Phyre 2 Results for P25906

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Email | l.a.kelley@imperial.ac.uk
Description | P25906
Date | Thu Jan 5 11:42:45 GMT 2012
Unique Job ID | 1d5f071109a354c6

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template d1lqaa_
Top template information
Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
Confidence and coverage
Confidence: | 100.0% | Coverage: | 98%
279 residues ( 98% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | S | S | N | T | F | T | L | G | T | K | S | V | N | R | L | G | Y | G | A | M | Q | L | A | G | P | G | V | F | G | P | P | R | D | R | H | V | A | I | T | V | L | R | E | A | L | A | L | G | V | N | H | I | D | T | S | D | F | Y | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | P | H | V | T | N | Q | I | I | R | E | A | L | Y | P | Y | S | D | D | L | T | I | V | T | K | I | G | A | R | R | G | E | D | A | S | W | L | P | A | F | S | P | A | E | L | Q | K | A | V | H | D | N | L | R | N | L | G | L | D | V | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | D | V | V | N | L | R | V | M | M | G | D | G | H | G | P | A | E | G | S | I | E | A | S | L | T | V | L | A | E | M | Q | Q | Q | G | L | V | K | H | I | G | L | S | N | V | T | P | T | Q | V | A | E | A | R | K | I | A | E | I | V | C
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | V | Q | N | E | Y | N | I | A | H | R | A | D | D | A | M | I | D | A | L | A | H | D | G | I | A | Y | V | P | F | F | P | L | G | G | F | T | P | L | Q | S | S | T | L | S | D | V | A | A | S | L | G | A | T | P | M | Q | V | A | L | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | .
Sequence |  | W | L | L | Q | R | S | P | N | I | L | L | I | P | G | T | S | S | V | A | H | L | R | E | N | M | A | A | E | K | L | H | L | S | E | E | V | L | S | T | L | D | G | I | S | R | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| d1lqaa_ |

### PDB 1lqa chain A

Region: 1 - 285
Aligned: 279
Modelled: 285
Confidence: 100.0%
Identity: 26%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
2 |
| d1pyfa_ |

### PDB 1pyf chain A

Region: 2 - 285
Aligned: 276
Modelled: 278
Confidence: 100.0%
Identity: 26%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
3 |
| c3erpA_ |

### PDB 3erp chain A

Region: 1 - 286
Aligned: 274
Modelled: 286
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: structure of idp01002, a putative oxidoreductase from and essential2 gene of salmonella typhimurium

Phyre2
4 |
| d1pz1a_ |

### PDB 1pz1 chain A

Region: 1 - 286
Aligned: 277
Modelled: 285
Confidence: 100.0%
Identity: 20%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
5 |
| d1ur3m_ |

### PDB 1ur3 chain M

Region: 1 - 286
Aligned: 275
Modelled: 286
Confidence: 100.0%
Identity: 21%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
6 |
| c3n2tA_ |

### PDB 3n2t chain A

Region: 1 - 285
Aligned: 276
Modelled: 285
Confidence: 100.0%
Identity: 21%
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: structure of the glycerol dehydrogenase akr11b4 from gluconobacter2 oxydans

Phyre2
7 |
| c1ynpA_ |

### PDB 1ynp chain A

Region: 1 - 286
Aligned: 258
Modelled: 280
Confidence: 100.0%
Identity: 26%
PDB header:oxidoreductase
Chain: A: PDB Molecule:oxidoreductase;
PDBTitle: aldo-keto reductase akr11c1 from bacillus halodurans (apo form)

Phyre2
8 |
| c3n6qF_ |

### PDB 3n6q chain F

Region: 1 - 286
Aligned: 274
Modelled: 286
Confidence: 100.0%
Identity: 24%
PDB header:oxidoreductase
Chain: F: PDB Molecule:yghz aldo-keto reductase;
PDBTitle: crystal structure of yghz from e. coli

Phyre2
9 |
| d3eaua1 |

### PDB 3eau chain A domain 1

Region: 3 - 286
Aligned: 271
Modelled: 284
Confidence: 100.0%
Identity: 25%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
10 |
| c3lutA_ |

### PDB 3lut chain A

Region: 3 - 286
Aligned: 271
Modelled: 284
Confidence: 100.0%
Identity: 25%
PDB header:membrane protein
Chain: A: PDB Molecule:voltage-gated potassium channel subunit beta-2;
PDBTitle: a structural model for the full-length shaker potassium channel kv1.2

Phyre2
11 |
| d1j96a_ |

### PDB 1j96 chain A

Region: 1 - 286
Aligned: 264
Modelled: 277
Confidence: 100.0%
Identity: 22%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
12 |
| d1q5ma_ |

### PDB 1q5m chain A

Region: 1 - 286
Aligned: 263
Modelled: 283
Confidence: 100.0%
Identity: 23%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
13 |
| c3up8B_ |

### PDB 3up8 chain B

Region: 2 - 286
Aligned: 256
Modelled: 283
Confidence: 100.0%
Identity: 24%
PDB header:oxidoreductase
Chain: B: PDB Molecule:putative 2,5-diketo-d-gluconic acid reductase b;
PDBTitle: crystal structure of a putative 2,5-diketo-d-gluconic acid reductase b

Phyre2
14 |
| d1gvea_ |

### PDB 1gve chain A

Region: 14 - 285
Aligned: 254
Modelled: 272
Confidence: 100.0%
Identity: 25%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
15 |
| c3f7jB_ |

### PDB 3f7j chain B

Region: 2 - 286
Aligned: 254
Modelled: 285
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: B: PDB Molecule:yvgn protein;
PDBTitle: b.subtilis yvgn

Phyre2
16 |
| c3h7uA_ |

### PDB 3h7u chain A

Region: 1 - 285
Aligned: 260
Modelled: 276
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase;
PDBTitle: crystal structure of the plant stress-response enzyme akr4c9

Phyre2
17 |
| d1us0a_ |

### PDB 1us0 chain A

Region: 1 - 285
Aligned: 260
Modelled: 285
Confidence: 100.0%
Identity: 25%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
18 |
| d1afsa_ |

### PDB 1afs chain A

Region: 1 - 285
Aligned: 263
Modelled: 276
Confidence: 100.0%
Identity: 22%
Fold: TIM beta/alpha-barrel
Superfamily: NAD(P)-linked oxidoreductase
Family: Aldo-keto reductases (NADP)

Phyre2
19 |
| c2bp1C_ |

### PDB 2bp1 chain C

Region: 12 - 285
Aligned: 255
Modelled: 274
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: C: PDB Molecule:aflatoxin b1 aldehyde reductase member 2;
PDBTitle: structure of the aflatoxin aldehyde reductase in complex2 with nadph

Phyre2
20 |
| c1vbjB_ |

### PDB 1vbj chain B

Region: 1 - 285
Aligned: 258
Modelled: 276
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: B: PDB Molecule:prostaglandin f synthase;
PDBTitle: the crystal structure of prostaglandin f synthase from2 trypanosoma brucei

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | d1lqaa_ |
|  | 100.0 | 26 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
2 | d1pyfa_ |
|  | 100.0 | 26 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
3 | c3erpA_ |
|  | 100.0 | 22 | PDB header:oxidoreductase Chain: A: PDB Molecule:putative oxidoreductase; PDBTitle: structure of idp01002, a putative oxidoreductase from and essential2 gene of salmonella typhimurium
4 | d1pz1a_ |
|  | 100.0 | 20 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
5 | d1ur3m_ |
|  | 100.0 | 21 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
6 | c3n2tA_ |
|  | 100.0 | 21 | PDB header:oxidoreductase Chain: A: PDB Molecule:putative oxidoreductase; PDBTitle: structure of the glycerol dehydrogenase akr11b4 from gluconobacter2 oxydans
7 | c1ynpA_ |
|  | 100.0 | 26 | PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase; PDBTitle: aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
8 | c3n6qF_ |
|  | 100.0 | 24 | PDB header:oxidoreductase Chain: F: PDB Molecule:yghz aldo-keto reductase; PDBTitle: crystal structure of yghz from e. coli
9 | d3eaua1 |
|  | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
10 | c3lutA_ |
|  | 100.0 | 25 | PDB header:membrane protein Chain: A: PDB Molecule:voltage-gated potassium channel subunit beta-2; PDBTitle: a structural model for the full-length shaker potassium channel kv1.2
11 | d1j96a_ |
|  | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
12 | d1q5ma_ |
|  | 100.0 | 23 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
13 | c3up8B_ |
|  | 100.0 | 24 | PDB header:oxidoreductase Chain: B: PDB Molecule:putative 2,5-diketo-d-gluconic acid reductase b; PDBTitle: crystal structure of a putative 2,5-diketo-d-gluconic acid reductase b
14 | d1gvea_ |
|  | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
15 | c3f7jB_ |
|  | 100.0 | 22 | PDB header:oxidoreductase Chain: B: PDB Molecule:yvgn protein; PDBTitle: b.subtilis yvgn
16 | c3h7uA_ |
|  | 100.0 | 22 | PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase; PDBTitle: crystal structure of the plant stress-response enzyme akr4c9
17 | d1us0a_ |
|  | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
18 | d1afsa_ |
|  | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
19 | c2bp1C_ |
|  | 100.0 | 23 | PDB header:oxidoreductase Chain: C: PDB Molecule:aflatoxin b1 aldehyde reductase member 2; PDBTitle: structure of the aflatoxin aldehyde reductase in complex2 with nadph
20 | c1vbjB_ |
|  | 100.0 | 22 | PDB header:oxidoreductase Chain: B: PDB Molecule:prostaglandin f synthase; PDBTitle: the crystal structure of prostaglandin f synthase from2 trypanosoma brucei
21 | c2wztA_ |
| not modelled | 100.0 | 21 | PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase; PDBTitle: crystal structure of a mycobacterium aldo-keto reductase in2 its apo and liganded form
22 | c3o0kB_ |
| not modelled | 100.0 | 22 | PDB header:oxidoreductase Chain: B: PDB Molecule:aldo/keto reductase; PDBTitle: crystal structure of aldo/keto reductase from brucella melitensis
23 | d1qwka_ |
| not modelled | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
24 | d1hqta_ |
| not modelled | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
25 | d1mi3a_ |
| not modelled | 100.0 | 20 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
26 | c3h7rA_ |
| not modelled | 100.0 | 23 | PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase; PDBTitle: crystal structure of the plant stress-response enzyme akr4c8
27 | d1s1pa_ |
| not modelled | 100.0 | 23 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
28 | d1frba_ |
| not modelled | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
29 | c3b3dA_ |
| not modelled | 100.0 | 23 | PDB header:oxidoreductase Chain: A: PDB Molecule:putative morphine dehydrogenase; PDBTitle: b.subtilis ytbe
30 | d1hw6a_ |
| not modelled | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
31 | d2alra_ |
| not modelled | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
32 | c1zgdB_ |
| not modelled | 100.0 | 21 | PDB header:plant protein Chain: B: PDB Molecule:chalcone reductase; PDBTitle: chalcone reductase complexed with nadp+ at 1.7 angstrom2 resolution
33 | c3buvB_ |
| not modelled | 100.0 | 20 | PDB header:oxidoreductase Chain: B: PDB Molecule:3-oxo-5-beta-steroid 4-dehydrogenase; PDBTitle: crystal structure of human delta(4)-3-ketosteroid 5-beta-reductase in2 complex with nadp and hepes. resolution: 1.35 a.
34 | c2bgsA_ |
| not modelled | 100.0 | 26 | PDB header:oxidoreductase Chain: A: PDB Molecule:aldose reductase; PDBTitle: holo aldose reductase from barley
35 | d1c9wa_ |
| not modelled | 100.0 | 25 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
36 | d1vp5a_ |
| not modelled | 100.0 | 26 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
37 | d1ah4a_ |
| not modelled | 100.0 | 26 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
38 | d1mzra_ |
| not modelled | 100.0 | 22 | Fold:TIM beta/alpha-barrel Superfamily:NAD(P)-linked oxidoreductase Family:Aldo-keto reductases (NADP)
39 | c3krbB_ |
| not modelled | 100.0 | 25 | PDB header:oxidoreductase Chain: B: PDB Molecule:aldose reductase; PDBTitle: structure of aldose reductase from giardia lamblia at 1.75a resolution
40 | c3ln3A_ |
| not modelled | 100.0 | 21 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrodiol dehydrogenase; PDBTitle: crystal structure of putative reductase (np_038806.2) from2 mus musculus at 1.18 a resolution
41 | c3ktcB_ |
| not modelled | 88.5 | 14 | PDB header:isomerase Chain: B: PDB Molecule:xylose isomerase; PDBTitle: crystal structure of putative sugar isomerase (yp_050048.1) from2 erwinia carotovora atroseptica scri1043 at 1.54 a resolution
42 | d1jpma1 |
| not modelled | 73.4 | 11 | Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:D-glucarate dehydratase-like
43 | c3g8rA_ |
| not modelled | 56.9 | 20 | PDB header:biosynthetic protein Chain: A: PDB Molecule:probable spore coat polysaccharide biosynthesis protein e; PDBTitle: crystal structure of putative spore coat polysaccharide biosynthesis2 protein e from chromobacterium violaceum atcc 12472
44 | c2ph5A_ |
| not modelled | 55.3 | 17 | PDB header:transferase Chain: A: PDB Molecule:homospermidine synthase; PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54
45 | c2vc7A_ |
| not modelled | 38.2 | 11 | PDB header:hydrolase Chain: A: PDB Molecule:aryldialkylphosphatase; PDBTitle: structural basis for natural lactonase and promiscuous2 phosphotriesterase activities
46 | c3ik4A_ |
| not modelled | 37.5 | 10 | PDB header:isomerase Chain: A: PDB Molecule:mandelate racemase/muconate lactonizing protein; PDBTitle: crystal structure of mandelate racemase/muconate lactonizing protein2 from herpetosiphon aurantiacus
47 | c3oqbF_ |
| not modelled | 35.1 | 12 | PDB header:oxidoreductase Chain: F: PDB Molecule:oxidoreductase; PDBTitle: crystal structure of putative oxidoreductase from bradyrhizobium2 japonicum usda 110
48 | c6paxA_ |
| not modelled | 30.9 | 20 | PDB header:gene regulation/dna Chain: A: PDB Molecule:homeobox protein pax-6; PDBTitle: crystal structure of the human pax-6 paired domain-dna2 complex reveals a general model for pax protein-dna3 interactions
49 | d2gdqa1 |
| not modelled | 30.5 | 10 | Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:D-glucarate dehydratase-like
50 | d1yeya1 |
| not modelled | 30.2 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:D-glucarate dehydratase-like
51 | d1pdnc_ |
| not modelled | 27.3 | 18 | Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain
52 | c2k27A_ |
| not modelled | 24.9 | 20 | PDB header:transcription regulator Chain: A: PDB Molecule:paired box protein pax-8; PDBTitle: solution structure of human pax8 paired box domain
53 | d1vp8a_ |
| not modelled | 24.4 | 18 | Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like
54 | c3noeA_ |
| not modelled | 23.9 | 11 | PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa
55 | c2qdeA_ |
| not modelled | 23.8 | 9 | PDB header:lyase Chain: A: PDB Molecule:mandelate racemase/muconate lactonizing enzyme family PDBTitle: crystal structure of mandelate racemase/muconate lactonizing family2 protein from azoarcus sp. ebn1
56 | d1k78a1 |
| not modelled | 22.7 | 29 | Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain
57 | c3ng3A_ |
| not modelled | 22.2 | 21 | PDB header:lyase Chain: A: PDB Molecule:deoxyribose-phosphate aldolase; PDBTitle: crystal structure of deoxyribose phosphate aldolase from mycobacterium2 avium 104 in a schiff base with an unknown aldehyde
58 | c1xuzA_ |
| not modelled | 20.8 | 19 | PDB header:biosynthetic protein Chain: A: PDB Molecule:polysialic acid capsule biosynthesis protein siac; PDBTitle: crystal structure analysis of sialic acid synthase (neub)from2 neisseria meningitidis, bound to mn2+, phosphoenolpyruvate, and n-3 acetyl mannosaminitol
59 | d1vcva1 |
| not modelled | 20.7 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase
60 | d6paxa1 |
| not modelled | 20.7 | 27 | Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain
61 | c3oa3A_ |
| not modelled | 20.2 | 14 | PDB header:lyase Chain: A: PDB Molecule:aldolase; PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 coccidioides immitis
62 | c1vliA_ |
| not modelled | 19.9 | 15 | PDB header:biosynthetic protein Chain: A: PDB Molecule:spore coat polysaccharide biosynthesis protein spse; PDBTitle: crystal structure of spore coat polysaccharide biosynthesis protein2 spse (bsu37870) from bacillus subtilis at 2.38 a resolution
63 | d1o0ya_ |
| not modelled | 18.8 | 17 | Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase
64 | c1jpmB_ |
| not modelled | 18.4 | 11 | PDB header:isomerase Chain: B: PDB Molecule:l-ala-d/l-glu epimerase; PDBTitle: l-ala-d/l-glu epimerase
65 | c2yciX_ |
| not modelled | 17.6 | 14 | PDB header:transferase Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein PDBTitle: methyltransferase native
66 | c3ddmD_ |
| not modelled | 17.0 | 12 | PDB header:lyase Chain: D: PDB Molecule:putative mandelate racemase/muconate lactonizing PDBTitle: crystal structure of mandelate racemase/muconate2 lactonizing enzyme from bordetella bronchiseptica rb50
67 | c3l8mA_ |
| not modelled | 16.9 | 10 | PDB header:transferase Chain: A: PDB Molecule:probable thiamine pyrophosphokinase; PDBTitle: crystal structure of a probable thiamine pyrophosphokinase2 from staphylococcus saprophyticus subsp. saprophyticus.3 northeast structural genomics consortium target id syr86
68 | c2oz8B_ |
| not modelled | 15.6 | 10 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:mll7089 protein; PDBTitle: crystal structure of putative mandelate racemase from mesorhizobium2 loti
69 | d1f6ya_ |
| not modelled | 15.4 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Methyltetrahydrofolate-utiluzing methyltransferases
70 | c3ngjC_ |
| not modelled | 14.2 | 17 | PDB header:lyase Chain: C: PDB Molecule:deoxyribose-phosphate aldolase; PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 entamoeba histolytica
71 | c3smaD_ |
| not modelled | 14.2 | 18 | PDB header:transferase Chain: D: PDB Molecule:frbf; PDBTitle: a new n-acetyltransferase fold in the structure and mechanism of the2 phosphonate biosynthetic enzyme frbf
72 | d1t57a_ |
| not modelled | 13.9 | 21 | Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like
73 | d1zata2 |
| not modelled | 13.0 | 13 | Fold:L,D-transpeptidase pre-catalytic domain-like Superfamily:L,D-transpeptidase pre-catalytic domain-like Family:L,D-transpeptidase pre-catalytic domain-like
74 | c3ic5A_ |
| not modelled | 12.5 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative saccharopine dehydrogenase; PDBTitle: n-terminal domain of putative saccharopine dehydrogenase from ruegeria2 pomeroyi.
75 | d1ydwa1 |
| not modelled | 12.1 | 18 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
76 | c3ihkC_ |
| not modelled | 11.7 | 15 | PDB header:transferase Chain: C: PDB Molecule:thiamin pyrophosphokinase; PDBTitle: crystal structure of thiamin pyrophosphokinase from2 s.mutans, northeast structural genomics consortium target3 smr83
77 | c3e4fB_ |
| not modelled | 11.6 | 25 | PDB header:transferase Chain: B: PDB Molecule:aminoglycoside n3-acetyltransferase; PDBTitle: crystal structure of ba2930- a putative aminoglycoside n3-2 acetyltransferase from bacillus anthracis
78 | d1wlza1 |
| not modelled | 11.4 | 22 | Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins
79 | c1wlzD_ |
| not modelled | 11.4 | 22 | PDB header:unknown function Chain: D: PDB Molecule:cap-binding protein complex interacting protein PDBTitle: crystal structure of djbp fragment which was obtained by2 limited proteolysis
80 | c2p0oA_ |
| not modelled | 9.6 | 17 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein duf871; PDBTitle: crystal structure of a conserved protein from locus ef_2437 in2 enterococcus faecalis with an unknown function
81 | d1sjda1 |
| not modelled | 9.4 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:D-glucarate dehydratase-like
82 | d2nu7a1 |
| not modelled | 8.6 | 8 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:CoA-binding domain
83 | c3ju2A_ |
| not modelled | 8.6 | 13 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein smc04130; PDBTitle: crystal structure of protein smc04130 from sinorhizobium meliloti 1021
84 | c2ixaA_ |
| not modelled | 8.3 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:alpha-n-acetylgalactosaminidase; PDBTitle: a-zyme, n-acetylgalactosaminidase
85 | c3dtyA_ |
| not modelled | 8.2 | 19 | PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase, gfo/idh/moca family; PDBTitle: crystal structure of an oxidoreductase from pseudomonas2 syringae
86 | c3bjsB_ |
| not modelled | 8.2 | 12 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:mandelate racemase/muconate lactonizing enzyme; PDBTitle: crystal structure of a member of enolase superfamily from polaromonas2 sp. js666
87 | d1gr0a1 |
| not modelled | 8.2 | 15 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
88 | d2ou3a1 |
| not modelled | 8.2 | 13 | Fold:TerB-like Superfamily:TerB-like Family:COG3793-like
89 | c1lc3A_ |
| not modelled | 7.6 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:biliverdin reductase a; PDBTitle: crystal structure of a biliverdin reductase enzyme-cofactor2 complex
90 | d1nu5a1 |
| not modelled | 7.4 | 8 | Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:D-glucarate dehydratase-like
91 | d2ijqa1 |
| not modelled | 7.3 | 30 | Fold:Hyaluronidase domain-like Superfamily:TTHA0068-like Family:TTHA0068-like
92 | c3melC_ |
| not modelled | 7.2 | 30 | PDB header:structural genomics, unknown function Chain: C: PDB Molecule:thiamin pyrophosphokinase family protein; PDBTitle: crystal structure of thiamin pyrophosphokinase family protein from2 enterococcus faecalis, northeast structural genomics consortium3 target efr150
93 | d2plca_ |
| not modelled | 7.2 | 38 | Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Bacterial PLC
94 | c3es8D_ |
| not modelled | 6.9 | 11 | PDB header:isomerase, lyase Chain: D: PDB Molecule:muconate cycloisomerase; PDBTitle: crystal structure of divergent enolase from oceanobacillus2 iheyensis complexed with mg and l-malate.
95 | d1x87a_ |
| not modelled | 6.9 | 13 | Fold:Urocanase Superfamily:Urocanase Family:Urocanase
96 | d1bxba_ |
| not modelled | 6.8 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase
97 | c2wjeA_ |
| not modelled | 6.7 | 30 | PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase cpsb; PDBTitle: crystal structure of the tyrosine phosphatase cps4b from2 steptococcus pneumoniae tigr4.
98 | d2nyga1 |
| not modelled | 6.5 | 18 | Fold:TTHA0583/YokD-like Superfamily:TTHA0583/YokD-like Family:Aminoglycoside 3-N-acetyltransferase-like
99 | d1mzha_ |
| not modelled | 6.5 | 17 | Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0