGVHLAEGFVQPVSV---------------VMKR 183

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           K+  ++ L++ L EG+NR++RR+ A +G   LRL R AMG   L  +  G +RE+
Sbjct: 184 KNKQSTTLEVILDEGKNREIRRLMAKIGHKVLRLKRIAMGPLRLGEMPEGAFREL 238


>UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae RepID=C8WAL4_ATOPD
          Length = 279

 Score =  103 bits (257), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 60/182 (32%), Positives = 88/182 (48%), Gaps = 6/182 (3%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARL 98
           ++ NKP   L    D  GR T+ + +P     G++  GRLD D+ GLL  T +G +   L
Sbjct: 72  LMLNKPAGYLTTMKDPQGRPTIVDMVPTDTYPGLFPVGRLDMDTTGLLFFTTDGQMAQEL 131

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P K   K Y   V G PT++ L  LR G+ L DGP  PA  E++ +   +     P  
Sbjct: 132 LHPSKHVWKHYVAHVVGTPTEEQLNRLREGIELEDGPAAPAEVEIISDDVKMKNLLAPQG 191

Query: 159 ERKS---IPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
             K+    P + + +T+ EGR  QV++M   +    L L R   G   L  +  GEWR +
Sbjct: 192 LGKTGGGEPNALVSVTIREGRKHQVKKMLLAIHHRVLALHRDTFGPLHLTRVKEGEWRLL 251

Query: 216 TD 217
           T+
Sbjct: 252 TE 253


>UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales RepID=C7H5G4_9FIRM
          Length = 294

 Score =  103 bits (256), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 67/187 (35%), Positives = 98/187 (52%), Gaps = 22/187 (11%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEF---IPVQGVYAAGRLDRDSEGLLVLTNN 91
           +NQ    +   KP   +   +DE GRKT+ E    IP + +Y  GRLD+DSEGLL++TN+
Sbjct: 78  KNQQLYYLALYKPRGYVTTASDELGRKTVMELVSDIPAR-LYPVGRLDKDSEGLLLMTND 136

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPAGAELV-DEPAW 149
           GA    +T P     K+Y V V+    +  +  + +GV L+DG  T+P    +V DEP  
Sbjct: 137 GAFAQAVTHPSGGISKLYRVTVQPRADESQILKMSSGVVLDDGTKTMPCAINVVTDEPGR 196

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                           + +++TL EG+NR++RRM   VG   +RL R A G   L  L  
Sbjct: 197 ----------------TVMEMTLKEGKNREIRRMCEAVGLEVVRLKRNAEGVVKLGMLKP 240

Query: 210 GEWREVT 216
           G +RE+T
Sbjct: 241 GTYRELT 247


>UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium curtum DSM 15641
           RepID=C7MNA2_CRYCD
          Length = 296

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 58/179 (32%), Positives = 89/179 (49%), Gaps = 18/179 (10%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGAL 94
           P   +  NKP  ++    D  GR+ + + +P +   G++  GRLD+D+ GLL+ + +G L
Sbjct: 109 PAVTLALNKPAGIITTMKDLRGRRCVADIMPTEQYPGLFPIGRLDQDTTGLLLFSTDGNL 168

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              L  P     K+Y   +EG   Q ALE L +G+ L+DG T PA   +V          
Sbjct: 169 GNALLHPSHGVSKVYRATIEGSIGQAALEQLASGILLDDGMTAPARVSVV---------- 218

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                +     S +++ L+EGR  QV+RM   VG P ++L R + G   L  LA G +R
Sbjct: 219 -----QAGKKHSVIELELHEGRKHQVKRMCQAVGHPVVKLHRASFGPIDLAGLATGAYR 272


>UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MIA3_BDEBA
          Length = 265

 Score =  101 bits (252), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 67/189 (35%), Positives = 95/189 (50%), Gaps = 15/189 (7%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVL 88
           RKP  Q    IL NKP  VL    D   R T+ E++   PV+ V+  GRLD DSEG+L+L
Sbjct: 36  RKPLTQKIYAIL-NKPTGVLTTMDDPHDRPTVAEYLTELPVR-VFPVGRLDWDSEGMLLL 93

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN+G    ++  P     K Y V++ G P    LE L+ GV++  G       E + +  
Sbjct: 94  TNDGDFANKVMHPKAEVTKTYLVKLNGKPEPFQLEKLKKGVSIVGGKVSARHIEKIKKTG 153

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                     + KS    W KI + EG+NRQ+R+M A +GF  +RL R A+G   +  + 
Sbjct: 154 ----------DNKSEKYEWYKIVITEGKNRQIRQMFAKIGFDVMRLQRVAIGRLRMGAVK 203

Query: 209 NGEWREVTD 217
            GE   + D
Sbjct: 204 TGELVYLND 212


>UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6G735_9DELT
          Length = 300

 Score =  101 bits (251), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 70/193 (36%), Positives = 101/193 (52%), Gaps = 23/193 (11%)

Query: 29  STRRKPENQPTRVI-LFNKPYDVLPQF---TDEAGRKTLKEFIPVQGV----YAAGRLDR 80
           + R +P    ++V  + NKP  V+       DE GR T+   +   GV    Y  GRLD 
Sbjct: 79  TVRGEPIQAESKVYYVLNKPDGVVSSAAGSVDERGRPTVISLL--HGVSERLYPVGRLDF 136

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAG 140
            S G+L+LTN+G L   LT P     K Y+V+ +G  T++  + LR+GV L+DG      
Sbjct: 137 HSRGVLLLTNDGGLAEALTHPRHGVVKTYHVKFQGKLTEEQEQLLRDGVELDDGAITRPV 196

Query: 141 AELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
           AEL    A+          R++    W +I + EG NRQ+RRM   +G P L+LIR A+G
Sbjct: 197 AELF---AF----------RETATNVWYQIGIREGLNRQIRRMGEAIGHPVLKLIRVAIG 243

Query: 201 DYSLDNLANGEWR 213
           D + D +  GE+R
Sbjct: 244 DITADGVPEGEFR 256


>UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae RepID=A5IKF7_THEP1
          Length = 239

 Score =  101 bits (251), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 63/174 (36%), Positives = 98/174 (56%), Gaps = 21/174 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           ILF+KP   +   T +   +T+ EF+P ++G++  GRLD+D+EGLL++T++G    R+  
Sbjct: 62  ILFHKPSGYVTS-TKDPHSETIMEFLPPLKGIFPVGRLDKDAEGLLIITSDGDFAHRVIS 120

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y V+VEG  T+D +E L+NGVTL DG    A A+ V++              
Sbjct: 121 PKWSVEKEYIVKVEGEVTEDKIEKLKNGVTLRDG--FFAKAKCVEK-------------- 164

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWR 213
             +    LKI + EG+  Q++RMT  VG  T+ L R  +G   L +++  GE+R
Sbjct: 165 --LSNDTLKIVITEGKYHQIKRMTVAVGLRTVHLKRTRIGRLVLPEDMKPGEYR 216


>UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5KLG0_9FIRM
          Length = 261

 Score =  100 bits (250), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 66/192 (34%), Positives = 104/192 (54%), Gaps = 20/192 (10%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + NKP  V+    D+  R T+ + I     + ++ AGRLD+D+EGLL++TN+G L  RL 
Sbjct: 66  MLNKPAGVVSATEDKKER-TVIDLIKESKRKDLFPAGRLDKDTEGLLLITNDGQLAHRLL 124

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND-GPTLPAGAELVDEPAWLWPRNPPIR 158
            P K   KIYY +++GI T++ +     GV + D  PT+PA  E++        R   I+
Sbjct: 125 SPKKHVDKIYYAKIKGIVTEEDVRLFEKGVHIGDEKPTMPAALEIL--SVQKERRKEKIK 182

Query: 159 ERKSIPT------------SWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD- 205
           E+K +P             S + +T+ EGR  QV+RM   VG   + L R   G  +LD 
Sbjct: 183 EQKILPETKNETDEKEDGYSEIYLTIKEGRFHQVKRMFRAVGKEVVYLKRIQFGTLTLDP 242

Query: 206 NLANGEWREVTD 217
           +L  G++R++T+
Sbjct: 243 SLKPGQYRKLTE 254


>UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termitidis ATCC 33386
           RepID=D1AL84_SEBTE
          Length = 233

 Score =  100 bits (249), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 67/179 (37%), Positives = 91/179 (50%), Gaps = 23/179 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTL---KEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           I+ NKP DV+    DE  R  L   +E +   G++  GRLD+D+EGLLVLTN+G +   L
Sbjct: 63  IMLNKPQDVISATDDERHRTVLDLLEEPLTKVGLFPVGRLDKDTEGLLVLTNDGKMAHEL 122

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P K   K YYV+++   +++    L NGV L    T PA  E + E            
Sbjct: 123 LSPKKHVPKRYYVELKKTLSKEEAAILENGVELETFTTKPAKVEFITE------------ 170

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
                    + I + EG+  QV+RM   VG   L L R  MG+  LD NLA GE+RE+T
Sbjct: 171 -------DKVYIIISEGKYHQVKRMFKCVGNRVLFLKRTGMGNLGLDENLAPGEYRELT 222


>UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LSY4_SYNAS
          Length = 251

 Score =  100 bits (249), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 64/174 (36%), Positives = 86/174 (49%), Gaps = 17/174 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV--YAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ NKP   +   +D   R  +   +P  GV  +  GRLD DSEGLL+LTN+G    R+ 
Sbjct: 66  VMLNKPRGYVTALSDPQKRPLVIHLLPELGVRLFPVGRLDYDSEGLLLLTNDGGFAQRVQ 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  R  K Y V++ G         L+ G+ L DG   P      DE A L   NP    
Sbjct: 126 HPRYRISKTYRVKISGRLNAAEFNRLQKGLELEDGKFAP------DEVA-LEEINP---- 174

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                +SWL + + EGRNR +RR    +G   LRLIR A+ D  L NL  G++R
Sbjct: 175 ----KSSWLTMKISEGRNRVIRRAFEQLGHEVLRLIRTAVADLHLGNLREGDYR 224


>UniRef50_Q1RJR2 Uncharacterized RNA pseudouridine synthase RBE_0321 n=15
           Tax=Rickettsia RepID=Y321_RICBR
          Length = 229

 Score = 99.8 bits (247), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 59/182 (32%), Positives = 95/182 (52%), Gaps = 17/182 (9%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTL-KEFIPVQGVYAAGRLDRDSEGLLVLTNNGAL 94
           +Q +R+ ++ KP  ++    D   RKT+ ++   +  V + GRLD +SEGLL+LTNNG L
Sbjct: 58  SQKSRLWIYYKPVGLITTHKDPLSRKTVFEQLTGLPRVISIGRLDLNSEGLLLLTNNGDL 117

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             +   P  +  ++Y+V+  G P                 P L +  + ++     +   
Sbjct: 118 ARQFELPSSKLKRVYHVRAYGNP----------------DPLLKSNYKNLEIDGIFYNPQ 161

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                RK+   SWL++ L+EG+NR++RR+  H G    +LIR   GD+ LDNL   E+RE
Sbjct: 162 SIKLLRKNSTNSWLEVILFEGKNREIRRIFEHFGLKVNKLIRTEYGDFKLDNLKPNEYRE 221

Query: 215 VT 216
           VT
Sbjct: 222 VT 223


>UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomonas noxia ATCC 43541
           RepID=UPI0001BCEF2E
          Length = 296

 Score = 99.8 bits (247), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 64/179 (35%), Positives = 94/179 (52%), Gaps = 21/179 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           IL NKP   L    D+ GRKT+ + +P     +Y  GRLD D+EG+L++TN+GA+   L 
Sbjct: 66  ILLNKPRGYLSTARDDRGRKTVLDLLPDFPARLYPVGRLDADTEGVLLITNDGAITQGLL 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K+Y+ +V G  T+  L  LR G+ L DG T  A   ++               
Sbjct: 126 HPRFEIDKVYHAEVAGPVTEGGLTRLRRGILLEDGMTASAKLRIL--------------- 170

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVG--FPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R     + ++  ++EGRNRQVRRM A +G     LR +R+AM   +L  L+ G +R +T
Sbjct: 171 RADKGYTVVETIIHEGRNRQVRRMFAAIGCRVCALRRVRFAM--LTLRGLSCGSFRHLT 227


>UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3ESK0_9BACT
          Length = 616

 Score = 99.8 bits (247), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 66/178 (37%), Positives = 94/178 (52%), Gaps = 17/178 (9%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + LF KP  ++    D   + TLK+F P +  +   GRLD  SEG+L+LTNNG L  R+ 
Sbjct: 80  LFLFYKPKGIVSTLHDPDEKTTLKDFFPQINPLIHVGRLDIQSEGVLLLTNNGDLAQRIL 139

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P     + Y V+V+G+   + L+ LR+G V L+  P  P   E               +
Sbjct: 140 HPRYEIPRTYLVKVQGVVKPEHLDRLRSGKVRLDGRPVQPLELE---------------Q 184

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ER +   SW +ITL EGRNR+VRR+   + +  L+L R A G+  L  L  GE+R VT
Sbjct: 185 ERLTETNSWYRITLTEGRNREVRRLFDALHYFVLKLTRIAFGNLDLAGLEPGEYRLVT 242


>UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1F236_ACIC5
          Length = 406

 Score = 99.8 bits (247), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 94/181 (51%), Gaps = 15/181 (8%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-----VYAAGRLDRDSEGLLVLTNNGAL 94
           R  + NKP   +   +D  GR T+ EF   +G     +Y  GRLD  SEGLL++TN+GAL
Sbjct: 85  RYFMLNKPKGYVTTVSDPEGRHTVMEFFHGRGKGGERLYPVGRLDYASEGLLLMTNDGAL 144

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              LT+      K+Y V+V G PT++ LE +R G+ ++ G   P    ++  PA      
Sbjct: 145 ANTLTKASSHVEKVYLVKVSGRPTEEQLEQIRAGIMIDRG--RPGEGRVMTAPAG----- 197

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
             +R  +     W ++TL EGRNR++R+M    G    ++ R   G   LD +  GE RE
Sbjct: 198 --VRMVRDAENPWFELTLIEGRNREIRKMFEETGHFVEKIRRIGYGPLVLD-VEPGEVRE 254

Query: 215 V 215
           +
Sbjct: 255 L 255


>UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MIA1_RHOM4
          Length = 268

 Score = 99.8 bits (247), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 66/181 (36%), Positives = 92/181 (50%), Gaps = 22/181 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQ--GVYAAGRLDRDSEGLLVLTNNGALQA 96
           IL NKP+D +    DE GR+T+ + I   P Q  G++  GRLDR++ G+L+LTN+G L  
Sbjct: 72  ILMNKPHDTITTCDDERGRRTVLDLINLPPEQKNGLFPVGRLDRNTTGVLLLTNDGELAN 131

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           RL  P  R  KIY  +       +  E LR GV L DGP     A  V     + P +P 
Sbjct: 132 RLMHPRYRVEKIYVARTARPVKPEEAEQLRRGVQLEDGP-----ARAVQ--VAVNPADP- 183

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                      + + +YEGRNRQVRRM   +G   ++L R      +   +  G+WR +T
Sbjct: 184 ---------HEIALMIYEGRNRQVRRMLEAIGHEVVQLKRTHYAGLTTKGVRPGKWRRLT 234

Query: 217 D 217
           D
Sbjct: 235 D 235


>UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=A3CPQ5_STRSV
          Length = 242

 Score = 99.4 bits (246), Expect = 7e-20,   Method: Compositional matrix adjust.
 Identities = 57/176 (32%), Positives = 93/176 (52%), Gaps = 15/176 (8%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           L NKP  V+   +D+ GRKT+ E +P   + +Y  GRLD D+ G+L+LTN+G     +  
Sbjct: 63  LLNKPRGVISSVSDDKGRKTVVELLPQVKERIYPVGRLDWDTSGILILTNDGDFTDEMIH 122

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K+Y  +V+G+  ++ L  L  G+ +    T PA  E++        +  P + R
Sbjct: 123 PRNEIDKVYVARVKGLANKEVLRPLTRGIEIEGRKTKPAVYEII--------KVDPAKNR 174

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                S +++T++EGRN QV++M   VG    +L R   G   L  L  GE+R+++
Sbjct: 175 -----SVVQLTIHEGRNHQVKKMFQAVGLQVDKLSRTRFGHLDLTGLKPGEYRKLS 225


>UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0LG91_HALO1
          Length = 553

 Score = 99.4 bits (246), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 69/179 (38%), Positives = 92/179 (51%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP   L   TD   R T+ E++   P + V   GRLD  SEG+L+LTN+G L ARL
Sbjct: 67  VLLNKPKGCLTAVTDPENRPTVMEYLHGLPAR-VVPVGRLDFYSEGVLLLTNDGDLSARL 125

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPI 157
             P     K Y+V+V    T+  LE LR GV L DG  T PA    +D       R+   
Sbjct: 126 QSPRHHVEKTYHVKVRDQVTERHLEVLRQGVRLEDGTVTRPA---QIDMLGGTKSRH--- 179

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                    WL ITL EG++RQ+ RM   +G+  ++L R A G  +   L  G+ RE+T
Sbjct: 180 --------DWLVITLTEGKSRQIHRMLGVLGYTVMKLQRVAFGGLTFHGLRVGDARELT 230


>UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae RepID=B3QY10_CHLT3
          Length = 297

 Score = 99.0 bits (245), Expect = 9e-20,   Method: Compositional matrix adjust.
 Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 21/185 (11%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGA 93
           EN     IL NKP DV+   +DE  RKT+ E + ++  V+  GRLDRD+ G+L+LTN+G 
Sbjct: 99  ENTQKIYILLNKPKDVVTTSSDEKSRKTVVELVGLKDRVFPVGRLDRDTTGVLLLTNDGD 158

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLW 151
           L  RLT P     K Y   ++   T   L+ ++ G  L D      P  A ++D+   +W
Sbjct: 159 LTYRLTHPTFGVQKQYVATLDKKITSVDLQNIKKGFRLKDTGEKVSPCNARILDDGYTIW 218

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                             + ++EG+N Q+ RM    G+   +L+R A G   +  +  GE
Sbjct: 219 ------------------VAIHEGKNHQIHRMFWSFGYNVKKLVRVAYGGLEVGTMRRGE 260

Query: 212 WREVT 216
           WR +T
Sbjct: 261 WRFLT 265


>UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Z61_SOLUE
          Length = 264

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 63/177 (35%), Positives = 91/177 (51%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAA--GRLDRDSEGLLVLTNNGALQARLT 99
           IL  KP   L  + D  GR T+   +   G + +  GRLD D+ GLLVLTN+     R+T
Sbjct: 76  ILLYKPKGYLTTYRDPEGRPTVYALLGDVGKWLSPVGRLDLDTSGLLVLTNDNDFAERIT 135

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y ++   + + + +E LR GV L+DGPT PA  +               R 
Sbjct: 136 NPEHKVPKTYQIKAATVLSDEQIERLRAGVELSDGPTRPAEVK---------------RL 180

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R     ++L++T+ EGRNRQVRRM   V     +L+R A+G   +  L  G+WR +T
Sbjct: 181 RDGPKHTFLEMTITEGRNRQVRRMLEAVESKVSKLVRTAIGPVRIGELPIGKWRNLT 237


>UniRef50_C8N9M2 RNA pseudouridine synthase family protein n=1 Tax=Cardiobacterium
           hominis ATCC 15826 RepID=C8N9M2_9GAMM
          Length = 141

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 51/93 (54%), Positives = 66/93 (70%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +IL NKP++VL QFTD++GR TL +++ V  VY AG LD DSEGL+VLT++G LQAR+  
Sbjct: 30  LILLNKPFNVLCQFTDKSGRATLADYVDVPNVYPAGLLDFDSEGLVVLTDDGRLQARIAD 89

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLND 133
           P  +  K Y+VQVEG   + AL  LR GV L D
Sbjct: 90  PRFKLAKRYWVQVEGEADEAALVQLRAGVWLKD 122


>UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B6IXC3_RHOCS
          Length = 551

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 69/187 (36%), Positives = 96/187 (51%), Gaps = 23/187 (12%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNN 91
           PE +PTRV  ++KP  ++    DE GR T+ + +P +   V + GRLD  SEGLL+LTN+
Sbjct: 85  PEPEPTRVWRYHKPDGLVTTARDEKGRPTVFDNLPPELPRVVSVGRLDLTSEGLLLLTND 144

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND---GPTLPAGAELVDEPA 148
           GAL   L  P     + Y V+V G P +  +  L  G+ +     GP       +VD   
Sbjct: 145 GALARHLELPVTGWLRRYRVRVHGAPDEAQIAKLAQGIIIEGIEYGPI----ETVVD--- 197

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                      R     +WL ++L EGRNR+VRR+  H+G P  RLIR A G + L  L 
Sbjct: 198 -----------RSVGANTWLTVSLREGRNREVRRVMEHLGLPVSRLIRVAYGPFQLGKLE 246

Query: 209 NGEWREV 215
            G+  EV
Sbjct: 247 PGQVEEV 253


>UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5V220_ROSS1
          Length = 624

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 62/177 (35%), Positives = 97/177 (54%), Gaps = 16/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           ++ +KP  V+    D  GR T+ + + + Q ++  GRLD DSEGLL+LT++G L  +LT 
Sbjct: 67  VMLHKPAGVVSTTDDPQGRPTVIDLVNLEQRLFPVGRLDYDSEGLLLLTDDGELTQKLTH 126

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P  +  K Y V +   P+  AL A R GV L+   T PA  EL++               
Sbjct: 127 PSYQVEKEYRVLLNEAPSPAALRAWRTGVELDGVKTAPAWVELIE--------------- 171

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           ++   +W+++ L+EGR RQ+R +   +G+   RLIR   G  +L +L +G WR +TD
Sbjct: 172 RTPDGAWVRVILHEGRKRQIREVARVLGYEVRRLIRVREGPLTLGDLPSGTWRFLTD 228


>UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZD4_9DELT
          Length = 240

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 60/178 (33%), Positives = 93/178 (52%), Gaps = 19/178 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L NKP   +    D  GR  +   I  P   ++  GRLD D+EG L+LTN+G L   + 
Sbjct: 66  VLLNKPAGYVTTMADPQGRPIVTSLINEPGLRLFPVGRLDLDTEGALLLTNDGELAQNIL 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P ++  + Y+  V+G P ++AL+ LR G+ L    T PA                 IRE
Sbjct: 126 HPSRQINRTYHATVKGRPNREALQQLRRGIMLEGRRTWPAR----------------IRE 169

Query: 160 -RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            R++  ++ L++ ++EGR RQVR+M A +  P L+L R A G   L +L  G +R ++
Sbjct: 170 LRRNQESTTLEVIIHEGRKRQVRKMFAAINHPVLQLKRVAYGGLRLGSLPTGRYRRLS 227


>UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapolitana DSM 4359
           RepID=B9KC52_THENN
          Length = 240

 Score = 97.8 bits (242), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 67/179 (37%), Positives = 98/179 (54%), Gaps = 22/179 (12%)

Query: 38  PTRV-ILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQ 95
           P +V ILF KP   +   T +   +T+ EF+P ++G++  GRLD+D+EGLL++TN+G   
Sbjct: 57  PEKVYILFYKPAGYVTS-TRDPHSETIMEFLPDIKGIFPVGRLDKDAEGLLLVTNDGEFA 115

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
            R+  P  +  K Y V+VEG  T+D LE LR GV+L DG    A A+ V++         
Sbjct: 116 HRVISPRWKVEKEYVVKVEGEITEDKLEKLRRGVSLRDG--FFAKAKHVEK--------- 164

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWR 213
                  I    +KI + EG+  QV+RM A VG  T+ L R  +G   L   +  GE+R
Sbjct: 165 -------ISNDTVKIVITEGKYHQVKRMMAAVGLKTIHLKRVRIGGLRLPQEMKPGEYR 216


>UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria RepID=Q3MC44_ANAVT
          Length = 288

 Score = 97.4 bits (241), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 69/206 (33%), Positives = 98/206 (47%), Gaps = 32/206 (15%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-----GVYAAG 76
           K  S+QR  R          +L NKP  V+    D  GRKT+ + +P +     G++  G
Sbjct: 80  KSVSAQRHHR-------LTYLLLNKPTGVVSTCYDPQGRKTVLDLLPEELRKGSGLHPVG 132

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLD  S G L+LTN+G L  +LT P     K Y + V+G P +  L+  R GV L+   T
Sbjct: 133 RLDAYSTGALILTNDGDLTFKLTHPSHNIPKTYQILVKGHPPEAVLKMWREGVLLDGRKT 192

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
             A   L++  A                 S L+I L EGRNRQ+RR+   +G+P ++L R
Sbjct: 193 RKAKVSLLESLA---------------EKSRLEIVLQEGRNRQIRRVAEQLGYPVIKLHR 237

Query: 197 YAMGDYSLDN-----LANGEWREVTD 217
            A+G   L       L  G +R + D
Sbjct: 238 TAIGSIQLQTSKQPLLRAGNYRILRD 263


>UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XS61_9BACT
          Length = 235

 Score = 97.4 bits (241), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 59/178 (33%), Positives = 92/178 (51%), Gaps = 17/178 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +  NKP   +    D+  RK + + +P +   +Y+ GRLD DSEGL+ LTN+G     LT
Sbjct: 64  VALNKPRGYVCSRKDDRKRKVIGDLLPAEWDNLYSVGRLDSDSEGLIFLTNDGEFSLHLT 123

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  R  K Y   VEG   Q+ L+  ++G+ +++G  L      VD    L  +N     
Sbjct: 124 HPRYRVLKKYLATVEGRVEQEMLQRFKHGI-VHEGEKLK-----VDRARTLSVQN----- 172

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                TS +++ L EG+NR++RR+    G    RL+R  +G   L  L +G+WR +T+
Sbjct: 173 ----STSLVELELTEGKNREIRRLFESQGLTVSRLVRMQIGKIKLGELRSGKWRMLTE 226


>UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID=Q6G8H4_STAAS
          Length = 231

 Score = 97.1 bits (240), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 65/204 (31%), Positives = 95/204 (46%), Gaps = 36/204 (17%)

Query: 30  TRRKPENQPTRV------------ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYA 74
           T  +PEN    V            I+ NKP D +   T++   KT+ + IP      ++ 
Sbjct: 39  THIEPENDKITVRGELIEYIENVYIMLNKPKDYISA-TEDHHSKTVIDLIPEYQHLNIFT 97

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
            GRLD+D+EGLL++TN+G     L  P K   K Y V      T+D ++A + GVTL+DG
Sbjct: 98  VGRLDKDTEGLLLITNDGDFNHELMSPNKHVSKKYEVISANPITEDDIQAFKEGVTLSDG 157

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
              PA    +D                        +T+YEG+  QV+RM   +    L L
Sbjct: 158 KVKPAILTYIDNQTS-------------------HVTIYEGKYHQVKRMFHSIQNEVLHL 198

Query: 195 IRYAMGDYSLD-NLANGEWREVTD 217
            R  + D  LD NL +GE+R +T+
Sbjct: 199 RRIKIADLELDSNLDSGEYRLLTE 222


>UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_1464 n=4 Tax=Bacteria
           RepID=Y1464_AQUAE
          Length = 249

 Score = 97.1 bits (240), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 64/183 (34%), Positives = 89/183 (48%), Gaps = 18/183 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEA-GRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGA 93
           Q  R I+ NKP   L Q      GRKT++E I    + V+  GRLD ++EGLL+LTN+G 
Sbjct: 61  QRKRYIILNKPCCYLTQLGRSPDGRKTIEELIKDIPERVFPVGRLDYNTEGLLILTNDGE 120

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  R+  P  +  K+Y   VEG   Q  L+ ++ G+ L DG   P    +V         
Sbjct: 121 LANRILHPRYKLPKVYLALVEGKVDQKTLKRMKQGIELEDGFAKPDNIRIV--------- 171

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                 R     + L+IT +EGR   V+R     G    RL R A+G   L  L+ G+WR
Sbjct: 172 ------RYEGKNTLLEITFHEGRKHLVKRFLGAFGHKVKRLKRIAIGPIKLGKLSPGKWR 225

Query: 214 EVT 216
           E+ 
Sbjct: 226 ELN 228


>UniRef50_A9BF27 Pseudouridine synthase n=1 Tax=Petrotoga mobilis SJ95
           RepID=A9BF27_PETMO
          Length = 220

 Score = 96.7 bits (239), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 60/178 (33%), Positives = 95/178 (53%), Gaps = 21/178 (11%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLV 87
           ++K EN+     L NKP  +L  F D+ GRKT+ + I     + V+  GRLD DS GLL+
Sbjct: 34  QKKAENKV--YYLLNKPKGILCTFKDDFGRKTINDLIKGKIEERVFYVGRLDYDSSGLLL 91

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPAGAELVDE 146
           LTN+G L   L +P  +  K+Y V V+G P++  L+ L  G+TL  G  T+ +  +++  
Sbjct: 92  LTNDGDLANYLLRPENKVTKVYEVLVKGSPSKKELQMLEEGITLETGYKTMKSKVKIL-- 149

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                        +K    S L+I+L EG+ RQ++ M   +G+  + L R   G +S+
Sbjct: 150 -------------KKQKDLSLLQISLNEGKKRQIKLMIKALGYKVIELKRIKFGPWSI 194


>UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=Q1J0B9_DEIGD
          Length = 253

 Score = 96.7 bits (239), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 66/178 (37%), Positives = 83/178 (46%), Gaps = 21/178 (11%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRK-TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQ 95
           Q +   L  KP   +    DE GR+  L    P+ G++  GRLD+DSEGLL+LT +G L 
Sbjct: 63  QESVTFLLYKPAGYVTTARDEYGRRNVLSAMPPIPGLHPVGRLDKDSEGLLLLTTDGQLT 122

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
             LT P     K Y     G P    L  L  G+ L DGP     A              
Sbjct: 123 LTLTHPRYGHEKAYRAWTAGQPVAAELRVLETGIELADGPARALSAR------------- 169

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           P R           +TL EGRNRQVRRM   +G+P  RL+RY +G   L +L  GE+R
Sbjct: 170 PAR-------GGALVTLTEGRNRQVRRMLDAIGYPVHRLLRYRVGGLWLGDLEPGEYR 220


>UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae RepID=Q1GFA6_SILST
          Length = 422

 Score = 96.7 bits (239), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 62/184 (33%), Positives = 95/184 (51%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           PE +  R+ L+ KP  ++   +DE GRKT+ + +P  +  V   GRLD +SEGLL+LTN+
Sbjct: 116 PEAEAPRLWLYYKPNGLVTTTSDEKGRKTIFDALPEDLPRVMTVGRLDLNSEGLLLLTND 175

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G ++ +L  P     + Y V++ G P     + LR GV ++     P    L        
Sbjct: 176 GGVKRQLELPSTGWLRRYRVRINGRPQDHEFDVLRKGVVIDGERFQPMTISL-------- 227

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  +R+    +WL I L EG+NR++RR    VG+P  RL+R + G + L  L  GE
Sbjct: 228 -------DRQQGANAWLTIGLREGKNREIRRAMEEVGYPVNRLLRISYGPFQLGTLKEGE 280

Query: 212 WREV 215
             E+
Sbjct: 281 VEEL 284


>UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes RepID=Q11YT0_CYTH3
          Length = 562

 Score = 96.7 bits (239), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 21/179 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP D +    DE  RKT+ + +     + +Y  GRLDR++ GLL+ TN+G L  +L
Sbjct: 390 VLLNKPKDFITTMEDENDRKTVMQLVANATKERIYPVGRLDRNTTGLLLFTNDGELAQKL 449

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           T P  +  KIY V+++   T +  + + +G + L DGP        VDE A + P     
Sbjct: 450 THPSNKVKKIYEVELDKPITAEDFDKIVDGKIHLFDGPV------KVDEAAIISP----- 498

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                     + I ++EGRNR VRR+   +G+  L+L R      +  N+  G WR +T
Sbjct: 499 ------SKKIIGIEIHEGRNRIVRRIFESLGYDVLKLDRVMYAGLTKKNIPRGSWRYLT 551


>UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterineae
           RepID=A4QE19_CORGB
          Length = 320

 Score = 96.7 bits (239), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 61/183 (33%), Positives = 89/183 (48%), Gaps = 20/183 (10%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLLVLTN 90
           N+     + NKP  +    +DE GR  + + +       Q ++  GRLD D+EGLL+LTN
Sbjct: 137 NEDLEYFVLNKPRGMHSTMSDELGRPCVGDLVSEKTASGQRLFHVGRLDADTEGLLLLTN 196

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L  RL  P     K Y   V G  T   + ALR+GV L DGP     A+++D     
Sbjct: 197 DGELANRLMHPKYEVSKTYLATVRGEATNKLVSALRDGVELEDGPAKADFAQIID----- 251

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                 + + KS+    L+I ++EGR   VRR+   +GFP  RL+R  +    L +   G
Sbjct: 252 ------VFQGKSL----LRIEIHEGRKHIVRRLFDELGFPVERLVRTKLHTVQLGDQKPG 301

Query: 211 EWR 213
             R
Sbjct: 302 SLR 304


>UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q31GA0_THICR
          Length = 317

 Score = 96.3 bits (238), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 69/191 (36%), Positives = 101/191 (52%), Gaps = 21/191 (10%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVY-AAGRLDRDSEGLLVLTNN 91
           E QPT+VIL+NKP   +    DE GR+T+   +P  +   + + GRLD ++ GLL+LTNN
Sbjct: 76  EKQPTQVILYNKPEGQVCSRKDEKGRETIFTSLPRIINSRWISVGRLDINTSGLLILTNN 135

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L  RL  P     + Y V+V G  + + L+ L+ GV L DG    A  E + +     
Sbjct: 136 GELANRLMHPSYEMEREYSVRVFGEVSDEILDRLKKGVKLEDG---FAKFESIGK----- 187

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANG 210
               P +E  SI   W ++ + EGRNR+VRR+    G    RL+R   G +SL  NL  G
Sbjct: 188 ---IPQQEEDSI-NQWYRVVIKEGRNREVRRIWESQGVQVSRLVRTRYGQFSLPRNLRRG 243

Query: 211 E-----WREVT 216
           +     W+++ 
Sbjct: 244 KSEPLTWKQIN 254


>UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus RepID=B5ELL5_ACIF5
          Length = 268

 Score = 96.3 bits (238), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 65/176 (36%), Positives = 86/176 (48%), Gaps = 18/176 (10%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYA-AGRLDRDSEGLLVLTNNGALQARL 98
           +V+L +KP  VL    DE GR T+ + +P     A  GRLD+ S GLL+ +N+     RL
Sbjct: 84  QVLLLHKPRGVLTTRQDERGRATVYDLLPGSPWLAPVGRLDQASSGLLLFSNDPHWAQRL 143

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P +   K Y+VQ+    + D +  L     L+  P LP                  IR
Sbjct: 144 LDPDQHVAKTYHVQIRPPLSTDTVVQLAADSVLDGEPCLPMQ----------------IR 187

Query: 159 E-RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           E R    T WL+  L EGRNRQ+RR+ A      LRLIR A+G+  L  L  GEWR
Sbjct: 188 ELRCGGKTQWLEFILQEGRNRQIRRLLAACDREVLRLIRVAVGNLPLGELRAGEWR 243


>UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HYA4_9BACT
          Length = 638

 Score = 96.3 bits (238), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 68/187 (36%), Positives = 100/187 (53%), Gaps = 20/187 (10%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTN 90
           R+PE   T + LF KP  V+    D  GR TL+++ P +  +   GRLD  +EG L+LTN
Sbjct: 82  REPE---TFLFLFYKPKGVVSTLFDPEGRPTLRDYFPGIDPLLHIGRLDFQTEGALLLTN 138

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNG-VTLNDGPTLPAGAELVDEPAW 149
           NG L  R+  P     + Y V+++G  +   LE +  G + L+  P +P   ELV E   
Sbjct: 139 NGDLSQRILHPRFEIPRTYLVKIQGGMSPAHLERMARGEIRLDGRPVVPL--ELVPE--- 193

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                     R++   +W +ITL EGRNR+VRR+   + +  L+L+R A G  +L  L  
Sbjct: 194 ----------RQTSTNAWYRITLTEGRNREVRRLFETLNYFVLKLVRTAFGPLTLAGLEP 243

Query: 210 GEWREVT 216
           GE+R VT
Sbjct: 244 GEYRTVT 250


>UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZC3_ERYRH
          Length = 246

 Score = 95.9 bits (237), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 54/174 (31%), Positives = 91/174 (52%), Gaps = 14/174 (8%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           + NKP  ++    D+  R+++ + +P    V+  GRLDR++ G L+LTN+G     +T P
Sbjct: 70  ILNKPRGIVSSANDDKDRESVVDLVPNDIRVFPVGRLDRETTGALILTNDGDFAYYMTHP 129

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
                KIY V V G  + +   +L+ G+T+        G E      +       ++   
Sbjct: 130 KFDLSKIYRVSVRGRLSYEVTNSLKEGITIE-------GVE------YKGVEISRVKYDA 176

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +   +   ITL+EG+NRQ+R++ AH G P L+L RY +G   +D L  G++RE+
Sbjct: 177 AKDKTQFSITLHEGKNRQIRKIFAHFGLPVLKLHRYQIGYLDIDELKIGQYREL 230


>UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID=C1XV14_9DEIN
          Length = 369

 Score = 95.5 bits (236), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 62/178 (34%), Positives = 88/178 (49%), Gaps = 22/178 (12%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           VI  +KP  V    +D    +T+ + +P V G++  GRLD+DSEGLL+LTN+G L  +LT
Sbjct: 61  VIALHKPVGVTTTKSDPHAERTVYQLVPDVPGLHPVGRLDKDSEGLLLLTNDGDLTLKLT 120

Query: 100 QPGKRTGKIYYVQVE-GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P     K+Y    + G  ++     L  GV L+DG      AE   E A          
Sbjct: 121 HPRYGVRKVYRAWCKHGRVSEADCRRLVEGVALDDGLAQALEAEPTQEGA---------- 170

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                     +I + EG+ R+VRRM   +G+P  RL+R  +G   L  L  GEWR +T
Sbjct: 171 ----------RIVMAEGKKREVRRMLGRLGYPVTRLVRLQVGPIKLGKLNPGEWRYLT 218


>UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2G3_SALRD
          Length = 249

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 62/177 (35%), Positives = 93/177 (52%), Gaps = 21/177 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQA 96
           +L NKP D +    D   R+T+ + I V      G++  GRLDR++ G+L+++N+G L  
Sbjct: 72  LLLNKPKDTISTTDDPKDRRTVLDAIGVPEDNPSGLFPVGRLDRNTTGVLLVSNDGDLAH 131

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           RL  P     KIYYV+V+       L+ L+ GV L+D      GA   D+ A+L P    
Sbjct: 132 RLMHPRYEIPKIYYVRVQDDVKPHQLDQLKRGVELSD------GAAAADQVAYLDP---- 181

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
             +RK    + + + L+EGRNRQ+RRM   +G   ++L R      +   L  GEWR
Sbjct: 182 --QRK----TDIALELHEGRNRQIRRMMEALGHTIVQLERAKYATLTTGRLQRGEWR 232


>UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actinobacterium
           RepID=D0U645_9ACTN
          Length = 237

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 58/176 (32%), Positives = 86/176 (48%), Gaps = 21/176 (11%)

Query: 44  FNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
            +KP  VL    D  GR +L +FI +  + ++  GRLD+DSEGL++LTN+G L  R T P
Sbjct: 69  LHKPKGVLSTMFDPEGRPSLDDFIDLRKERLFHVGRLDKDSEGLILLTNDGDLTFRATHP 128

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
                K Y ++ +GI      + L  GV L DG                      +   K
Sbjct: 129 SFGLEKTYIIEFDGILPTGVDKVLLKGVELEDG-------------------MGRVLTFK 169

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            +   W++++++EGR   +RR+   VG   LRLIR   G  SL +   G WR++ D
Sbjct: 170 QLSPKWIEVSIHEGRYHIIRRLMEAVGVNVLRLIRTKFGPISLGDTPEGRWRDLND 225


>UniRef50_Q2NZN4 Pseudouridine synthase n=13 Tax=Xanthomonadaceae RepID=Q2NZN4_XANOM
          Length = 286

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 64/188 (34%), Positives = 95/188 (50%), Gaps = 14/188 (7%)

Query: 33  KPENQPTRV-ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVL 88
           +P   P R  ++ NKP  V+    DE GR T+       G   +   GRLD+ SEGLL+ 
Sbjct: 90  QPLTGPARCYLMLNKPRGVVTTVRDEQGRDTVYRCFDGAGLPWIAPVGRLDKASEGLLLF 149

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           +N+    A +T P     K Y+VQ++ +P    L  L+ GV   D    P G  ++    
Sbjct: 150 SNDPQWAATVTDPATGPDKTYHVQIDCLPNVAQLAQLQAGVVDPD----PEGEGML---- 201

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
            L  +   +  R+    +WL+I L EGRNRQ+RR+ A V    LRL+R A+G  ++  L 
Sbjct: 202 -LRAKQVSVL-REGERNAWLEIVLDEGRNRQIRRLLAAVDIGVLRLMRVAIGPLAMGELG 259

Query: 209 NGEWREVT 216
            G WR ++
Sbjct: 260 KGAWRMLS 267


>UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales RepID=B4U4Q4_STREM
          Length = 266

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 57/183 (31%), Positives = 96/183 (52%), Gaps = 15/183 (8%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGA 93
           N+     L NKP  V+   +D+ GR+T+ + +P   + +Y  GRLD D+ GLL+LTN+G 
Sbjct: 82  NEEKVYYLLNKPRGVISSVSDDKGRQTVIDLLPQVKERIYPVGRLDWDTSGLLILTNDGD 141

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
              ++  P     K+Y  +V+G+ T+++L  L  GV ++   T PA   ++        R
Sbjct: 142 FTDKMIHPRNEIDKVYLARVKGVVTKESLRPLTRGVVIDGKKTKPARYRII--------R 193

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
             P + R     S +++T++EGR+ QV++M   VG    +L R   G   +  L  GE R
Sbjct: 194 VEPDKNR-----SIVELTIHEGRHHQVKKMFEAVGHLVDKLSRTQFGSLDVRGLKPGEAR 248

Query: 214 EVT 216
            ++
Sbjct: 249 RLS 251


>UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S1L0_FINM2
          Length = 242

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 56/174 (32%), Positives = 87/174 (50%), Gaps = 17/174 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           I  NKP        D+   K + + I     VY  GRLD+DS GLL+LTN+G     LT 
Sbjct: 63  IAINKPIGYASTVKDKFADKKVVDLIKSDTRVYPVGRLDKDSHGLLILTNDGEFTYELTH 122

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     KIY V V+G P +  ++ L++G+ L+      +  E ++               
Sbjct: 123 PKFEHKKIYEVLVKGKPNKTEIKQLKDGILLDGYKLKKSKIEFIENVK------------ 170

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWR 213
                +  ++T++EGRNRQ+RRM   +  P L L R  +G+Y ++N L +GE++
Sbjct: 171 ---NDTKYRVTIFEGRNRQIRRMFDFINHPVLDLKRVQIGNYKMENSLKSGEYK 221


>UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroidetes
           RepID=D2QMI8_9SPHI
          Length = 638

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 20/175 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP D +    D   RKT+ E +   G   +Y  GRLDR++ GLL++TN+G L  +L
Sbjct: 466 VLLNKPKDYITTTEDPEERKTVMELVADAGKFRMYPVGRLDRNTTGLLLITNDGELADKL 525

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     KIY V+++   T +  EA++ G+ L DGP  P    +V   A++        
Sbjct: 526 THPSNNIRKIYQVELDKPITDEHFEAIKKGIELEDGPIKPDAISIVTPDAYV-------- 577

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                    + I ++ GRNR VRR+    G+   +L R      +   L  G+WR
Sbjct: 578 ---------VGIEIHSGRNRIVRRIFESFGYEVTKLDRTTYAGLTKKELPRGKWR 623


>UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VG32_9BACT
          Length = 279

 Score = 94.7 bits (234), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 63/174 (36%), Positives = 84/174 (48%), Gaps = 17/174 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ NKP   +    DE GRKT+   +P +G  +  AGRLD++SEGLL  TN+ AL   LT
Sbjct: 103 LILNKPRGYVVSQNDELGRKTVYSLLPPKGKQLAYAGRLDKESEGLLFFTNDTALINLLT 162

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K+Y V +        L  LR GV +  G TLPAG  +               +
Sbjct: 163 HPKNKVEKVYRVDINRPLNNMELNMLRKGVEIEGGKTLPAGIFV---------------K 207

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
            K+     LKI + EGR RQ+R+M   VG     L R   G   L +L  G WR
Sbjct: 208 SKNANGMTLKIVITEGRKRQIRQMIEAVGAKVTYLKRLQFGPLKLKDLPVGRWR 261


>UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organisms
           RepID=A4CJ52_9FLAO
          Length = 303

 Score = 94.4 bits (233), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 57/179 (31%), Positives = 89/179 (49%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP + +    DE GR+T+ E I       +   GRLDR++ GLL+ TN+G L  +L
Sbjct: 131 VLLNKPRNFITTTRDEKGRRTVMELISRASNARLVPVGRLDRNTTGLLLFTNDGELAKKL 190

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     KIY+V+++       L  LR G+ L DG         VDE +++        
Sbjct: 191 THPKHGVRKIYHVELDKTFKSADLGKLREGLELEDGRI------EVDEASYI-------- 236

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                    + + L+ GRNR VRR+  H+G+  ++L R  +   +  +L  G WR +T+
Sbjct: 237 --DGASKKEVGVELHSGRNRIVRRIFEHLGYQVVKLDRVVLAGLTKKDLPRGHWRHLTE 293


>UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodictyon group
           RepID=Q3B289_PELLD
          Length = 250

 Score = 94.4 bits (233), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 59/178 (33%), Positives = 92/178 (51%), Gaps = 21/178 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           ILFNKP +V+   +DE  R+ + +FI V + VY  GRLDR + G+L+LTN+G L  +L  
Sbjct: 77  ILFNKPRNVITTSSDERNREMVLDFIDVNERVYPVGRLDRKTTGVLLLTNDGMLANKLMH 136

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIR 158
           P     K Y   ++    Q +L  L  G+ L+D      P  A+++ + + +W       
Sbjct: 137 PSSNVKKEYIAVLDAPFPQASLPLLTGGMRLSDTGEKVSPCQAKIMGDGSQVW------- 189

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                      I+++EG+N QVRRM   +GF   RL R      ++ +L  G+WR +T
Sbjct: 190 -----------ISIHEGKNHQVRRMFKTLGFEVTRLDRPTYAGLTVGDLRRGQWRHLT 236


>UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales RepID=C5WHE9_STRDG
          Length = 245

 Score = 94.0 bits (232), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 64/178 (35%), Positives = 85/178 (47%), Gaps = 17/178 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKT---LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + NKP   L    D A       L E    + V+  GRLD+D+ GLL+LTNNG L   L 
Sbjct: 66  ILNKPAGFLSATKDRAQATVIDLLDETARQKDVFPVGRLDKDTRGLLLLTNNGQLAHDLL 125

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P K   K Y  +V GI T    +    G++L D   LPA  E++D+             
Sbjct: 126 SPKKHVTKEYLAKVAGIMTDADKDDFAKGISLKDHQCLPAKLEVLDKDL----------- 174

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
             S  T  + IT+ EG+  QV+RM A  G   L L R +MG   LD  LA G++R +T
Sbjct: 175 --SQETCVVSITIQEGKFHQVKRMVAACGKEVLELQRLSMGPLRLDPGLAEGDFRRLT 230


>UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae RepID=A0JV58_ARTS2
          Length = 406

 Score = 94.0 bits (232), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 64/178 (35%), Positives = 87/178 (48%), Gaps = 20/178 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           ++FNKP  V+    D  GR  + +F+     + ++  GRLD  +EGLL+LTN+G L  RL
Sbjct: 231 MVFNKPKGVVSTMEDPDGRPCISDFVRNTHGERLFHVGRLDVATEGLLLLTNDGELANRL 290

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K Y VQV G   Q     L+ GV L DG       +LVD             
Sbjct: 291 THPSYEVPKTYLVQVRGPFPQGIGAQLKAGVELEDGMASVDSFKLVD------------- 337

Query: 159 ERKSIPTSWL-KITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
              S P   L ++ L+ G+NR VRR+   VGFP LRL+R  +G   L +   G  R +
Sbjct: 338 ---STPGHVLIEVVLHSGKNRIVRRLFDAVGFPVLRLVRVKVGPIGLGDQRQGSIRNL 392


>UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q3J464_RHOS4
          Length = 508

 Score = 94.0 bits (232), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 64/181 (35%), Positives = 96/181 (53%), Gaps = 17/181 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGAL 94
           +P R+ L+ KP  ++   +DE GR+T+ + +P  +  V + GRLD +SEGLL+LTN+G L
Sbjct: 65  EPARLWLYYKPEGLVTSASDEKGRETVFDHLPEGMPRVMSVGRLDLNSEGLLLLTNDGEL 124

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
           + RL  P     + Y V+V+G PT   LE LR G+T+      P    L           
Sbjct: 125 KRRLELPSTGWLRKYRVRVKGNPTDADLEPLRKGITVEGESFQPMTVSL----------- 173

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
               +R     +WL + L EG+NR++RR  + +G    RLIR + G + L+ L  G   E
Sbjct: 174 ----DRVQGANAWLTVGLREGKNREIRRAMSALGLTVNRLIRVSYGPFRLNELEPGMVEE 229

Query: 215 V 215
           V
Sbjct: 230 V 230


>UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales RepID=B1XJP9_SYNP2
          Length = 259

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 62/179 (34%), Positives = 89/179 (49%), Gaps = 20/179 (11%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           L +KP  V+    D  GR T+ + +P      +G++  GRLD  S G L+LTN+G     
Sbjct: 68  LIHKPKGVVSTCADPKGRSTVLDLLPPPLRQGKGIHPIGRLDAQSTGALLLTNDGNFTLA 127

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           LT P     K Y V ++G   +  L+  R GV L D  TLP    L             I
Sbjct: 128 LTHPRYHIPKTYRVWLKGKVPEHVLDQWRQGVMLGDRRTLPTQIHLKT-----------I 176

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            + K+     + I L EGRNRQ+RR+   +GFP ++L R A+G+  L +L  G+ R +T
Sbjct: 177 TQDKTC----IDIMLTEGRNRQIRRVAEQLGFPVVKLHRLAIGNLHLGDLQRGQARPLT 231


>UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R7V9_9PLAN
          Length = 811

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 61/179 (34%), Positives = 94/179 (52%), Gaps = 17/179 (9%)

Query: 37  QPTRV-ILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGAL 94
           +P R+  + NKP  V+    D+AGR  + + +P  + V+A GRLDR SEGL+++TN+G  
Sbjct: 90  KPQRLYFVVNKPEGVVTTNYDQAGRTRVIDLVPTDERVFAVGRLDRASEGLIIVTNDGEF 149

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             R+T P     K Y V+V G  +   L  LR G+ L+DG       ++           
Sbjct: 150 ANRVTHPRYGVTKTYLVRVAGEASTAELAKLRRGIHLSDGFCKVDAIQV----------- 198

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
               +R+   ++ + I L EG+NR++RR+ A +G   L+L R A+G   L  L  G WR
Sbjct: 199 ----KRRHKQSTDMVIQLSEGKNREIRRILARIGHKVLKLKRLAVGSLKLGELPLGAWR 253


>UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0N6F1_9FIRM
          Length = 241

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 58/173 (33%), Positives = 86/173 (49%), Gaps = 15/173 (8%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +F KP   +    DE  R  + ++     + +Y  GRLD D+ GL++++N+G     +  
Sbjct: 64  VFYKPKGCVCTLDDEFDRPIITDYFTEVKERIYPVGRLDFDTTGLIIMSNDGEFANMIMH 123

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     KIY V ++G+ T   L  L  GV L    TLP   ++VD+            E 
Sbjct: 124 PRSHLEKIYEVSIKGLITGPTLNKLEKGVYLEGVKTLPCKIKVVDKDT----------EH 173

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           K   T+ LKI L EG+NRQV++M   VG P  RL R ++G  +L  L  G +R
Sbjct: 174 K---TTMLKIKLVEGKNRQVKKMFESVGHPVKRLHRVSIGGINLKGLTPGRYR 223


>UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8G2X0_CHLAD
          Length = 567

 Score = 93.6 bits (231), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 67/191 (35%), Positives = 95/191 (49%), Gaps = 24/191 (12%)

Query: 35  ENQPTRV------ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLV 87
           + QP R+      I+ +KP  V+    D  GR T+ + + V   V+  GRLD DSEGL++
Sbjct: 54  DGQPLRMPAKRTYIMLHKPAGVVSTAEDPHGRPTVVDLVDVPARVFPVGRLDLDSEGLIL 113

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEP 147
           LT++G L   LT P     K Y V ++   T DAL + RNGV L    T PA  EL++  
Sbjct: 114 LTDDGELAYALTHPSFEVEKEYRVLLDRALTPDALRSWRNGVLLEGEMTAPAWVELLE-- 171

Query: 148 AWLWPRNPPIRERKSIPTS-WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN 206
                         + P   W++I L EGR RQ+R +   +G+   RL+R   G   L +
Sbjct: 172 --------------TTPEGVWVRIVLREGRKRQIRAVAKLLGYEVRRLVRVREGPLQLGD 217

Query: 207 LANGEWREVTD 217
           L    WR +TD
Sbjct: 218 LPPRAWRHLTD 228


>UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus RepID=Q49YI4_STAS1
          Length = 232

 Score = 93.6 bits (231), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 62/179 (34%), Positives = 92/179 (51%), Gaps = 23/179 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           ++ NKP D +   TDE   KT+ + I       ++  GRLD+D+EGLL++TN+G     L
Sbjct: 63  LMLNKPKDYISATTDEQ-HKTVLDLIEDYRYLDLFPVGRLDKDTEGLLLITNDGQFNHEL 121

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             PGK   K Y V  +   T++ + A + G+ LN+G   PA     DE            
Sbjct: 122 MSPGKHVAKTYEVISQKNITKNDINAFKVGIELNEGLAKPAKLVQGDE------------ 169

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
               +  S+  +T+YEGR  QV+RM   +    L L R  +GD  LD+ LA+GE+R +T
Sbjct: 170 ----LNKSF--VTIYEGRYHQVKRMFHAIDNEVLALKRIRIGDLQLDSTLASGEYRHLT 222


>UniRef50_Q1D9N8 Pseudouridine synthase n=4 Tax=Cystobacterineae RepID=Q1D9N8_MYXXD
          Length = 268

 Score = 93.6 bits (231), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 66/191 (34%), Positives = 88/191 (46%), Gaps = 27/191 (14%)

Query: 35  ENQPTRVILFNKPYDVLPQF-----TDEAGRKTLKEFIPVQGVY---AAGRLDRDSEGLL 86
           E  PTRV+ F+KP  +L        T       L +  P    Y   A GRLD DS GLL
Sbjct: 80  EAPPTRVLAFHKPAGLLSSTERQHRTGTVFEALLPQLPPELAGYTWHAVGRLDVDSTGLL 139

Query: 87  VLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE 146
           + TN+  L A  T P     K Y   V    + + +E LR G+TL+DGP  PA   + DE
Sbjct: 140 LFTNDDKLVAHATSPDAHLPKRYVATVFSTASDERVEPLRRGMTLDDGPARPAKVNVRDE 199

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN 206
                                +++TL EGR+ QV+RM   VG P   L R A+G   L+ 
Sbjct: 200 -------------------HTVEVTLTEGRHHQVKRMLGAVGLPVRALHREAVGSVDLEG 240

Query: 207 LANGEWREVTD 217
           +  G +R +TD
Sbjct: 241 IPEGTFRLLTD 251


>UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae RepID=A4BW35_9FLAO
          Length = 305

 Score = 93.2 bits (230), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 19/181 (10%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           + IL NKP + +    D+ GRKT+ + I     + +Y  GRLDR++ GLL+ TN+G L  
Sbjct: 131 KYILLNKPKNYITTMDDDRGRKTVMDLISNATKERIYPVGRLDRNTTGLLLFTNDGELAK 190

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           +LT P     K+Y+  ++       LE LR  V +            VD           
Sbjct: 191 KLTHPKHDVRKLYHASLDKKLELKDLEKLRGEVLIEGKKVFIDAVSYVD----------- 239

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                  P S + I ++ GRNR VR++  H+G+   +L R    + +  NL  G WRE+T
Sbjct: 240 -----GQPKSEVGIEIHSGRNRIVRKIFEHLGYKVSKLDRVIFAELTKRNLPRGRWRELT 294

Query: 217 D 217
           +
Sbjct: 295 N 295


>UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis RepID=C8WBY9_ZYMMN
          Length = 509

 Score = 93.2 bits (230), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 66/187 (35%), Positives = 96/187 (51%), Gaps = 19/187 (10%)

Query: 33  KPENQPT--RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVL 88
           KP N PT  R+ L++K   +L    D  GRKT+ + +P     V   GRLD ++EGLL+L
Sbjct: 322 KPVNAPTETRLFLYHKATGLLTTERDPEGRKTIYDRLPADLPRVMPVGRLDMNTEGLLLL 381

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           T +G  +  L  P     + Y  +V G  +QD LE L  GVT++       G       A
Sbjct: 382 TTDGGFKRMLELPATHIERCYRARVFGDVSQDQLEELIEGVTID-------GIHYGSIDA 434

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
            L        ER++    W+++ L+EGRNR+VRR+  ++G    RLIR + G + L +L 
Sbjct: 435 NL--------ERRTGRNGWVEMKLHEGRNREVRRVLGYLGLQVSRLIRISYGPFLLGDLP 486

Query: 209 NGEWREV 215
            G   EV
Sbjct: 487 VGAVEEV 493


>UniRef50_Q11WC7 Pseudouridine synthase n=2 Tax=Sphingobacteriales
           RepID=Q11WC7_CYTH3
          Length = 224

 Score = 93.2 bits (230), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 57/182 (31%), Positives = 95/182 (52%), Gaps = 9/182 (4%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLK--EFIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           R  + NKP++++ QF        L   +F   +G +A GRLD +SEGLL+LT N  +   
Sbjct: 29  RYFIINKPFNMVSQFISSDAVNLLGNLDFTFPEGTHAVGRLDNESEGLLILTTNKKVTRL 88

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL-----NDGPTLPAGAELVDEPAWLWP 152
           L Q  K+  + Y V V+   +++ L+ L+ G+++      +  + P  A +V +   ++ 
Sbjct: 89  LFQGTKKHTRTYLVLVKNKVSEETLKQLQTGISIRVKGGGNYISSPCEASIVTDAKAIYS 148

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                RE  + P +WL +TL EG+  QVR+M   V    LRLIR ++ +  L +L  G  
Sbjct: 149 YAADTRE--NYPHTWLLLTLTEGKFHQVRKMVLAVNHRCLRLIRVSIENMLLHDLQPGAV 206

Query: 213 RE 214
           +E
Sbjct: 207 KE 208


>UniRef50_UPI0001C337CA ribosomal large subunit pseudouridine synthase B n=1
           Tax=cyanobacterium UCYN-A RepID=UPI0001C337CA
          Length = 254

 Score = 93.2 bits (230), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 63/185 (34%), Positives = 89/185 (48%), Gaps = 25/185 (13%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQA 96
           IL NKP  ++    D   R  + + +P       G++  GRLD +S G L+LTN+G L  
Sbjct: 67  ILVNKPVGIICSCKDSQNRSIVMDLLPSNLRKGMGIHPVGRLDMNSSGALLLTNDGNLTL 126

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           RLT P     KIY V V G  TQ  L+  R GV L+   TLPA  E+++           
Sbjct: 127 RLTHPRYHLPKIYEVLVRGNFTQAILKDWRQGVVLDGKKTLPAYLEVINNNRQ------- 179

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-----DNLANGE 211
                    + LKI L EG+NR +RR+        ++L R A+G  SL     DN+  G 
Sbjct: 180 --------YTNLKIILTEGKNRHIRRIAQKFELDVIKLHRTAIGPISLSTSKVDNVKLGH 231

Query: 212 WREVT 216
           +R ++
Sbjct: 232 YRLLS 236


>UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus RepID=Q1J642_STRPF
          Length = 244

 Score = 93.2 bits (230), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 57/146 (39%), Positives = 80/146 (54%), Gaps = 14/146 (9%)

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           V+  GRLD+D+ GLL+LTNNG L   L  P K   K Y  +V GI T+   +    G++L
Sbjct: 97  VFPVGRLDKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIMTEADKDYFARGISL 156

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
            D   LPA  E++            ++++    TS +KIT+ EG+  QV+RM A  G   
Sbjct: 157 KDHQCLPAHLEVL---------ASDLQQQ----TSLVKITIQEGKFHQVKRMVAACGKEV 203

Query: 192 LRLIRYAMGDYSLD-NLANGEWREVT 216
           L L R +MG   LD +LA GE+R +T
Sbjct: 204 LDLQRLSMGPLKLDPSLAEGEFRRLT 229


>UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q1Q0_9BACT
          Length = 260

 Score = 93.2 bits (230), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 56/177 (31%), Positives = 90/177 (50%), Gaps = 17/177 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           L NKP D L    DE  R    + I    Q +Y  GRLD+ SEGL+++TN+G L  +L+ 
Sbjct: 66  LLNKPKDCLCTNYDELNRLRAIDIIKNVKQRLYTIGRLDKQSEGLIIITNDGELSNKLSH 125

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y+++++G  + + + AL++GV L  G T P   +               +  
Sbjct: 126 PKYEVNKTYFIEIDGYLSNETITALQSGVWLAFGKTQPVRIK---------------KMH 170

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +S   S  ++ L EG+NR++RRM A  G     L R  +G     +L  G++R++T+
Sbjct: 171 RSFKKSRFEMILCEGKNREIRRMLADHGHKVRTLRRIKIGSLCDPDLKVGKYRKLTE 227


>UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales RepID=Q47QM5_THEFY
          Length = 375

 Score = 92.8 bits (229), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-----VYAAGRLDRDSEGLLVLTN 90
           +Q  R    NKP  V+    D  GR T+ ++    G     ++  GRLD D+EGL++LTN
Sbjct: 192 SQNLRYYALNKPRGVVSTMFDPEGRPTIGDYAAQIGPIEERLFHVGRLDTDTEGLILLTN 251

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L  RLT P  +  K Y  +V G   +D +  +R GV L+DG        ++D     
Sbjct: 252 DGELANRLTHPRYKVTKTYLAKVPGPVPRDVIRQIRKGVELDDGFVKVDSFRVIDNIE-- 309

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                        P + ++I L+EGR   VRR+   VG P   L R  +G   L+NL +G
Sbjct: 310 -------------PKALVEIRLHEGRKHIVRRLMKAVGHPVSDLARTQIGPVGLNNLKSG 356

Query: 211 EWREVT 216
             R +T
Sbjct: 357 TIRALT 362


>UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytoplasma
           RepID=Q2NIZ3_AYWBP
          Length = 245

 Score = 92.8 bits (229), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 55/174 (31%), Positives = 87/174 (50%), Gaps = 14/174 (8%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           L NKP   L    D+  R T+ + I    +Q +Y  GRLD ++ GLL++TN+G L  +LT
Sbjct: 64  LLNKPNGFLSTAKDKKNRPTVLDLIEEASIQRLYPIGRLDFNTTGLLLITNDGDLTQKLT 123

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y+V++     +  L     G+ + D   L    E+        P+      
Sbjct: 124 HPSFCIPKEYHVKINACLQKKDLSTFCKGIII-DKKYLAVCKEIDILKISYMPK------ 176

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
               P++WLK+ + EG+NRQVR+M   +G+  L+L RY     +++NL  G +R
Sbjct: 177 ----PSTWLKLVITEGKNRQVRKMMQALGYQVLKLKRYRYSFLTIENLTIGAYR 226


>UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6VXU0_DYAFD
          Length = 555

 Score = 92.8 bits (229), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 61/179 (34%), Positives = 88/179 (49%), Gaps = 20/179 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           IL NKP D +    D   RKT+ + I     + VY  GRLDR++ GLL+LTN+G L  +L
Sbjct: 384 ILINKPKDYITTTDDPEERKTVLDIIAGACSERVYPVGRLDRNTTGLLLLTNDGELAEKL 443

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     KIY  +++   T +  E L+ GV L DG   P    LV   A +        
Sbjct: 444 THPSSGIKKIYQAELDKPITTEDFEQLKAGVELEDGFIRPDEVGLVTPDAQV-------- 495

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                    + + ++ GRNR VRRM  H+G+   +L R      +  +L  G+WR +T+
Sbjct: 496 ---------VGLEIHSGRNRIVRRMFEHLGYEVQKLDRTVFAGLNKKDLPRGKWRFLTE 545


>UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1D5Q2_MYXXD
          Length = 745

 Score = 92.0 bits (227), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 17/174 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
            L  KP  V+   +D  GR T+  ++   G  ++  GRLD D+EG L+ T++GAL  +LT
Sbjct: 67  FLLYKPVGVVTTLSDPQGRPTVANYVEETGKRLFPVGRLDYDAEGALLFTDDGALAHKLT 126

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  + Y  +V+G P    L+ LR GV L DG   P    + +             E
Sbjct: 127 HPSFQVPRTYLAKVKGAPDTATLDKLRGGVRLEDGMATPVSVSVFE-----------AAE 175

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           R     +WLKI + EGR   ++R+ A VG P +RL R +     ++ L  GE R
Sbjct: 176 R----NTWLKIVVAEGRPHLIKRLCAAVGHPVVRLFRPSYAGVGVEGLRPGELR 225


>UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C0FY58_9FIRM
          Length = 261

 Score = 92.0 bits (227), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 63/179 (35%), Positives = 94/179 (52%), Gaps = 20/179 (11%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           LF KP   +    D+   KT+ +++       ++  GRLD D+EGLL++TN+GAL   L 
Sbjct: 88  LFYKPAGCVTATEDQL-HKTVMDYLTDTVRSDLFPVGRLDIDTEGLLLITNDGALAHDLL 146

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P K   K YY  ++G+ T+  + +  NGV +        G E + +P  L       R 
Sbjct: 147 SPAKHVEKTYYAVIDGVVTEKDVNSFENGVDI--------GEEKLTKPGKL-------RI 191

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
            KS P S +++T+ EGR  QV+RM   VG   L L R +MG   L D+L  GE+R +T+
Sbjct: 192 LKSEPESEIELTITEGRFHQVKRMFEAVGKKVLYLKRISMGPLQLTDDLKPGEYRPLTE 250


>UniRef50_B8DUD9 Pseudouridine synthase n=8 Tax=Bifidobacterium RepID=B8DUD9_BIFA0
          Length = 257

 Score = 91.7 bits (226), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 31/206 (15%)

Query: 24  FSSQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI--P 68
             ++  TR  P+ Q  RV             +  NKP  VL    D  GR TL++ +   
Sbjct: 51  LVTELGTRVDPKRQQVRVDGSRIRLNPRHITLALNKPRKVLSTMDDPKGRYTLRDIVGDK 110

Query: 69  VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL-RN 127
            + ++  GRLD DSEGL+++TN+G L   +  P     K Y   +EG  +      L R 
Sbjct: 111 YERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATLEGHMSGTVCRRLVRT 170

Query: 128 GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
           GV L+DG              W+   +  I +     T  +K+ L+ GRNR VRR+   +
Sbjct: 171 GVQLDDG--------------WIKLDHCSIIDSNRDQT-IVKVVLHSGRNRIVRRIFGAI 215

Query: 188 GFPTLRLIRYAMGDYSLDNLANGEWR 213
           GFP  RL+R  +G   L ++ +G +R
Sbjct: 216 GFPVKRLVRTQIGPIKLGDIKSGSYR 241


>UniRef50_A5Z4I7 Pseudouridine synthase n=1 Tax=Eubacterium ventriosum ATCC 27560
           RepID=A5Z4I7_9FIRM
          Length = 175

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 61/177 (34%), Positives = 88/177 (49%), Gaps = 20/177 (11%)

Query: 43  LFNKPYDVLPQFTDEAGRKT--LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           + NKP  VL   +D   +    L +  P +G++  GRLD+D+EGLL++TN+G L   L  
Sbjct: 1   MLNKPAGVLSAVSDNNCKTVIDLLDVTPKKGLFPVGRLDKDTEGLLLITNDGELSHNLLS 60

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P K   K YYV++ G      +E    G        L  G + + +PA L      I E+
Sbjct: 61  PAKHVDKTYYVELNGDLIDSDIELFEKG--------LDIGEKNLTKPAIL-----KILEK 107

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           +S       IT+ EG+  QV+RM   +G     L R  MG   LD NL  GE+R++T
Sbjct: 108 RSTAL----ITITEGKYHQVKRMFQAIGLTVTFLKRLTMGPLKLDENLKPGEYRKLT 160


>UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gasseri
           RepID=Q042N1_LACGA
          Length = 245

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 58/184 (31%), Positives = 93/184 (50%), Gaps = 18/184 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNG 92
           Q     L NKP  V+   T++  ++T+   +      QG+   GRLD+D+ GLL+LTN+G
Sbjct: 69  QQYHYFLLNKPKGVISA-TEDRSQQTVISLLKTKDRYQGIAPVGRLDKDTTGLLLLTNDG 127

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
           AL   L  P K   K+Y  ++ G+P  +  +    G+ L DG  L        +PA L  
Sbjct: 128 ALAHELLAPNKHVAKVYRAKIAGVPDPETAKKFAQGLILGDGTKL--------KPAKL-- 177

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGE 211
               +++ +    S ++I + EG+  Q++RM   VG   L L R +MG   L  +L  GE
Sbjct: 178 --KILKQDQDNNLSQIEIQIQEGKYHQIKRMFGAVGMKVLELDRVSMGKLHLPADLKRGE 235

Query: 212 WREV 215
           ++E+
Sbjct: 236 YKEI 239


>UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9AXM1_HERA2
          Length = 728

 Score = 91.3 bits (225), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 65/176 (36%), Positives = 95/176 (53%), Gaps = 16/176 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +L +KP  V+    D  GR+T+ + +     ++  GRLD DSEGLL+LT++G L  RLT 
Sbjct: 65  VLLHKPSSVMTTLHDPEGRQTVADLVKSHNRLFPVGRLDYDSEGLLLLTDDGDLTFRLTH 124

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y   +   P+ + L   RNGV L+DG T PA  EL++E A            
Sbjct: 125 PSFEVEKEYQALLNQTPSVEQLREWRNGVELDDGKTAPAWIELLNETA------------ 172

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                +W+++ ++EGRNRQ+RR+   +G    RLIR   G  +L  L  G+WR +T
Sbjct: 173 ---DGTWVRVVIHEGRNRQIRRVAEALGLEVRRLIRLREGPLTLGELQAGQWRALT 225


>UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LMR9_9FIRM
          Length = 239

 Score = 91.3 bits (225), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 60/186 (32%), Positives = 96/186 (51%), Gaps = 18/186 (9%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAGRLDRDSEGLLVLTN 90
           KPE  P R  LF+KP  V+   +D AGR+T+ ++     + V+  GRLD  SEGLL++TN
Sbjct: 58  KPE--PLRYYLFHKPDCVITSVSDPAGRRTVMDYFRRVRERVFPVGRLDYHSEGLLLVTN 115

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L   LT P     K Y V V G  ++   + +  GV ++ G T P   E++    + 
Sbjct: 116 DGQLDFILTHPCHEVQKEYEVVVRGKFSEKLAKKMEKGVKIDSGVTAPCEIEVL---GYD 172

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
             +N           + L++ L+EG+NR++R+M     +P   L R      +LD +  G
Sbjct: 173 AEKNK----------TRLRMVLHEGKNREIRKMMEIFHYPVFELKRIRYSFLTLD-VNRG 221

Query: 211 EWREVT 216
           ++R +T
Sbjct: 222 QYRRLT 227


>UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis excentricus CB 48
           RepID=C5SKU3_9CAUL
          Length = 489

 Score = 90.9 bits (224), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 65/187 (34%), Positives = 96/187 (51%), Gaps = 24/187 (12%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGAL 94
           +PTRV  ++KP  ++    D  GR T+   +P +   V + GRLD +SEGLL+LTN+G L
Sbjct: 103 EPTRVWRYHKPVGLMTTHQDPQGRPTVFNSLPQELPRVISVGRLDINSEGLLLLTNDGEL 162

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND---GP---TLPAGAELVDEPA 148
              L  P     ++Y V+  G  TQ+AL+ L+ GVT+     GP    L    E  D  A
Sbjct: 163 ARALELPTTGWTRVYRVRALGRTTQEALDTLKTGVTVEGVQYGPIEAKLDKAQEKADGRA 222

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
            L                W+ ++L EG+NR+VR++   +G    RLIR A G + L ++ 
Sbjct: 223 NL----------------WITVSLNEGKNREVRKVLDSLGLKVNRLIRLAYGPFQLGDIE 266

Query: 209 NGEWREV 215
            GE  E+
Sbjct: 267 PGEVEEI 273


>UniRef50_C5CGJ5 Pseudouridine synthase n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGJ5_KOSOT
          Length = 205

 Score = 90.9 bits (224), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 59/189 (31%), Positives = 94/189 (49%), Gaps = 20/189 (10%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLT 89
           +P  Q   V   NKP   L   +D+ GRKT+ + I     + V+  GRLD D+EGL++LT
Sbjct: 23  RPRKQQRVVYALNKPRGYLSSMSDDRGRKTIADLIKGKIPEKVFHVGRLDMDTEGLIILT 82

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPAGAELVDEPA 148
           N+G L  +L+ P  +  K Y  +V G  +   ++ L NGV L DG  T  A   ++    
Sbjct: 83  NDGELARKLSHPSSKIRKTYVARVTGKLSHHEIKRLENGVVLRDGFKTSGASIRVI---- 138

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                      R S+  + ++I ++EG  R++R M        L L R A+G   +D + 
Sbjct: 139 -----------RASLRDTLVEIIIHEGHKREIREMFKVFDKHVLYLKRTAIGSLKVDIVP 187

Query: 209 N-GEWREVT 216
           N G+ +++T
Sbjct: 188 NPGDIKKLT 196


>UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RK28_FIBSS
          Length = 243

 Score = 90.5 bits (223), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 63/204 (30%), Positives = 98/204 (48%), Gaps = 18/204 (8%)

Query: 19  HQVKRFSSQRSTRRK----PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGV 72
           HQV     Q +   K    P N+ T+VI+F+KP   +    D  GR+T+ +++P      
Sbjct: 39  HQVDETKDQVTVDGKLLKLPTNKKTKVIMFHKPAGCVCTKDDPQGRRTVYDYLPPGYHNF 98

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
              GRLD  S GLL+ T++G L  RLT P     + YYV      ++ A + L +GV + 
Sbjct: 99  KYVGRLDLQSRGLLLFTDDGELLYRLTHPSFEVPRSYYVWTTRPLSESAAQRLVDGVDIR 158

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
           D P  P   E +     ++  N            + ++ L EG+NR++RRM   +G+   
Sbjct: 159 D-PEDPDAQEEIAFATDVYLEN-----------GFAELVLIEGKNREIRRMMRAIGYEIR 206

Query: 193 RLIRYAMGDYSLDNLANGEWREVT 216
            L R +     L +L  GE+RE+T
Sbjct: 207 DLKRVSYCQIQLGDLPAGEFRELT 230


>UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vaginalis
           RepID=D2RB61_GARVA
          Length = 284

 Score = 90.5 bits (223), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 64/203 (31%), Positives = 93/203 (45%), Gaps = 31/203 (15%)

Query: 30  TRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYA 74
           TR  P+ Q  RV             +  +KP  VL    D  GR TL++ +    + ++ 
Sbjct: 84  TRVDPKRQKVRVDGSRVKFNTKLVTLALHKPKRVLSAMDDPKGRFTLRDIVGDKYERIFH 143

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG-IPTQDALEALRNGVTLND 133
            GRLD DSEGL+++TN+G L   +  P     K Y   VEG I        +  GV L D
Sbjct: 144 MGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATVEGKINGMVCRRLVSQGVNLED 203

Query: 134 GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLR 193
           G              W+      I ++    T+ +KI L+ G+NR VRR+   VGFP  R
Sbjct: 204 G--------------WIKLDRCAIIDQNH-DTTMVKIVLHSGKNRIVRRIFGAVGFPVKR 248

Query: 194 LIRYAMGDYSLDNLANGEWREVT 216
           L+R  +G   L +L  G +R ++
Sbjct: 249 LVRTQIGPIKLGDLKAGSYRVLS 271


>UniRef50_C1FHS6 Predicted protein (Fragment) n=4 Tax=Mamiellales RepID=C1FHS6_9CHLO
          Length = 248

 Score = 90.1 bits (222), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 66/180 (36%), Positives = 93/180 (51%), Gaps = 36/180 (20%)

Query: 44  FNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAA-----GRLDRDSEGLLVLTNNGALQARL 98
           +NKP  V    T E+ ++T     P +GV +A     GRLDRDS GL++LT++G +   L
Sbjct: 66  YNKPRGV--TCTMESSQRTK----PAKGVGSARVFPVGRLDRDSSGLVLLTDDGRVPEAL 119

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN-----DG-----PTLPAGAELVDEPA 148
             P ++  K Y V V   PT DA+EALR+GV +      DG     PT P   +L+    
Sbjct: 120 LDPSRKAPKTYEVDVRPAPTPDAIEALRDGVVITTTQQRDGVTTTSPTAPCPVDLI---- 175

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                      +KS  ++ L+  L EGRNRQ+R+M   VG   +RL R ++G   LD  A
Sbjct: 176 -----------KKSETSATLRFELREGRNRQIRKMCEAVGVEVVRLHRVSVGGVWLDESA 224


>UniRef50_A0CY18 Chromosome undetermined scaffold_30, whole genome shotgun sequence
           n=2 Tax=Paramecium tetraurelia RepID=A0CY18_PARTE
          Length = 337

 Score = 90.1 bits (222), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 59/192 (30%), Positives = 97/192 (50%), Gaps = 20/192 (10%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDS 82
           ++  + P  Q T+V +F KP  ++    D   R +  +F  +     Q + + GRLD +S
Sbjct: 86  KNGEKMPTKQSTKVWIFYKPVGMICSHNDPFKRPSFYDFAKLRLKTDQHIISVGRLDFNS 145

Query: 83  EGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAE 142
           EGL+V+TN+G L   +  P  +  +IY V+V G  T++ L+ +RNG+T+       AG  
Sbjct: 146 EGLIVVTNDGELARCMELPETKLQRIYRVRVYGTFTEEKLKKIRNGITI-------AGVN 198

Query: 143 LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
               P W+   N   R       +WL + L +G+NR++R++         RLIR + G Y
Sbjct: 199 Y--GPYWVNVENRQSR------NTWLIMRLEQGKNREIRKVMQKFDLRVNRLIRQSYGPY 250

Query: 203 SLDNLANGEWRE 214
            L  L  G++ E
Sbjct: 251 KLMGLKPGDFYE 262


>UniRef50_B3DRY9 Pseudouridine synthase n=7 Tax=Bifidobacterium RepID=B3DRY9_BIFLD
          Length = 256

 Score = 89.7 bits (221), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 62/204 (30%), Positives = 93/204 (45%), Gaps = 31/204 (15%)

Query: 26  SQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI--PVQ 70
           ++  TR  P  Q  RV             +  NKP  VL    D  GR TL++ +    +
Sbjct: 52  TELGTRVDPHKQQVRVDGSRVRVNPNHVTLALNKPRKVLSAMDDPKGRYTLRDIVGDKYE 111

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG-IPTQDALEALRNGV 129
            ++  GRLD DSEGL+++TN+G L   +  P     K Y   +EG I        +  GV
Sbjct: 112 RIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYVATLEGKISGTVCRRLVTTGV 171

Query: 130 TLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
            L+DG              W+   +  I +  S   + +K+ L+ G+NR VRR+   +GF
Sbjct: 172 QLDDG--------------WIKLDHCAIID-SSRDHTMVKVVLHSGKNRIVRRIFGSIGF 216

Query: 190 PTLRLIRYAMGDYSLDNLANGEWR 213
           P  RL+R  +G   L +L  G +R
Sbjct: 217 PVKRLVRTQIGPIKLGDLKPGSYR 240


>UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae RepID=B4RA72_PHEZH
          Length = 521

 Score = 89.4 bits (220), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 63/183 (34%), Positives = 96/183 (52%), Gaps = 13/183 (7%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           E +P RV  ++KP  ++    D  GR T+ E +P  +  + + GRLD +SEGLL+LTN+G
Sbjct: 206 EPEPVRVFRYHKPVGLVTTHKDPQGRPTVFEALPEGLPRLISVGRLDLNSEGLLLLTNDG 265

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L   L  P     + Y  +  G  TQ+ L+ L++G+T+ +G    A    +D+      
Sbjct: 266 GLARALELPATGVVRRYRARAHGRITQERLDTLKDGITV-EGVRYGAIEARLDK------ 318

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                +E       WL +TL EG+NR+VRR+   +G    RLIR + G ++L  L  GE 
Sbjct: 319 ----AKEGHQGANLWLTVTLQEGKNREVRRVLEALGLKVNRLIRLSYGPFALGTLDVGEI 374

Query: 213 REV 215
            EV
Sbjct: 375 EEV 377


>UniRef50_Q0F269 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F269_9PROT
          Length = 289

 Score = 89.4 bits (220), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 63/177 (35%), Positives = 86/177 (48%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           IL+NKP   L    D+  R  + +FI V   V + GRLD D+EGLL+LT++GAL   LT 
Sbjct: 105 ILYNKPKGQLCSRLDKKKRPLIYDFIDVAPNVQSIGRLDMDTEGLLMLTDDGALTRALTH 164

Query: 101 PGKRTGKIYYVQVEGIPTQDALEAL-RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           P  +  + Y  +V GI   + L  L R G+ +  G T  A    VD              
Sbjct: 165 PAAKVPREYRARVAGIVELETLAKLRRGGMDIGRGDTSDAWEVTVDS------------- 211

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
            +S   +WL I +  GR R+VRR     G P  RL+R   G   LD ++  G WR +
Sbjct: 212 -ESAGHTWLNIIILRGRWREVRRTLEECGHPVRRLMRTRFGPIKLDEDMPKGTWRAL 267


>UniRef50_C7NDY8 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NDY8_LEPBD
          Length = 228

 Score = 89.0 bits (219), Expect = 9e-17,   Method: Compositional matrix adjust.
 Identities = 54/176 (30%), Positives = 89/176 (50%), Gaps = 20/176 (11%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           + NKP  VL    D+ GR+   +FI  +  ++  GRLD  +EGL++++N+G +   +  P
Sbjct: 63  ILNKPKRVLCSNEDKFGRRLAVDFIKSRARLFTYGRLDFMTEGLIIISNDGEVYNHVMHP 122

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
            K+  K Y  +V        +EAL++GV ++   T PA                     K
Sbjct: 123 RKKLYKSYIAKVSREIEDKDIEALQHGVVIDGKRTAPAKV-------------------K 163

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            I    L+I ++EGRNRQ+R+M   +G+    L R  +G+ +L NL  GE+R + +
Sbjct: 164 KIDKKELRIAIFEGRNRQIRKMLETLGYNVNSLKRIKVGELTLGNLQVGEYRALNE 219


>UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZI67_9SPHI
          Length = 391

 Score = 89.0 bits (219), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 55/179 (30%), Positives = 92/179 (51%), Gaps = 20/179 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP D +    D   RKT+ + I     + +Y  GRLDR++ GLL+ TN+G +  +L
Sbjct: 220 VLLNKPKDFITTTNDPQDRKTVMDLIKNSCDERIYPVGRLDRNTTGLLLFTNDGEVAKKL 279

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           + P     K+Y V+++     + L+++  GV L D      G   VDE A L P      
Sbjct: 280 SHPSHDVKKVYQVELDKPLKDEDLDSIAEGVILED------GYAAVDEIAILNP------ 327

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           ER     + + + ++ GRNR VRR+  H+ +  ++L R      +  N+  G+WR +++
Sbjct: 328 ER-----TLVGVEIHIGRNRIVRRIFNHLDYEVVKLDRTMYAGLNKKNIDRGDWRYLSE 381


>UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IJT7_ACIBL
          Length = 680

 Score = 89.0 bits (219), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 64/188 (34%), Positives = 95/188 (50%), Gaps = 23/188 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEF---IPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L +KP   +   +D  GR+T+ +    IP + +Y  GRLD  SEGLL+LTN+G + A+L
Sbjct: 66  VLLHKPKGYVTTVSDPEGRETVMDLVKGIPAR-LYPVGRLDYLSEGLLLLTNDGEMAAKL 124

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T       K Y V+V G PT++ ++ LRNGV L      P    +  +P          R
Sbjct: 125 THASTHVPKKYLVKVSGEPTEEQIQELRNGVQL-----PPEQGHIHADPREGGRFGGEKR 179

Query: 159 ERKSIPTS-------------WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD 205
              ++ T+             W ++TL EGRNRQ+RRM   +G    ++ R   G   LD
Sbjct: 180 RSTAVKTAPCKIELTREGDNPWYEVTLNEGRNRQIRRMFDFIGHHVEKIKRVEYGPLKLD 239

Query: 206 NLANGEWR 213
            + NGE+R
Sbjct: 240 -VENGEFR 246


>UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q01SF5_SOLUE
          Length = 249

 Score = 89.0 bits (219), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 61/174 (35%), Positives = 81/174 (46%), Gaps = 18/174 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           I  NKP   +    D  GR+T+ + +    + VY  GRLD  SEGLL+LTN+G L   + 
Sbjct: 67  IALNKPKGTVTTVHDPEGRETVMDLLHRVKERVYPVGRLDYHSEGLLLLTNDGELANSIM 126

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
                  K Y V+V G  T +  E  R GV L+   TLPAG +L+         NP    
Sbjct: 127 SAATHLEKTYVVKVTGTLTAEQEEKFRTGVPLSGRRTLPAGLKLLSR-----AENP---- 177

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                  W ++ L EGRN Q+R M  H G    +L R  +G   L  L  G +R
Sbjct: 178 -------WYEVKLTEGRNNQIRMMFRHFGKLVEKLKRVRIGPIELGTLKTGAFR 224


>UniRef50_B1X5I1 Pseudouridine synthase, Rsu n=1 Tax=Paulinella chromatophora
           RepID=B1X5I1_PAUCH
          Length = 242

 Score = 89.0 bits (219), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 57/189 (30%), Positives = 91/189 (48%), Gaps = 22/189 (11%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLL 86
           R P+N  T  +L NKP  V+    D  GR T+ + IP      + ++  GRLD +S G L
Sbjct: 58  RLPDNHVT--LLINKPTGVISSCQDPQGRPTILDLIPQSILQNRKLHPIGRLDSNSRGAL 115

Query: 87  VLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE 146
           +LT +G+L   L+ P     K Y V VEG P+   ++  + G+ L+   T     +++  
Sbjct: 116 ILTTDGSLTMNLSHPRYSHDKAYKVWVEGRPSSSVIKIWQQGIFLDKKMTSRVELKILC- 174

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN 206
                         K + ++ L+I + EGR RQ+RR    +G P + L R  +    L +
Sbjct: 175 --------------KRVTSTLLEIVMKEGRKRQIRRTATFLGHPVIDLQRIGIASIRLGS 220

Query: 207 LANGEWREV 215
           L  G WR++
Sbjct: 221 LPEGRWRKL 229


>UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutactus ATCC 27759
           RepID=A8SYF2_9FIRM
          Length = 239

 Score = 88.6 bits (218), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 57/187 (30%), Positives = 87/187 (46%), Gaps = 29/187 (15%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTL--------KEFIPVQGVYAAGRLDRDSEGLLVLTNN 91
           R  L NKP   +    D   +  +        K+  PV      GRLD D+EGLL++TN+
Sbjct: 61  RYFLLNKPAGCVSATKDNVHQTVIDLLNGENTKDLFPV------GRLDLDTEGLLIITND 114

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL-NDGPTLPAGAELVDEPAWL 150
           G L   L  P     K YY  ++G      +   + G+ + +D PTLPA  ++       
Sbjct: 115 GRLAHHLLSPAHHIAKTYYADIDGYVDDQTISLFKQGIDIGDDTPTLPASLKI------- 167

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLAN 209
                 I   +S  +S +++T+ EGR  QV+RM   V      L R +MG+  + D+L  
Sbjct: 168 ------IEADRSTGSSRIELTITEGRFHQVKRMFQAVNMSVTFLKRISMGNLHIADDLPT 221

Query: 210 GEWREVT 216
           G +RE+T
Sbjct: 222 GSYRELT 228


>UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZE67_PLALI
          Length = 554

 Score = 88.6 bits (218), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 58/180 (32%), Positives = 91/180 (50%), Gaps = 17/180 (9%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           R  LF+KP  VL   +D AGR  + +  P  V  ++  GRLD  +EGLL++TN+G L  R
Sbjct: 97  RYFLFHKPAGVLCTNSDPAGRTRVIDCFPPNVGRLFTVGRLDDGTEGLLIVTNDGDLAER 156

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           LT P     +IY   V G P+ +A+  L  G+   +G                +  +   
Sbjct: 157 LTHPKFGIPRIYRAVVAGNPSTEAINQLLEGLYFAEG---------------RFRMSSVN 201

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R +     + L+IT+ EG+NR++RR+ A VG   ++L R   G   L +L  G  R++++
Sbjct: 202 RVKSQGSATVLEITMREGQNREIRRLLARVGHKVMKLKRTHFGPIKLGDLERGAHRKLSE 261


>UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredinis DSM 17216
           RepID=B0MSS4_9BACT
          Length = 451

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 59/185 (31%), Positives = 92/185 (49%), Gaps = 20/185 (10%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNN 91
           E +    ++ NKP   +    D    KT+ E +     + +Y  GRLD++S GLL+ TN+
Sbjct: 271 EGEKKVYLVLNKPKGYVTSLDDPHADKTVMELVKDACTERIYPVGRLDKNSVGLLLFTND 330

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L  +LT P  +  KIY V ++   T+  +E +  G+TL DG          DE A+  
Sbjct: 331 GDLTRQLTHPSFQKKKIYQVSLDKPLTKADMEQIAQGITLEDGEI------YADEIAY-- 382

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                ++E K    + + I ++ GRNR VRR+  H+G+   +L R      S  NL  G+
Sbjct: 383 -----VKEDK----TEVGIEIHSGRNRIVRRIFEHLGYAVKKLDRVYYAGLSKKNLKRGQ 433

Query: 212 WREVT 216
           WR +T
Sbjct: 434 WRFLT 438


>UniRef50_B6W7S5 Pseudouridine synthase n=2 Tax=Anaerococcus RepID=B6W7S5_9FIRM
          Length = 231

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 49/175 (28%), Positives = 86/175 (49%), Gaps = 19/175 (10%)

Query: 44  FNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPG 102
            NKP   +    D   +K L   + +    + AGRLD+DS GL+++TN+G +  +L  P 
Sbjct: 64  LNKPIGFISSNYDPHNKKDLNSLVKIDHRFFCAGRLDKDSHGLMLITNDGKITNKLIHPS 123

Query: 103 KRTGKIYYVQVEGIPTQDALEALRNGVTLN-DGPTLPAGAELVDEPAWLWPRNPPIRERK 161
           K+  K Y V+V+ +  +D     R G+ L+ +  T  A   L+DE + ++          
Sbjct: 124 KKIEKTYIVKVDKLLNKDDEALFRKGIKLSVNEKTSDAKINLIDENSKIYE--------- 174

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                   + +++G NRQVRRM  + G   + L R  +G   L  L +G+++++ 
Sbjct: 175 --------VIIHQGFNRQVRRMFLYFGSKVIDLKRIKIGQIELGKLEDGKYKKLN 221


>UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae RepID=C6VP86_LACPJ
          Length = 246

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 60/180 (33%), Positives = 89/180 (49%), Gaps = 18/180 (10%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + NKP  V+   TD A +  +  F        ++  GRLD+D+EG+LV+TN+GAL   L 
Sbjct: 64  VMNKPVGVITATTDSAAKTVMDLFNTTDFRDDLFPVGRLDKDTEGILVITNDGALSHDLL 123

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWPRNPPIR 158
            P     K+Y  +V G  T   L    +G+TL DG  L PA AE+V              
Sbjct: 124 SPNHHVTKVYEAEVTGEITAAQLANFNDGITLKDGTELQPAQAEIV-----------QFH 172

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
           E ++  T  ++I ++EG+  QV+RM   +G   + L R   G  +L   L  G +R +TD
Sbjct: 173 EIENFTT--IRIMIHEGKYHQVKRMVGTLGERVVGLRRIKFGSLTLPVGLLAGNYRALTD 230


>UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacteria
           RepID=Q0G3T3_9RHIZ
          Length = 639

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 63/184 (34%), Positives = 96/184 (52%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           P+ + TR+ LF+KP   +    D  GR+T+ + +P  +  V + GRLD ++EGLL+LTN+
Sbjct: 238 PQAERTRLWLFHKPAGTVTTNKDPEGRRTVFDMLPEDMPRVLSIGRLDINTEGLLLLTND 297

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   L  P     + Y V+  G  TQ  L+ LRNG+++ DG    A    +D      
Sbjct: 298 GGLSRVLELPSTGWLRRYRVRAHGSITQAKLDELRNGISV-DGVFYGAIEATLD------ 350

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                   R+     W+ + L EG+NR+V+ +   +G    RLIR + G + L +LA G 
Sbjct: 351 --------REQGSNVWITLGLREGKNREVKNVLGALGLEVNRLIRLSYGPFQLGDLAEGS 402

Query: 212 WREV 215
            REV
Sbjct: 403 VREV 406


>UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine synthase A n=3
           Tax=Fusobacterium RepID=UPI0001BC42E2
          Length = 235

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 52/142 (36%), Positives = 75/142 (52%), Gaps = 19/142 (13%)

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
            GRLD+D+EGLL+ TN+G L  RL  P     K Y+  +E   T++ALE LR GV + + 
Sbjct: 99  VGRLDKDTEGLLLFTNDGKLNHRLLSPKSHVDKTYHASLECDITEEALEKLREGVMIGEY 158

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
            TLPA AE              + +RK      + +T+ EG+  QV++M   VG   + L
Sbjct: 159 KTLPAKAE-------------KLEDRK------IALTIREGKFHQVKKMLEAVGNKVIYL 199

Query: 195 IRYAMGDYSLDNLANGEWREVT 216
            R + G   L +L  GE +EV+
Sbjct: 200 KRISFGKLVLGDLELGEVKEVS 221


>UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BMY5_9LACT
          Length = 237

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 58/184 (31%), Positives = 91/184 (49%), Gaps = 21/184 (11%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           E+   +  L NKP  V+   TD      +  F    ++G+Y  GRLDRD+EGLL++TNNG
Sbjct: 56  EDNSQKYYLLNKPKGVITATTDSQLPTVIDLFKNENIEGLYPIGRLDRDTEGLLIITNNG 115

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-PAGAELVD-EPAWL 150
            L  RL  P +   K YYV+V G      ++   +G+  +DG    PA   +++  P++ 
Sbjct: 116 PLGYRLLNPIQHIEKEYYVEVNGPLDNSCIQRFYDGIMFHDGTICKPAKLSILESSPSF- 174

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLAN 209
                          S   +T+ EG+  Q+++M   VG     L R   G++ LD +L+ 
Sbjct: 175 ---------------SKATVTISEGKFHQIKKMFLCVGVKVTFLKRIRFGEFLLDESLSP 219

Query: 210 GEWR 213
           GE+R
Sbjct: 220 GEYR 223


>UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae RepID=Q2K4S3_RHIEC
          Length = 312

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 57/179 (31%), Positives = 89/179 (49%), Gaps = 18/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           ++ NKP  ++    D  GR T+ + +    +  +   GRLD+ SEGLL+ TN+      L
Sbjct: 132 LMLNKPRGLVTTRQDPEGRPTVYDCLKNFDIPHLSPVGRLDKASEGLLLFTNDTEFAQTL 191

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K Y+VQ++ +   + + A+ +G+  +DG  L A A                R
Sbjct: 192 LDPLTHVTKTYHVQIDRLMDDEEIAAMTSGIR-HDGELLTAAATR--------------R 236

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            R+    SW+++ L EGRNRQ+RRM   +G   LRL+R A+G   L  L  G  R +T+
Sbjct: 237 LRQGDRNSWIEVELDEGRNRQIRRMLEALGAECLRLVRVAIGGLELGELPKGAVRALTE 295


>UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R892_9RHOB
          Length = 681

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 63/184 (34%), Positives = 95/184 (51%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           P  + TR+ LF+KP   +    D  GRKT+ + +P  +  V   GRLD ++EGLL+LTN+
Sbjct: 91  PTRERTRLWLFHKPRGTVTTNKDPEGRKTVFDILPKDMPRVVTVGRLDINTEGLLLLTND 150

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   +  P     + Y V+  G  TQ+ L+AL++GV + DG    A    +D      
Sbjct: 151 GGLSRVIELPATGWLRRYRVRAFGKVTQEQLDALKDGVAI-DGVLYGAIEATLDT----- 204

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                    +     WL I L EG+NR+V+R+  H+     RLIR + G + L +L  GE
Sbjct: 205 ---------EKGDNVWLTIGLREGKNREVKRILEHLDLSVNRLIRISFGPFQLGDLGEGE 255

Query: 212 WREV 215
            +E+
Sbjct: 256 LQEI 259


>UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MA52_9PORP
          Length = 472

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 53/178 (29%), Positives = 88/178 (49%), Gaps = 19/178 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP + +   TD  GR+T+ + +     + +Y  GRLDR++ G+L+LTN+G L  RL
Sbjct: 267 VLLNKPKNCVTTLTDPEGRRTVMDLVHNACTERIYPIGRLDRNTTGILLLTNDGDLAVRL 326

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P  R  KIY V ++   T + ++ + +G  L DG          D  +++  +     
Sbjct: 327 MHPAFRKKKIYEVALDKEVTVEHMQMIAHGFELEDGEIH------ADAISYITGQT---- 376

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                    + I ++ GRNR VRR+  H+G+  + L R      +  +L  G WR +T
Sbjct: 377 ------HDKVGIEIHSGRNRIVRRIFEHLGYRVVHLDRVYYAGLTKKDLPRGRWRYLT 428


>UniRef50_Q3Z8C8 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=Q3Z8C8_DEHE1
          Length = 249

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 61/180 (33%), Positives = 95/180 (52%), Gaps = 22/180 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQAR 97
           ++ NKP +++   +DE GRKT+ + +  +    G++  GRLD  + GLL+LTN+G L  R
Sbjct: 73  LMLNKPPEIVSTTSDELGRKTVMDLLHRRYEGAGLFPVGRLDETTTGLLLLTNDGELTNR 132

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAG-AELVDEPAWLWPRNPP 156
           LT P     K Y + ++   TQ   E+L  G+ L+DG T PA  + + DEP + +     
Sbjct: 133 LTHPSYEIEKEYLISIDAALTQADKESLEKGMLLDDGLTSPARLSRVTDEPPYNY----- 187

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                       K+ ++EG+ R VRRM AH+G+    L R  +    L  L  G+ RE+T
Sbjct: 188 ------------KLIIHEGKKRIVRRMFAHLGYQIKALKRSRIATLRLGKLEEGKTRELT 235


>UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indica subsp. indica
           ATCC 9039 RepID=B2IHU4_BEII9
          Length = 528

 Score = 87.8 bits (216), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 62/182 (34%), Positives = 96/182 (52%), Gaps = 20/182 (10%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFI-----PVQGVYAAGRLDRDSEGLLVLTNNGA 93
           TR+ LF+KP  ++    D  GR T+ +++      +  V + GRLD ++EGLL+LTN+G 
Sbjct: 149 TRLFLFHKPRGLVTTNHDPEGRPTVFDYLHERHPDMPRVLSIGRLDINTEGLLLLTNDGG 208

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L   L  P     + Y V+ +G   Q  L+ LR G+T+ DG    AG E+          
Sbjct: 209 LSRLLELPTTGWVRRYRVRAKGTTDQAVLDQLRQGITI-DGIHY-AGMEVT--------- 257

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                +R+    SWL ++L EG+NR+V+R+   +G    RLIR + G + L +L  G+  
Sbjct: 258 ----FDREQGANSWLTLSLREGKNREVKRVLEQIGLEVNRLIRLSFGPFQLGDLPEGDVT 313

Query: 214 EV 215
           EV
Sbjct: 314 EV 315


>UniRef50_Q9I5J6 Ribosomal small subunit pseudouridine synthase A n=25
           Tax=Gammaproteobacteria RepID=RSUA_PSEAE
          Length = 230

 Score = 87.4 bits (215), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 66/201 (32%), Positives = 93/201 (46%), Gaps = 23/201 (11%)

Query: 18  NHQVKRFSS-QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVY 73
            H+V+ FS  +   R     +P R  + +KP   +   T +    T+ +  P      ++
Sbjct: 38  THEVRVFSRVELDERLLQAGKPARYYMLHKPMGCVSA-TRDPQHPTVLDLFPEDLRDDLH 96

Query: 74  AAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND 133
             GRLD ++ GL++LTN+G    RLT PG R  K+YYV+ E    Q  ++A   G+    
Sbjct: 97  IGGRLDYNTTGLMLLTNDGQWSRRLTLPGSRRDKVYYVETEAPIDQRYVDAFAAGLHFR- 155

Query: 134 GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLR 193
                   +LV  PA L P  P             ++TL+EGR  QV+RM  H     LR
Sbjct: 156 ------FEDLVTLPAQLEPIGP----------RCARLTLHEGRYHQVKRMFGHFDNKVLR 199

Query: 194 LIRYAMGDYSLD-NLANGEWR 213
           L R  MGD  LD  L  G WR
Sbjct: 200 LHRERMGDICLDPQLPPGAWR 220


>UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gingivalis ATCC 33277
           RepID=B2RK43_PORG3
          Length = 439

 Score = 87.0 bits (214), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 51/175 (29%), Positives = 87/175 (49%), Gaps = 19/175 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP + +    D   R T+ + +     + +Y  GRLDR++ G+L++TN+G L ++L
Sbjct: 265 VLLNKPKNCVTTSDDPECRTTVMDIVRYACPERIYPVGRLDRNTTGVLLITNDGDLASKL 324

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P  +  KIY+V +    + + ++ + +GV L+DG         V E            
Sbjct: 325 THPSFKKKKIYHVWLNKDVSIEDMQKIADGVELDDGEIHADAISYVKEDDL--------- 375

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                  S + I ++ GRNR VRR+  H+G+  ++L R      +  NL  G+WR
Sbjct: 376 -------SQVGIEIHSGRNRIVRRLFEHLGYRVVKLDRVYFAGLTKKNLPRGKWR 423


>UniRef50_D2UX35 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UX35_NAEGR
          Length = 362

 Score = 87.0 bits (214), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 55/179 (30%), Positives = 92/179 (51%), Gaps = 19/179 (10%)

Query: 39  TRVILFNKPYDVLPQFTDEAG-RKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGAL 94
            ++  ++KP  VL    D  G R+T+ + +   G   + + GRLD +SEGL++LTN+G L
Sbjct: 149 VKLYAYHKPRGVLCSRVDNGGNRETIYQRLERMGFGHLISVGRLDYNSEGLILLTNDGNL 208

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              L  P     + Y V+V G  +Q  L++L+ G T+        G       A L    
Sbjct: 209 SRHLELPQTGLERQYLVRVHGQVSQPLLDSLQKGSTI-------EGVHYAGMKATLH--- 258

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                R+   TSW+K+ L+EG+NR++R++   +  P  R++R   G Y L+N+  G+ +
Sbjct: 259 -----REGEKTSWIKVILHEGKNREIRKIFQQLNLPVSRIMRIQYGPYKLENIQKGQIK 312


>UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae RepID=C6AV89_RHILS
          Length = 268

 Score = 87.0 bits (214), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 58/179 (32%), Positives = 88/179 (49%), Gaps = 18/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           ++ NKP  ++    D  GR T+ + +    +  +   GRLD+ SEGLL+ TN+      L
Sbjct: 87  LMLNKPRGLVTTRHDPEGRPTVYDCLRDFDIPHLSPVGRLDKASEGLLLFTNDTEFAQIL 146

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K Y+VQ++ I   + + A+  G+  +DG  L A A                R
Sbjct: 147 LDPVTHVTKTYHVQIDRIMDDEDIAAMTAGIR-HDGELLTATAAR--------------R 191

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            R+    SW+++ L EGRNRQ+RRM   +G   LRL+R A+G   L  L  G  R +T+
Sbjct: 192 LRQGDRNSWIEVELDEGRNRQIRRMLEALGTECLRLVRVAIGGLELGELPKGAVRALTE 250


>UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A4SY81_POLSQ
          Length = 587

 Score = 86.7 bits (213), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 65/197 (32%), Positives = 96/197 (48%), Gaps = 29/197 (14%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVY-AAGRLDRDSEG 84
           +   RK + +P RVI+++KP   +   +D  GR T+ + +P   QG + A GRLD ++EG
Sbjct: 247 KPVHRKIQTKPPRVIMYHKPAGEIVSQSDPEGRPTVFDRLPKPRQGRWIAVGRLDFNTEG 306

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT-----LPA 139
           LL+ T +G L  RL  P     + Y V++ G  +Q+    L++G+TL+DG          
Sbjct: 307 LLLFTTSGELANRLMHPRYGVEREYAVRILGDLSQENTALLKSGITLDDGQAKFLRLAMG 366

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
           G E  +                     W  + L EGRNR+VRRM   VG    RLIR   
Sbjct: 367 GGEGANR--------------------WYHVALSEGRNREVRRMFEAVGHTVSRLIRTRY 406

Query: 200 GDYSL-DNLANGEWREV 215
           G + L   L  G+W E+
Sbjct: 407 GIFLLPPRLRRGKWEEI 423


>UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PP04_CHIPD
          Length = 516

 Score = 86.7 bits (213), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 59/181 (32%), Positives = 88/181 (48%), Gaps = 21/181 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI-----PVQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           IL NKP   +    D  GRKT+ E I       Q VY  GRLDR++ GLL+LTN+G L  
Sbjct: 342 ILLNKPKGYITTTDDPEGRKTVMELIQDATTEEQRVYPVGRLDRNTSGLLLLTNDGELAQ 401

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           +L  P     KIY+V +    T+   E +  GVTL DG         VD   ++      
Sbjct: 402 KLAHPKHNIKKIYHVGLNKPLTKAHFENILQGVTLEDG------VANVDALGYV------ 449

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
               ++   + + I ++ G+NR VRR+  H+ +   +L R      +  N+  G+WR +T
Sbjct: 450 ----EAGDKTQVGIEIHSGKNRIVRRIFEHLEYEVEKLDRVTYAGLTKKNINRGKWRFLT 505

Query: 217 D 217
           +
Sbjct: 506 E 506


>UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepID=A2RP35_LACLM
          Length = 328

 Score = 86.3 bits (212), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 12/178 (6%)

Query: 43  LFNKPYDVLPQFTDEAGR---KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           L NKP  V+    D   +   + L E    + ++  GRLD+++EGLL+LTN+GAL   LT
Sbjct: 150 LLNKPQGVVSATKDNVFKTVVQLLSEKDFRKDIFPVGRLDKNTEGLLILTNDGALGHDLT 209

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           QP K   K Y+ +++G  T + +     G+TL +G            P  L+       +
Sbjct: 210 QPKKHVEKEYFARIDGKVTDEIINKFAEGLTLKNGEKA--------RPGELFVEKTYKGD 261

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            +S   S +++ ++EG+  QV+RM   V    L L R  MG+ +LD +LA G +R +T
Sbjct: 262 SQSGWVSEIRVIIHEGKFHQVKRMFEAVEMYVLYLKRIRMGNLALDSDLALGAYRPLT 319


>UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C7M7R0_CAPOD
          Length = 387

 Score = 86.3 bits (212), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 57/178 (32%), Positives = 87/178 (48%), Gaps = 19/178 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARL 98
           IL NKP   +    DE GRKT+ + +       +   GRLDR + GLL+LTN+G L  +L
Sbjct: 215 ILLNKPKGFITTTNDEKGRKTVMDLVANATNVRILPVGRLDRATTGLLLLTNDGELTKKL 274

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     KIY+V +      D     ++ + + DG  L  G   VDE +++  +     
Sbjct: 275 THPTHGVRKIYHVIL------DRKLDYKDFMKVQDGLELEDGLIEVDEISYVNDK----- 323

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                P + + I ++ GRNR VRR+  H+G+   +L R      +  +L  G WR +T
Sbjct: 324 -----PKNEIGIKIHSGRNRIVRRIFEHLGYQVEKLDRVVFAGLTKKDLPRGHWRRLT 376


>UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas RepID=B4W9R3_9CAUL
          Length = 519

 Score = 86.3 bits (212), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 66/191 (34%), Positives = 95/191 (49%), Gaps = 28/191 (14%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGAL 94
           Q TRV  ++KP  +L   +D  GR T+ + +P  +  V + GRLD  +EGLL+LTN+G L
Sbjct: 143 QATRVWRYHKPAGLLTSHSDPTGRPTVFDALPAGLPRVISVGRLDLATEGLLLLTNDGEL 202

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND---GP---TLPAGAELVDE-- 146
              L  P     + Y  +  G  TQ+ L+ L++GV ++    GP   TL    E   E  
Sbjct: 203 SRALELPATSLVRQYRARARGKITQEQLDKLKDGVVVDGVSYGPIEATLDKAKESKSEDG 262

Query: 147 --PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
             PA L                W+ +++ EG+NR+VR++   VG    RLIR A G + L
Sbjct: 263 RAPANL----------------WISVSITEGKNREVRKVLESVGLTVNRLIRLAYGPFRL 306

Query: 205 DNLANGEWREV 215
           D L  G   EV
Sbjct: 307 DVLPIGSVEEV 317


>UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FUC8_9FIRM
          Length = 243

 Score = 85.9 bits (211), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 59/179 (32%), Positives = 87/179 (48%), Gaps = 17/179 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKT---LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           L NKP  +L    D   +     L E      ++  GRLD D+ GLL+LTNNG L  +L 
Sbjct: 64  LLNKPEGILSATEDRHHQTVIDWLGEGYQHLDLFPVGRLDIDTTGLLLLTNNGQLAHQLL 123

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P K+  K Y   + G+  Q  + A   G+ L D  +LPA   ++ +             
Sbjct: 124 SPKKKVDKTYTATIRGLVDQADIAAFEAGLDLGDFTSLPAELTVLSQDV----------- 172

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
                TS +++ + EG+  QV+RM   VG   L L R AMG   L+ +LA+G+WR +T+
Sbjct: 173 --DQGTSQIQVIIQEGKFHQVKRMFQAVGKEVLSLHRLAMGPLRLESDLAHGQWRSLTE 229


>UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrionales
           RepID=C4XSY8_DESMR
          Length = 322

 Score = 85.9 bits (211), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 67/184 (36%), Positives = 95/184 (51%), Gaps = 20/184 (10%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGA 93
           P  + L  KP  V+   +D  GR T+ + +P     + ++  GRLD  SEGLL+LT +G 
Sbjct: 70  PITLALHKKP-GVVTTASDPEGRPTVFDGLPEVWRGKRLFPVGRLDFFSEGLLLLTTDGE 128

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWP 152
           L  RLT P     K Y V V G  T D L  +  G+ L +G  L P  A +V+ PA    
Sbjct: 129 LALRLTHPRWHVPKRYRVTVRGQVTPDMLGTMARGMRLAEGERLAPVAARVVEGPA---- 184

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                 + +SI    L++ L++G NRQ+RRM   +G   LRL R + G  +L +L  G  
Sbjct: 185 ------QDRSI----LEMELHQGVNRQIRRMCRDLGLTVLRLARVSQGPVALGDLPLGAC 234

Query: 213 REVT 216
           RE+T
Sbjct: 235 RELT 238


>UniRef50_A1K3P0 Pseudouridylate synthase n=3 Tax=Betaproteobacteria
           RepID=A1K3P0_AZOSB
          Length = 500

 Score = 85.9 bits (211), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 59/160 (36%), Positives = 78/160 (48%), Gaps = 21/160 (13%)

Query: 60  RKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           R   + F P Q  G+  AGRLD DS GLLVLT +G +  +L     +  K Y V+VEG  
Sbjct: 356 RDVAQRFHPSQLKGLAPAGRLDIDSTGLLVLTQDGRIARQLIGDDSKVEKEYLVRVEGEL 415

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
             D L  L +G++L+D P  PA  E ++E                     L+  L EGR 
Sbjct: 416 VDDGLALLNHGLSLDDKPLRPAKVEWINE-------------------DQLRFVLKEGRK 456

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RQ+RRM   VG   + L R  +G   L +L  GEWR + D
Sbjct: 457 RQIRRMCELVGLRVVGLKRVRIGRVKLGDLPLGEWRYLRD 496


>UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alexandrii HTCC2633
           RepID=A3UFV9_9RHOB
          Length = 354

 Score = 85.9 bits (211), Expect = 9e-16,   Method: Compositional matrix adjust.
 Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 17/179 (9%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQ 95
           PTRV  ++KP  +L   +D  GR T+ + +P  +  V + GRLD +SEGLL+LTN+G L 
Sbjct: 75  PTRVWRYHKPVGLLTTHSDPQGRDTVFQTLPQDMGRVISVGRLDLNSEGLLLLTNDGELA 134

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
             L  P     + Y V+  G  +  AL  L NG T+ DG         VD          
Sbjct: 135 RVLELPSTGWTRRYRVRAYGNASDKALAELENG-TVVDGVVYGPVEVTVD---------- 183

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
               R++    WL + + EG+NR+VR++   VG    RL+R A G + L +L  GE  E
Sbjct: 184 ----RRTGANVWLTVGIKEGKNREVRKVLQSVGLTVNRLMRVAYGPFQLGSLKRGEISE 238


>UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria RepID=Q140U9_BURXL
          Length = 633

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 66/192 (34%), Positives = 93/192 (48%), Gaps = 21/192 (10%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV---YAAGRLDRDSEGLLV 87
           +RK  ++P RV+L++KP   +    D  GR ++ + +P        A GRLD ++EGLL+
Sbjct: 270 KRKLASKPPRVLLYHKPTGEIVSHADPEGRPSVFDKLPPMKTAKWLAVGRLDFNTEGLLM 329

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEP 147
           LT +G L  R   P     + Y V+V G   +   + L +GV L+DGP            
Sbjct: 330 LTTSGDLANRFMHPRYSVEREYAVRVVGELAEGMRQKLLHGVELDDGPA----------- 378

Query: 148 AWLWPRNPPIRERKSIPTS-WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-D 205
            +L      IR+     T+ W  + L EGRNR+VRRM    G    RLIR   G  SL  
Sbjct: 379 NFLR-----IRDGGGEGTNHWYHVALAEGRNREVRRMFEAAGLMVSRLIRTRHGPISLPK 433

Query: 206 NLANGEWREVTD 217
            L  G W E+ D
Sbjct: 434 GLKRGRWEELED 445


>UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID=B2TQQ1_CLOBB
          Length = 264

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 55/184 (29%), Positives = 95/184 (51%), Gaps = 12/184 (6%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           +FNKP   +    D   R     F   + GV+  GRLD+D+EGLL+LTN+G  + ++  P
Sbjct: 64  MFNKPSGCITATKDNIHRTVFDYFDEDMNGVFHVGRLDKDTEGLLLLTNDGEFEHKVMHP 123

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTL--NDGPTLPAGAELVDEPAWL-WPRNPPI- 157
            K   K Y+    G    +  + L+ GV +  N+  T PA  ++    +++ +    PI 
Sbjct: 124 EKHVEKTYFFWALGSLDDEDKKQLQEGVFIGSNEALTKPAKIDIHKSGSYIEFKEEIPIN 183

Query: 158 ----RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEW 212
               ++ + + + +L  T+ EG+  QV+RM   VG   + L R ++G   LD +L  G++
Sbjct: 184 SLKNKDHQPVVSGYL--TISEGQKHQVKRMLKAVGCYVIYLKRISIGGLKLDESLKMGDY 241

Query: 213 REVT 216
           R++T
Sbjct: 242 RDLT 245


>UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C4Z9Y4_EUBR3
          Length = 250

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 60/179 (33%), Positives = 91/179 (50%), Gaps = 22/179 (12%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           LFNKP   +    D     T+ ++I       ++  GRLD D+EGLL++TN+GAL   L 
Sbjct: 75  LFNKPSGCVSATCDNV-HDTVMDYITDAVHDDLFPVGRLDIDTEGLLLITNDGALSHELL 133

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P K   K YY +++G  T D +   + G+ +  + PT P  AELV              
Sbjct: 134 SPSKHVAKTYYARIDGEVTLDDIIRFKEGIDIGEEKPTKP--AELV-------------- 177

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
            +KS   S +++T+ EG+  QV+RM   +G   + L R +MG   L D+L  G +R +T
Sbjct: 178 IKKSGSVSEIELTITEGKFHQVKRMFEALGKRVIYLKRISMGPLKLPDDLKTGTYRALT 236


>UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ATCC 33270
           RepID=A8SLU4_9FIRM
          Length = 230

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 50/145 (34%), Positives = 74/145 (51%), Gaps = 17/145 (11%)

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +Y  GRLD+DS GLL+LTN+G L  RLT P     K Y V+V+    +  L+ L +G+ L
Sbjct: 93  IYPVGRLDKDSFGLLLLTNDGDLAFRLTHPSHNVEKEYIVKVDKTLKESDLKKLSSGIML 152

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
               T  A  E++D                   ++ +K+ L EGRNRQ+R+M   + +  
Sbjct: 153 EGKITRKARFEMLD-----------------FKSNIVKVFLKEGRNRQIRKMFKTLDYNV 195

Query: 192 LRLIRYAMGDYSLDNLANGEWREVT 216
           + L R A G   L  L  G +RE++
Sbjct: 196 ISLERIAFGKIKLGKLKVGNYRELS 220


>UniRef50_C6VS09 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6VS09_DYAFD
          Length = 225

 Score = 85.1 bits (209), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 60/188 (31%), Positives = 92/188 (48%), Gaps = 11/188 (5%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKE--FIPVQGVYAAGRLDRDSEGLLVLTNNGALQ 95
           P R  + NKP +++ QF      + L E  F   +G +A GRLD  SEGLL+LT N  + 
Sbjct: 9   PHRYFIINKPPNMVSQFVSSHDVRLLGELDFDFPEGTHAVGRLDSMSEGLLILTTNKKVT 68

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-----PTLPAGAELVDEPAWL 150
             L        + Y+V V  I   + ++ LR G+ +         T P   E+++ PA L
Sbjct: 69  NLLFLGEVPHTRTYWVNVGHIVPPETVQLLRTGIPIRVKGGGYYTTAPCEVEVIERPAIL 128

Query: 151 -WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
            W ++     +  +P +WL ITL EG+  QVR+M         RL+R ++ D  L +L  
Sbjct: 129 PWHQS---EGQPGVPNTWLSITLTEGKYHQVRKMVREANHRCKRLVRASIEDLELGDLPP 185

Query: 210 GEWREVTD 217
           G  RE+ +
Sbjct: 186 GGVREIGE 193


>UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72 RepID=A1K7C2_AZOSB
          Length = 356

 Score = 85.1 bits (209), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 29/187 (15%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVY-AAGRLDRDSEGLLVLTNNGALQA 96
           RV++++KP   +    D  GR T+ E +P+  +G + A GRLD ++ GLL+ TN+G L  
Sbjct: 153 RVLVYHKPEGEIVSRDDPEGRPTVFERLPLLRKGRWLAVGRLDFNTSGLLLFTNDGDLAN 212

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT-----LPAGAELVDEPAWLW 151
           RL  P     + Y V++ G  T++  ++L +G+ L DGP      + AG E V+      
Sbjct: 213 RLMHPRYELTREYAVRLLGQLTEEQGQSLVDGIQLEDGPARFLSLVDAGGEGVNH----- 267

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANG 210
                          W ++TL EGRNR+VRRM   VG    RL+R   G   L   L  G
Sbjct: 268 ---------------WYRVTLAEGRNREVRRMFEAVGLTVSRLMRVRYGPVELPARLKRG 312

Query: 211 EWREVTD 217
            W E+ +
Sbjct: 313 MWMELPE 319


>UniRef50_O05668 Uncharacterized RNA pseudouridine synthase ML1370 n=49
           Tax=Actinomycetales RepID=Y1370_MYCLE
          Length = 256

 Score = 85.1 bits (209), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 58/178 (32%), Positives = 87/178 (48%), Gaps = 22/178 (12%)

Query: 44  FNKPYDVLPQFTDEAGRKTLKEFIP--VQG---VYAAGRLDRDSEGLLVLTNNGALQARL 98
            NKP  +    +D+ GR  + + I   V+G   ++  GRLD D+EGL++LTN+G L  RL
Sbjct: 81  LNKPRGMYSTMSDDRGRPCVGDLIERRVRGNKKLFHVGRLDADTEGLILLTNDGELAHRL 140

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K Y   V+G   +   + L  G+ L+DGP       +VD             
Sbjct: 141 MHPSHEVSKTYLATVKGAVPRGLGKKLSVGLELDDGPAHVDDFAVVD------------- 187

Query: 159 ERKSIP-TSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
              +IP  + +++TL+EGR R VRR+    GFP   L+R  +G  SL +   G  R +
Sbjct: 188 ---AIPGKTLVRLTLHEGRKRIVRRLLTAAGFPVEMLVRTDIGAVSLGDQRPGCLRAL 242


>UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales RepID=B1C6T1_9FIRM
          Length = 238

 Score = 85.1 bits (209), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 17/176 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           + NKP  V+     + G +T+ + +  +   ++  GRLD+D+ GL++LTN+G    +LT 
Sbjct: 69  MLNKPQGVISASKSKYGEETVVDLLGKKEHRLFPVGRLDKDTTGLIILTNDGDFAYKLTH 128

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y   V+G     +L+ L+ GV ++   T  A   LV                
Sbjct: 129 PKYEKEKTYEALVKGKVDSKSLDKLKQGVVIDGKKTSRAKVRLVKMIGV----------- 177

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                S ++ITL EGR RQV++M   VG   ++L R      SL +L  GE+R++T
Sbjct: 178 ----NSLVEITLIEGRKRQVKKMCEKVGHKVIKLNRTMENGLSLGDLEIGEYRKLT 229


>UniRef50_Q0AS26 Pseudouridine synthase n=1 Tax=Maricaulis maris MCS10
           RepID=Q0AS26_MARMM
          Length = 372

 Score = 85.1 bits (209), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 61/179 (34%), Positives = 91/179 (50%), Gaps = 17/179 (9%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           T++  ++KP  ++    D  GR+T+ + IP  +  V + GRLD  SEGLL+LTN+GAL  
Sbjct: 68  TKLWRYHKPDGLVTTHADPEGRETVFDAIPKDIGRVISIGRLDLTSEGLLLLTNDGALAR 127

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
            L  P     + Y  +  G  ++ AL+ LR GVT+      P   E+             
Sbjct: 128 ALELPSTGWTRRYRARAFGSISESALKILRAGVTVEGIKYGPMEVEV------------- 174

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
             ER++    WL++ + EG+NR+VR+    VG    RLIR A G + L  L  GE + V
Sbjct: 175 --ERETGSNIWLEVGIREGKNREVRKALDAVGLRVNRLIRIAYGPFQLGQLEKGEIKSV 231


>UniRef50_A5CX60 Pseudouridine synthase n=1 Tax=Candidatus Vesicomyosocius okutanii
           HA RepID=A5CX60_VESOH
          Length = 241

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 57/178 (32%), Positives = 84/178 (47%), Gaps = 17/178 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVY-AAGRLDRDSEGLLVLTNNGALQ 95
           Q T+VI+ NK   V+    D+ GRK++   +P +  +   GRLD ++ GLL++TNNG L 
Sbjct: 63  QETKVIILNKQAGVICSNRDDKGRKSVYSLLPKESRWIMVGRLDLNTSGLLLVTNNGDLA 122

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
            +L  P     + Y V+V G      L+ L  GV  +DG +                 N 
Sbjct: 123 NKLMHPSSEIDREYAVRVLGQVKNKDLKKLTQGVVFDDGFS---------------KFNQ 167

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEW 212
                      W K+ L EG+ R+VRR+   +GF   RLIR   G+  L DNL   ++
Sbjct: 168 ITFSGGKGANRWYKVVLREGKKREVRRLWEVLGFKVSRLIRIRFGEIRLPDNLKANQY 225


>UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepID=A9MDW0_BRUC2
          Length = 611

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 17/179 (9%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQA 96
           TR+ L++KP  ++    D  GR T+ E +P +   V + GRLD ++EGLL+LTN+G L  
Sbjct: 163 TRLWLYHKPAGLVTTNRDPEGRPTVFEALPPEMPRVLSVGRLDINTEGLLLLTNDGGLSR 222

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
            L  P     + Y V+  G  TQ  L+ L+NG+ ++        AEL             
Sbjct: 223 VLELPSTGWLRRYRVRAHGKVTQQQLDELKNGIAVDGVFYGSVEAEL------------- 269

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
             ER      W+ I L EG+NR+V+ +   +G    RLIR + G + L +L  G  RE+
Sbjct: 270 --ERVQGANVWISIGLREGKNREVKNILGALGLTVGRLIRVSFGPFQLGDLEEGAVREI 326


>UniRef50_A0LG30 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LG30_SYNFM
          Length = 250

 Score = 84.7 bits (208), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 67/176 (38%), Positives = 91/176 (51%), Gaps = 17/176 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L  KP   +    D  GRKT+ +F+P  G  ++  GRLD D+EGLL+LTN+G L  RL 
Sbjct: 67  LLLFKPRCCVTTARDPQGRKTVFDFVPDAGARLFPVGRLDFDAEGLLLLTNDGLLANRLQ 126

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y V   G PT  AL+ LR GV L +G T PA   ++       PR      
Sbjct: 127 HPRYGVTKTYEVAAMGHPTPAALDRLRTGVMLEEGMTAPAEVTVIGSS----PR------ 176

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
                ++ L+I L++G NRQ++RM   VG P L + R A G   L +L  G  R +
Sbjct: 177 -----STRLRIVLHQGWNRQIKRMGEAVGHPVLSIKRVAFGPLKLGSLKPGGSRHL 227


>UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=C4ZJR2_THASP
          Length = 379

 Score = 84.7 bits (208), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVY-AAGRLDRDSEG 84
           R T+R P     RV++++KP   +    D  GR T+ E +P+  +G + A GRLD ++ G
Sbjct: 172 RFTQRSP-----RVLIYHKPEGEIVSRDDPEGRPTVFERLPILRKGRWLAVGRLDFNTSG 226

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ TN+G L  +L  P     + Y V++ G  T++ +++L +G+ L DG   PA   L+
Sbjct: 227 LLLFTNDGDLANKLMHPRYELEREYAVRILGELTEEQVKSLTDGIQLEDG---PAKFNLL 283

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
            +            E       W ++T+ EGRNR+VRRM   VG    RL+R   G   L
Sbjct: 284 RD------------EGGEGANHWYRVTISEGRNREVRRMFEAVGLTVSRLMRVRYGSVEL 331

Query: 205 -DNLANGEWREVTD 217
              L  G W E+ +
Sbjct: 332 PARLKRGMWMEMPE 345


>UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter heparinus DSM 2366
           RepID=C6Y027_PEDHD
          Length = 472

 Score = 84.7 bits (208), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 53/175 (30%), Positives = 88/175 (50%), Gaps = 19/175 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP D +    D   R+T+ + +     + +Y  GRLDR++ GLL++TN+G L  +L
Sbjct: 299 VLLNKPKDYITTTDDPQERRTVMQLVEKASRERIYPVGRLDRNTTGLLLMTNDGDLADKL 358

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           + P     KIY+V++    +Q  L  ++ G+ L DG   P     V   +         R
Sbjct: 359 SHPKNGITKIYHVELSRSLSQGDLNKIQFGLELEDGIIKPDSVSYVTGGSK--------R 410

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           E        + I ++ G+NR VRR+  H+G+  ++L R   G+ +  +L  G WR
Sbjct: 411 E--------VGIQIHSGKNRIVRRIFEHLGYDVVKLDRVVYGNLTKKDLPRGRWR 457


>UniRef50_C2KPR0 Pseudouridine synthase n=3 Tax=Mobiluncus RepID=C2KPR0_9ACTO
          Length = 278

 Score = 84.7 bits (208), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 62/176 (35%), Positives = 86/176 (48%), Gaps = 19/176 (10%)

Query: 44  FNKPYDVLPQFTDEAGRKTLKEF---IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           FNKP   +     E  R  L ++   +P Q V+  GRLD  + GL++LTNNG L  RL  
Sbjct: 106 FNKPVGTVSTMQPEDDRPCLGDWATKLP-QRVFHVGRLDVATAGLILLTNNGDLANRLVH 164

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y   V+G       + LR GV L DG T     +LV+           +R  
Sbjct: 165 PRYEVPKTYVAMVQGQVKPGLGKVLRRGVELEDGVTKVDTFKLVE-----------VRRG 213

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            SI    +++TL+ G+NR VRR+ + VG P   L R A+G   L +L  G +R +T
Sbjct: 214 SSI----VQLTLHSGKNRVVRRLLSEVGHPVSALTRTAIGTLRLGDLKEGHFRLLT 265


>UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium RepID=C8NNL7_COREF
          Length = 329

 Score = 84.3 bits (207), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 54/185 (29%), Positives = 81/185 (43%), Gaps = 20/185 (10%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRDSEGLLVLTN 90
           N+     + NKP  +    +D+ GR  + + +       Q ++  GRLD D+EGLL+LTN
Sbjct: 146 NEDLEYFVLNKPRGMHSTMSDDLGRPCVGDLVSEKTASGQRLFHVGRLDADTEGLLLLTN 205

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L  RL  P     K Y   V G    + +  LR G+ L DGP      +++D     
Sbjct: 206 DGELANRLMHPKYEVRKTYLATVRGEAGPNLVTTLRKGIELEDGPAKADYVQIIDTFQG- 264

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                          S +++ ++EGR   VRRM    GFP  RL+R  +    L     G
Sbjct: 265 --------------KSLIRLEIHEGRKHIVRRMLDEAGFPVERLVRTKLHTVQLGEQKPG 310

Query: 211 EWREV 215
             R +
Sbjct: 311 SLRAL 315


>UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3JBA6_9PORP
          Length = 459

 Score = 84.3 bits (207), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 52/179 (29%), Positives = 86/179 (48%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP + +   +D   R T  + +     + +Y  GRLDR++ GLL+LTN+G L A+L
Sbjct: 285 VLLNKPRNCVTTSSDPEKRLTAIDLVRNACNERIYPVGRLDRNTTGLLLLTNDGDLAAKL 344

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     KIY V ++   + + ++ + +G+ L DG         VDE            
Sbjct: 345 MHPKYEKKKIYQVTLDKPVSVEHMQQIASGIELEDGEIHADAISYVDENNL--------- 395

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                  + + I ++ GRNR VRR+  H+G+   +L R      +  +L  G WR +T+
Sbjct: 396 -------AIVGIEIHSGRNRIVRRIFKHLGYRVYKLDRVYFAGLTKKDLPRGRWRYLTE 447


>UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZ55_9FIRM
          Length = 250

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 53/190 (27%), Positives = 97/190 (51%), Gaps = 15/190 (7%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGAL 94
           + T  I  NKP   +   +DE GR+T+ + +    + ++  GRLD+DSEGL++LTN+G L
Sbjct: 58  KKTVYIAMNKPCGYVCTVSDELGRRTVYDLLTDIDERLFTIGRLDKDSEGLILLTNDGDL 117

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN-------DGPTLPAGAELVDEP 147
             +L  P ++  K Y V V G+P  + ++ L  G+T++           + +  +   +P
Sbjct: 118 AQKLLSPKRKIEKNYEVVVRGVPGANDIKKLSGGITIDVEISQTKQNKPVKSIVKYHTKP 177

Query: 148 AWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNL 207
           A ++       + K      L + + EG+ RQ+R+M   +G   ++L R       L +L
Sbjct: 178 AKIFEIGQKQGDMK------LSMIIKEGKKRQIRKMFDVIGHEVIKLKRVKFAGIELGDL 231

Query: 208 ANGEWREVTD 217
             GE+R +++
Sbjct: 232 RPGEFRHLSE 241


>UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q15Q67_PSEA6
          Length = 241

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 54/184 (29%), Positives = 87/184 (47%), Gaps = 28/184 (15%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQ------GVYAAGRLDRDSEGLLVLTNNGAL 94
           +++ NKP   +    +  G + + + +P +       + + GRLD+D+ GL+++T++  L
Sbjct: 73  LVMLNKPLGYVCSHDNNEGMR-IYDLLPERWEFRNPKIVSVGRLDKDTSGLILVTDDTKL 131

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWP 152
             +LT P     K+Y V V+     D +++   GV L +G    LPA  E+V E      
Sbjct: 132 VHQLTSPKHHVDKVYQVSVDCPLQSDIIDSFAKGVVLGEGAEQCLPAKIEIVSE------ 185

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                        +   +TL EG+  QVRRM A  G+    L R   G Y L +LA GEW
Sbjct: 186 -------------NVANVTLNEGKYHQVRRMFAACGYHVEALHRSQFGQYRLQDLAQGEW 232

Query: 213 REVT 216
           + V 
Sbjct: 233 QTVA 236


>UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silvestris BL2
           RepID=B8ETE9_METSB
          Length = 676

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 59/182 (32%), Positives = 92/182 (50%), Gaps = 20/182 (10%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-----VYAAGRLDRDSEGLLVLTNNGA 93
           TR+ LF+KP  ++    D  GR T+ +++         + + GRLD ++EGLL+LTN+G 
Sbjct: 84  TRLFLFHKPRGLVTTEHDPEGRPTVFDYVREHSPEAPRLVSIGRLDINTEGLLLLTNDGG 143

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L   L  P     + Y V+ +G   Q  L+ LR GVT+        G +     A L   
Sbjct: 144 LARVLELPATGWARRYRVRAKGSIDQPTLDRLRQGVTVE-------GVDYAQIEATL--- 193

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                +R      WL ++L EG+NR+++R+  H+G    RLIR + G + L +L  G+  
Sbjct: 194 -----DRIQGANCWLTMSLREGKNREIKRVLEHLGLEVNRLIRLSYGPFQLADLEEGKVE 248

Query: 214 EV 215
           EV
Sbjct: 249 EV 250


>UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B1M661_METRJ
          Length = 601

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 61/184 (33%), Positives = 92/184 (50%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           P  + +R+ +F+KP  V+    D  GR+T+ + +P  +  V A GRLD ++EGLL+LTN+
Sbjct: 140 PSRERSRLWIFHKPRGVVTTARDPEGRQTVFDVLPEDLPRVVAVGRLDINTEGLLLLTND 199

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   +  P     + Y V+  G   Q  L+ L  GVT++     P  A L        
Sbjct: 200 GGLAKVIAHPDTGWLRRYRVRAHGDTDQAQLDRLAKGVTIDGMEYGPVEATL-------- 251

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  +R      WL + L EG+NR+V+R+  H+G    RLIR + G + L +L  G 
Sbjct: 252 -------DRVQGDNVWLTLGLREGKNREVKRILEHLGLSVNRLIRLSFGPFQLGDLEVGL 304

Query: 212 WREV 215
             EV
Sbjct: 305 VEEV 308


>UniRef50_D1N1S2 Pseudouridine synthase n=1 Tax=Victivallis vadensis ATCC BAA-548
           RepID=D1N1S2_9BACT
          Length = 241

 Score = 84.0 bits (206), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 65/178 (36%), Positives = 88/178 (49%), Gaps = 22/178 (12%)

Query: 42  ILFNKPYDVLPQFTD-EAGRKT--LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           I+ NKP   +    D  A  K   L    P   +++AGRLD+DSEGL++ +N+G   ARL
Sbjct: 69  IMLNKPRGYVCTNADPHADLKAVDLIRLTPPLRLFSAGRLDKDSEGLILFSNDGDYVARL 128

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K+Y V+V        LE +R GV L  G  L   A                 
Sbjct: 129 THPRHEILKVYQVRVRREFKPAELEQMRRGV-LERGELLKVHA----------------- 170

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
             +    ++L ITL EG+NR++RR+TA +G PT RL R  +G   L  L  G WRE+T
Sbjct: 171 VSRCGDCTYL-ITLNEGKNREIRRLTAALGSPTRRLKRLQIGALRLGGLPVGNWRELT 227


>UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wolfei subsp. wolfei
           str. Goettingen RepID=Q0AX41_SYNWW
          Length = 239

 Score = 84.0 bits (206), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 53/177 (29%), Positives = 84/177 (47%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L +KP   +    D  GR  + + +      V+  GRLD D+EGLL+L+N+G     +T
Sbjct: 62  LLLHKPAGYISSLADPQGRPRVIDLLSAVNTRVFPVGRLDYDTEGLLLLSNDGEFSNLMT 121

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y   V+G+   D +  L  GV L DG T PA   L+               
Sbjct: 122 HPRYLIPKKYEAWVQGLVKPDTIRQLEQGVALEDGITAPARVRLLSSKKG---------- 171

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                 S L++ ++EG+ RQ++RM   VG    +L R A+   +L+ +  G++R +T
Sbjct: 172 -----QSLLELEIHEGKKRQIKRMCLAVGHRVTKLKRTALAFLTLEGVPRGQFRFLT 223


>UniRef50_A5ZYR1 Pseudouridine synthase n=2 Tax=Clostridiales RepID=A5ZYR1_9FIRM
          Length = 315

 Score = 84.0 bits (206), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 63/188 (33%), Positives = 95/188 (50%), Gaps = 24/188 (12%)

Query: 33  KPENQPTR--VILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAGRLDRDSEGLLVL 88
           +P    TR  ++LF KP  ++     +    T+ EF+  PV+ VY  GRLD+DSEGLL+L
Sbjct: 63  RPVKAETRQVLLLFYKPRGIVCSTKKQRQETTVTEFLDYPVR-VYPVGRLDKDSEGLLLL 121

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN G L  R+ + G    K Y V V+   T+  +  + +GV     P L      V  P 
Sbjct: 122 TNQGDLVNRIMRAGNYHEKEYEVTVDKKITETFIRKMSSGV-----PILGT----VTRPC 172

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
            ++         K+   S+  I L +G NRQ+RRM  ++G+    L R  + + +LD L 
Sbjct: 173 TVY---------KTGDKSF-SIILTQGLNRQIRRMCEYLGYHVCTLKRIRIMNLTLDGLK 222

Query: 209 NGEWREVT 216
            GE+RE+ 
Sbjct: 223 CGEYREIC 230


>UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=B9MRL6_ANATD
          Length = 233

 Score = 84.0 bits (206), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 57/196 (29%), Positives = 97/196 (49%), Gaps = 30/196 (15%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLD 79
           +V +FS Q        N+P   +  N+    L  F+       + + +  + ++  GRLD
Sbjct: 53  RVAKFSKQIYIMM---NKPKGYVCSNEELASLTVFS------LISDDLKYRDLHTVGRLD 103

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLP 138
           +D+EGLL++T++G    R+  P KR  K Y V++E    ++ L    NG+ L+DG  TLP
Sbjct: 104 KDAEGLLIITDDGEYTHRVISPKKRIEKEYLVRLEKEVDEEKLNEFENGIILDDGYKTLP 163

Query: 139 AGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYA 198
           A   ++D                   ++ +K+ +YEG+  QV+RM   +G   + L R  
Sbjct: 164 AKYTIID-------------------STTVKLCIYEGKYHQVKRMFEAIGNKVVDLKRLR 204

Query: 199 MGDYSLD-NLANGEWR 213
           +G  +LD +L  GE+R
Sbjct: 205 IGGLNLDQSLKPGEYR 220


>UniRef50_A6DF49 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DF49_9BACT
          Length = 236

 Score = 84.0 bits (206), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 66/213 (30%), Positives = 100/213 (46%), Gaps = 27/213 (12%)

Query: 15  SFRNHQVKRFSSQRST-------RRKPENQPTRVI-LFNKPYDVLPQFTDEAGRKTLKEF 66
           +  NH+V   S+Q          RRKP     ++  L NKP   +    D    K   + 
Sbjct: 28  TINNHRVTELSTQVDVDNDEVRYRRKPLVLEKKLYYLLNKPVGYVCTNDDPFAEKKAIDL 87

Query: 67  IPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL 125
           +P +G +Y  GRLD+ SEGL+VLTN+G L   +T P     K Y V V+G  +Q  L+ L
Sbjct: 88  LPDKGRLYTVGRLDKPSEGLIVLTNDGDLAKIMTHPSFELEKKYRVTVKGRVSQKKLDYL 147

Query: 126 -RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWL-KITLYEGRNRQVRRM 183
            R+G+T            ++D            R +K +P  ++   TL EG+NR++R++
Sbjct: 148 VRDGLTFEG-----VNYRVLDA-----------RIKKQVPGGYMINFTLNEGKNREIRKI 191

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              +     RL RY +   +L  L  G WR +T
Sbjct: 192 CQSLDLQVKRLRRYEIAGIALGKLPPGAWRPMT 224


>UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii DSM 20583
           RepID=C9L6I1_RUMHA
          Length = 271

 Score = 83.2 bits (204), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 63/207 (30%), Positives = 103/207 (49%), Gaps = 24/207 (11%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPENQPTRVIL-FNKPYDVLPQFTDEAGRKTLKEFI--PV 69
           K + +  QV+ F   +   +  + +  +V+L F+KP  +         +K +  +I  P+
Sbjct: 32  KPAVQGMQVEDFQEIKVDGKAIKREEKKVLLVFHKPKGIECTANPNV-KKNVISYINYPI 90

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           + VY AGRLD+DSEGLL+LTN G L  ++ + G    K Y V V+   T++ L+++R GV
Sbjct: 91  R-VYYAGRLDKDSEGLLLLTNQGELVNQIMKAGSYHEKEYLVTVDKPVTEEFLQSMREGV 149

Query: 130 TLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
            +    T     E   E  +                   +ITL +G NRQ+RRM  ++G+
Sbjct: 150 PVLGTITRKCKVEKESEKVF-------------------RITLTQGLNRQIRRMCNYLGY 190

Query: 190 PTLRLIRYAMGDYSLDNLANGEWREVT 216
             ++L R  + +  L NL  G +RE T
Sbjct: 191 EVVKLKRIRIMNIELGNLPIGSYREAT 217


>UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5SLZ5_THET8
          Length = 243

 Score = 83.2 bits (204), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 56/176 (31%), Positives = 84/176 (47%), Gaps = 18/176 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           +L +KP   +   T+      L +  P + +   GRLD+D+EGLL+ T +G L  RLT P
Sbjct: 65  VLLHKPPGFVTSRTEGPSVYALLQGFPTRDLSPVGRLDKDAEGLLLFTTDGLLLHRLTHP 124

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
             +  K Y V +E        EA R G+ L+   TLPA    +++P              
Sbjct: 125 RHKVAKRYLVHLERPVGPKDQEAFREGILLDGKKTLPAELTPLEDP-------------- 170

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
               +W ++ L EGR  Q++RM    G   LRL R A+G   L +L  G+ R +T+
Sbjct: 171 ----TWAEVVLKEGRFHQIKRMFRARGNRVLRLKRLALGPLELGDLPPGKARPLTE 222


>UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EVQ2_DICNV
          Length = 266

 Score = 83.2 bits (204), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 61/183 (33%), Positives = 94/183 (51%), Gaps = 14/183 (7%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAA-GRLDRDSEGLLVLTNNGAL 94
           P  +++++KP   +    D  GR ++ + +P    G + A GRLD ++ GLL+ TN+GAL
Sbjct: 70  PHMILMYHKPAGEICTRKDPEGRVSVFQHLPKISHGRWVAIGRLDLNTSGLLLFTNDGAL 129

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             +L  P     + Y+V+V G  T++ L ALR G+ L+DG  L    E+           
Sbjct: 130 ANQLMHPSAEIEREYWVRVAGEVTEEMLTALRQGIPLDDG--LARFTEICPLKT------ 181

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWR 213
             + E  +    +  +TL EGRNR+VRR+   VG    RL R   G  SL  +L+ G  R
Sbjct: 182 --LHEDDTQFNRYFSVTLKEGRNREVRRLWEAVGCKVSRLKRIRYGTISLPPSLSAGRHR 239

Query: 214 EVT 216
            +T
Sbjct: 240 LLT 242


>UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196BAD7
          Length = 247

 Score = 83.2 bits (204), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 55/175 (31%), Positives = 77/175 (44%), Gaps = 19/175 (10%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           LF KP   +   +DE  R  + ++       VY  GRLD D+ G L +TN+G     +  
Sbjct: 65  LFYKPEKCVCTMSDEHDRTCVADYFADSNERVYPVGRLDYDTTGALFMTNDGEFANLIMH 124

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV--DEPAWLWPRNPPIR 158
           P     K+Y V V+G+ T+     L  G+ L    TLP    +   DE            
Sbjct: 125 PSSHLEKVYEVSVKGLLTKAEKNQLEKGIYLEGVKTLPCEIAITGNDEEHG--------- 175

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                 T+ L I L EG+NRQ+++M   VG P  RL R  +G   L  L  G +R
Sbjct: 176 ------TTMLLIRLVEGKNRQIKKMFEEVGHPVKRLRRIMIGPIDLKGLTPGTYR 224


>UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1DTU8_SULAA
          Length = 247

 Score = 83.2 bits (204), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 50/167 (29%), Positives = 83/167 (49%), Gaps = 21/167 (12%)

Query: 56  DEAGRKTLKEF-----IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYY 110
           D  GRKTL +F     IP + ++  GRLD +SEGLL+LTN+G    ++  P     K+Y 
Sbjct: 80  DRFGRKTLTDFLNELKIPYK-LFPVGRLDYNSEGLLILTNDGEFANKVAHPRNEIKKVYK 138

Query: 111 VQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKI 170
           V+V G  +Q+ L+ +  G  L DG   P   +++               ++    +WL +
Sbjct: 139 VKVAGEVSQETLKKMEEGTILEDGFFKPDKIKML---------------KREEDGTWLLV 183

Query: 171 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            ++ G+ R +RR     G    RLIR  +G   + NL   ++R +++
Sbjct: 184 EIHSGKKRIIRRFMDSFGHRVKRLIRVKIGSIDIGNLKPFDYRYLSE 230


>UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacteria
           RepID=Q13BM8_RHOPS
          Length = 795

 Score = 82.8 bits (203), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 63/186 (33%), Positives = 95/186 (51%), Gaps = 21/186 (11%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           PE + TR+ L++KP  ++    D  GR T+ + +P  +  + + GRLD ++EGLL+LTN+
Sbjct: 530 PERERTRLFLYHKPRGLMTTHADPEGRPTVFDNLPEDLPRLISIGRLDFNTEGLLLLTND 589

Query: 92  GALQARLTQPGKRTG--KIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           G L   L  P   TG  + Y V+  G  TQ  L+ L +GV ++     P  A+L      
Sbjct: 590 GGLARALELP--ETGWLRRYRVRAHGEVTQAQLDQLASGVEVDGVKYGPIEAKL------ 641

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                    ER      WL   + EG+NR+VR + AH+G    RLIR + G + L  +  
Sbjct: 642 ---------ERDQGANVWLVFAIREGKNREVRNVLAHLGLEVNRLIRVSYGPFQLLEIEE 692

Query: 210 GEWREV 215
           G+  EV
Sbjct: 693 GQVEEV 698


>UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U325_9PROT
          Length = 387

 Score = 82.8 bits (203), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 59/184 (32%), Positives = 89/184 (48%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           PE +P R+  ++KP  ++    D  GR T+ + +P  +  V   GRLD DSEGLL+LTN+
Sbjct: 63  PEIEPPRLWRYHKPDGLVTSNRDPEGRSTVFDRLPKDLPRVVTVGRLDIDSEGLLLLTND 122

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   L  P     + Y V+V G   +  L+ L+ GV +      P    +        
Sbjct: 123 GGLARYLELPSTGWVRRYRVRVFGPLDEAKLDNLKKGVRIEGVEYGPIEVTI-------- 174

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  ++ +   SWL + L EG+NR++RR+  HVG    RLIR   G + L  +  G 
Sbjct: 175 -------DKATRTNSWLTVALREGKNREIRRVMEHVGLTVSRLIRTTYGPFQLGEVPPGG 227

Query: 212 WREV 215
             E+
Sbjct: 228 VEEI 231


>UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales RepID=C6J9Y4_9FIRM
          Length = 323

 Score = 82.8 bits (203), Expect = 8e-15,   Method: Compositional matrix adjust.
 Identities = 53/184 (28%), Positives = 94/184 (51%), Gaps = 22/184 (11%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAGRLDRDSEGLLVLTNNG 92
           +N+   ++LFNKP  ++     +    T+ +++  P++ VY  GRLD++S+GLL+LTN G
Sbjct: 68  KNEKKVLLLFNKPRGIVCSTKQQFDETTVTDYLDYPLR-VYPVGRLDKESQGLLLLTNEG 126

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L  ++ + G    K Y+V V     ++ +  +  GV + D  T P       E ++   
Sbjct: 127 DLVNKIMRAGNYHEKEYFVTVNKPVDREFVRRMSKGVPVLDTVTRPCRVVQTGECSF--- 183

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                           +I L +G NRQ+RRM  ++G+   +L R  + + +LD +  GE+
Sbjct: 184 ----------------RIILTQGLNRQIRRMCRYLGYEVQKLKRIRIMNLTLDGIREGEY 227

Query: 213 REVT 216
           RE+T
Sbjct: 228 REIT 231


>UniRef50_B2UKZ1 Pseudouridine synthase n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UKZ1_AKKM8
          Length = 230

 Score = 82.4 bits (202), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 60/169 (35%), Positives = 85/169 (50%), Gaps = 26/169 (15%)

Query: 56  DEAGRKTLKEFIPVQ------GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIY 109
           D+     + + +P Q       V + GRLD+++ GLL+LT++G    R+T P     K+Y
Sbjct: 74  DDGEGNLIYDLLPFQWRHRNPAVSSVGRLDKETSGLLLLTDDGKFIHRMTSPRHHVAKVY 133

Query: 110 -YVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWL 168
             V  E IPT+ A+E   +G    +G T P        PA L  R P    R+++     
Sbjct: 134 EAVTEEDIPTE-AVELFASGTLTLNGETRPCA------PALLEIREP----RRAL----- 177

Query: 169 KITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD--NLANGEWREV 215
            +TL EG+  QVRRM A VG P L L R ++G   LD  NL  GEW  +
Sbjct: 178 -LTLTEGKYHQVRRMLAAVGAPVLSLCRVSIGSLHLDSLNLKPGEWAPI 225


>UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum variabile DSM 15176
           RepID=D1PIW4_9FIRM
          Length = 237

 Score = 82.4 bits (202), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 26/182 (14%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI----PVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           I+ NKP  V+    D+    T+ + +    P + ++ AGRLD+ S G ++LT++GAL   
Sbjct: 65  IMLNKPEGVVSASRDKR-DTTVVDLVAADFPRRALFPAGRLDKTSTGFVLLTDDGALAHD 123

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEA-LRNGVTLNDGPTL-PAGAELVDEPAWLWPRNP 155
           L  P     K Y V ++  P  DA+ A    GVTL DG T+ PA AE   E       +P
Sbjct: 124 LLSPAHHVDKQYLVTLD-TPLTDAMRAGFAAGVTLADGETMAPAEAEPAGE-------DP 175

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWRE 214
            +          +K+TL++G   Q++RM    G     L RYA+G  +LD  LA G+WRE
Sbjct: 176 CV----------VKVTLHQGVYHQIKRMFGVYGAGVNALHRYAIGGVALDAALAPGQWRE 225

Query: 215 VT 216
           +T
Sbjct: 226 LT 227


>UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organisms
           RepID=A0NV51_9RHOB
          Length = 520

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 59/184 (32%), Positives = 95/184 (51%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           P  + TR+ L++KP  ++    D  GR T+ E +P  +  V   GRLD ++EGLL+LTN+
Sbjct: 157 PMRERTRLWLYHKPRGLVTTNKDPEGRPTVFERLPDDLPRVLTVGRLDINTEGLLLLTND 216

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   L  P     + Y V+  G  TQ  L+ L++G+ + +G    A    +D      
Sbjct: 217 GGLARVLELPATGWLRRYRVRAFGKVTQPDLDTLKDGIAI-EGVLYGAIEATLD------ 269

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                   ++     W+ + L EG+NR+V+R+  H+G    RLIR + G + L +L  G+
Sbjct: 270 --------KEQGNNVWMTVGLREGKNREVKRVLEHLGLAVNRLIRLSYGPFQLMDLPEGD 321

Query: 212 WREV 215
            RE+
Sbjct: 322 VREI 325


>UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (class)
           RepID=D2B9T7_STRRD
          Length = 621

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 57/177 (32%), Positives = 83/177 (46%), Gaps = 17/177 (9%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +  NKP  V+   +D  GR +L +F+    + ++  GRLD ++EGL++LTN+G L  RLT
Sbjct: 447 LAINKPIGVVSTMSDPDGRPSLADFVADRTERLFHVGRLDTETEGLILLTNDGELANRLT 506

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     K Y+ +V G   +D    L+ G+ L DG        LV E             
Sbjct: 507 HPSYGVQKKYWAKVPGRIERDLGRRLKKGIELEDGIAKADSFTLVQEHGQ---------- 556

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                 + +++ L+EGR   VRRM   VG P + L R   G   L  L  G  R +T
Sbjct: 557 -----QALVEVVLHEGRKHIVRRMLEEVGHPVIDLARIEFGPVKLGRLKPGTVRALT 608


>UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovibrio salexigens DSM
           2638 RepID=C6BUF1_DESAD
          Length = 251

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 58/181 (32%), Positives = 87/181 (48%), Gaps = 21/181 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           IL +K  + +    D  GRKT+ + +P     + V+  GRLD  SEG+L+LT +G L  R
Sbjct: 72  ILLHKTIETVTTAKDPQGRKTVLDLLPPDVINRRVFPVGRLDFYSEGMLLLTTDGELCNR 131

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL--PAGAELVDEPAWLWPRNP 155
           +T P     KIY+V + G  ++  L  ++NG+ L D   L  P   + + E         
Sbjct: 132 MTHPKWHLPKIYHVTIRGKLSEKELSVMQNGMYLEDKGELLAPVKIKAISEVG------- 184

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
                    T+  ++ L +G NRQ+RRM        LRL R   G   L  L  G+WRE+
Sbjct: 185 --------ETTKYEMELRQGINRQIRRMFGEFDKTILRLKRVRQGRIELGALKPGKWREL 236

Query: 216 T 216
           +
Sbjct: 237 S 237


>UniRef50_A8I6C3 Pseudouridine synthase n=6 Tax=Alphaproteobacteria
           RepID=A8I6C3_AZOC5
          Length = 717

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 65/186 (34%), Positives = 93/186 (50%), Gaps = 21/186 (11%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           PE + TR+ L++KP  V+    D  GR TL E +P  +  + + GRLD +SEGLL+LTN+
Sbjct: 84  PERERTRLFLYHKPIGVVTTNRDPEGRTTLFELLPGHLPRLVSVGRLDINSEGLLLLTND 143

Query: 92  GALQARLTQPGKRTG--KIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           G L   L  P   TG  + Y V+ +G   Q  L+AL  G+ +        G E     A 
Sbjct: 144 GGLARVLELP--ETGWLRRYRVRAKGTVDQAQLDALIKGIVVE-------GVEYGPIEAV 194

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
           L        +R      W+ + L EG+NR+VR +   +G    RLIR + G + L  +A 
Sbjct: 195 L--------DRVQGANVWITVALREGKNREVRNVLGALGLQVNRLIRISYGPFQLGEIAE 246

Query: 210 GEWREV 215
           G   EV
Sbjct: 247 GGVEEV 252


>UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B n=117 Tax=Bacteria
           RepID=RLUB_ECO57
          Length = 290

 Score = 82.0 bits (201), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 65/193 (33%), Positives = 88/193 (45%), Gaps = 29/193 (15%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGV--YAAGRLDRDSEGLLVL 88
           R+   Q  RV+ + KP   L    D  GR T+ + +P ++G    A GRLD ++ GLL+ 
Sbjct: 60  RESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLF 119

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-----PAGAEL 143
           T +G L  RL  P +   + Y V+V G      L  L  GV L DGP        +G E 
Sbjct: 120 TTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEG 179

Query: 144 VDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYS 203
           +++                    W  +TL EGRNR+VRR+   VG    RLIR   GD  
Sbjct: 180 INQ--------------------WYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIP 219

Query: 204 L-DNLANGEWREV 215
           L   L  G W E+
Sbjct: 220 LPKGLPRGGWTEL 232


>UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UUP0_RHOBA
          Length = 395

 Score = 82.0 bits (201), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 51/175 (29%), Positives = 89/175 (50%), Gaps = 16/175 (9%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           + NKP  ++    D  GR  + + +P  + V+  GRLD  SEGL++LTN+G L  +L  P
Sbjct: 88  VVNKPVGIVTTNRDPRGRPRVIDLVPPTERVFPVGRLDISSEGLILLTNDGDLAQKLAHP 147

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
                K+Y V V G    + ++ +R G+ + +G     GA+++               + 
Sbjct: 148 KFGIQKVYRVVVAGEVRGETMKKMREGIYIAEGLVQVDGAKII---------------KA 192

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
               + ++I L EG+NR++RR+ A  G    +L R A+G   L ++  G +R++T
Sbjct: 193 RTKATEMEIRLKEGKNREIRRILARFGHKVQQLRRVAIGPLKLGDVPRGAYRKLT 247


>UniRef50_B7G1P9 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G1P9_PHATR
          Length = 331

 Score = 82.0 bits (201), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 18/181 (9%)

Query: 38  PTRVILFNKPYD---VLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGAL 94
           P  ++  N PYD   +L +       K  K  + ++ V   GRLD ++EGL+++TN+G  
Sbjct: 127 PGEIVADNDPYDRPSLLQRLIRGGVGKVGKTRLHLKSV---GRLDMNTEGLILVTNDGKY 183

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              +  P  +  + Y V+V G+ T   L  +R GVT+ +G   P        P  + P +
Sbjct: 184 AREMELPSNKLHRTYRVRVHGLLTDHKLARIRKGVTV-EGIRYP--------PMRIIPES 234

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
              R+ +S    WLK+T  EG+NRQ+R +  ++G    RLIR + GDY L  +  G   E
Sbjct: 235 --TRQSQST-NKWLKVTCTEGKNRQIRNVFKYLGLTVTRLIRISYGDYRLQTIPPGMAIE 291

Query: 215 V 215
           V
Sbjct: 292 V 292


>UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=A6GNL7_9BURK
          Length = 458

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 58/182 (31%), Positives = 88/182 (48%), Gaps = 28/182 (15%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVY-AAGRLDRDSEGLLV 87
           +RK +++P RV++++KP   +    D  GR T+ + +P    G + A GRLD ++EGLL+
Sbjct: 122 QRKNKSKPPRVLIYHKPAGEIVSMDDPQGRTTVFQKLPKISNGKWIAVGRLDFNTEGLLL 181

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-----PAGAE 142
            T++G L  RL  P     + Y V++ G  +++  + L  G+ L DGP        AG E
Sbjct: 182 FTSSGELANRLMHPRYEVQREYAVRILGELSEEQRQQLLTGIQLEDGPAKFLYVDAAGGE 241

Query: 143 LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
             +                     W K+ L EGRNR+VRRM         RLIR   GD 
Sbjct: 242 GANR--------------------WYKVGLKEGRNREVRRMFEACNLTVSRLIRTRFGDI 281

Query: 203 SL 204
            +
Sbjct: 282 MM 283


>UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=A1UU09_BARBK
          Length = 499

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 58/179 (32%), Positives = 91/179 (50%), Gaps = 17/179 (9%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQA 96
           TR+ L++KP  ++    D  GR T+ + +P +   V + GRLD ++EGLL+LTN+G L  
Sbjct: 104 TRLWLYHKPSGLVTTNRDPEGRPTVFDNLPKEMPRVVSVGRLDINTEGLLLLTNDGGLAR 163

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
            L  P     + Y V+  G   Q  L+ L+NG+ + DG    +    +D           
Sbjct: 164 VLELPLTGWVRKYRVRAHGKIKQSELDKLKNGIAI-DGIFYGSIDASID----------- 211

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            RE+ S    WL + L EG+NR+++     +G    RLIR + G + L +L  G  RE+
Sbjct: 212 -REQGS--NVWLSVALREGKNREIKNFLGALGLSVNRLIRVSYGPFQLSDLEEGAVREL 267


>UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZX4_ACIFD
          Length = 254

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 62/160 (38%), Positives = 80/160 (50%), Gaps = 22/160 (13%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           L NKP  V+    D  GR T++  +     VY  GRLD DSEGLL+LTN+G L  +LT P
Sbjct: 69  LLNKPRGVVSSVVDPEGRPTVRSLVATTSRVYPVGRLDVDSEGLLILTNDGPLTYQLTHP 128

Query: 102 GKRTGKIYYVQVE-GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
                K Y V V+  +P +   E LR GV + DG  L A +        + PR       
Sbjct: 129 RFHVPKEYLVWVDRPVPRRLGRE-LREGVEV-DGELLRASSV-----GTVGPR------- 174

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
                  ++I L EGRNRQ+RRM   VG    RL+R  +G
Sbjct: 175 ------LVRIVLTEGRNRQIRRMVGAVGLSVERLVRVRIG 208


>UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K31
           RepID=B0T1Z8_CAUSK
          Length = 501

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 63/186 (33%), Positives = 96/186 (51%), Gaps = 18/186 (9%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           E + TRV  ++KP  ++    D   R T+ + +P  +  + + GRLD +SEGLL+LTN+G
Sbjct: 79  EPEATRVFRYHKPSGLMTTHNDPKQRPTVFQALPRDLPRLISVGRLDLNSEGLLLLTNDG 138

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND---GPTLPAGAELVDEPAW 149
           AL   L  P     + Y  +  G  TQ  L+ L++G T+     GP + A  +   E A 
Sbjct: 139 ALSRALEMPQNAWVRRYRARAFGDTTQAKLDKLKDGCTVEGVRYGP-IEARLDKAQEKAG 197

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                      K+I   W+ +TL EG+NR+VRR+   +G    RLIR + G ++L  L  
Sbjct: 198 GG---------KNI---WITLTLSEGKNREVRRVLESIGLKVNRLIRLSYGPFALGTLLP 245

Query: 210 GEWREV 215
           G+  EV
Sbjct: 246 GQVEEV 251


>UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacteria
           RepID=B7L142_METC4
          Length = 674

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 61/184 (33%), Positives = 92/184 (50%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNN 91
           P  + TR+ L +KP  V+    D  GR T+ + +P +   V A GRLD ++EGLL+LTN+
Sbjct: 76  PARERTRLWLLHKPRGVVTTARDPEGRPTVFDGLPEELPRVVAIGRLDINTEGLLLLTND 135

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   +  P     + Y V+  G  TQ  L+ L+ G+T++     P  A L        
Sbjct: 136 GGLAKVIAHPDTGWLRRYRVRAFGDVTQPDLDKLKKGLTVDGMEYGPIEATL-------- 187

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  +R      WL + L EG+NR+V+R+  H+G    RLIR + G + L +L  G 
Sbjct: 188 -------DRAQGDNVWLTLGLREGKNREVKRILEHLGLSVNRLIRLSFGPFQLGDLEVGL 240

Query: 212 WREV 215
             E+
Sbjct: 241 VEEI 244


>UniRef50_C9RMB6 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RMB6_FIBSS
          Length = 286

 Score = 81.3 bits (199), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 65/203 (32%), Positives = 89/203 (43%), Gaps = 37/203 (18%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFI-----------PVQGVYAAGRLDRDSEGLLVLTN 90
            + NKP   +   +DE GR T+ +             PV  +   GRLD  SEGLL+ TN
Sbjct: 89  FMMNKPRGYVTTASDEKGRATVMDLFREQYAKMFPGKPVPHISPVGRLDAASEGLLLFTN 148

Query: 91  N----GAL-----QARLTQPGKRT---------GKIYYVQVEGIPTQDALEALRNGVTLN 132
           +     AL     + R T+  K            KIY VQV G PT + L  +  G   N
Sbjct: 149 DTQWADALLKTKDERRKTRDDKCVERESRGPIHTKIYRVQVNGHPTAEELSQMEAG--FN 206

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
             P       +  EP                   WL+ITL EG+NR++RRM A +G+  L
Sbjct: 207 VPP------RVFGEPEEFMHAVSAKLYSAGEKNCWLEITLDEGKNREIRRMLAKLGYEVL 260

Query: 193 RLIRYAMGDYSLDNLANGEWREV 215
           RL+R    +Y L +L  GE R++
Sbjct: 261 RLVRIKFCNYELGDLKQGEIRKI 283


>UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus Y51MC23
           RepID=B7A9J5_THEAQ
          Length = 245

 Score = 81.3 bits (199), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 56/175 (32%), Positives = 84/175 (48%), Gaps = 18/175 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQP 101
           +L +KP   +    +      L E  P + +   GRLD+D+EGLL+ T +G L  RLT P
Sbjct: 74  LLLHKPAGYVTSRKEGPSVYALLEGFPTRDLSPVGRLDKDTEGLLLFTTDGELLHRLTHP 133

Query: 102 GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERK 161
             +  K Y V +    T   + A + G+ L+   TLPA   L ++P              
Sbjct: 134 RHKVEKRYLVHLLHPATAADVRAFQEGILLSGEKTLPARLHLGEDP-------------- 179

Query: 162 SIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
               +W+++TL EGR  QV+RM    G   L L R A+G  +L++L  G  R +T
Sbjct: 180 ----TWVELTLLEGRFHQVKRMFQARGNQVLYLKRLALGPLTLEDLPLGAARPLT 230


>UniRef50_C0BLA3 Pseudouridine synthase n=1 Tax=Flavobacteria bacterium MS024-3C
           RepID=C0BLA3_9BACT
          Length = 334

 Score = 81.3 bits (199), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           IL NKP D     TD +  K+    +       +   GRLD+ + GLL+ TN+G LQ +L
Sbjct: 162 ILLNKPKDFDSSATDASQPKSALGLVANATKSKIKPVGRLDKSASGLLLFTNDGELQTKL 221

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T+P     KIY+  +      D LE +R G+ L DGP                 R   I 
Sbjct: 222 TKPKNGFRKIYHATLSKSLKADDLEKVRKGIVLEDGPV----------------RVHEIS 265

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
             +  P + + I +   +N  ++R+  H+G+  ++L R      +  +L  G+WR +T+
Sbjct: 266 NIEGSPATEVGIEILSAKNNIIKRLFDHLGYELIKLDRVVYAGLTKKDLPRGQWRTLTE 324


>UniRef50_C6XHY6 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XHY6_LIBAP
          Length = 354

 Score = 80.9 bits (198), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 54/180 (30%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           TR+ L++KP  ++   +D  GR T+ + +P     V + GRLD ++EGLL+LTN+G L  
Sbjct: 73  TRLWLYHKPIGLVTTHSDPDGRSTVFDNLPSIFSRVISVGRLDINTEGLLLLTNDGGLAR 132

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
            L  P  +  ++Y V+  G   QD L  L+ G+ +        G    D    L      
Sbjct: 133 VLELPSTQWLRVYRVRFHGQVDQDKLNLLKKGIVIQ-------GICYGDMQVTL------ 179

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
             + +    +W+ + L EG+NR+++++     +   RLIR + G + L  L  G  REV+
Sbjct: 180 --DTQKGSNAWVTVGLREGKNREIKKVFEFFNWKVNRLIRISYGPFQLGTLLAGSTREVS 237


>UniRef50_C5EVC9 Pseudouridine synthase n=6 Tax=Clostridiales RepID=C5EVC9_9FIRM
          Length = 294

 Score = 80.9 bits (198), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 58/185 (31%), Positives = 90/185 (48%), Gaps = 21/185 (11%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTN 90
           RKP  +P  +++ NKP  ++   +D+     + E++   + +Y  GRLD+DSEGLL++TN
Sbjct: 95  RKP--KPV-LLVVNKPRGIVCTTSDKDRAMNIVEYLDYPERIYPVGRLDKDSEGLLLMTN 151

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
            G L  ++ + G    K Y V V+   T DA++ +  G+ L +        E V  P  +
Sbjct: 152 QGDLVNKIMRSGNAHEKEYIVTVDRPLTDDAMDRMAKGIYLRE-------LETVTRPCKV 204

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                     K +      I L +G NRQ+RRM    G    RL+R  + +  LD L  G
Sbjct: 205 ----------KRVDGKTFSIILTQGLNRQIRRMCEACGCHVERLVRVRIMNIRLDGLETG 254

Query: 211 EWREV 215
             REV
Sbjct: 255 ASREV 259


>UniRef50_A6BG46 Putative uncharacterized protein n=2 Tax=Clostridiales
           RepID=A6BG46_9FIRM
          Length = 216

 Score = 80.9 bits (198), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 13/186 (6%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +F+KP+  +    D+     +  F  +Q   +   GRLDR++ GLL++T++G    +LT 
Sbjct: 27  MFHKPFGCVTARRDDRYPTVMDYFEELQNDRLSPVGRLDRETTGLLLITDDGIFNQKLTH 86

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA-------GAELVDEPAWLWP- 152
           P     K Y   + G  T + +  L  GV L    TL A       G  ++ +     P 
Sbjct: 87  PSYHKEKTYEFTLLGDLTPELVHKLETGVILKGADTLTAPAKITVTGHAVMSDILSTLPE 146

Query: 153 --RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LAN 209
             +    + R   P ++  IT+ EG+ RQ+RRM   V    + L R ++GD  LD  L  
Sbjct: 147 EIQKDIHKNRPDHPITYGIITISEGKKRQIRRMMKSVHCCVIELKRISIGDIVLDKALCP 206

Query: 210 GEWREV 215
           GEW+E+
Sbjct: 207 GEWKEI 212


>UniRef50_B5YMC9 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YMC9_THAPS
          Length = 365

 Score = 80.9 bits (198), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 21/186 (11%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-------VYAAGRLDRDSEGLLVLT 89
           + TRV L NK    L    D  GR ++ + +   G       +   GRLD  +EGL++ +
Sbjct: 142 KTTRVWLANKLKGELITEDDPDGRPSMLQRLKANGTKHLPTHLKPVGRLDMMTEGLMIFS 201

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           N+G     L  P     + Y V+V G  T   L A+R GVT+       A  E+V     
Sbjct: 202 NDGQYARNLELPSNHLWRTYRVRVHGRLTLGKLTAMRKGVTVRG-----ASGEVVQSTG- 255

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                   ++      +WL+IT  EG+NRQ+RR+   +G    RLIR + GDY L+++  
Sbjct: 256 --------KDVNGSTNTWLQITCTEGKNRQLRRILGSMGLDVTRLIRISYGDYDLNSIPP 307

Query: 210 GEWREV 215
           G   EV
Sbjct: 308 GLAIEV 313


>UniRef50_Q605S3 Pseudouridine synthase n=1 Tax=Methylococcus capsulatus
           RepID=Q605S3_METCA
          Length = 231

 Score = 80.9 bits (198), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 58/170 (34%), Positives = 80/170 (47%), Gaps = 20/170 (11%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV---YAAGRLDRDSEGLLVLTNNGALQ 95
           TRV+L++KP   L    D  GR  +   +P   +    A GRLD +++GL++LTNNG L 
Sbjct: 17  TRVLLYHKPVGELVSRRDPEGRPLIFSRLPRLELGRWVAVGRLDVNTQGLILLTNNGELA 76

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT-LPAGAELVDEPAWLWPRN 154
            RL  P     + Y V++ G  ++  +E L +GV L DGP    + AE   E A      
Sbjct: 77  HRLMHPSHAVEREYAVRILGTVSEAVIERLLDGVQLEDGPARFESVAEAGGEGA------ 130

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                       W  + + EGRNR VRR+         RLIR   GD  L
Sbjct: 131 ----------NRWFHVVVREGRNRLVRRLWESQNLVVSRLIRVRYGDIVL 170


>UniRef50_Q21JF0 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q21JF0_SACD2
          Length = 242

 Score = 80.5 bits (197), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 54/151 (35%), Positives = 76/151 (50%), Gaps = 22/151 (14%)

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           Q +  AGRLD D+ GL++LT+NG    R+T P K   K Y V++E      A++ L  GV
Sbjct: 104 QSLQIAGRLDVDTTGLVLLTDNGEWNHRVTSPNKACFKRYRVKLEKPLDDAAIKLLSEGV 163

Query: 130 TLN--DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
            L+     TLPA  EL+     L                   +++ EGR  QV+RM   V
Sbjct: 164 MLHGEKAATLPATVELISNTEVL-------------------LSIQEGRFHQVKRMFVKV 204

Query: 188 GFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           G   ++L R A+G   LD NL  G+WR +T+
Sbjct: 205 GTCVVKLHREAIGAIELDTNLKPGQWRHLTN 235


>UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia JCVIHMP010
           RepID=D1Y0J0_9BACT
          Length = 555

 Score = 80.5 bits (197), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 51/179 (28%), Positives = 89/179 (49%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +L NKP D +    D   RKT+ + +     + +Y  GRLDR++ G+L+ TN+G L ++L
Sbjct: 381 VLLNKPKDYVTTSDDPQQRKTVMDLVKDACPERIYPVGRLDRNTTGVLLFTNDGDLASKL 440

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K+Y+V ++   T + L+ + +G+ L DG       E           NP   
Sbjct: 441 THPKFLKKKVYHVFLDKPITANELQKISDGIELEDGEIKADAIEYA---------NPE-- 489

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                  + + I ++ G+NR VRR+   +G+  ++L R      +  N+  G+WR +T+
Sbjct: 490 -----DQAQVGIEIHSGKNRIVRRIFESLGYRVVKLDRVMFAGLTKKNVRRGDWRFLTE 543


>UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter RepID=Q6F9V5_ACIAD
          Length = 239

 Score = 80.5 bits (197), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 60/215 (27%), Positives = 100/215 (46%), Gaps = 21/215 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKP--YDVLPQ-FTDEAGRKT 62
           I +   +   +R H +  F+ Q   +     +   +IL NKP  ++   Q    ++    
Sbjct: 33  IQDEIQKDLKYRIHDLTDFNFQVFDQNYVYREKVYIIL-NKPKGFECSHQPHHHQSVFSL 91

Query: 63  LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
           L + +  + + A GRLD+D+ GLL+LT++G     LT P K   K+Y+V           
Sbjct: 92  LPDLLIQRNIAAVGRLDQDTTGLLLLTDDGQYLHTLTHPKKHVPKVYHV----------- 140

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
            A  + +T++    L  G EL +E       N  +     +  + L +T+++G   QV+R
Sbjct: 141 -ATIDPITVDQMHQLEQGVELHNEKGVFAATNVTL-----LNETQLSMTIHQGVYHQVKR 194

Query: 183 MTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           M A VG     L R+ +G   L NLA GEW  +T+
Sbjct: 195 MIAAVGNKVTALHRHKIGQLELPNLAEGEWMYLTE 229


>UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SBU8_LEPBA
          Length = 243

 Score = 80.5 bits (197), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 59/182 (32%), Positives = 91/182 (50%), Gaps = 23/182 (12%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQAR 97
            + NK  D +   T++   KT+ +++  +     ++  GRLD+++EGLL+ T +G L   
Sbjct: 65  FMMNKAPDCITA-TEDPREKTVMDYLSERHRNMNLFPIGRLDKETEGLLLFTTDGTLAHY 123

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPP 156
            T P     K YY ++    T   +    +G+TL+DG  TLPA   + D      P NP 
Sbjct: 124 YTSPKHFVEKEYYAEISAPVTAFDISQFESGITLDDGYKTLPARLAIPD------PSNP- 176

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
                 I T WL+    EG+ RQ+RRM   +G     L R  MG+  LD +L  G +RE+
Sbjct: 177 -----HIATVWLR----EGKYRQIRRMFQSLGKEVQYLKRVKMGNLELDRDLEVGSYREL 227

Query: 216 TD 217
           T+
Sbjct: 228 TE 229


>UniRef50_Q30NZ7 Pseudouridine synthase n=3 Tax=Campylobacterales RepID=Q30NZ7_SULDN
          Length = 228

 Score = 80.1 bits (196), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 59/185 (31%), Positives = 88/185 (47%), Gaps = 30/185 (16%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQ------GVYAAGRLDRDSEGLLVLTNNGAL 94
           VIL NKP+ V+   +D      +   +P +       V   GRLD D+ G ++L+++GAL
Sbjct: 64  VILMNKPHGVVCSHSDSG--VLIYSLLPPRWQRRNPKVSTIGRLDIDTTGAILLSDDGAL 121

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG---PTLPAGAELVDEPAWLW 151
             +LT P     KIY V +      D  E   +G  L +G   P LPA  E++       
Sbjct: 122 NHKLTSPKSEVTKIYEVTLAQALRGDEAEIFASGELLLNGEKKPLLPAKMEVIG------ 175

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
               PI  R         + + EGR  QV+RM A VG     L R + GD+S+++L   E
Sbjct: 176 ----PIHVR---------VEICEGRYHQVKRMFASVGNRVTALHRASFGDFSVEDLKPSE 222

Query: 212 WREVT 216
           +RE++
Sbjct: 223 FREIS 227


>UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae RepID=Q7MMX9_VIBVY
          Length = 347

 Score = 80.1 bits (196), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 46/146 (31%), Positives = 79/146 (54%), Gaps = 19/146 (13%)

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           ++  GRLD+ S+GL+ LTN+G +  ++ + G    K Y V+V+   T + ++A+ +GV +
Sbjct: 98  IFPIGRLDKPSDGLIFLTNDGDIVNKILRAGNHHEKEYVVRVDKPITPEFIKAMSSGVNI 157

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
            D  TLP   ++  E  + +                 +I L +G NRQ+RRM   +G+  
Sbjct: 158 LDTVTLP--CKVTQETKFSF-----------------RIVLTQGLNRQIRRMCEALGYEV 198

Query: 192 LRLIRYAMGDYSLDNLANGEWREVTD 217
            +L R  + + SLD + NG+WR +TD
Sbjct: 199 FKLRRVRIMNISLDGIPNGKWRYLTD 224


>UniRef50_D0L0G8 Pseudouridine synthase n=1 Tax=Halothiobacillus neapolitanus c2
           RepID=D0L0G8_HALNC
          Length = 369

 Score = 80.1 bits (196), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 59/173 (34%), Positives = 83/173 (47%), Gaps = 28/173 (16%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVY-AAGRLDRDSEGLLVLTNNGALQA 96
           RVI+++KP   +   +D  GR T+   +P   QG +   GRLD ++ GLL+ TN+G L  
Sbjct: 66  RVIIYHKPEGEITSTSDPEGRPTVFGSLPAIRQGRWITVGRLDFNTSGLLLATNDGELAN 125

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT-----LPAGAELVDEPAWLW 151
           RL  P  +  + Y V+V G  T+D ++ L   V L+DGP        AG   V+      
Sbjct: 126 RLMHPSHQIERTYAVRVLGGLTEDQVKQLTTEVQLDDGPAHFDQLSDAGGTGVNR----- 180

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                          W  +TL EGRNR++RRM   VG    RLIR +     L
Sbjct: 181 ---------------WYHVTLREGRNREIRRMIEAVGAVVSRLIRISYAGIPL 218


>UniRef50_Q4Z2R8 Pseudouridine synthetase, putative n=3 Tax=Plasmodium (Vinckeia)
           RepID=Q4Z2R8_PLABE
          Length = 318

 Score = 80.1 bits (196), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 58/189 (30%), Positives = 95/189 (50%), Gaps = 21/189 (11%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQG--VYAAGRLDRDSEGLLVLTNNGALQA 96
           I+ +KP  ++    DE  RK++    P   +Q   + + GRLDR++ G+L+ TN      
Sbjct: 125 IVMHKPKGLICTNQDEKDRKSIFSIFPDDLLQKYRIVSVGRLDRNTSGVLLFTNEYTWVN 184

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND--------GPTLPAGAELVDEPA 148
           +LT P     + Y + +EG    DAL+ L NGV L D          T PA  E++ E  
Sbjct: 185 KLTHPKYERVRKYMIHIEGPVRMDALKMLANGVYLKDEDNNKKKKKKTQPAFIEVLREE- 243

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                N  I+ +     + L I++ EGRNRQ+R+M   +  P +++ R A  + +L N+ 
Sbjct: 244 -----NVKIQNQIK-KITVLNISIKEGRNRQIRKMFQQINQPIVKIKRTAFENITLKNIH 297

Query: 209 N-GEWREVT 216
              ++RE+T
Sbjct: 298 LPKQYRELT 306


>UniRef50_C7RHU0 Pseudouridine synthase n=3 Tax=Anaerococcus RepID=C7RHU0_ANAPD
          Length = 233

 Score = 80.1 bits (196), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 45/145 (31%), Positives = 75/145 (51%), Gaps = 18/145 (12%)

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           Q  +AAGRLD+DSEGLL++TN+G    ++  P K+  K Y V+V  +  ++  +   +G+
Sbjct: 91  QRFFAAGRLDKDSEGLLIITNDGIFTNQIIHPSKKLDKTYIVRVSRLLNKEECQQFESGI 150

Query: 130 TLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVG 188
            + D   T  +  EL+D+ +  +                 K+T+++G NRQ+RRM A+  
Sbjct: 151 DIGDSEMTSDSRIELIDKTSKTY-----------------KVTIHQGYNRQIRRMFAYFS 193

Query: 189 FPTLRLIRYAMGDYSLDNLANGEWR 213
                L R ++G   LD +   E R
Sbjct: 194 SEVKMLKRISIGPIKLDGMKPYEKR 218


>UniRef50_Q2G8T2 Pseudouridine synthase n=5 Tax=Sphingomonadales RepID=Q2G8T2_NOVAD
          Length = 270

 Score = 79.7 bits (195), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 59/185 (31%), Positives = 89/185 (48%), Gaps = 23/185 (12%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKT----LKEFIPVQG---VYAAGRLDRDSEGLLVLTN 90
           P R+  F+KP  ++    D  GR T    L+  +P QG   V   GRLD ++EGLL++TN
Sbjct: 87  PPRLFRFHKPSGLITAERDPTGRPTIYTALRNALP-QGTPRVMPVGRLDVNTEGLLLMTN 145

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L+  L  P     + Y  +  G  +Q  LE L  G+ ++        A L       
Sbjct: 146 DGELKRALELPSTGIPRTYRARTFGDISQARLEELMEGIEIDGVRYGSINANL------- 198

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                   ER +    W+++TL EG+NR+VRR+  H+G    RL+R   G + L +L  G
Sbjct: 199 --------ERSAGRNKWIELTLTEGKNREVRRVLEHLGLQVSRLLRTKYGPFELADLPRG 250

Query: 211 EWREV 215
              E+
Sbjct: 251 AAEEI 255


>UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteria
           RepID=A9ITY6_BORPD
          Length = 588

 Score = 79.7 bits (195), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 58/183 (31%), Positives = 83/183 (45%), Gaps = 19/183 (10%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGA 93
           +P RVIL++KP   +    D  GR ++   +P        + GRLD ++EGLL+ T +G 
Sbjct: 182 KPPRVILYHKPAGEIVSHDDPGGRASVFARLPKLRTGKWLSVGRLDLNTEGLLIFTTSGD 241

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           +  R+  P   T + Y V+V G       ++L  G+ L DG       + +         
Sbjct: 242 MANRIMHPRYGTEREYAVRVLGEMDDATRKSLVEGIELEDGQAAFGALDYLGGDG----- 296

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEW 212
                        W ++TL EGRNR+VRRM   VG    RLIR   GD  L   L  G W
Sbjct: 297 ----------SNRWYRVTLQEGRNREVRRMFESVGVTVSRLIRTRFGDLVLPRTLRRGRW 346

Query: 213 REV 215
            E+
Sbjct: 347 EEL 349


>UniRef50_A1S9T3 Pseudouridine synthase n=1 Tax=Shewanella amazonensis SB2B
           RepID=A1S9T3_SHEAM
          Length = 254

 Score = 79.3 bits (194), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 59/202 (29%), Positives = 91/202 (45%), Gaps = 12/202 (5%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRV---ILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYA 74
           +H  + F S R T       P +     L++KP  +  +   E     +        ++ 
Sbjct: 44  SHSDRVFDSNRVTVDGAPLCPAQAKAYFLYHKPVGIDCRLRAEDPHSLIHCLPGDLRLFP 103

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
           AGRLD+DS GLL+LTN+G L  RL  P     K Y + +   P  D + A+  G    +G
Sbjct: 104 AGRLDKDSRGLLLLTNDGELTQRLMHPDFHHQKGYLITLNKAPQPDDIAAIAAGFDYGEG 163

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
           PT P   E   +  +      P   RK      L++ L EG+ RQ+RR+    G+  L L
Sbjct: 164 PTRPCVVEAAIDCGYATEDGNP---RK------LRMRLTEGKKRQIRRLWRARGYRVLDL 214

Query: 195 IRYAMGDYSLDNLANGEWREVT 216
           +R ++   ++  L  GE R +T
Sbjct: 215 LRESIQQLNIGKLEQGEIRSLT 236


>UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales RepID=A6LIA0_PARD8
          Length = 495

 Score = 79.3 bits (194), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 51/179 (28%), Positives = 85/179 (47%), Gaps = 19/179 (10%)

Query: 42  ILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           I+ NKP + +    D   R T+ + +     + +Y  GRLDR++ G+L+LTN+G L ++L
Sbjct: 321 IVLNKPKNCVTTSDDPQERLTVMDLVKNACQERIYPVGRLDRNTTGVLLLTNDGDLASKL 380

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P  +  KIY+V ++     + +E + NG+ L DG           E            
Sbjct: 381 THPSFKKKKIYHVWLDKNVAIEDMEKIANGLELEDGEIHADAISYASEDD---------- 430

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
                  S + I ++ GRNR VRR+   +G+   +L R      +  NL  G+WR + +
Sbjct: 431 ------KSQVGIEIHSGRNRIVRRIFESLGYHVTKLDRVYFAGLTKKNLGRGKWRYLNE 483


>UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (class)
           RepID=B0RHF4_CLAMS
          Length = 291

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 57/179 (31%), Positives = 80/179 (44%), Gaps = 17/179 (9%)

Query: 40  RVILFNKPYDVLPQFTDEAGR--KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           R ++ NKP  +     DE GR           + ++  GRLD ++ GLL+LTN+G L   
Sbjct: 86  RYLMLNKPVGIYSSLRDERGRPDLREFTEEFEERLFNVGRLDAETSGLLILTNDGDLAHV 145

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           L  P     K Y  +V G  T   ++ L  GV L DGP     A ++             
Sbjct: 146 LAHPSFGVLKTYIAKVTGRVTPQTIQRLTQGVDLEDGPIQADRARILSGGG--------- 196

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                   + ++ITL+ GRNR VRRM   VG P   L+R   G   L +L  G  R++T
Sbjct: 197 ------DQTLVEITLHSGRNRIVRRMLDEVGHPVEELVRRQFGPLHLGSLGVGRVRDLT 249


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E...   293   4e-78
UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E...   249   4e-65
UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E...   246   4e-64
UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E...   246   5e-64
UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E...   241   9e-63
UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae ...   236   3e-61
UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E...   236   3e-61
UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testost...   230   2e-59
UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandens...   230   3e-59
UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q...   227   2e-58
UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella dranco...   226   3e-58
UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3...   226   4e-58
UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadale...   225   8e-58
UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr06...   224   1e-57
UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyr...   224   2e-57
UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B...   224   2e-57
UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibac...   223   3e-57
UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q...   221   1e-56
UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=...   220   3e-56
UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta...   219   4e-56
UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp....   219   6e-56
UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae...   219   7e-56
UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   216   4e-55
UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumo...   215   8e-55
UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8...   214   1e-54
UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium c...   214   2e-54
UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   214   2e-54
UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=...   214   2e-54
UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   214   2e-54
UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   213   4e-54
UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B...   211   1e-53
UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...   211   1e-53
UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q2...   210   3e-53
UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   210   3e-53
UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter Re...   210   3e-53
UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   210   3e-53
UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   209   4e-53
UniRef50_P0AA45 Ribosomal small subunit pseudouridine synthase A...   209   5e-53
UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wo...   209   7e-53
UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales R...   208   8e-53
UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria ...   208   8e-53
UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   208   8e-53
UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine syn...   208   1e-52
UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   207   2e-52
UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   207   2e-52
UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   207   2e-52
UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia ...   207   2e-52
UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   206   3e-52
UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroid...   206   4e-52
UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   206   6e-52
UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula m...   205   6e-52
UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   205   7e-52
UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9...   205   9e-52
UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succi...   205   1e-51
UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gin...   205   1e-51
UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0...   204   1e-51
UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=...   204   1e-51
UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3...   204   1e-51
UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A...   204   1e-51
UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter hepari...   204   1e-51
UniRef50_Q12AB3 Pseudouridine synthase n=8 Tax=Proteobacteria Re...   204   2e-51
UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueg...   204   2e-51
UniRef50_A1WE21 Pseudouridine synthase n=1 Tax=Verminephrobacter...   203   3e-51
UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepI...   203   3e-51
UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5...   203   3e-51
UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes Rep...   203   3e-51
UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium r...   203   4e-51
UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales Re...   203   4e-51
UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   203   5e-51
UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae Rep...   202   6e-51
UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organism...   202   6e-51
UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5...   202   6e-51
UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E...   201   1e-50
UniRef50_Q8ZGM2 Ribosomal small subunit pseudouridine synthase A...   201   1e-50
UniRef50_Q1LLR3 Pseudouridine synthase n=15 Tax=Proteobacteria R...   201   1e-50
UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   201   1e-50
UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter Re...   201   1e-50
UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   201   1e-50
UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria Rep...   201   1e-50
UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales ...   201   2e-50
UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   201   2e-50
UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredi...   201   2e-50
UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   201   2e-50
UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   201   2e-50
UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutac...   201   2e-50
UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomona...   200   2e-50
UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   200   2e-50
UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   200   2e-50
UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter the...   200   2e-50
UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termit...   200   3e-50
UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepI...   200   3e-50
UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium Rep...   199   3e-50
UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax...   199   4e-50
UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae...   199   4e-50
UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C...   199   4e-50
UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine...   199   4e-50
UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapol...   199   5e-50
UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q...   199   5e-50
UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae...   199   5e-50
UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales Rep...   199   5e-50
UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_14...   199   5e-50
UniRef50_Q38VQ0 Pseudouridine synthase n=6 Tax=Lactobacillus Rep...   199   7e-50
UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales Rep...   199   7e-50
UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales R...   199   7e-50
UniRef50_A3JIZ1 Pseudouridine synthase n=1 Tax=Marinobacter sp. ...   198   8e-50
UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacter...   198   1e-49
UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae ...   198   1e-49
UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72...   198   1e-49
UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B...   198   1e-49
UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi A...   198   1e-49
UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr03...   198   1e-49
UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria R...   198   1e-49
UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uen...   198   2e-49
UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   198   2e-49
UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (...   198   2e-49
UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1...   198   2e-49
UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1...   198   2e-49
UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrional...   197   2e-49
UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q0...   197   2e-49
UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limn...   197   2e-49
UniRef50_P45104 Ribosomal large subunit pseudouridine synthase B...   197   2e-49
UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2...   197   2e-49
UniRef50_A3HY40 Pseudouridine synthase n=1 Tax=Algoriphagus sp. ...   197   2e-49
UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae Rep...   197   2e-49
UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacter...   196   3e-49
UniRef50_C3X1E1 Pseudouridine synthase n=2 Tax=Oxalobacter formi...   196   6e-49
UniRef50_C5CXG1 Pseudouridine synthase n=4 Tax=Comamonadaceae Re...   195   7e-49
UniRef50_C7I043 Pseudouridine synthase n=4 Tax=Proteobacteria Re...   195   7e-49
UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   195   8e-49
UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteri...   195   8e-49
UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae Re...   195   8e-49
UniRef50_Q2W4E4 Pseudouridine synthase n=20 Tax=cellular organis...   195   9e-49
UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   195   1e-48
UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales R...   194   1e-48
UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine syn...   194   1e-48
UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdello...   194   1e-48
UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   194   2e-48
UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytop...   194   2e-48
UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   194   2e-48
UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacter...   194   2e-48
UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium Re...   194   2e-48
UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacte...   193   3e-48
UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marin...   193   3e-48
UniRef50_Q4FV02 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   193   3e-48
UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6...   193   3e-48
UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus Re...   193   4e-48
UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus Re...   193   5e-48
UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID...   192   6e-48
UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ...   192   6e-48
UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi...   192   7e-48
UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterinea...   192   7e-48
UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID...   192   8e-48
UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria Re...   192   8e-48
UniRef50_C6X4T2 Pseudouridine synthase n=2 Tax=Flavobacteriaceae...   191   9e-48
UniRef50_A9KPL1 Pseudouridine synthase n=63 Tax=Bacteria RepID=A...   191   1e-47
UniRef50_B4D966 Pseudouridine synthase n=1 Tax=Chthoniobacter fl...   191   1e-47
UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3...   191   1e-47
UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   191   1e-47
UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   191   1e-47
UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID...   191   2e-47
UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter rube...   191   2e-47
UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae Re...   191   2e-47
UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracel...   191   2e-47
UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   191   2e-47
UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus...   190   2e-47
UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vag...   190   2e-47
UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus m...   190   2e-47
UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID...   190   2e-47
UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0...   190   2e-47
UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae ...   190   2e-47
UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=...   190   3e-47
UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   190   3e-47
UniRef50_Q9HZ55 Ribosomal large subunit pseudouridine synthase B...   189   4e-47
UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. ...   189   4e-47
UniRef50_C1DA59 Pseudouridine synthase n=6 Tax=Betaproteobacteri...   189   4e-47
UniRef50_UPI0001C37AA4 16s pseudouridylate synthase n=2 Tax=Rumi...   189   4e-47
UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodi...   189   5e-47
UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5...   189   5e-47
UniRef50_B2V6W2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B2...   189   5e-47
UniRef50_C3BQR1 Pseudouridine synthase n=3 Tax=Bacillus RepID=C3...   189   6e-47
UniRef50_Q9I5J6 Ribosomal small subunit pseudouridine synthase A...   189   6e-47
UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum v...   189   7e-47
UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   189   8e-47
UniRef50_Q2NSN0 Pseudouridine synthase n=7 Tax=Gammaproteobacter...   188   9e-47
UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=...   188   1e-46
UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus...   188   1e-46
UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin51...   188   1e-46
UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=...   188   1e-46
UniRef50_C9LMF3 Ribosomal small subunit pseudouridine synthase A...   188   1e-46
UniRef50_A5TW76 Pseudouridine synthase n=11 Tax=Fusobacterium Re...   188   1e-46
UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacter...   188   1e-46
UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum fe...   188   1e-46
UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actino...   188   1e-46
UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella el...   188   1e-46
UniRef50_A8S8D3 Pseudouridine synthase n=1 Tax=Faecalibacterium ...   188   1e-46
UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indi...   188   2e-46
UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organism...   187   2e-46
UniRef50_C0W3E8 Pseudouridine synthase n=1 Tax=Actinomyces uroge...   187   2e-46
UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis...   187   2e-46
UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus...   187   2e-46
UniRef50_C6W5I1 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...   187   2e-46
UniRef50_A9KNY1 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   187   2e-46
UniRef50_A5Z4I7 Pseudouridine synthase n=1 Tax=Eubacterium ventr...   187   2e-46
UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium R...   187   2e-46
UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepI...   187   2e-46
UniRef50_Q14P18 Pseudouridine synthase n=2 Tax=Mollicutes RepID=...   187   2e-46
UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   187   3e-46
UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silv...   186   4e-46
UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis exc...   186   5e-46
UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae Rep...   186   5e-46
UniRef50_UPI0001C337CA ribosomal large subunit pseudouridine syn...   186   6e-46
UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gas...   186   6e-46
UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacte...   186   6e-46
UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflex...   186   7e-46
UniRef50_O32068 Uncharacterized RNA pseudouridine synthase ytzG ...   185   7e-46
UniRef50_C2KV26 Pseudouridylate synthase n=1 Tax=Oribacterium si...   185   8e-46
UniRef50_B9JSE7 Ribosomal large subunit pseudouridine synthase B...   185   8e-46
UniRef50_B6BUN1 Pseudouridine synthase n=1 Tax=beta proteobacter...   185   8e-46
UniRef50_D0SB72 Pseudouridine synthase n=5 Tax=Acinetobacter Rep...   185   8e-46
UniRef50_Q2NZN4 Pseudouridine synthase n=13 Tax=Xanthomonadaceae...   185   9e-46
UniRef50_B3DRY9 Pseudouridine synthase n=7 Tax=Bifidobacterium R...   185   9e-46
UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q1...   185   1e-45
UniRef50_Q1YVK2 Pseudouridine synthase n=3 Tax=Gammaproteobacter...   185   1e-45
UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alex...   184   1e-45
UniRef50_C7NBL1 Pseudouridine synthase n=3 Tax=Leptotrichia RepI...   184   1e-45
UniRef50_A1U6Q2 Pseudouridine synthase n=4 Tax=Gammaproteobacter...   184   1e-45
UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (c...   184   2e-45
UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas Rep...   184   2e-45
UniRef50_A6DMJ6 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   184   2e-45
UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii ...   184   2e-45
UniRef50_A8ZRV1 Pseudouridine synthase n=3 Tax=Desulfobacteracea...   184   2e-45
UniRef50_A8I6C3 Pseudouridine synthase n=6 Tax=Alphaproteobacter...   184   2e-45
UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna ...   183   3e-45
UniRef50_B2HUK5 Pseudouridine synthase n=9 Tax=Gammaproteobacter...   183   3e-45
UniRef50_A5ZYR1 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   183   3e-45
UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovib...   183   3e-45
UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K...   183   3e-45
UniRef50_A3JEU2 Pseudouridine synthase n=2 Tax=Marinobacter RepI...   183   4e-45
UniRef50_C7PFL3 Pseudouridine synthase n=3 Tax=Bacteria RepID=C7...   183   4e-45
UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenen...   183   4e-45
UniRef50_A6WK95 Pseudouridine synthase n=12 Tax=Gammaproteobacte...   183   5e-45
UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1...   183   5e-45
UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium fe...   183   6e-45
UniRef50_Q04F57 Pseudouridine synthase n=2 Tax=Oenococcus oeni R...   182   6e-45
UniRef50_UPI0001745920 putative pseudouridylate synthase n=1 Tax...   182   7e-45
UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae ...   182   8e-45
UniRef50_B8DUD9 Pseudouridine synthase n=8 Tax=Bifidobacterium R...   182   8e-45
UniRef50_C0EB54 Pseudouridine synthase n=1 Tax=Clostridium methy...   182   8e-45
UniRef50_Q87NB7 Ribosomal large subunit pseudouridine synthase B...   182   9e-45
UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9...   181   1e-44

Sequences not found previously or not previously below threshold:

>UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Enterobacteriaceae RepID=RLUE_SALTY
          Length = 221

 Score =  293 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 179/215 (83%), Positives = 198/215 (92%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           MRQ I SENTMQKTSFRNH VKRFSS+++++ + ENQP RV+LFNKPYDVLPQFTDEAGR
Sbjct: 1   MRQLISSENTMQKTSFRNHYVKRFSSRQASKSRKENQPKRVVLFNKPYDVLPQFTDEAGR 60

Query: 61  KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +TLK+FIPVQGVYAAGRLDRDSEGLLVLTN+GALQARLTQPGKRTGKIYYVQVEGIP   
Sbjct: 61  RTLKDFIPVQGVYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGIPDNA 120

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           AL+ALR GVTLNDGPTLPAG E+V EP WLWPR PPIRERK+IPTSWLK+TLYEGRNRQV
Sbjct: 121 ALQALRTGVTLNDGPTLPAGIEIVAEPDWLWPRTPPIRERKNIPTSWLKVTLYEGRNRQV 180

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RRMTAHVG PTLRLIRY+MGDY+L+ L NG+WRE+
Sbjct: 181 RRMTAHVGHPTLRLIRYSMGDYTLNGLDNGQWREI 215


>UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E n=61 Tax=Bacteria
           RepID=RLUE_PASMU
          Length = 241

 Score =  249 bits (637), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 127/219 (57%), Positives = 155/219 (70%), Gaps = 13/219 (5%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQP-------------TRVILFNKPYDVLPQFTDEA 58
           QKT  R   ++  + +++   KP+ +P             T+VILFNKPYDVL QF+DE 
Sbjct: 9   QKTKPRPSSLRSVNKRKAAEIKPQKRPLSFRQKKTVNFAETQVILFNKPYDVLTQFSDEE 68

Query: 59  GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           GR TLK FIP+  VY AGRLDRDSEGL++LTNNG +Q RL  P   T K Y+ QVEGIP 
Sbjct: 69  GRATLKAFIPIPHVYPAGRLDRDSEGLVLLTNNGEIQHRLAVPKFNTEKTYFAQVEGIPQ 128

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           +  L  LR GV LNDG TLPA   LV EP WLW RNPPIRERK IPTSWL+I ++EGRNR
Sbjct: 129 ETDLAQLRQGVVLNDGKTLPAKVRLVPEPNWLWQRNPPIRERKQIPTSWLEIKIHEGRNR 188

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           QVRRMTAH+GFPTLRLIRY M  ++L NL  G++R++++
Sbjct: 189 QVRRMTAHIGFPTLRLIRYQMALFNLANLEQGQYRQLSE 227


>UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E n=107 Tax=Bacteria
           RepID=RLUE_VIBCH
          Length = 241

 Score =  246 bits (629), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 130/202 (64%), Positives = 155/202 (76%), Gaps = 1/202 (0%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYA 74
           S  N +     +  S +R       +VILFNKPYD L QFTD  GRKTL ++IP++ VYA
Sbjct: 40  SVANKKKNATQTALSPKRPLSPAERKVILFNKPYDTLSQFTDGDGRKTLADYIPIKDVYA 99

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
           AGRLDRDSEGLL+LTN+G LQARLTQP  +  K Y+VQVEG P +  LEALR+GVTL DG
Sbjct: 100 AGRLDRDSEGLLILTNDGILQARLTQPQSKAPKTYWVQVEGSPQESDLEALRHGVTLKDG 159

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
           PTLPA  +++ EP  LWPRNPP+R R +IPT+WL ITL EGRNRQVRRMTAH+GFPTLRL
Sbjct: 160 PTLPAKVDIMPEP-TLWPRNPPVRFRAAIPTTWLAITLMEGRNRQVRRMTAHIGFPTLRL 218

Query: 195 IRYAMGDYSLDNLANGEWREVT 216
           IRY+MGD++L +L  GEWREVT
Sbjct: 219 IRYSMGDWNLGDLQPGEWREVT 240


>UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Proteobacteria RepID=RLUE_PSEAE
          Length = 189

 Score =  246 bits (628), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 118/183 (64%), Positives = 139/183 (75%), Gaps = 1/183 (0%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNG 92
           K      +++LFNKP+DVL QF DE GR TLK+FIPV GVY AGRLDRDSEGLL+LTN+G
Sbjct: 3   KAPPSEPKLLLFNKPFDVLTQFNDEQGRSTLKDFIPVPGVYPAGRLDRDSEGLLLLTNDG 62

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            LQAR+  P  +  K Y+VQVEG P ++ L  LR GVTLNDGPTLPA A L+DEP  LW 
Sbjct: 63  RLQARIADPRHKLPKTYWVQVEGTPDEEQLRRLREGVTLNDGPTLPAEARLLDEP-TLWE 121

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           R PP+R RKS+PT WL++ + EGRNRQVRRMTA VG PTLRL+R  +G +SLD L  GEW
Sbjct: 122 RVPPVRFRKSVPTHWLELVIREGRNRQVRRMTAAVGLPTLRLVRVRIGPWSLDGLGLGEW 181

Query: 213 REV 215
           REV
Sbjct: 182 REV 184


>UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E n=26 Tax=Bacteria
           RepID=Q1QUR9_CHRSD
          Length = 257

 Score =  241 bits (617), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 104/183 (56%), Positives = 129/183 (70%), Gaps = 1/183 (0%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
           P    + + L +KPY +L QFTD  GR TL E I V  +Y AGRLD DSEGLL+LT +GA
Sbjct: 55  PRPPMSSLYLLHKPYQMLSQFTDTRGRATLAEAIDVPDIYPAGRLDYDSEGLLLLTGDGA 114

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  R++ P  +  K Y+VQVEG P   AL+ALR GVTL DGPT PA    ++ P  + PR
Sbjct: 115 LAHRISHPRHKQPKTYWVQVEGEPEPAALQALRQGVTLRDGPTRPAKVRRLESPD-VAPR 173

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           +PP+R R+++PT+WL++TL EGRNRQVRRMTAHVG PTLRLIR A+G + L  LA GEWR
Sbjct: 174 HPPVRHREAVPTAWLELTLSEGRNRQVRRMTAHVGHPTLRLIRVAIGSWHLAGLAPGEWR 233

Query: 214 EVT 216
             T
Sbjct: 234 RET 236


>UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae RepID=B3GZS7_ACTP7
          Length = 232

 Score =  236 bits (604), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 110/211 (52%), Positives = 141/211 (66%), Gaps = 6/211 (2%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPEN-----QPTRVILFNKPYDVLPQFTDEAGRKTLKEF 66
           QK   R+   K  + Q  T+++P       + T V+LFNKP+DVL QFTDE GR+TLK+F
Sbjct: 9   QKNKPRSATNKP-NLQNRTKKRPLKLQLSFEDTVVVLFNKPFDVLTQFTDEQGRQTLKDF 67

Query: 67  IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALR 126
           IP+  +Y  GRLDRDSEGLL+LTNNG +Q RL  P     K Y  QVEGIP    L  L 
Sbjct: 68  IPIPQIYPVGRLDRDSEGLLLLTNNGEIQHRLANPKFEKQKTYLAQVEGIPQAADLAKLE 127

Query: 127 NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
            GV L DG T PA A+ +  P + W   P IRERK+IPTSW+++ ++EG+NRQVRRMTAH
Sbjct: 128 KGVELKDGLTKPAKAKAISAPNYEWQTAPKIRERKTIPTSWIELKIHEGKNRQVRRMTAH 187

Query: 187 VGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +GFPTLRLIR  +G + L  L +GE+R + +
Sbjct: 188 IGFPTLRLIRIGLGQFQLGELNSGEYRVLDE 218


>UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E n=244 Tax=Bacteria
           RepID=RLUE_VIBPA
          Length = 238

 Score =  236 bits (604), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 115/179 (64%), Positives = 143/179 (79%), Gaps = 1/179 (0%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQA 96
           Q  +VI+FNKPYD L QFTD  GRKTL ++IPV+ VYAAGRLDRDSEGL+VLTN+G LQA
Sbjct: 59  QNRKVIIFNKPYDTLSQFTDGDGRKTLADYIPVKDVYAAGRLDRDSEGLMVLTNDGILQA 118

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           +LTQP  ++ K Y+VQV+G P +  LE LR GV L DG TLPA  E++D P  +W RNPP
Sbjct: 119 KLTQPKSKSPKTYWVQVDGAPQEQDLEKLRKGVELKDGMTLPAKVEVIDAP-TIWERNPP 177

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +R R +IPT+WL IT+ EGRNRQVRRMTAH+GFPTLRL+RY+MGD +L +L  G+W+E+
Sbjct: 178 VRFRANIPTTWLAITIIEGRNRQVRRMTAHIGFPTLRLVRYSMGDITLGDLQPGQWKEI 236


>UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testosteroni
           RepID=D0IWI1_COMTE
          Length = 223

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 110/200 (55%), Positives = 142/200 (71%), Gaps = 9/200 (4%)

Query: 22  KRFSSQRSTR-------RKPENQP--TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV 72
           + FSS RS+        R+P  +P  TR++ F+KPY VL QFT E   + LK++I V GV
Sbjct: 15  RPFSSNRSSNLRRSTVVRQPAPRPGVTRLLCFHKPYGVLSQFTPEGKWQGLKDWIDVPGV 74

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
           Y AGRLD DSEGLL+LTN+G LQAR+  P  +  K Y+VQVEGIP + AL+ LR GV L+
Sbjct: 75  YVAGRLDADSEGLLLLTNDGQLQARIADPRHKMEKTYWVQVEGIPDEAALQRLREGVELS 134

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
           DG TLPA A L++    +WPRNPPIR R++IP  W+++ + EGRNRQVRRMTA VG PTL
Sbjct: 135 DGKTLPAKARLIEPQPLMWPRNPPIRVRQNIPDCWIELIIREGRNRQVRRMTAAVGHPTL 194

Query: 193 RLIRYAMGDYSLDNLANGEW 212
           RL+R A+G YS++ L  G+W
Sbjct: 195 RLVRMAVGPYSIEGLEPGQW 214


>UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BDP6_9GAMM
          Length = 228

 Score =  230 bits (587), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 105/177 (59%), Positives = 134/177 (75%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +R +LFNKP+ VL QFTD   R+TL +FI V  VY+AGRLD DSEGLL+LT++GAL   +
Sbjct: 2   SRYLLFNKPFQVLTQFTDPDNRQTLADFIDVPEVYSAGRLDYDSEGLLLLTDDGALIHSM 61

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P  +T K Y  QVEG  T +A+  L +G+ L DGPTLPA A  V EPAWLWPR PPIR
Sbjct: 62  MNPRFKTPKTYLAQVEGDITDEAIRRLESGLQLKDGPTLPAKARRVSEPAWLWPRQPPIR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ER +IP SW+++TL EGRNRQVRRMTA VGFPTLRLIR A+ + ++++L+ G+++EV
Sbjct: 122 ERATIPASWVELTLVEGRNRQVRRMTAAVGFPTLRLIRVALAELTVESLSVGQYKEV 178


>UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q1GHH2_SILST
          Length = 221

 Score =  227 bits (579), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 112/181 (61%), Positives = 142/181 (78%), Gaps = 4/181 (2%)

Query: 39  TRVILFNKPYDVLPQFTDEAG----RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGAL 94
           +R+I FNKP+DVLPQFTD       R TL +++   GVY AGRLDRDSEGL++LT+NG L
Sbjct: 2   SRLIRFNKPFDVLPQFTDRGSEGSPRATLSDYVDCPGVYPAGRLDRDSEGLMLLTDNGRL 61

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
           QA ++ P  +  K Y+VQVEGIPT+DAL+ALR GV L DG T PA AEL+ EPA LW R 
Sbjct: 62  QAWISDPKHKLEKTYWVQVEGIPTEDALKALRQGVDLKDGMTRPAKAELISEPAQLWART 121

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
           PPIRERKS+PT+WL++ + EG+NRQVRRMTA +G+PTLRLIRYA+G ++LD LA G+W +
Sbjct: 122 PPIRERKSVPTAWLELKISEGKNRQVRRMTAAMGYPTLRLIRYAIGAWTLDGLAQGKWDD 181

Query: 215 V 215
           +
Sbjct: 182 L 182


>UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella drancourtii LLAP12
           RepID=C6MZI4_9GAMM
          Length = 240

 Score =  226 bits (578), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 102/173 (58%), Positives = 126/173 (72%), Gaps = 1/173 (0%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +ILFNKP+ V+ QFT E    TL EFI     YAAGRLD++SEGLL+LTN+GALQ +LT 
Sbjct: 55  LILFNKPFAVVCQFTGEKHEHTLAEFIDKPDFYAAGRLDKNSEGLLLLTNDGALQHQLTH 114

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y+VQVEGIPT   LE L+ G+ L D   LPA    ++EPA LWPR PP+R R
Sbjct: 115 PKFNKKKYYWVQVEGIPTAADLEPLKKGLVLKDITFLPAEVRCIEEPA-LWPRTPPVRFR 173

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           +SIPTSWL+I L EG+N QVRRMTA +GFPTLRL+R+ +GD+ L +L  GE+R
Sbjct: 174 QSIPTSWLEIILREGKNHQVRRMTAAMGFPTLRLVRHRIGDWQLGDLQPGEFR 226


>UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3U4L2_9BACT
          Length = 420

 Score =  226 bits (577), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 69/217 (31%), Positives = 108/217 (49%), Gaps = 18/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  I+ + +++   +    +          +   QP   ++ NKP +V+    D  GR T
Sbjct: 28  RVTINGSVVKELGTKVDPARDHVKVDGKHLRAA-QPYVYLILNKPKNVMSTLDDPEGRPT 86

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +K+ +      V+  GRLD DSEGL++LTN+G L   L  P     K Y ++V+G+    
Sbjct: 87  VKDLLHGVTVRVFPVGRLDFDSEGLMLLTNHGDLAQALLHPRYHVPKTYLIKVKGVLDDA 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +EAL  GV L DG T PA  + V                ++   SWL++T++EGR  QV
Sbjct: 147 KIEALERGVKLEDGFTAPAKVKKVS---------------RAESNSWLEVTIHEGRKHQV 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +RM   VG   ++L+R  MG   L +LA  E+R +TD
Sbjct: 192 KRMVEAVGHSVIKLVRVRMGPLLLGDLAPREYRFLTD 228


>UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadales
           RepID=B3E7C4_GEOLS
          Length = 274

 Score =  225 bits (574), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 102/216 (47%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   +    K   +      KP  +    +L +KP   +    D  GR+ 
Sbjct: 28  RVTVNGQVVTELGSKADPAKDLIALDGQPVKPA-ETFYYVLLHKPAGYVTSLKDPQGRQL 86

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + E +    + ++  GRLD +SEGLL+LTN+GA   RL  P  +  K Y+V+V G     
Sbjct: 87  VTELVKDVGERLFPVGRLDYNSEGLLLLTNDGAWANRLMHPRHQVDKEYHVRVRGKIDPQ 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            ++ L +GV L DGPT      L+               +      WL +T+ EGRNRQV
Sbjct: 147 QIKKLADGVELEDGPTGATTVRLL---------------KNDQSNDWLSVTIREGRNRQV 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM A VG   +RL R   G+ +L  L  GE+R ++
Sbjct: 192 RRMCAAVGLFVVRLRRIRYGNLTLGGLQPGEYRLLS 227


>UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr0612 n=16
           Tax=Bacteria RepID=Y612_SYNY3
          Length = 261

 Score =  224 bits (572), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 103/200 (51%), Positives = 128/200 (64%), Gaps = 20/200 (10%)

Query: 36  NQPTRVILFNKPYDVLPQFTDE--AGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
           N+  + I+F KPY VL QFTD     R TLK++I +  +Y  GRLD+DSEGLL+LT+NG 
Sbjct: 36  NKTPQTIVFYKPYGVLCQFTDNSAHPRPTLKDYINLPDLYPVGRLDQDSEGLLLLTSNGK 95

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           LQ RL        + Y+ QVEG PT + LE LR G+T  D PT PA A+++ EP +  PR
Sbjct: 96  LQHRLAHREFAHQRTYFAQVEGSPTDEDLEPLRRGITFADYPTRPAIAKIITEPDF-PPR 154

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM---------GD--- 201
           NPPIR R SIPTSWL ITL EGRNRQVRRMTA VGFPTLRL+R  +         G    
Sbjct: 155 NPPIRYRASIPTSWLSITLTEGRNRQVRRMTAAVGFPTLRLVRVQIQVTGRSPQQGKGKS 214

Query: 202 -----YSLDNLANGEWREVT 216
                 +L+ L+ G+WR +T
Sbjct: 215 AATWCLTLEGLSPGQWRPLT 234


>UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyrosolvens DSM 2782
           RepID=C7ICF2_9CLOT
          Length = 235

 Score =  224 bits (571), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 57/205 (27%), Positives = 100/205 (48%), Gaps = 21/205 (10%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGV 72
           +   + V     +  T  + +      I+ NKP   +    D+ GR  + + +    + +
Sbjct: 43  TVTCNDVVTVDGKPVTTEEAK----VYIMLNKPVGYVSTSKDQFGRPAVIDLVKDAGKRL 98

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
           Y  GRLD D+ GL++LTN+G    RLT P     K+Y   + G P ++ +     G+ ++
Sbjct: 99  YPVGRLDYDTSGLILLTNDGDFTYRLTHPKHEVNKVYEAVISGFPDKNEITRFETGLKID 158

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
           D  T PA  E++++                   + ++IT++EG+NRQVR+M   +G   L
Sbjct: 159 DYQTSPAEFEVLNKKGI---------------NTLVRITIHEGKNRQVRKMCEAIGHKVL 203

Query: 193 RLIRYAMGDYSLDNLANGEWREVTD 217
            L R  +G  +L+NL  G+WR ++D
Sbjct: 204 TLKRIQIGPIALENLPEGKWRHLSD 228


>UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B0TFD8_HELMI
          Length = 333

 Score =  224 bits (571), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 70/213 (32%), Positives = 101/213 (47%), Gaps = 18/213 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           I+   +++   R    +    +   R     +        KP  V+    D  GR+T+  
Sbjct: 34  INGTVVREQGVRVDGARDV-IEVDGRILKRREAPLYYALYKPRGVVTTCKDPQGRQTVIG 92

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +    + VY  GRLDRD+EGLL+LTN+G L  RLT P     K Y  ++ G  +  AL+
Sbjct: 93  LLSGVNERVYPVGRLDRDTEGLLLLTNDGQLAFRLTHPRFGVEKTYRARLRGDVSAGALK 152

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
           AL  GV L DG T PA   L+               R+    +W++I ++EGR RQ+RRM
Sbjct: 153 ALAEGVQLEDGVTAPAQVRLL---------------RREGDATWIEIKIHEGRKRQIRRM 197

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              +G P + L R A G  +L  L  GE R +T
Sbjct: 198 GDAIGHPVIDLERIAFGPITLGKLKPGEVRPLT 230


>UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibacillus larvae subsp. larvae
           BRL-230010 RepID=UPI0001693918
          Length = 249

 Score =  223 bits (569), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 76/205 (37%), Positives = 99/205 (48%), Gaps = 19/205 (9%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQ 70
                 HQ       +   R  +NQ    ILFNKP  V+   +D  GR+ + +F+    +
Sbjct: 40  GVKVNPHQ----DVIKVDGRAIQNQEKIYILFNKPKGVITSVSDPEGRRVVGDFLKGIKE 95

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            VY  GRLD D+EGLL+LTN+G     +T P     K Y+  V+G+P    LE LR GV 
Sbjct: 96  RVYPVGRLDYDTEGLLILTNDGEFANMVTHPRHHVSKTYHATVKGVPHGSVLEKLREGVK 155

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L DG T PA  E  D                    S + IT+YEG+NRQVRRM   VG+P
Sbjct: 156 LEDGMTAPAEVEYHDIDP-------------DKKQSVISITIYEGKNRQVRRMFEAVGYP 202

Query: 191 TLRLIRYAMGDYSLDNLANGEWREV 215
             RL R   G   L  L  G++R +
Sbjct: 203 VTRLKRVKFGSIPLVGLPRGKFRRM 227


>UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q2JQ37_SYNJB
          Length = 226

 Score =  221 bits (563), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 101/178 (56%), Positives = 128/178 (71%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           R + F KPY VL QFTD  GR TL+ FIPV  VY  GRLDRDSEGLL+LT++G L ARL 
Sbjct: 29  RYLKFYKPYGVLTQFTDREGRPTLQSFIPVPRVYPVGRLDRDSEGLLLLTDDGRLNARLI 88

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     +IY+VQVEGIPT  AL+ L+ G+ +    T PA  +++ E   L PR+PPIR 
Sbjct: 89  DPKFGHERIYWVQVEGIPTPQALQQLQQGLIIQGRKTRPAQVKVLAEEPTLPPRDPPIRF 148

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R+SIPT+WL++TL EGRNRQVRRMTA VG PTLRL+R  +G  SL  LA G+W+++++
Sbjct: 149 RRSIPTTWLELTLREGRNRQVRRMTAAVGIPTLRLVRVGLGPLSLAGLAPGQWQDLSE 206


>UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=A4J3M3_DESRM
          Length = 309

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 78/221 (35%), Positives = 111/221 (50%), Gaps = 22/221 (9%)

Query: 3   QFIISENTM---QKTSFRNHQVKRFSSQRSTRRKPEN--QPTRVILFNKPYDVLPQFTDE 57
           + IIS       +  +    +V     +   + KP    +    +L NKP   +   +DE
Sbjct: 22  ELIISGQVKVNGKTVTEMGLKVDPTKDKIEVKGKPLPPLEKKVYLLMNKPRGYVTTLSDE 81

Query: 58  AGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
             RKT+ + +    Q VY  GRLD DSEGLL+LTN+G L   LT P  +  K Y  +V+G
Sbjct: 82  RDRKTVVDLLKGVEQRVYPVGRLDYDSEGLLLLTNDGELTQALTHPKHKVKKTYLAKVDG 141

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
           IP  + L+A+  G+ L DGPT PA   L                      + L+I+++EG
Sbjct: 142 IPETEELKAMAKGLVLEDGPTAPADVRLAG---------------TGDNRALLEISIHEG 186

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RNRQVRRM  H+G+  LRL R  +G   L +L +GE R +T
Sbjct: 187 RNRQVRRMCEHIGYKVLRLRRTRIGTLELGSLKSGEVRALT 227


>UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WGQ8_EGGLE
          Length = 282

 Score =  219 bits (559), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 64/196 (32%), Positives = 94/196 (47%), Gaps = 19/196 (9%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQ 95
              I+ +KP   +   +D  GR+T+ E +P +    ++  GRLD D+ GLL+ + +G L 
Sbjct: 71  PVTIMLHKPAGFVTTMSDPQGRRTVAELVPTERYPGLFPIGRLDFDTTGLLLFSTDGELG 130

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE--------- 146
             L  P     K Y   VEG PT+  L  LR G+ L+DGPT PA   +V+          
Sbjct: 131 NGLLHPKHHVTKRYLACVEGRPTERDLALLRRGIELDDGPTQPADVRVVEGGAARHAERL 190

Query: 147 -------PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
                  P         + E ++   S +++ + EGR RQV+RM A VG P L L R + 
Sbjct: 191 LEIPAAVPPRSSKEYAAVCEGRATRRSIVRLGIREGRKRQVKRMLAAVGHPVLALHRDSF 250

Query: 200 GDYSLDNLANGEWREV 215
           G   L +L  G WR +
Sbjct: 251 GPLELGDLPRGAWRAL 266


>UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XK09_SYNP2
          Length = 223

 Score =  219 bits (558), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 96/184 (52%), Positives = 122/184 (66%), Gaps = 8/184 (4%)

Query: 41  VILFNKPYDVLPQFTD--EAG--RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQA 96
            +L +KPY+VL QFTD    G  R+TLK+F+PV  +Y+ GRLD DSEGLL+LTN+  L+ 
Sbjct: 5   YVLLHKPYNVLCQFTDNSPQGSQRQTLKDFVPVPDIYSVGRLDLDSEGLLLLTNDAPLKH 64

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
            L +P     + Y+VQVE IP   ALE LR GV +    T PA A L+     +  R PP
Sbjct: 65  YLCEPKFAHSRTYWVQVENIPDGQALEQLRQGVMVQGKKTRPAIANLLTPEPTVPAREPP 124

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG----DYSLDNLANGEW 212
           IR RK++PT+WL++TL EGRNRQVRRMTA VG PTLRL+R A+G      +L  L  GEW
Sbjct: 125 IRFRKNVPTAWLELTLTEGRNRQVRRMTAAVGHPTLRLMRVAIGAGPAKLTLTGLGPGEW 184

Query: 213 REVT 216
           R +T
Sbjct: 185 RHLT 188


>UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae RepID=C8WAL4_ATOPD
          Length = 279

 Score =  219 bits (558), Expect = 7e-56,   Method: Composition-based stats.
 Identities = 60/187 (32%), Positives = 89/187 (47%), Gaps = 6/187 (3%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGA 93
           +    ++ NKP   L    D  GR T+ + +P     G++  GRLD D+ GLL  T +G 
Sbjct: 67  EKPVYLMLNKPAGYLTTMKDPQGRPTIVDMVPTDTYPGLFPVGRLDMDTTGLLFFTTDGQ 126

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           +   L  P K   K Y   V G PT++ L  LR G+ L DGP  PA  E++ +   +   
Sbjct: 127 MAQELLHPSKHVWKHYVAHVVGTPTEEQLNRLREGIELEDGPAAPAEVEIISDDVKMKNL 186

Query: 154 NPPIRERKSI---PTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
             P    K+    P + + +T+ EGR  QV++M   +    L L R   G   L  +  G
Sbjct: 187 LAPQGLGKTGGGEPNALVSVTIREGRKHQVKKMLLAIHHRVLALHRDTFGPLHLTRVKEG 246

Query: 211 EWREVTD 217
           EWR +T+
Sbjct: 247 EWRLLTE 253


>UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=C8WXC0_ALIAD
          Length = 273

 Score =  216 bits (551), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 71/185 (38%), Positives = 99/185 (53%), Gaps = 14/185 (7%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNN 91
            E +   V++ NKP   L   +D  GR+T+ + +P   + VY  GRLD D+ GLL+ TN+
Sbjct: 56  IELEQPVVLVLNKPVAYLSTVSDPLGRRTVMQLLPPIRERVYPVGRLDYDTSGLLLFTND 115

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L  RL  P +   K+Y V V GI  ++   AL  GV L DG T PA  E++ +     
Sbjct: 116 GELTQRLLHPSREIEKVYRVSVRGIVDRETRRALMEGVELEDGVTAPAKVEVLRQAD--- 172

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                    +    + + + ++EGRNRQVRRM   +G P LRL R A G  SL +L  GE
Sbjct: 173 ---------REDGVAVVHLAIHEGRNRQVRRMFERLGLPVLRLKRIAFGPVSLGHLKTGE 223

Query: 212 WREVT 216
           WR +T
Sbjct: 224 WRALT 228


>UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumophila
           RepID=Q5ZXB8_LEGPH
          Length = 222

 Score =  215 bits (549), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 101/178 (56%), Positives = 128/178 (71%), Gaps = 1/178 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
            ++ILFNKPY +L QFT E   +TL  FI + G YAAGRLD+ SEGLL+LT++G LQ RL
Sbjct: 24  PQLILFNKPYGILTQFTGELPEQTLSAFIKLPGFYAAGRLDKQSEGLLILTDDGKLQHRL 83

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K Y+VQVEG+PT   L+ LR G+ + D   LPA A L+ EP  +WPR PPIR
Sbjct: 84  THPKFEKKKHYWVQVEGVPTDKDLQPLRKGLVIKDITFLPAEARLISEP-KIWPRIPPIR 142

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ERK IPT+WL+I L EG+N Q+R+MTA +GFPTLRLIRY +GD+ LD L  GE++ + 
Sbjct: 143 ERKHIPTTWLEIILREGKNHQIRKMTAAIGFPTLRLIRYQIGDWHLDQLQPGEYKLIN 200


>UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8G2X0_CHLAD
          Length = 567

 Score =  214 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 66/207 (31%), Positives = 97/207 (46%), Gaps = 18/207 (8%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTR--VILFNKPYDVLPQFTDEAGRKTLKEFIPVQ- 70
            +    +V     +     +P   P +   I+ +KP  V+    D  GR T+ + + V  
Sbjct: 37  VTVPGTRVDLEHDEVLVDGQPLRMPAKRTYIMLHKPAGVVSTAEDPHGRPTVVDLVDVPA 96

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            V+  GRLD DSEGL++LT++G L   LT P     K Y V ++   T DAL + RNGV 
Sbjct: 97  RVFPVGRLDLDSEGLILLTDDGELAYALTHPSFEVEKEYRVLLDRALTPDALRSWRNGVL 156

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L    T PA  EL++                +    W++I L EGR RQ+R +   +G+ 
Sbjct: 157 LEGEMTAPAWVELLE---------------TTPEGVWVRIVLREGRKRQIRAVAKLLGYE 201

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVTD 217
             RL+R   G   L +L    WR +TD
Sbjct: 202 VRRLVRVREGPLQLGDLPPRAWRHLTD 228


>UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium curtum DSM 15641
           RepID=C7MNA2_CRYCD
          Length = 296

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 58/181 (32%), Positives = 90/181 (49%), Gaps = 18/181 (9%)

Query: 38  PTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGAL 94
           P   +  NKP  ++    D  GR+ + + +P +   G++  GRLD+D+ GLL+ + +G L
Sbjct: 109 PAVTLALNKPAGIITTMKDLRGRRCVADIMPTEQYPGLFPIGRLDQDTTGLLLFSTDGNL 168

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              L  P     K+Y   +EG   Q ALE L +G+ L+DG T PA   +V          
Sbjct: 169 GNALLHPSHGVSKVYRATIEGSIGQAALEQLASGILLDDGMTAPARVSVV---------- 218

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                +     S +++ L+EGR  QV+RM   VG P ++L R + G   L  LA G +R 
Sbjct: 219 -----QAGKKHSVIELELHEGRKHQVKRMCQAVGHPVVKLHRASFGPIDLAGLATGAYRR 273

Query: 215 V 215
           +
Sbjct: 274 L 274


>UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CFA0_THET1
          Length = 253

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 80/198 (40%), Positives = 105/198 (53%), Gaps = 17/198 (8%)

Query: 22  KRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRKTLKEFI-PVQGVYAAGRLD 79
                 R   +    QP  R IL NKP  VL    DE GRKT+ + +     VY  GRLD
Sbjct: 46  SPEDEIRVDGKLVRQQPKMRYILLNKPAGVLSTAKDERGRKTVIDLLGQSNRVYPVGRLD 105

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
           +DSEGL++LTN+G L  R+T P     K Y V+VEG  +  +L+ L  GV L DG + P 
Sbjct: 106 KDSEGLMLLTNDGELAQRITHPRYGVHKQYMVEVEGYFSDRSLQDLLQGVELEDGFSKPL 165

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
            A+++                +S   S L IT+ EGR RQVRR  A +G+   RL R A+
Sbjct: 166 DAKIIS---------------RSRDKSKLLITMGEGRKRQVRRTLAALGYKVKRLTRVAL 210

Query: 200 GDYSLDNLANGEWREVTD 217
           G  SL NL  GE+RE++D
Sbjct: 211 GPLSLGNLKPGEYRELSD 228


>UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=Q65HX7_BACLD
          Length = 244

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 74/211 (35%), Positives = 105/211 (49%), Gaps = 17/211 (8%)

Query: 10  TMQKTSFRNHQVKRFSSQRST--RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI 67
           T+   + R   VK  SS R      + E++     L  KP  V+    D+ GRK + +F 
Sbjct: 29  TVNGKTVRELGVKVSSSDRIEVNGVQLESEEPVYFLLYKPRGVISAVKDDKGRKVVTDFF 88

Query: 68  PV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL 125
               + +Y  GRLD D+ GLL+LTN+G    +L  P     K Y  +++GIP ++ L+ L
Sbjct: 89  TEVEERIYPIGRLDYDTSGLLLLTNDGDFANKLMHPKYEINKTYVAKLKGIPLKENLKKL 148

Query: 126 RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTA 185
             GV L DG T PA  +L+                K   TS ++IT++EGRNRQVRRM  
Sbjct: 149 ERGVRLEDGKTAPAKVKLLSLD-------------KKKQTSIVQITIHEGRNRQVRRMFE 195

Query: 186 HVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            +G   L+L R      +L  L  GE RE+T
Sbjct: 196 AIGHEVLKLKREEYAFLNLAGLKTGEKRELT 226


>UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=A3YG85_9GAMM
          Length = 242

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 98/174 (56%), Positives = 123/174 (70%), Gaps = 1/174 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
             +I+FNKP+ VL QFT +  + TL  FI     Y AGRLD DSEGLL+LT++GALQ  +
Sbjct: 2   PSIIVFNKPFQVLSQFTTDEEKATLSSFIDKANFYPAGRLDYDSEGLLLLTDHGALQHLI 61

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P  +  K Y VQVEG  T++A+E LR GV L DG T PA A++  +    WPR+PPIR
Sbjct: 62  ASPQHKMPKTYLVQVEGELTKEAVEQLRVGVELKDGLTKPAEAKIASD-FEPWPRHPPIR 120

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           ERK+IPTSWL++T+ EG+NRQVRRMTA VGFPTLRLIR  +G YSL ++  G W
Sbjct: 121 ERKNIPTSWLELTITEGKNRQVRRMTAAVGFPTLRLIRTQIGPYSLTDIELGHW 174


>UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KIR7_9FIRM
          Length = 250

 Score =  213 bits (542), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 67/183 (36%), Positives = 94/183 (51%), Gaps = 11/183 (6%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGAL 94
           +    +L NKP   L    D+ GR+T+ + +P   + VY  GRLD ++EGLL++TN+GAL
Sbjct: 63  EQHVYLLLNKPKGYLSTAKDDRGRRTVLDLLPEVRERVYPVGRLDNNTEGLLLITNDGAL 122

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              L  P     K Y+  V G  T++ L+ LR+G+ L DG T PA   L+ E        
Sbjct: 123 MNGLLHPRFEVEKTYHAGVTGKLTEEKLQMLRDGLLLEDGMTAPAKVSLLPEREPGERVR 182

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
              R           IT++EGRNRQVRRM A VG     L R      +L  +A G+ R 
Sbjct: 183 GLTRAA---------ITIHEGRNRQVRRMFAAVGCDVKSLKRVRFAGLTLKGVARGQHRA 233

Query: 215 VTD 217
           +T+
Sbjct: 234 LTE 236


>UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B n=200 Tax=Bacteria
           RepID=RLUB_BACSU
          Length = 244

 Score =  211 bits (538), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 67/199 (33%), Positives = 97/199 (48%), Gaps = 15/199 (7%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGR 77
           +V           K E +     L  KP  V+    D+ GRK + +F     Q +Y  GR
Sbjct: 41  KVTGSDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGR 100

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD D+ GLL+LTN+G    +L  P     K Y  +V+GIP ++ L  L  G+ L +G T 
Sbjct: 101 LDYDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA 160

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           PA A+L+                K   TS +++T++EGRNRQVRRM   +G   ++L R 
Sbjct: 161 PAKAKLLSLD-------------KKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKRE 207

Query: 198 AMGDYSLDNLANGEWREVT 216
                +L  L  G+ RE+T
Sbjct: 208 EYAFLNLRGLHTGDARELT 226


>UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6VXU0_DYAFD
          Length = 555

 Score =  211 bits (537), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 63/218 (28%), Positives = 101/218 (46%), Gaps = 23/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + +     ++V+     +  ++    +    IL NKP D +    D   RKT
Sbjct: 348 QISVNGKIVTEM---GYKVRPTDVVKYGKKALNPEKMVYILINKPKDYITTTDDPEERKT 404

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + I     + VY  GRLDR++ GLL+LTN+G L  +LT P     KIY  +++   T 
Sbjct: 405 VLDIIAGACSERVYPVGRLDRNTTGLLLLTNDGELAEKLTHPSSGIKKIYQAELDKPITT 464

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +  E L+ GV L DG   P    LV   A +                 + + ++ GRNR 
Sbjct: 465 EDFEQLKAGVELEDGFIRPDEVGLVTPDAQV-----------------VGLEIHSGRNRI 507

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRRM  H+G+   +L R      +  +L  G+WR +T+
Sbjct: 508 VRRMFEHLGYEVQKLDRTVFAGLNKKDLPRGKWRFLTE 545


>UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q24V73_DESHY
          Length = 257

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 70/179 (39%), Positives = 88/179 (49%), Gaps = 16/179 (8%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
             L +KP   +   TD  GRKT+ E +P   + VY  GRLD D+ GLL+LTN+G L  RL
Sbjct: 78  YYLLHKPTGYITSVTDPQGRKTVMELMPKIPRRVYPVGRLDYDTSGLLLLTNDGDLAHRL 137

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P     K Y V+V     + AL+ L  GV L DG T PA    V              
Sbjct: 138 MHPSYGVEKTYRVEVGEKIPEQALKRLEKGVLLEDGKTAPARIREVSPKGRGSLP----- 192

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
                     +IT++EGRNRQVRRM   VGFP   L R   G   LD +LA G +R ++
Sbjct: 193 --------TYEITIHEGRNRQVRRMFKAVGFPLSTLKRLRFGPLELDPSLAPGAFRTLS 243


>UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1ZYI5_OPITP
          Length = 188

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 89/176 (50%), Positives = 113/176 (64%), Gaps = 2/176 (1%)

Query: 43  LFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
             +KPY VL QFT E G +  TL EF     VY  GRLD DSEGLL+L++   L  RL  
Sbjct: 4   ALHKPYGVLSQFTPEPGSRWRTLAEFGLPPAVYPLGRLDADSEGLLLLSDEPGLNTRLLN 63

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P +   + Y+VQVE +PT  AL  L+ GV + D  T P  A  +D    L PR+PPIR R
Sbjct: 64  PDQAHRREYWVQVERVPTDAALAQLQRGVKIGDYATRPCAARRLDPAPTLPPRDPPIRAR 123

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           K++P  WL + L EG+NRQVRRMTA +G PTLRL+R  +GD++L  LA G+WRE+T
Sbjct: 124 KNVPDCWLALELIEGKNRQVRRMTAAIGHPTLRLVRVRIGDFALGKLAVGQWRELT 179


>UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter RepID=A3M7K0_ACIBT
          Length = 262

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 95/178 (53%), Positives = 122/178 (68%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++ NKPYDVL QF  +    T+ +F+    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVILNKPYDVLSQFRKDEAHMTVSDFVDDPTLRIAGRLDMDSEGLVFLTDHGGLNQFIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T++ALE LR GV LNDG TLPA A  V EP WLW R+PP+R 
Sbjct: 62  NPANKKYKTYLVQVDGDVTEEALEQLRKGVELNDGMTLPAKAIKVSEPEWLWDRDPPVRY 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD--NLANGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMT+ VGFPTLRLIR  +G   L    L  GE +E+
Sbjct: 122 RASIPTSWIEISICEGRNRQVRRMTSAVGFPTLRLIRTKIGTIDLVQLGLQPGETKEI 179


>UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A4SY81_POLSQ
          Length = 587

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 61/192 (31%), Positives = 91/192 (47%), Gaps = 19/192 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEG 84
           +   RK + +P RVI+++KP   +   +D  GR T+ + +P        A GRLD ++EG
Sbjct: 247 KPVHRKIQTKPPRVIMYHKPAGEIVSQSDPEGRPTVFDRLPKPRQGRWIAVGRLDFNTEG 306

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ T +G L  RL  P     + Y V++ G  +Q+    L++G+TL+DG        + 
Sbjct: 307 LLLFTTSGELANRLMHPRYGVEREYAVRILGDLSQENTALLKSGITLDDGQAKFLRLAM- 365

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W  + L EGRNR+VRRM   VG    RLIR   G + L
Sbjct: 366 --------------GGGEGANRWYHVALSEGRNREVRRMFEAVGHTVSRLIRTRYGIFLL 411

Query: 205 -DNLANGEWREV 215
              L  G+W E+
Sbjct: 412 PPRLRRGKWEEI 423


>UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=B2T6J8_BURPP
          Length = 189

 Score =  209 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 86/180 (47%), Positives = 116/180 (64%), Gaps = 4/180 (2%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
            ++  NKP+  + QF+    R +L +++ V  VY AGRLD DSEGLL+LT++GALQAR+ 
Sbjct: 2   HLLALNKPFGTICQFSPHETRASLADWVKVPDVYPAGRLDSDSEGLLLLTDDGALQARIA 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           +P  +  K Y+ QVEG      L+ L  GV L D  T P  AE V+    LW R PPIR 
Sbjct: 62  EPRHKLVKRYWAQVEGAVDAATLKKLARGVDLGDYVTRPCRAEYVEPTDALWTRTPPIRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY---SLDNLANGEWREVT 216
           R +IPT+W+++++ EG+NRQVRRMTA VGFPTLRL+R  +G     SL  L  GE  E++
Sbjct: 122 RAAIPTTWIELSITEGKNRQVRRMTAAVGFPTLRLVRVGIGALDIFSLG-LQPGESVELS 180


>UniRef50_P0AA45 Ribosomal small subunit pseudouridine synthase A n=156
           Tax=Gammaproteobacteria RepID=RSUA_ECO57
          Length = 231

 Score =  209 bits (533), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 63/225 (28%), Positives = 98/225 (43%), Gaps = 29/225 (12%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFS-SQRSTRRKPENQP--TRVILFNKPYDVLPQFTDEA 58
           R+   +  T+     RN   K       +    P  Q    R  + NKP   +    D  
Sbjct: 20  REIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGPRYFMLNKPQGYVCSTDDP- 78

Query: 59  GRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
              T+  F+       ++AAGRLD D+ GL+++T++G    R+T P     K Y V +E 
Sbjct: 79  DHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLES 138

Query: 116 IPTQDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
               D  E    GV L++    T PA  E++                     + +++T+ 
Sbjct: 139 PVADDTAEQFAKGVQLHNEKDLTKPAVLEVITP-------------------TQVRLTIS 179

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           EGR  QV+RM A VG   + L R  +G  +LD +LA GE+R +T+
Sbjct: 180 EGRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTE 224


>UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wolfei subsp. wolfei
           str. Goettingen RepID=Q0AX41_SYNWW
          Length = 239

 Score =  209 bits (532), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 57/213 (26%), Positives = 96/213 (45%), Gaps = 20/213 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           +++ T+ + +F    +K         +  E      +L +KP   +    D  GR  + +
Sbjct: 29  VNDKTITELAF---TLKPGDRVEFAGKIIEQTDKIYLLLHKPAGYISSLADPQGRPRVID 85

Query: 66  FIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +      V+  GRLD D+EGLL+L+N+G     +T P     K Y   V+G+   D + 
Sbjct: 86  LLSAVNTRVFPVGRLDYDTEGLLLLSNDGEFSNLMTHPRYLIPKKYEAWVQGLVKPDTIR 145

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            L  GV L DG T PA   L+                     S L++ ++EG+ RQ++RM
Sbjct: 146 QLEQGVALEDGITAPARVRLLSSK---------------KGQSLLELEIHEGKKRQIKRM 190

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VG    +L R A+   +L+ +  G++R +T
Sbjct: 191 CLAVGHRVTKLKRTALAFLTLEGVPRGQFRFLT 223


>UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales RepID=A2S4Y2_BURM9
          Length = 235

 Score =  208 bits (531), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 98/211 (46%), Positives = 132/211 (62%), Gaps = 8/211 (3%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI 67
            + S    ++  F+ +R  RR      E  P R+I  NKP+  + QF+    R +L +++
Sbjct: 13  TRRSVLCIKIPPFAIERGPRRAAPLPREPCPMRLIALNKPFGTICQFSAHETRASLGDWV 72

Query: 68  PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRN 127
              GVY AGRLD DSEGLL+LT++GALQA++ +P  +  K Y+ QVEG P   AL AL  
Sbjct: 73  KTPGVYPAGRLDADSEGLLLLTDDGALQAKIAEPRHKLVKRYWAQVEGAPDAAALAALER 132

Query: 128 GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
           GV L D  + P  A  +  P  LWPRNPPIR R +IPT+W+++ + EG+NRQVRRMTA V
Sbjct: 133 GVDLGDYVSRPCRARFITPPGALWPRNPPIRHRAAIPTAWIELEIAEGKNRQVRRMTAAV 192

Query: 188 GFPTLRLIRYAMGDY---SLDNLANGEWREV 215
           GFPTLRL+R  +G     +L  LA GE RE+
Sbjct: 193 GFPTLRLVRVGIGALDVFALG-LAPGETREL 222


>UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria RepID=A0Z1Z6_9GAMM
          Length = 208

 Score =  208 bits (531), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 88/175 (50%), Positives = 115/175 (65%), Gaps = 4/175 (2%)

Query: 41  VILFNKPYDVLPQFTD---EAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           +IL NKP+ VL QF+D   +  R TL   +       AGRLD DSEGL +LT++G LQ +
Sbjct: 26  IILLNKPFRVLSQFSDRDNDPPRLTLANLLSAPEFRVAGRLDYDSEGLTLLTDDGKLQQQ 85

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPI 157
           +  P  +  K Y+VQVEG P Q A+E L +GV LNDG T PA    +D P  LW R+P +
Sbjct: 86  IANPKFKVWKTYWVQVEGAPKQQAIEQLTSGVVLNDGLTKPAKVRAID-PPDLWERSPSV 144

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           R R  IP +WL+I++ EGRNRQ+RRMTA V  PTLRL+R A+GD+ + NL  GE+
Sbjct: 145 RFRAHIPDAWLEISIQEGRNRQIRRMTAAVNLPTLRLVRIAIGDWEIGNLQPGEY 199


>UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C0FY58_9FIRM
          Length = 261

 Score =  208 bits (531), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 66/222 (29%), Positives = 105/222 (47%), Gaps = 26/222 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGR 60
           +Q  ++   + K      +V   + Q S + +P         LF KP   +    D    
Sbjct: 49  KQITVNGEIVTKPET---KVAPENDQISYKGEPVTYCEYEYYLFYKPAGCVTATED-QLH 104

Query: 61  KTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           KT+ +++       ++  GRLD D+EGLL++TN+GAL   L  P K   K YY  ++G+ 
Sbjct: 105 KTVMDYLTDTVRSDLFPVGRLDIDTEGLLLITNDGALAHDLLSPAKHVEKTYYAVIDGVV 164

Query: 118 TQDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           T+  + +  NGV +  +  T P    ++                KS P S +++T+ EGR
Sbjct: 165 TEKDVNSFENGVDIGEEKLTKPGKLRIL----------------KSEPESEIELTITEGR 208

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
             QV+RM   VG   L L R +MG   L D+L  GE+R +T+
Sbjct: 209 FHQVKRMFEAVGKKVLYLKRISMGPLQLTDDLKPGEYRPLTE 250


>UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine synthase B n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3D27
          Length = 271

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 68/208 (32%), Positives = 101/208 (48%), Gaps = 18/208 (8%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--V 69
           K +    ++   + Q +   +P   +       NKP   L    D AGR    + +P   
Sbjct: 34  KVTELGLKIDPSAHQIAVDDQPVRAEKLVYWAVNKPVGHLCTNHDPAGRPRAVDLLPHVE 93

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           Q VY  GRLD  S+GLL++TN+G L   LT P     K+Y+V V G PT D L+ L +GV
Sbjct: 94  QRVYTVGRLDEGSDGLLLMTNDGDLAQGLTHPRYGVPKMYFVLVAGRPTDDDLQKLMDGV 153

Query: 130 TLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
            L+DG      A+ +               +     +W+++ L EG+NR++RRM A  G 
Sbjct: 154 WLSDGKVRAKSAKRI---------------KAQGNGTWVRVVLTEGKNREIRRMLAKFGH 198

Query: 190 PTLRLIRYAMGDYSLDNLANGEWREVTD 217
             +RL R A+G   LD L  G+ R ++D
Sbjct: 199 KVMRLKRVAIGPVKLDKLPKGKARRISD 226


>UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YJH7_THEYD
          Length = 237

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 68/192 (35%), Positives = 99/192 (51%), Gaps = 17/192 (8%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEG 84
           +   +   + +P     F KP  V+    D  GR T+++FI      +Y  GRLD DSEG
Sbjct: 50  KVDGKLLIKPEPKVYYAFYKPRKVITALLDPQGRPTIRDFIKGIKFRIYPVGRLDFDSEG 109

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LTN+G L  ++  P  +  K Y V+V+GI   + +E LR G+ +     +P    LV
Sbjct: 110 LLLLTNDGELAYKVMHPSSQIEKTYMVKVDGIVEPETIEKLRKGIKIEGKLAVPVSVHLV 169

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                          +K    SW+KITL+EGR RQ+R+M   VG P +RLIR A+    L
Sbjct: 170 ---------------KKLKANSWIKITLHEGRKRQIRKMLERVGHPVIRLIRIAIDGVKL 214

Query: 205 DNLANGEWREVT 216
            +L  G+ R +T
Sbjct: 215 GDLKPGQLRPLT 226


>UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q6FCZ3_ACIAD
          Length = 264

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 99/178 (55%), Positives = 125/178 (70%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++FNKPYDVL QF +++   T+  FI    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVVFNKPYDVLSQFREDSAHLTVSSFIADPELRIAGRLDLDSEGLMFLTDHGGLNQYIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T+DALE LR GV L DG TLPA A  V+EP WLW RNPP+R 
Sbjct: 62  HPSNKKYKTYLVQVDGDITEDALEKLRKGVELADGLTLPAQATKVEEPEWLWERNPPVRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD--NLANGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMTA VGFPTLRLIR  +G  +L    L  GE +E+
Sbjct: 122 RASIPTSWVEISICEGRNRQVRRMTATVGFPTLRLIRTQIGSINLVKLGLQPGEQKEI 179


>UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7I2_9ACTN
          Length = 285

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 59/186 (31%), Positives = 90/186 (48%), Gaps = 8/186 (4%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQ 95
              +L NKP  VL   +D  G   +   +P     G++  GRLD D+ G+L+ T NG + 
Sbjct: 85  HVYLLLNKPSQVLTTMSDPFGFPCVASLVPCDDYPGLFPVGRLDSDTTGVLLFTTNGNMG 144

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV--DEPAWLWPR 153
            RL  P     K Y   +EG  T   ++ L  G+ L DG T P     +  DEP     +
Sbjct: 145 NRLLHPSHHVWKTYVALIEGKLTSSQMQKLSQGIMLEDGMTSPCFIRTITQDEPCTHLDK 204

Query: 154 NPPIRE--RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANG 210
           N  + +  R +  +S  ++ ++EGRN QV+RM   +G P ++L R+  G   L+  +  G
Sbjct: 205 NHSLFDDMRLNAASSLCELKIHEGRNHQVKRMLQEIGHPVIKLHRFQFGPLCLNAQIPLG 264

Query: 211 EWREVT 216
            WR  T
Sbjct: 265 SWRMCT 270


>UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia JCVIHMP010
           RepID=D1Y0J0_9BACT
          Length = 555

 Score =  207 bits (527), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 51/218 (23%), Positives = 99/218 (45%), Gaps = 22/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + +      ++ R    +   +    +    +L NKP D +    D   RKT
Sbjct: 345 QVTVNGEVINEL---GTKILRTDEVKFQDKLVSLEKKVYVLLNKPKDYVTTSDDPQQRKT 401

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +     + +Y  GRLDR++ G+L+ TN+G L ++LT P     K+Y+V ++   T 
Sbjct: 402 VMDLVKDACPERIYPVGRLDRNTTGVLLFTNDGDLASKLTHPKFLKKKVYHVFLDKPITA 461

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+ + +G+ L DG       E  +                    + + I ++ G+NR 
Sbjct: 462 NELQKISDGIELEDGEIKADAIEYANPEDQ----------------AQVGIEIHSGKNRI 505

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRR+   +G+  ++L R      +  N+  G+WR +T+
Sbjct: 506 VRRIFESLGYRVVKLDRVMFAGLTKKNVRRGDWRFLTE 543


>UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L6G3_MAGSM
          Length = 332

 Score =  206 bits (526), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 74/217 (34%), Positives = 103/217 (47%), Gaps = 22/217 (10%)

Query: 6   ISENTMQKTSFRNHQVKRF--SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
           I+   + +   +  +  R     Q  T   P+      I+ +KP  ++   +D  GR+T+
Sbjct: 98  INGEVVTELGVKVAKRDRVAVDGQLVT---PQRSRDTAIILHKPKSIICTRSDPQGRRTI 154

Query: 64  KEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + I   G   +   GRLD +SEGL++LT++G L   L  P +   ++Y V+  GI    
Sbjct: 155 FDLIENHGSSRLITVGRLDINSEGLIILTSDGQLAHGLMHPSREVPRVYRVKTHGILLAS 214

Query: 121 ALEALRN-GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            LE +R  GV L DGPT P    L              R R+    SW  ITL EGRNR+
Sbjct: 215 QLEQIRTVGVRLEDGPTGPLEIVL-------------DRGREQGNNSWYTITLREGRNRE 261

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRR+  H G    RL+R   G  SL NL  G WR VT
Sbjct: 262 VRRIFDHFGLQVARLLRVGYGGISLGNLEPGAWRPVT 298


>UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroidetes
           RepID=D2QMI8_9SPHI
          Length = 638

 Score =  206 bits (525), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 59/205 (28%), Positives = 96/205 (46%), Gaps = 20/205 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG-- 71
            +   ++VK   + +   +    +    +L NKP D +    D   RKT+ E +   G  
Sbjct: 438 VTEMGYKVKEGDTVKYGTKVLNPERFVYVLLNKPKDYITTTEDPEERKTVMELVADAGKF 497

Query: 72  -VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            +Y  GRLDR++ GLL++TN+G L  +LT P     KIY V+++   T +  EA++ G+ 
Sbjct: 498 RMYPVGRLDRNTTGLLLITNDGELADKLTHPSNNIRKIYQVELDKPITDEHFEAIKKGIE 557

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L DGP  P    +V   A++                 + I ++ GRNR VRR+    G+ 
Sbjct: 558 LEDGPIKPDAISIVTPDAYV-----------------VGIEIHSGRNRIVRRIFESFGYE 600

Query: 191 TLRLIRYAMGDYSLDNLANGEWREV 215
             +L R      +   L  G+WR +
Sbjct: 601 VTKLDRTTYAGLTKKELPRGKWRFL 625


>UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C7M7R0_CAPOD
          Length = 387

 Score =  206 bits (524), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 58/214 (27%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   M       ++VK     R   +   ++    IL NKP   +    DE GRKT+ +
Sbjct: 182 VNGEVMTTL---GYRVKPTDEVRFDGKLLSSEKKEYILLNKPKGFITTTNDEKGRKTVMD 238

Query: 66  FIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
            +       +   GRLDR + GLL+LTN+G L  +LT P     KIY+V ++        
Sbjct: 239 LVANATNVRILPVGRLDRATTGLLLLTNDGELTKKLTHPTHGVRKIYHVILDRKLDYKDF 298

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
             +++G+ L DG         V++                 P + + I ++ GRNR VRR
Sbjct: 299 MKVQDGLELEDGLIEVDEISYVNDK----------------PKNEIGIKIHSGRNRIVRR 342

Query: 183 MTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +  H+G+   +L R      +  +L  G WR +T
Sbjct: 343 IFEHLGYQVEKLDRVVFAGLTKKDLPRGHWRRLT 376


>UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZQL4_9PLAN
          Length = 517

 Score =  205 bits (523), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 69/198 (34%), Positives = 97/198 (48%), Gaps = 21/198 (10%)

Query: 19  HQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAGR 77
           HQ      QR    K         + NKP  VL    D AGR  + + +P    ++  GR
Sbjct: 61  HQEILVDGQRLKFGK-----RVYYMLNKPPGVLSTNFDPAGRTRVIDMVPQDVRLFTIGR 115

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LDR SEGL+V+TN+G L  RL  P     K Y V+V G P  DA+  +R GV L +G   
Sbjct: 116 LDRASEGLIVVTNDGELANRLAHPRYEIEKTYRVEVAGHPEPDAITFVRRGVHLAEGFVQ 175

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           P                  + +RK+  ++ L++ L EG+NR++RR+ A +G   LRL R 
Sbjct: 176 PVSV---------------VMKRKNKQSTTLEVILDEGKNREIRRLMAKIGHKVLRLKRI 220

Query: 198 AMGDYSLDNLANGEWREV 215
           AMG   L  +  G +RE+
Sbjct: 221 AMGPLRLGEMPEGAFREL 238


>UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZD4_9DELT
          Length = 240

 Score =  205 bits (523), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 61/200 (30%), Positives = 99/200 (49%), Gaps = 19/200 (9%)

Query: 21  VKRFSSQRSTRRKPENQPTR--VILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAG 76
           +     Q +   +P   P+R   +L NKP   +    D  GR  +   I  P   ++  G
Sbjct: 43  IDPERQQVTFDGQPVLPPSRKLTVLLNKPAGYVTTMADPQGRPIVTSLINEPGLRLFPVG 102

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLD D+EG L+LTN+G L   +  P ++  + Y+  V+G P ++AL+ LR G+ L    T
Sbjct: 103 RLDLDTEGALLLTNDGELAQNILHPSRQINRTYHATVKGRPNREALQQLRRGIMLEGRRT 162

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
            PA    +               R++  ++ L++ ++EGR RQVR+M A +  P L+L R
Sbjct: 163 WPARIREL---------------RRNQESTTLEVIIHEGRKRQVRKMFAAINHPVLQLKR 207

Query: 197 YAMGDYSLDNLANGEWREVT 216
            A G   L +L  G +R ++
Sbjct: 208 VAYGGLRLGSLPTGRYRRLS 227


>UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9GX03_SORC5
          Length = 399

 Score =  205 bits (522), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 62/213 (29%), Positives = 101/213 (47%), Gaps = 19/213 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   + +   +  + K         ++  ++    +  +KP +V+    D  GR T+ +
Sbjct: 31  VNGRVVTELGLKADRQK--DRIEVDGKRLVSEAPVYVALHKPRNVVSTLRDPEGRPTVAD 88

Query: 66  FIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +      +Y  GRLD  + G+L++TN+G     L  P     K Y ++V+G+ + D L 
Sbjct: 89  HVRGTGARLYPVGRLDFATSGILLMTNDGDFANALLHPRGGVPKTYVLKVQGVMSDDDLT 148

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
             R G+ L DG TLPA A L+               R     +WL++TL EGRN+Q+RRM
Sbjct: 149 PWREGIRLEDGVTLPAEARLL---------------RHEGDKTWLEVTLREGRNQQIRRM 193

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
               G+P +RL R      S + L  GEWR +T
Sbjct: 194 GEATGWPVMRLARTTFAGVSSEGLRPGEWRALT 226


>UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RK28_FIBSS
          Length = 243

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 62/217 (28%), Positives = 99/217 (45%), Gaps = 21/217 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRK----PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           ++  T+       HQV     Q +   K    P N+ T+VI+F+KP   +    D  GR+
Sbjct: 29  VNGETISDL---GHQVDETKDQVTVDGKLLKLPTNKKTKVIMFHKPAGCVCTKDDPQGRR 85

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ +++P         GRLD  S GLL+ T++G L  RLT P     + YYV      ++
Sbjct: 86  TVYDYLPPGYHNFKYVGRLDLQSRGLLLFTDDGELLYRLTHPSFEVPRSYYVWTTRPLSE 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            A + L +GV + D     A  E+                   +   + ++ L EG+NR+
Sbjct: 146 SAAQRLVDGVDIRDPEDPDAQEEI------------AFATDVYLENGFAELVLIEGKNRE 193

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +RRM   +G+    L R +     L +L  GE+RE+T
Sbjct: 194 IRRMMRAIGYEIRDLKRVSYCQIQLGDLPAGEFRELT 230


>UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gingivalis ATCC 33277
           RepID=B2RK43_PORG3
          Length = 439

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 22/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +      ++ R        ++ E +    +L NKP + +    D   R T
Sbjct: 229 EITVNGEVVTEL---GRRITRQDEVIYKDKRVEIESKVYVLLNKPKNCVTTSDDPECRTT 285

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +     + +Y  GRLDR++ G+L++TN+G L ++LT P  +  KIY+V +    + 
Sbjct: 286 VMDIVRYACPERIYPVGRLDRNTTGVLLITNDGDLASKLTHPSFKKKKIYHVWLNKDVSI 345

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + ++ + +GV L+DG         V E                   S + I ++ GRNR 
Sbjct: 346 EDMQKIADGVELDDGEIHADAISYVKEDDL----------------SQVGIEIHSGRNRI 389

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRR+  H+G+  ++L R      +  NL  G+WR + +
Sbjct: 390 VRRLFEHLGYRVVKLDRVYFAGLTKKNLPRGKWRYLNE 427


>UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0N6F1_9FIRM
          Length = 241

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 15/204 (7%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQG 71
            +    +VK+        +    +     +F KP   +    DE  R  + ++     + 
Sbjct: 35  VTELGTKVKQGDLITVEGKPLVGENKVYYVFYKPKGCVCTLDDEFDRPIITDYFTEVKER 94

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +Y  GRLD D+ GL++++N+G     +  P     KIY V ++G+ T   L  L  GV L
Sbjct: 95  IYPVGRLDFDTTGLIIMSNDGEFANMIMHPRSHLEKIYEVSIKGLITGPTLNKLEKGVYL 154

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
               TLP   ++VD+                  T+ LKI L EG+NRQV++M   VG P 
Sbjct: 155 EGVKTLPCKIKVVDKDT-------------EHKTTMLKIKLVEGKNRQVKKMFESVGHPV 201

Query: 192 LRLIRYAMGDYSLDNLANGEWREV 215
            RL R ++G  +L  L  G +R +
Sbjct: 202 KRLHRVSIGGINLKGLTPGRYRIL 225


>UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=B2A4P2_NATTJ
          Length = 238

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 19/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   + +               E +    I+ NKP D +    D  GRKT
Sbjct: 26  RVTVNGQVITRLGTKINPDTDTVKVDGEPITQE-ESNVYIMLNKPKDYITSKDDPQGRKT 84

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + I   + VY  GRLD DS GL++LTN+G L  RL  P     K Y V+V+ +P QD 
Sbjct: 85  VMDLIQVKERVYPVGRLDYDSRGLVLLTNDGELANRLMHPKYNIPKTYMVKVDKLPLQDK 144

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L+ L NG+ L +G       E++D                    + LKI L EGR RQ+R
Sbjct: 145 LDNLVNGIYLEEGLCKADHVEILD-----------------TKNNILKIILSEGRKRQIR 187

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RM A +G     L R ++G  +L +L+ G +R++T
Sbjct: 188 RMLASLGIEVKDLKRDSLGTLTLKDLSEGNYRKLT 222


>UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3JBA6_9PORP
          Length = 459

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 54/215 (25%), Positives = 94/215 (43%), Gaps = 22/215 (10%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   + +       V R        +    +    +L NKP + +   +D   R T  +
Sbjct: 252 VNGEIVTQL---GKHVTREDFISVDGKPVSIEKKIYVLLNKPRNCVTTSSDPEKRLTAID 308

Query: 66  FIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
            +     + +Y  GRLDR++ GLL+LTN+G L A+L  P     KIY V ++   + + +
Sbjct: 309 LVRNACNERIYPVGRLDRNTTGLLLLTNDGDLAAKLMHPKYEKKKIYQVTLDKPVSVEHM 368

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
           + + +G+ L DG         VDE                   + + I ++ GRNR VRR
Sbjct: 369 QQIASGIELEDGEIHADAISYVDENNL----------------AIVGIEIHSGRNRIVRR 412

Query: 183 MTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +  H+G+   +L R      +  +L  G WR +T+
Sbjct: 413 IFKHLGYRVYKLDRVYFAGLTKKDLPRGRWRYLTE 447


>UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A4J9G8_DESRM
          Length = 249

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 70/222 (31%), Positives = 107/222 (48%), Gaps = 25/222 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q +++              +            E +    ++ NKP DVL    D +  K
Sbjct: 31  KQVMVNGELAMDPGLHIFPQR--DHIEVQGEVIEYREYIYLMLNKPQDVLSATEDASD-K 87

Query: 62  TLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            + + +         +  GRLD+D+EGLL+LTNNG L  +L  P K   K YY  V+G+ 
Sbjct: 88  VVIDLLDPTYHSFNPFPVGRLDKDTEGLLLLTNNGKLAHQLLSPKKHVPKTYYALVQGLV 147

Query: 118 TQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           T++ + A   GV L+DG  TLP   +++                +S P S +++T+YEG+
Sbjct: 148 TEEDVAAFARGVELDDGYRTLPGQLKII----------------RSAPQSEIELTIYEGK 191

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
             QV+RM   VG   + L R +MG   LD NL  GE+RE+TD
Sbjct: 192 YHQVKRMFEAVGKRVIYLKRLSMGPLVLDNNLKPGEYRELTD 233


>UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter heparinus DSM 2366
           RepID=C6Y027_PEDHD
          Length = 472

 Score =  204 bits (520), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 55/208 (26%), Positives = 95/208 (45%), Gaps = 20/208 (9%)

Query: 14  TSFRNHQVKRFSSQ-RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI---PV 69
            S   H++     Q R      + +    +L NKP D +    D   R+T+ + +     
Sbjct: 270 VSELGHKIDPVKDQVRYNGELLKREKKIYVLLNKPKDYITTTDDPQERRTVMQLVEKASR 329

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           + +Y  GRLDR++ GLL++TN+G L  +L+ P     KIY+V++    +Q  L  ++ G+
Sbjct: 330 ERIYPVGRLDRNTTGLLLMTNDGDLADKLSHPKNGITKIYHVELSRSLSQGDLNKIQFGL 389

Query: 130 TLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
            L DG   P     V                       + I ++ G+NR VRR+  H+G+
Sbjct: 390 ELEDGIIKPDSVSYVT----------------GGSKREVGIQIHSGKNRIVRRIFEHLGY 433

Query: 190 PTLRLIRYAMGDYSLDNLANGEWREVTD 217
             ++L R   G+ +  +L  G WR + +
Sbjct: 434 DVVKLDRVVYGNLTKKDLPRGRWRYLEE 461


>UniRef50_Q12AB3 Pseudouridine synthase n=8 Tax=Proteobacteria RepID=Q12AB3_POLSJ
          Length = 544

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 59/194 (30%), Positives = 88/194 (45%), Gaps = 19/194 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEG 84
           +  R + +  P RVI ++KP   +    D   R T+   +P        + GRLD ++EG
Sbjct: 147 KPIRVRIDPPPPRVIAYHKPSGEVVTHDDPQNRPTVFRRLPKLFQGKWQSVGRLDLNTEG 206

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LT++G L  +L  P     + Y V+V G  + +  + L  GVTL+DG    +  E  
Sbjct: 207 LLLLTSSGELANKLMHPRFGLEREYAVRVLGALSNEEKKRLLEGVTLDDGVAQFSSIE-- 264

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W ++T+ EGRNR+VRRM   VG    RLIR   G   L
Sbjct: 265 -------------AGGGEGANCWYRVTISEGRNREVRRMFEAVGHAVSRLIRIRYGAMLL 311

Query: 205 -DNLANGEWREVTD 217
              L  G + E+ +
Sbjct: 312 PRGLKRGAFVELDE 325


>UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2S0_9FIRM
          Length = 290

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 64/183 (34%), Positives = 96/183 (52%), Gaps = 17/183 (9%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGA 93
           N+    IL +KP   L    D+ GR+T+ + +P     +Y  GRLD D+EGLL++TN+GA
Sbjct: 60  NERRFYILLHKPRGCLSTAYDDRGRRTVLDLLPHFPARLYPVGRLDADTEGLLIITNDGA 119

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           +   L  P     K+Y  +V G  T+D L ALRNG+ L+DG T PA   ++         
Sbjct: 120 MTQGLLHPRFEIDKVYRAEVTGNVTEDGLTALRNGILLDDGRTAPARLRVL--------- 170

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                  +    + ++  ++EGR RQVRRM A +G    RL R      +LD ++ G +R
Sbjct: 171 ------HREGERTVVETIIHEGRKRQVRRMFAAIGCRVQRLCRVRFAMLTLDGVSCGSFR 224

Query: 214 EVT 216
            +T
Sbjct: 225 HLT 227


>UniRef50_A1WE21 Pseudouridine synthase n=1 Tax=Verminephrobacter eiseniae EF01-2
           RepID=A1WE21_VEREI
          Length = 520

 Score =  203 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 66/227 (29%), Positives = 94/227 (41%), Gaps = 25/227 (11%)

Query: 1   MRQFIISENT-MQKTSFRNHQVKRFSSQRSTRRKPENQ-----PTRVILFNKPYDVLPQF 54
           M Q I+     +        Q  +F  Q     KP        P RVI ++KP   +   
Sbjct: 188 MEQLILEGRISVNNEPAHIGQRIQFGDQVKVNGKPIRYRIDPPPARVIAYHKPVGEVVSH 247

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D   R T+   +P        + GRLD ++EGLL+LT++G L  +L  P     + Y V
Sbjct: 248 DDPHNRPTVFRRLPRLVQGKWQSVGRLDLNTEGLLLLTSSGELANQLMHPRFGLEREYAV 307

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +V G  + +  + L +GV L+DG       E                        W ++T
Sbjct: 308 RVLGALSNEEKQKLLDGVRLDDGIASFGTIE---------------DGGGEGANCWYRVT 352

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
           + EGRNR+VRRM   VG    RLIR   G   L   L  G W E+ +
Sbjct: 353 IAEGRNREVRRMLEAVGHAVSRLIRIRYGAMVLPRGLKRGTWLELDE 399


>UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepID=B9E1X9_CLOK1
          Length = 245

 Score =  203 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 60/179 (33%), Positives = 95/179 (53%), Gaps = 16/179 (8%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARL 98
             IL NKP   +    D+ GRKTL + + V + VY  GRLD ++ G ++LTN+G +   +
Sbjct: 70  VYILLNKPRGYISSVKDDRGRKTLLDIVKVNERVYPIGRLDYNTSGAIILTNDGEVYNNI 129

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             PG    KIY   ++GIP+ + ++   NG+ +    T  A  + +              
Sbjct: 130 AHPGSNKSKIYIAAIKGIPSSEEIKRFENGIDIGGYITAKAKFDFIS------------- 176

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
              +  +S +KI ++EG+NRQVR+M   +G P + L+R A+GD  L NL  G WR +T+
Sbjct: 177 --SNKESSKVKIEIHEGKNRQVRKMCDAIGHPVITLMRIAIGDIKLGNLKEGAWRYLTE 233


>UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5KLG0_9FIRM
          Length = 261

 Score =  203 bits (517), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 63/192 (32%), Positives = 101/192 (52%), Gaps = 16/192 (8%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
             + NKP  V+    D+  R T+ + I     + ++ AGRLD+D+EGLL++TN+G L  R
Sbjct: 64  YFMLNKPAGVVSATEDKKER-TVIDLIKESKRKDLFPAGRLDKDTEGLLLITNDGQLAHR 122

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND-GPTLPAGAELVD----------E 146
           L  P K   KIYY +++GI T++ +     GV + D  PT+PA  E++           +
Sbjct: 123 LLSPKKHVDKIYYAKIKGIVTEEDVRLFEKGVHIGDEKPTMPAALEILSVQKERRKEKIK 182

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD- 205
              + P      + K    S + +T+ EGR  QV+RM   VG   + L R   G  +LD 
Sbjct: 183 EQKILPETKNETDEKEDGYSEIYLTIKEGRFHQVKRMFRAVGKEVVYLKRIQFGTLTLDP 242

Query: 206 NLANGEWREVTD 217
           +L  G++R++T+
Sbjct: 243 SLKPGQYRKLTE 254


>UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes RepID=Q11YT0_CYTH3
          Length = 562

 Score =  203 bits (517), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 62/221 (28%), Positives = 102/221 (46%), Gaps = 24/221 (10%)

Query: 3   QFIISENTMQK---TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           Q II           +   ++VK   S +   +    + +  +L NKP D +    DE  
Sbjct: 348 QLIIEGTVKVNGIVVTELGYKVKPGDSVKYNNKVLNPEKSVYVLLNKPKDFITTMEDEND 407

Query: 60  RKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           RKT+ + +     + +Y  GRLDR++ GLL+ TN+G L  +LT P  +  KIY V+++  
Sbjct: 408 RKTVMQLVANATKERIYPVGRLDRNTTGLLLFTNDGELAQKLTHPSNKVKKIYEVELDKP 467

Query: 117 PTQDALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
            T +  + + +G + L DGP     A ++                 S     + I ++EG
Sbjct: 468 ITAEDFDKIVDGKIHLFDGPVKVDEAAII-----------------SPSKKIIGIEIHEG 510

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RNR VRR+   +G+  L+L R      +  N+  G WR +T
Sbjct: 511 RNRIVRRIFESLGYDVLKLDRVMYAGLTKKNIPRGSWRYLT 551


>UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KY92_THERP
          Length = 282

 Score =  203 bits (516), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 17/199 (8%)

Query: 20  QVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGR 77
           +V     +     KP  ++P R I+ +KP   +    DE GRKT+ + + V + V   GR
Sbjct: 47  KVDPERQEICVDGKPLHSEPRRYIVLHKPVGYITTTADEYGRKTVLDLVQVPERVVPVGR 106

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LDRDS GLL+LTN+G L  R+T P     K Y V V+G P  +  EALR GV ++  P  
Sbjct: 107 LDRDSSGLLLLTNDGDLIYRITHPRYELEKEYEVLVDGFPPPEVEEALRRGVPVDGRPVR 166

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
               E +               R     +  ++ ++EGRNR +RR+   VG+P LRL R 
Sbjct: 167 IRRLEAI---------------RVEPQGTVYRVVIHEGRNRIIRRVFERVGYPVLRLQRV 211

Query: 198 AMGDYSLDNLANGEWREVT 216
            +G   L +L  G WR++T
Sbjct: 212 RVGPLRLGDLPPGRWRDLT 230


>UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales RepID=A6LIA0_PARD8
          Length = 495

 Score =  203 bits (516), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 55/223 (24%), Positives = 98/223 (43%), Gaps = 28/223 (12%)

Query: 7   SENTMQKTSFRNHQV---------KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDE 57
           ++  +QK + + + V          R        +  + +    I+ NKP + +    D 
Sbjct: 277 ADEFIQKGAVKVNDVVVTELGTKITRQDVVTFNEKPVQIESKVYIVLNKPKNCVTTSDDP 336

Query: 58  AGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
             R T+ + +     + +Y  GRLDR++ G+L+LTN+G L ++LT P  +  KIY+V ++
Sbjct: 337 QERLTVMDLVKNACQERIYPVGRLDRNTTGVLLLTNDGDLASKLTHPSFKKKKIYHVWLD 396

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
                + +E + NG+ L DG           E                   S + I ++ 
Sbjct: 397 KNVAIEDMEKIANGLELEDGEIHADAISYASED----------------DKSQVGIEIHS 440

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           GRNR VRR+   +G+   +L R      +  NL  G+WR + +
Sbjct: 441 GRNRIVRRIFESLGYHVTKLDRVYFAGLTKKNLGRGKWRYLNE 483


>UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=A3CPQ5_STRSV
          Length = 242

 Score =  203 bits (516), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 59/213 (27%), Positives = 102/213 (47%), Gaps = 18/213 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           I+   +++ +     VK         +   N+     L NKP  V+   +D+ GRKT+ E
Sbjct: 29  INGQVVRELATN---VKSGDRVEVEGQPIYNEEKVYYLLNKPRGVISSVSDDKGRKTVVE 85

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P   + +Y  GRLD D+ G+L+LTN+G     +  P     K+Y  +V+G+  ++ L 
Sbjct: 86  LLPQVKERIYPVGRLDWDTSGILILTNDGDFTDEMIHPRNEIDKVYVARVKGLANKEVLR 145

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            L  G+ +    T PA  E++             +   +   S +++T++EGRN QV++M
Sbjct: 146 PLTRGIEIEGRKTKPAVYEII-------------KVDPAKNRSVVQLTIHEGRNHQVKKM 192

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VG    +L R   G   L  L  GE+R+++
Sbjct: 193 FQAVGLQVDKLSRTRFGHLDLTGLKPGEYRKLS 225


>UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae RepID=Q2K4S3_RHIEC
          Length = 312

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 57/192 (29%), Positives = 90/192 (46%), Gaps = 18/192 (9%)

Query: 29  STRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGL 85
                   +    ++ NKP  ++    D  GR T+ + +    +  +   GRLD+ SEGL
Sbjct: 119 VDGLVIAAEAKIYLMLNKPRGLVTTRQDPEGRPTVYDCLKNFDIPHLSPVGRLDKASEGL 178

Query: 86  LVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVD 145
           L+ TN+      L  P     K Y+VQ++ +   + + A+ +G+  +DG  L A A    
Sbjct: 179 LLFTNDTEFAQTLLDPLTHVTKTYHVQIDRLMDDEEIAAMTSGIR-HDGELLTAAA---- 233

Query: 146 EPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD 205
                       R R+    SW+++ L EGRNRQ+RRM   +G   LRL+R A+G   L 
Sbjct: 234 ----------TRRLRQGDRNSWIEVELDEGRNRQIRRMLEALGAECLRLVRVAIGGLELG 283

Query: 206 NLANGEWREVTD 217
            L  G  R +T+
Sbjct: 284 ELPKGAVRALTE 295


>UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organisms
           RepID=A4CJ52_9FLAO
          Length = 303

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 59/209 (28%), Positives = 96/209 (45%), Gaps = 19/209 (9%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ- 70
           +  +   ++V+     R   R  + +    +L NKP + +    DE GR+T+ E I    
Sbjct: 101 KTITEMGYKVQPTDEVRFDGRLLQRERKEYVLLNKPRNFITTTRDEKGRRTVMELISRAS 160

Query: 71  --GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNG 128
              +   GRLDR++ GLL+ TN+G L  +LT P     KIY+V+++       L  LR G
Sbjct: 161 NARLVPVGRLDRNTTGLLLFTNDGELAKKLTHPKHGVRKIYHVELDKTFKSADLGKLREG 220

Query: 129 VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVG 188
           + L DG      A  +D                      + + L+ GRNR VRR+  H+G
Sbjct: 221 LELEDGRIEVDEASYID----------------GASKKEVGVELHSGRNRIVRRIFEHLG 264

Query: 189 FPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +  ++L R  +   +  +L  G WR +T+
Sbjct: 265 YQVVKLDRVVLAGLTKKDLPRGHWRHLTE 293


>UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5V220_ROSS1
          Length = 624

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 63/201 (31%), Positives = 103/201 (51%), Gaps = 18/201 (8%)

Query: 20  QVKRFSSQRSTRRKPENQ--PTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAG 76
           +V     +     +P  +      ++ +KP  V+    D  GR T+ + + ++  ++  G
Sbjct: 43  RVDPEHDEILVDGRPIGKIHHRTYVMLHKPAGVVSTTDDPQGRPTVIDLVNLEQRLFPVG 102

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLD DSEGLL+LT++G L  +LT P  +  K Y V +   P+  AL A R GV L+   T
Sbjct: 103 RLDYDSEGLLLLTDDGELTQKLTHPSYQVEKEYRVLLNEAPSPAALRAWRTGVELDGVKT 162

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
            PA  EL++               ++   +W+++ L+EGR RQ+R +   +G+   RLIR
Sbjct: 163 APAWVELIE---------------RTPDGAWVRVILHEGRKRQIREVARVLGYEVRRLIR 207

Query: 197 YAMGDYSLDNLANGEWREVTD 217
              G  +L +L +G WR +TD
Sbjct: 208 VREGPLTLGDLPSGTWRFLTD 228


>UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E n=1 Tax=Cyanobium
           sp. PCC 7001 RepID=B5INL2_9CHRO
          Length = 243

 Score =  201 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 102/196 (52%), Positives = 124/196 (63%), Gaps = 12/196 (6%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVL 88
              P ++PT  +LF+KPY VL QFT E G +   L +FI V GVYAAGRLD DSEGLL+L
Sbjct: 6   EELPASRPTT-LLFHKPYGVLSQFTPEPGSRWRCLADFIAVPGVYAAGRLDADSEGLLLL 64

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIP--TQDALEALRNGVTLNDGPTLPAGAELVDE 146
           T NG LQ RLT P     + Y+VQVEG      +AL+ LR GV +    T PA    + +
Sbjct: 65  TANGRLQQRLTDPAFGHWRTYWVQVEGEAGQRPEALQQLRQGVVIQGRLTRPALVRCLSD 124

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM------G 200
           P  L  R+PPIR+R +IP SWL++ L EGRNRQVRRMTA VG PTLRLIR A+       
Sbjct: 125 P-KLPERDPPIRQRATIPVSWLELQLQEGRNRQVRRMTARVGLPTLRLIRVAIDLMDGEA 183

Query: 201 DYSLDNLANGEWREVT 216
             SL  L  G+WR V+
Sbjct: 184 PLSLSGLKPGDWRRVS 199


>UniRef50_Q8ZGM2 Ribosomal small subunit pseudouridine synthase A n=134
           Tax=Gammaproteobacteria RepID=RSUA_YERPE
          Length = 235

 Score =  201 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 59/223 (26%), Positives = 99/223 (44%), Gaps = 32/223 (14%)

Query: 2   RQFIISENTMQKTSFR--NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           ++  I    ++  + +    Q  RF      +        R  + NKP   +    D   
Sbjct: 25  KRVTIDGEVVKSGAIKLTPEQDVRFDGNPLQQMVG----PRYFMLNKPQGYVCSTEDP-D 79

Query: 60  RKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
             T+  F+       ++AAGRLD D+ GL+++T++G    R+T P     K Y V +E  
Sbjct: 80  HPTVLYFLDEPVAYKLHAAGRLDIDTTGLVLMTDDGQWSHRVTSPRHHCEKTYLVTLEHP 139

Query: 117 PTQDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
            + D  +   +GV L +    T PA  ++++                      +++T+ E
Sbjct: 140 LSDDTAQQFADGVQLYNEKSLTKPAQLDVIEPQ-------------------RVRLTISE 180

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           GR  QV+RM A VG   + L R  +GD +L D+LA GE+R +T
Sbjct: 181 GRYHQVKRMFAAVGNRVIELHRERIGDITLDDDLAPGEYRPLT 223


>UniRef50_Q1LLR3 Pseudouridine synthase n=15 Tax=Proteobacteria RepID=Q1LLR3_RALME
          Length = 631

 Score =  201 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 57/192 (29%), Positives = 84/192 (43%), Gaps = 19/192 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEG 84
           +   RK   +P RV+L++KP   +   +D  GR T+ + +P        A GRLD ++EG
Sbjct: 285 KLIHRKVTTKPPRVLLYHKPSGEIVSQSDPEGRPTVFDSLPRIKNGKWVAVGRLDFNTEG 344

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ T +G +  R   P     + Y V+  G   +   + L +G+ L+DG          
Sbjct: 345 LLIFTTSGDIANRFMHPRYGVEREYAVRTLGELAEADRQRLLHGIQLDDGEANFLRI--- 401

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W  + L EGRNR+VRRM   VG    RLIR   G + L
Sbjct: 402 ------------ADGGGEGVNQWYHVALTEGRNREVRRMFEAVGLTVSRLIRTRYGQFLL 449

Query: 205 -DNLANGEWREV 215
              L  G W+E+
Sbjct: 450 PRGLKRGRWQEL 461


>UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=C4ZJR2_THASP
          Length = 379

 Score =  201 bits (512), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 63/194 (32%), Positives = 96/194 (49%), Gaps = 24/194 (12%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEG 84
           R T+R P     RV++++KP   +    D  GR T+ E +P+       A GRLD ++ G
Sbjct: 172 RFTQRSP-----RVLIYHKPEGEIVSRDDPEGRPTVFERLPILRKGRWLAVGRLDFNTSG 226

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ TN+G L  +L  P     + Y V++ G  T++ +++L +G+ L DG   PA   L+
Sbjct: 227 LLLFTNDGDLANKLMHPRYELEREYAVRILGELTEEQVKSLTDGIQLEDG---PAKFNLL 283

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
            +            E       W ++T+ EGRNR+VRRM   VG    RL+R   G   L
Sbjct: 284 RD------------EGGEGANHWYRVTISEGRNREVRRMFEAVGLTVSRLMRVRYGSVEL 331

Query: 205 D-NLANGEWREVTD 217
              L  G W E+ +
Sbjct: 332 PARLKRGMWMEMPE 345


>UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter RepID=Q6F9V5_ACIAD
          Length = 239

 Score =  201 bits (512), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 57/216 (26%), Positives = 94/216 (43%), Gaps = 23/216 (10%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           I +   +   +R H +  F+ Q   +     +    I+ NKP             +++  
Sbjct: 33  IQDEIQKDLKYRIHDLTDFNFQVFDQNYVYRE-KVYIILNKPKGFECSHQ-PHHHQSVFS 90

Query: 66  FIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +P     + + A GRLD+D+ GLL+LT++G     LT P K   K+Y+V      T D 
Sbjct: 91  LLPDLLIQRNIAAVGRLDQDTTGLLLLTDDGQYLHTLTHPKKHVPKVYHVATIDPITVDQ 150

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +  L  GV L++   + A   +                   +  + L +T+++G   QV+
Sbjct: 151 MHQLEQGVELHNEKGVFAATNVT-----------------LLNETQLSMTIHQGVYHQVK 193

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RM A VG     L R+ +G   L NLA GEW  +T+
Sbjct: 194 RMIAAVGNKVTALHRHKIGQLELPNLAEGEWMYLTE 229


>UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZ55_9FIRM
          Length = 250

 Score =  201 bits (512), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 53/184 (28%), Positives = 93/184 (50%), Gaps = 3/184 (1%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGAL 94
           + T  I  NKP   +   +DE GR+T+ + +    + ++  GRLD+DSEGL++LTN+G L
Sbjct: 58  KKTVYIAMNKPCGYVCTVSDELGRRTVYDLLTDIDERLFTIGRLDKDSEGLILLTNDGDL 117

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
             +L  P ++  K Y V V G+P  + ++ L  G+T++   +     + V        + 
Sbjct: 118 AQKLLSPKRKIEKNYEVVVRGVPGANDIKKLSGGITIDVEISQTKQNKPVKSIVKYHTKP 177

Query: 155 PPIRERKSIPTS-WLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
             I E         L + + EG+ RQ+R+M   +G   ++L R       L +L  GE+R
Sbjct: 178 AKIFEIGQKQGDMKLSMIIKEGKKRQIRKMFDVIGHEVIKLKRVKFAGIELGDLRPGEFR 237

Query: 214 EVTD 217
            +++
Sbjct: 238 HLSE 241


>UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria RepID=Q3AVD5_SYNS9
          Length = 247

 Score =  201 bits (512), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 70/182 (38%), Positives = 93/182 (51%), Gaps = 18/182 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGA 93
           Q  RV L NKP  V+    D  GR T+ + +P Q   G++  GRLD DS G L+LT+ G 
Sbjct: 61  QEPRVFLLNKPVGVICSCRDPQGRATVLDCLPHQERSGLHPVGRLDADSRGALLLTDQGE 120

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  RLT P     K Y V V GIP+  AL   R+G+ L+   T PA    +         
Sbjct: 121 LTLRLTHPRYNHAKTYRVLVRGIPSSQALRRWRDGLLLDGRLTRPARVHCL--------- 171

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                 R    +S L++ L EGRNRQ+RR+   +G P + L R A+    LD+LA G WR
Sbjct: 172 ------RSRGASSLLEVELKEGRNRQIRRVAELLGHPVIDLQRVAIDGIRLDDLAEGCWR 225

Query: 214 EV 215
            +
Sbjct: 226 RL 227


>UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales RepID=B4U4Q4_STREM
          Length = 266

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 57/213 (26%), Positives = 99/213 (46%), Gaps = 18/213 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   +   +     VK             N+     L NKP  V+   +D+ GR+T+ +
Sbjct: 55  LNGQVVTDLAT---TVKSGDLVEIEGSPIYNEEKVYYLLNKPRGVISSVSDDKGRQTVID 111

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P   + +Y  GRLD D+ GLL+LTN+G    ++  P     K+Y  +V+G+ T+++L 
Sbjct: 112 LLPQVKERIYPVGRLDWDTSGLLILTNDGDFTDKMIHPRNEIDKVYLARVKGVVTKESLR 171

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            L  GV ++   T PA   ++             R       S +++T++EGR+ QV++M
Sbjct: 172 PLTRGVVIDGKKTKPARYRII-------------RVEPDKNRSIVELTIHEGRHHQVKKM 218

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VG    +L R   G   +  L  GE R ++
Sbjct: 219 FEAVGHLVDKLSRTQFGSLDVRGLKPGEARRLS 251


>UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C4P7_9PLAN
          Length = 352

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 67/214 (31%), Positives = 110/214 (51%), Gaps = 19/214 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           +  + + +   +     +F      R +   QP R  L NKP   L    D AGR+ + +
Sbjct: 51  VDGDVITELGAKIDPETQFIEVDGERVRL--QPRRYYLLNKPSGFLCTNNDPAGRRRVVD 108

Query: 66  FIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
             P   Q ++  GRLD +SEGL+++TN+G L  RL  P  R  + Y+VQV G P ++ L+
Sbjct: 109 LFPNDGQRLFTVGRLDENSEGLILVTNDGELAQRLAHPRYRVARTYHVQVVGNPPREKLD 168

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            LR GV   +G    +G + +               +K   +++L++TL+EG+NR++RRM
Sbjct: 169 ELRKGVRFKEGVFRVSGLKYL---------------KKQGKSAFLELTLHEGQNREIRRM 213

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            A +G   ++L+R   G  +L  L  GE R ++D
Sbjct: 214 MARIGHKVIQLVRIRFGPLNLGKLKTGESRRLSD 247


>UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredinis DSM 17216
           RepID=B0MSS4_9BACT
          Length = 451

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 57/200 (28%), Positives = 91/200 (45%), Gaps = 20/200 (10%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAG 76
           +V+     +    + E +    ++ NKP   +    D    KT+ E +     + +Y  G
Sbjct: 256 KVQPTDEVKFNDSRVEGEKKVYLVLNKPKGYVTSLDDPHADKTVMELVKDACTERIYPVG 315

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLD++S GLL+ TN+G L  +LT P  +  KIY V ++   T+  +E +  G+TL DG  
Sbjct: 316 RLDKNSVGLLLFTNDGDLTRQLTHPSFQKKKIYQVSLDKPLTKADMEQIAQGITLEDGEI 375

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
                  V E                   + + I ++ GRNR VRR+  H+G+   +L R
Sbjct: 376 YADEIAYVKE-----------------DKTEVGIEIHSGRNRIVRRIFEHLGYAVKKLDR 418

Query: 197 YAMGDYSLDNLANGEWREVT 216
                 S  NL  G+WR +T
Sbjct: 419 VYYAGLSKKNLKRGQWRFLT 438


>UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=Q3AI58_SYNSC
          Length = 230

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 93/185 (50%), Positives = 114/185 (61%), Gaps = 10/185 (5%)

Query: 42  ILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L NKPY VL QFT E G +   L +F+ V  VYAAGRLD DSEGLL+LT+NG LQ RLT
Sbjct: 19  LLLNKPYGVLSQFTSEEGSRWRCLSDFVDVPQVYAAGRLDADSEGLLILTSNGRLQQRLT 78

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV--DEPAWLWPRNPPI 157
            P     + Y+ QVEG P  + L+ L +GV +    TLPA A  +   +   L  R P I
Sbjct: 79  DPRFGHWRSYWAQVEGTPNTEQLQQLCDGVVVQGRRTLPAKARWLQGQDLPQLPERTPQI 138

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG------DYSLDNLANGE 211
           R R +IPT+WL+++L EGRNRQVRRMTA VG PTLRL+R  +          L  L  G 
Sbjct: 139 RFRAAIPTNWLQLSLSEGRNRQVRRMTAAVGLPTLRLVRCCIDLMDNGPPLDLTGLQPGS 198

Query: 212 WREVT 216
           WR VT
Sbjct: 199 WRTVT 203


>UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Z61_SOLUE
          Length = 264

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 68/201 (33%), Positives = 98/201 (48%), Gaps = 18/201 (8%)

Query: 19  HQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAA 75
           H V     + +   KP    T+  IL  KP   L  + D  GR T+   +   G  +   
Sbjct: 52  HWVDPDHDKVTLEGKPLKAATKSYILLYKPKGYLTTYRDPEGRPTVYALLGDVGKWLSPV 111

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP 135
           GRLD D+ GLLVLTN+     R+T P  +  K Y ++   + + + +E LR GV L+DGP
Sbjct: 112 GRLDLDTSGLLVLTNDNDFAERITNPEHKVPKTYQIKAATVLSDEQIERLRAGVELSDGP 171

Query: 136 TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLI 195
           T PA  +               R R     ++L++T+ EGRNRQVRRM   V     +L+
Sbjct: 172 TRPAEVK---------------RLRDGPKHTFLEMTITEGRNRQVRRMLEAVESKVSKLV 216

Query: 196 RYAMGDYSLDNLANGEWREVT 216
           R A+G   +  L  G+WR +T
Sbjct: 217 RTAIGPVRIGELPIGKWRNLT 237


>UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutactus ATCC 27759
           RepID=A8SYF2_9FIRM
          Length = 239

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 19/200 (9%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRL 78
           +   + +   ++      R  L NKP   +    D    +T+ + +     + ++  GRL
Sbjct: 43  EDTDTIKYNGKQLCYSKYRYFLLNKPAGCVSATKDNV-HQTVIDLLNGENTKDLFPVGRL 101

Query: 79  DRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL-NDGPTL 137
           D D+EGLL++TN+G L   L  P     K YY  ++G      +   + G+ + +D PTL
Sbjct: 102 DLDTEGLLIITNDGRLAHHLLSPAHHIAKTYYADIDGYVDDQTISLFKQGIDIGDDTPTL 161

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           PA  ++++               +S  +S +++T+ EGR  QV+RM   V      L R 
Sbjct: 162 PASLKIIEAD-------------RSTGSSRIELTITEGRFHQVKRMFQAVNMSVTFLKRI 208

Query: 198 AMGDYSL-DNLANGEWREVT 216
           +MG+  + D+L  G +RE+T
Sbjct: 209 SMGNLHIADDLPTGSYRELT 228


>UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomonas noxia ATCC 43541
           RepID=UPI0001BCEF2E
          Length = 296

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 61/183 (33%), Positives = 91/183 (49%), Gaps = 17/183 (9%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGA 93
           ++    IL NKP   L    D+ GRKT+ + +P     +Y  GRLD D+EG+L++TN+GA
Sbjct: 60  DEKRFYILLNKPRGYLSTARDDRGRKTVLDLLPDFPARLYPVGRLDADTEGVLLITNDGA 119

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           +   L  P     K+Y+ +V G  T+  L  LR G+ L DG T  A   ++         
Sbjct: 120 ITQGLLHPRFEIDKVYHAEVAGPVTEGGLTRLRRGILLEDGMTASAKLRIL--------- 170

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                 R     + ++  ++EGRNRQVRRM A +G     L R      +L  L+ G +R
Sbjct: 171 ------RADKGYTVVETIIHEGRNRQVRRMFAAIGCRVCALRRVRFAMLTLRGLSCGSFR 224

Query: 214 EVT 216
            +T
Sbjct: 225 HLT 227


>UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=A6GNL7_9BURK
          Length = 458

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 25/225 (11%)

Query: 1   MRQFIISE--NTMQKTSFRNHQVKRFSSQRST----RRKPENQPTRVILFNKPYDVLPQF 54
           M + I++   +   + +    +V      R      +RK +++P RV++++KP   +   
Sbjct: 86  MEELIVAGRVSVNAEPAHLGQRVLPTDQVRVNGKLIQRKNKSKPPRVLIYHKPAGEIVSM 145

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D  GR T+ + +P        A GRLD ++EGLL+ T++G L  RL  P     + Y V
Sbjct: 146 DDPQGRTTVFQKLPKISNGKWIAVGRLDFNTEGLLLFTSSGELANRLMHPRYEVQREYAV 205

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           ++ G  +++  + L  G+ L DG   PA    VD                     W K+ 
Sbjct: 206 RILGELSEEQRQQLLTGIQLEDG---PAKFLYVDAAGG------------EGANRWYKVG 250

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           L EGRNR+VRRM         RLIR   GD  +   L  G   E+
Sbjct: 251 LKEGRNREVRRMFEACNLTVSRLIRTRFGDIMMPSTLKRGRHMEM 295


>UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VG32_9BACT
          Length = 279

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 68/215 (31%), Positives = 97/215 (45%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++ N +Q  S +    K   +      +P  +    ++ NKP   +    DE GRKT
Sbjct: 65  RIAVNGNLVQDLSRQIIPGKDKVTLDGKPIQPAKEKF-YLILNKPRGYVVSQNDELGRKT 123

Query: 63  LKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +   +P +G  +  AGRLD++SEGLL  TN+ AL   LT P  +  K+Y V +       
Sbjct: 124 VYSLLPPKGKQLAYAGRLDKESEGLLFFTNDTALINLLTHPKNKVEKVYRVDINRPLNNM 183

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  LR GV +  G TLPAG                  + K+     LKI + EGR RQ+
Sbjct: 184 ELNMLRKGVEIEGGKTLPAGI---------------FVKSKNANGMTLKIVITEGRKRQI 228

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R+M   VG     L R   G   L +L  G WR +
Sbjct: 229 RQMIEAVGAKVTYLKRLQFGPLKLKDLPVGRWRLL 263


>UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C7P2_SPHTD
          Length = 337

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 69/215 (32%), Positives = 108/215 (50%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +++   R    ++       R +PE +  R I+ NKP   +   +DE GR+T
Sbjct: 27  RVTVDGQVVRELGVRVDPERQEIRVDGKRLRPERR--RYIMLNKPPGYITTVSDERGRRT 84

Query: 63  LKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + + V + V  AGRLDR + GLL+LTN+G L  R+T P     K Y V V+G P  + 
Sbjct: 85  VMDLVQVPERVVPAGRLDRPTAGLLLLTNDGDLLFRITHPRYELEKEYEVLVDGHPPPEV 144

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L+ LR GVT++    +P     +               R     + L+I ++EGRNR VR
Sbjct: 145 LDQLRRGVTVDGERVVPDQVRPL---------------RIEEAGTVLRIVIHEGRNRIVR 189

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RM   VG+P L+L R  +G   +  +  G WR++T
Sbjct: 190 RMMDRVGYPVLKLTRTRIGPIHVRGVPLGAWRDLT 224


>UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termitidis ATCC 33386
           RepID=D1AL84_SEBTE
          Length = 233

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 72/216 (33%), Positives = 102/216 (47%), Gaps = 25/216 (11%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           IS N    T  + H  +         ++ E +    I+ NKP DV+    DE  R T+ +
Sbjct: 27  ISVNDEVVTEAKTHIDEDNDFVAFDGKRIEFKEFLYIMLNKPQDVISATDDERHR-TVLD 85

Query: 66  FIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +       G++  GRLD+D+EGLLVLTN+G +   L  P K   K YYV+++   +++ 
Sbjct: 86  LLEEPLTKVGLFPVGRLDKDTEGLLVLTNDGKMAHELLSPKKHVPKRYYVELKKTLSKEE 145

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
              L NGV L    T PA  E + E                     + I + EG+  QV+
Sbjct: 146 AAILENGVELETFTTKPAKVEFITED-------------------KVYIIISEGKYHQVK 186

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           RM   VG   L L R  MG+  LD NLA GE+RE+T
Sbjct: 187 RMFKCVGNRVLFLKRTGMGNLGLDENLAPGEYRELT 222


>UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepID=A2RP35_LACLM
          Length = 328

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 63/222 (28%), Positives = 104/222 (46%), Gaps = 22/222 (9%)

Query: 3   QFIISENTMQKTSFR---NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           +  ++    +   F+   N +   F  Q         Q     L NKP  V+    D   
Sbjct: 112 RVTVAGEIQRDGRFQVDKNSRQVAFDGQILD-----YQEYYYYLLNKPQGVVSATKDNV- 165

Query: 60  RKTLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
            KT+ + +      + ++  GRLD+++EGLL+LTN+GAL   LTQP K   K Y+ +++G
Sbjct: 166 FKTVVQLLSEKDFRKDIFPVGRLDKNTEGLLILTNDGALGHDLTQPKKHVEKEYFARIDG 225

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             T + +     G+TL +G            P  L+       + +S   S +++ ++EG
Sbjct: 226 KVTDEIINKFAEGLTLKNGEKA--------RPGELFVEKTYKGDSQSGWVSEIRVIIHEG 277

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           +  QV+RM   V    L L R  MG+ +LD +LA G +R +T
Sbjct: 278 KFHQVKRMFEAVEMYVLYLKRIRMGNLALDSDLALGAYRPLT 319


>UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium RepID=C6JI84_FUSVA
          Length = 236

 Score =  199 bits (508), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 16/197 (8%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDR 80
           K     R  + +   +     + NKP +VL    D+ GRKT+ + I   + ++  GRLD 
Sbjct: 46  KDEIYIRGKKIEKHTEKKVYYILNKPLEVLSSSKDDRGRKTVVDLINCKERIFPIGRLDY 105

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAG 140
           ++ GL++LTN+G L  R+  P     K YYV+V G   ++ +E L+NGV L+DG TLPA 
Sbjct: 106 NTSGLIILTNDGELFNRIIHPKAEIFKEYYVKVLGEIKENNVELLKNGVELDDGITLPAN 165

Query: 141 AELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
             ++               R+    + L + + EGRNRQVRRM   +  P + L R  +G
Sbjct: 166 VRIL---------------RREKGKTELLVAIREGRNRQVRRMMDKINHPVITLRREKIG 210

Query: 201 DYSLDNLANGEWREVTD 217
           + SL NL  GE+RE+T+
Sbjct: 211 NLSLGNLKLGEYRELTN 227


>UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196BAD7
          Length = 247

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 54/204 (26%), Positives = 85/204 (41%), Gaps = 15/204 (7%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQG 71
            +    +V +  +     +    +     LF KP   +   +DE  R  + ++     + 
Sbjct: 36  VTVLGTKVTKKDTICVNGKLINKEDKVYYLFYKPEKCVCTMSDEHDRTCVADYFADSNER 95

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           VY  GRLD D+ G L +TN+G     +  P     K+Y V V+G+ T+     L  G+ L
Sbjct: 96  VYPVGRLDYDTTGALFMTNDGEFANLIMHPSSHLEKVYEVSVKGLLTKAEKNQLEKGIYL 155

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
               TLP    +                 +   T+ L I L EG+NRQ+++M   VG P 
Sbjct: 156 EGVKTLPCEIAITGND-------------EEHGTTMLLIRLVEGKNRQIKKMFEEVGHPV 202

Query: 192 LRLIRYAMGDYSLDNLANGEWREV 215
            RL R  +G   L  L  G +R +
Sbjct: 203 KRLRRIMIGPIDLKGLTPGTYRRL 226


>UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae RepID=A4BW35_9FLAO
          Length = 305

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 58/207 (28%), Positives = 93/207 (44%), Gaps = 19/207 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQ 70
            +   ++V+     R        +  + IL NKP + +    D+ GRKT+ + I     +
Sbjct: 105 VTEMGYKVQPDDVVRFDGTGITPEQKKYILLNKPKNYITTMDDDRGRKTVMDLISNATKE 164

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            +Y  GRLDR++ GLL+ TN+G L  +LT P     K+Y+  ++       LE LR  V 
Sbjct: 165 RIYPVGRLDRNTTGLLLFTNDGELAKKLTHPKHDVRKLYHASLDKKLELKDLEKLRGEVL 224

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           +            VD                  P S + I ++ GRNR VR++  H+G+ 
Sbjct: 225 IEGKKVFIDAVSYVD----------------GQPKSEVGIEIHSGRNRIVRKIFEHLGYK 268

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVTD 217
             +L R    + +  NL  G WRE+T+
Sbjct: 269 VSKLDRVIFAELTKRNLPRGRWRELTN 295


>UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C4Z9Y4_EUBR3
          Length = 250

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 62/219 (28%), Positives = 97/219 (44%), Gaps = 24/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  I+     K   +              R  + Q     LFNKP   +    D     T
Sbjct: 37  QIAINGTVAAKPETKV--DTDADEVSVNGRIVKYQRYEYYLFNKPSGCVSATCDNV-HDT 93

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + ++I       ++  GRLD D+EGLL++TN+GAL   L  P K   K YY +++G  T 
Sbjct: 94  VMDYITDAVHDDLFPVGRLDIDTEGLLLITNDGALSHELLSPSKHVAKTYYARIDGEVTL 153

Query: 120 DALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           D +   + G+ +  + PT PA   +                +KS   S +++T+ EG+  
Sbjct: 154 DDIIRFKEGIDIGEEKPTKPAELVI----------------KKSGSVSEIELTITEGKFH 197

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           QV+RM   +G   + L R +MG   L D+L  G +R +T
Sbjct: 198 QVKRMFEALGKRVIYLKRISMGPLKLPDDLKTGTYRALT 236


>UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine bacterium 105
           RepID=Q6SI36_9BACT
          Length = 255

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 66/197 (33%), Positives = 101/197 (51%), Gaps = 13/197 (6%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLD 79
                +   R+    +P   +L  KP   +    D  GR+T+   I      VY  GRLD
Sbjct: 49  DLDDIRVDGRKVKTGRPRIYLLVCKPRGYVTTRFDPEGRRTILNLISNVREYVYPVGRLD 108

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
            DSEGL++LTN+G L ARLT P     ++Y V+V G+P+Q A+++LR+GV +N   T  +
Sbjct: 109 YDSEGLVILTNDGTLAARLTHPRYGVERVYEVRVRGVPSQAAIDSLRHGVLINGRRTASS 168

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
             + +              + KS   + L++ + EGRNRQVR+M   +G P +RL R  +
Sbjct: 169 SVKFLRR-----------LKAKSSENALLRVAIREGRNRQVRKMCEAIGHPVIRLRRTQI 217

Query: 200 GDYSLDNLANGEWREVT 216
           G     +L  G+ R +T
Sbjct: 218 GPLRDSSLKVGKHRLLT 234


>UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapolitana DSM 4359
           RepID=B9KC52_THENN
          Length = 240

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 106/217 (48%), Gaps = 24/217 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++ T+   +   +++      +   +  +      ILF KP   +    D    +T
Sbjct: 26  RVTVNDRTVLDPA---YKLSDKDVVKVDGKVIDLPEKVYILFYKPAGYVTSTRDPHS-ET 81

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + EF+P ++G++  GRLD+D+EGLL++TN+G    R+  P  +  K Y V+VEG  T+D 
Sbjct: 82  IMEFLPDIKGIFPVGRLDKDAEGLLLVTNDGEFAHRVISPRWKVEKEYVVKVEGEITEDK 141

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           LE LR GV+L DG    A                     + I    +KI + EG+  QV+
Sbjct: 142 LEKLRRGVSLRDGFFAKAK------------------HVEKISNDTVKIVITEGKYHQVK 183

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           RM A VG  T+ L R  +G   L   +  GE+R +++
Sbjct: 184 RMMAAVGLKTIHLKRVRIGGLRLPQEMKPGEYRFLSE 220


>UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q3J464_RHOS4
          Length = 508

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 66/215 (30%), Positives = 105/215 (48%), Gaps = 19/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++  T+   +       R +     +     +P R+ L+ KP  ++   +DE GR+T
Sbjct: 33  RIAVNGRTIDSPALNVGPKDRIT--VDGQPLAPPEPARLWLYYKPEGLVTSASDEKGRET 90

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P  +  V + GRLD +SEGLL+LTN+G L+ RL  P     + Y V+V+G PT  
Sbjct: 91  VFDHLPEGMPRVMSVGRLDLNSEGLLLLTNDGELKRRLELPSTGWLRKYRVRVKGNPTDA 150

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            LE LR G+T+      P    L               +R     +WL + L EG+NR++
Sbjct: 151 DLEPLRKGITVEGESFQPMTVSL---------------DRVQGANAWLTVGLREGKNREI 195

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RR  + +G    RLIR + G + L+ L  G   EV
Sbjct: 196 RRAMSALGLTVNRLIRVSYGPFRLNELEPGMVEEV 230


>UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae RepID=A0JV58_ARTS2
          Length = 406

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 62/187 (33%), Positives = 89/187 (47%), Gaps = 18/187 (9%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVL 88
           R   ++    ++FNKP  V+    D  GR  + +F+     + ++  GRLD  +EGLL+L
Sbjct: 221 RIQLDENMVYMVFNKPKGVVSTMEDPDGRPCISDFVRNTHGERLFHVGRLDVATEGLLLL 280

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN+G L  RLT P     K Y VQV G   Q     L+ GV L DG       +LVD   
Sbjct: 281 TNDGELANRLTHPSYEVPKTYLVQVRGPFPQGIGAQLKAGVELEDGMASVDSFKLVD--- 337

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
                        +     +++ L+ G+NR VRR+   VGFP LRL+R  +G   L +  
Sbjct: 338 ------------STPGHVLIEVVLHSGKNRIVRRLFDAVGFPVLRLVRVKVGPIGLGDQR 385

Query: 209 NGEWREV 215
            G  R +
Sbjct: 386 QGSIRNL 392


>UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales RepID=B1XJP9_SYNP2
          Length = 259

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 61/190 (32%), Positives = 88/190 (46%), Gaps = 20/190 (10%)

Query: 32  RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-----GVYAAGRLDRDSEGLL 86
           +  E       L +KP  V+    D  GR T+ + +P       G++  GRLD  S G L
Sbjct: 57  KATERPRHYYYLIHKPKGVVSTCADPKGRSTVLDLLPPPLRQGKGIHPIGRLDAQSTGAL 116

Query: 87  VLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE 146
           +LTN+G     LT P     K Y V ++G   +  L+  R GV L D  TLP    L   
Sbjct: 117 LLTNDGNFTLALTHPRYHIPKTYRVWLKGKVPEHVLDQWRQGVMLGDRRTLPTQIHLKT- 175

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN 206
                          +   + + I L EGRNRQ+RR+   +GFP ++L R A+G+  L +
Sbjct: 176 --------------ITQDKTCIDIMLTEGRNRQIRRVAEQLGFPVVKLHRLAIGNLHLGD 221

Query: 207 LANGEWREVT 216
           L  G+ R +T
Sbjct: 222 LQRGQARPLT 231


>UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_1464 n=4 Tax=Bacteria
           RepID=Y1464_AQUAE
          Length = 249

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 64/214 (29%), Positives = 97/214 (45%), Gaps = 20/214 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQF-TDEAGRKTLK 64
           ++   ++    + +            +  + Q  R I+ NKP   L Q      GRKT++
Sbjct: 32  VNGEVVRSLGVKVN--PEVDIVEVDGKPVKPQRKRYIILNKPCCYLTQLGRSPDGRKTIE 89

Query: 65  EFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
           E I    + V+  GRLD ++EGLL+LTN+G L  R+  P  +  K+Y   VEG   Q  L
Sbjct: 90  ELIKDIPERVFPVGRLDYNTEGLLILTNDGELANRILHPRYKLPKVYLALVEGKVDQKTL 149

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
           + ++ G+ L DG   P    +V               R     + L+IT +EGR   V+R
Sbjct: 150 KRMKQGIELEDGFAKPDNIRIV---------------RYEGKNTLLEITFHEGRKHLVKR 194

Query: 183 MTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
                G    RL R A+G   L  L+ G+WRE+ 
Sbjct: 195 FLGAFGHKVKRLKRIAIGPIKLGKLSPGKWRELN 228


>UniRef50_Q38VQ0 Pseudouridine synthase n=6 Tax=Lactobacillus RepID=Q38VQ0_LACSS
          Length = 239

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 57/207 (27%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV----Q 70
               +QV   +           Q     L NKP  V+   TD    KT+ +        +
Sbjct: 35  KEAKYQVTPETVVYVDDEPIRYQTNFYWLLNKPAGVISATTDPQ--KTVMDLFAPADYRE 92

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            ++  GRLD+D+ GLL++TN+G L   L  P K   K Y  ++ G+ T         G+ 
Sbjct: 93  DLFPVGRLDKDTTGLLLITNDGDLAHDLLSPKKHVAKTYRAKIAGVVTAADQAQFAAGLK 152

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L D    PA   ++             R   +   S +++ ++EG+  QV+RM   VG  
Sbjct: 153 LRDFDAQPAQLTIL-------------RTDTARQESLIEVEIHEGKFHQVKRMFHAVGKE 199

Query: 191 TLRLIRYAMGDYSLD-NLANGEWREVT 216
            L L R  MG  SL  +L  G++R +T
Sbjct: 200 VLTLERIKMGPLSLPADLKRGQYRALT 226


>UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales RepID=C7H5G4_9FIRM
          Length = 294

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 65/202 (32%), Positives = 98/202 (48%), Gaps = 20/202 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAA 75
           N  V     +R      +NQ    +   KP   +   +DE GRKT+ E +      +Y  
Sbjct: 63  NRDVLHVDDERIY--IQKNQQLYYLALYKPRGYVTTASDELGRKTVMELVSDIPARLYPV 120

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG- 134
           GRLD+DSEGLL++TN+GA    +T P     K+Y V V+    +  +  + +GV L+DG 
Sbjct: 121 GRLDKDSEGLLLMTNDGAFAQAVTHPSGGISKLYRVTVQPRADESQILKMSSGVVLDDGT 180

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
            T+P    +V +                   + +++TL EG+NR++RRM   VG   +RL
Sbjct: 181 KTMPCAINVVTDEP---------------GRTVMEMTLKEGKNREIRRMCEAVGLEVVRL 225

Query: 195 IRYAMGDYSLDNLANGEWREVT 216
            R A G   L  L  G +RE+T
Sbjct: 226 KRNAEGVVKLGMLKPGTYRELT 247


>UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales RepID=Q47QM5_THEFY
          Length = 375

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 91/195 (46%), Gaps = 20/195 (10%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-----VQGVYAAGRLDRD 81
           +    R   +Q  R    NKP  V+    D  GR T+ ++        + ++  GRLD D
Sbjct: 183 RVDGMRVVTSQNLRYYALNKPRGVVSTMFDPEGRPTIGDYAAQIGPIEERLFHVGRLDTD 242

Query: 82  SEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGA 141
           +EGL++LTN+G L  RLT P  +  K Y  +V G   +D +  +R GV L+DG       
Sbjct: 243 TEGLILLTNDGELANRLTHPRYKVTKTYLAKVPGPVPRDVIRQIRKGVELDDGFVKVDSF 302

Query: 142 ELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 201
            ++D                  P + ++I L+EGR   VRR+   VG P   L R  +G 
Sbjct: 303 RVIDNIE---------------PKALVEIRLHEGRKHIVRRLMKAVGHPVSDLARTQIGP 347

Query: 202 YSLDNLANGEWREVT 216
             L+NL +G  R +T
Sbjct: 348 VGLNNLKSGTIRALT 362


>UniRef50_A3JIZ1 Pseudouridine synthase n=1 Tax=Marinobacter sp. ELB17
           RepID=A3JIZ1_9ALTE
          Length = 367

 Score =  198 bits (505), Expect = 8e-50,   Method: Composition-based stats.
 Identities = 58/218 (26%), Positives = 86/218 (39%), Gaps = 19/218 (8%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           R  +  +            V     +R           RV+++NKP   +    D  GR 
Sbjct: 82  RLLVNGKPVTPGQKATVSDVFELDGKRLEVAAAAEVLRRVLIYNKPEGEVTTRKDPEGRP 141

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + +P        + GRLD ++ GL++ T +G L  RL  P     + Y V++ G   
Sbjct: 142 TVFDRLPRLREHRWISIGRLDLNTTGLVMFTTDGELANRLMHPSSEIDREYAVRIFGEVD 201

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
              +E LR GVTL DG                   +       +    W  +TL EGRNR
Sbjct: 202 DAMIERLRTGVTLEDGEAK---------------FSDISAAGGTGMNRWFHVTLLEGRNR 246

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREV 215
           +VRR+    G    RL R   G   L + L  G+W E+
Sbjct: 247 EVRRLWESQGVRVSRLKRVRYGSIFLPSRLTVGKWEEL 284


>UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B6IXC3_RHOCS
          Length = 551

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 66/191 (34%), Positives = 95/191 (49%), Gaps = 17/191 (8%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEG 84
               +  PE +PTRV  ++KP  ++    DE GR T+ + +P +   V + GRLD  SEG
Sbjct: 78  VVDGQPVPEPEPTRVWRYHKPDGLVTTARDEKGRPTVFDNLPPELPRVVSVGRLDLTSEG 137

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LTN+GAL   L  P     + Y V+V G P +  +  L  G+ +      P      
Sbjct: 138 LLLLTNDGALARHLELPVTGWLRRYRVRVHGAPDEAQIAKLAQGIIIEGIEYGPIE---- 193

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                       + +R     +WL ++L EGRNR+VRR+  H+G P  RLIR A G + L
Sbjct: 194 -----------TVVDRSVGANTWLTVSLREGRNREVRRVMEHLGLPVSRLIRVAYGPFQL 242

Query: 205 DNLANGEWREV 215
             L  G+  EV
Sbjct: 243 GKLEPGQVEEV 253


>UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae RepID=Q1GFA6_SILST
          Length = 422

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 63/212 (29%), Positives = 101/212 (47%), Gaps = 19/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   +   +     + R          PE +  R+ L+ KP  ++   +DE GRKT+ +
Sbjct: 90  VNGKVIDSPALNVTNLDRI--VVDGNPLPEAEAPRLWLYYKPNGLVTTTSDEKGRKTIFD 147

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P  +  V   GRLD +SEGLL+LTN+G ++ +L  P     + Y V++ G P     +
Sbjct: 148 ALPEDLPRVMTVGRLDLNSEGLLLLTNDGGVKRQLELPSTGWLRRYRVRINGRPQDHEFD 207

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            LR GV ++     P    L               +R+    +WL I L EG+NR++RR 
Sbjct: 208 VLRKGVVIDGERFQPMTISL---------------DRQQGANAWLTIGLREGKNREIRRA 252

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
              VG+P  RL+R + G + L  L  GE  E+
Sbjct: 253 MEEVGYPVNRLLRISYGPFQLGTLKEGEVEEL 284


>UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72 RepID=A1K7C2_AZOSB
          Length = 356

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 58/183 (31%), Positives = 86/183 (46%), Gaps = 19/183 (10%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQ 95
            RV++++KP   +    D  GR T+ E +P+       A GRLD ++ GLL+ TN+G L 
Sbjct: 152 PRVLVYHKPEGEIVSRDDPEGRPTVFERLPLLRKGRWLAVGRLDFNTSGLLLFTNDGDLA 211

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
            RL  P     + Y V++ G  T++  ++L +G+ L DGP                    
Sbjct: 212 NRLMHPRYELTREYAVRLLGQLTEEQGQSLVDGIQLEDGPARFLSL-------------- 257

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWRE 214
            +         W ++TL EGRNR+VRRM   VG    RL+R   G   L   L  G W E
Sbjct: 258 -VDAGGEGVNHWYRVTLAEGRNREVRRMFEAVGLTVSRLMRVRYGPVELPARLKRGMWME 316

Query: 215 VTD 217
           + +
Sbjct: 317 LPE 319


>UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B n=117 Tax=Bacteria
           RepID=RLUB_ECO57
          Length = 290

 Score =  198 bits (503), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 63/197 (31%), Positives = 82/197 (41%), Gaps = 19/197 (9%)

Query: 23  RFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLD 79
           R      + R+   Q  RV+ + KP   L    D  GR T+ + +P        A GRLD
Sbjct: 51  RIDGHLISVRESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLD 110

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
            ++ GLL+ T +G L  RL  P +   + Y V+V G      L  L  GV L DGP    
Sbjct: 111 VNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFK 170

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
             +                        W  +TL EGRNR+VRR+   VG    RLIR   
Sbjct: 171 TIKFSGGEGI---------------NQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRY 215

Query: 200 GDYSL-DNLANGEWREV 215
           GD  L   L  G W E+
Sbjct: 216 GDIPLPKGLPRGGWTEL 232


>UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FUC8_9FIRM
          Length = 243

 Score =  198 bits (503), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 59/186 (31%), Positives = 91/186 (48%), Gaps = 19/186 (10%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFI----PVQGVYAAGRLDRDSEGLLVLTNNG 92
           Q     L NKP  +L    D    +T+ +++        ++  GRLD D+ GLL+LTNNG
Sbjct: 58  QRYHYYLLNKPEGILSATED-RHHQTVIDWLGEGYQHLDLFPVGRLDIDTTGLLLLTNNG 116

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L  +L  P K+  K Y   + G+  Q  + A   G+ L D  +LPA   ++ +      
Sbjct: 117 QLAHQLLSPKKKVDKTYTATIRGLVDQADIAAFEAGLDLGDFTSLPAELTVLSQDV---- 172

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGE 211
                       TS +++ + EG+  QV+RM   VG   L L R AMG   L+ +LA+G+
Sbjct: 173 ---------DQGTSQIQVIIQEGKFHQVKRMFQAVGKEVLSLHRLAMGPLRLESDLAHGQ 223

Query: 212 WREVTD 217
           WR +T+
Sbjct: 224 WRSLTE 229


>UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr0361 n=21
           Tax=Cyanobacteria RepID=Y361_SYNY3
          Length = 249

 Score =  198 bits (503), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 73/204 (35%), Positives = 106/204 (51%), Gaps = 25/204 (12%)

Query: 23  RFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAG 76
            F S    + K +N+P    +L NKP DVL    D  GRKT+ + +P      +G++  G
Sbjct: 47  DFLSVDGKQIKADNRPRDIYLLVNKPRDVLSTCDDPRGRKTVLDLLPQDLQRGKGLHPVG 106

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLDR+S G L+LTN+G L  RLT P     K Y V +EG P+ + LE  R+G+ L+   T
Sbjct: 107 RLDRNSTGALLLTNDGELTLRLTHPRYHLPKTYDVWLEGNPSDEDLEKWRSGMMLDGKKT 166

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
           LPA  E++ E               +     L +TL EGRNRQ+RR+   +G   L+L R
Sbjct: 167 LPATLEVISE---------------NKDQIHLLVTLTEGRNRQIRRLAEELGLTVLKLHR 211

Query: 197 YAMGDYSLDN----LANGEWREVT 216
             +G   L      L +G++R ++
Sbjct: 212 RTIGPLQLHTRGKVLGSGQFRFLS 235


>UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria RepID=Q140U9_BURXL
          Length = 633

 Score =  198 bits (503), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 62/194 (31%), Positives = 87/194 (44%), Gaps = 19/194 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEG 84
           +  +RK  ++P RV+L++KP   +    D  GR ++ + +P        A GRLD ++EG
Sbjct: 267 KPVKRKLASKPPRVLLYHKPTGEIVSHADPEGRPSVFDKLPPMKTAKWLAVGRLDFNTEG 326

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LT +G L  R   P     + Y V+V G   +   + L +GV L+DGP         
Sbjct: 327 LLMLTTSGDLANRFMHPRYSVEREYAVRVVGELAEGMRQKLLHGVELDDGPANFLRIR-- 384

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W  + L EGRNR+VRRM    G    RLIR   G  SL
Sbjct: 385 -------------DGGGEGTNHWYHVALAEGRNREVRRMFEAAGLMVSRLIRTRHGPISL 431

Query: 205 -DNLANGEWREVTD 217
              L  G W E+ D
Sbjct: 432 PKGLKRGRWEELED 445


>UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MA52_9PORP
          Length = 472

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 55/206 (26%), Positives = 89/206 (43%), Gaps = 19/206 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQ 70
            S    QV          +    +    +L NKP + +   TD  GR+T+ + +     +
Sbjct: 239 VSELGSQVLPTDQVMVDDKPVTLEAKVYVLLNKPKNCVTTLTDPEGRRTVMDLVHNACTE 298

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            +Y  GRLDR++ G+L+LTN+G L  RL  P  R  KIY V ++   T + ++ + +G  
Sbjct: 299 RIYPIGRLDRNTTGILLLTNDGDLAVRLMHPAFRKKKIYEVALDKEVTVEHMQMIAHGFE 358

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L DG         +                       + I ++ GRNR VRR+  H+G+ 
Sbjct: 359 LEDGEIHADAISYIT----------------GQTHDKVGIEIHSGRNRIVRRIFEHLGYR 402

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVT 216
            + L R      +  +L  G WR +T
Sbjct: 403 VVHLDRVYYAGLTKKDLPRGRWRYLT 428


>UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UUP0_RHOBA
          Length = 395

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 53/196 (27%), Positives = 91/196 (46%), Gaps = 16/196 (8%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDR 80
                 R        Q     + NKP  ++    D  GR  + + +P  + V+  GRLD 
Sbjct: 67  PDLQKVRVDGNYLRPQKLVYYVVNKPVGIVTTNRDPRGRPRVIDLVPPTERVFPVGRLDI 126

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAG 140
            SEGL++LTN+G L  +L  P     K+Y V V G    + ++ +R G+ + +G     G
Sbjct: 127 SSEGLILLTNDGDLAQKLAHPKFGIQKVYRVVVAGEVRGETMKKMREGIYIAEGLVQVDG 186

Query: 141 AELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
           A+++               +     + ++I L EG+NR++RR+ A  G    +L R A+G
Sbjct: 187 AKII---------------KARTKATEMEIRLKEGKNREIRRILARFGHKVQQLRRVAIG 231

Query: 201 DYSLDNLANGEWREVT 216
              L ++  G +R++T
Sbjct: 232 PLKLGDVPRGAYRKLT 247


>UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (class)
           RepID=D2B9T7_STRRD
          Length = 621

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 59/191 (30%), Positives = 86/191 (45%), Gaps = 17/191 (8%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI--PVQGVYAAGRLDRDSEGL 85
              +R P       +  NKP  V+   +D  GR +L +F+    + ++  GRLD ++EGL
Sbjct: 433 VDGKRLPTMPDLVYLAINKPIGVVSTMSDPDGRPSLADFVADRTERLFHVGRLDTETEGL 492

Query: 86  LVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVD 145
           ++LTN+G L  RLT P     K Y+ +V G   +D    L+ G+ L DG        LV 
Sbjct: 493 ILLTNDGELANRLTHPSYGVQKKYWAKVPGRIERDLGRRLKKGIELEDGIAKADSFTLVQ 552

Query: 146 EPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD 205
           E                   + +++ L+EGR   VRRM   VG P + L R   G   L 
Sbjct: 553 E---------------HGQQALVEVVLHEGRKHIVRRMLEEVGHPVIDLARIEFGPVKLG 597

Query: 206 NLANGEWREVT 216
            L  G  R +T
Sbjct: 598 RLKPGTVRALT 608


>UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1D5Q2_MYXXD
          Length = 745

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 59/212 (27%), Positives = 98/212 (46%), Gaps = 18/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++  T+ +   R        +   T   P ++ +   L  KP  V+   +D  GR T+  
Sbjct: 32  VNNKTVTELGSRVEPGTDLVTVDGTLVTPPDE-SSYFLLYKPVGVVTTLSDPQGRPTVAN 90

Query: 66  FIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
           ++    + ++  GRLD D+EG L+ T++GAL  +LT P  +  + Y  +V+G P    L+
Sbjct: 91  YVEETGKRLFPVGRLDYDAEGALLFTDDGALAHKLTHPSFQVPRTYLAKVKGAPDTATLD 150

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            LR GV L DG   P    + +                +   +WLKI + EGR   ++R+
Sbjct: 151 KLRGGVRLEDGMATPVSVSVFE---------------AAERNTWLKIVVAEGRPHLIKRL 195

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            A VG P +RL R +     ++ L  GE R +
Sbjct: 196 CAAVGHPVVRLFRPSYAGVGVEGLRPGELRPL 227


>UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1F236_ACIC5
          Length = 406

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 15/195 (7%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-----QGVYAAGRLDRD 81
           +   +     +  R  + NKP   +   +D  GR T+ EF        + +Y  GRLD  
Sbjct: 72  RVDGKLLQGPEKLRYFMLNKPKGYVTTVSDPEGRHTVMEFFHGRGKGGERLYPVGRLDYA 131

Query: 82  SEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGA 141
           SEGLL++TN+GAL   LT+      K+Y V+V G PT++ LE +R G+ ++ G   P   
Sbjct: 132 SEGLLLMTNDGALANTLTKASSHVEKVYLVKVSGRPTEEQLEQIRAGIMIDRG--RPGEG 189

Query: 142 ELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 201
            ++  PA        +R  +     W ++TL EGRNR++R+M    G    ++ R   G 
Sbjct: 190 RVMTAPA-------GVRMVRDAENPWFELTLIEGRNREIRKMFEETGHFVEKIRRIGYGP 242

Query: 202 YSLDNLANGEWREVT 216
             L ++  GE RE+ 
Sbjct: 243 LVL-DVEPGEVRELN 256


>UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrionales
           RepID=C4XSY8_DESMR
          Length = 322

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 19/219 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   R    +   +          +    +  +K   V+   +D  GR T
Sbjct: 34  RVTVNGAVVTEAGLRIDPARDALAVDGAPVNLAPEIPITLALHKKPGVVTTASDPEGRPT 93

Query: 63  LKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +P     + ++  GRLD  SEGLL+LT +G L  RLT P     K Y V V G  T
Sbjct: 94  VFDGLPEVWRGKRLFPVGRLDFFSEGLLLLTTDGELALRLTHPRWHVPKRYRVTVRGQVT 153

Query: 119 QDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
            D L  +  G+ L +G  L P  A +V+ PA                 S L++ L++G N
Sbjct: 154 PDMLGTMARGMRLAEGERLAPVAARVVEGPAQ--------------DRSILEMELHQGVN 199

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RQ+RRM   +G   LRL R + G  +L +L  G  RE+T
Sbjct: 200 RQIRRMCRDLGLTVLRLARVSQGPVALGDLPLGACRELT 238


>UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q01SF5_SOLUE
          Length = 249

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 19/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++ + + +   +   + R   +   R     +    I  NKP   +    D  GR+T
Sbjct: 29  RVTVNGSVITELGSKA-DLDRDHIKVDGRLLKAPKHQIYIALNKPKGTVTTVHDPEGRET 87

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +    + VY  GRLD  SEGLL+LTN+G L   +        K Y V+V G  T +
Sbjct: 88  VMDLLHRVKERVYPVGRLDYHSEGLLLLTNDGELANSIMSAATHLEKTYVVKVTGTLTAE 147

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             E  R GV L+   TLPAG +L+                      W ++ L EGRN Q+
Sbjct: 148 QEEKFRTGVPLSGRRTLPAGLKLLSR----------------AENPWYEVKLTEGRNNQI 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R M  H G    +L R  +G   L  L  G +R + +
Sbjct: 192 RMMFRHFGKLVEKLKRVRIGPIELGTLKTGAFRYLDE 228


>UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZE67_PLALI
          Length = 554

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 58/195 (29%), Positives = 91/195 (46%), Gaps = 17/195 (8%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDS 82
                   K   +  R  LF+KP  VL   +D AGR  + +  P     ++  GRLD  +
Sbjct: 82  QKVAVDGEKLRVEEKRYFLFHKPAGVLCTNSDPAGRTRVIDCFPPNVGRLFTVGRLDDGT 141

Query: 83  EGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAE 142
           EGLL++TN+G L  RLT P     +IY   V G P+ +A+  L  G+   +G    +   
Sbjct: 142 EGLLIVTNDGDLAERLTHPKFGIPRIYRAVVAGNPSTEAINQLLEGLYFAEGRFRMSSVN 201

Query: 143 LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
            V               +     + L+IT+ EG+NR++RR+ A VG   ++L R   G  
Sbjct: 202 RV---------------KSQGSATVLEITMREGQNREIRRLLARVGHKVMKLKRTHFGPI 246

Query: 203 SLDNLANGEWREVTD 217
            L +L  G  R++++
Sbjct: 247 KLGDLERGAHRKLSE 261


>UniRef50_P45104 Ribosomal large subunit pseudouridine synthase B n=177
           Tax=Gammaproteobacteria RepID=RLUB_HAEIN
          Length = 357

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 60/197 (30%), Positives = 82/197 (41%), Gaps = 19/197 (9%)

Query: 23  RFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLD 79
           R   Q       + +  RV+++ KP   L   +D  GR T+ + +P        A GRLD
Sbjct: 124 RIDGQIINLSHTQKEICRVLMYYKPEGELCTRSDPEGRATVFDRLPRLTGSRWIAVGRLD 183

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
            ++ GLL+ T +G L  RL  P +   + Y V+V G      L  LR GV L DG     
Sbjct: 184 INTSGLLLFTTDGELANRLMHPSREVEREYSVRVFGQVDDAMLARLRKGVQLEDGLANFK 243

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
             +                        W  +TL EGRNR+VRR+    G    RLIR   
Sbjct: 244 EIKFTGGVGI---------------NQWYDVTLMEGRNREVRRLWESQGIQVSRLIRIRY 288

Query: 200 GDYSL-DNLANGEWREV 215
           G+  L   L  G W E+
Sbjct: 289 GNIKLMKGLPRGGWEEM 305


>UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2ULL1_AKKM8
          Length = 188

 Score =  197 bits (501), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 89/177 (50%), Positives = 115/177 (64%), Gaps = 2/177 (1%)

Query: 41  VILFNKPYDVLPQFTDEA-GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ FNKPY +L QFT EA   +TL EF    GVY  GRLD DSEGLL+L++   L  RL 
Sbjct: 2   ILAFNKPYGILSQFTKEAPHHRTLAEFGFPPGVYPVGRLDADSEGLLLLSDEKGLADRLL 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALR-NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P  R  + Y+ QVEG P++  L  L   G+ +    TLP  A L+     + PR PP+R
Sbjct: 62  NPSGRHPRTYWSQVEGTPSETDLRPLELGGLRIRGHCTLPCRARLMRREPDVPPRIPPVR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            R SIPTSWL++TL EG+NRQVRRMTA +GFPTLRL+R  +G++SL  L  G W+E+
Sbjct: 122 YRASIPTSWLELTLVEGKNRQVRRMTAAIGFPTLRLLRARIGNFSLAGLKPGAWKEL 178


>UniRef50_A3HY40 Pseudouridine synthase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HY40_9SPHI
          Length = 434

 Score =  197 bits (501), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 20/207 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---Q 70
            +    +V +F       +K   +    +L NKP D +    D   RKT+   +     +
Sbjct: 235 VTELGLKVSKFDRVVYQGKKINPEKPVYVLLNKPKDFITTTDDPLERKTVMALVGNACEE 294

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            ++  GRLDR++ GLL+ TN+G L A+L+ P  +  KIY V ++   T +  + +  G+T
Sbjct: 295 RIFPVGRLDRNTTGLLLFTNDGELAAKLSHPSNQIKKIYQVTLDKPLTHNDEKDILEGLT 354

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L DG       +++                 S+    L + ++ G+NR VRR+ AH+G+ 
Sbjct: 355 LEDGEVEVDDMQVL-----------------SVDRKILGLEIHVGKNRIVRRIFAHLGYE 397

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVTD 217
              L R         +L  G +R +++
Sbjct: 398 VTALDRVMYAGLDKKDLKRGNYRFLSE 424


>UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae RepID=C6AV89_RHILS
          Length = 268

 Score =  197 bits (501), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 59/196 (30%), Positives = 91/196 (46%), Gaps = 18/196 (9%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRD 81
           +S          +    ++ NKP  ++    D  GR T+ + +    +  +   GRLD+ 
Sbjct: 70  ASISIDGLVIAAEAKIYLMLNKPRGLVTTRHDPEGRPTVYDCLRDFDIPHLSPVGRLDKA 129

Query: 82  SEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGA 141
           SEGLL+ TN+      L  P     K Y+VQ++ I   + + A+  G+  +DG  L A A
Sbjct: 130 SEGLLLFTNDTEFAQILLDPVTHVTKTYHVQIDRIMDDEDIAAMTAGIR-HDGELLTATA 188

Query: 142 ELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 201
                           R R+    SW+++ L EGRNRQ+RRM   +G   LRL+R A+G 
Sbjct: 189 --------------ARRLRQGDRNSWIEVELDEGRNRQIRRMLEALGTECLRLVRVAIGG 234

Query: 202 YSLDNLANGEWREVTD 217
             L  L  G  R +T+
Sbjct: 235 LELGELPKGAVRALTE 250


>UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B1M661_METRJ
          Length = 601

 Score =  196 bits (500), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 63/212 (29%), Positives = 99/212 (46%), Gaps = 19/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++  T+   +    +  R          P  + +R+ +F+KP  V+    D  GR+T+ +
Sbjct: 114 VNGETLTSPARNVTENDRIL--IDGEPMPSRERSRLWIFHKPRGVVTTARDPEGRQTVFD 171

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P  +  V A GRLD ++EGLL+LTN+G L   +  P     + Y V+  G   Q  L+
Sbjct: 172 VLPEDLPRVVAVGRLDINTEGLLLLTNDGGLAKVIAHPDTGWLRRYRVRAHGDTDQAQLD 231

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            L  GVT++     P  A L               +R      WL + L EG+NR+V+R+
Sbjct: 232 RLAKGVTIDGMEYGPVEATL---------------DRVQGDNVWLTLGLREGKNREVKRI 276

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
             H+G    RLIR + G + L +L  G   EV
Sbjct: 277 LEHLGLSVNRLIRLSFGPFQLGDLEVGLVEEV 308


>UniRef50_C3X1E1 Pseudouridine synthase n=2 Tax=Oxalobacter formigenes
           RepID=C3X1E1_OXAFO
          Length = 510

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 57/194 (29%), Positives = 86/194 (44%), Gaps = 19/194 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEG 84
           +  +RK      RV+ ++KP   +    D   R ++ + +P+       A GRLD ++EG
Sbjct: 224 KLIQRKIAKSLPRVLTYHKPAGEIVSRDDPEKRPSVFDRLPLLKNSKWLAVGRLDFNTEG 283

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ TN+G L  RL  P     + Y V+  G   +   + L  GV L DG          
Sbjct: 284 LLLFTNSGDLANRLMHPRYNIEREYAVRTLGELEEGMRQKLLAGVDLGDG---------- 333

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                +   +  +         W ++T+ EGRNR+VRRM   VG    RLIR   G   L
Sbjct: 334 -----IGQFSKIVDGGGEGVNKWYRVTIGEGRNREVRRMFEAVGLTVSRLIRTRYGAVVL 388

Query: 205 D-NLANGEWREVTD 217
             +L  G W E+ +
Sbjct: 389 SQSLKRGRWDELEE 402


>UniRef50_C5CXG1 Pseudouridine synthase n=4 Tax=Comamonadaceae RepID=C5CXG1_VARPS
          Length = 604

 Score =  195 bits (497), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 55/194 (28%), Positives = 83/194 (42%), Gaps = 19/194 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEG 84
           +  R +    P RVI ++KP   +    D   R T+   +P        + GRLD ++EG
Sbjct: 248 KPIRYRIAPPPPRVIAYHKPVGEVVTHDDPQNRPTVFRKLPRLQQGKWQSVGRLDLNTEG 307

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ +++G L  +L  P     + Y V+V G    +  + L  GV L+DG          
Sbjct: 308 LLLFSSSGDLANQLMHPRFGLEREYAVRVLGALNAEEKKKLLEGVRLDDG---------- 357

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                +                W ++T+ EGRNR+VRR+   VG    RLIR   G   L
Sbjct: 358 -----MAQFGTIEEGGGEGSNHWYRVTISEGRNREVRRLFESVGHAVSRLIRIRYGAMVL 412

Query: 205 -DNLANGEWREVTD 217
              L  G W E+ +
Sbjct: 413 PRGLKRGAWMELDE 426


>UniRef50_C7I043 Pseudouridine synthase n=4 Tax=Proteobacteria RepID=C7I043_THIIN
          Length = 562

 Score =  195 bits (497), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 19/192 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEG 84
           +  +R+      RV+ ++KP   +  F D  GR T+ + +P        A GRLD ++EG
Sbjct: 222 KIIKRRLRPAQARVLAYHKPTGEVVSFKDPEGRPTVFQHLPKLQGAKWTAVGRLDINTEG 281

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ T +G L  RL  P     + Y V+V G     A + L  GV L DGP      E  
Sbjct: 282 LLLFTTSGDLANRLMHPSYGAEREYAVRVLGELDAAARDELLEGVQLGDGPARFLSLE-- 339

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W ++ + EGRNR+VRRM   VG    RLIR       L
Sbjct: 340 -------------EAGGEGANRWWRVVISEGRNREVRRMFEAVGLTVSRLIRVRYASVVL 386

Query: 205 D-NLANGEWREV 215
              L  G++ E+
Sbjct: 387 PAGLRRGDFVEL 398


>UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PP04_CHIPD
          Length = 516

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 59/220 (26%), Positives = 97/220 (44%), Gaps = 23/220 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + + +F+       +     R+    +    IL NKP   +    D  GRKT
Sbjct: 305 KVTVNGELITEPAFKVTAKDEVAIN--NRKINIQKNLVYILLNKPKGYITTTDDPEGRKT 362

Query: 63  LKEFIP-----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           + E I       Q VY  GRLDR++ GLL+LTN+G L  +L  P     KIY+V +    
Sbjct: 363 VMELIQDATTEEQRVYPVGRLDRNTSGLLLLTNDGELAQKLAHPKHNIKKIYHVGLNKPL 422

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T+   E +  GVTL DG                      +   ++   + + I ++ G+N
Sbjct: 423 TKAHFENILQGVTLEDGVA----------------NVDALGYVEAGDKTQVGIEIHSGKN 466

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R VRR+  H+ +   +L R      +  N+  G+WR +T+
Sbjct: 467 RIVRRIFEHLEYEVEKLDRVTYAGLTKKNINRGKWRFLTE 506


>UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteria
           RepID=A9ITY6_BORPD
          Length = 588

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 59/192 (30%), Positives = 85/192 (44%), Gaps = 19/192 (9%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEG 84
           +   R    +P RVIL++KP   +    D  GR ++   +P        + GRLD ++EG
Sbjct: 173 KPVARPNTKKPPRVILYHKPAGEIVSHDDPGGRASVFARLPKLRTGKWLSVGRLDLNTEG 232

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+ T +G +  R+  P   T + Y V+V G       ++L  G+ L DG       + +
Sbjct: 233 LLIFTTSGDMANRIMHPRYGTEREYAVRVLGEMDDATRKSLVEGIELEDGQAAFGALDYL 292

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                                 W ++TL EGRNR+VRRM   VG    RLIR   GD  L
Sbjct: 293 GGD---------------GSNRWYRVTLQEGRNREVRRMFESVGVTVSRLIRTRFGDLVL 337

Query: 205 -DNLANGEWREV 215
              L  G W E+
Sbjct: 338 PRTLRRGRWEEL 349


>UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae RepID=A5IKF7_THEP1
          Length = 239

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 60/201 (29%), Positives = 94/201 (46%), Gaps = 19/201 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGR 77
            H V                    ILF+KP   +    D      ++   P++G++  GR
Sbjct: 38  GHSVSENDVVVLDGETVNFHRKVYILFHKPSGYVTSTKDPHSETIMEFLPPLKGIFPVGR 97

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD+D+EGLL++T++G    R+  P     K Y V+VEG  T+D +E L+NGVTL DG   
Sbjct: 98  LDKDAEGLLIITSDGDFAHRVISPKWSVEKEYIVKVEGEVTEDKIEKLKNGVTLRDGFFA 157

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
            A                     + +    LKI + EG+  Q++RMT  VG  T+ L R 
Sbjct: 158 KAKC------------------VEKLSNDTLKIVITEGKYHQIKRMTVAVGLRTVHLKRT 199

Query: 198 AMGDYSL-DNLANGEWREVTD 217
            +G   L +++  GE+R +++
Sbjct: 200 RIGRLVLPEDMKPGEYRFLSE 220


>UniRef50_Q2W4E4 Pseudouridine synthase n=20 Tax=cellular organisms
           RepID=Q2W4E4_MAGSA
          Length = 247

 Score =  195 bits (496), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 24/198 (12%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVY------AAGRL 78
              R      +  P  V++ +KP       +D    + + E +P + ++        GRL
Sbjct: 58  DDIRVDGEPLDPPPGLVLMLHKPEGYTCSTSDPG--RIVYELLPERFMHRNPIVAPVGRL 115

Query: 79  DRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLP 138
           DRDS GLL+LT++G L  R+T P +   K Y V +    + +      +G  +    + P
Sbjct: 116 DRDSTGLLLLTDDGPLAHRITSPKRHVPKTYEVTLARPLSGEEGAVFASGTLMLRSESTP 175

Query: 139 AGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYA 198
                   PA L    P             +IT+ EGR  QV+RM A VG    RL R A
Sbjct: 176 LA------PAELVVSGPQTA----------RITITEGRYHQVKRMFAAVGNHVERLHRAA 219

Query: 199 MGDYSLDNLANGEWREVT 216
           +G   L +LA G+WR ++
Sbjct: 220 IGGLDLGDLAEGQWRPLS 237


>UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MIA1_RHOM4
          Length = 268

 Score =  195 bits (496), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 63/201 (31%), Positives = 90/201 (44%), Gaps = 23/201 (11%)

Query: 22  KRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-----GVYAAG 76
                    R  P+ Q    IL NKP+D +    DE GR+T+ + I +      G++  G
Sbjct: 53  DDIVEVNGVRVVPQTQ-ALYILMNKPHDTITTCDDERGRRTVLDLINLPPEQKNGLFPVG 111

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLDR++ G+L+LTN+G L  RL  P  R  KIY  +       +  E LR GV L DGP 
Sbjct: 112 RLDRNTTGVLLLTNDGELANRLMHPRYRVEKIYVARTARPVKPEEAEQLRRGVQLEDGPA 171

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
                 +                        + + +YEGRNRQVRRM   +G   ++L R
Sbjct: 172 RAVQVAV-----------------NPADPHEIALMIYEGRNRQVRRMLEAIGHEVVQLKR 214

Query: 197 YAMGDYSLDNLANGEWREVTD 217
                 +   +  G+WR +TD
Sbjct: 215 THYAGLTTKGVRPGKWRRLTD 235


>UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales RepID=C5WHE9_STRDG
          Length = 245

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 21/220 (9%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++++        + ++ K   +     +    +     + NKP   L    D   + 
Sbjct: 27  KAILVNQEVETSPKVQINEHKDVVT--YLGKPLTYEAFVYYILNKPAGFLSATKD-RAQA 83

Query: 62  TLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + +      + V+  GRLD+D+ GLL+LTNNG L   L  P K   K Y  +V GI 
Sbjct: 84  TVIDLLDETARQKDVFPVGRLDKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIM 143

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T    +    G++L D   LPA  E++D+               S  T  + IT+ EG+ 
Sbjct: 144 TDADKDDFAKGISLKDHQCLPAKLEVLDKDL-------------SQETCVVSITIQEGKF 190

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            QV+RM A  G   L L R +MG   LD  LA G++R +T
Sbjct: 191 HQVKRMVAACGKEVLELQRLSMGPLRLDPGLAEGDFRRLT 230


>UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine synthase A n=3
           Tax=Fusobacterium RepID=UPI0001BC42E2
          Length = 235

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 26/219 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           R+  ++   +        + K         +K   Q  R  + +K    +    D     
Sbjct: 25  RKIRVNGLFITSPKENIEEEK--DEVYYGEKKLSYQEFRYYILHKKAGYVTALEDSRE-A 81

Query: 62  TLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + +P     + +   GRLD+D+EGLL+ TN+G L  RL  P     K Y+  +E   
Sbjct: 82  TVMDLLPEWVIKKDLAPVGRLDKDTEGLLLFTNDGKLNHRLLSPKSHVDKTYHASLECDI 141

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T++ALE LR GV + +  TLPA AE +++                     + +T+ EG+ 
Sbjct: 142 TEEALEKLREGVMIGEYKTLPAKAEKLED-------------------RKIALTIREGKF 182

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            QV++M   VG   + L R + G   L +L  GE +EV+
Sbjct: 183 HQVKKMLEAVGNKVIYLKRISFGKLVLGDLELGEVKEVS 221


>UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MIA3_BDEBA
          Length = 265

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 64/211 (30%), Positives = 97/211 (45%), Gaps = 15/211 (7%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQP---TRVILFNKPYDVLPQFTDEAGRKTLKEFIP 68
           ++      +V   S +     KP  +P       + NKP  VL    D   R T+ E++ 
Sbjct: 12  KRVYELGIKVDPQSDRILVDGKPLRKPLTQKIYAILNKPTGVLTTMDDPHDRPTVAEYLT 71

Query: 69  VQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALR 126
                V+  GRLD DSEG+L+LTN+G    ++  P     K Y V++ G P    LE L+
Sbjct: 72  ELPVRVFPVGRLDWDSEGMLLLTNDGDFANKVMHPKAEVTKTYLVKLNGKPEPFQLEKLK 131

Query: 127 NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
            GV++  G       E + +            + KS    W KI + EG+NRQ+R+M A 
Sbjct: 132 KGVSIVGGKVSARHIEKIKKTG----------DNKSEKYEWYKIVITEGKNRQIRQMFAK 181

Query: 187 VGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +GF  +RL R A+G   +  +  GE   + D
Sbjct: 182 IGFDVMRLQRVAIGRLRMGAVKTGELVYLND 212


>UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EVQ2_DICNV
          Length = 266

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 58/206 (28%), Positives = 92/206 (44%), Gaps = 14/206 (6%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---G 71
               ++      +          P  +++++KP   +    D  GR ++ + +P      
Sbjct: 47  KISGNERLSLDGKPLRIAVEHKNPHMILMYHKPAGEICTRKDPEGRVSVFQHLPKISHGR 106

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
             A GRLD ++ GLL+ TN+GAL  +L  P     + Y+V+V G  T++ L ALR G+ L
Sbjct: 107 WVAIGRLDLNTSGLLLFTNDGALANQLMHPSAEIEREYWVRVAGEVTEEMLTALRQGIPL 166

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
           +DG                      + E  +    +  +TL EGRNR+VRR+   VG   
Sbjct: 167 DDGLARFTEI----------CPLKTLHEDDTQFNRYFSVTLKEGRNREVRRLWEAVGCKV 216

Query: 192 LRLIRYAMGDYSL-DNLANGEWREVT 216
            RL R   G  SL  +L+ G  R +T
Sbjct: 217 SRLKRIRYGTISLPPSLSAGRHRLLT 242


>UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytoplasma
           RepID=Q2NIZ3_AYWBP
          Length = 245

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 14/204 (6%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI---PVQG 71
           S    +V          +          L NKP   L    D+  R T+ + I    +Q 
Sbjct: 36  SELGTKVSSSDIITLDDKPITKATYSYFLLNKPNGFLSTAKDKKNRPTVLDLIEEASIQR 95

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +Y  GRLD ++ GLL++TN+G L  +LT P     K Y+V++     +  L     G+ +
Sbjct: 96  LYPIGRLDFNTTGLLLITNDGDLTQKLTHPSFCIPKEYHVKINACLQKKDLSTFCKGIII 155

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
           +           + + +++             P++WLK+ + EG+NRQVR+M   +G+  
Sbjct: 156 DKKYLAVCKEIDILKISYMP-----------KPSTWLKLVITEGKNRQVRKMMQALGYQV 204

Query: 192 LRLIRYAMGDYSLDNLANGEWREV 215
           L+L RY     +++NL  G +R +
Sbjct: 205 LKLKRYRYSFLTIENLTIGAYRPL 228


>UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IJT7_ACIBL
          Length = 680

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 63/221 (28%), Positives = 99/221 (44%), Gaps = 11/221 (4%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++ N   K    +         R   +  + +    +L +KP   +   +D  GR+T+ +
Sbjct: 30  VTVNGEVKNELGSKADPETDDIRVDGKPLKAEQLVYVLLHKPKGYVTTVSDPEGRETVMD 89

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +      +Y  GRLD  SEGLL+LTN+G + A+LT       K Y V+V G PT++ ++
Sbjct: 90  LVKGIPARLYPVGRLDYLSEGLLLLTNDGEMAAKLTHASTHVPKKYLVKVSGEPTEEQIQ 149

Query: 124 ALRNGVTL--NDGPTLPAGAE------LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
            LRNGV L    G       E             +      I   +     W ++TL EG
Sbjct: 150 ELRNGVQLPPEQGHIHADPREGGRFGGEKRRSTAVKTAPCKIELTREGDNPWYEVTLNEG 209

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RNRQ+RRM   +G    ++ R   G   L ++ NGE+R + 
Sbjct: 210 RNRQIRRMFDFIGHHVEKIKRVEYGPLKL-DVENGEFRLLN 249


>UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacteria
           RepID=B7L142_METC4
          Length = 674

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 62/215 (28%), Positives = 99/215 (46%), Gaps = 19/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +   +       R +        P  + TR+ L +KP  V+    D  GR T
Sbjct: 47  RVTLNGKVLTSPAINVTDSDRIT--VDDEPLPARERTRLWLLHKPRGVVTTARDPEGRPT 104

Query: 63  LKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P +   V A GRLD ++EGLL+LTN+G L   +  P     + Y V+  G  TQ 
Sbjct: 105 VFDGLPEELPRVVAIGRLDINTEGLLLLTNDGGLAKVIAHPDTGWLRRYRVRAFGDVTQP 164

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ L+ G+T++     P  A L               +R      WL + L EG+NR+V
Sbjct: 165 DLDKLKKGLTVDGMEYGPIEATL---------------DRAQGDNVWLTLGLREGKNREV 209

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +R+  H+G    RLIR + G + L +L  G   E+
Sbjct: 210 KRILEHLGLSVNRLIRLSFGPFQLGDLEVGLVEEI 244


>UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium RepID=A5TWE7_FUSNP
          Length = 234

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 61/207 (29%), Positives = 105/207 (50%), Gaps = 19/207 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPE---NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV- 69
           T+     +    +     +K +   N+     + NKP +VL   +D+ GRKT+ + I   
Sbjct: 33  TATTGMDINENDNIFIDGKKIKTSINEEKVYFMLNKPLEVLSSSSDDRGRKTVVDLIKTD 92

Query: 70  QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV 129
           + ++  GRLD  + GL++LTN+G L  R+  P     K YY+++ G   ++ ++ L+ GV
Sbjct: 93  KRIFPIGRLDYMTSGLILLTNDGELFNRVVHPKSEIYKKYYIKILGELKKEEIDELKKGV 152

Query: 130 TLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGF 189
            L+DG TLPA    +               +     + + I++ EGRNRQ+RRM     +
Sbjct: 153 LLDDGKTLPAKISGI---------------KYDKNKTSMFISIREGRNRQIRRMIEKFEY 197

Query: 190 PTLRLIRYAMGDYSLDNLANGEWREVT 216
             L L R  +G+ +L +L  G++RE+T
Sbjct: 198 KVLMLRREKIGELALGDLPEGKYRELT 224


>UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U325_9PROT
          Length = 387

 Score =  193 bits (492), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 61/204 (29%), Positives = 92/204 (45%), Gaps = 17/204 (8%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QG 71
           TS   +           +  PE +P R+  ++KP  ++    D  GR T+ + +P     
Sbjct: 43  TSPAVNVDDDSVILVDEKPLPEIEPPRLWRYHKPDGLVTSNRDPEGRSTVFDRLPKDLPR 102

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           V   GRLD DSEGLL+LTN+G L   L  P     + Y V+V G   +  L+ L+ GV +
Sbjct: 103 VVTVGRLDIDSEGLLLLTNDGGLARYLELPSTGWVRRYRVRVFGPLDEAKLDNLKKGVRI 162

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
                 P    +               ++ +   SWL + L EG+NR++RR+  HVG   
Sbjct: 163 EGVEYGPIEVTI---------------DKATRTNSWLTVALREGKNREIRRVMEHVGLTV 207

Query: 192 LRLIRYAMGDYSLDNLANGEWREV 215
            RLIR   G + L  +  G   E+
Sbjct: 208 SRLIRTTYGPFQLGEVPPGGVEEI 231


>UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZI67_9SPHI
          Length = 391

 Score =  193 bits (492), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 56/206 (27%), Positives = 99/206 (48%), Gaps = 20/206 (9%)

Query: 15  SFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QG 71
           +    QV    + +  +R  + +    +L NKP D +    D   RKT+ + I     + 
Sbjct: 193 TEMGFQVSPTDTVKYGKRLLKREKFVYVLLNKPKDFITTTNDPQDRKTVMDLIKNSCDER 252

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +Y  GRLDR++ GLL+ TN+G +  +L+ P     K+Y V+++     + L+++  GV L
Sbjct: 253 IYPVGRLDRNTTGLLLFTNDGEVAKKLSHPSHDVKKVYQVELDKPLKDEDLDSIAEGVIL 312

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
            DG         VDE A L P             + + + ++ GRNR VRR+  H+ +  
Sbjct: 313 EDGYAA------VDEIAILNPER-----------TLVGVEIHIGRNRIVRRIFNHLDYEV 355

Query: 192 LRLIRYAMGDYSLDNLANGEWREVTD 217
           ++L R      +  N+  G+WR +++
Sbjct: 356 VKLDRTMYAGLNKKNIDRGDWRYLSE 381


>UniRef50_Q4FV02 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q4FV02_PSYA2
          Length = 208

 Score =  193 bits (492), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 97/186 (52%), Positives = 124/186 (66%), Gaps = 14/186 (7%)

Query: 41  VILFNKPYDVLPQFTDEAG--RKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
           +ILFNKPY V  QF D++     TL E+   + +  AGRLD  SEGLL+LT++G +   +
Sbjct: 6   LILFNKPYGVQSQFRDDSNNDHTTLSEYFTDKSLRIAGRLDATSEGLLILTSDGRINKAI 65

Query: 99  TQP---------GKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDE--- 146
           TQP          ++ GK Y VQVEG+ T   L+ L +GV L DG TLPA A L+DE   
Sbjct: 66  TQPPSAKNFAQNKQKQGKTYLVQVEGVVTAVQLKELASGVILKDGKTLPASATLLDEADL 125

Query: 147 PAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN 206
           P  LW R+PPIRERK+IPTSWL +T+YEG+NRQVRRMTAHVG P LRLIR+++  + L  
Sbjct: 126 PITLWQRDPPIRERKNIPTSWLMLTIYEGKNRQVRRMTAHVGLPCLRLIRWSVAGFELGE 185

Query: 207 LANGEW 212
           L  GE+
Sbjct: 186 LGVGEF 191


>UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6G735_9DELT
          Length = 300

 Score =  193 bits (492), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 105/216 (48%), Gaps = 20/216 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFT---DEAGRKT 62
           ++   +++   R    +   + R    + E++     + NKP  V+       DE GR T
Sbjct: 59  VNGQVVRELGTRVFPERDRVTVRGEPIQAESK--VYYVLNKPDGVVSSAAGSVDERGRPT 116

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +   +    + +Y  GRLD  S G+L+LTN+G L   LT P     K Y+V+ +G  T++
Sbjct: 117 VISLLHGVSERLYPVGRLDFHSRGVLLLTNDGGLAEALTHPRHGVVKTYHVKFQGKLTEE 176

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             + LR+GV L+DG             A   P       R++    W +I + EG NRQ+
Sbjct: 177 QEQLLRDGVELDDG-------------AITRPVAELFAFRETATNVWYQIGIREGLNRQI 223

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   +G P L+LIR A+GD + D +  GE+R + 
Sbjct: 224 RRMGEAIGHPVLKLIRVAIGDITADGVPEGEFRALN 259


>UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus RepID=Q49YI4_STAS1
          Length = 232

 Score =  193 bits (491), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 25/219 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q  I +        + +        +   +K +      ++ NKP D +   TDE   K
Sbjct: 25  KQVTIDDKVETSPKKQIN--PELEIVKVNDQKIDFVNKVYLMLNKPKDYISATTDEQ-HK 81

Query: 62  TLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + I       ++  GRLD+D+EGLL++TN+G     L  PGK   K Y V  +   T
Sbjct: 82  TVLDLIEDYRYLDLFPVGRLDKDTEGLLLITNDGQFNHELMSPGKHVAKTYEVISQKNIT 141

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++ + A + G+ LN+G   PA     DE    +                  +T+YEGR  
Sbjct: 142 KNDINAFKVGIELNEGLAKPAKLVQGDELNKSF------------------VTIYEGRYH 183

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QV+RM   +    L L R  +GD  LD  LA+GE+R +T
Sbjct: 184 QVKRMFHAIDNEVLALKRIRIGDLQLDSTLASGEYRHLT 222


>UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus RepID=Q1J642_STRPF
          Length = 244

 Score =  193 bits (490), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 65/203 (32%), Positives = 94/203 (46%), Gaps = 20/203 (9%)

Query: 20  QVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP----VQGVYA 74
            +  +    + +  P   +     L NKP   +    D   + T+ E +      + V+ 
Sbjct: 41  HIDEYKDLVTYQGTPLVYESFVYYLLNKPSGYVSATQDRQ-QATVMELLDDTARQKTVFP 99

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
            GRLD+D+ GLL+LTNNG L   L  P K   K Y  +V GI T+   +    G++L D 
Sbjct: 100 VGRLDKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIMTEADKDYFARGISLKDH 159

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
             LPA  E++                    TS +KIT+ EG+  QV+RM A  G   L L
Sbjct: 160 QCLPAHLEVLASDL-------------QQQTSLVKITIQEGKFHQVKRMVAACGKEVLDL 206

Query: 195 IRYAMGDYSLD-NLANGEWREVT 216
            R +MG   LD +LA GE+R +T
Sbjct: 207 QRLSMGPLKLDPSLAEGEFRRLT 229


>UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID=C1XV14_9DEIN
          Length = 369

 Score =  192 bits (489), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 63/191 (32%), Positives = 90/191 (47%), Gaps = 22/191 (11%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSEGLL 86
               R    +   VI  +KP  V    +D    +T+ + +P V G++  GRLD+DSEGLL
Sbjct: 48  LDGERVRLPEKKVVIALHKPVGVTTTKSDPHAERTVYQLVPDVPGLHPVGRLDKDSEGLL 107

Query: 87  VLTNNGALQARLTQPGKRTGKIYYVQVE-GIPTQDALEALRNGVTLNDGPTLPAGAELVD 145
           +LTN+G L  +LT P     K+Y    + G  ++     L  GV L+DG      AE   
Sbjct: 108 LLTNDGDLTLKLTHPRYGVRKVYRAWCKHGRVSEADCRRLVEGVALDDGLAQALEAEPTQ 167

Query: 146 EPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD 205
           E A                    +I + EG+ R+VRRM   +G+P  RL+R  +G   L 
Sbjct: 168 EGA--------------------RIVMAEGKKREVRRMLGRLGYPVTRLVRLQVGPIKLG 207

Query: 206 NLANGEWREVT 216
            L  GEWR +T
Sbjct: 208 KLNPGEWRYLT 218


>UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ATCC 33270
           RepID=A8SLU4_9FIRM
          Length = 230

 Score =  192 bits (489), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 58/206 (28%), Positives = 93/206 (45%), Gaps = 19/206 (9%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQ 70
           K + +   +          +K + +   +  L NKP         +   K + + I   +
Sbjct: 32  KLATKGIDISENDEVLVEGKKIKLEEAKKYYLLNKPIGYSSTAKAQFQEKIVLDLIDSKE 91

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            +Y  GRLD+DS GLL+LTN+G L  RLT P     K Y V+V+    +  L+ L +G+ 
Sbjct: 92  RIYPVGRLDKDSFGLLLLTNDGDLAFRLTHPSHNVEKEYIVKVDKTLKESDLKKLSSGIM 151

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L    T  A  E++D                   ++ +K+ L EGRNRQ+R+M   + + 
Sbjct: 152 LEGKITRKARFEMLD-----------------FKSNIVKVFLKEGRNRQIRKMFKTLDYN 194

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVT 216
            + L R A G   L  L  G +RE++
Sbjct: 195 VISLERIAFGKIKLGKLKVGNYRELS 220


>UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R7V9_9PLAN
          Length = 811

 Score =  192 bits (489), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 62/204 (30%), Positives = 98/204 (48%), Gaps = 17/204 (8%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRKTLKEFIPV-QG 71
            +    +V           +   +P R   + NKP  V+    D+AGR  + + +P  + 
Sbjct: 67  VTELGTRVDPVKQTIRVDGEALRKPQRLYFVVNKPEGVVTTNYDQAGRTRVIDLVPTDER 126

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           V+A GRLDR SEGL+++TN+G    R+T P     K Y V+V G  +   L  LR G+ L
Sbjct: 127 VFAVGRLDRASEGLIIVTNDGEFANRVTHPRYGVTKTYLVRVAGEASTAELAKLRRGIHL 186

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
           +DG       ++               +R+   ++ + I L EG+NR++RR+ A +G   
Sbjct: 187 SDGFCKVDAIQV---------------KRRHKQSTDMVIQLSEGKNREIRRILARIGHKV 231

Query: 192 LRLIRYAMGDYSLDNLANGEWREV 215
           L+L R A+G   L  L  G WR +
Sbjct: 232 LKLKRLAVGSLKLGELPLGAWRWL 255


>UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterineae
           RepID=A4QE19_CORGB
          Length = 320

 Score =  192 bits (488), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 66/213 (30%), Positives = 93/213 (43%), Gaps = 25/213 (11%)

Query: 10  TMQKTSFR-NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP 68
           T Q      N+ V R    R       N+     + NKP  +    +DE GR  + + + 
Sbjct: 114 TTQGVRVNPNNDVIRVDGVRIH----INEDLEYFVLNKPRGMHSTMSDELGRPCVGDLVS 169

Query: 69  V-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
                 Q ++  GRLD D+EGLL+LTN+G L  RL  P     K Y   V G  T   + 
Sbjct: 170 EKTASGQRLFHVGRLDADTEGLLLLTNDGELANRLMHPKYEVSKTYLATVRGEATNKLVS 229

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
           ALR+GV L DGP     A+++D                    S L+I ++EGR   VRR+
Sbjct: 230 ALRDGVELEDGPAKADFAQIID---------------VFQGKSLLRIEIHEGRKHIVRRL 274

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              +GFP  RL+R  +    L +   G  R + 
Sbjct: 275 FDELGFPVERLVRTKLHTVQLGDQKPGSLRALN 307


>UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID=B7L2Z9_METC4
          Length = 320

 Score =  192 bits (488), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 65/192 (33%), Positives = 93/192 (48%), Gaps = 18/192 (9%)

Query: 29  STRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGV---YAAGRLDRDSEGL 85
              R+  +     +L NKP  +L  + D  GRKT+ + +    +      GRLD  SEGL
Sbjct: 74  VDGRRLVSAAKVYLLLNKPRGLLTTYGDPQGRKTVYDCLAGHDLPFLAPVGRLDCASEGL 133

Query: 86  LVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVD 145
           L++TN+     RL  P     K+Y+VQ++  P +  L  LR GV  +DG  L A      
Sbjct: 134 LLMTNDTRWAHRLLDPASNVDKVYHVQIDRRPDEALLTGLREGVA-HDGERLAAK----- 187

Query: 146 EPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD 205
                         R     +WL++ L EGRNRQ+RRM A  G   LRL+R A+G   L 
Sbjct: 188 ---------SVAPLRVGERNAWLEVVLSEGRNRQIRRMMALNGAEVLRLVRVAVGGVRLG 238

Query: 206 NLANGEWREVTD 217
           ++  G +R +TD
Sbjct: 239 DVRKGAFRHLTD 250


>UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria RepID=Q3MC44_ANAVT
          Length = 288

 Score =  192 bits (488), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 68/216 (31%), Positives = 100/216 (46%), Gaps = 28/216 (12%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ- 70
           QK +     +       S +R   +     +L NKP  V+    D  GRKT+ + +P + 
Sbjct: 66  QKVNPERDIITVDGKSVSAQR---HHRLTYLLLNKPTGVVSTCYDPQGRKTVLDLLPEEL 122

Query: 71  ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALR 126
               G++  GRLD  S G L+LTN+G L  +LT P     K Y + V+G P +  L+  R
Sbjct: 123 RKGSGLHPVGRLDAYSTGALILTNDGDLTFKLTHPSHNIPKTYQILVKGHPPEAVLKMWR 182

Query: 127 NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
            GV L+   T  A   L++  A                 S L+I L EGRNRQ+RR+   
Sbjct: 183 EGVLLDGRKTRKAKVSLLESLAE---------------KSRLEIVLQEGRNRQIRRVAEQ 227

Query: 187 VGFPTLRLIRYAMGDYSLDN-----LANGEWREVTD 217
           +G+P ++L R A+G   L       L  G +R + D
Sbjct: 228 LGYPVIKLHRTAIGSIQLQTSKQPLLRAGNYRILRD 263


>UniRef50_C6X4T2 Pseudouridine synthase n=2 Tax=Flavobacteriaceae RepID=C6X4T2_FLAB3
          Length = 371

 Score =  191 bits (487), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 51/207 (24%), Positives = 89/207 (42%), Gaps = 19/207 (9%)

Query: 14  TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--- 70
            +   +QV++        +    +    +L NKP   +    DE  RKT+ + +      
Sbjct: 172 VTEMGYQVQKTDKVIFDGQGITPEKPVYVLLNKPKGYISTTKDEKARKTVMDLVANASPY 231

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            V+  GRLDR + G+++LTN+G +  +LT P     KIY+V ++    +  L A+  GV 
Sbjct: 232 RVFPVGRLDRSTTGVILLTNDGHMTKKLTHPSFNMKKIYHVTLDRKLDRADLNAIAEGVR 291

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           L +G         +                +  P + + I ++ G NR VRR+   +G+ 
Sbjct: 292 LEEGVAEVDSISYI----------------EGKPKNEVGIEIHIGWNRVVRRIFQRLGYE 335

Query: 191 TLRLIRYAMGDYSLDNLANGEWREVTD 217
              L R      +  N+  G WR +T+
Sbjct: 336 VEALDRVMFAGLTKKNIKRGHWRILTE 362


>UniRef50_A9KPL1 Pseudouridine synthase n=63 Tax=Bacteria RepID=A9KPL1_CLOPH
          Length = 477

 Score =  191 bits (487), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 59/217 (27%), Positives = 93/217 (42%), Gaps = 24/217 (11%)

Query: 5   IISENTMQKTSFRNHQVKRFSSQRSTRRKPE---NQPTRVILFNKPYDVLPQFTDEAGRK 61
           I                K    Q+    K E    +   +I F+KP  ++   T++    
Sbjct: 40  IAKGEVTIDGEVAVMGSKVLPGQKVVLGKKEVSREEKMVLIAFHKPKGIVCT-TEKREPD 98

Query: 62  TLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + ++I   Q +Y  GRLD+DSEGL+ LTNNG +  ++ + G    K Y V V    T  
Sbjct: 99  NIIDYIKYSQRIYPIGRLDKDSEGLIFLTNNGDIVNKILRAGNHHEKEYIVTVNKPITAA 158

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ +  GV + D  T P   E +D+                      +I L +G NRQ+
Sbjct: 159 FLKGMAGGVPILDTVTKPCTLEAIDKV-------------------TFRIILTQGLNRQI 199

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RRM  H  +   +L+R  + + +L  L  G +R +TD
Sbjct: 200 RRMCEHFDYKVTKLVRIRIMNVNLGRLKVGGYRNLTD 236


>UniRef50_B4D966 Pseudouridine synthase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4D966_9BACT
          Length = 237

 Score =  191 bits (487), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 93/216 (43%), Gaps = 24/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  I+   +   S +   V    + +   R    +    +L NKP   +   +DE  RKT
Sbjct: 26  QVRINGQVVTDLSTQ---VGPTDAVKVGSRLLRTEQKITVLLNKPAGYVCTASDERDRKT 82

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P     VY  GRLD+DSEGLL++TN+G L   LT P  +  K Y V ++      
Sbjct: 83  IFDLLPANWPRVYHVGRLDKDSEGLLLVTNDGDLSLALTHPRYKIEKEYEVLLDKPFNPQ 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             E L  G  +  G       E+++                    + L +TL +G  RQ+
Sbjct: 143 DREKLLKGFHIIGGRAKAERVEILNP-------------------THLSLTLTQGIKRQI 183

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R M   +G+   RL R  +G   +  +  GEWR +T
Sbjct: 184 RLMLYDLGYEVERLARIRLGPLKIGEMRPGEWRLLT 219


>UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3ESK0_9BACT
          Length = 616

 Score =  191 bits (487), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 70/209 (33%), Positives = 102/209 (48%), Gaps = 20/209 (9%)

Query: 10  TMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV 69
           T+  T       +     ++   +PE     + LF KP  ++    D   + TLK+F P 
Sbjct: 52  TVPGTKVHPETDRVTVDGKTVPVEPE---PFLFLFYKPKGIVSTLHDPDEKTTLKDFFPQ 108

Query: 70  QG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNG 128
              +   GRLD  SEG+L+LTNNG L  R+  P     + Y V+V+G+   + L+ LR+G
Sbjct: 109 INPLIHVGRLDIQSEGVLLLTNNGDLAQRILHPRYEIPRTYLVKVQGVVKPEHLDRLRSG 168

Query: 129 -VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
            V L+  P  P   E               +ER +   SW +ITL EGRNR+VRR+   +
Sbjct: 169 KVRLDGRPVQPLELE---------------QERLTETNSWYRITLTEGRNREVRRLFDAL 213

Query: 188 GFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            +  L+L R A G+  L  L  GE+R VT
Sbjct: 214 HYFVLKLTRIAFGNLDLAGLEPGEYRLVT 242


>UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LSY4_SYNAS
          Length = 251

 Score =  191 bits (486), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 60/198 (30%), Positives = 90/198 (45%), Gaps = 17/198 (8%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGR 77
            ++R   +   +     +    ++ NKP   +   +D   R  +   +P  G  ++  GR
Sbjct: 44  DIERDEIRVDGKLICAEETKVYVMLNKPRGYVTALSDPQKRPLVIHLLPELGVRLFPVGR 103

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD DSEGLL+LTN+G    R+  P  R  K Y V++ G         L+ G+ L DG   
Sbjct: 104 LDYDSEGLLLLTNDGGFAQRVQHPRYRISKTYRVKISGRLNAAEFNRLQKGLELEDGKFA 163

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           P    L               E  +  +SWL + + EGRNR +RR    +G   LRLIR 
Sbjct: 164 PDEVAL---------------EEINPKSSWLTMKISEGRNRVIRRAFEQLGHEVLRLIRT 208

Query: 198 AMGDYSLDNLANGEWREV 215
           A+ D  L NL  G++R +
Sbjct: 209 AVADLHLGNLREGDYRLL 226


>UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZC3_ERYRH
          Length = 246

 Score =  191 bits (486), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 55/205 (26%), Positives = 95/205 (46%), Gaps = 15/205 (7%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRKTLKEFIPVQ- 70
           K + +  +V               +  +   + NKP  ++    D+  R+++ + +P   
Sbjct: 39  KVTEQGLKVSTEDRVMVNGILINVEEKKVYYILNKPRGIVSSANDDKDRESVVDLVPNDI 98

Query: 71  GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVT 130
            V+  GRLDR++ G L+LTN+G     +T P     KIY V V G  + +   +L+ G+T
Sbjct: 99  RVFPVGRLDRETTGALILTNDGDFAYYMTHPKFDLSKIYRVSVRGRLSYEVTNSLKEGIT 158

Query: 131 LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
           +            V             +   +   +   ITL+EG+NRQ+R++ AH G P
Sbjct: 159 IEGVEYKGVEISRV-------------KYDAAKDKTQFSITLHEGKNRQIRKIFAHFGLP 205

Query: 191 TLRLIRYAMGDYSLDNLANGEWREV 215
            L+L RY +G   +D L  G++RE+
Sbjct: 206 VLKLHRYQIGYLDIDELKIGQYREL 230


>UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID=B2TQQ1_CLOBB
          Length = 264

 Score =  191 bits (486), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 55/220 (25%), Positives = 103/220 (46%), Gaps = 12/220 (5%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   + + S   ++  +        +K  +      +FNKP   +    D   R T+ +
Sbjct: 29  VNGEIITEPSIDINE--KLDDVEYLEKKVVHTGKVYYMFNKPSGCITATKDNIHR-TVFD 85

Query: 66  FIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
           +      GV+  GRLD+D+EGLL+LTN+G  + ++  P K   K Y+    G    +  +
Sbjct: 86  YFDEDMNGVFHVGRLDKDTEGLLLLTNDGEFEHKVMHPEKHVEKTYFFWALGSLDDEDKK 145

Query: 124 ALRNGVTL--NDGPTLPAGAELVDEPAWLWPRNP----PIRERKSIPTSWLKITLYEGRN 177
            L+ GV +  N+  T PA  ++    +++  +       ++ +   P     +T+ EG+ 
Sbjct: 146 QLQEGVFIGSNEALTKPAKIDIHKSGSYIEFKEEIPINSLKNKDHQPVVSGYLTISEGQK 205

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
            QV+RM   VG   + L R ++G   LD  L  G++R++T
Sbjct: 206 HQVKRMLKAVGCYVIYLKRISIGGLKLDESLKMGDYRDLT 245


>UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2G3_SALRD
          Length = 249

 Score =  191 bits (485), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 21/200 (10%)

Query: 21  VKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-----GVYAA 75
           V+   +      +        +L NKP D +    D   R+T+ + I V      G++  
Sbjct: 51  VREGQTVTVDGEEVYPLEFEYLLLNKPKDTISTTDDPKDRRTVLDAIGVPEDNPSGLFPV 110

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP 135
           GRLDR++ G+L+++N+G L  RL  P     KIYYV+V+       L+ L+ GV L+DG 
Sbjct: 111 GRLDRNTTGVLLVSNDGDLAHRLMHPRYEIPKIYYVRVQDDVKPHQLDQLKRGVELSDGA 170

Query: 136 TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLI 195
                   +D                    + + + L+EGRNRQ+RRM   +G   ++L 
Sbjct: 171 AAADQVAYLD----------------PQRKTDIALELHEGRNRQIRRMMEALGHTIVQLE 214

Query: 196 RYAMGDYSLDNLANGEWREV 215
           R      +   L  GEWR +
Sbjct: 215 RAKYATLTTGRLQRGEWRRL 234


>UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae RepID=B3QY10_CHLT3
          Length = 297

 Score =  191 bits (485), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 65/222 (29%), Positives = 101/222 (45%), Gaps = 26/222 (11%)

Query: 3   QFIISENTMQKTSF---RNHQVKRFSSQRSTRRKP--ENQPTRVILFNKPYDVLPQFTDE 57
           + I     M          ++V R + +     K   EN     IL NKP DV+   +DE
Sbjct: 62  EMIEQGEVMVNGKVVMELGYKVDRRADEVVVNGKKLHENTQKIYILLNKPKDVVTTSSDE 121

Query: 58  AGRKTLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
             RKT+ E + ++  V+  GRLDRD+ G+L+LTN+G L  RLT P     K Y   ++  
Sbjct: 122 KSRKTVVELVGLKDRVFPVGRLDRDTTGVLLLTNDGDLTYRLTHPTFGVQKQYVATLDKK 181

Query: 117 PTQDALEALRNGVTLND--GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
            T   L+ ++ G  L D      P  A ++D+   +W                  + ++E
Sbjct: 182 ITSVDLQNIKKGFRLKDTGEKVSPCNARILDDGYTIW------------------VAIHE 223

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           G+N Q+ RM    G+   +L+R A G   +  +  GEWR +T
Sbjct: 224 GKNHQIHRMFWSFGYNVKKLVRVAYGGLEVGTMRRGEWRFLT 265


>UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracellularis PHE/MN1-00
           RepID=Q1MQ05_LAWIP
          Length = 270

 Score =  191 bits (485), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 69/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRF--SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +  I+  ++ +     H  K       R    + +N+    +   KP  V+    D   R
Sbjct: 49  EVTINGKSVTQPGIYIHPDKDIIALHGRRVDIQLKNKKYYYLSMYKPIKVISSVKDPQNR 108

Query: 61  KTLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
            T+ +FIP       +Y  GRLD  SEGLL++TN+G L  RLT P     K+Y+V +   
Sbjct: 109 LTVLDFIPFPWKNYRLYPVGRLDFFSEGLLLITNDGELTQRLTHPRYHISKVYHVLIRER 168

Query: 117 PTQDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
                L+ +  G+TL+DG  L PA   ++                    T+WL+ITL +G
Sbjct: 169 ILNTTLKNISKGITLSDGTKLPPAKVRVLSSIT-------------ETNTTWLEITLQQG 215

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            NRQ+RRM   +G   L+LIR   G+ +L NL  GE R +
Sbjct: 216 INRQIRRMCKELGLTILKLIRVKQGNINLSNLQPGEVRPL 255


>UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IR68_ACIBL
          Length = 254

 Score =  191 bits (485), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 62/178 (34%), Positives = 90/178 (50%), Gaps = 17/178 (9%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARL 98
             + NKP  ++   +DE GR+T+   +P     V   GRLD+ SEGLL+LTN+    A++
Sbjct: 74  YYVVNKPRGLITTASDEKGRETIYSLLPPDSPWVAPVGRLDKASEGLLLLTNDSEWAAKI 133

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K Y+VQV  +P++  +EAL  G+  +    L     ++              
Sbjct: 134 TDPNSHLDKTYHVQVSTLPSEQMVEALSRGIRSDGELLLAKRVSIL-------------- 179

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            R      WL+I L EG+NRQ+RRM A +    LRLIR A+G  +L  L  G  R +T
Sbjct: 180 -RAGGKNGWLEIVLEEGKNRQIRRMVAALQIEVLRLIRVAIGPLTLGELPKGGCRALT 236


>UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus RepID=B5ELL5_ACIF5
          Length = 268

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 62/192 (32%), Positives = 86/192 (44%), Gaps = 16/192 (8%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRLDRDSE 83
              R           +V+L +KP  VL    DE GR T+ + +P    +   GRLD+ S 
Sbjct: 69  PGIRIDGLDITASTRQVLLLHKPRGVLTTRQDERGRATVYDLLPGSPWLAPVGRLDQASS 128

Query: 84  GLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAEL 143
           GLL+ +N+     RL  P +   K Y+VQ+    + D +  L     L+  P LP     
Sbjct: 129 GLLLFSNDPHWAQRLLDPDQHVAKTYHVQIRPPLSTDTVVQLAADSVLDGEPCLPMQIRE 188

Query: 144 VDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYS 203
           +               R    T WL+  L EGRNRQ+RR+ A      LRLIR A+G+  
Sbjct: 189 L---------------RCGGKTQWLEFILQEGRNRQIRRLLAACDREVLRLIRVAVGNLP 233

Query: 204 LDNLANGEWREV 215
           L  L  GEWR +
Sbjct: 234 LGELRAGEWRWL 245


>UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vaginalis
           RepID=D2RB61_GARVA
          Length = 284

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 63/211 (29%), Positives = 93/211 (44%), Gaps = 31/211 (14%)

Query: 22  KRFSSQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI- 67
               +   TR  P+ Q  RV             +  +KP  VL    D  GR TL++ + 
Sbjct: 76  DELVTTLGTRVDPKRQKVRVDGSRVKFNTKLVTLALHKPKRVLSAMDDPKGRFTLRDIVG 135

Query: 68  -PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL- 125
              + ++  GRLD DSEGL+++TN+G L   +  P     K Y   VEG         L 
Sbjct: 136 DKYERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATVEGKINGMVCRRLV 195

Query: 126 RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTA 185
             GV L DG        ++D               ++  T+ +KI L+ G+NR VRR+  
Sbjct: 196 SQGVNLEDGWIKLDRCAIID---------------QNHDTTMVKIVLHSGKNRIVRRIFG 240

Query: 186 HVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            VGFP  RL+R  +G   L +L  G +R ++
Sbjct: 241 AVGFPVKRLVRTQIGPIKLGDLKAGSYRVLS 271


>UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus marinus
           RepID=Q7VBH8_PROMA
          Length = 237

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 65/188 (34%), Positives = 105/188 (55%), Gaps = 19/188 (10%)

Query: 34  PEN-QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLT 89
           P+N + ++VIL NKP  V+    D  GRKT+ + +P    +G++  GRLD+DS G L+++
Sbjct: 57  PKNIKSSKVILLNKPTGVISTCRDTHGRKTVLDLLPDNLQKGMHPVGRLDKDSRGALIIS 116

Query: 90  NNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAW 149
           NNG L   LT P     K Y V + G+P+++ L+  RNG+ ++   T  A   +V     
Sbjct: 117 NNGLLTLHLTHPRFNHKKRYSVLITGVPSKNTLKKWRNGIEIDKKTTRKALVNIV----- 171

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
                     ++    + L+I L+EGRNRQ+R++   +G P + LIR  +G+  L+ L  
Sbjct: 172 ----------KRQGNNTLLEIVLFEGRNRQIRKVADKLGHPVIDLIRIEIGNIKLNGLKE 221

Query: 210 GEWREVTD 217
           G WRE+ +
Sbjct: 222 GAWREINE 229


>UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID=Q6G8H4_STAAS
          Length = 231

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 98/221 (44%), Gaps = 24/221 (10%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +++ +++ N     S + H               E      I+ NKP D +    D    
Sbjct: 22  LKKGLVNVNEQVIKSPKTHIEPENDKITVRGELIEYIENVYIMLNKPKDYISATED-HHS 80

Query: 61  KTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           KT+ + IP      ++  GRLD+D+EGLL++TN+G     L  P K   K Y V      
Sbjct: 81  KTVIDLIPEYQHLNIFTVGRLDKDTEGLLLITNDGDFNHELMSPNKHVSKKYEVISANPI 140

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T+D ++A + GVTL+DG   PA    +D                        +T+YEG+ 
Sbjct: 141 TEDDIQAFKEGVTLSDGKVKPAILTYIDNQTS-------------------HVTIYEGKY 181

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
            QV+RM   +    L L R  + D  LD NL +GE+R +T+
Sbjct: 182 HQVKRMFHSIQNEVLHLRRIKIADLELDSNLDSGEYRLLTE 222


>UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0LG91_HALO1
          Length = 553

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 70/215 (32%), Positives = 97/215 (45%), Gaps = 17/215 (7%)

Query: 5   IISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLK 64
           ++S N  + T      V               +    +L NKP   L   TD   R T+ 
Sbjct: 30  VVSVNGQRVTELGTKVVPGRDRVSVRGEAVYPEEPFYVLLNKPKGCLTAVTDPENRPTVM 89

Query: 65  EFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
           E++      V   GRLD  SEG+L+LTN+G L ARL  P     K Y+V+V    T+  L
Sbjct: 90  EYLHGLPARVVPVGRLDFYSEGVLLLTNDGDLSARLQSPRHHVEKTYHVKVRDQVTERHL 149

Query: 123 EALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           E LR GV L DG  T PA  +++                      WL ITL EG++RQ+ 
Sbjct: 150 EVLRQGVRLEDGTVTRPAQIDMLG--------------GTKSRHDWLVITLTEGKSRQIH 195

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RM   +G+  ++L R A G  +   L  G+ RE+T
Sbjct: 196 RMLGVLGYTVMKLQRVAFGGLTFHGLRVGDARELT 230


>UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae RepID=B4RA72_PHEZH
          Length = 521

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 62/183 (33%), Positives = 92/183 (50%), Gaps = 13/183 (7%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           E +P RV  ++KP  ++    D  GR T+ E +P  +  + + GRLD +SEGLL+LTN+G
Sbjct: 206 EPEPVRVFRYHKPVGLVTTHKDPQGRPTVFEALPEGLPRLISVGRLDLNSEGLLLLTNDG 265

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L   L  P     + Y  +  G  TQ+ L+ L++G+T+         A L         
Sbjct: 266 GLARALELPATGVVRRYRARAHGRITQERLDTLKDGITVEGVRYGAIEARL--------- 316

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                +E       WL +TL EG+NR+VRR+   +G    RLIR + G ++L  L  GE 
Sbjct: 317 --DKAKEGHQGANLWLTVTLQEGKNREVRRVLEALGLKVNRLIRLSYGPFALGTLDVGEI 374

Query: 213 REV 215
            EV
Sbjct: 375 EEV 377


>UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=Q1J0B9_DEIGD
          Length = 253

 Score =  190 bits (483), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 68/199 (34%), Positives = 88/199 (44%), Gaps = 23/199 (11%)

Query: 21  VKRFSSQRSTRRKPEN--QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGR 77
           V      R   R  E   Q +   L  KP   +    DE GR+ +   +P   G++  GR
Sbjct: 45  VMPDDEVRVDGRLIEAPAQESVTFLLYKPAGYVTTARDEYGRRNVLSAMPPIPGLHPVGR 104

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD+DSEGLL+LT +G L   LT P     K Y     G P    L  L  G+ L DGP  
Sbjct: 105 LDKDSEGLLLLTTDGQLTLTLTHPRYGHEKAYRAWTAGQPVAAELRVLETGIELADGPAR 164

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
              A      A                     +TL EGRNRQVRRM   +G+P  RL+RY
Sbjct: 165 ALSARPARGGAL--------------------VTLTEGRNRQVRRMLDAIGYPVHRLLRY 204

Query: 198 AMGDYSLDNLANGEWREVT 216
            +G   L +L  GE+R ++
Sbjct: 205 RVGGLWLGDLEPGEYRLLS 223


>UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q31GA0_THICR
          Length = 317

 Score =  190 bits (483), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 64/198 (32%), Positives = 96/198 (48%), Gaps = 16/198 (8%)

Query: 23  RFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAGRLD 79
           + + Q     + E QPT+VIL+NKP   +    DE GR+T+   +P        + GRLD
Sbjct: 64  KVNDQLVKETRLEKQPTQVILYNKPEGQVCSRKDEKGRETIFTSLPRIINSRWISVGRLD 123

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
            ++ GLL+LTNNG L  RL  P     + Y V+V G  + + L+ L+ GV L DG     
Sbjct: 124 INTSGLLILTNNGELANRLMHPSYEMEREYSVRVFGEVSDEILDRLKKGVKLEDGFAKFE 183

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
               + +            + +     W ++ + EGRNR+VRR+    G    RL+R   
Sbjct: 184 SIGKIPQ------------QEEDSINQWYRVVIKEGRNREVRRIWESQGVQVSRLVRTRY 231

Query: 200 GDYSL-DNLANGEWREVT 216
           G +SL  NL  G+   +T
Sbjct: 232 GQFSLPRNLRRGKSEPLT 249


>UniRef50_Q9HZ55 Ribosomal large subunit pseudouridine synthase B n=67
           Tax=Gammaproteobacteria RepID=RLUB_PSEAE
          Length = 386

 Score =  189 bits (482), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 58/204 (28%), Positives = 83/204 (40%), Gaps = 18/204 (8%)

Query: 16  FRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---V 72
             +H           R +      RV+++NKP   +    D  GR T+ + +P       
Sbjct: 53  VDSHDAITVDGHLIRREEAAESVRRVLIYNKPEGEVCTRDDPEGRPTIFDRLPRLRTGRW 112

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
              GRLD ++ GLL+ T +G L  RL  P     + Y V+V G  T++ +E L NGV L 
Sbjct: 113 INVGRLDINTTGLLLFTTDGELANRLMHPSYEMDREYAVRVRGEVTEEMIERLLNGVMLE 172

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
           DGP   +  +                        W    + EGRNR+VRR+    G    
Sbjct: 173 DGPAKFSDIQQAPGGEGF--------------NHWYHCVVMEGRNREVRRLWESQGLVVS 218

Query: 193 RLIRYAMGDYSL-DNLANGEWREV 215
           RL R   G   L   L  G +RE+
Sbjct: 219 RLKRVRFGPVFLTSELTMGRYREM 242


>UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R892_9RHOB
          Length = 681

 Score =  189 bits (482), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 63/212 (29%), Positives = 102/212 (48%), Gaps = 19/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++ N +   +F   Q  +       +  P  + TR+ LF+KP   +    D  GRKT+ +
Sbjct: 65  VNGNVLDTPAFTVTQKDKV--YVDGKPLPTRERTRLWLFHKPRGTVTTNKDPEGRKTVFD 122

Query: 66  FIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P     V   GRLD ++EGLL+LTN+G L   +  P     + Y V+  G  TQ+ L+
Sbjct: 123 ILPKDMPRVVTVGRLDINTEGLLLLTNDGGLSRVIELPATGWLRRYRVRAFGKVTQEQLD 182

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
           AL++GV ++                 L+       + +     WL I L EG+NR+V+R+
Sbjct: 183 ALKDGVAIDG---------------VLYGAIEATLDTEKGDNVWLTIGLREGKNREVKRI 227

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
             H+     RLIR + G + L +L  GE +E+
Sbjct: 228 LEHLDLSVNRLIRISFGPFQLGDLGEGELQEI 259


>UniRef50_C1DA59 Pseudouridine synthase n=6 Tax=Betaproteobacteria
           RepID=C1DA59_LARHH
          Length = 703

 Score =  189 bits (482), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 61/199 (30%), Positives = 97/199 (48%), Gaps = 18/199 (9%)

Query: 23  RFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLD 79
           R  S+    R P+  P RVI+++K    +    D  GR T+ + +P        A GRLD
Sbjct: 499 RVDSKPVLIRWPDRLP-RVIVYHKQEGEIVTRDDPEGRTTVFDRLPQTRSSKWVAIGRLD 557

Query: 80  RDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPA 139
            ++ GLL+ T +G L  R+T P     + Y V+V G  T + ++    GV L+DG   PA
Sbjct: 558 VNTSGLLIFTTSGDLANRMTHPSFEVEREYAVRVLGKLTPEQMKETTAGVQLDDG---PA 614

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
             + + E            +++     W ++ + EGRNR+VRRM  H G    RL+R   
Sbjct: 615 SFQFIREDD----------DKEDSVNHWYRVGIREGRNREVRRMFEHFGLTVSRLMRVRF 664

Query: 200 GDYSLDN-LANGEWREVTD 217
           G  +L + L  G++ E+ +
Sbjct: 665 GIVTLPSRLKRGQFYELNE 683


>UniRef50_UPI0001C37AA4 16s pseudouridylate synthase n=2 Tax=Ruminococcus flavefaciens FD-1
           RepID=UPI0001C37AA4
          Length = 255

 Score =  189 bits (482), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 56/216 (25%), Positives = 92/216 (42%), Gaps = 32/216 (14%)

Query: 14  TSFRNHQVKRFSSQRSTR--------RKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
            +     VKR  ++  T             ++  R IL NKP   +    D+ G +T+ +
Sbjct: 30  VTVNGSPVKRSDTKIDTGADDVTVCGNAISSERFRYILLNKPKGYVSSTDDKDG-ETVIK 88

Query: 66  FIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +P +    G++ AGRLD+DS G L++T++GAL  R+  P     KIY  ++     Q+ 
Sbjct: 89  LVPPEMRSKGLFPAGRLDKDSTGALLITDDGALAHRICSPNNHISKIYAAELSRPFEQEY 148

Query: 122 LEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           +E    G+ L +G    P   +  +    L                   + L+EG   QV
Sbjct: 149 VEKFAKGIVLANGEACSPCKVQKAENADNLAF-----------------VELHEGMYHQV 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           +RM A VG     L R ++G   L  +L  G+   +
Sbjct: 192 KRMFAAVGNHVENLKRISIGGLILPKDLPLGKCMYL 227


>UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodictyon group
           RepID=Q3B289_PELLD
          Length = 250

 Score =  189 bits (482), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 61/187 (32%), Positives = 96/187 (51%), Gaps = 22/187 (11%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNN 91
           +PE +    ILFNKP +V+   +DE  R+ + +FI V + VY  GRLDR + G+L+LTN+
Sbjct: 69  QPEGRKI-YILFNKPRNVITTSSDERNREMVLDFIDVNERVYPVGRLDRKTTGVLLLTND 127

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND--GPTLPAGAELVDEPAW 149
           G L  +L  P     K Y   ++    Q +L  L  G+ L+D      P  A+++ + + 
Sbjct: 128 GMLANKLMHPSSNVKKEYIAVLDAPFPQASLPLLTGGMRLSDTGEKVSPCQAKIMGDGSQ 187

Query: 150 LWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLAN 209
           +W                  I+++EG+N QVRRM   +GF   RL R      ++ +L  
Sbjct: 188 VW------------------ISIHEGKNHQVRRMFKTLGFEVTRLDRPTYAGLTVGDLRR 229

Query: 210 GEWREVT 216
           G+WR +T
Sbjct: 230 GQWRHLT 236


>UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5SLZ5_THET8
          Length = 243

 Score =  189 bits (481), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 18/206 (8%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG 71
           Q       +V   ++     R  E +    +L +KP   +   T+      L +  P + 
Sbjct: 35  QVVKDPGFRVPEGAALEVEGRPLEVRRHLHVLLHKPPGFVTSRTEGPSVYALLQGFPTRD 94

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           +   GRLD+D+EGLL+ T +G L  RLT P  +  K Y V +E        EA R G+ L
Sbjct: 95  LSPVGRLDKDAEGLLLFTTDGLLLHRLTHPRHKVAKRYLVHLERPVGPKDQEAFREGILL 154

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
           +   TLPA    +++P                  +W ++ L EGR  Q++RM    G   
Sbjct: 155 DGKKTLPAELTPLEDP------------------TWAEVVLKEGRFHQIKRMFRARGNRV 196

Query: 192 LRLIRYAMGDYSLDNLANGEWREVTD 217
           LRL R A+G   L +L  G+ R +T+
Sbjct: 197 LRLKRLALGPLELGDLPPGKARPLTE 222


>UniRef50_B2V6W2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B2V6W2_SULSY
          Length = 244

 Score =  189 bits (481), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 26/220 (11%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           +++  ++  S+  H             +   +     + NKP   +    DE    T+ +
Sbjct: 29  VNDEIVKDPSY--HIDPMKDKVELEDEEILYKENHYFMLNKPAGYITATEDEE-YPTVLD 85

Query: 66  FIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ-D 120
                     ++  GRLD D+EGLL+LT +G    RL+ P     K YY  VEG  +  D
Sbjct: 86  LFSDLPIASKLFPVGRLDIDTEGLLILTTDGQFGHRLSHPKWNIEKEYYAIVEGDISNID 145

Query: 121 ALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
             E+   G+ L      T P   ++++                S   S + ITL EG+  
Sbjct: 146 FSESENKGIYLKKEKYQTKPFKVKVLN---------------TSKDKSEILITLTEGKYH 190

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
            V+R+   +G+P L L R  +G+  LD +L  GE+RE+T+
Sbjct: 191 IVKRIMQELGYPVLYLKRIRIGNLKLDEDLLPGEFRELTE 230


>UniRef50_C3BQR1 Pseudouridine synthase n=3 Tax=Bacillus RepID=C3BQR1_9BACI
          Length = 203

 Score =  189 bits (481), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 51/184 (27%), Positives = 83/184 (45%), Gaps = 19/184 (10%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNG 92
           + E++    I F+KP  +     D      ++     + ++  GRLD+ SEGL++LTN+G
Sbjct: 28  EKEDKEKIYIAFHKPVGITCTAADHIDGNIIEYINHPERIFPVGRLDKASEGLILLTNDG 87

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            +  ++        K Y V V+   T   ++ +  GV + DG T       V+       
Sbjct: 88  RIANQILHGDYEHEKEYIVTVDKPFTDWFIDGMSRGVKIKDGITKQCKVTRVN------- 140

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                       +S  +I L +G NRQ+RRM+   G+   +L R  + +  LD L  GEW
Sbjct: 141 ------------SSTFRIILTQGMNRQIRRMSRAFGYTVTKLKRVRIMNIKLDGLEAGEW 188

Query: 213 REVT 216
           R VT
Sbjct: 189 RNVT 192


>UniRef50_Q9I5J6 Ribosomal small subunit pseudouridine synthase A n=25
           Tax=Gammaproteobacteria RepID=RSUA_PSEAE
          Length = 230

 Score =  189 bits (480), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 65/206 (31%), Positives = 92/206 (44%), Gaps = 27/206 (13%)

Query: 18  NHQVKRFSS-QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVY 73
            H+V+ FS  +   R     +P R  + +KP   +    D     T+ +  P      ++
Sbjct: 38  THEVRVFSRVELDERLLQAGKPARYYMLHKPMGCVSATRDPQ-HPTVLDLFPEDLRDDLH 96

Query: 74  AAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGV--TL 131
             GRLD ++ GL++LTN+G    RLT PG R  K+YYV+ E    Q  ++A   G+    
Sbjct: 97  IGGRLDYNTTGLMLLTNDGQWSRRLTLPGSRRDKVYYVETEAPIDQRYVDAFAAGLHFRF 156

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
            D  TLPA  E +                        ++TL+EGR  QV+RM  H     
Sbjct: 157 EDLVTLPAQLEPIGPRCA-------------------RLTLHEGRYHQVKRMFGHFDNKV 197

Query: 192 LRLIRYAMGDYSLD-NLANGEWREVT 216
           LRL R  MGD  LD  L  G WR + 
Sbjct: 198 LRLHRERMGDICLDPQLPPGAWRPLN 223


>UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum variabile DSM 15176
           RepID=D1PIW4_9FIRM
          Length = 237

 Score =  189 bits (480), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 24/186 (12%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFI----PVQGVYAAGRLDRDSEGLLVLTNNG 92
           Q    I+ NKP  V+    D+    T+ + +    P + ++ AGRLD+ S G ++LT++G
Sbjct: 60  QKYVYIMLNKPEGVVSASRDKRD-TTVVDLVAADFPRRALFPAGRLDKTSTGFVLLTDDG 118

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-PAGAELVDEPAWLW 151
           AL   L  P     K Y V ++   T         GVTL DG T+ PA AE   E   + 
Sbjct: 119 ALAHDLLSPAHHVDKQYLVTLDTPLTDAMRAGFAAGVTLADGETMAPAEAEPAGEDPCV- 177

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANG 210
                           +K+TL++G   Q++RM    G     L RYA+G  +LD  LA G
Sbjct: 178 ----------------VKVTLHQGVYHQIKRMFGVYGAGVNALHRYAIGGVALDAALAPG 221

Query: 211 EWREVT 216
           +WRE+T
Sbjct: 222 QWRELT 227


>UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales RepID=B1C6T1_9FIRM
          Length = 238

 Score =  189 bits (480), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 55/216 (25%), Positives = 95/216 (43%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +++     +  K        +    +      + NKP  V+     + G +T
Sbjct: 30  KVTVNGEVVRELGTIINVEKDLVKV-YGKEVSLDTKKVYYMLNKPQGVISASKSKYGEET 88

Query: 63  LKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      ++  GRLD+D+ GL++LTN+G    +LT P     K Y   V+G     
Sbjct: 89  VVDLLGKKEHRLFPVGRLDKDTTGLIILTNDGDFAYKLTHPKYEKEKTYEALVKGKVDSK 148

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           +L+ L+ GV ++   T  A   LV                     S ++ITL EGR RQV
Sbjct: 149 SLDKLKQGVVIDGKKTSRAKVRLVKMIGV---------------NSLVEITLIEGRKRQV 193

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++M   VG   ++L R      SL +L  GE+R++T
Sbjct: 194 KKMCEKVGHKVIKLNRTMENGLSLGDLEIGEYRKLT 229


>UniRef50_Q2NSN0 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q2NSN0_SODGM
          Length = 235

 Score =  188 bits (479), Expect = 9e-47,   Method: Composition-based stats.
 Identities = 60/224 (26%), Positives = 93/224 (41%), Gaps = 34/224 (15%)

Query: 2   RQFIISENTMQKTSFR---NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEA 58
           ++  +    +++ +F+    HQV+ F      +        R  + NKP   +    D  
Sbjct: 25  KRVTVDGEIIKQGAFQLRPEHQVR-FDGNLLHQILTA----RYFMLNKPQGYVCSTDDP- 78

Query: 59  GRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
              T+  FI       ++AAGRLD D+ GL++LT++G    RLT P     K Y V +E 
Sbjct: 79  DHPTILYFIDEPVPDKLHAAGRLDIDTTGLVLLTDDGQWSYRLTSPRHHCEKDYLVTLEQ 138

Query: 116 IPTQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
               +       G+ L     PT PA    +                       +++T+ 
Sbjct: 139 PLAAEITAQFAAGILLRGEKLPTRPARLATLSPL-------------------KVRLTIS 179

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
           EGR  QV+RM A VG   + L R  +G   LD  L  GE+R +T
Sbjct: 180 EGRYHQVKRMFAAVGNRVVALHRERIGAIVLDAHLQPGEYRALT 223


>UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=A1UU09_BARBK
          Length = 499

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 54/184 (29%), Positives = 89/184 (48%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNN 91
           P  + TR+ L++KP  ++    D  GR T+ + +P +   V + GRLD ++EGLL+LTN+
Sbjct: 99  PPIERTRLWLYHKPSGLVTTNRDPEGRPTVFDNLPKEMPRVVSVGRLDINTEGLLLLTND 158

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   L  P     + Y V+  G   Q  L+ L+NG+ ++                  +
Sbjct: 159 GGLARVLELPLTGWVRKYRVRAHGKIKQSELDKLKNGIAIDG---------------IFY 203

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  +R+     WL + L EG+NR+++     +G    RLIR + G + L +L  G 
Sbjct: 204 GSIDASIDREQGSNVWLSVALREGKNREIKNFLGALGLSVNRLIRVSYGPFQLSDLEEGA 263

Query: 212 WREV 215
            RE+
Sbjct: 264 VREL 267


>UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus Y51MC23
           RepID=B7A9J5_THEAQ
          Length = 245

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 58/199 (29%), Positives = 89/199 (44%), Gaps = 18/199 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGR 77
              V   ++     R    +    +L +KP   +    +      L E  P + +   GR
Sbjct: 50  GFHVPEGAALEVEGRPLAVRRHLHLLLHKPAGYVTSRKEGPSVYALLEGFPTRDLSPVGR 109

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD+D+EGLL+ T +G L  RLT P  +  K Y V +    T   + A + G+ L+   TL
Sbjct: 110 LDKDTEGLLLFTTDGELLHRLTHPRHKVEKRYLVHLLHPATAADVRAFQEGILLSGEKTL 169

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           PA   L ++P                  +W+++TL EGR  QV+RM    G   L L R 
Sbjct: 170 PARLHLGEDP------------------TWVELTLLEGRFHQVKRMFQARGNQVLYLKRL 211

Query: 198 AMGDYSLDNLANGEWREVT 216
           A+G  +L++L  G  R +T
Sbjct: 212 ALGPLTLEDLPLGAARPLT 230


>UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XS61_9BACT
          Length = 235

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 17/183 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGAL 94
           +    +  NKP   +    D+  RK + + +P +   +Y+ GRLD DSEGL+ LTN+G  
Sbjct: 59  KRKLYVALNKPRGYVCSRKDDRKRKVIGDLLPAEWDNLYSVGRLDSDSEGLIFLTNDGEF 118

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              LT P  R  K Y   VEG   Q+ L+  ++G+           A  +          
Sbjct: 119 SLHLTHPRYRVLKKYLATVEGRVEQEMLQRFKHGIVHEGEKLKVDRARTLS--------- 169

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
                     TS +++ L EG+NR++RR+    G    RL+R  +G   L  L +G+WR 
Sbjct: 170 ------VQNSTSLVELELTEGKNREIRRLFESQGLTVSRLVRMQIGKIKLGELRSGKWRM 223

Query: 215 VTD 217
           +T+
Sbjct: 224 LTE 226


>UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=B9MRL6_ANATD
          Length = 233

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 24/218 (11%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +R+ I++ N  Q                   R  +      I+ NKP   +    + A  
Sbjct: 22  IREGIVTVNGKQIVEVDFKINPEEDIIEVDGRVAKFSKQIYIMMNKPKGYVCSNEELASL 81

Query: 61  KT---LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
                + + +  + ++  GRLD+D+EGLL++T++G    R+  P KR  K Y V++E   
Sbjct: 82  TVFSLISDDLKYRDLHTVGRLDKDAEGLLIITDDGEYTHRVISPKKRIEKEYLVRLEKEV 141

Query: 118 TQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            ++ L    NG+ L+DG  TLPA   ++D                   ++ +K+ +YEG+
Sbjct: 142 DEEKLNEFENGIILDDGYKTLPAKYTIID-------------------STTVKLCIYEGK 182

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWR 213
             QV+RM   +G   + L R  +G  +LD +L  GE+R
Sbjct: 183 YHQVKRMFEAIGNKVVDLKRLRIGGLNLDQSLKPGEYR 220


>UniRef50_C9LMF3 Ribosomal small subunit pseudouridine synthase A n=1 Tax=Dialister
           invisus DSM 15470 RepID=C9LMF3_9FIRM
          Length = 277

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 51/224 (22%), Positives = 96/224 (42%), Gaps = 18/224 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGRKTLK 64
           ++   +    F  ++    + +     +P         + NKP  V+    D   +KT+ 
Sbjct: 46  VNGEKITDPGFMVNE----NDEIIFAGEPVPYFRYEYYMLNKPAGVITATED-RYQKTVL 100

Query: 65  EFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           +F   +    +   GRLD+D+ GLL++TN+G    RL  P K   K YY +++G   +  
Sbjct: 101 DFFGERRRKDLSPVGRLDKDTVGLLLVTNDGGFHHRLLSPKKHIDKEYYARIDGRVDEAD 160

Query: 122 LEALRNGVTLNDGPT-LPAGAEL-------VDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
            E    G+ +++  T LPA   +       ++        +   +       S +++ + 
Sbjct: 161 REKFEKGIYVDEIFTALPAKLMIDGYRENALESDFMDLANSRAPKSALENGVSEIRVVVQ 220

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           EG+  Q++RM   +G   + L R  +G   LD  L  G +R +T
Sbjct: 221 EGKFHQIKRMFHALGKEVIYLKRIRIGSVVLDPTLEEGTYRRLT 264


>UniRef50_A5TW76 Pseudouridine synthase n=11 Tax=Fusobacterium RepID=A5TW76_FUSNP
          Length = 226

 Score =  188 bits (478), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 24/215 (11%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           I+ N     S +++  +          K E +  R  + NK    +    D     T+ +
Sbjct: 27  ITVNGFNDISAKDNIDENSDIIEYNGEKLEYKEFRYYIMNKKAGYITATED-FKENTVMD 85

Query: 66  FIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +P     + +   GRLD+D+EGLL+ TN+G L  RL  P     K+YY+++E       
Sbjct: 86  LLPEWVIRKDLAPVGRLDKDTEGLLLFTNDGKLNHRLLSPKNHIDKVYYIEIENNILDKD 145

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +  L  GV + +  T PA  E + +                   + + +T+ EG+  QV+
Sbjct: 146 ILKLEQGVDIGNYITQPAKVEKISD-------------------NKIYLTIKEGKFHQVK 186

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +M   V      L R + G   LD+LA GE +EV 
Sbjct: 187 KMLEAVNNKVCYLKRVSFGKLKLDDLALGEVKEVN 221


>UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacteria
           RepID=Q0G3T3_9RHIZ
          Length = 639

 Score =  188 bits (478), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 61/191 (31%), Positives = 96/191 (50%), Gaps = 17/191 (8%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEG 84
           +      P+ + TR+ LF+KP   +    D  GR+T+ + +P  +  V + GRLD ++EG
Sbjct: 231 EVDGALLPQAERTRLWLFHKPAGTVTTNKDPEGRRTVFDMLPEDMPRVLSIGRLDINTEG 290

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LTN+G L   L  P     + Y V+  G  TQ  L+ LRNG++++        A L 
Sbjct: 291 LLLLTNDGGLSRVLELPSTGWLRRYRVRAHGSITQAKLDELRNGISVDGVFYGAIEATL- 349

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                         +R+     W+ + L EG+NR+V+ +   +G    RLIR + G + L
Sbjct: 350 --------------DREQGSNVWITLGLREGKNREVKNVLGALGLEVNRLIRLSYGPFQL 395

Query: 205 DNLANGEWREV 215
            +LA G  REV
Sbjct: 396 GDLAEGSVREV 406


>UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HYA4_9BACT
          Length = 638

 Score =  188 bits (478), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 102/216 (47%), Gaps = 24/216 (11%)

Query: 6   ISENTMQKTSFRN---HQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +    + +   R    HQV     +      P    T + LF KP  V+    D  GR T
Sbjct: 54  VDGEVVTEPGTRVDPKHQVILVDGRPL----PREPETFLFLFYKPKGVVSTLFDPEGRPT 109

Query: 63  LKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           L+++ P    +   GRLD  +EG L+LTNNG L  R+  P     + Y V+++G  +   
Sbjct: 110 LRDYFPGIDPLLHIGRLDFQTEGALLLTNNGDLSQRILHPRFEIPRTYLVKIQGGMSPAH 169

Query: 122 LEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           LE +  G + L+  P +P                  + ER++   +W +ITL EGRNR+V
Sbjct: 170 LERMARGEIRLDGRPVVPLEL---------------VPERQTSTNAWYRITLTEGRNREV 214

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RR+   + +  L+L+R A G  +L  L  GE+R VT
Sbjct: 215 RRLFETLNYFVLKLVRTAFGPLTLAGLEPGEYRTVT 250


>UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actinobacterium
           RepID=D0U645_9ACTN
          Length = 237

 Score =  188 bits (477), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 58/181 (32%), Positives = 86/181 (47%), Gaps = 21/181 (11%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQA 96
              +  +KP  VL    D  GR +L +FI    + ++  GRLD+DSEGL++LTN+G L  
Sbjct: 64  KSYLALHKPKGVLSTMFDPEGRPSLDDFIDLRKERLFHVGRLDKDSEGLILLTNDGDLTF 123

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPP 156
           R T P     K Y ++ +GI      + L  GV L DG                      
Sbjct: 124 RATHPSFGLEKTYIIEFDGILPTGVDKVLLKGVELEDGM-------------------GR 164

Query: 157 IRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +   K +   W++++++EGR   +RR+   VG   LRLIR   G  SL +   G WR++ 
Sbjct: 165 VLTFKQLSPKWIEVSIHEGRYHIIRRLMEAVGVNVLRLIRTKFGPISLGDTPEGRWRDLN 224

Query: 217 D 217
           D
Sbjct: 225 D 225


>UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BMY5_9LACT
          Length = 237

 Score =  188 bits (477), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 63/225 (28%), Positives = 101/225 (44%), Gaps = 25/225 (11%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRST----RRKPENQPTRVILFNKPYDVLPQFTD 56
           M++ I S   +  ++   H       Q         + E+   +  L NKP  V+   TD
Sbjct: 18  MKKLISSGEVLIDSTPATHVSNNVDPQIQVITVQGSRMEDNSQKYYLLNKPKGVITATTD 77

Query: 57  EAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQV 113
                T+ +      ++G+Y  GRLDRD+EGLL++TNNG L  RL  P +   K YYV+V
Sbjct: 78  SQL-PTVIDLFKNENIEGLYPIGRLDRDTEGLLIITNNGPLGYRLLNPIQHIEKEYYVEV 136

Query: 114 EGIPTQDALEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
            G      ++   +G+  +DG    PA   +++                S   S   +T+
Sbjct: 137 NGPLDNSCIQRFYDGIMFHDGTICKPAKLSILE---------------SSPSFSKATVTI 181

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
            EG+  Q+++M   VG     L R   G++ LD  L+ GE+R + 
Sbjct: 182 SEGKFHQIKKMFLCVGVKVTFLKRIRFGEFLLDESLSPGEYRPLN 226


>UniRef50_A8S8D3 Pseudouridine synthase n=1 Tax=Faecalibacterium prausnitzii M21/2
           RepID=A8S8D3_9FIRM
          Length = 233

 Score =  188 bits (477), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 55/204 (26%), Positives = 88/204 (43%), Gaps = 24/204 (11%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI----PVQGVYAA 75
           Q+K   +          Q    ++ NKP  V+   TD+    T+ + +    P + ++ A
Sbjct: 40  QLKDTDTVAVDGALLTYQKFVYLMLNKPEGVVSASTDKRD-TTVVDLVGDAYPRRELFPA 98

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP 135
           GRLD+ S G ++LT++G     +  P     K Y V ++   TQ+       GVTL DG 
Sbjct: 99  GRLDKTSTGFVLLTDDGGFAHDILSPRHHVSKTYTVTIDTPLTQEMCTGFAAGVTLADGT 158

Query: 136 TL-PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
            L PA    +                       +++ L +G   Q++RM    G     L
Sbjct: 159 ALSPAEVTALSPDGL-----------------TVRVVLRQGVYHQIKRMFGVYGAGVNAL 201

Query: 195 IRYAMGDYSLDN-LANGEWREVTD 217
            R A+G  +LD  LA G+WRE++D
Sbjct: 202 HREAIGGLALDAQLAPGQWRELSD 225


>UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indica subsp. indica
           ATCC 9039 RepID=B2IHU4_BEII9
          Length = 528

 Score =  188 bits (477), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 57/193 (29%), Positives = 92/193 (47%), Gaps = 20/193 (10%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI-----PVQGVYAAGRLDRDS 82
               +      TR+ LF+KP  ++    D  GR T+ +++      +  V + GRLD ++
Sbjct: 138 VDGEKLAARGHTRLFLFHKPRGLVTTNHDPEGRPTVFDYLHERHPDMPRVLSIGRLDINT 197

Query: 83  EGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAE 142
           EGLL+LTN+G L   L  P     + Y V+ +G   Q  L+ LR G+T++          
Sbjct: 198 EGLLLLTNDGGLSRLLELPTTGWVRRYRVRAKGTTDQAVLDQLRQGITIDGIHYAGMEVT 257

Query: 143 LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
                           +R+    SWL ++L EG+NR+V+R+   +G    RLIR + G +
Sbjct: 258 F---------------DREQGANSWLTLSLREGKNREVKRVLEQIGLEVNRLIRLSFGPF 302

Query: 203 SLDNLANGEWREV 215
            L +L  G+  EV
Sbjct: 303 QLGDLPEGDVTEV 315


>UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organisms
           RepID=A0NV51_9RHOB
          Length = 520

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 57/191 (29%), Positives = 94/191 (49%), Gaps = 17/191 (8%)

Query: 27  QRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEG 84
               +  P  + TR+ L++KP  ++    D  GR T+ E +P  +  V   GRLD ++EG
Sbjct: 150 VVDGQPLPMRERTRLWLYHKPRGLVTTNKDPEGRPTVFERLPDDLPRVLTVGRLDINTEG 209

Query: 85  LLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV 144
           LL+LTN+G L   L  P     + Y V+  G  TQ  L+ L++G+ +             
Sbjct: 210 LLLLTNDGGLARVLELPATGWLRRYRVRAFGKVTQPDLDTLKDGIAIEG----------- 258

Query: 145 DEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL 204
                L+       +++     W+ + L EG+NR+V+R+  H+G    RLIR + G + L
Sbjct: 259 ----VLYGAIEATLDKEQGNNVWMTVGLREGKNREVKRVLEHLGLAVNRLIRLSYGPFQL 314

Query: 205 DNLANGEWREV 215
            +L  G+ RE+
Sbjct: 315 MDLPEGDVREI 325


>UniRef50_C0W3E8 Pseudouridine synthase n=1 Tax=Actinomyces urogenitalis DSM 15434
           RepID=C0W3E8_9ACTO
          Length = 325

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 62/218 (28%), Positives = 86/218 (39%), Gaps = 42/218 (19%)

Query: 26  SQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFIP---- 68
           ++   R  P  Q  RV             +L +KP  V+    D  GR T+ +       
Sbjct: 110 TEPGVRVDPSRQEIRVDGSRVLTDPDVITVLLHKPAGVVTTMEDPQGRPTVADLAEQFIS 169

Query: 69  ----------VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
                        +   GRLD ++EGLL+L+N+G L  RL  P     K Y   VEG   
Sbjct: 170 EHRTELEHPESVRLVHVGRLDTETEGLLLLSNDGDLAHRLMHPSFEISKTYVAIVEGQVE 229

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
                 LR G+ L+DG        + D                    S ++ITL+ G+NR
Sbjct: 230 GWVPRKLRRGIELDDGLAQADRVVVKD---------------AGPSGSIVEITLHSGKNR 274

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            VRRM   VG P  RL R  +G   +  L  G+ R +T
Sbjct: 275 IVRRMLDAVGHPVTRLARTKLGPLGIGGLRPGQMRRLT 312


>UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis RepID=C8WBY9_ZYMMN
          Length = 509

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 66/217 (30%), Positives = 102/217 (47%), Gaps = 23/217 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT--RVILFNKPYDVLPQFTDEAGR 60
           +  I   T++K +     +           KP N PT  R+ L++K   +L    D  GR
Sbjct: 296 RIAIDGVTVEKPATL---LTSLDGVTVD-GKPVNAPTETRLFLYHKATGLLTTERDPEGR 351

Query: 61  KTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           KT+ + +P     V   GRLD ++EGLL+LT +G  +  L  P     + Y  +V G  +
Sbjct: 352 KTIYDRLPADLPRVMPVGRLDMNTEGLLLLTTDGGFKRMLELPATHIERCYRARVFGDVS 411

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           QD LE L  GVT++                  +       ER++    W+++ L+EGRNR
Sbjct: 412 QDQLEELIEGVTIDGIH---------------YGSIDANLERRTGRNGWVEMKLHEGRNR 456

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +VRR+  ++G    RLIR + G + L +L  G   EV
Sbjct: 457 EVRRVLGYLGLQVSRLIRISYGPFLLGDLPVGAVEEV 493


>UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LMR9_9FIRM
          Length = 239

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 56/184 (30%), Positives = 93/184 (50%), Gaps = 16/184 (8%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNG 92
           + +P R  LF+KP  V+   +D AGR+T+ ++     + V+  GRLD  SEGLL++TN+G
Sbjct: 58  KPEPLRYYLFHKPDCVITSVSDPAGRRTVMDYFRRVRERVFPVGRLDYHSEGLLLVTNDG 117

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L   LT P     K Y V V G  ++   + +  GV ++ G T P   E++   A    
Sbjct: 118 QLDFILTHPCHEVQKEYEVVVRGKFSEKLAKKMEKGVKIDSGVTAPCEIEVLGYDA---- 173

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
                        + L++ L+EG+NR++R+M     +P   L R      +L ++  G++
Sbjct: 174 ---------EKNKTRLRMVLHEGKNREIRKMMEIFHYPVFELKRIRYSFLTL-DVNRGQY 223

Query: 213 REVT 216
           R +T
Sbjct: 224 RRLT 227


>UniRef50_C6W5I1 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W5I1_DYAFD
          Length = 201

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 90/188 (47%), Positives = 118/188 (62%), Gaps = 12/188 (6%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKE--FIPVQGVYAAGRLDRDSEGLLVLTNNGALQAR 97
           +  L  KP+++L QF+ E   +TL +  F   + +Y  GRLD DSEGLL+LTN+  L+ +
Sbjct: 3   QYFLIYKPFNMLSQFSREGDHQTLADLGFTFAKDIYPVGRLDADSEGLLLLTNDNFLKTK 62

Query: 98  LTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL----NDGPTLPAGAELVDEPAWLWPR 153
           L +P  R  + YYVQVEG  T +A   L  GV++        TLPA    + EP  L  R
Sbjct: 63  LLEPRNRHTRTYYVQVEGEVTDEACRQLSAGVSISINGKQYKTLPAEIAKIAEPE-LPER 121

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA----- 208
           NPPIR RK+IPTSWL +TL EG+NRQVRRMTA VGFPTLRL+R+++G  SL +       
Sbjct: 122 NPPIRFRKNIPTSWLSVTLREGKNRQVRRMTAAVGFPTLRLVRWSIGKISLADKKINFPN 181

Query: 209 NGEWREVT 216
            G+  EVT
Sbjct: 182 PGDVWEVT 189


>UniRef50_A9KNY1 Pseudouridine synthase n=3 Tax=Firmicutes RepID=A9KNY1_CLOPH
          Length = 240

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 31/222 (13%)

Query: 3   QFIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           + +++ NT    +T   ++  K F       R+         + NKP  V+    D+  +
Sbjct: 33  RVMVNGNTETSPETKVDSNHDKIF----VDSRELSYVTLEYFMLNKPAGVVSASNDKK-Q 87

Query: 61  KTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            T+ + I     + ++  GRLD+D+EGLL++TN+G L  +L  P K   K+Y+ ++    
Sbjct: 88  TTVVDLIDEAKRKDLFPVGRLDKDTEGLLIITNDGDLAHQLLSPKKHVDKVYFAKLRDPL 147

Query: 118 TQDALEALRNGVTLNDGPT-LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            ++  EA   G+ +++  T LPA  E + E                       +T+ EG+
Sbjct: 148 KKEDEEAFAAGLKIDEEFTALPAKLERISEQEAY-------------------VTIREGK 188

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVTD 217
             Q++RM        + L R +MG   LD  L+ GE+RE+T+
Sbjct: 189 FHQIKRMFEATRNEVIYLKRISMGSLVLDESLSLGEYRELTE 230


>UniRef50_A5Z4I7 Pseudouridine synthase n=1 Tax=Eubacterium ventriosum ATCC 27560
           RepID=A5Z4I7_9FIRM
          Length = 175

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 58/179 (32%), Positives = 89/179 (49%), Gaps = 24/179 (13%)

Query: 43  LFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           + NKP  VL   +D    KT+ + +   P +G++  GRLD+D+EGLL++TN+G L   L 
Sbjct: 1   MLNKPAGVLSAVSDNNC-KTVIDLLDVTPKKGLFPVGRLDKDTEGLLLITNDGELSHNLL 59

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIR 158
            P K   K YYV++ G      +E    G+ + +   T PA  +++++            
Sbjct: 60  SPAKHVDKTYYVELNGDLIDSDIELFEKGLDIGEKNLTKPAILKILEK------------ 107

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
                  S   IT+ EG+  QV+RM   +G     L R  MG   LD NL  GE+R++T
Sbjct: 108 ------RSTALITITEGKYHQVKRMFQAIGLTVTFLKRLTMGPLKLDENLKPGEYRKLT 160


>UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium RepID=C8NNL7_COREF
          Length = 329

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 25/213 (11%)

Query: 10  TMQKTSFR-NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP 68
           T Q T    N  V R    R       N+     + NKP  +    +D+ GR  + + + 
Sbjct: 123 TTQGTRVNPNSDVIRVDGVRIN----INEDLEYFVLNKPRGMHSTMSDDLGRPCVGDLVS 178

Query: 69  V-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
                 Q ++  GRLD D+EGLL+LTN+G L  RL  P     K Y   V G    + + 
Sbjct: 179 EKTASGQRLFHVGRLDADTEGLLLLTNDGELANRLMHPKYEVRKTYLATVRGEAGPNLVT 238

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            LR G+ L DGP      +++D                    S +++ ++EGR   VRRM
Sbjct: 239 TLRKGIELEDGPAKADYVQIID---------------TFQGKSLIRLEIHEGRKHIVRRM 283

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
               GFP  RL+R  +    L     G  R + 
Sbjct: 284 LDEAGFPVERLVRTKLHTVQLGEQKPGSLRALN 316


>UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepID=A9MDW0_BRUC2
          Length = 611

 Score =  187 bits (475), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 102/216 (47%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRR-KPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   ++  +     VKR        +   + + TR+ L++KP  ++    D  GR 
Sbjct: 129 RIAVNGKVLESPAVN---VKRTDIITVDGKPLRQTERTRLWLYHKPAGLVTTNRDPEGRP 185

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ E +P +   V + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G  TQ
Sbjct: 186 TVFEALPPEMPRVLSVGRLDINTEGLLLLTNDGGLSRVLELPSTGWLRRYRVRAHGKVTQ 245

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L+NG+ ++        AEL               ER      W+ I L EG+NR+
Sbjct: 246 QQLDELKNGIAVDGVFYGSVEAEL---------------ERVQGANVWISIGLREGKNRE 290

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+ +   +G    RLIR + G + L +L  G  RE+
Sbjct: 291 VKNILGALGLTVGRLIRVSFGPFQLGDLEEGAVREI 326


>UniRef50_Q14P18 Pseudouridine synthase n=2 Tax=Mollicutes RepID=Q14P18_SPICI
          Length = 267

 Score =  187 bits (475), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 50/184 (27%), Positives = 84/184 (45%), Gaps = 15/184 (8%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           EN     ++ NK  + +    D   RKT+  ++    + +Y  GRLD D+ GLL+LTN+G
Sbjct: 56  ENSNKIYLMLNKRRNCVSTMYDPQHRKTVLTYVKGISERIYPVGRLDYDTSGLLLLTNDG 115

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
                +T P     K Y+V + G  ++  L+ L  G+ +  G                  
Sbjct: 116 EFTNIITHPSHIINKTYHVLLSGYLSKQQLQQLATGIEIEPGIIR------------SQA 163

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGE 211
           +   ++  +    S L +T++E    QV++M   +G   ++L R A+G   LD  L  GE
Sbjct: 164 QAKLVKYEEVKNVSILLLTIHEVTKHQVKKMIQSLGHEVIKLKRIAIGFLQLDETLKPGE 223

Query: 212 WREV 215
           WR +
Sbjct: 224 WRYL 227


>UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales RepID=C6J9Y4_9FIRM
          Length = 323

 Score =  187 bits (475), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 52/183 (28%), Positives = 90/183 (49%), Gaps = 20/183 (10%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGA 93
           +N+   ++LFNKP  ++     +    T+ +++     VY  GRLD++S+GLL+LTN G 
Sbjct: 68  KNEKKVLLLFNKPRGIVCSTKQQFDETTVTDYLDYPLRVYPVGRLDKESQGLLLLTNEGD 127

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  ++ + G    K Y+V V     ++ +  +  GV + D  T P       E +     
Sbjct: 128 LVNKIMRAGNYHEKEYFVTVNKPVDREFVRRMSKGVPVLDTVTRPCRVVQTGECS----- 182

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                          +I L +G NRQ+RRM  ++G+   +L R  + + +LD +  GE+R
Sbjct: 183 --------------FRIILTQGLNRQIRRMCRYLGYEVQKLKRIRIMNLTLDGIREGEYR 228

Query: 214 EVT 216
           E+T
Sbjct: 229 EIT 231


>UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silvestris BL2
           RepID=B8ETE9_METSB
          Length = 676

 Score =  186 bits (473), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 57/187 (30%), Positives = 91/187 (48%), Gaps = 20/187 (10%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP-----VQGVYAAGRLDRDSEGLLVL 88
            E   TR+ LF+KP  ++    D  GR T+ +++         + + GRLD ++EGLL+L
Sbjct: 79  AERARTRLFLFHKPRGLVTTEHDPEGRPTVFDYVREHSPEAPRLVSIGRLDINTEGLLLL 138

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           TN+G L   L  P     + Y V+ +G   Q  L+ LR GVT+                 
Sbjct: 139 TNDGGLARVLELPATGWARRYRVRAKGSIDQPTLDRLRQGVTVEG--------------- 183

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLA 208
             + +     +R      WL ++L EG+NR+++R+  H+G    RLIR + G + L +L 
Sbjct: 184 VDYAQIEATLDRIQGANCWLTMSLREGKNREIKRVLEHLGLEVNRLIRLSYGPFQLADLE 243

Query: 209 NGEWREV 215
            G+  EV
Sbjct: 244 EGKVEEV 250


>UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis excentricus CB 48
           RepID=C5SKU3_9CAUL
          Length = 489

 Score =  186 bits (473), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 61/183 (33%), Positives = 96/183 (52%), Gaps = 12/183 (6%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNG 92
           + +PTRV  ++KP  ++    D  GR T+   +P +   V + GRLD +SEGLL+LTN+G
Sbjct: 101 KAEPTRVWRYHKPVGLMTTHQDPQGRPTVFNSLPQELPRVISVGRLDINSEGLLLLTNDG 160

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            L   L  P     ++Y V+  G  TQ+AL+ L+ GVT+      P  A+L         
Sbjct: 161 ELARALELPTTGWTRVYRVRALGRTTQEALDTLKTGVTVEGVQYGPIEAKL--------- 211

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
            +    +       W+ ++L EG+NR+VR++   +G    RLIR A G + L ++  GE 
Sbjct: 212 -DKAQEKADGRANLWITVSLNEGKNREVRKVLDSLGLKVNRLIRLAYGPFQLGDIEPGEV 270

Query: 213 REV 215
            E+
Sbjct: 271 EEI 273


>UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae RepID=Q7MMX9_VIBVY
          Length = 347

 Score =  186 bits (472), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 49/184 (26%), Positives = 84/184 (45%), Gaps = 19/184 (10%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
              +    I  NKP  +            +      + ++  GRLD+ S+GL+ LTN+G 
Sbjct: 60  AAKEKPVYIALNKPTGITCTTERNIPGNIVDFIGHKKRIFPIGRLDKPSDGLIFLTNDGD 119

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           +  ++ + G    K Y V+V+   T + ++A+ +GV + D  TLP       + +     
Sbjct: 120 IVNKILRAGNHHEKEYVVRVDKPITPEFIKAMSSGVNILDTVTLPCKVTQETKFS----- 174

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                          +I L +G NRQ+RRM   +G+   +L R  + + SLD + NG+WR
Sbjct: 175 --------------FRIVLTQGLNRQIRRMCEALGYEVFKLRRVRIMNISLDGIPNGKWR 220

Query: 214 EVTD 217
            +TD
Sbjct: 221 YLTD 224


>UniRef50_UPI0001C337CA ribosomal large subunit pseudouridine synthase B n=1
           Tax=cyanobacterium UCYN-A RepID=UPI0001C337CA
          Length = 254

 Score =  186 bits (472), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 66/209 (31%), Positives = 95/209 (45%), Gaps = 27/209 (12%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-----GV 72
           NH +     +     K        IL NKP  ++    D   R  + + +P       G+
Sbjct: 45  NHDLLELDGKIIKSHK--KTQLFYILVNKPVGIICSCKDSQNRSIVMDLLPSNLRKGMGI 102

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
           +  GRLD +S G L+LTN+G L  RLT P     KIY V V G  TQ  L+  R GV L+
Sbjct: 103 HPVGRLDMNSSGALLLTNDGNLTLRLTHPRYHLPKIYEVLVRGNFTQAILKDWRQGVVLD 162

Query: 133 DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTL 192
              TLPA  E+++                +   + LKI L EG+NR +RR+        +
Sbjct: 163 GKKTLPAYLEVINN---------------NRQYTNLKIILTEGKNRHIRRIAQKFELDVI 207

Query: 193 RLIRYAMGDYSL-----DNLANGEWREVT 216
           +L R A+G  SL     DN+  G +R ++
Sbjct: 208 KLHRTAIGPISLSTSKVDNVKLGHYRLLS 236


>UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gasseri
           RepID=Q042N1_LACGA
          Length = 245

 Score =  186 bits (472), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 60/202 (29%), Positives = 94/202 (46%), Gaps = 20/202 (9%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP----VQGVYAA 75
           QVK          K   Q     L NKP  V+    D   ++T+   +      QG+   
Sbjct: 52  QVKETDLVAVDGNKIAYQQYHYFLLNKPKGVISATED-RSQQTVISLLKTKDRYQGIAPV 110

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG- 134
           GRLD+D+ GLL+LTN+GAL   L  P K   K+Y  ++ G+P  +  +    G+ L DG 
Sbjct: 111 GRLDKDTTGLLLLTNDGALAHELLAPNKHVAKVYRAKIAGVPDPETAKKFAQGLILGDGT 170

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
              PA  +++             ++ +    S ++I + EG+  Q++RM   VG   L L
Sbjct: 171 KLKPAKLKIL-------------KQDQDNNLSQIEIQIQEGKYHQIKRMFGAVGMKVLEL 217

Query: 195 IRYAMGDYSLD-NLANGEWREV 215
            R +MG   L  +L  GE++E+
Sbjct: 218 DRVSMGKLHLPADLKRGEYKEI 239


>UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacteria
           RepID=Q13BM8_RHOPS
          Length = 795

 Score =  186 bits (472), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 61/184 (33%), Positives = 93/184 (50%), Gaps = 17/184 (9%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNN 91
           PE + TR+ L++KP  ++    D  GR T+ + +P  +  + + GRLD ++EGLL+LTN+
Sbjct: 530 PERERTRLFLYHKPRGLMTTHADPEGRPTVFDNLPEDLPRLISIGRLDFNTEGLLLLTND 589

Query: 92  GALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLW 151
           G L   L  P     + Y V+  G  TQ  L+ L +GV ++     P  A+L        
Sbjct: 590 GGLARALELPETGWLRRYRVRAHGEVTQAQLDQLASGVEVDGVKYGPIEAKL-------- 641

Query: 152 PRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
                  ER      WL   + EG+NR+VR + AH+G    RLIR + G + L  +  G+
Sbjct: 642 -------ERDQGANVWLVFAIREGKNREVRNVLAHLGLEVNRLIRVSYGPFQLLEIEEGQ 694

Query: 212 WREV 215
             EV
Sbjct: 695 VEEV 698


>UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SBU8_LEPBA
          Length = 243

 Score =  186 bits (472), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 56/218 (25%), Positives = 94/218 (43%), Gaps = 26/218 (11%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   ++      +++               +     + NK  D +    D    KT+ +
Sbjct: 32  VNGLVVKDP---GYKITLTDIVVYYDETLNRKEFYYFMMNKAPDCITATEDPRE-KTVMD 87

Query: 66  FIPVQG----VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           ++  +     ++  GRLD+++EGLL+ T +G L    T P     K YY ++    T   
Sbjct: 88  YLSERHRNMNLFPIGRLDKETEGLLLFTTDGTLAHYYTSPKHFVEKEYYAEISAPVTAFD 147

Query: 122 LEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           +    +G+TL+DG  TLPA   +            P      I T WL+    EG+ RQ+
Sbjct: 148 ISQFESGITLDDGYKTLPARLAI------------PDPSNPHIATVWLR----EGKYRQI 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           RRM   +G     L R  MG+  LD +L  G +RE+T+
Sbjct: 192 RRMFQSLGKEVQYLKRVKMGNLELDRDLEVGSYRELTE 229


>UniRef50_O32068 Uncharacterized RNA pseudouridine synthase ytzG n=68 Tax=Bacteria
           RepID=YTZG_BACSU
          Length = 239

 Score =  185 bits (471), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 59/200 (29%), Positives = 94/200 (47%), Gaps = 21/200 (10%)

Query: 20  QVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ---GVYAA 75
            V   + + +   +P + +    ++ NKP  VL    D   +  +    P +     + A
Sbjct: 40  HVDPDTQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPA 99

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG- 134
           GRLD+D+EG L+LTN+G L  RL  P K   K Y V ++   +++ +  L  GV +  G 
Sbjct: 100 GRLDKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGY 159

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
            T PA AE+    +                 + + +T+ EG+  QV++M   VG   + L
Sbjct: 160 KTKPAKAEIKTNDS---------------GNTVIYLTITEGKYHQVKQMAKAVGNEVVYL 204

Query: 195 IRYAMGDYSLD-NLANGEWR 213
            R +MG  SLD  LA GE+R
Sbjct: 205 KRLSMGRVSLDPALAPGEYR 224


>UniRef50_C2KV26 Pseudouridylate synthase n=1 Tax=Oribacterium sinus F0268
           RepID=C2KV26_9FIRM
          Length = 239

 Score =  185 bits (471), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 57/220 (25%), Positives = 107/220 (48%), Gaps = 27/220 (12%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRKTLK 64
           I+   ++  S    +V+  +S+   + +P   +     + NKP  VL    D   +KT+ 
Sbjct: 29  INGEIVKDPS---MEVQPGNSEIVYKDEPIHYEEFSYYMMNKPVGVLSSTED-RKQKTVL 84

Query: 65  EFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           +    +    ++  GRLD+DSEGLL++ N+GAL  +L  P     K Y V++ G  +++ 
Sbjct: 85  DLFSDKHRKDLFPVGRLDKDSEGLLLIMNDGALAHKLLSPKMHIEKKYLVEIPGKISEEE 144

Query: 122 LEALRNGVTLN-DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           L+ LR G+  + D   +PA A  +                 +   S +++ + EG+  Q+
Sbjct: 145 LDRLRQGIQYDTDLIAMPAKARCLS---------------STEEGSRVEVIIMEGKFHQI 189

Query: 181 RRMTAHV--GFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           ++M   +   +   +L R +MG   LD  LA GE+R++++
Sbjct: 190 KKMFLALSTDYVVTKLQRLSMGPLHLDPALAPGEYRKLSE 229


>UniRef50_B9JSE7 Ribosomal large subunit pseudouridine synthase B n=4
           Tax=Alphaproteobacteria RepID=B9JSE7_AGRVS
          Length = 704

 Score =  185 bits (471), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 51/181 (28%), Positives = 91/181 (50%), Gaps = 17/181 (9%)

Query: 37  QPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGAL 94
           + TR+ L++KP  ++   +D  GR T+ + +P +   V + GRLD ++EGLL+LTN+G L
Sbjct: 140 ERTRLWLYHKPSGLVTTNSDPEGRPTVFDNLPEELPRVMSIGRLDINTEGLLLLTNDGGL 199

Query: 95  QARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRN 154
              L  P     + Y V+  G   Q  L+ L++G+ ++                 L+   
Sbjct: 200 ARVLELPTTGWLRRYRVRAYGEIDQAKLDTLKDGIAVDG---------------VLYGAI 244

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
             + +R      W+ + L EG+NR+++ +   +G    RLIR + G + L +L   + +E
Sbjct: 245 DAVLDRSQGHNVWITMGLREGKNREIKNVLGALGLEVNRLIRISYGPFQLGDLPESQVQE 304

Query: 215 V 215
           V
Sbjct: 305 V 305


>UniRef50_B6BUN1 Pseudouridine synthase n=1 Tax=beta proteobacterium KB13
           RepID=B6BUN1_9PROT
          Length = 257

 Score =  185 bits (471), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 52/202 (25%), Positives = 96/202 (47%), Gaps = 19/202 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYA 74
            +++   + +R   +  E + +R+I+++KP   +   +D   +KT+ + +P        +
Sbjct: 56  GNEIIHINGRRIYFKNAEKRESRLIIYHKPEGEIVSHSDPKHQKTVFQKLPKVKNGKWIS 115

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
            GRLD ++ GLL++TN+G L   +  P ++  + Y V++ G  T++ +  +R GV L+DG
Sbjct: 116 IGRLDINTSGLLLITNDGKLANHMMHPSQQIDREYSVRILGEVTEEIINNIRKGVKLDDG 175

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
                  E                        W +I L EGRNR++RR+         RL
Sbjct: 176 VAHVDTFE---------------HTGGEGANQWFRIILKEGRNREIRRLVESQNLKVSRL 220

Query: 195 IRYAMGDYSLDN-LANGEWREV 215
           IR   G  +L + L  G++ E+
Sbjct: 221 IRTRYGPLNLPSHLKRGQFMEL 242


>UniRef50_D0SB72 Pseudouridine synthase n=5 Tax=Acinetobacter RepID=D0SB72_ACIJO
          Length = 368

 Score =  185 bits (471), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 86/215 (40%), Gaps = 20/215 (9%)

Query: 6   ISENTMQ-KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLK 64
           ++    Q           R   ++ + +  +    RV+++ KP   +    D   R T+ 
Sbjct: 31  VNGQVAQVGERIEPGDELRIDGRKVSFQIEDEIRRRVLIYYKPEGEICSRNDPESRPTVF 90

Query: 65  EFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + +P          GRLD +S GLL+ TN+G L  RL  P     + Y V+V G  T   
Sbjct: 91  DQLPAIANDRWVMVGRLDINSTGLLLFTNDGELANRLMHPSNEVEREYAVRVMGEVTPQI 150

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
              +  GV L+DG   PA  E   E                    W ++ + EGRNR+VR
Sbjct: 151 KNNMLKGVVLDDG---PAKFESFSEIGG------------EGINRWYQVVVKEGRNREVR 195

Query: 182 RMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           R+    G    RL+R   G   L   L  G W E+
Sbjct: 196 RIFESQGLKVSRLLRTRYGTVILPRELRTGRWMEL 230


>UniRef50_Q2NZN4 Pseudouridine synthase n=13 Tax=Xanthomonadaceae RepID=Q2NZN4_XANOM
          Length = 286

 Score =  185 bits (471), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 16/215 (7%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRKTLK 64
           +S   ++   F     ++FS     +  P   P R  ++ NKP  V+    DE GR T+ 
Sbjct: 65  VSARVVRDPEFPIRADQQFSITVDGQ--PLTGPARCYLMLNKPRGVVTTVRDEQGRDTVY 122

Query: 65  EFIPVQGV---YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
                 G+      GRLD+ SEGLL+ +N+    A +T P     K Y+VQ++ +P    
Sbjct: 123 RCFDGAGLPWIAPVGRLDKASEGLLLFSNDPQWAATVTDPATGPDKTYHVQIDCLPNVAQ 182

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L  L+ GV   D           +    L         R+    +WL+I L EGRNRQ+R
Sbjct: 183 LAQLQAGVVDPD----------PEGEGMLLRAKQVSVLREGERNAWLEIVLDEGRNRQIR 232

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R+ A V    LRL+R A+G  ++  L  G WR ++
Sbjct: 233 RLLAAVDIGVLRLMRVAIGPLAMGELGKGAWRMLS 267


>UniRef50_B3DRY9 Pseudouridine synthase n=7 Tax=Bifidobacterium RepID=B3DRY9_BIFLD
          Length = 256

 Score =  185 bits (470), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 61/210 (29%), Positives = 93/210 (44%), Gaps = 31/210 (14%)

Query: 23  RFSSQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI-- 67
              ++  TR  P  Q  RV             +  NKP  VL    D  GR TL++ +  
Sbjct: 49  ELVTELGTRVDPHKQQVRVDGSRVRVNPNHVTLALNKPRKVLSAMDDPKGRYTLRDIVGD 108

Query: 68  PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL-R 126
             + ++  GRLD DSEGL+++TN+G L   +  P     K Y   +EG  +      L  
Sbjct: 109 KYERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYVATLEGKISGTVCRRLVT 168

Query: 127 NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
            GV L+DG        ++D                S   + +K+ L+ G+NR VRR+   
Sbjct: 169 TGVQLDDGWIKLDHCAIID---------------SSRDHTMVKVVLHSGKNRIVRRIFGS 213

Query: 187 VGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +GFP  RL+R  +G   L +L  G +R ++
Sbjct: 214 IGFPVKRLVRTQIGPIKLGDLKPGSYRVLS 243


>UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q15Q67_PSEA6
          Length = 241

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 56/212 (26%), Positives = 95/212 (44%), Gaps = 29/212 (13%)

Query: 10  TMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVI-LFNKPYDVLPQFTDEAGRKTLKEFIP 68
           T++    ++  +K   +      +  + P  ++ + NKP   +    +  G + + + +P
Sbjct: 41  TVKGEFAKSPALKVDPATVRVDGEALDAPDGILVMLNKPLGYVCSHDNNEGMR-IYDLLP 99

Query: 69  VQ------GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
            +       + + GRLD+D+ GL+++T++  L  +LT P     K+Y V V+     D +
Sbjct: 100 ERWEFRNPKIVSVGRLDKDTSGLILVTDDTKLVHQLTSPKHHVDKVYQVSVDCPLQSDII 159

Query: 123 EALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           ++   GV L +G    LPA  E+V E                       +TL EG+  QV
Sbjct: 160 DSFAKGVVLGEGAEQCLPAKIEIVSENVA-------------------NVTLNEGKYHQV 200

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           RRM A  G+    L R   G Y L +LA GEW
Sbjct: 201 RRMFAACGYHVEALHRSQFGQYRLQDLAQGEW 232


>UniRef50_Q1YVK2 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q1YVK2_9GAMM
          Length = 235

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 60/184 (32%), Positives = 82/184 (44%), Gaps = 26/184 (14%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQA 96
           R  + NKP  V+    D     T  + I       +  AGRLD D+ GLL++T++G    
Sbjct: 61  RYFMLNKPAGVVSATKDSNN-STALDLIFEHRSDELQIAGRLDIDTTGLLLITDDGQWNH 119

Query: 97  RLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRN 154
           RLT P     KIY V +    T D  E L NGV L     P LPA  E +D+   L    
Sbjct: 120 RLTSPRSDCQKIYRVTLGIPITPDYAEKLANGVWLKGEKHPCLPATMEQIDDETVL---- 175

Query: 155 PPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWR 213
                          +++ EG+  QV+RM A +G     L R  +G   LD  L  G++R
Sbjct: 176 ---------------LSIAEGKYHQVKRMFAALGNHVEALHRTQVGGIILDESLEPGDYR 220

Query: 214 EVTD 217
            +TD
Sbjct: 221 ALTD 224


>UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alexandrii HTCC2633
           RepID=A3UFV9_9RHOB
          Length = 354

 Score =  184 bits (469), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 19/208 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   ++  +F+         +       +  PTRV  ++KP  +L   +D  GR T+ +
Sbjct: 45  VNGEILRTPAFKVMAGD--DVRVDGESIGQRPPTRVWRYHKPVGLLTTHSDPQGRDTVFQ 102

Query: 66  FIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P     V + GRLD +SEGLL+LTN+G L   L  P     + Y V+  G  +  AL 
Sbjct: 103 TLPQDMGRVISVGRLDLNSEGLLLLTNDGELARVLELPSTGWTRRYRVRAYGNASDKALA 162

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
            L NG  ++     P    +               +R++    WL + + EG+NR+VR++
Sbjct: 163 ELENGTVVDGVVYGPVEVTV---------------DRRTGANVWLTVGIKEGKNREVRKV 207

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGE 211
              VG    RL+R A G + L +L  GE
Sbjct: 208 LQSVGLTVNRLMRVAYGPFQLGSLKRGE 235


>UniRef50_C7NBL1 Pseudouridine synthase n=3 Tax=Leptotrichia RepID=C7NBL1_LEPBD
          Length = 252

 Score =  184 bits (469), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 60/207 (28%), Positives = 99/207 (47%), Gaps = 8/207 (3%)

Query: 17  RNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ----GV 72
           + H  +     +   +    +P   I+ NKP  V+    D +  KT+ + +  +     +
Sbjct: 38  KIHVDEEKDIVKYENKIINYKPFVYIMMNKPAGVISATED-SHHKTVIDLLNDEYRTYDI 96

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
           +  GRLD D+EGL++LTN+G L   L  P K   K YYV++    ++D ++ L NG+ L 
Sbjct: 97  FPVGRLDIDTEGLILLTNDGILSHNLLSPKKHVDKKYYVKITKSLSEDDIKTLENGIKLE 156

Query: 133 DG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSW-LKITLYEGRNRQVRRMTAHVGFP 190
           +   T  A  E++   +     +    E ++      + IT+ EG+  QV+RM   VG  
Sbjct: 157 ENFITKNAKVEIICNNSEKESEDFDFGENENNKNENSVYITISEGKFHQVKRMFKAVGNE 216

Query: 191 TLRLIRYAMG-DYSLDNLANGEWREVT 216
            L L R  MG     +NL  G +RE+T
Sbjct: 217 VLYLKRVKMGNLLLDENLELGGYRELT 243


>UniRef50_A1U6Q2 Pseudouridine synthase n=4 Tax=Gammaproteobacteria
           RepID=A1U6Q2_MARAV
          Length = 231

 Score =  184 bits (468), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 62/207 (29%), Positives = 92/207 (44%), Gaps = 27/207 (13%)

Query: 17  RNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGV 72
           + ++            KP N P    ++ +KP  VL   TD + + T  + +P      V
Sbjct: 36  QANRQVEAEQSVHLDGKPVNPPGDIYLMMHKPAGVLSATTD-SSQPTALDLLPRGLASRV 94

Query: 73  YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLN 132
           + AGRLD+D+ GLL+LT++G     +T P +   K Y V +     + A  AL  GV LN
Sbjct: 95  HIAGRLDKDTTGLLLLTSDGQWSHAVTSPRRECRKSYRVWLAEAIPEQACRALEKGVMLN 154

Query: 133 DG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFP 190
                T PA   +                        + +T+ EGR  QV+RM A VG  
Sbjct: 155 GETTETRPAEVRV-------------------HNNQLIDLTIGEGRYHQVKRMLAAVGNR 195

Query: 191 TLRLIRYAMGDYSLDN-LANGEWREVT 216
              L R+ +G   LD+ LA GE+R +T
Sbjct: 196 VEALHRFRIGSIELDDKLAPGEFRALT 222


>UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (class)
           RepID=B0RHF4_CLAMS
          Length = 291

 Score =  184 bits (468), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 89/216 (41%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK- 61
           +  ++  T+ +   R             +    +   R ++ NKP  +     DE GR  
Sbjct: 50  RVTVNGETVTEPGRRI-DPDVDEVAVDDQAVQLDTSKRYLMLNKPVGIYSSLRDERGRPD 108

Query: 62  -TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
                    + ++  GRLD ++ GLL+LTN+G L   L  P     K Y  +V G  T  
Sbjct: 109 LREFTEEFEERLFNVGRLDAETSGLLILTNDGDLAHVLAHPSFGVLKTYIAKVTGRVTPQ 168

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            ++ L  GV L DGP     A ++                     + ++ITL+ GRNR V
Sbjct: 169 TIQRLTQGVDLEDGPIQADRARILS---------------GGGDQTLVEITLHSGRNRIV 213

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   VG P   L+R   G   L +L  G  R++T
Sbjct: 214 RRMLDEVGHPVEELVRRQFGPLHLGSLGVGRVRDLT 249


>UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas RepID=B4W9R3_9CAUL
          Length = 519

 Score =  184 bits (468), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 62/195 (31%), Positives = 95/195 (48%), Gaps = 10/195 (5%)

Query: 25  SSQRSTRRKP--ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDR 80
               +   KP    Q TRV  ++KP  +L   +D  GR T+ + +P     V + GRLD 
Sbjct: 129 DDVITVDGKPIGSTQATRVWRYHKPAGLLTSHSDPTGRPTVFDALPAGLPRVISVGRLDL 188

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAG 140
            +EGLL+LTN+G L   L  P     + Y  +  G  TQ+ L+ L++GV ++     P  
Sbjct: 189 ATEGLLLLTNDGELSRALELPATSLVRQYRARARGKITQEQLDKLKDGVVVDGVSYGPIE 248

Query: 141 AELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG 200
           A L         +     + ++    W+ +++ EG+NR+VR++   VG    RLIR A G
Sbjct: 249 ATL------DKAKESKSEDGRAPANLWISVSITEGKNREVRKVLESVGLTVNRLIRLAYG 302

Query: 201 DYSLDNLANGEWREV 215
            + LD L  G   EV
Sbjct: 303 PFRLDVLPIGSVEEV 317


>UniRef50_A6DMJ6 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DMJ6_9BACT
          Length = 239

 Score =  184 bits (468), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 59/218 (27%), Positives = 93/218 (42%), Gaps = 32/218 (14%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           I +   + T    + V  F  +    R+     T   + NKP   +    DE   KT+ +
Sbjct: 39  IPQKVGKSTIDLANDVVTFDGEVLEYRE-----TIYFMLNKPKGYVCAAKDERL-KTVLD 92

Query: 66  FIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +P     +  ++ GRLD D+ GL++LT++G     +T P ++  K Y V      + + 
Sbjct: 93  LLPPALASREPFSCGRLDIDTTGLVILTDDGTWAHGITSPKRKCEKSYLVGSVSELSDED 152

Query: 122 LEALRNGVTL--NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +  L  GV L  +D  T PA  E +DE                      ++ + EGR  Q
Sbjct: 153 MRNLEQGVYLDGDDKITAPAKIEKIDEK-------------------TYRLKITEGRYHQ 193

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           V+RM   V      L R  +G  SL D+L  G WR++T
Sbjct: 194 VKRMFEAVDNMVKSLHREQIGGLSLDDDLDEGNWRDLT 231


>UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii DSM 20583
           RepID=C9L6I1_RUMHA
          Length = 271

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 60/205 (29%), Positives = 96/205 (46%), Gaps = 20/205 (9%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKPENQPTRVIL-FNKPYDVLPQFTDEAGRKTLKEFIPVQG 71
           K + +  QV+ F   +   +  + +  +V+L F+KP  +         +  +        
Sbjct: 32  KPAVQGMQVEDFQEIKVDGKAIKREEKKVLLVFHKPKGIECTANPNVKKNVISYINYPIR 91

Query: 72  VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL 131
           VY AGRLD+DSEGLL+LTN G L  ++ + G    K Y V V+   T++ L+++R GV +
Sbjct: 92  VYYAGRLDKDSEGLLLLTNQGELVNQIMKAGSYHEKEYLVTVDKPVTEEFLQSMREGVPV 151

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
               T     E   E                      +ITL +G NRQ+RRM  ++G+  
Sbjct: 152 LGTITRKCKVEKESEKV-------------------FRITLTQGLNRQIRRMCNYLGYEV 192

Query: 192 LRLIRYAMGDYSLDNLANGEWREVT 216
           ++L R  + +  L NL  G +RE T
Sbjct: 193 VKLKRIRIMNIELGNLPIGSYREAT 217


>UniRef50_A8ZRV1 Pseudouridine synthase n=3 Tax=Desulfobacteraceae
           RepID=A8ZRV1_DESOH
          Length = 241

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 59/209 (28%), Positives = 90/209 (43%), Gaps = 23/209 (11%)

Query: 12  QKTSFRNHQVKRFSSQR--STRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV 69
           Q  +    +V   S        R    +    I  NKP   +     +    T+ E + V
Sbjct: 41  QVVTELGTKVDPESDDVMFDGHRVTLAESHVYIALNKPPGYVTSCL-QKQETTVMELVAV 99

Query: 70  -QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNG 128
            Q V+  GRLD+ S GLL++T++G L  RL+ P     K Y V  +   +   L+A+R G
Sbjct: 100 DQRVFPVGRLDKPSCGLLLMTSDGGLHQRLSHPSFDHEKEYDVACDRPVSDADLDAMRRG 159

Query: 129 VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVG 188
           + +    T PA  + + +  +L                   I L EGRNRQ+RRM   +G
Sbjct: 160 MVITGRKTRPAKVKRLSDRRFL-------------------IILQEGRNRQIRRMAEMLG 200

Query: 189 FPTLRLIRYAMGDYSLDNLANGEWREVTD 217
              + L R  +    L +LA G WR +T+
Sbjct: 201 NRVVLLRRIRIAHIHLGDLAEGRWRYLTE 229


>UniRef50_A8I6C3 Pseudouridine synthase n=6 Tax=Alphaproteobacteria
           RepID=A8I6C3_AZOC5
          Length = 717

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 62/212 (29%), Positives = 96/212 (45%), Gaps = 19/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++   +   +F          +      PE + TR+ L++KP  V+    D  GR TL E
Sbjct: 58  VNGEVLASPAFTVTAEDEI--RVDGEPLPERERTRLFLYHKPIGVVTTNRDPEGRTTLFE 115

Query: 66  FIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALE 123
            +P  +  + + GRLD +SEGLL+LTN+G L   L  P     + Y V+ +G   Q  L+
Sbjct: 116 LLPGHLPRLVSVGRLDINSEGLLLLTNDGGLARVLELPETGWLRRYRVRAKGTVDQAQLD 175

Query: 124 ALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183
           AL  G+ +      P  A               + +R      W+ + L EG+NR+VR +
Sbjct: 176 ALIKGIVVEGVEYGPIEA---------------VLDRVQGANVWITVALREGKNREVRNV 220

Query: 184 TAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
              +G    RLIR + G + L  +A G   EV
Sbjct: 221 LGALGLQVNRLIRISYGPFQLGEIAEGGVEEV 252


>UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S1L0_FINM2
          Length = 242

 Score =  183 bits (466), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 57/215 (26%), Positives = 100/215 (46%), Gaps = 19/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +   S++ +       +   ++    +    I  NKP        D+   K 
Sbjct: 26  KVYVNGTILLDLSYQVNDTDIV--EVEGKKINLKEDKIYIAINKPIGYASTVKDKFADKK 83

Query: 63  LKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + I     VY  GRLD+DS GLL+LTN+G     LT P     KIY V V+G P +  
Sbjct: 84  VVDLIKSDTRVYPVGRLDKDSHGLLILTNDGEFTYELTHPKFEHKKIYEVLVKGKPNKTE 143

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           ++ L++G+ L+      +  E ++                    +  ++T++EGRNRQ+R
Sbjct: 144 IKQLKDGILLDGYKLKKSKIEFIENV---------------KNDTKYRVTIFEGRNRQIR 188

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREV 215
           RM   +  P L L R  +G+Y ++N L +GE++ +
Sbjct: 189 RMFDFINHPVLDLKRVQIGNYKMENSLKSGEYKLL 223


>UniRef50_B2HUK5 Pseudouridine synthase n=9 Tax=Gammaproteobacteria
           RepID=B2HUK5_ACIBC
          Length = 307

 Score =  183 bits (466), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 59/193 (30%), Positives = 84/193 (43%), Gaps = 20/193 (10%)

Query: 28  RSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVYAAGRLDRDSE 83
           R  + + E++   RV+++ KP   +    D   R T+ + +P          GRLD +S 
Sbjct: 53  RKVQFQIEDEIRRRVLIYYKPEGEICSRNDPEKRPTVFDHLPQIANDRWVMVGRLDINST 112

Query: 84  GLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAEL 143
           GLL+ TN+G L  RL  P     + Y V+V G  T    + + NGV L DG   PA  E 
Sbjct: 113 GLLLFTNDGELANRLMHPSNEIEREYAVRVMGEVTPQLRQNMVNGVELEDG---PAKFES 169

Query: 144 VDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYS 203
             E                    W ++ + EGRNR+VRR+    G    RL+R   G   
Sbjct: 170 FSEIGG------------EGINRWYQVVVKEGRNREVRRIFESQGLKVSRLLRTRYGTVI 217

Query: 204 L-DNLANGEWREV 215
           L   L  G W E+
Sbjct: 218 LPRELRTGRWMEL 230


>UniRef50_A5ZYR1 Pseudouridine synthase n=2 Tax=Clostridiales RepID=A5ZYR1_9FIRM
          Length = 315

 Score =  183 bits (466), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 57/194 (29%), Positives = 89/194 (45%), Gaps = 22/194 (11%)

Query: 25  SSQRSTRRKPENQPTR--VILFNKPYDVLPQFTDEAGRKTLKEFIPVQ-GVYAAGRLDRD 81
            ++     +P    TR  ++LF KP  ++     +    T+ EF+     VY  GRLD+D
Sbjct: 55  DAEVFLDGRPVKAETRQVLLLFYKPRGIVCSTKKQRQETTVTEFLDYPVRVYPVGRLDKD 114

Query: 82  SEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGA 141
           SEGLL+LTN G L  R+ + G    K Y V V+   T+  +  + +GV +    T P   
Sbjct: 115 SEGLLLLTNQGDLVNRIMRAGNYHEKEYEVTVDKKITETFIRKMSSGVPILGTVTRPCTV 174

Query: 142 ELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 201
               + +                     I L +G NRQ+RRM  ++G+    L R  + +
Sbjct: 175 YKTGDKS-------------------FSIILTQGLNRQIRRMCEYLGYHVCTLKRIRIMN 215

Query: 202 YSLDNLANGEWREV 215
            +LD L  GE+RE+
Sbjct: 216 LTLDGLKCGEYREI 229


>UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovibrio salexigens DSM
           2638 RepID=C6BUF1_DESAD
          Length = 251

 Score =  183 bits (466), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 58/186 (31%), Positives = 88/186 (47%), Gaps = 17/186 (9%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV----QGVYAAGRLDRDSEGLLVLTN 90
           E      IL +K  + +    D  GRKT+ + +P     + V+  GRLD  SEG+L+LT 
Sbjct: 65  EKSKDLYILLHKTIETVTTAKDPQGRKTVLDLLPPDVINRRVFPVGRLDFYSEGMLLLTT 124

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G L  R+T P     KIY+V + G  ++  L  ++NG+ L D   L A  ++       
Sbjct: 125 DGELCNRMTHPKWHLPKIYHVTIRGKLSEKELSVMQNGMYLEDKGELLAPVKI------- 177

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
                     +   T+  ++ L +G NRQ+RRM        LRL R   G   L  L  G
Sbjct: 178 ------KAISEVGETTKYEMELRQGINRQIRRMFGEFDKTILRLKRVRQGRIELGALKPG 231

Query: 211 EWREVT 216
           +WRE++
Sbjct: 232 KWRELS 237


>UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K31
           RepID=B0T1Z8_CAUSK
          Length = 501

 Score =  183 bits (465), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 59/183 (32%), Positives = 91/183 (49%), Gaps = 12/183 (6%)

Query: 35  ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNG 92
           E + TRV  ++KP  ++    D   R T+ + +P  +  + + GRLD +SEGLL+LTN+G
Sbjct: 79  EPEATRVFRYHKPSGLMTTHNDPKQRPTVFQALPRDLPRLISVGRLDLNSEGLLLLTNDG 138

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
           AL   L  P     + Y  +  G  TQ  L+ L++G T+      P  A L         
Sbjct: 139 ALSRALEMPQNAWVRRYRARAFGDTTQAKLDKLKDGCTVEGVRYGPIEARL--------- 189

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
            +    +       W+ +TL EG+NR+VRR+   +G    RLIR + G ++L  L  G+ 
Sbjct: 190 -DKAQEKAGGGKNIWITLTLSEGKNREVRRVLESIGLKVNRLIRLSYGPFALGTLLPGQV 248

Query: 213 REV 215
            EV
Sbjct: 249 EEV 251


>UniRef50_A3JEU2 Pseudouridine synthase n=2 Tax=Marinobacter RepID=A3JEU2_9ALTE
          Length = 250

 Score =  183 bits (465), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 57/204 (27%), Positives = 89/204 (43%), Gaps = 27/204 (13%)

Query: 20  QVKRFSSQRSTRR-KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAA 75
            V  F++     +   +      I+ +KP   L    D+    T+ + +P    Q ++ A
Sbjct: 55  DVDEFAAVSVNGKTLQQGHCAHYIMLHKPAGYLSATEDD-THPTVLQLLPPGLSQCLHIA 113

Query: 76  GRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG- 134
           GRLDR + GL++LTNNG    +LT PG    K+Y V        D  +    G+      
Sbjct: 114 GRLDRATTGLMILTNNGTWSRQLTLPGMGIAKVYRVTTAYPIGPDTPQRFAEGIWFEYEQ 173

Query: 135 -PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLR 193
             T PA  EL++                    +  ++T+YEGR  QV+RM   VG   + 
Sbjct: 174 LTTAPATLELLEP-------------------TLARLTIYEGRYHQVKRMFHAVGNRVIA 214

Query: 194 LIRYAMGDYSLD-NLANGEWREVT 216
           L R  +G   L+ +LA G +R +T
Sbjct: 215 LHREQIGHLQLNSDLAEGNFRMLT 238


>UniRef50_C7PFL3 Pseudouridine synthase n=3 Tax=Bacteria RepID=C7PFL3_CHIPD
          Length = 389

 Score =  183 bits (465), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 50/209 (23%), Positives = 91/209 (43%), Gaps = 24/209 (11%)

Query: 13  KTSFRNHQVKRFSSQRSTRRKP---ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP- 68
           + +   ++ K   +           + +    +  NKP   +   T+   +  +  F+  
Sbjct: 36  RPAALGNRYKPGDTVEVDGSLITAAKKEKRVYLALNKPPG-ITTTTELHIKDNIISFVNY 94

Query: 69  VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNG 128
            Q ++  GRLD+DSEGL+ LTN+G +  ++ +      K Y V+V      + L  +  G
Sbjct: 95  PQRIFPIGRLDKDSEGLIFLTNDGDIINKILRAANNHEKEYVVRVNKPIDTNFLHQMSQG 154

Query: 129 VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVG 188
           V + D  TLP   ++                         +ITL +G NRQ+RRM  ++G
Sbjct: 155 VPILDTRTLPCKVQMTGRQ-------------------TFRITLTQGLNRQIRRMCEYLG 195

Query: 189 FPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +  + L R  + +  LD L  G+WR +++
Sbjct: 196 YTVVGLQRVRIMNVRLDKLPLGKWRYLSE 224


>UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q1Q0_9BACT
          Length = 260

 Score =  183 bits (464), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 56/184 (30%), Positives = 91/184 (49%), Gaps = 17/184 (9%)

Query: 36  NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGA 93
            +     L NKP D L    DE  R    + I    Q +Y  GRLD+ SEGL+++TN+G 
Sbjct: 59  PEAKIYYLLNKPKDCLCTNYDELNRLRAIDIIKNVKQRLYTIGRLDKQSEGLIIITNDGE 118

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  +L+ P     K Y+++++G  + + + AL++GV L  G T P   + +         
Sbjct: 119 LSNKLSHPKYEVNKTYFIEIDGYLSNETITALQSGVWLAFGKTQPVRIKKM--------- 169

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                  +S   S  ++ L EG+NR++RRM A  G     L R  +G     +L  G++R
Sbjct: 170 ------HRSFKKSRFEMILCEGKNREIRRMLADHGHKVRTLRRIKIGSLCDPDLKVGKYR 223

Query: 214 EVTD 217
           ++T+
Sbjct: 224 KLTE 227


>UniRef50_A6WK95 Pseudouridine synthase n=12 Tax=Gammaproteobacteria
           RepID=A6WK95_SHEB8
          Length = 256

 Score =  183 bits (464), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 56/225 (24%), Positives = 96/225 (42%), Gaps = 29/225 (12%)

Query: 1   MRQFIISENTMQK---TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDE 57
           +R+ ++S             + QV  FS  +      +      ++ +KP  V+    D 
Sbjct: 44  VRELLLSGRVRVDGLIVKDMDRQVDEFSHIQLDEHILQANAPVYVMLHKPIGVVSATKDI 103

Query: 58  AGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
              KT+ + +  +    ++ AGRLD +S GLL+LTN+      L  P  +  K+Y V + 
Sbjct: 104 Q-HKTVIDLLDCEARDELHIAGRLDLNSSGLLLLTNDSRWSDALMSPTHKVDKVYRVTLA 162

Query: 115 GIPTQDALEALRNGVT--LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
              T++ + A   G+     D  T PA   ++ +                      ++TL
Sbjct: 163 NPITEEYIAAFAEGMYFGFEDITTQPAKLVILADNVA-------------------EVTL 203

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           +EG+  Q++RM      P + L R ++GD  LD  LA GE R +T
Sbjct: 204 HEGKYHQIKRMFGRFRNPVVGLHRLSIGDIVLDEKLAPGESRALT 248


>UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1DTU8_SULAA
          Length = 247

 Score =  183 bits (464), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 55/217 (25%), Positives = 95/217 (43%), Gaps = 21/217 (9%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQF-TDEAGRKTLK 64
           ++  T++    +    K          KP  +    +   KP   L     D  GRKTL 
Sbjct: 30  VNGKTVKNLGLKIDPKKDVVEVEGKIVKPT-EKKIYLAIYKPVGYLSAVGKDRFGRKTLT 88

Query: 65  EFIPVQG----VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +F+        ++  GRLD +SEGLL+LTN+G    ++  P     K+Y V+V G  +Q+
Sbjct: 89  DFLNELKIPYKLFPVGRLDYNSEGLLILTNDGEFANKVAHPRNEIKKVYKVKVAGEVSQE 148

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ +  G  L DG   P   +++               ++    +WL + ++ G+ R +
Sbjct: 149 TLKKMEEGTILEDGFFKPDKIKML---------------KREEDGTWLLVEIHSGKKRII 193

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR     G    RLIR  +G   + NL   ++R +++
Sbjct: 194 RRFMDSFGHRVKRLIRVKIGSIDIGNLKPFDYRYLSE 230


>UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZX4_ACIFD
          Length = 254

 Score =  183 bits (464), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 58/193 (30%), Positives = 81/193 (41%), Gaps = 21/193 (10%)

Query: 25  SSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRKTLKEFIPV-QGVYAAGRLDRDS 82
                   +   +  R   L NKP  V+    D  GR T++  +     VY  GRLD DS
Sbjct: 50  DRVEFDGLEIATEEQREYWLLNKPRGVVSSVVDPEGRPTVRSLVATTSRVYPVGRLDVDS 109

Query: 83  EGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAE 142
           EGLL+LTN+G L  +LT P     K Y V V+    +     LR GV ++      +   
Sbjct: 110 EGLLILTNDGPLTYQLTHPRFHVPKEYLVWVDRPVPRRLGRELREGVEVDGELLRASSV- 168

Query: 143 LVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY 202
                              ++    ++I L EGRNRQ+RRM   VG    RL+R  +G  
Sbjct: 169 ------------------GTVGPRLVRIVLTEGRNRQIRRMVGAVGLSVERLVRVRIGPL 210

Query: 203 SLDNLANGEWREV 215
              +L  G  R +
Sbjct: 211 VDPHLPPGVARRL 223


>UniRef50_Q04F57 Pseudouridine synthase n=2 Tax=Oenococcus oeni RepID=Q04F57_OENOB
          Length = 237

 Score =  182 bits (463), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 49/216 (22%), Positives = 97/216 (44%), Gaps = 17/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + K      +V          +K   +     L NKP   +        + +
Sbjct: 30  QVKVNGKIITKL---GKKVSSDDIVYVDNKKINEESFEYYLLNKPAGYVSSNRSYPNQPS 86

Query: 63  LKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + E I  +  +++ GRLD+D+ G+L+LTN+G L  +LT P  R  + Y   V+GI  +D 
Sbjct: 87  VIELIKTKTRIFSVGRLDQDTTGVLLLTNDGELTQKLTHPKHRIKRTYAAWVKGIVNEDE 146

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +E L   +  +     P  A ++             +  +    S ++IT+ EG+N +++
Sbjct: 147 IEQLTKPIRFDGEIYFPQAARIL-------------KVDQKRQESLIEITIAEGKNHEIK 193

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           ++   +G P ++L R      ++ NL  G+ R +++
Sbjct: 194 KILDFIGHPVIKLNRDMFDGITIGNLKKGQHRALSE 229


>UniRef50_UPI0001745920 putative pseudouridylate synthase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001745920
          Length = 235

 Score =  182 bits (463), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 63/205 (30%), Positives = 94/205 (45%), Gaps = 27/205 (13%)

Query: 18  NHQVKRFSSQ-RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIP---VQGVY 73
            H+V RFS+         E +    I+ +KP   L    D     T+ + I     + ++
Sbjct: 38  QHEVDRFSTVWLDDTLVQEGESALYIMLHKPVGYLSATRDPQ-HPTVIDLIDHPARETLH 96

Query: 74  AAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTL-- 131
            AGRLDR S GLL+LTN+G    RLT+PG++  K+Y V+       +A+E    G     
Sbjct: 97  IAGRLDRSSSGLLLLTNDGRWSRRLTEPGEKVDKVYLVETAEPIAPEAVELFAKGFYFHT 156

Query: 132 NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPT 191
            D  TLPA   ++ E                      ++TL+EGR  Q++RM   VG   
Sbjct: 157 EDLTTLPAELGILGE-------------------RLARVTLHEGRYHQIKRMFHRVGNRV 197

Query: 192 LRLIRYAMGDYSLD-NLANGEWREV 215
           + L R ++G   L   L  G+WRE+
Sbjct: 198 ISLHRESIGSLVLPVELFPGQWREI 222


>UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae RepID=C6VP86_LACPJ
          Length = 246

 Score =  182 bits (462), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 60/199 (30%), Positives = 92/199 (46%), Gaps = 20/199 (10%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV----QGVYAAGRLDR 80
            +      +   Q     + NKP  V+   TD A  KT+ +          ++  GRLD+
Sbjct: 46  DTVFLDDVQVRYQQYFYYVMNKPVGVITATTDSAA-KTVMDLFNTTDFRDDLFPVGRLDK 104

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL-PA 139
           D+EG+LV+TN+GAL   L  P     K+Y  +V G  T   L    +G+TL DG  L PA
Sbjct: 105 DTEGILVITNDGALSHDLLSPNHHVTKVYEAEVTGEITAAQLANFNDGITLKDGTELQPA 164

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
            AE+V             +  +    + ++I ++EG+  QV+RM   +G   + L R   
Sbjct: 165 QAEIV-------------QFHEIENFTTIRIMIHEGKYHQVKRMVGTLGERVVGLRRIKF 211

Query: 200 GDYSLD-NLANGEWREVTD 217
           G  +L   L  G +R +TD
Sbjct: 212 GSLTLPVGLLAGNYRALTD 230


>UniRef50_B8DUD9 Pseudouridine synthase n=8 Tax=Bifidobacterium RepID=B8DUD9_BIFA0
          Length = 257

 Score =  182 bits (462), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 61/210 (29%), Positives = 96/210 (45%), Gaps = 31/210 (14%)

Query: 23  RFSSQRSTRRKPENQPTRV-------------ILFNKPYDVLPQFTDEAGRKTLKEFI-- 67
              ++  TR  P+ Q  RV             +  NKP  VL    D  GR TL++ +  
Sbjct: 50  ELVTELGTRVDPKRQQVRVDGSRIRLNPRHITLALNKPRKVLSTMDDPKGRYTLRDIVGD 109

Query: 68  PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEAL-R 126
             + ++  GRLD DSEGL+++TN+G L   +  P     K Y   +EG  +      L R
Sbjct: 110 KYERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATLEGHMSGTVCRRLVR 169

Query: 127 NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAH 186
            GV L+DG        ++D                +   + +K+ L+ GRNR VRR+   
Sbjct: 170 TGVQLDDGWIKLDHCSIID---------------SNRDQTIVKVVLHSGRNRIVRRIFGA 214

Query: 187 VGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +GFP  RL+R  +G   L ++ +G +R ++
Sbjct: 215 IGFPVKRLVRTQIGPIKLGDIKSGSYRVLS 244


>UniRef50_C0EB54 Pseudouridine synthase n=1 Tax=Clostridium methylpentosum DSM 5476
           RepID=C0EB54_9CLOT
          Length = 248

 Score =  182 bits (462), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 54/198 (27%), Positives = 89/198 (44%), Gaps = 23/198 (11%)

Query: 25  SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQ----GVYAAGRLDR 80
              R   R    Q    ++ NKP  V+    D+  R T+ + +P +    G++ AGRLDR
Sbjct: 48  DEIRVDGRVYGYQEHLYLMLNKPQGVVSATDDKVHR-TVLDLVPPELRRRGLFPAGRLDR 106

Query: 81  DSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG-PTLPA 139
           D+ G +++T++G     +  P     K Y   ++G   ++ L  L  GV L DG    PA
Sbjct: 107 DTVGFVLITDDGEFAHNILSPRHHVPKTYEAGLDGPIGENELSVLAQGVVLGDGTKCRPA 166

Query: 140 GAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM 199
              ++                +S     ++I + EGR  Q++RM A VG   L L R  +
Sbjct: 167 ELTVL----------------QSGERPLIQIVIVEGRYHQIKRMFAAVGRRVLTLKRTKI 210

Query: 200 GDYSLD-NLANGEWREVT 216
           G  +LD +L  G+   ++
Sbjct: 211 GGLALDPSLKEGDCIAIS 228


>UniRef50_Q87NB7 Ribosomal large subunit pseudouridine synthase B n=17 Tax=Bacteria
           RepID=RLUB_VIBPA
          Length = 312

 Score =  182 bits (462), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 56/200 (28%), Positives = 80/200 (40%), Gaps = 19/200 (9%)

Query: 20  QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYAAG 76
            V R      + +  E    RV+ + KP   L    D  GR+T+ + +P        + G
Sbjct: 47  SVVRIDGHIVSAKVQEEVICRVLAYYKPEGELCTRHDPEGRRTVFDRLPKIRGSRWISVG 106

Query: 77  RLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPT 136
           RLD ++ GLL+ T +G L  RL  P ++  + Y V+V G  T+  +  L  GV L DG  
Sbjct: 107 RLDANTSGLLLFTTDGELANRLMHPSRQVEREYLVRVFGEVTEQKVRNLVKGVELEDGLA 166

Query: 137 LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIR 196
                                            + + EGRNR+VRR+         RL R
Sbjct: 167 RFEDVVYAGGEGM---------------NHTFYVVINEGRNREVRRLWESQECTVSRLKR 211

Query: 197 YAMGDYSLD-NLANGEWREV 215
              GD  LD  L  G W E+
Sbjct: 212 VRYGDIFLDKKLPRGGWMEL 231


>UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9AXM1_HERA2
          Length = 728

 Score =  181 bits (461), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 67/212 (31%), Positives = 104/212 (49%), Gaps = 17/212 (8%)

Query: 6   ISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKE 65
           ++    ++   +    K        +  P  +    +L +KP  V+    D  GR+T+ +
Sbjct: 30  VNGRVQRELGTQIDPDKDDIRVDGEQITPPTE-LHYVLLHKPSSVMTTLHDPEGRQTVAD 88

Query: 66  FIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEA 124
            +     ++  GRLD DSEGLL+LT++G L  RLT P     K Y   +   P+ + L  
Sbjct: 89  LVKSHNRLFPVGRLDYDSEGLLLLTDDGDLTFRLTHPSFEVEKEYQALLNQTPSVEQLRE 148

Query: 125 LRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMT 184
            RNGV L+DG T PA  EL++E A                 +W+++ ++EGRNRQ+RR+ 
Sbjct: 149 WRNGVELDDGKTAPAWIELLNETA---------------DGTWVRVVIHEGRNRQIRRVA 193

Query: 185 AHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
             +G    RLIR   G  +L  L  G+WR +T
Sbjct: 194 EALGLEVRRLIRLREGPLTLGELQAGQWRALT 225


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E...   256   4e-67
UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadale...   244   2e-63
UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3...   243   5e-63
UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B...   240   2e-62
UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E...   240   2e-62
UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta...   238   1e-61
UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae ...   238   2e-61
UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyr...   237   2e-61
UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=...   236   3e-61
UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibac...   236   5e-61
UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E...   236   6e-61
UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E...   235   8e-61
UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae...   234   1e-60
UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E...   234   1e-60
UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter ferme...   234   1e-60
UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=...   232   5e-60
UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wo...   232   7e-60
UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   231   2e-59
UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   230   2e-59
UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B...   230   2e-59
UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   229   3e-59
UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium c...   229   4e-59
UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8...   229   4e-59
UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E...   229   5e-59
UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q2...   228   8e-59
UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia ...   228   8e-59
UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gin...   228   1e-58
UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   228   1e-58
UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9...   226   3e-58
UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroid...   226   4e-58
UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   226   5e-58
UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter hepari...   225   6e-58
UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0...   225   9e-58
UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   225   1e-57
UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax...   224   2e-57
UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3...   223   3e-57
UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr06...   223   3e-57
UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_14...   223   3e-57
UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula m...   223   4e-57
UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandens...   223   4e-57
UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales ...   222   6e-57
UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=...   221   9e-57
UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organism...   221   1e-56
UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A...   220   2e-56
UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales Re...   220   2e-56
UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testost...   220   3e-56
UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella dranco...   220   3e-56
UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   220   3e-56
UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uen...   219   4e-56
UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   219   6e-56
UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1...   219   6e-56
UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   218   8e-56
UniRef50_P0AA45 Ribosomal small subunit pseudouridine synthase A...   218   9e-56
UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter the...   218   1e-55
UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes Rep...   218   1e-55
UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   218   1e-55
UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae Rep...   218   1e-55
UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5...   217   2e-55
UniRef50_A3HY40 Pseudouridine synthase n=1 Tax=Algoriphagus sp. ...   217   2e-55
UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepI...   217   2e-55
UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marin...   217   2e-55
UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5...   217   2e-55
UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q...   217   3e-55
UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   217   3e-55
UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q...   216   3e-55
UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   216   3e-55
UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae...   216   3e-55
UniRef50_Q38VQ0 Pseudouridine synthase n=6 Tax=Lactobacillus Rep...   216   4e-55
UniRef50_Q12AB3 Pseudouridine synthase n=8 Tax=Proteobacteria Re...   216   4e-55
UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limn...   216   4e-55
UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytop...   216   4e-55
UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp....   215   6e-55
UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   215   7e-55
UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium r...   215   8e-55
UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine...   215   9e-55
UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (...   215   9e-55
UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q0...   215   9e-55
UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapol...   215   1e-54
UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C...   214   1e-54
UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine syn...   214   1e-54
UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredi...   214   1e-54
UniRef50_Q8ZGM2 Ribosomal small subunit pseudouridine synthase A...   214   1e-54
UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae Re...   214   2e-54
UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   214   2e-54
UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales R...   214   2e-54
UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrional...   214   2e-54
UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q...   214   2e-54
UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   214   2e-54
UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   214   2e-54
UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium Re...   214   2e-54
UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutac...   213   3e-54
UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi A...   213   3e-54
UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1...   213   3e-54
UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacter...   213   4e-54
UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium Rep...   213   5e-54
UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae ...   212   6e-54
UniRef50_B4D966 Pseudouridine synthase n=1 Tax=Chthoniobacter fl...   212   6e-54
UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6...   212   7e-54
UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomona...   212   7e-54
UniRef50_A1WE21 Pseudouridine synthase n=1 Tax=Verminephrobacter...   211   9e-54
UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termit...   211   1e-53
UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae...   211   1e-53
UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   211   1e-53
UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   211   1e-53
UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueg...   211   2e-53
UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   211   2e-53
UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   211   2e-53
UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae Rep...   211   2e-53
UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi...   211   2e-53
UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   210   2e-53
UniRef50_C9LMF3 Ribosomal small subunit pseudouridine synthase A...   210   2e-53
UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepI...   210   3e-53
UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin51...   210   3e-53
UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72...   209   4e-53
UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   209   4e-53
UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumo...   209   4e-53
UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   209   4e-53
UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   209   5e-53
UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ...   209   5e-53
UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales R...   209   6e-53
UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   209   6e-53
UniRef50_B2V6W2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B2...   209   7e-53
UniRef50_Q1LLR3 Pseudouridine synthase n=15 Tax=Proteobacteria R...   209   7e-53
UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacter...   209   8e-53
UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus Re...   208   1e-52
UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succi...   208   1e-52
UniRef50_C3X1E1 Pseudouridine synthase n=2 Tax=Oxalobacter formi...   208   1e-52
UniRef50_C6X4T2 Pseudouridine synthase n=2 Tax=Flavobacteriaceae...   208   1e-52
UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria Rep...   208   1e-52
UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine syn...   207   1e-52
UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3...   207   2e-52
UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae Rep...   207   2e-52
UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gas...   207   2e-52
UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria R...   207   2e-52
UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterinea...   207   2e-52
UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   207   2e-52
UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID...   207   3e-52
UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales Rep...   207   3e-52
UniRef50_A9KPL1 Pseudouridine synthase n=63 Tax=Bacteria RepID=A...   206   3e-52
UniRef50_C7I043 Pseudouridine synthase n=4 Tax=Proteobacteria Re...   206   4e-52
UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=...   206   4e-52
UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteri...   206   5e-52
UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium R...   206   6e-52
UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus Re...   205   8e-52
UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna ...   205   8e-52
UniRef50_Q04F57 Pseudouridine synthase n=2 Tax=Oenococcus oeni R...   205   9e-52
UniRef50_C3BQR1 Pseudouridine synthase n=3 Tax=Bacillus RepID=C3...   205   9e-52
UniRef50_A3JIZ1 Pseudouridine synthase n=1 Tax=Marinobacter sp. ...   205   1e-51
UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales Rep...   205   1e-51
UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=...   204   1e-51
UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   204   1e-51
UniRef50_A9KNY1 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   204   1e-51
UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   204   1e-51
UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdello...   204   1e-51
UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID...   204   2e-51
UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacter...   204   2e-51
UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria ...   204   2e-51
UniRef50_C7PFL3 Pseudouridine synthase n=3 Tax=Bacteria RepID=C7...   204   2e-51
UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae Re...   203   3e-51
UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacte...   203   3e-51
UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria Re...   203   3e-51
UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID...   203   3e-51
UniRef50_C5CXG1 Pseudouridine synthase n=4 Tax=Comamonadaceae Re...   203   3e-51
UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=...   203   4e-51
UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodi...   202   4e-51
UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflex...   202   4e-51
UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter rube...   202   5e-51
UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepI...   202   5e-51
UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actino...   202   6e-51
UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (c...   202   6e-51
UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis...   202   6e-51
UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter Re...   202   6e-51
UniRef50_C8PSZ6 Ribosomal large subunit pseudouridine synthase B...   202   7e-51
UniRef50_UPI0001C37AA4 16s pseudouridylate synthase n=2 Tax=Rumi...   202   8e-51
UniRef50_A8ZRV1 Pseudouridine synthase n=3 Tax=Desulfobacteracea...   202   8e-51
UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1...   202   9e-51
UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacter...   201   1e-50
UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   201   1e-50
UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5...   201   1e-50
UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K...   201   2e-50
UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas Rep...   201   2e-50
UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella el...   201   2e-50
UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0...   201   2e-50
UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indi...   201   2e-50
UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. ...   200   2e-50
UniRef50_A8S8D3 Pseudouridine synthase n=1 Tax=Faecalibacterium ...   200   2e-50
UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracel...   200   2e-50
UniRef50_C2KV26 Pseudouridylate synthase n=1 Tax=Oribacterium si...   200   3e-50
UniRef50_P45104 Ribosomal large subunit pseudouridine synthase B...   200   3e-50
UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales R...   200   4e-50
UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae ...   199   4e-50
UniRef50_Q2W4E4 Pseudouridine synthase n=20 Tax=cellular organis...   199   4e-50
UniRef50_D1N1S2 Pseudouridine synthase n=1 Tax=Victivallis vaden...   199   4e-50
UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum fe...   199   4e-50
UniRef50_A5TW76 Pseudouridine synthase n=11 Tax=Fusobacterium Re...   199   4e-50
UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr03...   199   5e-50
UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organism...   199   5e-50
UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   199   5e-50
UniRef50_C1DA59 Pseudouridine synthase n=6 Tax=Betaproteobacteri...   199   6e-50
UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacte...   199   7e-50
UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   199   7e-50
UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   199   7e-50
UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter Re...   198   8e-50
UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID...   198   1e-49
UniRef50_C0W3E8 Pseudouridine synthase n=1 Tax=Actinomyces uroge...   198   1e-49
UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii ...   198   1e-49
UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus...   198   1e-49
UniRef50_Q2NSN0 Pseudouridine synthase n=7 Tax=Gammaproteobacter...   198   1e-49
UniRef50_Q1H048 Pseudouridine synthase n=4 Tax=Betaproteobacteri...   198   1e-49
UniRef50_D0SB72 Pseudouridine synthase n=5 Tax=Acinetobacter Rep...   197   2e-49
UniRef50_Q9HZ55 Ribosomal large subunit pseudouridine synthase B...   197   2e-49
UniRef50_C9RMB6 Pseudouridine synthase n=1 Tax=Fibrobacter succi...   197   2e-49
UniRef50_A1U6Q2 Pseudouridine synthase n=4 Tax=Gammaproteobacter...   197   3e-49
UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E...   197   3e-49
UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus...   197   3e-49
UniRef50_C7NBL1 Pseudouridine synthase n=3 Tax=Leptotrichia RepI...   196   3e-49
UniRef50_O32068 Uncharacterized RNA pseudouridine synthase ytzG ...   196   4e-49
UniRef50_B2HUK5 Pseudouridine synthase n=9 Tax=Gammaproteobacter...   196   5e-49
UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus m...   196   5e-49
UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alex...   196   5e-49
UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2...   196   6e-49
UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenen...   196   6e-49
UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silv...   196   6e-49
UniRef50_Q3IC94 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q3...   196   6e-49
UniRef50_Q14P18 Pseudouridine synthase n=2 Tax=Mollicutes RepID=...   195   8e-49
UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis exc...   195   8e-49
UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   195   8e-49
UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B...   195   9e-49
UniRef50_A5WGV6 Pseudouridine synthase n=7 Tax=Moraxellaceae Rep...   195   1e-48
UniRef50_B9JSE7 Ribosomal large subunit pseudouridine synthase B...   195   1e-48
UniRef50_C0EB54 Pseudouridine synthase n=1 Tax=Clostridium methy...   194   1e-48
UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae ...   194   1e-48
UniRef50_Q1RJR2 Uncharacterized RNA pseudouridine synthase RBE_0...   194   1e-48
UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9...   194   1e-48
UniRef50_A0PYR9 Pseudouridine synthase n=9 Tax=Clostridium RepID...   194   1e-48
UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vag...   194   2e-48
UniRef50_B0B8U9 Pseudouridine synthase n=10 Tax=Chlamydiales Rep...   194   2e-48
UniRef50_A6WK95 Pseudouridine synthase n=12 Tax=Gammaproteobacte...   194   2e-48
UniRef50_Q21JF0 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   194   2e-48
UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q1...   194   2e-48
UniRef50_C7NDY8 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   194   2e-48
UniRef50_A6DMJ6 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   194   2e-48
UniRef50_C7H4Z6 Pseudouridine synthase n=1 Tax=Faecalibacterium ...   194   2e-48
UniRef50_A8U4V7 Pseudouridine synthase n=10 Tax=Lactobacillales ...   194   2e-48
UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovib...   193   3e-48
UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus...   193   4e-48
UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum v...   193   4e-48
UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium fe...   192   5e-48
UniRef50_D1R854 Pseudouridine synthase n=4 Tax=Chlamydiales RepI...   192   5e-48
UniRef50_C0QWY7 Pseudouridine synthase n=2 Tax=Brachyspira RepID...   192   5e-48

Sequences not found previously or not previously below threshold:

>UniRef50_Q8ZPZ1 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Enterobacteriaceae RepID=RLUE_SALTY
          Length = 221

 Score =  256 bits (654), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 179/215 (83%), Positives = 198/215 (92%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           MRQ I SENTMQKTSFRNH VKRFSS+++++ + ENQP RV+LFNKPYDVLPQFTDEAGR
Sbjct: 1   MRQLISSENTMQKTSFRNHYVKRFSSRQASKSRKENQPKRVVLFNKPYDVLPQFTDEAGR 60

Query: 61  KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +TLK+FIPVQGVYAAGRLDRDSEGLLVLTN+GALQARLTQPGKRTGKIYYVQVEGIP   
Sbjct: 61  RTLKDFIPVQGVYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGIPDNA 120

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           AL+ALR GVTLNDGPTLPAG E+V EP WLWPR PPIRERK+IPTSWLK+TLYEGRNRQV
Sbjct: 121 ALQALRTGVTLNDGPTLPAGIEIVAEPDWLWPRTPPIRERKNIPTSWLKVTLYEGRNRQV 180

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RRMTAHVG PTLRLIRY+MGDY+L+ L NG+WRE+
Sbjct: 181 RRMTAHVGHPTLRLIRYSMGDYTLNGLDNGQWREI 215


>UniRef50_B3E7C4 Pseudouridine synthase n=6 Tax=Desulfuromonadales
           RepID=B3E7C4_GEOLS
          Length = 274

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 101/217 (46%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +   +    K         +  +  +    +L +KP   +    D  GR+
Sbjct: 28  RVTVNGQVVTELGSKADPAK--DLIALDGQPVKPAETFYYVLLHKPAGYVTSLKDPQGRQ 85

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            + E +    + ++  GRLD +SEGLL+LTN+GA   RL  P  +  K Y+V+V G    
Sbjct: 86  LVTELVKDVGERLFPVGRLDYNSEGLLLLTNDGAWANRLMHPRHQVDKEYHVRVRGKIDP 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             ++ L +GV L DGPT      L+               +      WL +T+ EGRNRQ
Sbjct: 146 QQIKKLADGVELEDGPTGATTVRLL---------------KNDQSNDWLSVTIREGRNRQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM A VG   +RL R   G+ +L  L  GE+R ++
Sbjct: 191 VRRMCAAVGLFVVRLRRIRYGNLTLGGLQPGEYRLLS 227


>UniRef50_B3U4L2 Pseudouridine synthase n=3 Tax=Bacteria RepID=B3U4L2_9BACT
          Length = 420

 Score =  243 bits (620), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 20/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I+ + +++   +    +     +   +     QP   ++ NKP +V+    D  GR 
Sbjct: 28  RVTINGSVVKELGTKVDPAR--DHVKVDGKHLRAAQPYVYLILNKPKNVMSTLDDPEGRP 85

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+K+ +      V+  GRLD DSEGL++LTN+G L   L  P     K Y ++V+G+   
Sbjct: 86  TVKDLLHGVTVRVFPVGRLDFDSEGLMLLTNHGDLAQALLHPRYHVPKTYLIKVKGVLDD 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             +EAL  GV L DG T PA  + V                ++   SWL++T++EGR  Q
Sbjct: 146 AKIEALERGVKLEDGFTAPAKVKKVS---------------RAESNSWLEVTIHEGRKHQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           V+RM   VG   ++L+R  MG   L +LA  E+R +TD
Sbjct: 191 VKRMVEAVGHSVIKLVRVRMGPLLLGDLAPREYRFLTD 228


>UniRef50_B0TFD8 Pseudouridine synthase n=18 Tax=Bacteria RepID=B0TFD8_HELMI
          Length = 333

 Score =  240 bits (614), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 70/217 (32%), Positives = 102/217 (47%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I+   +++   R    +         R  +  +        KP  V+    D  GR+
Sbjct: 31  RVRINGTVVREQGVRVDGAR--DVIEVDGRILKRREAPLYYALYKPRGVVTTCKDPQGRQ 88

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+   +    + VY  GRLDRD+EGLL+LTN+G L  RLT P     K Y  ++ G  + 
Sbjct: 89  TVIGLLSGVNERVYPVGRLDRDTEGLLLLTNDGQLAFRLTHPRFGVEKTYRARLRGDVSA 148

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            AL+AL  GV L DG T PA   L+               R+    +W++I ++EGR RQ
Sbjct: 149 GALKALAEGVQLEDGVTAPAQVRLL---------------RREGDATWIEIKIHEGRKRQ 193

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +RRM   +G P + L R A G  +L  L  GE R +T
Sbjct: 194 IRRMGDAIGHPVIDLERIAFGPITLGKLKPGEVRPLT 230


>UniRef50_Q9F855 Ribosomal large subunit pseudouridine synthase E n=107 Tax=Bacteria
           RepID=RLUE_VIBCH
          Length = 241

 Score =  240 bits (614), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 127/186 (68%), Positives = 150/186 (80%), Gaps = 1/186 (0%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTN 90
           +R       +VILFNKPYD L QFTD  GRKTL ++IP++ VYAAGRLDRDSEGLL+LTN
Sbjct: 56  KRPLSPAERKVILFNKPYDTLSQFTDGDGRKTLADYIPIKDVYAAGRLDRDSEGLLILTN 115

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           +G LQARLTQP  +  K Y+VQVEG P +  LEALR+GVTL DGPTLPA  +++ EP  L
Sbjct: 116 DGILQARLTQPQSKAPKTYWVQVEGSPQESDLEALRHGVTLKDGPTLPAKVDIMPEPT-L 174

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
           WPRNPP+R R +IPT+WL ITL EGRNRQVRRMTAH+GFPTLRLIRY+MGD++L +L  G
Sbjct: 175 WPRNPPVRFRAAIPTTWLAITLMEGRNRQVRRMTAHIGFPTLRLIRYSMGDWNLGDLQPG 234

Query: 211 EWREVT 216
           EWREVT
Sbjct: 235 EWREVT 240


>UniRef50_C8WGQ8 Pseudouridine synthase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WGQ8_EGGLE
          Length = 282

 Score =  238 bits (607), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 64/233 (27%), Positives = 100/233 (42%), Gaps = 22/233 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +   +                         I+ +KP   +   +D  GR+
Sbjct: 36  RVTVNGKVVTELGSKV--DPLVDEVAVDGAVVRLADGPVTIMLHKPAGFVTTMSDPQGRR 93

Query: 62  TLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ E +P +    ++  GRLD D+ GLL+ + +G L   L  P     K Y   VEG PT
Sbjct: 94  TVAELVPTERYPGLFPIGRLDFDTTGLLLFSTDGELGNGLLHPKHHVTKRYLACVEGRPT 153

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDE----------------PAWLWPRNPPIRERKS 162
           +  L  LR G+ L+DGPT PA   +V+                 P         + E ++
Sbjct: 154 ERDLALLRRGIELDDGPTQPADVRVVEGGAARHAERLLEIPAAVPPRSSKEYAAVCEGRA 213

Query: 163 IPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
              S +++ + EGR RQV+RM A VG P L L R + G   L +L  G WR +
Sbjct: 214 TRRSIVRLGIREGRKRQVKRMLAAVGHPVLALHRDSFGPLELGDLPRGAWRAL 266


>UniRef50_B3GZS7 Pseudouridine synthase n=10 Tax=Pasteurellaceae RepID=B3GZS7_ACTP7
          Length = 232

 Score =  238 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 109/210 (51%), Positives = 139/210 (66%), Gaps = 4/210 (1%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKPE----NQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI 67
           QK   R+   K     R+ +R  +     + T V+LFNKP+DVL QFTDE GR+TLK+FI
Sbjct: 9   QKNKPRSATNKPNLQNRTKKRPLKLQLSFEDTVVVLFNKPFDVLTQFTDEQGRQTLKDFI 68

Query: 68  PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRN 127
           P+  +Y  GRLDRDSEGLL+LTNNG +Q RL  P     K Y  QVEGIP    L  L  
Sbjct: 69  PIPQIYPVGRLDRDSEGLLLLTNNGEIQHRLANPKFEKQKTYLAQVEGIPQAADLAKLEK 128

Query: 128 GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
           GV L DG T PA A+ +  P + W   P IRERK+IPTSW+++ ++EG+NRQVRRMTAH+
Sbjct: 129 GVELKDGLTKPAKAKAISAPNYEWQTAPKIRERKTIPTSWIELKIHEGKNRQVRRMTAHI 188

Query: 188 GFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           GFPTLRLIR  +G + L  L +GE+R + +
Sbjct: 189 GFPTLRLIRIGLGQFQLGELNSGEYRVLDE 218


>UniRef50_C7ICF2 Pseudouridine synthase n=1 Tax=Clostridium papyrosolvens DSM 2782
           RepID=C7ICF2_9CLOT
          Length = 235

 Score =  237 bits (606), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 21/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   ++        V          +    +     I+ NKP   +    D+ GR 
Sbjct: 29  RVAVNNVIIEN---MGATVTCNDVVTVDGKPVTTEEAKVYIMLNKPVGYVSTSKDQFGRP 85

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            + + +    + +Y  GRLD D+ GL++LTN+G    RLT P     K+Y   + G P +
Sbjct: 86  AVIDLVKDAGKRLYPVGRLDYDTSGLILLTNDGDFTYRLTHPKHEVNKVYEAVISGFPDK 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + +     G+ ++D  T PA  E++++                   + ++IT++EG+NRQ
Sbjct: 146 NEITRFETGLKIDDYQTSPAEFEVLNKKGI---------------NTLVRITIHEGKNRQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VR+M   +G   L L R  +G  +L+NL  G+WR ++D
Sbjct: 191 VRKMCEAIGHKVLTLKRIQIGPIALENLPEGKWRHLSD 228


>UniRef50_A4J3M3 Pseudouridine synthase n=167 Tax=Bacteria RepID=A4J3M3_DESRM
          Length = 309

 Score =  236 bits (604), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 75/217 (34%), Positives = 108/217 (49%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           Q  ++  T+ +   +    K         +     +    +L NKP   +   +DE  RK
Sbjct: 28  QVKVNGKTVTEMGLKVDPTK--DKIEVKGKPLPPLEKKVYLLMNKPRGYVTTLSDERDRK 85

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +    Q VY  GRLD DSEGLL+LTN+G L   LT P  +  K Y  +V+GIP  
Sbjct: 86  TVVDLLKGVEQRVYPVGRLDYDSEGLLLLTNDGELTQALTHPKHKVKKTYLAKVDGIPET 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+A+  G+ L DGPT PA   L                      + L+I+++EGRNRQ
Sbjct: 146 EELKAMAKGLVLEDGPTAPADVRL---------------AGTGDNRALLEISIHEGRNRQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM  H+G+  LRL R  +G   L +L +GE R +T
Sbjct: 191 VRRMCEHIGYKVLRLRRTRIGTLELGSLKSGEVRALT 227


>UniRef50_UPI0001693918 pseudouridylate synthase n=1 Tax=Paenibacillus larvae subsp. larvae
           BRL-230010 RepID=UPI0001693918
          Length = 249

 Score =  236 bits (602), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 74/215 (34%), Positives = 104/215 (48%), Gaps = 17/215 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++  +     + +        +   R  +NQ    ILFNKP  V+   +D  GR+ 
Sbjct: 28  RVEVNDKVVSTLGVKVNP--HQDVIKVDGRAIQNQEKIYILFNKPKGVITSVSDPEGRRV 85

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + +F+    + VY  GRLD D+EGLL+LTN+G     +T P     K Y+  V+G+P   
Sbjct: 86  VGDFLKGIKERVYPVGRLDYDTEGLLILTNDGEFANMVTHPRHHVSKTYHATVKGVPHGS 145

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            LE LR GV L DG T PA  E  D                    S + IT+YEG+NRQV
Sbjct: 146 VLEKLREGVKLEDGMTAPAEVEYHD-------------IDPDKKQSVISITIYEGKNRQV 192

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RRM   VG+P  RL R   G   L  L  G++R +
Sbjct: 193 RRMFEAVGYPVTRLKRVKFGSIPLVGLPRGKFRRM 227


>UniRef50_Q9CKK7 Ribosomal large subunit pseudouridine synthase E n=61 Tax=Bacteria
           RepID=RLUE_PASMU
          Length = 241

 Score =  236 bits (602), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 120/187 (64%), Positives = 142/187 (75%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTN 90
           ++      T+VILFNKPYDVL QF+DE GR TLK FIP+  VY AGRLDRDSEGL++LTN
Sbjct: 41  KKTVNFAETQVILFNKPYDVLTQFSDEEGRATLKAFIPIPHVYPAGRLDRDSEGLVLLTN 100

Query: 91  NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWL 150
           NG +Q RL  P   T K Y+ QVEGIP +  L  LR GV LNDG TLPA   LV EP WL
Sbjct: 101 NGEIQHRLAVPKFNTEKTYFAQVEGIPQETDLAQLRQGVVLNDGKTLPAKVRLVPEPNWL 160

Query: 151 WPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANG 210
           W RNPPIRERK IPTSWL+I ++EGRNRQVRRMTAH+GFPTLRLIRY M  ++L NL  G
Sbjct: 161 WQRNPPIRERKQIPTSWLEIKIHEGRNRQVRRMTAHIGFPTLRLIRYQMALFNLANLEQG 220

Query: 211 EWREVTD 217
           ++R++++
Sbjct: 221 QYRQLSE 227


>UniRef50_Q1QUR9 Ribosomal large subunit pseudouridine synthase E n=26 Tax=Bacteria
           RepID=Q1QUR9_CHRSD
          Length = 257

 Score =  235 bits (600), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 104/183 (56%), Positives = 129/183 (70%), Gaps = 1/183 (0%)

Query: 34  PENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
           P    + + L +KPY +L QFTD  GR TL E I V  +Y AGRLD DSEGLL+LT +GA
Sbjct: 55  PRPPMSSLYLLHKPYQMLSQFTDTRGRATLAEAIDVPDIYPAGRLDYDSEGLLLLTGDGA 114

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L  R++ P  +  K Y+VQVEG P   AL+ALR GVTL DGPT PA    ++ P  + PR
Sbjct: 115 LAHRISHPRHKQPKTYWVQVEGEPEPAALQALRQGVTLRDGPTRPAKVRRLESPD-VAPR 173

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           +PP+R R+++PT+WL++TL EGRNRQVRRMTAHVG PTLRLIR A+G + L  LA GEWR
Sbjct: 174 HPPVRHREAVPTAWLELTLSEGRNRQVRRMTAHVGHPTLRLIRVAIGSWHLAGLAPGEWR 233

Query: 214 EVT 216
             T
Sbjct: 234 RET 236


>UniRef50_C8WAL4 Pseudouridine synthase n=7 Tax=Coriobacteriaceae RepID=C8WAL4_ATOPD
          Length = 279

 Score =  234 bits (599), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 60/221 (27%), Positives = 97/221 (43%), Gaps = 7/221 (3%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   +   +    +          +    ++ NKP   L    D  GR T
Sbjct: 34  RVTVNGQVVTELGSKVDPLVDVVAVDGVVCSIA-EKPVYLMLNKPAGYLTTMKDPQGRPT 92

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +P     G++  GRLD D+ GLL  T +G +   L  P K   K Y   V G PT+
Sbjct: 93  IVDMVPTDTYPGLFPVGRLDMDTTGLLFFTTDGQMAQELLHPSKHVWKHYVAHVVGTPTE 152

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSI---PTSWLKITLYEGR 176
           + L  LR G+ L DGP  PA  E++ +   +     P    K+    P + + +T+ EGR
Sbjct: 153 EQLNRLREGIELEDGPAAPAEVEIISDDVKMKNLLAPQGLGKTGGGEPNALVSVTIREGR 212

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
             QV++M   +    L L R   G   L  +  GEWR +T+
Sbjct: 213 KHQVKKMLLAIHHRVLALHRDTFGPLHLTRVKEGEWRLLTE 253


>UniRef50_Q9HX48 Ribosomal large subunit pseudouridine synthase E n=30
           Tax=Proteobacteria RepID=RLUE_PSEAE
          Length = 189

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 118/183 (64%), Positives = 139/183 (75%), Gaps = 1/183 (0%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNG 92
           K      +++LFNKP+DVL QF DE GR TLK+FIPV GVY AGRLDRDSEGLL+LTN+G
Sbjct: 3   KAPPSEPKLLLFNKPFDVLTQFNDEQGRSTLKDFIPVPGVYPAGRLDRDSEGLLLLTNDG 62

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            LQAR+  P  +  K Y+VQVEG P ++ L  LR GVTLNDGPTLPA A L+DEP  LW 
Sbjct: 63  RLQARIADPRHKLPKTYWVQVEGTPDEEQLRRLREGVTLNDGPTLPAEARLLDEPT-LWE 121

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           R PP+R RKS+PT WL++ + EGRNRQVRRMTA VG PTLRL+R  +G +SLD L  GEW
Sbjct: 122 RVPPVRFRKSVPTHWLELVIREGRNRQVRRMTAAVGLPTLRLVRVRIGPWSLDGLGLGEW 181

Query: 213 REV 215
           REV
Sbjct: 182 REV 184


>UniRef50_C6VXU0 Pseudouridine synthase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6VXU0_DYAFD
          Length = 555

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 63/218 (28%), Positives = 101/218 (46%), Gaps = 23/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + +     ++V+     +  ++    +    IL NKP D +    D   RKT
Sbjct: 348 QISVNGKIVTE---MGYKVRPTDVVKYGKKALNPEKMVYILINKPKDYITTTDDPEERKT 404

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + I     + VY  GRLDR++ GLL+LTN+G L  +LT P     KIY  +++   T 
Sbjct: 405 VLDIIAGACSERVYPVGRLDRNTTGLLLLTNDGELAEKLTHPSSGIKKIYQAELDKPITT 464

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +  E L+ GV L DG   P    LV   A +                 + + ++ GRNR 
Sbjct: 465 EDFEQLKAGVELEDGFIRPDEVGLVTPDAQV-----------------VGLEIHSGRNRI 507

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRRM  H+G+   +L R      +  +L  G+WR +T+
Sbjct: 508 VRRMFEHLGYEVQKLDRTVFAGLNKKDLPRGKWRFLTE 545


>UniRef50_Q65HX7 Pseudouridine synthase n=5 Tax=Firmicutes RepID=Q65HX7_BACLD
          Length = 244

 Score =  232 bits (593), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++  T+++      +V           + E++     L  KP  V+    D+ GRK 
Sbjct: 27  RVTVNGKTVRELGV---KVSSSDRIEVNGVQLESEEPVYFLLYKPRGVISAVKDDKGRKV 83

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + +F     + +Y  GRLD D+ GLL+LTN+G    +L  P     K Y  +++GIP ++
Sbjct: 84  VTDFFTEVEERIYPIGRLDYDTSGLLLLTNDGDFANKLMHPKYEINKTYVAKLKGIPLKE 143

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ L  GV L DG T PA  +L+                K   TS ++IT++EGRNRQV
Sbjct: 144 NLKKLERGVRLEDGKTAPAKVKLLS-------------LDKKKQTSIVQITIHEGRNRQV 190

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   +G   L+L R      +L  L  GE RE+T
Sbjct: 191 RRMFEAIGHEVLKLKREEYAFLNLAGLKTGEKRELT 226


>UniRef50_Q0AX41 Pseudouridine synthase n=1 Tax=Syntrophomonas wolfei subsp. wolfei
           str. Goettingen RepID=Q0AX41_SYNWW
          Length = 239

 Score =  232 bits (592), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 57/216 (26%), Positives = 97/216 (44%), Gaps = 20/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++ T+ + +F    +K         +  E      +L +KP   +    D  GR  
Sbjct: 26  KVKVNDKTITELAFT---LKPGDRVEFAGKIIEQTDKIYLLLHKPAGYISSLADPQGRPR 82

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      V+  GRLD D+EGLL+L+N+G     +T P     K Y   V+G+   D
Sbjct: 83  VIDLLSAVNTRVFPVGRLDYDTEGLLLLSNDGEFSNLMTHPRYLIPKKYEAWVQGLVKPD 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +  L  GV L DG T PA   L+                     S L++ ++EG+ RQ+
Sbjct: 143 TIRQLEQGVALEDGITAPARVRLLSSKKGQ---------------SLLELEIHEGKKRQI 187

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +RM   VG    +L R A+   +L+ +  G++R +T
Sbjct: 188 KRMCLAVGHRVTKLKRTALAFLTLEGVPRGQFRFLT 223


>UniRef50_C8WXC0 Pseudouridine synthase n=3 Tax=Firmicutes RepID=C8WXC0_ALIAD
          Length = 273

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 71/216 (32%), Positives = 106/216 (49%), Gaps = 16/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    + +   +    ++           E +   V++ NKP   L   +D  GR+T
Sbjct: 27  RVSVDGEIVTQLGAKVDPSRQ--RIAVDGVPIELEQPVVLVLNKPVAYLSTVSDPLGRRT 84

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P   + VY  GRLD D+ GLL+ TN+G L  RL  P +   K+Y V V GI  ++
Sbjct: 85  VMQLLPPIRERVYPVGRLDYDTSGLLLFTNDGELTQRLLHPSREIEKVYRVSVRGIVDRE 144

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
              AL  GV L DG T PA  E++ +              +    + + + ++EGRNRQV
Sbjct: 145 TRRALMEGVELEDGVTAPAKVEVLRQAD------------REDGVAVVHLAIHEGRNRQV 192

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   +G P LRL R A G  SL +L  GEWR +T
Sbjct: 193 RRMFERLGLPVLRLKRIAFGPVSLGHLKTGEWRALT 228


>UniRef50_C9KIR7 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KIR7_9FIRM
          Length = 250

 Score =  230 bits (588), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 67/218 (30%), Positives = 104/218 (47%), Gaps = 14/218 (6%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  +    +++   +        +     +K   +     +L NKP   L    D+ GR+
Sbjct: 30  RVRVDGQVVRELGTKVDPA--AHTILVDGKKIAGEEQHVYLLLNKPKGYLSTAKDDRGRR 87

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P   + VY  GRLD ++EGLL++TN+GAL   L  P     K Y+  V G  T+
Sbjct: 88  TVLDLLPEVRERVYPVGRLDNNTEGLLLITNDGALMNGLLHPRFEVEKTYHAGVTGKLTE 147

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+ LR+G+ L DG T PA   L+ E              +    +   IT++EGRNRQ
Sbjct: 148 EKLQMLRDGLLLEDGMTAPAKVSLLPEREPGE---------RVRGLTRAAITIHEGRNRQ 198

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRRM A VG     L R      +L  +A G+ R +T+
Sbjct: 199 VRRMFAAVGCDVKSLKRVRFAGLTLKGVARGQHRALTE 236


>UniRef50_P35159 Ribosomal large subunit pseudouridine synthase B n=200 Tax=Bacteria
           RepID=RLUB_BACSU
          Length = 244

 Score =  230 bits (588), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 102/216 (47%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +      +V           K E +     L  KP  V+    D+ GRK 
Sbjct: 27  KVKVNGKVVTELGV---KVTGSDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKV 83

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + +F     Q +Y  GRLD D+ GLL+LTN+G    +L  P     K Y  +V+GIP ++
Sbjct: 84  VTDFFKNIPQRIYPIGRLDYDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKE 143

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  L  G+ L +G T PA A+L+                K   TS +++T++EGRNRQV
Sbjct: 144 LLRKLERGIRLEEGKTAPAKAKLLS-------------LDKKKQTSIIQLTIHEGRNRQV 190

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   +G   ++L R      +L  L  G+ RE+T
Sbjct: 191 RRMFEAIGHEVIKLKREEYAFLNLRGLHTGDARELT 226


>UniRef50_D1CFA0 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CFA0_THET1
          Length = 253

 Score =  229 bits (586), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 80/217 (36%), Positives = 109/217 (50%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +                R   +    QP  R IL NKP  VL    DE GRK
Sbjct: 30  RVSVNGRIVNTPGAM---ASPEDEIRVDGKLVRQQPKMRYILLNKPAGVLSTAKDERGRK 86

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + +     VY  GRLD+DSEGL++LTN+G L  R+T P     K Y V+VEG  +  
Sbjct: 87  TVIDLLGQSNRVYPVGRLDKDSEGLMLLTNDGELAQRITHPRYGVHKQYMVEVEGYFSDR 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           +L+ L  GV L DG + P  A+++                +S   S L IT+ EGR RQV
Sbjct: 147 SLQDLLQGVELEDGFSKPLDAKIIS---------------RSRDKSKLLITMGEGRKRQV 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR  A +G+   RL R A+G  SL NL  GE+RE++D
Sbjct: 192 RRTLAALGYKVKRLTRVALGPLSLGNLKPGEYRELSD 228


>UniRef50_C7MNA2 Pseudouridine synthase n=1 Tax=Cryptobacterium curtum DSM 15641
           RepID=C7MNA2_CRYCD
          Length = 296

 Score =  229 bits (586), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 58/217 (26%), Positives = 95/217 (43%), Gaps = 21/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +   +                     P   +  NKP  ++    D  GR+
Sbjct: 75  RVAVNGIVITELGTKV--DPLVDEVCVDGAIVTWGAPAVTLALNKPAGIITTMKDLRGRR 132

Query: 62  TLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
            + + +P     G++  GRLD+D+ GLL+ + +G L   L  P     K+Y   +EG   
Sbjct: 133 CVADIMPTEQYPGLFPIGRLDQDTTGLLLFSTDGNLGNALLHPSHGVSKVYRATIEGSIG 192

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           Q ALE L +G+ L+DG T PA   +V               +     S +++ L+EGR  
Sbjct: 193 QAALEQLASGILLDDGMTAPARVSVV---------------QAGKKHSVIELELHEGRKH 237

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           QV+RM   VG P ++L R + G   L  LA G +R +
Sbjct: 238 QVKRMCQAVGHPVVKLHRASFGPIDLAGLATGAYRRL 274


>UniRef50_B8G2X0 Pseudouridine synthase n=3 Tax=Bacteria RepID=B8G2X0_CHLAD
          Length = 567

 Score =  229 bits (586), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 95/217 (43%), Gaps = 19/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +     R              +          I+ +KP  V+    D  GR 
Sbjct: 29  RVTVNGRVVTVPGTRV--DLEHDEVLVDGQPLRMPAKRTYIMLHKPAGVVSTAEDPHGRP 86

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + + V   V+  GRLD DSEGL++LT++G L   LT P     K Y V ++   T D
Sbjct: 87  TVVDLVDVPARVFPVGRLDLDSEGLILLTDDGELAYALTHPSFEVEKEYRVLLDRALTPD 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           AL + RNGV L    T PA  EL++                +    W++I L EGR RQ+
Sbjct: 147 ALRSWRNGVLLEGEMTAPAWVELLE---------------TTPEGVWVRIVLREGRKRQI 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R +   +G+   RL+R   G   L +L    WR +TD
Sbjct: 192 RAVAKLLGYEVRRLVRVREGPLQLGDLPPRAWRHLTD 228


>UniRef50_Q87QY8 Ribosomal large subunit pseudouridine synthase E n=244 Tax=Bacteria
           RepID=RLUE_VIBPA
          Length = 238

 Score =  229 bits (585), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 115/183 (62%), Positives = 145/183 (79%), Gaps = 1/183 (0%)

Query: 33  KPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNG 92
           + + Q  +VI+FNKPYD L QFTD  GRKTL ++IPV+ VYAAGRLDRDSEGL+VLTN+G
Sbjct: 55  RVDLQNRKVIIFNKPYDTLSQFTDGDGRKTLADYIPVKDVYAAGRLDRDSEGLMVLTNDG 114

Query: 93  ALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWP 152
            LQA+LTQP  ++ K Y+VQV+G P +  LE LR GV L DG TLPA  E++D P  +W 
Sbjct: 115 ILQAKLTQPKSKSPKTYWVQVDGAPQEQDLEKLRKGVELKDGMTLPAKVEVIDAPT-IWE 173

Query: 153 RNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           RNPP+R R +IPT+WL IT+ EGRNRQVRRMTAH+GFPTLRL+RY+MGD +L +L  G+W
Sbjct: 174 RNPPVRFRANIPTTWLAITIIEGRNRQVRRMTAHIGFPTLRLVRYSMGDITLGDLQPGQW 233

Query: 213 REV 215
           +E+
Sbjct: 234 KEI 236


>UniRef50_Q24V73 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q24V73_DESHY
          Length = 257

 Score =  228 bits (583), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 72/219 (32%), Positives = 96/219 (43%), Gaps = 21/219 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK--PENQPTRVILFNKPYDVLPQFTDEAGR 60
           +  ++   ++       +V          R            L +KP   +   TD  GR
Sbjct: 41  RVKVNGEVIR---TLGTKVVSTDRIVVDGRLLSIPQNDYAYYLLHKPTGYITSVTDPQGR 97

Query: 61  KTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           KT+ E +P   + VY  GRLD D+ GLL+LTN+G L  RL  P     K Y V+V     
Sbjct: 98  KTVMELMPKIPRRVYPVGRLDYDTSGLLLLTNDGDLAHRLMHPSYGVEKTYRVEVGEKIP 157

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           + AL+ L  GV L DG T PA    V                        +IT++EGRNR
Sbjct: 158 EQALKRLEKGVLLEDGKTAPARIREVSPKG-------------RGSLPTYEITIHEGRNR 204

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QVRRM   VGFP   L R   G   LD +LA G +R ++
Sbjct: 205 QVRRMFKAVGFPLSTLKRLRFGPLELDPSLAPGAFRTLS 243


>UniRef50_D1Y0J0 Pseudouridine synthase n=1 Tax=Prevotella bivia JCVIHMP010
           RepID=D1Y0J0_9BACT
          Length = 555

 Score =  228 bits (583), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 51/218 (23%), Positives = 98/218 (44%), Gaps = 22/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + +      ++ R    +   +    +    +L NKP D +    D   RKT
Sbjct: 345 QVTVNGEVINEL---GTKILRTDEVKFQDKLVSLEKKVYVLLNKPKDYVTTSDDPQQRKT 401

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +     + +Y  GRLDR++ G+L+ TN+G L ++LT P     K+Y+V ++   T 
Sbjct: 402 VMDLVKDACPERIYPVGRLDRNTTGVLLFTNDGDLASKLTHPKFLKKKVYHVFLDKPITA 461

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+ + +G+ L DG       E  +                      + I ++ G+NR 
Sbjct: 462 NELQKISDGIELEDGEIKADAIEYANPEDQA----------------QVGIEIHSGKNRI 505

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRR+   +G+  ++L R      +  N+  G+WR +T+
Sbjct: 506 VRRIFESLGYRVVKLDRVMFAGLTKKNVRRGDWRFLTE 543


>UniRef50_B2RK43 Pseudouridine synthase n=1 Tax=Porphyromonas gingivalis ATCC 33277
           RepID=B2RK43_PORG3
          Length = 439

 Score =  228 bits (582), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 22/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +      ++ R        ++ E +    +L NKP + +    D   R T
Sbjct: 229 EITVNGEVVTEL---GRRITRQDEVIYKDKRVEIESKVYVLLNKPKNCVTTSDDPECRTT 285

Query: 63  LKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +     + +Y  GRLDR++ G+L++TN+G L ++LT P  +  KIY+V +    + 
Sbjct: 286 VMDIVRYACPERIYPVGRLDRNTTGVLLITNDGDLASKLTHPSFKKKKIYHVWLNKDVSI 345

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + ++ + +GV L+DG         V E                   S + I ++ GRNR 
Sbjct: 346 EDMQKIADGVELDDGEIHADAISYVKED----------------DLSQVGIEIHSGRNRI 389

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           VRR+  H+G+  ++L R      +  NL  G+WR + +
Sbjct: 390 VRRLFEHLGYRVVKLDRVYFAGLTKKNLPRGKWRYLNE 427


>UniRef50_C0FY58 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C0FY58_9FIRM
          Length = 261

 Score =  228 bits (581), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 62/221 (28%), Positives = 98/221 (44%), Gaps = 24/221 (10%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q  ++   + K   +                         LF KP   +    D    K
Sbjct: 49  KQITVNGEIVTKPETKV--APENDQISYKGEPVTYCEYEYYLFYKPAGCVTATED-QLHK 105

Query: 62  TLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ +++       ++  GRLD D+EGLL++TN+GAL   L  P K   K YY  ++G+ T
Sbjct: 106 TVMDYLTDTVRSDLFPVGRLDIDTEGLLLITNDGALAHDLLSPAKHVEKTYYAVIDGVVT 165

Query: 119 QDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           +  + +  NGV +  +  T P    ++                KS P S +++T+ EGR 
Sbjct: 166 EKDVNSFENGVDIGEEKLTKPGKLRIL----------------KSEPESEIELTITEGRF 209

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
            QV+RM   VG   L L R +MG   L D+L  GE+R +T+
Sbjct: 210 HQVKRMFEAVGKKVLYLKRISMGPLQLTDDLKPGEYRPLTE 250


>UniRef50_A9GX03 Pseudouridine synthase n=2 Tax=Bacteria RepID=A9GX03_SORC5
          Length = 399

 Score =  226 bits (578), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 102/216 (47%), Gaps = 19/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   +  + K         ++  ++    +  +KP +V+    D  GR T
Sbjct: 28  RVRVNGRVVTELGLKADRQK--DRIEVDGKRLVSEAPVYVALHKPRNVVSTLRDPEGRPT 85

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      +Y  GRLD  + G+L++TN+G     L  P     K Y ++V+G+ + D
Sbjct: 86  VADHVRGTGARLYPVGRLDFATSGILLMTNDGDFANALLHPRGGVPKTYVLKVQGVMSDD 145

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L   R G+ L DG TLPA A L+               R     +WL++TL EGRN+Q+
Sbjct: 146 DLTPWREGIRLEDGVTLPAEARLL---------------RHEGDKTWLEVTLREGRNQQI 190

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM    G+P +RL R      S + L  GEWR +T
Sbjct: 191 RRMGEATGWPVMRLARTTFAGVSSEGLRPGEWRALT 226


>UniRef50_D2QMI8 RNA-binding S4 domain protein n=16 Tax=Bacteroidetes
           RepID=D2QMI8_9SPHI
          Length = 638

 Score =  226 bits (577), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 98/215 (45%), Gaps = 23/215 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +     ++VK   + +   +    +    +L NKP D +    D   RKT+
Sbjct: 431 ISVNGKIVTE---MGYKVKEGDTVKYGTKVLNPERFVYVLLNKPKDYITTTEDPEERKTV 487

Query: 64  KEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            E +       +Y  GRLDR++ GLL++TN+G L  +LT P     KIY V+++   T +
Sbjct: 488 MELVADAGKFRMYPVGRLDRNTTGLLLITNDGELADKLTHPSNNIRKIYQVELDKPITDE 547

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             EA++ G+ L DGP  P    +V   A++                 + I ++ GRNR V
Sbjct: 548 HFEAIKKGIELEDGPIKPDAISIVTPDAYV-----------------VGIEIHSGRNRIV 590

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RR+    G+   +L R      +   L  G+WR +
Sbjct: 591 RRIFESFGYEVTKLDRTTYAGLTKKELPRGKWRFL 625


>UniRef50_C2D7I2 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7I2_9ACTN
          Length = 285

 Score =  226 bits (576), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 55/223 (24%), Positives = 95/223 (42%), Gaps = 11/223 (4%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   ++    +     ++       ++         +L NKP  VL   +D  G  
Sbjct: 50  RVCVNGKQVRVLGTKVMP--QYDHVTVDGKEYVLGNDHVYLLLNKPSQVLTTMSDPFGFP 107

Query: 62  TLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
            +   +P     G++  GRLD D+ G+L+ T NG +  RL  P     K Y   +EG  T
Sbjct: 108 CVASLVPCDDYPGLFPVGRLDSDTTGVLLFTTNGNMGNRLLHPSHHVWKTYVALIEGKLT 167

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE----RKSIPTSWLKITLYE 174
              ++ L  G+ L DG T P     + +       +         R +  +S  ++ ++E
Sbjct: 168 SSQMQKLSQGIMLEDGMTSPCFIRTITQDEPCTHLDKNHSLFDDMRLNAASSLCELKIHE 227

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
           GRN QV+RM   +G P ++L R+  G   L+  +  G WR  T
Sbjct: 228 GRNHQVKRMLQEIGHPVIKLHRFQFGPLCLNAQIPLGSWRMCT 270


>UniRef50_C6Y027 Pseudouridine synthase n=1 Tax=Pedobacter heparinus DSM 2366
           RepID=C6Y027_PEDHD
          Length = 472

 Score =  225 bits (575), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 54/217 (24%), Positives = 97/217 (44%), Gaps = 21/217 (9%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +   +   VK     R      + +    +L NKP D +    D   R+T+
Sbjct: 263 VSVNGEVVSELGHKIDPVK--DQVRYNGELLKREKKIYVLLNKPKDYITTTDDPQERRTV 320

Query: 64  KEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +     + +Y  GRLDR++ GLL++TN+G L  +L+ P     KIY+V++    +Q 
Sbjct: 321 MQLVEKASRERIYPVGRLDRNTTGLLLMTNDGDLADKLSHPKNGITKIYHVELSRSLSQG 380

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  ++ G+ L DG   P     V                       + I ++ G+NR V
Sbjct: 381 DLNKIQFGLELEDGIIKPDSVSYVT----------------GGSKREVGIQIHSGKNRIV 424

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+  H+G+  ++L R   G+ +  +L  G WR + +
Sbjct: 425 RRIFEHLGYDVVKLDRVVYGNLTKKDLPRGRWRYLEE 461


>UniRef50_B0N6F1 Pseudouridine synthase n=3 Tax=Bacteria RepID=B0N6F1_9FIRM
          Length = 241

 Score =  225 bits (574), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 96/215 (44%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +      +VK+        +    +     +F KP   +    DE  R  
Sbjct: 27  KVEVNGKVVTEL---GTKVKQGDLITVEGKPLVGENKVYYVFYKPKGCVCTLDDEFDRPI 83

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + ++     + +Y  GRLD D+ GL++++N+G     +  P     KIY V ++G+ T  
Sbjct: 84  ITDYFTEVKERIYPVGRLDFDTTGLIIMSNDGEFANMIMHPRSHLEKIYEVSIKGLITGP 143

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  L  GV L    TLP   ++VD+                  T+ LKI L EG+NRQV
Sbjct: 144 TLNKLEKGVYLEGVKTLPCKIKVVDKDT-------------EHKTTMLKIKLVEGKNRQV 190

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ++M   VG P  RL R ++G  +L  L  G +R +
Sbjct: 191 KKMFESVGHPVKRLHRVSIGGINLKGLTPGRYRIL 225


>UniRef50_C7M7R0 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C7M7R0_CAPOD
          Length = 387

 Score =  225 bits (574), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 22/216 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   M       ++VK     R   +   ++    IL NKP   +    DE GRKT+
Sbjct: 180 VTVNGEVMT---TLGYRVKPTDEVRFDGKLLSSEKKEYILLNKPKGFITTTNDEKGRKTV 236

Query: 64  KEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +       +   GRLDR + GLL+LTN+G L  +LT P     KIY+V ++      
Sbjct: 237 MDLVANATNVRILPVGRLDRATTGLLLLTNDGELTKKLTHPTHGVRKIYHVILDRKLDYK 296

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
               +++G+ L DG         V++                 P + + I ++ GRNR V
Sbjct: 297 DFMKVQDGLELEDGLIEVDEISYVND----------------KPKNEIGIKIHSGRNRIV 340

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RR+  H+G+   +L R      +  +L  G WR +T
Sbjct: 341 RRIFEHLGYQVEKLDRVVFAGLTKKDLPRGHWRRLT 376


>UniRef50_UPI000196BAD7 hypothetical protein CATMIT_00510 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196BAD7
          Length = 247

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +        +V +  +     +    +     LF KP   +   +DE  R  
Sbjct: 28  KVTVNGEVVT---VLGTKVTKKDTICVNGKLINKEDKVYYLFYKPEKCVCTMSDEHDRTC 84

Query: 63  LKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + ++     + VY  GRLD D+ G L +TN+G     +  P     K+Y V V+G+ T+ 
Sbjct: 85  VADYFADSNERVYPVGRLDYDTTGALFMTNDGEFANLIMHPSSHLEKVYEVSVKGLLTKA 144

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
               L  G+ L    TLP    +                 +   T+ L I L EG+NRQ+
Sbjct: 145 EKNQLEKGIYLEGVKTLPCEIAITGND-------------EEHGTTMLLIRLVEGKNRQI 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ++M   VG P  RL R  +G   L  L  G +R +
Sbjct: 192 KKMFEEVGHPVKRLRRIMIGPIDLKGLTPGTYRRL 226


>UniRef50_C3JBA6 Pseudouridine synthase n=2 Tax=Bacteria RepID=C3JBA6_9PORP
          Length = 459

 Score =  223 bits (570), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 54/217 (24%), Positives = 94/217 (43%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +       V R        +    +    +L NKP + +   +D   R T 
Sbjct: 250 VSVNGEIVTQL---GKHVTREDFISVDGKPVSIEKKIYVLLNKPRNCVTTSSDPEKRLTA 306

Query: 64  KEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +     + +Y  GRLDR++ GLL+LTN+G L A+L  P     KIY V ++   + +
Sbjct: 307 IDLVRNACNERIYPVGRLDRNTTGLLLLTNDGDLAAKLMHPKYEKKKIYQVTLDKPVSVE 366

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            ++ + +G+ L DG         VDE                   + + I ++ GRNR V
Sbjct: 367 HMQQIASGIELEDGEIHADAISYVDEN----------------NLAIVGIEIHSGRNRIV 410

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+  H+G+   +L R      +  +L  G WR +T+
Sbjct: 411 RRIFKHLGYRVYKLDRVYFAGLTKKDLPRGRWRYLTE 447


>UniRef50_P72581 Uncharacterized RNA pseudouridine synthase slr0612 n=16
           Tax=Bacteria RepID=Y612_SYNY3
          Length = 261

 Score =  223 bits (570), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 103/205 (50%), Positives = 127/205 (61%), Gaps = 20/205 (9%)

Query: 31  RRKPENQPTRVILFNKPYDVLPQFTDE--AGRKTLKEFIPVQGVYAAGRLDRDSEGLLVL 88
                N+  + I+F KPY VL QFTD     R TLK++I +  +Y  GRLD+DSEGLL+L
Sbjct: 31  GLIALNKTPQTIVFYKPYGVLCQFTDNSAHPRPTLKDYINLPDLYPVGRLDQDSEGLLLL 90

Query: 89  TNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPA 148
           T+NG LQ RL        + Y+ QVEG PT + LE LR G+T  D PT PA A+++ EP 
Sbjct: 91  TSNGKLQHRLAHREFAHQRTYFAQVEGSPTDEDLEPLRRGITFADYPTRPAIAKIITEPD 150

Query: 149 WLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM---GD---- 201
              PRNPPIR R SIPTSWL ITL EGRNRQVRRMTA VGFPTLRL+R  +   G     
Sbjct: 151 -FPPRNPPIRYRASIPTSWLSITLTEGRNRQVRRMTAAVGFPTLRLVRVQIQVTGRSPQQ 209

Query: 202 ----------YSLDNLANGEWREVT 216
                      +L+ L+ G+WR +T
Sbjct: 210 GKGKSAATWCLTLEGLSPGQWRPLT 234


>UniRef50_O67444 Uncharacterized RNA pseudouridine synthase aq_1464 n=4 Tax=Bacteria
           RepID=Y1464_AQUAE
          Length = 249

 Score =  223 bits (569), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQF-TDEAGRK 61
           +  ++   ++    + +            +  + Q  R I+ NKP   L Q      GRK
Sbjct: 29  RVKVNGEVVRSLGVKVNP--EVDIVEVDGKPVKPQRKRYIILNKPCCYLTQLGRSPDGRK 86

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T++E I    + V+  GRLD ++EGLL+LTN+G L  R+  P  +  K+Y   VEG   Q
Sbjct: 87  TIEELIKDIPERVFPVGRLDYNTEGLLILTNDGELANRILHPRYKLPKVYLALVEGKVDQ 146

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ ++ G+ L DG   P    +V               R     + L+IT +EGR   
Sbjct: 147 KTLKRMKQGIELEDGFAKPDNIRIV---------------RYEGKNTLLEITFHEGRKHL 191

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           V+R     G    RL R A+G   L  L+ G+WRE+ 
Sbjct: 192 VKRFLGAFGHKVKRLKRIAIGPIKLGKLSPGKWRELN 228


>UniRef50_A3ZQL4 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZQL4_9PLAN
          Length = 517

 Score =  223 bits (569), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 64/214 (29%), Positives = 100/214 (46%), Gaps = 18/214 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    + +   +              ++ +       + NKP  VL    D AGR  
Sbjct: 42  RVEVDGKFVTELGMKV--DPEHQEILVDGQRLKFGKRVYYMLNKPPGVLSTNFDPAGRTR 99

Query: 63  LKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +P    ++  GRLDR SEGL+V+TN+G L  RL  P     K Y V+V G P  DA
Sbjct: 100 VIDMVPQDVRLFTIGRLDRASEGLIVVTNDGELANRLAHPRYEIEKTYRVEVAGHPEPDA 159

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +  +R GV L +G   P                  + +RK+  ++ L++ L EG+NR++R
Sbjct: 160 ITFVRRGVHLAEGFVQPVSV---------------VMKRKNKQSTTLEVILDEGKNREIR 204

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R+ A +G   LRL R AMG   L  +  G +RE+
Sbjct: 205 RLMAKIGHKVLRLKRIAMGPLRLGEMPEGAFREL 238


>UniRef50_A4BDP6 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BDP6_9GAMM
          Length = 228

 Score =  223 bits (568), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 105/176 (59%), Positives = 133/176 (75%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           R +LFNKP+ VL QFTD   R+TL +FI V  VY+AGRLD DSEGLL+LT++GAL   + 
Sbjct: 3   RYLLFNKPFQVLTQFTDPDNRQTLADFIDVPEVYSAGRLDYDSEGLLLLTDDGALIHSMM 62

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +T K Y  QVEG  T +A+  L +G+ L DGPTLPA A  V EPAWLWPR PPIRE
Sbjct: 63  NPRFKTPKTYLAQVEGDITDEAIRRLESGLQLKDGPTLPAKARRVSEPAWLWPRQPPIRE 122

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R +IP SW+++TL EGRNRQVRRMTA VGFPTLRLIR A+ + ++++L+ G+++EV
Sbjct: 123 RATIPASWVELTLVEGRNRQVRRMTAAVGFPTLRLIRVALAELTVESLSVGQYKEV 178


>UniRef50_B4U4Q4 Pseudouridine synthase n=15 Tax=Lactobacillales RepID=B4U4Q4_STREM
          Length = 266

 Score =  222 bits (567), Expect = 6e-57,   Method: Composition-based stats.
 Identities = 57/215 (26%), Positives = 99/215 (46%), Gaps = 18/215 (8%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   +   +     VK             N+     L NKP  V+   +D+ GR+T+
Sbjct: 53  VTLNGQVVTDLATT---VKSGDLVEIEGSPIYNEEKVYYLLNKPRGVISSVSDDKGRQTV 109

Query: 64  KEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            + +P   + +Y  GRLD D+ GLL+LTN+G    ++  P     K+Y  +V+G+ T+++
Sbjct: 110 IDLLPQVKERIYPVGRLDWDTSGLLILTNDGDFTDKMIHPRNEIDKVYLARVKGVVTKES 169

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L  L  GV ++   T PA   ++             R       S +++T++EGR+ QV+
Sbjct: 170 LRPLTRGVVIDGKKTKPARYRII-------------RVEPDKNRSIVELTIHEGRHHQVK 216

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           +M   VG    +L R   G   +  L  GE R ++
Sbjct: 217 KMFEAVGHLVDKLSRTQFGSLDVRGLKPGEARRLS 251


>UniRef50_B2A4P2 Pseudouridine synthase n=2 Tax=Clostridia RepID=B2A4P2_NATTJ
          Length = 238

 Score =  221 bits (565), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +   + +      + +        + +   I+ NKP D +    D  GRK
Sbjct: 26  RVTVNGQVITRLGTKINP--DTDTVKVDGEPITQEESNVYIMLNKPKDYITSKDDPQGRK 83

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + I   + VY  GRLD DS GL++LTN+G L  RL  P     K Y V+V+ +P QD
Sbjct: 84  TVMDLIQVKERVYPVGRLDYDSRGLVLLTNDGELANRLMHPKYNIPKTYMVKVDKLPLQD 143

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ L NG+ L +G       E++D                    + LKI L EGR RQ+
Sbjct: 144 KLDNLVNGIYLEEGLCKADHVEILDT-----------------KNNILKIILSEGRKRQI 186

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM A +G     L R ++G  +L +L+ G +R++T
Sbjct: 187 RRMLASLGIEVKDLKRDSLGTLTLKDLSEGNYRKLT 222


>UniRef50_A4CJ52 Pseudouridine synthase n=5 Tax=cellular organisms
           RepID=A4CJ52_9FLAO
          Length = 303

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 60/217 (27%), Positives = 100/217 (46%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++  T+ +     ++V+     R   R  + +    +L NKP + +    DE GR+T+
Sbjct: 96  VTVNGKTITE---MGYKVQPTDEVRFDGRLLQRERKEYVLLNKPRNFITTTRDEKGRRTV 152

Query: 64  KEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            E I       +   GRLDR++ GLL+ TN+G L  +LT P     KIY+V+++      
Sbjct: 153 MELISRASNARLVPVGRLDRNTTGLLLFTNDGELAKKLTHPKHGVRKIYHVELDKTFKSA 212

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  LR G+ L DG      A  +D  +                   + + L+ GRNR V
Sbjct: 213 DLGKLREGLELEDGRIEVDEASYIDGASKKE----------------VGVELHSGRNRIV 256

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+  H+G+  ++L R  +   +  +L  G WR +T+
Sbjct: 257 RRIFEHLGYQVVKLDRVVLAGLTKKDLPRGHWRHLTE 293


>UniRef50_A4J9G8 Pseudouridine synthase n=47 Tax=Bacteria RepID=A4J9G8_DESRM
          Length = 249

 Score =  220 bits (562), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 70/222 (31%), Positives = 107/222 (48%), Gaps = 25/222 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q +++              +            E +    ++ NKP DVL    D +  K
Sbjct: 31  KQVMVNGELAMDPGLHIFPQR--DHIEVQGEVIEYREYIYLMLNKPQDVLSATEDASD-K 87

Query: 62  TLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            + + +         +  GRLD+D+EGLL+LTNNG L  +L  P K   K YY  V+G+ 
Sbjct: 88  VVIDLLDPTYHSFNPFPVGRLDKDTEGLLLLTNNGKLAHQLLSPKKHVPKTYYALVQGLV 147

Query: 118 TQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           T++ + A   GV L+DG  TLP   +++                +S P S +++T+YEG+
Sbjct: 148 TEEDVAAFARGVELDDGYRTLPGQLKII----------------RSAPQSEIELTIYEGK 191

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
             QV+RM   VG   + L R +MG   LD NL  GE+RE+TD
Sbjct: 192 YHQVKRMFEAVGKRVIYLKRLSMGPLVLDNNLKPGEYRELTD 233


>UniRef50_A6LIA0 Pseudouridine synthase n=23 Tax=Bacteroidales RepID=A6LIA0_PARD8
          Length = 495

 Score =  220 bits (562), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 52/217 (23%), Positives = 96/217 (44%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             +++  + +      ++ R        +  + +    I+ NKP + +    D   R T+
Sbjct: 286 VKVNDVVVTEL---GTKITRQDVVTFNEKPVQIESKVYIVLNKPKNCVTTSDDPQERLTV 342

Query: 64  KEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +     + +Y  GRLDR++ G+L+LTN+G L ++LT P  +  KIY+V ++     +
Sbjct: 343 MDLVKNACQERIYPVGRLDRNTTGVLLLTNDGDLASKLTHPSFKKKKIYHVWLDKNVAIE 402

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +E + NG+ L DG           E                   S + I ++ GRNR V
Sbjct: 403 DMEKIANGLELEDGEIHADAISYASED----------------DKSQVGIEIHSGRNRIV 446

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+   +G+   +L R      +  NL  G+WR + +
Sbjct: 447 RRIFESLGYHVTKLDRVYFAGLTKKNLGRGKWRYLNE 483


>UniRef50_D0IWI1 Pseudouridine synthase n=2 Tax=Comamonas testosteroni
           RepID=D0IWI1_COMTE
          Length = 223

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 103/185 (55%), Positives = 132/185 (71%)

Query: 28  RSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLV 87
              +  P    TR++ F+KPY VL QFT E   + LK++I V GVY AGRLD DSEGLL+
Sbjct: 30  VVRQPAPRPGVTRLLCFHKPYGVLSQFTPEGKWQGLKDWIDVPGVYVAGRLDADSEGLLL 89

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEP 147
           LTN+G LQAR+  P  +  K Y+VQVEGIP + AL+ LR GV L+DG TLPA A L++  
Sbjct: 90  LTNDGQLQARIADPRHKMEKTYWVQVEGIPDEAALQRLREGVELSDGKTLPAKARLIEPQ 149

Query: 148 AWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNL 207
             +WPRNPPIR R++IP  W+++ + EGRNRQVRRMTA VG PTLRL+R A+G YS++ L
Sbjct: 150 PLMWPRNPPIRVRQNIPDCWIELIIREGRNRQVRRMTAAVGHPTLRLVRMAVGPYSIEGL 209

Query: 208 ANGEW 212
             G+W
Sbjct: 210 EPGQW 214


>UniRef50_C6MZI4 Pseudouridine synthase n=1 Tax=Legionella drancourtii LLAP12
           RepID=C6MZI4_9GAMM
          Length = 240

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 102/173 (58%), Positives = 126/173 (72%), Gaps = 1/173 (0%)

Query: 41  VILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
           +ILFNKP+ V+ QFT E    TL EFI     YAAGRLD++SEGLL+LTN+GALQ +LT 
Sbjct: 55  LILFNKPFAVVCQFTGEKHEHTLAEFIDKPDFYAAGRLDKNSEGLLLLTNDGALQHQLTH 114

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P     K Y+VQVEGIPT   LE L+ G+ L D   LPA    ++EPA LWPR PP+R R
Sbjct: 115 PKFNKKKYYWVQVEGIPTAADLEPLKKGLVLKDITFLPAEVRCIEEPA-LWPRTPPVRFR 173

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
           +SIPTSWL+I L EG+N QVRRMTA +GFPTLRL+R+ +GD+ L +L  GE+R
Sbjct: 174 QSIPTSWLEIILREGKNHQVRRMTAAMGFPTLRLVRHRIGDWQLGDLQPGEFR 226


>UniRef50_B5YJH7 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YJH7_THEYD
          Length = 237

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 68/218 (31%), Positives = 104/218 (47%), Gaps = 23/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRF-SSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGR 60
           +  ++       +    +        +   +   + +P     F KP  V+    D  GR
Sbjct: 28  RVTVNGQI----AVIGQKADPEKDYIKVDGKLLIKPEPKVYYAFYKPRKVITALLDPQGR 83

Query: 61  KTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
            T+++FI      +Y  GRLD DSEGLL+LTN+G L  ++  P  +  K Y V+V+GI  
Sbjct: 84  PTIRDFIKGIKFRIYPVGRLDFDSEGLLLLTNDGELAYKVMHPSSQIEKTYMVKVDGIVE 143

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            + +E LR G+ +     +P    LV               +K    SW+KITL+EGR R
Sbjct: 144 PETIEKLRKGIKIEGKLAVPVSVHLV---------------KKLKANSWIKITLHEGRKR 188

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           Q+R+M   VG P +RLIR A+    L +L  G+ R +T
Sbjct: 189 QIRKMLERVGHPVIRLIRIAIDGVKLGDLKPGQLRPLT 226


>UniRef50_C2MA52 Pseudouridine synthase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MA52_9PORP
          Length = 472

 Score =  219 bits (560), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 22/217 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +   S    QV          +    +    +L NKP + +   TD  GR+T
Sbjct: 231 RVKVNGAVV---SELGSQVLPTDQVMVDDKPVTLEAKVYVLLNKPKNCVTTLTDPEGRRT 287

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +     + +Y  GRLDR++ G+L+LTN+G L  RL  P  R  KIY V ++   T 
Sbjct: 288 VMDLVHNACTERIYPIGRLDRNTTGILLLTNDGDLAVRLMHPAFRKKKIYEVALDKEVTV 347

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + ++ + +G  L DG         +                       + I ++ GRNR 
Sbjct: 348 EHMQMIAHGFELEDGEIHADAISYIT----------------GQTHDKVGIEIHSGRNRI 391

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRR+  H+G+  + L R      +  +L  G WR +T
Sbjct: 392 VRRIFEHLGYRVVHLDRVYYAGLTKKDLPRGRWRYLT 428


>UniRef50_A3CPQ5 Pseudouridine synthase n=3 Tax=Firmicutes RepID=A3CPQ5_STRSV
          Length = 242

 Score =  219 bits (558), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 103/216 (47%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  I+   +++ +     VK         +   N+     L NKP  V+   +D+ GRKT
Sbjct: 26  KVSINGQVVRELATN---VKSGDRVEVEGQPIYNEEKVYYLLNKPRGVISSVSDDKGRKT 82

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + E +P   + +Y  GRLD D+ G+L+LTN+G     +  P     K+Y  +V+G+  ++
Sbjct: 83  VVELLPQVKERIYPVGRLDWDTSGILILTNDGDFTDEMIHPRNEIDKVYVARVKGLANKE 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L  L  G+ +    T PA  E++             +   +   S +++T++EGRN QV
Sbjct: 143 VLRPLTRGIEIEGRKTKPAVYEII-------------KVDPAKNRSVVQLTIHEGRNHQV 189

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++M   VG    +L R   G   L  L  GE+R+++
Sbjct: 190 KKMFQAVGLQVDKLSRTRFGHLDLTGLKPGEYRKLS 225


>UniRef50_C1F236 Pseudouridine synthase n=8 Tax=Bacteria RepID=C1F236_ACIC5
          Length = 406

 Score =  219 bits (558), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 63/220 (28%), Positives = 104/220 (47%), Gaps = 18/220 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +  F+          R   +  +  +  R  + NKP   +   +D  GR 
Sbjct: 49  RVQVNGQVVTEMGFKADAAS--DHIRVDGKLLQGPEKLRYFMLNKPKGYVTTVSDPEGRH 106

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ EF        + +Y  GRLD  SEGLL++TN+GAL   LT+      K+Y V+V G 
Sbjct: 107 TVMEFFHGRGKGGERLYPVGRLDYASEGLLLMTNDGALANTLTKASSHVEKVYLVKVSGR 166

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           PT++ LE +R G+ ++ G   P    ++  PA        +R  +     W ++TL EGR
Sbjct: 167 PTEEQLEQIRAGIMIDRG--RPGEGRVMTAPAG-------VRMVRDAENPWFELTLIEGR 217

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           NR++R+M    G    ++ R   G   L ++  GE RE+ 
Sbjct: 218 NREIRKMFEETGHFVEKIRRIGYGPLVL-DVEPGEVRELN 256


>UniRef50_A4SY81 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A4SY81_POLSQ
          Length = 587

 Score =  218 bits (557), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 65/225 (28%), Positives = 97/225 (43%), Gaps = 25/225 (11%)

Query: 1   MRQFIISENTMQK--TSFRNHQVKRFSSQRSTR----RKPENQPTRVILFNKPYDVLPQF 54
           M   II          +    ++      R       RK + +P RVI+++KP   +   
Sbjct: 214 MEDLIIQGRVSVNGLPAHIGQRIGPTDQVRINGKPVHRKIQTKPPRVIMYHKPAGEIVSQ 273

Query: 55  TDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
           +D  GR T+ + +P        A GRLD ++EGLL+ T +G L  RL  P     + Y V
Sbjct: 274 SDPEGRPTVFDRLPKPRQGRWIAVGRLDFNTEGLLLFTTSGELANRLMHPRYGVEREYAV 333

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           ++ G  +Q+    L++G+TL+DG        +                       W  + 
Sbjct: 334 RILGDLSQENTALLKSGITLDDGQAKFLRLAM---------------GGGEGANRWYHVA 378

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           L EGRNR+VRRM   VG    RLIR   G + L   L  G+W E+
Sbjct: 379 LSEGRNREVRRMFEAVGHTVSRLIRTRYGIFLLPPRLRRGKWEEI 423


>UniRef50_P0AA45 Ribosomal small subunit pseudouridine synthase A n=156
           Tax=Gammaproteobacteria RepID=RSUA_ECO57
          Length = 231

 Score =  218 bits (557), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 58/222 (26%), Positives = 96/222 (43%), Gaps = 30/222 (13%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  +    ++  +F   ++               Q   R  + NKP   +    D     
Sbjct: 26  RVTVDGEIVRNAAF---KLLPEHDVAYDGNPLAQQHGPRYFMLNKPQGYVCSTDDP-DHP 81

Query: 62  TLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+  F+       ++AAGRLD D+ GL+++T++G    R+T P     K Y V +E    
Sbjct: 82  TVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESPVA 141

Query: 119 QDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            D  E    GV L++    T PA  E++                     + +++T+ EGR
Sbjct: 142 DDTAEQFAKGVQLHNEKDLTKPAVLEVITP-------------------TQVRLTISEGR 182

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
             QV+RM A VG   + L R  +G  +LD +LA GE+R +T+
Sbjct: 183 YHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTE 224


>UniRef50_D1C7P2 Pseudouridine synthase n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C7P2_SPHTD
          Length = 337

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 66/215 (30%), Positives = 104/215 (48%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +++   R          R   ++   +  R I+ NKP   +   +DE GR+T
Sbjct: 27  RVTVDGQVVRELGVRV--DPERQEIRVDGKRLRPERRRYIMLNKPPGYITTVSDERGRRT 84

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +   + V  AGRLDR + GLL+LTN+G L  R+T P     K Y V V+G P  + 
Sbjct: 85  VMDLVQVPERVVPAGRLDRPTAGLLLLTNDGDLLFRITHPRYELEKEYEVLVDGHPPPEV 144

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L+ LR GVT++    +P     +               R     + L+I ++EGRNR VR
Sbjct: 145 LDQLRRGVTVDGERVVPDQVRPL---------------RIEEAGTVLRIVIHEGRNRIVR 189

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RM   VG+P L+L R  +G   +  +  G WR++T
Sbjct: 190 RMMDRVGYPVLKLTRTRIGPIHVRGVPLGAWRDLT 224


>UniRef50_Q11YT0 Pseudouridine synthase n=9 Tax=Bacteroidetes RepID=Q11YT0_CYTH3
          Length = 562

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 58/217 (26%), Positives = 102/217 (47%), Gaps = 24/217 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +     ++VK   S +   +    + +  +L NKP D +    DE  RKT+
Sbjct: 355 VKVNGIVVTEL---GYKVKPGDSVKYNNKVLNPEKSVYVLLNKPKDFITTMEDENDRKTV 411

Query: 64  KEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +     + +Y  GRLDR++ GLL+ TN+G L  +LT P  +  KIY V+++   T +
Sbjct: 412 MQLVANATKERIYPVGRLDRNTTGLLLFTNDGELAQKLTHPSNKVKKIYEVELDKPITAE 471

Query: 121 ALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             + + +G + L DGP     A ++     +                 + I ++EGRNR 
Sbjct: 472 DFDKIVDGKIHLFDGPVKVDEAAIISPSKKI-----------------IGIEIHEGRNRI 514

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRR+   +G+  L+L R      +  N+  G WR +T
Sbjct: 515 VRRIFESLGYDVLKLDRVMYAGLTKKNIPRGSWRYLT 551


>UniRef50_Q1IJT7 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IJT7_ACIBL
          Length = 680

 Score =  218 bits (555), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 61/224 (27%), Positives = 99/224 (44%), Gaps = 13/224 (5%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++     +   +          R   +  + +    +L +KP   +   +D  GR+T
Sbjct: 29  RVTVNGEVKNELGSK--ADPETDDIRVDGKPLKAEQLVYVLLHKPKGYVTTVSDPEGRET 86

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      +Y  GRLD  SEGLL+LTN+G + A+LT       K Y V+V G PT++
Sbjct: 87  VMDLVKGIPARLYPVGRLDYLSEGLLLLTNDGEMAAKLTHASTHVPKKYLVKVSGEPTEE 146

Query: 121 ALEALRNGVTL--NDGPTLPAGAE------LVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
            ++ LRNGV L    G       E             +      I   +     W ++TL
Sbjct: 147 QIQELRNGVQLPPEQGHIHADPREGGRFGGEKRRSTAVKTAPCKIELTREGDNPWYEVTL 206

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            EGRNRQ+RRM   +G    ++ R   G   L ++ NGE+R + 
Sbjct: 207 NEGRNRQIRRMFDFIGHHVEKIKRVEYGPLKL-DVENGEFRLLN 249


>UniRef50_Q2K4S3 Pseudouridine synthase n=10 Tax=Rhizobiaceae RepID=Q2K4S3_RHIEC
          Length = 312

 Score =  218 bits (555), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 54/218 (24%), Positives = 91/218 (41%), Gaps = 20/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +   T+   S         +           +    ++ NKP  ++    D  GR T
Sbjct: 95  RVAVDGRTVSDASAWV--DLSTARISVDGLVIAAEAKIYLMLNKPRGLVTTRQDPEGRPT 152

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + +       +   GRLD+ SEGLL+ TN+      L  P     K Y+VQ++ +   
Sbjct: 153 VYDCLKNFDIPHLSPVGRLDKASEGLLLFTNDTEFAQTLLDPLTHVTKTYHVQIDRLMDD 212

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + + A+ +G+  +      A    +               R+    SW+++ L EGRNRQ
Sbjct: 213 EEIAAMTSGIRHDGELLTAAATRRL---------------RQGDRNSWIEVELDEGRNRQ 257

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +RRM   +G   LRL+R A+G   L  L  G  R +T+
Sbjct: 258 IRRMLEALGAECLRLVRVAIGGLELGELPKGAVRALTE 295


>UniRef50_A5KLG0 Pseudouridine synthase n=8 Tax=Bacteria RepID=A5KLG0_9FIRM
          Length = 261

 Score =  217 bits (554), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 65/229 (28%), Positives = 107/229 (46%), Gaps = 18/229 (7%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++    +K   +               K         + NKP  V+    D+  R T+
Sbjct: 29  VSVNGEIAKKAERKV--DTEKDEIIFKGEKIFYAGYEYFMLNKPAGVVSATEDKKER-TV 85

Query: 64  KEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + I     + ++ AGRLD+D+EGLL++TN+G L  RL  P K   KIYY +++GI T++
Sbjct: 86  IDLIKESKRKDLFPAGRLDKDTEGLLLITNDGQLAHRLLSPKKHVDKIYYAKIKGIVTEE 145

Query: 121 ALEALRNGVTLND-GPTLPAGAELVD----------EPAWLWPRNPPIRERKSIPTSWLK 169
            +     GV + D  PT+PA  E++           +   + P      + K    S + 
Sbjct: 146 DVRLFEKGVHIGDEKPTMPAALEILSVQKERRKEKIKEQKILPETKNETDEKEDGYSEIY 205

Query: 170 ITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           +T+ EGR  QV+RM   VG   + L R   G  +LD +L  G++R++T+
Sbjct: 206 LTIKEGRFHQVKRMFRAVGKEVVYLKRIQFGTLTLDPSLKPGQYRKLTE 254


>UniRef50_A3HY40 Pseudouridine synthase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HY40_9SPHI
          Length = 434

 Score =  217 bits (554), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 53/217 (24%), Positives = 97/217 (44%), Gaps = 23/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +      +V +F       +K   +    +L NKP D +    D   RKT+
Sbjct: 228 VSVNGKVVTEL---GLKVSKFDRVVYQGKKINPEKPVYVLLNKPKDFITTTDDPLERKTV 284

Query: 64  KEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
              +     + ++  GRLDR++ GLL+ TN+G L A+L+ P  +  KIY V ++   T +
Sbjct: 285 MALVGNACEERIFPVGRLDRNTTGLLLFTNDGELAAKLSHPSNQIKKIYQVTLDKPLTHN 344

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             + +  G+TL DG       +++                 S+    L + ++ G+NR V
Sbjct: 345 DEKDILEGLTLEDGEVEVDDMQVL-----------------SVDRKILGLEIHVGKNRIV 387

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+ AH+G+    L R         +L  G +R +++
Sbjct: 388 RRIFAHLGYEVTALDRVMYAGLDKKDLKRGNYRFLSE 424


>UniRef50_A2RP35 Pseudouridine synthase n=172 Tax=Firmicutes RepID=A2RP35_LACLM
          Length = 328

 Score =  217 bits (554), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 61/219 (27%), Positives = 104/219 (47%), Gaps = 16/219 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++    +   F+  +  R        +  + Q     L NKP  V+    D    KT
Sbjct: 112 RVTVAGEIQRDGRFQVDKNSR--QVAFDGQILDYQEYYYYLLNKPQGVVSATKDNV-FKT 168

Query: 63  LKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +      + ++  GRLD+++EGLL+LTN+GAL   LTQP K   K Y+ +++G  T
Sbjct: 169 VVQLLSEKDFRKDIFPVGRLDKNTEGLLILTNDGALGHDLTQPKKHVEKEYFARIDGKVT 228

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            + +     G+TL +G            P  L+       + +S   S +++ ++EG+  
Sbjct: 229 DEIINKFAEGLTLKNGEKA--------RPGELFVEKTYKGDSQSGWVSEIRVIIHEGKFH 280

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QV+RM   V    L L R  MG+ +LD +LA G +R +T
Sbjct: 281 QVKRMFEAVEMYVLYLKRIRMGNLALDSDLALGAYRPLT 319


>UniRef50_A1ZI67 Pseudouridine synthase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZI67_9SPHI
          Length = 391

 Score =  217 bits (553), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 50/217 (23%), Positives = 99/217 (45%), Gaps = 23/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +      QV    + +  +R  + +    +L NKP D +    D   RKT+
Sbjct: 185 ISVNGKVITE---MGFQVSPTDTVKYGKRLLKREKFVYVLLNKPKDFITTTNDPQDRKTV 241

Query: 64  KEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + I     + +Y  GRLDR++ GLL+ TN+G +  +L+ P     K+Y V+++     +
Sbjct: 242 MDLIKNSCDERIYPVGRLDRNTTGLLLFTNDGEVAKKLSHPSHDVKKVYQVELDKPLKDE 301

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+++  GV L DG        +++                    + + + ++ GRNR V
Sbjct: 302 DLDSIAEGVILEDGYAAVDEIAILNPER-----------------TLVGVEIHIGRNRIV 344

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+  H+ +  ++L R      +  N+  G+WR +++
Sbjct: 345 RRIFNHLDYEVVKLDRTMYAGLNKKNIDRGDWRYLSE 381


>UniRef50_A5V220 Pseudouridine synthase n=5 Tax=Bacteria RepID=A5V220_ROSS1
          Length = 624

 Score =  217 bits (553), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 65/217 (29%), Positives = 105/217 (48%), Gaps = 19/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRK 61
           + +++   ++    R              R       R  ++ +KP  V+    D  GR 
Sbjct: 29  RVMVNGKVVRIPGTRV--DPEHDEILVDGRPIGKIHHRTYVMLHKPAGVVSTTDDPQGRP 86

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + +   Q ++  GRLD DSEGLL+LT++G L  +LT P  +  K Y V +   P+  
Sbjct: 87  TVIDLVNLEQRLFPVGRLDYDSEGLLLLTDDGELTQKLTHPSYQVEKEYRVLLNEAPSPA 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           AL A R GV L+   T PA  EL++               ++   +W+++ L+EGR RQ+
Sbjct: 147 ALRAWRTGVELDGVKTAPAWVELIE---------------RTPDGAWVRVILHEGRKRQI 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R +   +G+   RLIR   G  +L +L +G WR +TD
Sbjct: 192 REVARVLGYEVRRLIRVREGPLTLGDLPSGTWRFLTD 228


>UniRef50_Q1GHH2 Pseudouridine synthase n=12 Tax=Bacteria RepID=Q1GHH2_SILST
          Length = 221

 Score =  217 bits (553), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 112/180 (62%), Positives = 142/180 (78%), Gaps = 4/180 (2%)

Query: 40  RVILFNKPYDVLPQFTD----EAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQ 95
           R+I FNKP+DVLPQFTD     + R TL +++   GVY AGRLDRDSEGL++LT+NG LQ
Sbjct: 3   RLIRFNKPFDVLPQFTDRGSEGSPRATLSDYVDCPGVYPAGRLDRDSEGLMLLTDNGRLQ 62

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
           A ++ P  +  K Y+VQVEGIPT+DAL+ALR GV L DG T PA AEL+ EPA LW R P
Sbjct: 63  AWISDPKHKLEKTYWVQVEGIPTEDALKALRQGVDLKDGMTRPAKAELISEPAQLWARTP 122

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           PIRERKS+PT+WL++ + EG+NRQVRRMTA +G+PTLRLIRYA+G ++LD LA G+W ++
Sbjct: 123 PIRERKSVPTAWLELKISEGKNRQVRRMTAAMGYPTLRLIRYAIGAWTLDGLAQGKWDDL 182


>UniRef50_A6C4P7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C4P7_9PLAN
          Length = 352

 Score =  217 bits (553), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 66/217 (30%), Positives = 110/217 (50%), Gaps = 19/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +  + + +   +     +F        +   QP R  L NKP   L    D AGR+ 
Sbjct: 48  RVSVDGDVITELGAKIDPETQF--IEVDGERVRLQPRRYYLLNKPSGFLCTNNDPAGRRR 105

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + +  P   Q ++  GRLD +SEGL+++TN+G L  RL  P  R  + Y+VQV G P ++
Sbjct: 106 VVDLFPNDGQRLFTVGRLDENSEGLILVTNDGELAQRLAHPRYRVARTYHVQVVGNPPRE 165

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ LR GV   +G    +G + +               +K   +++L++TL+EG+NR++
Sbjct: 166 KLDELRKGVRFKEGVFRVSGLKYL---------------KKQGKSAFLELTLHEGQNREI 210

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RRM A +G   ++L+R   G  +L  L  GE R ++D
Sbjct: 211 RRMMARIGHKVIQLVRIRFGPLNLGKLKTGESRRLSD 247


>UniRef50_Q2JQ37 Pseudouridine synthase n=10 Tax=Bacteria RepID=Q2JQ37_SYNJB
          Length = 226

 Score =  216 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 101/178 (56%), Positives = 128/178 (71%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           R + F KPY VL QFTD  GR TL+ FIPV  VY  GRLDRDSEGLL+LT++G L ARL 
Sbjct: 29  RYLKFYKPYGVLTQFTDREGRPTLQSFIPVPRVYPVGRLDRDSEGLLLLTDDGRLNARLI 88

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P     +IY+VQVEGIPT  AL+ L+ G+ +    T PA  +++ E   L PR+PPIR 
Sbjct: 89  DPKFGHERIYWVQVEGIPTPQALQQLQQGLIIQGRKTRPAQVKVLAEEPTLPPRDPPIRF 148

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R+SIPT+WL++TL EGRNRQVRRMTA VG PTLRL+R  +G  SL  LA G+W+++++
Sbjct: 149 RRSIPTTWLELTLREGRNRQVRRMTAAVGIPTLRLVRVGLGPLSLAGLAPGQWQDLSE 206


>UniRef50_A0L6G3 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L6G3_MAGSM
          Length = 332

 Score =  216 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 72/220 (32%), Positives = 103/220 (46%), Gaps = 22/220 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR--VILFNKPYDVLPQFTDEAGR 60
           +  I+   + +      +V +        +    Q +R   I+ +KP  ++   +D  GR
Sbjct: 95  RVSINGEVVTELGV---KVAKRDRVAVDGQLVTPQRSRDTAIILHKPKSIICTRSDPQGR 151

Query: 61  KTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           +T+ + I       +   GRLD +SEGL++LT++G L   L  P +   ++Y V+  GI 
Sbjct: 152 RTIFDLIENHGSSRLITVGRLDINSEGLIILTSDGQLAHGLMHPSREVPRVYRVKTHGIL 211

Query: 118 TQDALEALRN-GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
               LE +R  GV L DGPT P    L              R R+    SW  ITL EGR
Sbjct: 212 LASQLEQIRTVGVRLEDGPTGPLEIVL-------------DRGREQGNNSWYTITLREGR 258

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           NR+VRR+  H G    RL+R   G  SL NL  G WR VT
Sbjct: 259 NREVRRIFDHFGLQVARLLRVGYGGISLGNLEPGAWRPVT 298


>UniRef50_A4BW35 Pseudouridine synthase n=3 Tax=Flavobacteriaceae RepID=A4BW35_9FLAO
          Length = 305

 Score =  216 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 59/217 (27%), Positives = 97/217 (44%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++ N + +     ++V+     R        +  + IL NKP + +    D+ GRKT+
Sbjct: 98  VEVNGNLVTE---MGYKVQPDDVVRFDGTGITPEQKKYILLNKPKNYITTMDDDRGRKTV 154

Query: 64  KEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + I     + +Y  GRLDR++ GLL+ TN+G L  +LT P     K+Y+  ++      
Sbjct: 155 MDLISNATKERIYPVGRLDRNTTGLLLFTNDGELAKKLTHPKHDVRKLYHASLDKKLELK 214

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            LE LR  V +            VD                  P S + I ++ GRNR V
Sbjct: 215 DLEKLRGEVLIEGKKVFIDAVSYVD----------------GQPKSEVGIEIHSGRNRIV 258

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R++  H+G+   +L R    + +  NL  G WRE+T+
Sbjct: 259 RKIFEHLGYKVSKLDRVIFAELTKRNLPRGRWRELTN 295


>UniRef50_Q38VQ0 Pseudouridine synthase n=6 Tax=Lactobacillus RepID=Q38VQ0_LACSS
          Length = 239

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 56/219 (25%), Positives = 93/219 (42%), Gaps = 23/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++  +++     +QV   +           Q     L NKP  V+   TD    KT
Sbjct: 26  RVRVADKVIKEAK---YQVTPETVVYVDDEPIRYQTNFYWLLNKPAGVISATTDPQ--KT 80

Query: 63  LKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + +        + ++  GRLD+D+ GLL++TN+G L   L  P K   K Y  ++ G+ T
Sbjct: 81  VMDLFAPADYREDLFPVGRLDKDTTGLLLITNDGDLAHDLLSPKKHVAKTYRAKIAGVVT 140

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
                    G+ L D    PA   ++                     S +++ ++EG+  
Sbjct: 141 AADQAQFAAGLKLRDFDAQPAQLTILRTDTARQE-------------SLIEVEIHEGKFH 187

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QV+RM   VG   L L R  MG  SL  +L  G++R +T
Sbjct: 188 QVKRMFHAVGKEVLTLERIKMGPLSLPADLKRGQYRALT 226


>UniRef50_Q12AB3 Pseudouridine synthase n=8 Tax=Proteobacteria RepID=Q12AB3_POLSJ
          Length = 544

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 61/227 (26%), Positives = 98/227 (43%), Gaps = 25/227 (11%)

Query: 1   MRQFIISENTMQ--KTSFRNHQVKRFSSQRSTRR----KPENQPTRVILFNKPYDVLPQF 54
           M Q I+        + +    +++   + +   +    + +  P RVI ++KP   +   
Sbjct: 114 MEQLILEGRISVNAEPAHIGQRIQFGDTVKVNGKPIRVRIDPPPPRVIAYHKPSGEVVTH 173

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D   R T+   +P        + GRLD ++EGLL+LT++G L  +L  P     + Y V
Sbjct: 174 DDPQNRPTVFRRLPKLFQGKWQSVGRLDLNTEGLLLLTSSGELANKLMHPRFGLEREYAV 233

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +V G  + +  + L  GVTL+DG    +  E                        W ++T
Sbjct: 234 RVLGALSNEEKKRLLEGVTLDDGVAQFSSIE---------------AGGGEGANCWYRVT 278

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           + EGRNR+VRRM   VG    RLIR   G   L   L  G + E+ +
Sbjct: 279 ISEGRNREVRRMFEAVGHAVSRLIRIRYGAMLLPRGLKRGAFVELDE 325


>UniRef50_C1ZE67 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZE67_PLALI
          Length = 554

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 61/219 (27%), Positives = 99/219 (45%), Gaps = 19/219 (8%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           M +  I     ++   R    ++         K   +  R  LF+KP  VL   +D AGR
Sbjct: 60  MGRVTIDGVVAKELGVRVDLSRQ--KVAVDGEKLRVEEKRYFLFHKPAGVLCTNSDPAGR 117

Query: 61  KTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
             + +  P     ++  GRLD  +EGLL++TN+G L  RLT P     +IY   V G P+
Sbjct: 118 TRVIDCFPPNVGRLFTVGRLDDGTEGLLIVTNDGDLAERLTHPKFGIPRIYRAVVAGNPS 177

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            +A+  L  G+   +G    +    V               +     + L+IT+ EG+NR
Sbjct: 178 TEAINQLLEGLYFAEGRFRMSSVNRV---------------KSQGSATVLEITMREGQNR 222

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           ++RR+ A VG   ++L R   G   L +L  G  R++++
Sbjct: 223 EIRRLLARVGHKVMKLKRTHFGPIKLGDLERGAHRKLSE 261


>UniRef50_Q2NIZ3 Pseudouridine synthase n=5 Tax=Candidatus Phytoplasma
           RepID=Q2NIZ3_AYWBP
          Length = 245

 Score =  216 bits (551), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 53/217 (24%), Positives = 92/217 (42%), Gaps = 17/217 (7%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           ++  ++   +   S    +V          +          L NKP   L    D+  R 
Sbjct: 26  KRIKVNGKII---SELGTKVSSSDIITLDDKPITKATYSYFLLNKPNGFLSTAKDKKNRP 82

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + I     Q +Y  GRLD ++ GLL++TN+G L  +LT P     K Y+V++     
Sbjct: 83  TVLDLIEEASIQRLYPIGRLDFNTTGLLLITNDGDLTQKLTHPSFCIPKEYHVKINACLQ 142

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           +  L     G+ ++                     +         P++WLK+ + EG+NR
Sbjct: 143 KKDLSTFCKGIIIDKKYLAVCK-----------EIDILKISYMPKPSTWLKLVITEGKNR 191

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           QVR+M   +G+  L+L RY     +++NL  G +R +
Sbjct: 192 QVRKMMQALGYQVLKLKRYRYSFLTIENLTIGAYRPL 228


>UniRef50_B1XK09 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XK09_SYNP2
          Length = 223

 Score =  215 bits (549), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 95/187 (50%), Positives = 122/187 (65%), Gaps = 8/187 (4%)

Query: 38  PTRVILFNKPYDVLPQFTD----EAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGA 93
               +L +KPY+VL QFTD     + R+TLK+F+PV  +Y+ GRLD DSEGLL+LTN+  
Sbjct: 2   QHSYVLLHKPYNVLCQFTDNSPQGSQRQTLKDFVPVPDIYSVGRLDLDSEGLLLLTNDAP 61

Query: 94  LQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
           L+  L +P     + Y+VQVE IP   ALE LR GV +    T PA A L+     +  R
Sbjct: 62  LKHYLCEPKFAHSRTYWVQVENIPDGQALEQLRQGVMVQGKKTRPAIANLLTPEPTVPAR 121

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG----DYSLDNLAN 209
            PPIR RK++PT+WL++TL EGRNRQVRRMTA VG PTLRL+R A+G      +L  L  
Sbjct: 122 EPPIRFRKNVPTAWLELTLTEGRNRQVRRMTAAVGHPTLRLMRVAIGAGPAKLTLTGLGP 181

Query: 210 GEWREVT 216
           GEWR +T
Sbjct: 182 GEWRHLT 188


>UniRef50_Q01Z61 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Z61_SOLUE
          Length = 264

 Score =  215 bits (549), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 63/217 (29%), Positives = 98/217 (45%), Gaps = 21/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRF-SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +       H V           +  +      IL  KP   L  + D  GR 
Sbjct: 39  KVRVNGKVVLNPD---HWVDPDHDKVTLEGKPLKAATKSYILLYKPKGYLTTYRDPEGRP 95

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+   +    + +   GRLD D+ GLLVLTN+     R+T P  +  K Y ++   + + 
Sbjct: 96  TVYALLGDVGKWLSPVGRLDLDTSGLLVLTNDNDFAERITNPEHKVPKTYQIKAATVLSD 155

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + +E LR GV L+DGPT PA  + +               R     ++L++T+ EGRNRQ
Sbjct: 156 EQIERLRAGVELSDGPTRPAEVKRL---------------RDGPKHTFLEMTITEGRNRQ 200

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM   V     +L+R A+G   +  L  G+WR +T
Sbjct: 201 VRRMLEAVESKVSKLVRTAIGPVRIGELPIGKWRNLT 237


>UniRef50_B9KY92 Pseudouridine synthase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KY92_THERP
          Length = 282

 Score =  215 bits (548), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 66/215 (30%), Positives = 102/215 (47%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +++   +              +   ++P R I+ +KP   +    DE GRKT
Sbjct: 33  RVTVDGVVVRELGRKV--DPERQEICVDGKPLHSEPRRYIVLHKPVGYITTTADEYGRKT 90

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +   + V   GRLDRDS GLL+LTN+G L  R+T P     K Y V V+G P  + 
Sbjct: 91  VLDLVQVPERVVPVGRLDRDSSGLLLLTNDGDLIYRITHPRYELEKEYEVLVDGFPPPEV 150

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
            EALR GV ++  P      E +               R     +  ++ ++EGRNR +R
Sbjct: 151 EEALRRGVPVDGRPVRIRRLEAI---------------RVEPQGTVYRVVIHEGRNRIIR 195

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R+   VG+P LRL R  +G   L +L  G WR++T
Sbjct: 196 RVFERVGYPVLRLQRVRVGPLRLGDLPPGRWRDLT 230


>UniRef50_Q6SI36 Pseudouridine synthase n=1 Tax=uncultured marine bacterium 105
           RepID=Q6SI36_9BACT
          Length = 255

 Score =  215 bits (548), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 16/217 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++  ++ K   +          R   RK +  +P   +L  KP   +    D  GR+
Sbjct: 31  RVTVNGRSVTKLGAK--ADPDLDDIRVDGRKVKTGRPRIYLLVCKPRGYVTTRFDPEGRR 88

Query: 62  TLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+   I      VY  GRLD DSEGL++LTN+G L ARLT P     ++Y V+V G+P+Q
Sbjct: 89  TILNLISNVREYVYPVGRLDYDSEGLVILTNDGTLAARLTHPRYGVERVYEVRVRGVPSQ 148

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            A+++LR+GV +N   T  +  + +              + KS   + L++ + EGRNRQ
Sbjct: 149 AAIDSLRHGVLINGRRTASSSVKFLRR-----------LKAKSSENALLRVAIREGRNRQ 197

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VR+M   +G P +RL R  +G     +L  G+ R +T
Sbjct: 198 VRKMCEAIGHPVIRLRRTQIGPLRDSSLKVGKHRLLT 234


>UniRef50_D2B9T7 Pseudouridine synthase n=18 Tax=Actinobacteria (class)
           RepID=D2B9T7_STRRD
          Length = 621

 Score =  215 bits (548), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 61/216 (28%), Positives = 94/216 (43%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +++   R    K+       +R P       +  NKP  V+   +D  GR +
Sbjct: 409 RVTVDGQVVRRFGARVDPAKQVIHV-DGKRLPTMPDLVYLAINKPIGVVSTMSDPDGRPS 467

Query: 63  LKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           L +F+    + ++  GRLD ++EGL++LTN+G L  RLT P     K Y+ +V G   +D
Sbjct: 468 LADFVADRTERLFHVGRLDTETEGLILLTNDGELANRLTHPSYGVQKKYWAKVPGRIERD 527

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
               L+ G+ L DG        LV E                   + +++ L+EGR   V
Sbjct: 528 LGRRLKKGIELEDGIAKADSFTLVQE---------------HGQQALVEVVLHEGRKHIV 572

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   VG P + L R   G   L  L  G  R +T
Sbjct: 573 RRMLEEVGHPVIDLARIEFGPVKLGRLKPGTVRALT 608


>UniRef50_Q01SF5 Pseudouridine synthase n=3 Tax=Bacteria RepID=Q01SF5_SOLUE
          Length = 249

 Score =  215 bits (548), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 60/218 (27%), Positives = 93/218 (42%), Gaps = 21/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++ + + +   +    +     +   R  +  +    I  NKP   +    D  GR+
Sbjct: 29  RVTVNGSVITELGSKADLDR--DHIKVDGRLLKAPKHQIYIALNKPKGTVTTVHDPEGRE 86

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +    + VY  GRLD  SEGLL+LTN+G L   +        K Y V+V G  T 
Sbjct: 87  TVMDLLHRVKERVYPVGRLDYHSEGLLLLTNDGELANSIMSAATHLEKTYVVKVTGTLTA 146

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +  E  R GV L+   TLPAG +L+                      W ++ L EGRN Q
Sbjct: 147 EQEEKFRTGVPLSGRRTLPAGLKLLSRAE----------------NPWYEVKLTEGRNNQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +R M  H G    +L R  +G   L  L  G +R + +
Sbjct: 191 IRMMFRHFGKLVEKLKRVRIGPIELGTLKTGAFRYLDE 228


>UniRef50_B9KC52 Pseudouridine synthase n=1 Tax=Thermotoga neapolitana DSM 4359
           RepID=B9KC52_THENN
          Length = 240

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 105/217 (48%), Gaps = 24/217 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++ T+   +   +++      +   +  +      ILF KP   +    D    +T
Sbjct: 26  RVTVNDRTVLDPA---YKLSDKDVVKVDGKVIDLPEKVYILFYKPAGYVTSTRDPHS-ET 81

Query: 63  LKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + EF+P  +G++  GRLD+D+EGLL++TN+G    R+  P  +  K Y V+VEG  T+D 
Sbjct: 82  IMEFLPDIKGIFPVGRLDKDAEGLLLVTNDGEFAHRVISPRWKVEKEYVVKVEGEITEDK 141

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           LE LR GV+L DG    A                     + I    +KI + EG+  QV+
Sbjct: 142 LEKLRRGVSLRDGFFAKAK------------------HVEKISNDTVKIVITEGKYHQVK 183

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           RM A VG  T+ L R  +G   L   +  GE+R +++
Sbjct: 184 RMMAAVGLKTIHLKRVRIGGLRLPQEMKPGEYRFLSE 220


>UniRef50_C4Z9Y4 Pseudouridine synthase n=16 Tax=Bacteria RepID=C4Z9Y4_EUBR3
          Length = 250

 Score =  214 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 62/219 (28%), Positives = 97/219 (44%), Gaps = 24/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  I+     K   +              R  + Q     LFNKP   +    D     T
Sbjct: 37  QIAINGTVAAKPETKV--DTDADEVSVNGRIVKYQRYEYYLFNKPSGCVSATCDNV-HDT 93

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + ++I       ++  GRLD D+EGLL++TN+GAL   L  P K   K YY +++G  T 
Sbjct: 94  VMDYITDAVHDDLFPVGRLDIDTEGLLLITNDGALSHELLSPSKHVAKTYYARIDGEVTL 153

Query: 120 DALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           D +   + G+ +  + PT PA   +                +KS   S +++T+ EG+  
Sbjct: 154 DDIIRFKEGIDIGEEKPTKPAELVI----------------KKSGSVSEIELTITEGKFH 197

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           QV+RM   +G   + L R +MG   L D+L  G +R +T
Sbjct: 198 QVKRMFEALGKRVIYLKRISMGPLKLPDDLKTGTYRALT 236


>UniRef50_UPI00016C3D27 ribosomal large subunit pseudouridine synthase B n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3D27
          Length = 271

 Score =  214 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 67/218 (30%), Positives = 102/218 (46%), Gaps = 21/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQR-STRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++     K +    ++   + Q     +    +       NKP   L    D AGR 
Sbjct: 27  RVKVNG---VKVTELGLKIDPSAHQIAVDDQPVRAEKLVYWAVNKPVGHLCTNHDPAGRP 83

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
              + +P   Q VY  GRLD  S+GLL++TN+G L   LT P     K+Y+V V G PT 
Sbjct: 84  RAVDLLPHVEQRVYTVGRLDEGSDGLLLMTNDGDLAQGLTHPRYGVPKMYFVLVAGRPTD 143

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           D L+ L +GV L+DG      A+ +               +     +W+++ L EG+NR+
Sbjct: 144 DDLQKLMDGVWLSDGKVRAKSAKRI---------------KAQGNGTWVRVVLTEGKNRE 188

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +RRM A  G   +RL R A+G   LD L  G+ R ++D
Sbjct: 189 IRRMLAKFGHKVMRLKRVAIGPVKLDKLPKGKARRISD 226


>UniRef50_B0MSS4 Pseudouridine synthase n=1 Tax=Alistipes putredinis DSM 17216
           RepID=B0MSS4_9BACT
          Length = 451

 Score =  214 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 57/202 (28%), Positives = 91/202 (45%), Gaps = 20/202 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV---QGVYA 74
             +V+     +    + E +    ++ NKP   +    D    KT+ E +     + +Y 
Sbjct: 254 GTKVQPTDEVKFNDSRVEGEKKVYLVLNKPKGYVTSLDDPHADKTVMELVKDACTERIYP 313

Query: 75  AGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDG 134
            GRLD++S GLL+ TN+G L  +LT P  +  KIY V ++   T+  +E +  G+TL DG
Sbjct: 314 VGRLDKNSVGLLLFTNDGDLTRQLTHPSFQKKKIYQVSLDKPLTKADMEQIAQGITLEDG 373

Query: 135 PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRL 194
                    V E                   + + I ++ GRNR VRR+  H+G+   +L
Sbjct: 374 EIYADEIAYVKE-----------------DKTEVGIEIHSGRNRIVRRIFEHLGYAVKKL 416

Query: 195 IRYAMGDYSLDNLANGEWREVT 216
            R      S  NL  G+WR +T
Sbjct: 417 DRVYYAGLSKKNLKRGQWRFLT 438


>UniRef50_Q8ZGM2 Ribosomal small subunit pseudouridine synthase A n=134
           Tax=Gammaproteobacteria RepID=RSUA_YERPE
          Length = 235

 Score =  214 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 30/222 (13%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGR 60
           ++  I    ++  +    ++      R      +     R  + NKP   +    D    
Sbjct: 25  KRVTIDGEVVKSGAI---KLTPEQDVRFDGNPLQQMVGPRYFMLNKPQGYVCSTEDP-DH 80

Query: 61  KTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            T+  F+       ++AAGRLD D+ GL+++T++G    R+T P     K Y V +E   
Sbjct: 81  PTVLYFLDEPVAYKLHAAGRLDIDTTGLVLMTDDGQWSHRVTSPRHHCEKTYLVTLEHPL 140

Query: 118 TQDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
           + D  +   +GV L +    T PA  ++++                      +++T+ EG
Sbjct: 141 SDDTAQQFADGVQLYNEKSLTKPAQLDVIEPQR-------------------VRLTISEG 181

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           R  QV+RM A VG   + L R  +GD +L D+LA GE+R +T
Sbjct: 182 RYHQVKRMFAAVGNRVIELHRERIGDITLDDDLAPGEYRPLT 223


>UniRef50_A5IKF7 Pseudouridine synthase n=5 Tax=Thermotogaceae RepID=A5IKF7_THEP1
          Length = 239

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 98/216 (45%), Gaps = 22/216 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +       H V                    ILF+KP   +    D      
Sbjct: 26  RVTVNGRVVLDP---GHSVSENDVVVLDGETVNFHRKVYILFHKPSGYVTSTKDPHSETI 82

Query: 63  LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
           ++   P++G++  GRLD+D+EGLL++T++G    R+  P     K Y V+VEG  T+D +
Sbjct: 83  MEFLPPLKGIFPVGRLDKDAEGLLIITSDGDFAHRVISPKWSVEKEYIVKVEGEVTEDKI 142

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
           E L+NGVTL DG    A                     + +    LKI + EG+  Q++R
Sbjct: 143 EKLKNGVTLRDGFFAKAK------------------CVEKLSNDTLKIVITEGKYHQIKR 184

Query: 183 MTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
           MT  VG  T+ L R  +G   L +++  GE+R +++
Sbjct: 185 MTVAVGLRTVHLKRTRIGRLVLPEDMKPGEYRFLSE 220


>UniRef50_C8QZD4 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZD4_9DELT
          Length = 240

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 57/217 (26%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRV-ILFNKPYDVLPQFTDEAGRK 61
           +  +    + +                  +       ++ +L NKP   +    D  GR 
Sbjct: 28  RVQVDGRPVAQMGLTI--DPERQQVTFDGQPVLPPSRKLTVLLNKPAGYVTTMADPQGRP 85

Query: 62  TLKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            +   I  P   ++  GRLD D+EG L+LTN+G L   +  P ++  + Y+  V+G P +
Sbjct: 86  IVTSLINEPGLRLFPVGRLDLDTEGALLLTNDGELAQNILHPSRQINRTYHATVKGRPNR 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +AL+ LR G+ L    T PA    +               R++  ++ L++ ++EGR RQ
Sbjct: 146 EALQQLRRGIMLEGRRTWPARIREL---------------RRNQESTTLEVIIHEGRKRQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VR+M A +  P L+L R A G   L +L  G +R ++
Sbjct: 191 VRKMFAAINHPVLQLKRVAYGGLRLGSLPTGRYRRLS 227


>UniRef50_C5WHE9 Pseudouridine synthase n=3 Tax=Lactobacillales RepID=C5WHE9_STRDG
          Length = 245

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 21/220 (9%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++++        + ++ K         +    +     + NKP   L    D   + 
Sbjct: 27  KAILVNQEVETSPKVQINEHK--DVVTYLGKPLTYEAFVYYILNKPAGFLSATKD-RAQA 83

Query: 62  TLKEFI----PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + +      + V+  GRLD+D+ GLL+LTNNG L   L  P K   K Y  +V GI 
Sbjct: 84  TVIDLLDETARQKDVFPVGRLDKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIM 143

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T    +    G++L D   LPA  E++D+                  T  + IT+ EG+ 
Sbjct: 144 TDADKDDFAKGISLKDHQCLPAKLEVLDKDLSQE-------------TCVVSITIQEGKF 190

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            QV+RM A  G   L L R +MG   LD  LA G++R +T
Sbjct: 191 HQVKRMVAACGKEVLELQRLSMGPLRLDPGLAEGDFRRLT 230


>UniRef50_C4XSY8 Pseudouridine synthase n=11 Tax=Desulfovibrionales
           RepID=C4XSY8_DESMR
          Length = 322

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 19/219 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   + +   R    +   +          +    +  +K   V+   +D  GR T
Sbjct: 34  RVTVNGAVVTEAGLRIDPARDALAVDGAPVNLAPEIPITLALHKKPGVVTTASDPEGRPT 93

Query: 63  LKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +P     + ++  GRLD  SEGLL+LT +G L  RLT P     K Y V V G  T
Sbjct: 94  VFDGLPEVWRGKRLFPVGRLDFFSEGLLLLTTDGELALRLTHPRWHVPKRYRVTVRGQVT 153

Query: 119 QDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
            D L  +  G+ L       P  A +V+ PA                 S L++ L++G N
Sbjct: 154 PDMLGTMARGMRLAEGERLAPVAARVVEGPAQ--------------DRSILEMELHQGVN 199

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RQ+RRM   +G   LRL R + G  +L +L  G  RE+T
Sbjct: 200 RQIRRMCRDLGLTVLRLARVSQGPVALGDLPLGACRELT 238


>UniRef50_Q3J464 Pseudouridine synthase n=15 Tax=Bacteria RepID=Q3J464_RHOS4
          Length = 508

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 103/216 (47%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++  T+   +     V          +     +P R+ L+ KP  ++   +DE GR+
Sbjct: 33  RIAVNGRTIDSPALN---VGPKDRITVDGQPLAPPEPARLWLYYKPEGLVTSASDEKGRE 89

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V + GRLD +SEGLL+LTN+G L+ RL  P     + Y V+V+G PT 
Sbjct: 90  TVFDHLPEGMPRVMSVGRLDLNSEGLLLLTNDGELKRRLELPSTGWLRKYRVRVKGNPTD 149

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             LE LR G+T+      P    L               +R     +WL + L EG+NR+
Sbjct: 150 ADLEPLRKGITVEGESFQPMTVSL---------------DRVQGANAWLTVGLREGKNRE 194

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +RR  + +G    RLIR + G + L+ L  G   EV
Sbjct: 195 IRRAMSALGLTVNRLIRVSYGPFRLNELEPGMVEEV 230


>UniRef50_C7PP04 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PP04_CHIPD
          Length = 516

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 63/221 (28%), Positives = 97/221 (43%), Gaps = 25/221 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + + +F   +V          RK   Q     IL NKP   +    D  GRK
Sbjct: 305 KVTVNGELITEPAF---KVTAKDEVAINNRKINIQKNLVYILLNKPKGYITTTDDPEGRK 361

Query: 62  TLKEFI-----PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ E I       Q VY  GRLDR++ GLL+LTN+G L  +L  P     KIY+V +   
Sbjct: 362 TVMELIQDATTEEQRVYPVGRLDRNTSGLLLLTNDGELAQKLAHPKHNIKKIYHVGLNKP 421

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            T+   E +  GVTL DG         V                ++   + + I ++ G+
Sbjct: 422 LTKAHFENILQGVTLEDGVANVDALGYV----------------EAGDKTQVGIEIHSGK 465

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           NR VRR+  H+ +   +L R      +  N+  G+WR +T+
Sbjct: 466 NRIVRRIFEHLEYEVEKLDRVTYAGLTKKNINRGKWRFLTE 506


>UniRef50_Q7UUP0 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UUP0_RHOBA
          Length = 395

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 54/215 (25%), Positives = 96/215 (44%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +   T+ +              R        Q     + NKP  ++    D  GR  
Sbjct: 50  RVDVDGETITELGTTV--DPDLQKVRVDGNYLRPQKLVYYVVNKPVGIVTTNRDPRGRPR 107

Query: 63  LKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +P  + V+  GRLD  SEGL++LTN+G L  +L  P     K+Y V V G    + 
Sbjct: 108 VIDLVPPTERVFPVGRLDISSEGLILLTNDGDLAQKLAHPKFGIQKVYRVVVAGEVRGET 167

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           ++ +R G+ + +G     GA+++               +     + ++I L EG+NR++R
Sbjct: 168 MKKMREGIYIAEGLVQVDGAKII---------------KARTKATEMEIRLKEGKNREIR 212

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R+ A  G    +L R A+G   L ++  G +R++T
Sbjct: 213 RILARFGHKVQQLRRVAIGPLKLGDVPRGAYRKLT 247


>UniRef50_A5TWE7 Pseudouridine synthase n=10 Tax=Fusobacterium RepID=A5TWE7_FUSNP
          Length = 234

 Score =  214 bits (545), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 23/218 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE---NQPTRVILFNKPYDVLPQFTDEAG 59
           +  ++ NT    +     +    +     +K +   N+     + NKP +VL   +D+ G
Sbjct: 26  RITVNGNT----ATTGMDINENDNIFIDGKKIKTSINEEKVYFMLNKPLEVLSSSSDDRG 81

Query: 60  RKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           RKT+ + I   + ++  GRLD  + GL++LTN+G L  R+  P     K YY+++ G   
Sbjct: 82  RKTVVDLIKTDKRIFPIGRLDYMTSGLILLTNDGELFNRVVHPKSEIYKKYYIKILGELK 141

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++ ++ L+ GV L+DG TLPA    +               +     + + I++ EGRNR
Sbjct: 142 KEEIDELKKGVLLDDGKTLPAKISGI---------------KYDKNKTSMFISIREGRNR 186

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           Q+RRM     +  L L R  +G+ +L +L  G++RE+T
Sbjct: 187 QIRRMIEKFEYKVLMLRREKIGELALGDLPEGKYRELT 224


>UniRef50_A8SYF2 Pseudouridine synthase n=1 Tax=Coprococcus eutactus ATCC 27759
           RepID=A8SYF2_9FIRM
          Length = 239

 Score =  213 bits (544), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 57/221 (25%), Positives = 103/221 (46%), Gaps = 19/221 (8%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +++ ++S N     S      +   + +   ++      R  L NKP   +    D    
Sbjct: 22  IKKGMVSVNGTNAASSDMKINEDTDTIKYNGKQLCYSKYRYFLLNKPAGCVSATKDNV-H 80

Query: 61  KTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           +T+ + +  +    ++  GRLD D+EGLL++TN+G L   L  P     K YY  ++G  
Sbjct: 81  QTVIDLLNGENTKDLFPVGRLDLDTEGLLIITNDGRLAHHLLSPAHHIAKTYYADIDGYV 140

Query: 118 TQDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
               +   + G+ + +D PTLPA  ++++               +S  +S +++T+ EGR
Sbjct: 141 DDQTISLFKQGIDIGDDTPTLPASLKIIEAD-------------RSTGSSRIELTITEGR 187

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
             QV+RM   V      L R +MG+  + D+L  G +RE+T
Sbjct: 188 FHQVKRMFQAVNMSVTFLKRISMGNLHIADDLPTGSYRELT 228


>UniRef50_C4FUC8 Pseudouridine synthase n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FUC8_9FIRM
          Length = 243

 Score =  213 bits (544), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 61/221 (27%), Positives = 98/221 (44%), Gaps = 21/221 (9%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +   I++    K   +              +    Q     L NKP  +L    D    +
Sbjct: 25  KIVTINDQVCSKGGTQVTPGS--DCVAVGGQLVPYQRYHYYLLNKPEGILSATED-RHHQ 81

Query: 62  TLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ +++        ++  GRLD D+ GLL+LTNNG L  +L  P K+  K Y   + G+ 
Sbjct: 82  TVIDWLGEGYQHLDLFPVGRLDIDTTGLLLLTNNGQLAHQLLSPKKKVDKTYTATIRGLV 141

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
            Q  + A   G+ L D  +LPA   ++ +                  TS +++ + EG+ 
Sbjct: 142 DQADIAAFEAGLDLGDFTSLPAELTVLSQDVDQ-------------GTSQIQVIIQEGKF 188

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
            QV+RM   VG   L L R AMG   L+ +LA+G+WR +T+
Sbjct: 189 HQVKRMFQAVGKEVLSLHRLAMGPLRLESDLAHGQWRSLTE 229


>UniRef50_Q1D5Q2 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q1D5Q2_MYXXD
          Length = 745

 Score =  213 bits (543), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 59/215 (27%), Positives = 98/215 (45%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++  T+ +   R        +   T   P ++ +   L  KP  V+   +D  GR T
Sbjct: 29  RVAVNNKTVTELGSRVEPGTDLVTVDGTLVTPPDESS-YFLLYKPVGVVTTLSDPQGRPT 87

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +  ++    + ++  GRLD D+EG L+ T++GAL  +LT P  +  + Y  +V+G P   
Sbjct: 88  VANYVEETGKRLFPVGRLDYDAEGALLFTDDGALAHKLTHPSFQVPRTYLAKVKGAPDTA 147

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ LR GV L DG   P    +                  +   +WLKI + EGR   +
Sbjct: 148 TLDKLRGGVRLEDGMATPVSVSV---------------FEAAERNTWLKIVVAEGRPHLI 192

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +R+ A VG P +RL R +     ++ L  GE R +
Sbjct: 193 KRLCAAVGHPVVRLFRPSYAGVGVEGLRPGELRPL 227


>UniRef50_B6IXC3 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B6IXC3_RHOCS
          Length = 551

 Score =  213 bits (543), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 102/216 (47%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V+         +  PE +PTRV  ++KP  ++    DE GR 
Sbjct: 56  RVSVNGRVLDTPAVT---VRPGDRIVVDGQPVPEPEPTRVWRYHKPDGLVTTARDEKGRP 112

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P +   V + GRLD  SEGLL+LTN+GAL   L  P     + Y V+V G P +
Sbjct: 113 TVFDNLPPELPRVVSVGRLDLTSEGLLLLTNDGALARHLELPVTGWLRRYRVRVHGAPDE 172

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             +  L  G+ +      P                  + +R     +WL ++L EGRNR+
Sbjct: 173 AQIAKLAQGIIIEGIEYGPIE---------------TVVDRSVGANTWLTVSLREGRNRE 217

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VRR+  H+G P  RLIR A G + L  L  G+  EV
Sbjct: 218 VRRVMEHLGLPVSRLIRVAYGPFQLGKLEPGQVEEV 253


>UniRef50_C6JI84 Pseudouridine synthase n=2 Tax=Fusobacterium RepID=C6JI84_FUSVA
          Length = 236

 Score =  213 bits (542), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 109/217 (50%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN--QPTRVILFNKPYDVLPQFTDEAGRK 61
             I+       +    +V          +K E   +     + NKP +VL    D+ GRK
Sbjct: 30  IKINGE----KATPGIKVSDKDEIYIRGKKIEKHTEKKVYYILNKPLEVLSSSKDDRGRK 85

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + I   + ++  GRLD ++ GL++LTN+G L  R+  P     K YYV+V G   ++
Sbjct: 86  TVVDLINCKERIFPIGRLDYNTSGLIILTNDGELFNRIIHPKAEIFKEYYVKVLGEIKEN 145

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +E L+NGV L+DG TLPA   ++               R+    + L + + EGRNRQV
Sbjct: 146 NVELLKNGVELDDGITLPANVRIL---------------RREKGKTELLVAIREGRNRQV 190

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RRM   +  P + L R  +G+ SL NL  GE+RE+T+
Sbjct: 191 RRMMDKINHPVITLRREKIGNLSLGNLKLGEYRELTN 227


>UniRef50_Q1GFA6 Pseudouridine synthase n=3 Tax=Rhodobacteraceae RepID=Q1GFA6_SILST
          Length = 422

 Score =  212 bits (541), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V             PE +  R+ L+ KP  ++   +DE GRK
Sbjct: 87  RVAVNGKVIDSPALN---VTNLDRIVVDGNPLPEAEAPRLWLYYKPNGLVTTTSDEKGRK 143

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V   GRLD +SEGLL+LTN+G ++ +L  P     + Y V++ G P  
Sbjct: 144 TIFDALPEDLPRVMTVGRLDLNSEGLLLLTNDGGVKRQLELPSTGWLRRYRVRINGRPQD 203

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
              + LR GV ++     P    L               +R+    +WL I L EG+NR+
Sbjct: 204 HEFDVLRKGVVIDGERFQPMTISL---------------DRQQGANAWLTIGLREGKNRE 248

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +RR    VG+P  RL+R + G + L  L  GE  E+
Sbjct: 249 IRRAMEEVGYPVNRLLRISYGPFQLGTLKEGEVEEL 284


>UniRef50_B4D966 Pseudouridine synthase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4D966_9BACT
          Length = 237

 Score =  212 bits (541), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 24/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  I+   +   S    QV    + +   R    +    +L NKP   +   +DE  RKT
Sbjct: 26  QVRINGQVVTDLST---QVGPTDAVKVGSRLLRTEQKITVLLNKPAGYVCTASDERDRKT 82

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P     VY  GRLD+DSEGLL++TN+G L   LT P  +  K Y V ++      
Sbjct: 83  IFDLLPANWPRVYHVGRLDKDSEGLLLVTNDGDLSLALTHPRYKIEKEYEVLLDKPFNPQ 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
             E L  G  +  G       E+++                    + L +TL +G  RQ+
Sbjct: 143 DREKLLKGFHIIGGRAKAERVEILNP-------------------THLSLTLTQGIKRQI 183

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R M   +G+   RL R  +G   +  +  GEWR +T
Sbjct: 184 RLMLYDLGYEVERLARIRLGPLKIGEMRPGEWRLLT 219


>UniRef50_A6G735 Pseudouridine synthase n=2 Tax=Bacteria RepID=A6G735_9DELT
          Length = 300

 Score =  212 bits (540), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 64/218 (29%), Positives = 100/218 (45%), Gaps = 20/218 (9%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFT---DEAGR 60
             ++   +++   R                 + +     + NKP  V+       DE GR
Sbjct: 57  VRVNGQVVRELGTRVFP--ERDRVTVRGEPIQAESKVYYVLNKPDGVVSSAAGSVDERGR 114

Query: 61  KTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
            T+   +    + +Y  GRLD  S G+L+LTN+G L   LT P     K Y+V+ +G  T
Sbjct: 115 PTVISLLHGVSERLYPVGRLDFHSRGVLLLTNDGGLAEALTHPRHGVVKTYHVKFQGKLT 174

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++  + LR+GV L+DG             A   P       R++    W +I + EG NR
Sbjct: 175 EEQEQLLRDGVELDDG-------------AITRPVAELFAFRETATNVWYQIGIREGLNR 221

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           Q+RRM   +G P L+LIR A+GD + D +  GE+R + 
Sbjct: 222 QIRRMGEAIGHPVLKLIRVAIGDITADGVPEGEFRALN 259


>UniRef50_UPI0001BCEF2E pseudouridine synthase n=1 Tax=Selenomonas noxia ATCC 43541
           RepID=UPI0001BCEF2E
          Length = 296

 Score =  212 bits (540), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 62/217 (28%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRK 61
           +  +    + +   +        +     +   +   R  IL NKP   L    D+ GRK
Sbjct: 28  RVAVDGVAVTELGRK--FDPANHTITVDSKPIHSDEKRFYILLNKPRGYLSTARDDRGRK 85

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     +Y  GRLD D+EG+L++TN+GA+   L  P     K+Y+ +V G  T+
Sbjct: 86  TVLDLLPDFPARLYPVGRLDADTEGVLLITNDGAITQGLLHPRFEIDKVYHAEVAGPVTE 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L  LR G+ L DG T  A   ++               R     + ++  ++EGRNRQ
Sbjct: 146 GGLTRLRRGILLEDGMTASAKLRIL---------------RADKGYTVVETIIHEGRNRQ 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM A +G     L R      +L  L+ G +R +T
Sbjct: 191 VRRMFAAIGCRVCALRRVRFAMLTLRGLSCGSFRHLT 227


>UniRef50_A1WE21 Pseudouridine synthase n=1 Tax=Verminephrobacter eiseniae EF01-2
           RepID=A1WE21_VEREI
          Length = 520

 Score =  211 bits (539), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 61/227 (26%), Positives = 96/227 (42%), Gaps = 25/227 (11%)

Query: 1   MRQFIISEN--TMQKTSFRNHQVKRFSSQRSTRR----KPENQPTRVILFNKPYDVLPQF 54
           M Q I+        + +    +++     +   +    + +  P RVI ++KP   +   
Sbjct: 188 MEQLILEGRISVNNEPAHIGQRIQFGDQVKVNGKPIRYRIDPPPARVIAYHKPVGEVVSH 247

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D   R T+   +P        + GRLD ++EGLL+LT++G L  +L  P     + Y V
Sbjct: 248 DDPHNRPTVFRRLPRLVQGKWQSVGRLDLNTEGLLLLTSSGELANQLMHPRFGLEREYAV 307

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +V G  + +  + L +GV L+DG       E                        W ++T
Sbjct: 308 RVLGALSNEEKQKLLDGVRLDDGIASFGTIE---------------DGGGEGANCWYRVT 352

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           + EGRNR+VRRM   VG    RLIR   G   L   L  G W E+ +
Sbjct: 353 IAEGRNREVRRMLEAVGHAVSRLIRIRYGAMVLPRGLKRGTWLELDE 399


>UniRef50_D1AL84 Pseudouridine synthase n=1 Tax=Sebaldella termitidis ATCC 33386
           RepID=D1AL84_SEBTE
          Length = 233

 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 68/219 (31%), Positives = 104/219 (47%), Gaps = 27/219 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++  + +   + H  +         ++ E +    I+ NKP DV+    DE  R T
Sbjct: 26  RISVNDEVVTE--AKTHIDEDNDFVAFDGKRIEFKEFLYIMLNKPQDVISATDDERHR-T 82

Query: 63  LKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +       G++  GRLD+D+EGLLVLTN+G +   L  P K   K YYV+++   +
Sbjct: 83  VLDLLEEPLTKVGLFPVGRLDKDTEGLLVLTNDGKMAHELLSPKKHVPKRYYVELKKTLS 142

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++    L NGV L    T PA  E + E                     + I + EG+  
Sbjct: 143 KEEAAILENGVELETFTTKPAKVEFITED-------------------KVYIIISEGKYH 183

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QV+RM   VG   L L R  MG+  LD NLA GE+RE+T
Sbjct: 184 QVKRMFKCVGNRVLFLKRTGMGNLGLDENLAPGEYRELT 222


>UniRef50_A0JV58 Pseudouridine synthase n=37 Tax=Actinobacteridae RepID=A0JV58_ARTS2
          Length = 406

 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 95/216 (43%), Gaps = 19/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    + +   R             R +  ++    ++FNKP  V+    D  GR  
Sbjct: 193 RVEVDGKVVTELGVRVDPKTAVIHVDGLRIQL-DENMVYMVFNKPKGVVSTMEDPDGRPC 251

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + +F+     + ++  GRLD  +EGLL+LTN+G L  RLT P     K Y VQV G   Q
Sbjct: 252 ISDFVRNTHGERLFHVGRLDVATEGLLLLTNDGELANRLTHPSYEVPKTYLVQVRGPFPQ 311

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
                L+ GV L DG       +LVD                +     +++ L+ G+NR 
Sbjct: 312 GIGAQLKAGVELEDGMASVDSFKLVDS---------------TPGHVLIEVVLHSGKNRI 356

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VRR+   VGFP LRL+R  +G   L +   G  R +
Sbjct: 357 VRRLFDAVGFPVLRLVRVKVGPIGLGDQRQGSIRNL 392


>UniRef50_C7GZ55 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZ55_9FIRM
          Length = 250

 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 7/222 (3%)

Query: 3   QFIISENTMQKTSFR---NHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEA 58
           + I                  V   +      R  E Q     I  NKP   +   +DE 
Sbjct: 20  ELIKEGRVTVGGIPLLECGVNVDEDAVIAIDGRPIEIQKKTVYIAMNKPCGYVCTVSDEL 79

Query: 59  GRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           GR+T+ + +    + ++  GRLD+DSEGL++LTN+G L  +L  P ++  K Y V V G+
Sbjct: 80  GRRTVYDLLTDIDERLFTIGRLDKDSEGLILLTNDGDLAQKLLSPKRKIEKNYEVVVRGV 139

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTS-WLKITLYEG 175
           P  + ++ L  G+T++   +     + V        +   I E         L + + EG
Sbjct: 140 PGANDIKKLSGGITIDVEISQTKQNKPVKSIVKYHTKPAKIFEIGQKQGDMKLSMIIKEG 199

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           + RQ+R+M   +G   ++L R       L +L  GE+R +++
Sbjct: 200 KKRQIRKMFDVIGHEVIKLKRVKFAGIELGDLRPGEFRHLSE 241


>UniRef50_C8NZC3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZC3_ERYRH
          Length = 246

 Score =  211 bits (538), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 18/215 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++     K + +  +V                +     + NKP  ++    D+  R+
Sbjct: 32  KVKVNG---IKVTEQGLKVSTEDRVMVNGILINVEEKKVYYILNKPRGIVSSANDDKDRE 88

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           ++ + +P    V+  GRLDR++ G L+LTN+G     +T P     KIY V V G  + +
Sbjct: 89  SVVDLVPNDIRVFPVGRLDRETTGALILTNDGDFAYYMTHPKFDLSKIYRVSVRGRLSYE 148

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
              +L+ G+T+            V             +   +   +   ITL+EG+NRQ+
Sbjct: 149 VTNSLKEGITIEGVEYKGVEISRV-------------KYDAAKDKTQFSITLHEGKNRQI 195

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R++ AH G P L+L RY +G   +D L  G++RE+
Sbjct: 196 RKIFAHFGLPVLKLHRYQIGYLDIDELKIGQYREL 230


>UniRef50_C4V2S0 Pseudouridine synthase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2S0_9FIRM
          Length = 290

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 65/216 (30%), Positives = 104/216 (48%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +     +    +   +   T  +  N+    IL +KP   L    D+ GR+T
Sbjct: 28  RVTVDGLPVTALGGKYDAARHEIAVDGTPIR-RNERRFYILLHKPRGCLSTAYDDRGRRT 86

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P     +Y  GRLD D+EGLL++TN+GA+   L  P     K+Y  +V G  T+D
Sbjct: 87  VLDLLPHFPARLYPVGRLDADTEGLLIITNDGAMTQGLLHPRFEIDKVYRAEVTGNVTED 146

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L ALRNG+ L+DG T PA   ++                +    + ++  ++EGR RQV
Sbjct: 147 GLTALRNGILLDDGRTAPARLRVL---------------HREGERTVVETIIHEGRKRQV 191

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM A +G    RL R      +LD ++ G +R +T
Sbjct: 192 RRMFAAIGCRVQRLCRVRFAMLTLDGVSCGSFRHLT 227


>UniRef50_B1C6T1 Pseudouridine synthase n=2 Tax=Clostridiales RepID=B1C6T1_9FIRM
          Length = 238

 Score =  211 bits (537), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 55/216 (25%), Positives = 96/216 (44%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++   +++     +  K        +    +      + NKP  V+     + G +T
Sbjct: 30  KVTVNGEVVRELGTIINVEKDLVKV-YGKEVSLDTKKVYYMLNKPQGVISASKSKYGEET 88

Query: 63  LKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      ++  GRLD+D+ GL++LTN+G    +LT P     K Y   V+G     
Sbjct: 89  VVDLLGKKEHRLFPVGRLDKDTTGLIILTNDGDFAYKLTHPKYEKEKTYEALVKGKVDSK 148

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           +L+ L+ GV ++   T  A   LV               +     S ++ITL EGR RQV
Sbjct: 149 SLDKLKQGVVIDGKKTSRAKVRLV---------------KMIGVNSLVEITLIEGRKRQV 193

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++M   VG   ++L R      SL +L  GE+R++T
Sbjct: 194 KKMCEKVGHKVIKLNRTMENGLSLGDLEIGEYRKLT 229


>UniRef50_A3YG85 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=A3YG85_9GAMM
          Length = 242

 Score =  211 bits (537), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 98/174 (56%), Positives = 123/174 (70%), Gaps = 1/174 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
             +I+FNKP+ VL QFT +  + TL  FI     Y AGRLD DSEGLL+LT++GALQ  +
Sbjct: 2   PSIIVFNKPFQVLSQFTTDEEKATLSSFIDKANFYPAGRLDYDSEGLLLLTDHGALQHLI 61

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
             P  +  K Y VQVEG  T++A+E LR GV L DG T PA A++  +    WPR+PPIR
Sbjct: 62  ASPQHKMPKTYLVQVEGELTKEAVEQLRVGVELKDGLTKPAEAKIASD-FEPWPRHPPIR 120

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           ERK+IPTSWL++T+ EG+NRQVRRMTA VGFPTLRLIR  +G YSL ++  G W
Sbjct: 121 ERKNIPTSWLELTITEGKNRQVRRMTAAVGFPTLRLIRTQIGPYSLTDIELGHW 174


>UniRef50_C6AV89 Pseudouridine synthase n=17 Tax=Rhizobiaceae RepID=C6AV89_RHILS
          Length = 268

 Score =  211 bits (537), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 58/219 (26%), Positives = 92/219 (42%), Gaps = 22/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKR-FSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  +   T+   S     V    +S          +    ++ NKP  ++    D  GR 
Sbjct: 50  RVAVDGRTVSDASA---WVDLATASISIDGLVIAAEAKIYLMLNKPRGLVTTRHDPEGRP 106

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + +       +   GRLD+ SEGLL+ TN+      L  P     K Y+VQ++ I  
Sbjct: 107 TVYDCLRDFDIPHLSPVGRLDKASEGLLLFTNDTEFAQILLDPVTHVTKTYHVQIDRIMD 166

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            + + A+  G+  +                 L       R R+    SW+++ L EGRNR
Sbjct: 167 DEDIAAMTAGIRHDGE---------------LLTATAARRLRQGDRNSWIEVELDEGRNR 211

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           Q+RRM   +G   LRL+R A+G   L  L  G  R +T+
Sbjct: 212 QIRRMLEALGTECLRLVRVAIGGLELGELPKGAVRALTE 250


>UniRef50_D2R7V9 Pseudouridine synthase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R7V9_9PLAN
          Length = 811

 Score =  211 bits (537), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 18/214 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    + +   R   VK+  + R              + NKP  V+    D+AGR  
Sbjct: 59  RVDVDGKVVTELGTRVDPVKQ--TIRVDGEALRKPQRLYFVVNKPEGVVTTNYDQAGRTR 116

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +P  + V+A GRLDR SEGL+++TN+G    R+T P     K Y V+V G  +   
Sbjct: 117 VIDLVPTDERVFAVGRLDRASEGLIIVTNDGEFANRVTHPRYGVTKTYLVRVAGEASTAE 176

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L  LR G+ L+DG       ++               +R+   ++ + I L EG+NR++R
Sbjct: 177 LAKLRRGIHLSDGFCKVDAIQV---------------KRRHKQSTDMVIQLSEGKNREIR 221

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R+ A +G   L+L R A+G   L  L  G WR +
Sbjct: 222 RILARIGHKVLKLKRLAVGSLKLGELPLGAWRWL 255


>UniRef50_B2T6J8 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=B2T6J8_BURPP
          Length = 189

 Score =  210 bits (536), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 86/180 (47%), Positives = 116/180 (64%), Gaps = 4/180 (2%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
            ++  NKP+  + QF+    R +L +++ V  VY AGRLD DSEGLL+LT++GALQAR+ 
Sbjct: 2   HLLALNKPFGTICQFSPHETRASLADWVKVPDVYPAGRLDSDSEGLLLLTDDGALQARIA 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
           +P  +  K Y+ QVEG      L+ L  GV L D  T P  AE V+    LW R PPIR 
Sbjct: 62  EPRHKLVKRYWAQVEGAVDAATLKKLARGVDLGDYVTRPCRAEYVEPTDALWTRTPPIRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDY---SLDNLANGEWREVT 216
           R +IPT+W+++++ EG+NRQVRRMTA VGFPTLRL+R  +G     SL  L  GE  E++
Sbjct: 122 RAAIPTTWIELSITEGKNRQVRRMTAAVGFPTLRLVRVGIGALDIFSLG-LQPGESVELS 180


>UniRef50_C9LMF3 Ribosomal small subunit pseudouridine synthase A n=1 Tax=Dialister
           invisus DSM 15470 RepID=C9LMF3_9FIRM
          Length = 277

 Score =  210 bits (536), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 51/225 (22%), Positives = 91/225 (40%), Gaps = 16/225 (7%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   +    F    V                     + NKP  V+    D   +KT+
Sbjct: 44  VQVNGEKITDPGFM---VNENDEIIFAGEPVPYFRYEYYMLNKPAGVITATED-RYQKTV 99

Query: 64  KEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            +F   +    +   GRLD+D+ GLL++TN+G    RL  P K   K YY +++G   + 
Sbjct: 100 LDFFGERRRKDLSPVGRLDKDTVGLLLVTNDGGFHHRLLSPKKHIDKEYYARIDGRVDEA 159

Query: 121 ALEALRNGVTLNDGPT-LPAGAEL-------VDEPAWLWPRNPPIRERKSIPTSWLKITL 172
             E    G+ +++  T LPA   +       ++        +   +       S +++ +
Sbjct: 160 DREKFEKGIYVDEIFTALPAKLMIDGYRENALESDFMDLANSRAPKSALENGVSEIRVVV 219

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            EG+  Q++RM   +G   + L R  +G   LD  L  G +R +T
Sbjct: 220 QEGKFHQIKRMFHALGKEVIYLKRIRIGSVVLDPTLEEGTYRRLT 264


>UniRef50_B9E1X9 Pseudouridine synthase n=39 Tax=Clostridium RepID=B9E1X9_CLOK1
          Length = 245

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 59/199 (29%), Positives = 97/199 (48%), Gaps = 17/199 (8%)

Query: 21  VKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRKTLKEFIP-VQGVYAAGRL 78
                      +  + +     IL NKP   +    D+ GRKTL + +   + VY  GRL
Sbjct: 50  DDERDEILVDNKIIKKENKKVYILLNKPRGYISSVKDDRGRKTLLDIVKVNERVYPIGRL 109

Query: 79  DRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLP 138
           D ++ G ++LTN+G +   +  PG    KIY   ++GIP+ + ++   NG+ +    T  
Sbjct: 110 DYNTSGAIILTNDGEVYNNIAHPGSNKSKIYIAAIKGIPSSEEIKRFENGIDIGGYITAK 169

Query: 139 AGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYA 198
           A  + +                 +  +S +KI ++EG+NRQVR+M   +G P + L+R A
Sbjct: 170 AKFDFISS---------------NKESSKVKIEIHEGKNRQVRKMCDAIGHPVITLMRIA 214

Query: 199 MGDYSLDNLANGEWREVTD 217
           +GD  L NL  G WR +T+
Sbjct: 215 IGDIKLGNLKEGAWRYLTE 233


>UniRef50_B9XS61 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XS61_9BACT
          Length = 235

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 56/217 (25%), Positives = 96/217 (44%), Gaps = 19/217 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++ +T+++   +   +    S          +    +  NKP   +    D+  RK 
Sbjct: 27  RVSVNGDTVRELGTKVDPI--HDSIALDGAPLRLKRKLYVALNKPRGYVCSRKDDRKRKV 84

Query: 63  LKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +P +   +Y+ GRLD DSEGL+ LTN+G     LT P  R  K Y   VEG   Q+
Sbjct: 85  IGDLLPAEWDNLYSVGRLDSDSEGLIFLTNDGEFSLHLTHPRYRVLKKYLATVEGRVEQE 144

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+  ++G+           A  +                    TS +++ L EG+NR++
Sbjct: 145 MLQRFKHGIVHEGEKLKVDRARTLS---------------VQNSTSLVELELTEGKNREI 189

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+    G    RL+R  +G   L  L +G+WR +T+
Sbjct: 190 RRLFESQGLTVSRLVRMQIGKIKLGELRSGKWRMLTE 226


>UniRef50_A1K7C2 Pseudouridine synthase n=1 Tax=Azoarcus sp. BH72 RepID=A1K7C2_AZOSB
          Length = 356

 Score =  209 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 58/227 (25%), Positives = 96/227 (42%), Gaps = 25/227 (11%)

Query: 1   MRQFIISENTMQK--TSFRNHQVKRFSSQRSTRRKPE----NQPTRVILFNKPYDVLPQF 54
           + + +++         +    ++      +   +        +  RV++++KP   +   
Sbjct: 108 IEELVVAGRISVNGLPASLGQKIGPGDRVKLNGKLIPLRFSQRSPRVLVYHKPEGEIVSR 167

Query: 55  TDEAGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D  GR T+ E +P        A GRLD ++ GLL+ TN+G L  RL  P     + Y V
Sbjct: 168 DDPEGRPTVFERLPLLRKGRWLAVGRLDFNTSGLLLFTNDGDLANRLMHPRYELTREYAV 227

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           ++ G  T++  ++L +G+ L DGP                     +         W ++T
Sbjct: 228 RLLGQLTEEQGQSLVDGIQLEDGPARFLSL---------------VDAGGEGVNHWYRVT 272

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           L EGRNR+VRRM   VG    RL+R   G   L   L  G W E+ +
Sbjct: 273 LAEGRNREVRRMFEAVGLTVSRLMRVRYGPVELPARLKRGMWMELPE 319


>UniRef50_A6GNL7 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=A6GNL7_9BURK
          Length = 458

 Score =  209 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 25/225 (11%)

Query: 1   MRQFIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQ----PTRVILFNKPYDVLPQF 54
           M + I++       + +    +V      R   +  + +    P RV++++KP   +   
Sbjct: 86  MEELIVAGRVSVNAEPAHLGQRVLPTDQVRVNGKLIQRKNKSKPPRVLIYHKPAGEIVSM 145

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D  GR T+ + +P        A GRLD ++EGLL+ T++G L  RL  P     + Y V
Sbjct: 146 DDPQGRTTVFQKLPKISNGKWIAVGRLDFNTEGLLLFTSSGELANRLMHPRYEVQREYAV 205

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           ++ G  +++  + L  G+ L DGP      +                        W K+ 
Sbjct: 206 RILGELSEEQRQQLLTGIQLEDGPAKFLYVD---------------AAGGEGANRWYKVG 250

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           L EGRNR+VRRM         RLIR   GD  +   L  G   E+
Sbjct: 251 LKEGRNREVRRMFEACNLTVSRLIRTRFGDIMMPSTLKRGRHMEM 295


>UniRef50_Q5ZXB8 Pseudouridine synthase n=2 Tax=Legionella pneumophila
           RepID=Q5ZXB8_LEGPH
          Length = 222

 Score =  209 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 101/178 (56%), Positives = 128/178 (71%), Gaps = 1/178 (0%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARL 98
            ++ILFNKPY +L QFT E   +TL  FI + G YAAGRLD+ SEGLL+LT++G LQ RL
Sbjct: 24  PQLILFNKPYGILTQFTGELPEQTLSAFIKLPGFYAAGRLDKQSEGLLILTDDGKLQHRL 83

Query: 99  TQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
           T P     K Y+VQVEG+PT   L+ LR G+ + D   LPA A L+ EP  +WPR PPIR
Sbjct: 84  THPKFEKKKHYWVQVEGVPTDKDLQPLRKGLVIKDITFLPAEARLISEP-KIWPRIPPIR 142

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ERK IPT+WL+I L EG+N Q+R+MTA +GFPTLRLIRY +GD+ LD L  GE++ + 
Sbjct: 143 ERKHIPTTWLEIILREGKNHQIRKMTAAIGFPTLRLIRYQIGDWHLDQLQPGEYKLIN 200


>UniRef50_C4ZJR2 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=C4ZJR2_THASP
          Length = 379

 Score =  209 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 58/223 (26%), Positives = 98/223 (43%), Gaps = 27/223 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEA 58
           +  ++       +    ++      +   +        +  RV++++KP   +    D  
Sbjct: 142 RISVNGL----PASLGQKIGPGDRVKVNGKLVPLRFTQRSPRVLIYHKPEGEIVSRDDPE 197

Query: 59  GRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
           GR T+ E +P        A GRLD ++ GLL+ TN+G L  +L  P     + Y V++ G
Sbjct: 198 GRPTVFERLPILRKGRWLAVGRLDFNTSGLLLFTNDGDLANKLMHPRYELEREYAVRILG 257

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             T++ +++L +G+ L DG   PA   L+ +                    W ++T+ EG
Sbjct: 258 ELTEEQVKSLTDGIQLEDG---PAKFNLLRDEGG------------EGANHWYRVTISEG 302

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           RNR+VRRM   VG    RL+R   G   L   L  G W E+ +
Sbjct: 303 RNREVRRMFEAVGLTVSRLMRVRYGSVELPARLKRGMWMEMPE 345


>UniRef50_B0VG32 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VG32_9BACT
          Length = 279

 Score =  209 bits (533), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 96/216 (44%), Gaps = 20/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++ N +Q  S +    K         +  +  +    ++ NKP   +    DE GRK
Sbjct: 65  RIAVNGNLVQDLSRQIIPGK--DKVTLDGKPIQPAKEKFYLILNKPRGYVVSQNDELGRK 122

Query: 62  TLKEFIPVQG--VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+   +P +G  +  AGRLD++SEGLL  TN+ AL   LT P  +  K+Y V +      
Sbjct: 123 TVYSLLPPKGKQLAYAGRLDKESEGLLFFTNDTALINLLTHPKNKVEKVYRVDINRPLNN 182

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L  LR GV +  G TLPAG                  + K+     LKI + EGR RQ
Sbjct: 183 MELNMLRKGVEIEGGKTLPAGI---------------FVKSKNANGMTLKIVITEGRKRQ 227

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +R+M   VG     L R   G   L +L  G WR +
Sbjct: 228 IRQMIEAVGAKVTYLKRLQFGPLKLKDLPVGRWRLL 263


>UniRef50_A8SLU4 Pseudouridine synthase n=1 Tax=Parvimonas micra ATCC 33270
           RepID=A8SLU4_9FIRM
          Length = 230

 Score =  209 bits (533), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 58/216 (26%), Positives = 96/216 (44%), Gaps = 23/216 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  ++     K + +   +          +K + +   +  L NKP         +   K
Sbjct: 26  KVFVNG----KLATKGIDISENDEVLVEGKKIKLEEAKKYYLLNKPIGYSSTAKAQFQEK 81

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + + I   + +Y  GRLD+DS GLL+LTN+G L  RLT P     K Y V+V+    + 
Sbjct: 82  IVLDLIDSKERIYPVGRLDKDSFGLLLLTNDGDLAFRLTHPSHNVEKEYIVKVDKTLKES 141

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+ L +G+ L    T  A  E++D                   ++ +K+ L EGRNRQ+
Sbjct: 142 DLKKLSSGIMLEGKITRKARFEMLDF-----------------KSNIVKVFLKEGRNRQI 184

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R+M   + +  + L R A G   L  L  G +RE++
Sbjct: 185 RKMFKTLDYNVISLERIAFGKIKLGKLKVGNYRELS 220


>UniRef50_Q47QM5 Pseudouridine synthase n=3 Tax=Actinomycetales RepID=Q47QM5_THEFY
          Length = 375

 Score =  209 bits (533), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 64/220 (29%), Positives = 98/220 (44%), Gaps = 23/220 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTR-RKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  +    +++   R    K     R    R   +Q  R    NKP  V+    D  GR 
Sbjct: 160 RVSVDGQIVRRFGARVDPEKS--EIRVDGMRVVTSQNLRYYALNKPRGVVSTMFDPEGRP 217

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ ++        + ++  GRLD D+EGL++LTN+G L  RLT P  +  K Y  +V G 
Sbjct: 218 TIGDYAAQIGPIEERLFHVGRLDTDTEGLILLTNDGELANRLTHPRYKVTKTYLAKVPGP 277

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
             +D +  +R GV L+DG        ++D                  P + ++I L+EGR
Sbjct: 278 VPRDVIRQIRKGVELDDGFVKVDSFRVIDNIE---------------PKALVEIRLHEGR 322

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VRR+   VG P   L R  +G   L+NL +G  R +T
Sbjct: 323 KHIVRRLMKAVGHPVSDLARTQIGPVGLNNLKSGTIRALT 362


>UniRef50_D0MIA1 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MIA1_RHOM4
          Length = 268

 Score =  209 bits (533), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 94/221 (42%), Gaps = 27/221 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGRK 61
           Q  ++    Q       +V           +   Q     IL NKP+D +    DE GR+
Sbjct: 36  QVRVNGQVAQ----LGMRVGPDDIVEVNGVRVVPQTQALYILMNKPHDTITTCDDERGRR 91

Query: 62  TLKEFIPVQ-----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ + I +      G++  GRLDR++ G+L+LTN+G L  RL  P  R  KIY  +    
Sbjct: 92  TVLDLINLPPEQKNGLFPVGRLDRNTTGVLLLTNDGELANRLMHPRYRVEKIYVARTARP 151

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
              +  E LR GV L DGP       +                        + + +YEGR
Sbjct: 152 VKPEEAEQLRRGVQLEDGPARAVQVAV-----------------NPADPHEIALMIYEGR 194

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           NRQVRRM   +G   ++L R      +   +  G+WR +TD
Sbjct: 195 NRQVRRMLEAIGHEVVQLKRTHYAGLTTKGVRPGKWRRLTD 235


>UniRef50_B2V6W2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B2V6W2_SULSY
          Length = 244

 Score =  209 bits (532), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 58/222 (26%), Positives = 96/222 (43%), Gaps = 26/222 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             +++  ++  S+    +K          +   +     + NKP   +    DE    T+
Sbjct: 27  VKVNDEIVKDPSYHIDPMK--DKVELEDEEILYKENHYFMLNKPAGYITATEDEE-YPTV 83

Query: 64  KEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            +          ++  GRLD D+EGLL+LT +G    RL+ P     K YY  VEG  + 
Sbjct: 84  LDLFSDLPIASKLFPVGRLDIDTEGLLILTTDGQFGHRLSHPKWNIEKEYYAIVEGDISN 143

Query: 120 -DALEALRNGVTL--NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            D  E+   G+ L      T P   ++++                S   S + ITL EG+
Sbjct: 144 IDFSESENKGIYLKKEKYQTKPFKVKVLN---------------TSKDKSEILITLTEGK 188

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
              V+R+   +G+P L L R  +G+  LD +L  GE+RE+T+
Sbjct: 189 YHIVKRIMQELGYPVLYLKRIRIGNLKLDEDLLPGEFRELTE 230


>UniRef50_Q1LLR3 Pseudouridine synthase n=15 Tax=Proteobacteria RepID=Q1LLR3_RALME
          Length = 631

 Score =  209 bits (532), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 58/225 (25%), Positives = 90/225 (40%), Gaps = 25/225 (11%)

Query: 1   MRQFIISENTMQK--TSFRNHQVKRFSSQRSTRRKPENQ----PTRVILFNKPYDVLPQF 54
           M + I+          +    ++      R   +    +    P RV+L++KP   +   
Sbjct: 252 MEELILQGRVSVNGLPAHIGQRILPTDQVRVNGKLIHRKVTTKPPRVLLYHKPSGEIVSQ 311

Query: 55  TDEAGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
           +D  GR T+ + +P        A GRLD ++EGLL+ T +G +  R   P     + Y V
Sbjct: 312 SDPEGRPTVFDSLPRIKNGKWVAVGRLDFNTEGLLIFTTSGDIANRFMHPRYGVEREYAV 371

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +  G   +   + L +G+ L+DG                                W  + 
Sbjct: 372 RTLGELAEADRQRLLHGIQLDDGEANFLRI---------------ADGGGEGVNQWYHVA 416

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           L EGRNR+VRRM   VG    RLIR   G + L   L  G W+E+
Sbjct: 417 LTEGRNREVRRMFEAVGLTVSRLIRTRYGQFLLPRGLKRGRWQEL 461


>UniRef50_B1M661 Pseudouridine synthase n=2 Tax=Alphaproteobacteria
           RepID=B1M661_METRJ
          Length = 601

 Score =  209 bits (532), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++  T+   +     V             P  + +R+ +F+KP  V+    D  GR+
Sbjct: 111 RVSVNGETLTSPARN---VTENDRILIDGEPMPSRERSRLWIFHKPRGVVTTARDPEGRQ 167

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V A GRLD ++EGLL+LTN+G L   +  P     + Y V+  G   Q
Sbjct: 168 TVFDVLPEDLPRVVAVGRLDINTEGLLLLTNDGGLAKVIAHPDTGWLRRYRVRAHGDTDQ 227

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L  GVT++     P  A L               +R      WL + L EG+NR+
Sbjct: 228 AQLDRLAKGVTIDGMEYGPVEATL---------------DRVQGDNVWLTLGLREGKNRE 272

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+R+  H+G    RLIR + G + L +L  G   EV
Sbjct: 273 VKRILEHLGLSVNRLIRLSFGPFQLGDLEVGLVEEV 308


>UniRef50_Q1J642 Pseudouridine synthase n=51 Tax=Streptococcus RepID=Q1J642_STRPF
          Length = 244

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 65/220 (29%), Positives = 95/220 (43%), Gaps = 21/220 (9%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +   +++           + K              +     L NKP   +    D   + 
Sbjct: 26  KAIFVNQKVETSAKAHIDEYK--DLVTYQGTPLVYESFVYYLLNKPSGYVSATQD-RQQA 82

Query: 62  TLKEFI----PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ E +      + V+  GRLD+D+ GLL+LTNNG L   L  P K   K Y  +V GI 
Sbjct: 83  TVMELLDDTARQKTVFPVGRLDKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIM 142

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T+   +    G++L D   LPA  E++                    TS +KIT+ EG+ 
Sbjct: 143 TEADKDYFARGISLKDHQCLPAHLEVLASDL-------------QQQTSLVKITIQEGKF 189

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            QV+RM A  G   L L R +MG   LD +LA GE+R +T
Sbjct: 190 HQVKRMVAACGKEVLDLQRLSMGPLKLDPSLAEGEFRRLT 229


>UniRef50_C9RK28 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RK28_FIBSS
          Length = 243

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 21/220 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRF-SSQRSTRRK---PENQPTRVILFNKPYDVLPQFTDEA 58
           +  ++  T+       HQV           +    P N+ T+VI+F+KP   +    D  
Sbjct: 26  RVQVNGETISDL---GHQVDETKDQVTVDGKLLKLPTNKKTKVIMFHKPAGCVCTKDDPQ 82

Query: 59  GRKTLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           GR+T+ +++P         GRLD  S GLL+ T++G L  RLT P     + YYV     
Sbjct: 83  GRRTVYDYLPPGYHNFKYVGRLDLQSRGLLLFTDDGELLYRLTHPSFEVPRSYYVWTTRP 142

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            ++ A + L +GV + D     A  E+                         ++ L EG+
Sbjct: 143 LSESAAQRLVDGVDIRDPEDPDAQEEIAFATDVYLENGFA------------ELVLIEGK 190

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           NR++RRM   +G+    L R +     L +L  GE+RE+T
Sbjct: 191 NREIRRMMRAIGYEIRDLKRVSYCQIQLGDLPAGEFRELT 230


>UniRef50_C3X1E1 Pseudouridine synthase n=2 Tax=Oxalobacter formigenes
           RepID=C3X1E1_OXAFO
          Length = 510

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 57/227 (25%), Positives = 92/227 (40%), Gaps = 25/227 (11%)

Query: 1   MRQFIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQP----TRVILFNKPYDVLPQF 54
           M + I++       + +    ++      R   +  + +      RV+ ++KP   +   
Sbjct: 191 MEELIVAGRVSVNGEPAHIGQRILPTDQVRLNGKLIQRKIAKSLPRVLTYHKPAGEIVSR 250

Query: 55  TDEAGRKTLKE---FIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D   R ++ +    +      A GRLD ++EGLL+ TN+G L  RL  P     + Y V
Sbjct: 251 DDPEKRPSVFDRLPLLKNSKWLAVGRLDFNTEGLLLFTNSGDLANRLMHPRYNIEREYAV 310

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +  G   +   + L  GV L DG    +                 +         W ++T
Sbjct: 311 RTLGELEEGMRQKLLAGVDLGDGIGQFSKI---------------VDGGGEGVNKWYRVT 355

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           + EGRNR+VRRM   VG    RLIR   G   L  +L  G W E+ +
Sbjct: 356 IGEGRNREVRRMFEAVGLTVSRLIRTRYGAVVLSQSLKRGRWDELEE 402


>UniRef50_C6X4T2 Pseudouridine synthase n=2 Tax=Flavobacteriaceae RepID=C6X4T2_FLAB3
          Length = 371

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 51/217 (23%), Positives = 92/217 (42%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +     +QV++        +    +    +L NKP   +    DE  RKT+
Sbjct: 165 VQVNGAVVTE---MGYQVQKTDKVIFDGQGITPEKPVYVLLNKPKGYISTTKDEKARKTV 221

Query: 64  KEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + +       V+  GRLDR + G+++LTN+G +  +LT P     KIY+V ++    + 
Sbjct: 222 MDLVANASPYRVFPVGRLDRSTTGVILLTNDGHMTKKLTHPSFNMKKIYHVTLDRKLDRA 281

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L A+  GV L +G         +                +  P + + I ++ G NR V
Sbjct: 282 DLNAIAEGVRLEEGVAEVDSISYI----------------EGKPKNEVGIEIHIGWNRVV 325

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RR+   +G+    L R      +  N+  G WR +T+
Sbjct: 326 RRIFQRLGYEVEALDRVMFAGLTKKNIKRGHWRILTE 362


>UniRef50_Q3AVD5 Pseudouridine synthase n=3 Tax=Cyanobacteria RepID=Q3AVD5_SYNS9
          Length = 247

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 72/218 (33%), Positives = 99/218 (45%), Gaps = 24/218 (11%)

Query: 3   QFIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +  +          +  N Q+               Q  RV L NKP  V+    D  GR
Sbjct: 29  RVTVDGRVASLGDQADPNSQLIEVDGVPL----ISVQEPRVFLLNKPVGVICSCRDPQGR 84

Query: 61  KTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            T+ + +P Q   G++  GRLD DS G L+LT+ G L  RLT P     K Y V V GIP
Sbjct: 85  ATVLDCLPHQERSGLHPVGRLDADSRGALLLTDQGELTLRLTHPRYNHAKTYRVLVRGIP 144

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           +  AL   R+G+ L+   T PA    +               R    +S L++ L EGRN
Sbjct: 145 SSQALRRWRDGLLLDGRLTRPARVHCL---------------RSRGASSLLEVELKEGRN 189

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RQ+RR+   +G P + L R A+    LD+LA G WR +
Sbjct: 190 RQIRRVAELLGHPVIDLQRVAIDGIRLDDLAEGCWRRL 227


>UniRef50_UPI0001BC42E2 ribosomal small subunit pseudouridine synthase A n=3
           Tax=Fusobacterium RepID=UPI0001BC42E2
          Length = 235

 Score =  207 bits (529), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 26/219 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           R+  ++   +        + K         +K   Q  R  + +K    +    D     
Sbjct: 25  RKIRVNGLFITSPKENIEEEK--DEVYYGEKKLSYQEFRYYILHKKAGYVTALEDSRE-A 81

Query: 62  TLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + +P     + +   GRLD+D+EGLL+ TN+G L  RL  P     K Y+  +E   
Sbjct: 82  TVMDLLPEWVIKKDLAPVGRLDKDTEGLLLFTNDGKLNHRLLSPKSHVDKTYHASLECDI 141

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T++ALE LR GV + +  TLPA AE +++                     + +T+ EG+ 
Sbjct: 142 TEEALEKLREGVMIGEYKTLPAKAEKLED-------------------RKIALTIREGKF 182

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            QV++M   VG   + L R + G   L +L  GE +EV+
Sbjct: 183 HQVKKMLEAVGNKVIYLKRISFGKLVLGDLELGEVKEVS 221


>UniRef50_A3ESK0 Pseudouridine synthase n=4 Tax=Bacteria RepID=A3ESK0_9BACT
          Length = 616

 Score =  207 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 68/216 (31%), Positives = 101/216 (46%), Gaps = 20/216 (9%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRKT 62
             ++   +     + H            +    +P   + LF KP  ++    D   + T
Sbjct: 44  VKVNGIVVTVPGTKVHP--ETDRVTVDGKTVPVEPEPFLFLFYKPKGIVSTLHDPDEKTT 101

Query: 63  LKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           LK+F P    +   GRLD  SEG+L+LTNNG L  R+  P     + Y V+V+G+   + 
Sbjct: 102 LKDFFPQINPLIHVGRLDIQSEGVLLLTNNGDLAQRILHPRYEIPRTYLVKVQGVVKPEH 161

Query: 122 LEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           L+ LR+G V L+  P  P   E               +ER +   SW +ITL EGRNR+V
Sbjct: 162 LDRLRSGKVRLDGRPVQPLELE---------------QERLTETNSWYRITLTEGRNREV 206

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RR+   + +  L+L R A G+  L  L  GE+R VT
Sbjct: 207 RRLFDALHYFVLKLTRIAFGNLDLAGLEPGEYRLVT 242


>UniRef50_Q7MMX9 Pseudouridine synthase n=43 Tax=Vibrionaceae RepID=Q7MMX9_VIBVY
          Length = 347

 Score =  207 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 52/216 (24%), Positives = 89/216 (41%), Gaps = 24/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I+     K      +V          +     +    I  NKP  +           
Sbjct: 32  RVTING----KQPEMGTKVLPGDDVCVDGKPVAAKEKPVYIALNKPTGITCTTERNIPGN 87

Query: 62  TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +      + ++  GRLD+ S+GL+ LTN+G +  ++ + G    K Y V+V+   T + 
Sbjct: 88  IVDFIGHKKRIFPIGRLDKPSDGLIFLTNDGDIVNKILRAGNHHEKEYVVRVDKPITPEF 147

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           ++A+ +GV + D  TLP                              +I L +G NRQ+R
Sbjct: 148 IKAMSSGVNILDTVTLPCKVT-------------------QETKFSFRIVLTQGLNRQIR 188

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RM   +G+   +L R  + + SLD + NG+WR +TD
Sbjct: 189 RMCEALGYEVFKLRRVRIMNISLDGIPNGKWRYLTD 224


>UniRef50_Q042N1 Pseudouridine synthase n=3 Tax=Lactobacillus gasseri
           RepID=Q042N1_LACGA
          Length = 245

 Score =  207 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 60/220 (27%), Positives = 97/220 (44%), Gaps = 23/220 (10%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +   ++   +        QVK          K   Q     L NKP  V+    D   ++
Sbjct: 37  KVVTVNGELVTIPK---QQVKETDLVAVDGNKIAYQQYHYFLLNKPKGVISATED-RSQQ 92

Query: 62  TLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+   +      QG+   GRLD+D+ GLL+LTN+GAL   L  P K   K+Y  ++ G+P
Sbjct: 93  TVISLLKTKDRYQGIAPVGRLDKDTTGLLLLTNDGALAHELLAPNKHVAKVYRAKIAGVP 152

Query: 118 TQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
             +  +    G+ L DG    PA  +++ +              +    S ++I + EG+
Sbjct: 153 DPETAKKFAQGLILGDGTKLKPAKLKILKQD-------------QDNNLSQIEIQIQEGK 199

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
             Q++RM   VG   L L R +MG   L  +L  GE++E+
Sbjct: 200 YHQIKRMFGAVGMKVLELDRVSMGKLHLPADLKRGEYKEI 239


>UniRef50_Q140U9 Pseudouridine synthase n=80 Tax=Proteobacteria RepID=Q140U9_BURXL
          Length = 633

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 63/227 (27%), Positives = 94/227 (41%), Gaps = 25/227 (11%)

Query: 1   MRQFIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQ----PTRVILFNKPYDVLPQF 54
           M + I++       + +    ++      R   +  + +    P RV+L++KP   +   
Sbjct: 234 MEELIVAGRVSVNGEPAHIGQRIMPTDQVRINGKPVKRKLASKPPRVLLYHKPTGEIVSH 293

Query: 55  TDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D  GR ++ + +P        A GRLD ++EGLL+LT +G L  R   P     + Y V
Sbjct: 294 ADPEGRPSVFDKLPPMKTAKWLAVGRLDFNTEGLLMLTTSGDLANRFMHPRYSVEREYAV 353

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +V G   +   + L +GV L+DGP                               W  + 
Sbjct: 354 RVVGELAEGMRQKLLHGVELDDGPANFLRIR---------------DGGGEGTNHWYHVA 398

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVTD 217
           L EGRNR+VRRM    G    RLIR   G  SL   L  G W E+ D
Sbjct: 399 LAEGRNREVRRMFEAAGLMVSRLIRTRHGPISLPKGLKRGRWEELED 445


>UniRef50_A4QE19 Pseudouridine synthase n=13 Tax=Corynebacterineae
           RepID=A4QE19_CORGB
          Length = 320

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 62/220 (28%), Positives = 95/220 (43%), Gaps = 23/220 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  +++  +     R +        R    +   N+     + NKP  +    +DE GR 
Sbjct: 105 RVEVNDRIVTTQGVRVNP--NNDVIRVDGVRIHINEDLEYFVLNKPRGMHSTMSDELGRP 162

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
            + + +       Q ++  GRLD D+EGLL+LTN+G L  RL  P     K Y   V G 
Sbjct: 163 CVGDLVSEKTASGQRLFHVGRLDADTEGLLLLTNDGELANRLMHPKYEVSKTYLATVRGE 222

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            T   + ALR+GV L DGP     A+++D                    S L+I ++EGR
Sbjct: 223 ATNKLVSALRDGVELEDGPAKADFAQIID---------------VFQGKSLLRIEIHEGR 267

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VRR+   +GFP  RL+R  +    L +   G  R + 
Sbjct: 268 KHIVRRLFDELGFPVERLVRTKLHTVQLGDQKPGSLRALN 307


>UniRef50_Q2LSY4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LSY4_SYNAS
          Length = 251

 Score =  207 bits (527), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 93/216 (43%), Gaps = 20/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +++   +          R   +     +    ++ NKP   +   +D   R 
Sbjct: 28  RVSVNSEIVRELGSK--ADIERDEIRVDGKLICAEETKVYVMLNKPRGYVTALSDPQKRP 85

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            +   +P     ++  GRLD DSEGLL+LTN+G    R+  P  R  K Y V++ G    
Sbjct: 86  LVIHLLPELGVRLFPVGRLDYDSEGLLLLTNDGGFAQRVQHPRYRISKTYRVKISGRLNA 145

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
                L+ G+ L DG   P    L               E  +  +SWL + + EGRNR 
Sbjct: 146 AEFNRLQKGLELEDGKFAPDEVAL---------------EEINPKSSWLTMKISEGRNRV 190

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +RR    +G   LRLIR A+ D  L NL  G++R +
Sbjct: 191 IRRAFEQLGHEVLRLIRTAVADLHLGNLREGDYRLL 226


>UniRef50_C1XV14 Pseudouridine synthase n=2 Tax=Meiothermus RepID=C1XV14_9DEIN
          Length = 369

 Score =  207 bits (527), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 63/217 (29%), Positives = 95/217 (43%), Gaps = 27/217 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I++      +     V           +    +   VI  +KP  V    +D    +
Sbjct: 26  RVTINDQI----AGIGSSVSESDVVCLDGERVRLPEKKVVIALHKPVGVTTTKSDPHAER 81

Query: 62  TLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE-GIPTQ 119
           T+ + +P   G++  GRLD+DSEGLL+LTN+G L  +LT P     K+Y    + G  ++
Sbjct: 82  TVYQLVPDVPGLHPVGRLDKDSEGLLLLTNDGDLTLKLTHPRYGVRKVYRAWCKHGRVSE 141

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
                L  GV L+DG      AE   E A                    +I + EG+ R+
Sbjct: 142 ADCRRLVEGVALDDGLAQALEAEPTQEGA--------------------RIVMAEGKKRE 181

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM   +G+P  RL+R  +G   L  L  GEWR +T
Sbjct: 182 VRRMLGRLGYPVTRLVRLQVGPIKLGKLNPGEWRYLT 218


>UniRef50_B1XJP9 Pseudouridine synthase n=3 Tax=Chroococcales RepID=B1XJP9_SYNP2
          Length = 259

 Score =  207 bits (527), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 62/222 (27%), Positives = 95/222 (42%), Gaps = 26/222 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP---ENQPTRVILFNKPYDVLPQFTDEAG 59
           +  ++   +Q     +             +     E       L +KP  V+    D  G
Sbjct: 28  RVTLNGKPVQ---LGDQADPEGDRLCVDGKPLKATERPRHYYYLIHKPKGVVSTCADPKG 84

Query: 60  RKTLKEFIPVQ-----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
           R T+ + +P       G++  GRLD  S G L+LTN+G     LT P     K Y V ++
Sbjct: 85  RSTVLDLLPPPLRQGKGIHPIGRLDAQSTGALLLTNDGNFTLALTHPRYHIPKTYRVWLK 144

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
           G   +  L+  R GV L D  TLP    L               +  +   + + I L E
Sbjct: 145 GKVPEHVLDQWRQGVMLGDRRTLPTQIHL---------------KTITQDKTCIDIMLTE 189

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           GRNRQ+RR+   +GFP ++L R A+G+  L +L  G+ R +T
Sbjct: 190 GRNRQIRRVAEQLGFPVVKLHRLAIGNLHLGDLQRGQARPLT 231


>UniRef50_A9KPL1 Pseudouridine synthase n=63 Tax=Bacteria RepID=A9KPL1_CLOPH
          Length = 477

 Score =  206 bits (526), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 54/216 (25%), Positives = 89/216 (41%), Gaps = 24/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRK 61
           +  I        +    +V         +++   +    +I F+KP  ++          
Sbjct: 44  EVTIDGEV----AVMGSKVLPGQKVVLGKKEVSREEKMVLIAFHKPKGIVCTTEKREPDN 99

Query: 62  TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +      Q +Y  GRLD+DSEGL+ LTNNG +  ++ + G    K Y V V    T   
Sbjct: 100 IIDYIKYSQRIYPIGRLDKDSEGLIFLTNNGDIVNKILRAGNHHEKEYIVTVNKPITAAF 159

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           L+ +  GV + D  T P   E +D+                      +I L +G NRQ+R
Sbjct: 160 LKGMAGGVPILDTVTKPCTLEAIDK-------------------VTFRIILTQGLNRQIR 200

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RM  H  +   +L+R  + + +L  L  G +R +TD
Sbjct: 201 RMCEHFDYKVTKLVRIRIMNVNLGRLKVGGYRNLTD 236


>UniRef50_C7I043 Pseudouridine synthase n=4 Tax=Proteobacteria RepID=C7I043_THIIN
          Length = 562

 Score =  206 bits (525), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 59/221 (26%), Positives = 88/221 (39%), Gaps = 27/221 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE----NQPTRVILFNKPYDVLPQFTDEA 58
           +  ++       +    ++      R   +  +        RV+ ++KP   +  F D  
Sbjct: 197 RVSVNGE----PAHLGQRILPTDQIRVNGKIIKRRLRPAQARVLAYHKPTGEVVSFKDPE 252

Query: 59  GRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
           GR T+ + +P        A GRLD ++EGLL+ T +G L  RL  P     + Y V+V G
Sbjct: 253 GRPTVFQHLPKLQGAKWTAVGRLDINTEGLLLFTTSGDLANRLMHPSYGAEREYAVRVLG 312

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
                A + L  GV L DGP      E                        W ++ + EG
Sbjct: 313 ELDAAARDELLEGVQLGDGPARFLSLE---------------EAGGEGANRWWRVVISEG 357

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           RNR+VRRM   VG    RLIR       L   L  G++ E+
Sbjct: 358 RNREVRRMFEAVGLTVSRLIRVRYASVVLPAGLRRGDFVEL 398


>UniRef50_A1UU09 Pseudouridine synthase n=4 Tax=Bartonella RepID=A1UU09_BARBK
          Length = 499

 Score =  206 bits (525), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 55/216 (25%), Positives = 94/216 (43%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +         V                + TR+ L++KP  ++    D  GR 
Sbjct: 70  RIAVNGTVVTTP---VLNVIPSDHITVDEIPIPPIERTRLWLYHKPSGLVTTNRDPEGRP 126

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P +   V + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G   Q
Sbjct: 127 TVFDNLPKEMPRVVSVGRLDINTEGLLLLTNDGGLARVLELPLTGWVRKYRVRAHGKIKQ 186

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L+NG+ ++        A +               +R+     WL + L EG+NR+
Sbjct: 187 SELDKLKNGIAIDGIFYGSIDASI---------------DREQGSNVWLSVALREGKNRE 231

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ++     +G    RLIR + G + L +L  G  RE+
Sbjct: 232 IKNFLGALGLSVNRLIRVSYGPFQLSDLEEGAVREL 267


>UniRef50_A9ITY6 Pseudouridine synthase n=6 Tax=Betaproteobacteria
           RepID=A9ITY6_BORPD
          Length = 588

 Score =  206 bits (525), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 60/221 (27%), Positives = 91/221 (41%), Gaps = 27/221 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEA 58
           +  ++       +    +V      R   +        +P RVIL++KP   +    D  
Sbjct: 148 RVSVNGE----PAHIGQRVAPSDQVRVNGKPVARPNTKKPPRVILYHKPAGEIVSHDDPG 203

Query: 59  GRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
           GR ++   +P        + GRLD ++EGLL+ T +G +  R+  P   T + Y V+V G
Sbjct: 204 GRASVFARLPKLRTGKWLSVGRLDLNTEGLLIFTTSGDMANRIMHPRYGTEREYAVRVLG 263

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
                  ++L  G+ L DG       + +                      W ++TL EG
Sbjct: 264 EMDDATRKSLVEGIELEDGQAAFGALDYLGGD---------------GSNRWYRVTLQEG 308

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           RNR+VRRM   VG    RLIR   GD  L   L  G W E+
Sbjct: 309 RNREVRRMFESVGVTVSRLIRTRFGDLVLPRTLRRGRWEEL 349


>UniRef50_C8NNL7 Pseudouridine synthase n=8 Tax=Corynebacterium RepID=C8NNL7_COREF
          Length = 329

 Score =  206 bits (524), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 56/220 (25%), Positives = 89/220 (40%), Gaps = 23/220 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +     R +        R    +   N+     + NKP  +    +D+ GR 
Sbjct: 114 RVEVNGRIVTTQGTRVNP--NSDVIRVDGVRININEDLEYFVLNKPRGMHSTMSDDLGRP 171

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
            + + +       Q ++  GRLD D+EGLL+LTN+G L  RL  P     K Y   V G 
Sbjct: 172 CVGDLVSEKTASGQRLFHVGRLDADTEGLLLLTNDGELANRLMHPKYEVRKTYLATVRGE 231

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
              + +  LR G+ L DGP      +++D                    S +++ ++EGR
Sbjct: 232 AGPNLVTTLRKGIELEDGPAKADYVQIID---------------TFQGKSLIRLEIHEGR 276

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
              VRRM    GFP  RL+R  +    L     G  R + 
Sbjct: 277 KHIVRRMLDEAGFPVERLVRTKLHTVQLGEQKPGSLRALN 316


>UniRef50_Q49YI4 Pseudouridine synthase n=2 Tax=Staphylococcus RepID=Q49YI4_STAS1
          Length = 232

 Score =  205 bits (523), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 25/219 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q  I +        + +        +   +K +      ++ NKP D +   TDE   K
Sbjct: 25  KQVTIDDKVETSPKKQINP--ELEIVKVNDQKIDFVNKVYLMLNKPKDYISATTDEQ-HK 81

Query: 62  TLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + I       ++  GRLD+D+EGLL++TN+G     L  PGK   K Y V  +   T
Sbjct: 82  TVLDLIEDYRYLDLFPVGRLDKDTEGLLLITNDGQFNHELMSPGKHVAKTYEVISQKNIT 141

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++ + A + G+ LN+G   PA     DE    +                  +T+YEGR  
Sbjct: 142 KNDINAFKVGIELNEGLAKPAKLVQGDELNKSF------------------VTIYEGRYH 183

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           QV+RM   +    L L R  +GD  LD  LA+GE+R +T
Sbjct: 184 QVKRMFHAIDNEVLALKRIRIGDLQLDSTLASGEYRHLT 222


>UniRef50_B0S1L0 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S1L0_FINM2
          Length = 242

 Score =  205 bits (523), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 99/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   S   +QV          +K    +    I  NKP        D+   K
Sbjct: 26  KVYVNGTILLDLS---YQVNDTDIVEVEGKKINLKEDKIYIAINKPIGYASTVKDKFADK 82

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
            + + I     VY  GRLD+DS GLL+LTN+G     LT P     KIY V V+G P + 
Sbjct: 83  KVVDLIKSDTRVYPVGRLDKDSHGLLILTNDGEFTYELTHPKFEHKKIYEVLVKGKPNKT 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            ++ L++G+ L+      +  E ++                    +  ++T++EGRNRQ+
Sbjct: 143 EIKQLKDGILLDGYKLKKSKIEFIEN---------------VKNDTKYRVTIFEGRNRQI 187

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREV 215
           RRM   +  P L L R  +G+Y ++N L +GE++ +
Sbjct: 188 RRMFDFINHPVLDLKRVQIGNYKMENSLKSGEYKLL 223


>UniRef50_Q04F57 Pseudouridine synthase n=2 Tax=Oenococcus oeni RepID=Q04F57_OENOB
          Length = 237

 Score =  205 bits (522), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 49/216 (22%), Positives = 97/216 (44%), Gaps = 17/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           Q  ++   + K      +V          +K   +     L NKP   +        + +
Sbjct: 30  QVKVNGKIITKL---GKKVSSDDIVYVDNKKINEESFEYYLLNKPAGYVSSNRSYPNQPS 86

Query: 63  LKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + E I  +  +++ GRLD+D+ G+L+LTN+G L  +LT P  R  + Y   V+GI  +D 
Sbjct: 87  VIELIKTKTRIFSVGRLDQDTTGVLLLTNDGELTQKLTHPKHRIKRTYAAWVKGIVNEDE 146

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +E L   +  +     P  A ++             +  +    S ++IT+ EG+N +++
Sbjct: 147 IEQLTKPIRFDGEIYFPQAARIL-------------KVDQKRQESLIEITIAEGKNHEIK 193

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           ++   +G P ++L R      ++ NL  G+ R +++
Sbjct: 194 KILDFIGHPVIKLNRDMFDGITIGNLKKGQHRALSE 229


>UniRef50_C3BQR1 Pseudouridine synthase n=3 Tax=Bacillus RepID=C3BQR1_9BACI
          Length = 203

 Score =  205 bits (522), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 53/215 (24%), Positives = 85/215 (39%), Gaps = 25/215 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ--PTRVILFNKPYDVLPQFTDEAGRK 61
             I+    +        V          +  E +      I F+KP  +     D     
Sbjct: 1   MAINGEVCK----HGTIVTENDIVMIDGKTIEKEDKEKIYIAFHKPVGITCTAADHIDGN 56

Query: 62  TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            ++     + ++  GRLD+ SEGL++LTN+G +  ++        K Y V V+   T   
Sbjct: 57  IIEYINHPERIFPVGRLDKASEGLILLTNDGRIANQILHGDYEHEKEYIVTVDKPFTDWF 116

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           ++ +  GV + DG T       V                    +S  +I L +G NRQ+R
Sbjct: 117 IDGMSRGVKIKDGITKQCKVTRV-------------------NSSTFRIILTQGMNRQIR 157

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RM+   G+   +L R  + +  LD L  GEWR VT
Sbjct: 158 RMSRAFGYTVTKLKRVRIMNIKLDGLEAGEWRNVT 192


>UniRef50_A3JIZ1 Pseudouridine synthase n=1 Tax=Marinobacter sp. ELB17
           RepID=A3JIZ1_9ALTE
          Length = 367

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 57/218 (26%), Positives = 87/218 (39%), Gaps = 20/218 (9%)

Query: 3   QFIISENTMQ-KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           + +++   +          V     +R           RV+++NKP   +    D  GR 
Sbjct: 82  RLLVNGKPVTPGQKATVSDVFELDGKRLEVAAAAEVLRRVLIYNKPEGEVTTRKDPEGRP 141

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + +P        + GRLD ++ GL++ T +G L  RL  P     + Y V++ G   
Sbjct: 142 TVFDRLPRLREHRWISIGRLDLNTTGLVMFTTDGELANRLMHPSSEIDREYAVRIFGEVD 201

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
              +E LR GVTL DG    +                      +    W  +TL EGRNR
Sbjct: 202 DAMIERLRTGVTLEDGEAKFSDIS---------------AAGGTGMNRWFHVTLLEGRNR 246

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           +VRR+    G    RL R   G   L   L  G+W E+
Sbjct: 247 EVRRLWESQGVRVSRLKRVRYGSIFLPSRLTVGKWEEL 284


>UniRef50_C7H5G4 Pseudouridine synthase n=8 Tax=Clostridiales RepID=C7H5G4_9FIRM
          Length = 294

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 65/219 (29%), Positives = 104/219 (47%), Gaps = 22/219 (10%)

Query: 3   QFIISENTMQKTSFR--NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +  ++ + ++       N  V     +R      +NQ    +   KP   +   +DE GR
Sbjct: 46  RVKVNGHPVKVGDKMDPNRDVLHVDDERIY--IQKNQQLYYLALYKPRGYVTTASDELGR 103

Query: 61  KTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           KT+ E +      +Y  GRLD+DSEGLL++TN+GA    +T P     K+Y V V+    
Sbjct: 104 KTVMELVSDIPARLYPVGRLDKDSEGLLLMTNDGAFAQAVTHPSGGISKLYRVTVQPRAD 163

Query: 119 QDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           +  +  + +GV L+DG  T+P    +V +                   + +++TL EG+N
Sbjct: 164 ESQILKMSSGVVLDDGTKTMPCAINVVTDEPGR---------------TVMEMTLKEGKN 208

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R++RRM   VG   +RL R A G   L  L  G +RE+T
Sbjct: 209 REIRRMCEAVGLEVVRLKRNAEGVVKLGMLKPGTYRELT 247


>UniRef50_Q1J0B9 Pseudouridine synthase n=5 Tax=Deinococci RepID=Q1J0B9_DEIGD
          Length = 253

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 68/217 (31%), Positives = 92/217 (42%), Gaps = 27/217 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN--QPTRVILFNKPYDVLPQFTDEAGR 60
           +  ++       +     V      R   R  E   Q +   L  KP   +    DE GR
Sbjct: 31  RVTVNGQI----ATLGRTVMPDDEVRVDGRLIEAPAQESVTFLLYKPAGYVTTARDEYGR 86

Query: 61  KTLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + +   +P   G++  GRLD+DSEGLL+LT +G L   LT P     K Y     G P  
Sbjct: 87  RNVLSAMPPIPGLHPVGRLDKDSEGLLLLTTDGQLTLTLTHPRYGHEKAYRAWTAGQPVA 146

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L  L  G+ L DGP     A      A                     +TL EGRNRQ
Sbjct: 147 AELRVLETGIELADGPARALSARPARGGAL--------------------VTLTEGRNRQ 186

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM   +G+P  RL+RY +G   L +L  GE+R ++
Sbjct: 187 VRRMLDAIGYPVHRLLRYRVGGLWLGDLEPGEYRLLS 223


>UniRef50_B1ZYI5 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1ZYI5_OPITP
          Length = 188

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 89/176 (50%), Positives = 113/176 (64%), Gaps = 2/176 (1%)

Query: 43  LFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQ 100
             +KPY VL QFT E G +  TL EF     VY  GRLD DSEGLL+L++   L  RL  
Sbjct: 4   ALHKPYGVLSQFTPEPGSRWRTLAEFGLPPAVYPLGRLDADSEGLLLLSDEPGLNTRLLN 63

Query: 101 PGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRER 160
           P +   + Y+VQVE +PT  AL  L+ GV + D  T P  A  +D    L PR+PPIR R
Sbjct: 64  PDQAHRREYWVQVERVPTDAALAQLQRGVKIGDYATRPCAARRLDPAPTLPPRDPPIRAR 123

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           K++P  WL + L EG+NRQVRRMTA +G PTLRL+R  +GD++L  LA G+WRE+T
Sbjct: 124 KNVPDCWLALELIEGKNRQVRRMTAAIGHPTLRLVRVRIGDFALGKLAVGQWRELT 179


>UniRef50_A9KNY1 Pseudouridine synthase n=3 Tax=Firmicutes RepID=A9KNY1_CLOPH
          Length = 240

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 27/220 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           + +++ NT      +              R+         + NKP  V+    D   + T
Sbjct: 33  RVMVNGNTETSPETKV--DSNHDKIFVDSRELSYVTLEYFMLNKPAGVVSASND-KKQTT 89

Query: 63  LKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + + I     + ++  GRLD+D+EGLL++TN+G L  +L  P K   K+Y+ ++     +
Sbjct: 90  VVDLIDEAKRKDLFPVGRLDKDTEGLLIITNDGDLAHQLLSPKKHVDKVYFAKLRDPLKK 149

Query: 120 DALEALRNGVTLNDGPT-LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           +  EA   G+ +++  T LPA  E + E                       +T+ EG+  
Sbjct: 150 EDEEAFAAGLKIDEEFTALPAKLERISEQEAY-------------------VTIREGKFH 190

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVTD 217
           Q++RM        + L R +MG   LD  L+ GE+RE+T+
Sbjct: 191 QIKRMFEATRNEVIYLKRISMGSLVLDESLSLGEYRELTE 230


>UniRef50_Q1IR68 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IR68_ACIBL
          Length = 254

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 95/216 (43%), Gaps = 19/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++    +         +                    + NKP  ++   +DE GR+T
Sbjct: 38  EVRVNGKVERNPERPTDPAR--DRVEVAHIAIRAARFLYYVVNKPRGLITTASDEKGRET 95

Query: 63  LKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           +   +P     V   GRLD+ SEGLL+LTN+    A++T P     K Y+VQV  +P++ 
Sbjct: 96  IYSLLPPDSPWVAPVGRLDKASEGLLLLTNDSEWAAKITDPNSHLDKTYHVQVSTLPSEQ 155

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +EAL  G+  +    L     ++               R      WL+I L EG+NRQ+
Sbjct: 156 MVEALSRGIRSDGELLLAKRVSIL---------------RAGGKNGWLEIVLEEGKNRQI 200

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM A +    LRLIR A+G  +L  L  G  R +T
Sbjct: 201 RRMVAALQIEVLRLIRVAIGPLTLGELPKGGCRALT 236


>UniRef50_Q6MIA3 Putative pseudouridylate synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MIA3_BDEBA
          Length = 265

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 64/219 (29%), Positives = 98/219 (44%), Gaps = 18/219 (8%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP---TRVILFNKPYDVLPQFTDEAGR 60
             ++   + +      +V   S +     KP  +P       + NKP  VL    D   R
Sbjct: 7   VTVNGKRVYEL---GIKVDPQSDRILVDGKPLRKPLTQKIYAILNKPTGVLTTMDDPHDR 63

Query: 61  KTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
            T+ E++      V+  GRLD DSEG+L+LTN+G    ++  P     K Y V++ G P 
Sbjct: 64  PTVAEYLTELPVRVFPVGRLDWDSEGMLLLTNDGDFANKVMHPKAEVTKTYLVKLNGKPE 123

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
              LE L+ GV++  G       E +              + KS    W KI + EG+NR
Sbjct: 124 PFQLEKLKKGVSIVGGKVSARHIEKI----------KKTGDNKSEKYEWYKIVITEGKNR 173

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           Q+R+M A +GF  +RL R A+G   +  +  GE   + D
Sbjct: 174 QIRQMFAKIGFDVMRLQRVAIGRLRMGAVKTGELVYLND 212


>UniRef50_B2TQQ1 Pseudouridine synthase n=8 Tax=Clostridium RepID=B2TQQ1_CLOBB
          Length = 264

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 55/222 (24%), Positives = 103/222 (46%), Gaps = 12/222 (5%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + + S   ++  +        +K  +      +FNKP   +    D   R T+
Sbjct: 27  VKVNGEIITEPSIDINE--KLDDVEYLEKKVVHTGKVYYMFNKPSGCITATKDNIHR-TV 83

Query: 64  KEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            ++      GV+  GRLD+D+EGLL+LTN+G  + ++  P K   K Y+    G    + 
Sbjct: 84  FDYFDEDMNGVFHVGRLDKDTEGLLLLTNDGEFEHKVMHPEKHVEKTYFFWALGSLDDED 143

Query: 122 LEALRNGVTL--NDGPTLPAGAELVDEPAWLWPRNP----PIRERKSIPTSWLKITLYEG 175
            + L+ GV +  N+  T PA  ++    +++  +       ++ +   P     +T+ EG
Sbjct: 144 KKQLQEGVFIGSNEALTKPAKIDIHKSGSYIEFKEEIPINSLKNKDHQPVVSGYLTISEG 203

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
           +  QV+RM   VG   + L R ++G   LD  L  G++R++T
Sbjct: 204 QKHQVKRMLKAVGCYVIYLKRISIGGLKLDESLKMGDYRDLT 245


>UniRef50_B7L142 Pseudouridine synthase n=9 Tax=Alphaproteobacteria
           RepID=B7L142_METC4
          Length = 674

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 98/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V             P  + TR+ L +KP  V+    D  GR 
Sbjct: 47  RVTLNGKVLTSPAIN---VTDSDRITVDDEPLPARERTRLWLLHKPRGVVTTARDPEGRP 103

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P +   V A GRLD ++EGLL+LTN+G L   +  P     + Y V+  G  TQ
Sbjct: 104 TVFDGLPEELPRVVAIGRLDINTEGLLLLTNDGGLAKVIAHPDTGWLRRYRVRAFGDVTQ 163

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L+ G+T++     P  A L               +R      WL + L EG+NR+
Sbjct: 164 PDLDKLKKGLTVDGMEYGPIEATL---------------DRAQGDNVWLTLGLREGKNRE 208

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+R+  H+G    RLIR + G + L +L  G   E+
Sbjct: 209 VKRILEHLGLSVNRLIRLSFGPFQLGDLEVGLVEEI 244


>UniRef50_A0Z1Z6 Pseudouridylate synthase n=2 Tax=Proteobacteria RepID=A0Z1Z6_9GAMM
          Length = 208

 Score =  204 bits (519), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 87/177 (49%), Positives = 113/177 (63%), Gaps = 4/177 (2%)

Query: 39  TRVILFNKPYDVLPQFTDEAGRK---TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQ 95
             +IL NKP+ VL QF+D        TL   +       AGRLD DSEGL +LT++G LQ
Sbjct: 24  PDIILLNKPFRVLSQFSDRDNDPPRLTLANLLSAPEFRVAGRLDYDSEGLTLLTDDGKLQ 83

Query: 96  ARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNP 155
            ++  P  +  K Y+VQVEG P Q A+E L +GV LNDG T PA    +D P  LW R+P
Sbjct: 84  QQIANPKFKVWKTYWVQVEGAPKQQAIEQLTSGVVLNDGLTKPAKVRAIDPPD-LWERSP 142

Query: 156 PIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
            +R R  IP +WL+I++ EGRNRQ+RRMTA V  PTLRL+R A+GD+ + NL  GE+
Sbjct: 143 SVRFRAHIPDAWLEISIQEGRNRQIRRMTAAVNLPTLRLVRIAIGDWEIGNLQPGEY 199


>UniRef50_C7PFL3 Pseudouridine synthase n=3 Tax=Bacteria RepID=C7PFL3_CHIPD
          Length = 389

 Score =  204 bits (519), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 52/220 (23%), Positives = 94/220 (42%), Gaps = 26/220 (11%)

Query: 4   FIISENTM--QKTSFRNHQVKRFSSQRSTRRKP---ENQPTRVILFNKPYDVLPQFTDEA 58
            I S   +   + +   ++ K   +           + +    +  NKP   +   T+  
Sbjct: 25  LITSGRVLLNDRPAALGNRYKPGDTVEVDGSLITAAKKEKRVYLALNKPPG-ITTTTELH 83

Query: 59  GRKTLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            +  +  F+   Q ++  GRLD+DSEGL+ LTN+G +  ++ +      K Y V+V    
Sbjct: 84  IKDNIISFVNYPQRIFPIGRLDKDSEGLIFLTNDGDIINKILRAANNHEKEYVVRVNKPI 143

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
             + L  +  GV + D  TLP   ++                         +ITL +G N
Sbjct: 144 DTNFLHQMSQGVPILDTRTLPCKVQMTGRQ-------------------TFRITLTQGLN 184

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RQ+RRM  ++G+  + L R  + +  LD L  G+WR +++
Sbjct: 185 RQIRRMCEYLGYTVVGLQRVRIMNVRLDKLPLGKWRYLSE 224


>UniRef50_B3QY10 Pseudouridine synthase n=10 Tax=Chlorobiaceae RepID=B3QY10_CHLT3
          Length = 297

 Score =  203 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 62/218 (28%), Positives = 101/218 (46%), Gaps = 24/218 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           + +++   + +  ++  +  R        +K  EN     IL NKP DV+   +DE  RK
Sbjct: 68  EVMVNGKVVMELGYKVDR--RADEVVVNGKKLHENTQKIYILLNKPKDVVTTSSDEKSRK 125

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ E +     V+  GRLDRD+ G+L+LTN+G L  RLT P     K Y   ++   T  
Sbjct: 126 TVVELVGLKDRVFPVGRLDRDTTGVLLLTNDGDLTYRLTHPTFGVQKQYVATLDKKITSV 185

Query: 121 ALEALRNGVTLND--GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            L+ ++ G  L D      P  A ++D+   +W                  + ++EG+N 
Sbjct: 186 DLQNIKKGFRLKDTGEKVSPCNARILDDGYTIW------------------VAIHEGKNH 227

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           Q+ RM    G+   +L+R A G   +  +  GEWR +T
Sbjct: 228 QIHRMFWSFGYNVKKLVRVAYGGLEVGTMRRGEWRFLT 265


>UniRef50_A8U325 Pseudouridine synthase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U325_9PROT
          Length = 387

 Score =  203 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  +    +   +     V   S      +  PE +P R+  ++KP  ++    D  GR 
Sbjct: 34  RVKVDGVMLTSPAVN---VDDDSVILVDEKPLPEIEPPRLWRYHKPDGLVTSNRDPEGRS 90

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V   GRLD DSEGLL+LTN+G L   L  P     + Y V+V G   +
Sbjct: 91  TVFDRLPKDLPRVVTVGRLDIDSEGLLLLTNDGGLARYLELPSTGWVRRYRVRVFGPLDE 150

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L+ GV +      P    +               ++ +   SWL + L EG+NR+
Sbjct: 151 AKLDNLKKGVRIEGVEYGPIEVTI---------------DKATRTNSWLTVALREGKNRE 195

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +RR+  HVG    RLIR   G + L  +  G   E+
Sbjct: 196 IRRVMEHVGLTVSRLIRTTYGPFQLGEVPPGGVEEI 231


>UniRef50_Q3MC44 Pseudouridine synthase n=21 Tax=Cyanobacteria RepID=Q3MC44_ANAVT
          Length = 288

 Score =  203 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 67/229 (29%), Positives = 100/229 (43%), Gaps = 33/229 (14%)

Query: 3   QFIISENTMQKTSFRNHQVKRF-SSQRSTRRKPENQPTR---VILFNKPYDVLPQFTDEA 58
           +  I+       +    +V           +    Q       +L NKP  V+    D  
Sbjct: 54  RVQINGT----LAELGQKVNPERDIITVDGKSVSAQRHHRLTYLLLNKPTGVVSTCYDPQ 109

Query: 59  GRKTLKEFIPVQ-----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQV 113
           GRKT+ + +P +     G++  GRLD  S G L+LTN+G L  +LT P     K Y + V
Sbjct: 110 GRKTVLDLLPEELRKGSGLHPVGRLDAYSTGALILTNDGDLTFKLTHPSHNIPKTYQILV 169

Query: 114 EGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
           +G P +  L+  R GV L+   T  A   L++  A                 S L+I L 
Sbjct: 170 KGHPPEAVLKMWREGVLLDGRKTRKAKVSLLESLAEK---------------SRLEIVLQ 214

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-----LANGEWREVTD 217
           EGRNRQ+RR+   +G+P ++L R A+G   L       L  G +R + D
Sbjct: 215 EGRNRQIRRVAEQLGYPVIKLHRTAIGSIQLQTSKQPLLRAGNYRILRD 263


>UniRef50_Q6G8H4 Pseudouridine synthase n=61 Tax=Firmicutes RepID=Q6G8H4_STAAS
          Length = 231

 Score =  203 bits (517), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 98/221 (44%), Gaps = 24/221 (10%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGR 60
           +++ +++ N     S + H               E      I+ NKP D +    D    
Sbjct: 22  LKKGLVNVNEQVIKSPKTHIEPENDKITVRGELIEYIENVYIMLNKPKDYISATED-HHS 80

Query: 61  KTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           KT+ + IP      ++  GRLD+D+EGLL++TN+G     L  P K   K Y V      
Sbjct: 81  KTVIDLIPEYQHLNIFTVGRLDKDTEGLLLITNDGDFNHELMSPNKHVSKKYEVISANPI 140

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           T+D ++A + GVTL+DG   PA    +D                        +T+YEG+ 
Sbjct: 141 TEDDIQAFKEGVTLSDGKVKPAILTYIDNQTS-------------------HVTIYEGKY 181

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
            QV+RM   +    L L R  + D  LD NL +GE+R +T+
Sbjct: 182 HQVKRMFHSIQNEVLHLRRIKIADLELDSNLDSGEYRLLTE 222


>UniRef50_C5CXG1 Pseudouridine synthase n=4 Tax=Comamonadaceae RepID=C5CXG1_VARPS
          Length = 604

 Score =  203 bits (517), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 56/227 (24%), Positives = 90/227 (39%), Gaps = 25/227 (11%)

Query: 1   MRQFIISEN--TMQKTSFRNHQVKRFSSQRSTRR----KPENQPTRVILFNKPYDVLPQF 54
           M   I+        + +    +++     +   +    +    P RVI ++KP   +   
Sbjct: 215 MEALILQGRISVNNEPAHIGQRIQYGDQVKINGKPIRYRIAPPPPRVIAYHKPVGEVVTH 274

Query: 55  TDEAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYV 111
            D   R T+   +P        + GRLD ++EGLL+ +++G L  +L  P     + Y V
Sbjct: 275 DDPQNRPTVFRKLPRLQQGKWQSVGRLDLNTEGLLLFSSSGDLANQLMHPRFGLEREYAV 334

Query: 112 QVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKIT 171
           +V G    +  + L  GV L+DG                                W ++T
Sbjct: 335 RVLGALNAEEKKKLLEGVRLDDGMAQFGTI---------------EEGGGEGSNHWYRVT 379

Query: 172 LYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           + EGRNR+VRR+   VG    RLIR   G   L   L  G W E+ +
Sbjct: 380 ISEGRNREVRRLFESVGHAVSRLIRIRYGAMVLPRGLKRGAWMELDE 426


>UniRef50_B9MRL6 Pseudouridine synthase n=2 Tax=Clostridia RepID=B9MRL6_ANATD
          Length = 233

 Score =  203 bits (517), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 55/215 (25%), Positives = 98/215 (45%), Gaps = 26/215 (12%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT- 62
             ++   + +  F+ +            R  +      I+ NKP   +    + A     
Sbjct: 27  VTVNGKQIVEVDFKINP--EEDIIEVDGRVAKFSKQIYIMMNKPKGYVCSNEELASLTVF 84

Query: 63  --LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
             + + +  + ++  GRLD+D+EGLL++T++G    R+  P KR  K Y V++E    ++
Sbjct: 85  SLISDDLKYRDLHTVGRLDKDAEGLLIITDDGEYTHRVISPKKRIEKEYLVRLEKEVDEE 144

Query: 121 ALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            L    NG+ L+DG  TLPA   ++D                    + +K+ +YEG+  Q
Sbjct: 145 KLNEFENGIILDDGYKTLPAKYTIIDS-------------------TTVKLCIYEGKYHQ 185

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWR 213
           V+RM   +G   + L R  +G  +LD +L  GE+R
Sbjct: 186 VKRMFEAIGNKVVDLKRLRIGGLNLDQSLKPGEYR 220


>UniRef50_Q3B289 Pseudouridine synthase n=2 Tax=Chlorobium/Pelodictyon group
           RepID=Q3B289_PELLD
          Length = 250

 Score =  202 bits (516), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 60/217 (27%), Positives = 99/217 (45%), Gaps = 21/217 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  I+     +   +    K       ++          ILFNKP +V+   +DE  R+ 
Sbjct: 38  RVTINGVLASEPGVKVVPGKDEVIVDGSKFAQPEGRKIYILFNKPRNVITTSSDERNREM 97

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + +FI   + VY  GRLDR + G+L+LTN+G L  +L  P     K Y   ++    Q +
Sbjct: 98  VLDFIDVNERVYPVGRLDRKTTGVLLLTNDGMLANKLMHPSSNVKKEYIAVLDAPFPQAS 157

Query: 122 LEALRNGVTLND--GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           L  L  G+ L+D      P  A+++ + + +W                  I+++EG+N Q
Sbjct: 158 LPLLTGGMRLSDTGEKVSPCQAKIMGDGSQVW------------------ISIHEGKNHQ 199

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRRM   +GF   RL R      ++ +L  G+WR +T
Sbjct: 200 VRRMFKTLGFEVTRLDRPTYAGLTVGDLRRGQWRHLT 236


>UniRef50_B0SBU8 Pseudouridine synthase n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SBU8_LEPBA
          Length = 243

 Score =  202 bits (516), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 53/220 (24%), Positives = 91/220 (41%), Gaps = 26/220 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   ++      +++               +     + NK  D +    D    KT+
Sbjct: 30  VKVNGLVVKDP---GYKITLTDIVVYYDETLNRKEFYYFMMNKAPDCITATEDPRE-KTV 85

Query: 64  KEFIPVQG----VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            +++  +     ++  GRLD+++EGLL+ T +G L    T P     K YY ++    T 
Sbjct: 86  MDYLSERHRNMNLFPIGRLDKETEGLLLFTTDGTLAHYYTSPKHFVEKEYYAEISAPVTA 145

Query: 120 DALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
             +    +G+TL+DG  TLPA   + D                        + L EG+ R
Sbjct: 146 FDISQFESGITLDDGYKTLPARLAIPDPS----------------NPHIATVWLREGKYR 189

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           Q+RRM   +G     L R  MG+  LD +L  G +RE+T+
Sbjct: 190 QIRRMFQSLGKEVQYLKRVKMGNLELDRDLEVGSYRELTE 229


>UniRef50_Q2S2G3 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2G3_SALRD
          Length = 249

 Score =  202 bits (516), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 24/218 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  I    + +       V+   +      +        +L NKP D +    D   R+T
Sbjct: 36  RVHIDGERVDQ---HGTCVREGQTVTVDGEEVYPLEFEYLLLNKPKDTISTTDDPKDRRT 92

Query: 63  LKEFIPVQ-----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           + + I V      G++  GRLDR++ G+L+++N+G L  RL  P     KIYYV+V+   
Sbjct: 93  VLDAIGVPEDNPSGLFPVGRLDRNTTGVLLVSNDGDLAHRLMHPRYEIPKIYYVRVQDDV 152

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
               L+ L+ GV L+DG         +D                    + + + L+EGRN
Sbjct: 153 KPHQLDQLKRGVELSDGAAAADQVAYLDP----------------QRKTDIALELHEGRN 196

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RQ+RRM   +G   ++L R      +   L  GEWR +
Sbjct: 197 RQIRRMMEALGHTIVQLERAKYATLTTGRLQRGEWRRL 234


>UniRef50_A9MDW0 Pseudouridine synthase n=43 Tax=Rhizobiales RepID=A9MDW0_BRUC2
          Length = 611

 Score =  202 bits (516), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 102/216 (47%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   ++  +     VKR        +   + + TR+ L++KP  ++    D  GR 
Sbjct: 129 RIAVNGKVLESPAVN---VKRTDIITVDGKPLRQTERTRLWLYHKPAGLVTTNRDPEGRP 185

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ E +P +   V + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G  TQ
Sbjct: 186 TVFEALPPEMPRVLSVGRLDINTEGLLLLTNDGGLSRVLELPSTGWLRRYRVRAHGKVTQ 245

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L+NG+ ++        AEL               ER      W+ I L EG+NR+
Sbjct: 246 QQLDELKNGIAVDGVFYGSVEAEL---------------ERVQGANVWISIGLREGKNRE 290

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+ +   +G    RLIR + G + L +L  G  RE+
Sbjct: 291 VKNILGALGLTVGRLIRVSFGPFQLGDLEEGAVREI 326


>UniRef50_D0U645 Pseudouridine synthase n=1 Tax=uncultured actinobacterium
           RepID=D0U645_9ACTN
          Length = 237

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 56/218 (25%), Positives = 92/218 (42%), Gaps = 24/218 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +++   +                         +  +KP  VL    D  GR 
Sbjct: 29  RVAVNGIIVREMGSK--FDPEMDKVMVDGETITRTLTKSYLALHKPKGVLSTMFDPEGRP 86

Query: 62  TLKEF--IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           +L +F  +  + ++  GRLD+DSEGL++LTN+G L  R T P     K Y ++ +GI   
Sbjct: 87  SLDDFIDLRKERLFHVGRLDKDSEGLILLTNDGDLTFRATHPSFGLEKTYIIEFDGILPT 146

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
              + L  GV L DG       + +                      W++++++EGR   
Sbjct: 147 GVDKVLLKGVELEDGMGRVLTFKQLSPK-------------------WIEVSIHEGRYHI 187

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +RR+   VG   LRLIR   G  SL +   G WR++ D
Sbjct: 188 IRRLMEAVGVNVLRLIRTKFGPISLGDTPEGRWRDLND 225


>UniRef50_B0RHF4 Pseudouridine synthase n=3 Tax=Actinobacteria (class)
           RepID=B0RHF4_CLAMS
          Length = 291

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 90/216 (41%), Gaps = 18/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK- 61
           +  ++  T+ +   R        +    +    +   R ++ NKP  +     DE GR  
Sbjct: 50  RVTVNGETVTEPGRRIDPDVDEVAV-DDQAVQLDTSKRYLMLNKPVGIYSSLRDERGRPD 108

Query: 62  -TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
                    + ++  GRLD ++ GLL+LTN+G L   L  P     K Y  +V G  T  
Sbjct: 109 LREFTEEFEERLFNVGRLDAETSGLLILTNDGDLAHVLAHPSFGVLKTYIAKVTGRVTPQ 168

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            ++ L  GV L DGP     A ++                     + ++ITL+ GRNR V
Sbjct: 169 TIQRLTQGVDLEDGPIQADRARILSG---------------GGDQTLVEITLHSGRNRIV 213

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM   VG P   L+R   G   L +L  G  R++T
Sbjct: 214 RRMLDEVGHPVEELVRRQFGPLHLGSLGVGRVRDLT 249


>UniRef50_C8WBY9 Pseudouridine synthase n=3 Tax=Zymomonas mobilis RepID=C8WBY9_ZYMMN
          Length = 509

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 98/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I   T++K +     +          +       TR+ L++K   +L    D  GRK
Sbjct: 296 RIAIDGVTVEKPATL---LTSLDGVTVDGKPVNAPTETRLFLYHKATGLLTTERDPEGRK 352

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V   GRLD ++EGLL+LT +G  +  L  P     + Y  +V G  +Q
Sbjct: 353 TIYDRLPADLPRVMPVGRLDMNTEGLLLLTTDGGFKRMLELPATHIERCYRARVFGDVSQ 412

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           D LE L  GVT++                          ER++    W+++ L+EGRNR+
Sbjct: 413 DQLEELIEGVTIDGIHY---------------GSIDANLERRTGRNGWVEMKLHEGRNRE 457

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VRR+  ++G    RLIR + G + L +L  G   EV
Sbjct: 458 VRRVLGYLGLQVSRLIRISYGPFLLGDLPVGAVEEV 493


>UniRef50_A3M7K0 Pseudouridine synthase n=13 Tax=Acinetobacter RepID=A3M7K0_ACIBT
          Length = 262

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 95/178 (53%), Positives = 122/178 (68%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++ NKPYDVL QF  +    T+ +F+    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVILNKPYDVLSQFRKDEAHMTVSDFVDDPTLRIAGRLDMDSEGLVFLTDHGGLNQFIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T++ALE LR GV LNDG TLPA A  V EP WLW R+PP+R 
Sbjct: 62  NPANKKYKTYLVQVDGDVTEEALEQLRKGVELNDGMTLPAKAIKVSEPEWLWDRDPPVRY 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD--NLANGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMT+ VGFPTLRLIR  +G   L    L  GE +E+
Sbjct: 122 RASIPTSWIEISICEGRNRQVRRMTSAVGFPTLRLIRTKIGTIDLVQLGLQPGETKEI 179


>UniRef50_C8PSZ6 Ribosomal large subunit pseudouridine synthase B n=1 Tax=Treponema
           vincentii ATCC 35580 RepID=C8PSZ6_9SPIO
          Length = 252

 Score =  202 bits (514), Expect = 7e-51,   Method: Composition-based stats.
 Identities = 46/218 (21%), Positives = 87/218 (39%), Gaps = 26/218 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRK 61
           +  ++   +        +V    +     +    +  +  +L NKP   +   +DE GR 
Sbjct: 40  RVSVNGTVVTG---MGSKVCAGDTVLFDGKPVHPEARKCYVLLNKPAGFVCTLSDEKGRP 96

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T  + +     + +Y  GRLD  S G ++ TN+G   A++  P  +  K Y ++      
Sbjct: 97  TAADLLKEAYSERLYNIGRLDMFSSGAILFTNDGDFAAKIEHPSAQIEKEYVIETTQDFP 156

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            + L     G+ ++                         R   ++    L+I L EG+NR
Sbjct: 157 PELLTRFERGIRVDGIFYK-------------------CRSAAAVNRRKLRIVLVEGKNR 197

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++RR+         RL+R  +G+  L  L  GE+R++T
Sbjct: 198 EIRRVLDSFNCTIKRLVRVRIGNLELGTLKAGEFRDLT 235


>UniRef50_UPI0001C37AA4 16s pseudouridylate synthase n=2 Tax=Ruminococcus flavefaciens FD-1
           RepID=UPI0001C37AA4
          Length = 255

 Score =  202 bits (514), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 52/218 (23%), Positives = 93/218 (42%), Gaps = 26/218 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++ + ++++  +                  ++  R IL NKP   +    D+ G +T+
Sbjct: 30  VTVNGSPVKRSDTKI--DTGADDVTVCGNAISSERFRYILLNKPKGYVSSTDDKDG-ETV 86

Query: 64  KEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            + +P +    G++ AGRLD+DS G L++T++GAL  R+  P     KIY  ++     Q
Sbjct: 87  IKLVPPEMRSKGLFPAGRLDKDSTGALLITDDGALAHRICSPNNHISKIYAAELSRPFEQ 146

Query: 120 DALEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           + +E    G+ L +G    P   +  +    L                   + L+EG   
Sbjct: 147 EYVEKFAKGIVLANGEACSPCKVQKAENADNLAF-----------------VELHEGMYH 189

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           QV+RM A VG     L R ++G   L  +L  G+   +
Sbjct: 190 QVKRMFAAVGNHVENLKRISIGGLILPKDLPLGKCMYL 227


>UniRef50_A8ZRV1 Pseudouridine synthase n=3 Tax=Desulfobacteraceae
           RepID=A8ZRV1_DESOH
          Length = 241

 Score =  202 bits (514), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 53/217 (24%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +   +               +    +    I  NKP   +     +    
Sbjct: 35  RVAVNGQVVTELGTKV--DPESDDVMFDGHRVTLAESHVYIALNKPPGYVTSCL-QKQET 91

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ E +   Q V+  GRLD+ S GLL++T++G L  RL+ P     K Y V  +   +  
Sbjct: 92  TVMELVAVDQRVFPVGRLDKPSCGLLLMTSDGGLHQRLSHPSFDHEKEYDVACDRPVSDA 151

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+A+R G+ +    T PA  + + +                       I L EGRNRQ+
Sbjct: 152 DLDAMRRGMVITGRKTRPAKVKRLSDRR-------------------FLIILQEGRNRQI 192

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RRM   +G   + L R  +    L +LA G WR +T+
Sbjct: 193 RRMAEMLGNRVVLLRRIRIAHIHLGDLAEGRWRYLTE 229


>UniRef50_C1DTU8 Pseudouridine synthase n=5 Tax=Bacteria RepID=C1DTU8_SULAA
          Length = 247

 Score =  202 bits (514), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 23/221 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQF-TDEAGR 60
           +  ++  T++    +    K         +  +  +    +   KP   L     D  GR
Sbjct: 27  KVKVNGKTVKNLGLKIDPKK--DVVEVEGKIVKPTEKKIYLAIYKPVGYLSAVGKDRFGR 84

Query: 61  KTLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           KTL +F+        ++  GRLD +SEGLL+LTN+G    ++  P     K+Y V+V G 
Sbjct: 85  KTLTDFLNELKIPYKLFPVGRLDYNSEGLLILTNDGEFANKVAHPRNEIKKVYKVKVAGE 144

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            +Q+ L+ +  G  L DG   P   +++               ++    +WL + ++ G+
Sbjct: 145 VSQETLKKMEEGTILEDGFFKPDKIKML---------------KREEDGTWLLVEIHSGK 189

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
            R +RR     G    RLIR  +G   + NL   ++R +++
Sbjct: 190 KRIIRRFMDSFGHRVKRLIRVKIGSIDIGNLKPFDYRYLSE 230


>UniRef50_Q0G3T3 Pseudouridine synthase n=4 Tax=Alphaproteobacteria
           RepID=Q0G3T3_9RHIZ
          Length = 639

 Score =  201 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 101/216 (46%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     VK            P+ + TR+ LF+KP   +    D  GR+
Sbjct: 209 RVKVNGKIIDSPAL---DVKPTDRIEVDGALLPQAERTRLWLFHKPAGTVTTNKDPEGRR 265

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G  TQ
Sbjct: 266 TVFDMLPEDMPRVLSIGRLDINTEGLLLLTNDGGLSRVLELPSTGWLRRYRVRAHGSITQ 325

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ LRNG++++        A L               +R+     W+ + L EG+NR+
Sbjct: 326 AKLDELRNGISVDGVFYGAIEATL---------------DREQGSNVWITLGLREGKNRE 370

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+ +   +G    RLIR + G + L +LA G  REV
Sbjct: 371 VKNVLGALGLEVNRLIRLSYGPFQLGDLAEGSVREV 406


>UniRef50_A5EVQ2 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EVQ2_DICNV
          Length = 266

 Score =  201 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 23/223 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-----ENQPTRVILFNKPYDVLPQFTDE 57
           +  +        +    ++          +          P  +++++KP   +    D 
Sbjct: 34  RLKVDGRV----AELGQKISGNERLSLDGKPLRIAVEHKNPHMILMYHKPAGEICTRKDP 89

Query: 58  AGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
            GR ++ + +P        A GRLD ++ GLL+ TN+GAL  +L  P     + Y+V+V 
Sbjct: 90  EGRVSVFQHLPKISHGRWVAIGRLDLNTSGLLLFTNDGALANQLMHPSAEIEREYWVRVA 149

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
           G  T++ L ALR G+ L+DG                      + E  +    +  +TL E
Sbjct: 150 GEVTEEMLTALRQGIPLDDGLARFTEI----------CPLKTLHEDDTQFNRYFSVTLKE 199

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
           GRNR+VRR+   VG    RL R   G  SL  +L+ G  R +T
Sbjct: 200 GRNREVRRLWEAVGCKVSRLKRIRYGTISLPPSLSAGRHRLLT 242


>UniRef50_Q5SLZ5 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q5SLZ5_THET8
          Length = 243

 Score =  201 bits (512), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 59/215 (27%), Positives = 95/215 (44%), Gaps = 21/215 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    ++       +V   ++     R  E +    +L +KP   +   T+      
Sbjct: 29  KVRVLGQVVKDP---GFRVPEGAALEVEGRPLEVRRHLHVLLHKPPGFVTSRTEGPSVYA 85

Query: 63  LKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDAL 122
           L +  P + +   GRLD+D+EGLL+ T +G L  RLT P  +  K Y V +E        
Sbjct: 86  LLQGFPTRDLSPVGRLDKDAEGLLLFTTDGLLLHRLTHPRHKVAKRYLVHLERPVGPKDQ 145

Query: 123 EALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRR 182
           EA R G+ L+   TLPA    +++P                  +W ++ L EGR  Q++R
Sbjct: 146 EAFREGILLDGKKTLPAELTPLEDP------------------TWAEVVLKEGRFHQIKR 187

Query: 183 MTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           M    G   LRL R A+G   L +L  G+ R +T+
Sbjct: 188 MFRARGNRVLRLKRLALGPLELGDLPPGKARPLTE 222


>UniRef50_B0T1Z8 Pseudouridine synthase n=1 Tax=Caulobacter sp. K31
           RepID=B0T1Z8_CAUSK
          Length = 501

 Score =  201 bits (512), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 99/216 (45%), Gaps = 16/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +    +V+         +   E + TRV  ++KP  ++    D   R 
Sbjct: 49  RVALNGEVLTTPAI---KVRPGDILTVDGKMIDEPEATRVFRYHKPSGLMTTHNDPKQRP 105

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     + + GRLD +SEGLL+LTN+GAL   L  P     + Y  +  G  TQ
Sbjct: 106 TVFQALPRDLPRLISVGRLDLNSEGLLLLTNDGALSRALEMPQNAWVRRYRARAFGDTTQ 165

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L++G T+      P  A L          +    +       W+ +TL EG+NR+
Sbjct: 166 AKLDKLKDGCTVEGVRYGPIEARL----------DKAQEKAGGGKNIWITLTLSEGKNRE 215

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VRR+   +G    RLIR + G ++L  L  G+  EV
Sbjct: 216 VRRVLESIGLKVNRLIRLSYGPFALGTLLPGQVEEV 251


>UniRef50_B4W9R3 Pseudouridine synthase n=2 Tax=Brevundimonas RepID=B4W9R3_9CAUL
          Length = 519

 Score =  201 bits (512), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 100/216 (46%), Gaps = 12/216 (5%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V R        +     Q TRV  ++KP  +L   +D  GR 
Sbjct: 111 KVAVNGRILDTPATL---VTRDDVITVDGKPIGSTQATRVWRYHKPAGLLTSHSDPTGRP 167

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V + GRLD  +EGLL+LTN+G L   L  P     + Y  +  G  TQ
Sbjct: 168 TVFDALPAGLPRVISVGRLDLATEGLLLLTNDGELSRALELPATSLVRQYRARARGKITQ 227

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+ L++GV ++     P  A L         +     + ++    W+ +++ EG+NR+
Sbjct: 228 EQLDKLKDGVVVDGVSYGPIEATL------DKAKESKSEDGRAPANLWISVSITEGKNRE 281

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VR++   VG    RLIR A G + LD L  G   EV
Sbjct: 282 VRKVLESVGLTVNRLIRLAYGPFRLDVLPIGSVEEV 317


>UniRef50_D0BMY5 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BMY5_9LACT
          Length = 237

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 62/225 (27%), Positives = 99/225 (44%), Gaps = 25/225 (11%)

Query: 1   MRQFIISENTMQKTSFRNHQVKRFS----SQRSTRRKPENQPTRVILFNKPYDVLPQFTD 56
           M++ I S   +  ++   H                 + E+   +  L NKP  V+   TD
Sbjct: 18  MKKLISSGEVLIDSTPATHVSNNVDPQIQVITVQGSRMEDNSQKYYLLNKPKGVITATTD 77

Query: 57  EAGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQV 113
                T+ +    +   G+Y  GRLDRD+EGLL++TNNG L  RL  P +   K YYV+V
Sbjct: 78  SQ-LPTVIDLFKNENIEGLYPIGRLDRDTEGLLIITNNGPLGYRLLNPIQHIEKEYYVEV 136

Query: 114 EGIPTQDALEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
            G      ++   +G+  +DG    PA   +++                S   S   +T+
Sbjct: 137 NGPLDNSCIQRFYDGIMFHDGTICKPAKLSILES---------------SPSFSKATVTI 181

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
            EG+  Q+++M   VG     L R   G++ LD  L+ GE+R + 
Sbjct: 182 SEGKFHQIKKMFLCVGVKVTFLKRIRFGEFLLDESLSPGEYRPLN 226


>UniRef50_D0LG91 Pseudouridine synthase n=3 Tax=Bacteria RepID=D0LG91_HALO1
          Length = 553

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 96/216 (44%), Gaps = 19/216 (8%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             ++   + +   +   V               +    +L NKP   L   TD   R T+
Sbjct: 31  VSVNGQRVTELGTKV--VPGRDRVSVRGEAVYPEEPFYVLLNKPKGCLTAVTDPENRPTV 88

Query: 64  KEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            E++      V   GRLD  SEG+L+LTN+G L ARL  P     K Y+V+V    T+  
Sbjct: 89  MEYLHGLPARVVPVGRLDFYSEGVLLLTNDGDLSARLQSPRHHVEKTYHVKVRDQVTERH 148

Query: 122 LEALRNGVTLNDGP-TLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
           LE LR GV L DG  T PA  +++                      WL ITL EG++RQ+
Sbjct: 149 LEVLRQGVRLEDGTVTRPAQIDMLG--------------GTKSRHDWLVITLTEGKSRQI 194

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            RM   +G+  ++L R A G  +   L  G+ RE+T
Sbjct: 195 HRMLGVLGYTVMKLQRVAFGGLTFHGLRVGDARELT 230


>UniRef50_B2IHU4 Pseudouridine synthase n=1 Tax=Beijerinckia indica subsp. indica
           ATCC 9039 RepID=B2IHU4_BEII9
          Length = 528

 Score =  201 bits (511), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 24/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   + +       V           K   +  TR+ LF+KP  ++    D  GR 
Sbjct: 115 RVSVNGTVLTQPGV---SVSDEDVILVDGEKLAARGHTRLFLFHKPRGLVTTNHDPEGRP 171

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ +++         V + GRLD ++EGLL+LTN+G L   L  P     + Y V+ +G 
Sbjct: 172 TVFDYLHERHPDMPRVLSIGRLDINTEGLLLLTNDGGLSRLLELPTTGWVRRYRVRAKGT 231

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
             Q  L+ LR G+T++                          +R+    SWL ++L EG+
Sbjct: 232 TDQAVLDQLRQGITIDGIHYAGMEVTF---------------DREQGANSWLTLSLREGK 276

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           NR+V+R+   +G    RLIR + G + L +L  G+  EV
Sbjct: 277 NREVKRVLEQIGLEVNRLIRLSFGPFQLGDLPEGDVTEV 315


>UniRef50_B6R892 Pseudouridine synthase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R892_9RHOB
          Length = 681

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++ N +   +F    V +        +  P  + TR+ LF+KP   +    D  GRK
Sbjct: 62  RVSVNGNVLDTPAFT---VTQKDKVYVDGKPLPTRERTRLWLFHKPRGTVTTNKDPEGRK 118

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V   GRLD ++EGLL+LTN+G L   +  P     + Y V+  G  TQ
Sbjct: 119 TVFDILPKDMPRVVTVGRLDINTEGLLLLTNDGGLSRVIELPATGWLRRYRVRAFGKVTQ 178

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+AL++GV ++        A L               + +     WL I L EG+NR+
Sbjct: 179 EQLDALKDGVAIDGVLYGAIEATL---------------DTEKGDNVWLTIGLREGKNRE 223

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+R+  H+     RLIR + G + L +L  GE +E+
Sbjct: 224 VKRILEHLDLSVNRLIRISFGPFQLGDLGEGELQEI 259


>UniRef50_A8S8D3 Pseudouridine synthase n=1 Tax=Faecalibacterium prausnitzii M21/2
           RepID=A8S8D3_9FIRM
          Length = 233

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 56/221 (25%), Positives = 93/221 (42%), Gaps = 27/221 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++    +K      Q+K   +          Q    ++ NKP  V+   TD+    T
Sbjct: 26  RVQVNGAVCKKGDT---QLKDTDTVAVDGALLTYQKFVYLMLNKPEGVVSASTDKRD-TT 81

Query: 63  LKEFI----PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +    P + ++ AGRLD+ S G ++LT++G     +  P     K Y V ++   T
Sbjct: 82  VVDLVGDAYPRRELFPAGRLDKTSTGFVLLTDDGGFAHDILSPRHHVSKTYTVTIDTPLT 141

Query: 119 QDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           Q+       GVTL DG  L PA    +                       +++ L +G  
Sbjct: 142 QEMCTGFAAGVTLADGTALSPAEVTALSPDGL-----------------TVRVVLRQGVY 184

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVTD 217
            Q++RM    G     L R A+G  +LD  LA G+WRE++D
Sbjct: 185 HQIKRMFGVYGAGVNALHREAIGGLALDAQLAPGQWRELSD 225


>UniRef50_Q1MQ05 Pseudouridine synthase n=1 Tax=Lawsonia intracellularis PHE/MN1-00
           RepID=Q1MQ05_LAWIP
          Length = 270

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 68/222 (30%), Positives = 102/222 (45%), Gaps = 24/222 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK----PENQPTRVILFNKPYDVLPQFTDEA 58
           +  I+  ++ +     H  K         R+     +N+    +   KP  V+    D  
Sbjct: 49  EVTINGKSVTQPGIYIHPDK--DIIALHGRRVDIQLKNKKYYYLSMYKPIKVISSVKDPQ 106

Query: 59  GRKTLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
            R T+ +FIP       +Y  GRLD  SEGLL++TN+G L  RLT P     K+Y+V + 
Sbjct: 107 NRLTVLDFIPFPWKNYRLYPVGRLDFFSEGLLLITNDGELTQRLTHPRYHISKVYHVLIR 166

Query: 115 GIPTQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
                  L+ +  G+TL+DG    PA   ++                    T+WL+ITL 
Sbjct: 167 ERILNTTLKNISKGITLSDGTKLPPAKVRVLSS-------------ITETNTTWLEITLQ 213

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           +G NRQ+RRM   +G   L+LIR   G+ +L NL  GE R +
Sbjct: 214 QGINRQIRRMCKELGLTILKLIRVKQGNINLSNLQPGEVRPL 255


>UniRef50_C2KV26 Pseudouridylate synthase n=1 Tax=Oribacterium sinus F0268
           RepID=C2KV26_9FIRM
          Length = 239

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 55/222 (24%), Positives = 102/222 (45%), Gaps = 27/222 (12%)

Query: 4   FIISENTMQKTSFRNHQVKRFS-SQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
             I+   ++  S    +V+  +            +     + NKP  VL    D   +KT
Sbjct: 27  VKINGEIVKDPS---MEVQPGNSEIVYKDEPIHYEEFSYYMMNKPVGVLSSTED-RKQKT 82

Query: 63  LKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           + +    +    ++  GRLD+DSEGLL++ N+GAL  +L  P     K Y V++ G  ++
Sbjct: 83  VLDLFSDKHRKDLFPVGRLDKDSEGLLLIMNDGALAHKLLSPKMHIEKKYLVEIPGKISE 142

Query: 120 DALEALRNGVTLN-DGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           + L+ LR G+  + D   +PA A  +                 +   S +++ + EG+  
Sbjct: 143 EELDRLRQGIQYDTDLIAMPAKARCLSS---------------TEEGSRVEVIIMEGKFH 187

Query: 179 QVRRMTAHV--GFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           Q+++M   +   +   +L R +MG   LD  LA GE+R++++
Sbjct: 188 QIKKMFLALSTDYVVTKLQRLSMGPLHLDPALAPGEYRKLSE 229


>UniRef50_P45104 Ribosomal large subunit pseudouridine synthase B n=177
           Tax=Gammaproteobacteria RepID=RLUB_HAEIN
          Length = 357

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 60/220 (27%), Positives = 86/220 (39%), Gaps = 22/220 (10%)

Query: 3   QFIISENTMQ---KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           +  +         +    +    R   Q       + +  RV+++ KP   L   +D  G
Sbjct: 101 RVSVEGKIATLGDRIDVHSGVKVRIDGQIINLSHTQKEICRVLMYYKPEGELCTRSDPEG 160

Query: 60  RKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           R T+ + +P        A GRLD ++ GLL+ T +G L  RL  P +   + Y V+V G 
Sbjct: 161 RATVFDRLPRLTGSRWIAVGRLDINTSGLLLFTTDGELANRLMHPSREVEREYSVRVFGQ 220

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
                L  LR GV L DG       +                        W  +TL EGR
Sbjct: 221 VDDAMLARLRKGVQLEDGLANFKEIKFTGGVGI---------------NQWYDVTLMEGR 265

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           NR+VRR+    G    RLIR   G+  L   L  G W E+
Sbjct: 266 NREVRRLWESQGIQVSRLIRIRYGNIKLMKGLPRGGWEEM 305


>UniRef50_A2S4Y2 Pseudouridine synthase n=7 Tax=Burkholderiales RepID=A2S4Y2_BURM9
          Length = 235

 Score =  200 bits (509), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 98/211 (46%), Positives = 132/211 (62%), Gaps = 8/211 (3%)

Query: 12  QKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI 67
            + S    ++  F+ +R  RR      E  P R+I  NKP+  + QF+    R +L +++
Sbjct: 13  TRRSVLCIKIPPFAIERGPRRAAPLPREPCPMRLIALNKPFGTICQFSAHETRASLGDWV 72

Query: 68  PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRN 127
              GVY AGRLD DSEGLL+LT++GALQA++ +P  +  K Y+ QVEG P   AL AL  
Sbjct: 73  KTPGVYPAGRLDADSEGLLLLTDDGALQAKIAEPRHKLVKRYWAQVEGAPDAAALAALER 132

Query: 128 GVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHV 187
           GV L D  + P  A  +  P  LWPRNPPIR R +IPT+W+++ + EG+NRQVRRMTA V
Sbjct: 133 GVDLGDYVSRPCRARFITPPGALWPRNPPIRHRAAIPTAWIELEIAEGKNRQVRRMTAAV 192

Query: 188 GFPTLRLIRYAMGDY---SLDNLANGEWREV 215
           GFPTLRL+R  +G     +L  LA GE RE+
Sbjct: 193 GFPTLRLVRVGIGALDVFALG-LAPGETREL 222


>UniRef50_B4RA72 Pseudouridine synthase n=4 Tax=Caulobacteraceae RepID=B4RA72_PHEZH
          Length = 521

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 64/216 (29%), Positives = 99/216 (45%), Gaps = 17/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  I+   +   +    +V+             E +P RV  ++KP  ++    D  GR 
Sbjct: 176 RVAINGQVLTTPAV---KVEPGDILTVDGAVVGEPEPVRVFRYHKPVGLVTTHKDPQGRP 232

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ E +P     + + GRLD +SEGLL+LTN+G L   L  P     + Y  +  G  TQ
Sbjct: 233 TVFEALPEGLPRLISVGRLDLNSEGLLLLTNDGGLARALELPATGVVRRYRARAHGRITQ 292

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + L+ L++G+T+         A L              +E       WL +TL EG+NR+
Sbjct: 293 ERLDTLKDGITVEGVRYGAIEARL-----------DKAKEGHQGANLWLTVTLQEGKNRE 341

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VRR+   +G    RLIR + G ++L  L  GE  EV
Sbjct: 342 VRRVLEALGLKVNRLIRLSYGPFALGTLDVGEIEEV 377


>UniRef50_Q2W4E4 Pseudouridine synthase n=20 Tax=cellular organisms
           RepID=Q2W4E4_MAGSA
          Length = 247

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 30/221 (13%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +++ T+     +          R      +  P  V++ +KP       +D    + 
Sbjct: 40  RVTLADGTVLDDGTKAAH----DDIRVDGEPLDPPPGLVLMLHKPEGYTCSTSDPG--RI 93

Query: 63  LKEFIPVQGVY------AAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           + E +P + ++        GRLDRDS GLL+LT++G L  R+T P +   K Y V +   
Sbjct: 94  VYELLPERFMHRNPIVAPVGRLDRDSTGLLLLTDDGPLAHRITSPKRHVPKTYEVTLARP 153

Query: 117 PTQDALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
            + +      +G + L    T  A AELV                        +IT+ EG
Sbjct: 154 LSGEEGAVFASGTLMLRSESTPLAPAELVVSGPQTA-----------------RITITEG 196

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R  QV+RM A VG    RL R A+G   L +LA G+WR ++
Sbjct: 197 RYHQVKRMFAAVGNHVERLHRAAIGGLDLGDLAEGQWRPLS 237


>UniRef50_D1N1S2 Pseudouridine synthase n=1 Tax=Victivallis vadensis ATCC BAA-548
           RepID=D1N1S2_9BACT
          Length = 241

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 60/218 (27%), Positives = 89/218 (40%), Gaps = 26/218 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-TRVILFNKPYDVLPQFTDEAGRK 61
           +  ++  T+ +      +V               +     I+ NKP   +    D     
Sbjct: 32  RVTVNGETVFEP---GFRVAPGDRVEYDGVPVLAEERKVYIMLNKPRGYVCTNADPHADL 88

Query: 62  TLKEFI---PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
              + I   P   +++AGRLD+DSEGL++ +N+G   ARLT P     K+Y V+V     
Sbjct: 89  KAVDLIRLTPPLRLFSAGRLDKDSEGLILFSNDGDYVARLTHPRHEILKVYQVRVRREFK 148

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
              LE +R GV                +                       ITL EG+NR
Sbjct: 149 PAELEQMRRGVLERGELLKVHAVSRCGD-------------------CTYLITLNEGKNR 189

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++RR+TA +G PT RL R  +G   L  L  G WRE+T
Sbjct: 190 EIRRLTAALGSPTRRLKRLQIGALRLGGLPVGNWRELT 227


>UniRef50_C6HYA4 Pseudouridine synthase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HYA4_9BACT
          Length = 638

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 63/217 (29%), Positives = 101/217 (46%), Gaps = 22/217 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT--RVILFNKPYDVLPQFTDEAGRK 61
             +    + +      +V           +P  +     + LF KP  V+    D  GR 
Sbjct: 52  VTVDGEVVTEP---GTRVDPKHQVILVDGRPLPREPETFLFLFYKPKGVVSTLFDPEGRP 108

Query: 62  TLKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           TL+++ P +  +   GRLD  +EG L+LTNNG L  R+  P     + Y V+++G  +  
Sbjct: 109 TLRDYFPGIDPLLHIGRLDFQTEGALLLTNNGDLSQRILHPRFEIPRTYLVKIQGGMSPA 168

Query: 121 ALEALRNG-VTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            LE +  G + L+  P +P                  + ER++   +W +ITL EGRNR+
Sbjct: 169 HLERMARGEIRLDGRPVVPLEL---------------VPERQTSTNAWYRITLTEGRNRE 213

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           VRR+   + +  L+L+R A G  +L  L  GE+R VT
Sbjct: 214 VRRLFETLNYFVLKLVRTAFGPLTLAGLEPGEYRTVT 250


>UniRef50_A5TW76 Pseudouridine synthase n=11 Tax=Fusobacterium RepID=A5TW76_FUSNP
          Length = 226

 Score =  199 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 55/224 (24%), Positives = 95/224 (42%), Gaps = 28/224 (12%)

Query: 1   MRQFIISENTMQ----KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTD 56
           +++ I ++          S +++  +          K E +  R  + NK    +    D
Sbjct: 18  VKKLISNDEITVNGFNDISAKDNIDENSDIIEYNGEKLEYKEFRYYIMNKKAGYITATED 77

Query: 57  EAGRKTLKEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQ 112
                T+ + +P     + +   GRLD+D+EGLL+ TN+G L  RL  P     K+YY++
Sbjct: 78  -FKENTVMDLLPEWVIRKDLAPVGRLDKDTEGLLLFTNDGKLNHRLLSPKNHIDKVYYIE 136

Query: 113 VEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
           +E       +  L  GV + +  T PA  E + +                   + + +T+
Sbjct: 137 IENNILDKDILKLEQGVDIGNYITQPAKVEKISD-------------------NKIYLTI 177

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            EG+  QV++M   V      L R + G   LD+LA GE +EV 
Sbjct: 178 KEGKFHQVKKMLEAVNNKVCYLKRVSFGKLKLDDLALGEVKEVN 221


>UniRef50_Q55578 Uncharacterized RNA pseudouridine synthase slr0361 n=21
           Tax=Cyanobacteria RepID=Y361_SYNY3
          Length = 249

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 73/224 (32%), Positives = 110/224 (49%), Gaps = 26/224 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPT-RVILFNKPYDVLPQFTDEAGRK 61
           +  ++         +    + F S    + K +N+P    +L NKP DVL    D  GRK
Sbjct: 28  RVSVNGKVA-NLGDKADPQQDFLSVDGKQIKADNRPRDIYLLVNKPRDVLSTCDDPRGRK 86

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ + +P      +G++  GRLDR+S G L+LTN+G L  RLT P     K Y V +EG 
Sbjct: 87  TVLDLLPQDLQRGKGLHPVGRLDRNSTGALLLTNDGELTLRLTHPRYHLPKTYDVWLEGN 146

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           P+ + LE  R+G+ L+   TLPA  E++ E                     L +TL EGR
Sbjct: 147 PSDEDLEKWRSGMMLDGKKTLPATLEVISENKDQIH---------------LLVTLTEGR 191

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDN----LANGEWREVT 216
           NRQ+RR+   +G   L+L R  +G   L      L +G++R ++
Sbjct: 192 NRQIRRLAEELGLTVLKLHRRTIGPLQLHTRGKVLGSGQFRFLS 235


>UniRef50_A0NV51 Pseudouridine synthase n=2 Tax=cellular organisms
           RepID=A0NV51_9RHOB
          Length = 520

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 99/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V          +  P  + TR+ L++KP  ++    D  GR 
Sbjct: 128 RVELNGKLLTTPAVT---VTPDDKVVVDGQPLPMRERTRLWLYHKPRGLVTTNKDPEGRP 184

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ E +P     V   GRLD ++EGLL+LTN+G L   L  P     + Y V+  G  TQ
Sbjct: 185 TVFERLPDDLPRVLTVGRLDINTEGLLLLTNDGGLARVLELPATGWLRRYRVRAFGKVTQ 244

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L++G+ +         A L               +++     W+ + L EG+NR+
Sbjct: 245 PDLDTLKDGIAIEGVLYGAIEATL---------------DKEQGNNVWMTVGLREGKNRE 289

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           V+R+  H+G    RLIR + G + L +L  G+ RE+
Sbjct: 290 VKRVLEHLGLAVNRLIRLSYGPFQLMDLPEGDVREI 325


>UniRef50_C6J9Y4 Pseudouridine synthase n=2 Tax=Clostridiales RepID=C6J9Y4_9FIRM
          Length = 323

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 54/216 (25%), Positives = 98/216 (45%), Gaps = 25/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++     K +    +V       +      +N+   ++LFNKP  ++     +    
Sbjct: 39  RITVNG----KKAESGQKVSLEDEICADNIPVHKNEKKVLLLFNKPRGIVCSTKQQFDET 94

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ +++     VY  GRLD++S+GLL+LTN G L  ++ + G    K Y+V V     ++
Sbjct: 95  TVTDYLDYPLRVYPVGRLDKESQGLLLLTNEGDLVNKIMRAGNYHEKEYFVTVNKPVDRE 154

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +  +  GV + D  T P       E +                    +I L +G NRQ+
Sbjct: 155 FVRRMSKGVPVLDTVTRPCRVVQTGECS-------------------FRIILTQGLNRQI 195

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM  ++G+   +L R  + + +LD +  GE+RE+T
Sbjct: 196 RRMCRYLGYEVQKLKRIRIMNLTLDGIREGEYREIT 231


>UniRef50_C1DA59 Pseudouridine synthase n=6 Tax=Betaproteobacteria
           RepID=C1DA59_LARHH
          Length = 703

 Score =  199 bits (507), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 25/223 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEA 58
           +  I+       +    +V+     R   +       ++  RVI+++K    +    D  
Sbjct: 478 RVSINGAV----AELGARVRPGDKVRVDSKPVLIRWPDRLPRVIVYHKQEGEIVTRDDPE 533

Query: 59  GRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
           GR T+ + +P        A GRLD ++ GLL+ T +G L  R+T P     + Y V+V G
Sbjct: 534 GRTTVFDRLPQTRSSKWVAIGRLDVNTSGLLIFTTSGDLANRMTHPSFEVEREYAVRVLG 593

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             T + ++    GV L+DGP                       +++     W ++ + EG
Sbjct: 594 KLTPEQMKETTAGVQLDDGPASFQFIR-------------EDDDKEDSVNHWYRVGIREG 640

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           RNR+VRRM  H G    RL+R   G  +L   L  G++ E+ +
Sbjct: 641 RNREVRRMFEHFGLTVSRLMRVRFGIVTLPSRLKRGQFYELNE 683


>UniRef50_Q13BM8 Pseudouridine synthase n=55 Tax=Alphaproteobacteria
           RepID=Q13BM8_RHOPS
          Length = 795

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRK-PENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V          +  PE + TR+ L++KP  ++    D  GR 
Sbjct: 501 RVAVNGRVIDSPAL---DVTYSDVITVDGKPLPERERTRLFLYHKPRGLMTTHADPEGRP 557

Query: 62  TLKEFIPV--QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     + + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G  TQ
Sbjct: 558 TVFDNLPEDLPRLISIGRLDFNTEGLLLLTNDGGLARALELPETGWLRRYRVRAHGEVTQ 617

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L +GV ++     P  A+L               ER      WL   + EG+NR+
Sbjct: 618 AQLDQLASGVEVDGVKYGPIEAKL---------------ERDQGANVWLVFAIREGKNRE 662

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VR + AH+G    RLIR + G + L  +  G+  EV
Sbjct: 663 VRNVLAHLGLEVNRLIRVSYGPFQLLEIEEGQVEEV 698


>UniRef50_Q3AI58 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=Q3AI58_SYNSC
          Length = 230

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 93/185 (50%), Positives = 114/185 (61%), Gaps = 10/185 (5%)

Query: 42  ILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           +L NKPY VL QFT E G +   L +F+ V  VYAAGRLD DSEGLL+LT+NG LQ RLT
Sbjct: 19  LLLNKPYGVLSQFTSEEGSRWRCLSDFVDVPQVYAAGRLDADSEGLLILTSNGRLQQRLT 78

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELV--DEPAWLWPRNPPI 157
            P     + Y+ QVEG P  + L+ L +GV +    TLPA A  +   +   L  R P I
Sbjct: 79  DPRFGHWRSYWAQVEGTPNTEQLQQLCDGVVVQGRRTLPAKARWLQGQDLPQLPERTPQI 138

Query: 158 RERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMG------DYSLDNLANGE 211
           R R +IPT+WL+++L EGRNRQVRRMTA VG PTLRL+R  +          L  L  G 
Sbjct: 139 RFRAAIPTNWLQLSLSEGRNRQVRRMTAAVGLPTLRLVRCCIDLMDNGPPLDLTGLQPGS 198

Query: 212 WREVT 216
           WR VT
Sbjct: 199 WRTVT 203


>UniRef50_Q6FCZ3 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q6FCZ3_ACIAD
          Length = 264

 Score =  199 bits (506), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 99/178 (55%), Positives = 125/178 (70%), Gaps = 2/178 (1%)

Query: 40  RVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++++FNKPYDVL QF +++   T+  FI    +  AGRLD DSEGL+ LT++G L   +T
Sbjct: 2   KIVVFNKPYDVLSQFREDSAHLTVSSFIADPELRIAGRLDLDSEGLMFLTDHGGLNQYIT 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRE 159
            P  +  K Y VQV+G  T+DALE LR GV L DG TLPA A  V+EP WLW RNPP+R 
Sbjct: 62  HPSNKKYKTYLVQVDGDITEDALEKLRKGVELADGLTLPAQATKVEEPEWLWERNPPVRF 121

Query: 160 RKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD--NLANGEWREV 215
           R SIPTSW++I++ EGRNRQVRRMTA VGFPTLRLIR  +G  +L    L  GE +E+
Sbjct: 122 RASIPTSWVEISICEGRNRQVRRMTATVGFPTLRLIRTQIGSINLVKLGLQPGEQKEI 179


>UniRef50_Q6F9V5 Pseudouridine synthase n=17 Tax=Acinetobacter RepID=Q6F9V5_ACIAD
          Length = 239

 Score =  198 bits (505), Expect = 8e-50,   Method: Composition-based stats.
 Identities = 57/218 (26%), Positives = 94/218 (43%), Gaps = 23/218 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             I +   +   +R H +  F+ Q   +     +    I+ NKP             +++
Sbjct: 31  VSIQDEIQKDLKYRIHDLTDFNFQVFDQNYV-YREKVYIILNKPKGFECSHQ-PHHHQSV 88

Query: 64  KEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
              +P     + + A GRLD+D+ GLL+LT++G     LT P K   K+Y+V      T 
Sbjct: 89  FSLLPDLLIQRNIAAVGRLDQDTTGLLLLTDDGQYLHTLTHPKKHVPKVYHVATIDPITV 148

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           D +  L  GV L++   + A   +                   +  + L +T+++G   Q
Sbjct: 149 DQMHQLEQGVELHNEKGVFAATNVTL-----------------LNETQLSMTIHQGVYHQ 191

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           V+RM A VG     L R+ +G   L NLA GEW  +T+
Sbjct: 192 VKRMIAAVGNKVTALHRHKIGQLELPNLAEGEWMYLTE 229


>UniRef50_B7L2Z9 Pseudouridine synthase n=4 Tax=Rhizobiales RepID=B7L2Z9_METC4
          Length = 320

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 62/204 (30%), Positives = 95/204 (46%), Gaps = 19/204 (9%)

Query: 18  NHQVKRF-SSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFI---PVQGVY 73
             +V    ++     R+  +     +L NKP  +L  + D  GRKT+ + +    +  + 
Sbjct: 62  GVRVDPQRAAICVDGRRLVSAAKVYLLLNKPRGLLTTYGDPQGRKTVYDCLAGHDLPFLA 121

Query: 74  AAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLND 133
             GRLD  SEGLL++TN+     RL  P     K+Y+VQ++  P +  L  LR GV  + 
Sbjct: 122 PVGRLDCASEGLLLMTNDTRWAHRLLDPASNVDKVYHVQIDRRPDEALLTGLREGVAHDG 181

Query: 134 GPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLR 193
                     +               R     +WL++ L EGRNRQ+RRM A  G   LR
Sbjct: 182 ERLAAKSVAPL---------------RVGERNAWLEVVLSEGRNRQIRRMMALNGAEVLR 226

Query: 194 LIRYAMGDYSLDNLANGEWREVTD 217
           L+R A+G   L ++  G +R +TD
Sbjct: 227 LVRVAVGGVRLGDVRKGAFRHLTD 250


>UniRef50_C0W3E8 Pseudouridine synthase n=1 Tax=Actinomyces urogenitalis DSM 15434
           RepID=C0W3E8_9ACTO
          Length = 325

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 59/229 (25%), Positives = 90/229 (39%), Gaps = 32/229 (13%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRV-ILFNKPYDVLPQFTDEAGRK 61
           +  +    + +   R    ++    R    +    P  + +L +KP  V+    D  GR 
Sbjct: 101 RVSVDGVVVTEPGVRVDPSRQ--EIRVDGSRVLTDPDVITVLLHKPAGVVTTMEDPQGRP 158

Query: 62  TLKEF--------------IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGK 107
           T+ +                    +   GRLD ++EGLL+L+N+G L  RL  P     K
Sbjct: 159 TVADLAEQFISEHRTELEHPESVRLVHVGRLDTETEGLLLLSNDGDLAHRLMHPSFEISK 218

Query: 108 IYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSW 167
            Y   VEG         LR G+ L+DG                      + +      S 
Sbjct: 219 TYVAIVEGQVEGWVPRKLRRGIELDDGLAQADRV---------------VVKDAGPSGSI 263

Query: 168 LKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           ++ITL+ G+NR VRRM   VG P  RL R  +G   +  L  G+ R +T
Sbjct: 264 VEITLHSGKNRIVRRMLDAVGHPVTRLARTKLGPLGIGGLRPGQMRRLT 312


>UniRef50_C9L6I1 Pseudouridine synthase n=1 Tax=Blautia hansenii DSM 20583
           RepID=C9L6I1_RUMHA
          Length = 271

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 58/216 (26%), Positives = 99/216 (45%), Gaps = 24/216 (11%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGR 60
           ++ ++      K + +  QV+ F   +   +  + +    +++F+KP  +         +
Sbjct: 25  KRVLVDG----KPAVQGMQVEDFQEIKVDGKAIKREEKKVLLVFHKPKGIECTANPNVKK 80

Query: 61  KTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
             +        VY AGRLD+DSEGLL+LTN G L  ++ + G    K Y V V+   T++
Sbjct: 81  NVISYINYPIRVYYAGRLDKDSEGLLLLTNQGELVNQIMKAGSYHEKEYLVTVDKPVTEE 140

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L+++R GV +    T     E   E                      +ITL +G NRQ+
Sbjct: 141 FLQSMREGVPVLGTITRKCKVEKESEKV-------------------FRITLTQGLNRQI 181

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RRM  ++G+  ++L R  + +  L NL  G +RE T
Sbjct: 182 RRMCNYLGYEVVKLKRIRIMNIELGNLPIGSYREAT 217


>UniRef50_B5ELL5 Pseudouridine synthase n=3 Tax=Acidithiobacillus RepID=B5ELL5_ACIF5
          Length = 268

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 90/214 (42%), Gaps = 18/214 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    +     R          R           +V+L +KP  VL    DE GR T
Sbjct: 49  RVEVDGRRILDPEARFP--LSGPGIRIDGLDITASTRQVLLLHKPRGVLTTRQDERGRAT 106

Query: 63  LKEFIP-VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + + +P    +   GRLD+ S GLL+ +N+     RL  P +   K Y+VQ+    + D 
Sbjct: 107 VYDLLPGSPWLAPVGRLDQASSGLLLFSNDPHWAQRLLDPDQHVAKTYHVQIRPPLSTDT 166

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +  L     L+  P LP     +               R    T WL+  L EGRNRQ+R
Sbjct: 167 VVQLAADSVLDGEPCLPMQIREL---------------RCGGKTQWLEFILQEGRNRQIR 211

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           R+ A      LRLIR A+G+  L  L  GEWR +
Sbjct: 212 RLLAACDREVLRLIRVAVGNLPLGELRAGEWRWL 245


>UniRef50_Q2NSN0 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q2NSN0_SODGM
          Length = 235

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 30/222 (13%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-PTRVILFNKPYDVLPQFTDEAGR 60
           ++  +    +++ +F   Q++     R            R  + NKP   +    D    
Sbjct: 25  KRVTVDGEIIKQGAF---QLRPEHQVRFDGNLLHQILTARYFMLNKPQGYVCSTDDP-DH 80

Query: 61  KTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
            T+  FI       ++AAGRLD D+ GL++LT++G    RLT P     K Y V +E   
Sbjct: 81  PTILYFIDEPVPDKLHAAGRLDIDTTGLVLLTDDGQWSYRLTSPRHHCEKDYLVTLEQPL 140

Query: 118 TQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             +       G+ L     PT PA    +                       +++T+ EG
Sbjct: 141 AAEITAQFAAGILLRGEKLPTRPARLATLSPL-------------------KVRLTISEG 181

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
           R  QV+RM A VG   + L R  +G   LD  L  GE+R +T
Sbjct: 182 RYHQVKRMFAAVGNRVVALHRERIGAIVLDAHLQPGEYRALT 223


>UniRef50_Q1H048 Pseudouridine synthase n=4 Tax=Betaproteobacteria
           RepID=Q1H048_METFK
          Length = 383

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 55/221 (24%), Positives = 87/221 (39%), Gaps = 27/221 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP----ENQPTRVILFNKPYDVLPQFTDEA 58
           +  I+  T    +     V      R   R      E +  +V+L++KP   +    D  
Sbjct: 54  RITINGKT----AEVGASVVPSDVVRLDSRPLRLPFEPELPQVLLYHKPEGEIVSHDDPE 109

Query: 59  GRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
            R ++ + +P        A GRLD ++ GLL+ T +G L  R   P     + Y V++ G
Sbjct: 110 NRASVFDKLPRIRNGKWIAIGRLDMNTSGLLIFTTSGELANRFMHPRYEVEREYAVRIFG 169

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             T+  +  L  G+ L+DGP                       +       W ++ L EG
Sbjct: 170 ELTEGEMAQLTYGIELDDGPANFDSIR---------------PQGGEGANHWYEVILREG 214

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           RNR+VRR+      P  RLIR   G  +L   L  G+   +
Sbjct: 215 RNREVRRLFEAFQKPVSRLIRVRFGPVNLPPRLKRGQMIHL 255


>UniRef50_D0SB72 Pseudouridine synthase n=5 Tax=Acinetobacter RepID=D0SB72_ACIJO
          Length = 368

 Score =  197 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 58/222 (26%), Positives = 86/222 (38%), Gaps = 28/222 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-----PTRVILFNKPYDVLPQFTDE 57
           +  ++    Q       +++     R   RK   Q       RV+++ KP   +    D 
Sbjct: 28  RVSVNGQVAQ----VGERIEPGDELRIDGRKVSFQIEDEIRRRVLIYYKPEGEICSRNDP 83

Query: 58  AGRKTLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
             R T+ + +P          GRLD +S GLL+ TN+G L  RL  P     + Y V+V 
Sbjct: 84  ESRPTVFDQLPAIANDRWVMVGRLDINSTGLLLFTNDGELANRLMHPSNEVEREYAVRVM 143

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
           G  T      +  GV L+DGP        +                      W ++ + E
Sbjct: 144 GEVTPQIKNNMLKGVVLDDGPAKFESFSEIGGEGI---------------NRWYQVVVKE 188

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           GRNR+VRR+    G    RL+R   G   L   L  G W E+
Sbjct: 189 GRNREVRRIFESQGLKVSRLLRTRYGTVILPRELRTGRWMEL 230


>UniRef50_Q9HZ55 Ribosomal large subunit pseudouridine synthase B n=67
           Tax=Gammaproteobacteria RepID=RLUB_PSEAE
          Length = 386

 Score =  197 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 57/222 (25%), Positives = 88/222 (39%), Gaps = 27/222 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQP-----TRVILFNKPYDVLPQFTDE 57
           +  ++ +     +    +V    +          +       RV+++NKP   +    D 
Sbjct: 39  RVNVNGSV----ASLGQRVDSHDAITVDGHLIRREEAAESVRRVLIYNKPEGEVCTRDDP 94

Query: 58  AGRKTLKEFIPVQG---VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
            GR T+ + +P          GRLD ++ GLL+ T +G L  RL  P     + Y V+V 
Sbjct: 95  EGRPTIFDRLPRLRTGRWINVGRLDINTTGLLLFTTDGELANRLMHPSYEMDREYAVRVR 154

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
           G  T++ +E L NGV L DGP   +  +                        W    + E
Sbjct: 155 GEVTEEMIERLLNGVMLEDGPAKFSDIQQAPGGEGF--------------NHWYHCVVME 200

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           GRNR+VRR+    G    RL R   G   L   L  G +RE+
Sbjct: 201 GRNREVRRLWESQGLVVSRLKRVRFGPVFLTSELTMGRYREM 242


>UniRef50_C9RMB6 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RMB6_FIBSS
          Length = 286

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 59/243 (24%), Positives = 90/243 (37%), Gaps = 40/243 (16%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +    ++         +         +  +       + NKP   +   +DE GR T
Sbjct: 53  RVSLRGKIVRDPDT---PARENDEICVDGKPVKASEFVYFMMNKPRGYVTTASDEKGRAT 109

Query: 63  LKEFI-----------PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKR------- 104
           + +             PV  +   GRLD  SEGLL+ TN+      L +           
Sbjct: 110 VMDLFREQYAKMFPGKPVPHISPVGRLDAASEGLLLFTNDTQWADALLKTKDERRKTRDD 169

Query: 105 -----------TGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPR 153
                        KIY VQV G PT + L  +  G  +           +  EP      
Sbjct: 170 KCVERESRGPIHTKIYRVQVNGHPTAEELSQMEAGFNVPP--------RVFGEPEEFMHA 221

Query: 154 NPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWR 213
                        WL+ITL EG+NR++RRM A +G+  LRL+R    +Y L +L  GE R
Sbjct: 222 VSAKLYSAGEKNCWLEITLDEGKNREIRRMLAKLGYEVLRLVRIKFCNYELGDLKQGEIR 281

Query: 214 EVT 216
           ++ 
Sbjct: 282 KIN 284


>UniRef50_A1U6Q2 Pseudouridine synthase n=4 Tax=Gammaproteobacteria
           RepID=A1U6Q2_MARAV
          Length = 231

 Score =  197 bits (501), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 63/220 (28%), Positives = 95/220 (43%), Gaps = 29/220 (13%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  +   T ++    N QV+   S     +         ++ +KP  VL   TD   + T
Sbjct: 26  RVKVDGETCRQ---ANRQVEAEQSVHLDGKPVNPPGDIYLMMHKPAGVLSATTDS-SQPT 81

Query: 63  LKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
             + +P      V+ AGRLD+D+ GLL+LT++G     +T P +   K Y V +     +
Sbjct: 82  ALDLLPRGLASRVHIAGRLDKDTTGLLLLTSDGQWSHAVTSPRRECRKSYRVWLAEAIPE 141

Query: 120 DALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
            A  AL  GV LN     T PA   +                        + +T+ EGR 
Sbjct: 142 QACRALEKGVMLNGETTETRPAEVRV-------------------HNNQLIDLTIGEGRY 182

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
            QV+RM A VG     L R+ +G   LD+ LA GE+R +T
Sbjct: 183 HQVKRMLAAVGNRVEALHRFRIGSIELDDKLAPGEFRALT 222


>UniRef50_B5INL2 Ribosomal large subunit pseudouridine synthase E n=1 Tax=Cyanobium
           sp. PCC 7001 RepID=B5INL2_9CHRO
          Length = 243

 Score =  197 bits (501), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 99/197 (50%), Positives = 120/197 (60%), Gaps = 11/197 (5%)

Query: 30  TRRKPENQPTRVILFNKPYDVLPQFTDEAGRK--TLKEFIPVQGVYAAGRLDRDSEGLLV 87
              +        +LF+KPY VL QFT E G +   L +FI V GVYAAGRLD DSEGLL+
Sbjct: 4   GPEELPASRPTTLLFHKPYGVLSQFTPEPGSRWRCLADFIAVPGVYAAGRLDADSEGLLL 63

Query: 88  LTNNGALQARLTQPGKRTGKIYYVQVEGIP--TQDALEALRNGVTLNDGPTLPAGAELVD 145
           LT NG LQ RLT P     + Y+VQVEG      +AL+ LR GV +    T PA    + 
Sbjct: 64  LTANGRLQQRLTDPAFGHWRTYWVQVEGEAGQRPEALQQLRQGVVIQGRLTRPALVRCLS 123

Query: 146 EPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAM------ 199
           +P  L  R+PPIR+R +IP SWL++ L EGRNRQVRRMTA VG PTLRLIR A+      
Sbjct: 124 DP-KLPERDPPIRQRATIPVSWLELQLQEGRNRQVRRMTARVGLPTLRLIRVAIDLMDGE 182

Query: 200 GDYSLDNLANGEWREVT 216
              SL  L  G+WR V+
Sbjct: 183 APLSLSGLKPGDWRRVS 199


>UniRef50_C9LMR9 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LMR9_9FIRM
          Length = 239

 Score =  197 bits (501), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 55/195 (28%), Positives = 93/195 (47%), Gaps = 16/195 (8%)

Query: 24  FSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPV--QGVYAAGRLDRD 81
                +     + +P R  LF+KP  V+   +D AGR+T+ ++     + V+  GRLD  
Sbjct: 47  TDKIEALGEIVKPEPLRYYLFHKPDCVITSVSDPAGRRTVMDYFRRVRERVFPVGRLDYH 106

Query: 82  SEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGA 141
           SEGLL++TN+G L   LT P     K Y V V G  ++   + +  GV ++ G T P   
Sbjct: 107 SEGLLLVTNDGQLDFILTHPCHEVQKEYEVVVRGKFSEKLAKKMEKGVKIDSGVTAPCEI 166

Query: 142 ELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 201
           E++                     + L++ L+EG+NR++R+M     +P   L R     
Sbjct: 167 EVLG-------------YDAEKNKTRLRMVLHEGKNREIRKMMEIFHYPVFELKRIRYSF 213

Query: 202 YSLDNLANGEWREVT 216
            +L ++  G++R +T
Sbjct: 214 LTL-DVNRGQYRRLT 227


>UniRef50_C7NBL1 Pseudouridine synthase n=3 Tax=Leptotrichia RepID=C7NBL1_LEPBD
          Length = 252

 Score =  196 bits (500), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 10/222 (4%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           ++  ++   ++      H  +     +   +    +P   I+ NKP  V+    D    K
Sbjct: 25  KKVSVNNVFVKDGK--IHVDEEKDIVKYENKIINYKPFVYIMMNKPAGVISATEDSH-HK 81

Query: 62  TLKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + +  +     ++  GRLD D+EGL++LTN+G L   L  P K   K YYV++    
Sbjct: 82  TVIDLLNDEYRTYDIFPVGRLDIDTEGLILLTNDGILSHNLLSPKKHVDKKYYVKITKSL 141

Query: 118 TQDALEALRNGVTL-NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSW-LKITLYEG 175
           ++D ++ L NG+ L  +  T  A  E++   +     +    E ++      + IT+ EG
Sbjct: 142 SEDDIKTLENGIKLEENFITKNAKVEIICNNSEKESEDFDFGENENNKNENSVYITISEG 201

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMG-DYSLDNLANGEWREVT 216
           +  QV+RM   VG   L L R  MG     +NL  G +RE+T
Sbjct: 202 KFHQVKRMFKAVGNEVLYLKRVKMGNLLLDENLELGGYRELT 243


>UniRef50_O32068 Uncharacterized RNA pseudouridine synthase ytzG n=68 Tax=Bacteria
           RepID=YTZG_BACSU
          Length = 239

 Score =  196 bits (500), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 59/216 (27%), Positives = 96/216 (44%), Gaps = 24/216 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
            +I     +      H               + +    ++ NKP  VL    D   ++T+
Sbjct: 27  VMIDGKPAKDVKE--HVDPDTQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSR-QQTV 83

Query: 64  KEFIPVQGV----YAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            + +  + +    + AGRLD+D+EG L+LTN+G L  RL  P K   K Y V ++   ++
Sbjct: 84  VDLLTPEEMRFEPFPAGRLDKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISR 143

Query: 120 DALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           + +  L  GV +  G  T PA AE+    +                 + + +T+ EG+  
Sbjct: 144 EDISDLETGVYIEGGYKTKPAKAEIKTNDSG---------------NTVIYLTITEGKYH 188

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWR 213
           QV++M   VG   + L R +MG  SLD  LA GE+R
Sbjct: 189 QVKQMAKAVGNEVVYLKRLSMGRVSLDPALAPGEYR 224


>UniRef50_B2HUK5 Pseudouridine synthase n=9 Tax=Gammaproteobacteria
           RepID=B2HUK5_ACIBC
          Length = 307

 Score =  196 bits (499), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 59/222 (26%), Positives = 88/222 (39%), Gaps = 28/222 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQ-----PTRVILFNKPYDVLPQFTDE 57
           +  ++    Q       +++     R   RK + Q       RV+++ KP   +    D 
Sbjct: 28  RVSVNGRIAQ----VGERIEPGDELRIDGRKVQFQIEDEIRRRVLIYYKPEGEICSRNDP 83

Query: 58  AGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
             R T+ + +P          GRLD +S GLL+ TN+G L  RL  P     + Y V+V 
Sbjct: 84  EKRPTVFDHLPQIANDRWVMVGRLDINSTGLLLFTNDGELANRLMHPSNEIEREYAVRVM 143

Query: 115 GIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYE 174
           G  T    + + NGV L DGP        +                      W ++ + E
Sbjct: 144 GEVTPQLRQNMVNGVELEDGPAKFESFSEIGGEGI---------------NRWYQVVVKE 188

Query: 175 GRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREV 215
           GRNR+VRR+    G    RL+R   G   L   L  G W E+
Sbjct: 189 GRNREVRRIFESQGLKVSRLLRTRYGTVILPRELRTGRWMEL 230


>UniRef50_Q7VBH8 Pseudouridine synthase n=1 Tax=Prochlorococcus marinus
           RepID=Q7VBH8_PROMA
          Length = 237

 Score =  196 bits (499), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 19/219 (8%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           ++  I+         +   +               + ++VIL NKP  V+    D  GRK
Sbjct: 27  KRVFINNEIA-SLGEKADILIDIIRIDDYIIPKNIKSSKVILLNKPTGVISTCRDTHGRK 85

Query: 62  TLKEFIP---VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+ + +P    +G++  GRLD+DS G L+++NNG L   LT P     K Y V + G+P+
Sbjct: 86  TVLDLLPDNLQKGMHPVGRLDKDSRGALIISNNGLLTLHLTHPRFNHKKRYSVLITGVPS 145

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
           ++ L+  RNG+ ++   T  A   +V               ++    + L+I L+EGRNR
Sbjct: 146 KNTLKKWRNGIEIDKKTTRKALVNIV---------------KRQGNNTLLEIVLFEGRNR 190

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           Q+R++   +G P + LIR  +G+  L+ L  G WRE+ +
Sbjct: 191 QIRKVADKLGHPVIDLIRIEIGNIKLNGLKEGAWREINE 229


>UniRef50_A3UFV9 Pseudouridine synthase n=1 Tax=Oceanicaulis alexandrii HTCC2633
           RepID=A3UFV9_9RHOB
          Length = 354

 Score =  196 bits (499), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 60/212 (28%), Positives = 97/212 (45%), Gaps = 21/212 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   ++  +F+          R       +  PTRV  ++KP  +L   +D  GR 
Sbjct: 42  RVSVNGEILRTPAFKVMA---GDDVRVDGESIGQRPPTRVWRYHKPVGLLTTHSDPQGRD 98

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P     V + GRLD +SEGLL+LTN+G L   L  P     + Y V+  G  + 
Sbjct: 99  TVFQTLPQDMGRVISVGRLDLNSEGLLLLTNDGELARVLELPSTGWTRRYRVRAYGNASD 158

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
            AL  L NG  ++     P    +               +R++    WL + + EG+NR+
Sbjct: 159 KALAELENGTVVDGVVYGPVEVTV---------------DRRTGANVWLTVGIKEGKNRE 203

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGE 211
           VR++   VG    RL+R A G + L +L  GE
Sbjct: 204 VRKVLQSVGLTVNRLMRVAYGPFQLGSLKRGE 235


>UniRef50_B2ULL1 Pseudouridine synthase n=4 Tax=Bacteria RepID=B2ULL1_AKKM8
          Length = 188

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 89/177 (50%), Positives = 115/177 (64%), Gaps = 2/177 (1%)

Query: 41  VILFNKPYDVLPQFTDEA-GRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLT 99
           ++ FNKPY +L QFT EA   +TL EF    GVY  GRLD DSEGLL+L++   L  RL 
Sbjct: 2   ILAFNKPYGILSQFTKEAPHHRTLAEFGFPPGVYPVGRLDADSEGLLLLSDEKGLADRLL 61

Query: 100 QPGKRTGKIYYVQVEGIPTQDALEALR-NGVTLNDGPTLPAGAELVDEPAWLWPRNPPIR 158
            P  R  + Y+ QVEG P++  L  L   G+ +    TLP  A L+     + PR PP+R
Sbjct: 62  NPSGRHPRTYWSQVEGTPSETDLRPLELGGLRIRGHCTLPCRARLMRREPDVPPRIPPVR 121

Query: 159 ERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
            R SIPTSWL++TL EG+NRQVRRMTA +GFPTLRL+R  +G++SL  L  G W+E+
Sbjct: 122 YRASIPTSWLELTLVEGKNRQVRRMTAAIGFPTLRLLRARIGNFSLAGLKPGAWKEL 178


>UniRef50_Q1Q1Q0 Pseudouridine synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q1Q0_9BACT
          Length = 260

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 58/218 (26%), Positives = 96/218 (44%), Gaps = 21/218 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRS-TRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  +    +         V    S           +     L NKP D L    DE  R 
Sbjct: 28  RVTVDGERVT---ALGATVDAGKSVIYCDGMPIRPEAKIYYLLNKPKDCLCTNYDELNRL 84

Query: 62  TLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
              + I    Q +Y  GRLD+ SEGL+++TN+G L  +L+ P     K Y+++++G  + 
Sbjct: 85  RAIDIIKNVKQRLYTIGRLDKQSEGLIIITNDGELSNKLSHPKYEVNKTYFIEIDGYLSN 144

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           + + AL++GV L  G T P   + +                +S   S  ++ L EG+NR+
Sbjct: 145 ETITALQSGVWLAFGKTQPVRIKKM---------------HRSFKKSRFEMILCEGKNRE 189

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +RRM A  G     L R  +G     +L  G++R++T+
Sbjct: 190 IRRMLADHGHKVRTLRRIKIGSLCDPDLKVGKYRKLTE 227


>UniRef50_B8ETE9 Pseudouridine synthase n=1 Tax=Methylocella silvestris BL2
           RepID=B8ETE9_METSB
          Length = 676

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 24/219 (10%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V              E   TR+ LF+KP  ++    D  GR 
Sbjct: 50  RVALNGAILISPAIN---VGPDDVILIDGAPLAERARTRLFLFHKPRGLVTTEHDPEGRP 106

Query: 62  TLKEFIPV-----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           T+ +++         + + GRLD ++EGLL+LTN+G L   L  P     + Y V+ +G 
Sbjct: 107 TVFDYVREHSPEAPRLVSIGRLDINTEGLLLLTNDGGLARVLELPATGWARRYRVRAKGS 166

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
             Q  L+ LR GVT+                     +     +R      WL ++L EG+
Sbjct: 167 IDQPTLDRLRQGVTVEGVDY---------------AQIEATLDRIQGANCWLTMSLREGK 211

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           NR+++R+  H+G    RLIR + G + L +L  G+  EV
Sbjct: 212 NREIKRVLEHLGLEVNRLIRLSYGPFQLADLEEGKVEEV 250


>UniRef50_Q3IC94 Pseudouridine synthase n=6 Tax=Bacteria RepID=Q3IC94_PSEHT
          Length = 327

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 49/216 (22%), Positives = 83/216 (38%), Gaps = 24/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRK 61
           +  ++            +V          +  +  P R  I +NKP  +      +    
Sbjct: 30  RVTVNG----IRPEMGVKVSSTDVVLVDGKTLKAIPKRVYIAYNKPVGITCTTERKIQSN 85

Query: 62  TLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
            +K       ++  GRLDR SEGL+ LTN G +  ++ + G    K Y V V+    +  
Sbjct: 86  IVKAVNYPDRIFPIGRLDRPSEGLIFLTNEGDIVNKILRAGNNHEKEYVVTVDKPLNRQF 145

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +  + NGV + D  T                                 I L +G NRQ+R
Sbjct: 146 VAKMGNGVPILDTITKKCKVT-------------------QTGAQQFTIILTQGLNRQIR 186

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           RM  ++G+  + L R  + + +L  L  G+WR +T+
Sbjct: 187 RMCEYLGYEVVTLKRVRIMNVTLKGLKVGQWRHLTE 222


>UniRef50_Q14P18 Pseudouridine synthase n=2 Tax=Mollicutes RepID=Q14P18_SPICI
          Length = 267

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 53/220 (24%), Positives = 91/220 (41%), Gaps = 18/220 (8%)

Query: 2   RQFIISENTMQKTSF---RNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEA 58
            + II                +V +     +     EN     ++ NK  + +    D  
Sbjct: 20  EELIIQGRVKVNNVVVTTLGTKVGKNDQINNQILMNENSNKIYLMLNKRRNCVSTMYDPQ 79

Query: 59  GRKTLKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
            RKT+  ++    + +Y  GRLD D+ GLL+LTN+G     +T P     K Y+V + G 
Sbjct: 80  HRKTVLTYVKGISERIYPVGRLDYDTSGLLLLTNDGEFTNIITHPSHIINKTYHVLLSGY 139

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
            ++  L+ L  G+ +  G                  +   ++  +    S L +T++E  
Sbjct: 140 LSKQQLQQLATGIEIEPGIIR------------SQAQAKLVKYEEVKNVSILLLTIHEVT 187

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREV 215
             QV++M   +G   ++L R A+G   LD  L  GEWR +
Sbjct: 188 KHQVKKMIQSLGHEVIKLKRIAIGFLQLDETLKPGEWRYL 227


>UniRef50_C5SKU3 Pseudouridine synthase n=2 Tax=Asticcacaulis excentricus CB 48
           RepID=C5SKU3_9CAUL
          Length = 489

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 62/216 (28%), Positives = 103/216 (47%), Gaps = 16/216 (7%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +   +     V          +   + +PTRV  ++KP  ++    D  GR 
Sbjct: 71  KIAVNGRLLDTPATT---VSPDDLITVEGKPIRKAEPTRVWRYHKPVGLMTTHQDPQGRP 127

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+   +P +   V + GRLD +SEGLL+LTN+G L   L  P     ++Y V+  G  TQ
Sbjct: 128 TVFNSLPQELPRVISVGRLDINSEGLLLLTNDGELARALELPTTGWTRVYRVRALGRTTQ 187

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
           +AL+ L+ GVT+      P  A+L          +    +       W+ ++L EG+NR+
Sbjct: 188 EALDTLKTGVTVEGVQYGPIEAKL----------DKAQEKADGRANLWITVSLNEGKNRE 237

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           VR++   +G    RLIR A G + L ++  GE  E+
Sbjct: 238 VRKVLDSLGLKVNRLIRLAYGPFQLGDIEPGEVEEI 273


>UniRef50_Q31GA0 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q31GA0_THICR
          Length = 317

 Score =  195 bits (497), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 66/219 (30%), Positives = 100/219 (45%), Gaps = 19/219 (8%)

Query: 4   FIISENTMQ--KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
             ++         +F    +K    Q     + E QPT+VIL+NKP   +    DE GR+
Sbjct: 44  VKVNGKVATLGDRAFPTDTLKVND-QLVKETRLEKQPTQVILYNKPEGQVCSRKDEKGRE 102

Query: 62  TLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           T+   +P        + GRLD ++ GLL+LTNNG L  RL  P     + Y V+V G  +
Sbjct: 103 TIFTSLPRIINSRWISVGRLDINTSGLLILTNNGELANRLMHPSYEMEREYSVRVFGEVS 162

Query: 119 QDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
            + L+ L+ GV L DG         + +            + +     W ++ + EGRNR
Sbjct: 163 DEILDRLKKGVKLEDGFAKFESIGKIPQ------------QEEDSINQWYRVVIKEGRNR 210

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
           +VRR+    G    RL+R   G +SL  NL  G+   +T
Sbjct: 211 EVRRIWESQGVQVSRLVRTRYGQFSLPRNLRRGKSEPLT 249


>UniRef50_Q8X4Q8 Ribosomal large subunit pseudouridine synthase B n=117 Tax=Bacteria
           RepID=RLUB_ECO57
          Length = 290

 Score =  195 bits (497), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 63/220 (28%), Positives = 86/220 (39%), Gaps = 22/220 (10%)

Query: 3   QFIISENTMQ---KTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           +  +     +   +         R      + R+   Q  RV+ + KP   L    D  G
Sbjct: 28  RVSVDGKIAKLGDRVEVTPGLKIRIDGHLISVRESAEQICRVLAYYKPEGELCTRNDPEG 87

Query: 60  RKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
           R T+ + +P        A GRLD ++ GLL+ T +G L  RL  P +   + Y V+V G 
Sbjct: 88  RPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQ 147

Query: 117 PTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
                L  L  GV L DGP      +                        W  +TL EGR
Sbjct: 148 VDDAKLRDLSRGVQLEDGPAAFKTIKF---------------SGGEGINQWYNVTLTEGR 192

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
           NR+VRR+   VG    RLIR   GD  L   L  G W E+
Sbjct: 193 NREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTEL 232


>UniRef50_A5WGV6 Pseudouridine synthase n=7 Tax=Moraxellaceae RepID=A5WGV6_PSYWF
          Length = 345

 Score =  195 bits (496), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 61/226 (26%), Positives = 92/226 (40%), Gaps = 26/226 (11%)

Query: 1   MRQFIISENT--MQKTSFRNHQVKRFSSQRSTRRKPENQ-----PTRVILFNKPYDVLPQ 53
           M + I +      QK +    +V++    R   R  + +       RV+ + KP   +  
Sbjct: 60  MEEVIKAGRVSINQKPASIGDRVEQGDEIRVDGRLIKYKSEREKRRRVLAYYKPEGEICS 119

Query: 54  FTDEAGRKTLKEFIPV---QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYY 110
             D  GR T+ E +P          GRLD +S GLL+ TN+G L  RL  P     + Y 
Sbjct: 120 ANDPEGRTTVFERLPKLTHDRWIMVGRLDINSTGLLLFTNDGELAHRLMHPSNEIVREYA 179

Query: 111 VQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKI 170
           V++ G  T + +  L +GV L DG       +               +        W  +
Sbjct: 180 VRILGELTPEMMRNLTDGVMLEDGLAKFEDIK---------------QGGGEGVNKWYHV 224

Query: 171 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREV 215
            L EGRNR+VRR+    G    RL+R + G   L   L  G + E+
Sbjct: 225 KLKEGRNREVRRLIESQGLKVSRLLRTSYGSVDLPKELRTGRFIEL 270


>UniRef50_B9JSE7 Ribosomal large subunit pseudouridine synthase B n=4
           Tax=Alphaproteobacteria RepID=B9JSE7_AGRVS
          Length = 704

 Score =  195 bits (496), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 50/216 (23%), Positives = 93/216 (43%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++   +                          + TR+ L++KP  ++   +D  GR 
Sbjct: 108 RVAVNGKVLDSP---VLNATLADRIEVDGEPIRGIERTRLWLYHKPSGLVTTNSDPEGRP 164

Query: 62  TLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
           T+ + +P +   V + GRLD ++EGLL+LTN+G L   L  P     + Y V+  G   Q
Sbjct: 165 TVFDNLPEELPRVMSIGRLDINTEGLLLLTNDGGLARVLELPTTGWLRRYRVRAYGEIDQ 224

Query: 120 DALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQ 179
             L+ L++G+ ++                        + +R      W+ + L EG+NR+
Sbjct: 225 AKLDTLKDGIAVDGVLY---------------GAIDAVLDRSQGHNVWITMGLREGKNRE 269

Query: 180 VRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           ++ +   +G    RLIR + G + L +L   + +EV
Sbjct: 270 IKNVLGALGLEVNRLIRISYGPFQLGDLPESQVQEV 305


>UniRef50_C0EB54 Pseudouridine synthase n=1 Tax=Clostridium methylpentosum DSM 5476
           RepID=C0EB54_9CLOT
          Length = 248

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 54/220 (24%), Positives = 96/220 (43%), Gaps = 25/220 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           + +++   ++    +          R   R    Q    ++ NKP  V+    D+  R T
Sbjct: 28  RVLVNGTPVKAADLKV--DPEGDEIRVDGRVYGYQEHLYLMLNKPQGVVSATDDKVHR-T 84

Query: 63  LKEFIPVQ----GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + +P +    G++ AGRLDRD+ G +++T++G     +  P     K Y   ++G   
Sbjct: 85  VLDLVPPELRRRGLFPAGRLDRDTVGFVLITDDGEFAHNILSPRHHVPKTYEAGLDGPIG 144

Query: 119 QDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           ++ L  L  GV L DG    PA   ++                +S     ++I + EGR 
Sbjct: 145 ENELSVLAQGVVLGDGTKCRPAELTVL----------------QSGERPLIQIVIVEGRY 188

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            Q++RM A VG   L L R  +G  +LD +L  G+   ++
Sbjct: 189 HQIKRMFAAVGRRVLTLKRTKIGGLALDPSLKEGDCIAIS 228


>UniRef50_C6VP86 Pseudouridine synthase n=4 Tax=Lactobacillaceae RepID=C6VP86_LACPJ
          Length = 246

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 59/220 (26%), Positives = 95/220 (43%), Gaps = 22/220 (10%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
              +   +     + +      +      +   Q     + NKP  V+   TD A  KT+
Sbjct: 27  ITANGEPVISGKQQINPGS--DTVFLDDVQVRYQQYFYYVMNKPVGVITATTDSAA-KTV 83

Query: 64  KEFIP----VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            +          ++  GRLD+D+EG+LV+TN+GAL   L  P     K+Y  +V G  T 
Sbjct: 84  MDLFNTTDFRDDLFPVGRLDKDTEGILVITNDGALSHDLLSPNHHVTKVYEAEVTGEITA 143

Query: 120 DALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNR 178
             L    +G+TL DG    PA AE+V             +  +    + ++I ++EG+  
Sbjct: 144 AQLANFNDGITLKDGTELQPAQAEIV-------------QFHEIENFTTIRIMIHEGKYH 190

Query: 179 QVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
           QV+RM   +G   + L R   G  +L   L  G +R +TD
Sbjct: 191 QVKRMVGTLGERVVGLRRIKFGSLTLPVGLLAGNYRALTD 230


>UniRef50_Q1RJR2 Uncharacterized RNA pseudouridine synthase RBE_0321 n=15
           Tax=Rickettsia RepID=Y321_RICBR
          Length = 229

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 105/216 (48%), Gaps = 21/216 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           Q  ++   +   +     V   +    +     + Q +R+ ++ KP  ++    D   RK
Sbjct: 27  QVKVNGIIVTSPATN---VDTDNQVEVSGSLITSSQKSRLWIYYKPVGLITTHKDPLSRK 83

Query: 62  TLKE-FIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ E    +  V + GRLD +SEGLL+LTNNG L  +   P  +  ++Y+V+  G P   
Sbjct: 84  TVFEQLTGLPRVISIGRLDLNSEGLLLLTNNGDLARQFELPSSKLKRVYHVRAYGNPDP- 142

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L++    + ++     P   +L+               RK+   SWL++ L+EG+NR++
Sbjct: 143 LLKSNYKNLEIDGIFYNPQSIKLL---------------RKNSTNSWLEVILFEGKNREI 187

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RR+  H G    +LIR   GD+ LDNL   E+REVT
Sbjct: 188 RRIFEHFGLKVNKLIRTEYGDFKLDNLKPNEYREVT 223


>UniRef50_A9AXM1 Pseudouridine synthase n=3 Tax=Bacteria RepID=A9AXM1_HERA2
          Length = 728

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 19/216 (8%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPEN-QPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++    ++   +    K     R    +         +L +KP  V+    D  GR+
Sbjct: 27  RVSVNGRVQRELGTQIDPDK--DDIRVDGEQITPPTELHYVLLHKPSSVMTTLHDPEGRQ 84

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T+ + +     ++  GRLD DSEGLL+LT++G L  RLT P     K Y   +   P+ +
Sbjct: 85  TVADLVKSHNRLFPVGRLDYDSEGLLLLTDDGDLTFRLTHPSFEVEKEYQALLNQTPSVE 144

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L   RNGV L+DG T PA  EL++E               +   +W+++ ++EGRNRQ+
Sbjct: 145 QLREWRNGVELDDGKTAPAWIELLNE---------------TADGTWVRVVIHEGRNRQI 189

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RR+   +G    RLIR   G  +L  L  G+WR +T
Sbjct: 190 RRVAEALGLEVRRLIRLREGPLTLGELQAGQWRALT 225


>UniRef50_A0PYR9 Pseudouridine synthase n=9 Tax=Clostridium RepID=A0PYR9_CLONN
          Length = 229

 Score =  194 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 50/216 (23%), Positives = 93/216 (43%), Gaps = 25/216 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           + I++     K       V+         ++ + +    IL NKP  +    + +  +  
Sbjct: 26  RIIVNG----KLCIPGQWVEESDEILLDNKRIKPKKKVYILLNKPVGITCTSSKD-IKAN 80

Query: 63  LKEFIPVQG-VYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDA 121
           + +F+  +  ++  GRLD+ SEGL++LTN+G L  ++ +      K Y V+V+     + 
Sbjct: 81  IIDFVNYRDYIFPVGRLDKKSEGLIILTNDGELSNKILESENMHEKEYVVKVDKPFDDEF 140

Query: 122 LEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVR 181
           +E +  GV L    T       +DE                      KI L +G NRQ+R
Sbjct: 141 IENMSKGVQLKGVKTRTCIVRRIDE-------------------CTFKIILTQGLNRQIR 181

Query: 182 RMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           +MT   G+  ++L R  + +  +D +  G +R  T+
Sbjct: 182 KMTRAFGYTVVKLKRIRIMNLKIDGIDIGSFRHFTE 217


>UniRef50_D2RB61 Pseudouridylate synthase n=2 Tax=Gardnerella vaginalis
           RepID=D2RB61_GARVA
          Length = 284

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 23/223 (10%)

Query: 2   RQFIISENTMQK---TSFRNHQVKRF-SSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTD 56
            + I+           +    +V       R    + + N     +  +KP  VL    D
Sbjct: 64  EEIILDGRVEVDDELVTTLGTRVDPKRQKVRVDGSRVKFNTKLVTLALHKPKRVLSAMDD 123

Query: 57  EAGRKTLKEFI--PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
             GR TL++ +    + ++  GRLD DSEGL+++TN+G L   +  P     K Y   VE
Sbjct: 124 PKGRFTLRDIVGDKYERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATVE 183

Query: 115 GIPTQDALEAL-RNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
           G         L   GV L DG        ++D               ++  T+ +KI L+
Sbjct: 184 GKINGMVCRRLVSQGVNLEDGWIKLDRCAIID---------------QNHDTTMVKIVLH 228

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            G+NR VRR+   VGFP  RL+R  +G   L +L  G +R ++
Sbjct: 229 SGKNRIVRRIFGAVGFPVKRLVRTQIGPIKLGDLKAGSYRVLS 271


>UniRef50_B0B8U9 Pseudouridine synthase n=10 Tax=Chlamydiales RepID=B0B8U9_CHLT2
          Length = 241

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 45/217 (20%), Positives = 81/217 (37%), Gaps = 24/217 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEA-GRKT 62
             ++            +   F S     ++   +     + +KP   L     +  G K 
Sbjct: 30  VTVNGRVATGPFVTVDE--EFDSVEVGGQRIGAEKKVYFMVHKPLGYLCSSERKFPGSKL 87

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + + +      ++  GRLD+++ GL+++TN+G    R+  P     K Y ++V    T  
Sbjct: 88  VIDLLSHCPYRLFTVGRLDKETSGLILVTNDGEFANRVIHPSFGITKEYLLKVSRDVTAR 147

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            LE L  G  ++     P   + V                       +KI + EG+  ++
Sbjct: 148 DLETLMAGTVIDGKVVRPVSVKKVRRG-------------------TIKIIVNEGKKHEI 188

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R      G   L L R  +G   L  L  G++RE+TD
Sbjct: 189 RLFAEAAGLQLLELKRIRIGSLVLGGLPYGKYRELTD 225


>UniRef50_A6WK95 Pseudouridine synthase n=12 Tax=Gammaproteobacteria
           RepID=A6WK95_SHEB8
          Length = 256

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 56/225 (24%), Positives = 96/225 (42%), Gaps = 29/225 (12%)

Query: 1   MRQFIISENTMQK---TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDE 57
           +R+ ++S             + QV  FS  +      +      ++ +KP  V+    D 
Sbjct: 44  VRELLLSGRVRVDGLIVKDMDRQVDEFSHIQLDEHILQANAPVYVMLHKPIGVVSATKDI 103

Query: 58  AGRKTLKEFIPVQ---GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVE 114
              KT+ + +  +    ++ AGRLD +S GLL+LTN+      L  P  +  K+Y V + 
Sbjct: 104 Q-HKTVIDLLDCEARDELHIAGRLDLNSSGLLLLTNDSRWSDALMSPTHKVDKVYRVTLA 162

Query: 115 GIPTQDALEALRNGVT--LNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITL 172
              T++ + A   G+     D  T PA   ++ +                      ++TL
Sbjct: 163 NPITEEYIAAFAEGMYFGFEDITTQPAKLVILADNVA-------------------EVTL 203

Query: 173 YEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREVT 216
           +EG+  Q++RM      P + L R ++GD  LD  LA GE R +T
Sbjct: 204 HEGKYHQIKRMFGRFRNPVVGLHRLSIGDIVLDEKLAPGESRALT 248


>UniRef50_Q21JF0 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q21JF0_SACD2
          Length = 242

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 64/238 (26%), Positives = 101/238 (42%), Gaps = 41/238 (17%)

Query: 1   MRQFIISENTMQK---TSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDE 57
           +++ I ++        T+  +  V   ++ R      E      I+ NKP   +    D 
Sbjct: 18  VKRLIKNKTVCVDKKITTDPSFTVTNLNTVRIDGEIIEAIKPLYIMLNKPTGYVCANKDN 77

Query: 58  AGRKTLKEFIPVQG---------------VYAAGRLDRDSEGLLVLTNNGALQARLTQPG 102
                + + I  Q                +  AGRLD D+ GL++LT+NG    R+T P 
Sbjct: 78  IHSP-VVDLITEQHARQSDQTPPKYRAQSLQIAGRLDVDTTGLVLLTDNGEWNHRVTSPN 136

Query: 103 KRTGKIYYVQVEGIPTQDALEALRNGVTLNDGP--TLPAGAELVDEPAWLWPRNPPIRER 160
           K   K Y V++E      A++ L  GV L+     TLPA  EL+                
Sbjct: 137 KACFKRYRVKLEKPLDDAAIKLLSEGVMLHGEKAATLPATVELIS--------------- 181

Query: 161 KSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVTD 217
                + + +++ EGR  QV+RM   VG   ++L R A+G   LD NL  G+WR +T+
Sbjct: 182 ----NTEVLLSIQEGRFHQVKRMFVKVGTCVVKLHREAIGAIELDTNLKPGQWRHLTN 235


>UniRef50_Q15Q67 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q15Q67_PSEA6
          Length = 241

 Score =  194 bits (494), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 54/219 (24%), Positives = 93/219 (42%), Gaps = 32/219 (14%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           ++  +     +  + +       ++ R      +     +++ NKP   +    +  G +
Sbjct: 38  KRVTVKGEFAKSPALKVDP----ATVRVDGEALDAPDGILVMLNKPLGYVCSHDNNEGMR 93

Query: 62  TLKEFIP------VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
            + + +P         + + GRLD+D+ GL+++T++  L  +LT P     K+Y V V+ 
Sbjct: 94  -IYDLLPERWEFRNPKIVSVGRLDKDTSGLILVTDDTKLVHQLTSPKHHVDKVYQVSVDC 152

Query: 116 IPTQDALEALRNGVTLNDG--PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLY 173
               D +++   GV L +G    LPA  E+V E                       +TL 
Sbjct: 153 PLQSDIIDSFAKGVVLGEGAEQCLPAKIEIVSENVAN-------------------VTLN 193

Query: 174 EGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEW 212
           EG+  QVRRM A  G+    L R   G Y L +LA GEW
Sbjct: 194 EGKYHQVRRMFAACGYHVEALHRSQFGQYRLQDLAQGEW 232


>UniRef50_C7NDY8 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NDY8_LEPBD
          Length = 228

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 57/217 (26%), Positives = 102/217 (47%), Gaps = 25/217 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE-NQPTRVILFNKPYDVLPQFTDEAGRK 61
           +  ++    +  +     VK     R    + + N      + NKP  VL    D+ GR+
Sbjct: 26  RVTVN----KHEAIIGMDVKPEDVVRIDGERVKLNTRYEYYILNKPKRVLCSNEDKFGRR 81

Query: 62  TLKEFIPVQ-GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
              +FI  +  ++  GRLD  +EGL++++N+G +   +  P K+  K Y  +V       
Sbjct: 82  LAVDFIKSRARLFTYGRLDFMTEGLIIISNDGEVYNHVMHPRKKLYKSYIAKVSREIEDK 141

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            +EAL++GV ++   T PA  + +D+                     L+I ++EGRNRQ+
Sbjct: 142 DIEALQHGVVIDGKRTAPAKVKKIDKKE-------------------LRIAIFEGRNRQI 182

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVTD 217
           R+M   +G+    L R  +G+ +L NL  GE+R + +
Sbjct: 183 RKMLETLGYNVNSLKRIKVGELTLGNLQVGEYRALNE 219


>UniRef50_A6DMJ6 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DMJ6_9BACT
          Length = 239

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 57/220 (25%), Positives = 91/220 (41%), Gaps = 29/220 (13%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTL 63
             +++   QK       +             E + T   + NKP   +    DE   KT+
Sbjct: 34  VKVND-IPQKVGKSTIDL-ANDVVTFDGEVLEYRETIYFMLNKPKGYVCAAKDER-LKTV 90

Query: 64  KEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQ 119
            + +P     +  ++ GRLD D+ GL++LT++G     +T P ++  K Y V      + 
Sbjct: 91  LDLLPPALASREPFSCGRLDIDTTGLVILTDDGTWAHGITSPKRKCEKSYLVGSVSELSD 150

Query: 120 DALEALRNGVTL--NDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           + +  L  GV L  +D  T PA  E +DE                      ++ + EGR 
Sbjct: 151 EDMRNLEQGVYLDGDDKITAPAKIEKIDEK-------------------TYRLKITEGRY 191

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSL-DNLANGEWREVT 216
            QV+RM   V      L R  +G  SL D+L  G WR++T
Sbjct: 192 HQVKRMFEAVDNMVKSLHREQIGGLSLDDDLDEGNWRDLT 231


>UniRef50_C7H4Z6 Pseudouridine synthase n=1 Tax=Faecalibacterium prausnitzii A2-165
           RepID=C7H4Z6_9FIRM
          Length = 235

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 55/220 (25%), Positives = 93/220 (42%), Gaps = 27/220 (12%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKT 62
           +  ++    +K      Q++   S          +    ++ NKP  V+   TD+    T
Sbjct: 26  RVTVNGAVCKKGDT---QLREGDSVAVDGAPLAYRQFVYLMLNKPEGVVSASTDKRD-TT 81

Query: 63  LKEFI----PVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPT 118
           + + I    P + ++  GRLD+ S G ++LT++G     +  P +   K Y V ++   T
Sbjct: 82  VVDLIGDAYPRRELFPVGRLDKTSTGFVLLTDDGGFAHEILAPKRHVSKTYTVVIDTPLT 141

Query: 119 QDALEALRNGVTLNDGPTL-PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
           ++       GVTL DG  L PA  E +                       +K+ L +G  
Sbjct: 142 EEMRRGFAEGVTLADGTALSPAEVEALTPDGL-----------------TVKVRLRQGVY 184

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
            Q++RM    G     L R A+G  +LD  LA G+WRE++
Sbjct: 185 HQIKRMFGVYGAGVNALHRDAIGGLALDPALAPGQWRELS 224


>UniRef50_A8U4V7 Pseudouridine synthase n=10 Tax=Lactobacillales RepID=A8U4V7_9LACT
          Length = 239

 Score =  194 bits (493), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 59/220 (26%), Positives = 94/220 (42%), Gaps = 24/220 (10%)

Query: 2   RQFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRK 61
           +Q  ++  T+   S       +           + QP    + +KP  V+   +D    +
Sbjct: 25  KQVQVNGQTIMVDSLNV--DPQLQEVTVAGVPIDYQPHVYYMLHKPAGVVSAVSDAVN-Q 81

Query: 62  TLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           T+ + I       G++  GRLD+D+EGLL+LTNNG L  +L  P K   K Y V V    
Sbjct: 82  TVIDLIEPSQRVPGLFPVGRLDKDTEGLLLLTNNGQLGYQLLIPKKEVTKCYEVVVNERV 141

Query: 118 TQDALEALRNGVTLNDG-PTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGR 176
           T D   A   G+  + G    PA   ++                +S   S + + + EG+
Sbjct: 142 TDDDQLAFTAGIVFDGGVICKPAQLTILS---------------QSDTESRVLLEISEGK 186

Query: 177 NRQVRRMTAHVGFPTLRLIRYAMGDYSLDN-LANGEWREV 215
             QV++M   VG   + L R +MG   LD  L+ G +R +
Sbjct: 187 FHQVKKMFLSVGKKVIYLKRLSMGPLQLDKTLSLGSYRPL 226


>UniRef50_C6BUF1 RNA-binding S4 domain protein n=1 Tax=Desulfovibrio salexigens DSM
           2638 RepID=C6BUF1_DESAD
          Length = 251

 Score =  193 bits (491), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 57/221 (25%), Positives = 94/221 (42%), Gaps = 22/221 (9%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR---VILFNKPYDVLPQFTDEAG 59
           +  ++         +              +  ++        IL +K  + +    D  G
Sbjct: 32  KVKVNGELADSPGIQV--DPDNDRVEVNGKLVQHDEKSKDLYILLHKTIETVTTAKDPQG 89

Query: 60  RKTLKEFIPV----QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEG 115
           RKT+ + +P     + V+  GRLD  SEG+L+LT +G L  R+T P     KIY+V + G
Sbjct: 90  RKTVLDLLPPDVINRRVFPVGRLDFYSEGMLLLTTDGELCNRMTHPKWHLPKIYHVTIRG 149

Query: 116 IPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
             ++  L  ++NG+ L D   L A  ++                 +   T+  ++ L +G
Sbjct: 150 KLSEKELSVMQNGMYLEDKGELLAPVKI-------------KAISEVGETTKYEMELRQG 196

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
            NRQ+RRM        LRL R   G   L  L  G+WRE++
Sbjct: 197 INRQIRRMFGEFDKTILRLKRVRQGRIELGALKPGKWRELS 237


>UniRef50_B7A9J5 Pseudouridine synthase n=1 Tax=Thermus aquaticus Y51MC23
           RepID=B7A9J5_THEAQ
          Length = 245

 Score =  193 bits (491), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 58/199 (29%), Positives = 89/199 (44%), Gaps = 18/199 (9%)

Query: 18  NHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGR 77
              V   ++     R    +    +L +KP   +    +      L E  P + +   GR
Sbjct: 50  GFHVPEGAALEVEGRPLAVRRHLHLLLHKPAGYVTSRKEGPSVYALLEGFPTRDLSPVGR 109

Query: 78  LDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTL 137
           LD+D+EGLL+ T +G L  RLT P  +  K Y V +    T   + A + G+ L+   TL
Sbjct: 110 LDKDTEGLLLFTTDGELLHRLTHPRHKVEKRYLVHLLHPATAADVRAFQEGILLSGEKTL 169

Query: 138 PAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRY 197
           PA   L ++P                  +W+++TL EGR  QV+RM    G   L L R 
Sbjct: 170 PARLHLGEDP------------------TWVELTLLEGRFHQVKRMFQARGNQVLYLKRL 211

Query: 198 AMGDYSLDNLANGEWREVT 216
           A+G  +L++L  G  R +T
Sbjct: 212 ALGPLTLEDLPLGAARPLT 230


>UniRef50_D1PIW4 Pseudouridine synthase n=1 Tax=Subdoligranulum variabile DSM 15176
           RepID=D1PIW4_9FIRM
          Length = 237

 Score =  193 bits (491), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 64/222 (28%), Positives = 95/222 (42%), Gaps = 29/222 (13%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPE--NQPTRVILFNKPYDVLPQFTDEAGR 60
           +  ++    +K      QV   ++            Q    I+ NKP  V+    D+   
Sbjct: 27  RVAVNGMVCRKADT---QVAEDAAIAVDGTPLAGSYQKYVYIMLNKPEGVVSASRDKRD- 82

Query: 61  KTLKEF----IPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGI 116
            T+ +      P + ++ AGRLD+ S G ++LT++GAL   L  P     K Y V ++  
Sbjct: 83  TTVVDLVAADFPRRALFPAGRLDKTSTGFVLLTDDGALAHDLLSPAHHVDKQYLVTLDTP 142

Query: 117 PTQDALEALRNGVTLNDGPT-LPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEG 175
            T         GVTL DG T  PA AE   E                     +K+TL++G
Sbjct: 143 LTDAMRAGFAAGVTLADGETMAPAEAEPAGEDP-----------------CVVKVTLHQG 185

Query: 176 RNRQVRRMTAHVGFPTLRLIRYAMGDYSLD-NLANGEWREVT 216
              Q++RM    G     L RYA+G  +LD  LA G+WRE+T
Sbjct: 186 VYHQIKRMFGVYGAGVNALHRYAIGGVALDAALAPGQWRELT 227


>UniRef50_C7LZX4 Pseudouridine synthase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZX4_ACIFD
          Length = 254

 Score =  192 bits (490), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 61/215 (28%), Positives = 85/215 (39%), Gaps = 24/215 (11%)

Query: 3   QFIISENTMQKTSFRNHQVKRFSSQRSTRRKPENQPTR-VILFNKPYDVLPQFTDEAGRK 61
           +  I+       +     V           +   +  R   L NKP  V+    D  GR 
Sbjct: 31  RVRINGEVATIGARVRPGV---DRVEFDGLEIATEEQREYWLLNKPRGVVSSVVDPEGRP 87

Query: 62  TLKEFIPV-QGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           T++  +     VY  GRLD DSEGLL+LTN+G L  +LT P     K Y V V+    + 
Sbjct: 88  TVRSLVATTSRVYPVGRLDVDSEGLLILTNDGPLTYQLTHPRFHVPKEYLVWVDRPVPRR 147

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
               LR GV ++      +    V                       ++I L EGRNRQ+
Sbjct: 148 LGRELREGVEVDGELLRASSVGTVGP-------------------RLVRIVLTEGRNRQI 188

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREV 215
           RRM   VG    RL+R  +G     +L  G  R +
Sbjct: 189 RRMVGAVGLSVERLVRVRIGPLVDPHLPPGVARRL 223


>UniRef50_D1R854 Pseudouridine synthase n=4 Tax=Chlamydiales RepID=D1R854_9CHLA
          Length = 261

 Score =  192 bits (490), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 48/216 (22%), Positives = 77/216 (35%), Gaps = 25/216 (11%)

Query: 4   FIISENTMQKTSFRNHQVKRFSSQRSTRRKP-ENQPTRVILFNKPYDVLPQFTDEAGRKT 62
             ++             V          +   + Q     + NKP   +         K 
Sbjct: 59  VTVNGEVTLVPQTL---VDENDVITCKGQSVGKKQNKVYYILNKPIGYICSNKRNKDSKI 115

Query: 63  LKEFIP--VQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQD 120
           + +      + ++  GRLD+D+ GL+++TN+G    R+  P     K Y V+       +
Sbjct: 116 VLDLFDTVEERLFTVGRLDKDTSGLIIVTNDGHFANRVIHPSANIHKEYLVKTNEEVEAE 175

Query: 121 ALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQV 180
            L AL +G  +      P     V                       LKIT+ EG+ R++
Sbjct: 176 HLSALSSGTLVEKTFVRPIRVSKVRRG-------------------TLKITIAEGKKREI 216

Query: 181 RRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           R +      P L L R  +G   L  L  GEWRE+T
Sbjct: 217 RLLMESAKLPVLELTRIRIGGLHLGPLQPGEWREMT 252


>UniRef50_C0QWY7 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QWY7_BRAHW
          Length = 229

 Score =  192 bits (490), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 54/219 (24%), Positives = 89/219 (40%), Gaps = 26/219 (11%)

Query: 3   QFIISENTMQKTSFRNH---QVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAG 59
           + I + N         +   QV        +  +   +    I  NKP   +       G
Sbjct: 20  RLIQNGNVKVNGIINTNPATQVDENDKIECS-IEQYKENKIYIKLNKPRGYVVSSNKNEG 78

Query: 60  RKTLKEFIPVQ--GVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIP 117
           +  +   I      +Y  GRLD+DS GL++ TN+G    ++        K YYV+V+   
Sbjct: 79  KP-IYNLIKKDFDNIYPVGRLDKDSSGLILFTNDGVFAKQIIGENTNCEKEYYVRVDDNI 137

Query: 118 TQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRN 177
              AL+ L  G++L+     PA  + V++ +                     I L EG+N
Sbjct: 138 PDGALQKLEYGISLDGQKLKPAKVKRVNKNS-------------------FHIILTEGKN 178

Query: 178 RQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWREVT 216
           RQ+RRM   VGF  + L R  +    L++L  G ++ +T
Sbjct: 179 RQIRRMCQKVGFEVIILKRLRISGILLEDLKEGTFKSLT 217


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.175    0.551 

Lambda     K      H
   0.267   0.0534    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,656,956,224
Number of Sequences: 3077464
Number of extensions: 90361148
Number of successful extensions: 185307
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 2334
Number of HSP's successfully gapped in prelim test: 1364
Number of HSP's that attempted gapping in prelim test: 175620
Number of HSP's gapped (non-prelim): 4010
length of query: 217
length of database: 1,040,396,356
effective HSP length: 124
effective length of query: 93
effective length of database: 658,790,820
effective search space: 61267546260
effective search space used: 61267546260
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.0 bits)
S2: 91 (39.3 bits)
