BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (266 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia ...   307   3e-82
UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphometh...   267   3e-70
UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular ...   254   3e-66
UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteoba...   249   8e-65
UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   247   3e-64
UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   238   2e-61
UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria...   236   8e-61
UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionell...   233   4e-60
UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspi...   233   5e-60
UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamin...   228   1e-58
UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyr...   222   1e-56
UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroid...   221   2e-56
UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria...   221   2e-56
UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsi...   216   5e-55
UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Br...   214   2e-54
UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   214   2e-54
UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH     211   2e-53
UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicro...   210   3e-53
UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   210   4e-53
UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovu...   210   5e-53
UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   208   1e-52
UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria...   205   1e-51
UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Fl...   205   1e-51
UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Cor...   204   2e-51
UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenho...   202   1e-50
UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokel...   201   2e-50
UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinib...   201   2e-50
UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroi...   201   3e-50
UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingoba...   201   3e-50
UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebact...   200   3e-50
UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli ...   200   4e-50
UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular ...   200   5e-50
UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntropho...   199   7e-50
UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantell...   197   2e-49
UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM      197   4e-49
UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   196   8e-49
UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 clu...   195   2e-48
UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   194   3e-48
UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomon...   194   3e-48
UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria...   193   4e-48
UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria...   193   5e-48
UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria ...   192   1e-47
UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   191   3e-47
UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria...   189   8e-47
UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillal...   189   1e-46
UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   188   1e-46
UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptoco...   188   2e-46
UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquifical...   188   2e-46
UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   188   2e-46
UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   188   2e-46
UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobiu...   187   2e-46
UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharop...   187   4e-46
UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacte...   185   1e-45
UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   184   2e-45
UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S...   184   3e-45
UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   184   4e-45
UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobac...   183   4e-45
UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobac...   183   7e-45
UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   182   8e-45
UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionib...   182   1e-44
UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   181   2e-44
UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   181   2e-44
UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicute...   180   4e-44
UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria ...   180   4e-44
UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agarica...   180   4e-44
UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   180   5e-44
UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia d...   179   9e-44
UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rh...   179   1e-43
UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   178   1e-43
UniRef50_C2CTG3 Multifunctional thiamine-phosphate pyrophosphory...   177   3e-43
UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria ...   177   4e-43
UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=unculture...   177   5e-43
UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   176   6e-43
UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Ru...   176   9e-43
UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobia...   174   3e-42
UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   172   1e-41
UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   172   1e-41
UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   171   2e-41
UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniob...   171   2e-41
UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholde...   171   2e-41
UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   171   3e-41
UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpy...   170   5e-41
UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpy...   170   5e-41
UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   169   8e-41
UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kina...   168   1e-40
UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetoco...   167   3e-40
UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprother...   167   3e-40
UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   167   3e-40
UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S...   166   5e-40
UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasma...   166   8e-40
UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria ...   166   9e-40
UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovi...   165   1e-39
UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanae...   165   1e-39
UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobaci...   165   1e-39
UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_...   165   1e-39
UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochloro...   165   1e-39
UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepI...   164   2e-39
UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q...   164   3e-39
UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfati...   164   4e-39
UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridi...   162   1e-38
UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leo...   160   3e-38
UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobact...   160   3e-38
UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   160   4e-38
UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Ve...   160   5e-38
UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermob...   160   5e-38
UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   159   9e-38
UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular...   158   1e-37
UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobacul...   158   2e-37
UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS2...   157   3e-37
UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobac...   157   4e-37
UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   156   8e-37
UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   155   2e-36
UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofu...   154   3e-36
UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaer...   154   3e-36
UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomo...   154   4e-36
UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (H...   153   5e-36
UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   153   6e-36
UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   153   7e-36
UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermopla...   152   9e-36
UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadr...   152   9e-36
UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosa...   152   1e-35
UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes...   152   2e-35
UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobac...   152   2e-35
UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyri...   151   2e-35
UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodes...   150   3e-35
UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   150   3e-35
UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   149   8e-35
UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynt...   149   8e-35
UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella...   149   1e-34
UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioi...   148   1e-34
UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphil...   148   2e-34
UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=...   148   2e-34
UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolob...   147   3e-34
UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 ...   147   4e-34
UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   147   4e-34
UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   147   5e-34
UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta pro...   145   2e-33
UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   144   2e-33
UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold...   144   2e-33
UniRef50_A1ESK8 Phosphomethylpyrimidine kinase (Fragment) n=1 Ta...   144   3e-33
UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax...   143   5e-33
UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), Th...   143   5e-33
UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium...   143   6e-33
UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanoca...   143   6e-33
UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomy...   143   7e-33
UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobact...   142   1e-32
UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 ...   141   2e-32
UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospir...   141   3e-32
UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospir...   141   3e-32
UniRef50_D0LJB6 Phosphomethylpyrimidine kinase n=1 Tax=Haliangiu...   140   3e-32
UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas...   140   5e-32
UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkal...   140   6e-32
UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Co...   140   6e-32
UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatu...   139   8e-32
UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phos...   139   1e-31
UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   138   1e-31
UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   138   2e-31
UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   138   2e-31
UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidi...   137   3e-31
UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-...   137   3e-31
UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma...   137   5e-31
UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   136   6e-31
UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivall...   136   6e-31
UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=...   135   1e-30
UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Loddero...   135   2e-30
UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular...   135   2e-30
UniRef50_Q4P8E5 Putative uncharacterized protein n=1 Tax=Ustilag...   134   4e-30
UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus ...   134   5e-30
UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   133   6e-30
UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomyc...   133   7e-30
UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolob...   133   7e-30
UniRef50_Q0FHB8 Phosphomethylpyrimidine kinase ThiD n=2 Tax=Rhod...   132   8e-30
UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcani...   132   8e-30
UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosph...   132   1e-29
UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpy...   132   1e-29
UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax...   132   1e-29
UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular...   132   2e-29
UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogeno...   132   2e-29
UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Ge...   132   2e-29
UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosac...   131   2e-29
UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bactero...   131   2e-29
UniRef50_C8PKC3 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   131   2e-29
UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerot...   131   3e-29
UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine ar...   131   3e-29
UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   130   4e-29
UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   129   1e-28
UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Man...   128   2e-28
UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanoco...   128   2e-28
UniRef50_A0Y7H0 Phosphomethylpyrimidine kinase ThiD/thiamin-phos...   127   3e-28
UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=...   127   5e-28
UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax...   126   6e-28
UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular ...   126   6e-28
UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiob...   125   1e-27
UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteob...   125   1e-27
UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonell...   125   1e-27
UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermans...   125   2e-27
UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpy...   125   2e-27
UniRef50_Q9XDA0 Phosphomethylpyrimidine kinase (Fragment) n=3 Ta...   125   2e-27
UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacte...   124   4e-27
UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Mar...   123   6e-27
UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   123   6e-27
UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglo...   122   9e-27
UniRef50_A3EQ29 Phosphomethylpyrimidine kinase n=2 Tax=Leptospir...   121   2e-26
UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q75...   121   2e-26
UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia ...   121   3e-26
UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavisp...   120   4e-26
UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   120   4e-26
UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisp...   120   5e-26
UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria Re...   120   5e-26
UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) ...   120   5e-26
UniRef50_C9MT59 Thiamine-phosphate pyrophosphorylase/phosphometh...   120   7e-26
UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobact...   119   8e-26
UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales Re...   119   1e-25
UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax...   118   2e-25
UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobu...   118   3e-25
UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax...   117   3e-25
UniRef50_C4LKS0 Phosphomethylpyrimidine kinase n=1 Tax=Corynebac...   117   3e-25
UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepI...   117   4e-25
UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CB...   117   4e-25
UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella ...   117   6e-25
UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=...   116   6e-25
UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   116   7e-25
UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Ta...   116   9e-25
UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) ...   116   9e-25
UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Sac...   115   1e-24
UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 T...   115   1e-24
UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobact...   115   1e-24
UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosph...   115   1e-24
UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   115   2e-24
UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   114   3e-24
UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptoco...   114   4e-24
UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochrom...   113   6e-24
UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kan...   113   6e-24
UniRef50_B8CNV7 Phosphomethylpyrimidine kinase/thiamin-phosphate...   113   6e-24
UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   113   6e-24
UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobact...   113   7e-24
UniRef50_C9RIY8 Phosphomethylpyrimidine kinase n=1 Tax=Fibrobact...   113   7e-24
UniRef50_A4NVQ6 Phosphomethylpyrimidine kinase n=2 Tax=Haemophil...   113   7e-24
UniRef50_Q11YI3 Phosphomethylpyrimidine kinase n=1 Tax=Cytophaga...   112   9e-24
UniRef50_D1PXN3 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   112   1e-23
UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepI...   112   2e-23
UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobac...   112   2e-23
UniRef50_A1ZKW7 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   111   3e-23
UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 ope...   111   3e-23
UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neoricket...   110   3e-23
UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Pro...   110   7e-23
UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa...   108   2e-22
UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithio...   107   4e-22
UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosph...   107   4e-22
UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Br...   107   4e-22

>UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2N6_WIGBR
          Length = 272

 Score =  307 bits (786), Expect = 3e-82,   Method: Compositional matrix adjust.
 Identities = 132/268 (49%), Positives = 200/268 (74%), Gaps = 2/268 (0%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK+I   L+IAGTDP+ GAGIQ DLKTFSALGAYG +VIT+LV+QNT+GVQS+Y++  + 
Sbjct: 1   MKKIYKILSIAGTDPTCGAGIQCDLKTFSALGAYGLTVITSLVSQNTKGVQSIYKLPINV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           + +Q++SVFSDV+ID+ KIGML ++ I+E + + +++Y I  ++LD VM +K G  LL  
Sbjct: 61  IKSQINSVFSDVKIDSIKIGMLYDSAIIETIYKEIKKYYIPWIILDPVMSSKDGSCLLKK 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            ++  ++  L P  S++TPNL E++ +L+   A+ E ++ EQG+++L  GC  VLMKGGH
Sbjct: 121 RSINKIKKLLFPISSIVTPNLKESSLILNCSIAKNESQLKEQGKAILEYGCNMVLMKGGH 180

Query: 180 L-DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L ++++S DWL ++  E +F   RI TKNTHGTGC+LS+A+AAL P+  NW +T++++KS
Sbjct: 181 LKNNKESSDWLISKNKEIKFKGVRINTKNTHGTGCSLSSAIAALMPKFCNWEETIKKSKS 240

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAWW 266
           WL  ++ +++ L +G GIGP+HHF+  W
Sbjct: 241 WLEMSIYKSNKLNIGKGIGPIHHFYNLW 268


>UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphomethylpyrimidine kinase
           n=15 Tax=Bacteria RepID=C1AE24_GEMAT
          Length = 493

 Score =  267 bits (682), Expect = 3e-70,   Method: Compositional matrix adjust.
 Identities = 147/262 (56%), Positives = 177/262 (67%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           NALTIAG+DPSGGAGIQADLKTF+A   YG + +TAL AQNTRGV  V+ + P FV  QL
Sbjct: 230 NALTIAGSDPSGGAGIQADLKTFAAQRVYGMAALTALTAQNTRGVAGVHVVPPVFVLQQL 289

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +S+F D+RID  KIGM+A  DI   VA+ L+      VVLD VM+AK G  LL P AV  
Sbjct: 290 ESLFDDIRIDAVKIGMIATADIATTVADVLEERMRGPVVLDPVMIAKGGAELLRPDAVDA 349

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R+RLLP  ++ITPNL EAA LL+ P A T  EM  Q   L A+G  AVL+KGGHL +E+
Sbjct: 350 VRTRLLPLATVITPNLAEAAHLLNMPMASTRAEMETQATLLRALGPQAVLLKGGHLTEER 409

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           SPD L T +G   F  PR+ T NTHGTGCTLSAA+AA      N    V+ AK +++ A+
Sbjct: 410 SPDCLVTSDGVHWFDGPRVATANTHGTGCTLSAAIAAGLAGGGNLLTVVRTAKQYVTDAI 469

Query: 245 AQADTLEVGHGIGPVHHFHAWW 266
           A A  L VGHG GP HHFH  W
Sbjct: 470 ASAHRLTVGHGHGPTHHFHNLW 491


>UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular organisms
           RepID=A1K3Q3_AZOSB
          Length = 284

 Score =  254 bits (648), Expect = 3e-66,   Method: Compositional matrix adjust.
 Identities = 139/270 (51%), Positives = 176/270 (65%), Gaps = 8/270 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L+IAG DPSGGAGI AD+KTFSALGAYGC VI AL AQNT+ V  V+    DF+  QL
Sbjct: 13  NVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQL 72

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D++F+DV +  TKIGML   ++   VA+RL  +Q  NVVLD VM+AKSGD LL+ +A+A 
Sbjct: 73  DTLFADVAVHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIAM 132

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEML---EQGRSLLAMGCGA-VLMKGGHL 180
           +R  L PQ  +ITPNLPEA  LL+     + +EM    E+ R LL +     V++KGGHL
Sbjct: 133 MREALFPQSFMITPNLPEAGVLLEQRAPESVKEMYRAAERLRELLPLSSERWVMLKGGHL 192

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR----HTNWADTVQEA 236
              +  D LF  +      APRI T+NTHGTGCTLS+A+AAL P+           V++A
Sbjct: 193 PGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAGGFRGVEAAVRQA 252

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           + WL  A+A +  L VG G GPVHHFHA W
Sbjct: 253 RQWLLGAIAHSGDLGVGSGHGPVHHFHALW 282


>UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteobacteria
           RepID=A3P597_BURP0
          Length = 336

 Score =  249 bits (635), Expect = 8e-65,   Method: Compositional matrix adjust.
 Identities = 149/263 (56%), Positives = 179/263 (68%), Gaps = 2/263 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAGTDP+GGAGIQADLK FSA+ AYG + ITA+VAQNT GV+S   ++P FVA Q+
Sbjct: 74  NVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQI 133

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+VF DV +   KIGM+A   I EAVA  L R++   VVLD VM+AKSGD LL P AV  
Sbjct: 134 DAVFDDVAVHAVKIGMIATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDA 193

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R +L+P  +LITPNLPEA  LL     RT  EM      L A+G   VL+KGGHL  E+
Sbjct: 194 IRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWVLLKGGHLAGER 253

Query: 185 SPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           S D L          +APR+ T N HGTGCTLSAA+AAL P H+   D+V +AK++LS A
Sbjct: 254 SVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHS-VEDSVCQAKAYLSDA 312

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           LA +  LEVG G GPVHHFHA W
Sbjct: 313 LAASGELEVGRGHGPVHHFHALW 335


>UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=A5VNE7_BRUO2
          Length = 304

 Score =  247 bits (631), Expect = 3e-64,   Method: Compositional matrix adjust.
 Identities = 138/261 (52%), Positives = 181/261 (69%), Gaps = 2/261 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +TIAG+D SGGAGIQADLK FSALG YG SVI A+  QNTR V +V+ + P  VA Q+D+
Sbjct: 37  VTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQIDA 96

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VFSD+ +   KIGM++  + +EA+A  L  +    +VLD VM+AKSGD LLS +A+++LR
Sbjct: 97  VFSDLDVAAVKIGMVSVPETIEAIAHGLAHFS-GPIVLDPVMVAKSGDRLLSETAISSLR 155

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            +LLP  +L+TPN PEAA LLD   A ++ E  EQGR+LL +G  AVLMKGGH +     
Sbjct: 156 KKLLPLATLLTPNRPEAACLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGAICT 215

Query: 187 DWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L  R+    R  APRI+T NTHGTGCTLS+A+AA   R+ +    + +A ++L  A+ 
Sbjct: 216 DLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGLSRNLSLETALAQAHAYLQGAIR 275

Query: 246 QADTLEVGHGIGPVHHFHAWW 266
            AD+L+VG G GPVHHFHA W
Sbjct: 276 AADSLKVGQGHGPVHHFHALW 296


>UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=348
           Tax=Bacteria RepID=THID_RHIME
          Length = 266

 Score =  238 bits (606), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 132/261 (50%), Positives = 175/261 (67%), Gaps = 1/261 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG+D  GGAGIQADLKTFSALG YG SVITA+ AQNTRGV +V  +  + V+AQ+D
Sbjct: 5   ALSIAGSDSGGGAGIQADLKTFSALGVYGASVITAITAQNTRGVTAVEDVSAEIVSAQMD 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +VFSD+ +   KIGM++  + + A+A+ L+R+  +  V+D VM+A SGD LL P AVA L
Sbjct: 65  AVFSDLDVKAVKIGMVSRRETIAAIADGLRRFG-KRAVVDPVMVATSGDALLRPDAVAAL 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
              LLP   ++TPNL EAA +     A  E EM  Q  +++  G  AVL+KGGHL  +++
Sbjct: 124 IEELLPLALVVTPNLAEAALMTGRAIAGDEAEMARQAEAIMRTGAHAVLVKGGHLKGQEA 183

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D  F  +   R  A RI T+N HGTGCTLSAA+AA   +     + V  AK++L +A++
Sbjct: 184 TDLFFDGDTLVRLPAGRIETRNDHGTGCTLSAAIAAGLAKGVPLIEAVSAAKAYLHAAIS 243

Query: 246 QADTLEVGHGIGPVHHFHAWW 266
            AD LE+G G GPVHHFH WW
Sbjct: 244 AADRLEIGQGRGPVHHFHRWW 264


>UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria RepID=B7VS71_VIBSL
          Length = 302

 Score =  236 bits (601), Expect = 8e-61,   Method: Compositional matrix adjust.
 Identities = 129/259 (49%), Positives = 178/259 (68%), Gaps = 1/259 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQAD+K  SA G++ CSVITA+ +QNT+GV +++ I  D VA+QLD+
Sbjct: 38  LTIAGSDSGGGAGIQADIKAMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVASQLDA 97

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF+D+ I   K+GMLA++ I++ VA+++++Y+ +++V+D VM+A SGD LL  SA+ TL+
Sbjct: 98  VFTDLNIVAVKVGMLADSQIIKVVADKIKQYRPKHLVIDPVMVATSGDLLLENSAITTLK 157

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-DEQS 185
             L+P   +ITPNLPE AAL   P   +E EM      L A+G  AVL+KGGHL+ DE S
Sbjct: 158 QELIPLADIITPNLPEGAALTGKPVPESEAEMQGMIEDLRALGAKAVLLKGGHLEKDENS 217

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L         +A R  TKNTHGTGCTLS+A+A+   +    A+ V   K ++S A+A
Sbjct: 218 NDLLILPTTSALISAKRFPTKNTHGTGCTLSSAIASFLAQGNTLAEAVDLGKQYISRAIA 277

Query: 246 QADTLEVGHGIGPVHHFHA 264
            AD L+VG G GPV+HF A
Sbjct: 278 HADELQVGQGHGPVNHFFA 296


>UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionella
           RepID=C6MZJ4_9GAMM
          Length = 273

 Score =  233 bits (594), Expect = 4e-60,   Method: Compositional matrix adjust.
 Identities = 129/262 (49%), Positives = 169/262 (64%), Gaps = 3/262 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG D SGGAGIQADLKTFSA G YG +V+TAL  QNT GV++ Y I    +  QL +
Sbjct: 6   LSIAGFDGSGGAGIQADLKTFSAFGCYGMTVLTALPVQNTCGVRNCYDIPLQAIDDQLHA 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATL 125
           +F D+R D  KIGML  ++I+E VA  L+++     ++LD V +AKSGDPLL P AV TL
Sbjct: 66  IFDDIRPDGIKIGMLFNSEIIELVAAFLKKHARDIPIILDPVTVAKSGDPLLLPEAVDTL 125

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            ++L+P  +LITPNLPEA        A++E+EML   + LL +G   VL+KGGHL    S
Sbjct: 126 ITKLMPLATLITPNLPEAHTFTGV-DAQSEEEMLVVAQKLLDLGPQYVLLKGGHLLASTS 184

Query: 186 PDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D L  + G +  F +PRI +KNTHGTGCTLSAA+ A   ++       + AK +L +A+
Sbjct: 185 NDLLIGKNGTRHWFESPRIESKNTHGTGCTLSAAITACLAQNVEIEKACEIAKRYLFNAI 244

Query: 245 AQADTLEVGHGIGPVHHFHAWW 266
             A    VG G GPVHHF+  W
Sbjct: 245 KAAKDNSVGKGHGPVHHFYHLW 266


>UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspira
           RepID=C0R0V9_BRAHW
          Length = 269

 Score =  233 bits (594), Expect = 5e-60,   Method: Compositional matrix adjust.
 Identities = 124/265 (46%), Positives = 168/265 (63%), Gaps = 4/265 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           + ALTIAG D SGGAGIQADLKTFSALG YG  V+TAL  QNT+GV+S Y IE   +  Q
Sbjct: 2   VKALTIAGFDGSGGAGIQADLKTFSALGCYGMCVLTALPVQNTQGVRSCYEIELKAIKEQ 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN--VVLDTVMLAKSGDPLLSPSA 121
           L+ +F D+  D  KIGML  +DI++ VA+ L     +N  +++D VM+AKSGD LL   A
Sbjct: 62  LECIFDDIIPDAIKIGMLFNSDIIKLVADFLSN-NAKNIPIIVDPVMVAKSGDRLLLEEA 120

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V +L+  +LP  +++TPN+PEA  L  +   +T+ +M++    +L MG   V++KGGHL+
Sbjct: 121 VDSLKKYILPISTVVTPNIPEAEDLT-SKKIKTDDDMIDAANDILNMGAKNVMLKGGHLE 179

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            E S D    +E ++   A RI TKNTHGTGCTLSAA+ +         +  +  K +L 
Sbjct: 180 GELSRDLFINKESKEFLDALRIDTKNTHGTGCTLSAAICSYIAHGKTPLEASKLGKQYLF 239

Query: 242 SALAQADTLEVGHGIGPVHHFHAWW 266
           +AL  A    VG G GPVHHF+  W
Sbjct: 240 NALQAAKVDSVGKGHGPVHHFYEAW 264


>UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamine-phosphate
           pyrophosphorylase (Tmp pyrophosphorylase) (Tmp-ppase)
           (Thiamine-phosphate synthase); phosphomethylpyrimidine
           kinase (Hmp-phosphate kinase) (Hmp-p kinase)] n=16
           Tax=Bacteria RepID=B0RGG3_CLAMS
          Length = 752

 Score =  228 bits (581), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 135/266 (50%), Positives = 169/266 (63%), Gaps = 7/266 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDP+GGAGIQADLK+ +A G YG +V+TALVAQNT GV+ ++     F+ AQLD+
Sbjct: 265 LSIAGTDPTGGAGIQADLKSIAANGGYGMAVVTALVAQNTTGVREIHVPPVAFLRAQLDA 324

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  DV ID  KIGML    +V+ VA  L   +   VVLD VM+A+SGD LL   A   LR
Sbjct: 325 VSDDVAIDAVKIGMLGSAAVVDEVAAWLGAVRPPVVVLDPVMVAQSGDALLDADATEALR 384

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            RLLP   ++TPNLPE AALL    A   +  L QGR+L       V++KGGHL  +  P
Sbjct: 385 -RLLPLADVVTPNLPELAALLGEREADGWEAALAQGRTLATRHGVRVVVKGGHLRVDDCP 443

Query: 187 DWLFTR-EGEQRFTA-----PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D L T   G    TA     PRI T +THGTGC+LS+ALA L+PR  +W   + EAK+WL
Sbjct: 444 DALVTPGAGGAGPTAHVVDGPRIATTSTHGTGCSLSSALATLQPRRDDWRAALTEAKAWL 503

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           + +LA A+ L VG G GP+ H  A W
Sbjct: 504 TGSLAHAEDLGVGSGAGPLDHLRALW 529


>UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyrimidine
           phosphokinase) n=3 Tax=Pasteurellaceae
           RepID=Q0I130_HAES1
          Length = 270

 Score =  222 bits (565), Expect = 1e-56,   Method: Compositional matrix adjust.
 Identities = 117/260 (45%), Positives = 161/260 (61%), Gaps = 6/260 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D SGGAGIQADLKTF     +G + ITA+ AQN+ GV  ++ + P  + +QL 
Sbjct: 7   ALTIAGSDNSGGAGIQADLKTFQMQKVFGMTAITAVTAQNSLGVYDIHPVPPATIRSQLK 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D ++   KIGML   DI++ VAE L++Y    +VLD VM AK G  LL P+AV+TL
Sbjct: 67  AIAEDYQVSALKIGMLGNVDIIQCVAEELEKYDFGKIVLDPVMYAKGGAALLEPAAVSTL 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           RS LLP+  +ITPNLPE AAL D  H   +         LL MG   V++KGGH  + QS
Sbjct: 127 RSLLLPKTDVITPNLPEVAALTDI-HVVDDHTARLAAEKLLVMGVKNVVIKGGHSQNSQS 185

Query: 186 P---DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
               DWLFT+    +  +PR  T +THGTGCT SA + A   +  +    V+ AK ++S+
Sbjct: 186 EICRDWLFTQHSSLKLDSPRFDTPHTHGTGCTFSACIVAELAKGESVQSAVRTAKDFISA 245

Query: 243 ALAQADTLEVGHGIGPVHHF 262
           +++    L +GHG GP +H+
Sbjct: 246 SISHP--LNIGHGHGPTNHW 263


>UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroidales
           RepID=B6YRS2_AZOPC
          Length = 270

 Score =  221 bits (563), Expect = 2e-56,   Method: Compositional matrix adjust.
 Identities = 118/273 (43%), Positives = 171/273 (62%), Gaps = 16/273 (5%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           KR+  L++AG+DPSGGAGIQADLKT SA G YG +VITA+V +NT  V++++ I   FV 
Sbjct: 5   KRV--LSVAGSDPSGGAGIQADLKTVSACGCYGTTVITAIVDENTISVKNIHPIPISFVI 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPS 120
            Q+ SV +D+  D+ KIGML  ++++ AV      Y  I+N+VLD VM+A SGD LLS +
Sbjct: 63  GQIHSVLNDIGTDSVKIGMLYSSELIRAVRNSFLTYNTIRNIVLDPVMVATSGDFLLSNN 122

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM-----LEQGRSLLAMGCGAVLM 175
           ++ TL++  +P V ++TPN+ EA  LLD      E  +     L  GR +      +VL+
Sbjct: 123 SIDTLKNEFIPFVRVVTPNIQEAEILLDRTITNAEDFLLAVKDLSFGRKV------SVLL 176

Query: 176 KGGHLDDEQSPDWLFTREGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
           K GHL++E   D  +  E ++   F+ PRI TKNTHGTGCTLS+A+AA         D +
Sbjct: 177 KAGHLEEETLTDVFYNAETDEILYFSHPRIKTKNTHGTGCTLSSAIAAYLACGCILNDAI 236

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++A++++  A+       +G G GPVHHF  +W
Sbjct: 237 RKAETYIIQAIRVGSKYSIGKGHGPVHHFSHFW 269


>UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria RepID=B1KWX2_CLOBM
          Length = 275

 Score =  221 bits (563), Expect = 2e-56,   Method: Compositional matrix adjust.
 Identities = 112/266 (42%), Positives = 174/266 (65%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK++  L+IAG+D SGGAGIQADLKTFSA G +G SVI ++VA+NT  V  +  + PD +
Sbjct: 1   MKKV--LSIAGSDCSGGAGIQADLKTFSAHGVFGMSVIVSVVAENTSRVIDIQDVTPDMI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+D+V+ D+  D  KIGML+  D ++AV+E+LQ Y+ +N+V+D VM AK+G PL+ P+
Sbjct: 59  KSQIDAVYEDIGTDAVKIGMLSTPDCMKAVSEKLQEYKPKNIVIDPVMYAKNGCPLMDPN 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           +V+TL   ++    ++TPN+PEA   +     +T ++M +    +  MGC +VL+KGGH 
Sbjct: 119 SVSTLIESIVYHADILTPNIPEAER-ISGYKIKTLEDMEKAAGIIEGMGCKSVLIKGGHY 177

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             + + D L+       +   RI TKNTHGTGCTLS+A+A+         + V+ AK+++
Sbjct: 178 IGD-AVDVLYDGNKFYHYKTQRIHTKNTHGTGCTLSSAIASNLALGFEINEAVKRAKNYI 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           + A+    +LE+G G GP +HF+  +
Sbjct: 237 TMAIEH--SLEIGKGNGPTNHFYQVY 260


>UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsiella grylli
           RepID=A8PMT6_9COXI
          Length = 278

 Score =  216 bits (551), Expect = 5e-55,   Method: Compositional matrix adjust.
 Identities = 115/259 (44%), Positives = 165/259 (63%), Gaps = 4/259 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           ++IAGTDPSGGAGIQAD+K  SA G+Y  S+IT LVAQNT+ V S+  I  DF+  Q+D+
Sbjct: 11  VSIAGTDPSGGAGIQADIKAISATGSYAASIITVLVAQNTQAVISLQDIPLDFIQQQIDA 70

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF+D+ I+  K+GML    I+  +   L++YQ   +VLD VM+ ++G PLL P A+  L 
Sbjct: 71  VFTDLSINAVKLGMLYHEGIIRLIRHNLKKYQPPFIVLDPVMITQTGHPLLKPQAIQVLA 130

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKGGHLDDEQS 185
           + L P  +LITPN+PEA +LL+      +   +++   LLA     +VL+KGGH   + S
Sbjct: 131 TDLFPLATLITPNIPEAESLLNL--KIIDATTMQKAAVLLATRYKVSVLLKGGHSPYDAS 188

Query: 186 PDWL-FTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             +  F+++    F   RI TKNTHGTGCTLSAA+A+   +  N  + +  AK++L+  L
Sbjct: 189 DIFYDFSQKQIHYFKRARINTKNTHGTGCTLSAAIASYLAQGLNVVEAIFHAKNYLTQCL 248

Query: 245 AQADTLEVGHGIGPVHHFH 263
             A  L +G G GPV+HF+
Sbjct: 249 LAAKDLHLGQGQGPVNHFY 267


>UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI00005103C2
          Length = 288

 Score =  214 bits (546), Expect = 2e-54,   Method: Compositional matrix adjust.
 Identities = 135/274 (49%), Positives = 162/274 (59%), Gaps = 18/274 (6%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAGTDPSGGAGI ADLKTF+A G  G + ITALVAQNT GV  VY I+ DFV+ QLD
Sbjct: 8   ALSIAGTDPSGGAGIHADLKTFTARGVLGTTAITALVAQNTHGVSRVYGIDDDFVSDQLD 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SV +D+ +D TK GML    +VE V  R  + Q+    +D VM+A SG  L    AV  +
Sbjct: 68  SVLNDMPVDATKSGMLGSRSLVELVVARAAQGQLGFYTVDPVMVATSGHRLHEVDAVTAV 127

Query: 126 RSRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           R  LLP   LITPNLPEAA L+  D P A+  QEML Q R L+  G  AVL+KGGH  + 
Sbjct: 128 RDHLLPVSDLITPNLPEAALLIGDDEPVAKNPQEMLVQARQLVHRGPRAVLLKGGHAIEG 187

Query: 184 QSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAA-----LRPRHTN------WAD 231
              D L T EG    FT PR+ T NTHGTGCTLSAA+ A      R R  +        +
Sbjct: 188 DVADVLVTAEGTVTEFTHPRVETPNTHGTGCTLSAAITAEVAVLKRARAVDDVSSDLLHE 247

Query: 232 TVQEAKSWLSSALAQADTLEVGH----GIGPVHH 261
            V  A ++L+ AL  A   +V        GPV H
Sbjct: 248 AVDNALNYLARALKSAANWQVSFDPKGAHGPVDH 281


>UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella melaninogenica
           ATCC 25845 RepID=C5VH24_9BACT
          Length = 271

 Score =  214 bits (545), Expect = 2e-54,   Method: Compositional matrix adjust.
 Identities = 117/263 (44%), Positives = 166/263 (63%), Gaps = 2/263 (0%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+ I ALTIAG+D SGGAGIQAD+KT SALG Y  +VIT++  QNT+GVQ+VY + P  V
Sbjct: 1   MRYICALTIAGSDCSGGAGIQADIKTMSALGVYAAAVITSITVQNTKGVQAVYGMNPLIV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A Q+ +V  D++ D  KIGM+ +   + A+A+ L+ Y    +V+D +M++ SG  L+   
Sbjct: 61  ADQIKAVMDDIKPDAVKIGMVNDCATIHAIADTLKFYPNIPIVIDPIMISTSGFRLMKQD 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +      LLP  +L+TPNLPE A +L      T  +M    + +L++GC AVL+KGGH 
Sbjct: 121 TLELFCHSLLPMSTLLTPNLPE-AEILSNMKIYTIDDMDIAAQRILSLGCKAVLIKGGHA 179

Query: 181 DDEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             ++  D L+ T EG Q FT   I T+NTHGTGCTLS+A+ +   R  + AD +  AK++
Sbjct: 180 KGDRKVDRLYTTNEGVQTFTHKTIDTRNTHGTGCTLSSAITSFIARRLDLADAIAAAKNY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           LS AL     + +G G GPV+H 
Sbjct: 240 LSQALEAGKDIHIGEGHGPVNHL 262


>UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH
          Length = 522

 Score =  211 bits (537), Expect = 2e-53,   Method: Compositional matrix adjust.
 Identities = 116/258 (44%), Positives = 159/258 (61%), Gaps = 2/258 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LT+AG+D   GAGIQADLK  +A G Y  SVITA+ AQNTRGVQSV+ + P+F++ QL S
Sbjct: 34  LTVAGSDSGAGAGIQADLKVCAARGVYCASVITAVTAQNTRGVQSVHLLPPEFISEQLKS 93

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD   D  K GML  T+IVE + + L  + ++ +V+D VM++ SG  L   S ++  R
Sbjct: 94  VLSDFEFDVVKTGMLPSTEIVEVLLQNLSDFPVRALVVDPVMVSTSGHVLAGSSILSIFR 153

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQS 185
            RLLP   +ITPN+ EA+ALLD     T  EM    +SL  MG   VL+KGG L D   S
Sbjct: 154 ERLLPIADIITPNVKEASALLDGFRIETVAEMRSAAKSLHEMGPRFVLVKGGDLPDSSDS 213

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D  F  +      +PRI T+NTHGTGCTL++ +AA   + ++    V+ AK ++ +AL 
Sbjct: 214 VDVYFDGKEFHELRSPRIATRNTHGTGCTLASCIAAELAKGSSMLSAVKVAKRFVDNALD 273

Query: 246 QADTLEVGHGI-GPVHHF 262
            +  + +G G+ GP  HF
Sbjct: 274 YSKDIVIGSGMQGPFDHF 291


>UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31JD4_THICR
          Length = 281

 Score =  210 bits (535), Expect = 3e-53,   Method: Compositional matrix adjust.
 Identities = 109/264 (41%), Positives = 161/264 (60%), Gaps = 8/264 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+DP GGAGIQADLK+  ALG Y  + ITAL AQN++GV  V     D +  QLD+
Sbjct: 9   LSIAGSDPYGGAGIQADLKSIHALGGYALTCITALTAQNSQGVAHVVATSSDILNHQLDT 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D+++D  KIGMLA  +++  VA+++ +Y ++N+VLDTV+++ SG PLL  SA+  L+
Sbjct: 69  LLQDIKVDAVKIGMLANAELINVVADKITQYSLKNIVLDTVLISSSGHPLLEESAIECLK 128

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDEQS 185
            RL P+ ++ITPNLPE   LL        QEM     + L +G  AV+ KGGH L+ + +
Sbjct: 129 KRLFPKATIITPNLPEINHLLGTHFHGIAQEMDAIKEAFLKLGAQAVVAKGGHGLETDLA 188

Query: 186 PDWLFT-REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D L         F++PRI T +THGTGC+ S+A+A    +  +    VQ+AK  +    
Sbjct: 189 TDVLLQPNHPPMPFSSPRIQTSHTHGTGCSFSSAIATFLAQGNDLTSAVQQAKQQMHLWF 248

Query: 245 AQADTLE------VGHGIGPVHHF 262
            Q+++L+      + H   P+HH 
Sbjct: 249 GQSESLQFDYQSNLTHRKEPLHHL 272


>UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=85
           Tax=Bacilli RepID=THID_STAAS
          Length = 276

 Score =  210 bits (534), Expect = 4e-53,   Method: Compositional matrix adjust.
 Identities = 112/259 (43%), Positives = 161/259 (62%), Gaps = 5/259 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAGTDP+GGAG+ ADLK+F + G YG  V+T++VAQNT GVQ ++ +   +V  QLD
Sbjct: 7   ALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQHIHNLNHQWVDEQLD 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SVF+D      K GM+A  D +E +   L +++    V+D VMLAKSGD L+       L
Sbjct: 67  SVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNL 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLDD-E 183
           +  LLP   ++TPNLPEA  +       +E+++++ GR  +  +G   V++KGGH +D +
Sbjct: 127 QHTLLPLADVVTPNLPEAEEITGLT-IDSEEKIMQAGRIFINEIGSKGVIIKGGHSNDTD 185

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+LFT EG Q F   R  TK+THGTGCT SA + A   +     + V +AK ++S +
Sbjct: 186 IAKDYLFTNEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRRLFEAVHKAKKFISMS 245

Query: 244 LAQADTLEVGHGIGPVHHF 262
           +    T E+G G GPV+HF
Sbjct: 246 IQY--TPEIGRGRGPVNHF 262


>UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovum sp. NBC37-1
           RepID=A6Q7N2_SULNB
          Length = 270

 Score =  210 bits (534), Expect = 5e-53,   Method: Compositional matrix adjust.
 Identities = 105/247 (42%), Positives = 156/247 (63%), Gaps = 1/247 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG DP GGAG+  D+KT  ALG Y  S +TA+ AQN+ GV+SV+   P+ + AQL+ 
Sbjct: 10  LTIAGFDPYGGAGVVMDVKTIHALGGYALSSVTAVTAQNSTGVKSVHNTAPEILRAQLEV 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D+ +D  KIGMLA+ ++V+++ E +Q+Y ++N+VLDTV+++ SG  L+   AV  ++
Sbjct: 70  LLDDISVDAVKIGMLADKEVVQSIVEIIQKYDLKNIVLDTVLVSSSGRQLIREDAVEVMK 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L P V LITPN+PE   L    ++  E E  E  ++   +G  AVL+KGGH + E++ 
Sbjct: 130 KELFPLVDLITPNIPEVNTLQHHTYSGKESETQEVAQAFFDLGVNAVLLKGGHSEAEEAI 189

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L  R+G  + F   RI T +THGTGC LS+A+A    +     ++V  AK +LS  L 
Sbjct: 190 DHLVQRDGTMESFAHRRIDTTHTHGTGCLLSSAVATGLAKGLEMNESVSGAKDFLSRKLE 249

Query: 246 QADTLEV 252
            AD L++
Sbjct: 250 HADELDL 256


>UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=29
           Tax=Bacteria RepID=THIED_GEOSL
          Length = 490

 Score =  208 bits (530), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 122/262 (46%), Positives = 166/262 (63%), Gaps = 3/262 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + LT+AG+D  GGAGIQADLKT + LG+YG SV+TAL AQNTRGV  ++ + P FVA 
Sbjct: 225 RGSVLTVAGSDSGGGAGIQADLKTVTLLGSYGSSVLTALTAQNTRGVSGIHGVPPAFVAD 284

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QLD+VFSD+ +D  K GML   + + A+A +L  Y+ + VV+D VM+AK G  L+   AV
Sbjct: 285 QLDAVFSDIPVDVVKTGMLFSAETIVAIAAKLTEYRRRMVVVDPVMVAKGGANLIDRGAV 344

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           + L+ RL P   L+TPN+PEA  L  A +   E+ M E  R L  +G   VL+KGGHL  
Sbjct: 345 SVLKERLFPLAYLVTPNIPEAERLTGA-NISDEESMREAARRLHRLGARNVLLKGGHLLA 403

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
             S D LF      RF +PRI++KNTHGTGCT ++A+A    +     + +  AK ++++
Sbjct: 404 GDSVDILFDGAAFHRFVSPRILSKNTHGTGCTFASAIATYLAQGDPLREAIARAKRYITA 463

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+  A  L  GH  GPV+H  A
Sbjct: 464 AIRLAQPLGRGH--GPVNHILA 483


>UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria RepID=B0KBA9_THEP3
          Length = 264

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 113/257 (43%), Positives = 165/257 (64%), Gaps = 4/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLKTFSA G YG SVIT++ AQNT GV  +  I PD V  Q+ 
Sbjct: 4   ALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMK 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++F D+  D  KIGM++   I++ +A+ L+ Y ++N+VLD VM++KSG  LL P AV  L
Sbjct: 64  AIFEDLYPDAVKIGMVSNESIIKMIAKGLKDYNVKNIVLDPVMISKSGSYLLKPEAVEAL 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +  L+P   ++TPNL EA  L+     +   +M E  + +L  G   V++KGGHL  + +
Sbjct: 124 KKELIPLSLVVTPNLMEAGELI-GKEIKNVSDMKEAAKKILDYGAKTVIVKGGHLTGD-A 181

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D  +  +     T+ RI TKNTHGTGCT S+A+AA      +  ++++ AK++++ A+ 
Sbjct: 182 LDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAIK 241

Query: 246 QADTLEVGHGIGPVHHF 262
              +L +GHG+GP +HF
Sbjct: 242 H--SLAIGHGVGPTNHF 256


>UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Flavobacteriaceae
           RepID=Q1VWC4_9FLAO
          Length = 269

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 103/246 (41%), Positives = 155/246 (63%), Gaps = 3/246 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+K+  A GAY  ++ITA+ AQNT GV ++  + P  +A QL +V  D+  D  KIG
Sbjct: 21  IQADIKSAGACGAYSATIITAITAQNTLGVNAIEGVSPQMIANQLTAVMDDIGADALKIG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +++E VA+ LQ Y+ +++VLD VM+A SGDPLL   A+  L  +++PQ  +ITPN
Sbjct: 81  MLHSKEVIEEVAKHLQHYKAKHIVLDPVMVATSGDPLLQEDAIQALMHQIIPQAEVITPN 140

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQ--R 197
           +PE   LL     +   E  +  R+L      +VL+K GHL  ++S D LF  + +Q  +
Sbjct: 141 VPEMELLL-GETIKNTTEFSDYARALAEKFKVSVLLKAGHLKGDKSVDILFNVKTKQITK 199

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
            ++PRI TKNTHGTGC+LS+ALA+   +  +  D  Q+AK+++  A+      ++G G G
Sbjct: 200 LSSPRITTKNTHGTGCSLSSALASYLAQGFSLEDASQKAKTFIYQAIKAGGDYKLGKGSG 259

Query: 258 PVHHFH 263
           P+HHF+
Sbjct: 260 PIHHFY 265


>UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Corynebacterium amycolatum
           SK46 RepID=UPI000185BF73
          Length = 537

 Score =  204 bits (520), Expect = 2e-51,   Method: Compositional matrix adjust.
 Identities = 116/258 (44%), Positives = 162/258 (62%), Gaps = 2/258 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDP+GGAG+ ADLK+ +A G YG  V+TALV+QNT GV++V+    DF+  QL +
Sbjct: 16  LSIAGTDPTGGAGLHADLKSIAAAGGYGMGVVTALVSQNTVGVRAVHTPPVDFLVEQLAA 75

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  DV ID  KIGML   ++ +AV   ++  +   VVLD VM+A SGD LL   A+  +R
Sbjct: 76  VTEDVTIDAVKIGMLGSRELTQAVTNWVRETKPAVVVLDPVMVATSGDRLLDEDAMDAMR 135

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L+ + ++ITPN+PE A L DAP A    E++EQ     +     V+ K GHL DE++ 
Sbjct: 136 D-LVTEATVITPNVPELALLADAPEASDFTELIEQALEFASENDVIVIAKTGHLSDEEAG 194

Query: 187 DWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           + +   +G+  F ++PRI T+NTHGTGC+LSAALA      +   D ++    WLS ++ 
Sbjct: 195 NAVAFPDGQVFFSSSPRIHTENTHGTGCSLSAALATRIGGGSAINDALRWTTRWLSESIR 254

Query: 246 QADTLEVGHGIGPVHHFH 263
            AD L VG G GP+ H H
Sbjct: 255 FADNLNVGQGHGPIDHGH 272


>UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenhoekiella blandensis
           MED217 RepID=A3XJN4_9FLAO
          Length = 277

 Score =  202 bits (513), Expect = 1e-50,   Method: Compositional matrix adjust.
 Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG D SGGAGIQADLKT SALG Y  +V+TAL  QNT GVQS++ I    V  QLDS
Sbjct: 10  LSIAGFDGSGGAGIQADLKTISALGCYATTVLTALPVQNTTGVQSIFSIPTSVVKEQLDS 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +F D++    KIGM+   ++VE +A +L+ Y    VV D VM+A SG  L+    + ++ 
Sbjct: 70  IFDDIQPSAIKIGMVHTPELVETIAAKLKNYPKIPVVFDPVMVATSGHKLIEDETIKSIT 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L P   +ITPN+ EAA L   P   T ++M   G  +L + C +VL+KGGHL  +   
Sbjct: 130 ELLFPLADVITPNMDEAAILAQMP-VETIEDMRIAGNKILDLSCKSVLLKGGHLKSDLLT 188

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
              F  +     F   +  T+N HG+GCTLS+A+A+   +  +  ++V +A+ ++  A+ 
Sbjct: 189 SLFFGPDKTVDEFEFEKFETQNMHGSGCTLSSAIASFLAQKNSLLNSVTKAQEYVHQAIY 248

Query: 246 QADTLEVGHGIGPVHHF 262
            A  +++G G GP++HF
Sbjct: 249 HAKEVKIGKGNGPLNHF 265


>UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KLG7_9FIRM
          Length = 268

 Score =  201 bits (511), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 120/264 (45%), Positives = 164/264 (62%), Gaps = 10/264 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK++  LTIAG+D SGGAG+QADLKT  A G YG S ITAL AQNT+GV+ V    P+F+
Sbjct: 1   MKKV--LTIAGSDSSGGAGVQADLKTMLANGVYGMSAITALTAQNTQGVRMVQEATPEFL 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AA+LD+VF D+R D  K+GM+A   ++  +A++L+ Y+ ++VV+D VM+A SG  LL   
Sbjct: 59  AAELDAVFEDIRPDAVKVGMVASPALIHVIADKLKAYKAEHVVVDPVMVATSGAKLLVDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGA-VLMKGGH 179
           A+  L   L P   +ITPN+PE + L  A  A  ++   EQ    LA      VL KGGH
Sbjct: 119 AIEVLVQELFPLAEVITPNIPELSVLTGAEIA--DEFAFEQAAKKLAAEAEVNVLAKGGH 176

Query: 180 LDDEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
             D+ S D L     EGEQ +   R+   NTHGTGCTLS+A+AA   +  +  +++  AK
Sbjct: 177 FADDAS-DLLVLAGGEGEQWYRGTRVANPNTHGTGCTLSSAIAANLAKGFDLDESIGRAK 235

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
           S+L  AL     +++G G GPV H
Sbjct: 236 SYLFGALLA--KMDLGRGNGPVDH 257


>UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinibacter turnerae
           T7901 RepID=C5BTK8_TERTT
          Length = 274

 Score =  201 bits (511), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 115/259 (44%), Positives = 161/259 (62%), Gaps = 2/259 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+DP GGAG+QAD+KT +ALG Y C+V TAL AQN+RGV +V+ + P+ + AQ  +
Sbjct: 9   LAIAGSDPLGGAGLQADIKTAAALGGYCCTVTTALTAQNSRGVSAVWPVAPEQLRAQFSA 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+     K+GML    ++  +A  L+      VVLD V+ A +G  LLS +A   L 
Sbjct: 69  VTEDITPGAIKVGMLGNAALIAELANLLRTQPNVPVVLDPVLAATAGGDLLS-NASGELV 127

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           ++LLP+V+L+TPNL EA+ LL+ P A  E +ML Q ++L  MG  AVL+KGGHL   ++ 
Sbjct: 128 AQLLPRVTLLTPNLHEASRLLNCPPALDESDMLVQAKALREMGPRAVLIKGGHLASSRAI 187

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L +     QRF +PR+  +NTHGTGCTL+ A+A            V  AK ++  A+A
Sbjct: 188 DILLSETNTVQRFASPRLAARNTHGTGCTLATAIATGLAAGHALPVAVACAKRFIQQAIA 247

Query: 246 QADTLEVGHGIGPVHHFHA 264
            AD+L +    GP+ HF A
Sbjct: 248 HADSLNLVDENGPLQHFFA 266


>UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroides
           RepID=Q5LCW2_BACFN
          Length = 277

 Score =  201 bits (510), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 110/256 (42%), Positives = 156/256 (60%), Gaps = 1/256 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+D SGGAGIQAD+KT SALGAY  SVITA+  QNTRGV++V+ +  + V  Q+++
Sbjct: 8   LSIAGSDCSGGAGIQADIKTISALGAYAASVITAVTVQNTRGVKAVHTVPAEIVQGQIEA 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+R D  KIGM++E  +V+ +A  L +Y    +V D VM++ SG  L++  A+  ++
Sbjct: 68  VMEDLRPDALKIGMVSEPALVKIIAGCLLKYPHCPIVYDPVMVSTSGRKLMAKDAIQLIK 127

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L P  SLITPNL E   +L      T +EM E  R L      AVL+KGGHL+  +  
Sbjct: 128 EELFPLTSLITPNLDE-TEVLTGKKITTAEEMKEAARQLSEEYHTAVLVKGGHLEGNEMQ 186

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D LFT      +   +I ++N HGTGCTLS+++A            V +AKS++S A+  
Sbjct: 187 DVLFTDGNAYIYKEKKIESRNLHGTGCTLSSSIATYLALGLPMDQAVGKAKSYVSKAIDA 246

Query: 247 ADTLEVGHGIGPVHHF 262
              + +GHG GP+ HF
Sbjct: 247 GKEIIIGHGNGPLCHF 262


>UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingobacterium
           spiritivorum RepID=C2FVP8_9SPHI
          Length = 278

 Score =  201 bits (510), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 107/260 (41%), Positives = 155/260 (59%), Gaps = 2/260 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  L+IAG D SGGAGIQAD+KTFSALG Y  SV+TAL  QNT+GV+S+Y I    V  Q
Sbjct: 8   IPVLSIAGFDGSGGAGIQADMKTFSALGCYATSVLTALPVQNTQGVRSIYPIPDVAVREQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + ++  D+     KIGM+  +++V+ + + L  Y    VV D VM+A SG  L+  S + 
Sbjct: 68  IQTILDDIFPKAIKIGMVHTSELVQIITDTLGLYPATPVVFDPVMVATSGHKLIEESTIL 127

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           TL  +L P  +++TPN+ EAA L +    +T  +M   G  +L +GC +VL+KGGHL   
Sbjct: 128 TLVEQLFPITTVLTPNMDEAAILAEM-EVKTLDDMYIAGEKILKLGCQSVLLKGGHLQTS 186

Query: 184 QSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
                 F + G  Q F   +  T NTHG+GCTLS+A+A+   R  + AD V+  + ++  
Sbjct: 187 MLTSLFFDQSGSVQTFEFEKFETNNTHGSGCTLSSAIASYLARGESLADAVRLGQDYVHQ 246

Query: 243 ALAQADTLEVGHGIGPVHHF 262
           A+     ++ G G GP++HF
Sbjct: 247 AILNGKDVQTGKGNGPLNHF 266


>UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebacterium
           RepID=C5VF19_9CORY
          Length = 730

 Score =  200 bits (509), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 126/265 (47%), Positives = 157/265 (59%), Gaps = 13/265 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDP+GGAG QADLK+ +A G YG + ITALVAQNT GV+S++     F+  QLD+
Sbjct: 232 LSIAGTDPTGGAGAQADLKSIAAAGGYGMNAITALVAQNTHGVRSIHTPPLSFLREQLDA 291

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SDV ID  KIGML   DIV  V + L  + +  VVLD VM+A SGD LL P A   + 
Sbjct: 292 VVSDVTIDAVKIGMLGSADIVACVRQWLAEHPMPLVVLDPVMVATSGDRLLDPDAEQAV- 350

Query: 127 SRLLPQVSLITPNLPEAAALLDAPH-ARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
                 V ++TPN+PE A LL AP  ART +E L Q           V+ KGGHLD + +
Sbjct: 351 IEFAHHVDIVTPNVPELAVLLSAPEPARTFEEALSQAAEFAQKSNTIVIAKGGHLDGKLA 410

Query: 186 PDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            + +   +G     T PRI T NTHGTGC+LS+ALA          DT+ EA  W+S  L
Sbjct: 411 NNAVVYPDGRITTITTPRIDTTNTHGTGCSLSSALAT----RLAAGDTITEAIEWVSYWL 466

Query: 245 AQA----DTLEVGH--GIGPVHHFH 263
           A +      LEVG   G GP+ HFH
Sbjct: 467 ADSIRAGAALEVGTPGGHGPIDHFH 491


>UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli RepID=Q5HMC8_STAEQ
          Length = 273

 Score =  200 bits (509), Expect = 4e-50,   Method: Compositional matrix adjust.
 Identities = 111/259 (42%), Positives = 156/259 (60%), Gaps = 5/259 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAGTDP+GGAG+ ADLK+F A G YG + IT++VAQNT GVQ ++ +E  +V  QLD
Sbjct: 7   ALTIAGTDPTGGAGVMADLKSFHACGVYGMATITSIVAQNTLGVQHIHNLESSWVKEQLD 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SVF D      K GM+A    +E +   L+ +     V+D VMLAKSGD L+  +    L
Sbjct: 67  SVFDDELPQAIKTGMIATKKTMELIQSYLKEHSNIPYVIDPVMLAKSGDSLMDENTKNHL 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLDD-E 183
           +S LLP   ++TPN+PEA  +        E+ + + G+  +  +G   V++KGGH  D  
Sbjct: 127 QSTLLPLADVVTPNIPEAEEIT-GIKINDEESIRKAGQIFINEIGSKGVVIKGGHSADLN 185

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+LFT+     F   R  TK+THGTGCT SA + A   +  +  D V++AK ++S  
Sbjct: 186 NAKDFLFTKNETYTFENKRFDTKHTHGTGCTFSAVITAELAKGRSIKDAVKKAKEFIS-- 243

Query: 244 LAQADTLEVGHGIGPVHHF 262
           L+   T E+G G GPV+HF
Sbjct: 244 LSIEHTPEIGKGRGPVNHF 262


>UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular organisms
           RepID=A8MBV4_CALMQ
          Length = 436

 Score =  200 bits (508), Expect = 5e-50,   Method: Compositional matrix adjust.
 Identities = 115/262 (43%), Positives = 164/262 (62%), Gaps = 5/262 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +K   ALTIAG D  GGAGI ADLKTF A+G YG   +TA+ AQNT GV++V  IEP  V
Sbjct: 3   VKLPKALTIAGLDSGGGAGITADLKTFHAMGVYGMVALTAVTAQNTLGVKAVQEIEPSIV 62

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+++V  D+ +D  K GML+ + I+E+VA+ ++R+    +V+D VM AKSGDPL+   
Sbjct: 63  EAQINAVAEDIGVDAAKTGMLSSSPIMESVAKVVRRWGFP-LVVDPVMYAKSGDPLMRQD 121

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TLR  ++P   ++TPN+PEA AL                R         V++KGGHL
Sbjct: 122 AIDTLRRTIIPLAKVVTPNIPEAEALSGVSIRNLNDAKAAAKRIAEEFHPEIVIVKGGHL 181

Query: 181 DDEQSPDWLFTRE-GEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
              +S D ++ R+ GE R  +APRI T NTHGTGC+ SAA+AA   +  +  D++++AK 
Sbjct: 182 TGAESIDVVYFRDNGEYRELSAPRISTGNTHGTGCSFSAAIAAGLAKGMSPWDSIKQAKE 241

Query: 239 WLSSALAQADTLEVGHGIGPVH 260
            ++ A+    +L +GHG GPV+
Sbjct: 242 LITMAIQY--SLPLGHGHGPVN 261


>UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntrophomonas wolfei subsp.
           wolfei str. Goettingen RepID=Q0AZ88_SYNWW
          Length = 290

 Score =  199 bits (507), Expect = 7e-50,   Method: Compositional matrix adjust.
 Identities = 123/276 (44%), Positives = 159/276 (57%), Gaps = 18/276 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++I  LTIAG+D   GAGIQAD+KT  ALGAY  SVITA+ AQNTR V +V  IE   +
Sbjct: 1   MRKI--LTIAGSDSCAGAGIQADIKTIQALGAYALSVITAVTAQNTRQVTAVREIEALVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY---------QIQN---VVLDTVM 108
             QL+++FSD+R+D  KIGML     V+AV+  L  +         Q++N   +V+D VM
Sbjct: 59  EKQLEAIFSDIRLDGIKIGMLGRAGTVQAVSNFLASFFQAGAFWEKQLKNSLPLVVDPVM 118

Query: 109 LAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAM 168
           +AKSGD LL   AV +L+  LLP  S+ITPNL EA ALL    +  E EM E  R LL  
Sbjct: 119 IAKSGDRLLEEEAVESLKKNLLPLASVITPNLMEAGALLGREISSLE-EMKEAARELLEF 177

Query: 169 GCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
           GC   ++KGGHL  E   D L  ++        R+ T   HGTGCT SAALA L  +   
Sbjct: 178 GCQWAIVKGGHLKGE-PVDVLANKDSLYLLRGQRVDTNCNHGTGCTFSAALATLMGQGLA 236

Query: 229 WADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
                + AK+++   L       +G G+G  HHF A
Sbjct: 237 VPAAAKRAKAYVEYCLEHG--FAIGEGVGIPHHFAA 270


>UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantella formatexigens DSM
           14469 RepID=C6LBN3_9FIRM
          Length = 330

 Score =  197 bits (502), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 119/305 (39%), Positives = 160/305 (52%), Gaps = 53/305 (17%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGIQADLKT  A   YG SVITAL AQNT GV  +    P+FVA Q+D 
Sbjct: 6   LTIAGSDCSGGAGIQADLKTMMAHDVYGMSVITALTAQNTTGVYGILETPPEFVAQQIDC 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF D+R D  KIGM+ +  I+E +AE+L++YQ +N+V+DTVM++ SG  L+S  A+ T  
Sbjct: 66  VFQDIRPDAVKIGMVPDCGIMEVIAEKLKQYQAENIVIDTVMISTSGHRLMSEQAMQTYT 125

Query: 127 SRLLPQVSLITPNLPEAAALLDAP------------------------------------ 150
            +LLP  ++ITPNLPEA AL                                        
Sbjct: 126 EKLLPLAAVITPNLPEAEALYQYETGAGIRAEKGSYQNETGAGIRAEKGSYQNETGAGIR 185

Query: 151 --------------HARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQ 196
                         HA +E++M      +     GA+L+KGGHL  + + D L       
Sbjct: 186 AEKGSFQNETGAGFHAGSEEDMKRMAEKIAGRYGGALLIKGGHLCGD-AADLLCENGNFH 244

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
            F   RI   N+HGTGCTLS+A+A    +     ++V  AK +++ AL     L +G G 
Sbjct: 245 WFRTERIQNPNSHGTGCTLSSAIACNLAKGKTVYESVYAAKEYVTDALRAG--LNLGRGS 302

Query: 257 GPVHH 261
           GP+ H
Sbjct: 303 GPLAH 307


>UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM
          Length = 269

 Score =  197 bits (500), Expect = 4e-49,   Method: Compositional matrix adjust.
 Identities = 115/258 (44%), Positives = 160/258 (62%), Gaps = 6/258 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKTF   G +G SVITA+ AQNT GV  ++ I    + AQL +
Sbjct: 7   LTIAGSDSGGGAGIQADLKTFQMRGVFGTSVITAVTAQNTLGVFDIHPIPLASIQAQLRA 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D  I   KIGML  T+I++ VA+ L++YQ  ++VLD VM+AK G  LL  SAVA L+
Sbjct: 67  VAKDFSISAVKIGMLGNTEIIQCVADCLEQYQFSHIVLDPVMIAKGGATLLEQSAVAALK 126

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS- 185
           + +LP+  LITPN+PEA   +     + E ++    +    +G   V++KGGH ++ QS 
Sbjct: 127 NLILPKACLITPNIPEAER-ITGTQIKNEADIFNAAQIFHELGANTVVIKGGHHNNSQSK 185

Query: 186 --PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              DW+FT++G     APR  T +THGTGCT SA L A   +       V+ AK+++++A
Sbjct: 186 LCKDWVFTQKGYFTLEAPRFATPHTHGTGCTFSACLTAELAKGKPVEQAVRTAKNYITAA 245

Query: 244 LAQADTLEVGHGIGPVHH 261
           +     L +GHG GP +H
Sbjct: 246 IGHP--LNIGHGHGPTNH 261


>UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=5
           Tax=Bacteroidales RepID=A6LAW4_PARD8
          Length = 282

 Score =  196 bits (497), Expect = 8e-49,   Method: Compositional matrix adjust.
 Identities = 109/258 (42%), Positives = 160/258 (62%), Gaps = 2/258 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQAD+KTFS+LG +G S ITA+ AQNT+GV+ +  I P+ +  Q++
Sbjct: 12  ALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILRGQIE 71

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D  +D  KIGML   D V+ V+E L  ++  +++LD VM++ SG  LL   A+ T+
Sbjct: 72  AILEDFIVDAVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDAIRTI 131

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
              L P+ +L+TPN+PE    L       E ++L   R L   GC A+L+KGGH+   ++
Sbjct: 132 MDELFPKATLLTPNIPE-TEYLSGIKINNEADILCAARKLQEKGCNAILIKGGHIPGVET 190

Query: 186 PDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D LF  E       +P + T NTHGTGCTLS+A+AA      +  + V+ AK ++++AL
Sbjct: 191 VDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVRLAKEYMNNAL 250

Query: 245 AQADTLEVGHGIGPVHHF 262
                + +G G GPV+HF
Sbjct: 251 VHGANVCMGKGHGPVNHF 268


>UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 cluster
           RepID=Q1V215_PELUB
          Length = 270

 Score =  195 bits (495), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 97/256 (37%), Positives = 154/256 (60%), Gaps = 3/256 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+D SGGAGIQAD+KT +ALG+Y  + ITA+  QNT GV+S+  I+P  ++ Q++ 
Sbjct: 8   LVIAGSDSSGGAGIQADIKTITALGSYAMTAITAVTIQNTTGVKSIVPIDPKEISNQIEF 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
              D++ D  KIGML  T ++++V   L   +++ ++LD VM+AK G  L+   A+  L+
Sbjct: 68  TSKDIKPDAIKIGMLHSTKVIKSVIHSLNLIKVKKIILDPVMVAKGGAKLIDDKAIQLLK 127

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           + L+ +VSLITPN+PE A +L     RT+++M+     L+ +G   V +KGGHL+ +   
Sbjct: 128 NELIKKVSLITPNIPE-AEILTKTKIRTKEDMIFAASILIKLGAKNVFIKGGHLESKIVQ 186

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D    +         RI T+NTHGTGCTLS+A++           + + A  ++ +++  
Sbjct: 187 DIFVNKNEIFIIKNKRITTRNTHGTGCTLSSAISTFFSCGKTLKRSCELATKYVHNSINS 246

Query: 247 ADTLEVGHGIGPVHHF 262
              L+ G G GP++H 
Sbjct: 247 --NLKFGKGHGPINHL 260


>UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=18
           Tax=Actinomycetales RepID=THIED_CORGL
          Length = 763

 Score =  194 bits (492), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 115/258 (44%), Positives = 156/258 (60%), Gaps = 2/258 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDP+GGAGIQADLK+ +A G YG  V+T+LVAQNT GV +++     F+  QL++
Sbjct: 245 LSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTSLVAQNTHGVNTIHTPPLTFLEEQLEA 304

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VFSDV +D  K+GML   D V+ VA  L  ++   VVLD VM+A SGD LL  SA  +LR
Sbjct: 305 VFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLR 364

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            RL   V ++TPN+PE A L D+  A T  E + Q +         V++KGGHL    + 
Sbjct: 365 -RLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGALAD 423

Query: 187 DWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           + +   +G   +    R+ T N+HGTGC+LSA+LA       +    ++ +  WL+ AL 
Sbjct: 424 NAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATKIAAGESVEKALEWSTRWLNEALR 483

Query: 246 QADTLEVGHGIGPVHHFH 263
            AD L VG G GPV H H
Sbjct: 484 HADHLAVGTGNGPVDHGH 501


>UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomonas sputigena ATCC
           35185 RepID=C9LV61_9FIRM
          Length = 296

 Score =  194 bits (492), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 113/267 (42%), Positives = 159/267 (59%), Gaps = 9/267 (3%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK I   LTIAG+DPSGGAGIQAD+KT +A   Y  ++ TAL  QNT G++  + I PDF
Sbjct: 34  MKDIRKVLTIAGSDPSGGAGIQADIKTITAHKMYAMNISTALTVQNTTGIRDTFVIPPDF 93

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +A QLD+++ D+R D  KIGM+A   IV  +AE+L+    +N+VLD V+ + SG  L++ 
Sbjct: 94  IAEQLDAIYDDIRPDAVKIGMVANDAIVHTIAEKLREKDAKNIVLDPVIASTSGCDLITS 153

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +  +   LLP V ++TPNLPEAAA+        E  ML+  + L      AVL+KGGH
Sbjct: 154 DTLFAMVDELLPLVDIVTPNLPEAAAITGVA-ITDEDSMLKAAKVLTERFPIAVLIKGGH 212

Query: 180 LDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L   +S D L   +G+ R +   RI  +NTHGTGC LS A+A            V++AK+
Sbjct: 213 L--VESADDLLYADGKARWYKQTRIDNENTHGTGCALSTAIACGLAAGKPLTIAVEDAKA 270

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           +++ A+     L +G G GP+   H W
Sbjct: 271 YITGAIRAG--LNIGKGRGPL--LHMW 293


>UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria RepID=A7I3E2_CAMHC
          Length = 257

 Score =  193 bits (491), Expect = 4e-48,   Method: Compositional matrix adjust.
 Identities = 107/260 (41%), Positives = 158/260 (60%), Gaps = 7/260 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  LTIAG+D SGGAGI+AD+KTF A G YG SVIT++VA+NT  V + Y +    V  Q
Sbjct: 2   IPVLTIAGSDASGGAGIEADIKTFCAHGLYGMSVITSVVAENTFRVINAYDMSAQAVGDQ 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +++VF D+     KIGML   +I++ VAE+L ++  +NVVLD VM AK+G  L+S     
Sbjct: 62  IEAVFEDIVPKAVKIGMLPNAEIMQIVAEKLAKFSAKNVVLDPVMQAKNGFNLMSER--E 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L S++L  + +ITPN+PEA  L +      E +M      +   G  +VL+KGGH +  
Sbjct: 120 NLLSKMLGVIDIITPNIPEAEILTNT-EISNENDMKNAALIIAKKGAKSVLIKGGHKNG- 177

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+L+       +    I TKNTHGTGCTLS+A+A+         + V+ AK ++   
Sbjct: 178 -TSDFLYFEGKFFEYKTKFINTKNTHGTGCTLSSAIASNLALGRKMNEAVENAKKYIQGT 236

Query: 244 LAQADTLEVGHGIGPVHHFH 263
           +   ++L++GHG GP++HF+
Sbjct: 237 I--ENSLDLGHGAGPLNHFY 254


>UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria RepID=A1W069_CAMJJ
          Length = 270

 Score =  193 bits (491), Expect = 5e-48,   Method: Compositional matrix adjust.
 Identities = 108/263 (41%), Positives = 157/263 (59%), Gaps = 4/263 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  LTIAG+D SGGAGIQADLKTFSA   +G SV+ ++VA+NT  V SV+ I    V  Q
Sbjct: 9   IPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQ 68

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +VF D+    TKIGM+   +++  VA+ L  ++ QNVV+D VM AK+G  L+      
Sbjct: 69  MLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCD 128

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
             +  ++    ++TPN+PEA  L     A  EQ M++  + L ++G  AVL+KGGH  +E
Sbjct: 129 FFKQTIVKFADILTPNIPEAEFLCGFKIANEEQ-MIKAAKHLCSLGAKAVLLKGGH-SEE 186

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L+  +        RI TKNTHGTGCTLS+A+A+   +  +    V EAK ++ +A
Sbjct: 187 NANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFYAVSEAKEYVRNA 246

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           +    +L +G G GP +HF  + 
Sbjct: 247 IYY--SLNLGKGCGPTNHFFKFL 267


>UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria RepID=A1WTB6_HALHL
          Length = 271

 Score =  192 bits (487), Expect = 1e-47,   Method: Compositional matrix adjust.
 Identities = 113/243 (46%), Positives = 148/243 (60%), Gaps = 3/243 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLK   ALG Y C+ ITAL AQNT+GVQ V+ + P F+ AQ+ SV +D+  D  K G
Sbjct: 24  IQADLKAVMALGGYCCTAITALTAQNTQGVQDVHTVPPGFIRAQIRSVLTDIGADCVKTG 83

Query: 80  MLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML +T +++AVA  L        +V+D VM+A+SGD LL+ +A   L   LLP+ +L+TP
Sbjct: 84  MLHDTAVIDAVAAELDALAPGVPLVVDPVMVAQSGDRLLAEAAAERLGDVLLPRATLLTP 143

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRF 198
           NLPEA  LL      TE  + E  R+L   G  AVL+KGGH   ++  D L T EGE  F
Sbjct: 144 NLPEAEVLLGRSVPATESGLQEAARALRGYGAEAVLVKGGHAPGDEVIDCLATPEGEVCF 203

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            + RI T + HGTGCTL++A+AA   R    +D V  A+ +L  AL  A  L  G G GP
Sbjct: 204 RSRRIETNSNHGTGCTLASAIAAGVARGLPLSDAVPHARDYLQEALRTARGL--GGGAGP 261

Query: 259 VHH 261
           V+H
Sbjct: 262 VNH 264


>UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Meiothermus silvanus DSM 9946 RepID=C1XR49_9DEIN
          Length = 278

 Score =  191 bits (484), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 115/257 (44%), Positives = 157/257 (61%), Gaps = 4/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALT+AG+DPSGGAG+QADLKTF   G YG  V+T L  QNT GV+ V  +EP  VA QL+
Sbjct: 18  ALTVAGSDPSGGAGLQADLKTFHRFGVYGMGVVTVLTVQNTLGVREVVPLEPALVARQLE 77

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D      K G L +  IV ++A  L +  +  +V+D V++AKSGD LL   A+  L
Sbjct: 78  AVLHDPGAHAIKTGALGDAAIVHSIAPLLAQAALP-LVVDPVLVAKSGDSLLGGEALEAL 136

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +S LLP  +L+TPNL EA ALL  P  R   +  E  R L  +G  AVL+KGGHL  +++
Sbjct: 137 KSCLLPIAALLTPNLLEAQALLGQP-IRDLADAREAARLLACLGPRAVLLKGGHLAGKEA 195

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L+       F   +I + +THGTGCTLSAA+ AL  +     + V  AK +++ A+A
Sbjct: 196 TDVLWDGHALHLFPEWKIPSVHTHGTGCTLSAAITALLAKGIPLHEAVARAKRFVTRAIA 255

Query: 246 QADTLEVGHGIGPVHHF 262
            A    +G GIGP++H+
Sbjct: 256 TAPG--IGRGIGPLNHW 270


>UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria RepID=A1A2J4_BIFAA
          Length = 280

 Score =  189 bits (480), Expect = 8e-47,   Method: Compositional matrix adjust.
 Identities = 119/276 (43%), Positives = 159/276 (57%), Gaps = 22/276 (7%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+D SGGAGIQADLKT  A G +G + I AL AQNT GV  V    P+ +AAQ+D+
Sbjct: 9   LSIAGSDSSGGAGIQADLKTMLANGVFGMTAIAALTAQNTTGVTMVTNTPPEMLAAQIDA 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF D+     KIGM++  +++  +A+RL  +  +NVVLD VM+A SG  L+   A+A L 
Sbjct: 69  VFEDIPPVAVKIGMVSSAELITVIADRLTAHNAKNVVLDPVMVATSGAKLIEDDAIAALT 128

Query: 127 SRLLPQVSLITPNLPEAAALLD--------------APHARTEQEMLEQGRSLLA-MGCG 171
           S+L P  ++ITPN+PE   L D                   TE +M+  G  L    GC 
Sbjct: 129 SKLFPLATVITPNMPETQVLCDLAVEQGAGAIDYENGESISTENDMVTAGHLLAGHFGC- 187

Query: 172 AVLMKGGHLDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWA 230
           AVL+KGGH   + S D L   +G+   F + RI   NTHGTGCTLS+A+A+         
Sbjct: 188 AVLVKGGHGTHDAS-DVLVEPDGKITWFRSRRINNPNTHGTGCTLSSAIASHLALGEALP 246

Query: 231 DTVQEAKSWLSSAL-AQADTLEVGHGIGPVHHFHAW 265
             V  AK +L+ AL AQ   L++GHG GP+ H   W
Sbjct: 247 TAVDHAKLYLTGALEAQ---LDLGHGSGPMDHAWKW 279


>UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillales
           RepID=C6D361_PAESJ
          Length = 275

 Score =  189 bits (479), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 116/257 (45%), Positives = 159/257 (61%), Gaps = 3/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLKTF  LGAYG S +TA+ AQNT GVQ V+ +  + V AQ+ 
Sbjct: 12  ALTIAGSDSGGGAGIQADLKTFQELGAYGMSALTAITAQNTLGVQGVFPLAKEAVKAQIH 71

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SV SD+ +D  K GML   +I+E VAE +  +  + VV+D VM+AK G  LL   AV  L
Sbjct: 72  SVGSDIGVDALKTGMLFSAEIIEEVAEAIAFFGWKKVVVDPVMIAKGGASLLQVEAVRAL 131

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
             +LLP   +ITPN+PEA  L      R + + LE  + L ++G   VL+KGGH     +
Sbjct: 132 SRKLLPLTMIITPNIPEAEHLTGMA-IRNKNDKLEAAKKLSSLGARYVLIKGGHEAGADA 190

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L+   G    +  RI+T+ THGTGCT SAAL A   +  +  + V++AK+++ +A+ 
Sbjct: 191 VDLLYDGSGYSELSGKRIVTERTHGTGCTYSAALTAGLAQGLDIEEAVRQAKAYIQAAI- 249

Query: 246 QADTLEVGHGIGPVHHF 262
             D + VG G GP +H+
Sbjct: 250 -EDGIIVGSGHGPTNHW 265


>UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=B4RNJ4_NEIG2
          Length = 288

 Score =  188 bits (478), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 105/245 (42%), Positives = 145/245 (59%), Gaps = 6/245 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF   G +G  VITA+ AQNT GV +V+ +  + + AQ+ ++  D  I   KIG
Sbjct: 42  IQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKIG 101

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA++L+       VLD VM+AK G PLL  SAVA L   LLP   ++TPN
Sbjct: 102 MLGTAEIIECVADKLKHCSFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDILTPN 161

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS---PDWLFTREGEQ 196
           LPEA AL    H    ++     + LL  G   V++KGGHL+   S    DWLFT+    
Sbjct: 162 LPEAEALTGV-HIENRKDAERAAKILLDYGVKNVIIKGGHLNGSTSGRCTDWLFTQNETL 220

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
              +PR  T +THGTGCT SA + A   +  +    VQ AK+++++A+  ++ LE+G G 
Sbjct: 221 ELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVQTAKAYITAAI--SNPLEIGAGH 278

Query: 257 GPVHH 261
           GPV+H
Sbjct: 279 GPVNH 283


>UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptococcus agalactiae
           RepID=Q3D6X9_STRAG
          Length = 265

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 116/257 (45%), Positives = 156/257 (60%), Gaps = 7/257 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAGTDPSGGAGI ADLKTF A   YG +V+T++VAQNT GV+ V  IE   +  QL  
Sbjct: 8   LTIAGTDPSGGAGIMADLKTFQARRTYGMAVVTSVVAQNTCGVRGVQHIETAIIDQQLAC 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V+ D++    K GMLAE + +  VA  L++Y  Q  VLD VM+A SG  L+   AV  L+
Sbjct: 68  VYDDIKPKAVKTGMLAERETISLVASYLKKYP-QPYVLDPVMVATSGHRLIDSDAVEALK 126

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDDEQS 185
             LLP  ++ITPNLPEA  L+       E  +++ G  +        VL+KGGHLD   +
Sbjct: 127 EDLLPLATIITPNLPEAEVLV-GYDLSDEVSIIKAGYDIQKQYSVRNVLIKGGHLDG-LA 184

Query: 186 PDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D+LF  +EG    +  RI T +THGTGCT +A +AA   +  +  + V  AKS+++SA+
Sbjct: 185 KDYLFLEKEGLITLSNQRINTIHTHGTGCTFAAVVAAELAKGQSILNAVSTAKSFITSAI 244

Query: 245 AQADTLEVGHGIGPVHH 261
             A   E+G G GPV+H
Sbjct: 245 ETAP--ELGLGNGPVNH 259


>UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquificales
           RepID=C0QRY4_PERMH
          Length = 262

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 101/257 (39%), Positives = 151/257 (58%), Gaps = 3/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG+D SGGAGIQADLK FSA G YG S +T++  QNT GV+  + +  D +  Q+ 
Sbjct: 5   ALSIAGSDNSGGAGIQADLKVFSAFGVYGMSAVTSVTVQNTLGVKGSHPVPSDILFEQIK 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D+ +D  K GML   + V AV + ++  +++N V DTV+ +K+G  LL  SA+ T 
Sbjct: 65  AVVEDIGVDAFKTGMLQTEENVLAVYQAVKDLRMKNFVADTVIRSKNGKYLLDKSAIETF 124

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
             R++P   +ITPN+ E A +L     R+  +M+   + L  MG  AV++KGGHL     
Sbjct: 125 IKRIVPLADIITPNIDE-AEVLTGIEIRSVDDMIRAAKELYRMGSSAVVVKGGHLPQGDR 183

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
              +F          P + TKNTHGTGCT SAA+ A   +  +    V+ A+S++  A+ 
Sbjct: 184 IVDIFYNGDLYTLEYPYVRTKNTHGTGCTFSAAITACLAKGYDHLKAVRVARSYIQGAI- 242

Query: 246 QADTLEVGHGIGPVHHF 262
             ++L +G G G ++HF
Sbjct: 243 -ENSLSIGKGTGSLNHF 258


>UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WHJ3_BACSK
          Length = 275

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 108/258 (41%), Positives = 161/258 (62%), Gaps = 4/258 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAGTDP+GGAGIQADLKTF  L  YG SVIT+LVAQNT GV++++ +  +F+  Q  
Sbjct: 7   ALTIAGTDPTGGAGIQADLKTFQELEVYGMSVITSLVAQNTTGVRAIHHVPLEFIDQQFQ 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D+     K GM+A  +++E + ++L  ++    V D VM+AK+GDPLL     A L
Sbjct: 67  AVVDDIYPSAIKTGMIALPEMMELLQQQLNSHKNVPYVCDPVMMAKNGDPLLEKHVRAKL 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  L+P  +++TPN+ EA  L+D      +       R +  +G  +V++KGG L  + +
Sbjct: 127 RETLVPLATIVTPNIAEAEDLIDMQIDDIDDMEKAAIRIVKELGAQSVVVKGGSLTGD-A 185

Query: 186 PDWLFTRE-GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D  ++RE G  +  APR  TK+THGTGCT SAA+ A   +     D VQ+AK++ + A+
Sbjct: 186 VDVFYSRETGLFKLDAPRTDTKHTHGTGCTFSAAICAQLAKGIALLDAVQKAKAFTADAI 245

Query: 245 AQADTLEVGHGIGPVHHF 262
               +L++G+G GP +H+
Sbjct: 246 TW--SLQIGNGYGPTNHW 261


>UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Aquifex aeolicus RepID=THID_AQUAE
          Length = 255

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 100/251 (39%), Positives = 144/251 (57%), Gaps = 1/251 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG D SGGAG  AD++TF   G YG +VITAL  QNT+ V  V+ I PD V  +L 
Sbjct: 3   ALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEELK 62

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++F D  I   KIGMLA  +I E V E L+  +   +VLD V  +KSG  LLS   V  L
Sbjct: 63  AIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVEFL 122

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +S  +  V LITPN+PE A +L     ++ +++    + + ++G  +VL+KGGHL    +
Sbjct: 123 KSEFIKIVDLITPNVPE-AEILCGEEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGNYA 181

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L+  +    F AP+I  K   GTGC  S+A+ A   RH +    ++ AK +++ A+ 
Sbjct: 182 IDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAIK 241

Query: 246 QADTLEVGHGI 256
            +  L  G+ I
Sbjct: 242 NSKKLGKGYEI 252


>UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobium/Pelodictyon group
           RepID=Q3ASE2_CHLCH
          Length = 275

 Score =  187 bits (476), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 122/272 (44%), Positives = 166/272 (61%), Gaps = 9/272 (3%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MKR    LTIAG+D SGGAGIQADLKTF+AL  YG SVITA+ AQNT+GV  V+ +E   
Sbjct: 1   MKRYTTVLTIAGSDGSGGAGIQADLKTFAALRCYGVSVITAITAQNTQGVSGVFPVENHC 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN--VVLDTVMLAKSGDPLL 117
           + AQ +++  D+  D  KIGML     +  +A  L+        ++LDTV+ + SG  LL
Sbjct: 61  LQAQFEALQKDITFDAIKIGMLGSASTITTLAALLRALPTPRPPIILDTVLASSSGMALL 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALL-DAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
            PSA+A + S+L P  +LITPN+PE A L   +   +T QE+    + L A G  +VL+K
Sbjct: 121 PPSAIACMVSKLFPLATLITPNIPECALLAGKSAVPQTAQEIEAVAKELQAQGAASVLIK 180

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH    +  D L  +E  Q F+AP I T NTHGTGCTLS+A+AA   +     + V +A
Sbjct: 181 GGHGKSNECHDCLLWQERCQWFSAPMIATHNTHGTGCTLSSAIAAFMAKGYPLDNAVLQA 240

Query: 237 KSWLSSALAQADTLEVG---HGIGPVHHFHAW 265
           K++L+SAL      ++G   +G GP+  FH W
Sbjct: 241 KNYLNSALQAGAAYQLGMSANGHGPL--FHLW 270


>UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharophagus degradans
           2-40 RepID=Q21NU7_SACD2
          Length = 282

 Score =  187 bits (474), Expect = 4e-46,   Method: Compositional matrix adjust.
 Identities = 114/259 (44%), Positives = 161/259 (62%), Gaps = 4/259 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IA +D  G AGIQAD+KT  AL AY  + ITA+ AQN+ GV +++ +  + ++AQ  +
Sbjct: 7   LSIAASDSFGAAGIQADIKTAMALHAYCATAITAVTAQNSLGVAAIHPVPANILSAQFTA 66

Query: 67  V---FSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPSAV 122
               F   R+   KIGML   + + AV   +Q+      VV+DTV+ A SG  LL PSAV
Sbjct: 67  AAQGFLPARLGAIKIGMLGHAEALPAVVSFVQQLAGAIPVVVDTVLNASSGAVLLPPSAV 126

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
              R  LLP  +LITPNL EAA LLDAP A +E +  EQ ++LL +GCGAVL+KGGH + 
Sbjct: 127 RAYRESLLPLATLITPNLHEAALLLDAPLATSEAQQREQAQALLQLGCGAVLLKGGHFEG 186

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
             + D+L T  GE RF++ +I T N+ GTGC+L+AA+A    +       V+ AK+++S+
Sbjct: 187 NSASDYLVTPHGEARFSSSKIQTNNSRGTGCSLAAAIAVGIAQGQPLEQAVEAAKNYISA 246

Query: 243 ALAQADTLEVGHGIGPVHH 261
           AL  A   ++  G GP+ H
Sbjct: 247 ALQGAVGWQLAQGSGPICH 265


>UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0EZ09_9FIRM
          Length = 483

 Score =  185 bits (470), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 107/265 (40%), Positives = 159/265 (60%), Gaps = 15/265 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGIQAD+KT +    Y  + ITAL AQNT G+  +  +  +F   Q++S
Sbjct: 222 LTIAGSDSSGGAGIQADIKTLTVHKVYAMTCITALTAQNTVGITGIMPVPAEFFKKQMES 281

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +F+D++ D  KIGM+A  +  E +AE L++Y I+NVV D VM++ SG  L+  +    L 
Sbjct: 282 IFTDIKPDAVKIGMIASKEQAEIIAEYLEKYSIKNVVADPVMISTSGTVLVEETTRKILY 341

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA--MGCGAVLMKGGHLDDEQ 184
            +L P+VSL+TPN+PE   L  +    T+++  E+   ++A    C AVL KGGH  +E 
Sbjct: 342 EKLYPKVSLLTPNIPETEFL--SGIKITDKKTREEAAKVIADRWNC-AVLSKGGH-SEEN 397

Query: 185 SPDWLF-------TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           + D L+        +E    F   RI   NTHGTGCTLS+A+AA   +     ++V++AK
Sbjct: 398 ADDLLYESFLQEEKKEKAVWFPEERIDNPNTHGTGCTLSSAVAANLAKGFPVEESVKKAK 457

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++S A+     L +G G GP++H 
Sbjct: 458 VYISGAIRA--MLNLGQGNGPLNHM 480


>UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=1
           Tax=Picrophilus torridus RepID=Q6KZH7_PICTO
          Length = 256

 Score =  184 bits (467), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 95/257 (36%), Positives = 151/257 (58%), Gaps = 6/257 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +T+A TD  GGAG+ ADLKT +AL  +G +VI +L AQN+  V+S+Y +   F+  Q   
Sbjct: 1   MTVASTDSGGGAGVMADLKTMTALKVFGTAVIVSLTAQNSVSVRSIYELPEQFIRDQFYE 60

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + SD+  D  K GML   +I+  V + ++ Y ++N+V+D VM++K+G  LL   A+  L 
Sbjct: 61  ILSDIGTDAAKTGMLFSENIINTVYDEMKSYNVKNIVIDPVMVSKTGARLLKEDAIKALV 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           ++L+   +L+TPN+PE A ++         +M      +  M   +VL+KGGH++   S 
Sbjct: 121 NKLMKIATLVTPNIPE-AEVITGMRISDLNDMKNAALKIYNMTGASVLIKGGHMESSVSE 179

Query: 187 DWLFTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L+   GE  F +  RI TKNTHGTG TLS+A+A+         D++  AK ++  A+ 
Sbjct: 180 DVLY--NGEFSFYSDKRINTKNTHGTGDTLSSAIASYLAMGKTLEDSISMAKDYIEGAI- 236

Query: 246 QADTLEVGHGIGPVHHF 262
             ++  +G G GP++HF
Sbjct: 237 -INSFPMGRGYGPLNHF 252


>UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S3_LACBS
          Length = 511

 Score =  184 bits (466), Expect = 3e-45,   Method: Compositional matrix adjust.
 Identities = 111/282 (39%), Positives = 157/282 (55%), Gaps = 24/282 (8%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           + LTIAG+D SGGAGIQADLKTF+A G YG SVITAL AQNT+GV  V+   P+FVA Q+
Sbjct: 8   SVLTIAGSDSSGGAGIQADLKTFAAHGCYGASVITALTAQNTQGVHGVHPCPPEFVAQQI 67

Query: 65  DSVFSDVRIDTTKIGMLAETD----IVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            SV  D+ I+  K GML + +    +V+++    +   +  ++ D V ++ SG  LL P 
Sbjct: 68  HSVLEDLEINAIKTGMLYDVENTKQVVKSLKAHYKNKALPPLICDPVCVSTSGHTLLHPE 127

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTE----QEMLEQGRSLLAMGCGAVLMK 176
           AV  L   L P  +LITPN  EA  LL + +   +    ++ML     LL+ GC AVL+K
Sbjct: 128 AVEILIDELFPLATLITPNKAEAELLLSSRNPFVDITSLEDMLSATEQLLSFGCAAVLLK 187

Query: 177 GGHLDD-------------EQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAAL 222
           GGH+               E   D L+   G++  F  PRI + +THGTGCTLS+A+A  
Sbjct: 188 GGHITSTMTDTGINVADHPELVVDVLYQSNGKKSLFVMPRIESTSTHGTGCTLSSAIACE 247

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
                +  +  + A  +    +  A  +  GH  GP++H H+
Sbjct: 248 LACGLSLEEATKNAAIFTHMGIEAAHPMGKGH--GPLNHLHS 287


>UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WH83_BACSK
          Length = 272

 Score =  184 bits (466), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 104/255 (40%), Positives = 152/255 (59%), Gaps = 2/255 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L++AG+D SGGAGIQAD+KT   LG Y  + ITA+ AQNT GVQS   ++   V  Q+++
Sbjct: 7   LSVAGSDSSGGAGIQADIKTCQELGVYAATAITAITAQNTTGVQSWQGLDASLVRDQIEA 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD+ +   K GML   DIV  VAE    Y++ N+V+D VM + SG  LLS      L 
Sbjct: 67  VLSDIGVHVIKTGMLVNADIVTTVAELANTYRVANIVVDPVMASTSGTALLSAEGQQVLV 126

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            +LLP  ++ TPNLPE A LL+ P  +T  EM      L  MG   V++KGGHL   ++ 
Sbjct: 127 QKLLPLATVFTPNLPETAMLLNKPECKTVAEMKAAAVQLHKMGPKLVILKGGHLRQGEAI 186

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D  +  +      A R+  K+THGTGCT ++A+AA   +     +  ++AK+++++A+++
Sbjct: 187 DLCYDGQAFFELKAKRLDRKHTHGTGCTFASAIAAELAKGAKPIEAAKKAKAYVTAAISE 246

Query: 247 ADTLEVGHGIGPVHH 261
              + +G GIGP  H
Sbjct: 247 G--IPLGAGIGPTDH 259


>UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobacillales
           RepID=C7TG65_LACRL
          Length = 283

 Score =  183 bits (465), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 100/243 (41%), Positives = 148/243 (60%), Gaps = 4/243 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLKTF A   +G S++ AL AQNT GVQ+   I  DF+ AQ  S+ +D  I   K G
Sbjct: 23  MQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPGDFIDAQFQSLAADFAIKACKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA+++ V AV   L++     +++D VM+AK G  LL+P AVAT++  LLP   ++TPN
Sbjct: 83  MLADSEHVNAVVRNLKQVNFGPLIVDPVMVAKGGATLLAPEAVATIKQELLPLADVVTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           LPEA  ++  P  R E +M+   +++  +G   V++KGGH  D Q+ D++   +G   + 
Sbjct: 143 LPEAEIIVGHPIKR-EADMIAAAQTIQELGVKNVIIKGGHRQDAQASDFILLADGSSFWV 201

Query: 200 -APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            +PRI T NTHGTG T SA +AA   +  +    +  AK++L  A++Q   + VGHG GP
Sbjct: 202 RSPRIATGNTHGTGDTFSACIAAELAKGESLKKAIITAKAFLEGAISQG--IFVGHGHGP 259

Query: 259 VHH 261
            +H
Sbjct: 260 TNH 262


>UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobacterium
           RepID=D1NSS6_9BIFI
          Length = 521

 Score =  183 bits (464), Expect = 7e-45,   Method: Compositional matrix adjust.
 Identities = 113/267 (42%), Positives = 156/267 (58%), Gaps = 12/267 (4%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IA TD SGGAG+  D+KT  A G +   VI A+ AQNT+GV  +  + P  +  Q+D
Sbjct: 259 ALSIASTDSSGGAGVPVDIKTMMANGVFAECVICAITAQNTKGVTHLEELSPQAIVKQID 318

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V+ D+     KIGM+   + + AVA+ LQ  +  N+V+D VM+A SG  L++  A+ATL
Sbjct: 319 AVYDDIAPAAVKIGMVPSIEGINAVADGLQANKATNIVVDPVMVATSGAKLINDDAIATL 378

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHART---EQEMLEQGRSLLA--MGCGAVLMKGGH- 179
            SRL P  +LITPNLPE   LL+   +     +++ +EQ    +A   GC +VL+KGGH 
Sbjct: 379 TSRLFPMATLITPNLPETRVLLETIGSSIDPQDEDGMEQAGLAIAQHFGC-SVLVKGGHG 437

Query: 180 LDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L D    D L   +G  Q F   RI   NTHGTGCTLS+A+AA   +     D +  AK 
Sbjct: 438 LADAN--DVLVNADGTTQWFRGERINNPNTHGTGCTLSSAIAANLAKGQTLVDAIANAKR 495

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           +++ AL Q   LE+G G GP  H   W
Sbjct: 496 YITGALRQ--MLELGTGSGPFDHAWMW 520


>UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7MH55_BRAFD
          Length = 599

 Score =  182 bits (463), Expect = 8e-45,   Method: Compositional matrix adjust.
 Identities = 104/254 (40%), Positives = 159/254 (62%), Gaps = 2/254 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           ++IAGTDP+GGAG  ADLK+ +A G YG +V+TA+VAQNTRGV+ ++    + +AAQL +
Sbjct: 2   VSIAGTDPTGGAGTAADLKSITAAGGYGMAVVTAVVAQNTRGVRDIHVPPAEVLAAQLTA 61

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  DV ++  K GML   ++++ VA  +  +  + +V+D VM+A SGD LL P A   + 
Sbjct: 62  VSDDVELEAVKTGMLGTVEVIDTVAAWVAAHPPRVLVVDPVMVASSGDRLLEPEAEQAM- 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD-EQS 185
            R   + +++TPN+ E A L  +P A TE+E L Q  +  A    +V++K GHL+D E +
Sbjct: 121 IRFCARATVVTPNIDELAVLTGSPRASTEEEALAQATAWTARTGASVIVKTGHLEDREVT 180

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
             W+     ++R  + R+ T +THGTGC+L+AALA       + A  ++ A +WL  A+A
Sbjct: 181 NTWVAPDGAQRRARSTRVDTTSTHGTGCSLAAALATRLGAGHSPAAALEWATAWLHEAIA 240

Query: 246 QADTLEVGHGIGPV 259
              +L+VG G GPV
Sbjct: 241 HGASLQVGAGHGPV 254


>UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionibacterium acnes
           RepID=D1Y931_PROAC
          Length = 569

 Score =  182 bits (461), Expect = 1e-44,   Method: Compositional matrix adjust.
 Identities = 114/258 (44%), Positives = 152/258 (58%), Gaps = 2/258 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDPSGGAG  AD K+  A G Y  +V+T+LVAQNT GV++++    DF+  QL +
Sbjct: 64  LSIAGTDPSGGAGTAADTKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQLAA 123

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  DVRID  K GML   +IV+AVA  L  ++   VV+D VM+A SGD LL+P A A +R
Sbjct: 124 VSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVVVDPVMVATSGDRLLAPDAEAAMR 183

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
                + ++ITPN+PE A L  +  A T ++ +EQ R   A    AV++K GHL+ ++  
Sbjct: 184 -EFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQRVD 242

Query: 187 DWLFTREGEQRFT-APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           +   T EG      A R+ T NTHGTGC+LS+ALA          D +     WL  A+ 
Sbjct: 243 NMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEAIQ 302

Query: 246 QADTLEVGHGIGPVHHFH 263
               L VG G GPV H H
Sbjct: 303 YGSALNVGKGHGPVDHSH 320


>UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=9
           Tax=cellular organisms RepID=B8H441_CAUCN
          Length = 267

 Score =  181 bits (460), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 103/242 (42%), Positives = 145/242 (59%), Gaps = 3/242 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT +ALG Y  + ITA+  QNT GV  V+ I  D +AAQ  +V  D+  D  K G
Sbjct: 23  IQADIKTITALGGYAATAITAVTVQNTLGVTGVHPIPLDVIAAQARAVLDDIGADAIKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +  +VE VA+ L        V+D VM+AK G PLL+ +A+  ++S ++P+  L+TPN
Sbjct: 83  MLGDAAVVEIVAQALDHAGGVPAVVDPVMVAKGGAPLLAEAAIGAVKSLMIPRAFLLTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
            PEAAAL       T +++   G +LLA+G  AVLMKGGH+  E+  D L T  GE  F 
Sbjct: 143 APEAAALTGLV-VETTEDLRRAGEALLALGARAVLMKGGHVAGERVVDVLMTPAGETTFE 201

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             RI T++THGTGCTL++A AA   +     + V +A +++  A+ +A     GH  GP+
Sbjct: 202 GERIDTRHTHGTGCTLASACAAGLAKGLKLEEAVAQAWNYVHEAMLRAPGFGAGH--GPL 259

Query: 260 HH 261
            H
Sbjct: 260 DH 261


>UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TP80_9BACT
          Length = 271

 Score =  181 bits (459), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 98/242 (40%), Positives = 146/242 (60%), Gaps = 3/242 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+AL  +G S +TA+ AQN+ GVQ+++ I P+ +  Q+ SV SD  I   K G
Sbjct: 22  IQADLKTFAALRVFGTSALTAVTAQNSLGVQAIHDIPPEIIYEQMKSVLSDFSIGAVKTG 81

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +TD +  V   ++ + +  +V+D VM+A+SGD L+   AV+ ++  LLP  +L+TPN
Sbjct: 82  MLGKTDAIGVVCRAVRDFSVHKLVVDPVMIAQSGDSLIQDDAVSAIKEELLPLATLVTPN 141

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L     +  E  M+    ++  MG  AVL+KGGHL+ E+  D L++     +F 
Sbjct: 142 VPEAERLSGLEVSDVEG-MIAAASAIAGMGPQAVLVKGGHLEGEKVVDVLWSSGKPIKFE 200

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +PRI T+N HGTGCTLSAA+A+           V+  +++L  AL +    + G G GP 
Sbjct: 201 SPRIDTENNHGTGCTLSAAIASELAAGCELDLAVERGRAYLMMALERG--FKPGKGYGPT 258

Query: 260 HH 261
            H
Sbjct: 259 GH 260


>UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicutes
           RepID=D1BR35_VEIPT
          Length = 277

 Score =  180 bits (457), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 106/265 (40%), Positives = 158/265 (59%), Gaps = 10/265 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   ALTIAGTDPSGGAGI ADLK+F +   YG +V+T++VAQNT GV  V  +  + +
Sbjct: 1   MKLHTALTIAGTDPSGGAGIMADLKSFQSRNVYGMAVVTSVVAQNTTGVHHVEHLSLESI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLAKSGDPLLS 118
             QL  V+SD+     K GM+A  ++++ +      Y  +N+  V+D VM+A SGD L+S
Sbjct: 61  EKQLHDVYSDITPQAVKTGMIALPEMMDLI----YPYVSKNIPYVMDPVMIATSGDRLVS 116

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             AV  L+S+L+P  ++ITPN  EA  L D              R L  +G   V++KGG
Sbjct: 117 DEAVDFLKSKLIPVATVITPNRSEAEVLADMSITCESDITTAANRILRELGPQVVIIKGG 176

Query: 179 HLDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H+ D+ + D+ FT++G+   +T+P+  T +THGTGCT SA + A   +  +  D +  AK
Sbjct: 177 HIGDDAT-DYAFTKDGDMHTWTSPKYDTVHTHGTGCTFSAVITAELAKGRDVMDAIGIAK 235

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
           ++++ A+     L  G+G GPV+H 
Sbjct: 236 NYIALAIKHNPAL--GNGCGPVNHM 258


>UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria (class)
           RepID=B8DSX8_BIFA0
          Length = 516

 Score =  180 bits (457), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 110/260 (42%), Positives = 148/260 (56%), Gaps = 7/260 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIA TD SGGAGI ADLKT  A   +G  V+  + AQNT GVQ++  ++P  V AQ+DS
Sbjct: 260 LTIATTDSSGGAGIPADLKTMLANDVFGECVVAGITAQNTTGVQAIAAVDPSIVGAQIDS 319

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF D+R    KIG++   + V+ VA +L+ +Q  N+V+D VM+A SG  L +   +A   
Sbjct: 320 VFDDIRPTAVKIGVIVGVESVKTVARKLRDHQATNIVVDPVMVATSGSSLAADDTIAEEI 379

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKGGHLDDEQS 185
           S L P  ++ITPN+PEA  L   P     Q  +E     LA   G  VL+KGGH   +  
Sbjct: 380 SSLFPIATVITPNIPEAQVLAQMPIGN--QADMETAAVQLAKDYGTCVLVKGGHGVKDAD 437

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
               F       F   RI   NTHGTGCTLS+A+A+   +  +  D V++AK++LS AL 
Sbjct: 438 DVLAFPTGAVTWFEGERIANDNTHGTGCTLSSAIASYLAQGEDLEDAVRDAKAYLSGALR 497

Query: 246 QADTLEVGHGIGPVHHFHAW 265
               L +G G GP+   HAW
Sbjct: 498 A--NLNLGKGHGPMD--HAW 513


>UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agaricales
           RepID=A8NYV6_COPC7
          Length = 556

 Score =  180 bits (456), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 120/310 (38%), Positives = 156/310 (50%), Gaps = 53/310 (17%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DPSGGAGIQADLKTF+A G YG SVIT+L AQNT GVQ V+ + PDFV  QL 
Sbjct: 9   ALTIAGSDPSGGAGIQADLKTFAAHGCYGASVITSLTAQNTTGVQGVHAVPPDFVVQQLR 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ----IQNVVLDTVMLAKSGDPLLSPSA 121
            VF D+ I   K GML +  I   VA+ L+  Q    +  VV D V ++ SG  LL P A
Sbjct: 69  MVFDDIDIKAIKTGMLYDAVIAAEVAKVLKERQAAGKLAPVVCDPVCVSTSGHTLLKPDA 128

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQE----MLEQGRSLLAMGCGAVLMKG 177
           +  L S++ P  +LITPN PE   LL  P++  + E    M      L      AVL+KG
Sbjct: 129 LDVLVSQVFPLTTLITPNKPETELLLKTPNSEVKIESLADMYTAAVELSKKTSTAVLVKG 188

Query: 178 GH------------------------LDDEQSPDWLFTREGEQR---------------- 197
           GH                        L DE     L  R+ ++                 
Sbjct: 189 GHVVSSLKNLEEITQKHSNVEVVKQNLYDENMEILLVGRDPKELNPEIVVDLLYQPDTQS 248

Query: 198 ---FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
              +  PRI + +THGTGCTLSAA+A+   +  +  D V +   +    +A A    +G 
Sbjct: 249 AVVYARPRIESTSTHGTGCTLSAAIASGLAQGLSLKDAVAQGALYTHFGIATAQ--PIGK 306

Query: 255 GIGPVHHFHA 264
           G GP++H H 
Sbjct: 307 GYGPLNHLHC 316


>UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Bacteria RepID=B7GEW3_ANOFW
          Length = 293

 Score =  180 bits (456), Expect = 5e-44,   Method: Compositional matrix adjust.
 Identities = 112/261 (42%), Positives = 158/261 (60%), Gaps = 5/261 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D  GGAGIQADLKTF  L  +G S ITA+ AQNT GVQ VY +  + +  Q+
Sbjct: 35  KALTIAGSDSGGGAGIQADLKTFHQLHVFGMSAITAVTAQNTLGVQGVYPLPIEAIEKQI 94

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           DS+  D+  +  K GML   +I+E VA ++++Y    VV+D VM+AK G PLL   AV  
Sbjct: 95  DSIAIDLPPNAVKTGMLFSEEIIELVARKIKQYGWVRVVVDPVMIAKGGAPLLKQEAVKA 154

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L+  +LP   ++TPN+PEA  L +     T ++  E  + L  MG   V+MKGGH + E+
Sbjct: 155 LQRHMLPLARVLTPNIPEAEVLTNM-RIETFEQRKEAAKKLHDMGVQYVVMKGGHGEGEE 213

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             D L+  E    + + R+ TK+THGTGCT +AA+ A   +     + V  AK ++ +A+
Sbjct: 214 LVDLLYDGEQFYEWKSRRVHTKHTHGTGCTFAAAITAELAKGKTVYEAVNIAKQFIQAAI 273

Query: 245 AQADTLEVGHGIGPVHH--FH 263
            Q  TL++G G GP +H  FH
Sbjct: 274 EQ--TLQIGGGHGPTNHWAFH 292


>UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia denitrificans DSM
           20603 RepID=C7R3Y2_JONDD
          Length = 518

 Score =  179 bits (454), Expect = 9e-44,   Method: Compositional matrix adjust.
 Identities = 116/268 (43%), Positives = 155/268 (57%), Gaps = 10/268 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  LTIAGTDP+GGAG+QAD+KT +A G Y  SV+TA+VAQNT GV+    +    VA Q
Sbjct: 8   IRVLTIAGTDPTGGAGVQADIKTITACGGYALSVVTAVVAQNTVGVRCFESVSSSLVADQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V SD      K+GML +  +   V E   R+    +V+D VM+A SGD L++  A  
Sbjct: 68  LAAVASDTAPAAVKVGMLGDPAVSREVCE-FARHLTVPLVVDPVMVATSGDELVTGVARE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKGGHLDD 182
            L   LLP  +LITPN+PE A L    HA +++E+  Q R L+A   G AVL KGGH   
Sbjct: 127 ALW-ELLPLATLITPNIPELAVLSGMAHAVSDEELEHQAR-LVAHKFGVAVLAKGGHRVG 184

Query: 183 EQSPDWLFTREGEQ------RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           + + D L    G           A R+ T +THGTGC+LS+A+A L  R  +  + V+ A
Sbjct: 185 DTASDVLIGAPGPGGQCEAVWVHAQRVNTTSTHGTGCSLSSAIATLLGRGYDLPEAVRRA 244

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHA 264
           K WL+ A+   D + VG G GP+ H  A
Sbjct: 245 KVWLTQAIRAGDRMAVGTGHGPLDHMWA 272


>UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rhodopirellula
           baltica RepID=Q7UNH4_RHOBA
          Length = 275

 Score =  179 bits (453), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 107/254 (42%), Positives = 151/254 (59%), Gaps = 6/254 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DPSGGAG+QADLKTF + G YGCSV+T L AQNT GVQ +  +  +FV AQ  
Sbjct: 21  ALTIAGSDPSGGAGMQADLKTFHSFGVYGCSVMTLLTAQNTMGVQGIQMVPAEFVRAQWT 80

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SV SD+ +   K G L   +++E VA+ L       +V+D VM++K G P++  +A+  L
Sbjct: 81  SVSSDLPLAAIKTGALGNAELIETVADCLHSLACP-LVVDPVMISKHGHPIIDENAIDVL 139

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            +R+ P   L+TPN  EA  L+     R E ++      LLAMG  AVL+K      E+S
Sbjct: 140 INRVFPLADLVTPNAFEAERLV-GQSIRNEDDLASVADKLLAMGPRAVLIKA--CVGERS 196

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L   +G Q   +PRI +  THG+GC LSAA+ A   +  +  + V+ A++++  A+ 
Sbjct: 197 VDCLADADGAQLLRSPRIESNRTHGSGCVLSAAITAGLAKGQDLIEAVRTARNFVHDAIR 256

Query: 246 QADTLEVGHGIGPV 259
            A  L  G GI P+
Sbjct: 257 NAPKL--GQGISPL 268


>UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Erythrobacter RepID=Q2N848_ERYLH
          Length = 269

 Score =  178 bits (452), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 114/258 (44%), Positives = 148/258 (57%), Gaps = 7/258 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+D SGGAGIQAD+KT + LG Y  + ITA+ AQN+ GVQ +  ++  FV  Q+ S
Sbjct: 9   LAIAGSDSSGGAGIQADIKTITMLGGYAMTAITAVTAQNSVGVQGITPLDGAFVGQQIAS 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATL 125
              D+ +D  KIGML   DI+ AVA  L+    Q  +VLD VM+A SG PL+   AVAT+
Sbjct: 69  AIDDIGVDAIKIGMLQNEDIILAVANALEEIDPQVPIVLDPVMVATSGAPLVVQDAVATM 128

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDDEQ 184
           R RL  +  L+TPNLPE   LL     RT + + E    L    GC  VL KGGH  DE+
Sbjct: 129 RERLFTKARLLTPNLPE-LELLAGKQLRTTELVREAAEDLARHYGCD-VLAKGGHTADER 186

Query: 185 SPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
             D L    G   +F   RI T++THGTGCTLS+A+A L          V+ A+ ++  A
Sbjct: 187 IIDVLVPVGGRMAQFDDARIDTRHTHGTGCTLSSAIATLLGHGQPMEHAVRLARRFVREA 246

Query: 244 LAQADTLEVGHGIGPVHH 261
           +  A     G G GP+ H
Sbjct: 247 IENAPGF--GDGAGPLGH 262


>UniRef50_C2CTG3 Multifunctional thiamine-phosphate
           pyrophosphorylase/synthase/phosphomethylpyrimidine
           kinase n=1 Tax=Gardnerella vaginalis ATCC 14019
           RepID=C2CTG3_GARVA
          Length = 565

 Score =  177 bits (449), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 115/266 (43%), Positives = 153/266 (57%), Gaps = 12/266 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDP+GGAGIQADLK+ +A   +   V T LVAQNT GV+ VY    DF+ AQL++
Sbjct: 40  LSIAGTDPTGGAGIQADLKSITASHGFAMCVTTNLVAQNTCGVREVYTPPTDFLQAQLEA 99

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF DV ID  KIGML +   +  V + L+ + +  VVLD VM+A SGD LL  SA   +R
Sbjct: 100 VFDDVTIDAVKIGMLGDKSYISLVQDWLKNHPVPVVVLDPVMVATSGDRLLEKSAEDAMR 159

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
               P   +ITPN+PE A L D   A   +E   Q     A     V++KGGHL  E + 
Sbjct: 160 -EFAPLADVITPNIPELAVLCDKQPASNFEEAYAQASEWCAKNNTIVIVKGGHLTSEDAG 218

Query: 187 DWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALA-----ALR-----PRHTNWADTVQE 235
           + +   +G +     PR+ T  THGTGC+LS++LA     ALR       ++  AD +  
Sbjct: 219 NTVVFPDGHRVHVPCPRVDTTTTHGTGCSLSSSLATRIGLALREGKKLSDYSTVADALAW 278

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHH 261
           +  WL+ A+A    L VG G GPV+H
Sbjct: 279 SSRWLNEAIACGKDLHVGKGHGPVNH 304


>UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria RepID=C8X581_DESRD
          Length = 269

 Score =  177 bits (448), Expect = 4e-43,   Method: Compositional matrix adjust.
 Identities = 123/269 (45%), Positives = 166/269 (61%), Gaps = 12/269 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+I  LTIAG+D  GGAGIQ DLKT + LG +G SV+TAL AQNT GVQ V+ +   F+
Sbjct: 1   MKKI--LTIAGSDSGGGAGIQTDLKTIALLGGHGTSVLTALTAQNTLGVQGVHPVPEAFI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++SV +D+  DT KIGMLA   IV  VAE L+      +VLD VM+A SGDPLL+  
Sbjct: 59  RQQMESVLTDIGTDTLKIGMLATAGIVRTVAEGLRALTAAPLVLDPVMVATSGDPLLAED 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGH 179
           A  +L+  L P  +++TPNL EA  L   P   T++  +EQ  + + A G   VL+KGGH
Sbjct: 119 ARQSLQDNLFPLAAVVTPNLGEAELLCGFP--VTDRAGMEQAAAAIHARGPAYVLLKGGH 176

Query: 180 LDDEQSPDWLFTREGEQRFTAP--RIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           L D+ + D LF  +G Q    P  R+ T +THGTGCT SAA+A    +  +    V +AK
Sbjct: 177 LVDDAA-DLLF--DGHQGIWLPGHRVDTVHTHGTGCTYSAAIATFLAQSGDMVQAVTQAK 233

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            +++ A+A A  L  GHG GP + + A +
Sbjct: 234 RFITRAIAAAGPL--GHGRGPTNPYAAVF 260


>UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=uncultured archaeon
           RepID=D1JA17_9ARCH
          Length = 438

 Score =  177 bits (448), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 104/254 (40%), Positives = 151/254 (59%), Gaps = 8/254 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR+  +TI G+D SGGAGIQAD+KTFSAL  +G SV+TA+ AQN+ GVQ++  +    V
Sbjct: 1   MKRV--MTIGGSDCSGGAGIQADIKTFSALAVHGTSVLTAITAQNSDGVQAIQEVPVKIV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV SD+ +D  K GML   +I+   A +L+RY +   VLD VM A +G  LL  +
Sbjct: 59  EQQLESVMSDIAVDYAKTGMLYSAEIIAVAATQLKRYGVP-FVLDPVMKAGAGGILLDDN 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL   L+P  +++TPN+PE A+++     R  ++       +  MG  AV++KGGHL
Sbjct: 118 ALNTLIELLIPICAVVTPNVPE-ASIISGLEIRNIEDAKLAALKINDMGASAVIIKGGHL 176

Query: 181 DDE----QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           + E    ++ D ++  E E+  T+     K  HG GCT SAALAA   + TN  D    A
Sbjct: 177 EHEIAAGKATDLIYDGEFERISTSMIKQGKIVHGAGCTFSAALAAELAKGTNLHDAATSA 236

Query: 237 KSWLSSALAQADTL 250
           K ++  A+   + L
Sbjct: 237 KKFVYDAILCGEKL 250


>UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=Q2S369_SALRD
          Length = 290

 Score =  176 bits (447), Expect = 6e-43,   Method: Compositional matrix adjust.
 Identities = 111/258 (43%), Positives = 157/258 (60%), Gaps = 4/258 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLK   A G +G S + A+ AQNT  V   + + P  VA Q+D
Sbjct: 7   ALTIAGSDSGGGAGIQADLKAMEANGVFGASALAAVTAQNTEEVSRAHDLPPSLVATQID 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D+ +   K GML+   I+E VA+R+  + ++  V+D VM++K+G  LL   A+ TL
Sbjct: 67  AVVGDMDVKAAKTGMLSAPPIIETVADRVATHDLRPFVVDPVMISKTGFKLLQDEAIDTL 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD-EQ 184
            + LLP  +L+TPN+ EA  L D     T  ++   G +LL  G  AVL+KGGHL   + 
Sbjct: 127 VNDLLPLATLVTPNVHEAEHLTDV-EIDTPDDLRAAGAALLEYGPDAVLVKGGHLSGADD 185

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D L   E  +RF APRI T++THGTGCT ++A+AA   +  +    V  AK +++ A+
Sbjct: 186 AVDVLVDGETGRRFQAPRIDTEHTHGTGCTYASAIAAHLAKGHDLGAAVDRAKRYVTGAI 245

Query: 245 AQADTLEVGHGIGPVHHF 262
             A  L +GHG GP +HF
Sbjct: 246 RHA--LPLGHGRGPTNHF 261


>UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=Q1ASC3_RUBXD
          Length = 264

 Score =  176 bits (445), Expect = 9e-43,   Method: Compositional matrix adjust.
 Identities = 106/264 (40%), Positives = 146/264 (55%), Gaps = 7/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR+  ++IA +D   GAGIQADLK F   G YG + + A+ AQNT GV+S++   P   
Sbjct: 1   MKRV--MSIATSDSGAGAGIQADLKAFLRCGVYGTTALVAITAQNTVGVRSIFPFPPRVA 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++V  D+  D  K GML   +I+ AVA  ++R  I N+V+D VM+A+SG  LL   
Sbjct: 59  VDQIEAVVEDIGADAAKTGMLFNAEIISAVAGAVRRLGIPNLVVDPVMVAESGAKLLKDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AVAT +  L P  ++ITPN+ EA ALL A     E  + E    L + G GAV++ GGH 
Sbjct: 119 AVATYKQELFPLAAVITPNINEAFALLGAE--VDEGRVREAAAELRSFGSGAVIITGGH- 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D L+  E       P   ++NTHG GCT SAALA+   R     +  + A+   
Sbjct: 176 -TASGADLLYDGERFLEIEGPTYGSENTHGAGCTHSAALASFLARGLGLEEAARRAREVA 234

Query: 241 SSALAQADTLEVGHGIGPVHHFHA 264
           S A+ +    E+G G GPVH   A
Sbjct: 235 SEAV-RYGLGEIGSGAGPVHALGA 257


>UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobiaceae
           RepID=B3QNM3_CHLP8
          Length = 276

 Score =  174 bits (440), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 114/258 (44%), Positives = 152/258 (58%), Gaps = 3/258 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGIQADLKT +A   YG SVITA+ AQ+T GV  V+ I   F+A Q ++
Sbjct: 11  LTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQFET 70

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + SD+RID  KIGML      E +A  +       +VLDTV+ + SG  L S +  A ++
Sbjct: 71  IVSDIRIDAIKIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAAMK 130

Query: 127 SRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
            RL P VSLITPNLPEA  L   +AP +  ++E+ +    L   G  +VL+KGGH + + 
Sbjct: 131 -RLFPLVSLITPNLPEATMLTGRNAPPSGGKEEIEQIALELQMQGAPSVLVKGGHWEGKV 189

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             D L   E    F+ P+I T NTHGTGCTLS+A+AA        ++ V     +   AL
Sbjct: 190 CHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVARGIDYTRKAL 249

Query: 245 AQADTLEVGHGIGPVHHF 262
                  +GHG GP++HF
Sbjct: 250 QAGAGWRLGHGHGPLYHF 267


>UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Actinobacteridae RepID=D2NTJ0_9MICC
          Length = 590

 Score =  172 bits (435), Expect = 1e-41,   Method: Compositional matrix adjust.
 Identities = 120/277 (43%), Positives = 159/277 (57%), Gaps = 23/277 (8%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAGTDPSGGAGIQADLK+ +A G YG  V T+LVAQNT GV+ V+    +F+ AQL +
Sbjct: 50  LSIAGTDPSGGAGIQADLKSIAASGGYGMCVTTSLVAQNTCGVREVFTPPLEFLTAQLAA 109

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           VF DV +D  KIGML + D +  V   L  + +  VVLD VM+A SGD LL   A   LR
Sbjct: 110 VFDDVTVDAVKIGMLGDADTIRTVRTWLSEHPVPVVVLDPVMIASSGDRLLQAEAEQALR 169

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L+P V++ITPN+PE A L +   A+T  E  EQ  +L A     V++KGGHL  + + 
Sbjct: 170 D-LVPLVNVITPNIPELAVLCEKEPAQTFDEAHEQAANLAAATGTTVIVKGGHLCGQDAG 228

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALA----------ALRPRHT------NW 229
           +     +G       PR+ ++NTHGTGC+LS++LA          A    HT        
Sbjct: 229 NTAVFPDGTCAHVRTPRLDSRNTHGTGCSLSSSLATRLGVELLQHAEVAEHTAEQSVLTS 288

Query: 230 ADT---VQEAKSWLSSALAQADTLEV--GHGIGPVHH 261
            DT   +Q +  WL  ++A    L+V  G G GPV H
Sbjct: 289 EDTHRALQWSTRWLHESIAAGAGLQVGSGEGHGPVDH 325


>UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Alphaproteobacteria RepID=Q2W2C4_MAGSA
          Length = 270

 Score =  172 bits (435), Expect = 1e-41,   Method: Compositional matrix adjust.
 Identities = 107/246 (43%), Positives = 147/246 (59%), Gaps = 5/246 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+K  + LG +  + +TAL AQNT GV  ++ + PDFV AQ+ +V SD+  D  K G
Sbjct: 21  IQADIKAVTCLGGFAATAVTALTAQNTLGVSGIHEVPPDFVRAQMAAVLSDIGADCIKTG 80

Query: 80  MLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           MLA   IVE VA  L+       +VLD VM+AK G  LL+ SA   L  RL+P+  L+TP
Sbjct: 81  MLASAAIVETVALALEELAPAVPLVLDPVMVAKGGAALLADSAAGALVKRLVPRARLLTP 140

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE-QR 197
           N+PEA  LL     +    M    R LLA+G  AVL+KGGHL+ +   D L    G  +R
Sbjct: 141 NIPEAEVLLGRA-IKGADGMEGAARDLLALGPKAVLLKGGHLEGDHLVDVLAEAGGGLRR 199

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           FT  RI +++THGTGCTL++A+AA   +     + V+ A+++L  A+  A  L  GH  G
Sbjct: 200 FTGRRIASRSTHGTGCTLASAIAAGLAQGLGLVEAVERARAYLVRAIETAPGLGSGH--G 257

Query: 258 PVHHFH 263
           P++H H
Sbjct: 258 PLNHGH 263


>UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=11
           Tax=Helicobacter pylori RepID=THID_HELPJ
          Length = 269

 Score =  171 bits (434), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 97/244 (39%), Positives = 138/244 (56%), Gaps = 6/244 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLK F   G +G SVIT + AQNT+GV  VY +  + V AQ+ ++  D  I   K+G
Sbjct: 21  IQADLKAFQTFGVFGTSVITCITAQNTQGVHGVYPLSVESVKAQILAIRDDFSIKAFKMG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
            L    I+E VA  L+       VLD VM+AK+G  LL   A+ +L+ RLLP+ +L+TPN
Sbjct: 81  ALCNAQIIECVANALETCDFGLCVLDPVMVAKNGALLLEEEAILSLKKRLLPKTNLLTPN 140

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG---HLDDEQSPDWLFTREGEQ 196
           LPE  A L    AR ++   +    L  +G    ++KGG   H   E S DW+F  + E 
Sbjct: 141 LPEVYA-LTGVQARDDKSASKAMGVLRDLGVKNAVIKGGHTEHFQGEFSNDWVFLEDAEF 199

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
             +A R  TKNTHGTGCTLS+ +  L  +  +  + + +AK  L+  +   + L +GHG 
Sbjct: 200 ILSAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAITKAKELLTIII--QNPLNIGHGH 257

Query: 257 GPVH 260
           GP++
Sbjct: 258 GPLN 261


>UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0W4_9BACT
          Length = 274

 Score =  171 bits (434), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 110/264 (41%), Positives = 148/264 (56%), Gaps = 9/264 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D S GAG+QADLKT SALG YG + IT +VA+    V ++  IEP  VA Q+  
Sbjct: 6   LTIAGSDNSAGAGVQADLKTMSALGVYGVTAITCVVAEVPGKVSAIQAIEPRIVAEQIRL 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRY-----QIQNVVLDTVMLAKSGDPLLSPSA 121
           +F    I   K GML   +I+E V + L+       Q   +V+D VM+A SGDPLL   A
Sbjct: 66  LFEAFPIGALKTGMLYSCEIIETVCDTLRGCREPMPQPPPIVVDPVMVATSGDPLLQRDA 125

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +A  R RL P  +LITPNL E   LLD     +  EM   G+ L+A    A L+KGGHL 
Sbjct: 126 IALYRERLFPMATLITPNLDEVRTLLDR-EVTSVAEMRTAGQELVATYGRAFLIKGGHLR 184

Query: 182 DEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              + D L   +G  Q F+AP +   +THGTGCT +AA+ A   +  + ++   EAK +L
Sbjct: 185 LNPAIDLLCAPDGGVQEFSAPFVPGVSTHGTGCTYAAAITAGLAKGLSLSEAASEAKQYL 244

Query: 241 SSALAQAD--TLEVGHGIGPVHHF 262
           ++ +A       E G     +HHF
Sbjct: 245 ATTVAHFLRWPREDGRTTDALHHF 268


>UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholderiaceae
           RepID=A4SX91_POLSQ
          Length = 293

 Score =  171 bits (433), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 112/272 (41%), Positives = 155/272 (56%), Gaps = 11/272 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D  GGAG+QADLK  +ALG YG SVITA+ AQNT GV  +  ++ D V AQ+
Sbjct: 13  KVLTIAGSDSGGGAGLQADLKVITALGGYGMSVITAITAQNTLGVTRIQDVDLDVVEAQI 72

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+V  D+  D  KIGMLA  +IV  VA+ L+R+ ++ ++LD V+ A SG  L        
Sbjct: 73  DAVLMDIGADIVKIGMLASPEIVRTVAKALRRHGVKRIILDPVLRATSGASLGGDDTAQA 132

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD-- 182
           + + L P  SL+TPNL EA+ LL         +     + LL MG  AVL+KGGHLD   
Sbjct: 133 MIAELFPIASLVTPNLEEASLLL-GREISGPNDFKLAAQELLDMGPQAVLIKGGHLDSTH 191

Query: 183 EQSPDWLFTREGE--------QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQ 234
            Q  D+L  R  E        + F   R+ T NTHGTGCTL++A+A       +   +V 
Sbjct: 192 TQITDFLMWRSVEDELEVILTKEFKHYRVNTINTHGTGCTLASAIATYLADGHDLLHSVA 251

Query: 235 EAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +A +++ + L     L +G G GP+ H H ++
Sbjct: 252 KAIAYVEAGLEAGRFLSIGEGPGPLWHMHDFY 283


>UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=48
           Tax=Lactobacillales RepID=Q040Q3_LACGA
          Length = 278

 Score =  171 bits (432), Expect = 3e-41,   Method: Compositional matrix adjust.
 Identities = 100/266 (37%), Positives = 146/266 (54%), Gaps = 6/266 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           + I ALTIAG D  G AG+ ADL  F A G YG  ++TA VA N++G+ +   +  DF+ 
Sbjct: 10  EHIEALTIAGHDSDGSAGMPADLHAFYARGVYGMGLLTAAVAGNSQGIFAQQLMPLDFIQ 69

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q D +  D +I   K GMLA  DI+  VA+ L+ YQ+QN+VLD V++ K G  LL+  A
Sbjct: 70  KQFDVLNDDFKIKAVKTGMLANKDIINVVAKNLEHYQMQNIVLDPVIITKHGATLLADDA 129

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
                 +L+P  ++ITPN  EA  L      + E E+ +  + L  MG   VL+KG H +
Sbjct: 130 YQAFLKKLVPLATIITPNFFEAQKLT-GLELKNESEIKQGAKMLQKMGAKNVLIKGSHHN 188

Query: 182 DEQS--PDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           D+Q+   D+L   +G ++    P   T   +GTG TLSA +AA   +  +    V+ AK 
Sbjct: 189 DKQTEVKDYLLLEDGSDEWLIKPYFKTDRVNGTGDTLSAVIAAELAKGNDVKTAVKIAKD 248

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
           +   AL+    + VG   GP++H  A
Sbjct: 249 FTYEALSHP--INVGAKYGPINHLAA 272


>UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase n=2
           Tax=Bacteria RepID=Q2LST1_SYNAS
          Length = 293

 Score =  170 bits (430), Expect = 5e-41,   Method: Compositional matrix adjust.
 Identities = 115/259 (44%), Positives = 161/259 (62%), Gaps = 12/259 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKT + LG +G SVITAL AQNT GVQ ++ +   F+  Q D+
Sbjct: 9   LTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPISFIEQQFDA 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V +D+ +D  K GML    +V AVA ++++++I+ +V+D V+ AK G  L+   A+ TL 
Sbjct: 69  VATDIGVDAAKTGMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIEDEAMETLV 128

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           S LLP   ++TPN+PEA  + +   +    +M E  R +   G   V++KGGHL  E + 
Sbjct: 129 SDLLPLAFVVTPNVPEAEVMAEMTISSV-ADMKEAARRIRRFGVPNVIVKGGHLPGE-AL 186

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALA---AL-RPRHTNWADTVQEAKSWLSS 242
           D L+       F A RI TK+THGTGCT SAALA   AL +P H    D+V+EAKS+++ 
Sbjct: 187 DILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLH----DSVREAKSYITE 242

Query: 243 ALAQADTLEVGHGIGPVHH 261
            +  A    +G G GP +H
Sbjct: 243 VIRYA--WRIGGGHGPTNH 259


>UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
           n=2 Tax=Schizosaccharomyces RepID=THI22_SCHPO
          Length = 551

 Score =  170 bits (430), Expect = 5e-41,   Method: Compositional matrix adjust.
 Identities = 99/259 (38%), Positives = 142/259 (54%), Gaps = 17/259 (6%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           +LTIAG+D SGGAGIQADLKT ++LG YG S IT LVA+N  GV SV  + P FV +Q+D
Sbjct: 38  SLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVESQID 97

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
               D+     K GML   +IV+AVA   +++    +V+D VM+A SGD L++   V+ L
Sbjct: 98  CCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIVSVL 157

Query: 126 RSRLLPQVSLITPNLPEAAAL-----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
              LLP   L+TPN+PEA  L     LD  +  +  +M      +  +G   VL+KGGH+
Sbjct: 158 NEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKGGHM 217

Query: 181 ----------DDE--QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
                     DDE  +  D L+       F++  +     HGTGCTLS+A+A+      +
Sbjct: 218 PVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAWEHS 277

Query: 229 WADTVQEAKSWLSSALAQA 247
             + VQ    ++  A+  +
Sbjct: 278 LTEAVQFGIDYVHGAITHS 296


>UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_BACSU
          Length = 271

 Score =  169 bits (428), Expect = 8e-41,   Method: Compositional matrix adjust.
 Identities = 114/272 (41%), Positives = 154/272 (56%), Gaps = 22/272 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQAD+KTF  L  +G S ITA+ AQNT GV  V+ +  + +
Sbjct: 1   MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  D+R D  K GML   D++E VA ++  Y    V++D VM+AK G  LL   
Sbjct: 61  RQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAAL-------LDAPHARTEQEMLEQGRSLLAMGCGAV 173
           +VATL+  L+P+   ITPN+PEA  L       LD      EQ        L+ MG   V
Sbjct: 121 SVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKAAEQ--------LVKMGAQHV 172

Query: 174 LMKGGHL-DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           ++KGGH  +D    D LF      + T P I TK+THGTGCT +AAL A     T   D+
Sbjct: 173 IIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTA----QTAKGDS 228

Query: 233 VQEAKSWLSSALAQA--DTLEVGHGIGPVHHF 262
           + +A    ++ + +A  +TL +G G GP +HF
Sbjct: 229 IHQAFEVAANFVREAVENTLGIGSGHGPTNHF 260


>UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kinase n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q449_9BACT
          Length = 276

 Score =  168 bits (426), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 101/243 (41%), Positives = 143/243 (58%), Gaps = 8/243 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D  GGAGIQAD+KT +ALG Y  + ITAL AQNT G+ +VY I   FVA Q+
Sbjct: 10  KALTIAGSDSIGGAGIQADMKTIAALGGYAATAITALTAQNTLGIHAVYEIPASFVARQI 69

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+V SD   D  K GML   DI+E VA RL+ Y +  VV+D VML+K+G  LL+  A+  
Sbjct: 70  DAVVSDTGADIVKTGMLYSKDIIETVASRLKHYALSPVVVDPVMLSKNGAALLAEDAIPA 129

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL---D 181
           L S+L P   ++TPN+PEAA  +     +   +  +  + +  +G   VL+KGGH     
Sbjct: 130 LISQLFPLAFIVTPNIPEAAH-ISGIKIQNITDAEKAAKYIHKLGPANVLIKGGHALHSS 188

Query: 182 DEQSP----DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           D +S     D L+T +         +  K+ HGTGC  ++A+AA   +    A+ V++AK
Sbjct: 189 DIKSSNTVIDILYTGKSFAYIEGEYLPAKHVHGTGCVYASAIAAYLAKGCGIAEAVRQAK 248

Query: 238 SWL 240
            ++
Sbjct: 249 KFV 251


>UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L3K0_MAGSM
          Length = 260

 Score =  167 bits (424), Expect = 3e-40,   Method: Compositional matrix adjust.
 Identities = 99/255 (38%), Positives = 143/255 (56%), Gaps = 6/255 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+DP  GAG+QADLKT +ALG YG +V+TA+  QN+  V  V+ +E   VAAQ+ +
Sbjct: 6   LTIAGSDPCAGAGLQADLKTITALGGYGATVVTAITVQNSVKVSQVHPVEGSLVAAQMRA 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD+ I   K+GML    +VEAV   L  Y    VV DTV+   +G  LL+   VA   
Sbjct: 66  VLSDLPIKAIKLGMLGNRGVVEAVLSVLDHYPEIPVVADTVLRGSAGGALLADEDVAHFV 125

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP+  LITPNL EA  L          ++      L+ +GCG V++ GGHL   +  
Sbjct: 126 QHLLPRCHLITPNLDEAQRLTGLEGGVGVADLESLAYRLMGLGCGGVVLTGGHLVGNKVV 185

Query: 187 DWLFTREGEQRFTAPRIMTKNT-HGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L  + G +R+   +I +K   HGTGCTL++A+A    +  +  + V+E  +++   + 
Sbjct: 186 DTLVCKGGIKRWIGEKIASKEGFHGTGCTLASAVALGVAKGLDDFEAVEEGIAYVRQTIR 245

Query: 246 QADTLE-----VGHG 255
           ++  L      +GHG
Sbjct: 246 RSIKLGSGQRFLGHG 260


>UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprothermobacter
           proteolyticus DSM 5265 RepID=B5Y6H9_COPPD
          Length = 262

 Score =  167 bits (424), Expect = 3e-40,   Method: Compositional matrix adjust.
 Identities = 99/249 (39%), Positives = 145/249 (58%), Gaps = 6/249 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+ADL TF  L  +G   ITA+ AQN+RGV  V+ I PD V AQ+D+V  D  +   K G
Sbjct: 14  IEADLATFLHLHVFGTVAITAVTAQNSRGVHGVFDIPPDGVRAQIDAVLKDFSVGAVKTG 73

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  + +  VA+ L  Y  + +V+D VM+A+SGD L+   AV  L  +LLP   ++TPN
Sbjct: 74  MLSREETISEVAKALSEYNCKKLVVDPVMVAQSGDSLIFGDAVKALEEKLLPLAFIVTPN 133

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE-QRF 198
           +PE A +L     ++ ++M +  +++  +G  +VL+KGGHL+++Q  D LF  EGE   F
Sbjct: 134 IPE-AQILTGITIKSSEDMKKAAKAISKLGPQSVLVKGGHLEEKQLVD-LFYYEGEFYTF 191

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
           T  +I T + HGTGCTLSAA+ A    +T   + V+ A  +  + L      + G G G 
Sbjct: 192 THEKIDTLDHHGTGCTLSAAITAELAANTETVEAVKRAIDY--TRLGIEHRFKGGKGYGC 249

Query: 259 VHH-FHAWW 266
           V H F   W
Sbjct: 250 VGHIFDIDW 258


>UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter rectus RM3267
           RepID=B9CYF9_WOLRE
          Length = 264

 Score =  167 bits (424), Expect = 3e-40,   Method: Compositional matrix adjust.
 Identities = 98/264 (37%), Positives = 150/264 (56%), Gaps = 7/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK +  L+IAG DPSGGAG+ ADLK F+A G Y    ITAL AQNT+G+  +  +E D +
Sbjct: 1   MKHV--LSIAGVDPSGGAGVIADLKVFAAHGVYAMGAITALTAQNTKGIFDMQLVECDLI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSP 119
           A Q++++F D+R+D  KIG++    I++ VA  L++   +  VVLD VM  K+GD  L  
Sbjct: 59  AKQIEAIFDDIRVDAVKIGVVPSEQIIKTVAATLRKVSNLPPVVLDPVMSCKNGDIWLEG 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           +A   + S L P  ++ITPN  EA  ++     +++ E  +  + LL  G  +V +K G 
Sbjct: 119 AAKDAIVSELFPLSTVITPNKFEAREIVKR-EPKSKDEFKQACKELLKTGAKSVYLKCGD 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +    S D  +       F   RI T +THG+GC+LS+A+A+      +  ++ Q A  +
Sbjct: 178 VGG-VSLDLFYDGAEFTEFEQERIDTSSTHGSGCSLSSAIASNLALGFSLRESAQRANKY 236

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +  A+  A    VG G  P++HFH
Sbjct: 237 VYKAIKAA--FAVGSGCNPINHFH 258


>UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S5F9_OSTLU
          Length = 478

 Score =  166 bits (421), Expect = 5e-40,   Method: Compositional matrix adjust.
 Identities = 115/271 (42%), Positives = 166/271 (61%), Gaps = 9/271 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   L +AG+D  GGAG+QAD+K   A GA+  + ITAL AQNT GV  V+    +F+
Sbjct: 1   MVRGKVLVVAGSDSGGGAGVQADVKAILAHGAFATTAITALTAQNTTGVHGVHAAPLEFI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+++V +D+  D  K GMLA      AVA+ ++R+++ NVV+DTVMLAK G  LL   
Sbjct: 61  EAQIEAVVTDLPPDACKTGMLANAATTRAVADAIERHRLTNVVVDTVMLAKGGASLLEAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQE-MLEQGRSLLAMGCGAVLMKGGH 179
           A+  +R RL P  ++ITPN+PEAAALL+        E M  + + L  +GC  VL+KGGH
Sbjct: 121 ALEVMRDRLAPLATVITPNVPEAAALLNLSEEEFVMETMATRAKELGKLGCQWVLLKGGH 180

Query: 180 LDD--EQSPDWLFTREGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           + D  E S D+L+     +   F++ RI T++THGTGCTL++++AA   +  +    V  
Sbjct: 181 VKDDAEMSVDYLYEANTGRTTTFSSARIDTRHTHGTGCTLASSIAASLAQRYDVPTAVHR 240

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHH--FHA 264
           AK ++S A+  +     GH  GP++H  FHA
Sbjct: 241 AKRYISEAIRTSPGYGAGH--GPLNHLPFHA 269


>UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasmataceae
           RepID=Q3YSR2_EHRCJ
          Length = 269

 Score =  166 bits (420), Expect = 8e-40,   Method: Compositional matrix adjust.
 Identities = 93/257 (36%), Positives = 146/257 (56%), Gaps = 7/257 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D  GGAGIQAD+KT SALG Y  S IT++ AQNT  V +VY +  + +  Q++
Sbjct: 10  VLTIAGSDSCGGAGIQADIKTISALGCYAASCITSVTAQNTSQVYNVYNMPQNIIKQQIE 69

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V SD+ ID  KIGML  ++ + AVA+ L    I   V+D VM++ S   L+  SA+   
Sbjct: 70  AVLSDIDIDAIKIGMLPSSEAIIAVAQSLPHIPI---VVDPVMISTSNFRLMDNSAIFDF 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
              ++ + ++ITPN+ EA  L        + +M++  + + ++G   VL+KGGH++ E  
Sbjct: 127 IKHIIYRATIITPNITEAEVLAQTK-IINQDDMIKASQQIKSLGAKYVLIKGGHINQETI 185

Query: 186 PDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            + L T + +   F   RI     HGTGCTLS+A+A+   +  +  ++V  A  ++   +
Sbjct: 186 NNILLTEDNQILNFPHQRIFDGELHGTGCTLSSAIASFISQKISVQESVNLAIQYILKTI 245

Query: 245 AQADTLEVGHGIGPVHH 261
                 ++G G  PV H
Sbjct: 246 KTVP--QIGKGNNPVFH 260


>UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria RepID=A7HV13_PARL1
          Length = 282

 Score =  166 bits (419), Expect = 9e-40,   Method: Compositional matrix adjust.
 Identities = 99/240 (41%), Positives = 142/240 (59%), Gaps = 8/240 (3%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+K+ SA+G +  + +TA+  QNT GV  ++ +  D V AQ+ +V  D+  D  K G
Sbjct: 23  IQADIKSVSAMGGFAMTAVTAITVQNTLGVHGIHEVPVDVVVAQMKAVMEDIGADAVKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML   +IVEAVA +L        +V+D VM+AK G  LL  SAVA L+  L+P  +LITP
Sbjct: 83  MLHSAEIVEAVAAQLSEENAPGFLVVDPVMIAKGGAALLEGSAVAALKEVLIPLATLITP 142

Query: 139 NLPEAAALLDAPHARTEQEMLEQ---GRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE 195
           N+PEA  L      R+  ++  Q     +LL +GC AVL+KGGHL  +   D L T+E  
Sbjct: 143 NVPEAEVLT----GRSITDLASQKAAADALLGLGCDAVLLKGGHLSGDTLFDVLATQETV 198

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHG 255
             F++PRI T++THGTGC L++A+AAL  +       V+ A+ ++  A+  A     GHG
Sbjct: 199 HTFSSPRIDTRHTHGTGCALASAIAALLAQGVELTAAVEAARDYIHEAIRTAPGFGKGHG 258


>UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovibrionales
           RepID=C6BTQ6_DESAD
          Length = 453

 Score =  165 bits (418), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 108/258 (41%), Positives = 152/258 (58%), Gaps = 8/258 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLK  S  G YG S ITAL AQNT GV  +  + P+FVA Q+++
Sbjct: 8   LTIAGSDSGGGAGIQADLKAISMAGCYGASAITALTAQNTTGVTGIEAVSPEFVALQIET 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD+++   K GML    I+ AV E L+      +V+D V +A SG  LL   AV  ++
Sbjct: 68  VCSDIKVSAAKTGMLFSAPIIRAVGESLKDKDFP-LVIDPVCVATSGAKLLKDDAVEAMK 126

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             + P   L+TPN+PE A L      ++ +++ +    LL MG  AVL+KGGH D   + 
Sbjct: 127 -EIFPLAELLTPNVPE-AELFTGMEIKSREDVFKAIEILLEMGPKAVLVKGGHFDSVAAT 184

Query: 187 DWLFTREGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           DWL  + G+Q       R+ TKN+HGTGCTLSA +A+   +  +    V++A+ +L+ AL
Sbjct: 185 DWLGIK-GQQPIPLMQQRVKTKNSHGTGCTLSATIASGLAKGYDMVTAVRKAQEYLNLAL 243

Query: 245 AQADTLEVGHGIGPVHHF 262
                 ++G G GP +H 
Sbjct: 244 RAG--FDLGEGSGPPNHL 259


>UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B7D2_THEAS
          Length = 271

 Score =  165 bits (418), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 112/257 (43%), Positives = 143/257 (55%), Gaps = 3/257 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R  A+TIAG+D  GGAGIQADLKTF  L  +G S +TA+ AQN+ GV  V  +    V
Sbjct: 1   MYRGVAMTIAGSDSGGGAGIQADLKTFMGLNVFGVSAVTAVTAQNSMGVYHVENLSVRSV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+  + SD  +   KIGML+  +I+EAVAE L  Y    VVLD VM+++SG  L+   
Sbjct: 61  REQIRCLLSDFPVRAVKIGMLSTGEIMEAVAEELSSYP-GPVVLDPVMVSQSGHSLMDSG 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHAR--TEQEMLEQGRSLLAMGCGAVLMKGG 178
           A   +R RLLP  SL+TPNLPEA  LL  P     T+ +ML+    LL  GC  VL+KGG
Sbjct: 120 AERAMRERLLPLASLVTPNLPEAERLLGLPPGSIATKGDMLDAANRLLEAGCRGVLLKGG 179

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           HL  +   D L     E  F   RI   N HGTGCTLS+A+AA      +    V   + 
Sbjct: 180 HLPGDDIFDVLICGAEEVLFEDRRIPGGNDHGTGCTLSSAIAAELAAGEDLKTAVTRGRE 239

Query: 239 WLSSALAQADTLEVGHG 255
           ++   +     L  GHG
Sbjct: 240 FVRRGMETGVRLGRGHG 256


>UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobacillus
           RepID=C6VJ68_LACPJ
          Length = 274

 Score =  165 bits (418), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 103/257 (40%), Positives = 154/257 (59%), Gaps = 5/257 (1%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           TIAGTD  GGAG+ ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q  S+
Sbjct: 9   TIAGTDSGGGAGVMADLKTMQARHVFGTAVVVAVTAQNTLGVQDFMAMPTKLIDEQFASL 68

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
            +D+ I   K GMLA+ + V AV E L+R+    + +D VM+AK G  LL+  A+ T+R 
Sbjct: 69  AADLDIRACKTGMLADAEHVHAVVENLKRFDFGPLTVDPVMIAKGGAALLAADAIKTVRD 128

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD-EQSP 186
            LLP  +++TPNLPEA  L       + Q M++ G SL  +G   V++KGGH D+ + + 
Sbjct: 129 ELLPLATVVTPNLPEAEQLT-GQSITSNQAMVKAGHSLQGLGADNVIIKGGHGDNPDLAN 187

Query: 187 DWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D++   +G     +APRI T  THGTG TLSA + A   +  + A  ++ AK++++  + 
Sbjct: 188 DFVLLADGTAFWLSAPRIDTVRTHGTGDTLSACITAELAKGRSMAAAIKTAKAYVAGTI- 246

Query: 246 QADTLEVGHGIGPVHHF 262
             D ++VGHG GP++H+
Sbjct: 247 -QDGIQVGHGHGPLNHW 262


>UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_BACSU
          Length = 271

 Score =  165 bits (418), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 95/264 (35%), Positives = 146/264 (55%), Gaps = 5/264 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQ--NTRGVQSVYRIEPD 58
           M    ALTIAG+D SGGAGIQADLKTF     YG + +T +VA   N      V+ I+ D
Sbjct: 1   MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAMDPNNSWNHQVFPIDTD 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
            + AQL ++   + +D  K GML   DI+E  A+ ++  Q++NVV+D VM+ K  + +L 
Sbjct: 61  TIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLKNVVIDPVMVCKGANEVLY 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK-G 177
           P     LR +L P  ++ITPNL EA+ L      +T  +M+E  + + A+G   V++  G
Sbjct: 121 PEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDMIEAAKKIHALGAQYVVITGG 180

Query: 178 GHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           G L  E++ D L+  E  +   +  I T  THG GCT SAA+ A   +     + +  AK
Sbjct: 181 GKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTFSAAVTAELAKGAEVKEAIYAAK 240

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
            ++++A+ +  +  +   +GP  H
Sbjct: 241 EFITAAIKE--SFPLNQYVGPTKH 262


>UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochlorococcus marinus
           RepID=Q7V2V2_PROMP
          Length = 262

 Score =  165 bits (418), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 87/245 (35%), Positives = 148/245 (60%), Gaps = 5/245 (2%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           QADL+TF AL  +GCSVIT + AQN+  V+ V  ++ D + +Q+D++FSD  I + K GM
Sbjct: 21  QADLRTFMALKVHGCSVITCVTAQNSVQVKCVEPLKKDTLTSQIDTLFSDFDIKSLKTGM 80

Query: 81  LAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNL 140
           L    I+ A A +L+ + I  ++ D VM++++G  LL  SA+   +  LLP   L+TPN+
Sbjct: 81  LLNDSIINATALKLKSFSIPKII-DPVMVSRTGSKLLEDSAINAYKKLLLPIADLVTPNI 139

Query: 141 PEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR-FT 199
            E A LL     + + ++ +  +S++ +G  AVL+KGG L D +  D+     G ++ F 
Sbjct: 140 FE-ANLLSNLDIKNQVDIEQSAKSIIKLGAKAVLIKGGGLKDMKGRDFYLDVNGGKKWFI 198

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
              I T+NTH +GCTLSAA+   +    +  +++Q++K ++  +L   ++ ++G G GP+
Sbjct: 199 NKFINTQNTHCSGCTLSAAICGYQALGFDLIESIQKSKIFIERSL--KNSYQIGSGPGPL 256

Query: 260 HHFHA 264
            H+ +
Sbjct: 257 GHYQS 261


>UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2V558_NAEGR
          Length = 538

 Score =  164 bits (416), Expect = 2e-39,   Method: Compositional matrix adjust.
 Identities = 111/266 (41%), Positives = 158/266 (59%), Gaps = 17/266 (6%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADL TF A   +G S ITAL AQNT GVQ V+ +  +F+A Q+D
Sbjct: 267 ALTIAGSDSGGGAGIQADLNTFHAHHLFGTSAITALTAQNTLGVQGVFPVSAEFLAKQID 326

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN----VVLDTVMLAKSGDPLLSPSA 121
           SV SD+ I + K GML  ++++  V E+L+ Y+  N    VV+D VM++ SG  LL   A
Sbjct: 327 SVMSDINIVSVKTGMLYSSELIRVVIEKLKHYRELNPNIKVVVDPVMVSTSGHNLLKDEA 386

Query: 122 VATLRSRLLPQVSLITPNLPEAAALL---DAPHARTEQEMLEQGRSLLA--MGCGAVLMK 176
           V  L     P  +LITPN+PEA  +L   D+P   T  E+ ++    ++   G   VL+K
Sbjct: 387 VDALVREFFPMATLITPNIPEAERILELTDSPFKITTVELSKKAAKTISETFGIRNVLVK 446

Query: 177 GGHL-DDEQSPDWLFTREGEQRFT---APRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           GGHL + E + D L+  E + RF    A  I + NTHGTGC+L+AA+A+     +   D 
Sbjct: 447 GGHLINSEYAVDILYESEAD-RFVSLHANFIQSNNTHGTGCSLAAAIASNLALGSTLEDA 505

Query: 233 VQEAKSWLSSALAQA---DTLEVGHG 255
           V+ +K ++ +A+ +       + GHG
Sbjct: 506 VRRSKLYVLNAIVRGFNPSQNQTGHG 531


>UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q6C731_YARLI
          Length = 513

 Score =  164 bits (415), Expect = 3e-39,   Method: Compositional matrix adjust.
 Identities = 102/280 (36%), Positives = 152/280 (54%), Gaps = 28/280 (10%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD-FVAAQ 63
           + LTIAG+D SGGAGI+ADLKT +  G YG + IT L AQNT GV+ ++ IE   F+ A 
Sbjct: 8   SVLTIAGSDSSGGAGIEADLKTITVHGCYGMTTITGLTAQNTTGVEKIHPIEDQGFITAC 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSPSAV 122
           LD+VFSDV +D  K GML+  + +  V   L+++      V+D V+ + SG  L  P+  
Sbjct: 68  LDAVFSDVGVDVVKTGMLSSQETITTVTNYLKKHHANKASVIDPVLCSTSGSTLF-PAEY 126

Query: 123 ATLRSRLLPQVSLITPNLPEAAAL--------LDAPHARTEQEMLEQGRSLLAMGCGAVL 174
            ++   L    +++TPN+PEA  L         + P  +T Q+M +   S+   G   VL
Sbjct: 127 VSVYLELFGLATIVTPNIPEAVELASVLEKKKFETP--KTVQDMKDLAVSIHKTGAKWVL 184

Query: 175 MKGGHLD-------------DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
           +KGGHL              D+   D L+  +       P I TK+THGTGCTL++A+A+
Sbjct: 185 IKGGHLSFTKDKEPAKENDTDKVVIDVLYDGKDFTELVMPYITTKSTHGTGCTLASAIAS 244

Query: 222 LRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
              +  +    V E   ++ +A+ +A  +  GH  GPV+H
Sbjct: 245 NLAKGKDIPQAVLEGTQYIQNAIFEAHPIGKGH--GPVNH 282


>UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfatibacillum
           alkenivorans AK-01 RepID=B8FHR3_DESAA
          Length = 272

 Score =  164 bits (414), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 97/240 (40%), Positives = 139/240 (57%), Gaps = 6/240 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+D   GAGIQADLKTF+ALG YG + ITA+ AQNT GVQ    + PD + AQ+ +
Sbjct: 10  LSIAGSDSGAGAGIQADLKTFAALGVYGTTAITAITAQNTLGVQDWQEVSPDLIVAQIRA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD+R    K GML   + V  VA  ++   ++N+V+D VM AK G  LL   A   + 
Sbjct: 70  VASDMRPKAVKTGMLGGPETVRTVAREIRDLGLENLVVDPVMKAKGGKDLLLQEAYEVMV 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             L P   ++TPNL EA+ L+     +   ++ E  +++  MG  AV++KGGH    Q  
Sbjct: 130 KELFPLARVVTPNLDEASELVGY-DVKDLSQIKEAAKAIQTMGPAAVVIKGGH-SQGQPN 187

Query: 187 DWLFTREGEQRFTAP--RIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           D L+   G + F  P  RI T ++HGTGCT ++A+AA   +     + V  AK + + A+
Sbjct: 188 DLLYN--GSEFFEYPGKRIDTPHSHGTGCTFASAVAAGLAKGMKVREAVFRAKEFTTRAV 245


>UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridia
           RepID=A4XG68_CALS8
          Length = 259

 Score =  162 bits (409), Expect = 1e-38,   Method: Compositional matrix adjust.
 Identities = 88/252 (34%), Positives = 133/252 (52%), Gaps = 4/252 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            L IAG DPS GAGI  D K   +LG +  SVIT L  Q T  V     I+PDF   QL 
Sbjct: 4   VLVIAGFDPSCGAGIVLDTKVVRSLGEFAASVITCLTVQTTERVYDALPIDPDFFEYQLQ 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            +  D+  D+ KIG+L   +I   V   ++RY ++N+V D V+ + SG        V  L
Sbjct: 64  KIIEDIEPDSVKIGLLGSEEITRVVLRNIRRYNLKNIVCDPVLKSTSGFEFGKDKFVEFL 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQ-GRSLLAMGCGAVLMKGGHLDDEQ 184
           +S  L   S+ITPN  EA  + D      E+++L    + +  MG  + ++KGGH+D   
Sbjct: 124 KSEFLKACSVITPNKTEAEVIFDMKIENFEEDILNSIQQKMNKMGIKSCVLKGGHVDGHL 183

Query: 185 SPDWLFTREGEQRFTAPRI-MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           + D L T+    R +A +   T N HGTGC  S+A A    +  N  DT+++ K ++S+ 
Sbjct: 184 AEDVLITQTKIYRVSAKKKGSTDNIHGTGCAFSSAFATFLAKGYNMYDTLKQTKDFVSNL 243

Query: 244 LAQADTLEVGHG 255
           +   +++++G G
Sbjct: 244 I--YNSIKIGKG 253


>UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leotiomyceta
           RepID=C0NXA7_AJECG
          Length = 488

 Score =  160 bits (406), Expect = 3e-38,   Method: Compositional matrix adjust.
 Identities = 98/272 (36%), Positives = 157/272 (57%), Gaps = 18/272 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ +   FV
Sbjct: 1   MKLKRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVVPVGFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++   DV  D  K+GMLA  +  E VA+ L  +++  VVLD VM++ SG  LL   
Sbjct: 61  RKQINAGLEDVGADVVKLGMLASAETAEMVADTLWHHKVSKVVLDPVMVSTSGSELLPAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTE-----QEMLEQGRSLLAMGCGAVLM 175
           AV  ++++LLP  +++TPN+PEA  LL    A T+     ++ ++  + +  +G   VL+
Sbjct: 121 AVNIVQTKLLPLTTIVTPNIPEAILLLQGSGAATKDPENLEDAIQIAKQIHTLGPKYVLL 180

Query: 176 KGGHLDDEQSPDWLFTREGEQRFTAPRIMT-KNTHGTGCTLSAALAALRPRHTNWADTVQ 234
           KGGH+           R   +   + RI   KNTHGTGC+L++A+AA   +  +    V+
Sbjct: 181 KGGHM----------PRTCSRSLASSRISCLKNTHGTGCSLASAIAANLAQGMDVVRAVR 230

Query: 235 EAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            A  ++ + +    ++++G G GP++HFH+ +
Sbjct: 231 AACRFVEAGIRT--SVDMGKGNGPINHFHSVY 260


>UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobacterium
           RepID=Q7P2L0_FUSNV
          Length = 290

 Score =  160 bits (406), Expect = 3e-38,   Method: Compositional matrix adjust.
 Identities = 91/274 (33%), Positives = 154/274 (56%), Gaps = 20/274 (7%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L+IAG+D S GAGIQADLKTF A G YG +VIT+L AQN + V+ +  +  + +  Q+
Sbjct: 16  NVLSIAGSDCSAGAGIQADLKTFVANGVYGMTVITSLTAQNPQKVKMLEDVSIEMLEKQI 75

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++F  + +   KIGML   +  E + + L +Y+ +N+VLD VM+A SG+ L+       
Sbjct: 76  EAIFDVMEVSAVKIGMLNSKENGETIYDELLKYKARNIVLDPVMIATSGNSLIREETKKF 135

Query: 125 LRSRLLPQVSLITPNLPEAAALL-------DAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
           L + L     LITPNL E   ++       +  +  + ++M   G+ +       VL+KG
Sbjct: 136 LVNELFKIADLITPNLDETKEIVKIILNNENIENIDSIEKMKNYGKVIADFTKKWVLIKG 195

Query: 178 GHLDDE-----QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           GHL +       + D ++  EGE      +I + NTHGTGC+LS+A+A+   +  +  D+
Sbjct: 196 GHLSNSAVDILMNKDEIYILEGE------KISSNNTHGTGCSLSSAIASNLAKDYSMLDS 249

Query: 233 VQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           V++AK+++  ++   ++++ G   G V+     +
Sbjct: 250 VKKAKNFVLYSI--KNSIDFGEIAGTVNQMGEIY 281


>UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Desulfovibrionaceae RepID=Q1MQ91_LAWIP
          Length = 277

 Score =  160 bits (405), Expect = 4e-38,   Method: Compositional matrix adjust.
 Identities = 106/265 (40%), Positives = 150/265 (56%), Gaps = 11/265 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKT + LG +G SVITAL AQN  GV  ++  +P F+  QL++
Sbjct: 13  LTIAGSDSGGGAGIQADLKTIAILGGFGLSVITALTAQNGLGVTGIHTPDPSFIELQLNT 72

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           ++    ++  K GML    I+E V   +++ Q    V+D V +++SG  LL  +A+  LR
Sbjct: 73  IYKGFFVNVLKTGMLFSVPIIEIVKNIIKKQQTL-AVIDPVCVSQSGYQLLEHTAIDALR 131

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE--- 183
           + +LP   L+TPN PE A LL      +E+++   G+ L+ MG  AVL+KGGH       
Sbjct: 132 THILPLAMLVTPNKPE-AELLTEMQIESEKDIYIAGKRLIDMGAKAVLIKGGHFYKNNLV 190

Query: 184 -QSPDWLFTREGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
               DW   +        + P I TKN HGTGCTLSAA+A            + +A+++L
Sbjct: 191 TNYVDWYIEKNSTNPIPLSQPAIKTKNNHGTGCTLSAAIATYIGLGLELKKAILQAQTYL 250

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           +  L  + T   G GIGP +H  AW
Sbjct: 251 NYCLKFSYT--PGKGIGPPNH-TAW 272


>UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI00017450E5
          Length = 269

 Score =  160 bits (404), Expect = 5e-38,   Method: Compositional matrix adjust.
 Identities = 104/242 (42%), Positives = 138/242 (57%), Gaps = 3/242 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+D SGGAGIQADLKTF+ALG YG + IT++VA+    V S+  +EPD + AQ+  
Sbjct: 9   LSIAGSDCSGGAGIQADLKTFTALGCYGMTAITSVVAETPAVVDSIQLLEPDIIGAQIRV 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLAKSGDPLLSPSAVAT 124
           +   + +   K GML     +EAV E  Q      V  V+D VM+A SG  LL   A  T
Sbjct: 69  LAKGMPLAAAKTGMLGGRKQIEAVVEAWQPMAQAEVPLVVDPVMVATSGGRLLERDAEET 128

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L   LLP   +ITPNL EAA LL A    +  EML   ++L  +   AVLMKGGHL  + 
Sbjct: 129 LIGHLLPLARVITPNLDEAAVLLGAA-ITSRGEMLSAAQTLAKIHGVAVLMKGGHLAGDA 187

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           +PD L      + +   RI   +THGTGCT SAA+AA         + V   K ++++A+
Sbjct: 188 APDLLVDGTLVRWYEGERISGVHTHGTGCTYSAAIAAGLGSGLGLEEAVALGKKFVTAAI 247

Query: 245 AQ 246
            Q
Sbjct: 248 RQ 249


>UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=O26711_METTH
          Length = 253

 Score =  160 bits (404), Expect = 5e-38,   Method: Compositional matrix adjust.
 Identities = 98/242 (40%), Positives = 141/242 (58%), Gaps = 13/242 (5%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG DPSGGAGI AD+KTFSALG YG  VITAL AQN   V  +  + P FV  QLD
Sbjct: 3   ALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQLD 62

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            V  D+ +   K GML   +IVEAVAE+++ Y ++ V++D VM+A SG  L   + V  L
Sbjct: 63  LVMEDLPVVHAKTGMLYSAEIVEAVAEKVREYGLR-VIVDPVMVAASGGELSEGNFVRAL 121

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMG--CGAVLMKGGHLDDE 183
           R  LLP+  ++TPN+ EA  L D P    +  +    R+   +G  C  V++ GGHL   
Sbjct: 122 RRHLLPEALIVTPNVAEAERLSDIPIGTVDDAI----RAARVIGELC-DVIITGGHLGGR 176

Query: 184 QSPDWLFTREGEQRFTAPRIM-TKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
                +   +G+      +++ ++NTHG+GC+ SAA AA   R  +  + ++ A  ++  
Sbjct: 177 S----VILIDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVRE 232

Query: 243 AL 244
           A+
Sbjct: 233 AI 234


>UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanospirillum hungatei
           JF-1 RepID=Q2FLY4_METHJ
          Length = 257

 Score =  159 bits (402), Expect = 9e-38,   Method: Compositional matrix adjust.
 Identities = 91/242 (37%), Positives = 143/242 (59%), Gaps = 4/242 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DPSGGAGIQ DLKTF+  G +G +VITAL AQN   V   + ++P+ V  Q+ 
Sbjct: 8   ALTIAGSDPSGGAGIQMDLKTFAKTGVWGMAVITALTAQNAAQVTGSWPMDPEMVREQII 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D+     K GMLA T+I++AV E + +     +V+D VM++ SG  LL+  A+  +
Sbjct: 68  AVLEDLTPGAIKTGMLANTEIIKAVEETVPKD--VPLVIDPVMISTSGYRLLNDDAICDI 125

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
             RL+P   LITPN+PE A ++      ++++++  G  ++ +G   VL+KGGH   + +
Sbjct: 126 CERLIPLAHLITPNIPE-AEIISQMKIASDEDVILAGSKIMDLGAKQVLIKGGHGKGDDA 184

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D+L  +EG   F   R +  + HG+GC LSAA+     +  +     ++AK  ++  + 
Sbjct: 185 IDYLIMKEGNISFRHTR-LPYDVHGSGCCLSAAITGYIAQGFDDISCCKKAKDLVTFGIR 243

Query: 246 QA 247
            A
Sbjct: 244 HA 245


>UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular organisms
           RepID=A1RUE5_PYRIL
          Length = 450

 Score =  158 bits (400), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 96/254 (37%), Positives = 143/254 (56%), Gaps = 11/254 (4%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    ++P  V AQ+ 
Sbjct: 6   AMTIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLQPPLVRAQIL 65

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  AV TL
Sbjct: 66  AVWDDMGIDAGKTGMLGTREIIEEVAATVSKLGFP-LVVDPVMIAKSGAPLISEDAVDTL 124

Query: 126 RSRLLPQVSLITPNLPEAAAL-----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           + RLLP   ++TPN  EA  L          AR   E++ +       G   V++KGGHL
Sbjct: 125 KKRLLPVAKVVTPNRHEAEKLTGIKITSVAEARRAAEVIHR-----EFGTEVVVVKGGHL 179

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D  ++ D ++          PR+ ++ THGTGC+ SAA+AA   +     + ++ AK ++
Sbjct: 180 DAPEAVDVVYIGGTFHELATPRLDSRATHGTGCSYSAAIAAGLAKGLPPLEAIKTAKRFI 239

Query: 241 SSALAQADTLEVGH 254
             A+        GH
Sbjct: 240 YMAIRYGVARGKGH 253


>UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobaculum
           RepID=A4WJ58_PYRAR
          Length = 449

 Score =  158 bits (400), Expect = 2e-37,   Method: Compositional matrix adjust.
 Identities = 94/249 (37%), Positives = 144/249 (57%), Gaps = 1/249 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    + P  V +Q+ 
Sbjct: 5   AITIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLAPSLVRSQIM 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  AV  L
Sbjct: 65  AVWDDMGIDAGKTGMLGTREIIEEVASTVSKLGFP-LVVDPVMVAKSGAPLISDDAVDVL 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R RLLP   ++TPN PEA  L     A  +             G   V++KGGHL+  ++
Sbjct: 124 RRRLLPVAKVVTPNRPEAERLTGMKIASEKDAERAAEYINKEYGTEVVVVKGGHLEGAEA 183

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D ++ +    +F+ PR+ ++ THGTGC  SAA+AA   +  +  + ++ AK ++ +A+ 
Sbjct: 184 VDVVYYKGSFHKFSTPRLESRATHGTGCAYSAAIAAALAKGLDPLEAIKTAKRFIYTAIK 243

Query: 246 QADTLEVGH 254
              +   GH
Sbjct: 244 YGVSRGKGH 252


>UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6K2F3_SCHJY
          Length = 505

 Score =  157 bits (398), Expect = 3e-37,   Method: Compositional matrix adjust.
 Identities = 92/279 (32%), Positives = 153/279 (54%), Gaps = 24/279 (8%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            +T+AG+D SGGAGIQADLK FSA   YG + +TA+ +QNT GV  V+ + P  V  Q++
Sbjct: 5   CITVAGSDCSGGAGIQADLKVFSAHSVYGMNAVTAITSQNTVGVNGVFPVPPAVVKKQIE 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +  +D+  +  K GML   +I++ + + +  + I++V+ D ++  K G  L+ P  V   
Sbjct: 65  ACLTDIECNVLKTGMLFTKEILDVLIDVINNFHIKHVIADPLISTKKGMLLVKPEYVKVF 124

Query: 126 RSRLLPQVSLITPNLPEAAALLD-------APHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
            ++ +P   LITPNL EA  LL          H  ++ E++   + L+A GC +VL+K  
Sbjct: 125 VTKFIPLTELITPNLSEALILLKQLTGETIGVHNASDVELI--AKKLVAAGCKSVLIKCN 182

Query: 179 HL--DDE-------QSPDWLFTREGEQRFTA--PR--IMTKNTHGTGCTLSAALAALRPR 225
           +L  DD+        S  W     G+ + +   P+  +  ++ HGTGCTL++A+AA R  
Sbjct: 183 NLWFDDDLKCTSNKDSAVWFVYVYGDAKTSKIIPKKWLAARSAHGTGCTLASAIAANRAN 242

Query: 226 HTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
             +  D    A +++ +AL +  + ++GHG   + H  A
Sbjct: 243 GLSLYDAALNAAAYVQAALEK--SFQLGHGANSLDHVFA 279


>UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobacillales
           RepID=A8YTJ6_LACH4
          Length = 270

 Score =  157 bits (397), Expect = 4e-37,   Method: Compositional matrix adjust.
 Identities = 96/261 (36%), Positives = 136/261 (52%), Gaps = 5/261 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+TIAG D  G AG+ ADL  F   G YG  ++TA VA NT G+ +   +  DF+  Q D
Sbjct: 8   AVTIAGNDSDGSAGMPADLHAFYDRGVYGMGLMTAAVAGNTTGIFAQQIMPVDFIQKQFD 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            +  D +I   K GMLA  +I++ VA+ L++Y +  +VLD V++ K G  LL   A  T 
Sbjct: 68  VLNDDFKISAAKTGMLANKEIIDCVADNLEKYDMGKIVLDPVIITKHGATLLDDDAYQTF 127

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDEQ 184
             +LLP   +ITPN  E   L        ++E+    + L  MG   VLMKG H  D  +
Sbjct: 128 LDQLLPLADVITPNFYEQQKLT-GMKLENKEEIHAGAKKLQEMGAKNVLMKGRHDADQAE 186

Query: 185 SPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
             D L T +G    FT P   T   +GTG TLSA +AA   +  +  D V+  K +   A
Sbjct: 187 VADILLTEDGNFHEFTKPHFKTDRVNGTGDTLSAVIAAELAKGKSIIDAVKIGKDFTYEA 246

Query: 244 LAQADTLEVGHGIGPVHHFHA 264
           ++    + VG   GP++H+ A
Sbjct: 247 ISHP--INVGSKWGPINHWAA 265


>UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=D1UAF8_9DELT
          Length = 458

 Score =  156 bits (394), Expect = 8e-37,   Method: Compositional matrix adjust.
 Identities = 111/260 (42%), Positives = 139/260 (53%), Gaps = 5/260 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKT + LG YG SVITAL AQNTR V  +      FVA QL +
Sbjct: 8   LTIAGSDSGGGAGIQADLKTIAMLGGYGASVITALTAQNTRAVTGIQAPTAKFVARQLQT 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+++D  K GML    I+ A+A  L   +   +V+D V +A SG  LL   AV  + 
Sbjct: 68  VLDDIQVDGAKTGMLFSEPIIRAIAPILSARRFP-LVVDPVCVATSGAKLLKAEAVDAMV 126

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             + P   L+TPN PE A L      R   ++    R LL MG  AVL+KGGH D     
Sbjct: 127 DLIFPLADLVTPNRPE-AELFTGVEIRDRDDVFRAARILLDMGPRAVLIKGGHADSLAVT 185

Query: 187 DWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           DW      E   F   R+ T  THGTGCTLSAA+A    +       +  A+ +L+ AL 
Sbjct: 186 DWFVAAGAEPVPFMQQRVDTACTHGTGCTLSAAIATGLGQGMEMDAAILRAQKYLNLALR 245

Query: 246 QADTLEVGHGIGPVHHFHAW 265
            A    +G G GP +H   W
Sbjct: 246 AA--YRLGEGGGPPNHLAPW 263


>UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=C8WXY2_ALIAD
          Length = 297

 Score =  155 bits (391), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 110/257 (42%), Positives = 146/257 (56%), Gaps = 4/257 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKT      YG SV+TA+ AQNT GVQ+VY +  D V AQ +S
Sbjct: 13  LTIAGSDSGGGAGIQADLKTAHQFDVYGMSVLTAVTAQNTVGVQAVYPLPVDIVRAQFES 72

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+  D  K GML +   + AVA+ L       +V+D VM+AK G+ LL P  VA + 
Sbjct: 73  VRDDLGFDAIKTGMLGDRAAIHAVADALAGVDCP-IVVDPVMIAKGGEALLHPDDVAAVI 131

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQ 184
            R+LP   + TPN PEA  L   P  R+  +      +L  +G    ++KGGHL+     
Sbjct: 132 ERMLPLAFVATPNTPEAERLTGIP-IRSLADAARAAEALAGLGAQYAVVKGGHLEGAGHL 190

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D +F       F APR+ +  THGTGCT S+A+AA   R     + +  AKS++S A+
Sbjct: 191 AIDVVFHDGAWTFFAAPRVPSHKTHGTGCTFSSAIAACLARGARPLEAIAAAKSFISRAI 250

Query: 245 AQADTLEVGHGIGPVHH 261
           A A   +VG G GP  H
Sbjct: 251 AAAADWDVGRGHGPTDH 267


>UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F2B9_9PROT
          Length = 253

 Score =  154 bits (389), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 106/252 (42%), Positives = 135/252 (53%), Gaps = 11/252 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   LTI G+D  GGAGIQADL+ F  LG YGCS ITAL AQN      + RIEP  +
Sbjct: 6   MARPVCLTIGGSDSCGGAGIQADLRVFDRLGVYGCSAITALTAQNPL---HIARIEPVSL 62

Query: 61  A---AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
           A   A+L ++F    +   K GML + + V  V+  L      ++V+D VM++ SG  LL
Sbjct: 63  AQLDAELHALFDYYDVAVVKTGMLLDAEHVAVVSGLLAELHHGSLVVDPVMISSSGSVLL 122

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMK 176
               VA LR  LLPQ +LITPNL EA ALL  P        +E  ++L  A+GC  VL+K
Sbjct: 123 DQGGVAALRGALLPQAALITPNLDEADALLGQPSGYAADSPVEAVKALREALGC-PVLLK 181

Query: 177 GGHLDDEQSPDWLF-TREGEQRFTAPRIM--TKNTHGTGCTLSAALAALRPRHTNWADTV 233
           GGH D +   D L    EG  RFT  R        HGTGC L++A+AA           V
Sbjct: 182 GGHADGDMLLDLLCDEEEGIHRFTHIRQCWSAGEGHGTGCRLASAVAAGLANQMPLVPAV 241

Query: 234 QEAKSWLSSALA 245
           + A ++L    A
Sbjct: 242 EAAIAFLQECTA 253


>UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A1A9_NATTJ
          Length = 275

 Score =  154 bits (389), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 86/237 (36%), Positives = 136/237 (57%), Gaps = 7/237 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF ++G +G +V+T + AQNT GVQ+   +E   VA Q  SV  D+ I   K G
Sbjct: 21  IQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVAEQFKSVAEDMEISAVKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML+   I+E V++ L  +  +  +V+D V+ A SGD LL   AV+TL  +L+P   +ITP
Sbjct: 81  MLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQAVSTLLEKLIPISDIITP 140

Query: 139 NLPEAAAL--LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQ 196
           N+PEA  L  ++  H++   ++ +    L   G  +VL+KGGH     + D  F  +   
Sbjct: 141 NIPEAEILTGINIDHSK---DLQKAAHKLKEAGAKSVLIKGGHTSG-NATDHFFWEDEYH 196

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVG 253
            F+A R+   + HGTGCTL +A+ A   +  +   +++ AK +++ A+  + T+  G
Sbjct: 197 TFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYVTQAINNSFTIGEG 253


>UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomonadaceae
           RepID=Q3BUP8_XANC5
          Length = 295

 Score =  154 bits (388), Expect = 4e-36,   Method: Compositional matrix adjust.
 Identities = 103/242 (42%), Positives = 148/242 (61%), Gaps = 3/242 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           ++AL+IAG+D  GGAGIQADLKTF+A   +G S ITAL AQ+TR V +V+     F+ AQ
Sbjct: 33  LSALSIAGSDSGGGAGIQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLSFLQAQ 92

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+ F+D  I   K+GMLA  D++  VA+ L+RY+   VVLD VM++ SG  LL  +A+ 
Sbjct: 93  VDACFADFEIQAVKLGMLANADVIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALD 152

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD- 182
            LR+RLLP  +L+TPN PE A LL      +         +LL +G  AVL+KGGHL + 
Sbjct: 153 ALRTRLLPLATLVTPNTPE-AELLTGRRIDSADAAEHATAALLDLGANAVLLKGGHLHEG 211

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            +  D       +  F  PR+   + HGTGC+LSAA+AA   +  +  +  + A  +++ 
Sbjct: 212 ARVLDRFDDGVTQDVFMHPRLQV-DAHGTGCSLSAAIAAQLCQGLSLLNACEAAIDYVAR 270

Query: 243 AL 244
           A+
Sbjct: 271 AI 272


>UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase);
           hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)
           n=10 Tax=Actinomycetales RepID=Q0RDL7_FRAAA
          Length = 291

 Score =  153 bits (387), Expect = 5e-36,   Method: Compositional matrix adjust.
 Identities = 96/244 (39%), Positives = 141/244 (57%), Gaps = 5/244 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  A G +G S + A+ AQN+ GV  V+ +  + V AQ+ +V  D+ +D  K G
Sbjct: 49  IQADLKTMLAFGVHGMSAVVAVTAQNSLGVHGVWDLPAEAVRAQIRAVVDDIGVDAVKTG 108

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+   +V  VA  L+R     +V+D V ++K GDPLL+P AV  +R  L+P  ++ TPN
Sbjct: 109 MLSSAALVALVATELERVG-APIVVDPVGVSKHGDPLLAPDAVDVVRRELMPLATIATPN 167

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L E   LL     R E ++     ++LA+G   VL+KGGHL  + + D L     E    
Sbjct: 168 LDE-VRLLTGVAVRDETDLPRAAAAMLALGPRWVLIKGGHLPGD-AVDLLTDGSTEILLR 225

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + R+  ++THGTGCTL++A+A+   R  +    V+ AK ++S ALA      +G GIGPV
Sbjct: 226 SRRMDRRHTHGTGCTLASAIASRMARGDSPTQAVRAAKEYVSGALAAG--FPLGAGIGPV 283

Query: 260 HHFH 263
            H +
Sbjct: 284 DHGY 287


>UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3DWC5_METI4
          Length = 280

 Score =  153 bits (386), Expect = 6e-36,   Method: Compositional matrix adjust.
 Identities = 83/239 (34%), Positives = 134/239 (56%), Gaps = 2/239 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L I G+D S GAGIQ DLK  + LGAY  +VIT +VA++   V+S+Y +    + +Q  S
Sbjct: 28  LIIGGSDCSCGAGIQGDLKIITCLGAYATTVITCVVAEHPGRVESLYHLPSSIIESQFHS 87

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATL 125
           +     ID  KIGML + ++ + + E +++++I   +V+D V+ A +GD L  P     L
Sbjct: 88  ILDFFPIDAIKIGMLYKKELPQKIVELIRKFKINAPIVVDPVLAAGNGDSLAEPGMEEEL 147

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
              L P  +++TPN+ E A LL      + ++ML   + L      + L+KGGHL D+ +
Sbjct: 148 ARNLFPLATVVTPNI-EEAELLSGLRIESPEDMLRVAQDLSEQYSTSFLIKGGHLQDKTT 206

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D L+ +    +F  PRI+  N HGTGC+L++A A    +  +    V++AK+ L   +
Sbjct: 207 IDVLYHKGIAHKFELPRILHANPHGTGCSLASATAVFLAQGLDLPKAVEKAKAKLYEKI 265


>UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3 Tax=root
           RepID=Q1EI25_9ZZZZ
          Length = 284

 Score =  153 bits (386), Expect = 7e-36,   Method: Compositional matrix adjust.
 Identities = 105/257 (40%), Positives = 149/257 (57%), Gaps = 21/257 (8%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT +ALG Y  + +TAL AQNTRGV S++ +  DFVA Q+  V SD+  D  K+G
Sbjct: 27  IQADIKTVTALGGYAMTAVTALTAQNTRGVFSIHDVPADFVAEQMRVVLSDIGADCVKVG 86

Query: 80  MLAETDIVEAVAERLQRYQIQN-------VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQ 132
           ML    ++EAV + L+             +V+D VM+AK G+ LL+P A+A+L++R++P 
Sbjct: 87  MLHTPGVIEAVCDVLEAEAEAAAGGRRVPIVVDPVMVAKGGESLLAPDAMASLKARMIPL 146

Query: 133 VSLITPNLPEAAAL----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDW 188
             ++ PN+ EA AL    +  P      +     R L A G  AVL+KGGHL  E   D 
Sbjct: 147 AHVLMPNVAEAEALTGLTVGGP-----DDAGTVARKLAAAGAAAVLLKGGHLPGETVIDI 201

Query: 189 LFTREGE--QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           L   +GE  + F +PRI T +THGTGCTL++A A    +     D V  A+ ++  A+  
Sbjct: 202 LAV-DGEIVEVFESPRIDTPHTHGTGCTLASATATGLAQGMAVRDAVARARRYVHEAILT 260

Query: 247 ADTLEVGHGIGPVHHFH 263
           A  L  GHG GP++H H
Sbjct: 261 APGL--GHGHGPLNHAH 275


>UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermoplasmatales
           RepID=Q97BE3_THEVO
          Length = 266

 Score =  152 bits (385), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 97/263 (36%), Positives = 151/263 (57%), Gaps = 9/263 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D  GGAGIQADLKTF++L  +G SVITA+ AQN+  V  +  + P+FV  Q+
Sbjct: 5   KALTIAGSDSGGGAGIQADLKTFNSLSVFGMSVITAVTAQNSYEVSGILPVPPEFVKLQI 64

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+V  D+++D  K GML  ++I++ V   ++ Y I+ V++D VM++KS   LL   A+ +
Sbjct: 65  DTVAKDIKVDGAKTGMLFSSEIIKVVTGSIKDYSIKPVIVDPVMVSKSNARLLREDAIES 124

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKGGHLDDE 183
           L   LLP+ +++TPN+PEA  L  A  + +  E ++     +    G  VL+KGGH +  
Sbjct: 125 LIKYLLPESTIVTPNIPEAEIL--ASMSISTIEDMKAAAEKIGTEIGLKVLVKGGHFNGP 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              D  +      +F   R  TKNTHGTG TLS+A+ +   +     + +   K ++  +
Sbjct: 183 PI-DIYYDGSNILKFEGTRYETKNTHGTGDTLSSAILSFLIKGYREQEAIALGKEYVEGS 241

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           +   ++   G G G + H   WW
Sbjct: 242 I--RNSFPTGSGFGSLCH---WW 259


>UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadratum walsbyi DSM
           16790 RepID=Q18GX7_HALWD
          Length = 273

 Score =  152 bits (385), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 103/265 (38%), Positives = 146/265 (55%), Gaps = 18/265 (6%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIA +D SGGAGIQADLKT +  G YG SV+ +  AQNT+GV S + + P  +  QL+
Sbjct: 11  ALTIASSDSSGGAGIQADLKTMTRFGVYGGSVVVSTTAQNTQGVDSTHVLPPAEIRTQLE 70

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SV  D+ ID  K+GMLA  + +E V + L  Y    VV+D VM+A SGD LL+ +A+  +
Sbjct: 71  SVAEDIDIDAIKLGMLATAEAIETVDDCLMGYD-GPVVIDPVMVATSGDRLLAENAI-DV 128

Query: 126 RSRLLPQVSLITPNLPEAAALL----DAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
            + L    +L+TPN  E  AL     D   AR         +     G  AVL KGGH++
Sbjct: 129 YTDLFAHATLLTPNADETEALTGVWPDTVEARERA-----AKQFFDWGVDAVLFKGGHIE 183

Query: 182 DEQSP--DWLFTRE-GEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            +++   D L   + G Q   T  R+ T +THG+GCTL++A+AA      +    V +  
Sbjct: 184 TDENTVQDILIGADAGTQLTITGDRVETAHTHGSGCTLASAIAAGLAHDVDIETAVSDGV 243

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++ +AL  A T+      G V+H 
Sbjct: 244 EFVQTALQNAATIGAN---GSVNHL 265


>UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosarcinales
           RepID=A0B7E3_METTP
          Length = 452

 Score =  152 bits (384), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 111/273 (40%), Positives = 158/273 (57%), Gaps = 23/273 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+R + LT+ G+D  GGAGIQADLKTF+ALG +G SVITA+ AQNT GV+ V+ I  + +
Sbjct: 1   MER-SVLTVGGSDSGGGAGIQADLKTFAALGVHGLSVITAVTAQNTLGVREVFPIPAEMI 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A+QLD++  D  I   K GML   D +  VAERL+  +  +VV+D V+ A++G  L++  
Sbjct: 60  ASQLDALVEDFDISWAKTGMLFSPDAISLVAERLRELRC-SVVVDPVIAAEAGGSLIAEG 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAAL-----LDAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           A+ TLR  L+P  S+ITPN+ EA A+     +D   AR      E    +L MG  AV++
Sbjct: 119 AILTLRDELIPVASVITPNIFEAEAITGVKVVDLESAR------EAAMRILDMGARAVVI 172

Query: 176 KGGHLD-------DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
            GGHLD        ++  D L T++     +  R    N HG GCT SAAL AL     +
Sbjct: 173 TGGHLDCRAAGMPADECVDLLVTKDAVACVSGKRREGGN-HGVGCTYSAALTALLSMGMS 231

Query: 229 WADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
             D V++A ++ + ++    +  VGHG  PV  
Sbjct: 232 LDDAVRQAHNFAARSI--EGSRPVGHGAAPVDQ 262


>UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes RepID=B2AXQ5_PODAN
          Length = 532

 Score =  152 bits (383), Expect = 2e-35,   Method: Compositional matrix adjust.
 Identities = 102/283 (36%), Positives = 162/283 (57%), Gaps = 26/283 (9%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT GV  ++ +  +F+  Q+D+
Sbjct: 7   LVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTLGVHGIHHVPAEFLRKQIDA 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  +     TK GM+A    +EAVAE ++ Y+++ VV+D VM+A +G PLL  ++++ LR
Sbjct: 67  VGLNCTDCKTK-GMMASAGTIEAVAEVIREYKLKTVVVDPVMVATTGSPLLPNTSLSLLR 125

Query: 127 SRLLPQVSLITPNLPEAAALL-DAPHARTEQEMLEQ----GRSLLAMGCGAVLMKGGHL- 180
            +L+P  +++TPNLPEA  LL DA       E +       R++ ++G   VL+KGGH  
Sbjct: 126 EKLVPLATVLTPNLPEARLLLADAGFGHLPVEKVSDLEGIARAVGSLGPKWVLIKGGHCP 185

Query: 181 ------------DDEQSPDWLFTRE---GE--QRFTAPRIMTKNTHGTGCTLSAALAALR 223
                         E+  D L+ R+   GE  ++   P   +K+THGTGC+L++A+A   
Sbjct: 186 FNGEGMIAAEEGKREKVVDVLWGRDEKGGEVLRQVETPYWESKHTHGTGCSLASAIACNL 245

Query: 224 PRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            +  +    V+ A  ++ + +  A  L  G G GP++HFH+ +
Sbjct: 246 AKRMDMPQAVEAACRYVEAGIKTAPGL--GKGNGPLNHFHSTY 286


>UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobacteriaceae
           RepID=Q11F75_MESSB
          Length = 256

 Score =  152 bits (383), Expect = 2e-35,   Method: Compositional matrix adjust.
 Identities = 96/248 (38%), Positives = 144/248 (58%), Gaps = 3/248 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + L +AG+D SGGAG   D++  ++LG      ITA+ AQ    V +V  + P  V+A
Sbjct: 4   RPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++      ID  KIGML  +DIVEAV+  L+R+    VVLD V+ + SG  L+  + +
Sbjct: 64  QMEAALEAEPIDAIKIGMLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A L+  LLP   L+TPN  E A L     A +E+E L+QG  LLA GC A+L+KGGH  D
Sbjct: 124 AVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALDQGNLLLASGCHALLVKGGHAPD 183

Query: 183 EQSPDWLFTREGE--QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +++   +  R G   +RF APR+ ++   GTGC L++++AA   R  +  +++   K  +
Sbjct: 184 KRNSTDILLRRGHAPERFEAPRLDSR-MRGTGCALASSIAAALARGLSLEESIAFGKRKV 242

Query: 241 SSALAQAD 248
              L +AD
Sbjct: 243 YHLLREAD 250


>UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase n=3
           Tax=Methanosarcinaceae RepID=Q12U29_METBU
          Length = 456

 Score =  151 bits (382), Expect = 2e-35,   Method: Compositional matrix adjust.
 Identities = 97/258 (37%), Positives = 157/258 (60%), Gaps = 10/258 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGI+AD+KT ++L  +G   IT++ +QNT GVQS Y + P  V+ Q+D+
Sbjct: 18  LTIAGSDSGGGAGIEADIKTLASLYVHGACAITSVTSQNTTGVQSAYELPPTVVSDQMDA 77

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V +D+ +   K GML+  +IV AVA+R+++Y ++ VV+D VM A++G  LL   AV+ L+
Sbjct: 78  VCTDMDVRWAKTGMLSSANIVRAVADRVKKYGLK-VVVDPVMAAEAGGDLLEKDAVSILK 136

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP    +TPN+ E A +L      T ++ +E  +++ ++G  AV++ GGH D     
Sbjct: 137 DELLPISYAVTPNISE-AEILSGMSITTREDAMEAAKAIASLGLNAVIITGGHSD---GV 192

Query: 187 DWLFTREGEQRFT--APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           D ++    ++ FT  + +++   THG+GCT SAAL +   R  +  D    AK ++ S +
Sbjct: 193 DLVYDSVTDE-FTEVSGKLIEGGTHGSGCTYSAALTSYLARGYSLQDAAIGAKEFVESGI 251

Query: 245 AQADTLEVGHGIGPVHHF 262
             +    +G G+GPV+  
Sbjct: 252 LLSKN--IGKGVGPVNQM 267


>UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodesulfovibrio
           yellowstonii DSM 11347 RepID=B5YFN2_THEYD
          Length = 254

 Score =  150 bits (380), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 82/251 (32%), Positives = 140/251 (55%), Gaps = 5/251 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTI  +DP+ GAGIQ DLK F +L  YG S++TA+ AQ+T    SV+ +  + + +Q +
Sbjct: 4   ALTIGASDPTSGAGIQMDLKVFHSLEVYGLSILTAVTAQSTIEFSSVFPLPEEIINSQFE 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D++   TKIGM+   +  + V   ++   I+N+V+D VM +  G  LL  +A+ TL
Sbjct: 64  TLLKDLKPHGTKIGMIYSKEAFQCVISNIKNLNIKNLVIDPVMTSTLGAKLLENNALKTL 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +  L+P    +T N+PEA AL +    R E ++ E  + L  MG    ++KGGH  ++++
Sbjct: 124 KEELIPLSMAVTANIPEAEALTELKIERIE-DLYEASKQLYQMGTKFAIIKGGHF-EKKA 181

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L+  +   +    +I     HGTGC  S+A      +  N  +  + +K ++  A+ 
Sbjct: 182 IDILYDGKNFYKIDGKKI-PGQFHGTGCAFSSAFVCFLCKGYNPLEAFKASKDFVRKAI- 239

Query: 246 QADTLEVGHGI 256
             ++L++G GI
Sbjct: 240 -ENSLKLGQGI 249


>UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=B8IYN0_DESDA
          Length = 269

 Score =  150 bits (380), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 107/259 (41%), Positives = 145/259 (55%), Gaps = 6/259 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D  GGAGIQADLKT  ALG YG SVI AL AQN +GV  ++  +PDFVA QL
Sbjct: 6   NILTIAGSDSGGGAGIQADLKTIMALGGYGMSVIAALTAQNGQGVTGIHAPDPDFVALQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V     +   K GML    I++A+A  L++     +V+D V +++SG  LL   AV  
Sbjct: 66  CTVLDGFPVAAAKTGMLFSAPIIKAIAPILRKRDFP-LVVDPVSISQSGSVLLQEDAVKA 124

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L   +LP   L+TPN PEA  L +      + +    G  LL MG  AVL+KGGH++   
Sbjct: 125 LVQEILPGCDLLTPNRPEAEMLTNMTIDNLD-DAAAAGEKLLQMGARAVLIKGGHMESNV 183

Query: 185 SPDWLFTREGE--QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
                   EG+  +     ++ T N HGTGCTLSAA+A    +       V  A+ +L+ 
Sbjct: 184 VVTDCLCMEGQAPKHLPQAKVETVNNHGTGCTLSAAIATGLGKGLPLQVAVTRAQEFLNL 243

Query: 243 ALAQADTLEVGHGIGPVHH 261
           AL +  +   G+G GPV+H
Sbjct: 244 ALRR--SYSPGNGCGPVNH 260


>UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=21
           Tax=Bacteria RepID=Q03NS0_LACBA
          Length = 272

 Score =  149 bits (377), Expect = 8e-35,   Method: Compositional matrix adjust.
 Identities = 97/258 (37%), Positives = 148/258 (57%), Gaps = 5/258 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAGTD  GGAGI ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q  S
Sbjct: 10  LTIAGTDSGGGAGIMADLKTMQACQVFGAAVVVAVTAQNTLGVQDFMALPQKLIDEQFAS 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + +D++I   K GMLA+   V  V E L++Y    + +D VM+AK G  LL+  AV T+R
Sbjct: 70  LAADLKIRACKTGMLADAAHVHGVVENLKKYDFGLLTVDPVMIAKGGAALLADDAVTTVR 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDEQS 185
             L+P   ++TPNLPEA  L         + M     +L  +G   V++KGGH    +Q+
Sbjct: 130 DELVPLADVLTPNLPEAERLT-GLTITDNRGMEAAAMALQDLGAKNVVIKGGHEATPDQA 188

Query: 186 PDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D++   +G     +A R+ T  THGTG TLS+ + A   +  ++   ++ AK ++++A+
Sbjct: 189 SDFVLLVDGRSFWLSAARMDTVRTHGTGDTLSSCITAALAKGEDFETAIRIAKDFVTAAI 248

Query: 245 AQADTLEVGHGIGPVHHF 262
             A+ + VG+G GP++H+
Sbjct: 249 --ANPIAVGNGHGPLNHW 264


>UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynthesis protein thiN
           n=5 Tax=cellular organisms RepID=B0R885_HALS3
          Length = 445

 Score =  149 bits (377), Expect = 8e-35,   Method: Compositional matrix adjust.
 Identities = 116/266 (43%), Positives = 150/266 (56%), Gaps = 20/266 (7%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLKTF A  A+G S ITA+ AQNT GV     + P+ V AQ+D
Sbjct: 5   ALTIAGSDSGGGAGIQADLKTFEAGDAFGTSAITAVTAQNTHGVTHSDILAPETVRAQID 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V +D  +   K GML +  +V+AVA  L       V +D V++++SGD LL+ S +A +
Sbjct: 65  AVTTDFDVSAVKTGMLGDAAVVDAVATALAETP-APVTVDPVVVSQSGDRLLTESGIAAV 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLP+ +L TPN+PEA  L D      E ++     ++  +G  A L+ GGHLD +  
Sbjct: 124 RDELLPRATLATPNIPEAELLADT-EITDETDLRAAAEAVCELGPDATLLTGGHLDGD-- 180

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALA-------ALRPRHTNWADTVQEAKS 238
           P  +F  +    FT PRI T  THG+GCTLSAA+        ALRP      D V     
Sbjct: 181 PVDVFAGDTTSAFTRPRIETPTTHGSGCTLSAAITARLAHGDALRPAVERGIDAV----- 235

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
               A A    L VG G GPV H HA
Sbjct: 236 ----AAAIDGDLSVGGGDGPVDHRHA 257


>UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella succinogenes
           RepID=Q7M9P0_WOLSU
          Length = 261

 Score =  149 bits (375), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 92/260 (35%), Positives = 141/260 (54%), Gaps = 13/260 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGIQAD+KT  A G +  + +T + AQNT GV+    +    V +Q+++
Sbjct: 5   LTIAGSDSSGGAGIQADIKTAEAFGCFSATALTVITAQNTLGVREAMPLGASLVRSQIEA 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-----VVLDTVMLAKSGDPLLSPSA 121
           V  D  ++  KIGML +T+ +  V E    + IQN     VVLD V ++++G  LL   A
Sbjct: 65  VMEDFSVEAIKIGMLYDTETILGVGE----FLIQNALKIPVVLDPVAISQAGSKLLLDEA 120

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           + +L + L P  +++TPNL E     +     T + + E+G         A ++K    +
Sbjct: 121 IRSL-ADLFPLATVVTPNLKETELFWNLDQEPTLEILRERGVEFARERGVAFVVKNLRKE 179

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           D +S D+L   EG   F  P +    +HGTGC+ S A+A L     +  + V+EAK ++ 
Sbjct: 180 D-RSVDYLIQEEGIASFCTPYVKNGQSHGTGCSFSMAIACLLALGLSLPEAVKEAKDYIY 238

Query: 242 SALAQADTLEVGHGIGPVHH 261
            A+ +A  L  G G GP+ H
Sbjct: 239 KAMLEAPFL--GRGAGPILH 256


>UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SM66_NOCSJ
          Length = 270

 Score =  148 bits (374), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 97/260 (37%), Positives = 143/260 (55%), Gaps = 8/260 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALT+AGTD  G AG+ ADL TF+ALGA+G   +TA+ AQ+T GV +V  +  D V AQ+D
Sbjct: 7   ALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADHVRAQVD 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D+ +   K GML   +I   VA+      +   V+D V+   SG  L   + VA  
Sbjct: 67  AVLDDLPVAVAKAGMLGSAEIAGVVADLPPGLPL---VVDPVLRTTSGSVLADDALVAAY 123

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  +LP+ +++TPNL EA  L     A +E+ +    R+L A+G  AV++ GG  + +  
Sbjct: 124 RDHILPRCTVVTPNLAEARRLAG---AGSEEPLEHVARALQALGP-AVVLTGGDPESDWC 179

Query: 186 PDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D++    G       P + T N HGTGCT SAALA    R        + A++++++AL
Sbjct: 180 RDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAAL 239

Query: 245 AQADTLEVGHGIGPVHHFHA 264
            ++    +G G GPV H  A
Sbjct: 240 RRSAGWRLGRGRGPVAHTFA 259


>UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphilium cryptum JF-5
           RepID=A5FWQ5_ACICJ
          Length = 272

 Score =  148 bits (374), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 92/249 (36%), Positives = 138/249 (55%), Gaps = 12/249 (4%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           +AD+KT +ALG Y  + ITA+ AQ+T G+ ++  + PD VA  +  V +D+ +D  K+GM
Sbjct: 21  EADVKTITALGGYAMTAITAVTAQDTSGIAAIAPVPPDLVARSIRMVVADLGVDAIKLGM 80

Query: 81  LAETDI-VEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           L       E             +VLD V+ + SG  L    A+A +R RLLP+ +L+TPN
Sbjct: 81  LGSAGTAEEVALAIAAAAPAAPLVLDPVLASTSGTALAGEGALAIIRDRLLPRATLVTPN 140

Query: 140 LPEAAAL----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE 195
             EAA L    +D     + ++ +  GR+L  +G  AVL+KGGH D +   D L   +  
Sbjct: 141 RDEAATLAGLAID-----SHEDAIRAGRALCRLGARAVLLKGGHFDGDPVIDRLIAGDDV 195

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHG 255
             F  PRI T++THGTGCTL++A+A    R  +    ++ A+++L +AL  A  L  GH 
Sbjct: 196 VTFAHPRIATRHTHGTGCTLASAIACGLARGLDLRAAIEAAEAFLHAALRAAPGLGRGH- 254

Query: 256 IGPVHHFHA 264
            GP+ H  A
Sbjct: 255 -GPLGHARA 262


>UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=Prevotella
           RepID=D1W4K2_9BACT
          Length = 357

 Score =  148 bits (373), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 84/253 (33%), Positives = 141/253 (55%), Gaps = 7/253 (2%)

Query: 1   MKRINA-LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK+ N  LTI G+D SGGAGIQAD+K  ++LG Y  SVIT++  QNT G+Q  Y I  D 
Sbjct: 1   MKQRNTILTITGSDGSGGAGIQADIKVITSLGGYAVSVITSITMQNTLGIQRFYDIPADI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           VA Q++++  D++    K+GM+     +E V   L + Q   ++ D V+ +  GD L+ P
Sbjct: 61  VAEQVEALVDDIKPSVVKVGMVRNVKTLENVVSILAKRQPLKLIYDPVVTSSQGDLLMPP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             + +++++LLP  SL+     +AA LL++P  +T  +++   R LL MGC AVL+  G 
Sbjct: 121 EMIDSVKTKLLPLCSLVILKQNDAAYLLNSP-LKTHDDIVNGMRKLLNMGCRAVLLHSG- 178

Query: 180 LDDEQSPDWLFTREGEQRFT-APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            DD     W   ++G+     +P +   N HG G  L++A+A       ++ + +    +
Sbjct: 179 -DDHDFIAW--QQDGDIHVEPSPTLWQTNAHGLGSNLTSAIAYFLGETDDFREAISRGNA 235

Query: 239 WLSSALAQADTLE 251
           ++   +++   L+
Sbjct: 236 YIHQQMSEMGELK 248


>UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolobaceae
           RepID=A4YD59_METS5
          Length = 403

 Score =  147 bits (371), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 105/264 (39%), Positives = 147/264 (55%), Gaps = 7/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+R  A+TIAG+D  GGAG+QADLKTF++LG +G SVIT L AQNT  V  V  + P+FV
Sbjct: 2   MQRPIAMTIAGSDSGGGAGVQADLKTFTSLGVFGVSVITGLTAQNTARVTKVLEVPPEFV 61

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q D++  D ++   K GMLA + IV+AV  +L +Y I N+VLD VM++KSG PL++  
Sbjct: 62  ESQFDTIMEDFQVKYAKTGMLASSRIVDAVERKLTQYGI-NLVLDPVMISKSGYPLVTEE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            V  +  RL  +  +ITPN  EA   L     RT  ++      L       V++KGG  
Sbjct: 121 VVRDI-VRLARKSLIITPNKYEAER-LTGFRIRTRDDLRNTALHLYKSLGVNVVVKGGKA 178

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D+      E       I T N HG+G   SA++ A   +  N  D ++EAK  +
Sbjct: 179 IG--GYDFAVVDGDEIELRGELINTDNLHGSGDVFSASITAFLSKGLNLRDALREAKKVV 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHA 264
           S A+    +L +GHG GPV  F +
Sbjct: 237 SEAIKF--SLAIGHGNGPVDPFSS 258


>UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FQ29_NANOT
          Length = 492

 Score =  147 bits (371), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 100/284 (35%), Positives = 149/284 (52%), Gaps = 31/284 (10%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +KR+  L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ I  +FV
Sbjct: 3   LKRV--LVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVIPTEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+ +   DV  D  KIGMLA  +    VAE L+ +++ ++ L         DPLL P 
Sbjct: 61  RKQIRAGLEDVGADGVKIGMLASMETAVMVAEELKAHKVPSITL---------DPLLPPD 111

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           AV  +R  LLP  +++TPN+PEA  LL     D        + +   +++  +G   +L+
Sbjct: 112 AVKAVRENLLPITTVLTPNIPEAVLLLRDSGVDVKEPGNLDDAIALAKNIHQLGPKHILL 171

Query: 176 KGGHLD---DEQSP----------DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL      Q P          D L+         A    +KNTHGTGC+L++A+AA 
Sbjct: 172 KGGHLPLNAQRQKPTSDEDAAIVVDILYDGVEVTLIEANFSRSKNTHGTGCSLASAIAAN 231

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
                     V+EA  ++ + +  +  L  G G GP++HFH+ +
Sbjct: 232 LASEMEMTRAVREACRYVEAGINTSTDL--GKGNGPINHFHSLY 273


>UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=59
           Tax=Bacteria RepID=THID_STRCO
          Length = 269

 Score =  147 bits (370), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 98/242 (40%), Positives = 140/242 (57%), Gaps = 5/242 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  ALG +G SV+TA+ AQN+RGVQ  + +  + V AQ  SV  D+ +   K G
Sbjct: 27  IQADLKTMLALGTHGMSVLTAVTAQNSRGVQGAWELPVEAVRAQYRSVVDDIGVQAVKTG 86

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  ++VE VAE L       VV D V ++K GD LL+ SA+ ++R+RLLP  ++ TPN
Sbjct: 87  MLSSAELVETVAELLAGTDAPAVV-DPVGVSKHGDALLASSALESVRTRLLPVATVATPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L E A L        E ++     ++LA G    L+KGGHL  + + D L     E    
Sbjct: 146 LDEVAQLTGV-RVDDETDLRRAAAAVLAFGPRWALIKGGHLAGD-AVDLLTDGSEEHWLR 203

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           APR+  ++THGTGCTL++A+A    +  +    V+ AK +++ A+       +G GIGPV
Sbjct: 204 APRLDNRHTHGTGCTLASAVACGLAKGQSVPVAVRAAKEYVTGAITAG--FPLGGGIGPV 261

Query: 260 HH 261
            H
Sbjct: 262 DH 263


>UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosphaerula palustris
           E1-9c RepID=B8GHH9_METPE
          Length = 280

 Score =  147 bits (370), Expect = 5e-34,   Method: Compositional matrix adjust.
 Identities = 94/244 (38%), Positives = 134/244 (54%), Gaps = 3/244 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           + + A TIAG+DP+GGAGIQADL TF+A+G +G SVITAL AQ    V S +      VA
Sbjct: 5   QTVCACTIAGSDPTGGAGIQADLSTFAAMGVWGLSVITALTAQTPERVDSTWVQPAPIVA 64

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL  +  +  I   K GML +  +++ + + L       V    V+++ SG  LL+  A
Sbjct: 65  TQLKVLLEEFHIGAFKTGMLGDGSVIDTITDLLPEGVPLVVD--PVLVSSSGHRLLAEEA 122

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  L+ RLLP+ ++ITPNLPE   L       ++ E++  G+ LL +G  AV++KGGH  
Sbjct: 123 IELLKERLLPRATVITPNLPETEVLSGLSPLCSDDEVIRAGKVLLDLGAAAVIIKGGHRA 182

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             ++ D L T       ++ R      HGTGC  SAAL AL  R        QEAK  +S
Sbjct: 183 GARATDLLITASTVIPLSSFR-RPYPVHGTGCCFSAALTALLARGYPLPTAAQEAKCLIS 241

Query: 242 SALA 245
            A++
Sbjct: 242 RAVS 245


>UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta proteobacterium MLMS-1
           RepID=Q1NV70_9DELT
          Length = 288

 Score =  145 bits (365), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 107/281 (38%), Positives = 149/281 (53%), Gaps = 33/281 (11%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+DP+GGAGIQADLKT +ALG YG + IT +  QN++GV+    +E   V  Q+ +
Sbjct: 10  LSIAGSDPAGGAGIQADLKTCTALGVYGAAAITCVTVQNSQGVRYFEPLEQQLVYDQIRA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+ I   KIGML    + +AVA  L  +    +V D V+ A  G  LL  +A+  L 
Sbjct: 70  VLVDLPISHIKIGMLGSAQVADAVAAALHDF-TGVIVYDPVLKAGDGHTLLPATALQRLA 128

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG--------------- 171
           + LL ++++ITPNLPE A L      R   +   Q  SL A G G               
Sbjct: 129 ADLLSKITVITPNLPELATL-----DRLLPQPPGQAPSLPA-GIGADSPLTAAARLLQRF 182

Query: 172 ----AVLMKGGHLDDE--QSPDWLFTR-EGEQ----RFTAPRIMTKNTHGTGCTLSAALA 220
               AV + GGH + E  +  DWL TR EG+Q    R   PR+ + N HGTGCT + ALA
Sbjct: 183 PRLQAVALTGGHAEPEYDELTDWLLTRGEGQQLKVTRVEHPRLKSGNLHGTGCTFATALA 242

Query: 221 ALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           A      ++   ++ A  + S+A+     L +G G GP+ H
Sbjct: 243 ACHLLSGDYQRAMRRAVDFTSAAIKAGAGLSMGGGNGPLAH 283


>UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=15
           Tax=Actinomycetales RepID=THID_MYCLE
          Length = 279

 Score =  144 bits (364), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 90/242 (37%), Positives = 133/242 (54%), Gaps = 7/242 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD++T + LG + C+ +TA+  QNT GV+  + I  + VA+Q+ +V +D+ I + K G
Sbjct: 30  IQADMRTMTVLGVHACTAVTAVTIQNTLGVEGFHEIPAEIVASQIKAVVTDIGIQSAKTG 89

Query: 80  MLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           MLA + I+ AVAE   R ++   +V+D V  +  GDPLL+  A+ +LR RL P  +++TP
Sbjct: 90  MLASSSIIAAVAETWLRLELTTPLVVDPVCASMHGDPLLTGEAMDSLRDRLFPLATVVTP 149

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQSPDWLFTREGE-- 195
           NL E   L+      TE +      +L A+G    L+KGGHL   ++S D L+       
Sbjct: 150 NLDEVRLLVGIDVVDTESQR-AAAMALHALGPQWALVKGGHLRSSDRSCDLLYGGSSAGV 208

Query: 196 --QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVG 253
               F APR+ T N HG G TL+AA++          D V   K W++  L  A  L  G
Sbjct: 209 AFHEFDAPRVQTGNDHGGGDTLAAAVSCALAHGYTVPDAVGFGKRWVTECLRDAYPLGRG 268

Query: 254 HG 255
           HG
Sbjct: 269 HG 270


>UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold_16 n=1
           Tax=Sordaria macrospora RepID=D1ZB20_SORMA
          Length = 536

 Score =  144 bits (364), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 105/290 (36%), Positives = 164/290 (56%), Gaps = 34/290 (11%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT+GV  ++ +  DF+  Q+D+
Sbjct: 15  LVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTKGVYGIHEVPVDFLRKQIDA 74

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  DV +D  K GMLA T  +EAVA+ +   +++ +V+D VM+A +G  LL  SA   LR
Sbjct: 75  VVEDVGVDVVKTGMLASTSTIEAVAQAIHDNKLKTLVVDPVMIATTGAELLPNSASRALR 134

Query: 127 SRLLPQVSLITPNLPEAAA-LLDAPH----ARTEQEMLEQGRSLLAMGCGAVLMKGGH-- 179
            +LLP  +++TPN+PEA   LL+A H     ++  ++ E    +  +G   VL+KGGH  
Sbjct: 135 EKLLPLATILTPNVPEANTLLLEAGHDKHLVQSVADLEEIALKVQKLGSKWVLVKGGHSP 194

Query: 180 ---------LDDEQS--------PDWLFTR---EGEQRFTAPRI-----MTKNTHGTGCT 214
                     +DE+         P    T+   EGE++    +I      ++NTHGTGC+
Sbjct: 195 FRRDGTEAKTEDEKEIVVNVLVGPAAEGTKRDVEGEEKLQVVKIEMPYQRSRNTHGTGCS 254

Query: 215 LSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
           L++A+A+   +  +    V+    ++ +A+  A  L  G G GP++HFH+
Sbjct: 255 LASAIASNLAKGMDMVSAVKAGIRYVDAAIRTAPGL--GQGNGPLNHFHS 302


>UniRef50_A1ESK8 Phosphomethylpyrimidine kinase (Fragment) n=1 Tax=Vibrio cholerae
           V52 RepID=A1ESK8_VIBCH
          Length = 189

 Score =  144 bits (363), Expect = 3e-33,   Method: Compositional matrix adjust.
 Identities = 77/175 (44%), Positives = 111/175 (63%), Gaps = 1/175 (0%)

Query: 90  VAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDA 149
           VA++L++YQ + +VLD VM++ SG  LL+  AV TL+  LLP  +LITPNLPEAA L+  
Sbjct: 3   VAKKLRQYQPKWIVLDPVMISTSGHHLLAAEAVETLKRELLPLANLITPNLPEAAVLVGM 62

Query: 150 PHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR-FTAPRIMTKNT 208
                +Q   +   +L  +   AVL+KGGH   + + D L  + G+ R F APRI TKNT
Sbjct: 63  TQQEWQQNPQQGVTALSQLNTPAVLLKGGHDHQQANSDDLLIQSGDSRYFCAPRIATKNT 122

Query: 209 HGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFH 263
           HGTGC+LS+A+A+   +     + V +AK ++  A+  AD L +G G GP+HHF+
Sbjct: 123 HGTGCSLSSAIASYLAQGAELVEAVDKAKQYIHQAIVHADQLRIGRGYGPIHHFY 177


>UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax=Perkinsus marinus
           ATCC 50983 RepID=C5LCI6_9ALVE
          Length = 504

 Score =  143 bits (361), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 92/258 (35%), Positives = 139/258 (53%), Gaps = 17/258 (6%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           QADLKT  ALG Y  S +T++ AQNT+GVQ +  +  D  AAQ++SV SD  +   K+G+
Sbjct: 248 QADLKTLEALGVYSTSALTSITAQNTKGVQQIQVVNEDIFAAQMNSVTSDFEVSVVKLGL 307

Query: 81  LAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL----SPSAVATLRSRLLPQVSLI 136
           +     +E V E+L    +   V+D V++A SGD L+    +   +A  + R+ P+ ++I
Sbjct: 308 VPTARQLEIVGEKLAELPM---VVDPVLVATSGDDLVAQKNAEDVLAMYKERIFPRATII 364

Query: 137 TPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP----DWLFTR 192
           TPN+ EA  +L         E     ++L   G   VL+KGGH  DE  P    D L+ R
Sbjct: 365 TPNVVEAERILGRKEISGVYEARAAAQALAQYGSKYVLLKGGH--DETDPKACRDVLYDR 422

Query: 193 EGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTL 250
           E ++   FT  RI T NTHGTGCTL++A++A   R       V+ A  +L   + ++  +
Sbjct: 423 EKDEFYEFTNRRIATINTHGTGCTLASAISAFMARGYPVPVAVERAIGYLHEVIVRSCGV 482

Query: 251 EVGHGIGP--VHHFHAWW 266
            +G G     VH  ++ W
Sbjct: 483 PLGQGTNRPLVHSANSVW 500


>UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), ThiD n=2
           Tax=Methanobrevibacter smithii RepID=A5UJW6_METS3
          Length = 246

 Score =  143 bits (361), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 84/234 (35%), Positives = 127/234 (54%), Gaps = 9/234 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           ++IAG DPSGGAGI AD+KTF ALG YG  ++TAL AQN + + S+  IE D+V  Q+D+
Sbjct: 4   MSIAGVDPSGGAGILADIKTFQALGVYGTGIVTALTAQNPQMMYSLKAIETDYVEEQIDA 63

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V     ++  K GML   DI++ V+++++ Y ++ VV D VM+A SG  L        L 
Sbjct: 64  VLDSYNVEYIKTGMLYSKDIIKTVSKKIREYNLKAVV-DPVMVATSGGELAKDDLSQNLL 122

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP+  L TPN+ EA  L     A  ++E  E     L   C  ++  GGHL+     
Sbjct: 123 KYLLPKAILTTPNVSEAEKLTGIKIA--DEEKAEIACEKLGKICNNIIT-GGHLNGTN-- 177

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             +   +G+   F    + T N HG+GC  SAA+ +   +  +   ++ +A  +
Sbjct: 178 --ITCIDGKISTFKQELLKTDNVHGSGCNFSAAIVSYLSQKNDLKTSILKASEY 229


>UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium Ellin514
           RepID=B9XCM9_9BACT
          Length = 264

 Score =  143 bits (361), Expect = 6e-33,   Method: Compositional matrix adjust.
 Identities = 100/246 (40%), Positives = 147/246 (59%), Gaps = 6/246 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLKTF+ALG +G S IT + AQN + +  +    P  V  Q++
Sbjct: 9   ALTIAGSDSGGGAGIQADLKTFAALGVHGTSAITCITAQNPKRLLGIEACSPGIVRQQME 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +VF ++     K GML   +I+++VA   +  +   +V+D VM++ SG  LL P+A+  L
Sbjct: 69  AVFEELPPGAAKTGMLYSEEIIKSVAGFFKSKRQTPLVVDPVMISTSGKRLLKPTAMRAL 128

Query: 126 RSRLLPQVSLITPNLPEAAALL-DAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDD- 182
           + +LLP  +L+TPNL EA  LL  AP   + ++M    R L    GC A LMKGGHL   
Sbjct: 129 QEKLLPLATLVTPNLDEANVLLGKAPD--SIEDMRGAARELHKRFGC-AWLMKGGHLKGA 185

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +++ D  F  + E   T+  +   +THGTGCT SAA+ A        ++ V  AK ++S 
Sbjct: 186 KEAADVFFDGKEELLLTSRFVKGVSTHGTGCTYSAAITAYLALGLELSEAVTMAKHYISE 245

Query: 243 ALAQAD 248
           ++A++D
Sbjct: 246 SIAKSD 251


>UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanocaldococcus infernus
           ME RepID=C5U665_9EURY
          Length = 442

 Score =  143 bits (360), Expect = 6e-33,   Method: Compositional matrix adjust.
 Identities = 87/256 (33%), Positives = 141/256 (55%), Gaps = 8/256 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D   GAGI+ADLKTF + G YG   ITA+ AQNT  ++ +  ++   V  Q+
Sbjct: 9   KALTIAGSDSGSGAGIEADLKTFCSFGVYGLVAITAITAQNTYEIREIRELDAKIVREQI 68

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D  +D  K GML   +I++ V + ++ YQ   +V+D VML+K+   LL   A+  
Sbjct: 69  IAVAEDFGVDAAKTGMLYSGEIIKEVRKVVKDYQFP-LVVDPVMLSKTNTLLLKEDAIEK 127

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L + L    +LITPN+ E A  L +       + +E  ++L       +L+KGGHL  E 
Sbjct: 128 LEN-LFKISTLITPNINE-AEFLSSKKITNLDDAIEVAKTLFEKYKTNILIKGGHLKGE- 184

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D L+   GE +    + ++  THGTGC+ SAA+ A   +     + +++AK ++  ++
Sbjct: 185 AIDILYN--GELKLFKSQRVSGCTHGTGCSFSAAITACLAKGEELEEAIKKAKDFIIKSI 242

Query: 245 AQADTLEVGHGIGPVH 260
              ++  +G    PV+
Sbjct: 243 --RNSYRIGKKYCPVN 256


>UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomycetales
           RepID=C7QH05_CATAD
          Length = 290

 Score =  143 bits (360), Expect = 7e-33,   Method: Compositional matrix adjust.
 Identities = 99/249 (39%), Positives = 140/249 (56%), Gaps = 6/249 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  A G +G SV+TA+ AQN+ GVQ  + +  + V  Q  SV  D+ +D  K G
Sbjct: 37  IQADLKTMLAHGVHGMSVLTAVTAQNSVGVQDFWALPIEAVERQFRSVVDDIGVDAVKTG 96

Query: 80  MLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           MLA  ++   VA  +        VV+D V ++K GD LL+P A+  LR  LLP+ +++TP
Sbjct: 97  MLASPELTSTVARLIGTLDPSVPVVVDPVSVSKHGDALLAPEALDALRGELLPRATVVTP 156

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE-QSPDWLFTREG-EQ 196
           NL E   L+       E EM+   R+L  +G   VL+KGGHL D  +S D L   +G E 
Sbjct: 157 NLDE-VRLITGLDVVAEPEMVAAARALADLGPRWVLVKGGHLSDHPESVDLLVGPDGAEH 215

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
              APR   ++THGTGCTL++A+A+      +    V+ AK +++  +A      +G GI
Sbjct: 216 WLRAPRHDNRHTHGTGCTLASAIASRLALGDDVPTAVRAAKEYVTGGIAAG--FPLGAGI 273

Query: 257 GPVHHFHAW 265
           GPV H   W
Sbjct: 274 GPVDHGWRW 282


>UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F301_ACIC5
          Length = 303

 Score =  142 bits (358), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 104/260 (40%), Positives = 130/260 (50%), Gaps = 8/260 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG DPS GAGI ADLK F+A   YG S +TAL  Q+T+GV     ++   +   L  
Sbjct: 38  LTIAGFDPSSGAGITADLKVFAACQLYGVSAVTALTVQSTQGVLRSQPVDSALLGETLRC 97

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI--QNVVLDTVMLAKSGDPLLSPSAVAT 124
           +  D+ I   KIGML   + V  VA  L+ +    + VVLD V+ + SG  LL  S    
Sbjct: 98  LQQDLPIAGVKIGMLGSGENVATVAAWLRDFSFPRERVVLDPVLRSSSGRDLLDASGQTL 157

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           LR +LLPQ   ITPNL E AAL   P    EQ            G   V   GGHLD   
Sbjct: 158 LREQLLPQTGWITPNLDELAALTGLPVTNREQMRAAAEALAATAGL-RVAATGGHLDPPD 216

Query: 185 SPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
             D L T EGE Q F    + T+ THGTGC  S+AL        +    V  AK ++  A
Sbjct: 217 --DLLATPEGEAQWFPGRHLATRATHGTGCAFSSALLCRLVLGDSAEAAVAAAKQYVKEA 274

Query: 244 LAQADTLEVGHGIGPVHHFH 263
           +  A    +G G GP+HH +
Sbjct: 275 MEAA--YPIGRGRGPMHHLY 292


>UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41D57
          Length = 266

 Score =  141 bits (356), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 82/218 (37%), Positives = 126/218 (57%), Gaps = 11/218 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DPSGGAGI  D+KT +A G + CSVITAL AQN + V SV  IE  ++  Q+DS
Sbjct: 4   LSIAGFDPSGGAGISTDMKTMAAHGVHPCSVITALTAQNPKKVFSVQAIETSYIRQQIDS 63

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +F +  I  +K G+L   +I++ V+++++   ++ +V+D VM+A SG  L       +L+
Sbjct: 64  IFDEYPIKYSKTGLLYSKEIIQLVSKKVEELNLR-IVVDPVMVASSGGQLAKKEMANSLK 122

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMG-CGAVLMKGGHLDDEQS 185
             LL    L+TPN+ EA  L        E    +   +   +G C  V++ GGHLD    
Sbjct: 123 KYLLKNALLVTPNVKEAEELSGISIKSIE----DAKEAAYKIGECCNVMITGGHLD---G 175

Query: 186 PDWLFTREGEQRFTAPR--IMTKNTHGTGCTLSAALAA 221
            + ++ ++ ++     +  I T N HGTGC+LSAA+ A
Sbjct: 176 NNVIYNKQKDELSILKQNLIKTDNLHGTGCSLSAAICA 213


>UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospira
           RepID=Q04W62_LEPBJ
          Length = 270

 Score =  141 bits (355), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 92/246 (37%), Positives = 141/246 (57%), Gaps = 6/246 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKTF+AL  +G S IT L +QN  G+  +  +  DF+  Q+ +
Sbjct: 10  LTIAGSDSGGGAGIQADLKTFTALDTFGTSAITCLTSQNPSGITEILEVNADFLEKQILA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEA----VAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           V     + + K GML  T I+E     ++ R    +  ++V+D VM++  G  LL  SA+
Sbjct: 70  VLDYFPVKSIKTGMLFSTAIIEKTSYLLSNRKNTEKNFSLVIDPVMVSTRGSKLLQESAI 129

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L ++L+P   LITPNL EA  L     +++ +EM +  +++       VL+KGGHL +
Sbjct: 130 DILLTKLIPLADLITPNLDEAEILTGKKISKS-REMPDFAKAIFEKFKVPVLLKGGHLQN 188

Query: 183 EQ-SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           E+ + D LF  +   +F  P +     HGTGCT S+A+ +   R    A+ +Q AK +L 
Sbjct: 189 EEVALDILFDGKSISKFEKPFVNGFYPHGTGCTYSSAITSYLARGEKLAEAIQLAKEYLH 248

Query: 242 SALAQA 247
           +A+ Q+
Sbjct: 249 AAIEQS 254


>UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospirillum
           ferrodiazotrophum RepID=C6HXY3_9BACT
          Length = 270

 Score =  141 bits (355), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 97/245 (39%), Positives = 134/245 (54%), Gaps = 5/245 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL++AG DPSGGAG+  DL+ FSALG  G  V T L  QN +GV     + P+ ++A L+
Sbjct: 5   ALSVAGLDPSGGAGLYQDLRVFSALGIRGQGVPTVLTVQNLQGVGRTEPLSPELLSAMLE 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSPSAVAT 124
           +V  +      KIG++A + +VE +A+ L       V +LD V L  +G  +L+P A   
Sbjct: 65  AVVGEGPPRAVKIGLMASS-LVEELADFLDGLPKDVVRILDPVFLFGTGGSVLTPPAYRD 123

Query: 125 LRSRLLPQVSLITPNLPEAAAL-LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           L   L P+V L+TPNLPEA  L  + P +R E  +L   R     G  AVL+KGGH + E
Sbjct: 124 LARSLFPRVDLVTPNLPEALELGGEIPGSRPEDLVLMARRLHDQYGVRAVLLKGGHRNGE 183

Query: 184 QS-PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR-HTNWADTVQEAKSWLS 241
           +   D  +T  GE+ F+ P       HG GCTLS+ +AAL  R  ++  D V  A     
Sbjct: 184 EPRTDLFWTPSGERFFSHPFRRLPGVHGGGCTLSSLVAALLVRGESSLIDAVARALELYQ 243

Query: 242 SALAQ 246
             LAQ
Sbjct: 244 MLLAQ 248


>UniRef50_D0LJB6 Phosphomethylpyrimidine kinase n=1 Tax=Haliangium ochraceum DSM
           14365 RepID=D0LJB6_HALO1
          Length = 292

 Score =  140 bits (354), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 101/210 (48%), Positives = 132/210 (62%), Gaps = 7/210 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG+D  GGAGIQADL+TFS LG +G + ITA+ AQN  GVQ+V  I  + VAAQ++
Sbjct: 11  ALSIAGSDSGGGAGIQADLRTFSRLGVFGTTAITAVTAQNLDGVQAVTGISVELVAAQME 70

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +VF+   +   K GML   ++VE VA  +    +  VV D VM+A SG  LL   AVA  
Sbjct: 71  AVFTGFEVGALKTGMLWSAELVERVAAMIDARGVAAVV-DPVMVATSGARLLQEDAVARY 129

Query: 126 RSRLLPQVSLITPNLPEAAALLD-APHARTEQEMLEQGRSL-LAMGCGAVLMKGGHLDDE 183
           R RL+P  +L+TPNL EAA LL+  P A  E + +   R+L    GC AVL+KGGHL+ +
Sbjct: 130 RERLIPGCTLVTPNLDEAAVLLERGPIAAAELDQV--ARALGQRFGC-AVLLKGGHLEGD 186

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGC 213
              D L+ R G  R+   RI   NTHG+GC
Sbjct: 187 -PVDVLWHRGGWTRWRHERIRGVNTHGSGC 215


>UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas mobilis
           RepID=C8WAW8_ZYMMN
          Length = 283

 Score =  140 bits (352), Expect = 5e-32,   Method: Compositional matrix adjust.
 Identities = 97/267 (36%), Positives = 150/267 (56%), Gaps = 11/267 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQAD+++ + LG +  + IT+L AQNT+GV ++  + P  V AQ+D+
Sbjct: 17  LTIAGSDSGGGAGIQADIRSITMLGGHALTAITSLTAQNTQGVSAIDVVSPQMVIAQIDA 76

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V +D+ +   KIGM+   ++  AVA+ L++     VVLD VM+A SG  L     +    
Sbjct: 77  VVTDIGVSAIKIGMIGSGEVAVAVADYLEKIPNIPVVLDPVMVATSGSALADKKTIQAF- 135

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            RL+ +  LITPN+PE   +L      ++  ++   + L       +L KGGH + E   
Sbjct: 136 DRLMYRADLITPNIPE-LEVLTKQDCSSDASLIAAAQQLARHYDCPILAKGGHGEGEILT 194

Query: 187 DWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           D L   +GE   +   RI T+NTHGTGC+LS+A+A    +     + +  A+ ++ +AL 
Sbjct: 195 DRLVMPDGEVISWQDSRIPTQNTHGTGCSLSSAIATSLGQGLPLKEAITRARQYIRTALE 254

Query: 246 QADTLEVGHGIGPVHH------FHAWW 266
           +A +L  GH  GP+ H      F  W+
Sbjct: 255 KAPSLGKGH--GPIGHTLGISAFDRWF 279


>UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZRE6_9GAMM
          Length = 262

 Score =  140 bits (352), Expect = 6e-32,   Method: Compositional matrix adjust.
 Identities = 96/245 (39%), Positives = 140/245 (57%), Gaps = 10/245 (4%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DP GGAG+QADL TF+ LG +G + +TA+  Q+TR V     + P+ + AQ++
Sbjct: 7   ALTIAGSDPGGGAGLQADLTTFTRLGVHGATAVTAITVQDTRNVVDFTVLPPEQLRAQIE 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
              +D+ +   KI ML   + V  ++  L  +    VVLD VM+A  G  L + + V   
Sbjct: 67  VTLADLEVAAIKISMLGSVENVTVISALLGAHPHIPVVLDPVMVAGGGGALATEAVVDAT 126

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLP+ +LITPN PEAA L     AR+E +  + G  L  +G   VL+ GGH   EQ 
Sbjct: 127 REALLPRATLITPNGPEAARL-----ARSE-DPAQWGHQLRQLGARNVLVTGGHEGTEQD 180

Query: 186 P--DWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           P  + L+  +   R F  PR      HG+GCTL+AA+AA   R  +    V EA+++++ 
Sbjct: 181 PIINRLYREDDHVRPFELPR-HPAGFHGSGCTLAAAIAAFLARGRDIEPAVIEAQAFMND 239

Query: 243 ALAQA 247
           A+A+ 
Sbjct: 240 AIARG 244


>UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C31AB2
          Length = 284

 Score =  140 bits (352), Expect = 6e-32,   Method: Compositional matrix adjust.
 Identities = 99/244 (40%), Positives = 134/244 (54%), Gaps = 15/244 (6%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLK F+A G +G + ITAL AQNT GV +V  I P+ + AQ+ +V  D+ ID  KIG
Sbjct: 32  IQADLKVFAACGVHGMTAITALTAQNTVGVDAVAPIAPEMIVAQVRAVARDIGIDAVKIG 91

Query: 80  MLAETDIVEAVAERL-QRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML     +EAV   L +  +   +VLD VM+++SG PLL P A   L   LLP+V++ TP
Sbjct: 92  MLGTVVTIEAVVAALGELAEGTPIVLDPVMVSESGAPLLEPEARDALIELLLPRVTVATP 151

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRF 198
           NLPEA  +     A ++ +  E  R++ A+G   V++ GGH D  ++ D +F  E     
Sbjct: 152 NLPEARVI-----AGSDDDAPELARAIHALGPRHVVVTGGHRD--KATDVMFDGETTIEI 204

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA--DTL-EVGHG 255
              R      HG+GCT S+ALAA    H        +A        AQA  D L E+G G
Sbjct: 205 PGERHPDGAAHGSGCTHSSALAA----HLALGFAPVDAARAAKVIAAQAVHDGLREIGRG 260

Query: 256 IGPV 259
            GPV
Sbjct: 261 PGPV 264


>UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1INF7_ACIBL
          Length = 254

 Score =  139 bits (351), Expect = 8e-32,   Method: Compositional matrix adjust.
 Identities = 91/256 (35%), Positives = 133/256 (51%), Gaps = 7/256 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DPS GAGI AD+KT +A   Y  + ITA+  Q T  V +V  +  + V   L  
Sbjct: 5   LSIAGYDPSSGAGITADVKTAAAHECYAITCITAVTVQTTEKVFAVEPLRAEIVRDTLYE 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D+     +IGML   ++ E VA+ L+  +++NVVLD V+ + SG  L+       +R
Sbjct: 65  LVRDMPPAAVRIGMLGSGEVAEVVADFLETTRLRNVVLDPVLRSTSGAALIDERGEQVIR 124

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           +RLL  V + TPN  EA  L     A  E       R L   GC AV++ GG  +D  S 
Sbjct: 125 ARLLKAVDVCTPNEAEARVL-----AECEASPEGLARELHRKGCPAVVITGGERED--SG 177

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D L   + ++   A +I ++ THGTGC  + A+A          + V EAK ++  A+  
Sbjct: 178 DLLSFGDQQEWLRAEKIRSRATHGTGCAFATAIACNLALGRQLREAVVEAKFYVRRAITL 237

Query: 247 ADTLEVGHGIGPVHHF 262
                +GHG GP++HF
Sbjct: 238 GSDEPLGHGRGPMNHF 253


>UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phosphate
           pyrophosphorylase fused protein ThiE n=4 Tax=Legionella
           pneumophila RepID=Q5ZV72_LEGPH
          Length = 495

 Score =  139 bits (349), Expect = 1e-31,   Method: Compositional matrix adjust.
 Identities = 93/264 (35%), Positives = 141/264 (53%), Gaps = 7/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+    TIAG D SG AG+ AD++TFS L    CSVITA+ AQN   + +V  I  D V
Sbjct: 8   MKKPIVWTIAGVDSSGLAGVHADMETFSRLNVRACSVITAVTAQNAHSIIAVEEISRDQV 67

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AAQ  ++  +++ D  KIGML  T I E +A  L+ Y+   VVLD ++ + SG  L  P 
Sbjct: 68  AAQCRALELNLKPDAIKIGMLCSTPICEEIAYFLKGYE-GFVVLDPIITSSSGTNLFFPD 126

Query: 121 AVATLRS--RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
                 +  +L P +++ITPN  EA  +L+     + Q+++     LL++G   VL+KGG
Sbjct: 127 LQQHKNNLIQLFPYITIITPNRIEAEIILNRS-IYSYQDIINAASDLLSLGAKQVLLKGG 185

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTK-NTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H+ D       +T   E  + A R   + N  GTGC LS+AL A      +  D +  AK
Sbjct: 186 HVKDNSFSQDYWTDGKESFWIANRRFPETNYRGTGCVLSSALTACLALGYSIKDAIVIAK 245

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
            +++  + Q  ++E+      ++H
Sbjct: 246 MYVNRGIRQ--SIEIDKDASQLYH 267


>UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NFK8_METST
          Length = 259

 Score =  138 bits (348), Expect = 1e-31,   Method: Compositional matrix adjust.
 Identities = 80/244 (32%), Positives = 134/244 (54%), Gaps = 7/244 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +  ++TIAG DPSGGAGI AD KTF A G Y   V+TA+ AQN   V  +  ++ D +
Sbjct: 6   MNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLI 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +++D + S   I   K GML   DI++ V+ +++ Y ++ VV D VM+++SG  L   S
Sbjct: 66  ESEIDEILSVYPIRYIKTGMLYSGDIIKLVSRKIKEYDLRAVV-DPVMVSESGGDLTGNS 124

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  +   L+    +ITPN+ EA  L +     +E++M+     L      +V++ GGH+
Sbjct: 125 FIEYMNKYLVKNSFIITPNIHEAEKLSNKT-ITSEEDMISVAEKLSKD--NSVVITGGHM 181

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              Q  D L+  +   R     I + NTHGTGCT S+A+ +      N  ++ +++  ++
Sbjct: 182 ---QGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFI 238

Query: 241 SSAL 244
            +++
Sbjct: 239 RNSI 242


>UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=17
           Tax=Actinomycetales RepID=THID_MYCBO
          Length = 265

 Score =  138 bits (348), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 91/238 (38%), Positives = 135/238 (56%), Gaps = 3/238 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD++T + LG + C  +TA+  QNT GV+ ++ +  D VA Q+++V +D+ +   K G
Sbjct: 20  IQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTG 79

Query: 80  MLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           MLA + IV  VA   +R ++   +V+D V  +  GDPLL+PSA+ +LR +L P  +L+TP
Sbjct: 80  MLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTP 139

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQSPDWLFTREGEQR 197
           NL EA  L+D      E +     ++L A+G   VL+KGGHL   + S D L+      +
Sbjct: 140 NLDEARLLVDIEVVDAESQR-AAAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQ 198

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHG 255
           F A R+ T + HG G TL+ A+AA         D V   K W++  L  A  L  GHG
Sbjct: 199 FDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHG 256


>UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7M9W8_BRAFD
          Length = 291

 Score =  138 bits (347), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 88/217 (40%), Positives = 124/217 (57%), Gaps = 2/217 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIA ++  G  G+QADLKTF+ALGAYG S ++ +       V   Y +  + V  Q+D+
Sbjct: 7   LTIAASESDGAGGLQADLKTFTALGAYGASAVSMIATITAHEVHGTYPLPAEVVRGQIDA 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERL--QRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           V  D+R+D TKIG L    +V+AVA  +   R ++  +VLD VM++  G PL+S      
Sbjct: 67  VAGDLRLDATKIGALGSAAVVDAVAAAVRAHRDRLGRIVLDPVMVSAHGAPLISAEGAKA 126

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           LR +LLP V ++TP + EAA LL  P A + +E+ EQ  +L A G  +VL+ G  L+ E 
Sbjct: 127 LREQLLPLVDVLTPTMAEAAQLLGRPLATSIEEIREQALALQAAGPRSVLVTGRLLEGED 186

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
             D L    G     A R+  +   G G TLSAA+AA
Sbjct: 187 VVDVLVHEGGTDLLRAERVPGRRVRGAGATLSAAIAA 223


>UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidine phosphate
           kinases n=1 Tax=Pichia pastoris GS115 RepID=C4QXJ6_PICPG
          Length = 557

 Score =  137 bits (346), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 96/291 (32%), Positives = 158/291 (54%), Gaps = 39/291 (13%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LT+AG+DPSGGAGI+AD+KT SA    G S I AL AQNT GV++V + +  F+   L 
Sbjct: 31  VLTLAGSDPSGGAGIEADIKTISAFHCLGLSAINALTAQNTTGVKNVLQTDERFLTQLLQ 90

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSPSAVAT 124
           ++F D+RID  K GM+  +  V+ +   L ++   + +V+D V+ + SG  L     + +
Sbjct: 91  ALFEDMRIDAIKTGMMT-SKAVKLLPFYLDKFHRGKPLVIDPVLSSTSGFDLGKLDVLKS 149

Query: 125 LRSRLLPQVSLITPNLPEAAALL-----------DAP-----HARTEQEMLEQGRSLLAM 168
             S    + ++ITPN  EA  ++           D P       +   + L+Q      +
Sbjct: 150 SISTFFAKATVITPNFIEAKKIMCAIQGISFDTFDLPVNGINDLKALAKFLQQN-----I 204

Query: 169 GCGAVLMKGGHL--DDEQSP------------DWLFTREGE-QRFTAPRIMTKNTHGTGC 213
           GC +VL+KGGH+  D++  P            + L+ + G+   F +    +K THGTGC
Sbjct: 205 GCQSVLVKGGHIPWDEDFRPSDITGKPPRYLTEVLYEQSGDVTVFKSDFNRSKFTHGTGC 264

Query: 214 TLSAALAALRPRHTNWADTVQEAKSWLSSALAQAD-TLEVGHGIGPVHHFH 263
           TL++A+AA   R  + +++VQ + S++ +++  AD +L  G G GP++H +
Sbjct: 265 TLASAMAANLARGLSISESVQLSISFVQNSIKYADKSLGSGTGYGPMNHLY 315


>UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-phosphate
           pyrophosphorylase n=3 Tax=Alteromonadales
           RepID=Q3IFN5_PSEHT
          Length = 508

 Score =  137 bits (345), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 85/251 (33%), Positives = 136/251 (54%), Gaps = 14/251 (5%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+K   + G +GC+ ITAL AQN+ GV+++  +  D + +QL ++  D++    KIG
Sbjct: 19  IQADIKAMQSFGVHGCTAITALTAQNSLGVEAINAVSTDIIESQLLALEKDMKAKVIKIG 78

Query: 80  MLAETDIVEAVAERLQRYQIQ-----NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           MLA    ++ ++E +  Y+ +      +V D V +A SGD L     V+ ++  LLP V 
Sbjct: 79  MLANVQQIQLISEHISHYKAKWPVPPVIVYDPVAIASSGDLLTEEDTVSAIKECLLPLVD 138

Query: 135 LITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQSPDWL--- 189
           +ITPN  E   LL   +      + E    LL+ G  AV++KGGH D       D+    
Sbjct: 139 VITPNTHE-TQLLTGVYLIGPAAIKEAANKLLSWGAKAVVIKGGHWDYPSGYCIDYCINN 197

Query: 190 FTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQAD 248
           FT++GE+ +    +I T + HGTGC++++ +AA   +     D    AK++++  L  A 
Sbjct: 198 FTQKGEEYWLGNEKIQTPHNHGTGCSMASVIAACLAKDYPLKDAFILAKAYINQGLKVA- 256

Query: 249 TLEVGHGIGPV 259
            +  G GIGPV
Sbjct: 257 -VRYGEGIGPV 266


>UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma phagocytophilum HZ
           RepID=Q2GJ96_ANAPZ
          Length = 265

 Score =  137 bits (344), Expect = 5e-31,   Method: Compositional matrix adjust.
 Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 6/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M + N L+IAG+D  GGAGIQAD+KT + LG Y  + ITA+ AQNT+ V+ V+ + P+ V
Sbjct: 1   MYKGNVLSIAGSDSGGGAGIQADIKTITMLGCYAATCITAITAQNTQEVRGVWELAPEVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL++V  D+++D  KIGML    ++  VAE L   +I  V+LD VM++ SG  L  P 
Sbjct: 61  KGQLEAVLDDLKVDAIKIGMLP-VGLIGVVAESLP-CEIP-VILDPVMVSTSGFELTDPM 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGH 179
                   L    +L+TPN+ E  AL    + RT +EM+  G  ++  +G  AVL+KG  
Sbjct: 118 GYTESIRPLAQNAALVTPNIKETEALSGMKNIRTREEMVTAGNKIIQFLGIKAVLVKGCI 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            ++E+  + +   +G+  F          HGTGCTL++A+A    R  +  ++ + A  +
Sbjct: 178 WEEEEFVESVLIYDGKTVFFRNERAPGELHGTGCTLTSAIACFIARGLSLEESTRLAFDY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +S  +  A    VG G+ P+ H +
Sbjct: 238 VSCTIRNAPI--VGQGLRPLFHNY 259


>UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter concisus 13826
           RepID=A7ZEN6_CAMC1
          Length = 254

 Score =  136 bits (343), Expect = 6e-31,   Method: Compositional matrix adjust.
 Identities = 86/256 (33%), Positives = 134/256 (52%), Gaps = 29/256 (11%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L +AG+D  GGAG+QAD+K+  A   +  SVITA+ AQNT GV SV  +  + V AQ 
Sbjct: 9   NVLIVAGSDSVGGAGVQADIKSCEAFSCFSASVITAVTAQNTNGVSSVLAMPANMVKAQF 68

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN--VVLDTVMLAKSGDPLLSPSAV 122
           + V +++ ID  K+GML   +I+  V+  L+  + +N  VV+D V +AKSG  LL   A+
Sbjct: 69  EMVLAELDIDAVKVGMLFNEEIIAVVSAFLKELRAKNVPVVIDPVCVAKSGAKLLEDGAI 128

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L+  LL   S+ TPN+ EA  L               G     + C  VL +     D
Sbjct: 129 EALK-ELLNLASVATPNVDEARIL---------------GIDFANLPCDMVLKRTKV--D 170

Query: 183 EQSPDWLFTREGE-----QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           E   D L+ + G+     +    PR+M    HG GC+ S++LAA+  + ++    ++ AK
Sbjct: 171 EICEDTLYLKNGDAMKFSEELFEPRVM----HGAGCSFSSSLAAILAQQSDLVSAIKMAK 226

Query: 238 SWLSSALAQADTLEVG 253
            ++++ +  A   + G
Sbjct: 227 KFVANGIKNAHKSKFG 242


>UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivallis vadensis ATCC
           BAA-548 RepID=D1N338_9BACT
          Length = 281

 Score =  136 bits (343), Expect = 6e-31,   Method: Compositional matrix adjust.
 Identities = 96/244 (39%), Positives = 142/244 (58%), Gaps = 4/244 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+T+AG+D  GGAGI+ADL+TF+A G YGC+ +TA+ +QN   V+ +  I  + V  Q++
Sbjct: 14  AMTVAGSDSGGGAGIEADLRTFNAYGVYGCAALTAVTSQNPAEVRRIDAIPAEGVRCQIE 73

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V   + +   K GML    IVEAVAE +++ ++  +V D VM++ SG  LL   AVA +
Sbjct: 74  TVLDRIPVRAVKSGMLFNAAIVEAVAEVVKQRRLM-LVCDPVMVSTSGAALLEKEAVAKV 132

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLP  + ITPNLPEA  LL     +T  +  +  +        AVL+K GH    + 
Sbjct: 133 RELLLPVAAWITPNLPEAELLLGR-ELKTADQFADAAKECFDRWGAAVLLKTGHALSGKF 191

Query: 186 PDWLFTREGE-QRFTAPRIMTKN-THGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
                 REG+    +APR+     +HGTGCTLS+ALAA       W   V EAK++++ +
Sbjct: 192 VTDFVCREGKIYTLSAPRVPENGASHGTGCTLSSALAAGFALEMPWKQAVCEAKAFVTGS 251

Query: 244 LAQA 247
           L ++
Sbjct: 252 LRES 255


>UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=Q6CV88_KLULA
          Length = 539

 Score =  135 bits (341), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 91/265 (34%), Positives = 146/265 (55%), Gaps = 8/265 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LT+AG+D SGGAG++AD+KT SA G Y  + ITAL  Q    V S    +   +   L 
Sbjct: 58  VLTVAGSDSSGGAGVEADVKTISAQGCYAMTCITALTCQTPGKVYSFINTDEQHIKEILG 117

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
                +R D  KIGML     ++AV  +L + ++  +VLD VM+A SG PL S     + 
Sbjct: 118 HNLRSMRCDAIKIGML-NLGALKAVVSQLDQIKVP-IVLDPVMVATSGSPLSSGDVWESS 175

Query: 126 RSRLL-PQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +LL  +V+LITPN+PEA AL+  ++   +T  +M+   + + A     VL+KGGH   
Sbjct: 176 EIKLLMDKVALITPNIPEAKALIRDESYDLKTVSDMVALSKRVAADCRCNVLLKGGHCPI 235

Query: 183 E-QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           E +  D LF       + + R+ + N HGTGCTLS+ +A+    + +  + V ++  ++ 
Sbjct: 236 EGKVIDVLFVDGQVYIYNSDRLNSVNLHGTGCTLSSCIASKLAYNVSLPEAVYQSIQYVH 295

Query: 242 SALAQADTLEVGHGI--GPVHHFHA 264
           SA+   + ++V +    GP++H ++
Sbjct: 296 SAIICGENIKVTNCTENGPLNHIYS 320


>UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus
           RepID=A5DVD5_LODEL
          Length = 585

 Score =  135 bits (339), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 98/293 (33%), Positives = 145/293 (49%), Gaps = 45/293 (15%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGI+ADLKTFSA   YG + ITAL AQNT GV++      + V   L +
Sbjct: 22  LTIAGSDSSGGAGIEADLKTFSAFDVYGMTCITALTAQNTTGVKTYKETSRELVHEILKA 81

Query: 67  VFSDVR-------IDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLS 118
              D+        +   K GML ++ I     E L ++ ++  +V+D VM+  SG  LL 
Sbjct: 82  NLEDMYENEEKGPLKVIKTGMLTKSAI-----EELAQFDLKIKMVIDPVMVTTSGSKLLD 136

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLD--APHARTEQ--EMLEQGRSLLAM-GCGAV 173
              V      L+    L+TPN  EA  +       A+ +Q  E ++    L  M GC  +
Sbjct: 137 HEGVKLCVDNLMKNAFLVTPNFVEAETIYKILGKSAQVKQLDEFIKFTVDLQKMVGCKNI 196

Query: 174 LMKGGHL--------------DDEQSP---------DWLFTREGE--QRFTAPRIMTKNT 208
           L+KGGH+              + +  P         D L+  E +    F +  I + N+
Sbjct: 197 LVKGGHIPFDANGKVVEDTTAEGQAQPQSNPGLKVIDVLYESENDVVTIFESKYIESDNS 256

Query: 209 HGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           HGTGCTL++A+AA   + T+ AD+V     ++   + +   L  GHG GP++H
Sbjct: 257 HGTGCTLASAIAANIAKGTSLADSVAIGIDYIHQGMLKMSKL--GHGKGPLNH 307


>UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular organisms
           RepID=Q478V3_DECAR
          Length = 291

 Score =  135 bits (339), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 82/238 (34%), Positives = 132/238 (55%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L  A +DPS GAGIQADL T ++LG +  + +TA+  Q+T GVQSV+ +  + +  Q  +
Sbjct: 15  LVFAASDPSSGAGIQADLLTLASLGCHPLTALTAVTVQDTVGVQSVHPLAAELLEQQART 74

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D+ +   KIG+L   + V AVAE +  Y    ++LD V+ +  GD L S   ++ +R
Sbjct: 75  ILEDMPVVAFKIGVLGSVENVLAVAEIVSDYPEIPLILDPVLASGRGDDLSSEEIISAIR 134

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLPQ +L+TPN PEA  L ++    +E  +    + L+ MG   VL+ G H +  Q  
Sbjct: 135 EMLLPQTTLLTPNAPEARRLAESDEDESEPSIDICAQRLIEMGAQYVLITGTHENTPQVI 194

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + L+  +G  R      +  + HG+GCTL++A+A       +  D V++A+ +   AL
Sbjct: 195 NTLYGPDGVVRRDEWERLPGSYHGSGCTLASAIAGCIAGGASIEDAVRDAQDYTWQAL 252


>UniRef50_Q4P8E5 Putative uncharacterized protein n=1 Tax=Ustilago maydis
           RepID=Q4P8E5_USTMA
          Length = 642

 Score =  134 bits (336), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 92/213 (43%), Positives = 123/213 (57%), Gaps = 30/213 (14%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKTF +LG YG SV+TAL AQNT GV +++   PDFV  QL+S
Sbjct: 7   LTIAGSDSGGGAGIQADLKTFLSLGTYGLSVLTALTAQNTTGVSAIHACPPDFVLQQLES 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN---------VVLDTVMLAKSGDPLL 117
           V +D++ID  K+GML   +IV A+A +L+ ++            +VLD VM++ SG  LL
Sbjct: 67  VMADIQIDAVKMGMLCNHEIVAALATKLRHWKDSTGSHGGRDVPIVLDPVMVSTSGSLLL 126

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQ-------------------EM 158
           S  A+ TL   LLP  +++TPNLPE+  LL      T                     +M
Sbjct: 127 SEGAIETLIRELLPLCTILTPNLPESRQLLKYAAKFTSHQTGPKELELALNNESTELPQM 186

Query: 159 LEQGRSLLAMGCGAVLMKGGH--LDDEQSPDWL 189
           +   +S+  +G  AVL+KGGH  L   Q   WL
Sbjct: 187 MAAAKSIAKLGPRAVLVKGGHARLKRSQINAWL 219



 Score = 41.2 bits (95), Expect = 0.040,   Method: Compositional matrix adjust.
 Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 1/68 (1%)

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F  P I +  THGTGCTLS+A+AA   +  +   +   A +++  A+A     ++G G G
Sbjct: 326 FVKPLIDSTATHGTGCTLSSAIAASLAQGRSLLRSTATAITYVQHAIANG-IQDLGKGPG 384

Query: 258 PVHHFHAW 265
           P+ H + +
Sbjct: 385 PLDHSYPF 392


>UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus anthracis str.
           A0193 RepID=B0Q8A3_BACAN
          Length = 223

 Score =  134 bits (336), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 77/196 (39%), Positives = 112/196 (57%), Gaps = 5/196 (2%)

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSR 128
           +D+  D  KIGML  ++I++ VAE + ++   N+VLD VM+AK G  LL   AV  L+  
Sbjct: 22  ADLTPDAVKIGMLFSSEIIQIVAEYINKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEY 81

Query: 129 LLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP-- 186
           LLP  ++ITPN+PEA  L        E    E  + L  +G   VLMKGGH + + +   
Sbjct: 82  LLPVATVITPNVPEAEVLTGLEIHNIEDSK-EAAKVLHELGAKYVLMKGGHAEYQGNEVI 140

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D LF  E    F + RI +K THG+GCT ++A+ A   +  +  + VQEAK ++S A+  
Sbjct: 141 DLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSMEEAVQEAKRFISIAI-- 198

Query: 247 ADTLEVGHGIGPVHHF 262
            + L +G G GP +HF
Sbjct: 199 EEPLHIGSGHGPTNHF 214


>UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Lactobacillus brevis ATCC 367 RepID=Q03NL9_LACBA
          Length = 264

 Score =  133 bits (335), Expect = 6e-30,   Method: Compositional matrix adjust.
 Identities = 90/263 (34%), Positives = 136/263 (51%), Gaps = 12/263 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D   G GIQADLKTF  L  +G SV+T++V+     +++ +++  + +A QL
Sbjct: 3   NVLTIAGSDSLAGGGIQADLKTFEELHTFGLSVLTSVVSVLPDELKA-FQLPAEVMATQL 61

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            SVF  V I   K G+L     +    + L+  QI +VV+D VM+ K G   ++P  +  
Sbjct: 62  TSVFDQVPIKAVKTGLLGNLTALTLAVKCLRSSQI-SVVVDPVMVFKEGPLQVTPEYLTA 120

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L+  LLP  ++ TPNL EA  L        EQ M+   R + A+GC  V++KGG  L   
Sbjct: 121 LKETLLPLATITTPNLLEAQQLSGLTITNREQ-MVAAARQIQALGCPNVVIKGGSRLGGS 179

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            +PD L   +      AP I+   + G GCT SAA+ A   +     + V  AK ++ +A
Sbjct: 180 VAPDCLLIGDDVTWLEAPIILNAASDGAGCTFSAAITAQLAKGQELLEAVTFAKKFVHAA 239

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           +         HG+   H + + W
Sbjct: 240 IT--------HGVAISHDYGSVW 254


>UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomycetales
           RepID=A4XBK7_SALTO
          Length = 262

 Score =  133 bits (334), Expect = 7e-30,   Method: Compositional matrix adjust.
 Identities = 110/263 (41%), Positives = 147/263 (55%), Gaps = 6/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     LTIAG+D  GGAGIQADLK F+AL AYG SV+TA+ AQNTRGV +V  + P  V
Sbjct: 1   MTPSTVLTIAGSDSGGGAGIQADLKVFAALEAYGTSVVTAVTAQNTRGVDAVLPLPPQTV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV +D  +   K GML    + E VA   +  ++ ++V+D V++A SG  L + +
Sbjct: 61  TDQLESVLADFSVRAVKTGMLGSPAVAEVVAVAARDGRLPHLVVDPVLVATSGHRLGAVA 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV     RLLP   + TPN  EAAAL       T +EM+    +L A G   V++ GG  
Sbjct: 121 AV----ERLLPFAQVATPNRAEAAALTGG-RVDTVEEMVAAATALTAGGPEYVVVTGGDG 175

Query: 181 D-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           D  E + D L    G     A R+ T++ HGTGC+ SAA+A    R       V  AK +
Sbjct: 176 DAGEPAVDVLHGEGGTTLLRASRVPTRHNHGTGCSFSAAVAVRLARGDAVPVAVAAAKEY 235

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           ++ AL  A   E+G G GP+ HF
Sbjct: 236 VTRALIGARDWELGAGPGPLDHF 258


>UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolobaceae
           RepID=C3NMB3_SULIN
          Length = 456

 Score =  133 bits (334), Expect = 7e-30,   Method: Compositional matrix adjust.
 Identities = 74/255 (29%), Positives = 131/255 (51%), Gaps = 7/255 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            +T+AG D   GAG + DL+ F  LG +G   ITA+ AQ+T+G++ +  +  +F+  Q++
Sbjct: 18  GMTVAGLDTGNGAGGETDLRVFEVLGIHGVFAITAITAQSTKGIKDINVVSSEFLKKQIE 77

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D  ++  K+GM+   +  + V E L       +V+D V+ AK G PL+    V   
Sbjct: 78  TLLDDFNVEAVKMGMIYTKEQFQVVNELLHD---SFLVVDPVLYAKDGTPLIKD--VEDY 132

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +  +LP   +ITPN+ EA+A+      +    ++   +         V++KGGH   + S
Sbjct: 133 KKIILPIAKVITPNIIEASAISSIKVEKESDVVIACKKIRETYNIAHVIIKGGHSKGDFS 192

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D++   EG  +    RI  K+THGTG   + A  A   +  +     ++A+ ++ S + 
Sbjct: 193 FDYMCNEEGVYKIGYHRIQAKDTHGTGSVFATAFTAEYIKTKDVKLAFRKARDFVQSPIE 252

Query: 246 QADTLEVGHGIGPVH 260
               L +G G+GPV+
Sbjct: 253 YG--LNIGKGVGPVN 265


>UniRef50_Q0FHB8 Phosphomethylpyrimidine kinase ThiD n=2 Tax=Rhodobacteraceae
           RepID=Q0FHB8_9RHOB
          Length = 259

 Score =  132 bits (333), Expect = 8e-30,   Method: Compositional matrix adjust.
 Identities = 92/239 (38%), Positives = 132/239 (55%), Gaps = 13/239 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L I G D SGGAG+  D  T +A+G   C+ +TA+ AQ+   V+ V  + P  VA+Q+ +
Sbjct: 6   LCIGGIDSSGGAGLLRDAATLAAMGLESCAAVTAVTAQSDAAVREVQVMPPALVASQI-A 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
              +  +D  KIGML    +V+AVA  L     + +VLD V+++ SG  LL    +A L 
Sbjct: 65  AACEGPVDAVKIGMLGHAALVDAVASALPD---RPLVLDPVLVSTSGRSLLDDDGIAALL 121

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEM-LEQGRSLLAMGCGAVLMKGGH-LDDEQ 184
            RL+P+V+L+TPNLPE   L  A  A +E+ + L Q R     GC AVL+KGGH    E 
Sbjct: 122 GRLVPRVTLMTPNLPELDTLAAALGASSEKAIGLLQDR-----GCRAVLVKGGHDATPEV 176

Query: 185 SPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           + DWL+        F APR +     GTGC L++ +A    +H +    VQ AK  L++
Sbjct: 177 ATDWLYRASAPVAEFHAPR-LDGTLRGTGCQLASVIAGGLAQHLDIERAVQNAKHMLTT 234


>UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcanivorax
           RepID=Q0VSP4_ALCBS
          Length = 253

 Score =  132 bits (333), Expect = 8e-30,   Method: Compositional matrix adjust.
 Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 7/243 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L IAG DPSGGAGI AD++   ALG +  ++IT L  QN++ V+     E D +  Q 
Sbjct: 4   NILVIAGHDPSGGAGIHADIEAIQALGGFASTLITGLTVQNSQNVRGFRLTEIDLLQQQA 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D++  D+     KIGM     IV+ + + L+R     V+LD V+ A++G  L   S    
Sbjct: 64  DALLDDMDYQAIKIGMTGSIAIVDFITQLLKRLPNVPVILDPVLAAEAGGSLAQESLAEV 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +   L P   ++TPNLPEA AL        +Q +   G+ L+     A L+ G H D +Q
Sbjct: 124 MLDTLAPLCDVMTPNLPEAQAL------SGQQSVSGCGQVLVQRSGCATLITGTHDDTDQ 177

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             + LFT  GE+++   R +    HG+GCTL++++A LR    +    V   ++ +   L
Sbjct: 178 VVNHLFTPSGEEQWHWDR-LPHRYHGSGCTLASSIACLRGHGQSLHSAVANGQAHVDKFL 236

Query: 245 AQA 247
             A
Sbjct: 237 RNA 239


>UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosphate
           pyrophosphorylase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SG79_METPP
          Length = 532

 Score =  132 bits (333), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 97/257 (37%), Positives = 135/257 (52%), Gaps = 8/257 (3%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           +IAGTD  GGAG+ AD +   A G + C V++A+ AQN+  V  + R+ P  + AQL+++
Sbjct: 13  SIAGTDSGGGAGLSADQRAADAFGVHLCPVVSAVTAQNSLAVTRIERLPPLALEAQLEAL 72

Query: 68  FSDVRIDTTKIGMLAETDIVEAVA---ERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
             D+     K G+L   + V  VA   +RL+R Q   +V+D V+ A SG     P  +A 
Sbjct: 73  ADDLPPQVVKTGLLGGAEHVRRVAHWIDRLRRRQPVALVVDPVLAASSGATFADPDTLAA 132

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--D 182
            R  LLP+ +LITPN  EAAALL  P A T   +  Q  +L   G  AV + GG     D
Sbjct: 133 YRELLLPRATLITPNRREAAALLGQPEAGTAG-LPAQALALRRRGAQAVCITGGDAADLD 191

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            +  DW+ T + +    APRI T + HG+GCT +++ AA        AD +  AK     
Sbjct: 192 GRVLDWMATEQADGWLAAPRIATPHHHGSGCTFASSAAAALALGFVPADALVLAKMATGH 251

Query: 243 ALAQADTLEVGHGIGPV 259
           AL  A     G G GPV
Sbjct: 252 ALRHAH--PAGAGRGPV 266


>UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
           n=1 Tax=Schizosaccharomyces pombe RepID=THI21_SCHPO
          Length = 506

 Score =  132 bits (332), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 83/269 (30%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            +T+AG+D SGGAG+QADLK F+A   YG S +TA+ +QNT GV  V+ I   +V  Q+ 
Sbjct: 5   CITVAGSDCSGGAGVQADLKVFTAHSVYGMSAVTAITSQNTIGVNGVHLIPASYVEQQIS 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +   DV  +  K GML    I++ + E + R++I+ VV+D ++  + G  L+ P  +   
Sbjct: 65  ACLLDVHCEVMKTGMLFNQQILKVIVESIDRFKIKKVVVDPLIATRKGALLVMPDYLELF 124

Query: 126 RSRLLPQVSLITPNLPEAAALLD-APHARTEQEMLEQ----GRSLLAMGCGAVLMKGGHL 180
              L+P+  ++ PN+ EA  +L    +   E   LE     G+ L+  GC  V+++   +
Sbjct: 125 VKELIPRAEVLIPNIAEALIILKHMTNEFVEIHHLEDVKAVGKKLIKAGCKNVVIRCDDI 184

Query: 181 ----------DDEQSPDW----LFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRH 226
                     +    P W    L T EGE       + +K   GT C LS+A+A+     
Sbjct: 185 PFASDFFCSRETNMPPTWYLYVLCTSEGEVLLPQKWLASKTARGTSCALSSAVASNLAIG 244

Query: 227 TNWADTVQEAKSWLSSALAQADTLEVGHG 255
            +     Q A S+   AL    +  +G G
Sbjct: 245 LDLVTATQNAVSYTQRALEM--SFHLGRG 271


>UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax=Filobasidiella
           neoformans RepID=Q5KEL1_CRYNE
          Length = 561

 Score =  132 bits (332), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 114/314 (36%), Positives = 152/314 (48%), Gaps = 57/314 (18%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + +TIAG+D  GGAGIQADLKT  A G YG SV+T L AQNT GVQ+V+ +  DFV  
Sbjct: 14  RPHVMTIAGSDSGGGAGIQADLKTIEAFGCYGSSVLTGLTAQNTLGVQAVHVVPTDFVIQ 73

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL SV SD      K+GML     + A+A  + +     +VLD VM++ SG  LL   A+
Sbjct: 74  QLQSVISDELPKAIKLGMLTCASTIRALAREVSKLN-TTIVLDPVMISTSGHTLLPDDAM 132

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHA-RTEQEMLEQGRSL-LAMGCGAVLMKGGHL 180
             L   L P V  +TPN+PEA  L    H  +   +M+E  +         +VL+KGGH 
Sbjct: 133 EALY-ELYPHVDYLTPNIPEAKNLSGWSHEIKNLDDMIELAKKTNETTKSPSVLLKGGHA 191

Query: 181 ---------------------DDE-----------QSPDW-----------LFTREGE-- 195
                                DDE           +S D            L  +EGE  
Sbjct: 192 IVSREEVLKYAGKYELIWEEGDDEDDAVEVYNEYKESLDINIKTQKDLVVDLLIKEGEII 251

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWAD------TVQEAKSWLSSALAQADT 249
             F   ++ +++THGTGCTLSAA+A      +  AD        + A  +  SA+A A  
Sbjct: 252 AMFVGKKVDSQSTHGTGCTLSAAIACSIAVSSEVADAKSLISVFKRAIGYTQSAIATA-- 309

Query: 250 LEVGHGIGPVHHFH 263
              GHG GP++H H
Sbjct: 310 FPFGHGHGPLNHGH 323


>UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular organisms
           RepID=B9LWE4_HALLT
          Length = 461

 Score =  132 bits (331), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 104/259 (40%), Positives = 144/259 (55%), Gaps = 5/259 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D  GGAGIQADLKT  A GA+G S ITA+ AQNT GV S + +  + + AQ+D+
Sbjct: 22  LTIAGSDSGGGAGIQADLKTIEAGGAFGTSAITAVTAQNTLGVVSSHVLPIEEIDAQIDA 81

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD  +   K GMLA   ++  V E         VV+D VM+A +GD LL+P A   + 
Sbjct: 82  VLSDFDVRAVKTGMLATAPVIAVVTE-YVDDLDVPVVVDPVMVAATGDRLLAPDA-ENVY 139

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL   +L TPN  E A +L        +  ++ G++LL  G  A L+KGGH+  ++  
Sbjct: 140 EDLLAHAALTTPNADE-AEVLTGIELTDHEGTIQAGKALLETGVDAALVKGGHVPTDRVR 198

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D L T +  + +  PR+ T  THG+GCTL++A+          AD V    S++  A+  
Sbjct: 199 DVLVTADDVKTYEHPRVDTDATHGSGCTLASAITTRLAHDEPLADAVDAGVSFIERAVRY 258

Query: 247 ADTLEVGHGIGPVHHFHAW 265
              L+VG G G VHH  A 
Sbjct: 259 --HLDVGEGPGSVHHMVAL 275


>UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U779_HYDS0
          Length = 259

 Score =  132 bits (331), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 71/246 (28%), Positives = 135/246 (54%), Gaps = 6/246 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK I  L  AG D + GAG+ AD +T + +GA+   + T+ V QNT+GV+ V  +EPD +
Sbjct: 1   MKSI-VLVFAGYDQTSGAGVIADARTITCIGAHPVCITTSFVIQNTKGVKEVIFLEPDII 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
              +D +  DV+    KIG++ +   +  +++ +   + ++VV+DT + +K+  PL    
Sbjct: 60  KKHIDIL--DVKPKVVKIGVVGDDKAIRLISKAIDTLKPEHVVVDTPLFSKNDTPLF--K 115

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           ++   +  ++ + ++ITPN+ E A+ +     +T+ ++ +     L MG   V++KGGH 
Sbjct: 116 SLELYKDLIVSKATIITPNIKE-ASFITGIDIKTKNDIEQAANVFLDMGVKHVVIKGGHR 174

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +DE   D+  + E         I T+ THGTGC  ++++A+      +   ++ +AK ++
Sbjct: 175 EDEPGVDFYKSMEESFEIKKDFIETRTTHGTGCVYASSIASYLAIGNDVKASIIKAKDYV 234

Query: 241 SSALAQ 246
             A+ Q
Sbjct: 235 DRAIKQ 240


>UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI000178943A
          Length = 335

 Score =  132 bits (331), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 83/174 (47%), Positives = 109/174 (62%), Gaps = 1/174 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADLKTF  LG YG S ITA+  QNT GV  VY + P+  A Q++
Sbjct: 9   ALTIAGSDSGGGAGIQADLKTFQELGVYGMSAITAITVQNTMGVHGVYPLPPEATAEQIE 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V SD+ +D  K GML   +I+  VA+R++ +    VV+D VM+AK G  LL   AV  L
Sbjct: 69  AVGSDLGVDALKTGMLFNAEIIRLVADRIRAFGWGKVVVDPVMIAKGGAELLQSEAVQAL 128

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           R  LLP   ++TPN+PE A +L     RT  +  E  R +  +G   V++KGGH
Sbjct: 129 REDLLPLALIVTPNIPE-AEVLAGMRIRTMNDRNEAARRIHDLGPRIVVIKGGH 181


>UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosaccharomyces
           japonicus yFS275 RepID=B6K6F0_SCHJY
          Length = 376

 Score =  131 bits (330), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 83/265 (31%), Positives = 135/265 (50%), Gaps = 21/265 (7%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LT+AG+D SGGAG+QADLK   A   YG SV+T + +QN+ G+  V+ I    +  Q +
Sbjct: 67  CLTVAGSDSSGGAGLQADLKAILAHKVYGMSVVTCITSQNSTGLHDVFPIPAPLIEQQFN 126

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +  +DV     KIGML++ D ++AV   L RY+++NVV+D+V++   G+ +    A+ +L
Sbjct: 127 ACLADVECHAVKIGMLSDVDSIQAVVRALDRYKVKNVVMDSVIVTNRGNVMCQKRALRSL 186

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQG------RSLLAMGCGAVLMKGGH 179
              L+P+V +   N+ EA  L+     R+   M   G        L  +G   V++KG H
Sbjct: 187 IRDLIPRVLVFGSNIMEACLLVKGATGRSFTSMRSFGDICKLLEELWKLGPKYVILKGHH 246

Query: 180 --LDD---------EQSPDWLF--TREGEQRFTA--PRIMTKNTHGTGCTLSAALAALRP 224
              D+         ++ P W      +G Q +    P +   N  GT C+L+A++A+   
Sbjct: 247 VAFDNRLRIVENASQRQPLWTIDTVYDGSQIYIVHKPYVSNYNVRGTSCSLTASVASNLA 306

Query: 225 RHTNWADTVQEAKSWLSSALAQADT 249
                   +++A S +  AL   DT
Sbjct: 307 LGKPPLIAIRDAISMVEIALEHIDT 331


>UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bacteroides
           RepID=B3JHT8_9BACE
          Length = 288

 Score =  131 bits (330), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 84/264 (31%), Positives = 138/264 (52%), Gaps = 7/264 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K      IAG++P G AG+QAD+K+ SA G Y    IT +V ++T  V+S+  I  + V 
Sbjct: 6   KLYKVFLIAGSEPLGTAGMQADIKSISACGGYAAGAITCIVDEDTIKVKSIQTIPVEMVV 65

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           +Q  S   DV  D  K GML   ++V A+ + +++  I  +V+D VM++ +GD LL   A
Sbjct: 66  SQTYSFLEDVGADCIKTGMLYSQELVTAIGDVVKKQSIP-IVVDPVMVSSAGDKLLQDDA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +   +  L P  ++ITPN  EA  LL    + T+  M E    L   G   V++K    D
Sbjct: 125 IQAYKDCLFPYSTIITPNRREADLLLG--KSLTKDNMKEYIPELSKWG-NCVIVKSIE-D 180

Query: 182 DEQSPDWLFT--REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +   D  +    +  + +   RI TKN +GTG T ++++A    R  +    V +A+++
Sbjct: 181 GDYLIDVFYNPISKCFKLYKKARIQTKNVNGTGDTFASSIATYLARGYDMNTAVDKAENF 240

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           + +A+     ++ G G GPV+ F+
Sbjct: 241 IYNAILYGSNVKFGSGYGPVYPFY 264


>UniRef50_C8PKC3 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter gracilis
           RM3268 RepID=C8PKC3_9PROT
          Length = 366

 Score =  131 bits (329), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 83/180 (46%), Positives = 113/180 (62%), Gaps = 3/180 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++I  LTIAG+D  GGAGIQAD+KT SA   +  S ITAL AQN+RGV  V  + PDFV
Sbjct: 1   MRKI--LTIAGSDSGGGAGIQADIKTISAHKMFAMSAITALTAQNSRGVFGVLDVSPDFV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQLD++FSD+  D  KIGM++   + EA+A+ L ++  +NVVLD VM+A SG  L+  S
Sbjct: 59  GAQLDAIFSDIFPDAVKIGMISNEGVAEAIAKSLSKHGAKNVVLDPVMVATSGGVLMKQS 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L+  L P   +ITPN+ EA  L +     +  +M      +     GA+L+KGG L
Sbjct: 119 ALHALKYELAPAAEIITPNVREAEVLAEM-KISSLADMRAAAVKISQFFSGAILIKGGDL 177



 Score = 61.2 bits (147), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 2/109 (1%)

Query: 154 TEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGC 213
            E+   EQ  S  ++G G    + G      + D L+       F+AP+I T+NTHGTGC
Sbjct: 235 NEKPSFEQNLSAASLGAGFEPSREGADLTNFAVDILYENGKFYEFSAPKISTRNTHGTGC 294

Query: 214 TLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHF 262
           TLS+A+A       +    V  AK ++  AL   +  ++GHG G + H+
Sbjct: 295 TLSSAIACALAAGLSLPRAVAHAKGFVRRALGWGE--QIGHGCGAIDHY 341


>UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7E450_SCLS1
          Length = 400

 Score =  131 bits (329), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 88/236 (37%), Positives = 133/236 (56%), Gaps = 27/236 (11%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG+D SGGAG++AD K  +A   Y  +  TAL AQNTRGV+ ++ I  +FV   +D 
Sbjct: 7   LVIAGSDSSGGAGLEADQKVIAAHECYAMTATTALTAQNTRGVEDIHHIPAEFVGKLIDV 66

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
              D+ +D  K    A  + VE VA+ L+R+ ++ +++D VM++ SG  LL   A+  LR
Sbjct: 67  TIGDMGVDVVKT---ASAETVEVVAKALKRHHVKTLIVDPVMISTSGTQLLPSIAIRHLR 123

Query: 127 SRLLPQVSLITPNLPEAAALL-DAPHARTEQEMLEQ----GRSLLAMGCGAVLMKGGHL- 180
             LLP  +++TPN+PEA  LL DA     E + L+      + + ++G   VL+KGGHL 
Sbjct: 124 ELLLPYTTVLTPNVPEAKLLLSDAGKFVEEPKNLDDLKNIAKEVQSLGPRYVLVKGGHLP 183

Query: 181 ------------DDEQSPDWLFTREGEQRFTAPRIM---TKNTHGTGCTLSAALAA 221
                       + E   D L+   GE   T  R     ++NTHGTGC++++A+A+
Sbjct: 184 LRKDGTVATKEEEKELMVDILY---GEGVITEIRTKYQNSRNTHGTGCSMASAIAS 236


>UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine archaeal group 1
           RepID=A9A225_NITMS
          Length = 432

 Score =  131 bits (329), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 77/253 (30%), Positives = 140/253 (55%), Gaps = 6/253 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +N L+I G+DPS GAGIQ+D++ FSALG +  +VITA+ +QNT     V  +    +  Q
Sbjct: 1   MNILSIGGSDPSSGAGIQSDIRVFSALGVHTLTVITAITSQNTSKFGMVEPVSSKILQKQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L+SVFSD +I+  KIGM+  + I++ + ++L++ +I  +V+D V+ + +G  L+  +A  
Sbjct: 61  LESVFSDFKINGVKIGMVYNSKIIKIIHQQLKKLKIP-IVVDPVIRSTTGGSLIENNARK 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
             +  ++P  ++ITPN  EA  LL      T+    +  + +  MG   V + G   + +
Sbjct: 120 DFQKYIVPLATIITPNKKEAE-LLTKMKISTKNTPEKVAKEIQNMGAKNVTITGIE-EKK 177

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D++  +  +   +  +I   N HG+GC  SAA+     +  +  +++  AK +   +
Sbjct: 178 KVSDFVLEKNSKYIISGEKIPKIN-HGSGCIHSAAVVYSLAKKKSIKESLYFAKKFTYKS 236

Query: 244 LAQADTLEVGHGI 256
           +  A   ++G GI
Sbjct: 237 IKNAK--KIGKGI 247


>UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9D1C6_WOLRE
          Length = 260

 Score =  130 bits (327), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 88/246 (35%), Positives = 130/246 (52%), Gaps = 11/246 (4%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           + N L IAG+D  GGAGIQAD+KT  A G Y  + ITAL AQNT GV +V  + P+F+ A
Sbjct: 5   KKNILIIAGSDSIGGAGIQADIKTCEAYGCYSATAITALTAQNTSGVSAVMPVTPEFLNA 64

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL++V ++++ D  KIGML    ++  V   L++ +  + V+D V +AKSG  LL   A+
Sbjct: 65  QLEAVCAELKFDAVKIGMLFNEQLIACVKAWLEQNRGISAVIDPVCVAKSGAKLLQDGAI 124

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L+  LL    + TPNL EA  L        + E L  G  L    C  VL +      
Sbjct: 125 NALK-ELLSLARIATPNLDEARIL----GLNFDGERLNLGADL---PCDIVLKR--TQTS 174

Query: 183 EQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           E   D L+ + GE  +F  P       HG GC+ + A+A       +    ++ AK++++
Sbjct: 175 EICEDTLYQKSGEIVKFGEPLERPTIMHGAGCSFATAIACALACGADEITAIKHAKAFVA 234

Query: 242 SALAQA 247
           +A+  A
Sbjct: 235 NAIKNA 240


>UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_SYNE7
          Length = 263

 Score =  129 bits (323), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 103/259 (39%), Positives = 144/259 (55%), Gaps = 5/259 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+D  GGAGIQADL+TF+    +G   IT + AQNT GV  V  I P  VAAQLD
Sbjct: 6   ALTIAGSDSGGGAGIQADLRTFAFHQVHGTCAITCVTAQNTLGVTRVDAIAPAGVAAQLD 65

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V SD+     K GML   +I+E VA  +    I  ++ D VM++++G  L+  +A+A L
Sbjct: 66  AVLSDLPPQALKTGMLLNAEIMEVVAGTIAPLFIPRII-DPVMVSRTGAVLIDQAAIAVL 124

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDEQ 184
           R  LLP  +++TPN  E A LL     +   ++    R +  +G  AVL+KGG    D  
Sbjct: 125 RDHLLPLATVLTPNRYE-AQLLAGMDIQDAADLDRAARIIRDLGPQAVLIKGGAATGDWH 183

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             DW +  +         I T +THG+GCTL+AA+AA            Q AK +++ AL
Sbjct: 184 GVDWWWDGQQSHILKTEAIATPHTHGSGCTLAAAIAANAALGLEILAAAQAAKHYVTKAL 243

Query: 245 AQADTLEVGHGIGPVHHFH 263
               +L +G G GP+ HF+
Sbjct: 244 RH--SLAIGQGQGPLGHFY 260


>UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Mannheimia haemolytica
           RepID=A7JV63_PASHA
          Length = 509

 Score =  128 bits (322), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 84/246 (34%), Positives = 125/246 (50%), Gaps = 8/246 (3%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           T+AG+D   GAG+Q DL TF      GCSV+T++ AQ+  GV  V  ++      Q +++
Sbjct: 16  TVAGSDSCAGAGLQTDLHTFHDFNLVGCSVVTSVTAQHPHGVLCVTPVDDHTFRQQFEAL 75

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-----VVLDTVMLAKSGDPLLSPSAV 122
                 +  KIG+L     VE + E +Q+ + ++     VV D V +A SG  L     +
Sbjct: 76  LVQGYPNAIKIGLLCSQAQVEILCEYIQKIRAESSHYCYVVYDPVAVASSGQALSDSILL 135

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD- 181
             ++ +L P V LITPN  E A L D    +T  ++      L A G  AVL KGGH + 
Sbjct: 136 QIVQQKLYPLVDLITPNGTELALLSDT-EIQTFGDVKTASHKLFAQGIKAVLAKGGHFEW 194

Query: 182 -DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             E   D+L T      F+  R  + NTHGTGCT ++A+ A+     + AD V  A ++L
Sbjct: 195 LGETVRDYLLTANEIYAFSHARQQSVNTHGTGCTYASAVGAMLATGFDLADAVTVATAYL 254

Query: 241 SSALAQ 246
              L++
Sbjct: 255 QKGLSE 260


>UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanocorpusculum labreanum
           Z RepID=A2SRR0_METLZ
          Length = 266

 Score =  128 bits (322), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 86/239 (35%), Positives = 123/239 (51%), Gaps = 3/239 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A TIAG+DPS GAGIQ DLKT +A G +G +VI AL AQN   V     +   F+  Q+D
Sbjct: 4   AATIAGSDPSAGAGIQVDLKTMAACGVWGMTVIAALTAQNATHVLDSSSVPAAFIKKQID 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D  I   K GML   + V  VA  +   + +N+V+D V+LA     LL  +    L
Sbjct: 64  ALEEDFPIGCYKTGMLKNAETVNIVAASIP--EGRNLVVDPVLLATKEYRLLDEAGQERL 121

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            + LLP+ ++ITPN+PEAAAL       +E  M E     +  G  A ++KGGH      
Sbjct: 122 VAELLPRTTVITPNIPEAAALSGITITGSES-MEEAAYWFIDHGAKAAVIKGGHAHFRLG 180

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D    ++G            + HG+GC  ++A+AA         D V EAK +++ A+
Sbjct: 181 TDVFADKDGIMLVEGEVAPFTDVHGSGCCYASAIAAHIALGYPVRDAVLEAKKFVTGAI 239


>UniRef50_A0Y7H0 Phosphomethylpyrimidine kinase ThiD/thiamin-phosphate
           pyrophosphorylase fused protein ThiE n=1 Tax=marine
           gamma proteobacterium HTCC2143 RepID=A0Y7H0_9GAMM
          Length = 272

 Score =  127 bits (319), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 86/255 (33%), Positives = 139/255 (54%), Gaps = 7/255 (2%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           TI+ +   GG GIQADL TF     YGC+V+TAL AQN+         E   VAAQ++++
Sbjct: 6   TISASAAGGGTGIQADLHTFHDFDVYGCTVVTALCAQNSFASGYTAVTEKKAVAAQINAL 65

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
            SD+  D  K+G+L   DIVE+V + L+ +  +  V+  + L  SG+ LL  +    +++
Sbjct: 66  DSDMPADAIKLGILPSKDIVESVIKYLEDF--KGFVVYDLELENSGEVLLGEAG-ELVKT 122

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPD 187
            L+P+V+L+  N+ EA AL     +  E  + +  R LL MG G+VL+ G H+ D++   
Sbjct: 123 VLIPRVNLLVVNVDEAKALTGIAVSSGES-LADTARVLLGMGAGSVLVTGAHIGDKRVDL 181

Query: 188 WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
           W+ + +  Q  T   + T N  G G  LSA + A   R  +   +++ AK++++  +   
Sbjct: 182 WM-SGDRCQWVTIDPLHTANNRGGGNVLSAVMTAAEARGLDIETSLKLAKAYVTQGIRG- 239

Query: 248 DTLEVGHGIGPVHHF 262
            + +VG G G V H 
Sbjct: 240 -SYQVGSGPGAVAHL 253


>UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=Lactobacillus sakei
           subsp. sakei 23K RepID=Q38VX7_LACSS
          Length = 264

 Score =  127 bits (318), Expect = 5e-28,   Method: Compositional matrix adjust.
 Identities = 81/256 (31%), Positives = 130/256 (50%), Gaps = 3/256 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D  GG G+QADLKTF A G +G S +T L          +  IE + V AQ+
Sbjct: 3   NILTIAGSDTLGGGGLQADLKTFEAFGHFGVSAVTCLATVMPDQTFQIQNIETETVLAQI 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++   V + T KIG++ +   +E +   LQ+     ++ D V+  K     L    + +
Sbjct: 63  EAILHYVPLTTIKIGLINDATTLEKIGHLLQKQPHLQIITDPVLAFKETTDKLQQHYLDS 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDE 183
           L+  LLPQ  ++TPNL EA  L   P  +T  E+ +    + ++G   V++KGG     +
Sbjct: 123 LKDVLLPQSLVVTPNLVEAQLLSGLPQIQTRAELEQAATIIQSLGPQHVVIKGGQRFPGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L +       +APR+ +   +G GCTLSAA+ A           V+ AK ++   
Sbjct: 183 DAIDLLHSGTTNHYLSAPRLTSATRNGAGCTLSAAITAEIASGHAVYPAVKAAKQFVYHG 242

Query: 244 LAQADTLEVGHGIGPV 259
           +   + +++ HG G V
Sbjct: 243 I--QNGIQLRHGFGNV 256


>UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax=Enterococcus
           faecium RepID=C2HB32_ENTFC
          Length = 275

 Score =  126 bits (317), Expect = 6e-28,   Method: Compositional matrix adjust.
 Identities = 77/248 (31%), Positives = 132/248 (53%), Gaps = 3/248 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKRI  LTI G+DP  G GIQ DLKTF   G +G S +T++   +T G   +  I  + +
Sbjct: 6   MKRI--LTIGGSDPFAGGGIQTDLKTFEDFGLFGLSALTSIGVLDTNGRFILESIPSELL 63

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL S+     +D  KIG+L  ++ +  V + ++  Q   ++LD V+  K  + +++  
Sbjct: 64  ERQLASIDQMTSLDGIKIGLLNSSEAIMVVRDFIKAKQNIPIILDPVLAFKETETVINQW 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-H 179
            ++ L   L P V++ITPNL EAA L       +  EM+   + L A G   +++KGG  
Sbjct: 124 YISQLIEELFPLVTMITPNLAEAALLSGQALPSSLIEMIHLAKELTASGAKKIVIKGGTR 183

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +  EQ+ D L++ +  + F+  ++ T   +G GC  S+A+ A     T+ +  V E+K +
Sbjct: 184 MAGEQAVDLLYSVDHHEVFSQKKVDTPTVNGAGCAFSSAITANLVLGTDVSKAVAESKKF 243

Query: 240 LSSALAQA 247
           ++  ++  
Sbjct: 244 VAHCISNG 251


>UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular organisms
           RepID=Q7R735_PLAYO
          Length = 391

 Score =  126 bits (317), Expect = 6e-28,   Method: Compositional matrix adjust.
 Identities = 81/216 (37%), Positives = 119/216 (55%), Gaps = 8/216 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+++G DP+GGAGIQAD++   A+G   C+VITAL  Q+T  V +V    PD   AQ  +
Sbjct: 136 LSLSGHDPTGGAGIQADIEAVGAIGCRACTVITALTIQDTSNVHAVQPQSPDAFLAQGRA 195

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATL 125
           +  D+ +   KIG+L    I   VA  L        VVLD V+ A  G  L S   +  +
Sbjct: 196 LIRDLPVAAVKIGLLGSAGIAHCVATLLDELGGGVPVVLDPVLAAGGGTDLASEELIEAV 255

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R+ LLP+  L+TPN+PEA+ L       TE E  E+   L  +GC  VL+ G H   +  
Sbjct: 256 RTELLPRAVLVTPNVPEASRLGG---GATEAENAER---LRLLGCPNVLITGTHAPTDDV 309

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
            + L++  G++ +  PR +  + HG+GCTL+A +A 
Sbjct: 310 VNRLYSSTGKRDYRWPR-LPYSYHGSGCTLAAXVAG 344


>UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0L0X1_HALNC
          Length = 285

 Score =  125 bits (315), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 87/252 (34%), Positives = 139/252 (55%), Gaps = 7/252 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L  +G DPSGGAG+QAD++   + G +  +VITAL  Q+T  V+     +P  V  Q  +
Sbjct: 12  LVFSGHDPSGGAGVQADIEAIISQGVHPATVITALTVQDTVDVKRFVPTDPSLVIEQARA 71

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+ +   KIGM+    +VE +   L+ Y    VVLD V++A  G  L +      + 
Sbjct: 72  VLEDMPVQCIKIGMIGSVALVEVIHSILKDYPDIPVVLDPVLIAGGGGALANEDVAKAMI 131

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           + LLP  +++TPN  E+ AL+   H     ++  +G+ LL MG   VL+KGG     +  
Sbjct: 132 NLLLPLTTILTPNAYESRALVKVAHVPA-NDLDARGQVLLEMGPEYVLLKGGDEQSTEVE 190

Query: 187 DWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHT--NWADTVQEAKSWLSSA 243
           +WL+TR +  ++FT  R +    HG+GCTL++A+A L  + T  ++ + + EA+ + S A
Sbjct: 191 NWLYTRHQPPRKFTYER-LPGEFHGSGCTLASAIAGLIAQATDADYVNAIHEAQEYTSHA 249

Query: 244 LAQADTLEVGHG 255
           L  A   ++G G
Sbjct: 250 LFHA--AQIGRG 259


>UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JTI6_9GAMM
          Length = 288

 Score =  125 bits (315), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 88/253 (34%), Positives = 130/253 (51%), Gaps = 14/253 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L ++G DPSGGAGI AD++  S+ G   C  ITA+  QN+R V SV+ ++P+ +  Q  +
Sbjct: 8   LCLSGFDPSGGAGIGADIEALSSQGCQACGAITAMTVQNSRDVISVHPVDPNVIIQQARA 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLA-KSGDPLLSPSAVATL 125
           V  D+ +   KIG++   ++  A+   L  Y    VVLD V+ +  SG  L     V  +
Sbjct: 68  VLEDMPVAVIKIGLVGSVEVAAAIHSVLSDYPDIPVVLDPVLASGGSGRALADDGLVEAI 127

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            + L+PQ +LITPNL EA  L+     R    +      L+  G  +VL+ GG   DE  
Sbjct: 128 LNLLVPQATLITPNLREAHTLIAGADTRQAAAI-----GLMEAGAQSVLLTGG---DEPG 179

Query: 186 PDWLFTREGEQR----FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            D L T   EQR    +  PR +    HG+GCTL+A+ A L        + V+ A+ +  
Sbjct: 180 DDVLNTLFAEQRWVRDYHWPR-LPHQYHGSGCTLAASAAGLIAHGILLEEAVEGAQEYTW 238

Query: 242 SALAQADTLEVGH 254
           +AL  A  L +G 
Sbjct: 239 NALYNAVRLGMGQ 251


>UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonella
           RepID=A9IRG3_BART1
          Length = 259

 Score =  125 bits (315), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 77/238 (32%), Positives = 123/238 (51%), Gaps = 1/238 (0%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L +AGTDP+GGAGI  D++T +         IT +  Q+   V  +  +    +AAQ+  
Sbjct: 15  LIVAGTDPTGGAGIVRDIETAAYFHIKANLAITCVNVQDDHHVAEIVPMNEKLIAAQMRI 74

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
                 I   KIGM     I+ A+   L+ Y    V+LD V++A SG  L +   +  + 
Sbjct: 75  ALEANPIRAIKIGMTGNQAIIAAICRVLEDYPHIPVILDPVLVASSGGKLTTEKIIEIMI 134

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           ++LLP V+L+TPN  E A L   P A   +E ++Q + LL++G  ++L+KGGH +   + 
Sbjct: 135 NQLLPYVTLLTPNRDELALLSQTPLASHHEETIQQAKKLLSLGARSILVKGGHAEGPLAI 194

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           D    +      +APR +     GTGC LS+A+AA    +      V++AK++  + L
Sbjct: 195 DSFIDKMEVINISAPR-LKGTMRGTGCILSSAIAAHLALNEPLISAVKKAKAYTHTLL 251


>UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UMB7_AKKM8
          Length = 257

 Score =  125 bits (314), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 91/244 (37%), Positives = 130/244 (53%), Gaps = 12/244 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +TIAG+D S GAG+QADLK   A+GA+  + +T +V++    V+ +  ++P  VA Q+  
Sbjct: 2   MTIAGSDCSAGAGLQADLKAAHAMGAFALTAVTCVVSEAPGTVRGIQEVDPSLVADQVRI 61

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
                 +   K GML    IV AV   L    I  VV+D VM+A +GD L+   AVA   
Sbjct: 62  NLEHFPVRAVKTGMLYSPAIVRAVHGVLDGADIP-VVVDPVMIATAGDRLMREEAVAVYE 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSL-LAMGCGAVLMKGGHLDDE-- 183
             LLP  +L+TPNL EAA LL +       E+ E    L +  GC  VL+KGGHL+ +  
Sbjct: 121 ELLLPGAALLTPNLDEAAVLLRSSVNPGRDELPEAAARLAVRYGC-PVLLKGGHLEGDCR 179

Query: 184 ---QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                PD     + E+    PR+   +THGTGC+LSAA+AA           V+    ++
Sbjct: 180 DVLSGPDGCLLGQWER----PRVQDVSTHGTGCSLSAAVAARLAAGDGLVAAVERGLEFI 235

Query: 241 SSAL 244
           +SA+
Sbjct: 236 ASAI 239


>UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
           C18B5.05c n=1 Tax=Schizosaccharomyces pombe
           RepID=YJK5_SCHPO
          Length = 327

 Score =  125 bits (313), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 74/236 (31%), Positives = 129/236 (54%), Gaps = 21/236 (8%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D SG AGIQADLK  +A   YG SV+TAL  QN+ G+  +Y + P  +  Q+D
Sbjct: 16  CLTIAGSDCSGAAGIQADLKVMTAHQVYGMSVLTALTCQNSHGITGIYPLHPSLIQRQID 75

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL-SPSAVAT 124
           +  SD++    KIGML +   +  +++ L +Y+I +VV+D+V+++  G+ +  +P+  AT
Sbjct: 76  ACLSDIQCRVVKIGMLPDPKSIPVISQALTKYKITDVVMDSVIISSMGNVMCETPTIPAT 135

Query: 125 LRSRLLPQVSLITPNLPEAAALLDA------PHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
           ++  L P + +   N+ EA  L++       P  ++  ++      +  +G   V+++G 
Sbjct: 136 IQ-HLFPHLLVYASNVMEAFILVEKTLKKSPPPLKSFPDIQNLMSIIHRLGPKFVVLRGH 194

Query: 179 HL-----------DDEQS--PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
           H+            D +S   D ++  +    F  P   TK+ HG  C+L+AA+A+
Sbjct: 195 HVAFDKNMMITEKPDSKSWTADLIYDGKEFYIFEKPYNTTKSIHGESCSLTAAIAS 250


>UniRef50_Q9XDA0 Phosphomethylpyrimidine kinase (Fragment) n=3 Tax=Clostridium
           RepID=Q9XDA0_CLOCL
          Length = 169

 Score =  125 bits (313), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 62/163 (38%), Positives = 100/163 (61%), Gaps = 8/163 (4%)

Query: 109 LAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGR 163
           ++KSG  LL P A   L ++L+P  ++ITPNLPEA  +L     +    +T +EM +  +
Sbjct: 1   ISKSGYSLLKPEAKTALITKLVPLATVITPNLPEAEEILKEVNSNIKEIKTVEEMDKAAK 60

Query: 164 SLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALR 223
            +  +GC  V +KGGHL+ E + D L+  +    F + RI TKNTHGTGCT+S+A+AA  
Sbjct: 61  EIYKLGCKNVFLKGGHLEGE-AIDVLYDGKELTHFYSKRIQTKNTHGTGCTISSAIAANL 119

Query: 224 PRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
               +  D +Q+AK +++ A+    +L++G G+GP +HF+  +
Sbjct: 120 ALGYSVKDAIQKAKEYITIAIKH--SLDIGKGVGPTNHFYNLY 160


>UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacter butzleri RM4018
           RepID=A8EVM9_ARCB4
          Length = 251

 Score =  124 bits (310), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 85/257 (33%), Positives = 141/257 (54%), Gaps = 13/257 (5%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D  GGAGIQAD+K+    G +  + ITA+  QNT GV +V  ++P FV  Q+ 
Sbjct: 4   VLTIAGSDSGGGAGIQADIKSGFYHGIFMTTAITAITVQNTLGVTNVEVLKPSFVQEQIS 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           SV  D +++  KIGML   +++  V + ++   I  ++LD V ++++G  L+   A+ TL
Sbjct: 64  SVLEDFKVNAIKIGMLGSKELILKVLDCIKPLYIP-IILDPVAISRAGSKLIDDEAIETL 122

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           ++ L     +ITPN  EA    D          ++  +++  +    +L K    D  ++
Sbjct: 123 KT-LFKYAFVITPNKYEAKLFFDV-------NSIDDIKNIKHIPTN-ILFKNMVEDKNKT 173

Query: 186 PDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D L  ++G    F + R    NTHGTGC+ SA++A+L  +     D+++ AK ++  A+
Sbjct: 174 VDVLLKKDGTIINFESKRADESNTHGTGCSFSASIASLVAKGETLEDSIKIAKKYIYEAI 233

Query: 245 AQADTLEVGHGIGPVHH 261
             A  L  G+G GP++H
Sbjct: 234 KHAPNL--GNGNGPINH 248


>UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VXY4_MARMS
          Length = 513

 Score =  123 bits (309), Expect = 6e-27,   Method: Compositional matrix adjust.
 Identities = 85/257 (33%), Positives = 132/257 (51%), Gaps = 8/257 (3%)

Query: 9   IAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVF 68
           + G+D S  AG+QADL+T   L  +  +++T + AQN++ V+SV  +       Q  ++ 
Sbjct: 11  VGGSDSSAHAGLQADLRTGQDLRCHVQTIVTCITAQNSKEVRSVEPVSLAMFDEQWQTLL 70

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN----VVLDTVMLA--KSGDPLLSPSAV 122
            DV  D  K+ +L   +I +A +  L+R +       VV D VM A  +SG+ L   S  
Sbjct: 71  DDVPPDAIKVSLLPSIEIAKACSIWLRRIKADFPNVLVVFDPVMAASSESGNRLQQDSVG 130

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A+L   LLP + +ITPN  E   L      +   ++  Q    L+    A L+K GH D 
Sbjct: 131 ASLLGSLLPYIDVITPNSIEFKRLTGLSDQQPAVDIQGQLAVYLSSSKCAWLLKAGHSDS 190

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           EQ+ DWL  ++    F   R+   NT GTGCTLS ALA+      +  D +  AK++++ 
Sbjct: 191 EQATDWLLDQDSIVGFAYKRLSVHNTRGTGCTLSTALASFIAHGYDLLDAMTMAKAYITG 250

Query: 243 ALAQADTLEVGHGIGPV 259
           AL     +++G G GP+
Sbjct: 251 ALKTG--VQIGEGAGPL 265


>UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella sp. oral taxon
           472 str. F0295 RepID=C9Q178_9BACT
          Length = 368

 Score =  123 bits (308), Expect = 6e-27,   Method: Compositional matrix adjust.
 Identities = 79/240 (32%), Positives = 133/240 (55%), Gaps = 7/240 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTI G+D +GGAGIQAD+KT SALG    S IT++ AQNT G+Q  + +  + V  Q+++
Sbjct: 9   LTINGSDGTGGAGIQADIKTISALGGRALSAITSITAQNTLGIQEFFDLPSETVKGQIEA 68

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + +D++    K+GM+   D V  +A  L++++ ++V+ D V+++   + L++   +  +R
Sbjct: 69  IVNDIQPTVVKVGMIRRADTVAQIAHLLRQHKPKHVIYDPVIVSSQNEMLMAQEVIDEVR 128

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP  SL+     +A  L       T  ++    +SLLA GC AVL++G H   +   
Sbjct: 129 RSLLPLCSLVLMKRADAERLTQTA-INTAADLNLAVKSLLAGGCQAVLLQGSHTPPQSLT 187

Query: 187 DWLFT-REGEQRFTAPRIMTK---NT-HGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           D   T ++GE  F  P +  +   NT HG   +LSAA+A          + V  A+++++
Sbjct: 188 DVFATAKDGEPTFL-PSLFGEGEGNTRHGLSGSLSAAIATFVNGGNAIFEAVVNARNYIA 246


>UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglomus
           RepID=B5YA99_DICT6
          Length = 263

 Score =  122 bits (307), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 79/256 (30%), Positives = 124/256 (48%), Gaps = 11/256 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L IAG DPSGGAGI  D K    LG Y   + T L  QNT+ V   Y I P +     ++
Sbjct: 10  LVIAGFDPSGGAGILLDTKIIHYLGGYAFCIPTCLTVQNTQKVYKTYEINPKYFLKTFEA 69

Query: 67  VFSDV-RIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +  DV   D  KIG L    I++ +   +  Y+++N++LD V+    G PLL   A ++L
Sbjct: 70  LIKDVDYFDGVKIGALYSKKIIDLIINLIITYELKNIILDPVINPTKGKPLLKKDAFSSL 129

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAM----GCGAVLMKGGHLD 181
             +L+   S+ITPN+PE A  L     ++  +M     SLL +        +++KGGHL 
Sbjct: 130 L-QLISLCSVITPNIPE-AEFLSGIKIKSLDDM---EFSLLKIRDKFNIKNIILKGGHLA 184

Query: 182 -DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              +  D L+T +    F    +  K+ HGTGC  S+ L     ++ +      E ++  
Sbjct: 185 IGNEVYDLLYTEDKIISFKKEYLKNKHIHGTGCLFSSILTFFLAQNLSIEKAFYETENNF 244

Query: 241 SSALAQADTLEVGHGI 256
           +  + +A  +  G  +
Sbjct: 245 NKFIKRAIKISKGQYV 260


>UniRef50_A3EQ29 Phosphomethylpyrimidine kinase n=2 Tax=Leptospirillum sp. Group II
           RepID=A3EQ29_9BACT
          Length = 289

 Score =  121 bits (304), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 80/241 (33%), Positives = 118/241 (48%), Gaps = 5/241 (2%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
            +AG DPSGGAG+  DL+  SALG     + T L  QN R V+ V  +E D     LD++
Sbjct: 11  VLAGVDPSGGAGLHQDLRVLSALGVVAKGIPTCLTVQNIREVRRVVPVEEDVFREMLDAL 70

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLR 126
            +       KIG+L E  ++ ++   L        VV+D ++   SGDP L P+      
Sbjct: 71  LAVEPPALVKIGLLPEA-LLGSLRAFLDDLPCGIPVVIDPILRFGSGDPFLDPAPFQKRA 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDDEQS 185
           +R+ P+ SL+TPNLPEA+ LL        + + +    +LA  G  AV +KGGH   E  
Sbjct: 130 TRIFPRASLVTPNLPEASVLLGRDVHPDRESLRKAAEEILARYGPEAVYLKGGHASGEVK 189

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRH--TNWADTVQEAKSWLSSA 243
            D   ++      T P +     HG GCTL++ ++  R R    +W   V +A+     A
Sbjct: 190 QDLYVSQGDSLVLTYPSLAVSALHGGGCTLASLVSGCRLRSPLASWPAVVCQAREIFQKA 249

Query: 244 L 244
           L
Sbjct: 250 L 250


>UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q756M8_ASHGO
          Length = 316

 Score =  121 bits (304), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 98/270 (36%), Positives = 137/270 (50%), Gaps = 17/270 (6%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LT+AG+D SGGAGI+AD+KT +  G Y  + I+A+ AQ  R V +V       +AA L  
Sbjct: 26  LTVAGSDSSGGAGIEADIKTITMHGCYAMTCISAITAQTPRAVDAVRATPAPLLAAVLRG 85

Query: 67  VFSDVRIDTTKIGML--AETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +F D+ +D  K GML  A  D + A A R  R+    +V+D VM A SG PL   +  A 
Sbjct: 86  LFRDMAVDAIKTGMLTPAAVDCLLA-ALRDHRFA-GPLVVDPVMAASSGSPLTDLAGPAA 143

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
                  + +L+TPN+PEA  LL A    +   ++   ++L      AVL+KGGH     
Sbjct: 144 RALLR--RAALVTPNVPEACRLLAAQPPASPDGLVSLAQALARDLSTAVLLKGGHC--PY 199

Query: 185 SPDWLF-------TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            PD +           G   F A R+ T +THGTGCTL+AA+AA   R  +  + V    
Sbjct: 200 PPDAVLDVLVDPADPAGPVTFCARRLSTPHTHGTGCTLAAAIAANLSRAMSLREAVYRGI 259

Query: 238 SWLSSALAQADTLEVG--HGIGPVHHFHAW 265
            ++  A+A      V      GPVHH +A 
Sbjct: 260 IFVHHAIALQPERSVCALPENGPVHHAYAL 289


>UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii
           RepID=A5DP35_PICGU
          Length = 559

 Score =  121 bits (303), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 92/279 (32%), Positives = 147/279 (52%), Gaps = 28/279 (10%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L +AG+D SGGAGI+ADLKT SA   YG + I A+  QNT+GV+S+       +   LD+
Sbjct: 22  LVVAGSDSSGGAGIEADLKTLSAHKVYGATCIAAITVQNTQGVRSIVETSGATIRGILDA 81

Query: 67  VFSDV-RIDTT--------KIGMLAETDIVE--AVAERLQRYQIQNVVLDTVMLAKSGDP 115
           V  D  R D          K GML    + E   + + +    I+ +V+D VM++ SG  
Sbjct: 82  VMDDFGRKDVAAKSPLRAIKTGMLTPAALEELANIRDEVDSLGIK-LVVDPVMVSTSGAR 140

Query: 116 LLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM--LEQGRSLL-----AM 168
           L+S  ++A+   RL+    L+TPN  EA  L  A + +T+  +  +E+G+  +     A+
Sbjct: 141 LMSEDSMASYL-RLISGSFLVTPNYLEALELAKAVNLKTDGSINSIEEGKRFVLELRNAL 199

Query: 169 GCGAVLMKGGHL------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
            C  +L+KGGH+       + +  D+L        F +  I TK+ HG+GCTL++AL+A 
Sbjct: 200 KCDNLLVKGGHIPGFSGESERRIYDFLNQNGKLTVFESHYIDTKDNHGSGCTLASALSAH 259

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
              +    + V  A  ++  A++  + L  G G GP++H
Sbjct: 260 IALNRPVEEAVPLALDYIHHAMSNFEKL--GRGNGPLNH 296


>UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4Y2K1_CLAL4
          Length = 586

 Score =  120 bits (302), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 95/293 (32%), Positives = 147/293 (50%), Gaps = 43/293 (14%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D SGGAGI+AD+KT +A   YG + IT+L AQNT GV +V     + V A L+
Sbjct: 40  VLTIAGSDSSGGAGIEADIKTMTAHSVYGLTCITSLTAQNTLGVSAVVDTPKEHVKAILE 99

Query: 66  SVFSDVR--------IDTTKIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLAKSGDP 115
             F D          +   K GML + D VE +A  L   + + V  V+D VM++ SG  
Sbjct: 100 KNFEDFLEGYEGAPPLKVVKTGMLTK-DAVEVLASYLDYLESKKVKLVVDPVMVSTSGKI 158

Query: 116 LLSPSAVATLRSRLLPQVSLITPNLPEAAALL----DAPHARTEQEMLEQGRSLLA---- 167
           L +   +   +  ++P+  L  PN  EA  L     D P    E E ++Q ++       
Sbjct: 159 LTNDETMQLCQKTIIPRAYLCMPNYVEALHLWKCFGDEP---IEIETVDQFKTFTVRLQE 215

Query: 168 -MGCGAVLMKGGH---LDDEQSP------------DWLFTREGEQRFTAPR---IMTKNT 208
            +GC  +L+KGGH   L+ ++              D LF  + EQ+ T  R   I + N+
Sbjct: 216 KLGCANLLVKGGHIPWLNGKKFSGKDGSGQALEIVDVLFQSD-EQKVTVVRSSYIESNNS 274

Query: 209 HGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           HGTGCTL++++A+   +       V  + +++   +      ++GHG GP++H
Sbjct: 275 HGTGCTLASSVASNLAKGIPLQLAVPLSVNYIHRGMTSLKQ-KLGHGKGPLNH 326


>UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9CXT9_WOLRE
          Length = 245

 Score =  120 bits (302), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 79/245 (32%), Positives = 127/245 (51%), Gaps = 21/245 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+I  L IAG+  +GGAG+QAD+K  +  G Y  + +TAL A+NT  ++++  ++P F+
Sbjct: 1   MKKI--LIIAGSCSNGGAGLQADIKACAHFGCYSATAVTALTAENTDKIKNIVSLDPSFI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A QL  + ++   D  KIGML    I++ V   L++     VVLD V ++K G  L+  S
Sbjct: 59  ADQLGMLAAEFSFDAVKIGMLFNEPIMDVVQSFLEKNS-APVVLDPVCVSKMGHKLIKDS 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L+  L+   ++ TPNL EA  L               G     + C  ++ K  H+
Sbjct: 118 AIERLK-ELMKFAAVTTPNLREADVLF--------------GDDFTNLPCDVIVKK--HI 160

Query: 181 DDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              +S D L+ ++G  Q F  P        G GCT S++LA L  R  +    +Q+ K +
Sbjct: 161 VVGKSIDTLYRKDGSVQNFETPLADPLVIIGAGCTFSSSLACLLARGESLESAIQQGKEY 220

Query: 240 LSSAL 244
           + +A+
Sbjct: 221 IYNAI 225


>UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DPJ2_9BACT
          Length = 272

 Score =  120 bits (301), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 6/257 (2%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           + ++N  LTIAG D  G AG+QADL+ F+    +  SV++A  AQ+   V SV  +    
Sbjct: 2   INKLNTCLTIAGADSGGEAGVQADLQVFNYFNCHALSVLSATTAQSYSRVLSVNPVGITA 61

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
              QL+ VFSD +    K GML + + +    ER  +     +V+D +M++ SG  LL  
Sbjct: 62  FEDQLEVVFSDFQPACIKTGMLVDGEYINVFLER--KPSSAQLVVDPLMMSTSGTELLEK 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           SA   +R  L+P  +++TPN PE   LL        +EM+++   L+ +    V +KGGH
Sbjct: 120 SAWGVMRDLLIPSANMVTPNFPELRFLLGIDEVMCGEEMVQRYFDLVQV---PVYLKGGH 176

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             +  S D+     G        +  K +HGTGC +S+AL A      +        K +
Sbjct: 177 NAEAPSIDFFIDESGLWSLKTDELEIKASHGTGCRVSSALTAGLSNGLSGLQAAINTKKY 236

Query: 240 LSSALAQADTLEVGHGI 256
           L  +L     L  G  +
Sbjct: 237 LHQSLKSYKALSDGQYV 253


>UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria RepID=PDXK_STAES
          Length = 276

 Score =  120 bits (301), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 80/263 (30%), Positives = 131/263 (49%), Gaps = 7/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRG-VQSVYRIEPDF 59
           +K++  LTIAG+D S GAG+QADLKTF  L  YG   +T++V  +       V  I+ + 
Sbjct: 3   LKKV--LTIAGSDTSAGAGMQADLKTFQELDVYGMVALTSIVTMDKETWSHDVTPIDMNV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
              QL++  S +  D  K GML   DI++   +          V+D VM+ K  D +L+P
Sbjct: 61  FEKQLETAIS-IGPDAIKTGMLGTQDIIKRAGDVFVESGADYFVVDPVMVCKGEDEVLNP 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
                +   LLP+ +++TPNL EA  L       + ++M +  + +   G   V++KGG 
Sbjct: 120 GNTEAMIQYLLPKATVVTPNLFEAGQLSGLGKLTSIEDMKKAAQVIYDKGTPHVIIKGGK 179

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            LD ++S D  +  +   + T         HG GCT +AA  A      +  + +  AK+
Sbjct: 180 ALDQDKSYDLYYDGQQFYQLTTDMFQQSYNHGAGCTFAAATTAYLANGKSPKEAIIAAKA 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           +++SA+      ++   +GPV H
Sbjct: 240 FVASAIKNG--WKMNDFVGPVDH 260


>UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) n=1
           Tax=Archaeoglobus fulgidus RepID=O28075_ARCFU
          Length = 243

 Score =  120 bits (301), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 84/247 (34%), Positives = 126/247 (51%), Gaps = 16/247 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK I  LTI+G DPSGGAG+ AD+KT  A+G Y  SVIT+L  QNT GV++   +E + +
Sbjct: 1   MKTI--LTISGLDPSGGAGVSADIKTAKAIGLYPASVITSLTVQNTCGVKAAIPVEAEVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL +V  D++ID  KIG++   +I + +A  L        VLD V+ A +G  +    
Sbjct: 59  REQLRAVIEDMKIDCIKIGLITSVEIAKVLAAELVPLNAPK-VLDPVIFAGAGGKIGDEE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A       +L  V ++TPNL EA  LL++     E   LE  +     GC  V++ GG L
Sbjct: 118 A----YKMILKHVDIVTPNLTEAITLLESTKEAREL-ALEMNKK---YGCD-VVITGGEL 168

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +     +    G     +      N HGTGC  S ALA       +  + V++A+ ++
Sbjct: 169 GGKD----VVCEAGRTYTVSAEFSPVNIHGTGCVYSTALACYLGLGNSLENAVRKARIFV 224

Query: 241 SSALAQA 247
             ++ +A
Sbjct: 225 LESVKKA 231


>UniRef50_C9MT59 Thiamine-phosphate pyrophosphorylase/phosphomethylpyrimidine kinase
           n=5 Tax=Prevotella RepID=C9MT59_9BACT
          Length = 363

 Score =  120 bits (300), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 64/244 (26%), Positives = 122/244 (50%), Gaps = 30/244 (12%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTI G+D +GG+G+QAD++T +ALG Y  S +T++  QNT G+Q+ Y +  D V  Q+++
Sbjct: 43  LTITGSDSTGGSGVQADIRTIAALGGYAVSAVTSITVQNTVGIQAFYDLPADIVKGQIEA 102

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + +D++ DT KIGM+  T+ +  + E L +Y+  +++ D ++ A +GD L++   +  +R
Sbjct: 103 IINDMQPDTVKIGMIRTTETLAVIVEALSKYRPHHIIYDPIVTASNGDRLMTDDVIMQIR 162

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            RLLP  S++     +A  + +    +                           D E + 
Sbjct: 163 HRLLPLCSMVILRESDAERIFNCTSLQ---------------------------DSETTA 195

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
                ++G +      ++    HG   + S+ALA    +     D ++ AK ++ + +A+
Sbjct: 196 SLSANKQGVRSLVLDEVL---QHGLSNSFSSALAVYLSQDETMEDAIKHAKEYIRTLVAR 252

Query: 247 ADTL 250
              L
Sbjct: 253 KSDL 256


>UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobacterium modesticaldum
           Ice1 RepID=B0TDW0_HELMI
          Length = 290

 Score =  119 bits (299), Expect = 8e-26,   Method: Compositional matrix adjust.
 Identities = 79/237 (33%), Positives = 118/237 (49%), Gaps = 26/237 (10%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    +TIAG+DPSGGAGIQADLK  +  G YG + +TAL  Q + GV  ++ +   +V
Sbjct: 1   MKLPKVVTIAGSDPSGGAGIQADLKVLAQFGVYGGAAVTALTRQTSAGVLGLFPLPAAWV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAE----RLQRYQ------------------ 98
             Q+  V  D+R    K GML +  ++  +       LQ Y+                  
Sbjct: 61  LEQISDVLWDLRPPVVKTGMLQQPAVISGLGRLWGAYLQEYRDTAAQVLPPASSTTPAPT 120

Query: 99  IQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM 158
           +  +V+D V+ + +G  L+    +A  R  LLP  +++TPN+PEA AL      R   +M
Sbjct: 121 LPILVVDPVLSSGAGVSLVDGGGLAAFREDLLPVTTVLTPNVPEAEALTGM-AIRDSGDM 179

Query: 159 LEQGRSLLAMGCGAVLMKGGHL---DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTG 212
           +     LL  G   VL+KGGHL   + ++  D L +RE  +     R+   + HGTG
Sbjct: 180 IGAAERLLQFGPQWVLLKGGHLPEWEGDRIADLLISREERRWLWGQRVPRADLHGTG 236


>UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales RepID=A2BMS2_HYPBU
          Length = 475

 Score =  119 bits (297), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 95/256 (37%), Positives = 136/256 (53%), Gaps = 7/256 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+T+AG DPSGGAGI ADLK F+A+G +G  V+  +  Q+TRGV+ V+ +    V  QL 
Sbjct: 21  AVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQLQ 80

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D R+   K G+L   + VEA+A RL R +   +V+D V  A +G  L S  A   +
Sbjct: 81  AVLEDYRVGAVKTGVLGSRENVEAIA-RLLRGRDIALVVDPVYRASAGQLLNSDDAFKAI 139

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDDEQ 184
              L P  SL+ PN+PEA   +     R+ ++     R L+   G  A L+KGGHL  E 
Sbjct: 140 VEELFPLASLVAPNVPEAER-ITGTRIRSIEDAKRAARILVEDYGARAALIKGGHLPGEP 198

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             D L+  +    F   R  +  +HGTGCT +AALAA   +  +  + V  A+  +  A+
Sbjct: 199 V-DVLYYEDVFWEFRGER-RSGCSHGTGCTFTAALAAGLAKGLDLVEAVVRARKLVEEAI 256

Query: 245 AQADTLEVGHGIGPVH 260
                  VG G  PV+
Sbjct: 257 EYG--FRVGRGDCPVN 270


>UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax=Plasmodium
           RepID=B3L660_PLAKH
          Length = 329

 Score =  118 bits (296), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 46/289 (15%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L+IAG+D  GGAGIQAD+KT   LG + C+ +  L AQNT+ V+ +  IE  F+  QL
Sbjct: 6   NILSIAGSDSCGGAGIQADIKTAMGLGCHCCTALVVLTAQNTKEVKRIVEIEEAFIVDQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERL-----QRYQIQNVVLDTVMLAKSGDPLLSP 119
           DS+F+DV ID  K+G+L    I+  V++ +     +R +   VV D V ++ SG  L+  
Sbjct: 66  DSIFADVTIDVVKLGVLYSKKIISLVSQYIVQMNKKRGKKLLVVFDPVFVSSSGCLLVEN 125

Query: 120 SAVATLRSRLLPQVS-LITPNLPEAAALLDAPHAR---TEQEMLEQGRSLLAM-GCGAVL 174
                    L+  +S +ITPN  E   +L A   +   ++  M E  + +  M    A L
Sbjct: 126 LEYIKFALDLICPISCIITPNFYECKVILQALDCQMDLSKANMTELCKLVTRMLDINACL 185

Query: 175 MKGGHLDDEQSP-------DWLFTR------EGE--QR----------------FTAPRI 203
           +K  ++ +  +        D L  R      EGE  QR                +   ++
Sbjct: 186 LKSCNVGENSAEENEVYAVDHLCIRKVGSIPEGEVIQRDAGELGQSAPGGVTYLYDVYKL 245

Query: 204 MTK-----NTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
            +K     + HGTGCTLS A+A    +  N   +  E+K ++ + +  A
Sbjct: 246 RSKRKPGVDVHGTGCTLSTAIACYLAKKHNILQSCIESKKYIYNCIRYA 294


>UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobus solfataricus
           RepID=D0KR61_SULS9
          Length = 400

 Score =  118 bits (295), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 76/220 (34%), Positives = 118/220 (53%), Gaps = 9/220 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLKTFSALG +G ++IT L AQNTR V  V  I  DF+ AQ D+V  D+     K G
Sbjct: 21  LQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA   +VE V  +++ Y I+ +VLD VM+AKSG  L++      ++ + + +  + TPN
Sbjct: 81  MLASGKVVELVLRKIREYNIK-LVLDPVMVAKSGSLLVTEDISEQIK-KAMKEAIISTPN 138

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
             E A +++     ++ ++++  R + +   G V++KG +       D+      E    
Sbjct: 139 RYE-AEIINKTKINSQDDVIKAAREIYS-KYGNVVVKGFN-----GVDYAIIDGEEIELK 191

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              I TKNTHG+G   SA++ A         D +  AK +
Sbjct: 192 GDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKF 231


>UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RU47_CENSY
          Length = 438

 Score =  117 bits (294), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 87/259 (33%), Positives = 125/259 (48%), Gaps = 15/259 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LT+AG+DPS GAGIQ DL T S +G  G SVITA+ AQN+ G      +    VA Q+ +
Sbjct: 10  LTVAGSDPSSGAGIQGDLGTISRMGCTGLSVITAITAQNSSGFTGAEPVPTSMVALQMQA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V SD  +   K+GM+    ++ AV+  L+   +  VVLD VM + +G  LL  +A+  L 
Sbjct: 70  VLSDYDVSAVKVGMVLTVPVIRAVSRGLEELDVP-VVLDPVMHSTTGGRLLDDAALPALS 128

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG----GHLDD 182
             L+ +  ++TPN  E  A+L    A T  +       LL  G GAV + G    G + D
Sbjct: 129 KHLVSRADVVTPNASE-LAVLSGMKAGTAVQARTAATKLLDRGAGAVAVTGLAGRGKIYD 187

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +           E    + R +   +HG GC  SAA+AA   R        +EA      
Sbjct: 188 Q------VVTSKEHFEVSGRRIRGESHGGGCAYSAAMAASLARGMGLKAAAREAAEHSRR 241

Query: 243 ALAQADTLEVGHGIGPVHH 261
           ++A   +   G G+  V H
Sbjct: 242 SIASTRS---GRGLPTVSH 257


>UniRef50_C4LKS0 Phosphomethylpyrimidine kinase n=1 Tax=Corynebacterium
           kroppenstedtii DSM 44385 RepID=C4LKS0_CORK4
          Length = 381

 Score =  117 bits (294), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 70/144 (48%), Positives = 84/144 (58%), Gaps = 2/144 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D SGGAGIQADLKT SALG YGC  ITA+ AQNTRGV +   + P+FVA Q+ S
Sbjct: 12  LTIAGSDSSGGAGIQADLKTISALGGYGCVAITAVTAQNTRGVDAAEYMSPEFVAQQIRS 71

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPSAVATL 125
           V  D  ID  KIGM+  + I +A+   L        VV D VM+A SG  L+     AT 
Sbjct: 72  VADDYPIDAIKIGMVGSSSIADAIVAELTALSFAGPVVWDPVMVASSGSSLVDDETTATS 131

Query: 126 R-SRLLPQVSLITPNLPEAAALLD 148
               L  +   +TPN  E   L D
Sbjct: 132 GFVDLARRADALTPNGRELVGLCD 155



 Score = 48.5 bits (114), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 30/83 (36%), Positives = 38/83 (45%), Gaps = 18/83 (21%)

Query: 192 REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT------------------V 233
           RE     +  R+ T NTHGTGCT S+ALA    R  + ADT                  V
Sbjct: 271 REQTALLSHDRVATTNTHGTGCTFSSALATFAARRVHQADTSADPDSHPGVSACDWRAAV 330

Query: 234 QEAKSWLSSALAQADTLEVGHGI 256
            +A +W   AL  ADTL+   G+
Sbjct: 331 HDAATWTRRALVAADTLDFAIGL 353


>UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepID=Q6FDT4_ACIAD
          Length = 259

 Score =  117 bits (293), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 85/253 (33%), Positives = 128/253 (50%), Gaps = 19/253 (7%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L  +G DPSGGAG+QAD+++    GA+     TAL  QN++ V        + + A
Sbjct: 2   RPTVLCFSGLDPSGGAGLQADIESIGQSGAHAAIACTALTIQNSQQVFGFEATSKELLLA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++V  D+ I   K GML  T+ + A+A+ L+ +     VLD V++A SG  L   + +
Sbjct: 62  QANAVVVDLPIKCVKSGMLGTTENIAALAQFLREHPDYQYVLDPVLVANSGGSLGDQATL 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAAL--LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
                 L+P  ++ITPN  E  AL  LD     T++        L  MG  A+L+KGGH 
Sbjct: 122 VKAFVELIPLATVITPNTVELRALTGLDNIEDATQK--------LFDMGAQAILVKGGH- 172

Query: 181 DDEQSPDWLFTR---EGE--QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
             E +PD +  +   +GE     T PR +    HG+GC+L++ +A       +    VQ 
Sbjct: 173 --EATPDHIHNQLFIKGELVAESTCPR-LEGEYHGSGCSLASYIAGRLALGDDLKIAVQH 229

Query: 236 AKSWLSSALAQAD 248
           A+ WL   L QA+
Sbjct: 230 AEVWLFDVLKQAE 242


>UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DKQ9_LACTC
          Length = 570

 Score =  117 bits (293), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 89/279 (31%), Positives = 142/279 (50%), Gaps = 29/279 (10%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +T+A +DPSGGAGI+ADLKTF+A   YG + + AL AQ   GV +++ I  +     LDS
Sbjct: 34  MTVATSDPSGGAGIEADLKTFTAHRCYGLTGMAALTAQTPEGVYAIHEIPKEHFKLTLDS 93

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ---NVVLDTVMLAKSGDPLLSPSAVA 123
              D+R+D  K GML +   VE + E           ++V+D V++A SG  L+S  +V 
Sbjct: 94  CLRDMRVDAIKTGMLTKP-AVEVLYETFSAMPADARPHLVVDPVLVATSGSTLVSDQSVI 152

Query: 124 TLRSRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMG-CGAVLMKGGHL 180
                L P  +L+TPN  EA  +L  ++    + +++++    L     C  VL+KGGH 
Sbjct: 153 DFIKTLSPLATLLTPNAYEAGRILGRESLELNSVEDLIDVACELQKTTLCPNVLLKGGH- 211

Query: 181 DDEQSPDWLFTREGEQRFT-------------APRIMTKNTHGTGCTLSAALAALRPRHT 227
               +P W+    G++R T             +    ++NTHGTGCTL++A+A+      
Sbjct: 212 ----AP-WV-DSNGQKRVTDVLRLGNKTVLYRSVFCTSENTHGTGCTLASAIASNLAHGE 265

Query: 228 NWADTVQEAKSWLSSALAQADTLEVGH--GIGPVHHFHA 264
                V     ++ +A+    T+   H    GP++H +A
Sbjct: 266 ALQHAVFGGIQYVHNAIEIGCTVTQPHVKKNGPINHVYA 304


>UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella chejuensis KCTC
           2396 RepID=Q2SQL4_HAHCH
          Length = 487

 Score =  117 bits (292), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 89/252 (35%), Positives = 133/252 (52%), Gaps = 8/252 (3%)

Query: 9   IAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVF 68
           IA +D +G +GIQADL T   L  +G   +TA+ AQN++ V S+  +    +  QL ++ 
Sbjct: 11  IAASDSAGASGIQADLATLRGLEVHGGVALTAVTAQNSQEVLSINPVATAVLRDQLRALR 70

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSR 128
           +D      KIG+L + + V+ + E L  Y    VVLD V+ + +G       +VA L+S 
Sbjct: 71  ADGDAVAIKIGLLTDAEQVDVLREFLCAYS-GLVVLDPVLGSSTGAGF--GMSVAALKS- 126

Query: 129 LLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-DEQSPD 187
           LLP V ++TPN+PEA  L D     +  +ML     L  +G   V +KGGHL   EQ  D
Sbjct: 127 LLPYVDVVTPNIPEAEQLADR-RISSPADMLSAAVRLRELGAKGVWLKGGHLGLGEQCLD 185

Query: 188 WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
            ++  E    F  PR+  ++  GTGCTL++ALAA   R  +  D    A +++   L Q 
Sbjct: 186 LVWLSEQPYWFAQPRLSVRHHRGTGCTLASALAAFVARGESLLDAAALANAYVKQGLRQG 245

Query: 248 DTLEVGHGIGPV 259
               +G G GP+
Sbjct: 246 --YAIGPGPGPI 255


>UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G3W4_PHATR
          Length = 580

 Score =  116 bits (291), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 96/284 (33%), Positives = 143/284 (50%), Gaps = 46/284 (16%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADL    + G +GCS IT L AQN+ GV  V+   PDF+ AQL+++  D+     KI
Sbjct: 52  GIQADLHAIHSFGCHGCSAITCLTAQNSVGVIGVHAPPPDFLRAQLETLLEDLPPQAIKI 111

Query: 79  GMLAETDIVEAVAERLQRYQIQN----VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           GML   ++   V   L++ +  +    VVLD VM+  SG  L+   A   +   + P + 
Sbjct: 112 GMLGTKELAIEVGAFLKKLKALDRKVWVVLDPVMITTSGHRLIEEDAQEAMVKHVFPHID 171

Query: 135 LITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE---------QS 185
           ++TPN  EA ALL+     T  ++ E  + L+A+G  +VL+KGGH   E          +
Sbjct: 172 VLTPNKFEAEALLNRT-LETISDVEEGAKDLIALGAPSVLIKGGHTLYEGGKASNHIAYA 230

Query: 186 PDWLFT----REGEQRFT---------APRIMTKNTHGTGCTLSAALAAL---------- 222
            D+  +      GE R           +PR  T++THGTGCTLSA+LAA           
Sbjct: 231 QDYFLSSVQRNTGEPRLCDGDLGVWLRSPRYETEHTHGTGCTLSASLAASLALGEQERQK 290

Query: 223 ----RPRHTNWADTVQE---AKSWLSSALAQADTLEVGHGIGPV 259
               R   T+  DTV     AK+++++ +     +++G G GPV
Sbjct: 291 PDGKRRGATSAIDTVDACCLAKAYVTAGIFHG--IQLGQGPGPV 332


>UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=6 Tax=Coxiella burnetii
           RepID=A9NB66_COXBR
          Length = 479

 Score =  116 bits (291), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 76/239 (31%), Positives = 119/239 (49%), Gaps = 2/239 (0%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           +I G+D SGGAG QAD+ T      +  S+IT + AQN   V  +   + D +  Q+ ++
Sbjct: 9   SIGGSDCSGGAGCQADILTCRDFNVHAASIITTITAQNAEQVLKINYCDSDLIQKQIQAL 68

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
              +     K+G+L   +IV AVA  L+ Y    VV D V+ + SG  L +   +  L+ 
Sbjct: 69  KETLPPTVIKLGLLGTKEIVTAVASYLKNYS-GKVVCDPVLNSTSGVLLHASDYLDLLKK 127

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPD 187
            L P V L+TPN+PEA  L+      T  +++     LL  G  AVL+KGGHL   ++ D
Sbjct: 128 LLFPHVDLLTPNIPEAEILIQN-KIHTFSDIISAAHQLLKCGVSAVLLKGGHLIGSKACD 186

Query: 188 WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           +    + E      +I      GTGC LS+A+++      +  D +  AK ++   + Q
Sbjct: 187 FFTDGKCEFWLAHTKIPKTRVRGTGCALSSAISSAIALGYSLKDAIVVAKMYVQQGIRQ 245


>UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Tax=Proteobacteria
           RepID=Q48DP3_PSE14
          Length = 304

 Score =  116 bits (290), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 81/254 (31%), Positives = 128/254 (50%), Gaps = 5/254 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L ++G DPSGGAG+QAD++   A G +    ITAL  Q+T  V     ++ ++V A
Sbjct: 46  RPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPAITALTVQDTVNVSDFRVLDREWVMA 105

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++V +D  +   K+GML   ++V+ V + L  +    +V D V+ A  G  L      
Sbjct: 106 QANAVLNDSNVAAVKLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEVG 165

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +R RLLP  ++ TPNLPEA  L + P   T  E  ++    L + C  +L+ GGH D+
Sbjct: 166 YAMRERLLPLSTIATPNLPEARILAELPEG-TADECADK----LLLFCEYLLITGGHGDE 220

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +Q  + L+ R  +        +  + HG+GCTL++ALA    +       V+ A  +   
Sbjct: 221 QQIHNRLYVRGAQTHTFICERLPGSYHGSGCTLASALAGRIAQGEELVSAVRSALDYTWR 280

Query: 243 ALAQADTLEVGHGI 256
            L  A+ L  G  +
Sbjct: 281 TLRDAEQLGRGQFV 294


>UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) n=1
           Tax=Thalassiosira pseudonana RepID=B8C466_THAPS
          Length = 265

 Score =  116 bits (290), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 89/271 (32%), Positives = 136/271 (50%), Gaps = 49/271 (18%)

Query: 20  IQADLK---TFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTT 76
           IQADLK   T S    +GCS IT L AQN+ GV SV+     F+  QL+ +  D+     
Sbjct: 13  IQADLKAIHTLSNGACHGCSAITCLTAQNSCGVTSVHSPPVAFLREQLNVLEGDLYPKAV 72

Query: 77  KIGMLAETDIVEAVAERLQRYQIQN---------VVLDTVMLAKSGDPLLSPSAVATLRS 127
           K+GML   ++ E V   L++ + ++         VV+D VM++ SG  L+  +A   +  
Sbjct: 73  KVGMLGSGELAEEVGGWLRQLKEKHSGDGGVMPLVVVDPVMISTSGHKLVDDTAKKAMIE 132

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-------- 179
           ++ P   L+TPN  EA  LL      T  ++ E    +LAMG  AVL+KGGH        
Sbjct: 133 KVFPFADLVTPNKFEAEELL-GRKLLTPSDVKEGAAEILAMGAKAVLIKGGHSLMETQRV 191

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWA--------- 230
           +D+++   W+ +          R  T +THGTGCTLS+A+A      T WA         
Sbjct: 192 VDEKEDGIWIRSE---------RYETSHTHGTGCTLSSAIA------TAWAMGQPLSAMH 236

Query: 231 --DTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             D    AK++++  +++   +++G G GPV
Sbjct: 237 LVDACCIAKAYVNDGISKG--VQLGKGPGPV 265


>UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Saccharomycetaceae
           RepID=THI22_YEAST
          Length = 572

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 80/270 (29%), Positives = 140/270 (51%), Gaps = 13/270 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           ++IAG+D SGGAG++AD+KT +A   Y  + +T L AQ    V   + I    V+  LD+
Sbjct: 49  MSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAHNIPKKMVSQILDA 108

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRY--QIQNVVLDTVMLAKSGDPLLSPSAVAT 124
              D++ +  K GML   D +E + E+L +       +V+D V+ A S         V+ 
Sbjct: 109 NLQDMKCNVIKTGMLT-VDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPTGKDVVSL 167

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTE-QEMLEQGRSLLAM-GCGAVLMKGGHL-- 180
           +  ++ P   ++TPN+ +   LL      ++ Q++LE  + L  +  C  +L+KGGH+  
Sbjct: 168 IIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNILVKGGHIPC 227

Query: 181 DD--EQSPDWLFTREGEQRFTAPR---IMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           DD  E+    +     EQ+F   +   + T  THG GCTL++A+A+   R  + + +V  
Sbjct: 228 DDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLARGYSLSQSVYG 287

Query: 236 AKSWLSSALA-QADTLEVGHGIGPVHHFHA 264
              ++ +A+A   D  +    +GP++H +A
Sbjct: 288 GIEYVQNAIAIGCDVTKKAVKVGPINHVYA 317


>UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 Tax=Aciduliprofundum
           boonei T469 RepID=B5IAY3_9EURY
          Length = 242

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 77/241 (31%), Positives = 119/241 (49%), Gaps = 13/241 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DP+ GAG+  D+ TF   G YG  V TAL  QNTRG +    + P+ V  +L +
Sbjct: 5   LSIAGFDPTSGAGVIRDIITFRKFGFYGLGVATALTYQNTRGFKGFKVLSPNVVEQELKA 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D  I   K+GML  +  V+ + E   R     ++ D ++ AK+G  +     +    
Sbjct: 65  IMGDFPIKFVKVGMLGTS--VDLIVE-FAREHDWFLIFDPLLTAKNGKTINKIEDIEP-- 119

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL     ITPN+PEA   L     + E +++  G+ L       V++KGGHL+     
Sbjct: 120 --LLKIAEAITPNVPEAEK-LAGIKIKNESDVISAGKILTHKYGKYVIIKGGHLNGR--- 173

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D+LF  E  + +  P+I  K  HGTGC  S++L +   +     +   EA+ +L   +  
Sbjct: 174 DYLFGDE-IKSYGMPKI-NKIVHGTGCAYSSSLLSFIAKGLKIEEAFIEARKFLQREIEN 231

Query: 247 A 247
           A
Sbjct: 232 A 232


>UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQ01_9BURK
          Length = 277

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 81/216 (37%), Positives = 113/216 (52%), Gaps = 9/216 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LT + +DP+ GAG+QAD  T SALGA+  +++T L AQNT GV       PD++  QL +
Sbjct: 9   LTFSASDPTAGAGLQADALTVSALGAHPLTILTGLTAQNTAGVARFEACTPDWIDDQLTA 68

Query: 67  VFSD-VRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +  D +     K G+L  T  V AV +    +    +V+D V  +  GD           
Sbjct: 69  LLDDGISPSAIKTGVLGSTAAVAAVLKAKSLWPSVPLVVDPVRASGRGDAFGGQGLFDYY 128

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R++L P V L+TPN PEA A   A      Q + E G  LL MGC AVL+KG HL+    
Sbjct: 129 RNQLFPAVDLLTPNWPEAQAFTGA------QTVDEAGERLLKMGCKAVLLKGEHLESGDI 182

Query: 186 PDWLFTREGEQRFTAP-RIMTKNTHGTGCTLSAALA 220
            + L+ R G+     P   +    HG+GCTL++A A
Sbjct: 183 VNRLY-RPGQPVVEFPCERLPGQYHGSGCTLASACA 217


>UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosphate kinase) (HMP-P
           kinase) n=7 Tax=Saccharomycetales RepID=A3LN87_PICST
          Length = 583

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 94/299 (31%), Positives = 144/299 (48%), Gaps = 45/299 (15%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D SGGAGI+ADLKTFSA   YG + I AL AQNT+ V++  +   + V   L 
Sbjct: 23  VLTIAGSDNSGGAGIEADLKTFSAHKVYGLTCIAALTAQNTQLVKTFEKTPKELVKNILQ 82

Query: 66  SVFSDVRI---DTT------KIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLAKSGD 114
             F D      D+T      K GML E + V  + + L   +  NV  ++D VM++ SG 
Sbjct: 83  LNFDDFLYGYEDSTQPLKVIKTGMLTE-EAVHVIQDFLPDIKKHNVKLIVDPVMISTSGS 141

Query: 115 PLLSPSAVATLRSRLLPQVSLITPNLPEAAALLD---APHARTEQEMLEQGRSLL----- 166
            L     +    + L+    LITPN  EA AL +      A  E+  +      +     
Sbjct: 142 SLFDSEGMKLCVNTLISGAYLITPNFVEARALWEIACGESAAIEKLTINSLDDFIDFVKQ 201

Query: 167 ---AMGCGAVLMKGGHL----------------DDEQSP---DWLFTREGEQR--FTAPR 202
               +    VL+KGGH+                D E S    D L+  E ++   F +  
Sbjct: 202 LQKTLKSQNVLVKGGHIPWDSRTGKPFVGTNLADVEDSIVVLDVLYESEIDKATVFESKY 261

Query: 203 IMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           I TK++HGTGCTL++A++A   +  N  +++  +  ++   +      ++G+G GP++H
Sbjct: 262 INTKDSHGTGCTLASAISANVAKGKNLKESISLSIDYIHKGMLSVGK-KLGYGNGPLNH 319


>UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=1 Tax=Francisella philomiragia
           subsp. philomiragia ATCC 25017 RepID=B0TY65_FRAP2
          Length = 485

 Score =  115 bits (288), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 75/252 (29%), Positives = 137/252 (54%), Gaps = 5/252 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTI G+D S GAGIQAD+KT + +G + C++I+ + AQN+  + ++ ++       Q+ +
Sbjct: 6   LTIGGSDSSSGAGIQADIKTANNIGVHACTIISCVTAQNSTNILNIEKVSKGIFKEQIQA 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  + +I   K  +L+ T+ ++ V + L   +    + D VM++ +G  L+    V   +
Sbjct: 66  ISKEFKIKVIKTSVLSSTEQIDIVVDLLNDLKDVFYICDPVMVSTTGYSLVDYRLVEYSK 125

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLDDEQ- 184
            +L P  +++ PNL EA  LLD  H     E+ E  +++     C +VL+KGGH  D+  
Sbjct: 126 QKLYPLANILVPNLDEAKMLLD-EHDSPNVEIAEIAKAIQEKYNCKSVLLKGGHDSDKNI 184

Query: 185 SPDWLFTREGEQRFTAPRI-MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           S D  +T E     T+ R  + +   GTGCT ++A+A+      +  +++  AKS++S+A
Sbjct: 185 SLDCYYTPEVNYTLTSKRYKLDEKVRGTGCTFASAIASFLTLGFDVNNSIILAKSYISNA 244

Query: 244 LAQADTLEVGHG 255
           +  +  +   HG
Sbjct: 245 IKSSQKI-ASHG 255


>UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=A7GXD3_CAMC5
          Length = 244

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 79/262 (30%), Positives = 130/262 (49%), Gaps = 29/262 (11%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L IAG+D +GGAG QAD+KT  A G Y  + IT  V +NT+    +  +    V +Q+
Sbjct: 3   NILIIAGSDSAGGAGAQADIKTCEAFGCYSATAITVFVCENTQVTYDISSVPASCVDSQI 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
             +  +++ID  KIGML +   ++ V + L ++ +  +V+D V ++KS   L+   A+  
Sbjct: 63  RGITEELKIDAVKIGMLFDVQTIKVVEKWLPKFNVP-IVIDPVCISKSNVKLIKDDAIDA 121

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           LR  +L   ++ TPN  EA AL                    ++ C  ++ K  H+ + +
Sbjct: 122 LRG-ILKFATIATPNRYEAQALFH--------------NDFSSLVCDVIVKK--HVVNGE 164

Query: 185 SPDWLFTREGEQRFTA-----PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           S D L  ++G Q   A     P IM    HG GCT S A+A    +  +  ++V +AK++
Sbjct: 165 SIDTLHKKDGSQLNFATALADPFIM----HGAGCTFSTAIACCLAQGLSLEESVTKAKNY 220

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+     LE   G   ++H
Sbjct: 221 VYQAIKTG--LETKFGKTLLNH 240


>UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptococcaceae
           RepID=A2RIH2_LACLM
          Length = 262

 Score =  114 bits (285), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 75/254 (29%), Positives = 138/254 (54%), Gaps = 16/254 (6%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+D   G G+QADL TF+A G YG   +T++V         V+ ++ +    +L+S
Sbjct: 12  LTIAGSDILSGGGMQADLATFAANGLYGFCALTSIVTVKEDKF-FVHPVDEEIFQEELES 70

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN---VVLDTVMLAKSGDPLLSPSAVA 123
           + +D+     KIG+L    I+E   + L    +++   ++LD V++ K      +  +V+
Sbjct: 71  L-TDIDFSAIKIGLLPNKKILEMTKKWLTALSVKSPVPIILDPVIVFKEN----ADYSVS 125

Query: 124 TLR----SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            +R    S+L P  ++ITPNL E A +L     +TE +M    + L   G   V++KGG+
Sbjct: 126 EMRELFISQLFPLATVITPNLKE-AEILTGLSVKTEADMKAAAKLLHRFGAKNVIIKGGN 184

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
             D +Q+ D+ +  +   +  +P ++ KN +G GCT ++++A+      ++ D+V++AK 
Sbjct: 185 RFDQKQAIDFAYDGKDFYQLASP-LLQKNNNGAGCTFASSIASQMAEENSFKDSVEKAKD 243

Query: 239 WLSSALAQADTLEV 252
           ++  A+  A+   V
Sbjct: 244 FVYQAIQNANEFGV 257


>UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SEE1_CHRVI
          Length = 272

 Score =  113 bits (283), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 86/250 (34%), Positives = 129/250 (51%), Gaps = 19/250 (7%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L + G DPSGGAGI AD +   A  A+  +VITAL  Q+T G+  ++   P+ + A    
Sbjct: 13  LCVGGHDPSGGAGILADAEVVQAARAFPLTVITALTEQDTCGLAQIHPQPPEQIEAHCRR 72

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERL------QRYQIQNVVLDTVMLAKSGDPLLSPS 120
           + SD      KIG++   DI   +A  +      +R ++  VVLDTV+   +G  +   +
Sbjct: 73  LLSDSPPSALKIGLIGGADIARMLARFIDTLATAERARVP-VVLDTVLATGAGQSVADAA 131

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
               +R  L+P+ +L+TPNLPEA AL   DAP    E+        LLA G   VL+ G 
Sbjct: 132 LREAVREALIPRCTLVTPNLPEARALTGADAPEDCAER--------LLAAGAPWVLITGT 183

Query: 179 HLDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H   E   + LF   GE+  +  PR +    HG+GCTL++A+AA           V+ A+
Sbjct: 184 HDATEAVTNRLFGSNGERHAWDWPR-LPGEYHGSGCTLASAIAARLAHGMTLIQAVESAQ 242

Query: 238 SWLSSALAQA 247
           ++  +AL +A
Sbjct: 243 AYTWTALERA 252


>UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kangiella koreensis
           DSM 16069 RepID=C7R6N5_KANKD
          Length = 493

 Score =  113 bits (283), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 74/215 (34%), Positives = 120/215 (55%), Gaps = 5/215 (2%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           + AG D SG AG  AD++T  ALGA+ C V TAL AQN++ V ++     + + +QL+++
Sbjct: 11  SYAGLDNSGMAGQVADIRTIEALGAHACCVTTALTAQNSQRVVAINPSAKEQLQSQLEAL 70

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQ--IQNVVLDTVMLAKSGDPLLSPSAVATL 125
               + +  K+G+L   + ++ +   L++    IQ +V D V+ + SG   + P  V   
Sbjct: 71  QELGQPNAIKVGLLPSEESIQLLITYLEKASNPIQ-LVFDPVIESSSGTQFM-PDEVLEQ 128

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
             +LLP V++ TPN+ E A  +     ++  ++  Q + LL  G  AVL+KGGH   EQ+
Sbjct: 129 LEKLLPLVTVFTPNIDELAR-ITGQKIQSIDDIESQAKKLLESGTSAVLVKGGHWPSEQA 187

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALA 220
            D+   R+ +    + R  T NT GTGC LS+A+A
Sbjct: 188 SDFFVNRQHQFWLHSDRQETDNTRGTGCVLSSAIA 222


>UniRef50_B8CNV7 Phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase,
           putative n=1 Tax=Shewanella piezotolerans WP3
           RepID=B8CNV7_SHEPW
          Length = 527

 Score =  113 bits (283), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 90/250 (36%), Positives = 129/250 (51%), Gaps = 25/250 (10%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADL T + L A+GCSVITA+ AQ++  V SV  + P  + AQLD + +D+     KIG
Sbjct: 31  IQADLATINDLDAHGCSVITAVTAQSSVTVASVEAVSPQILIAQLDVLTADLAPQAIKIG 90

Query: 80  MLAETDIVEAVAERLQRYQIQ--------NVVLDTVMLAKSGDPLLSPSAVATLRSRLLP 131
           +LA    +  VA  L +  +Q         V+LD VM+A  GD L    A+     + L 
Sbjct: 91  LLANQQQINLVANWLHKILLQWRERGLTVAVILDPVMVATCGDALTGSEALDFTPFKGL- 149

Query: 132 QVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL----DDEQSPD 187
            ++LITPN+ E A L        EQ + +  ++L A    +V+ KGG +    D+  + D
Sbjct: 150 -LTLITPNVTELATLAGRQLITPEQSV-QAAQTLAAQLQVSVIAKGGDIGPNWDEGLARD 207

Query: 188 WLFTRE--------GEQRF--TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            L   +         E  F  T+ RI T N HGTGCTLS+A+AA+        D V  AK
Sbjct: 208 LLVCHQVTGISSLHSEHAFWLTSNRINTNNNHGTGCTLSSAIAAVMAHGFVLNDAVVVAK 267

Query: 238 SWLSSALAQA 247
           +++S  L Q+
Sbjct: 268 AYVSQGLVQS 277


>UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4N3_9GAMM
          Length = 252

 Score =  113 bits (283), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 68/219 (31%), Positives = 120/219 (54%), Gaps = 11/219 (5%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           + L ++G DP GGAGI AD++T +  G     +IT L  QNT+ V+S   ++   +A Q 
Sbjct: 4   SVLVLSGLDPCGGAGIAADIETINQFGVTPLPIITTLTVQNTQSVKSTQEVDSKLIAEQF 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           + + +DV     KIG+L+    +E +   L       +VLD ++ + + D LL    +  
Sbjct: 64  NHLKTDVTFSVAKIGLLSSKKQIEVLTNLLSECDDVTIVLDPIVKSTAKDKLLDSQTLEV 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L+++LLP V +ITPN+ E  AL  +P+ + EQ+ +E      ++ C  VL+      +++
Sbjct: 124 LKTKLLPLVDVITPNVDELQAL--SPN-KNEQQAVE------SLPCEWVLLTTTDSSNDE 174

Query: 185 SPDWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
               L+   E  +R+T  + +  + HG+GCTL++++A L
Sbjct: 175 IEHRLYHHAELLERYTYTK-LPGDYHGSGCTLASSIAGL 212


>UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobacter formigenes
           RepID=C3X5F6_OXAFO
          Length = 272

 Score =  113 bits (282), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 82/256 (32%), Positives = 133/256 (51%), Gaps = 14/256 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L  +G DPSGGAGI AD++   A+GA+   V+TAL  Q+   V +V  ++   ++ Q   
Sbjct: 19  LVFSGLDPSGGAGISADIEAIGAVGAHALPVVTALTVQDNDRVYAVNPVDAAIISRQAQV 78

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN----VVLDTVMLAKSGDPLLSPSAV 122
           +   + +   K+G++   D   A+ E +   + +     VVLDTV+ +  G  L   +  
Sbjct: 79  LAGKIPVSAVKVGIVGNRDNAVAIGEVISELRRKQPGLPVVLDTVLGSGHGFALADGTPE 138

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L S L+   +L+TPNLPEA  L   P A+  +   +Q   L+A G   VL+KGGH +D
Sbjct: 139 YAL-SPLIGMATLVTPNLPEAKRL--CPLAKDTR---KQAEYLMAQGAANVLIKGGHGED 192

Query: 183 EQS--PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             S    W F  +G +++   R +    HGTGCTL++A+AA   +       +++ + W 
Sbjct: 193 ADSVFNQW-FGADGMKQWKWRR-LPGEFHGTGCTLASAIAAYLAQGLLMEKALEKGQVWC 250

Query: 241 SSALAQADTLEVGHGI 256
            +AL +A ++  G  I
Sbjct: 251 QAALEKAFSIAKGQKI 266


>UniRef50_C9RIY8 Phosphomethylpyrimidine kinase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RIY8_FIBSS
          Length = 250

 Score =  113 bits (282), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 84/246 (34%), Positives = 134/246 (54%), Gaps = 21/246 (8%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG D S GAGI AD+KT +  G +  SV TAL  QN     +   +  + + AQL+
Sbjct: 8   ALTIAGFDGSAGAGILADVKTMAHFGVFCESVCTALTQQNEDEFVAPGWVIWERIEAQLE 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERL-QRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           ++F+  +    KIG++ +  +++ + E + ++     +V D +  A +G   +  +    
Sbjct: 68  TLFAKRQFKFVKIGLVEKAKVLQRIVEFVREKSPDAYIVWDPIASASAGFHFMRSAE--- 124

Query: 125 LRSRLLP---QVSLITPNLPEAAAL-LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            R   +P   Q+ L+TPNL E   L  +   +R +    E G+        A+L+KGGH 
Sbjct: 125 -RDEFMPVMKQIDLVTPNLDEFGFLGFEQAASRGK---FEFGKDF------ALLLKGGHS 174

Query: 181 DDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAA-LAALRPRHTNWADTVQEAKS 238
            D+++ D L+ R+G+Q +FT+PRI     HGTGC LS+A LA L   HT   ++ Q AK+
Sbjct: 175 TDDEAVDTLWDRDGKQYKFTSPRIPGNGKHGTGCHLSSAILANLALGHT-LPESCQIAKN 233

Query: 239 WLSSAL 244
           +L+  L
Sbjct: 234 YLTELL 239


>UniRef50_A4NVQ6 Phosphomethylpyrimidine kinase n=2 Tax=Haemophilus influenzae
           RepID=A4NVQ6_HAEIN
          Length = 189

 Score =  113 bits (282), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 73/189 (38%), Positives = 106/189 (56%), Gaps = 11/189 (5%)

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA+ L       +VLD VM+AK G PLL   AV+ L  +LLP   +ITPN
Sbjct: 1   MLGNAEIIECVADFLADKPFGALVLDPVMIAKGGAPLLQQQAVSALSQKLLPLADVITPN 60

Query: 140 LPEAAALLDAPHARTEQEMLEQ-GRSLLAMGCGAVLMKGGHLDDEQSP---DWLFTREGE 195
           +PEA AL     A  +   ++Q  ++L   G   V++KGGH  + QS    DW+   +G 
Sbjct: 61  IPEAEALTGI--AIVDDISIQQAAKALQKQGAKNVIIKGGHSLNSQSELCQDWVLLADG- 117

Query: 196 QRFT--APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVG 253
           + FT  +PR  T +THGTGCT SA L A   +       V+ AK ++++A++    L +G
Sbjct: 118 RHFTLQSPRFNTPHTHGTGCTFSACLTAELAKGEPLQSAVKTAKDFITAAISH--PLNIG 175

Query: 254 HGIGPVHHF 262
            G GP +H+
Sbjct: 176 QGQGPTNHW 184


>UniRef50_Q11YI3 Phosphomethylpyrimidine kinase n=1 Tax=Cytophaga hutchinsonii ATCC
           33406 RepID=Q11YI3_CYTH3
          Length = 249

 Score =  112 bits (281), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 12/250 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +++   L+IAG DP+ GAGI AD+KTF+A G+YG +V T L AQ     + V       +
Sbjct: 5   LEKPYVLSIAGLDPTAGAGILADVKTFTATGSYGFAVATCLTAQTEDTCEHVQWFSVKEI 64

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSP 119
             QL  +  +  I  TK+G + +  + EA+ + +  Y      VLD ++   SG   +  
Sbjct: 65  TTQLKPLLENYPIAVTKLGAMKDLVMTEALIDFVLEYNPDMKFVLDPILSTSSGKEFMKL 124

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           +A       LL +V L+TPN PE   L       TE +   +   +L+M    V +KGGH
Sbjct: 125 NADI---KELLSKVYLLTPNYPEIQML-------TENQNALEAAMVLSMHTN-VYLKGGH 173

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            ++E   D LF       F   R      HG+GC LS+++A+   +  + A+  +EA  +
Sbjct: 174 SNEEILVDRLFVEGVMTEFPKQRNAIAKKHGSGCVLSSSIASFLAQGKSLAEASEEAAKY 233

Query: 240 LSSALAQADT 249
           +    +  +T
Sbjct: 234 MCGFFSSTET 243


>UniRef50_D1PXN3 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella bergensis DSM
           17361 RepID=D1PXN3_9BACT
          Length = 362

 Score =  112 bits (281), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 75/253 (29%), Positives = 123/253 (48%), Gaps = 12/253 (4%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+I G+D +G +GIQAD+KT SALG Y  + +T +  Q+ +G+  +  +  D V  Q+ +
Sbjct: 8   LSITGSDNTGASGIQADIKTISALGGYALTALTTVTVQDGQGIHDLLNLPCDIVVRQVRA 67

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERL----QRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           V       T K+GM+ + D + A+ + +    Q+  +  +      L   G  L+   A+
Sbjct: 68  VIEAHHPKTVKVGMVRDADTIAALKDEIVGCPQKVMVPGI------LTSHGKQLIGNEAI 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
              +  L+P+ +++     EA  LL +P   ++ EMLE  +   AMG  AVL++GGH  +
Sbjct: 122 RAWKQELIPEATVLLTRCNEAEILLGSP-IVSDDEMLEAAQQFTAMGAQAVLIRGGHQTE 180

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            +    L   E  Q F++        HG G  LSAA+A      +N    +  A  +L S
Sbjct: 181 GRLTAVLMAGEKHQFFSSQNTEGWQRHGVGGALSAAIATHLAMGSNITTAISRAHDYLHS 240

Query: 243 ALAQADTLEV-GH 254
            +  A    V GH
Sbjct: 241 QVVYAVDCRVQGH 253


>UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepID=PDXK_TREPA
          Length = 269

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 74/229 (32%), Positives = 114/229 (49%), Gaps = 4/229 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQN-TRG-VQSVYRIEPDFVAAQLDSVFSDVRIDTTK 77
           I+ADLKTF   GA+G + +TA+V  + +R     V+ +E D V  QL++ F+ V +   K
Sbjct: 18  IEADLKTFQEYGAFGVATLTAIVTMDPSRNWSHRVHSLEEDCVRDQLETAFAGVGVSAVK 77

Query: 78  IGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
            GMLA    +E VAE L+R+ +   V D VM+ K     L       +  +LLP+ +++T
Sbjct: 78  SGMLASVHAIECVAEYLERFAVAAYVFDPVMVCKGSGDALHRELNELMIQKLLPRATVVT 137

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL--DDEQSPDWLFTREGE 195
           PNL E A +      RT  EM E  R +   G   V +KGG      + + D  +  +  
Sbjct: 138 PNLFETAQIAGISVPRTVDEMKEGARLIHERGASHVFVKGGGRLPGCKHALDVFYDGKTF 197

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
                  + +   HG GCT+SAA+ A   R     D +  AK ++++ L
Sbjct: 198 HLVEDELVQSGWNHGAGCTVSAAITAGLGRGLTAYDAILSAKRFVTTGL 246


>UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobacter
           RepID=A1TYG7_MARAV
          Length = 253

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 85/250 (34%), Positives = 130/250 (52%), Gaps = 13/250 (5%)

Query: 9   IAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVF 68
           ++G DPSGGAGIQAD++  +++GA+   V+T L  Q+TR V     + PD +  QL+ + 
Sbjct: 2   LSGLDPSGGAGIQADIQAITSIGAHPLPVLTCLTVQDTRNVYGAEPVSPDLIKQQLECLA 61

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSR 128
            D  I   K G L   ++VE + E +Q++    +++D V+ A  G  L   + VA ++ +
Sbjct: 62  QDTPIHAIKTGALGNAEVVEVLVEFVQKHSGVPLIVDPVIKAAGGGDLADDALVAAMKDK 121

Query: 129 LLPQVSLITPNLPEAAAL--LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           L  +  +ITPN  E A L   D P         E  R+LL  GC +VL  GGH       
Sbjct: 122 LFARAEMITPNGVELAQLGGSDNP--------AEAARNLLQTGCESVLATGGHGSGIHII 173

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           + L+    E   +   R+     HGTGCTL+AA+AA R    +    + +A++++  AL 
Sbjct: 174 NTLYNHAPEPMEWEVERVGANEYHGTGCTLAAAIAAGRAMGLSPRAAISQAQNYVHRALL 233

Query: 246 QADTLEVGHG 255
            A  L VG G
Sbjct: 234 HA--LTVGQG 241


>UniRef50_A1ZKW7 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Microscilla marina ATCC 23134 RepID=A1ZKW7_9SPHI
          Length = 250

 Score =  111 bits (277), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 75/222 (33%), Positives = 113/222 (50%), Gaps = 11/222 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +R N L+IAG DPSGGAGI AD+KTF +    G +V T+L  QN    +    +  + + 
Sbjct: 4   ERPNILSIAGFDPSGGAGILADVKTFESHKTLGMAVCTSLTVQNDVAFEKANWVAIEDIK 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPS 120
           AQL ++ +  R    KIG++   D+++ +   L+ +  Q  +V D V+ A +G    S  
Sbjct: 64  AQLVTLGARFRFKVAKIGLVESFDVLQQIVAILREHNPQIKIVCDPVLKASAGFVFHSEV 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A   L + LLP + L+TPN  E   L     A+        G   L+  C  V +KGGH 
Sbjct: 124 AKQQLEA-LLPHLFLLTPNWEEVQQLSGVKDAKA-------GAHYLSQFC-HVYLKGGHN 174

Query: 181 DDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAA 221
            +    D+LF+++ +   F   R      HG+GC  S+ALAA
Sbjct: 175 TEALGKDFLFSQQQKVYAFNPKRTNVAGKHGSGCVFSSALAA 216


>UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 open reading frames
           n=3 Tax=Pichia angusta RepID=Q04326_PICAN
          Length = 379

 Score =  111 bits (277), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 95/284 (33%), Positives = 138/284 (48%), Gaps = 39/284 (13%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LT+AG+D SGGAGI+AD+KT +A   Y  + ITAL AQN+ GV +V     + V   L +
Sbjct: 36  LTVAGSDSSGGAGIEADVKTITAHKCYAVTCITALTAQNSLGVHNVTTTPAETVEKVLVA 95

Query: 67  VFSD-VRIDTTKIGMLAE---TDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           +  D + +D  K+GML +   + I   +A R  R  I   VLD V +AK+GD L   S+V
Sbjct: 96  IADDQIALDAIKLGMLPDETLSVITPFLAARAARTPI---VLDPVFVAKNGDRL---SSV 149

Query: 123 ATLRS--RLLPQVSLITPNLPEAAALLDAPHAR----------TEQEMLEQGRSLLAMGC 170
             L+    L    +LITPN  E   LL    +           T  +     R L +   
Sbjct: 150 GALKKAVELFQHAALITPNSREVEVLLAVLRSSDPSVEEITITTADDFYTAARLLGSRFK 209

Query: 171 GAVLMKGGHLD-------DEQSPDWLFTREGEQR------FTAPRIMTKNTHGTGCTLSA 217
             VL KGG +        D ++P ++     E R      F +  I + N HGTGCTLS+
Sbjct: 210 VDVLFKGGLVPVNENLAVDPENPVYILNVLYEHRSEKLTVFRSNHIDSPNLHGTGCTLSS 269

Query: 218 ALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           A+A    R  + A  V+ A  +++ A+  A+        GP++H
Sbjct: 270 AVACYLARGASLATAVENAIGFVNEAIRHAEV----KPNGPLNH 309


>UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neorickettsia
           RepID=C6V659_NEORI
          Length = 254

 Score =  110 bits (276), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 81/246 (32%), Positives = 127/246 (51%), Gaps = 9/246 (3%)

Query: 1   MKRINALTI-AGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M++I  + I AG+D  GGAG+QADL+  + LG    +V+T + AQ+ +GV ++  +  + 
Sbjct: 1   MRKIPEICIVAGSDSIGGAGLQADLRIAALLGCSASNVVTCITAQDLKGVHAIQYLSGEI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V+ QL    S  +    KIGML  ++I  AV + L+   I  +VLD V+++ S   L   
Sbjct: 61  VSKQLICALSR-KPKAIKIGMLGNSEIALAVYDVLKDTGIP-IVLDPVLISTSNSKLADE 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            AV  L  +LL    L+TPNL EA+ L        E   +   R +  +G   VL+KG H
Sbjct: 119 GAVQVLLKKLLSISHLVTPNLFEASTLSGNKVFDAESAKIAALR-IFELGAKNVLVKGIH 177

Query: 180 LDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           + + +  D L ++ G    F    I    THG+GC LS A+A     H +   +++E+  
Sbjct: 178 IKEGKIMDLLISQGGATMEFQNEVIRINITHGSGCRLSTAIAC----HMSMGKSLRESIH 233

Query: 239 WLSSAL 244
           + S  L
Sbjct: 234 FASDLL 239


>UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Proteobacteria
           RepID=C0N961_9GAMM
          Length = 480

 Score =  110 bits (274), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 77/251 (30%), Positives = 127/251 (50%), Gaps = 8/251 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +   L I G DP G AGI AD+ T      +   +ITA+  Q++ G+ ++  +  + +
Sbjct: 1   MAKPAVLLIGGLDPQGCAGIAADIATVQHHDCHPLPLITAMTEQSSAGLTALGAVNTNKL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ  +  +D  I   K+G++ +  I E V + L       VV+D V+ + SG   ++  
Sbjct: 61  MAQYRNCKADFDIQAIKVGLIPDLIIAEKVKQILLDNPGIPVVMDPVLASSSGGKTVADG 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAM-GCGAVLMKGGH 179
               +R  LL  ++L+TPNLPE + L D        E +EQ  ++L+  G  A L+KGGH
Sbjct: 121 VRQYIRDELLQHLTLLTPNLPELSLLTD------NLEDVEQATTILSQKGLQACLVKGGH 174

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D E + D+ F  E  + +        +  GTGC L++A+A+      +  D V  AK++
Sbjct: 175 ADSEFATDF-FISEQVRFYCYQTKYASDVRGTGCVLASAIASHLASGQDMRDAVVLAKTY 233

Query: 240 LSSALAQADTL 250
           +S  + QA T+
Sbjct: 234 VSRGIRQAQTV 244


>UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BQI9_9GAMM
          Length = 271

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 9/250 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L  AG DP+GGAGI AD++  ++ G +   +IT++  Q+TR V     +    VAAQ ++
Sbjct: 10  LVFAGHDPTGGAGICADIQALASQGCHTAPIITSITTQDTRNVFENKPLSSTLVAAQAEA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V +D+ I   KIG+L   +I+EAV   L ++    VV+D V++A  G  L        + 
Sbjct: 70  VLADLPIAACKIGLLGSIEIIEAVQHLLLKHPHLPVVVDPVLVAGGGYSLTQDKVRDAMI 129

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
            +LLP   +ITPN PEA+AL           +      L+  GC  V + G H D     
Sbjct: 130 KKLLPLTQIITPNSPEASALTG-----ITNSLNAAATRLMDYGCQHVCITGTHEDTPLVK 184

Query: 187 DWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
           + L++   + Q +T  R +  + HG+GCT +A+LA    +  +    V +A+ +  + L 
Sbjct: 185 NTLYSHGQQIQSWTWTR-LPHSYHGSGCTFAASLAGFLAQGIDMVTAVYKAQHYTWTTLQ 243

Query: 246 QADTLEVGHG 255
           +    + GHG
Sbjct: 244 RG--FKPGHG 251


>UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithiobacillus
           ferrooxidans RepID=B5ERP1_ACIF5
          Length = 277

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 89/247 (36%), Positives = 128/247 (51%), Gaps = 6/247 (2%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           LTIAG+DPS GAG+QADL T ++LG +GC+ +TAL  Q++  V+    ++P    AQ  +
Sbjct: 16  LTIAGSDPSAGAGLQADLLTLASLGVHGCTAVTALTVQDSVNVRGYTPVDPQDTVAQARA 75

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+ +   KIGML    +V AV+  L  +    VVLD V+ A  G  L        L 
Sbjct: 76  VLEDMSVQVIKIGMLGSAAMVAAVSALLADHSQIPVVLDPVLAAGGGMALAGDGLREALV 135

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           +RLLP+V+++TPN PEA AL          ++   G  L   G    L+ GGH ++ +  
Sbjct: 136 TRLLPRVTVMTPNGPEALAL------SGTGDLPAAGVWLNRHGAEWALISGGHGEEPELE 189

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           + LF  E  +R      +  + HG+GCTL+AALAA         + V  A  +  + L  
Sbjct: 190 NLLFRGEVLRRTFRQARLPHSYHGSGCTLAAALAAGLAHGLTMEEAVARALDFTHACLVH 249

Query: 247 ADTLEVG 253
           A  L  G
Sbjct: 250 AYPLGKG 256


>UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosphate diphosphorylase
           n=2 Tax=Shewanella RepID=A1S6Q8_SHEAM
          Length = 525

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 89/264 (33%), Positives = 132/264 (50%), Gaps = 29/264 (10%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADL T   LG YGCSVITA+ AQN+  V +V  + P  + AQL+++ +D+     KIG
Sbjct: 27  IQADLLTLQDLGCYGCSVITAITAQNSVAVTAVEPVTPRMLRAQLETLKADLYPSAVKIG 86

Query: 80  MLAETDIVEAVAERL-QRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR---------SRL 129
           ++A    ++ +A+ L +      V+LD VM+A  G  L SP      +         S  
Sbjct: 87  LIANQPQLDFLADWLGENLPGVPVILDPVMVASCGGDLQSPDNTCPDKTGERSGLDFSPF 146

Query: 130 LPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL--AMGCGAVLMKGGHLDDEQSPD 187
             ++SLITPN  E + L+       + + LE   ++L  A G G++L KGG    +QS  
Sbjct: 147 AGKISLITPNKAELSRLIG--RLLNDDDALEWAANVLWQAFG-GSILAKGGDCPWQQSKA 203

Query: 188 WLFTREGEQRFTAP------------RIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
                 G+    +P            R+ T + HG+GCTLS+A+AA   +     D V  
Sbjct: 204 RDLLLLGDIATISPLHRRQGFWLSNERVATVHNHGSGCTLSSAIAAFVAKGLVLPDAVLL 263

Query: 236 AKSWLSSALAQADTLEVGHGIGPV 259
           AK+++   L QA    VG G GP+
Sbjct: 264 AKAYVFEGLRQASA--VGSGPGPL 285


>UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F6FE
          Length = 274

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 78/258 (30%), Positives = 131/258 (50%), Gaps = 8/258 (3%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQN-TRGVQSVYR-IEPDFVAAQL 64
           LTIAG+D SGGAG++ADLK F   GA+G + +T +V  +   G   V   I+P+ V  QL
Sbjct: 6   LTIAGSDVSGGAGLEADLKMFEEYGAFGTAAVTCIVTFDPNDGFSHVIEFIDPEVVTRQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +S  +  + D  K GML   +    +A++L+  ++   V D V++ K    ++    +  
Sbjct: 66  ESTLAVHKFDAIKSGMLGSVENALVLAQKLKTNELP-YVFDPVLVCKGAGTMVDLKDL-- 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
               L+P  ++ITPNL EAA L       + + M+E  + + A G   V++KGG  L  E
Sbjct: 123 FVDNLVPLATVITPNLEEAATLAGLEPIDSVEGMVEAAKIIHAQGAKNVVVKGGARLAGE 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D +F  E      + ++  K  +G GC+ ++++AA         D V  AK  ++  
Sbjct: 183 DAIDIVFDGESITTLRSRKVNEKLVNGAGCSFASSIAAGITTGLIIQDAVVSAKEKVAHG 242

Query: 244 LAQADTLEVGHGIGPVHH 261
           +  A+ L+   G+  + H
Sbjct: 243 I--ANCLDNATGVASLFH 258


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria...   347   2e-94
UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH     344   2e-93
UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenho...   342   7e-93
UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionell...   341   1e-92
UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspi...   340   2e-92
UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S...   338   1e-91
UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroi...   337   3e-91
UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia ...   336   6e-91
UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingoba...   333   5e-90
UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria...   330   4e-89
UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   329   7e-89
UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphometh...   328   8e-89
UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular ...   328   1e-88
UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular ...   326   5e-88
UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacte...   325   1e-87
UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyr...   324   2e-87
UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli ...   324   2e-87
UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   323   4e-87
UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria...   322   7e-87
UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria...   322   1e-86
UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   321   2e-86
UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 clu...   321   2e-86
UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquifical...   320   2e-86
UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroid...   317   2e-85
UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   317   3e-85
UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   316   4e-85
UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomon...   315   1e-84
UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsi...   315   1e-84
UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria...   314   2e-84
UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   314   2e-84
UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpy...   312   7e-84
UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   312   9e-84
UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   311   2e-83
UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantell...   311   2e-83
UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM      310   2e-83
UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agarica...   310   3e-83
UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria...   310   4e-83
UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   309   5e-83
UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfati...   308   1e-82
UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Cor...   307   3e-82
UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteoba...   307   3e-82
UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   307   4e-82
UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntropho...   306   5e-82
UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokel...   305   7e-82
UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   305   9e-82
UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinib...   305   9e-82
UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular...   305   1e-81
UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasma...   305   1e-81
UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q...   304   2e-81
UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptoco...   304   2e-81
UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   304   2e-81
UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobact...   303   4e-81
UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillal...   303   4e-81
UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rh...   303   5e-81
UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebact...   302   7e-81
UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   302   7e-81
UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanoca...   301   1e-80
UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamin...   301   2e-80
UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   300   2e-80
UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicro...   299   7e-80
UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria ...   298   1e-79
UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia d...   297   2e-79
UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicute...   297   3e-79
UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovu...   297   4e-79
UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   296   5e-79
UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   296   6e-79
UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   295   1e-78
UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanae...   294   2e-78
UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Fl...   294   2e-78
UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leo...   294   3e-78
UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   293   5e-78
UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria ...   293   6e-78
UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   292   6e-78
UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_...   291   2e-77
UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpy...   291   2e-77
UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobiu...   290   5e-77
UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobac...   288   1e-76
UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobacul...   288   1e-76
UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   287   2e-76
UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular...   286   4e-76
UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprother...   286   7e-76
UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Br...   286   7e-76
UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovi...   285   8e-76
UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholde...   285   1e-75
UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobac...   285   1e-75
UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=unculture...   285   2e-75
UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepI...   284   2e-75
UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes...   284   3e-75
UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermopla...   283   6e-75
UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobia...   282   8e-75
UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   282   8e-75
UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniob...   282   9e-75
UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   281   1e-74
UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatu...   281   2e-74
UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Ru...   281   2e-74
UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   280   4e-74
UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetoco...   280   5e-74
UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobaci...   279   8e-74
UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochloro...   277   2e-73
UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Ve...   276   6e-73
UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharop...   276   6e-73
UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold...   275   8e-73
UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kina...   275   1e-72
UniRef50_C2CTG3 Multifunctional thiamine-phosphate pyrophosphory...   275   1e-72
UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermob...   275   1e-72
UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 ...   275   1e-72
UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   274   2e-72
UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella...   273   3e-72
UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (H...   273   4e-72
UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium...   273   5e-72
UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidi...   272   7e-72
UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobac...   272   8e-72
UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   272   9e-72
UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodes...   271   1e-71
UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   271   2e-71
UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionib...   271   2e-71
UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CB...   270   2e-71
UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   269   6e-71
UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phos...   268   9e-71
UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   268   2e-70
UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   267   2e-70
UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Loddero...   266   4e-70
UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridi...   266   4e-70
UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   266   5e-70
UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Sac...   266   7e-70
UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas...   265   8e-70
UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS2...   265   1e-69
UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bactero...   265   1e-69
UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   264   2e-69
UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadr...   264   2e-69
UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosa...   263   3e-69
UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine ar...   263   4e-69
UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanoco...   262   1e-68
UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   261   1e-68
UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular ...   261   1e-68
UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=...   261   1e-68
UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospir...   261   2e-68
UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kan...   261   2e-68
UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria ...   261   2e-68
UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioi...   261   2e-68
UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaer...   260   3e-68
UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   260   3e-68
UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria Re...   260   3e-68
UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   259   6e-68
UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S...   259   7e-68
UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   258   1e-67
UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria ...   258   1e-67
UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomy...   258   1e-67
UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosph...   258   2e-67
UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomo...   257   2e-67
UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Ta...   257   4e-67
UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   256   4e-67
UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   256   4e-67
UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavisp...   256   5e-67
UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobact...   256   6e-67
UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 ...   256   7e-67
UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Mar...   256   7e-67
UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyri...   255   2e-66
UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofu...   254   2e-66
UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-...   253   5e-66
UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolob...   253   6e-66
UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma...   252   7e-66
UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), Th...   252   7e-66
UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax...   251   1e-65
UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   251   2e-65
UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolob...   251   2e-65
UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax...   251   2e-65
UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteob...   250   4e-65
UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosac...   250   5e-65
UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia ...   248   1e-64
UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) ...   248   2e-64
UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphil...   248   2e-64
UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcani...   247   2e-64
UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonell...   247   3e-64
UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus ...   247   4e-64
UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkal...   246   5e-64
UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpy...   246   6e-64
UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivall...   246   6e-64
UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=...   246   7e-64
UniRef50_C5A6B1 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Th...   246   8e-64
UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta pro...   245   1e-63
UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Man...   245   2e-63
UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   244   2e-63
UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax...   244   2e-63
UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   244   2e-63
UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptoco...   244   3e-63
UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   242   1e-62
UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynt...   240   3e-62
UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=...   240   3e-62
UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochrom...   240   4e-62
UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosph...   239   6e-62
UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax...   239   7e-62
UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella ...   239   7e-62
UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   239   8e-62
UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q75...   238   1e-61
UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacte...   238   1e-61
UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   238   1e-61
UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerot...   238   2e-61
UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiob...   237   2e-61
UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=...   237   3e-61
UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobact...   237   3e-61
UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 ope...   237   3e-61
UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Co...   236   5e-61
UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospir...   236   6e-61
UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobac...   236   8e-61
UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Pro...   235   1e-60
UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales Re...   235   1e-60
UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisp...   234   2e-60
UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogeno...   234   2e-60
UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermans...   234   2e-60
UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepI...   234   2e-60
UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobact...   233   4e-60
UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomyc...   233   5e-60
UniRef50_C0X709 Possible phosphomethylpyrimidine kinase n=22 Tax...   233   5e-60
UniRef50_B9E8N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   232   7e-60
UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa...   232   8e-60
UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Br...   231   2e-59
UniRef50_C5RC57 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   230   3e-59
UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular...   230   3e-59
UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobact...   229   6e-59
UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpy...   229   1e-58
UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   228   2e-58
UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   227   3e-58
UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   227   4e-58
UniRef50_D1PXN3 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   227   4e-58
UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglo...   226   5e-58
UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   226   6e-58
UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobac...   226   7e-58
UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) ...   226   7e-58
UniRef50_C6XZH6 Phosphomethylpyrimidine kinase n=3 Tax=Sphingoba...   224   2e-57
UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   224   2e-57
UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithio...   224   2e-57
UniRef50_A6EM49 Phosphomethylpyrimidine kinase n=1 Tax=unidentif...   224   3e-57
UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neoricket...   223   6e-57
UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobu...   223   7e-57
UniRef50_C9RIY8 Phosphomethylpyrimidine kinase n=1 Tax=Fibrobact...   222   1e-56
UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Ge...   221   1e-56
UniRef50_Q0FHB8 Phosphomethylpyrimidine kinase ThiD n=2 Tax=Rhod...   221   2e-56
UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   221   3e-56
UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax...   219   5e-56
UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 T...   219   7e-56
UniRef50_A1ZKW7 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   219   9e-56
UniRef50_C6NTD4 Phosphomethylpyrimidine kinase n=1 Tax=Acidithio...   218   1e-55
UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepI...   218   2e-55
UniRef50_A4C197 Phosphomethylpyrimidine kinase n=1 Tax=Polaribac...   217   3e-55
UniRef50_B1MZ30 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   216   5e-55
UniRef50_B4U544 Phosphomethylpyrimidine kinase n=3 Tax=Streptoco...   215   1e-54
UniRef50_D0LJB6 Phosphomethylpyrimidine kinase n=1 Tax=Haliangiu...   215   2e-54
UniRef50_C4R5Q7 Multifunctional protein with both hydroxymethylp...   214   2e-54
UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosph...   214   3e-54

Sequences not found previously or not previously below threshold:

>UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria RepID=B1KWX2_CLOBM
          Length = 275

 Score =  347 bits (891), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 112/266 (42%), Positives = 173/266 (65%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   L+IAG+D SGGAGIQADLKTFSA G +G SVI ++VA+NT  V  +  + PD +
Sbjct: 1   MKK--VLSIAGSDCSGGAGIQADLKTFSAHGVFGMSVIVSVVAENTSRVIDIQDVTPDMI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+D+V+ D+  D  KIGML+  D ++AV+E+LQ Y+ +N+V+D VM AK+G PL+ P+
Sbjct: 59  KSQIDAVYEDIGTDAVKIGMLSTPDCMKAVSEKLQEYKPKNIVIDPVMYAKNGCPLMDPN 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           +V+TL   ++    ++TPN+PEA  +      +T ++M +    +  MGC +VL+KGGH 
Sbjct: 119 SVSTLIESIVYHADILTPNIPEAERISGYK-IKTLEDMEKAAGIIEGMGCKSVLIKGGHY 177

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             + + D L+       +   RI TKNTHGTGCTLS+A+A+         + V+ AK+++
Sbjct: 178 IGD-AVDVLYDGNKFYHYKTQRIHTKNTHGTGCTLSSAIASNLALGFEINEAVKRAKNYI 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           + A+    +LE+G G GP +HF+  +
Sbjct: 237 TMAIEH--SLEIGKGNGPTNHFYQVY 260


>UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH
          Length = 522

 Score =  344 bits (883), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 117/266 (43%), Positives = 159/266 (59%), Gaps = 2/266 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LT+AG+D   GAGIQADLK  +A G Y  SVITA+ AQNTRGVQSV+ + P+F++
Sbjct: 29  KVPQVLTVAGSDSGAGAGIQADLKVCAARGVYCASVITAVTAQNTRGVQSVHLLPPEFIS 88

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL SV SD   D  K GML  T+IVE + + L  + ++ +V+D VM++ SG  L   S 
Sbjct: 89  EQLKSVLSDFEFDVVKTGMLPSTEIVEVLLQNLSDFPVRALVVDPVMVSTSGHVLAGSSI 148

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           ++  R RLLP   +ITPN+ EA+ALLD     T  EM    +SL  MG   VL+KGG L 
Sbjct: 149 LSIFRERLLPIADIITPNVKEASALLDGFRIETVAEMRSAAKSLHEMGPRFVLVKGGDLP 208

Query: 182 D-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D   S D  F  +      +PRI T+NTHGTGCTL++ +AA   + ++    V+ AK ++
Sbjct: 209 DSSDSVDVYFDGKEFHELRSPRIATRNTHGTGCTLASCIAAELAKGSSMLSAVKVAKRFV 268

Query: 241 SSALAQADTLEVGHG-IGPVHHFHAW 265
            +AL  +  + +G G  GP  HF   
Sbjct: 269 DNALDYSKDIVIGSGMQGPFDHFFGL 294


>UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenhoekiella blandensis
           MED217 RepID=A3XJN4_9FLAO
          Length = 277

 Score =  342 bits (878), Expect = 7e-93,   Method: Composition-based stats.
 Identities = 107/268 (39%), Positives = 157/268 (58%), Gaps = 5/268 (1%)

Query: 1   MKR---INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK+      L+IAG D SGGAGIQADLKT SALG Y  +V+TAL  QNT GVQS++ I  
Sbjct: 1   MKKYQYPTVLSIAGFDGSGGAGIQADLKTISALGCYATTVLTALPVQNTTGVQSIFSIPT 60

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
             V  QLDS+F D++    KIGM+   ++VE +A +L+ Y    VV D VM+A SG  L+
Sbjct: 61  SVVKEQLDSIFDDIQPSAIKIGMVHTPELVETIAAKLKNYPKIPVVFDPVMVATSGHKLI 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
               + ++   L P   +ITPN+ EAA L   P   T ++M   G  +L + C +VL+KG
Sbjct: 121 EDETIKSITELLFPLADVITPNMDEAAILAQMP-VETIEDMRIAGNKILDLSCKSVLLKG 179

Query: 178 GHLDDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GHL  +      F  +     F   +  T+N HG+GCTLS+A+A+   +  +  ++V +A
Sbjct: 180 GHLKSDLLTSLFFGPDKTVDEFEFEKFETQNMHGSGCTLSSAIASFLAQKNSLLNSVTKA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHA 264
           + ++  A+  A  +++G G GP++HF  
Sbjct: 240 QEYVHQAIYHAKEVKIGKGNGPLNHFFN 267


>UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionella
           RepID=C6MZJ4_9GAMM
          Length = 273

 Score =  341 bits (876), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 129/266 (48%), Positives = 169/266 (63%), Gaps = 3/266 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               L+IAG D SGGAGIQADLKTFSA G YG +V+TAL  QNT GV++ Y I    +  
Sbjct: 2   HYKTLSIAGFDGSGGAGIQADLKTFSAFGCYGMTVLTALPVQNTCGVRNCYDIPLQAIDD 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSA 121
           QL ++F D+R D  KIGML  ++I+E VA  L+++ +   ++LD V +AKSGDPLL P A
Sbjct: 62  QLHAIFDDIRPDGIKIGMLFNSEIIELVAAFLKKHARDIPIILDPVTVAKSGDPLLLPEA 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V TL ++L+P  +LITPNLPEA        A++E+EML   + LL +G   VL+KGGHL 
Sbjct: 122 VDTLITKLMPLATLITPNLPEAHTFTGV-DAQSEEEMLVVAQKLLDLGPQYVLLKGGHLL 180

Query: 182 DEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              S D L  + G    F +PRI +KNTHGTGCTLSAA+ A   ++       + AK +L
Sbjct: 181 ASTSNDLLIGKNGTRHWFESPRIESKNTHGTGCTLSAAITACLAQNVEIEKACEIAKRYL 240

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
            +A+  A    VG G GPVHHF+  W
Sbjct: 241 FNAIKAAKDNSVGKGHGPVHHFYHLW 266


>UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspira
           RepID=C0R0V9_BRAHW
          Length = 269

 Score =  340 bits (874), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 123/264 (46%), Positives = 166/264 (62%), Gaps = 2/264 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           + ALTIAG D SGGAGIQADLKTFSALG YG  V+TAL  QNT+GV+S Y IE   +  Q
Sbjct: 2   VKALTIAGFDGSGGAGIQADLKTFSALGCYGMCVLTALPVQNTQGVRSCYEIELKAIKEQ 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAV 122
           L+ +F D+  D  KIGML  +DI++ VA+ L    +   +++D VM+AKSGD LL   AV
Sbjct: 62  LECIFDDIIPDAIKIGMLFNSDIIKLVADFLSNNAKNIPIIVDPVMVAKSGDRLLLEEAV 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
            +L+  +LP  +++TPN+PEA  L      +T+ +M++    +L MG   V++KGGHL+ 
Sbjct: 122 DSLKKYILPISTVVTPNIPEAEDLTS-KKIKTDDDMIDAANDILNMGAKNVMLKGGHLEG 180

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E S D    +E ++   A RI TKNTHGTGCTLSAA+ +         +  +  K +L +
Sbjct: 181 ELSRDLFINKESKEFLDALRIDTKNTHGTGCTLSAAICSYIAHGKTPLEASKLGKQYLFN 240

Query: 243 ALAQADTLEVGHGIGPVHHFHAWW 266
           AL  A    VG G GPVHHF+  W
Sbjct: 241 ALQAAKVDSVGKGHGPVHHFYEAW 264


>UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S3_LACBS
          Length = 511

 Score =  338 bits (867), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 112/283 (39%), Positives = 156/283 (55%), Gaps = 24/283 (8%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           + LTIAG+D SGGAGIQADLKTF+A G YG SVITAL AQNT+GV  V+   P+FVA Q+
Sbjct: 8   SVLTIAGSDSSGGAGIQADLKTFAAHGCYGASVITALTAQNTQGVHGVHPCPPEFVAQQI 67

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY----QIQNVVLDTVMLAKSGDPLLSPS 120
            SV  D+ I+  K GML + +  + V + L+ +     +  ++ D V ++ SG  LL P 
Sbjct: 68  HSVLEDLEINAIKTGMLYDVENTKQVVKSLKAHYKNKALPPLICDPVCVSTSGHTLLHPE 127

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAP----HARTEQEMLEQGRSLLAMGCGAVLMK 176
           AV  L   L P  +LITPN  EA  LL +        + ++ML     LL+ GC AVL+K
Sbjct: 128 AVEILIDELFPLATLITPNKAEAELLLSSRNPFVDITSLEDMLSATEQLLSFGCAAVLLK 187

Query: 177 GGHLDD-------------EQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAAL 222
           GGH+               E   D L+   G++  F  PRI + +THGTGCTLS+A+A  
Sbjct: 188 GGHITSTMTDTGINVADHPELVVDVLYQSNGKKSLFVMPRIESTSTHGTGCTLSSAIACE 247

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
                +  +  + A  +    +  A    +G G GP++H H+ 
Sbjct: 248 LACGLSLEEATKNAAIFTHMGIEAAH--PMGKGHGPLNHLHSL 288


>UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroides
           RepID=Q5LCW2_BACFN
          Length = 277

 Score =  337 bits (865), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 112/264 (42%), Positives = 157/264 (59%), Gaps = 2/264 (0%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L+IAG+D SGGAGIQAD+KT SALGAY  SVITA+  QNTRGV++V+ +  + 
Sbjct: 1   MKTYPVVLSIAGSDCSGGAGIQADIKTISALGAYAASVITAVTVQNTRGVKAVHTVPAEI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V  Q+++V  D+R D  KIGM++E  +V+ +A  L +Y    +V D VM++ SG  L++ 
Sbjct: 61  VQGQIEAVMEDLRPDALKIGMVSEPALVKIIAGCLLKYPHCPIVYDPVMVSTSGRKLMAK 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  ++  L P  SLITPNL E   L       T +EM E  R L      AVL+KGGH
Sbjct: 121 DAIQLIKEELFPLTSLITPNLDETEVLTG-KKITTAEEMKEAARQLSEEYHTAVLVKGGH 179

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L+  +  D LFT      +   +I ++N HGTGCTLS+++A            V +AKS+
Sbjct: 180 LEGNEMQDVLFTDGNAYIYKEKKIESRNLHGTGCTLSSSIATYLALGLPMDQAVGKAKSY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +S A+     + +GHG GP+ HF 
Sbjct: 240 VSKAIDAGKEIIIGHGNGPLCHFW 263


>UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2N6_WIGBR
          Length = 272

 Score =  336 bits (862), Expect = 6e-91,   Method: Composition-based stats.
 Identities = 132/268 (49%), Positives = 198/268 (73%), Gaps = 2/268 (0%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK+I   L+IAGTDP+ GAGIQ DLKTFSALGAYG +VIT+LV+QNT+GVQS+Y++  + 
Sbjct: 1   MKKIYKILSIAGTDPTCGAGIQCDLKTFSALGAYGLTVITSLVSQNTKGVQSIYKLPINV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           + +Q++SVFSDV+ID+ KIGML ++ I+E + + +++Y I  ++LD VM +K G  LL  
Sbjct: 61  IKSQINSVFSDVKIDSIKIGMLYDSAIIETIYKEIKKYYIPWIILDPVMSSKDGSCLLKK 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            ++  ++  L P  S++TPNL E++ +L+   A+ E ++ EQG+++L  GC  VLMKGGH
Sbjct: 121 RSINKIKKLLFPISSIVTPNLKESSLILNCSIAKNESQLKEQGKAILEYGCNMVLMKGGH 180

Query: 180 LDDEQ-SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L + + S DWL ++  E +F   RI TKNTHGTGC+LS+A+AAL P+  NW +T++++KS
Sbjct: 181 LKNNKESSDWLISKNKEIKFKGVRINTKNTHGTGCSLSSAIAALMPKFCNWEETIKKSKS 240

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAWW 266
           WL  ++ +++ L +G GIGP+HHF+  W
Sbjct: 241 WLEMSIYKSNKLNIGKGIGPIHHFYNLW 268


>UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingobacterium
           spiritivorum RepID=C2FVP8_9SPHI
          Length = 278

 Score =  333 bits (854), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 107/262 (40%), Positives = 155/262 (59%), Gaps = 2/262 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  L+IAG D SGGAGIQAD+KTFSALG Y  SV+TAL  QNT+GV+S+Y I    V  Q
Sbjct: 8   IPVLSIAGFDGSGGAGIQADMKTFSALGCYATSVLTALPVQNTQGVRSIYPIPDVAVREQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + ++  D+     KIGM+  +++V+ + + L  Y    VV D VM+A SG  L+  S + 
Sbjct: 68  IQTILDDIFPKAIKIGMVHTSELVQIITDTLGLYPATPVVFDPVMVATSGHKLIEESTIL 127

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           TL  +L P  +++TPN+ EAA L +    +T  +M   G  +L +GC +VL+KGGHL   
Sbjct: 128 TLVEQLFPITTVLTPNMDEAAILAEM-EVKTLDDMYIAGEKILKLGCQSVLLKGGHLQTS 186

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
                 F + G  Q F   +  T NTHG+GCTLS+A+A+   R  + AD V+  + ++  
Sbjct: 187 MLTSLFFDQSGSVQTFEFEKFETNNTHGSGCTLSSAIASYLARGESLADAVRLGQDYVHQ 246

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+     ++ G G GP++HF  
Sbjct: 247 AILNGKDVQTGKGNGPLNHFFN 268


>UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria RepID=A1W069_CAMJJ
          Length = 270

 Score =  330 bits (846), Expect = 4e-89,   Method: Composition-based stats.
 Identities = 106/264 (40%), Positives = 158/264 (59%), Gaps = 4/264 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           + I  LTIAG+D SGGAGIQADLKTFSA   +G SV+ ++VA+NT  V SV+ I    V 
Sbjct: 7   ELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVD 66

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+ +VF D+    TKIGM+   +++  VA+ L  ++ QNVV+D VM AK+G  L+    
Sbjct: 67  EQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQEN 126

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
               +  ++    ++TPN+PEA  L        E++M++  + L ++G  AVL+KGGH +
Sbjct: 127 CDFFKQTIVKFADILTPNIPEAEFLCGFK-IANEEQMIKAAKHLCSLGAKAVLLKGGHSE 185

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            E + D L+  +        RI TKNTHGTGCTLS+A+A+   +  +    V EAK ++ 
Sbjct: 186 -ENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFYAVSEAKEYVR 244

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
           +A+    +L +G G GP +HF  +
Sbjct: 245 NAIYY--SLNLGKGCGPTNHFFKF 266


>UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella melaninogenica
           ATCC 25845 RepID=C5VH24_9BACT
          Length = 271

 Score =  329 bits (844), Expect = 7e-89,   Method: Composition-based stats.
 Identities = 117/265 (44%), Positives = 166/265 (62%), Gaps = 2/265 (0%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+ I ALTIAG+D SGGAGIQAD+KT SALG Y  +VIT++  QNT+GVQ+VY + P  V
Sbjct: 1   MRYICALTIAGSDCSGGAGIQADIKTMSALGVYAAAVITSITVQNTKGVQAVYGMNPLIV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A Q+ +V  D++ D  KIGM+ +   + A+A+ L+ Y    +V+D +M++ SG  L+   
Sbjct: 61  ADQIKAVMDDIKPDAVKIGMVNDCATIHAIADTLKFYPNIPIVIDPIMISTSGFRLMKQD 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +      LLP  +L+TPNLPEA  L +     T  +M    + +L++GC AVL+KGGH 
Sbjct: 121 TLELFCHSLLPMSTLLTPNLPEAEILSNMK-IYTIDDMDIAAQRILSLGCKAVLIKGGHA 179

Query: 181 DDEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             ++  D L+ T EG Q FT   I T+NTHGTGCTLS+A+ +   R  + AD +  AK++
Sbjct: 180 KGDRKVDRLYTTNEGVQTFTHKTIDTRNTHGTGCTLSSAITSFIARRLDLADAIAAAKNY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFHA 264
           LS AL     + +G G GPV+H   
Sbjct: 240 LSQALEAGKDIHIGEGHGPVNHLFN 264


>UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphomethylpyrimidine kinase
           n=15 Tax=Bacteria RepID=C1AE24_GEMAT
          Length = 493

 Score =  328 bits (843), Expect = 8e-89,   Method: Composition-based stats.
 Identities = 147/265 (55%), Positives = 178/265 (67%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +  NALTIAG+DPSGGAGIQADLKTF+A   YG + +TAL AQNTRGV  V+ + P FV 
Sbjct: 227 RIPNALTIAGSDPSGGAGIQADLKTFAAQRVYGMAALTALTAQNTRGVAGVHVVPPVFVL 286

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+S+F D+RID  KIGM+A  DI   VA+ L+      VVLD VM+AK G  LL P A
Sbjct: 287 QQLESLFDDIRIDAVKIGMIATADIATTVADVLEERMRGPVVLDPVMIAKGGAELLRPDA 346

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V  +R+RLLP  ++ITPNL EAA LL+ P A T  EM  Q   L A+G  AVL+KGGHL 
Sbjct: 347 VDAVRTRLLPLATVITPNLAEAAHLLNMPMASTRAEMETQATLLRALGPQAVLLKGGHLT 406

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           +E+SPD L T +G   F  PR+ T NTHGTGCTLSAA+AA      N    V+ AK +++
Sbjct: 407 EERSPDCLVTSDGVHWFDGPRVATANTHGTGCTLSAAIAAGLAGGGNLLTVVRTAKQYVT 466

Query: 242 SALAQADTLEVGHGIGPVHHFHAWW 266
            A+A A  L VGHG GP HHFH  W
Sbjct: 467 DAIASAHRLTVGHGHGPTHHFHNLW 491


>UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular organisms
           RepID=A8MBV4_CALMQ
          Length = 436

 Score =  328 bits (841), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 111/263 (42%), Positives = 163/263 (61%), Gaps = 7/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +K   ALTIAG D  GGAGI ADLKTF A+G YG   +TA+ AQNT GV++V  IEP  V
Sbjct: 3   VKLPKALTIAGLDSGGGAGITADLKTFHAMGVYGMVALTAVTAQNTLGVKAVQEIEPSIV 62

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+++V  D+ +D  K GML+ + I+E+VA+ ++R+    +V+D VM AKSGDPL+   
Sbjct: 63  EAQINAVAEDIGVDAAKTGMLSSSPIMESVAKVVRRWGF-PLVVDPVMYAKSGDPLMRQD 121

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGH 179
           A+ TLR  ++P   ++TPN+PEA AL      R   +     + +        V++KGGH
Sbjct: 122 AIDTLRRTIIPLAKVVTPNIPEAEALSGV-SIRNLNDAKAAAKRIAEEFHPEIVIVKGGH 180

Query: 180 LDDEQSPDWLF--TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           L   +S D ++       +  +APRI T NTHGTGC+ SAA+AA   +  +  D++++AK
Sbjct: 181 LTGAESIDVVYFRDNGEYRELSAPRISTGNTHGTGCSFSAAIAAGLAKGMSPWDSIKQAK 240

Query: 238 SWLSSALAQADTLEVGHGIGPVH 260
             ++ A+    +L +GHG GPV+
Sbjct: 241 ELITMAIQY--SLPLGHGHGPVN 261


>UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular organisms
           RepID=A1K3Q3_AZOSB
          Length = 284

 Score =  326 bits (837), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 135/271 (49%), Positives = 170/271 (62%), Gaps = 8/271 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
            N L+IAG DPSGGAGI AD+KTFSALGAYGC VI AL AQNT+ V  V+    DF+  Q
Sbjct: 12  PNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD++F+DV +  TKIGML   ++   VA+RL  +Q  NVVLD VM+AKSGD LL+ +A+A
Sbjct: 72  LDTLFADVAVHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIA 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGC----GAVLMKGGH 179
            +R  L PQ  +ITPNLPEA  LL+     + +EM      L  +        V++KGGH
Sbjct: 132 MMREALFPQSFMITPNLPEAGVLLEQRAPESVKEMYRAAERLRELLPLSSERWVMLKGGH 191

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALR---PRHTN-WADTVQE 235
           L   +  D LF  +      APRI T+NTHGTGCTLS+A+AAL              V++
Sbjct: 192 LPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAGGFRGVEAAVRQ 251

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           A+ WL  A+A +  L VG G GPVHHFHA W
Sbjct: 252 ARQWLLGAIAHSGDLGVGSGHGPVHHFHALW 282


>UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0EZ09_9FIRM
          Length = 483

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 106/272 (38%), Positives = 155/272 (56%), Gaps = 13/272 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D SGGAGIQAD+KT +    Y  + ITAL AQNT G+  +  +  +F 
Sbjct: 218 MK--TVLTIAGSDSSGGAGIQADIKTLTVHKVYAMTCITALTAQNTVGITGIMPVPAEFF 275

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++S+F+D++ D  KIGM+A  +  E +AE L++Y I+NVV D VM++ SG  L+  +
Sbjct: 276 KKQMESIFTDIKPDAVKIGMIASKEQAEIIAEYLEKYSIKNVVADPVMISTSGTVLVEET 335

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L  +L P+VSL+TPN+PE   L        ++   E  + +      AVL KGGH 
Sbjct: 336 TRKILYEKLYPKVSLLTPNIPETEFLSGIK-ITDKKTREEAAKVIADRWNCAVLSKGGHS 394

Query: 181 DDEQSPDWLFT-------REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
           + E + D L+        +E    F   RI   NTHGTGCTLS+A+AA   +     ++V
Sbjct: 395 E-ENADDLLYESFLQEEKKEKAVWFPEERIDNPNTHGTGCTLSSAVAANLAKGFPVEESV 453

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           ++AK ++S A+     L +G G GP++H    
Sbjct: 454 KKAKVYISGAIRAM--LNLGQGNGPLNHMWDL 483


>UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyrimidine
           phosphokinase) n=3 Tax=Pasteurellaceae
           RepID=Q0I130_HAES1
          Length = 270

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 117/266 (43%), Positives = 162/266 (60%), Gaps = 7/266 (2%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M ++  ALTIAG+D SGGAGIQADLKTF     +G + ITA+ AQN+ GV  ++ + P  
Sbjct: 1   MSKVAIALTIAGSDNSGGAGIQADLKTFQMQKVFGMTAITAVTAQNSLGVYDIHPVPPAT 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           + +QL ++  D ++   KIGML   DI++ VAE L++Y    +VLD VM AK G  LL P
Sbjct: 61  IRSQLKAIAEDYQVSALKIGMLGNVDIIQCVAEELEKYDFGKIVLDPVMYAKGGAALLEP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           +AV+TLRS LLP+  +ITPNLPE AAL D          L     LL MG   V++KGGH
Sbjct: 121 AAVSTLRSLLLPKTDVITPNLPEVAALTDIHVVDDHTARL-AAEKLLVMGVKNVVIKGGH 179

Query: 180 LDD---EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
             +   E   DWLFT+    +  +PR  T +THGTGCT SA + A   +  +    V+ A
Sbjct: 180 SQNSQSEICRDWLFTQHSSLKLDSPRFDTPHTHGTGCTFSACIVAELAKGESVQSAVRTA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHF 262
           K ++S++++    L +GHG GP +H+
Sbjct: 240 KDFISASISH--PLNIGHGHGPTNHW 263


>UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli RepID=Q5HMC8_STAEQ
          Length = 273

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 110/265 (41%), Positives = 157/265 (59%), Gaps = 6/265 (2%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M +   ALTIAGTDP+GGAG+ ADLK+F A G YG + IT++VAQNT GVQ ++ +E  +
Sbjct: 1   MNKPKIALTIAGTDPTGGAGVMADLKSFHACGVYGMATITSIVAQNTLGVQHIHNLESSW 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V  QLDSVF D      K GM+A    +E +   L+ +     V+D VMLAKSGD L+  
Sbjct: 61  VKEQLDSVFDDELPQAIKTGMIATKKTMELIQSYLKEHSNIPYVIDPVMLAKSGDSLMDE 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGG 178
           +    L+S LLP   ++TPN+PEA  +        E+ + + G+  +  +G   V++KGG
Sbjct: 121 NTKNHLQSTLLPLADVVTPNIPEAEEITGIK-INDEESIRKAGQIFINEIGSKGVVIKGG 179

Query: 179 HLDD-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H  D   + D+LFT+     F   R  TK+THGTGCT SA + A   +  +  D V++AK
Sbjct: 180 HSADLNNAKDFLFTKNETYTFENKRFDTKHTHGTGCTFSAVITAELAKGRSIKDAVKKAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++S ++      E+G G GPV+HF
Sbjct: 240 EFISLSIEHTP--EIGKGRGPVNHF 262


>UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Bacteria RepID=B7GEW3_ANOFW
          Length = 293

 Score =  323 bits (828), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 99/243 (40%), Positives = 145/243 (59%), Gaps = 3/243 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF  L  +G S ITA+ AQNT GVQ VY +  + +  Q+DS+  D+  +  K G
Sbjct: 50  IQADLKTFHQLHVFGMSAITAVTAQNTLGVQGVYPLPIEAIEKQIDSIAIDLPPNAVKTG 109

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA ++++Y    VV+D VM+AK G PLL   AV  L+  +LP   ++TPN
Sbjct: 110 MLFSEEIIELVARKIKQYGWVRVVVDPVMIAKGGAPLLKQEAVKALQRHMLPLARVLTPN 169

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L +     T ++  E  + L  MG   V+MKGGH + E+  D L+  E    + 
Sbjct: 170 IPEAEVLTNM-RIETFEQRKEAAKKLHDMGVQYVVMKGGHGEGEELVDLLYDGEQFYEWK 228

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + R+ TK+THGTGCT +AA+ A   +     + V  AK ++ +A+ Q  TL++G G GP 
Sbjct: 229 SRRVHTKHTHGTGCTFAAAITAELAKGKTVYEAVNIAKQFIQAAIEQ--TLQIGGGHGPT 286

Query: 260 HHF 262
           +H+
Sbjct: 287 NHW 289


>UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria RepID=A7I3E2_CAMHC
          Length = 257

 Score =  322 bits (826), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 107/262 (40%), Positives = 157/262 (59%), Gaps = 7/262 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  LTIAG+D SGGAGI+AD+KTF A G YG SVIT++VA+NT  V + Y +    V  Q
Sbjct: 2   IPVLTIAGSDASGGAGIEADIKTFCAHGLYGMSVITSVVAENTFRVINAYDMSAQAVGDQ 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +++VF D+     KIGML   +I++ VAE+L ++  +NVVLD VM AK+G  L+S     
Sbjct: 62  IEAVFEDIVPKAVKIGMLPNAEIMQIVAEKLAKFSAKNVVLDPVMQAKNGFNLMSE--RE 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L S++L  + +ITPN+PEA  L +      E +M      +   G  +VL+KGGH +  
Sbjct: 120 NLLSKMLGVIDIITPNIPEAEILTN-TEISNENDMKNAALIIAKKGAKSVLIKGGHKNG- 177

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+L+       +    I TKNTHGTGCTLS+A+A+         + V+ AK ++   
Sbjct: 178 -TSDFLYFEGKFFEYKTKFINTKNTHGTGCTLSSAIASNLALGRKMNEAVENAKKYIQGT 236

Query: 244 LAQADTLEVGHGIGPVHHFHAW 265
           +    +L++GHG GP++HF+  
Sbjct: 237 IEN--SLDLGHGAGPLNHFYNI 256


>UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria RepID=B0KBA9_THEP3
          Length = 264

 Score =  322 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 102/246 (41%), Positives = 153/246 (62%), Gaps = 4/246 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTFSA G YG SVIT++ AQNT GV  +  I PD V  Q+ ++F D+  D  KIG
Sbjct: 18  IQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMKAIFEDLYPDAVKIG 77

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           M++   I++ +A+ L+ Y ++N+VLD VM++KSG  LL P AV  L+  L+P   ++TPN
Sbjct: 78  MVSNESIIKMIAKGLKDYNVKNIVLDPVMISKSGSYLLKPEAVEALKKELIPLSLVVTPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L EA  L+     +   +M E  + +L  G   V++KGGHL  + + D  +  +     T
Sbjct: 138 LMEAGELIG-KEIKNVSDMKEAAKKILDYGAKTVIVKGGHLTGD-ALDVFYDGKEFYEIT 195

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + RI TKNTHGTGCT S+A+AA      +  ++++ AK++++ A+    +L +GHG+GP 
Sbjct: 196 SERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAIKH--SLAIGHGVGPT 253

Query: 260 HHFHAW 265
           +HF   
Sbjct: 254 NHFWNI 259


>UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=85
           Tax=Bacilli RepID=THID_STAAS
          Length = 276

 Score =  321 bits (823), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 112/267 (41%), Positives = 162/267 (60%), Gaps = 5/267 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +K   ALTIAGTDP+GGAG+ ADLK+F + G YG  V+T++VAQNT GVQ ++ +   +V
Sbjct: 2   IKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQHIHNLNHQWV 61

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QLDSVF+D      K GM+A  D +E +   L +++    V+D VMLAKSGD L+   
Sbjct: 62  DEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDND 121

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGH 179
               L+  LLP   ++TPNLPEA  +       +E+++++ GR  +  +G   V++KGGH
Sbjct: 122 TKQNLQHTLLPLADVVTPNLPEAEEITGLT-IDSEEKIMQAGRIFINEIGSKGVIIKGGH 180

Query: 180 LDD-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            +D + + D+LFT EG Q F   R  TK+THGTGCT SA + A   +     + V +AK 
Sbjct: 181 SNDTDIAKDYLFTNEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRRLFEAVHKAKK 240

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           ++S ++      E+G G GPV+HF   
Sbjct: 241 FISMSIQYTP--EIGRGRGPVNHFAYL 265


>UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 cluster
           RepID=Q1V215_PELUB
          Length = 270

 Score =  321 bits (823), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 99/266 (37%), Positives = 157/266 (59%), Gaps = 4/266 (1%)

Query: 1   MK-RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK +   L IAG+D SGGAGIQAD+KT +ALG+Y  + ITA+  QNT GV+S+  I+P  
Sbjct: 1   MKPKSKILVIAGSDSSGGAGIQADIKTITALGSYAMTAITAVTIQNTTGVKSIVPIDPKE 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           ++ Q++    D++ D  KIGML  T ++++V   L   +++ ++LD VM+AK G  L+  
Sbjct: 61  ISNQIEFTSKDIKPDAIKIGMLHSTKVIKSVIHSLNLIKVKKIILDPVMVAKGGAKLIDD 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  L++ L+ +VSLITPN+PEA  L      RT+++M+     L+ +G   V +KGGH
Sbjct: 121 KAIQLLKNELIKKVSLITPNIPEAEILTK-TKIRTKEDMIFAASILIKLGAKNVFIKGGH 179

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L+ +   D    +         RI T+NTHGTGCTLS+A++           + + A  +
Sbjct: 180 LESKIVQDIFVNKNEIFIIKNKRITTRNTHGTGCTLSSAISTFFSCGKTLKRSCELATKY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           + +++     L+ G G GP++H  + 
Sbjct: 240 VHNSINS--NLKFGKGHGPINHLSSV 263


>UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquificales
           RepID=C0QRY4_PERMH
          Length = 262

 Score =  320 bits (822), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 101/262 (38%), Positives = 152/262 (58%), Gaps = 5/262 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            AL+IAG+D SGGAGIQADLK FSA G YG S +T++  QNT GV+  + +  D +  Q+
Sbjct: 4   KALSIAGSDNSGGAGIQADLKVFSAFGVYGMSAVTSVTVQNTLGVKGSHPVPSDILFEQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D+ +D  K GML   + V AV + ++  +++N V DTV+ +K+G  LL  SA+ T
Sbjct: 64  KAVVEDIGVDAFKTGMLQTEENVLAVYQAVKDLRMKNFVADTVIRSKNGKYLLDKSAIET 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-DE 183
              R++P   +ITPN+ EA  L      R+  +M+   + L  MG  AV++KGGHL   +
Sbjct: 124 FIKRIVPLADIITPNIDEAEVLTGI-EIRSVDDMIRAAKELYRMGSSAVVVKGGHLPQGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D  +  +       P + TKNTHGTGCT SAA+ A   +  +    V+ A+S++  A
Sbjct: 183 RIVDIFYNGD-LYTLEYPYVRTKNTHGTGCTFSAAITACLAKGYDHLKAVRVARSYIQGA 241

Query: 244 LAQADTLEVGHGIGPVHHFHAW 265
           +    +L +G G G ++HF   
Sbjct: 242 IEN--SLSIGKGTGSLNHFWTV 261


>UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroidales
           RepID=B6YRS2_AZOPC
          Length = 270

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 117/271 (43%), Positives = 171/271 (63%), Gaps = 7/271 (2%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L++AG+DPSGGAGIQADLKT SA G YG +VITA+V +NT  V++++ I   F
Sbjct: 1   MKHYKRVLSVAGSDPSGGAGIQADLKTVSACGCYGTTVITAIVDENTISVKNIHPIPISF 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLS 118
           V  Q+ SV +D+  D+ KIGML  ++++ AV      Y  I+N+VLD VM+A SGD LLS
Sbjct: 61  VIGQIHSVLNDIGTDSVKIGMLYSSELIRAVRNSFLTYNTIRNIVLDPVMVATSGDFLLS 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKG 177
            +++ TL++  +P V ++TPN+ EA  LLD       ++ L   + L + G   +VL+K 
Sbjct: 121 NNSIDTLKNEFIPFVRVVTPNIQEAEILLDRT-ITNAEDFLLAVKDL-SFGRKVSVLLKA 178

Query: 178 GHLDDEQSPDWLFTREGEQR--FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           GHL++E   D  +  E ++   F+ PRI TKNTHGTGCTLS+A+AA         D +++
Sbjct: 179 GHLEEETLTDVFYNAETDEILYFSHPRIKTKNTHGTGCTLSSAIAAYLACGCILNDAIRK 238

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           A++++  A+       +G G GPVHHF  +W
Sbjct: 239 AETYIIQAIRVGSKYSIGKGHGPVHHFSHFW 269


>UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=29
           Tax=Bacteria RepID=THIED_GEOSL
          Length = 490

 Score =  317 bits (812), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 112/245 (45%), Positives = 153/245 (62%), Gaps = 3/245 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT + LG+YG SV+TAL AQNTRGV  ++ + P FVA QLD+VFSD+ +D  K G
Sbjct: 242 IQADLKTVTLLGSYGSSVLTALTAQNTRGVSGIHGVPPAFVADQLDAVFSDIPVDVVKTG 301

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   + + A+A +L  Y+ + VV+D VM+AK G  L+   AV+ L+ RL P   L+TPN
Sbjct: 302 MLFSAETIVAIAAKLTEYRRRMVVVDPVMVAKGGANLIDRGAVSVLKERLFPLAYLVTPN 361

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L  A +   E+ M E  R L  +G   VL+KGGHL    S D LF      RF 
Sbjct: 362 IPEAERLTGA-NISDEESMREAARRLHRLGARNVLLKGGHLLAGDSVDILFDGAAFHRFV 420

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +PRI++KNTHGTGCT ++A+A    +     + +  AK ++++A+  A  L  G G GPV
Sbjct: 421 SPRILSKNTHGTGCTFASAIATYLAQGDPLREAIARAKRYITAAIRLAQPL--GRGHGPV 478

Query: 260 HHFHA 264
           +H  A
Sbjct: 479 NHILA 483


>UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=5
           Tax=Bacteroidales RepID=A6LAW4_PARD8
          Length = 282

 Score =  316 bits (811), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 97/246 (39%), Positives = 148/246 (60%), Gaps = 2/246 (0%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KTFS+LG +G S ITA+ AQNT+GV+ +  I P+ +  Q++++  D  +D  KIG
Sbjct: 26  IQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILRGQIEAILEDFIVDAVKIG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   D V+ V+E L  ++  +++LD VM++ SG  LL   A+ T+   L P+ +L+TPN
Sbjct: 86  MLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDAIRTIMDELFPKATLLTPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLF-TREGEQRF 198
           +PE   L        E ++L   R L   GC A+L+KGGH+   ++ D LF         
Sbjct: 146 IPETEYLSGIK-INNEADILCAARKLQEKGCNAILIKGGHIPGVETVDRLFINENNPICL 204

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            +P + T NTHGTGCTLS+A+AA      +  + V+ AK ++++AL     + +G G GP
Sbjct: 205 ASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVRLAKEYMNNALVHGANVCMGKGHGP 264

Query: 259 VHHFHA 264
           V+HF +
Sbjct: 265 VNHFFS 270


>UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomonas sputigena ATCC
           35185 RepID=C9LV61_9FIRM
          Length = 296

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 110/264 (41%), Positives = 156/264 (59%), Gaps = 5/264 (1%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK I   LTIAG+DPSGGAGIQAD+KT +A   Y  ++ TAL  QNT G++  + I PDF
Sbjct: 34  MKDIRKVLTIAGSDPSGGAGIQADIKTITAHKMYAMNISTALTVQNTTGIRDTFVIPPDF 93

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +A QLD+++ D+R D  KIGM+A   IV  +AE+L+    +N+VLD V+ + SG  L++ 
Sbjct: 94  IAEQLDAIYDDIRPDAVKIGMVANDAIVHTIAEKLREKDAKNIVLDPVIASTSGCDLITS 153

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +  +   LLP V ++TPNLPEAAA+        E  ML+  + L      AVL+KGGH
Sbjct: 154 DTLFAMVDELLPLVDIVTPNLPEAAAITGVA-ITDEDSMLKAAKVLTERFPIAVLIKGGH 212

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L  E + D L+     + +   RI  +NTHGTGC LS A+A            V++AK++
Sbjct: 213 LV-ESADDLLYADGKARWYKQTRIDNENTHGTGCALSTAIACGLAAGKPLTIAVEDAKAY 271

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           ++ A+     L +G G GP+ H  
Sbjct: 272 ITGAIRAG--LNIGKGRGPLLHMW 293


>UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsiella grylli
           RepID=A8PMT6_9COXI
          Length = 278

 Score =  315 bits (807), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 114/259 (44%), Positives = 161/259 (62%), Gaps = 2/259 (0%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            ++IAGTDPSGGAGIQAD+K  SA G+Y  S+IT LVAQNT+ V S+  I  DF+  Q+D
Sbjct: 10  VVSIAGTDPSGGAGIQADIKAISATGSYAASIITVLVAQNTQAVISLQDIPLDFIQQQID 69

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +VF+D+ I+  K+GML    I+  +   L++YQ   +VLD VM+ ++G PLL P A+  L
Sbjct: 70  AVFTDLSINAVKLGMLYHEGIIRLIRHNLKKYQPPFIVLDPVMITQTGHPLLKPQAIQVL 129

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            + L P  +LITPN+PEA +LL+         M +    L      +VL+KGGH   + S
Sbjct: 130 ATDLFPLATLITPNIPEAESLLNLKIIDATT-MQKAAVLLATRYKVSVLLKGGHSPYDAS 188

Query: 186 PDWL-FTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             +  F+++    F   RI TKNTHGTGCTLSAA+A+   +  N  + +  AK++L+  L
Sbjct: 189 DIFYDFSQKQIHYFKRARINTKNTHGTGCTLSAAIASYLAQGLNVVEAIFHAKNYLTQCL 248

Query: 245 AQADTLEVGHGIGPVHHFH 263
             A  L +G G GPV+HF+
Sbjct: 249 LAAKDLHLGQGQGPVNHFY 267


>UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria RepID=B7VS71_VIBSL
          Length = 302

 Score =  314 bits (806), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 129/262 (49%), Positives = 178/262 (67%), Gaps = 1/262 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D  GGAGIQAD+K  SA G++ CSVITA+ +QNT+GV +++ I  D VA+Q
Sbjct: 35  PIVLTIAGSDSGGGAGIQADIKAMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVASQ 94

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD+VF+D+ I   K+GMLA++ I++ VA+++++Y+ +++V+D VM+A SGD LL  SA+ 
Sbjct: 95  LDAVFTDLNIVAVKVGMLADSQIIKVVADKIKQYRPKHLVIDPVMVATSGDLLLENSAIT 154

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-D 182
           TL+  L+P   +ITPNLPE AAL   P   +E EM      L A+G  AVL+KGGHL+ D
Sbjct: 155 TLKQELIPLADIITPNLPEGAALTGKPVPESEAEMQGMIEDLRALGAKAVLLKGGHLEKD 214

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E S D L         +A R  TKNTHGTGCTLS+A+A+   +    A+ V   K ++S 
Sbjct: 215 ENSNDLLILPTTSALISAKRFPTKNTHGTGCTLSSAIASFLAQGNTLAEAVDLGKQYISR 274

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+A AD L+VG G GPV+HF A
Sbjct: 275 AIAHADELQVGQGHGPVNHFFA 296


>UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=A5VNE7_BRUO2
          Length = 304

 Score =  314 bits (805), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 138/264 (52%), Positives = 181/264 (68%), Gaps = 2/264 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              +TIAG+D SGGAGIQADLK FSALG YG SVI A+  QNTR V +V+ + P  VA Q
Sbjct: 34  PICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQ 93

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+VFSD+ +   KIGM++  + +EA+A  L  +    +VLD VM+AKSGD LLS +A++
Sbjct: 94  IDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFS-GPIVLDPVMVAKSGDRLLSETAIS 152

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           +LR +LLP  +L+TPN PEAA LLD   A ++ E  EQGR+LL +G  AVLMKGGH +  
Sbjct: 153 SLRKKLLPLATLLTPNRPEAACLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGA 212

Query: 184 QSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
              D L  R+    R  APRI+T NTHGTGCTLS+A+AA   R+ +    + +A ++L  
Sbjct: 213 ICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGLSRNLSLETALAQAHAYLQG 272

Query: 243 ALAQADTLEVGHGIGPVHHFHAWW 266
           A+  AD+L+VG G GPVHHFHA W
Sbjct: 273 AIRAADSLKVGQGHGPVHHFHALW 296


>UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
           n=2 Tax=Schizosaccharomyces RepID=THI22_SCHPO
          Length = 551

 Score =  312 bits (800), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 98/276 (35%), Positives = 145/276 (52%), Gaps = 18/276 (6%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             +LTIAG+D SGGAGIQADLKT ++LG YG S IT LVA+N  GV SV  + P FV +Q
Sbjct: 36  PVSLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVESQ 95

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D    D+     K GML   +IV+AVA   +++    +V+D VM+A SGD L++   V+
Sbjct: 96  IDCCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIVS 155

Query: 124 TLRSRLLPQVSLITPNLPEAAAL-----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
            L   LLP   L+TPN+PEA  L     LD  +  +  +M      +  +G   VL+KGG
Sbjct: 156 VLNEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKGG 215

Query: 179 HL------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRH 226
           H+            +D +  D L+       F++  +     HGTGCTLS+A+A+     
Sbjct: 216 HMPVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAWE 275

Query: 227 TNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHF 262
            +  + VQ    ++  A+  +  +        ++H 
Sbjct: 276 HSLTEAVQFGIDYVHGAITHSPPINNCS-TNILNHM 310


>UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=348
           Tax=Bacteria RepID=THID_RHIME
          Length = 266

 Score =  312 bits (800), Expect = 9e-84,   Method: Composition-based stats.
 Identities = 122/247 (49%), Positives = 163/247 (65%), Gaps = 1/247 (0%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTFSALG YG SVITA+ AQNTRGV +V  +  + V+AQ+D+VFSD+ +   KIG
Sbjct: 19  IQADLKTFSALGVYGASVITAITAQNTRGVTAVEDVSAEIVSAQMDAVFSDLDVKAVKIG 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           M++  + + A+A+ L+R+  +  V+D VM+A SGD LL P AVA L   LLP   ++TPN
Sbjct: 79  MVSRRETIAAIADGLRRFG-KRAVVDPVMVATSGDALLRPDAVAALIEELLPLALVVTPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L EAA +     A  E EM  Q  +++  G  AVL+KGGHL  +++ D  F  +   R  
Sbjct: 138 LAEAALMTGRAIAGDEAEMARQAEAIMRTGAHAVLVKGGHLKGQEATDLFFDGDTLVRLP 197

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           A RI T+N HGTGCTLSAA+AA   +     + V  AK++L +A++ AD LE+G G GPV
Sbjct: 198 AGRIETRNDHGTGCTLSAAIAAGLAKGVPLIEAVSAAKAYLHAAISAADRLEIGQGRGPV 257

Query: 260 HHFHAWW 266
           HHFH WW
Sbjct: 258 HHFHRWW 264


>UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Aquifex aeolicus RepID=THID_AQUAE
          Length = 255

 Score =  311 bits (797), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 99/251 (39%), Positives = 143/251 (56%), Gaps = 1/251 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           + AL+IAG D SGGAG  AD++TF   G YG +VITAL  QNT+ V  V+ I PD V  +
Sbjct: 1   MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEE 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L ++F D  I   KIGMLA  +I E V E L+  +   +VLD V  +KSG  LLS   V 
Sbjct: 61  LKAIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVE 120

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L+S  +  V LITPN+PEA  L      ++ +++    + + ++G  +VL+KGGHL   
Sbjct: 121 FLKSEFIKIVDLITPNVPEAEILCG-EEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGN 179

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L+  +    F AP+I  K   GTGC  S+A+ A   RH +    ++ AK +++ A
Sbjct: 180 YAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEA 239

Query: 244 LAQADTLEVGH 254
           +  +  L  G+
Sbjct: 240 IKNSKKLGKGY 250


>UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantella formatexigens DSM
           14469 RepID=C6LBN3_9FIRM
          Length = 330

 Score =  311 bits (797), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 119/307 (38%), Positives = 160/307 (52%), Gaps = 53/307 (17%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D SGGAGIQADLKT  A   YG SVITAL AQNT GV  +    P+FVA Q+
Sbjct: 4   KVLTIAGSDCSGGAGIQADLKTMMAHDVYGMSVITALTAQNTTGVYGILETPPEFVAQQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D VF D+R D  KIGM+ +  I+E +AE+L++YQ +N+V+DTVM++ SG  L+S  A+ T
Sbjct: 64  DCVFQDIRPDAVKIGMVPDCGIMEVIAEKLKQYQAENIVIDTVMISTSGHRLMSEQAMQT 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLD------------------------------------ 148
              +LLP  ++ITPNLPEA AL                                      
Sbjct: 124 YTEKLLPLAAVITPNLPEAEALYQYETGAGIRAEKGSYQNETGAGIRAEKGSYQNETGAG 183

Query: 149 --------------APHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREG 194
                           HA +E++M      +     GA+L+KGGHL  + + D L     
Sbjct: 184 IRAEKGSFQNETGAGFHAGSEEDMKRMAEKIAGRYGGALLIKGGHLCGD-AADLLCENGN 242

Query: 195 EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
              F   RI   N+HGTGCTLS+A+A    +     ++V  AK +++ AL     L +G 
Sbjct: 243 FHWFRTERIQNPNSHGTGCTLSSAIACNLAKGKTVYESVYAAKEYVTDALRAG--LNLGR 300

Query: 255 GIGPVHH 261
           G GP+ H
Sbjct: 301 GSGPLAH 307


>UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM
          Length = 269

 Score =  310 bits (796), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 116/265 (43%), Positives = 162/265 (61%), Gaps = 6/265 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     LTIAG+D  GGAGIQADLKTF   G +G SVITA+ AQNT GV  ++ I    +
Sbjct: 1   MVIPQVLTIAGSDSGGGAGIQADLKTFQMRGVFGTSVITAVTAQNTLGVFDIHPIPLASI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQL +V  D  I   KIGML  T+I++ VA+ L++YQ  ++VLD VM+AK G  LL  S
Sbjct: 61  QAQLRAVAKDFSISAVKIGMLGNTEIIQCVADCLEQYQFSHIVLDPVMIAKGGATLLEQS 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AVA L++ +LP+  LITPN+PEA  +      + E ++    +    +G   V++KGGH 
Sbjct: 121 AVAALKNLILPKACLITPNIPEAERITG-TQIKNEADIFNAAQIFHELGANTVVIKGGHH 179

Query: 181 DDEQS---PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           ++ QS    DW+FT++G     APR  T +THGTGCT SA L A   +       V+ AK
Sbjct: 180 NNSQSKLCKDWVFTQKGYFTLEAPRFATPHTHGTGCTFSACLTAELAKGKPVEQAVRTAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
           +++++A+     L +GHG GP +H+
Sbjct: 240 NYITAAI--GHPLNIGHGHGPTNHW 262


>UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agaricales
           RepID=A8NYV6_COPC7
          Length = 556

 Score =  310 bits (795), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 118/311 (37%), Positives = 153/311 (49%), Gaps = 53/311 (17%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DPSGGAGIQADLKTF+A G YG SVIT+L AQNT GVQ V+ + PDFV  QL 
Sbjct: 9   ALTIAGSDPSGGAGIQADLKTFAAHGCYGASVITSLTAQNTTGVQGVHAVPPDFVVQQLR 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI----QNVVLDTVMLAKSGDPLLSPSA 121
            VF D+ I   K GML +  I   VA+ L+  Q       VV D V ++ SG  LL P A
Sbjct: 69  MVFDDIDIKAIKTGMLYDAVIAAEVAKVLKERQAAGKLAPVVCDPVCVSTSGHTLLKPDA 128

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAP----HARTEQEMLEQGRSLLAMGCGAVLMKG 177
           +  L S++ P  +LITPN PE   LL  P       +  +M      L      AVL+KG
Sbjct: 129 LDVLVSQVFPLTTLITPNKPETELLLKTPNSEVKIESLADMYTAAVELSKKTSTAVLVKG 188

Query: 178 GH-----------------------------------------LDDEQSPDWLFTREGE- 195
           GH                                         L+ E   D L+  + + 
Sbjct: 189 GHVVSSLKNLEEITQKHSNVEVVKQNLYDENMEILLVGRDPKELNPEIVVDLLYQPDTQS 248

Query: 196 -QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
              +  PRI + +THGTGCTLSAA+A+   +  +  D V +   +    +A A    +G 
Sbjct: 249 AVVYARPRIESTSTHGTGCTLSAAIASGLAQGLSLKDAVAQGALYTHFGIATAQ--PIGK 306

Query: 255 GIGPVHHFHAW 265
           G GP++H H  
Sbjct: 307 GYGPLNHLHCV 317


>UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria RepID=A1A2J4_BIFAA
          Length = 280

 Score =  310 bits (794), Expect = 4e-83,   Method: Composition-based stats.
 Identities = 112/276 (40%), Positives = 151/276 (54%), Gaps = 16/276 (5%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+D SGGAGIQADLKT  A G +G + I AL AQNT GV  V    P+ +AAQ
Sbjct: 6   PPVLSIAGSDSSGGAGIQADLKTMLANGVFGMTAIAALTAQNTTGVTMVTNTPPEMLAAQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+VF D+     KIGM++  +++  +A+RL  +  +NVVLD VM+A SG  L+   A+A
Sbjct: 66  IDAVFEDIPPVAVKIGMVSSAELITVIADRLTAHNAKNVVLDPVMVATSGAKLIEDDAIA 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLD--------------APHARTEQEMLEQGRSLLAMG 169
            L S+L P  ++ITPN+PE   L D                   TE +M+  G  L    
Sbjct: 126 ALTSKLFPLATVITPNMPETQVLCDLAVEQGAGAIDYENGESISTENDMVTAGHLLAGHF 185

Query: 170 CGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNW 229
             AVL+KGGH   + S   +        F + RI   NTHGTGCTLS+A+A+        
Sbjct: 186 GCAVLVKGGHGTHDASDVLVEPDGKITWFRSRRINNPNTHGTGCTLSSAIASHLALGEAL 245

Query: 230 ADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
              V  AK +L+ AL     L++GHG GP+ H   W
Sbjct: 246 PTAVDHAKLYLTGALEA--QLDLGHGSGPMDHAWKW 279


>UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=1
           Tax=Picrophilus torridus RepID=Q6KZH7_PICTO
          Length = 256

 Score =  309 bits (793), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 93/257 (36%), Positives = 148/257 (57%), Gaps = 4/257 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +T+A TD  GGAG+ ADLKT +AL  +G +VI +L AQN+  V+S+Y +   F+  Q   
Sbjct: 1   MTVASTDSGGGAGVMADLKTMTALKVFGTAVIVSLTAQNSVSVRSIYELPEQFIRDQFYE 60

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + SD+  D  K GML   +I+  V + ++ Y ++N+V+D VM++K+G  LL   A+  L 
Sbjct: 61  ILSDIGTDAAKTGMLFSENIINTVYDEMKSYNVKNIVIDPVMVSKTGARLLKEDAIKALV 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           ++L+   +L+TPN+PEA  +          +M      +  M   +VL+KGGH++   S 
Sbjct: 121 NKLMKIATLVTPNIPEAEVITGM-RISDLNDMKNAALKIYNMTGASVLIKGGHMESSVSE 179

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D L+  E    ++  RI TKNTHGTG TLS+A+A+         D++  AK ++  A+  
Sbjct: 180 DVLYNGE-FSFYSDKRINTKNTHGTGDTLSSAIASYLAMGKTLEDSISMAKDYIEGAIIN 238

Query: 247 ADTLEVGHGIGPVHHFH 263
             +  +G G GP++HF 
Sbjct: 239 --SFPMGRGYGPLNHFW 253


>UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfatibacillum
           alkenivorans AK-01 RepID=B8FHR3_DESAA
          Length = 272

 Score =  308 bits (790), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 100/259 (38%), Positives = 144/259 (55%), Gaps = 4/259 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+D   GAGIQADLKTF+ALG YG + ITA+ AQNT GVQ    + PD + AQ
Sbjct: 7   PVVLSIAGSDSGAGAGIQADLKTFAALGVYGTTAITAITAQNTLGVQDWQEVSPDLIVAQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V SD+R    K GML   + V  VA  ++   ++N+V+D VM AK G  LL   A  
Sbjct: 67  IRAVASDMRPKAVKTGMLGGPETVRTVAREIRDLGLENLVVDPVMKAKGGKDLLLQEAYE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +   L P   ++TPNL EA+ L+     +   ++ E  +++  MG  AV++KGGH   +
Sbjct: 127 VMVKELFPLARVVTPNLDEASELVG-YDVKDLSQIKEAAKAIQTMGPAAVVIKGGHSQGQ 185

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              D L+       +   RI T ++HGTGCT ++A+AA   +     + V  AK + + A
Sbjct: 186 P-NDLLYNGSEFFEYPGKRIDTPHSHGTGCTFASAVAAGLAKGMKVREAVFRAKEFTTRA 244

Query: 244 LAQADTLEVGHGIGPVHHF 262
           +     L  GHG   V+HF
Sbjct: 245 VKHGLPLGGGHGP--VNHF 261


>UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Corynebacterium amycolatum
           SK46 RepID=UPI000185BF73
          Length = 537

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 116/261 (44%), Positives = 162/261 (62%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAG+ ADLK+ +A G YG  V+TALV+QNT GV++V+    DF+  Q
Sbjct: 13  PRVLSIAGTDPTGGAGLHADLKSIAAAGGYGMGVVTALVSQNTVGVRAVHTPPVDFLVEQ 72

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  DV ID  KIGML   ++ +AV   ++  +   VVLD VM+A SGD LL   A+ 
Sbjct: 73  LAAVTEDVTIDAVKIGMLGSRELTQAVTNWVRETKPAVVVLDPVMVATSGDRLLDEDAMD 132

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R  L+ + ++ITPN+PE A L DAP A    E++EQ     +     V+ K GHL DE
Sbjct: 133 AMRD-LVTEATVITPNVPELALLADAPEASDFTELIEQALEFASENDVIVIAKTGHLSDE 191

Query: 184 QSPDWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           ++ + +   +G+  F ++PRI T+NTHGTGC+LSAALA      +   D ++    WLS 
Sbjct: 192 EAGNAVAFPDGQVFFSSSPRIHTENTHGTGCSLSAALATRIGGGSAINDALRWTTRWLSE 251

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           ++  AD L VG G GP+ H H
Sbjct: 252 SIRFADNLNVGQGHGPIDHGH 272


>UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteobacteria
           RepID=A3P597_BURP0
          Length = 336

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 149/263 (56%), Positives = 179/263 (68%), Gaps = 2/263 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAGTDP+GGAGIQADLK FSA+ AYG + ITA+VAQNT GV+S   ++P FVA Q+
Sbjct: 74  NVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQI 133

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+VF DV +   KIGM+A   I EAVA  L R++   VVLD VM+AKSGD LL P AV  
Sbjct: 134 DAVFDDVAVHAVKIGMIATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDA 193

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R +L+P  +LITPNLPEA  LL     RT  EM      L A+G   VL+KGGHL  E+
Sbjct: 194 IRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWVLLKGGHLAGER 253

Query: 185 SPDWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           S D L          +APR+ T N HGTGCTLSAA+AAL P H +  D+V +AK++LS A
Sbjct: 254 SVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSH-SVEDSVCQAKAYLSDA 312

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           LA +  LEVG G GPVHHFHA W
Sbjct: 313 LAASGELEVGRGHGPVHHFHALW 335


>UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter rectus RM3267
           RepID=B9CYF9_WOLRE
          Length = 264

 Score =  307 bits (786), Expect = 4e-82,   Method: Composition-based stats.
 Identities = 98/266 (36%), Positives = 149/266 (56%), Gaps = 7/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L+IAG DPSGGAG+ ADLK F+A G Y    ITAL AQNT+G+  +  +E D +
Sbjct: 1   MKH--VLSIAGVDPSGGAGVIADLKVFAAHGVYAMGAITALTAQNTKGIFDMQLVECDLI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQR-YQIQNVVLDTVMLAKSGDPLLSP 119
           A Q++++F D+R+D  KIG++    I++ VA  L++   +  VVLD VM  K+GD  L  
Sbjct: 59  AKQIEAIFDDIRVDAVKIGVVPSEQIIKTVAATLRKVSNLPPVVLDPVMSCKNGDIWLEG 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           +A   + S L P  ++ITPN  EA  ++     +++ E  +  + LL  G  +V +K G 
Sbjct: 119 AAKDAIVSELFPLSTVITPNKFEAREIVK-REPKSKDEFKQACKELLKTGAKSVYLKCGD 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +    S D  +       F   RI T +THG+GC+LS+A+A+      +  ++ Q A  +
Sbjct: 178 VGG-VSLDLFYDGAEFTEFEQERIDTSSTHGSGCSLSSAIASNLALGFSLRESAQRANKY 236

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           +  A+  A    VG G  P++HFH  
Sbjct: 237 VYKAIKAA--FAVGSGCNPINHFHNV 260


>UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntrophomonas wolfei subsp.
           wolfei str. Goettingen RepID=Q0AZ88_SYNWW
          Length = 290

 Score =  306 bits (785), Expect = 5e-82,   Method: Composition-based stats.
 Identities = 120/276 (43%), Positives = 155/276 (56%), Gaps = 18/276 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++I  LTIAG+D   GAGIQAD+KT  ALGAY  SVITA+ AQNTR V +V  IE   +
Sbjct: 1   MRKI--LTIAGSDSCAGAGIQADIKTIQALGAYALSVITAVTAQNTRQVTAVREIEALVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY------------QIQNVVLDTVM 108
             QL+++FSD+R+D  KIGML     V+AV+  L  +                +V+D VM
Sbjct: 59  EKQLEAIFSDIRLDGIKIGMLGRAGTVQAVSNFLASFFQAGAFWEKQLKNSLPLVVDPVM 118

Query: 109 LAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAM 168
           +AKSGD LL   AV +L+  LLP  S+ITPNL EA ALL      + +EM E  R LL  
Sbjct: 119 IAKSGDRLLEEEAVESLKKNLLPLASVITPNLMEAGALLG-REISSLEEMKEAARELLEF 177

Query: 169 GCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
           GC   ++KGGHL  E   D L  ++        R+ T   HGTGCT SAALA L  +   
Sbjct: 178 GCQWAIVKGGHLKGEP-VDVLANKDSLYLLRGQRVDTNCNHGTGCTFSAALATLMGQGLA 236

Query: 229 WADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
                + AK+++   L       +G G+G  HHF A
Sbjct: 237 VPAAAKRAKAYVEYCLEHG--FAIGEGVGIPHHFAA 270


>UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KLG7_9FIRM
          Length = 268

 Score =  305 bits (783), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 116/266 (43%), Positives = 160/266 (60%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   LTIAG+D SGGAG+QADLKT  A G YG S ITAL AQNT+GV+ V    P+F+
Sbjct: 1   MKK--VLTIAGSDSSGGAGVQADLKTMLANGVYGMSAITALTAQNTQGVRMVQEATPEFL 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AA+LD+VF D+R D  K+GM+A   ++  +A++L+ Y+ ++VV+D VM+A SG  LL   
Sbjct: 59  AAELDAVFEDIRPDAVKVGMVASPALIHVIADKLKAYKAEHVVVDPVMVATSGAKLLVDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L   L P   +ITPN+PE + L  A     E    +  + L A     VL KGGH 
Sbjct: 119 AIEVLVQELFPLAEVITPNIPELSVLTGA-EIADEFAFEQAAKKLAAEAEVNVLAKGGHF 177

Query: 181 DDEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D+ S   +    EGEQ +   R+   NTHGTGCTLS+A+AA   +  +  +++  AKS+
Sbjct: 178 ADDASDLLVLAGGEGEQWYRGTRVANPNTHGTGCTLSSAIAANLAKGFDLDESIGRAKSY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           L  AL     +++G G GPV H    
Sbjct: 238 LFGALLA--KMDLGRGNGPVDHGWNL 261


>UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Meiothermus silvanus DSM 9946 RepID=C1XR49_9DEIN
          Length = 278

 Score =  305 bits (783), Expect = 9e-82,   Method: Composition-based stats.
 Identities = 115/257 (44%), Positives = 156/257 (60%), Gaps = 4/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALT+AG+DPSGGAG+QADLKTF   G YG  V+T L  QNT GV+ V  +EP  VA QL+
Sbjct: 18  ALTVAGSDPSGGAGLQADLKTFHRFGVYGMGVVTVLTVQNTLGVREVVPLEPALVARQLE 77

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +V  D      K G L +  IV ++A  L +     +V+D V++AKSGD LL   A+  L
Sbjct: 78  AVLHDPGAHAIKTGALGDAAIVHSIAPLLAQ-AALPLVVDPVLVAKSGDSLLGGEALEAL 136

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +S LLP  +L+TPNL EA ALL  P  R   +  E  R L  +G  AVL+KGGHL  +++
Sbjct: 137 KSCLLPIAALLTPNLLEAQALLGQP-IRDLADAREAARLLACLGPRAVLLKGGHLAGKEA 195

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D L+       F   +I + +THGTGCTLSAA+ AL  +     + V  AK +++ A+A
Sbjct: 196 TDVLWDGHALHLFPEWKIPSVHTHGTGCTLSAAITALLAKGIPLHEAVARAKRFVTRAIA 255

Query: 246 QADTLEVGHGIGPVHHF 262
            A    +G GIGP++H+
Sbjct: 256 TAP--GIGRGIGPLNHW 270


>UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinibacter turnerae
           T7901 RepID=C5BTK8_TERTT
          Length = 274

 Score =  305 bits (782), Expect = 9e-82,   Method: Composition-based stats.
 Identities = 114/265 (43%), Positives = 162/265 (61%), Gaps = 2/265 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L IAG+DP GGAG+QAD+KT +ALG Y C+V TAL AQN+RGV +V+ + P+ + 
Sbjct: 4   QIPVVLAIAGSDPLGGAGLQADIKTAAALGGYCCTVTTALTAQNSRGVSAVWPVAPEQLR 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ  +V  D+     K+GML    ++  +A  L+      VVLD V+ A +G  LLS ++
Sbjct: 64  AQFSAVTEDITPGAIKVGMLGNAALIAELANLLRTQPNVPVVLDPVLAATAGGDLLSNAS 123

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              L ++LLP+V+L+TPNL EA+ LL+ P A  E +ML Q ++L  MG  AVL+KGGHL 
Sbjct: 124 GE-LVAQLLPRVTLLTPNLHEASRLLNCPPALDESDMLVQAKALREMGPRAVLIKGGHLA 182

Query: 182 DEQSPDWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             ++ D L +     QRF +PR+  +NTHGTGCTL+ A+A            V  AK ++
Sbjct: 183 SSRAIDILLSETNTVQRFASPRLAARNTHGTGCTLATAIATGLAAGHALPVAVACAKRFI 242

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
             A+A AD+L +    GP+ HF A 
Sbjct: 243 QQAIAHADSLNLVDENGPLQHFFAV 267


>UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular organisms
           RepID=A1RUE5_PYRIL
          Length = 450

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 96/260 (36%), Positives = 143/260 (55%), Gaps = 3/260 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    ++P  V
Sbjct: 1   MSWKVAMTIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLQPPLV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+ +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  
Sbjct: 61  RAQILAVWDDMGIDAGKTGMLGTREIIEEVAATVSKLGF-PLVVDPVMIAKSGAPLISED 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV TL+ RLLP   ++TPN  EA  L         +            G   V++KGGHL
Sbjct: 120 AVDTLKKRLLPVAKVVTPNRHEAEKLTGIKITSVAEARRAAEVIHREFGTEVVVVKGGHL 179

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D  ++ D ++          PR+ ++ THGTGC+ SAA+AA   +     + ++ AK ++
Sbjct: 180 DAPEAVDVVYIGGTFHELATPRLDSRATHGTGCSYSAAIAAGLAKGLPPLEAIKTAKRFI 239

Query: 241 SSALAQADTLEVGHGIGPVH 260
             A+     +  G G  PV+
Sbjct: 240 YMAIRYG--VARGKGHWPVN 257


>UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasmataceae
           RepID=Q3YSR2_EHRCJ
          Length = 269

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 92/264 (34%), Positives = 148/264 (56%), Gaps = 7/264 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +   LTIAG+D  GGAGIQAD+KT SALG Y  S IT++ AQNT  V +VY +  + +  
Sbjct: 7   KGKVLTIAGSDSCGGAGIQADIKTISALGCYAASCITSVTAQNTSQVYNVYNMPQNIIKQ 66

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++V SD+ ID  KIGML  ++ + AVA+ L       +V+D VM++ S   L+  SA+
Sbjct: 67  QIEAVLSDIDIDAIKIGMLPSSEAIIAVAQSL---PHIPIVVDPVMISTSNFRLMDNSAI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
                 ++ + ++ITPN+ EA  L        + +M++  + + ++G   VL+KGGH++ 
Sbjct: 124 FDFIKHIIYRATIITPNITEAEVLAQTKII-NQDDMIKASQQIKSLGAKYVLIKGGHINQ 182

Query: 183 EQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           E   + L T + +   F   RI     HGTGCTLS+A+A+   +  +  ++V  A  ++ 
Sbjct: 183 ETINNILLTEDNQILNFPHQRIFDGELHGTGCTLSSAIASFISQKISVQESVNLAIQYIL 242

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
             +      ++G G  PV H +  
Sbjct: 243 KTIKTVP--QIGKGNNPVFHNYNV 264


>UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q6C731_YARLI
          Length = 513

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 101/282 (35%), Positives = 149/282 (52%), Gaps = 24/282 (8%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD-FVAA 62
            + LTIAG+D SGGAGI+ADLKT +  G YG + IT L AQNT GV+ ++ IE   F+ A
Sbjct: 7   PSVLTIAGSDSSGGAGIEADLKTITVHGCYGMTTITGLTAQNTTGVEKIHPIEDQGFITA 66

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSPSA 121
            LD+VFSDV +D  K GML+  + +  V   L+++      V+D V+ + SG  L     
Sbjct: 67  CLDAVFSDVGVDVVKTGMLSSQETITTVTNYLKKHHANKASVIDPVLCSTSGSTLFPAEY 126

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPH------ARTEQEMLEQGRSLLAMGCGAVLM 175
           V+     L    +++TPN+PEA  L            +T Q+M +   S+   G   VL+
Sbjct: 127 VSVYLE-LFGLATIVTPNIPEAVELASVLEKKKFETPKTVQDMKDLAVSIHKTGAKWVLI 185

Query: 176 KGGHL-------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL              D+   D L+  +       P I TK+THGTGCTL++A+A+ 
Sbjct: 186 KGGHLSFTKDKEPAKENDTDKVVIDVLYDGKDFTELVMPYITTKSTHGTGCTLASAIASN 245

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
             +  +    V E   ++ +A+ +A    +G G GPV+H + 
Sbjct: 246 LAKGKDIPQAVLEGTQYIQNAIFEAH--PIGKGHGPVNHTYN 285


>UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptococcus agalactiae
           RepID=Q3D6X9_STRAG
          Length = 265

 Score =  304 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 112/258 (43%), Positives = 150/258 (58%), Gaps = 5/258 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAGTDPSGGAGI ADLKTF A   YG +V+T++VAQNT GV+ V  IE   +  QL
Sbjct: 6   PVLTIAGTDPSGGAGIMADLKTFQARRTYGMAVVTSVVAQNTCGVRGVQHIETAIIDQQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
             V+ D++    K GMLAE + +  VA  L++Y  Q  VLD VM+A SG  L+   AV  
Sbjct: 66  ACVYDDIKPKAVKTGMLAERETISLVASYLKKYP-QPYVLDPVMVATSGHRLIDSDAVEA 124

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMG-CGAVLMKGGHLDDE 183
           L+  LLP  ++ITPNLPEA  L+       E  +++ G  +        VL+KGGHLD  
Sbjct: 125 LKEDLLPLATIITPNLPEAEVLVGY-DLSDEVSIIKAGYDIQKQYSVRNVLIKGGHLDGL 183

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
                   +EG    +  RI T +THGTGCT +A +AA   +  +  + V  AKS+++SA
Sbjct: 184 AKDYLFLEKEGLITLSNQRINTIHTHGTGCTFAAVVAAELAKGQSILNAVSTAKSFITSA 243

Query: 244 LAQADTLEVGHGIGPVHH 261
           +  A  L +G   GPV+H
Sbjct: 244 IETAPELGLG--NGPVNH 259


>UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WHJ3_BACSK
          Length = 275

 Score =  304 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 108/261 (41%), Positives = 161/261 (61%), Gaps = 4/261 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAGTDP+GGAGIQADLKTF  L  YG SVIT+LVAQNT GV++++ +  +F+  Q 
Sbjct: 6   RALTIAGTDPTGGAGIQADLKTFQELEVYGMSVITSLVAQNTTGVRAIHHVPLEFIDQQF 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D+     K GM+A  +++E + ++L  ++    V D VM+AK+GDPLL     A 
Sbjct: 66  QAVVDDIYPSAIKTGMIALPEMMELLQQQLNSHKNVPYVCDPVMMAKNGDPLLEKHVRAK 125

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           LR  L+P  +++TPN+ EA  L+D      +       R +  +G  +V++KGG L  + 
Sbjct: 126 LRETLVPLATIVTPNIAEAEDLIDMQIDDIDDMEKAAIRIVKELGAQSVVVKGGSLTGD- 184

Query: 185 SPDWLFTRE-GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           + D  ++RE G  +  APR  TK+THGTGCT SAA+ A   +     D VQ+AK++ + A
Sbjct: 185 AVDVFYSRETGLFKLDAPRTDTKHTHGTGCTFSAAICAQLAKGIALLDAVQKAKAFTADA 244

Query: 244 LAQADTLEVGHGIGPVHHFHA 264
           +    +L++G+G GP +H+  
Sbjct: 245 ITW--SLQIGNGYGPTNHWGH 263


>UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobacterium
           RepID=Q7P2L0_FUSNV
          Length = 290

 Score =  303 bits (777), Expect = 4e-81,   Method: Composition-based stats.
 Identities = 91/273 (33%), Positives = 152/273 (55%), Gaps = 12/273 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK  N L+IAG+D S GAGIQADLKTF A G YG +VIT+L AQN + V+ +  +  + +
Sbjct: 14  MK--NVLSIAGSDCSAGAGIQADLKTFVANGVYGMTVITSLTAQNPQKVKMLEDVSIEML 71

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++++F  + +   KIGML   +  E + + L +Y+ +N+VLD VM+A SG+ L+   
Sbjct: 72  EKQIEAIFDVMEVSAVKIGMLNSKENGETIYDELLKYKARNIVLDPVMIATSGNSLIREE 131

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-------DAPHARTEQEMLEQGRSLLAMGCGAV 173
               L + L     LITPNL E   ++       +  +  + ++M   G+ +       V
Sbjct: 132 TKKFLVNELFKIADLITPNLDETKEIVKIILNNENIENIDSIEKMKNYGKVIADFTKKWV 191

Query: 174 LMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
           L+KGGHL    + D L  ++        +I + NTHGTGC+LS+A+A+   +  +  D+V
Sbjct: 192 LIKGGHL-SNSAVDILMNKDEIYILEGEKISSNNTHGTGCSLSSAIASNLAKDYSMLDSV 250

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++AK+++  ++    +++ G   G V+     +
Sbjct: 251 KKAKNFVLYSIKN--SIDFGEIAGTVNQMGEIY 281


>UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillales
           RepID=C6D361_PAESJ
          Length = 275

 Score =  303 bits (777), Expect = 4e-81,   Method: Composition-based stats.
 Identities = 105/243 (43%), Positives = 147/243 (60%), Gaps = 3/243 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF  LGAYG S +TA+ AQNT GVQ V+ +  + V AQ+ SV SD+ +D  K G
Sbjct: 26  IQADLKTFQELGAYGMSALTAITAQNTLGVQGVFPLAKEAVKAQIHSVGSDIGVDALKTG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VAE +  +  + VV+D VM+AK G  LL   AV  L  +LLP   +ITPN
Sbjct: 86  MLFSAEIIEEVAEAIAFFGWKKVVVDPVMIAKGGASLLQVEAVRALSRKLLPLTMIITPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L      R + + LE  + L ++G   VL+KGGH     + D L+   G    +
Sbjct: 146 IPEAEHLTGMA-IRNKNDKLEAAKKLSSLGARYVLIKGGHEAGADAVDLLYDGSGYSELS 204

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             RI+T+ THGTGCT SAAL A   +  +  + V++AK+++ +A+   D + VG G GP 
Sbjct: 205 GKRIVTERTHGTGCTYSAALTAGLAQGLDIEEAVRQAKAYIQAAIE--DGIIVGSGHGPT 262

Query: 260 HHF 262
           +H+
Sbjct: 263 NHW 265


>UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rhodopirellula
           baltica RepID=Q7UNH4_RHOBA
          Length = 275

 Score =  303 bits (776), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 107/256 (41%), Positives = 151/256 (58%), Gaps = 6/256 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+DPSGGAG+QADLKTF + G YGCSV+T L AQNT GVQ +  +  +FV AQ
Sbjct: 19  PVALTIAGSDPSGGAGMQADLKTFHSFGVYGCSVMTLLTAQNTMGVQGIQMVPAEFVRAQ 78

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             SV SD+ +   K G L   +++E VA+ L       +V+D VM++K G P++  +A+ 
Sbjct: 79  WTSVSSDLPLAAIKTGALGNAELIETVADCLHSL-ACPLVVDPVMISKHGHPIIDENAID 137

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L +R+ P   L+TPN  EA  L+     R E ++      LLAMG  AVL+K      E
Sbjct: 138 VLINRVFPLADLVTPNAFEAERLVG-QSIRNEDDLASVADKLLAMGPRAVLIKA--CVGE 194

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +S D L   +G Q   +PRI +  THG+GC LSAA+ A   +  +  + V+ A++++  A
Sbjct: 195 RSVDCLADADGAQLLRSPRIESNRTHGSGCVLSAAITAGLAKGQDLIEAVRTARNFVHDA 254

Query: 244 LAQADTLEVGHGIGPV 259
           +  A  L  G GI P+
Sbjct: 255 IRNAPKL--GQGISPL 268


>UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebacterium
           RepID=C5VF19_9CORY
          Length = 730

 Score =  302 bits (775), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 122/272 (44%), Positives = 157/272 (57%), Gaps = 8/272 (2%)

Query: 1   MKRI---NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           M+R      L+IAGTDP+GGAG QADLK+ +A G YG + ITALVAQNT GV+S++    
Sbjct: 223 MRRPSVPRVLSIAGTDPTGGAGAQADLKSIAAAGGYGMNAITALVAQNTHGVRSIHTPPL 282

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
            F+  QLD+V SDV ID  KIGML   DIV  V + L  + +  VVLD VM+A SGD LL
Sbjct: 283 SFLREQLDAVVSDVTIDAVKIGMLGSADIVACVRQWLAEHPMPLVVLDPVMVATSGDRLL 342

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPH-ARTEQEMLEQGRSLLAMGCGAVLMK 176
            P A   +       V ++TPN+PE A LL AP  ART +E L Q           V+ K
Sbjct: 343 DPDAEQAVIE-FAHHVDIVTPNVPELAVLLSAPEPARTFEEALSQAAEFAQKSNTIVIAK 401

Query: 177 GGHLDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           GGHLD + + + +   +G     T PRI T NTHGTGC+LS+ALA          + ++ 
Sbjct: 402 GGHLDGKLANNAVVYPDGRITTITTPRIDTTNTHGTGCSLSSALATRLAAGDTITEAIEW 461

Query: 236 AKSWLSSALAQADTLEVGH--GIGPVHHFHAW 265
              WL+ ++     LEVG   G GP+ HFH  
Sbjct: 462 VSYWLADSIRAGAALEVGTPGGHGPIDHFHQV 493


>UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WH83_BACSK
          Length = 272

 Score =  302 bits (774), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 105/261 (40%), Positives = 153/261 (58%), Gaps = 2/261 (0%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L++AG+D SGGAGIQAD+KT   LG Y  + ITA+ AQNT GVQS   ++   V
Sbjct: 1   MPIPTVLSVAGSDSSGGAGIQADIKTCQELGVYAATAITAITAQNTTGVQSWQGLDASLV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++V SD+ +   K GML   DIV  VAE    Y++ N+V+D VM + SG  LLS  
Sbjct: 61  RDQIEAVLSDIGVHVIKTGMLVNADIVTTVAELANTYRVANIVVDPVMASTSGTALLSAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L  +LLP  ++ TPNLPE A LL+ P  +T  EM      L  MG   V++KGGHL
Sbjct: 121 GQQVLVQKLLPLATVFTPNLPETAMLLNKPECKTVAEMKAAAVQLHKMGPKLVILKGGHL 180

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              ++ D  +  +      A R+  K+THGTGCT ++A+AA   +     +  ++AK+++
Sbjct: 181 RQGEAIDLCYDGQAFFELKAKRLDRKHTHGTGCTFASAIAAELAKGAKPIEAAKKAKAYV 240

Query: 241 SSALAQADTLEVGHGIGPVHH 261
           ++A+++   + +G GIGP  H
Sbjct: 241 TAAISEG--IPLGAGIGPTDH 259


>UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanocaldococcus infernus
           ME RepID=C5U665_9EURY
          Length = 442

 Score =  301 bits (772), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 88/257 (34%), Positives = 140/257 (54%), Gaps = 8/257 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+D   GAGI+ADLKTF + G YG   ITA+ AQNT  ++ +  ++   V  Q
Sbjct: 8   KKALTIAGSDSGSGAGIEADLKTFCSFGVYGLVAITAITAQNTYEIREIRELDAKIVREQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V  D  +D  K GML   +I++ V + ++ YQ   +V+D VML+K+   LL   A+ 
Sbjct: 68  IIAVAEDFGVDAAKTGMLYSGEIIKEVRKVVKDYQF-PLVVDPVMLSKTNTLLLKEDAIE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   L    +LITPN+ EA  L  +       + +E  ++L       +L+KGGHL  E
Sbjct: 127 KL-ENLFKISTLITPNINEAEFL-SSKKITNLDDAIEVAKTLFEKYKTNILIKGGHLKGE 184

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L+  E  + F + R+ +  THGTGC+ SAA+ A   +     + +++AK ++  +
Sbjct: 185 -AIDILYNGE-LKLFKSQRV-SGCTHGTGCSFSAAITACLAKGEELEEAIKKAKDFIIKS 241

Query: 244 LAQADTLEVGHGIGPVH 260
           +    +  +G    PV+
Sbjct: 242 IRN--SYRIGKKYCPVN 256


>UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamine-phosphate
           pyrophosphorylase (Tmp pyrophosphorylase) (Tmp-ppase)
           (Thiamine-phosphate synthase); phosphomethylpyrimidine
           kinase (Hmp-phosphate kinase) (Hmp-p kinase)] n=16
           Tax=Bacteria RepID=B0RGG3_CLAMS
          Length = 752

 Score =  301 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 132/269 (49%), Positives = 166/269 (61%), Gaps = 7/269 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A G YG +V+TALVAQNT GV+ ++     F+ AQ
Sbjct: 262 PRVLSIAGTDPTGGAGIQADLKSIAANGGYGMAVVTALVAQNTTGVREIHVPPVAFLRAQ 321

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD+V  DV ID  KIGML    +V+ VA  L   +   VVLD VM+A+SGD LL   A  
Sbjct: 322 LDAVSDDVAIDAVKIGMLGSAAVVDEVAAWLGAVRPPVVVLDPVMVAQSGDALLDADATE 381

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            LR RLLP   ++TPNLPE AALL    A   +  L QGR+L       V++KGGHL  +
Sbjct: 382 ALR-RLLPLADVVTPNLPELAALLGEREADGWEAALAQGRTLATRHGVRVVVKGGHLRVD 440

Query: 184 QSPDWLFTRE------GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
             PD L T               PRI T +THGTGC+LS+ALA L+PR  +W   + EAK
Sbjct: 441 DCPDALVTPGAGGAGPTAHVVDGPRIATTSTHGTGCSLSSALATLQPRRDDWRAALTEAK 500

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +WL+ +LA A+ L VG G GP+ H  A W
Sbjct: 501 AWLTGSLAHAEDLGVGSGAGPLDHLRALW 529


>UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=B4RNJ4_NEIG2
          Length = 288

 Score =  300 bits (770), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 104/246 (42%), Positives = 146/246 (59%), Gaps = 6/246 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF   G +G  VITA+ AQNT GV +V+ +  + + AQ+ ++  D  I   KIG
Sbjct: 42  IQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKIG 101

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA++L+       VLD VM+AK G PLL  SAVA L   LLP   ++TPN
Sbjct: 102 MLGTAEIIECVADKLKHCSFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDILTPN 161

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE---QSPDWLFTREGEQ 196
           LPEA AL    H    ++     + LL  G   V++KGGHL+     +  DWLFT+    
Sbjct: 162 LPEAEALTGV-HIENRKDAERAAKILLDYGVKNVIIKGGHLNGSTSGRCTDWLFTQNETL 220

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
              +PR  T +THGTGCT SA + A   +  +    VQ AK+++++A+  ++ LE+G G 
Sbjct: 221 ELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVQTAKAYITAAI--SNPLEIGAGH 278

Query: 257 GPVHHF 262
           GPV+H+
Sbjct: 279 GPVNHW 284


>UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31JD4_THICR
          Length = 281

 Score =  299 bits (766), Expect = 7e-80,   Method: Composition-based stats.
 Identities = 109/267 (40%), Positives = 161/267 (60%), Gaps = 8/267 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+DP GGAGIQADLK+  ALG Y  + ITAL AQN++GV  V     D +  Q
Sbjct: 6   PTVLSIAGSDPYGGAGIQADLKSIHALGGYALTCITALTAQNSQGVAHVVATSSDILNHQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD++  D+++D  KIGMLA  +++  VA+++ +Y ++N+VLDTV+++ SG PLL  SA+ 
Sbjct: 66  LDTLLQDIKVDAVKIGMLANAELINVVADKITQYSLKNIVLDTVLISSSGHPLLEESAIE 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDD 182
            L+ RL P+ ++ITPNLPE   LL        QEM     + L +G  AV+ KGGH L+ 
Sbjct: 126 CLKKRLFPKATIITPNLPEINHLLGTHFHGIAQEMDAIKEAFLKLGAQAVVAKGGHGLET 185

Query: 183 EQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           + + D L         F++PRI T +THGTGC+ S+A+A    +  +    VQ+AK  + 
Sbjct: 186 DLATDVLLQPNHPPMPFSSPRIQTSHTHGTGCSFSSAIATFLAQGNDLTSAVQQAKQQMH 245

Query: 242 SALAQADTLE------VGHGIGPVHHF 262
               Q+++L+      + H   P+HH 
Sbjct: 246 LWFGQSESLQFDYQSNLTHRKEPLHHL 272


>UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria (class)
           RepID=B8DSX8_BIFA0
          Length = 516

 Score =  298 bits (764), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 107/263 (40%), Positives = 146/263 (55%), Gaps = 3/263 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LTIA TD SGGAGI ADLKT  A   +G  V+  + AQNT GVQ++  ++P  V 
Sbjct: 255 KLPAVLTIATTDSSGGAGIPADLKTMLANDVFGECVVAGITAQNTTGVQAIAAVDPSIVG 314

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+DSVF D+R    KIG++   + V+ VA +L+ +Q  N+V+D VM+A SG  L +   
Sbjct: 315 AQIDSVFDDIRPTAVKIGVIVGVESVKTVARKLRDHQATNIVVDPVMVATSGSSLAADDT 374

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +A   S L P  ++ITPN+PEA  L   P    + +M      L       VL+KGGH  
Sbjct: 375 IAEEISSLFPIATVITPNIPEAQVLAQMP-IGNQADMETAAVQLAKDYGTCVLVKGGHGV 433

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            +      F       F   RI   NTHGTGCTLS+A+A+   +  +  D V++AK++LS
Sbjct: 434 KDADDVLAFPTGAVTWFEGERIANDNTHGTGCTLSSAIASYLAQGEDLEDAVRDAKAYLS 493

Query: 242 SALAQADTLEVGHGIGPVHHFHA 264
            AL     L +G G GP+ H  A
Sbjct: 494 GALRA--NLNLGKGHGPMDHAWA 514


>UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia denitrificans DSM
           20603 RepID=C7R3Y2_JONDD
          Length = 518

 Score =  297 bits (761), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 113/267 (42%), Positives = 152/267 (56%), Gaps = 8/267 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  LTIAGTDP+GGAG+QAD+KT +A G Y  SV+TA+VAQNT GV+    +    VA Q
Sbjct: 8   IRVLTIAGTDPTGGAGVQADIKTITACGGYALSVVTAVVAQNTVGVRCFESVSSSLVADQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V SD      K+GML +  +   V E   R+    +V+D VM+A SGD L++  A  
Sbjct: 68  LAAVASDTAPAAVKVGMLGDPAVSREVCEF-ARHLTVPLVVDPVMVATSGDELVTGVARE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP  +LITPN+PE A L    HA +++E+  Q R +      AVL KGGH   +
Sbjct: 127 ALWE-LLPLATLITPNIPELAVLSGMAHAVSDEELEHQARLVAHKFGVAVLAKGGHRVGD 185

Query: 184 QSPDWLFTREGE------QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            + D L    G           A R+ T +THGTGC+LS+A+A L  R  +  + V+ AK
Sbjct: 186 TASDVLIGAPGPGGQCEAVWVHAQRVNTTSTHGTGCSLSSAIATLLGRGYDLPEAVRRAK 245

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHA 264
            WL+ A+   D + VG G GP+ H  A
Sbjct: 246 VWLTQAIRAGDRMAVGTGHGPLDHMWA 272


>UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicutes
           RepID=D1BR35_VEIPT
          Length = 277

 Score =  297 bits (761), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 103/263 (39%), Positives = 155/263 (58%), Gaps = 6/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   ALTIAGTDPSGGAGI ADLK+F +   YG +V+T++VAQNT GV  V  +  + +
Sbjct: 1   MKLHTALTIAGTDPSGGAGIMADLKSFQSRNVYGMAVVTSVVAQNTTGVHHVEHLSLESI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL  V+SD+     K GM+A  ++++ +   + +      V+D VM+A SGD L+S  
Sbjct: 61  EKQLHDVYSDITPQAVKTGMIALPEMMDLIYPYVSK--NIPYVMDPVMIATSGDRLVSDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV  L+S+L+P  ++ITPN  EA  L D              R L  +G   V++KGGH+
Sbjct: 119 AVDFLKSKLIPVATVITPNRSEAEVLADMSITCESDITTAANRILRELGPQVVIIKGGHI 178

Query: 181 DDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             + + D+ FT++G+   +T+P+  T +THGTGCT SA + A   +  +  D +  AK++
Sbjct: 179 -GDDATDYAFTKDGDMHTWTSPKYDTVHTHGTGCTFSAVITAELAKGRDVMDAIGIAKNY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           ++ A+     L  G+G GPV+H 
Sbjct: 238 IALAIKHNPAL--GNGCGPVNHM 258


>UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovum sp. NBC37-1
           RepID=A6Q7N2_SULNB
          Length = 270

 Score =  297 bits (760), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 105/250 (42%), Positives = 155/250 (62%), Gaps = 1/250 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG DP GGAG+  D+KT  ALG Y  S +TA+ AQN+ GV+SV+   P+ + AQ
Sbjct: 7   PTVLTIAGFDPYGGAGVVMDVKTIHALGGYALSSVTAVTAQNSTGVKSVHNTAPEILRAQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L+ +  D+ +D  KIGMLA+ ++V+++ E +Q+Y ++N+VLDTV+++ SG  L+   AV 
Sbjct: 67  LEVLLDDISVDAVKIGMLADKEVVQSIVEIIQKYDLKNIVLDTVLVSSSGRQLIREDAVE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            ++  L P V LITPN+PE   L    ++  E E  E  ++   +G  AVL+KGGH + E
Sbjct: 127 VMKKELFPLVDLITPNIPEVNTLQHHTYSGKESETQEVAQAFFDLGVNAVLLKGGHSEAE 186

Query: 184 QSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           ++ D L  R+G    F   RI T +THGTGC LS+A+A    +     ++V  AK +LS 
Sbjct: 187 EAIDHLVQRDGTMESFAHRRIDTTHTHGTGCLLSSAVATGLAKGLEMNESVSGAKDFLSR 246

Query: 243 ALAQADTLEV 252
            L  AD L++
Sbjct: 247 KLEHADELDL 256


>UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=18
           Tax=Actinomycetales RepID=THIED_CORGL
          Length = 763

 Score =  296 bits (758), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 115/261 (44%), Positives = 156/261 (59%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A G YG  V+T+LVAQNT GV +++     F+  Q
Sbjct: 242 PRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTSLVAQNTHGVNTIHTPPLTFLEEQ 301

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L++VFSDV +D  K+GML   D V+ VA  L  ++   VVLD VM+A SGD LL  SA  
Sbjct: 302 LEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEE 361

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           +LR RL   V ++TPN+PE A L D+  A T  E + Q +         V++KGGHL   
Sbjct: 362 SLR-RLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGA 420

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            + + +   +G   +    R+ T N+HGTGC+LSA+LA       +    ++ +  WL+ 
Sbjct: 421 LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATKIAAGESVEKALEWSTRWLNE 480

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           AL  AD L VG G GPV H H
Sbjct: 481 ALRHADHLAVGTGNGPVDHGH 501


>UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=Q2S369_SALRD
          Length = 290

 Score =  296 bits (758), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 111/264 (42%), Positives = 158/264 (59%), Gaps = 4/264 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +  ALTIAG+D  GGAGIQADLK   A G +G S + A+ AQNT  V   + + P  VA 
Sbjct: 4   KPVALTIAGSDSGGGAGIQADLKAMEANGVFGASALAAVTAQNTEEVSRAHDLPPSLVAT 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V  D+ +   K GML+   I+E VA+R+  + ++  V+D VM++K+G  LL   A+
Sbjct: 64  QIDAVVGDMDVKAAKTGMLSAPPIIETVADRVATHDLRPFVVDPVMISKTGFKLLQDEAI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
            TL + LLP  +L+TPN+ EA  L D     T  ++   G +LL  G  AVL+KGGHL  
Sbjct: 124 DTLVNDLLPLATLVTPNVHEAEHLTDV-EIDTPDDLRAAGAALLEYGPDAVLVKGGHLSG 182

Query: 183 -EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            + + D L   E  +RF APRI T++THGTGCT ++A+AA   +  +    V  AK +++
Sbjct: 183 ADDAVDVLVDGETGRRFQAPRIDTEHTHGTGCTYASAIAAHLAKGHDLGAAVDRAKRYVT 242

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
            A+  A  L +GHG GP +HF   
Sbjct: 243 GAIRHA--LPLGHGRGPTNHFFHL 264


>UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_BACSU
          Length = 271

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 108/263 (41%), Positives = 150/263 (57%), Gaps = 4/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQAD+KTF  L  +G S ITA+ AQNT GV  V+ +  + +
Sbjct: 1   MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  D+R D  K GML   D++E VA ++  Y    V++D VM+AK G  LL   
Sbjct: 61  RQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           +VATL+  L+P+   ITPN+PEA  L       +  +  +    L+ MG   V++KGGH 
Sbjct: 121 SVATLKELLIPRSYAITPNVPEAETLTGMT-ISSLDDRKKAAEQLVKMGAQHVIIKGGHQ 179

Query: 181 -DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +D    D LF      + T P I TK+THGTGCT +AAL A   +  +     + A ++
Sbjct: 180 PEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANF 239

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           +  A+    TL +G G GP +HF
Sbjct: 240 VREAVEN--TLGIGSGHGPTNHF 260


>UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B7D2_THEAS
          Length = 271

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 113/263 (42%), Positives = 146/263 (55%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R  A+TIAG+D  GGAGIQADLKTF  L  +G S +TA+ AQN+ GV  V  +    V
Sbjct: 1   MYRGVAMTIAGSDSGGGAGIQADLKTFMGLNVFGVSAVTAVTAQNSMGVYHVENLSVRSV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+  + SD  +   KIGML+  +I+EAVAE L  Y    VVLD VM+++SG  L+   
Sbjct: 61  REQIRCLLSDFPVRAVKIGMLSTGEIMEAVAEELSSYP-GPVVLDPVMVSQSGHSLMDSG 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPH--ARTEQEMLEQGRSLLAMGCGAVLMKGG 178
           A   +R RLLP  SL+TPNLPEA  LL  P     T+ +ML+    LL  GC  VL+KGG
Sbjct: 120 AERAMRERLLPLASLVTPNLPEAERLLGLPPGSIATKGDMLDAANRLLEAGCRGVLLKGG 179

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           HL  +   D L     E  F   RI   N HGTGCTLS+A+AA      +    V   + 
Sbjct: 180 HLPGDDIFDVLICGAEEVLFEDRRIPGGNDHGTGCTLSSAIAAELAAGEDLKTAVTRGRE 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           ++   +     L  G G G ++H
Sbjct: 240 FVRRGMETGVRL--GRGHGCLYH 260


>UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Flavobacteriaceae
           RepID=Q1VWC4_9FLAO
          Length = 269

 Score =  294 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 104/249 (41%), Positives = 156/249 (62%), Gaps = 3/249 (1%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K+  A GAY  ++ITA+ AQNT GV ++  + P  +A QL +V  D+  D  KI
Sbjct: 20  GIQADIKSAGACGAYSATIITAITAQNTLGVNAIEGVSPQMIANQLTAVMDDIGADALKI 79

Query: 79  GMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           GML   +++E VA+ LQ Y+ +++VLD VM+A SGDPLL   A+  L  +++PQ  +ITP
Sbjct: 80  GMLHSKEVIEEVAKHLQHYKAKHIVLDPVMVATSGDPLLQEDAIQALMHQIIPQAEVITP 139

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQ-- 196
           N+PE   LL     +   E  +  R+L      +VL+K GHL  ++S D LF  + +Q  
Sbjct: 140 NVPEMELLLGET-IKNTTEFSDYARALAEKFKVSVLLKAGHLKGDKSVDILFNVKTKQIT 198

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
           + ++PRI TKNTHGTGC+LS+ALA+   +  +  D  Q+AK+++  A+      ++G G 
Sbjct: 199 KLSSPRITTKNTHGTGCSLSSALASYLAQGFSLEDASQKAKTFIYQAIKAGGDYKLGKGS 258

Query: 257 GPVHHFHAW 265
           GP+HHF+  
Sbjct: 259 GPIHHFYKL 267


>UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leotiomyceta
           RepID=C0NXA7_AJECG
          Length = 488

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 98/272 (36%), Positives = 156/272 (57%), Gaps = 18/272 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ +   FV
Sbjct: 1   MKLKRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVVPVGFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++   DV  D  K+GMLA  +  E VA+ L  +++  VVLD VM++ SG  LL   
Sbjct: 61  RKQINAGLEDVGADVVKLGMLASAETAEMVADTLWHHKVSKVVLDPVMVSTSGSELLPAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQ-----EMLEQGRSLLAMGCGAVLM 175
           AV  ++++LLP  +++TPN+PEA  LL    A T+      + ++  + +  +G   VL+
Sbjct: 121 AVNIVQTKLLPLTTIVTPNIPEAILLLQGSGAATKDPENLEDAIQIAKQIHTLGPKYVLL 180

Query: 176 KGGHLDDEQSPDWLFTREGEQRFTAPRIMT-KNTHGTGCTLSAALAALRPRHTNWADTVQ 234
           KGGH+           R   +   + RI   KNTHGTGC+L++A+AA   +  +    V+
Sbjct: 181 KGGHMP----------RTCSRSLASSRISCLKNTHGTGCSLASAIAANLAQGMDVVRAVR 230

Query: 235 EAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            A  ++ + +    ++++G G GP++HFH+ +
Sbjct: 231 AACRFVEAGIRT--SVDMGKGNGPINHFHSVY 260


>UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TP80_9BACT
          Length = 271

 Score =  293 bits (750), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 97/242 (40%), Positives = 145/242 (59%), Gaps = 3/242 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+AL  +G S +TA+ AQN+ GVQ+++ I P+ +  Q+ SV SD  I   K G
Sbjct: 22  IQADLKTFAALRVFGTSALTAVTAQNSLGVQAIHDIPPEIIYEQMKSVLSDFSIGAVKTG 81

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +TD +  V   ++ + +  +V+D VM+A+SGD L+   AV+ ++  LLP  +L+TPN
Sbjct: 82  MLGKTDAIGVVCRAVRDFSVHKLVVDPVMIAQSGDSLIQDDAVSAIKEELLPLATLVTPN 141

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L         + M+    ++  MG  AVL+KGGHL+ E+  D L++     +F 
Sbjct: 142 VPEAERLSGL-EVSDVEGMIAAASAIAGMGPQAVLVKGGHLEGEKVVDVLWSSGKPIKFE 200

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +PRI T+N HGTGCTLSAA+A+           V+  +++L  AL +    + G G GP 
Sbjct: 201 SPRIDTENNHGTGCTLSAAIASELAAGCELDLAVERGRAYLMMALERG--FKPGKGYGPT 258

Query: 260 HH 261
            H
Sbjct: 259 GH 260


>UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria RepID=A1WTB6_HALHL
          Length = 271

 Score =  293 bits (750), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 113/247 (45%), Positives = 148/247 (59%), Gaps = 3/247 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLK   ALG Y C+ ITAL AQNT+GVQ V+ + P F+ AQ+ SV +D+  D  K G
Sbjct: 24  IQADLKAVMALGGYCCTAITALTAQNTQGVQDVHTVPPGFIRAQIRSVLTDIGADCVKTG 83

Query: 80  MLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML +T +++AVA  L        +V+D VM+A+SGD LL+ +A   L   LLP+ +L+TP
Sbjct: 84  MLHDTAVIDAVAAELDALAPGVPLVVDPVMVAQSGDRLLAEAAAERLGDVLLPRATLLTP 143

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRF 198
           NLPEA  LL      TE  + E  R+L   G  AVL+KGGH   ++  D L T EGE  F
Sbjct: 144 NLPEAEVLLGRSVPATESGLQEAARALRGYGAEAVLVKGGHAPGDEVIDCLATPEGEVCF 203

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            + RI T + HGTGCTL++A+AA   R    +D V  A+ +L  AL  A  L  G G GP
Sbjct: 204 RSRRIETNSNHGTGCTLASAIAAGVARGLPLSDAVPHARDYLQEALRTARGL--GGGAGP 261

Query: 259 VHHFHAW 265
           V+H    
Sbjct: 262 VNHAFNV 268


>UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Erythrobacter RepID=Q2N848_ERYLH
          Length = 269

 Score =  292 bits (749), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 114/265 (43%), Positives = 148/265 (55%), Gaps = 7/265 (2%)

Query: 1   MKR--INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD 58
           M R     L IAG+D SGGAGIQAD+KT + LG Y  + ITA+ AQN+ GVQ +  ++  
Sbjct: 1   MSRQPPRILAIAGSDSSGGAGIQADIKTITMLGGYAMTAITAVTAQNSVGVQGITPLDGA 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLL 117
           FV  Q+ S   D+ +D  KIGML   DI+ AVA  L+    Q  +VLD VM+A SG PL+
Sbjct: 61  FVGQQIASAIDDIGVDAIKIGMLQNEDIILAVANALEEIDPQVPIVLDPVMVATSGAPLV 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
              AVAT+R RL  +  L+TPNLPE   LL     RT + + E    L       VL KG
Sbjct: 121 VQDAVATMRERLFTKARLLTPNLPELE-LLAGKQLRTTELVREAAEDLARHYGCDVLAKG 179

Query: 178 GHLDDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GH  DE+  D L    G   +F   RI T++THGTGCTLS+A+A L          V+ A
Sbjct: 180 GHTADERIIDVLVPVGGRMAQFDDARIDTRHTHGTGCTLSSAIATLLGHGQPMEHAVRLA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHH 261
           + ++  A+  A     G G GP+ H
Sbjct: 240 RRFVREAIENAP--GFGDGAGPLGH 262


>UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_BACSU
          Length = 271

 Score =  291 bits (746), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 96/264 (36%), Positives = 146/264 (55%), Gaps = 5/264 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQ--NTRGVQSVYRIEPD 58
           M    ALTIAG+D SGGAGIQADLKTF     YG + +T +VA   N      V+ I+ D
Sbjct: 1   MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAMDPNNSWNHQVFPIDTD 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
            + AQL ++   + +D  K GML   DI+E  A+ ++  Q++NVV+D VM+ K  + +L 
Sbjct: 61  TIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLKNVVIDPVMVCKGANEVLY 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK-G 177
           P     LR +L P  ++ITPNL EA+ L      +T  +M+E  + + A+G   V++  G
Sbjct: 121 PEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDMIEAAKKIHALGAQYVVITGG 180

Query: 178 GHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           G L  E++ D L+  E  +   +  I T  THG GCT SAA+ A   +     + +  AK
Sbjct: 181 GKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTFSAAVTAELAKGAEVKEAIYAAK 240

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
            ++++A+ ++  L     +GP  H
Sbjct: 241 EFITAAIKESFPLN--QYVGPTKH 262


>UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase n=2
           Tax=Bacteria RepID=Q2LST1_SYNAS
          Length = 293

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 101/247 (40%), Positives = 146/247 (59%), Gaps = 4/247 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT + LG +G SVITAL AQNT GVQ ++ +   F+  Q D+V +D+ +D  K G
Sbjct: 22  IQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPISFIEQQFDAVATDIGVDAAKTG 81

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    +V AVA ++++++I+ +V+D V+ AK G  L+   A+ TL S LLP   ++TPN
Sbjct: 82  MLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIEDEAMETLVSDLLPLAFVVTPN 141

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  + +     +  +M E  R +   G   V++KGGHL  E + D L+       F 
Sbjct: 142 VPEAEVMAEMT-ISSVADMKEAARRIRRFGVPNVIVKGGHLPGE-ALDILYDGSTYHEFA 199

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           A RI TK+THGTGCT SAALA          D+V+EAKS+++  +  A    +G G GP 
Sbjct: 200 AERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYITEVIRYA--WRIGGGHGPT 257

Query: 260 HHFHAWW 266
           +H    +
Sbjct: 258 NHAAPLF 264


>UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobium/Pelodictyon group
           RepID=Q3ASE2_CHLCH
          Length = 275

 Score =  290 bits (742), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 120/272 (44%), Positives = 163/272 (59%), Gaps = 7/272 (2%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MKR    LTIAG+D SGGAGIQADLKTF+AL  YG SVITA+ AQNT+GV  V+ +E   
Sbjct: 1   MKRYTTVLTIAGSDGSGGAGIQADLKTFAALRCYGVSVITAITAQNTQGVSGVFPVENHC 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI--QNVVLDTVMLAKSGDPLL 117
           + AQ +++  D+  D  KIGML     +  +A  L+        ++LDTV+ + SG  LL
Sbjct: 61  LQAQFEALQKDITFDAIKIGMLGSASTITTLAALLRALPTPRPPIILDTVLASSSGMALL 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHA-RTEQEMLEQGRSLLAMGCGAVLMK 176
            PSA+A + S+L P  +LITPN+PE A L       +T QE+    + L A G  +VL+K
Sbjct: 121 PPSAIACMVSKLFPLATLITPNIPECALLAGKSAVPQTAQEIEAVAKELQAQGAASVLIK 180

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH    +  D L  +E  Q F+AP I T NTHGTGCTLS+A+AA   +     + V +A
Sbjct: 181 GGHGKSNECHDCLLWQERCQWFSAPMIATHNTHGTGCTLSSAIAAFMAKGYPLDNAVLQA 240

Query: 237 KSWLSSALAQADTLEVG---HGIGPVHHFHAW 265
           K++L+SAL      ++G   +G GP+ H    
Sbjct: 241 KNYLNSALQAGAAYQLGMSANGHGPLFHLWEL 272


>UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobacterium
           RepID=D1NSS6_9BIFI
          Length = 521

 Score =  288 bits (739), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 106/266 (39%), Positives = 150/266 (56%), Gaps = 6/266 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             AL+IA TD SGGAG+  D+KT  A G +   VI A+ AQNT+GV  +  + P  +  Q
Sbjct: 257 PAALSIASTDSSGGAGVPVDIKTMMANGVFAECVICAITAQNTKGVTHLEELSPQAIVKQ 316

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V+ D+     KIGM+   + + AVA+ LQ  +  N+V+D VM+A SG  L++  A+A
Sbjct: 317 IDAVYDDIAPAAVKIGMVPSIEGINAVADGLQANKATNIVVDPVMVATSGAKLINDDAIA 376

Query: 124 TLRSRLLPQVSLITPNLPEAAALLD----APHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           TL SRL P  +LITPNLPE   LL+    +   + E  M + G ++      +VL+KGGH
Sbjct: 377 TLTSRLFPMATLITPNLPETRVLLETIGSSIDPQDEDGMEQAGLAIAQHFGCSVLVKGGH 436

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              + +   +      Q F   RI   NTHGTGCTLS+A+AA   +     D +  AK +
Sbjct: 437 GLADANDVLVNADGTTQWFRGERINNPNTHGTGCTLSSAIAANLAKGQTLVDAIANAKRY 496

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           ++ AL Q   LE+G G GP  H   W
Sbjct: 497 ITGALRQM--LELGTGSGPFDHAWMW 520


>UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobaculum
           RepID=A4WJ58_PYRAR
          Length = 449

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 98/260 (37%), Positives = 150/260 (57%), Gaps = 4/260 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R+ A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    + P  V
Sbjct: 1   MWRV-AITIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLAPSLV 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+ +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  
Sbjct: 60  RSQIMAVWDDMGIDAGKTGMLGTREIIEEVASTVSKLGF-PLVVDPVMVAKSGAPLISDD 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV  LR RLLP   ++TPN PEA  L     A  +             G   V++KGGHL
Sbjct: 119 AVDVLRRRLLPVAKVVTPNRPEAERLTGMKIASEKDAERAAEYINKEYGTEVVVVKGGHL 178

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +  ++ D ++ +    +F+ PR+ ++ THGTGC  SAA+AA   +  +  + ++ AK ++
Sbjct: 179 EGAEAVDVVYYKGSFHKFSTPRLESRATHGTGCAYSAAIAAALAKGLDPLEAIKTAKRFI 238

Query: 241 SSALAQADTLEVGHGIGPVH 260
            +A+     +  G G  PV+
Sbjct: 239 YTAIKYG--VSRGKGHWPVN 256


>UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanospirillum hungatei
           JF-1 RepID=Q2FLY4_METHJ
          Length = 257

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 91/246 (36%), Positives = 142/246 (57%), Gaps = 4/246 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+DPSGGAGIQ DLKTF+  G +G +VITAL AQN   V   + ++P+ V  Q
Sbjct: 6   PAALTIAGSDPSGGAGIQMDLKTFAKTGVWGMAVITALTAQNAAQVTGSWPMDPEMVREQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V  D+     K GMLA T+I++AV E + +     +V+D VM++ SG  LL+  A+ 
Sbjct: 66  IIAVLEDLTPGAIKTGMLANTEIIKAVEETVPK--DVPLVIDPVMISTSGYRLLNDDAIC 123

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +  RL+P   LITPN+PEA  +       ++++++  G  ++ +G   VL+KGGH   +
Sbjct: 124 DICERLIPLAHLITPNIPEAEIISQMK-IASDEDVILAGSKIMDLGAKQVLIKGGHGKGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+L  +EG   F   R+   + HG+GC LSAA+     +  +     ++AK  ++  
Sbjct: 183 DAIDYLIMKEGNISFRHTRL-PYDVHGSGCCLSAAITGYIAQGFDDISCCKKAKDLVTFG 241

Query: 244 LAQADT 249
           +  A  
Sbjct: 242 IRHAYE 247


>UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular organisms
           RepID=Q478V3_DECAR
          Length = 291

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 83/249 (33%), Positives = 134/249 (53%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            L  A +DPS GAGIQADL T ++LG +  + +TA+  Q+T GVQSV+ +  + +  Q  
Sbjct: 14  VLVFAASDPSSGAGIQADLLTLASLGCHPLTALTAVTVQDTVGVQSVHPLAAELLEQQAR 73

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D+ +   KIG+L   + V AVAE +  Y    ++LD V+ +  GD L S   ++ +
Sbjct: 74  TILEDMPVVAFKIGVLGSVENVLAVAEIVSDYPEIPLILDPVLASGRGDDLSSEEIISAI 133

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLPQ +L+TPN PEA  L ++    +E  +    + L+ MG   VL+ G H +  Q 
Sbjct: 134 REMLLPQTTLLTPNAPEARRLAESDEDESEPSIDICAQRLIEMGAQYVLITGTHENTPQV 193

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            + L+  +G  R      +  + HG+GCTL++A+A       +  D V++A+ +   AL 
Sbjct: 194 INTLYGPDGVVRRDEWERLPGSYHGSGCTLASAIAGCIAGGASIEDAVRDAQDYTWQALK 253

Query: 246 QADTLEVGH 254
                 +G 
Sbjct: 254 NGFRAGMGQ 262


>UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprothermobacter
           proteolyticus DSM 5265 RepID=B5Y6H9_COPPD
          Length = 262

 Score =  286 bits (732), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 93/248 (37%), Positives = 139/248 (56%), Gaps = 4/248 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+ADL TF  L  +G   ITA+ AQN+RGV  V+ I PD V AQ+D+V  D  +   K G
Sbjct: 14  IEADLATFLHLHVFGTVAITAVTAQNSRGVHGVFDIPPDGVRAQIDAVLKDFSVGAVKTG 73

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  + +  VA+ L  Y  + +V+D VM+A+SGD L+   AV  L  +LLP   ++TPN
Sbjct: 74  MLSREETISEVAKALSEYNCKKLVVDPVMVAQSGDSLIFGDAVKALEEKLLPLAFIVTPN 133

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L      ++ ++M +  +++  +G  +VL+KGGHL+++Q  D  +       FT
Sbjct: 134 IPEAQILTGIT-IKSSEDMKKAAKAISKLGPQSVLVKGGHLEEKQLVDLFYYEGEFYTFT 192

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             +I T + HGTGCTLSAA+ A    +T   + V+ A  +    +      + G G G V
Sbjct: 193 HEKIDTLDHHGTGCTLSAAITAELAANTETVEAVKRAIDYTRLGIEH--RFKGGKGYGCV 250

Query: 260 HH-FHAWW 266
            H F   W
Sbjct: 251 GHIFDIDW 258


>UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI00005103C2
          Length = 288

 Score =  286 bits (732), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 133/276 (48%), Positives = 159/276 (57%), Gaps = 18/276 (6%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             AL+IAGTDPSGGAGI ADLKTF+A G  G + ITALVAQNT GV  VY I+ DFV+ Q
Sbjct: 6   PIALSIAGTDPSGGAGIHADLKTFTARGVLGTTAITALVAQNTHGVSRVYGIDDDFVSDQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LDSV +D+ +D TK GML    +VE V  R  + Q+    +D VM+A SG  L    AV 
Sbjct: 66  LDSVLNDMPVDATKSGMLGSRSLVELVVARAAQGQLGFYTVDPVMVATSGHRLHEVDAVT 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLD--APHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
            +R  LLP   LITPNLPEAA L+    P A+  QEML Q R L+  G  AVL+KGGH  
Sbjct: 126 AVRDHLLPVSDLITPNLPEAALLIGDDEPVAKNPQEMLVQARQLVHRGPRAVLLKGGHAI 185

Query: 182 DEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRP-----------RHTNW 229
           +    D L T EG    FT PR+ T NTHGTGCTLSAA+ A                   
Sbjct: 186 EGDVADVLVTAEGTVTEFTHPRVETPNTHGTGCTLSAAITAEVAVLKRARAVDDVSSDLL 245

Query: 230 ADTVQEAKSWLSSALAQADTLEV---GHG-IGPVHH 261
            + V  A ++L+ AL  A   +V     G  GPV H
Sbjct: 246 HEAVDNALNYLARALKSAANWQVSFDPKGAHGPVDH 281


>UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovibrionales
           RepID=C6BTQ6_DESAD
          Length = 453

 Score =  285 bits (731), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 108/264 (40%), Positives = 151/264 (57%), Gaps = 7/264 (2%)

Query: 1   MK-RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     LTIAG+D  GGAGIQADLK  S  G YG S ITAL AQNT GV  +  + P+F
Sbjct: 1   MKPLPCVLTIAGSDSGGGAGIQADLKAISMAGCYGASAITALTAQNTTGVTGIEAVSPEF 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           VA Q+++V SD+++   K GML    I+ AV E L+      +V+D V +A SG  LL  
Sbjct: 61  VALQIETVCSDIKVSAAKTGMLFSAPIIRAVGESLKDKDF-PLVIDPVCVATSGAKLLKD 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            AV  ++  + P   L+TPN+PEA  L      ++ +++ +    LL MG  AVL+KGGH
Sbjct: 120 DAVEAMKE-IFPLAELLTPNVPEAE-LFTGMEIKSREDVFKAIEILLEMGPKAVLVKGGH 177

Query: 180 LDDEQSPDWL-FTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            D   + DWL    +        R+ TKN+HGTGCTLSA +A+   +  +    V++A+ 
Sbjct: 178 FDSVAATDWLGIKGQQPIPLMQQRVKTKNSHGTGCTLSATIASGLAKGYDMVTAVRKAQE 237

Query: 239 WLSSALAQADTLEVGHGIGPVHHF 262
           +L+ AL      ++G G GP +H 
Sbjct: 238 YLNLALRAG--FDLGEGSGPPNHL 259


>UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholderiaceae
           RepID=A4SX91_POLSQ
          Length = 293

 Score =  285 bits (730), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 102/257 (39%), Positives = 144/257 (56%), Gaps = 11/257 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLK  +ALG YG SVITA+ AQNT GV  +  ++ D V AQ+D+V  D+  D  KIG
Sbjct: 28  LQADLKVITALGGYGMSVITAITAQNTLGVTRIQDVDLDVVEAQIDAVLMDIGADIVKIG 87

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA  +IV  VA+ L+R+ ++ ++LD V+ A SG  L        + + L P  SL+TPN
Sbjct: 88  MLASPEIVRTVAKALRRHGVKRIILDPVLRATSGASLGGDDTAQAMIAELFPIASLVTPN 147

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD--EQSPDWLFTREGE-- 195
           L EA+ LL         +     + LL MG  AVL+KGGHLD    Q  D+L  R  E  
Sbjct: 148 LEEASLLLG-REISGPNDFKLAAQELLDMGPQAVLIKGGHLDSTHTQITDFLMWRSVEDE 206

Query: 196 ------QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADT 249
                 + F   R+ T NTHGTGCTL++A+A       +   +V +A +++ + L     
Sbjct: 207 LEVILTKEFKHYRVNTINTHGTGCTLASAIATYLADGHDLLHSVAKAIAYVEAGLEAGRF 266

Query: 250 LEVGHGIGPVHHFHAWW 266
           L +G G GP+ H H ++
Sbjct: 267 LSIGEGPGPLWHMHDFY 283


>UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobacillales
           RepID=C7TG65_LACRL
          Length = 283

 Score =  285 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 99/247 (40%), Positives = 148/247 (59%), Gaps = 4/247 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLKTF A   +G S++ AL AQNT GVQ+   I  DF+ AQ  S+ +D  I   K G
Sbjct: 23  MQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPGDFIDAQFQSLAADFAIKACKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA+++ V AV   L++     +++D VM+AK G  LL+P AVAT++  LLP   ++TPN
Sbjct: 83  MLADSEHVNAVVRNLKQVNFGPLIVDPVMVAKGGATLLAPEAVATIKQELLPLADVVTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREG-EQRF 198
           LPEA  ++  P  + E +M+   +++  +G   V++KGGH  D Q+ D++   +G     
Sbjct: 143 LPEAEIIVGHP-IKREADMIAAAQTIQELGVKNVIIKGGHRQDAQASDFILLADGSSFWV 201

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            +PRI T NTHGTG T SA +AA   +  +    +  AK++L  A++Q   + VGHG GP
Sbjct: 202 RSPRIATGNTHGTGDTFSACIAAELAKGESLKKAIITAKAFLEGAISQG--IFVGHGHGP 259

Query: 259 VHHFHAW 265
            +H+   
Sbjct: 260 TNHWATL 266


>UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=uncultured archaeon
           RepID=D1JA17_9ARCH
          Length = 438

 Score =  285 bits (729), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 104/255 (40%), Positives = 149/255 (58%), Gaps = 8/255 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR   +TI G+D SGGAGIQAD+KTFSAL  +G SV+TA+ AQN+ GVQ++  +    V
Sbjct: 1   MKR--VMTIGGSDCSGGAGIQADIKTFSALAVHGTSVLTAITAQNSDGVQAIQEVPVKIV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV SD+ +D  K GML   +I+   A +L+RY +   VLD VM A +G  LL  +
Sbjct: 59  EQQLESVMSDIAVDYAKTGMLYSAEIIAVAATQLKRYGV-PFVLDPVMKAGAGGILLDDN 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL   L+P  +++TPN+PEA+ +      R  ++       +  MG  AV++KGGHL
Sbjct: 118 ALNTLIELLIPICAVVTPNVPEASIISGL-EIRNIEDAKLAALKINDMGASAVIIKGGHL 176

Query: 181 DDE----QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           + E    ++ D ++  E E+  T+     K  HG GCT SAALAA   + TN  D    A
Sbjct: 177 EHEIAAGKATDLIYDGEFERISTSMIKQGKIVHGAGCTFSAALAAELAKGTNLHDAATSA 236

Query: 237 KSWLSSALAQADTLE 251
           K ++  A+   + L 
Sbjct: 237 KKFVYDAILCGEKLP 251


>UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2V558_NAEGR
          Length = 538

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 95/256 (37%), Positives = 142/256 (55%), Gaps = 13/256 (5%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADL TF A   +G S ITAL AQNT GVQ V+ +  +F+A Q+DSV SD+ I + K 
Sbjct: 280 GIQADLNTFHAHHLFGTSAITALTAQNTLGVQGVFPVSAEFLAKQIDSVMSDINIVSVKT 339

Query: 79  GMLAETDIVEAVAERLQRY----QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           GML  ++++  V E+L+ Y        VV+D VM++ SG  LL   AV  L     P  +
Sbjct: 340 GMLYSSELIRVVIEKLKHYRELNPNIKVVVDPVMVSTSGHNLLKDEAVDALVREFFPMAT 399

Query: 135 LITPNLPEAAALLDAPH----ARTEQEMLEQGRSLLA-MGCGAVLMKGGHL-DDEQSPDW 188
           LITPN+PEA  +L+         T +   +  +++    G   VL+KGGHL + E + D 
Sbjct: 400 LITPNIPEAERILELTDSPFKITTVELSKKAAKTISETFGIRNVLVKGGHLINSEYAVDI 459

Query: 189 LFTREGEQR--FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           L+  E ++     A  I + NTHGTGC+L+AA+A+     +   D V+ +K ++ +A+ +
Sbjct: 460 LYESEADRFVSLHANFIQSNNTHGTGCSLAAAIASNLALGSTLEDAVRRSKLYVLNAIVR 519

Query: 247 ADTLEVGH-GIGPVHH 261
                    G G ++H
Sbjct: 520 GFNPSQNQTGHGTLNH 535


>UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes RepID=B2AXQ5_PODAN
          Length = 532

 Score =  284 bits (727), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 98/289 (33%), Positives = 160/289 (55%), Gaps = 26/289 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT GV  ++ +  +F+
Sbjct: 1   MPPGRILVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTLGVHGIHHVPAEFL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  +     TK GM+A    +EAVAE ++ Y+++ VV+D VM+A +G PLL  +
Sbjct: 61  RKQIDAVGLNCTDCKTK-GMMASAGTIEAVAEVIREYKLKTVVVDPVMVATTGSPLLPNT 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           +++ LR +L+P  +++TPNLPEA  LL              ++    R++ ++G   VL+
Sbjct: 120 SLSLLREKLVPLATVLTPNLPEARLLLADAGFGHLPVEKVSDLEGIARAVGSLGPKWVLI 179

Query: 176 KGGHLD-------------DEQSPDWLFTREGE-----QRFTAPRIMTKNTHGTGCTLSA 217
           KGGH                E+  D L+ R+ +     ++   P   +K+THGTGC+L++
Sbjct: 180 KGGHCPFNGEGMIAAEEGKREKVVDVLWGRDEKGGEVLRQVETPYWESKHTHGTGCSLAS 239

Query: 218 ALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           A+A    +  +    V+ A  ++ + +  A  L  G G GP++HFH+ +
Sbjct: 240 AIACNLAKRMDMPQAVEAACRYVEAGIKTAPGL--GKGNGPLNHFHSTY 286


>UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermoplasmatales
           RepID=Q97BE3_THEVO
          Length = 266

 Score =  283 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 96/264 (36%), Positives = 149/264 (56%), Gaps = 6/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQADLKTF++L  +G SVITA+ AQN+  V  +  + P+FV
Sbjct: 1   MPIPKALTIAGSDSGGGAGIQADLKTFNSLSVFGMSVITAVTAQNSYEVSGILPVPPEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  D+++D  K GML  ++I++ V   ++ Y I+ V++D VM++KS   LL   
Sbjct: 61  KLQIDTVAKDIKVDGAKTGMLFSSEIIKVVTGSIKDYSIKPVIVDPVMVSKSNARLLRED 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSL-LAMGCGAVLMKGGH 179
           A+ +L   LLP+ +++TPN+PEA  L       T ++M      +   +G   VL+KGGH
Sbjct: 121 AIESLIKYLLPESTIVTPNIPEAEILASM-SISTIEDMKAAAEKIGTEIGLK-VLVKGGH 178

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +     D  +      +F   R  TKNTHGTG TLS+A+ +   +     + +   K +
Sbjct: 179 FNGPP-IDIYYDGSNILKFEGTRYETKNTHGTGDTLSSAILSFLIKGYREQEAIALGKEY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +  ++    +   G G G + H+ 
Sbjct: 238 VEGSIRN--SFPTGSGFGSLCHWW 259


>UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobiaceae
           RepID=B3QNM3_CHLP8
          Length = 276

 Score =  282 bits (723), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 103/245 (42%), Positives = 139/245 (56%), Gaps = 3/245 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT +A   YG SVITA+ AQ+T GV  V+ I   F+A Q +++ SD+RID  KIG
Sbjct: 24  IQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQFETIVSDIRIDAIKIG 83

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML      E +A  +       +VLDTV+ + SG  L S +  A ++ RL P VSLITPN
Sbjct: 84  MLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAAMK-RLFPLVSLITPN 142

Query: 140 LPEAAALLD--APHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR 197
           LPEA  L    AP +  ++E+ +    L   G  +VL+KGGH + +   D L   E    
Sbjct: 143 LPEATMLTGRNAPPSGGKEEIEQIALELQMQGAPSVLVKGGHWEGKVCHDCLLHEERFYW 202

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F+ P+I T NTHGTGCTLS+A+AA        ++ V     +   AL       +GHG G
Sbjct: 203 FSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVARGIDYTRKALQAGAGWRLGHGHG 262

Query: 258 PVHHF 262
           P++HF
Sbjct: 263 PLYHF 267


>UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7MH55_BRAFD
          Length = 599

 Score =  282 bits (722), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 103/254 (40%), Positives = 158/254 (62%), Gaps = 2/254 (0%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           +IAGTDP+GGAG  ADLK+ +A G YG +V+TA+VAQNTRGV+ ++    + +AAQL +V
Sbjct: 3   SIAGTDPTGGAGTAADLKSITAAGGYGMAVVTAVVAQNTRGVRDIHVPPAEVLAAQLTAV 62

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
             DV ++  K GML   ++++ VA  +  +  + +V+D VM+A SGD LL P A   +  
Sbjct: 63  SDDVELEAVKTGMLGTVEVIDTVAAWVAAHPPRVLVVDPVMVASSGDRLLEPEAEQAMI- 121

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPD 187
           R   + +++TPN+ E A L  +P A TE+E L Q  +  A    +V++K GHL+D +  +
Sbjct: 122 RFCARATVVTPNIDELAVLTGSPRASTEEEALAQATAWTARTGASVIVKTGHLEDREVTN 181

Query: 188 WLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
                +G ++R  + R+ T +THGTGC+L+AALA       + A  ++ A +WL  A+A 
Sbjct: 182 TWVAPDGAQRRARSTRVDTTSTHGTGCSLAAALATRLGAGHSPAAALEWATAWLHEAIAH 241

Query: 247 ADTLEVGHGIGPVH 260
             +L+VG G GPV 
Sbjct: 242 GASLQVGAGHGPVD 255


>UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0W4_9BACT
          Length = 274

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 109/268 (40%), Positives = 147/268 (54%), Gaps = 9/268 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D S GAG+QADLKT SALG YG + IT +VA+    V ++  IEP  VA Q
Sbjct: 3   PVGLTIAGSDNSAGAGVQADLKTMSALGVYGVTAITCVVAEVPGKVSAIQAIEPRIVAEQ 62

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-----QIQNVVLDTVMLAKSGDPLLS 118
           +  +F    I   K GML   +I+E V + L+       Q   +V+D VM+A SGDPLL 
Sbjct: 63  IRLLFEAFPIGALKTGMLYSCEIIETVCDTLRGCREPMPQPPPIVVDPVMVATSGDPLLQ 122

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+A  R RL P  +LITPNL E   LLD     +  EM   G+ L+A    A L+KGG
Sbjct: 123 RDAIALYRERLFPMATLITPNLDEVRTLLD-REVTSVAEMRTAGQELVATYGRAFLIKGG 181

Query: 179 HLDDEQSPDWLFTRE-GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           HL    + D L   + G Q F+AP +   +THGTGCT +AA+ A   +  + ++   EAK
Sbjct: 182 HLRLNPAIDLLCAPDGGVQEFSAPFVPGVSTHGTGCTYAAAITAGLAKGLSLSEAASEAK 241

Query: 238 SWLSSALAQADTLEV--GHGIGPVHHFH 263
            +L++ +A         G     +HHF 
Sbjct: 242 QYLATTVAHFLRWPREDGRTTDALHHFW 269


>UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=9
           Tax=cellular organisms RepID=B8H441_CAUCN
          Length = 267

 Score =  281 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 103/246 (41%), Positives = 145/246 (58%), Gaps = 3/246 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT +ALG Y  + ITA+  QNT GV  V+ I  D +AAQ  +V  D+  D  K G
Sbjct: 23  IQADIKTITALGGYAATAITAVTVQNTLGVTGVHPIPLDVIAAQARAVLDDIGADAIKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +  +VE VA+ L        V+D VM+AK G PLL+ +A+  ++S ++P+  L+TPN
Sbjct: 83  MLGDAAVVEIVAQALDHAGGVPAVVDPVMVAKGGAPLLAEAAIGAVKSLMIPRAFLLTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
            PEAAAL       T +++   G +LLA+G  AVLMKGGH+  E+  D L T  GE  F 
Sbjct: 143 APEAAALTGL-VVETTEDLRRAGEALLALGARAVLMKGGHVAGERVVDVLMTPAGETTFE 201

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             RI T++THGTGCTL++A AA   +     + V +A +++  A+ +A     G G GP+
Sbjct: 202 GERIDTRHTHGTGCTLASACAAGLAKGLKLEEAVAQAWNYVHEAMLRAP--GFGAGHGPL 259

Query: 260 HHFHAW 265
            H    
Sbjct: 260 DHGWTL 265


>UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1INF7_ACIBL
          Length = 254

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 90/259 (34%), Positives = 133/259 (51%), Gaps = 7/259 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG DPS GAGI AD+KT +A   Y  + ITA+  Q T  V +V  +  + V   
Sbjct: 2   PIVLSIAGYDPSSGAGITADVKTAAAHECYAITCITAVTVQTTEKVFAVEPLRAEIVRDT 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L  +  D+     +IGML   ++ E VA+ L+  +++NVVLD V+ + SG  L+      
Sbjct: 62  LYELVRDMPPAAVRIGMLGSGEVAEVVADFLETTRLRNVVLDPVLRSTSGAALIDERGEQ 121

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R+RLL  V + TPN  EA  L +      E       R L   GC AV++ GG  + E
Sbjct: 122 VIRARLLKAVDVCTPNEAEARVLAEC-----EASPEGLARELHRKGCPAVVITGG--ERE 174

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            S D L   + ++   A +I ++ THGTGC  + A+A          + V EAK ++  A
Sbjct: 175 DSGDLLSFGDQQEWLRAEKIRSRATHGTGCAFATAIACNLALGRQLREAVVEAKFYVRRA 234

Query: 244 LAQADTLEVGHGIGPVHHF 262
           +       +GHG GP++HF
Sbjct: 235 ITLGSDEPLGHGRGPMNHF 253


>UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=Q1ASC3_RUBXD
          Length = 264

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 106/265 (40%), Positives = 144/265 (54%), Gaps = 7/265 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR   ++IA +D   GAGIQADLK F   G YG + + A+ AQNT GV+S++   P   
Sbjct: 1   MKR--VMSIATSDSGAGAGIQADLKAFLRCGVYGTTALVAITAQNTVGVRSIFPFPPRVA 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++V  D+  D  K GML   +I+ AVA  ++R  I N+V+D VM+A+SG  LL   
Sbjct: 59  VDQIEAVVEDIGADAAKTGMLFNAEIISAVAGAVRRLGIPNLVVDPVMVAESGAKLLKDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AVAT +  L P  ++ITPN+ EA ALL A     E  + E    L + G GAV++ GGH 
Sbjct: 119 AVATYKQELFPLAAVITPNINEAFALLGAEV--DEGRVREAAAELRSFGSGAVIITGGHT 176

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D L+  E       P   ++NTHG GCT SAALA+   R     +  + A+   
Sbjct: 177 AS--GADLLYDGERFLEIEGPTYGSENTHGAGCTHSAALASFLARGLGLEEAARRAREVA 234

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           S A+      E+G G GPVH   A 
Sbjct: 235 SEAVRYGLG-EIGSGAGPVHALGAV 258


>UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=48
           Tax=Lactobacillales RepID=Q040Q3_LACGA
          Length = 278

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 100/266 (37%), Positives = 145/266 (54%), Gaps = 6/266 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           + I ALTIAG D  G AG+ ADL  F A G YG  ++TA VA N++G+ +   +  DF+ 
Sbjct: 10  EHIEALTIAGHDSDGSAGMPADLHAFYARGVYGMGLLTAAVAGNSQGIFAQQLMPLDFIQ 69

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q D +  D +I   K GMLA  DI+  VA+ L+ YQ+QN+VLD V++ K G  LL+  A
Sbjct: 70  KQFDVLNDDFKIKAVKTGMLANKDIINVVAKNLEHYQMQNIVLDPVIITKHGATLLADDA 129

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
                 +L+P  ++ITPN  EA  L      + E E+ +  + L  MG   VL+KG H +
Sbjct: 130 YQAFLKKLVPLATIITPNFFEAQKLTGL-ELKNESEIKQGAKMLQKMGAKNVLIKGSHHN 188

Query: 182 DEQ--SPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           D+Q    D+L   +G ++    P   T   +GTG TLSA +AA   +  +    V+ AK 
Sbjct: 189 DKQTEVKDYLLLEDGSDEWLIKPYFKTDRVNGTGDTLSAVIAAELAKGNDVKTAVKIAKD 248

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
           +   AL+    + VG   GP++H  A
Sbjct: 249 FTYEALSH--PINVGAKYGPINHLAA 272


>UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L3K0_MAGSM
          Length = 260

 Score =  280 bits (716), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 99/258 (38%), Positives = 142/258 (55%), Gaps = 4/258 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+DP  GAG+QADLKT +ALG YG +V+TA+  QN+  V  V+ +E   VAAQ
Sbjct: 3   PCVLTIAGSDPCAGAGLQADLKTITALGGYGATVVTAITVQNSVKVSQVHPVEGSLVAAQ 62

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V SD+ I   K+GML    +VEAV   L  Y    VV DTV+   +G  LL+   VA
Sbjct: 63  MRAVLSDLPIKAIKLGMLGNRGVVEAVLSVLDHYPEIPVVADTVLRGSAGGALLADEDVA 122

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
                LLP+  LITPNL EA  L          ++      L+ +GCG V++ GGHL   
Sbjct: 123 HFVQHLLPRCHLITPNLDEAQRLTGLEGGVGVADLESLAYRLMGLGCGGVVLTGGHLVGN 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKN-THGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +  D L  + G +R+   +I +K   HGTGCTL++A+A    +  +  + V+E  +++  
Sbjct: 183 KVVDTLVCKGGIKRWIGEKIASKEGFHGTGCTLASAVALGVAKGLDDFEAVEEGIAYVRQ 242

Query: 243 ALAQADTLEVGH---GIG 257
            + ++  L  G    G G
Sbjct: 243 TIRRSIKLGSGQRFLGHG 260


>UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobacillus
           RepID=C6VJ68_LACPJ
          Length = 274

 Score =  279 bits (714), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 103/261 (39%), Positives = 154/261 (59%), Gaps = 5/261 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
               TIAGTD  GGAG+ ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q
Sbjct: 5   PQVATIAGTDSGGGAGVMADLKTMQARHVFGTAVVVAVTAQNTLGVQDFMAMPTKLIDEQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             S+ +D+ I   K GMLA+ + V AV E L+R+    + +D VM+AK G  LL+  A+ 
Sbjct: 65  FASLAADLDIRACKTGMLADAEHVHAVVENLKRFDFGPLTVDPVMIAKGGAALLAADAIK 124

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD- 182
           T+R  LLP  +++TPNLPEA  L       + Q M++ G SL  +G   V++KGGH D+ 
Sbjct: 125 TVRDELLPLATVVTPNLPEAEQLTG-QSITSNQAMVKAGHSLQGLGADNVIIKGGHGDNP 183

Query: 183 EQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           + + D++   +G     +APRI T  THGTG TLSA + A   +  + A  ++ AK++++
Sbjct: 184 DLANDFVLLADGTAFWLSAPRIDTVRTHGTGDTLSACITAELAKGRSMAAAIKTAKAYVA 243

Query: 242 SALAQADTLEVGHGIGPVHHF 262
             +   D ++VGHG GP++H+
Sbjct: 244 GTIQ--DGIQVGHGHGPLNHW 262


>UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochlorococcus marinus
           RepID=Q7V2V2_PROMP
          Length = 262

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 87/246 (35%), Positives = 147/246 (59%), Gaps = 5/246 (2%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           QADL+TF AL  +GCSVIT + AQN+  V+ V  ++ D + +Q+D++FSD  I + K GM
Sbjct: 21  QADLRTFMALKVHGCSVITCVTAQNSVQVKCVEPLKKDTLTSQIDTLFSDFDIKSLKTGM 80

Query: 81  LAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNL 140
           L    I+ A A +L+ + I  ++ D VM++++G  LL  SA+   +  LLP   L+TPN+
Sbjct: 81  LLNDSIINATALKLKSFSIPKII-DPVMVSRTGSKLLEDSAINAYKKLLLPIADLVTPNI 139

Query: 141 PEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFT-REGEQRFT 199
            EA  LL     + + ++ +  +S++ +G  AVL+KGG L D +  D+      G++ F 
Sbjct: 140 FEAN-LLSNLDIKNQVDIEQSAKSIIKLGAKAVLIKGGGLKDMKGRDFYLDVNGGKKWFI 198

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
              I T+NTH +GCTLSAA+   +    +  +++Q++K ++  +L    + ++G G GP+
Sbjct: 199 NKFINTQNTHCSGCTLSAAICGYQALGFDLIESIQKSKIFIERSLKN--SYQIGSGPGPL 256

Query: 260 HHFHAW 265
            H+ + 
Sbjct: 257 GHYQSL 262


>UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI00017450E5
          Length = 269

 Score =  276 bits (707), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 106/261 (40%), Positives = 144/261 (55%), Gaps = 4/261 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+D SGGAGIQADLKTF+ALG YG + IT++VA+    V S+  +EPD + AQ
Sbjct: 6   PVVLSIAGSDCSGGAGIQADLKTFTALGCYGMTAITSVVAETPAVVDSIQLLEPDIIGAQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ--NVVLDTVMLAKSGDPLLSPSA 121
           +  +   + +   K GML     +EAV E  Q        +V+D VM+A SG  LL   A
Sbjct: 66  IRVLAKGMPLAAAKTGMLGGRKQIEAVVEAWQPMAQAEVPLVVDPVMVATSGGRLLERDA 125

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
             TL   LLP   +ITPNL EAA LL A    +  EML   ++L  +   AVLMKGGHL 
Sbjct: 126 EETLIGHLLPLARVITPNLDEAAVLLGAA-ITSRGEMLSAAQTLAKIHGVAVLMKGGHLA 184

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            + +PD L      + +   RI   +THGTGCT SAA+AA         + V   K +++
Sbjct: 185 GDAAPDLLVDGTLVRWYEGERISGVHTHGTGCTYSAAIAAGLGSGLGLEEAVALGKKFVT 244

Query: 242 SALAQADTLE-VGHGIGPVHH 261
           +A+ Q    +  G  I  ++H
Sbjct: 245 AAIRQHFRWQHDGAEIDALNH 265


>UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharophagus degradans
           2-40 RepID=Q21NU7_SACD2
          Length = 282

 Score =  276 bits (706), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 115/265 (43%), Positives = 162/265 (61%), Gaps = 4/265 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L+IA +D  G AGIQAD+KT  AL AY  + ITA+ AQN+ GV +++ +  + +
Sbjct: 1   MTPTAILSIAASDSFGAAGIQADIKTAMALHAYCATAITAVTAQNSLGVAAIHPVPANIL 60

Query: 61  AAQLDSV---FSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPL 116
           +AQ  +    F   R+   KIGML   + + AV   +Q+      VV+DTV+ A SG  L
Sbjct: 61  SAQFTAAAQGFLPARLGAIKIGMLGHAEALPAVVSFVQQLAGAIPVVVDTVLNASSGAVL 120

Query: 117 LSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
           L PSAV   R  LLP  +LITPNL EAA LLDAP A +E +  EQ ++LL +GCGAVL+K
Sbjct: 121 LPPSAVRAYRESLLPLATLITPNLHEAALLLDAPLATSEAQQREQAQALLQLGCGAVLLK 180

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH +   + D+L T  GE RF++ +I T N+ GTGC+L+AA+A    +       V+ A
Sbjct: 181 GGHFEGNSASDYLVTPHGEARFSSSKIQTNNSRGTGCSLAAAIAVGIAQGQPLEQAVEAA 240

Query: 237 KSWLSSALAQADTLEVGHGIGPVHH 261
           K+++S+AL  A   ++  G GP+ H
Sbjct: 241 KNYISAALQGAVGWQLAQGSGPICH 265


>UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold_16 n=1
           Tax=Sordaria macrospora RepID=D1ZB20_SORMA
          Length = 536

 Score =  275 bits (705), Expect = 8e-73,   Method: Composition-based stats.
 Identities = 102/294 (34%), Positives = 158/294 (53%), Gaps = 34/294 (11%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT+GV  ++ +  DF+  Q
Sbjct: 12  PRVLVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTKGVYGIHEVPVDFLRKQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V  DV +D  K GMLA T  +EAVA+ +   +++ +V+D VM+A +G  LL  SA  
Sbjct: 72  IDAVVEDVGVDVVKTGMLASTSTIEAVAQAIHDNKLKTLVVDPVMIATTGAELLPNSASR 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
            LR +LLP  +++TPN+PEA  LL     D    ++  ++ E    +  +G   VL+KGG
Sbjct: 132 ALREKLLPLATILTPNVPEANTLLLEAGHDKHLVQSVADLEEIALKVQKLGSKWVLVKGG 191

Query: 179 HL-------------DDEQSPDWLF---------TREGEQRF-----TAPRIMTKNTHGT 211
           H              + E   + L            EGE++        P   ++NTHGT
Sbjct: 192 HSPFRRDGTEAKTEDEKEIVVNVLVGPAAEGTKRDVEGEEKLQVVKIEMPYQRSRNTHGT 251

Query: 212 GCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           GC+L++A+A+   +  +    V+    ++ +A+  A  L  G G GP++HFH+ 
Sbjct: 252 GCSLASAIASNLAKGMDMVSAVKAGIRYVDAAIRTAPGL--GQGNGPLNHFHSV 303


>UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kinase n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q449_9BACT
          Length = 276

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 100/257 (38%), Positives = 146/257 (56%), Gaps = 8/257 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D  GGAGIQAD+KT +ALG Y  + ITAL AQNT G+ +VY I   FVA Q+
Sbjct: 10  KALTIAGSDSIGGAGIQADMKTIAALGGYAATAITALTAQNTLGIHAVYEIPASFVARQI 69

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+V SD   D  K GML   DI+E VA RL+ Y +  VV+D VML+K+G  LL+  A+  
Sbjct: 70  DAVVSDTGADIVKTGMLYSKDIIETVASRLKHYALSPVVVDPVMLSKNGAALLAEDAIPA 129

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL---- 180
           L S+L P   ++TPN+PEAA +      +   +  +  + +  +G   VL+KGGH     
Sbjct: 130 LISQLFPLAFIVTPNIPEAAHISGIK-IQNITDAEKAAKYIHKLGPANVLIKGGHALHSS 188

Query: 181 ---DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
                    D L+T +         +  K+ HGTGC  ++A+AA   +    A+ V++AK
Sbjct: 189 DIKSSNTVIDILYTGKSFAYIEGEYLPAKHVHGTGCVYASAIAAYLAKGCGIAEAVRQAK 248

Query: 238 SWLSSALAQADTLEVGH 254
            ++   + ++ +   G+
Sbjct: 249 KFVVLCIKKSFSPGRGY 265


>UniRef50_C2CTG3 Multifunctional thiamine-phosphate
           pyrophosphorylase/synthase/phosphomethylpyrimidine
           kinase n=1 Tax=Gardnerella vaginalis ATCC 14019
           RepID=C2CTG3_GARVA
          Length = 565

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 112/269 (41%), Positives = 148/269 (55%), Gaps = 12/269 (4%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A   +   V T LVAQNT GV+ VY    DF+ AQ
Sbjct: 37  PRVLSIAGTDPTGGAGIQADLKSITASHGFAMCVTTNLVAQNTCGVREVYTPPTDFLQAQ 96

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L++VF DV ID  KIGML +   +  V + L+ + +  VVLD VM+A SGD LL  SA  
Sbjct: 97  LEAVFDDVTIDAVKIGMLGDKSYISLVQDWLKNHPVPVVVLDPVMVATSGDRLLEKSAED 156

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R    P   +ITPN+PE A L D   A   +E   Q     A     V++KGGHL  E
Sbjct: 157 AMRE-FAPLADVITPNIPELAVLCDKQPASNFEEAYAQASEWCAKNNTIVIVKGGHLTSE 215

Query: 184 QSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHT----------NWADT 232
            + + +   +G +     PR+ T  THGTGC+LS++LA                   AD 
Sbjct: 216 DAGNTVVFPDGHRVHVPCPRVDTTTTHGTGCSLSSSLATRIGLALREGKKLSDYSTVADA 275

Query: 233 VQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           +  +  WL+ A+A    L VG G GPV+H
Sbjct: 276 LAWSSRWLNEAIACGKDLHVGKGHGPVNH 304


>UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=O26711_METTH
          Length = 253

 Score =  275 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 100/259 (38%), Positives = 141/259 (54%), Gaps = 14/259 (5%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           AL+IAG DPSGGAGI AD+KTFSALG YG  VITAL AQN   V  +  + P FV  QLD
Sbjct: 3   ALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQLD 62

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            V  D+ +   K GML   +IVEAVAE+++ Y ++ V++D VM+A SG  L   + V  L
Sbjct: 63  LVMEDLPVVHAKTGMLYSAEIVEAVAEKVREYGLR-VIVDPVMVAASGGELSEGNFVRAL 121

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLP+  ++TPN+ EA  L D P   T  + +   R +  +    V++ GGHL     
Sbjct: 122 RRHLLPEALIVTPNVAEAERLSDIP-IGTVDDAIRAARVIGEL--CDVIITGGHLGGRSV 178

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
              L   + E       + ++NTHG+GC+ SAA AA   R  +  + ++ A  ++  A+ 
Sbjct: 179 I--LIDGDVEV-LEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIR 235

Query: 246 QADTLEVGHGIGPVHHFHA 264
                      G ++ F  
Sbjct: 236 HGH-------HGTLNQFWM 247


>UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FQ29_NANOT
          Length = 492

 Score =  275 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 97/284 (34%), Positives = 144/284 (50%), Gaps = 29/284 (10%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ I  +FV
Sbjct: 1   MGLKRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVIPTEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+ +   DV  D  KIGMLA  +    VAE L+ +++ ++ LD          LL P 
Sbjct: 61  RKQIRAGLEDVGADGVKIGMLASMETAVMVAEELKAHKVPSITLDP---------LLPPD 111

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           AV  +R  LLP  +++TPN+PEA  LL     D        + +   +++  +G   +L+
Sbjct: 112 AVKAVRENLLPITTVLTPNIPEAVLLLRDSGVDVKEPGNLDDAIALAKNIHQLGPKHILL 171

Query: 176 KGGHL-------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL             D     D L+         A    +KNTHGTGC+L++A+AA 
Sbjct: 172 KGGHLPLNAQRQKPTSDEDAAIVVDILYDGVEVTLIEANFSRSKNTHGTGCSLASAIAAN 231

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
                     V+EA  ++ + +  +  L  G G GP++HFH+ +
Sbjct: 232 LASEMEMTRAVREACRYVEAGINTSTDL--GKGNGPINHFHSLY 273


>UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=D1UAF8_9DELT
          Length = 458

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 101/247 (40%), Positives = 128/247 (51%), Gaps = 5/247 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT + LG YG SVITAL AQNTR V  +      FVA QL +V  D+++D  K G
Sbjct: 21  IQADLKTIAMLGGYGASVITALTAQNTRAVTGIQAPTAKFVARQLQTVLDDIQVDGAKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    I+ A+A  L   +   +V+D V +A SG  LL   AV  +   + P   L+TPN
Sbjct: 81  MLFSEPIIRAIAPILSARRF-PLVVDPVCVATSGAKLLKAEAVDAMVDLIFPLADLVTPN 139

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE-QRF 198
            PEA  L      R   ++    R LL MG  AVL+KGGH D     DW      E   F
Sbjct: 140 RPEAE-LFTGVEIRDRDDVFRAARILLDMGPRAVLIKGGHADSLAVTDWFVAAGAEPVPF 198

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
              R+ T  THGTGCTLSAA+A    +       +  A+ +L+ AL  A    +G G GP
Sbjct: 199 MQQRVDTACTHGTGCTLSAAIATGLGQGMEMDAAILRAQKYLNLALRAA--YRLGEGGGP 256

Query: 259 VHHFHAW 265
            +H   W
Sbjct: 257 PNHLAPW 263


>UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella succinogenes
           RepID=Q7M9P0_WOLSU
          Length = 261

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 92/262 (35%), Positives = 142/262 (54%), Gaps = 7/262 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D SGGAGIQAD+KT  A G +  + +T + AQNT GV+    +    V
Sbjct: 1   MK--VVLTIAGSDSSGGAGIQADIKTAEAFGCFSATALTVITAQNTLGVREAMPLGASLV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSP 119
            +Q+++V  D  ++  KIGML +T+ +  V E L +  ++  VVLD V ++++G  LL  
Sbjct: 59  RSQIEAVMEDFSVEAIKIGMLYDTETILGVGEFLIQNALKIPVVLDPVAISQAGSKLLLD 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+ +L   L P  +++TPNL E     +     T + + E+G         A ++K   
Sbjct: 119 EAIRSLAD-LFPLATVVTPNLKETELFWNLDQEPTLEILRERGVEFARERGVAFVVKNLR 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +D +S D+L   EG   F  P +    +HGTGC+ S A+A L     +  + V+EAK +
Sbjct: 178 KED-RSVDYLIQEEGIASFCTPYVKNGQSHGTGCSFSMAIACLLALGLSLPEAVKEAKDY 236

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+ +A  L  G G GP+ H
Sbjct: 237 IYKAMLEAPFL--GRGAGPILH 256


>UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase);
           hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)
           n=10 Tax=Actinomycetales RepID=Q0RDL7_FRAAA
          Length = 291

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 96/244 (39%), Positives = 141/244 (57%), Gaps = 5/244 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  A G +G S + A+ AQN+ GV  V+ +  + V AQ+ +V  D+ +D  K G
Sbjct: 49  IQADLKTMLAFGVHGMSAVVAVTAQNSLGVHGVWDLPAEAVRAQIRAVVDDIGVDAVKTG 108

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+   +V  VA  L+R     +V+D V ++K GDPLL+P AV  +R  L+P  ++ TPN
Sbjct: 109 MLSSAALVALVATELERVGA-PIVVDPVGVSKHGDPLLAPDAVDVVRRELMPLATIATPN 167

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L E   LL     R E ++     ++LA+G   VL+KGGHL  + + D L     E    
Sbjct: 168 LDEV-RLLTGVAVRDETDLPRAAAAMLALGPRWVLIKGGHLPGD-AVDLLTDGSTEILLR 225

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + R+  ++THGTGCTL++A+A+   R  +    V+ AK ++S ALA      +G GIGPV
Sbjct: 226 SRRMDRRHTHGTGCTLASAIASRMARGDSPTQAVRAAKEYVSGALAAG--FPLGAGIGPV 283

Query: 260 HHFH 263
            H +
Sbjct: 284 DHGY 287


>UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium Ellin514
           RepID=B9XCM9_9BACT
          Length = 264

 Score =  273 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 87/244 (35%), Positives = 135/244 (55%), Gaps = 10/244 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+ALG +G S IT + AQN + +  +    P  V  Q+++VF ++     K G
Sbjct: 23  IQADLKTFAALGVHGTSAITCITAQNPKRLLGIEACSPGIVRQQMEAVFEELPPGAAKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+++VA   +  +   +V+D VM++ SG  LL P+A+  L+ +LLP  +L+TPN
Sbjct: 83  MLYSEEIIKSVAGFFKSKRQTPLVVDPVMISTSGKRLLKPTAMRALQEKLLPLATLVTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD-EQSPDWLFTREGEQRF 198
           L EA  LL      + ++M    R L      A LMKGGHL   +++ D  F  + E   
Sbjct: 143 LDEANVLLGKAP-DSIEDMRGAARELHKRFGCAWLMKGGHLKGAKEAADVFFDGKEELLL 201

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
           T+  +   +THGTGCT SAA+ A        ++ V  AK ++S ++A++D +        
Sbjct: 202 TSRFVKGVSTHGTGCTYSAAITAYLALGLELSEAVTMAKHYISESIAKSDRVA------- 254

Query: 259 VHHF 262
            +HF
Sbjct: 255 -NHF 257


>UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidine phosphate
           kinases n=1 Tax=Pichia pastoris GS115 RepID=C4QXJ6_PICPG
          Length = 557

 Score =  272 bits (697), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 92/293 (31%), Positives = 157/293 (53%), Gaps = 29/293 (9%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           ++    LT+AG+DPSGGAGI+AD+KT SA    G S I AL AQNT GV++V + +  F+
Sbjct: 26  VRVPTVLTLAGSDPSGGAGIEADIKTISAFHCLGLSAINALTAQNTTGVKNVLQTDERFL 85

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSP 119
              L ++F D+RID  K GM+     V+ +   L ++ + + +V+D V+ + SG  L   
Sbjct: 86  TQLLQALFEDMRIDAIKTGMMTSKA-VKLLPFYLDKFHRGKPLVIDPVLSSTSGFDLGKL 144

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQ----------EMLEQGRSLLA-M 168
             + +  S    + ++ITPN  EA  ++ A    +            ++    + L   +
Sbjct: 145 DVLKSSISTFFAKATVITPNFIEAKKIMCAIQGISFDTFDLPVNGINDLKALAKFLQQNI 204

Query: 169 GCGAVLMKGGHLDDEQ--------------SPDWLFTREGE-QRFTAPRIMTKNTHGTGC 213
           GC +VL+KGGH+  ++                + L+ + G+   F +    +K THGTGC
Sbjct: 205 GCQSVLVKGGHIPWDEDFRPSDITGKPPRYLTEVLYEQSGDVTVFKSDFNRSKFTHGTGC 264

Query: 214 TLSAALAALRPRHTNWADTVQEAKSWLSSALAQAD-TLEVGHGIGPVHHFHAW 265
           TL++A+AA   R  + +++VQ + S++ +++  AD +L  G G GP++H +  
Sbjct: 265 TLASAMAANLARGLSISESVQLSISFVQNSIKYADKSLGSGTGYGPMNHLYNI 317


>UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobacillales
           RepID=A8YTJ6_LACH4
          Length = 270

 Score =  272 bits (697), Expect = 8e-72,   Method: Composition-based stats.
 Identities = 96/261 (36%), Positives = 137/261 (52%), Gaps = 5/261 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A+TIAG D  G AG+ ADL  F   G YG  ++TA VA NT G+ +   +  DF+  Q D
Sbjct: 8   AVTIAGNDSDGSAGMPADLHAFYDRGVYGMGLMTAAVAGNTTGIFAQQIMPVDFIQKQFD 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            +  D +I   K GMLA  +I++ VA+ L++Y +  +VLD V++ K G  LL   A  T 
Sbjct: 68  VLNDDFKISAAKTGMLANKEIIDCVADNLEKYDMGKIVLDPVIITKHGATLLDDDAYQTF 127

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE-Q 184
             +LLP   +ITPN  E   L        ++E+    + L  MG   VLMKG H  D+ +
Sbjct: 128 LDQLLPLADVITPNFYEQQKLTGMK-LENKEEIHAGAKKLQEMGAKNVLMKGRHDADQAE 186

Query: 185 SPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
             D L T +G    FT P   T   +GTG TLSA +AA   +  +  D V+  K +   A
Sbjct: 187 VADILLTEDGNFHEFTKPHFKTDRVNGTGDTLSAVIAAELAKGKSIIDAVKIGKDFTYEA 246

Query: 244 LAQADTLEVGHGIGPVHHFHA 264
           ++    + VG   GP++H+ A
Sbjct: 247 ISH--PINVGSKWGPINHWAA 265


>UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NFK8_METST
          Length = 259

 Score =  272 bits (696), Expect = 9e-72,   Method: Composition-based stats.
 Identities = 79/247 (31%), Positives = 133/247 (53%), Gaps = 7/247 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +  ++TIAG DPSGGAGI AD KTF A G Y   V+TA+ AQN   V  +  ++ D +
Sbjct: 6   MNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLI 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +++D + S   I   K GML   DI++ V+ +++ Y ++ VV D VM+++SG  L   S
Sbjct: 66  ESEIDEILSVYPIRYIKTGMLYSGDIIKLVSRKIKEYDLRAVV-DPVMVSESGGDLTGNS 124

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  +   L+    +ITPN+ EA  L +     +E++M+     L      +V++ GGH+
Sbjct: 125 FIEYMNKYLVKNSFIITPNIHEAEKLSNKT-ITSEEDMISVAEKLSKD--NSVVITGGHM 181

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D L+  +   R     I + NTHGTGCT S+A+ +      N  ++ +++  ++
Sbjct: 182 QGN---DILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFI 238

Query: 241 SSALAQA 247
            +++   
Sbjct: 239 RNSIKYG 245


>UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodesulfovibrio
           yellowstonii DSM 11347 RepID=B5YFN2_THEYD
          Length = 254

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 84/257 (32%), Positives = 141/257 (54%), Gaps = 7/257 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   ALTI  +DP+ GAGIQ DLK F +L  YG S++TA+ AQ+T    SV+ +  + +
Sbjct: 1   MKI--ALTIGASDPTSGAGIQMDLKVFHSLEVYGLSILTAVTAQSTIEFSSVFPLPEEII 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q +++  D++   TKIGM+   +  + V   ++   I+N+V+D VM +  G  LL  +
Sbjct: 59  NSQFETLLKDLKPHGTKIGMIYSKEAFQCVISNIKNLNIKNLVIDPVMTSTLGAKLLENN 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL+  L+P    +T N+PEA AL +    R E ++ E  + L  MG    ++KGGH 
Sbjct: 119 ALKTLKEELIPLSMAVTANIPEAEALTELKIERIE-DLYEASKQLYQMGTKFAIIKGGHF 177

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           + +++ D L+  +   +    +I     HGTGC  S+A      +  N  +  + +K ++
Sbjct: 178 E-KKAIDILYDGKNFYKIDGKKI-PGQFHGTGCAFSSAFVCFLCKGYNPLEAFKASKDFV 235

Query: 241 SSALAQADTLEVGHGIG 257
             A+    +L++G GI 
Sbjct: 236 RKAIEN--SLKLGQGIN 250


>UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=21
           Tax=Bacteria RepID=Q03NS0_LACBA
          Length = 272

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 97/261 (37%), Positives = 148/261 (56%), Gaps = 5/261 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAGTD  GGAGI ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q
Sbjct: 7   PQTLTIAGTDSGGGAGIMADLKTMQACQVFGAAVVVAVTAQNTLGVQDFMALPQKLIDEQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             S+ +D++I   K GMLA+   V  V E L++Y    + +D VM+AK G  LL+  AV 
Sbjct: 67  FASLAADLKIRACKTGMLADAAHVHGVVENLKKYDFGLLTVDPVMIAKGGAALLADDAVT 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDD 182
           T+R  L+P   ++TPNLPEA  L         + M     +L  +G   V++KGGH    
Sbjct: 127 TVRDELVPLADVLTPNLPEAERLTGLT-ITDNRGMEAAAMALQDLGAKNVVIKGGHEATP 185

Query: 183 EQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           +Q+ D++   +G     +A R+ T  THGTG TLS+ + A   +  ++   ++ AK +++
Sbjct: 186 DQASDFVLLVDGRSFWLSAARMDTVRTHGTGDTLSSCITAALAKGEDFETAIRIAKDFVT 245

Query: 242 SALAQADTLEVGHGIGPVHHF 262
           +A+  A+ + VG+G GP++H+
Sbjct: 246 AAI--ANPIAVGNGHGPLNHW 264


>UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionibacterium acnes
           RepID=D1Y931_PROAC
          Length = 569

 Score =  271 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 114/261 (43%), Positives = 152/261 (58%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDPSGGAG  AD K+  A G Y  +V+T+LVAQNT GV++++    DF+  Q
Sbjct: 61  PRVLSIAGTDPSGGAGTAADTKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQ 120

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  DVRID  K GML   +IV+AVA  L  ++   VV+D VM+A SGD LL+P A A
Sbjct: 121 LAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVVVDPVMVATSGDRLLAPDAEA 180

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R     + ++ITPN+PE A L  +  A T ++ +EQ R   A    AV++K GHL+ +
Sbjct: 181 AMRE-FCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQ 239

Query: 184 QSPDWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +  +   T EG      A R+ T NTHGTGC+LS+ALA          D +     WL  
Sbjct: 240 RVDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHE 299

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           A+     L VG G GPV H H
Sbjct: 300 AIQYGSALNVGKGHGPVDHSH 320


>UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DKQ9_LACTC
          Length = 570

 Score =  270 bits (692), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 86/278 (30%), Positives = 137/278 (49%), Gaps = 15/278 (5%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    +T+A +DPSGGAGI+ADLKTF+A   YG + + AL AQ   GV +++ I  +   
Sbjct: 29  RLPTVMTVATSDPSGGAGIEADLKTFTAHRCYGLTGMAALTAQTPEGVYAIHEIPKEHFK 88

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI---QNVVLDTVMLAKSGDPLLS 118
             LDS   D+R+D  K GML +   VE + E           ++V+D V++A SG  L+S
Sbjct: 89  LTLDSCLRDMRVDAIKTGMLTKPA-VEVLYETFSAMPADARPHLVVDPVLVATSGSTLVS 147

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAP--HARTEQEMLEQGRSLLAMG-CGAVLM 175
             +V      L P  +L+TPN  EA  +L        + +++++    L     C  VL+
Sbjct: 148 DQSVIDFIKTLSPLATLLTPNAYEAGRILGRESLELNSVEDLIDVACELQKTTLCPNVLL 207

Query: 176 KGGHLDD------EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNW 229
           KGGH         ++  D L        + +    ++NTHGTGCTL++A+A+        
Sbjct: 208 KGGHAPWVDSNGQKRVTDVLRLGNKTVLYRSVFCTSENTHGTGCTLASAIASNLAHGEAL 267

Query: 230 ADTVQEAKSWLSSALAQADTLEVGH--GIGPVHHFHAW 265
              V     ++ +A+    T+   H    GP++H +A 
Sbjct: 268 QHAVFGGIQYVHNAIEIGCTVTQPHVKKNGPINHVYAI 305


>UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3DWC5_METI4
          Length = 280

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 86/253 (33%), Positives = 139/253 (54%), Gaps = 4/253 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    L I G+D S GAGIQ DLK  + LGAY  +VIT +VA++   V+S+Y +    + 
Sbjct: 23  KMNGILIIGGSDCSCGAGIQGDLKIITCLGAYATTVITCVVAEHPGRVESLYHLPSSIIE 82

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSPS 120
           +Q  S+     ID  KIGML + ++ + + E +++++I   +V+D V+ A +GD L  P 
Sbjct: 83  SQFHSILDFFPIDAIKIGMLYKKELPQKIVELIRKFKINAPIVVDPVLAAGNGDSLAEPG 142

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L   L P  +++TPN+ EA  LL      + ++ML   + L      + L+KGGHL
Sbjct: 143 MEEELARNLFPLATVVTPNIEEAE-LLSGLRIESPEDMLRVAQDLSEQYSTSFLIKGGHL 201

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            D+ + D L+ +    +F  PRI+  N HGTGC+L++A A    +  +    V++AK+ L
Sbjct: 202 QDKTTIDVLYHKGIAHKFELPRILHANPHGTGCSLASATAVFLAQGLDLPKAVEKAKAKL 261

Query: 241 SSALAQADTLEVG 253
              +     L++G
Sbjct: 262 YEKIKS--QLQIG 272


>UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phosphate
           pyrophosphorylase fused protein ThiE n=4 Tax=Legionella
           pneumophila RepID=Q5ZV72_LEGPH
          Length = 495

 Score =  268 bits (687), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 90/254 (35%), Positives = 135/254 (53%), Gaps = 5/254 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+    TIAG D SG AG+ AD++TFS L    CSVITA+ AQN   + +V  I  D V
Sbjct: 8   MKKPIVWTIAGVDSSGLAGVHADMETFSRLNVRACSVITAVTAQNAHSIIAVEEISRDQV 67

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AAQ  ++  +++ D  KIGML  T I E +A  L+ Y+   VVLD ++ + SG  L  P 
Sbjct: 68  AAQCRALELNLKPDAIKIGMLCSTPICEEIAYFLKGYE-GFVVLDPIITSSSGTNLFFPD 126

Query: 121 AVATLRS--RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
                 +  +L P +++ITPN  EA  +L+     + Q+++     LL++G   VL+KGG
Sbjct: 127 LQQHKNNLIQLFPYITIITPNRIEAEIILN-RSIYSYQDIINAASDLLSLGAKQVLLKGG 185

Query: 179 HLDDEQ-SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H+ D   S D+    +        R    N  GTGC LS+AL A      +  D +  AK
Sbjct: 186 HVKDNSFSQDYWTDGKESFWIANRRFPETNYRGTGCVLSSALTACLALGYSIKDAIVIAK 245

Query: 238 SWLSSALAQADTLE 251
            +++  + Q+  ++
Sbjct: 246 MYVNRGIRQSIEID 259


>UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=B8IYN0_DESDA
          Length = 269

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 96/244 (39%), Positives = 132/244 (54%), Gaps = 6/244 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  ALG YG SVI AL AQN +GV  ++  +PDFVA QL +V     +   K G
Sbjct: 21  IQADLKTIMALGGYGMSVIAALTAQNGQGVTGIHAPDPDFVALQLCTVLDGFPVAAAKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    I++A+A  L++     +V+D V +++SG  LL   AV  L   +LP   L+TPN
Sbjct: 81  MLFSAPIIKAIAPILRKRDF-PLVVDPVSISQSGSVLLQEDAVKALVQEILPGCDLLTPN 139

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE--QR 197
            PEA  L +        +    G  LL MG  AVL+KGGH++           EG+  + 
Sbjct: 140 RPEAEMLTNMT-IDNLDDAAAAGEKLLQMGARAVLIKGGHMESNVVVTDCLCMEGQAPKH 198

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
               ++ T N HGTGCTLSAA+A    +       V  A+ +L+ AL +  +   G+G G
Sbjct: 199 LPQAKVETVNNHGTGCTLSAAIATGLGKGLPLQVAVTRAQEFLNLALRR--SYSPGNGCG 256

Query: 258 PVHH 261
           PV+H
Sbjct: 257 PVNH 260


>UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=C8WXY2_ALIAD
          Length = 297

 Score =  267 bits (684), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 100/244 (40%), Positives = 135/244 (55%), Gaps = 4/244 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT      YG SV+TA+ AQNT GVQ+VY +  D V AQ +SV  D+  D  K G
Sbjct: 26  IQADLKTAHQFDVYGMSVLTAVTAQNTVGVQAVYPLPVDIVRAQFESVRDDLGFDAIKTG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +   + AVA+ L       +V+D VM+AK G+ LL P  VA +  R+LP   + TPN
Sbjct: 86  MLGDRAAIHAVADALAGVDC-PIVVDPVMIAKGGEALLHPDDVAAVIERMLPLAFVATPN 144

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQSPDWLFTREGEQR 197
            PEA  L   P  R+  +      +L  +G    ++KGGHL+     + D +F       
Sbjct: 145 TPEAERLTGIP-IRSLADAARAAEALAGLGAQYAVVKGGHLEGAGHLAIDVVFHDGAWTF 203

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F APR+ +  THGTGCT S+A+AA   R     + +  AKS++S A+A A   +VG G G
Sbjct: 204 FAAPRVPSHKTHGTGCTFSSAIAACLARGARPLEAIAAAKSFISRAIAAAADWDVGRGHG 263

Query: 258 PVHH 261
           P  H
Sbjct: 264 PTDH 267


>UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus
           RepID=A5DVD5_LODEL
          Length = 585

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 97/299 (32%), Positives = 143/299 (47%), Gaps = 45/299 (15%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +K    LTIAG+D SGGAGI+ADLKTFSA   YG + ITAL AQNT GV++      + V
Sbjct: 16  VKLPVVLTIAGSDSSGGAGIEADLKTFSAFDVYGMTCITALTAQNTTGVKTYKETSRELV 75

Query: 61  AAQLDSVFSDV-------RIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKS 112
              L +   D+        +   K GML ++ I     E L ++ ++  +V+D VM+  S
Sbjct: 76  HEILKANLEDMYENEEKGPLKVIKTGMLTKSAI-----EELAQFDLKIKMVIDPVMVTTS 130

Query: 113 GDPLLSPSAVATLRSRLLPQVSLITPNLPEAA----ALLDAPHARTEQEMLEQGRSLLAM 168
           G  LL    V      L+    L+TPN  EA      L  +   +   E ++    L  M
Sbjct: 131 GSKLLDHEGVKLCVDNLMKNAFLVTPNFVEAETIYKILGKSAQVKQLDEFIKFTVDLQKM 190

Query: 169 -GCGAVLMKGGHL-----------------------DDEQSPDWLFTREGE--QRFTAPR 202
            GC  +L+KGGH+                          +  D L+  E +    F +  
Sbjct: 191 VGCKNILVKGGHIPFDANGKVVEDTTAEGQAQPQSNPGLKVIDVLYESENDVVTIFESKY 250

Query: 203 IMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           I + N+HGTGCTL++A+AA   + T+ AD+V     ++   + +   L  GHG GP++H
Sbjct: 251 IESDNSHGTGCTLASAIAANIAKGTSLADSVAIGIDYIHQGMLKMSKL--GHGKGPLNH 307


>UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridia
           RepID=A4XG68_CALS8
          Length = 259

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 88/256 (34%), Positives = 132/256 (51%), Gaps = 4/256 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++   L IAG DPS GAGI  D K   +LG +  SVIT L  Q T  V     I+PDF 
Sbjct: 1   MRK--VLVIAGFDPSCGAGIVLDTKVVRSLGEFAASVITCLTVQTTERVYDALPIDPDFF 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL  +  D+  D+ KIG+L   +I   V   ++RY ++N+V D V+ + SG       
Sbjct: 59  EYQLQKIIEDIEPDSVKIGLLGSEEITRVVLRNIRRYNLKNIVCDPVLKSTSGFEFGKDK 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQG-RSLLAMGCGAVLMKGGH 179
            V  L+S  L   S+ITPN  EA  + D      E+++L    + +  MG  + ++KGGH
Sbjct: 119 FVEFLKSEFLKACSVITPNKTEAEVIFDMKIENFEEDILNSIQQKMNKMGIKSCVLKGGH 178

Query: 180 LDDEQSPDWLFTREGEQRFTAPRI-MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           +D   + D L T+    R +A +   T N HGTGC  S+A A    +  N  DT+++ K 
Sbjct: 179 VDGHLAEDVLITQTKIYRVSAKKKGSTDNIHGTGCAFSSAFATFLAKGYNMYDTLKQTKD 238

Query: 239 WLSSALAQADTLEVGH 254
           ++S+ +  +  +  G 
Sbjct: 239 FVSNLIYNSIKIGKGR 254


>UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=11
           Tax=Helicobacter pylori RepID=THID_HELPJ
          Length = 269

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 108/264 (40%), Positives = 151/264 (57%), Gaps = 7/264 (2%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L+IAG+D  GGAGIQADLK F   G +G SVIT + AQNT+GV  VY +  + 
Sbjct: 1   MKVYPQVLSIAGSDSGGGAGIQADLKAFQTFGVFGTSVITCITAQNTQGVHGVYPLSVES 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V AQ+ ++  D  I   K+G L    I+E VA  L+       VLD VM+AK+G  LL  
Sbjct: 61  VKAQILAIRDDFSIKAFKMGALCNAQIIECVANALETCDFGLCVLDPVMVAKNGALLLEE 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+ +L+ RLLP+ +L+TPNLPE  AL     AR ++   +    L  +G    ++KGGH
Sbjct: 121 EAILSLKKRLLPKTNLLTPNLPEVYALTGV-QARDDKSASKAMGVLRDLGVKNAVIKGGH 179

Query: 180 LD---DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
            +    E S DW+F  + E   +A R  TKNTHGTGCTLS+ +  L  +  +  + + +A
Sbjct: 180 TEHFQGEFSNDWVFLEDAEFILSAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAITKA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVH 260
           K  L+  +     L +GHG GP++
Sbjct: 240 KELLTIIIQN--PLNIGHGHGPLN 261


>UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Saccharomycetaceae
           RepID=THI22_YEAST
          Length = 572

 Score =  266 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 77/276 (27%), Positives = 137/276 (49%), Gaps = 13/276 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    ++IAG+D SGGAG++AD+KT +A   Y  + +T L AQ    V   + I    V+
Sbjct: 44  KLPTVMSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAHNIPKKMVS 103

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY--QIQNVVLDTVMLAKSGDPLLSP 119
             LD+   D++ +  K GML   D +E + E+L +       +V+D V+ A S       
Sbjct: 104 QILDANLQDMKCNVIKTGML-TVDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPTGK 162

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTE-QEMLEQGRSLLA-MGCGAVLMKG 177
             V+ +  ++ P   ++TPN+ +   LL      ++ Q++LE  + L     C  +L+KG
Sbjct: 163 DVVSLIIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNILVKG 222

Query: 178 GHLD-----DEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWA 230
           GH+      ++   D L+    +    F    + T  THG GCTL++A+A+   R  + +
Sbjct: 223 GHIPCDDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLARGYSLS 282

Query: 231 DTVQEAKSWLSSALAQADTL-EVGHGIGPVHHFHAW 265
            +V     ++ +A+A    + +    +GP++H +A 
Sbjct: 283 QSVYGGIEYVQNAIAIGCDVTKKAVKVGPINHVYAV 318


>UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas mobilis
           RepID=C8WAW8_ZYMMN
          Length = 283

 Score =  265 bits (679), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 86/244 (35%), Positives = 136/244 (55%), Gaps = 5/244 (2%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+++ + LG +  + IT+L AQNT+GV ++  + P  V AQ+D+V +D+ +   KI
Sbjct: 29  GIQADIRSITMLGGHALTAITSLTAQNTQGVSAIDVVSPQMVIAQIDAVVTDIGVSAIKI 88

Query: 79  GMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           GM+   ++  AVA+ L++     VVLD VM+A SG  L     +     RL+ +  LITP
Sbjct: 89  GMIGSGEVAVAVADYLEKIPNIPVVLDPVMVATSGSALADKKTIQAF-DRLMYRADLITP 147

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR- 197
           N+PE   L       ++  ++   + L       +L KGGH + E   D L   +GE   
Sbjct: 148 NIPELEVLTK-QDCSSDASLIAAAQQLARHYDCPILAKGGHGEGEILTDRLVMPDGEVIS 206

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           +   RI T+NTHGTGC+LS+A+A    +     + +  A+ ++ +AL +A +L  G G G
Sbjct: 207 WQDSRIPTQNTHGTGCSLSSAIATSLGQGLPLKEAITRARQYIRTALEKAPSL--GKGHG 264

Query: 258 PVHH 261
           P+ H
Sbjct: 265 PIGH 268


>UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6K2F3_SCHJY
          Length = 505

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 87/279 (31%), Positives = 144/279 (51%), Gaps = 20/279 (7%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              +T+AG+D SGGAGIQADLK FSA   YG + +TA+ +QNT GV  V+ + P  V  Q
Sbjct: 3   PACITVAGSDCSGGAGIQADLKVFSAHSVYGMNAVTAITSQNTVGVNGVFPVPPAVVKKQ 62

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +++  +D+  +  K GML   +I++ + + +  + I++V+ D ++  K G  L+ P  V 
Sbjct: 63  IEACLTDIECNVLKTGMLFTKEILDVLIDVINNFHIKHVIADPLISTKKGMLLVKPEYVK 122

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHART-----EQEMLEQGRSLLAMGCGAVLMKGG 178
              ++ +P   LITPNL EA  LL      T       ++    + L+A GC +VL+K  
Sbjct: 123 VFVTKFIPLTELITPNLSEALILLKQLTGETIGVHNASDVELIAKKLVAAGCKSVLIKCN 182

Query: 179 HL---------DDEQSPDWLF----TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR 225
           +L          ++ S  W        +  +      +  ++ HGTGCTL++A+AA R  
Sbjct: 183 NLWFDDDLKCTSNKDSAVWFVYVYGDAKTSKIIPKKWLAARSAHGTGCTLASAIAANRAN 242

Query: 226 HTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
             +  D    A +++ +AL    + ++GHG   + H  A
Sbjct: 243 GLSLYDAALNAAAYVQAALE--KSFQLGHGANSLDHVFA 279


>UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bacteroides
           RepID=B3JHT8_9BACE
          Length = 288

 Score =  265 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 84/264 (31%), Positives = 137/264 (51%), Gaps = 7/264 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K      IAG++P G AG+QAD+K+ SA G Y    IT +V ++T  V+S+  I  + V 
Sbjct: 6   KLYKVFLIAGSEPLGTAGMQADIKSISACGGYAAGAITCIVDEDTIKVKSIQTIPVEMVV 65

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           +Q  S   DV  D  K GML   ++V A+ + +++ Q   +V+D VM++ +GD LL   A
Sbjct: 66  SQTYSFLEDVGADCIKTGMLYSQELVTAIGDVVKK-QSIPIVVDPVMVSSAGDKLLQDDA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +   +  L P  ++ITPN  EA  LL      T+  M E    L   G   V++K    D
Sbjct: 125 IQAYKDCLFPYSTIITPNRREADLLLGKSL--TKDNMKEYIPELSKWG-NCVIVKSI-ED 180

Query: 182 DEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +   D  +    +  + +   RI TKN +GTG T ++++A    R  +    V +A+++
Sbjct: 181 GDYLIDVFYNPISKCFKLYKKARIQTKNVNGTGDTFASSIATYLARGYDMNTAVDKAENF 240

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           + +A+     ++ G G GPV+ F+
Sbjct: 241 IYNAILYGSNVKFGSGYGPVYPFY 264


>UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Actinobacteridae RepID=D2NTJ0_9MICC
          Length = 590

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 117/282 (41%), Positives = 159/282 (56%), Gaps = 23/282 (8%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L+IAGTDPSGGAGIQADLK+ +A G YG  V T+LVAQNT GV+ V+    +F+ 
Sbjct: 45  RVPRVLSIAGTDPSGGAGIQADLKSIAASGGYGMCVTTSLVAQNTCGVREVFTPPLEFLT 104

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQL +VF DV +D  KIGML + D +  V   L  + +  VVLD VM+A SGD LL   A
Sbjct: 105 AQLAAVFDDVTVDAVKIGMLGDADTIRTVRTWLSEHPVPVVVLDPVMIASSGDRLLQAEA 164

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              LR  L+P V++ITPN+PE A L +   A+T  E  EQ  +L A     V++KGGHL 
Sbjct: 165 EQALRD-LVPLVNVITPNIPELAVLCEKEPAQTFDEAHEQAANLAAATGTTVIVKGGHLC 223

Query: 182 DEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRP----RHTNWAD----- 231
            + + +     +G       PR+ ++NTHGTGC+LS++LA        +H   A+     
Sbjct: 224 GQDAGNTAVFPDGTCAHVRTPRLDSRNTHGTGCSLSSSLATRLGVELLQHAEVAEHTAEQ 283

Query: 232 ----------TVQEAKSWLSSALAQADTLEV--GHGIGPVHH 261
                      +Q +  WL  ++A    L+V  G G GPV H
Sbjct: 284 SVLTSEDTHRALQWSTRWLHESIAAGAGLQVGSGEGHGPVDH 325


>UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadratum walsbyi DSM
           16790 RepID=Q18GX7_HALWD
          Length = 273

 Score =  264 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 97/265 (36%), Positives = 141/265 (53%), Gaps = 10/265 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIA +D SGGAGIQADLKT +  G YG SV+ +  AQNT+GV S + + P  + 
Sbjct: 7   ELPYALTIASSDSSGGAGIQADLKTMTRFGVYGGSVVVSTTAQNTQGVDSTHVLPPAEIR 66

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+SV  D+ ID  K+GMLA  + +E V + L  Y    VV+D VM+A SGD LL+ +A
Sbjct: 67  TQLESVAEDIDIDAIKLGMLATAEAIETVDDCLMGYD-GPVVIDPVMVATSGDRLLAENA 125

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +    + L    +L+TPN  E  AL       T +      +     G  AVL KGGH++
Sbjct: 126 IDVY-TDLFAHATLLTPNADETEALTGVWP-DTVEARERAAKQFFDWGVDAVLFKGGHIE 183

Query: 182 DEQSPDWLF----TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            +++             +   T  R+ T +THG+GCTL++A+AA      +    V +  
Sbjct: 184 TDENTVQDILIGADAGTQLTITGDRVETAHTHGSGCTLASAIAAGLAHDVDIETAVSDGV 243

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++ +AL  A T+      G V+H 
Sbjct: 244 EFVQTALQNAATIGA---NGSVNHL 265


>UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosarcinales
           RepID=A0B7E3_METTP
          Length = 452

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 98/253 (38%), Positives = 141/253 (55%), Gaps = 12/253 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+ALG +G SVITA+ AQNT GV+ V+ I  + +A+QLD++  D  I   K G
Sbjct: 19  IQADLKTFAALGVHGLSVITAVTAQNTLGVREVFPIPAEMIASQLDALVEDFDISWAKTG 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   D +  VAERL+  +   VV+D V+ A++G  L++  A+ TLR  L+P  S+ITPN
Sbjct: 79  MLFSPDAISLVAERLRELRCS-VVVDPVIAAEAGGSLIAEGAILTLRDELIPVASVITPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-------DEQSPDWLFTR 192
           + EA A+         +   E    +L MG  AV++ GGHLD        ++  D L T+
Sbjct: 138 IFEAEAITGVKVVD-LESAREAAMRILDMGARAVVITGGHLDCRAAGMPADECVDLLVTK 196

Query: 193 EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEV 252
           +     +  R    N HG GCT SAAL AL     +  D V++A ++ + ++  +    V
Sbjct: 197 DAVACVSGKRREGGN-HGVGCTYSAALTALLSMGMSLDDAVRQAHNFAARSIEGSR--PV 253

Query: 253 GHGIGPVHHFHAW 265
           GHG  PV    + 
Sbjct: 254 GHGAAPVDQTASL 266


>UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine archaeal group 1
           RepID=A9A225_NITMS
          Length = 432

 Score =  263 bits (673), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 75/250 (30%), Positives = 137/250 (54%), Gaps = 4/250 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +N L+I G+DPS GAGIQ+D++ FSALG +  +VITA+ +QNT     V  +    +  Q
Sbjct: 1   MNILSIGGSDPSSGAGIQSDIRVFSALGVHTLTVITAITSQNTSKFGMVEPVSSKILQKQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L+SVFSD +I+  KIGM+  + I++ + ++L++ +I  +V+D V+ + +G  L+  +A  
Sbjct: 61  LESVFSDFKINGVKIGMVYNSKIIKIIHQQLKKLKI-PIVVDPVIRSTTGGSLIENNARK 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
             +  ++P  ++ITPN  EA  LL      T+    +  + +  MG   V + G   + +
Sbjct: 120 DFQKYIVPLATIITPNKKEAE-LLTKMKISTKNTPEKVAKEIQNMGAKNVTITGI-EEKK 177

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D++  +  +   +  +I  K  HG+GC  SAA+     +  +  +++  AK +   +
Sbjct: 178 KVSDFVLEKNSKYIISGEKI-PKINHGSGCIHSAAVVYSLAKKKSIKESLYFAKKFTYKS 236

Query: 244 LAQADTLEVG 253
           +  A  +  G
Sbjct: 237 IKNAKKIGKG 246


>UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanocorpusculum labreanum
           Z RepID=A2SRR0_METLZ
          Length = 266

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 86/247 (34%), Positives = 123/247 (49%), Gaps = 3/247 (1%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           TIAG+DPS GAGIQ DLKT +A G +G +VI AL AQN   V     +   F+  Q+D++
Sbjct: 6   TIAGSDPSAGAGIQVDLKTMAACGVWGMTVIAALTAQNATHVLDSSSVPAAFIKKQIDAL 65

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
             D  I   K GML   + V  VA  +     +N+V+D V+LA     LL  +    L +
Sbjct: 66  EEDFPIGCYKTGMLKNAETVNIVAASIPE--GRNLVVDPVLLATKEYRLLDEAGQERLVA 123

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPD 187
            LLP+ ++ITPN+PEAAAL       +E  M E     +  G  A ++KGGH       D
Sbjct: 124 ELLPRTTVITPNIPEAAALSGITITGSE-SMEEAAYWFIDHGAKAAVIKGGHAHFRLGTD 182

Query: 188 WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
               ++G            + HG+GC  ++A+AA         D V EAK +++ A+  +
Sbjct: 183 VFADKDGIMLVEGEVAPFTDVHGSGCCYASAIAAHIALGYPVRDAVLEAKKFVTGAIKYS 242

Query: 248 DTLEVGH 254
                G 
Sbjct: 243 WEYAPGR 249


>UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=6 Tax=Coxiella burnetii
           RepID=A9NB66_COXBR
          Length = 479

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 2/250 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           ++    +I G+D SGGAG QAD+ T      +  S+IT + AQN   V  +   + D + 
Sbjct: 3   QKSIVWSIGGSDCSGGAGCQADILTCRDFNVHAASIITTITAQNAEQVLKINYCDSDLIQ 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+ ++   +     K+G+L   +IV AVA  L+ Y    VV D V+ + SG  L +   
Sbjct: 63  KQIQALKETLPPTVIKLGLLGTKEIVTAVASYLKNYS-GKVVCDPVLNSTSGVLLHASDY 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  L+  L P V L+TPN+PEA  L+      T  +++     LL  G  AVL+KGGHL 
Sbjct: 122 LDLLKKLLFPHVDLLTPNIPEAEILIQNK-IHTFSDIISAAHQLLKCGVSAVLLKGGHLI 180

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             ++ D+    + E      +I      GTGC LS+A+++      +  D +  AK ++ 
Sbjct: 181 GSKACDFFTDGKCEFWLAHTKIPKTRVRGTGCALSSAISSAIALGYSLKDAIVVAKMYVQ 240

Query: 242 SALAQADTLE 251
             + Q   + 
Sbjct: 241 QGIRQNFKVN 250


>UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular organisms
           RepID=Q7R735_PLAYO
          Length = 391

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 8/250 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            L+++G DP+GGAGIQAD++   A+G   C+VITAL  Q+T  V +V    PD   AQ  
Sbjct: 135 VLSLSGHDPTGGAGIQADIEAVGAIGCRACTVITALTIQDTSNVHAVQPQSPDAFLAQGR 194

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVAT 124
           ++  D+ +   KIG+L    I   VA  L        VVLD V+ A  G  L S   +  
Sbjct: 195 ALIRDLPVAAVKIGLLGSAGIAHCVATLLDELGGGVPVVLDPVLAAGGGTDLASEELIEA 254

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R+ LLP+  L+TPN+PEA+ L             E    L  +GC  VL+ G H   + 
Sbjct: 255 VRTELLPRAVLVTPNVPEASRLGGGATE------AENAERLRLLGCPNVLITGTHAPTDD 308

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             + L++  G++ +  PR+   + HG+GCTL+A +A            V+ A+ +   +L
Sbjct: 309 VVNRLYSSTGKRDYRWPRL-PYSYHGSGCTLAAXVAGYLALGHAMDAAVEWAQRFTWQSL 367

Query: 245 AQADTLEVGH 254
               T   G 
Sbjct: 368 RAGWTPGDGQ 377


>UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=Q6CV88_KLULA
          Length = 539

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 90/269 (33%), Positives = 146/269 (54%), Gaps = 8/269 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LT+AG+D SGGAG++AD+KT SA G Y  + ITAL  Q    V S    +   + 
Sbjct: 54  KLPGVLTVAGSDSSGGAGVEADVKTISAQGCYAMTCITALTCQTPGKVYSFINTDEQHIK 113

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
             L      +R D  KIGML     ++AV  +L + ++  +VLD VM+A SG PL S   
Sbjct: 114 EILGHNLRSMRCDAIKIGML-NLGALKAVVSQLDQIKV-PIVLDPVMVATSGSPLSSGDV 171

Query: 122 VATL-RSRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             +     L+ +V+LITPN+PEA AL+  ++   +T  +M+   + + A     VL+KGG
Sbjct: 172 WESSEIKLLMDKVALITPNIPEAKALIRDESYDLKTVSDMVALSKRVAADCRCNVLLKGG 231

Query: 179 HLD-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H   + +  D LF       + + R+ + N HGTGCTLS+ +A+    + +  + V ++ 
Sbjct: 232 HCPIEGKVIDVLFVDGQVYIYNSDRLNSVNLHGTGCTLSSCIASKLAYNVSLPEAVYQSI 291

Query: 238 SWLSSALAQADTLEVGHG--IGPVHHFHA 264
            ++ SA+   + ++V +    GP++H ++
Sbjct: 292 QYVHSAIICGENIKVTNCTENGPLNHIYS 320


>UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospira
           RepID=Q04W62_LEPBJ
          Length = 270

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 85/249 (34%), Positives = 131/249 (52%), Gaps = 8/249 (3%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+AL  +G S IT L +QN  G+  +  +  DF+  Q+ +V     + + K G
Sbjct: 23  IQADLKTFTALDTFGTSAITCLTSQNPSGITEILEVNADFLEKQILAVLDYFPVKSIKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQ----NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSL 135
           ML  T I+E  +  L   +      ++V+D VM++  G  LL  SA+  L ++L+P   L
Sbjct: 83  MLFSTAIIEKTSYLLSNRKNTEKNFSLVIDPVMVSTRGSKLLQESAIDILLTKLIPLADL 142

Query: 136 ITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ-SPDWLFTREG 194
           ITPNL EA  L     +++  EM +  +++       VL+KGGHL +E+ + D LF  + 
Sbjct: 143 ITPNLDEAEILTGKKISKSR-EMPDFAKAIFEKFKVPVLLKGGHLQNEEVALDILFDGKS 201

Query: 195 EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
             +F  P +     HGTGCT S+A+ +   R    A+ +Q AK +L +A+ Q+       
Sbjct: 202 ISKFEKPFVNGFYPHGTGCTYSSAITSYLARGEKLAEAIQLAKEYLHAAIEQSYAAGKDK 261

Query: 255 --GIGPVHH 261
                PV H
Sbjct: 262 TLNHTPVLH 270


>UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kangiella koreensis
           DSM 16069 RepID=C7R6N5_KANKD
          Length = 493

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 79/260 (30%), Positives = 131/260 (50%), Gaps = 6/260 (2%)

Query: 1   MK---RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK   +    + AG D SG AG  AD++T  ALGA+ C V TAL AQN++ V ++     
Sbjct: 1   MKVTGKPVVWSYAGLDNSGMAGQVADIRTIEALGAHACCVTTALTAQNSQRVVAINPSAK 60

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPL 116
           + + +QL+++    + +  K+G+L   + ++ +   L++      +V D V+ + SG   
Sbjct: 61  EQLQSQLEALQELGQPNAIKVGLLPSEESIQLLITYLEKASNPIQLVFDPVIESSSGTQF 120

Query: 117 LSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
           +    +  L  +LLP V++ TPN+ E A +      ++  ++  Q + LL  G  AVL+K
Sbjct: 121 MPDEVLEQL-EKLLPLVTVFTPNIDELARITG-QKIQSIDDIESQAKKLLESGTSAVLVK 178

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH   EQ+ D+   R+ +    + R  T NT GTGC LS+A+A       +  D V   
Sbjct: 179 GGHWPSEQASDFFVNRQHQFWLHSDRQETDNTRGTGCVLSSAIATALALDYSVEDAVVIG 238

Query: 237 KSWLSSALAQADTLEVGHGI 256
           K  L+  L  +  +    G 
Sbjct: 239 KMVLNQGLRHSYGIRDQKGP 258


>UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria RepID=C8X581_DESRD
          Length = 269

 Score =  261 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 104/249 (41%), Positives = 142/249 (57%), Gaps = 8/249 (3%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQ DLKT + LG +G SV+TAL AQNT GVQ V+ +   F+  Q++SV +D+  DT KIG
Sbjct: 18  IQTDLKTIALLGGHGTSVLTALTAQNTLGVQGVHPVPEAFIRQQMESVLTDIGTDTLKIG 77

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA   IV  VAE L+      +VLD VM+A SGDPLL+  A  +L+  L P  +++TPN
Sbjct: 78  MLATAGIVRTVAEGLRALTAAPLVLDPVMVATSGDPLLAEDARQSLQDNLFPLAAVVTPN 137

Query: 140 LPEAAALLDAPHARTE--QEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR 197
           L EA  L   P       ++       + A G   VL+KGGHL D+ + D LF       
Sbjct: 138 LGEAELLCGFPVTDRAGMEQAAAA---IHARGPAYVLLKGGHLVDD-AADLLFDGHQGIW 193

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
               R+ T +THGTGCT SAA+A    +  +    V +AK +++ A+A A  L  GHG G
Sbjct: 194 LPGHRVDTVHTHGTGCTYSAAIATFLAQSGDMVQAVTQAKRFITRAIAAAGPL--GHGRG 251

Query: 258 PVHHFHAWW 266
           P + + A +
Sbjct: 252 PTNPYAAVF 260


>UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SM66_NOCSJ
          Length = 270

 Score =  261 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 97/266 (36%), Positives = 144/266 (54%), Gaps = 9/266 (3%)

Query: 1   MKRINA-LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M+     LT+AGTD  G AG+ ADL TF+ALGA+G   +TA+ AQ+T GV +V  +  D 
Sbjct: 1   MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADH 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V AQ+D+V  D+ +   K GML   +I   VA+         +V+D V+   SG  L   
Sbjct: 61  VRAQVDAVLDDLPVAVAKAGMLGSAEIAGVVADL---PPGLPLVVDPVLRTTSGSVLADD 117

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           + VA  R  +LP+ +++TPNL EA  L     A +E+ +    R+L A+G  AV++ GG 
Sbjct: 118 ALVAAYRDHILPRCTVVTPNLAEARRLAG---AGSEEPLEHVARALQALGP-AVVLTGGD 173

Query: 180 LDDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            + +   D++    G       P + T N HGTGCT SAALA    R        + A++
Sbjct: 174 PESDWCRDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQA 233

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
           ++++AL ++    +G G GPV H  A
Sbjct: 234 FVAAALRRSAGWRLGRGRGPVAHTFA 259


>UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A1A9_NATTJ
          Length = 275

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 85/238 (35%), Positives = 134/238 (56%), Gaps = 3/238 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF ++G +G +V+T + AQNT GVQ+   +E   VA Q  SV  D+ I   K G
Sbjct: 21  IQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVAEQFKSVAEDMEISAVKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           ML+   I+E V++ L  +  +  +V+D V+ A SGD LL   AV+TL  +L+P   +ITP
Sbjct: 81  MLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQAVSTLLEKLIPISDIITP 140

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRF 198
           N+PEA  L       ++ ++ +    L   G  +VL+KGGH     + D  F  +    F
Sbjct: 141 NIPEAEILTGINIDHSK-DLQKAAHKLKEAGAKSVLIKGGHTSGN-ATDHFFWEDEYHTF 198

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
           +A R+   + HGTGCTL +A+ A   +  +   +++ AK +++ A+  + T+  G  +
Sbjct: 199 SAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYVTQAINNSFTIGEGSKV 256


>UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=59
           Tax=Bacteria RepID=THID_STRCO
          Length = 269

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 99/246 (40%), Positives = 141/246 (57%), Gaps = 5/246 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  ALG +G SV+TA+ AQN+RGVQ  + +  + V AQ  SV  D+ +   K G
Sbjct: 27  IQADLKTMLALGTHGMSVLTAVTAQNSRGVQGAWELPVEAVRAQYRSVVDDIGVQAVKTG 86

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  ++VE VAE L       VV D V ++K GD LL+ SA+ ++R+RLLP  ++ TPN
Sbjct: 87  MLSSAELVETVAELLAGTDAPAVV-DPVGVSKHGDALLASSALESVRTRLLPVATVATPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L E A L        E ++     ++LA G    L+KGGHL  + + D L     E    
Sbjct: 146 LDEVAQLTGV-RVDDETDLRRAAAAVLAFGPRWALIKGGHLAGD-AVDLLTDGSEEHWLR 203

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           APR+  ++THGTGCTL++A+A    +  +    V+ AK +++ A+       +G GIGPV
Sbjct: 204 APRLDNRHTHGTGCTLASAVACGLAKGQSVPVAVRAAKEYVTGAITAG--FPLGGGIGPV 261

Query: 260 HHFHAW 265
            H  A 
Sbjct: 262 DHGWAL 267


>UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria RepID=PDXK_STAES
          Length = 276

 Score =  260 bits (665), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQN-TRGVQSVYRIEPDF 59
           M     LTIAG+D S GAG+QADLKTF  L  YG   +T++V  +       V  I+ + 
Sbjct: 1   MALKKVLTIAGSDTSAGAGMQADLKTFQELDVYGMVALTSIVTMDKETWSHDVTPIDMNV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
              QL++  S +  D  K GML   DI++   +          V+D VM+ K  D +L+P
Sbjct: 61  FEKQLETAIS-IGPDAIKTGMLGTQDIIKRAGDVFVESGADYFVVDPVMVCKGEDEVLNP 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
                +   LLP+ +++TPNL EA  L       + ++M +  + +   G   V++KGG 
Sbjct: 120 GNTEAMIQYLLPKATVVTPNLFEAGQLSGLGKLTSIEDMKKAAQVIYDKGTPHVIIKGGK 179

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            LD ++S D  +  +   + T         HG GCT +AA  A      +  + +  AK+
Sbjct: 180 ALDQDKSYDLYYDGQQFYQLTTDMFQQSYNHGAGCTFAAATTAYLANGKSPKEAIIAAKA 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           +++SA+      ++   +GPV H
Sbjct: 240 FVASAIKNG--WKMNDFVGPVDH 260


>UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Alphaproteobacteria RepID=Q2W2C4_MAGSA
          Length = 270

 Score =  259 bits (663), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 108/249 (43%), Positives = 148/249 (59%), Gaps = 5/249 (2%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K  + LG +  + +TAL AQNT GV  ++ + PDFV AQ+ +V SD+  D  K 
Sbjct: 20  GIQADIKAVTCLGGFAATAVTALTAQNTLGVSGIHEVPPDFVRAQMAAVLSDIGADCIKT 79

Query: 79  GMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
           GMLA   IVE VA  L+       +VLD VM+AK G  LL+ SA   L  RL+P+  L+T
Sbjct: 80  GMLASAAIVETVALALEELAPAVPLVLDPVMVAKGGAALLADSAAGALVKRLVPRARLLT 139

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFT-REGEQ 196
           PN+PEA  LL     +    M    R LLA+G  AVL+KGGHL+ +   D L     G +
Sbjct: 140 PNIPEAEVLLGRA-IKGADGMEGAARDLLALGPKAVLLKGGHLEGDHLVDVLAEAGGGLR 198

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
           RFT  RI +++THGTGCTL++A+AA   +     + V+ A+++L  A+  A  L  G G 
Sbjct: 199 RFTGRRIASRSTHGTGCTLASAIAAGLAQGLGLVEAVERARAYLVRAIETAPGL--GSGH 256

Query: 257 GPVHHFHAW 265
           GP++H H  
Sbjct: 257 GPLNHGHTV 265


>UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S5F9_OSTLU
          Length = 478

 Score =  259 bits (663), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 115/271 (42%), Positives = 165/271 (60%), Gaps = 9/271 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   L +AG+D  GGAG+QAD+K   A GA+  + ITAL AQNT GV  V+    +F+
Sbjct: 1   MVRGKVLVVAGSDSGGGAGVQADVKAILAHGAFATTAITALTAQNTTGVHGVHAAPLEFI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+++V +D+  D  K GMLA      AVA+ ++R+++ NVV+DTVMLAK G  LL   
Sbjct: 61  EAQIEAVVTDLPPDACKTGMLANAATTRAVADAIERHRLTNVVVDTVMLAKGGASLLEAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQE-MLEQGRSLLAMGCGAVLMKGGH 179
           A+  +R RL P  ++ITPN+PEAAALL+        E M  + + L  +GC  VL+KGGH
Sbjct: 121 ALEVMRDRLAPLATVITPNVPEAAALLNLSEEEFVMETMATRAKELGKLGCQWVLLKGGH 180

Query: 180 LDD--EQSPDWLFTREG--EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           + D  E S D+L+         F++ RI T++THGTGCTL++++AA   +  +    V  
Sbjct: 181 VKDDAEMSVDYLYEANTGRTTTFSSARIDTRHTHGTGCTLASSIAASLAQRYDVPTAVHR 240

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHH--FHA 264
           AK ++S A+  +     G G GP++H  FHA
Sbjct: 241 AKRYISEAIRTSPGY--GAGHGPLNHLPFHA 269


>UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Desulfovibrionaceae RepID=Q1MQ91_LAWIP
          Length = 277

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 93/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT + LG +G SVITAL AQN  GV  ++  +P F+  QL++++    ++  K G
Sbjct: 26  IQADLKTIAILGGFGLSVITALTAQNGLGVTGIHTPDPSFIELQLNTIYKGFFVNVLKTG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    I+E V   +++ Q    V+D V +++SG  LL  +A+  LR+ +LP   L+TPN
Sbjct: 86  MLFSVPIIEIVKNIIKKQQTLA-VIDPVCVSQSGYQLLEHTAIDALRTHILPLAMLVTPN 144

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS----PDWLFTREGE 195
            PEA  LL      +E+++   G+ L+ MG  AVL+KGGH           DW   +   
Sbjct: 145 KPEAE-LLTEMQIESEKDIYIAGKRLIDMGAKAVLIKGGHFYKNNLVTNYVDWYIEKNST 203

Query: 196 --QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVG 253
                + P I TKN HGTGCTLSAA+A            + +A+++L+  L    +   G
Sbjct: 204 NPIPLSQPAIKTKNNHGTGCTLSAAIATYIGLGLELKKAILQAQTYLNYCLKF--SYTPG 261

Query: 254 HGIGPVHH 261
            GIGP +H
Sbjct: 262 KGIGPPNH 269


>UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria RepID=A7HV13_PARL1
          Length = 282

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 99/243 (40%), Positives = 141/243 (58%), Gaps = 4/243 (1%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K+ SA+G +  + +TA+  QNT GV  ++ +  D V AQ+ +V  D+  D  K 
Sbjct: 22  GIQADIKSVSAMGGFAMTAVTAITVQNTLGVHGIHEVPVDVVVAQMKAVMEDIGADAVKT 81

Query: 79  GMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
           GML   +IVEAVA +L        +V+D VM+AK G  LL  SAVA L+  L+P  +LIT
Sbjct: 82  GMLHSAEIVEAVAAQLSEENAPGFLVVDPVMIAKGGAALLEGSAVAALKEVLIPLATLIT 141

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR 197
           PN+PEA  L                 +LL +GC AVL+KGGHL  +   D L T+E    
Sbjct: 142 PNVPEAEVLTG-RSITDLASQKAAADALLGLGCDAVLLKGGHLSGDTLFDVLATQETVHT 200

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F++PRI T++THGTGC L++A+AAL  +       V+ A+ ++  A+  A     G G G
Sbjct: 201 FSSPRIDTRHTHGTGCALASAIAALLAQGVELTAAVEAARDYIHEAIRTAP--GFGKGHG 258

Query: 258 PVH 260
           P++
Sbjct: 259 PLN 261


>UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomycetales
           RepID=C7QH05_CATAD
          Length = 290

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 109/265 (41%), Positives = 151/265 (56%), Gaps = 6/265 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D  GGAGIQADLKT  A G +G SV+TA+ AQN+ GVQ  + +  + V  Q
Sbjct: 21  PRVLTIAGSDSGGGAGIQADLKTMLAHGVHGMSVLTAVTAQNSVGVQDFWALPIEAVERQ 80

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAV 122
             SV  D+ +D  K GMLA  ++   VA  +        VV+D V ++K GD LL+P A+
Sbjct: 81  FRSVVDDIGVDAVKTGMLASPELTSTVARLIGTLDPSVPVVVDPVSVSKHGDALLAPEAL 140

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             LR  LLP+ +++TPNL E   L+       E EM+   R+L  +G   VL+KGGHL D
Sbjct: 141 DALRGELLPRATVVTPNLDEV-RLITGLDVVAEPEMVAAARALADLGPRWVLVKGGHLSD 199

Query: 183 E-QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +S D L   +G E    APR   ++THGTGCTL++A+A+      +    V+ AK ++
Sbjct: 200 HPESVDLLVGPDGAEHWLRAPRHDNRHTHGTGCTLASAIASRLALGDDVPTAVRAAKEYV 259

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           +  +A      +G GIGPV H   W
Sbjct: 260 TGGIAAG--FPLGAGIGPVDHGWRW 282


>UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosphate kinase) (HMP-P
           kinase) n=7 Tax=Saccharomycetales RepID=A3LN87_PICST
          Length = 583

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 86/301 (28%), Positives = 138/301 (45%), Gaps = 45/301 (14%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D SGGAGI+ADLKTFSA   YG + I AL AQNT+ V++  +   + V   
Sbjct: 21  PAVLTIAGSDNSGGAGIEADLKTFSAHKVYGLTCIAALTAQNTQLVKTFEKTPKELVKNI 80

Query: 64  LDSVFSD---------VRIDTTKIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLAKS 112
           L   F D           +   K GML   + V  + + L   +  NV  ++D VM++ S
Sbjct: 81  LQLNFDDFLYGYEDSTQPLKVIKTGML-TEEAVHVIQDFLPDIKKHNVKLIVDPVMISTS 139

Query: 113 GDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAP----------HARTEQEMLEQG 162
           G  L     +    + L+    LITPN  EA AL +               +  + ++  
Sbjct: 140 GSSLFDSEGMKLCVNTLISGAYLITPNFVEARALWEIACGESAAIEKLTINSLDDFIDFV 199

Query: 163 RSLLA-MGCGAVLMKGGHLDDEQ-------------------SPDWLFTR--EGEQRFTA 200
           + L   +    VL+KGGH+  +                      D L+    +    F +
Sbjct: 200 KQLQKTLKSQNVLVKGGHIPWDSRTGKPFVGTNLADVEDSIVVLDVLYESEIDKATVFES 259

Query: 201 PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVH 260
             I TK++HGTGCTL++A++A   +  N  +++  +  ++   +      ++G+G GP++
Sbjct: 260 KYINTKDSHGTGCTLASAISANVAKGKNLKESISLSIDYIHKGMLSVGK-KLGYGNGPLN 318

Query: 261 H 261
           H
Sbjct: 319 H 319


>UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomonadaceae
           RepID=Q3BUP8_XANC5
          Length = 295

 Score =  257 bits (658), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 98/251 (39%), Positives = 141/251 (56%), Gaps = 14/251 (5%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+A   +G S ITAL AQ+TR V +V+     F+ AQ+D+ F+D  I   K+G
Sbjct: 49  IQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLSFLQAQVDACFADFEIQAVKLG 108

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA  D++  VA+ L+RY+   VVLD VM++ SG  LL  +A+  LR+RLLP  +L+TPN
Sbjct: 109 MLANADVIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLVTPN 168

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQSPDWLFTREGEQRF 198
            PEA  LL      +         +LL +G  AVL+KGGHL +  +  D       +  F
Sbjct: 169 TPEAE-LLTGRRIDSADAAEHATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVF 227

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG- 257
             PR+   + HGTGC+LSAA+AA   +  +  +  + A  +++ A+       +G   G 
Sbjct: 228 MHPRLQ-VDAHGTGCSLSAAIAAQLCQGLSLLNACEAAIDYVARAIR------IGQRPGH 280

Query: 258 ----PVHHFHA 264
                + HF A
Sbjct: 281 SDVLVLDHFGA 291


>UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Tax=Proteobacteria
           RepID=Q48DP3_PSE14
          Length = 304

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 81/252 (32%), Positives = 126/252 (50%), Gaps = 5/252 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L ++G DPSGGAG+QAD++   A G +    ITAL  Q+T  V     ++ ++V A
Sbjct: 46  RPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPAITALTVQDTVNVSDFRVLDREWVMA 105

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++V +D  +   K+GML   ++V+ V + L  +    +V D V+ A  G  L      
Sbjct: 106 QANAVLNDSNVAAVKLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEVG 165

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +R RLLP  ++ TPNLPEA  L + P    +    E    LL + C  +L+ GGH D+
Sbjct: 166 YAMRERLLPLSTIATPNLPEARILAELPEGTAD----ECADKLL-LFCEYLLITGGHGDE 220

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +Q  + L+ R  +        +  + HG+GCTL++ALA    +       V+ A  +   
Sbjct: 221 QQIHNRLYVRGAQTHTFICERLPGSYHGSGCTLASALAGRIAQGEELVSAVRSALDYTWR 280

Query: 243 ALAQADTLEVGH 254
            L  A+ L  G 
Sbjct: 281 TLRDAEQLGRGQ 292


>UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=15
           Tax=Actinomycetales RepID=THID_MYCLE
          Length = 279

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 92/247 (37%), Positives = 135/247 (54%), Gaps = 9/247 (3%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD++T + LG + C+ +TA+  QNT GV+  + I  + VA+Q+ +V +D+ I + K 
Sbjct: 29  GIQADMRTMTVLGVHACTAVTAVTIQNTLGVEGFHEIPAEIVASQIKAVVTDIGIQSAKT 88

Query: 79  GMLAETDIVEAVAE-RLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
           GMLA + I+ AVAE  L+      +V+D V  +  GDPLL+  A+ +LR RL P  +++T
Sbjct: 89  GMLASSSIIAAVAETWLRLELTTPLVVDPVCASMHGDPLLTGEAMDSLRDRLFPLATVVT 148

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQSPDWLFTRE--- 193
           PNL E   L+      TE +      +L A+G    L+KGGHL   ++S D L+      
Sbjct: 149 PNLDEVRLLVGIDVVDTESQ-RAAAMALHALGPQWALVKGGHLRSSDRSCDLLYGGSSAG 207

Query: 194 -GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEV 252
                F APR+ T N HG G TL+AA++          D V   K W++  L  A    +
Sbjct: 208 VAFHEFDAPRVQTGNDHGGGDTLAAAVSCALAHGYTVPDAVGFGKRWVTECLRDA--YPL 265

Query: 253 GHGIGPV 259
           G G GPV
Sbjct: 266 GRGHGPV 272


>UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosphaerula palustris
           E1-9c RepID=B8GHH9_METPE
          Length = 280

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 96/251 (38%), Positives = 136/251 (54%), Gaps = 6/251 (2%)

Query: 1   MKR---INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           M+R   + A TIAG+DP+GGAGIQADL TF+A+G +G SVITAL AQ    V S +    
Sbjct: 1   MQRSQTVCACTIAGSDPTGGAGIQADLSTFAAMGVWGLSVITALTAQTPERVDSTWVQPA 60

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
             VA QL  +  +  I   K GML +  +++ + + L       V    V+++ SG  LL
Sbjct: 61  PIVATQLKVLLEEFHIGAFKTGMLGDGSVIDTITDLLPEGVPLVVDP--VLVSSSGHRLL 118

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
           +  A+  L+ RLLP+ ++ITPNLPE   L       ++ E++  G+ LL +G  AV++KG
Sbjct: 119 AEEAIELLKERLLPRATVITPNLPETEVLSGLSPLCSDDEVIRAGKVLLDLGAAAVIIKG 178

Query: 178 GHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           GH    ++ D L T       ++ R      HGTGC  SAAL AL  R        QEAK
Sbjct: 179 GHRAGARATDLLITASTVIPLSSFRR-PYPVHGTGCCFSAALTALLARGYPLPTAAQEAK 237

Query: 238 SWLSSALAQAD 248
             +S A++   
Sbjct: 238 CLISRAVSTEP 248


>UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4Y2K1_CLAL4
          Length = 586

 Score =  256 bits (655), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 87/294 (29%), Positives = 137/294 (46%), Gaps = 35/294 (11%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           ++    LTIAG+D SGGAGI+AD+KT +A   YG + IT+L AQNT GV +V     + V
Sbjct: 35  VELPAVLTIAGSDSSGGAGIEADIKTMTAHSVYGLTCITSLTAQNTLGVSAVVDTPKEHV 94

Query: 61  AAQLDSVFSD--------VRIDTTKIGMLAETDIVEAVAERLQRYQIQNV--VLDTVMLA 110
            A L+  F D          +   K GML   D VE +A  L   + + V  V+D VM++
Sbjct: 95  KAILEKNFEDFLEGYEGAPPLKVVKTGML-TKDAVEVLASYLDYLESKKVKLVVDPVMVS 153

Query: 111 KSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDA-----PHARTEQEMLEQGRSL 165
            SG  L +   +   +  ++P+  L  PN  EA  L            T  +       L
Sbjct: 154 TSGKILTNDETMQLCQKTIIPRAYLCMPNYVEALHLWKCFGDEPIEIETVDQFKTFTVRL 213

Query: 166 L-AMGCGAVLMKGGHLDD---------------EQSPDWLF--TREGEQRFTAPRIMTKN 207
              +GC  +L+KGGH+                  +  D LF    +      +  I + N
Sbjct: 214 QEKLGCANLLVKGGHIPWLNGKKFSGKDGSGQALEIVDVLFQSDEQKVTVVRSSYIESNN 273

Query: 208 THGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           +HGTGCTL++++A+   +       V  + +++   +  +   ++GHG GP++H
Sbjct: 274 SHGTGCTLASSVASNLAKGIPLQLAVPLSVNYIHRGM-TSLKQKLGHGKGPLNH 326


>UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F301_ACIC5
          Length = 303

 Score =  256 bits (655), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 104/264 (39%), Positives = 130/264 (49%), Gaps = 8/264 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG DPS GAGI ADLK F+A   YG S +TAL  Q+T+GV     ++   +   L 
Sbjct: 37  VLTIAGFDPSSGAGITADLKVFAACQLYGVSAVTALTVQSTQGVLRSQPVDSALLGETLR 96

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ--NVVLDTVMLAKSGDPLLSPSAVA 123
            +  D+ I   KIGML   + V  VA  L+ +      VVLD V+ + SG  LL  S   
Sbjct: 97  CLQQDLPIAGVKIGMLGSGENVATVAAWLRDFSFPRERVVLDPVLRSSSGRDLLDASGQT 156

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            LR +LLPQ   ITPNL E AAL   P    EQ            G   V   GGHLD  
Sbjct: 157 LLREQLLPQTGWITPNLDELAALTGLPVTNREQMRAAAEALAATAGLR-VAATGGHLDPP 215

Query: 184 QSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
              D L T EGE Q F    + T+ THGTGC  S+AL        +    V  AK ++  
Sbjct: 216 D--DLLATPEGEAQWFPGRHLATRATHGTGCAFSSALLCRLVLGDSAEAAVAAAKQYVKE 273

Query: 243 ALAQADTLEVGHGIGPVHHFHAWW 266
           A+  A    +G G GP+HH +  +
Sbjct: 274 AMEAA--YPIGRGRGPMHHLYRAF 295


>UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41D57
          Length = 266

 Score =  256 bits (654), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 83/252 (32%), Positives = 131/252 (51%), Gaps = 15/252 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DPSGGAGI  D+KT +A G + CSVITAL AQN + V SV  IE  ++  Q+DS
Sbjct: 4   LSIAGFDPSGGAGISTDMKTMAAHGVHPCSVITALTAQNPKKVFSVQAIETSYIRQQIDS 63

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +F +  I  +K G+L   +I++ V+++++   ++ +V+D VM+A SG  L       +L+
Sbjct: 64  IFDEYPIKYSKTGLLYSKEIIQLVSKKVEELNLR-IVVDPVMVASSGGQLAKKEMANSLK 122

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL    L+TPN+ EA  L      ++ ++  E    +    C  V++ GGHLD     
Sbjct: 123 KYLLKNALLVTPNVKEAEELSGI-SIKSIEDAKEAAYKIGE--CCNVMITGGHLDGNNVI 179

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRP----------RHTNWADTVQEA 236
            +   ++         I T N HGTGC+LSAA+ A                N    ++ +
Sbjct: 180 -YNKQKDELSILKQNLIKTDNLHGTGCSLSAAICANLIILNEKDKDSKDENNLEIAIERS 238

Query: 237 KSWLSSALAQAD 248
             ++  A+ +  
Sbjct: 239 TKFIYEAVKKGR 250


>UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VXY4_MARMS
          Length = 513

 Score =  256 bits (654), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 86/265 (32%), Positives = 133/265 (50%), Gaps = 8/265 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +K      + G+D S  AG+QADL+T   L  +  +++T + AQN++ V+SV  +     
Sbjct: 3   IKPPVVWCVGGSDSSAHAGLQADLRTGQDLRCHVQTIVTCITAQNSKEVRSVEPVSLAMF 62

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQR----YQIQNVVLDTVMLAKS--GD 114
             Q  ++  DV  D  K+ +L   +I +A +  L+R    +    VV D VM A S  G+
Sbjct: 63  DEQWQTLLDDVPPDAIKVSLLPSIEIAKACSIWLRRIKADFPNVLVVFDPVMAASSESGN 122

Query: 115 PLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVL 174
            L   S  A+L   LLP + +ITPN  E   L      +   ++  Q    L+    A L
Sbjct: 123 RLQQDSVGASLLGSLLPYIDVITPNSIEFKRLTGLSDQQPAVDIQGQLAVYLSSSKCAWL 182

Query: 175 MKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQ 234
           +K GH D EQ+ DWL  ++    F   R+   NT GTGCTLS ALA+      +  D + 
Sbjct: 183 LKAGHSDSEQATDWLLDQDSIVGFAYKRLSVHNTRGTGCTLSTALASFIAHGYDLLDAMT 242

Query: 235 EAKSWLSSALAQADTLEVGHGIGPV 259
            AK++++ AL     +++G G GP+
Sbjct: 243 MAKAYITGALKTG--VQIGEGAGPL 265


>UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase n=3
           Tax=Methanosarcinaceae RepID=Q12U29_METBU
          Length = 456

 Score =  255 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 86/248 (34%), Positives = 140/248 (56%), Gaps = 10/248 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+AD+KT ++L  +G   IT++ +QNT GVQS Y + P  V+ Q+D+V +D+ +   K G
Sbjct: 31  IEADIKTLASLYVHGACAITSVTSQNTTGVQSAYELPPTVVSDQMDAVCTDMDVRWAKTG 90

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  +IV AVA+R+++Y ++ VV+D VM A++G  LL   AV+ L+  LLP    +TPN
Sbjct: 91  MLSSANIVRAVADRVKKYGLK-VVVDPVMAAEAGGDLLEKDAVSILKDELLPISYAVTPN 149

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTR--EGEQR 197
           + EA  L       T ++ +E  +++ ++G  AV++ GGH D     D ++    +    
Sbjct: 150 ISEAEILSGM-SITTREDAMEAAKAIASLGLNAVIITGGHSDG---VDLVYDSVTDEFTE 205

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
            +   I    THG+GCT SAAL +   R  +  D    AK ++ S +  +    +G G+G
Sbjct: 206 VSGKLIEGG-THGSGCTYSAALTSYLARGYSLQDAAIGAKEFVESGILLSK--NIGKGVG 262

Query: 258 PVHHFHAW 265
           PV+     
Sbjct: 263 PVNQMGYL 270


>UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F2B9_9PROT
          Length = 253

 Score =  254 bits (649), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 97/246 (39%), Positives = 127/246 (51%), Gaps = 3/246 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   LTI G+D  GGAGIQADL+ F  LG YGCS ITAL AQN   +  +  +    +
Sbjct: 6   MARPVCLTIGGSDSCGGAGIQADLRVFDRLGVYGCSAITALTAQNPLHIARIEPVSLAQL 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            A+L ++F    +   K GML + + V  V+  L      ++V+D VM++ SG  LL   
Sbjct: 66  DAELHALFDYYDVAVVKTGMLLDAEHVAVVSGLLAELHHGSLVVDPVMISSSGSVLLDQG 125

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            VA LR  LLPQ +LITPNL EA ALL  P        +E  ++L       VL+KGGH 
Sbjct: 126 GVAALRGALLPQAALITPNLDEADALLGQPSGYAADSPVEAVKALREALGCPVLLKGGHA 185

Query: 181 DDEQSPDWLFT-REGEQRFTAPRI--MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           D +   D L    EG  RFT  R        HGTGC L++A+AA           V+ A 
Sbjct: 186 DGDMLLDLLCDEEEGIHRFTHIRQCWSAGEGHGTGCRLASAVAAGLANQMPLVPAVEAAI 245

Query: 238 SWLSSA 243
           ++L   
Sbjct: 246 AFLQEC 251


>UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-phosphate
           pyrophosphorylase n=3 Tax=Alteromonadales
           RepID=Q3IFN5_PSEHT
          Length = 508

 Score =  253 bits (647), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 83/252 (32%), Positives = 129/252 (51%), Gaps = 14/252 (5%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K   + G +GC+ ITAL AQN+ GV+++  +  D + +QL ++  D++    KI
Sbjct: 18  GIQADIKAMQSFGVHGCTAITALTAQNSLGVEAINAVSTDIIESQLLALEKDMKAKVIKI 77

Query: 79  GMLAETDIVEAVAERLQRYQ-----IQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQV 133
           GMLA    ++ ++E +  Y+        +V D V +A SGD L     V+ ++  LLP V
Sbjct: 78  GMLANVQQIQLISEHISHYKAKWPVPPVIVYDPVAIASSGDLLTEEDTVSAIKECLLPLV 137

Query: 134 SLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQSPDWLFT 191
            +ITPN  E   LL   +      + E    LL+ G  AV++KGGH D       D+   
Sbjct: 138 DVITPNTHETQ-LLTGVYLIGPAAIKEAANKLLSWGAKAVVIKGGHWDYPSGYCIDYCIN 196

Query: 192 ----REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
               +  E      +I T + HGTGC++++ +AA   +     D    AK++++  L  A
Sbjct: 197 NFTQKGEEYWLGNEKIQTPHNHGTGCSMASVIAACLAKDYPLKDAFILAKAYINQGLKVA 256

Query: 248 DTLEVGHGIGPV 259
                G GIGPV
Sbjct: 257 VRY--GEGIGPV 266


>UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolobaceae
           RepID=A4YD59_METS5
          Length = 403

 Score =  253 bits (646), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 105/265 (39%), Positives = 147/265 (55%), Gaps = 7/265 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+R  A+TIAG+D  GGAG+QADLKTF++LG +G SVIT L AQNT  V  V  + P+FV
Sbjct: 2   MQRPIAMTIAGSDSGGGAGVQADLKTFTSLGVFGVSVITGLTAQNTARVTKVLEVPPEFV 61

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q D++  D ++   K GMLA + IV+AV  +L +Y I N+VLD VM++KSG PL++  
Sbjct: 62  ESQFDTIMEDFQVKYAKTGMLASSRIVDAVERKLTQYGI-NLVLDPVMISKSGYPLVTEE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            V  +  RL  +  +ITPN  EA  L      RT  ++      L       V++KGG  
Sbjct: 121 VVRDIV-RLARKSLIITPNKYEAERLTGF-RIRTRDDLRNTALHLYKSLGVNVVVKGGKA 178

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D+      E       I T N HG+G   SA++ A   +  N  D ++EAK  +
Sbjct: 179 IG--GYDFAVVDGDEIELRGELINTDNLHGSGDVFSASITAFLSKGLNLRDALREAKKVV 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           S A+    +L +GHG GPV  F + 
Sbjct: 237 SEAIKF--SLAIGHGNGPVDPFSSV 259


>UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma phagocytophilum HZ
           RepID=Q2GJ96_ANAPZ
          Length = 265

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 94/264 (35%), Positives = 146/264 (55%), Gaps = 6/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M + N L+IAG+D  GGAGIQAD+KT + LG Y  + ITA+ AQNT+ V+ V+ + P+ V
Sbjct: 1   MYKGNVLSIAGSDSGGGAGIQADIKTITMLGCYAATCITAITAQNTQEVRGVWELAPEVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL++V  D+++D  KIGML    ++  VAE L       V+LD VM++ SG  L  P 
Sbjct: 61  KGQLEAVLDDLKVDAIKIGMLP-VGLIGVVAESLPC--EIPVILDPVMVSTSGFELTDPM 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGH 179
                   L    +L+TPN+ E  AL    + RT +EM+  G  ++  +G  AVL+KG  
Sbjct: 118 GYTESIRPLAQNAALVTPNIKETEALSGMKNIRTREEMVTAGNKIIQFLGIKAVLVKGCI 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            ++E+  + +   +G+  F          HGTGCTL++A+A    R  +  ++ + A  +
Sbjct: 178 WEEEEFVESVLIYDGKTVFFRNERAPGELHGTGCTLTSAIACFIARGLSLEESTRLAFDY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +S  +  A    VG G+ P+ H +
Sbjct: 238 VSCTIRNAPI--VGQGLRPLFHNY 259


>UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), ThiD n=2
           Tax=Methanobrevibacter smithii RepID=A5UJW6_METS3
          Length = 246

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 83/245 (33%), Positives = 127/245 (51%), Gaps = 7/245 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +  ++IAG DPSGGAGI AD+KTF ALG YG  ++TAL AQN + + S+  IE D+V  Q
Sbjct: 1   MIVMSIAGVDPSGGAGILADIKTFQALGVYGTGIVTALTAQNPQMMYSLKAIETDYVEEQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V     ++  K GML   DI++ V+++++ Y ++ VV D VM+A SG  L       
Sbjct: 61  IDAVLDSYNVEYIKTGMLYSKDIIKTVSKKIREYNLKAVV-DPVMVATSGGELAKDDLSQ 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP+  L TPN+ EA  L     A  ++E  E     L   C  + + GGHL+  
Sbjct: 120 NLLKYLLPKAILTTPNVSEAEKLTGIKIA--DEEKAEIACEKLGKICNNI-ITGGHLNG- 175

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              +          F    + T N HG+GC  SAA+ +   +  +   ++ +A  +   +
Sbjct: 176 --TNITCIDGKISTFKQELLKTDNVHGSGCNFSAAIVSYLSQKNDLKTSILKASEYTYES 233

Query: 244 LAQAD 248
           +    
Sbjct: 234 IKNGK 238


>UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax=Enterococcus
           faecium RepID=C2HB32_ENTFC
          Length = 275

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 79/267 (29%), Positives = 136/267 (50%), Gaps = 11/267 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKRI  LTI G+DP  G GIQ DLKTF   G +G S +T++   +T G   +  I  + +
Sbjct: 6   MKRI--LTIGGSDPFAGGGIQTDLKTFEDFGLFGLSALTSIGVLDTNGRFILESIPSELL 63

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL S+     +D  KIG+L  ++ +  V + ++  Q   ++LD V+  K  + +++  
Sbjct: 64  ERQLASIDQMTSLDGIKIGLLNSSEAIMVVRDFIKAKQNIPIILDPVLAFKETETVINQW 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-H 179
            ++ L   L P V++ITPNL EAA L       +  EM+   + L A G   +++KGG  
Sbjct: 124 YISQLIEELFPLVTMITPNLAEAALLSGQALPSSLIEMIHLAKELTASGAKKIVIKGGTR 183

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +  EQ+ D L++ +  + F+  ++ T   +G GC  S+A+ A     T+ +  V E+K +
Sbjct: 184 MAGEQAVDLLYSVDHHEVFSQKKVDTPTVNGAGCAFSSAITANLVLGTDVSKAVAESKKF 243

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++  ++    +          H  + W
Sbjct: 244 VAHCISNGVLMN--------DHTGSVW 262


>UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3 Tax=root
           RepID=Q1EI25_9ZZZZ
          Length = 284

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 103/254 (40%), Positives = 146/254 (57%), Gaps = 11/254 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT +ALG Y  + +TAL AQNTRGV S++ +  DFVA Q+  V SD+  D  K+G
Sbjct: 27  IQADIKTVTALGGYAMTAVTALTAQNTRGVFSIHDVPADFVAEQMRVVLSDIGADCVKVG 86

Query: 80  MLAETDIVEAVAERLQRY-------QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQ 132
           ML    ++EAV + L+         +   +V+D VM+AK G+ LL+P A+A+L++R++P 
Sbjct: 87  MLHTPGVIEAVCDVLEAEAEAAAGGRRVPIVVDPVMVAKGGESLLAPDAMASLKARMIPL 146

Query: 133 VSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWL-FT 191
             ++ PN+ EA AL          +     R L A G  AVL+KGGHL  E   D L   
Sbjct: 147 AHVLMPNVAEAEALTGLT-VGGPDDAGTVARKLAAAGAAAVLLKGGHLPGETVIDILAVD 205

Query: 192 REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLE 251
            E  + F +PRI T +THGTGCTL++A A    +     D V  A+ ++  A+  A  L 
Sbjct: 206 GEIVEVFESPRIDTPHTHGTGCTLASATATGLAQGMAVRDAVARARRYVHEAILTAPGL- 264

Query: 252 VGHGIGPVHHFHAW 265
            GHG GP++H H  
Sbjct: 265 -GHGHGPLNHAHTV 277


>UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolobaceae
           RepID=C3NMB3_SULIN
          Length = 456

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 75/260 (28%), Positives = 133/260 (51%), Gaps = 7/260 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +   +T+AG D   GAG + DL+ F  LG +G   ITA+ AQ+T+G++ +  +  +F+
Sbjct: 13  MIKPVGMTVAGLDTGNGAGGETDLRVFEVLGIHGVFAITAITAQSTKGIKDINVVSSEFL 72

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++++  D  ++  K+GM+   +  + V E L       +V+D V+ AK G PL+   
Sbjct: 73  KKQIETLLDDFNVEAVKMGMIYTKEQFQVVNELLHD---SFLVVDPVLYAKDGTPLIKD- 128

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            V   +  +LP   +ITPN+ EA+A+      +    ++   +         V++KGGH 
Sbjct: 129 -VEDYKKIILPIAKVITPNIIEASAISSIKVEKESDVVIACKKIRETYNIAHVIIKGGHS 187

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             + S D++   EG  +    RI  K+THGTG   + A  A   +  +     ++A+ ++
Sbjct: 188 KGDFSFDYMCNEEGVYKIGYHRIQAKDTHGTGSVFATAFTAEYIKTKDVKLAFRKARDFV 247

Query: 241 SSALAQADTLEVGHGIGPVH 260
            S +     L +G G+GPV+
Sbjct: 248 QSPIEYG--LNIGKGVGPVN 265


>UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax=Perkinsus marinus
           ATCC 50983 RepID=C5LCI6_9ALVE
          Length = 504

 Score =  251 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 87/256 (33%), Positives = 137/256 (53%), Gaps = 13/256 (5%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           QADLKT  ALG Y  S +T++ AQNT+GVQ +  +  D  AAQ++SV SD  +   K+G+
Sbjct: 248 QADLKTLEALGVYSTSALTSITAQNTKGVQQIQVVNEDIFAAQMNSVTSDFEVSVVKLGL 307

Query: 81  LAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL----SPSAVATLRSRLLPQVSLI 136
           +     +E V E+L       +V+D V++A SGD L+    +   +A  + R+ P+ ++I
Sbjct: 308 VPTARQLEIVGEKLAEL---PMVVDPVLVATSGDDLVAQKNAEDVLAMYKERIFPRATII 364

Query: 137 TPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ--SPDWLFT--R 192
           TPN+ EA  +L         E     ++L   G   VL+KGGH + +     D L+   +
Sbjct: 365 TPNVVEAERILGRKEISGVYEARAAAQALAQYGSKYVLLKGGHDETDPKACRDVLYDREK 424

Query: 193 EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEV 252
           +    FT  RI T NTHGTGCTL++A++A   R       V+ A  +L   + ++  + +
Sbjct: 425 DEFYEFTNRRIATINTHGTGCTLASAISAFMARGYPVPVAVERAIGYLHEVIVRSCGVPL 484

Query: 253 GHGIG-PVHH-FHAWW 266
           G G   P+ H  ++ W
Sbjct: 485 GQGTNRPLVHSANSVW 500


>UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JTI6_9GAMM
          Length = 288

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 81/252 (32%), Positives = 124/252 (49%), Gaps = 6/252 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L ++G DPSGGAGI AD++  S+ G   C  ITA+  QN+R V SV+ ++P+ +  Q
Sbjct: 5   PVVLCLSGFDPSGGAGIGADIEALSSQGCQACGAITAMTVQNSRDVISVHPVDPNVIIQQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLA-KSGDPLLSPSAV 122
             +V  D+ +   KIG++   ++  A+   L  Y    VVLD V+ +  SG  L     V
Sbjct: 65  ARAVLEDMPVAVIKIGLVGSVEVAAAIHSVLSDYPDIPVVLDPVLASGGSGRALADDGLV 124

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             + + L+PQ +LITPNL EA  L+     R           L+  G  +VL+ GG    
Sbjct: 125 EAILNLLVPQATLITPNLREAHTLIAGADTR-----QAAAIGLMEAGAQSVLLTGGDEPG 179

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +   + LF  +   R      +    HG+GCTL+A+ A L        + V+ A+ +  +
Sbjct: 180 DDVLNTLFAEQRWVRDYHWPRLPHQYHGSGCTLAASAAGLIAHGILLEEAVEGAQEYTWN 239

Query: 243 ALAQADTLEVGH 254
           AL  A  L +G 
Sbjct: 240 ALYNAVRLGMGQ 251


>UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosaccharomyces
           japonicus yFS275 RepID=B6K6F0_SCHJY
          Length = 376

 Score =  250 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 78/265 (29%), Positives = 130/265 (49%), Gaps = 21/265 (7%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   LT+AG+D SGGAG+QADLK   A   YG SV+T + +QN+ G+  V+ I    +  
Sbjct: 64  RPVCLTVAGSDSSGGAGLQADLKAILAHKVYGMSVVTCITSQNSTGLHDVFPIPAPLIEQ 123

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++  +DV     KIGML++ D ++AV   L RY+++NVV+D+V++   G+ +    A+
Sbjct: 124 QFNACLADVECHAVKIGMLSDVDSIQAVVRALDRYKVKNVVMDSVIVTNRGNVMCQKRAL 183

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQG------RSLLAMGCGAVLMK 176
            +L   L+P+V +   N+ EA  L+     R+   M   G        L  +G   V++K
Sbjct: 184 RSLIRDLIPRVLVFGSNIMEACLLVKGATGRSFTSMRSFGDICKLLEELWKLGPKYVILK 243

Query: 177 GGHLDDEQ---------------SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
           G H+  +                + D ++          P +   N  GT C+L+A++A+
Sbjct: 244 GHHVAFDNRLRIVENASQRQPLWTIDTVYDGSQIYIVHKPYVSNYNVRGTSCSLTASVAS 303

Query: 222 LRPRHTNWADTVQEAKSWLSSALAQ 246
                      +++A S +  AL  
Sbjct: 304 NLALGKPPLIAIRDAISMVEIALEH 328


>UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii
           RepID=A5DP35_PICGU
          Length = 559

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 90/282 (31%), Positives = 145/282 (51%), Gaps = 28/282 (9%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L +AG+D SGGAGI+ADLKT SA   YG + I A+  QNT+GV+S+       +   
Sbjct: 19  PVVLVVAGSDSSGGAGIEADLKTLSAHKVYGATCIAAITVQNTQGVRSIVETSGATIRGI 78

Query: 64  LDSVFSDV---------RIDTTKIGMLAETDIVEA--VAERLQRYQIQNVVLDTVMLAKS 112
           LD+V  D           +   K GML    + E   + + +    I+ +V+D VM++ S
Sbjct: 79  LDAVMDDFGRKDVAAKSPLRAIKTGMLTPAALEELANIRDEVDSLGIK-LVVDPVMVSTS 137

Query: 113 GDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM--LEQGRSLL---- 166
           G  L+S  ++A+   RL+    L+TPN  EA  L  A + +T+  +  +E+G+  +    
Sbjct: 138 GARLMSEDSMASYL-RLISGSFLVTPNYLEALELAKAVNLKTDGSINSIEEGKRFVLELR 196

Query: 167 -AMGCGAVLMKGGHLDD------EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAAL 219
            A+ C  +L+KGGH+         +  D+L        F +  I TK+ HG+GCTL++AL
Sbjct: 197 NALKCDNLLVKGGHIPGFSGESERRIYDFLNQNGKLTVFESHYIDTKDNHGSGCTLASAL 256

Query: 220 AALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           +A    +    + V  A  ++  A++  + L  G G GP++H
Sbjct: 257 SAHIALNRPVEEAVPLALDYIHHAMSNFEKL--GRGNGPLNH 296


>UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) n=1
           Tax=Thalassiosira pseudonana RepID=B8C466_THAPS
          Length = 265

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 85/259 (32%), Positives = 131/259 (50%), Gaps = 25/259 (9%)

Query: 20  IQADLKTFSALG---AYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTT 76
           IQADLK    L     +GCS IT L AQN+ GV SV+     F+  QL+ +  D+     
Sbjct: 13  IQADLKAIHTLSNGACHGCSAITCLTAQNSCGVTSVHSPPVAFLREQLNVLEGDLYPKAV 72

Query: 77  KIGMLAETDIVEAVAERLQRYQIQN---------VVLDTVMLAKSGDPLLSPSAVATLRS 127
           K+GML   ++ E V   L++ + ++         VV+D VM++ SG  L+  +A   +  
Sbjct: 73  KVGMLGSGELAEEVGGWLRQLKEKHSGDGGVMPLVVVDPVMISTSGHKLVDDTAKKAMIE 132

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--LDDEQS 185
           ++ P   L+TPN  EA  LL      T  ++ E    +LAMG  AVL+KGGH  ++ ++ 
Sbjct: 133 KVFPFADLVTPNKFEAEELLGRKLL-TPSDVKEGAAEILAMGAKAVLIKGGHSLMETQRV 191

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN-----WADTVQEAKSWL 240
            D    +E      + R  T +THGTGCTLS+A+A               D    AK+++
Sbjct: 192 VD---EKEDGIWIRSERYETSHTHGTGCTLSSAIATAWAMGQPLSAMHLVDACCIAKAYV 248

Query: 241 SSALAQADTLEVGHGIGPV 259
           +  +  +  +++G G GPV
Sbjct: 249 NDGI--SKGVQLGKGPGPV 265


>UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphilium cryptum JF-5
           RepID=A5FWQ5_ACICJ
          Length = 272

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 92/245 (37%), Positives = 138/245 (56%), Gaps = 4/245 (1%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           +AD+KT +ALG Y  + ITA+ AQ+T G+ ++  + PD VA  +  V +D+ +D  K+GM
Sbjct: 21  EADVKTITALGGYAMTAITAVTAQDTSGIAAIAPVPPDLVARSIRMVVADLGVDAIKLGM 80

Query: 81  LAETDIVEAVAERLQRYQIQNVV-LDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           L      E VA  +        + LD V+ + SG  L    A+A +R RLLP+ +L+TPN
Sbjct: 81  LGSAGTAEEVALAIAAAAPAAPLVLDPVLASTSGTALAGEGALAIIRDRLLPRATLVTPN 140

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
             EAA L       + ++ +  GR+L  +G  AVL+KGGH D +   D L   +    F 
Sbjct: 141 RDEAATLAGLA-IDSHEDAIRAGRALCRLGARAVLLKGGHFDGDPVIDRLIAGDDVVTFA 199

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
            PRI T++THGTGCTL++A+A    R  +    ++ A+++L +AL  A  L  G G GP+
Sbjct: 200 HPRIATRHTHGTGCTLASAIACGLARGLDLRAAIEAAEAFLHAALRAAPGL--GRGHGPL 257

Query: 260 HHFHA 264
            H  A
Sbjct: 258 GHARA 262


>UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcanivorax
           RepID=Q0VSP4_ALCBS
          Length = 253

 Score =  247 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 83/254 (32%), Positives = 126/254 (49%), Gaps = 7/254 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           + N L IAG DPSGGAGI AD++   ALG +  ++IT L  QN++ V+     E D +  
Sbjct: 2   KPNILVIAGHDPSGGAGIHADIEAIQALGGFASTLITGLTVQNSQNVRGFRLTEIDLLQQ 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q D++  D+     KIGM     IV+ + + L+R     V+LD V+ A++G  L   S  
Sbjct: 62  QADALLDDMDYQAIKIGMTGSIAIVDFITQLLKRLPNVPVILDPVLAAEAGGSLAQESLA 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +   L P   ++TPNLPEA AL               G+ L+     A L+ G H D 
Sbjct: 122 EVMLDTLAPLCDVMTPNLPEAQALSGQQSVSG------CGQVLVQRSGCATLITGTHDDT 175

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +Q  + LFT  GE+++   R+     HG+GCTL++++A LR    +    V   ++ +  
Sbjct: 176 DQVVNHLFTPSGEEQWHWDRL-PHRYHGSGCTLASSIACLRGHGQSLHSAVANGQAHVDK 234

Query: 243 ALAQADTLEVGHGI 256
            L  A     G  +
Sbjct: 235 FLRNAFQPGQGQYV 248


>UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonella
           RepID=A9IRG3_BART1
          Length = 259

 Score =  247 bits (631), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 77/241 (31%), Positives = 124/241 (51%), Gaps = 1/241 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
            + L +AGTDP+GGAGI  D++T +         IT +  Q+   V  +  +    +AAQ
Sbjct: 12  PSILIVAGTDPTGGAGIVRDIETAAYFHIKANLAITCVNVQDDHHVAEIVPMNEKLIAAQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +        I   KIGM     I+ A+   L+ Y    V+LD V++A SG  L +   + 
Sbjct: 72  MRIALEANPIRAIKIGMTGNQAIIAAICRVLEDYPHIPVILDPVLVASSGGKLTTEKIIE 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            + ++LLP V+L+TPN  E A L   P A   +E ++Q + LL++G  ++L+KGGH +  
Sbjct: 132 IMINQLLPYVTLLTPNRDELALLSQTPLASHHEETIQQAKKLLSLGARSILVKGGHAEGP 191

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D    +      +APR+      GTGC LS+A+AA    +      V++AK++  + 
Sbjct: 192 LAIDSFIDKMEVINISAPRLK-GTMRGTGCILSSAIAAHLALNEPLISAVKKAKAYTHTL 250

Query: 244 L 244
           L
Sbjct: 251 L 251


>UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus anthracis str.
           A0193 RepID=B0Q8A3_BACAN
          Length = 223

 Score =  247 bits (631), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 76/198 (38%), Positives = 113/198 (57%), Gaps = 5/198 (2%)

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + +D+  D  KIGML  ++I++ VAE + ++   N+VLD VM+AK G  LL   AV  L+
Sbjct: 20  IQADLTPDAVKIGMLFSSEIIQIVAEYINKFGWNNIVLDPVMIAKGGASLLQQEAVQALK 79

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQ 184
             LLP  ++ITPN+PEA  L         ++  E  + L  +G   VLMKGGH +    +
Sbjct: 80  EYLLPVATVITPNVPEAEVLTGL-EIHNIEDSKEAAKVLHELGAKYVLMKGGHAEYQGNE 138

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             D LF  E    F + RI +K THG+GCT ++A+ A   +  +  + VQEAK ++S A+
Sbjct: 139 VIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSMEEAVQEAKRFISIAI 198

Query: 245 AQADTLEVGHGIGPVHHF 262
              + L +G G GP +HF
Sbjct: 199 E--EPLHIGSGHGPTNHF 214


>UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZRE6_9GAMM
          Length = 262

 Score =  246 bits (630), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 91/254 (35%), Positives = 138/254 (54%), Gaps = 10/254 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+DP GGAG+QADL TF+ LG +G + +TA+  Q+TR V     + P+ + AQ
Sbjct: 5   PIALTIAGSDPGGGAGLQADLTTFTRLGVHGATAVTAITVQDTRNVVDFTVLPPEQLRAQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           ++   +D+ +   KI ML   + V  ++  L  +    VVLD VM+A  G  L + + V 
Sbjct: 65  IEVTLADLEVAAIKISMLGSVENVTVISALLGAHPHIPVVLDPVMVAGGGGALATEAVVD 124

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--LD 181
             R  LLP+ +LITPN PEAA L  +      ++  + G  L  +G   VL+ GGH   +
Sbjct: 125 ATREALLPRATLITPNGPEAARLARS------EDPAQWGHQLRQLGARNVLVTGGHEGTE 178

Query: 182 DEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            +   + L+  +   R F  PR      HG+GCTL+AA+AA   R  +    V EA++++
Sbjct: 179 QDPIINRLYREDDHVRPFELPR-HPAGFHGSGCTLAAAIAAFLARGRDIEPAVIEAQAFM 237

Query: 241 SSALAQADTLEVGH 254
           + A+A+      G 
Sbjct: 238 NDAIARGYAPGRGQ 251


>UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
           n=1 Tax=Schizosaccharomyces pombe RepID=THI21_SCHPO
          Length = 506

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 81/280 (28%), Positives = 134/280 (47%), Gaps = 21/280 (7%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             +T+AG+D SGGAG+QADLK F+A   YG S +TA+ +QNT GV  V+ I   +V  Q+
Sbjct: 4   TCITVAGSDCSGGAGVQADLKVFTAHSVYGMSAVTAITSQNTIGVNGVHLIPASYVEQQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +   DV  +  K GML    I++ + E + R++I+ VV+D ++  + G  L+ P  +  
Sbjct: 64  SACLLDVHCEVMKTGMLFNQQILKVIVESIDRFKIKKVVVDPLIATRKGALLVMPDYLEL 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAP-----HARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
               L+P+  ++ PN+ EA  +L             +++   G+ L+  GC  V+++   
Sbjct: 124 FVKELIPRAEVLIPNIAEALIILKHMTNEFVEIHHLEDVKAVGKKLIKAGCKNVVIRCDD 183

Query: 180 L----------DDEQSPDW----LFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR 225
           +          +    P W    L T EGE       + +K   GT C LS+A+A+    
Sbjct: 184 IPFASDFFCSRETNMPPTWYLYVLCTSEGEVLLPQKWLASKTARGTSCALSSAVASNLAI 243

Query: 226 HTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
             +     Q A S+   AL    +  +G G   + +  A 
Sbjct: 244 GLDLVTATQNAVSYTQRALEM--SFHLGRGANSLDYASAL 281


>UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivallis vadensis ATCC
           BAA-548 RepID=D1N338_9BACT
          Length = 281

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 87/233 (37%), Positives = 131/233 (56%), Gaps = 4/233 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+ADL+TF+A G YGC+ +TA+ +QN   V+ +  I  + V  Q+++V   + +   K G
Sbjct: 28  IEADLRTFNAYGVYGCAALTAVTSQNPAEVRRIDAIPAEGVRCQIETVLDRIPVRAVKSG 87

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    IVEAVAE +++ ++  +V D VM++ SG  LL   AVA +R  LLP  + ITPN
Sbjct: 88  MLFNAAIVEAVAEVVKQRRLM-LVCDPVMVSTSGAALLEKEAVAKVRELLLPVAAWITPN 146

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGE-QRF 198
           LPEA  LL     +T  +  +  +        AVL+K GH    +       REG+    
Sbjct: 147 LPEAELLLG-RELKTADQFADAAKECFDRWGAAVLLKTGHALSGKFVTDFVCREGKIYTL 205

Query: 199 TAPRIM-TKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTL 250
           +APR+     +HGTGCTLS+ALAA       W   V EAK++++ +L ++  +
Sbjct: 206 SAPRVPENGASHGTGCTLSSALAAGFALEMPWKQAVCEAKAFVTGSLRESVPI 258


>UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=Lactobacillus sakei
           subsp. sakei 23K RepID=Q38VX7_LACSS
          Length = 264

 Score =  246 bits (628), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 80/253 (31%), Positives = 125/253 (49%), Gaps = 1/253 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D  GG G+QADLKTF A G +G S +T L          +  IE + V AQ+
Sbjct: 3   NILTIAGSDTLGGGGLQADLKTFEAFGHFGVSAVTCLATVMPDQTFQIQNIETETVLAQI 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++   V + T KIG++ +   +E +   LQ+     ++ D V+  K     L    + +
Sbjct: 63  EAILHYVPLTTIKIGLINDATTLEKIGHLLQKQPHLQIITDPVLAFKETTDKLQQHYLDS 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L+  LLPQ  ++TPNL EA  L   P  +T  E+ +    + ++G   V++KGG     +
Sbjct: 123 LKDVLLPQSLVVTPNLVEAQLLSGLPQIQTRAELEQAATIIQSLGPQHVVIKGGQRFPGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L +       +APR+ +   +G GCTLSAA+ A           V+ AK ++   
Sbjct: 183 DAIDLLHSGTTNHYLSAPRLTSATRNGAGCTLSAAITAEIASGHAVYPAVKAAKQFVYHG 242

Query: 244 LAQADTLEVGHGI 256
           +     L  G G 
Sbjct: 243 IQNGIQLRHGFGN 255


>UniRef50_C5A6B1 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Thermococcus
           RepID=C5A6B1_THEGJ
          Length = 428

 Score =  246 bits (628), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 72/246 (29%), Positives = 123/246 (50%), Gaps = 13/246 (5%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +  L +AG D  GGAG++AD++T SALG +   V+TA+  QN   V+  + +  + V   
Sbjct: 2   MAVLIVAGLDTGGGAGLKADIETVSALGEHPLPVLTAVTYQNPFEVRGYHTLPSEVVREG 61

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V     +   KIGML   ++   V E    +     V D V+ + +   L+  +   
Sbjct: 62  IRAVKDGFEVKAVKIGMLGSGEVARVVREETAGFPR---VFDPVIASSTEKKLIDDT--E 116

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLDD 182
           +L++ L+P  S++TPN+ EA AL      R+ ++M +   +L+   G  A ++KGGHL+ 
Sbjct: 117 SLKT-LVPG-SIVTPNVYEAEALASI-EIRSVEDMKKAATALVEEFGAEAAVVKGGHLN- 172

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
               D L+ R     F   ++    THGTGC  S+ALA    +       V+ AK ++  
Sbjct: 173 --FTDVLYWRGEFYEFRGEKVEGF-THGTGCAFSSALATFLAKGFELPKAVERAKRFVEG 229

Query: 243 ALAQAD 248
           ++  + 
Sbjct: 230 SIRFSK 235


>UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta proteobacterium MLMS-1
           RepID=Q1NV70_9DELT
          Length = 288

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 101/275 (36%), Positives = 141/275 (51%), Gaps = 21/275 (7%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+DP+GGAGIQADLKT +ALG YG + IT +  QN++GV+    +E   V  Q+ +
Sbjct: 10  LSIAGSDPAGGAGIQADLKTCTALGVYGAAAITCVTVQNSQGVRYFEPLEQQLVYDQIRA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+ I   KIGML    + +AVA  L  +    +V D V+ A  G  LL  +A+  L 
Sbjct: 70  VLVDLPISHIKIGMLGSAQVADAVAAALHDF-TGVIVYDPVLKAGDGHTLLPATALQRLA 128

Query: 127 SRLLPQVSLITPNLPEAAALL-----------DAPHARTEQEMLEQGRSLLAMGC--GAV 173
           + LL ++++ITPNLPE A L              P        L     LL       AV
Sbjct: 129 ADLLSKITVITPNLPELATLDRLLPQPPGQAPSLPAGIGADSPLTAAARLLQRFPRLQAV 188

Query: 174 LMKGGHLDDE--QSPDWLFTREG-----EQRFTAPRIMTKNTHGTGCTLSAALAALRPRH 226
            + GGH + E  +  DWL TR         R   PR+ + N HGTGCT + ALAA     
Sbjct: 189 ALTGGHAEPEYDELTDWLLTRGEGQQLKVTRVEHPRLKSGNLHGTGCTFATALAACHLLS 248

Query: 227 TNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
            ++   ++ A  + S+A+     L +G G GP+ H
Sbjct: 249 GDYQRAMRRAVDFTSAAIKAGAGLSMGGGNGPLAH 283


>UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Mannheimia haemolytica
           RepID=A7JV63_PASHA
          Length = 509

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 84/248 (33%), Positives = 125/248 (50%), Gaps = 8/248 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
             T+AG+D   GAG+Q DL TF      GCSV+T++ AQ+  GV  V  ++      Q +
Sbjct: 14  IWTVAGSDSCAGAGLQTDLHTFHDFNLVGCSVVTSVTAQHPHGVLCVTPVDDHTFRQQFE 73

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-----VVLDTVMLAKSGDPLLSPS 120
           ++      +  KIG+L     VE + E +Q+ + ++     VV D V +A SG  L    
Sbjct: 74  ALLVQGYPNAIKIGLLCSQAQVEILCEYIQKIRAESSHYCYVVYDPVAVASSGQALSDSI 133

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  ++ +L P V LITPN  E A L D    +T  ++      L A G  AVL KGGH 
Sbjct: 134 LLQIVQQKLYPLVDLITPNGTELALLSD-TEIQTFGDVKTASHKLFAQGIKAVLAKGGHF 192

Query: 181 D--DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           +   E   D+L T      F+  R  + NTHGTGCT ++A+ A+     + AD V  A +
Sbjct: 193 EWLGETVRDYLLTANEIYAFSHARQQSVNTHGTGCTYASAVGAMLATGFDLADAVTVATA 252

Query: 239 WLSSALAQ 246
           +L   L++
Sbjct: 253 YLQKGLSE 260


>UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_SYNE7
          Length = 263

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 102/267 (38%), Positives = 145/267 (54%), Gaps = 5/267 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQADL+TF+    +G   IT + AQNT GV  V  I P  V
Sbjct: 1   MAVPIALTIAGSDSGGGAGIQADLRTFAFHQVHGTCAITCVTAQNTLGVTRVDAIAPAGV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AAQLD+V SD+     K GML   +I+E VA  +    I  ++ D VM++++G  L+  +
Sbjct: 61  AAQLDAVLSDLPPQALKTGMLLNAEIMEVVAGTIAPLFIPRII-DPVMVSRTGAVLIDQA 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+A LR  LLP  +++TPN  EA  L      +   ++    R +  +G  AVL+KGG  
Sbjct: 120 AIAVLRDHLLPLATVLTPNRYEAQLLAGM-DIQDAADLDRAARIIRDLGPQAVLIKGGAA 178

Query: 181 DDE-QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             +    DW +  +         I T +THG+GCTL+AA+AA            Q AK +
Sbjct: 179 TGDWHGVDWWWDGQQSHILKTEAIATPHTHGSGCTLAAAIAANAALGLEILAAAQAAKHY 238

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++ AL    +L +G G GP+ HF+  +
Sbjct: 239 VTKALRH--SLAIGQGQGPLGHFYPLF 263


>UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax=Filobasidiella
           neoformans RepID=Q5KEL1_CRYNE
          Length = 561

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 99/297 (33%), Positives = 138/297 (46%), Gaps = 57/297 (19%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  A G YG SV+T L AQNT GVQ+V+ +  DFV  QL SV SD      K+G
Sbjct: 31  IQADLKTIEAFGCYGSSVLTGLTAQNTLGVQAVHVVPTDFVIQQLQSVISDELPKAIKLG 90

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML     + A+A  + +     +VLD VM++ SG  LL   A+  L   L P V  +TPN
Sbjct: 91  MLTCASTIRALAREVSKLNTT-IVLDPVMISTSGHTLLPDDAMEALYE-LYPHVDYLTPN 148

Query: 140 LPEAAALLD-APHARTEQEMLEQGRSLLA-MGCGAVLMKGGHL----------------- 180
           +PEA  L   +   +   +M+E  +         +VL+KGGH                  
Sbjct: 149 IPEAKNLSGWSHEIKNLDDMIELAKKTNETTKSPSVLLKGGHAIVSREEVLKYAGKYELI 208

Query: 181 -----DDEQSPD---------------------WLFTREGEQR--FTAPRIMTKNTHGTG 212
                D++ + +                      L  +EGE    F   ++ +++THGTG
Sbjct: 209 WEEGDDEDDAVEVYNEYKESLDINIKTQKDLVVDLLIKEGEIIAMFVGKKVDSQSTHGTG 268

Query: 213 CTLSAALAALRPRHTNWADT------VQEAKSWLSSALAQADTLEVGHGIGPVHHFH 263
           CTLSAA+A      +  AD        + A  +  SA+A A     GHG GP++H H
Sbjct: 269 CTLSAAIACSIAVSSEVADAKSLISVFKRAIGYTQSAIATA--FPFGHGHGPLNHGH 323


>UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=17
           Tax=Actinomycetales RepID=THID_MYCBO
          Length = 265

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 102/267 (38%), Positives = 149/267 (55%), Gaps = 5/267 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L+IAG+D  GGAGIQAD++T + LG + C  +TA+  QNT GV+ ++ +  D V
Sbjct: 1   MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSP 119
           A Q+++V +D+ +   K GMLA + IV  VA   +R ++   +V+D V  +  GDPLL+P
Sbjct: 61  AGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           SA+ +LR +L P  +L+TPNL EA  L+D      E +     ++L A+G   VL+KGGH
Sbjct: 121 SALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQ-RAAAKALHALGPQWVLVKGGH 179

Query: 180 L-DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L   + S D L+      +F A R+ T + HG G TL+ A+AA         D V   K 
Sbjct: 180 LRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKR 239

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           W++  L  A    +G G GPV      
Sbjct: 240 WVTECLRAA--YPLGRGHGPVSPLFRL 264


>UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptococcaceae
           RepID=A2RIH2_LACLM
          Length = 262

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 73/253 (28%), Positives = 128/253 (50%), Gaps = 8/253 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D   G G+QADL TF+A G YG   +T++V         V+ ++ +    +
Sbjct: 9   KKILTIAGSDILSGGGMQADLATFAANGLYGFCALTSIVTVKEDKFF-VHPVDEEIFQEE 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ---NVVLDTVMLAKSGDPLLSPS 120
           L+S+  D+     KIG+L    I+E   + L    ++    ++LD V++ K         
Sbjct: 68  LESLT-DIDFSAIKIGLLPNKKILEMTKKWLTALSVKSPVPIILDPVIVFKENADYSVSE 126

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-H 179
                 S+L P  ++ITPNL EA  L      +TE +M    + L   G   V++KGG  
Sbjct: 127 MRELFISQLFPLATVITPNLKEAEILTGL-SVKTEADMKAAAKLLHRFGAKNVIIKGGNR 185

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D +Q+ D+ +  +   +  +P ++ KN +G GCT ++++A+      ++ D+V++AK +
Sbjct: 186 FDQKQAIDFAYDGKDFYQLASP-LLQKNNNGAGCTFASSIASQMAEENSFKDSVEKAKDF 244

Query: 240 LSSALAQADTLEV 252
           +  A+  A+   V
Sbjct: 245 VYQAIQNANEFGV 257


>UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Lactobacillus brevis ATCC 367 RepID=Q03NL9_LACBA
          Length = 264

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 85/252 (33%), Positives = 129/252 (51%), Gaps = 4/252 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D   G GIQADLKTF  L  +G SV+T++V+     +++   +  + +A QL
Sbjct: 3   NVLTIAGSDSLAGGGIQADLKTFEELHTFGLSVLTSVVSVLPDELKAFQ-LPAEVMATQL 61

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            SVF  V I   K G+L     +    + L+  QI  VV+D VM+ K G   ++P  +  
Sbjct: 62  TSVFDQVPIKAVKTGLLGNLTALTLAVKCLRSSQIS-VVVDPVMVFKEGPLQVTPEYLTA 120

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L+  LLP  ++ TPNL EA  L         ++M+   R + A+GC  V++KGG  L   
Sbjct: 121 LKETLLPLATITTPNLLEAQQLSGLT-ITNREQMVAAARQIQALGCPNVVIKGGSRLGGS 179

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            +PD L   +      AP I+   + G GCT SAA+ A   +     + V  AK ++ +A
Sbjct: 180 VAPDCLLIGDDVTWLEAPIILNAASDGAGCTFSAAITAQLAKGQELLEAVTFAKKFVHAA 239

Query: 244 LAQADTLEVGHG 255
           +     +   +G
Sbjct: 240 ITHGVAISHDYG 251


>UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynthesis protein thiN
           n=5 Tax=cellular organisms RepID=B0R885_HALS3
          Length = 445

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 111/262 (42%), Positives = 150/262 (57%), Gaps = 6/262 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              ALTIAG+D  GGAGIQADLKTF A  A+G S ITA+ AQNT GV     + P+ V A
Sbjct: 2   HPVALTIAGSDSGGGAGIQADLKTFEAGDAFGTSAITAVTAQNTHGVTHSDILAPETVRA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V +D  +   K GML +  +V+AVA  L       V +D V++++SGD LL+ S +
Sbjct: 62  QIDAVTTDFDVSAVKTGMLGDAAVVDAVATALAETPA-PVTVDPVVVSQSGDRLLTESGI 120

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A +R  LLP+ +L TPN+PEA  L D      E ++     ++  +G  A L+ GGHLD 
Sbjct: 121 AAVRDELLPRATLATPNIPEAELLAD-TEITDETDLRAAAEAVCELGPDATLLTGGHLDG 179

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +  P  +F  +    FT PRI T  THG+GCTLSAA+ A           V+     +++
Sbjct: 180 D--PVDVFAGDTTSAFTRPRIETPTTHGSGCTLSAAITARLAHGDALRPAVERGIDAVAA 237

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+     L VG G GPV H HA
Sbjct: 238 AI--DGDLSVGGGDGPVDHRHA 257


>UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=Prevotella
           RepID=D1W4K2_9BACT
          Length = 357

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 87/264 (32%), Positives = 145/264 (54%), Gaps = 8/264 (3%)

Query: 1   MK-RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK R   LTI G+D SGGAGIQAD+K  ++LG Y  SVIT++  QNT G+Q  Y I  D 
Sbjct: 1   MKQRNTILTITGSDGSGGAGIQADIKVITSLGGYAVSVITSITMQNTLGIQRFYDIPADI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           VA Q++++  D++    K+GM+     +E V   L + Q   ++ D V+ +  GD L+ P
Sbjct: 61  VAEQVEALVDDIKPSVVKVGMVRNVKTLENVVSILAKRQPLKLIYDPVVTSSQGDLLMPP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             + +++++LLP  SL+     +AA LL++P  +T  +++   R LL MGC AVL+  G 
Sbjct: 121 EMIDSVKTKLLPLCSLVILKQNDAAYLLNSP-LKTHDDIVNGMRKLLNMGCRAVLLHSG- 178

Query: 180 LDDEQSPDWLFTREGEQRFT-APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            DD     W   ++G+     +P +   N HG G  L++A+A       ++ + +    +
Sbjct: 179 -DDHDFIAW--QQDGDIHVEPSPTLWQTNAHGLGSNLTSAIAYFLGETDDFREAISRGNA 235

Query: 239 WLSSALAQADTLEVGHGIGPVHHF 262
           ++   +++   L+ G G   ++ F
Sbjct: 236 YIHQQMSEMGELK-GRGSELLNAF 258


>UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SEE1_CHRVI
          Length = 272

 Score =  240 bits (613), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 83/251 (33%), Positives = 123/251 (49%), Gaps = 13/251 (5%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L + G DPSGGAGI AD +   A  A+  +VITAL  Q+T G+  ++   P+ + A
Sbjct: 9   RPLVLCVGGHDPSGGAGILADAEVVQAARAFPLTVITALTEQDTCGLAQIHPQPPEQIEA 68

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-----NVVLDTVMLAKSGDPLL 117
               + SD      KIG++   DI   +A  +            VVLDTV+   +G  + 
Sbjct: 69  HCRRLLSDSPPSALKIGLIGGADIARMLARFIDTLATAERARVPVVLDTVLATGAGQSVA 128

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
             +    +R  L+P+ +L+TPNLPEA AL  A          +    LLA G   VL+ G
Sbjct: 129 DAALREAVREALIPRCTLVTPNLPEARALTGA------DAPEDCAERLLAAGAPWVLITG 182

Query: 178 GHLDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
            H   E   + LF   GE+  +  PR+     HG+GCTL++A+AA           V+ A
Sbjct: 183 THDATEAVTNRLFGSNGERHAWDWPRL-PGEYHGSGCTLASAIAARLAHGMTLIQAVESA 241

Query: 237 KSWLSSALAQA 247
           +++  +AL +A
Sbjct: 242 QAYTWTALERA 252


>UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosphate
           pyrophosphorylase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SG79_METPP
          Length = 532

 Score =  239 bits (611), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 97/262 (37%), Positives = 134/262 (51%), Gaps = 8/262 (3%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R    +IAGTD  GGAG+ AD +   A G + C V++A+ AQN+  V  + R+ P  + A
Sbjct: 8   RPVVWSIAGTDSGGGAGLSADQRAADAFGVHLCPVVSAVTAQNSLAVTRIERLPPLALEA 67

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAER---LQRYQIQNVVLDTVMLAKSGDPLLSP 119
           QL+++  D+     K G+L   + V  VA     L+R Q   +V+D V+ A SG     P
Sbjct: 68  QLEALADDLPPQVVKTGLLGGAEHVRRVAHWIDRLRRRQPVALVVDPVLAASSGATFADP 127

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +A  R  LLP+ +LITPN  EAAALL  P A T   +  Q  +L   G  AV + GG 
Sbjct: 128 DTLAAYRELLLPRATLITPNRREAAALLGQPEAGTAG-LPAQALALRRRGAQAVCITGGD 186

Query: 180 LD--DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
               D +  DW+ T + +    APRI T + HG+GCT +++ AA        AD +  AK
Sbjct: 187 AADLDGRVLDWMATEQADGWLAAPRIATPHHHGSGCTFASSAAAALALGFVPADALVLAK 246

Query: 238 SWLSSALAQADTLEVGHGIGPV 259
                AL  A     G G GPV
Sbjct: 247 MATGHALRHAH--PAGAGRGPV 266


>UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RU47_CENSY
          Length = 438

 Score =  239 bits (611), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 87/258 (33%), Positives = 125/258 (48%), Gaps = 7/258 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT+AG+DPS GAGIQ DL T S +G  G SVITA+ AQN+ G      +    VA Q
Sbjct: 7   PYVLTVAGSDPSSGAGIQGDLGTISRMGCTGLSVITAITAQNSSGFTGAEPVPTSMVALQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V SD  +   K+GM+    ++ AV+  L+   +  VVLD VM + +G  LL  +A+ 
Sbjct: 67  MQAVLSDYDVSAVKVGMVLTVPVIRAVSRGLEELDV-PVVLDPVMHSTTGGRLLDDAALP 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   L+ +  ++TPN  E A L     A T  +       LL  G GAV + G      
Sbjct: 126 ALSKHLVSRADVVTPNASELAVLSGMK-AGTAVQARTAATKLLDRGAGAVAVTGL-AGRG 183

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D + T +     +  RI  ++ HG GC  SAA+AA   R        +EA      +
Sbjct: 184 KIYDQVVTSKEHFEVSGRRIRGES-HGGGCAYSAAMAASLARGMGLKAAAREAAEHSRRS 242

Query: 244 LAQADTLEVGHGIGPVHH 261
           +A   +   G G+  V H
Sbjct: 243 IASTRS---GRGLPTVSH 257


>UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella chejuensis KCTC
           2396 RepID=Q2SQL4_HAHCH
          Length = 487

 Score =  239 bits (611), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 89/257 (34%), Positives = 133/257 (51%), Gaps = 8/257 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
                IA +D +G +GIQADL T   L  +G   +TA+ AQN++ V S+  +    +  Q
Sbjct: 6   PKVWIIAASDSAGASGIQADLATLRGLEVHGGVALTAVTAQNSQEVLSINPVATAVLRDQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L ++ +D      KIG+L + + V+ + E L  Y    VVLD V+ + +G       +VA
Sbjct: 66  LRALRADGDAVAIKIGLLTDAEQVDVLREFLCAYS-GLVVLDPVLGSSTGAGFG--MSVA 122

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-D 182
            L+S LLP V ++TPN+PEA  L D     +  +ML     L  +G   V +KGGHL   
Sbjct: 123 ALKS-LLPYVDVVTPNIPEAEQLAD-RRISSPADMLSAAVRLRELGAKGVWLKGGHLGLG 180

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           EQ  D ++  E    F  PR+  ++  GTGCTL++ALAA   R  +  D    A +++  
Sbjct: 181 EQCLDLVWLSEQPYWFAQPRLSVRHHRGTGCTLASALAAFVARGESLLDAAALANAYVKQ 240

Query: 243 ALAQADTLEVGHGIGPV 259
            L Q     +G G GP+
Sbjct: 241 GLRQG--YAIGPGPGPI 255


>UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9D1C6_WOLRE
          Length = 260

 Score =  239 bits (610), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 91/256 (35%), Positives = 132/256 (51%), Gaps = 13/256 (5%)

Query: 1   MKRI--NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD 58
           MK    N L IAG+D  GGAGIQAD+KT  A G Y  + ITAL AQNT GV +V  + P+
Sbjct: 1   MKNPKKNILIIAGSDSIGGAGIQADIKTCEAYGCYSATAITALTAQNTSGVSAVMPVTPE 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
           F+ AQL++V ++++ D  KIGML    ++  V   L++ +  + V+D V +AKSG  LL 
Sbjct: 61  FLNAQLEAVCAELKFDAVKIGMLFNEQLIACVKAWLEQNRGISAVIDPVCVAKSGAKLLQ 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+  L+  LL    + TPNL EA  L        + E L  G  L    C  VL +  
Sbjct: 121 DGAINALKE-LLSLARIATPNLDEARIL----GLNFDGERLNLGADL---PCDIVLKRT- 171

Query: 179 HLDDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
               E   D L+ + GE  +F  P       HG GC+ + A+A       +    ++ AK
Sbjct: 172 -QTSEICEDTLYQKSGEIVKFGEPLERPTIMHGAGCSFATAIACALACGADEITAIKHAK 230

Query: 238 SWLSSALAQADTLEVG 253
           +++++A+  A     G
Sbjct: 231 AFVANAIKNAHGSNFG 246


>UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q756M8_ASHGO
          Length = 316

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 94/269 (34%), Positives = 136/269 (50%), Gaps = 11/269 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LT+AG+D SGGAGI+AD+KT +  G Y  + I+A+ AQ  R V +V       +AA L
Sbjct: 24  TVLTVAGSDSSGGAGIEADIKTITMHGCYAMTCISAITAQTPRAVDAVRATPAPLLAAVL 83

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPSAVA 123
             +F D+ +D  K GML     V+ +   L+ ++    +V+D VM A SG PL   +  A
Sbjct: 84  RGLFRDMAVDAIKTGML-TPAAVDCLLAALRDHRFAGPLVVDPVMAASSGSPLTDLAGPA 142

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL--D 181
                   + +L+TPN+PEA  LL A    +   ++   ++L      AVL+KGGH    
Sbjct: 143 ARALL--RRAALVTPNVPEACRLLAAQPPASPDGLVSLAQALARDLSTAVLLKGGHCPYP 200

Query: 182 DEQSPDWLF---TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            +   D L       G   F A R+ T +THGTGCTL+AA+AA   R  +  + V     
Sbjct: 201 PDAVLDVLVDPADPAGPVTFCARRLSTPHTHGTGCTLAAAIAANLSRAMSLREAVYRGII 260

Query: 239 WLSSALAQADTLEVGH--GIGPVHHFHAW 265
           ++  A+A      V      GPVHH +A 
Sbjct: 261 FVHHAIALQPERSVCALPENGPVHHAYAL 289


>UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacter butzleri RM4018
           RepID=A8EVM9_ARCB4
          Length = 251

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 75/244 (30%), Positives = 126/244 (51%), Gaps = 13/244 (5%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K+    G +  + ITA+  QNT GV +V  ++P FV  Q+ SV  D +++  KI
Sbjct: 17  GIQADIKSGFYHGIFMTTAITAITVQNTLGVTNVEVLKPSFVQEQISSVLEDFKVNAIKI 76

Query: 79  GMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           GML   +++  V + ++      ++LD V ++++G  L+   A+ TL++ L     +ITP
Sbjct: 77  GMLGSKELILKVLDCIKPL-YIPIILDPVAISRAGSKLIDDEAIETLKT-LFKYAFVITP 134

Query: 139 NLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR- 197
           N  EA    D       + +              +L K    D  ++ D L  ++G    
Sbjct: 135 NKYEAKLFFDVNSIDDIKNIKHI--------PTNILFKNMVEDKNKTVDVLLKKDGTIIN 186

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F + R    NTHGTGC+ SA++A+L  +     D+++ AK ++  A+  A  L  G+G G
Sbjct: 187 FESKRADESNTHGTGCSFSASIASLVAKGETLEDSIKIAKKYIYEAIKHAPNL--GNGNG 244

Query: 258 PVHH 261
           P++H
Sbjct: 245 PINH 248


>UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter concisus 13826
           RepID=A7ZEN6_CAMC1
          Length = 254

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 83/256 (32%), Positives = 134/256 (52%), Gaps = 21/256 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           + + N L +AG+D  GGAG+QAD+K+  A   +  SVITA+ AQNT GV SV  +  + V
Sbjct: 5   VSKKNVLIVAGSDSVGGAGVQADIKSCEAFSCFSASVITAVTAQNTNGVSSVLAMPANMV 64

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ--NVVLDTVMLAKSGDPLLS 118
            AQ + V +++ ID  K+GML   +I+  V+  L+  + +   VV+D V +AKSG  LL 
Sbjct: 65  KAQFEMVLAELDIDAVKVGMLFNEEIIAVVSAFLKELRAKNVPVVIDPVCVAKSGAKLLE 124

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+  L+  LL   S+ TPN+ EA  L               G     + C  VL +  
Sbjct: 125 DGAIEALKE-LLNLASVATPNVDEARIL---------------GIDFANLPCDMVLKRT- 167

Query: 179 HLDDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
              DE   D L+ + G+  +F+      +  HG GC+ S++LAA+  + ++    ++ AK
Sbjct: 168 -KVDEICEDTLYLKNGDAMKFSEELFEPRVMHGAGCSFSSSLAAILAQQSDLVSAIKMAK 226

Query: 238 SWLSSALAQADTLEVG 253
            ++++ +  A   + G
Sbjct: 227 KFVANGIKNAHKSKFG 242


>UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7E450_SCLS1
          Length = 400

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 83/254 (32%), Positives = 131/254 (51%), Gaps = 21/254 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD K  +A   Y  +  TAL AQNTRGV+ ++ I  +FV
Sbjct: 1   MGIGRVLVIAGSDSSGGAGLEADQKVIAAHECYAMTATTALTAQNTRGVEDIHHIPAEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
              +D    D+ +D  K    A  + VE VA+ L+R+ ++ +++D VM++ SG  LL   
Sbjct: 61  GKLIDVTIGDMGVDVVKT---ASAETVEVVAKALKRHHVKTLIVDPVMISTSGTQLLPSI 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLD-----APHARTEQEMLEQGRSLLAMGCGAVLM 175
           A+  LR  LLP  +++TPN+PEA  LL          +   ++    + + ++G   VL+
Sbjct: 118 AIRHLRELLLPYTTVLTPNVPEAKLLLSDAGKFVEEPKNLDDLKNIAKEVQSLGPRYVLV 177

Query: 176 KGGHL-------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL             + E   D L+              ++NTHGTGC++++A+A+ 
Sbjct: 178 KGGHLPLRKDGTVATKEEEKELMVDILYGEGVITEIRTKYQNSRNTHGTGCSMASAIASN 237

Query: 223 RPRHTNWADTVQEA 236
             +       V+ A
Sbjct: 238 IAKGIPLVQAVRSA 251


>UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0L0X1_HALNC
          Length = 285

 Score =  237 bits (606), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 85/254 (33%), Positives = 135/254 (53%), Gaps = 5/254 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L  +G DPSGGAG+QAD++   + G +  +VITAL  Q+T  V+     +P  V  Q
Sbjct: 9   PVVLVFSGHDPSGGAGVQADIEAIISQGVHPATVITALTVQDTVDVKRFVPTDPSLVIEQ 68

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             +V  D+ +   KIGM+    +VE +   L+ Y    VVLD V++A  G  L +     
Sbjct: 69  ARAVLEDMPVQCIKIGMIGSVALVEVIHSILKDYPDIPVVLDPVLIAGGGGALANEDVAK 128

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            + + LLP  +++TPN  E+ AL+   H     ++  +G+ LL MG   VL+KGG     
Sbjct: 129 AMINLLLPLTTILTPNAYESRALVKVAHVP-ANDLDARGQVLLEMGPEYVLLKGGDEQST 187

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPR--HTNWADTVQEAKSWL 240
           +  +WL+TR    ++FT  R+     HG+GCTL++A+A L  +    ++ + + EA+ + 
Sbjct: 188 EVENWLYTRHQPPRKFTYERL-PGEFHGSGCTLASAIAGLIAQATDADYVNAIHEAQEYT 246

Query: 241 SSALAQADTLEVGH 254
           S AL  A  +  G 
Sbjct: 247 SHALFHAAQIGRGQ 260


>UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G3W4_PHATR
          Length = 580

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 84/292 (28%), Positives = 134/292 (45%), Gaps = 62/292 (21%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADL    + G +GCS IT L AQN+ GV  V+   PDF+ AQL+++  D+     KI
Sbjct: 52  GIQADLHAIHSFGCHGCSAITCLTAQNSVGVIGVHAPPPDFLRAQLETLLEDLPPQAIKI 111

Query: 79  GMLAETDIVEAVAERLQRYQI----QNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           GML   ++   V   L++ +       VVLD VM+  SG  L+   A   +   + P + 
Sbjct: 112 GMLGTKELAIEVGAFLKKLKALDRKVWVVLDPVMITTSGHRLIEEDAQEAMVKHVFPHID 171

Query: 135 LITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--LDDEQSPD----- 187
           ++TPN  EA ALL+     T  ++ E  + L+A+G  +VL+KGGH   +  ++ +     
Sbjct: 172 VLTPNKFEAEALLNRT-LETISDVEEGAKDLIALGAPSVLIKGGHTLYEGGKASNHIAYA 230

Query: 188 ---------------WLFTREGEQRFTAPRIMTKNTHGTGCTL----------------- 215
                           L   +      +PR  T++THGTGCTL                 
Sbjct: 231 QDYFLSSVQRNTGEPRLCDGDLGVWLRSPRYETEHTHGTGCTLSASLAASLALGEQERQK 290

Query: 216 --------SAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
                   ++A+        +  D    AK+++++ +     +++G G GPV
Sbjct: 291 PDGKRRGATSAI--------DTVDACCLAKAYVTAGIFHG--IQLGQGPGPV 332


>UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQ01_9BURK
          Length = 277

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 84/253 (33%), Positives = 122/253 (48%), Gaps = 9/253 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT + +DP+ GAG+QAD  T SALGA+  +++T L AQNT GV       PD++  Q
Sbjct: 6   PLVLTFSASDPTAGAGLQADALTVSALGAHPLTILTGLTAQNTAGVARFEACTPDWIDDQ 65

Query: 64  LDSVFSD-VRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           L ++  D +     K G+L  T  V AV +    +    +V+D V  +  GD        
Sbjct: 66  LTALLDDGISPSAIKTGVLGSTAAVAAVLKAKSLWPSVPLVVDPVRASGRGDAFGGQGLF 125

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
              R++L P V L+TPN PEA A   A          E G  LL MGC AVL+KG HL+ 
Sbjct: 126 DYYRNQLFPAVDLLTPNWPEAQAFTGAQTVD------EAGERLLKMGCKAVLLKGEHLES 179

Query: 183 EQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
               + L+   +    F   R+     HG+GCTL++A A    +  +  + V+ A  +  
Sbjct: 180 GDIVNRLYRPGQPVVEFPCERL-PGQYHGSGCTLASACAVGLGQGLSVQEAVELALEYTW 238

Query: 242 SALAQADTLEVGH 254
            AL+    +  G 
Sbjct: 239 QALSCGFVVGKGQ 251


>UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 open reading frames
           n=3 Tax=Pichia angusta RepID=Q04326_PICAN
          Length = 379

 Score =  237 bits (605), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 91/287 (31%), Positives = 135/287 (47%), Gaps = 31/287 (10%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT+AG+D SGGAGI+AD+KT +A   Y  + ITAL AQN+ GV +V     + V   
Sbjct: 33  PRVLTVAGSDSSGGAGIEADVKTITAHKCYAVTCITALTAQNSLGVHNVTTTPAETVEKV 92

Query: 64  LDSVFSDV-RIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSA 121
           L ++  D   +D  K+GML + + +  +   L     +  +VLD V +AK+GD L S  A
Sbjct: 93  LVAIADDQIALDAIKLGMLPD-ETLSVITPFLAARAARTPIVLDPVFVAKNGDRLSSVGA 151

Query: 122 VATLRSRLLPQVSLITPNLPEAAALL----------DAPHARTEQEMLEQGRSLLAMGCG 171
           +      L    +LITPN  E   LL          +     T  +     R L +    
Sbjct: 152 LKKAVE-LFQHAALITPNSREVEVLLAVLRSSDPSVEEITITTADDFYTAARLLGSRFKV 210

Query: 172 AVLMKGGHLD-------DEQSPDWLFTREGEQR------FTAPRIMTKNTHGTGCTLSAA 218
            VL KGG +        D ++P ++     E R      F +  I + N HGTGCTLS+A
Sbjct: 211 DVLFKGGLVPVNENLAVDPENPVYILNVLYEHRSEKLTVFRSNHIDSPNLHGTGCTLSSA 270

Query: 219 LAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           +A    R  + A  V+ A  +++ A+  A+        GP++H  A 
Sbjct: 271 VACYLARGASLATAVENAIGFVNEAIRHAEV----KPNGPLNHTWAI 313


>UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C31AB2
          Length = 284

 Score =  236 bits (604), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 96/243 (39%), Positives = 131/243 (53%), Gaps = 9/243 (3%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADLK F+A G +G + ITAL AQNT GV +V  I P+ + AQ+ +V  D+ ID  KI
Sbjct: 31  GIQADLKVFAACGVHGMTAITALTAQNTVGVDAVAPIAPEMIVAQVRAVARDIGIDAVKI 90

Query: 79  GMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
           GML     +EAV   L        +VLD VM+++SG PLL P A   L   LLP+V++ T
Sbjct: 91  GMLGTVVTIEAVVAALGELAEGTPIVLDPVMVSESGAPLLEPEARDALIELLLPRVTVAT 150

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR 197
           PNLPEA  +       ++ +  E  R++ A+G   V++ GGH D  ++ D +F  E    
Sbjct: 151 PNLPEARVIAG-----SDDDAPELARAIHALGPRHVVVTGGHRD--KATDVMFDGETTIE 203

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
               R      HG+GCT S+ALAA         D  + AK   + A+      E+G G G
Sbjct: 204 IPGERHPDGAAHGSGCTHSSALAAHLALGFAPVDAARAAKVIAAQAVHDGLR-EIGRGPG 262

Query: 258 PVH 260
           PV 
Sbjct: 263 PVD 265


>UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospirillum
           ferrodiazotrophum RepID=C6HXY3_9BACT
          Length = 270

 Score =  236 bits (603), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 96/250 (38%), Positives = 133/250 (53%), Gaps = 6/250 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   AL++AG DPSGGAG+  DL+ FSALG  G  V T L  QN +GV     + P+ +
Sbjct: 1   MK-GYALSVAGLDPSGGAGLYQDLRVFSALGIRGQGVPTVLTVQNLQGVGRTEPLSPELL 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSP 119
           +A L++V  +      KIG++A + +VE +A+ L       V +LD V L  +G  +L+P
Sbjct: 60  SAMLEAVVGEGPPRAVKIGLMASS-LVEELADFLDGLPKDVVRILDPVFLFGTGGSVLTP 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGG 178
            A   L   L P+V L+TPNLPEA  L         ++++   R L    G  AVL+KGG
Sbjct: 119 PAYRDLARSLFPRVDLVTPNLPEALELGGEIPGSRPEDLVLMARRLHDQYGVRAVLLKGG 178

Query: 179 HLDDEQS-PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHT-NWADTVQEA 236
           H + E+   D  +T  GE+ F+ P       HG GCTLS+ +AAL  R   +  D V  A
Sbjct: 179 HRNGEEPRTDLFWTPSGERFFSHPFRRLPGVHGGGCTLSSLVAALLVRGESSLIDAVARA 238

Query: 237 KSWLSSALAQ 246
                  LAQ
Sbjct: 239 LELYQMLLAQ 248


>UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobacteriaceae
           RepID=Q11F75_MESSB
          Length = 256

 Score =  236 bits (602), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 96/248 (38%), Positives = 144/248 (58%), Gaps = 3/248 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + L +AG+D SGGAG   D++  ++LG      ITA+ AQ    V +V  + P  V+A
Sbjct: 4   RPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++      ID  KIGML  +DIVEAV+  L+R+    VVLD V+ + SG  L+  + +
Sbjct: 64  QMEAALEAEPIDAIKIGMLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A L+  LLP   L+TPN  E A L     A +E+E L+QG  LLA GC A+L+KGGH  D
Sbjct: 124 AVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALDQGNLLLASGCHALLVKGGHAPD 183

Query: 183 EQSPDWLFTREGE--QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +++   +  R G   +RF APR+ ++   GTGC L++++AA   R  +  +++   K  +
Sbjct: 184 KRNSTDILLRRGHAPERFEAPRLDSR-MRGTGCALASSIAAALARGLSLEESIAFGKRKV 242

Query: 241 SSALAQAD 248
              L +AD
Sbjct: 243 YHLLREAD 250


>UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Proteobacteria
           RepID=C0N961_9GAMM
          Length = 480

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 77/266 (28%), Positives = 127/266 (47%), Gaps = 9/266 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +   L I G DP G AGI AD+ T      +   +ITA+  Q++ G+ ++  +  + +
Sbjct: 1   MAKPAVLLIGGLDPQGCAGIAADIATVQHHDCHPLPLITAMTEQSSAGLTALGAVNTNKL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ  +  +D  I   K+G++ +  I E V + L       VV+D V+ + SG   ++  
Sbjct: 61  MAQYRNCKADFDIQAIKVGLIPDLIIAEKVKQILLDNPGIPVVMDPVLASSSGGKTVADG 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               +R  LL  ++L+TPNLPE + L D       +++ +    L   G  A L+KGGH 
Sbjct: 121 VRQYIRDELLQHLTLLTPNLPELSLLTD-----NLEDVEQATTILSQKGLQACLVKGGHA 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D E + D  F  E  + +        +  GTGC L++A+A+      +  D V  AK+++
Sbjct: 176 DSEFATD-FFISEQVRFYCYQTKYASDVRGTGCVLASAIASHLASGQDMRDAVVLAKTYV 234

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           S  + QA T+        + H H  W
Sbjct: 235 SRGIRQAQTVGS---YRLIKHSHEPW 257


>UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales RepID=A2BMS2_HYPBU
          Length = 475

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 94/258 (36%), Positives = 135/258 (52%), Gaps = 7/258 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             A+T+AG DPSGGAGI ADLK F+A+G +G  V+  +  Q+TRGV+ V+ +    V  Q
Sbjct: 19  PVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQ 78

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  D R+   K G+L   + VEA+A  L+   I  +V+D V  A +G  L S  A  
Sbjct: 79  LQAVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIA-LVVDPVYRASAGQLLNSDDAFK 137

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDD 182
            +   L P  SL+ PN+PEA  +      R+ ++     R L+   G  A L+KGGHL  
Sbjct: 138 AIVEELFPLASLVAPNVPEAERITG-TRIRSIEDAKRAARILVEDYGARAALIKGGHLPG 196

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E   D L+  +    F   R  +  +HGTGCT +AALAA   +  +  + V  A+  +  
Sbjct: 197 EP-VDVLYYEDVFWEFRGERR-SGCSHGTGCTFTAALAAGLAKGLDLVEAVVRARKLVEE 254

Query: 243 ALAQADTLEVGHGIGPVH 260
           A+       VG G  PV+
Sbjct: 255 AIEYG--FRVGRGDCPVN 270


>UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DPJ2_9BACT
          Length = 272

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 120/255 (47%), Gaps = 5/255 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LTIAG D  G AG+QADL+ F+    +  SV++A  AQ+   V SV  +      
Sbjct: 4   KLNTCLTIAGADSGGEAGVQADLQVFNYFNCHALSVLSATTAQSYSRVLSVNPVGITAFE 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+ VFSD +    K GML + + +    E  ++     +V+D +M++ SG  LL  SA
Sbjct: 64  DQLEVVFSDFQPACIKTGMLVDGEYINVFLE--RKPSSAQLVVDPLMMSTSGTELLEKSA 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              +R  L+P  +++TPN PE   LL        +EM+++   L+      V +KGGH  
Sbjct: 122 WGVMRDLLIPSANMVTPNFPELRFLLGIDEVMCGEEMVQRYFDLVQ---VPVYLKGGHNA 178

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           +  S D+     G        +  K +HGTGC +S+AL A      +        K +L 
Sbjct: 179 EAPSIDFFIDESGLWSLKTDELEIKASHGTGCRVSSALTAGLSNGLSGLQAAINTKKYLH 238

Query: 242 SALAQADTLEVGHGI 256
            +L     L  G  +
Sbjct: 239 QSLKSYKALSDGQYV 253


>UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U779_HYDS0
          Length = 259

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 72/251 (28%), Positives = 136/251 (54%), Gaps = 6/251 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK I  L  AG D + GAG+ AD +T + +GA+   + T+ V QNT+GV+ V  +EPD +
Sbjct: 1   MKSI-VLVFAGYDQTSGAGVIADARTITCIGAHPVCITTSFVIQNTKGVKEVIFLEPDII 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
              +D +  DV+    KIG++ +   +  +++ +   + ++VV+DT + +K+  PL    
Sbjct: 60  KKHIDIL--DVKPKVVKIGVVGDDKAIRLISKAIDTLKPEHVVVDTPLFSKNDTPLFK-- 115

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           ++   +  ++ + ++ITPN+ EA+ +      +T+ ++ +     L MG   V++KGGH 
Sbjct: 116 SLELYKDLIVSKATIITPNIKEASFITGI-DIKTKNDIEQAANVFLDMGVKHVVIKGGHR 174

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +DE   D+  + E         I T+ THGTGC  ++++A+      +   ++ +AK ++
Sbjct: 175 EDEPGVDFYKSMEESFEIKKDFIETRTTHGTGCVYASSIASYLAIGNDVKASIIKAKDYV 234

Query: 241 SSALAQADTLE 251
             A+ Q   L 
Sbjct: 235 DRAIKQGYMLN 245


>UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UMB7_AKKM8
          Length = 257

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 89/242 (36%), Positives = 128/242 (52%), Gaps = 4/242 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +TIAG+D S GAG+QADLK   A+GA+  + +T +V++    V+ +  ++P  VA Q+  
Sbjct: 2   MTIAGSDCSAGAGLQADLKAAHAMGAFALTAVTCVVSEAPGTVRGIQEVDPSLVADQVRI 61

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
                 +   K GML    IV AV   L    I  VV+D VM+A +GD L+   AVA   
Sbjct: 62  NLEHFPVRAVKTGMLYSPAIVRAVHGVLDGADI-PVVVDPVMIATAGDRLMREEAVAVYE 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP  +L+TPNL EAA LL +       E+ E    L       VL+KGGHL+ +   
Sbjct: 121 ELLLPGAALLTPNLDEAAVLLRSSVNPGRDELPEAAARLAVRYGCPVLLKGGHLEGD-CR 179

Query: 187 DWLFTREGEQ--RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           D L   +G    ++  PR+   +THGTGC+LSAA+AA           V+    +++SA+
Sbjct: 180 DVLSGPDGCLLGQWERPRVQDVSTHGTGCSLSAAVAARLAAGDGLVAAVERGLEFIASAI 239

Query: 245 AQ 246
             
Sbjct: 240 RN 241


>UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepID=Q6FDT4_ACIAD
          Length = 259

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 79/248 (31%), Positives = 119/248 (47%), Gaps = 9/248 (3%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L  +G DPSGGAG+QAD+++    GA+     TAL  QN++ V        + + A
Sbjct: 2   RPTVLCFSGLDPSGGAGLQADIESIGQSGAHAAIACTALTIQNSQQVFGFEATSKELLLA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++V  D+ I   K GML  T+ + A+A+ L+ +     VLD V++A SG  L   + +
Sbjct: 62  QANAVVVDLPIKCVKSGMLGTTENIAALAQFLREHPDYQYVLDPVLVANSGGSLGDQATL 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--L 180
                 L+P  ++ITPN  E  AL           + +  + L  MG  A+L+KGGH   
Sbjct: 122 VKAFVELIPLATVITPNTVELRALTGL------DNIEDATQKLFDMGAQAILVKGGHEAT 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            D          E     T PR+     HG+GC+L++ +A       +    VQ A+ WL
Sbjct: 176 PDHIHNQLFIKGELVAESTCPRLE-GEYHGSGCSLASYIAGRLALGDDLKIAVQHAEVWL 234

Query: 241 SSALAQAD 248
              L QA+
Sbjct: 235 FDVLKQAE 242


>UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobacter formigenes
           RepID=C3X5F6_OXAFO
          Length = 272

 Score =  233 bits (596), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 81/262 (30%), Positives = 132/262 (50%), Gaps = 15/262 (5%)

Query: 1   MK---RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK   R   L  +G DPSGGAGI AD++   A+GA+   V+TAL  Q+   V +V  ++ 
Sbjct: 10  MKEKSRHCVLVFSGLDPSGGAGISADIEAIGAVGAHALPVVTALTVQDNDRVYAVNPVDA 69

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ----NVVLDTVMLAKSG 113
             ++ Q   +   + +   K+G++   D   A+ E +   + +     VVLDTV+ +  G
Sbjct: 70  AIISRQAQVLAGKIPVSAVKVGIVGNRDNAVAIGEVISELRRKQPGLPVVLDTVLGSGHG 129

Query: 114 DPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAV 173
             L   +    L S L+   +L+TPNLPEA  L          +  +Q   L+A G   V
Sbjct: 130 FALADGTPEYAL-SPLIGMATLVTPNLPEAKRLCPLAK-----DTRKQAEYLMAQGAANV 183

Query: 174 LMKGGHLDDEQSP-DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           L+KGGH +D  S  +  F  +G +++   R +    HGTGCTL++A+AA   +       
Sbjct: 184 LIKGGHGEDADSVFNQWFGADGMKQWKW-RRLPGEFHGTGCTLASAIAAYLAQGLLMEKA 242

Query: 233 VQEAKSWLSSALAQADTLEVGH 254
           +++ + W  +AL +A ++  G 
Sbjct: 243 LEKGQVWCQAALEKAFSIAKGQ 264


>UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomycetales
           RepID=A4XBK7_SALTO
          Length = 262

 Score =  233 bits (595), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 110/263 (41%), Positives = 147/263 (55%), Gaps = 6/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     LTIAG+D  GGAGIQADLK F+AL AYG SV+TA+ AQNTRGV +V  + P  V
Sbjct: 1   MTPSTVLTIAGSDSGGGAGIQADLKVFAALEAYGTSVVTAVTAQNTRGVDAVLPLPPQTV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV +D  +   K GML    + E VA   +  ++ ++V+D V++A SG  L + +
Sbjct: 61  TDQLESVLADFSVRAVKTGMLGSPAVAEVVAVAARDGRLPHLVVDPVLVATSGHRLGAVA 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV     RLLP   + TPN  EAAAL       T +EM+    +L A G   V++ GG  
Sbjct: 121 AV----ERLLPFAQVATPNRAEAAALTGG-RVDTVEEMVAAATALTAGGPEYVVVTGGDG 175

Query: 181 D-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           D  E + D L    G     A R+ T++ HGTGC+ SAA+A    R       V  AK +
Sbjct: 176 DAGEPAVDVLHGEGGTTLLRASRVPTRHNHGTGCSFSAAVAVRLARGDAVPVAVAAAKEY 235

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           ++ AL  A   E+G G GP+ HF
Sbjct: 236 VTRALIGARDWELGAGPGPLDHF 258


>UniRef50_C0X709 Possible phosphomethylpyrimidine kinase n=22 Tax=Enterococcus
           faecalis RepID=C0X709_ENTFA
          Length = 278

 Score =  233 bits (595), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 70/256 (27%), Positives = 122/256 (47%), Gaps = 5/256 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +I  LTI G+DP  G GIQ DLKTF     +G S +T L A   +    ++ +E   V
Sbjct: 8   MTKI-ILTIGGSDPFSGGGIQTDLKTFENHQVFGLSTLTCL-ATAPKNHFQIHDLETSLV 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL S+ +   +D  KIG++   + +  +   L+++    VVLD V+  K    +    
Sbjct: 66  KEQLASIPAG-SLDGIKIGLIHSEESMLQIVTFLKKHAGLPVVLDPVLAFKETTSVYEKR 124

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-H 179
            +  L  +L P  ++ITPNL EA  L+      T +E+ +    L ++G   V++KGG  
Sbjct: 125 YMQLLIEKLFPFATIITPNLKEAELLIGRK-LTTVEEVQQAAEELNSLGAATVVIKGGNR 183

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              +++ D+ +  +   +    ++M     G GC+ ++A+ A   +     + V  AK++
Sbjct: 184 WLGQEARDFFYDGQQHIQLVKEKVMAHTIDGAGCSFASAIGANLVKGYPLIEAVDLAKTY 243

Query: 240 LSSALAQADTLEVGHG 255
           +  A+     L    G
Sbjct: 244 VHEAIVSGVQLNAAFG 259


>UniRef50_B9E8N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=56
           Tax=Bacilli RepID=B9E8N3_MACCJ
          Length = 276

 Score =  232 bits (593), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRG-VQSVYRIEPDF 59
           M     LTIAG+D S GAG+QADLKTF     YG   +TA+VA +      +V  +  + 
Sbjct: 1   MSLKKILTIAGSDTSAGAGMQADLKTFQEYNTYGMVALTAVVAMDPETWAHNVTPLPIEL 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +  Q+ +  S +  D  K GML   +I++  A+  +       V+D VM+ K  D +L+P
Sbjct: 61  LDKQIKTALS-IGPDAIKTGMLGTEEIIQRAAKAFEDSDAAYFVVDPVMVCKGEDEVLNP 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
                +   LLP  +++TPNL EA  L       T ++M E    +   G   V++KGG 
Sbjct: 120 GNTDAMIKYLLPLATIVTPNLFEAGQLSGLGKLTTMEQMKEAAEIIHQRGAKHVIIKGGK 179

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            L+ +++ D  +  +     T  +  +   HG GCT +AA  A      +  + V  AK 
Sbjct: 180 ALESDEALDLYYDGDTYTLLTTDKFQSSYNHGAGCTFAAATTANLALGKSPREAVIAAKG 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           +++SA+      ++   +GPV H
Sbjct: 240 FVASAIKHG--WKMNEFVGPVQH 260


>UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BQI9_9GAMM
          Length = 271

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 76/252 (30%), Positives = 124/252 (49%), Gaps = 7/252 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L  AG DP+GGAGI AD++  ++ G +   +IT++  Q+TR V     +    VAAQ
Sbjct: 7   PIVLVFAGHDPTGGAGICADIQALASQGCHTAPIITSITTQDTRNVFENKPLSSTLVAAQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
            ++V +D+ I   KIG+L   +I+EAV   L ++    VV+D V++A  G  L       
Sbjct: 67  AEAVLADLPIAACKIGLLGSIEIIEAVQHLLLKHPHLPVVVDPVLVAGGGYSLTQDKVRD 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +  +LLP   +ITPN PEA+AL           +      L+  GC  V + G H D  
Sbjct: 127 AMIKKLLPLTQIITPNSPEASALTGIT-----NSLNAAATRLMDYGCQHVCITGTHEDTP 181

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              + L++   + +      +  + HG+GCT +A+LA    +  +    V +A+ +  + 
Sbjct: 182 LVKNTLYSHGQQIQSWTWTRLPHSYHGSGCTFAASLAGFLAQGIDMVTAVYKAQHYTWTT 241

Query: 244 LAQADTLEVGHG 255
           L +    + GHG
Sbjct: 242 LQRG--FKPGHG 251


>UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F6FE
          Length = 274

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 77/260 (29%), Positives = 130/260 (50%), Gaps = 8/260 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNT-RGVQS-VYRIEPDFVAA 62
             LTIAG+D SGGAG++ADLK F   GA+G + +T +V  +   G    +  I+P+ V  
Sbjct: 4   KVLTIAGSDVSGGAGLEADLKMFEEYGAFGTAAVTCIVTFDPNDGFSHVIEFIDPEVVTR 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL+S  +  + D  K GML   +    +A++L+  ++   V D V++ K    ++     
Sbjct: 64  QLESTLAVHKFDAIKSGMLGSVENALVLAQKLKTNEL-PYVFDPVLVCKGAGTMV--DLK 120

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLD 181
                 L+P  ++ITPNL EAA L       + + M+E  + + A G   V++KGG  L 
Sbjct: 121 DLFVDNLVPLATVITPNLEEAATLAGLEPIDSVEGMVEAAKIIHAQGAKNVVVKGGARLA 180

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            E + D +F  E      + ++  K  +G GC+ ++++AA         D V  AK  ++
Sbjct: 181 GEDAIDIVFDGESITTLRSRKVNEKLVNGAGCSFASSIAAGITTGLIIQDAVVSAKEKVA 240

Query: 242 SALAQADTLEVGHGIGPVHH 261
             +  A+ L+   G+  + H
Sbjct: 241 HGI--ANCLDNATGVASLFH 258


>UniRef50_C5RC57 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Weissella paramesenteroides ATCC 33313
           RepID=C5RC57_WEIPA
          Length = 268

 Score =  230 bits (588), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 73/261 (27%), Positives = 129/261 (49%), Gaps = 4/261 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     +TIAG+D   G G+QADL TF+  G +G S IT++V  N      ++ +    +
Sbjct: 1   MVVGKIITIAGSDTLSGGGVQADLATFNEYGLFGLSAITSIVTVNQYDF-DIHEVPISVL 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSP 119
           A QL S+     I   K+G+L     ++ V++ +++Y     +V+D VM  K  D + + 
Sbjct: 60  AKQLTSLGELSDIKGIKVGLLPSVAHIDLVSQFIKQYVGRVPIVIDPVMAFKETDSVNAS 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG- 178
                ++ +LLP  +++TPNL EA  LL      +E ++L     L  +G   V++KGG 
Sbjct: 120 ELSTAIKQKLLPLATVVTPNLIEAE-LLTQQAIHSEADLLTVAEMLHKIGPKTVVVKGGV 178

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            LD + + D + + + ++     +I     +G GCT SAA+A+   ++      + +AK 
Sbjct: 179 RLDGDMASDAVISEDTKKVIKLSKIERPFNNGAGCTFSAAIASQIAQNVPVLMAIDDAKD 238

Query: 239 WLSSALAQADTLEVGHGIGPV 259
           ++   +     L     +G V
Sbjct: 239 FVHHGILHGVNLNDDFKVGNV 259


>UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular organisms
           RepID=B9LWE4_HALLT
          Length = 461

 Score =  230 bits (588), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 104/263 (39%), Positives = 144/263 (54%), Gaps = 5/263 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   LTIAG+D  GGAGIQADLKT  A GA+G S ITA+ AQNT GV S + +  + + A
Sbjct: 18  RPVVLTIAGSDSGGGAGIQADLKTIEAGGAFGTSAITAVTAQNTLGVVSSHVLPIEEIDA 77

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V SD  +   K GMLA   ++  V E +    +  VV   VM+A +GD LL+P A 
Sbjct: 78  QIDAVLSDFDVRAVKTGMLATAPVIAVVTEYVDDLDVPVVVD-PVMVAATGDRLLAPDA- 135

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +   LL   +L TPN  EA  L         +  ++ G++LL  G  A L+KGGH+  
Sbjct: 136 ENVYEDLLAHAALTTPNADEAEVLTGI-ELTDHEGTIQAGKALLETGVDAALVKGGHVPT 194

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           ++  D L T +  + +  PR+ T  THG+GCTL++A+          AD V    S++  
Sbjct: 195 DRVRDVLVTADDVKTYEHPRVDTDATHGSGCTLASAITTRLAHDEPLADAVDAGVSFIER 254

Query: 243 ALAQADTLEVGHGIGPVHHFHAW 265
           A+     L+VG G G VHH  A 
Sbjct: 255 AVRY--HLDVGEGPGSVHHMVAL 275


>UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobacterium modesticaldum
           Ice1 RepID=B0TDW0_HELMI
          Length = 290

 Score =  229 bits (586), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 94/286 (32%), Positives = 137/286 (47%), Gaps = 28/286 (9%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    +TIAG+DPSGGAGIQADLK  +  G YG + +TAL  Q + GV  ++ +   +V
Sbjct: 1   MKLPKVVTIAGSDPSGGAGIQADLKVLAQFGVYGGAAVTALTRQTSAGVLGLFPLPAAWV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAV----AERLQRYQ------------------ 98
             Q+  V  D+R    K GML +  ++  +       LQ Y+                  
Sbjct: 61  LEQISDVLWDLRPPVVKTGMLQQPAVISGLGRLWGAYLQEYRDTAAQVLPPASSTTPAPT 120

Query: 99  IQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM 158
           +  +V+D V+ + +G  L+    +A  R  LLP  +++TPN+PEA AL      R   +M
Sbjct: 121 LPILVVDPVLSSGAGVSLVDGGGLAAFREDLLPVTTVLTPNVPEAEALTGMA-IRDSGDM 179

Query: 159 LEQGRSLLAMGCGAVLMKGGHL---DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTL 215
           +     LL  G   VL+KGGHL   + ++  D L +RE  +     R+   + HGTGC+L
Sbjct: 180 IGAAERLLQFGPQWVLLKGGHLPEWEGDRIADLLISREERRWLWGQRVPRADLHGTGCSL 239

Query: 216 SAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           ++ALAA              A  WL   +     L VG G G V  
Sbjct: 240 ASALAACLALGLPVPVAAARAVEWLRQRI--GSPLFVGQGRGVVCQ 283


>UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
           C18B5.05c n=1 Tax=Schizosaccharomyces pombe
           RepID=YJK5_SCHPO
          Length = 327

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 72/264 (27%), Positives = 131/264 (49%), Gaps = 19/264 (7%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
                LTIAG+D SG AGIQADLK  +A   YG SV+TAL  QN+ G+  +Y + P  + 
Sbjct: 12  NHPTCLTIAGSDCSGAAGIQADLKVMTAHQVYGMSVLTALTCQNSHGITGIYPLHPSLIQ 71

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+D+  SD++    KIGML +   +  +++ L +Y+I +VV+D+V+++  G+ +     
Sbjct: 72  RQIDACLSDIQCRVVKIGMLPDPKSIPVISQALTKYKITDVVMDSVIISSMGNVMCETPT 131

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDA------PHARTEQEMLEQGRSLLAMGCGAVLM 175
           +      L P + +   N+ EA  L++       P  ++  ++      +  +G   V++
Sbjct: 132 IPATIQHLFPHLLVYASNVMEAFILVEKTLKKSPPPLKSFPDIQNLMSIIHRLGPKFVVL 191

Query: 176 KGGHLDDEQ-------------SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           +G H+  ++             + D ++  +    F  P   TK+ HG  C+L+AA+A+ 
Sbjct: 192 RGHHVAFDKNMMITEKPDSKSWTADLIYDGKEFYIFEKPYNTTKSIHGESCSLTAAIASN 251

Query: 223 RPRHTNWADTVQEAKSWLSSALAQ 246
              +      + EA   +  A+ +
Sbjct: 252 LACNIPPLQAIHEALYSIEWAIQR 275


>UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=A7GXD3_CAMC5
          Length = 244

 Score =  228 bits (581), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 76/262 (29%), Positives = 129/262 (49%), Gaps = 23/262 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK  N L IAG+D +GGAG QAD+KT  A G Y  + IT  V +NT+    +  +    V
Sbjct: 1   MK--NILIIAGSDSAGGAGAQADIKTCEAFGCYSATAITVFVCENTQVTYDISSVPASCV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+  +  +++ID  KIGML +   ++ V + L ++ +  +V+D V ++KS   L+   
Sbjct: 59  DSQIRGITEELKIDAVKIGMLFDVQTIKVVEKWLPKFNV-PIVIDPVCISKSNVKLIKDD 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  LR  +L   ++ TPN  EA AL                    ++ C  ++ K  H+
Sbjct: 118 AIDALRG-ILKFATIATPNRYEAQALFH--------------NDFSSLVCDVIVKK--HV 160

Query: 181 DDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            + +S D L  ++G Q  F          HG GCT S A+A    +  +  ++V +AK++
Sbjct: 161 VNGESIDTLHKKDGSQLNFATALADPFIMHGAGCTFSTAIACCLAQGLSLEESVTKAKNY 220

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+      + G  +  ++H
Sbjct: 221 VYQAIKTGLETKFGKTL--LNH 240


>UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9CXT9_WOLRE
          Length = 245

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 79/254 (31%), Positives = 128/254 (50%), Gaps = 21/254 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+I  L IAG+  +GGAG+QAD+K  +  G Y  + +TAL A+NT  ++++  ++P F+
Sbjct: 1   MKKI--LIIAGSCSNGGAGLQADIKACAHFGCYSATAVTALTAENTDKIKNIVSLDPSFI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A QL  + ++   D  KIGML    I++ V   L++     VVLD V ++K G  L+  S
Sbjct: 59  ADQLGMLAAEFSFDAVKIGMLFNEPIMDVVQSFLEK-NSAPVVLDPVCVSKMGHKLIKDS 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L+  L+   ++ TPNL EA  L                     + C  ++ K  H+
Sbjct: 118 AIERLKE-LMKFAAVTTPNLREADVLFG--------------DDFTNLPCDVIVKK--HI 160

Query: 181 DDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              +S D L+ ++G  Q F  P        G GCT S++LA L  R  +    +Q+ K +
Sbjct: 161 VVGKSIDTLYRKDGSVQNFETPLADPLVIIGAGCTFSSSLACLLARGESLESAIQQGKEY 220

Query: 240 LSSALAQADTLEVG 253
           + +A+       +G
Sbjct: 221 IYNAIITGIDTNLG 234


>UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=1 Tax=Francisella philomiragia
           subsp. philomiragia ATCC 25017 RepID=B0TY65_FRAP2
          Length = 485

 Score =  227 bits (579), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 63/234 (26%), Positives = 124/234 (52%), Gaps = 4/234 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT + +G + C++I+ + AQN+  + ++ ++       Q+ ++  + +I   K  
Sbjct: 19  IQADIKTANNIGVHACTIISCVTAQNSTNILNIEKVSKGIFKEQIQAISKEFKIKVIKTS 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           +L+ T+ ++ V + L   +    + D VM++ +G  L+    V   + +L P  +++ PN
Sbjct: 79  VLSSTEQIDIVVDLLNDLKDVFYICDPVMVSTTGYSLVDYRLVEYSKQKLYPLANILVPN 138

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGH-LDDEQSPDWLFTREGEQR 197
           L EA  LLD   +    E+ E  +++     C +VL+KGGH  D   S D  +T E    
Sbjct: 139 LDEAKMLLDEHDSPNV-EIAEIAKAIQEKYNCKSVLLKGGHDSDKNISLDCYYTPEVNYT 197

Query: 198 FTAPRI-MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTL 250
            T+ R  + +   GTGCT ++A+A+      +  +++  AKS++S+A+  +  +
Sbjct: 198 LTSKRYKLDEKVRGTGCTFASAIASFLTLGFDVNNSIILAKSYISNAIKSSQKI 251


>UniRef50_D1PXN3 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella bergensis DSM
           17361 RepID=D1PXN3_9BACT
          Length = 362

 Score =  227 bits (579), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 74/253 (29%), Positives = 122/253 (48%), Gaps = 4/253 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+I G+D +G +GIQAD+KT SALG Y  + +T +  Q+ +G+  +  +  D V  Q
Sbjct: 5   PYVLSITGSDNTGASGIQADIKTISALGGYALTALTTVTVQDGQGIHDLLNLPCDIVVRQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V       T K+GM+ + D + A+ + +     + +V    +L   G  L+   A+ 
Sbjct: 65  VRAVIEAHHPKTVKVGMVRDADTIAALKDEIVGCPQKVMV--PGILTSHGKQLIGNEAIR 122

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
             +  L+P+ +++     EA  LL +P   ++ EMLE  +   AMG  AVL++GGH  + 
Sbjct: 123 AWKQELIPEATVLLTRCNEAEILLGSP-IVSDDEMLEAAQQFTAMGAQAVLIRGGHQTEG 181

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +    L   E  Q F++        HG G  LSAA+A      +N    +  A  +L S 
Sbjct: 182 RLTAVLMAGEKHQFFSSQNTEGWQRHGVGGALSAAIATHLAMGSNITTAISRAHDYLHSQ 241

Query: 244 LAQADTLEVGHGI 256
           +  A    V  G 
Sbjct: 242 VVYAVDCRV-QGH 253


>UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglomus
           RepID=B5YA99_DICT6
          Length = 263

 Score =  226 bits (578), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 76/255 (29%), Positives = 121/255 (47%), Gaps = 5/255 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             L IAG DPSGGAGI  D K    LG Y   + T L  QNT+ V   Y I P +     
Sbjct: 8   KILVIAGFDPSGGAGILLDTKIIHYLGGYAFCIPTCLTVQNTQKVYKTYEINPKYFLKTF 67

Query: 65  DSVFSDVR-IDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +++  DV   D  KIG L    I++ +   +  Y+++N++LD V+    G PLL   A +
Sbjct: 68  EALIKDVDYFDGVKIGALYSKKIIDLIINLIITYELKNIILDPVINPTKGKPLLKKDAFS 127

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLD- 181
           +L  +L+   S+ITPN+PEA  L      ++  +M      +        +++KGGHL  
Sbjct: 128 SLL-QLISLCSVITPNIPEAEFLSGIK-IKSLDDMEFSLLKIRDKFNIKNIILKGGHLAI 185

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             +  D L+T +    F    +  K+ HGTGC  S+ L     ++ +      E ++  +
Sbjct: 186 GNEVYDLLYTEDKIISFKKEYLKNKHIHGTGCLFSSILTFFLAQNLSIEKAFYETENNFN 245

Query: 242 SALAQADTLEVGHGI 256
             + +A  +  G  +
Sbjct: 246 KFIKRAIKISKGQYV 260


>UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4N3_9GAMM
          Length = 252

 Score =  226 bits (577), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 67/247 (27%), Positives = 118/247 (47%), Gaps = 9/247 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           + L ++G DP GGAGI AD++T +  G     +IT L  QNT+ V+S   ++   +A Q 
Sbjct: 4   SVLVLSGLDPCGGAGIAADIETINQFGVTPLPIITTLTVQNTQSVKSTQEVDSKLIAEQF 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           + + +DV     KIG+L+    +E +   L       +VLD ++ + + D LL    +  
Sbjct: 64  NHLKTDVTFSVAKIGLLSSKKQIEVLTNLLSECDDVTIVLDPIVKSTAKDKLLDSQTLEV 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L+++LLP V +ITPN+ E  AL      + EQ+ +E      ++ C  VL+      +++
Sbjct: 124 LKTKLLPLVDVITPNVDELQALS---PNKNEQQAVE------SLPCEWVLLTTTDSSNDE 174

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
               L+             +  + HG+GCTL++++A L           + A  +    L
Sbjct: 175 IEHRLYHHAELLERYTYTKLPGDYHGSGCTLASSIAGLLALGVETRIACKRALDYTYQTL 234

Query: 245 AQADTLE 251
             A ++ 
Sbjct: 235 LNAKSIG 241


>UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobacter
           RepID=A1TYG7_MARAV
          Length = 253

 Score =  226 bits (576), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 81/249 (32%), Positives = 129/249 (51%), Gaps = 7/249 (2%)

Query: 9   IAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVF 68
           ++G DPSGGAGIQAD++  +++GA+   V+T L  Q+TR V     + PD +  QL+ + 
Sbjct: 2   LSGLDPSGGAGIQADIQAITSIGAHPLPVLTCLTVQDTRNVYGAEPVSPDLIKQQLECLA 61

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSR 128
            D  I   K G L   ++VE + E +Q++    +++D V+ A  G  L   + VA ++ +
Sbjct: 62  QDTPIHAIKTGALGNAEVVEVLVEFVQKHSGVPLIVDPVIKAAGGGDLADDALVAAMKDK 121

Query: 129 LLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDW 188
           L  +  +ITPN  E A L  +          E  R+LL  GC +VL  GGH       + 
Sbjct: 122 LFARAEMITPNGVELAQLGGS------DNPAEAARNLLQTGCESVLATGGHGSGIHIINT 175

Query: 189 LFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
           L+    E   +   R+     HGTGCTL+AA+AA R    +    + +A++++  AL  A
Sbjct: 176 LYNHAPEPMEWEVERVGANEYHGTGCTLAAAIAAGRAMGLSPRAAISQAQNYVHRALLHA 235

Query: 248 DTLEVGHGI 256
            T+  G  +
Sbjct: 236 LTVGQGQKV 244


>UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) n=1
           Tax=Archaeoglobus fulgidus RepID=O28075_ARCFU
          Length = 243

 Score =  226 bits (576), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 16/247 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK I  LTI+G DPSGGAG+ AD+KT  A+G Y  SVIT+L  QNT GV++   +E + +
Sbjct: 1   MKTI--LTISGLDPSGGAGVSADIKTAKAIGLYPASVITSLTVQNTCGVKAAIPVEAEVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL +V  D++ID  KIG++   +I + +A  L        VLD V+ A +G  +    
Sbjct: 59  REQLRAVIEDMKIDCIKIGLITSVEIAKVLAAELVPLNAPK-VLDPVIFAGAGGKIGDEE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A       +L  V ++TPNL EA  LL+     + +E  E    +       V++ GG L
Sbjct: 118 A----YKMILKHVDIVTPNLTEAITLLE-----STKEARELALEMNKKYGCDVVITGGEL 168

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +     +    G     +      N HGTGC  S ALA       +  + V++A+ ++
Sbjct: 169 GGKD----VVCEAGRTYTVSAEFSPVNIHGTGCVYSTALACYLGLGNSLENAVRKARIFV 224

Query: 241 SSALAQA 247
             ++ +A
Sbjct: 225 LESVKKA 231


>UniRef50_C6XZH6 Phosphomethylpyrimidine kinase n=3 Tax=Sphingobacteriales
           RepID=C6XZH6_PEDHD
          Length = 268

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 70/249 (28%), Positives = 110/249 (44%), Gaps = 6/249 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R  A++IAG DPS GAG+ AD+K F     YG  V TAL  Q          ++ + +  
Sbjct: 18  RPYAMSIAGFDPSAGAGLLADVKCFEQHRVYGFGVCTALTVQTDTHFLKNQWLDAEQIIE 77

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSA 121
           Q+  +     +   KIG++  + I+  V   L+++     +VLD V+ A +G        
Sbjct: 78  QMMVLLLKFEVKACKIGLIKNSRILLEVVSHLRQHAPEIKIVLDPVLKASAGYAFHDWEN 137

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
                  +L Q+ LITPN PE  +L     A    ++    +   A     VL+KGGHL+
Sbjct: 138 GLKKLEPVLRQIDLITPNYPEMLSLGGKSGAG---QLTAIAQHWAAYCP--VLLKGGHLE 192

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             +  D+LF            +     HG+GC LSAA+ A   +  +       AK + +
Sbjct: 193 KNKGTDYLFEGSQHFELKTDILSNFQKHGSGCVLSAAITARLAKGDHLLQACISAKKYTA 252

Query: 242 SALAQADTL 250
             L   ++L
Sbjct: 253 HFLNSNNSL 261


>UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7M9W8_BRAFD
          Length = 291

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 97/285 (34%), Positives = 144/285 (50%), Gaps = 23/285 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+    LTIA ++  G  G+QADLKTF+ALGAYG S ++ +       V   Y +  + V
Sbjct: 1   MRPPVVLTIAASESDGAGGLQADLKTFTALGAYGASAVSMIATITAHEVHGTYPLPAEVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ--IQNVVLDTVMLAKSGDPLLS 118
             Q+D+V  D+R+D TKIG L    +V+AVA  ++ ++  +  +VLD VM++  G PL+S
Sbjct: 61  RGQIDAVAGDLRLDATKIGALGSAAVVDAVAAAVRAHRDRLGRIVLDPVMVSAHGAPLIS 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
                 LR +LLP V ++TP + EAA LL  P A + +E+ EQ  +L A G  +VL+ G 
Sbjct: 121 AEGAKALREQLLPLVDVLTPTMAEAAQLLGRPLATSIEEIREQALALQAAGPRSVLVTGR 180

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR------------- 225
            L+ E   D L    G     A R+  +   G G TLSAA+AA   R             
Sbjct: 181 LLEGEDVVDVLVHEGGTDLLRAERVPGRRVRGAGATLSAAIAAQLARIAEFDRAGELGEI 240

Query: 226 -----HTNWADTVQEAKSWLSSALAQADTLEVGH---GIGPVHHF 262
                  +    V  A+ +++SA        +     G GP++H 
Sbjct: 241 GEAGSEDDMVTIVASAREFVASATDNVQDWRLSRRSGGHGPLNHL 285


>UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithiobacillus
           ferrooxidans RepID=B5ERP1_ACIF5
          Length = 277

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 89/251 (35%), Positives = 128/251 (50%), Gaps = 6/251 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+DPS GAG+QADL T ++LG +GC+ +TAL  Q++  V+    ++P    AQ
Sbjct: 13  PVVLTIAGSDPSAGAGLQADLLTLASLGVHGCTAVTALTVQDSVNVRGYTPVDPQDTVAQ 72

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             +V  D+ +   KIGML    +V AV+  L  +    VVLD V+ A  G  L       
Sbjct: 73  ARAVLEDMSVQVIKIGMLGSAAMVAAVSALLADHSQIPVVLDPVLAAGGGMALAGDGLRE 132

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L +RLLP+V+++TPN PEA AL          ++   G  L   G    L+ GGH ++ 
Sbjct: 133 ALVTRLLPRVTVMTPNGPEALALSGT------GDLPAAGVWLNRHGAEWALISGGHGEEP 186

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  + LF  E  +R      +  + HG+GCTL+AALAA         + V  A  +  + 
Sbjct: 187 ELENLLFRGEVLRRTFRQARLPHSYHGSGCTLAAALAAGLAHGLTMEEAVARALDFTHAC 246

Query: 244 LAQADTLEVGH 254
           L  A  L  G 
Sbjct: 247 LVHAYPLGKGQ 257


>UniRef50_A6EM49 Phosphomethylpyrimidine kinase n=1 Tax=unidentified eubacterium
           SCB49 RepID=A6EM49_9BACT
          Length = 246

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 12/250 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           +KR   LTI G DPS GAG+ AD+KTF     YG +V TA   Q      +   I    +
Sbjct: 3   VKRPFVLTIGGFDPSAGAGVLADIKTFEQHKVYGMAVNTANTIQTEDAFFASEAIASTSI 62

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL  +  +      KIG L   +++  VAE  +   ++ ++ D ++ A SG  L    
Sbjct: 63  IKQLRVLTDNYCFKAVKIGWLPSLELINLVAEVFKETSVK-IIWDPILKATSGFDLSHN- 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L  +L   + +ITPN  EA  +        E E++   ++L      A+ +KGGH 
Sbjct: 121 -REQLIEKL-KLIDIITPNWQEARVISG------ETEIISAMQTLSKQ--CAIYLKGGHN 170

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D+LF  + +  +        + HG+GC  S+ALA+      +   +   +K + 
Sbjct: 171 IQAPGRDFLFINQEKVNYKPQGSQVSDKHGSGCVFSSALASNLALGYSLKKSCLNSKQYT 230

Query: 241 SSALAQADTL 250
           ++ L    +L
Sbjct: 231 TALLESNTSL 240


>UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neorickettsia
           RepID=C6V659_NEORI
          Length = 254

 Score =  223 bits (569), Expect = 6e-57,   Method: Composition-based stats.
 Identities = 79/252 (31%), Positives = 126/252 (50%), Gaps = 5/252 (1%)

Query: 1   MKRINALTI-AGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M++I  + I AG+D  GGAG+QADL+  + LG    +V+T + AQ+ +GV ++  +  + 
Sbjct: 1   MRKIPEICIVAGSDSIGGAGLQADLRIAALLGCSASNVVTCITAQDLKGVHAIQYLSGEI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V+ QL    S  +    KIGML  ++I  AV + L+   I  +VLD V+++ S   L   
Sbjct: 61  VSKQLICALS-RKPKAIKIGMLGNSEIALAVYDVLKDTGI-PIVLDPVLISTSNSKLADE 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            AV  L  +LL    L+TPNL EA+ L        E   +     +  +G   VL+KG H
Sbjct: 119 GAVQVLLKKLLSISHLVTPNLFEASTLSGNKVFDAESAKI-AALRIFELGAKNVLVKGIH 177

Query: 180 LDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           + + +  D L ++ G    F    I    THG+GC LS A+A       +  +++  A  
Sbjct: 178 IKEGKIMDLLISQGGATMEFQNEVIRINITHGSGCRLSTAIACHMSMGKSLRESIHFASD 237

Query: 239 WLSSALAQADTL 250
            L + + +   L
Sbjct: 238 LLRNEIIRMGVL 249


>UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobus solfataricus
           RepID=D0KR61_SULS9
          Length = 400

 Score =  223 bits (568), Expect = 7e-57,   Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 119/226 (52%), Gaps = 9/226 (3%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLKTFSALG +G ++IT L AQNTR V  V  I  DF+ AQ D+V  D+     K G
Sbjct: 21  LQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTG 80

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA   +VE V  +++ Y I+ +VLD VM+AKSG  L++      ++ + + +  + TPN
Sbjct: 81  MLASGKVVELVLRKIREYNIK-LVLDPVMVAKSGSLLVTEDISEQIK-KAMKEAIISTPN 138

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
             EA  +++     ++ ++++  R + +   G V++KG         D+      E    
Sbjct: 139 RYEAE-IINKTKINSQDDVIKAAREIYSKY-GNVVVKG-----FNGVDYAIIDGEEIELK 191

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
              I TKNTHG+G   SA++ A         D +  AK + +  + 
Sbjct: 192 GDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVK 237


>UniRef50_C9RIY8 Phosphomethylpyrimidine kinase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RIY8_FIBSS
          Length = 250

 Score =  222 bits (566), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 77/251 (30%), Positives = 130/251 (51%), Gaps = 13/251 (5%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K   ALTIAG D S GAGI AD+KT +  G +  SV TAL  QN     +   +  + + 
Sbjct: 4   KMNFALTIAGFDGSAGAGILADVKTMAHFGVFCESVCTALTQQNEDEFVAPGWVIWERIE 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQ-RYQIQNVVLDTVMLAKSGDPLLSPS 120
           AQL+++F+  +    KIG++ +  +++ + E ++ +     +V D +  A +G   +  +
Sbjct: 64  AQLETLFAKRQFKFVKIGLVEKAKVLQRIVEFVREKSPDAYIVWDPIASASAGFHFMRSA 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCG-AVLMKGGH 179
                   ++ Q+ L+TPNL E   L         ++   +G+     G   A+L+KGGH
Sbjct: 124 ERDEFM-PVMKQIDLVTPNLDEFGFL-------GFEQAASRGK--FEFGKDFALLLKGGH 173

Query: 180 LDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
             D+++ D L+ R+G + +FT+PRI     HGTGC LS+A+ A         ++ Q AK+
Sbjct: 174 STDDEAVDTLWDRDGKQYKFTSPRIPGNGKHGTGCHLSSAILANLALGHTLPESCQIAKN 233

Query: 239 WLSSALAQADT 249
           +L+  L   + 
Sbjct: 234 YLTELLQSGEG 244


>UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI000178943A
          Length = 335

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 83/181 (45%), Positives = 110/181 (60%), Gaps = 1/181 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIAG+D  GGAGIQADLKTF  LG YG S ITA+  QNT GV  VY + P+  A
Sbjct: 5   RIPRALTIAGSDSGGGAGIQADLKTFQELGVYGMSAITAITVQNTMGVHGVYPLPPEATA 64

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+++V SD+ +D  K GML   +I+  VA+R++ +    VV+D VM+AK G  LL   A
Sbjct: 65  EQIEAVGSDLGVDALKTGMLFNAEIIRLVADRIRAFGWGKVVVDPVMIAKGGAELLQSEA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V  LR  LLP   ++TPN+PEA  L      RT  +  E  R +  +G   V++KGGH +
Sbjct: 125 VQALREDLLPLALIVTPNIPEAEVLAGM-RIRTMNDRNEAARRIHDLGPRIVVIKGGHDE 183

Query: 182 D 182
            
Sbjct: 184 G 184



 Score = 98.2 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 2/85 (2%)

Query: 178 GHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           G+ +     D ++           RI T +THGTGCT SAA+ A   +  +  D +Q  +
Sbjct: 242 GNPESPPVIDLVYDGMAFTELYGKRIHTVHTHGTGCTFSAAITAGLAQGLSAYDAIQSGR 301

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++ +A+   D L +G G GP +H+
Sbjct: 302 LFIQAAIE--DGLNLGQGQGPTNHW 324


>UniRef50_Q0FHB8 Phosphomethylpyrimidine kinase ThiD n=2 Tax=Rhodobacteraceae
           RepID=Q0FHB8_9RHOB
          Length = 259

 Score =  221 bits (565), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 91/249 (36%), Positives = 131/249 (52%), Gaps = 11/249 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             L I G D SGGAG+  D  T +A+G   C+ +TA+ AQ+   V+ V  + P  VA+Q+
Sbjct: 4   RVLCIGGIDSSGGAGLLRDAATLAAMGLESCAAVTAVTAQSDAAVREVQVMPPALVASQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +   +  +D  KIGML    +V+AVA  L     + +VLD V+++ SG  LL    +A 
Sbjct: 64  -AAACEGPVDAVKIGMLGHAALVDAVASAL---PDRPLVLDPVLVSTSGRSLLDDDGIAA 119

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDE 183
           L  RL+P+V+L+TPNLPE   L  A  A +E    +    L   GC AVL+KGGH    E
Sbjct: 120 LLGRLVPRVTLMTPNLPELDTLAAALGASSE----KAIGLLQDRGCRAVLVKGGHDATPE 175

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            + DWL+        F APR+      GTGC L++ +A    +H +    VQ AK  L++
Sbjct: 176 VATDWLYRASAPVAEFHAPRLD-GTLRGTGCQLASVIAGGLAQHLDIERAVQNAKHMLTT 234

Query: 243 ALAQADTLE 251
               A  + 
Sbjct: 235 RFRAACDMP 243


>UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella sp. oral taxon
           472 str. F0295 RepID=C9Q178_9BACT
          Length = 368

 Score =  221 bits (563), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 76/242 (31%), Positives = 128/242 (52%), Gaps = 5/242 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTI G+D +GGAGIQAD+KT SALG    S IT++ AQNT G+Q  + +  + V  Q+
Sbjct: 7   PILTINGSDGTGGAGIQADIKTISALGGRALSAITSITAQNTLGIQEFFDLPSETVKGQI 66

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++ +D++    K+GM+   D V  +A  L++++ ++V+ D V+++   + L++   +  
Sbjct: 67  EAIVNDIQPTVVKVGMIRRADTVAQIAHLLRQHKPKHVIYDPVIVSSQNEMLMAQEVIDE 126

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R  LLP  SL+     +A  L       T  ++    +SLLA GC AVL++G H   + 
Sbjct: 127 VRRSLLPLCSLVLMKRADAERLTQTA-INTAADLNLAVKSLLAGGCQAVLLQGSHTPPQS 185

Query: 185 SPDWLFT-REGEQRFTAPRI---MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             D   T ++GE  F             HG   +LSAA+A          + V  A++++
Sbjct: 186 LTDVFATAKDGEPTFLPSLFGEGEGNTRHGLSGSLSAAIATFVNGGNAIFEAVVNARNYI 245

Query: 241 SS 242
           + 
Sbjct: 246 AQ 247


>UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax=Plasmodium
           RepID=B3L660_PLAKH
          Length = 329

 Score =  219 bits (560), Expect = 5e-56,   Method: Composition-based stats.
 Identities = 87/306 (28%), Positives = 137/306 (44%), Gaps = 48/306 (15%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L+IAG+D  GGAGIQAD+KT   LG + C+ +  L AQNT+ V+ +  IE  F+  QL
Sbjct: 6   NILSIAGSDSCGGAGIQADIKTAMGLGCHCCTALVVLTAQNTKEVKRIVEIEEAFIVDQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-----VVLDTVMLAKSGDPLLSP 119
           DS+F+DV ID  K+G+L    I+  V++ + +   +      VV D V ++ SG  L+  
Sbjct: 66  DSIFADVTIDVVKLGVLYSKKIISLVSQYIVQMNKKRGKKLLVVFDPVFVSSSGCLLVEN 125

Query: 120 -SAVATLRSRLLPQVSLITPNLPEAAALLDAPHAR---TEQEMLEQGRSLLAM-GCGAVL 174
              +      + P   +ITPN  E   +L A   +   ++  M E  + +  M    A L
Sbjct: 126 LEYIKFALDLICPISCIITPNFYECKVILQALDCQMDLSKANMTELCKLVTRMLDINACL 185

Query: 175 MKGGHLDDE-------QSPDWLFTR------EGE-----------------------QRF 198
           +K  ++ +         + D L  R      EGE                        + 
Sbjct: 186 LKSCNVGENSAEENEVYAVDHLCIRKVGSIPEGEVIQRDAGELGQSAPGGVTYLYDVYKL 245

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            + R    + HGTGCTLS A+A    +  N   +  E+K ++ + +  A     G     
Sbjct: 246 RSKRKPGVDVHGTGCTLSTAIACYLAKKHNILQSCIESKKYIYNCIRYA--YPFGSKSQG 303

Query: 259 VHHFHA 264
           ++H  A
Sbjct: 304 LNHLKA 309


>UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 Tax=Aciduliprofundum
           boonei T469 RepID=B5IAY3_9EURY
          Length = 242

 Score =  219 bits (559), Expect = 7e-56,   Method: Composition-based stats.
 Identities = 75/245 (30%), Positives = 120/245 (48%), Gaps = 13/245 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DP+ GAG+  D+ TF   G YG  V TAL  QNTRG +    + P+ V  +L +
Sbjct: 5   LSIAGFDPTSGAGVIRDIITFRKFGFYGLGVATALTYQNTRGFKGFKVLSPNVVEQELKA 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D  I   K+GML  +  V+ + E  + +    ++ D ++ AK+G  +     +    
Sbjct: 65  IMGDFPIKFVKVGMLGTS--VDLIVEFAREHDW-FLIFDPLLTAKNGKTINKIEDI---- 117

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL     ITPN+PEA  L      + E +++  G+ L       V++KGGHL+     
Sbjct: 118 EPLLKIAEAITPNVPEAEKLAGIK-IKNESDVISAGKILTHKYGKYVIIKGGHLNG---R 173

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D+LF  +  + +  P+I  K  HGTGC  S++L +   +     +   EA+ +L   +  
Sbjct: 174 DYLF-GDEIKSYGMPKIN-KIVHGTGCAYSSSLLSFIAKGLKIEEAFIEARKFLQREIEN 231

Query: 247 ADTLE 251
           A    
Sbjct: 232 AIDTG 236


>UniRef50_A1ZKW7 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Microscilla marina ATCC 23134 RepID=A1ZKW7_9SPHI
          Length = 250

 Score =  219 bits (558), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 77/247 (31%), Positives = 118/247 (47%), Gaps = 11/247 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +R N L+IAG DPSGGAGI AD+KTF +    G +V T+L  QN    +    +  + + 
Sbjct: 4   ERPNILSIAGFDPSGGAGILADVKTFESHKTLGMAVCTSLTVQNDVAFEKANWVAIEDIK 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPS 120
           AQL ++ +  R    KIG++   D+++ +   L+ +     +V D V+ A +G    S  
Sbjct: 64  AQLVTLGARFRFKVAKIGLVESFDVLQQIVAILREHNPQIKIVCDPVLKASAGFVFHSEV 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A   L   LLP + L+TPN  E   L     A+        G   L+  C  V +KGGH 
Sbjct: 124 AKQQL-EALLPHLFLLTPNWEEVQQLSGVKDAK-------AGAHYLSQFC-HVYLKGGHN 174

Query: 181 DDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +    D+LF+++ +   F   R      HG+GC  S+ALAA              +K +
Sbjct: 175 TEALGKDFLFSQQQKVYAFNPKRTNVAGKHGSGCVFSSALAAHIALQYPLHKACVRSKDY 234

Query: 240 LSSALAQ 246
           ++  LA 
Sbjct: 235 VTRFLAS 241


>UniRef50_C6NTD4 Phosphomethylpyrimidine kinase n=1 Tax=Acidithiobacillus caldus
           ATCC 51756 RepID=C6NTD4_9GAMM
          Length = 267

 Score =  218 bits (557), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 74/231 (32%), Positives = 105/231 (45%), Gaps = 7/231 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IA  DPS GAG+QADL T +ALG + C+ + A   Q++R V  V  +    +AAQ
Sbjct: 5   PLVLSIAAADPSSGAGLQADLLTGAALGVHVCTALAAWTIQDSRDVVRVTALPGTDLAAQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L  + +D      KIG+L   +    VA  L  +    VVLD ++ A  G  +       
Sbjct: 65  LQVLAADCSFSAVKIGLLGSAENARVVARFLDAHPKLPVVLDPILRAGGGRAVSDAELRG 124

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP+ ++ TPN PEA  L          E+    R LLA G   +L+ GGH  D 
Sbjct: 125 VLVDELLPRATVATPNAPEALQLSGC------DELEAAARRLLATGLAHLLISGGHGTDP 178

Query: 184 -QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
            +     +  +G              HGTGCTL+ A+AA         + +
Sbjct: 179 RRIRSRHYRADGVLSCVEQPRRPGQFHGTGCTLATAIAAGLALGRAPDEAI 229


>UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepID=PDXK_TREPA
          Length = 269

 Score =  218 bits (556), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 77/243 (31%), Positives = 117/243 (48%), Gaps = 6/243 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRG--VQSVYRIEPDFVAAQLDSVFSDVRIDTTK 77
           I+ADLKTF   GA+G + +TA+V  +        V+ +E D V  QL++ F+ V +   K
Sbjct: 18  IEADLKTFQEYGAFGVATLTAIVTMDPSRNWSHRVHSLEEDCVRDQLETAFAGVGVSAVK 77

Query: 78  IGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
            GMLA    +E VAE L+R+ +   V D VM+ K     L       +  +LLP+ +++T
Sbjct: 78  SGMLASVHAIECVAEYLERFAVAAYVFDPVMVCKGSGDALHRELNELMIQKLLPRATVVT 137

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK-GGHLDD-EQSPDWLFTREGE 195
           PNL E A +      RT  EM E  R +   G   V +K GG L   + + D  +  +  
Sbjct: 138 PNLFETAQIAGISVPRTVDEMKEGARLIHERGASHVFVKGGGRLPGCKHALDVFYDGKTF 197

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLE--VG 253
                  + +   HG GCT+SAA+ A   R     D +  AK ++++ L     +   VG
Sbjct: 198 HLVEDELVQSGWNHGAGCTVSAAITAGLGRGLTAYDAILSAKRFVTTGLRHGFQVNQWVG 257

Query: 254 HGI 256
            G 
Sbjct: 258 TGN 260


>UniRef50_A4C197 Phosphomethylpyrimidine kinase n=1 Tax=Polaribacter irgensii 23-P
           RepID=A4C197_9FLAO
          Length = 249

 Score =  217 bits (554), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 74/254 (29%), Positives = 116/254 (45%), Gaps = 14/254 (5%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     LTIAG DPS GAGI +D+KTF A G YG S  TA+  QN    +    +E   
Sbjct: 1   MKSAPYILTIAGLDPSSGAGITSDIKTFEAHGVYGLSACTAVTVQNDIAFKECIWMEKHS 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLS 118
           +  Q++++F    +   KIG++   +++ ++ E +++      +VLD V+ A +G    +
Sbjct: 61  ILNQIETLFDRFSVAVVKIGIVQSWEVLHSILETVKKRNPRAKIVLDPVLKASAGFVFHA 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
              +      LL     ITPN  E   L          E + Q           V +KGG
Sbjct: 121 AQDLVVFEKVLL-LCDFITPNYEEIKELFPEKTMEETIEFISQR--------TNVYLKGG 171

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRI--MTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           H   ++  D ++  +   +F  P I     + HG+GC LSAALA+      +   +  +A
Sbjct: 172 HNLAKKGWDEVYHSKT-AKFNIPPIGFTVFDKHGSGCVLSAALASNLALGNSLKKSCLKA 230

Query: 237 KSWLSSALAQADTL 250
           KS+    L    +L
Sbjct: 231 KSYTEQFLNSNSSL 244


>UniRef50_B1MZ30 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Leuconostoc RepID=B1MZ30_LEUCK
          Length = 268

 Score =  216 bits (552), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 81/251 (32%), Positives = 123/251 (49%), Gaps = 6/251 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D   G GIQADL TFS  G +G +V TA+V   T+  Q V+ I P  +A QL
Sbjct: 4   KILTIAGSDSLSGGGIQADLATFSEYGYFGLAVTTAIVTVTTKDFQ-VFPIAPHIIAEQL 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +SV +   I   KIG L     +E VAE LQ  +   +++D VM  K    + +      
Sbjct: 63  NSVLALDDIRAIKIGFLPTVASIEIVAEHLQHIKNIPIIVDPVMAFKETQIVDTHFLAKV 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L  ++LP  +++TPNL EA  L          +M    + +  +G   V++KGG  +   
Sbjct: 123 LTEKILPFATILTPNLKEAEILSG-HDISDVNDMRNAAKEIFQLGPTYVVIKGGSQILGN 181

Query: 184 QSPDWLFTREGEQRFTAPRI-MTKNTH-GTGCTLSAALAALRPRHT-NWADTVQEAKSWL 240
           Q+ D L+       F   +I  ++  H G GC+LSA+LAA   ++       + +AK ++
Sbjct: 182 QAVDVLYDGHQFSLFKQDKIVRSQPYHSGAGCSLSASLAANLSQNNVTVNLALSDAKDFV 241

Query: 241 SSALAQADTLE 251
              +     L 
Sbjct: 242 WQGIKHGVKLN 252


>UniRef50_B4U544 Phosphomethylpyrimidine kinase n=3 Tax=Streptococcus equi
           RepID=B4U544_STREM
          Length = 249

 Score =  215 bits (549), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 79/252 (31%), Positives = 127/252 (50%), Gaps = 5/252 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D   G G+QADL     L ++    IT L + + +G  S++ +  D +
Sbjct: 1   MKN-KVLTIAGSDIFSGGGLQADLAVLHQLDSFAFLAITCLTSCDAKGF-SIHPVATDLL 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A QL S+ + +     K+G+L   +I E VA  L+  +   VVLD V++ K         
Sbjct: 59  AKQLSSLAA-IPFQAIKVGLLPRPEIAEQVALFLELKKDIPVVLDPVLVFKENQDQTVVE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               LRS L P  ++ITPNL EA  L       + ++M+E  + L  MG   V++KGG+ 
Sbjct: 118 MTQALRS-LFPLTAVITPNLREAERLAGLA-INSREQMVEAAKKLYEMGAKRVVIKGGNR 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            D++    LF       F    ++ +  +G GC+ +AA+AA   R  +    V++AK  +
Sbjct: 176 FDQRVALDLFYDAKTLCFLEKPVLARQNNGAGCSFAAAIAAYLARGHSPFRAVEQAKDLV 235

Query: 241 SSALAQADTLEV 252
            +A+ Q++   V
Sbjct: 236 FAAIQQSNDYGV 247


>UniRef50_D0LJB6 Phosphomethylpyrimidine kinase n=1 Tax=Haliangium ochraceum DSM
           14365 RepID=D0LJB6_HALO1
          Length = 292

 Score =  215 bits (548), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 98/211 (46%), Positives = 129/211 (61%), Gaps = 3/211 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R  AL+IAG+D  GGAGIQADL+TFS LG +G + ITA+ AQN  GVQ+V  I  + VAA
Sbjct: 8   RPVALSIAGSDSGGGAGIQADLRTFSRLGVFGTTAITAVTAQNLDGVQAVTGISVELVAA 67

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++VF+   +   K GML   ++VE VA  +    +  VV D VM+A SG  LL   AV
Sbjct: 68  QMEAVFTGFEVGALKTGMLWSAELVERVAAMIDARGVAAVV-DPVMVATSGARLLQEDAV 126

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A  R RL+P  +L+TPNL EAA LL+        E+ +  R+L      AVL+KGGHL+ 
Sbjct: 127 ARYRERLIPGCTLVTPNLDEAAVLLERGPIA-AAELDQVARALGQRFGCAVLLKGGHLEG 185

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGC 213
           +   D L+ R G  R+   RI   NTHG+GC
Sbjct: 186 DP-VDVLWHRGGWTRWRHERIRGVNTHGSGC 215


>UniRef50_C4R5Q7 Multifunctional protein with both hydroxymethylpyrimidine kinase
           and thiaminase activities n=1 Tax=Pichia pastoris GS115
           RepID=C4R5Q7_PICPG
          Length = 553

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 75/273 (27%), Positives = 127/273 (46%), Gaps = 31/273 (11%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+AD+K+ +A G Y  + IT+L AQNT+GV S+   +P F    L++ F D+ ID  K G
Sbjct: 41  IEADIKSITAFGCYALTAITSLTAQNTKGVTSIENTDPKFFEEILEANFEDIEIDVVKTG 100

Query: 80  MLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITP 138
           +L   +    + + L +Y + +  VLD V++A SG  L     +         + ++ITP
Sbjct: 101 LL-NPESSRLLLKFLDKYHKGKPFVLDPVLVATSGSMLADQHELGFTIDSHFKKATIITP 159

Query: 139 NLPEAAAL----------LDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDDEQ--- 184
           N  EA  +           +     T +++    + +     C +VL+KGGH+   +   
Sbjct: 160 NFEEACVIYSYLKKLKTVDELGEIETLEDLKGMAKFIQQTTHCNSVLLKGGHIPWNRNEQ 219

Query: 185 -----------SPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWAD 231
                        D L+    +         + +  THG+GCT++A++AA   R     D
Sbjct: 220 LVKKKGGDPAYITDILYQGHLDKFTVIKTDYLTSSGTHGSGCTIAASIAANIARSLKIED 279

Query: 232 TVQEAKSWLSSALAQADTLEVGHGIGPVHH-FH 263
            V  +  ++  A+  AD   +G G GP++H FH
Sbjct: 280 AVISSIRYVHQAIFGADE-TLGQGKGPLNHVFH 311


>UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosphate diphosphorylase
           n=2 Tax=Shewanella RepID=A1S6Q8_SHEAM
          Length = 525

 Score =  214 bits (546), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 93/279 (33%), Positives = 137/279 (49%), Gaps = 25/279 (8%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +    TIAG+D  GGAGIQADL T   LG YGCSVITA+ AQN+  V +V  + P  + A
Sbjct: 10  KPIVWTIAGSDSGGGAGIQADLLTLQDLGCYGCSVITAITAQNSVAVTAVEPVTPRMLRA 69

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERL-QRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           QL+++ +D+     KIG++A    ++ +A+ L +      V+LD VM+A  G  L SP  
Sbjct: 70  QLETLKADLYPSAVKIGLIANQPQLDFLADWLGENLPGVPVILDPVMVASCGGDLQSPDN 129

Query: 122 VATLR---------SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGA 172
               +         S    ++SLITPN  E + L+       +  +      L     G+
Sbjct: 130 TCPDKTGERSGLDFSPFAGKISLITPNKAELSRLIGRL-LNDDDALEWAANVLWQAFGGS 188

Query: 173 VLMKGGHLDDEQ--SPDWLFTRE----------GEQRFTAPRIMTKNTHGTGCTLSAALA 220
           +L KGG    +Q  + D L   +               +  R+ T + HG+GCTLS+A+A
Sbjct: 189 ILAKGGDCPWQQSKARDLLLLGDIATISPLHRRQGFWLSNERVATVHNHGSGCTLSSAIA 248

Query: 221 ALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           A   +     D V  AK+++   L QA    VG G GP+
Sbjct: 249 AFVAKGLVLPDAVLLAKAYVFEGLRQASA--VGSGPGPL 285


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroi...   329   7e-89
UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria...   326   4e-88
UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenho...   325   9e-88
UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH     322   7e-87
UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionell...   320   2e-86
UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspi...   320   4e-86
UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacte...   317   2e-85
UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquifical...   315   1e-84
UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S...   315   1e-84
UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingoba...   312   7e-84
UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria...   311   1e-83
UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli ...   310   3e-83
UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria...   308   1e-82
UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyr...   307   3e-82
UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   306   5e-82
UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 clu...   306   5e-82
UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   305   7e-82
UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular ...   304   2e-81
UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   301   1e-80
UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular ...   300   2e-80
UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia ...   300   3e-80
UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   300   3e-80
UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria...   299   5e-80
UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomon...   299   8e-80
UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria...   298   1e-79
UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsi...   295   1e-78
UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM      294   2e-78
UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphometh...   293   3e-78
UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroid...   293   4e-78
UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   293   4e-78
UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfati...   293   5e-78
UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular...   292   6e-78
UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokel...   291   2e-77
UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantell...   291   2e-77
UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   290   2e-77
UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   290   3e-77
UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   290   4e-77
UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agarica...   289   5e-77
UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpy...   289   6e-77
UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasma...   288   9e-77
UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinib...   286   4e-76
UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntropho...   286   4e-76
UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Cor...   286   4e-76
UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rh...   286   5e-76
UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   285   8e-76
UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptoco...   285   1e-75
UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria...   284   2e-75
UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   284   2e-75
UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   284   2e-75
UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus ...   284   3e-75
UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   283   3e-75
UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   283   4e-75
UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillal...   283   5e-75
UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanoca...   283   6e-75
UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicute...   282   9e-75
UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q...   282   9e-75
UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteoba...   281   2e-74
UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebact...   280   3e-74
UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria...   280   3e-74
UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobact...   280   3e-74
UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   280   3e-74
UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   279   5e-74
UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_...   279   6e-74
UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Fl...   279   9e-74
UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria ...   278   9e-74
UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamin...   278   1e-73
UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovu...   278   1e-73
UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia d...   277   3e-73
UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobiu...   277   3e-73
UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leo...   276   5e-73
UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular...   275   9e-73
UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicro...   275   9e-73
UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria ...   275   1e-72
UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   273   3e-72
UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpy...   273   3e-72
UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanae...   273   6e-72
UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermopla...   272   1e-71
UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyr...   271   1e-71
UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobac...   270   3e-71
UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobaci...   270   4e-71
UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes...   270   4e-71
UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovi...   269   7e-71
UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetoco...   268   1e-70
UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobacul...   268   2e-70
UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobac...   268   2e-70
UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   267   4e-70
UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprother...   266   4e-70
UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobia...   266   5e-70
UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyri...   266   5e-70
UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholde...   266   7e-70
UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionib...   265   1e-69
UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   265   2e-69
UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Br...   265   2e-69
UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatu...   264   3e-69
UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 ...   263   5e-69
UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   263   6e-69
UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=unculture...   261   1e-68
UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   261   1e-68
UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepI...   261   2e-68
UniRef50_C2CTG3 Multifunctional thiamine-phosphate pyrophosphory...   261   2e-68
UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold...   260   4e-68
UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Ru...   259   6e-68
UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniob...   259   7e-68
UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharop...   258   1e-67
UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kina...   258   2e-67
UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermob...   258   2e-67
UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Ve...   258   2e-67
UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodes...   257   4e-67
UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobac...   256   4e-67
UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   256   6e-67
UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   256   7e-67
UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella...   255   8e-67
UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (H...   255   8e-67
UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium...   255   1e-66
UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bactero...   255   1e-66
UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   255   1e-66
UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   253   4e-66
UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Ta...   253   5e-66
UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   252   7e-66
UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS2...   252   9e-66
UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomy...   252   1e-65
UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phos...   251   1e-65
UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine ar...   250   3e-65
UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioi...   250   4e-65
UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadr...   249   5e-65
UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kan...   249   5e-65
UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosa...   249   6e-65
UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochloro...   249   7e-65
UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovi...   248   2e-64
UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidi...   248   2e-64
UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospir...   247   3e-64
UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria Re...   247   3e-64
UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas...   247   3e-64
UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosp...   246   4e-64
UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanoco...   246   4e-64
UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria ...   246   4e-64
UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular ...   246   5e-64
UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CB...   246   6e-64
UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridi...   245   1e-63
UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   244   2e-63
UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   244   2e-63
UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolob...   244   3e-63
UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   244   3e-63
UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Sac...   243   3e-63
UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Loddero...   243   3e-63
UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   243   5e-63
UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria ...   243   7e-63
UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyri...   242   7e-63
UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobact...   242   1e-62
UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S...   242   1e-62
UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax...   241   1e-62
UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaer...   241   2e-62
UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-...   241   2e-62
UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=...   241   2e-62
UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomo...   241   2e-62
UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosph...   239   6e-62
UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteob...   239   7e-62
UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavisp...   239   8e-62
UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcani...   239   8e-62
UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Mar...   239   9e-62
UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 ...   239   9e-62
UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria ...   238   1e-61
UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   238   1e-61
UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolob...   238   2e-61
UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa...   237   2e-61
UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), Th...   237   3e-61
UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   237   4e-61
UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus ...   235   1e-60
UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) ...   233   3e-60
UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Pro...   233   6e-60
UniRef50_C5A6B1 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Th...   233   7e-60
UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax...   233   7e-60
UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia ...   233   7e-60
UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpy...   232   8e-60
UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptoco...   232   8e-60
UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofu...   231   1e-59
UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphil...   231   2e-59
UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochrom...   231   2e-59
UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma...   230   3e-59
UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   230   3e-59
UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivall...   229   5e-59
UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=...   229   1e-58
UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 ope...   229   1e-58
UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax...   229   1e-58
UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkal...   228   1e-58
UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   228   1e-58
UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Man...   228   1e-58
UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacte...   228   2e-58
UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella ...   227   3e-58
UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta pro...   226   5e-58
UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax...   226   6e-58
UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosac...   225   1e-57
UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonell...   225   1e-57
UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogeno...   224   2e-57
UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   224   2e-57
UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular...   224   2e-57
UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobact...   224   3e-57
UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerot...   223   4e-57
UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Co...   223   4e-57
UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   222   1e-56
UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=...   221   1e-56
UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynt...   221   1e-56
UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosph...   221   1e-56
UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepI...   221   2e-56
UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   219   6e-56
UniRef50_C5RC57 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   219   8e-56
UniRef50_C0X709 Possible phosphomethylpyrimidine kinase n=22 Tax...   219   1e-55
UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) ...   218   1e-55
UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpy...   218   2e-55
UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiob...   218   2e-55
UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=...   218   2e-55
UniRef50_B9E8N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   217   3e-55
UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campyloba...   217   4e-55
UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglo...   217   4e-55
UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomyc...   217   4e-55
UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermans...   216   5e-55
UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q75...   216   7e-55
UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobact...   215   1e-54
UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Br...   215   1e-54
UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospir...   215   2e-54
UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales Re...   214   2e-54
UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   213   5e-54
UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobact...   213   5e-54
UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campyloba...   212   1e-53
UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-ph...   211   1e-53
UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neoricket...   211   2e-53
UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Ge...   211   3e-53
UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybac...   210   4e-53
UniRef50_Q5QUC9 Thiamine monophosphate synthase n=1 Tax=Idiomari...   209   6e-53
UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobac...   209   7e-53
UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobu...   209   8e-53
UniRef50_B0AAH1 Putative uncharacterized protein n=2 Tax=Clostri...   209   9e-53
UniRef50_A6EM49 Phosphomethylpyrimidine kinase n=1 Tax=unidentif...   208   2e-52
UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithio...   208   2e-52
UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosph...   206   4e-52
UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisp...   206   5e-52
UniRef50_C6NTD4 Phosphomethylpyrimidine kinase n=1 Tax=Acidithio...   206   5e-52
UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 T...   206   8e-52
UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotell...   206   8e-52
UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepI...   205   1e-51
UniRef50_C9XPL6 Putative pyridoxine kinase n=6 Tax=Clostridium R...   205   1e-51
UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobac...   205   1e-51
UniRef50_B1MZ30 Hydroxymethylpyrimidine/phosphomethylpyrimidine ...   205   2e-51
UniRef50_A1R2R6 Kinase, pfkB family n=27 Tax=Actinomycetales Rep...   204   2e-51
UniRef50_A1VFK1 Phosphomethylpyrimidine kinase type-1 n=30 Tax=B...   204   2e-51
UniRef50_A4NVQ6 Phosphomethylpyrimidine kinase n=2 Tax=Haemophil...   204   3e-51
UniRef50_Q30XQ8 Pyridoxal kinase, putative n=24 Tax=Bacteria Rep...   203   4e-51
UniRef50_B1ID10 Phosphomethylpyrimidine kinase n=63 Tax=Streptoc...   203   5e-51
UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax...   203   5e-51
UniRef50_B4U544 Phosphomethylpyrimidine kinase n=3 Tax=Streptoco...   203   5e-51

Sequences not found previously or not previously below threshold:

>UniRef50_Q5LCW2 Phosphomethylpyrimidine kinase n=20 Tax=Bacteroides
           RepID=Q5LCW2_BACFN
          Length = 277

 Score =  329 bits (844), Expect = 7e-89,   Method: Composition-based stats.
 Identities = 112/264 (42%), Positives = 157/264 (59%), Gaps = 2/264 (0%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L+IAG+D SGGAGIQAD+KT SALGAY  SVITA+  QNTRGV++V+ +  + 
Sbjct: 1   MKTYPVVLSIAGSDCSGGAGIQADIKTISALGAYAASVITAVTVQNTRGVKAVHTVPAEI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V  Q+++V  D+R D  KIGM++E  +V+ +A  L +Y    +V D VM++ SG  L++ 
Sbjct: 61  VQGQIEAVMEDLRPDALKIGMVSEPALVKIIAGCLLKYPHCPIVYDPVMVSTSGRKLMAK 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  ++  L P  SLITPNL E   L       T +EM E  R L      AVL+KGGH
Sbjct: 121 DAIQLIKEELFPLTSLITPNLDETEVLTG-KKITTAEEMKEAARQLSEEYHTAVLVKGGH 179

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L+  +  D LFT      +   +I ++N HGTGCTLS+++A            V +AKS+
Sbjct: 180 LEGNEMQDVLFTDGNAYIYKEKKIESRNLHGTGCTLSSSIATYLALGLPMDQAVGKAKSY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +S A+     + +GHG GP+ HF 
Sbjct: 240 VSKAIDAGKEIIIGHGNGPLCHFW 263


>UniRef50_B1KWX2 Phosphomethylpyrimidine kinase n=25 Tax=Bacteria RepID=B1KWX2_CLOBM
          Length = 275

 Score =  326 bits (837), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 112/266 (42%), Positives = 173/266 (65%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   L+IAG+D SGGAGIQADLKTFSA G +G SVI ++VA+NT  V  +  + PD +
Sbjct: 1   MKK--VLSIAGSDCSGGAGIQADLKTFSAHGVFGMSVIVSVVAENTSRVIDIQDVTPDMI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+D+V+ D+  D  KIGML+  D ++AV+E+LQ Y+ +N+V+D VM AK+G PL+ P+
Sbjct: 59  KSQIDAVYEDIGTDAVKIGMLSTPDCMKAVSEKLQEYKPKNIVIDPVMYAKNGCPLMDPN 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           +V+TL   ++    ++TPN+PEA  +      +T ++M +    +  MGC +VL+KGGH 
Sbjct: 119 SVSTLIESIVYHADILTPNIPEAERISGYK-IKTLEDMEKAAGIIEGMGCKSVLIKGGHY 177

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             + + D L+       +   RI TKNTHGTGCTLS+A+A+         + V+ AK+++
Sbjct: 178 IGD-AVDVLYDGNKFYHYKTQRIHTKNTHGTGCTLSSAIASNLALGFEINEAVKRAKNYI 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           + A+  +  LE+G G GP +HF+  +
Sbjct: 237 TMAIEHS--LEIGKGNGPTNHFYQVY 260


>UniRef50_A3XJN4 Phosphomethylpyrimidine kinase n=1 Tax=Leeuwenhoekiella blandensis
           MED217 RepID=A3XJN4_9FLAO
          Length = 277

 Score =  325 bits (834), Expect = 9e-88,   Method: Composition-based stats.
 Identities = 107/268 (39%), Positives = 157/268 (58%), Gaps = 5/268 (1%)

Query: 1   MKR---INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK+      L+IAG D SGGAGIQADLKT SALG Y  +V+TAL  QNT GVQS++ I  
Sbjct: 1   MKKYQYPTVLSIAGFDGSGGAGIQADLKTISALGCYATTVLTALPVQNTTGVQSIFSIPT 60

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
             V  QLDS+F D++    KIGM+   ++VE +A +L+ Y    VV D VM+A SG  L+
Sbjct: 61  SVVKEQLDSIFDDIQPSAIKIGMVHTPELVETIAAKLKNYPKIPVVFDPVMVATSGHKLI 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
               + ++   L P   +ITPN+ EAA L   P   T ++M   G  +L + C +VL+KG
Sbjct: 121 EDETIKSITELLFPLADVITPNMDEAAILAQMP-VETIEDMRIAGNKILDLSCKSVLLKG 179

Query: 178 GHLDDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GHL  +      F  +     F   +  T+N HG+GCTLS+A+A+   +  +  ++V +A
Sbjct: 180 GHLKSDLLTSLFFGPDKTVDEFEFEKFETQNMHGSGCTLSSAIASFLAQKNSLLNSVTKA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHA 264
           + ++  A+  A  +++G G GP++HF  
Sbjct: 240 QEYVHQAIYHAKEVKIGKGNGPLNHFFN 267


>UniRef50_Q5M731 At1g22940 n=14 Tax=Embryophyta RepID=Q5M731_ARATH
          Length = 522

 Score =  322 bits (827), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 117/266 (43%), Positives = 159/266 (59%), Gaps = 2/266 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LT+AG+D   GAGIQADLK  +A G Y  SVITA+ AQNTRGVQSV+ + P+F++
Sbjct: 29  KVPQVLTVAGSDSGAGAGIQADLKVCAARGVYCASVITAVTAQNTRGVQSVHLLPPEFIS 88

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL SV SD   D  K GML  T+IVE + + L  + ++ +V+D VM++ SG  L   S 
Sbjct: 89  EQLKSVLSDFEFDVVKTGMLPSTEIVEVLLQNLSDFPVRALVVDPVMVSTSGHVLAGSSI 148

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           ++  R RLLP   +ITPN+ EA+ALLD     T  EM    +SL  MG   VL+KGG L 
Sbjct: 149 LSIFRERLLPIADIITPNVKEASALLDGFRIETVAEMRSAAKSLHEMGPRFVLVKGGDLP 208

Query: 182 D-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D   S D  F  +      +PRI T+NTHGTGCTL++ +AA   + ++    V+ AK ++
Sbjct: 209 DSSDSVDVYFDGKEFHELRSPRIATRNTHGTGCTLASCIAAELAKGSSMLSAVKVAKRFV 268

Query: 241 SSALAQADTLEVGHG-IGPVHHFHAW 265
            +AL  +  + +G G  GP  HF   
Sbjct: 269 DNALDYSKDIVIGSGMQGPFDHFFGL 294


>UniRef50_C6MZJ4 Phosphomethylpyrimidine kinase n=2 Tax=Legionella
           RepID=C6MZJ4_9GAMM
          Length = 273

 Score =  320 bits (822), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 129/262 (49%), Positives = 169/262 (64%), Gaps = 3/262 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG D SGGAGIQADLKTFSA G YG +V+TAL  QNT GV++ Y I    +  QL +
Sbjct: 6   LSIAGFDGSGGAGIQADLKTFSAFGCYGMTVLTALPVQNTCGVRNCYDIPLQAIDDQLHA 65

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +F D+R D  KIGML  ++I+E VA  L+++ +   ++LD V +AKSGDPLL P AV TL
Sbjct: 66  IFDDIRPDGIKIGMLFNSEIIELVAAFLKKHARDIPIILDPVTVAKSGDPLLLPEAVDTL 125

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            ++L+P  +LITPNLPEA        A++E+EML   + LL +G   VL+KGGHL    S
Sbjct: 126 ITKLMPLATLITPNLPEAHTFTGVD-AQSEEEMLVVAQKLLDLGPQYVLLKGGHLLASTS 184

Query: 186 PDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
            D L  + G    F +PRI +KNTHGTGCTLSAA+ A   ++       + AK +L +A+
Sbjct: 185 NDLLIGKNGTRHWFESPRIESKNTHGTGCTLSAAITACLAQNVEIEKACEIAKRYLFNAI 244

Query: 245 AQADTLEVGHGIGPVHHFHAWW 266
             A    VG G GPVHHF+  W
Sbjct: 245 KAAKDNSVGKGHGPVHHFYHLW 266


>UniRef50_C0R0V9 Phosphomethylpyrimidine kinase n=2 Tax=Brachyspira
           RepID=C0R0V9_BRAHW
          Length = 269

 Score =  320 bits (820), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 123/263 (46%), Positives = 165/263 (62%), Gaps = 2/263 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG D SGGAGIQADLKTFSALG YG  V+TAL  QNT+GV+S Y IE   +  QL
Sbjct: 3   KALTIAGFDGSGGAGIQADLKTFSALGCYGMCVLTALPVQNTQGVRSCYEIELKAIKEQL 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +F D+  D  KIGML  +DI++ VA+ L    +   +++D VM+AKSGD LL   AV 
Sbjct: 63  ECIFDDIIPDAIKIGMLFNSDIIKLVADFLSNNAKNIPIIVDPVMVAKSGDRLLLEEAVD 122

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           +L+  +LP  +++TPN+PEA  L      +T+ +M++    +L MG   V++KGGHL+ E
Sbjct: 123 SLKKYILPISTVVTPNIPEAEDLTS-KKIKTDDDMIDAANDILNMGAKNVMLKGGHLEGE 181

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            S D    +E ++   A RI TKNTHGTGCTLSAA+ +         +  +  K +L +A
Sbjct: 182 LSRDLFINKESKEFLDALRIDTKNTHGTGCTLSAAICSYIAHGKTPLEASKLGKQYLFNA 241

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           L  A    VG G GPVHHF+  W
Sbjct: 242 LQAAKVDSVGKGHGPVHHFYEAW 264


>UniRef50_C0EZ09 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0EZ09_9FIRM
          Length = 483

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 106/272 (38%), Positives = 155/272 (56%), Gaps = 13/272 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D SGGAGIQAD+KT +    Y  + ITAL AQNT G+  +  +  +F 
Sbjct: 218 MK--TVLTIAGSDSSGGAGIQADIKTLTVHKVYAMTCITALTAQNTVGITGIMPVPAEFF 275

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++S+F+D++ D  KIGM+A  +  E +AE L++Y I+NVV D VM++ SG  L+  +
Sbjct: 276 KKQMESIFTDIKPDAVKIGMIASKEQAEIIAEYLEKYSIKNVVADPVMISTSGTVLVEET 335

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L  +L P+VSL+TPN+PE   L        ++   E  + +      AVL KGGH 
Sbjct: 336 TRKILYEKLYPKVSLLTPNIPETEFLSGIK-ITDKKTREEAAKVIADRWNCAVLSKGGHS 394

Query: 181 DDEQSPDWLFT-------REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
           + E + D L+        +E    F   RI   NTHGTGCTLS+A+AA   +     ++V
Sbjct: 395 E-ENADDLLYESFLQEEKKEKAVWFPEERIDNPNTHGTGCTLSSAVAANLAKGFPVEESV 453

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           ++AK ++S A+     L +G G GP++H    
Sbjct: 454 KKAKVYISGAIRAM--LNLGQGNGPLNHMWDL 483


>UniRef50_C0QRY4 Phosphomethylpyrimidine kinase n=2 Tax=Aquificales
           RepID=C0QRY4_PERMH
          Length = 262

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 101/262 (38%), Positives = 152/262 (58%), Gaps = 5/262 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            AL+IAG+D SGGAGIQADLK FSA G YG S +T++  QNT GV+  + +  D +  Q+
Sbjct: 4   KALSIAGSDNSGGAGIQADLKVFSAFGVYGMSAVTSVTVQNTLGVKGSHPVPSDILFEQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D+ +D  K GML   + V AV + ++  +++N V DTV+ +K+G  LL  SA+ T
Sbjct: 64  KAVVEDIGVDAFKTGMLQTEENVLAVYQAVKDLRMKNFVADTVIRSKNGKYLLDKSAIET 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-DE 183
              R++P   +ITPN+ EA  L      R+  +M+   + L  MG  AV++KGGHL   +
Sbjct: 124 FIKRIVPLADIITPNIDEAEVLTGI-EIRSVDDMIRAAKELYRMGSSAVVVKGGHLPQGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D  +  +       P + TKNTHGTGCT SAA+ A   +  +    V+ A+S++  A
Sbjct: 183 RIVDIFYNGD-LYTLEYPYVRTKNTHGTGCTFSAAITACLAKGYDHLKAVRVARSYIQGA 241

Query: 244 LAQADTLEVGHGIGPVHHFHAW 265
           +  +  L +G G G ++HF   
Sbjct: 242 IENS--LSIGKGTGSLNHFWTV 261


>UniRef50_B0D2S3 Predicted protein n=2 Tax=Agaricales RepID=B0D2S3_LACBS
          Length = 511

 Score =  315 bits (807), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 112/282 (39%), Positives = 155/282 (54%), Gaps = 24/282 (8%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAG+D SGGAGIQADLKTF+A G YG SVITAL AQNT+GV  V+   P+FVA Q+ 
Sbjct: 9   VLTIAGSDSSGGAGIQADLKTFAAHGCYGASVITALTAQNTQGVHGVHPCPPEFVAQQIH 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRY----QIQNVVLDTVMLAKSGDPLLSPSA 121
           SV  D+ I+  K GML + +  + V + L+ +     +  ++ D V ++ SG  LL P A
Sbjct: 69  SVLEDLEINAIKTGMLYDVENTKQVVKSLKAHYKNKALPPLICDPVCVSTSGHTLLHPEA 128

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAP----HARTEQEMLEQGRSLLAMGCGAVLMKG 177
           V  L   L P  +LITPN  EA  LL +        + ++ML     LL+ GC AVL+KG
Sbjct: 129 VEILIDELFPLATLITPNKAEAELLLSSRNPFVDITSLEDMLSATEQLLSFGCAAVLLKG 188

Query: 178 GHL-------------DDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALR 223
           GH+               E   D L+   G++  F  PRI + +THGTGCTLS+A+A   
Sbjct: 189 GHITSTMTDTGINVADHPELVVDVLYQSNGKKSLFVMPRIESTSTHGTGCTLSSAIACEL 248

Query: 224 PRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
               +  +  + A  +    +  A    +G G GP++H H+ 
Sbjct: 249 ACGLSLEEATKNAAIFTHMGIEAAH--PMGKGHGPLNHLHSL 288


>UniRef50_C2FVP8 Phosphomethylpyrimidine kinase n=2 Tax=Sphingobacterium
           spiritivorum RepID=C2FVP8_9SPHI
          Length = 278

 Score =  312 bits (801), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 107/262 (40%), Positives = 155/262 (59%), Gaps = 2/262 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           I  L+IAG D SGGAGIQAD+KTFSALG Y  SV+TAL  QNT+GV+S+Y I    V  Q
Sbjct: 8   IPVLSIAGFDGSGGAGIQADMKTFSALGCYATSVLTALPVQNTQGVRSIYPIPDVAVREQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + ++  D+     KIGM+  +++V+ + + L  Y    VV D VM+A SG  L+  S + 
Sbjct: 68  IQTILDDIFPKAIKIGMVHTSELVQIITDTLGLYPATPVVFDPVMVATSGHKLIEESTIL 127

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           TL  +L P  +++TPN+ EAA L +    +T  +M   G  +L +GC +VL+KGGHL   
Sbjct: 128 TLVEQLFPITTVLTPNMDEAAILAEM-EVKTLDDMYIAGEKILKLGCQSVLLKGGHLQTS 186

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
                 F + G  Q F   +  T NTHG+GCTLS+A+A+   R  + AD V+  + ++  
Sbjct: 187 MLTSLFFDQSGSVQTFEFEKFETNNTHGSGCTLSSAIASYLARGESLADAVRLGQDYVHQ 246

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+     ++ G G GP++HF  
Sbjct: 247 AILNGKDVQTGKGNGPLNHFFN 268


>UniRef50_A1W069 Phosphomethylpyrimidine kinase n=20 Tax=Bacteria RepID=A1W069_CAMJJ
          Length = 270

 Score =  311 bits (798), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 108/270 (40%), Positives = 159/270 (58%), Gaps = 9/270 (3%)

Query: 1   MK-----RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRI 55
           MK      I  LTIAG+D SGGAGIQADLKTFSA   +G SV+ ++VA+NT  V SV+ I
Sbjct: 1   MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDI 60

Query: 56  EPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDP 115
               V  Q+ +VF D+    TKIGM+   +++  VA+ L  ++ QNVV+D VM AK+G  
Sbjct: 61  PTQSVDEQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYA 120

Query: 116 LLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           L+        +  ++    ++TPN+PEA  L        E++M++  + L ++G  AVL+
Sbjct: 121 LMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFK-IANEEQMIKAAKHLCSLGAKAVLL 179

Query: 176 KGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           KGGH + E + D L+  +        RI TKNTHGTGCTLS+A+A+   +  +    V E
Sbjct: 180 KGGHSE-ENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFYAVSE 238

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           AK ++ +A+  +  L +G G GP +HF  +
Sbjct: 239 AKEYVRNAIYYS--LNLGKGCGPTNHFFKF 266


>UniRef50_Q5HMC8 Phosphomethylpyrimidine kinase n=13 Tax=Bacilli RepID=Q5HMC8_STAEQ
          Length = 273

 Score =  310 bits (796), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 108/266 (40%), Positives = 155/266 (58%), Gaps = 6/266 (2%)

Query: 1   MKRINA-LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M +    LTIAGTDP+GGAG+ ADLK+F A G YG + IT++VAQNT GVQ ++ +E  +
Sbjct: 1   MNKPKIALTIAGTDPTGGAGVMADLKSFHACGVYGMATITSIVAQNTLGVQHIHNLESSW 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V  QLDSVF D      K GM+A    +E +   L+ +     V+D VMLAKSGD L+  
Sbjct: 61  VKEQLDSVFDDELPQAIKTGMIATKKTMELIQSYLKEHSNIPYVIDPVMLAKSGDSLMDE 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRS-LLAMGCGAVLMKGG 178
           +    L+S LLP   ++TPN+PEA  +        E+ + + G+  +  +G   V++KGG
Sbjct: 121 NTKNHLQSTLLPLADVVTPNIPEAEEITGIK-INDEESIRKAGQIFINEIGSKGVVIKGG 179

Query: 179 HLDD-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H  D   + D+LFT+     F   R  TK+THGTGCT SA + A   +  +  D V++AK
Sbjct: 180 HSADLNNAKDFLFTKNETYTFENKRFDTKHTHGTGCTFSAVITAELAKGRSIKDAVKKAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFH 263
            ++S ++       +G G GPV+HF 
Sbjct: 240 EFISLSIEHTPE--IGKGRGPVNHFA 263


>UniRef50_B0KBA9 Phosphomethylpyrimidine kinase n=31 Tax=Bacteria RepID=B0KBA9_THEP3
          Length = 264

 Score =  308 bits (790), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 102/246 (41%), Positives = 153/246 (62%), Gaps = 4/246 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTFSA G YG SVIT++ AQNT GV  +  I PD V  Q+ ++F D+  D  KIG
Sbjct: 18  IQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMKAIFEDLYPDAVKIG 77

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           M++   I++ +A+ L+ Y ++N+VLD VM++KSG  LL P AV  L+  L+P   ++TPN
Sbjct: 78  MVSNESIIKMIAKGLKDYNVKNIVLDPVMISKSGSYLLKPEAVEALKKELIPLSLVVTPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L EA  L+     +   +M E  + +L  G   V++KGGHL  + + D  +  +     T
Sbjct: 138 LMEAGELIG-KEIKNVSDMKEAAKKILDYGAKTVIVKGGHLTGD-ALDVFYDGKEFYEIT 195

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + RI TKNTHGTGCT S+A+AA      +  ++++ AK++++ A+  +  L +GHG+GP 
Sbjct: 196 SERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAIKHS--LAIGHGVGPT 253

Query: 260 HHFHAW 265
           +HF   
Sbjct: 254 NHFWNI 259


>UniRef50_Q0I130 Phosphomethylpyrimidine kinase (Hydroxymethylpyrimidine
           phosphokinase) n=3 Tax=Pasteurellaceae
           RepID=Q0I130_HAES1
          Length = 270

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 117/265 (44%), Positives = 160/265 (60%), Gaps = 6/265 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K   ALTIAG+D SGGAGIQADLKTF     +G + ITA+ AQN+ GV  ++ + P  + 
Sbjct: 3   KVAIALTIAGSDNSGGAGIQADLKTFQMQKVFGMTAITAVTAQNSLGVYDIHPVPPATIR 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           +QL ++  D ++   KIGML   DI++ VAE L++Y    +VLD VM AK G  LL P+A
Sbjct: 63  SQLKAIAEDYQVSALKIGMLGNVDIIQCVAEELEKYDFGKIVLDPVMYAKGGAALLEPAA 122

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V+TLRS LLP+  +ITPNLPE AAL D          L     LL MG   V++KGGH  
Sbjct: 123 VSTLRSLLLPKTDVITPNLPEVAALTDIHVVDDHTARL-AAEKLLVMGVKNVVIKGGHSQ 181

Query: 182 D---EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           +   E   DWLFT+    +  +PR  T +THGTGCT SA + A   +  +    V+ AK 
Sbjct: 182 NSQSEICRDWLFTQHSSLKLDSPRFDTPHTHGTGCTFSACIVAELAKGESVQSAVRTAKD 241

Query: 239 WLSSALAQADTLEVGHGIGPVHHFH 263
           ++S++++    L +GHG GP +H+ 
Sbjct: 242 FISASISH--PLNIGHGHGPTNHWA 264


>UniRef50_B7GEW3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Bacteria RepID=B7GEW3_ANOFW
          Length = 293

 Score =  306 bits (785), Expect = 5e-82,   Method: Composition-based stats.
 Identities = 98/244 (40%), Positives = 144/244 (59%), Gaps = 3/244 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF  L  +G S ITA+ AQNT GVQ VY +  + +  Q+DS+  D+  +  K G
Sbjct: 50  IQADLKTFHQLHVFGMSAITAVTAQNTLGVQGVYPLPIEAIEKQIDSIAIDLPPNAVKTG 109

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA ++++Y    VV+D VM+AK G PLL   AV  L+  +LP   ++TPN
Sbjct: 110 MLFSEEIIELVARKIKQYGWVRVVVDPVMIAKGGAPLLKQEAVKALQRHMLPLARVLTPN 169

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L +     T ++  E  + L  MG   V+MKGGH + E+  D L+  E    + 
Sbjct: 170 IPEAEVLTNMR-IETFEQRKEAAKKLHDMGVQYVVMKGGHGEGEELVDLLYDGEQFYEWK 228

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           + R+ TK+THGTGCT +AA+ A   +     + V  AK ++ +A+ Q   L++G G GP 
Sbjct: 229 SRRVHTKHTHGTGCTFAAAITAELAKGKTVYEAVNIAKQFIQAAIEQT--LQIGGGHGPT 286

Query: 260 HHFH 263
           +H+ 
Sbjct: 287 NHWA 290


>UniRef50_Q1V215 Phosphomethylpyrimidine kinase n=4 Tax=SAR11 cluster
           RepID=Q1V215_PELUB
          Length = 270

 Score =  306 bits (785), Expect = 5e-82,   Method: Composition-based stats.
 Identities = 99/266 (37%), Positives = 156/266 (58%), Gaps = 4/266 (1%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L IAG+D SGGAGIQAD+KT +ALG+Y  + ITA+  QNT GV+S+  I+P  
Sbjct: 1   MKPKSKILVIAGSDSSGGAGIQADIKTITALGSYAMTAITAVTIQNTTGVKSIVPIDPKE 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           ++ Q++    D++ D  KIGML  T ++++V   L   +++ ++LD VM+AK G  L+  
Sbjct: 61  ISNQIEFTSKDIKPDAIKIGMLHSTKVIKSVIHSLNLIKVKKIILDPVMVAKGGAKLIDD 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  L++ L+ +VSLITPN+PEA  L      RT+++M+     L+ +G   V +KGGH
Sbjct: 121 KAIQLLKNELIKKVSLITPNIPEAEILTKTK-IRTKEDMIFAASILIKLGAKNVFIKGGH 179

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L+ +   D    +         RI T+NTHGTGCTLS+A++           + + A  +
Sbjct: 180 LESKIVQDIFVNKNEIFIIKNKRITTRNTHGTGCTLSSAISTFFSCGKTLKRSCELATKY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           + +++     L+ G G GP++H  + 
Sbjct: 240 VHNSI--NSNLKFGKGHGPINHLSSV 263


>UniRef50_C5VH24 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella melaninogenica
           ATCC 25845 RepID=C5VH24_9BACT
          Length = 271

 Score =  305 bits (783), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 117/265 (44%), Positives = 166/265 (62%), Gaps = 2/265 (0%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+ I ALTIAG+D SGGAGIQAD+KT SALG Y  +VIT++  QNT+GVQ+VY + P  V
Sbjct: 1   MRYICALTIAGSDCSGGAGIQADIKTMSALGVYAAAVITSITVQNTKGVQAVYGMNPLIV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A Q+ +V  D++ D  KIGM+ +   + A+A+ L+ Y    +V+D +M++ SG  L+   
Sbjct: 61  ADQIKAVMDDIKPDAVKIGMVNDCATIHAIADTLKFYPNIPIVIDPIMISTSGFRLMKQD 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +      LLP  +L+TPNLPEA  L +     T  +M    + +L++GC AVL+KGGH 
Sbjct: 121 TLELFCHSLLPMSTLLTPNLPEAEILSNMK-IYTIDDMDIAAQRILSLGCKAVLIKGGHA 179

Query: 181 DDEQSPDWLFT-REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             ++  D L+T  EG Q FT   I T+NTHGTGCTLS+A+ +   R  + AD +  AK++
Sbjct: 180 KGDRKVDRLYTTNEGVQTFTHKTIDTRNTHGTGCTLSSAITSFIARRLDLADAIAAAKNY 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFHA 264
           LS AL     + +G G GPV+H   
Sbjct: 240 LSQALEAGKDIHIGEGHGPVNHLFN 264


>UniRef50_A8MBV4 Phosphomethylpyrimidine kinase n=4 Tax=cellular organisms
           RepID=A8MBV4_CALMQ
          Length = 436

 Score =  304 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 111/264 (42%), Positives = 162/264 (61%), Gaps = 7/264 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K   ALTIAG D  GGAGI ADLKTF A+G YG   +TA+ AQNT GV++V  IEP  V 
Sbjct: 4   KLPKALTIAGLDSGGGAGITADLKTFHAMGVYGMVALTAVTAQNTLGVKAVQEIEPSIVE 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+++V  D+ +D  K GML+ + I+E+VA+ ++R+    +V+D VM AKSGDPL+   A
Sbjct: 64  AQINAVAEDIGVDAAKTGMLSSSPIMESVAKVVRRWGF-PLVVDPVMYAKSGDPLMRQDA 122

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHL 180
           + TLR  ++P   ++TPN+PEA AL      R   +     + +        V++KGGHL
Sbjct: 123 IDTLRRTIIPLAKVVTPNIPEAEALSGV-SIRNLNDAKAAAKRIAEEFHPEIVIVKGGHL 181

Query: 181 DDEQSPDWLF--TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
              +S D ++       +  +APRI T NTHGTGC+ SAA+AA   +  +  D++++AK 
Sbjct: 182 TGAESIDVVYFRDNGEYRELSAPRISTGNTHGTGCSFSAAIAAGLAKGMSPWDSIKQAKE 241

Query: 239 WLSSALAQADTLEVGHGIGPVHHF 262
            ++ A+  +  L +GHG GPV+  
Sbjct: 242 LITMAIQYS--LPLGHGHGPVNPM 263


>UniRef50_Q6G7L7 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=85
           Tax=Bacilli RepID=THID_STAAS
          Length = 276

 Score =  301 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 110/268 (41%), Positives = 160/268 (59%), Gaps = 6/268 (2%)

Query: 1   MKRINA-LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M +    LTIAGTDP+GGAG+ ADLK+F + G YG  V+T++VAQNT GVQ ++ +   +
Sbjct: 1   MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQHIHNLNHQW 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V  QLDSVF+D      K GM+A  D +E +   L +++    V+D VMLAKSGD L+  
Sbjct: 61  VDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDN 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRS-LLAMGCGAVLMKGG 178
                L+  LLP   ++TPNLPEA  +       +E+++++ GR  +  +G   V++KGG
Sbjct: 121 DTKQNLQHTLLPLADVVTPNLPEAEEITGLT-IDSEEKIMQAGRIFINEIGSKGVIIKGG 179

Query: 179 HLDD-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H +D + + D+LFT EG Q F   R  TK+THGTGCT SA + A   +     + V +AK
Sbjct: 180 HSNDTDIAKDYLFTNEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRRLFEAVHKAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAW 265
            ++S ++       +G G GPV+HF   
Sbjct: 240 KFISMSIQYTPE--IGRGRGPVNHFAYL 265


>UniRef50_A1K3Q3 Phosphomethylpyrimidine kinase n=9 Tax=cellular organisms
           RepID=A1K3Q3_AZOSB
          Length = 284

 Score =  300 bits (770), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 135/271 (49%), Positives = 170/271 (62%), Gaps = 8/271 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
            N L+IAG DPSGGAGI AD+KTFSALGAYGC VI AL AQNT+ V  V+    DF+  Q
Sbjct: 12  PNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD++F+DV +  TKIGML   ++   VA+RL  +Q  NVVLD VM+AKSGD LL+ +A+A
Sbjct: 72  LDTLFADVAVHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIA 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGC----GAVLMKGGH 179
            +R  L PQ  +ITPNLPEA  LL+     + +EM      L  +        V++KGGH
Sbjct: 132 MMREALFPQSFMITPNLPEAGVLLEQRAPESVKEMYRAAERLRELLPLSSERWVMLKGGH 191

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALR---PRHT-NWADTVQE 235
           L   +  D LF  +      APRI T+NTHGTGCTLS+A+AAL              V++
Sbjct: 192 LPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAGGFRGVEAAVRQ 251

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           A+ WL  A+A +  L VG G GPVHHFHA W
Sbjct: 252 ARQWLLGAIAHSGDLGVGSGHGPVHHFHALW 282


>UniRef50_Q8D2N6 ThiD protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2N6_WIGBR
          Length = 272

 Score =  300 bits (769), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 132/268 (49%), Positives = 198/268 (73%), Gaps = 2/268 (0%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK+I   L+IAGTDP+ GAGIQ DLKTFSALGAYG +VIT+LV+QNT+GVQS+Y++  + 
Sbjct: 1   MKKIYKILSIAGTDPTCGAGIQCDLKTFSALGAYGLTVITSLVSQNTKGVQSIYKLPINV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           + +Q++SVFSDV+ID+ KIGML ++ I+E + + +++Y I  ++LD VM +K G  LL  
Sbjct: 61  IKSQINSVFSDVKIDSIKIGMLYDSAIIETIYKEIKKYYIPWIILDPVMSSKDGSCLLKK 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            ++  ++  L P  S++TPNL E++ +L+   A+ E ++ EQG+++L  GC  VLMKGGH
Sbjct: 121 RSINKIKKLLFPISSIVTPNLKESSLILNCSIAKNESQLKEQGKAILEYGCNMVLMKGGH 180

Query: 180 LDDE-QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L +  +S DWL ++  E +F   RI TKNTHGTGC+LS+A+AAL P+  NW +T++++KS
Sbjct: 181 LKNNKESSDWLISKNKEIKFKGVRINTKNTHGTGCSLSSAIAALMPKFCNWEETIKKSKS 240

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAWW 266
           WL  ++ +++ L +G GIGP+HHF+  W
Sbjct: 241 WLEMSIYKSNKLNIGKGIGPIHHFYNLW 268


>UniRef50_A6LAW4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=5
           Tax=Bacteroidales RepID=A6LAW4_PARD8
          Length = 282

 Score =  300 bits (769), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 108/264 (40%), Positives = 161/264 (60%), Gaps = 2/264 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIAG+D  GGAGIQAD+KTFS+LG +G S ITA+ AQNT+GV+ +  I P+ + 
Sbjct: 8   RYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILR 67

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q++++  D  +D  KIGML   D V+ V+E L  ++  +++LD VM++ SG  LL   A
Sbjct: 68  GQIEAILEDFIVDAVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDA 127

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           + T+   L P+ +L+TPN+PE   L        E ++L   R L   GC A+L+KGGH+ 
Sbjct: 128 IRTIMDELFPKATLLTPNIPETEYLSGIK-INNEADILCAARKLQEKGCNAILIKGGHIP 186

Query: 182 DEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             ++ D LF          +P + T NTHGTGCTLS+A+AA      +  + V+ AK ++
Sbjct: 187 GVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVRLAKEYM 246

Query: 241 SSALAQADTLEVGHGIGPVHHFHA 264
           ++AL     + +G G GPV+HF +
Sbjct: 247 NNALVHGANVCMGKGHGPVNHFFS 270


>UniRef50_A7I3E2 Phosphomethylpyrimidine kinase n=14 Tax=Bacteria RepID=A7I3E2_CAMHC
          Length = 257

 Score =  299 bits (767), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 107/263 (40%), Positives = 157/263 (59%), Gaps = 7/263 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
            I  LTIAG+D SGGAGI+AD+KTF A G YG SVIT++VA+NT  V + Y +    V  
Sbjct: 1   MIPVLTIAGSDASGGAGIEADIKTFCAHGLYGMSVITSVVAENTFRVINAYDMSAQAVGD 60

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++VF D+     KIGML   +I++ VAE+L ++  +NVVLD VM AK+G  L+S    
Sbjct: 61  QIEAVFEDIVPKAVKIGMLPNAEIMQIVAEKLAKFSAKNVVLDPVMQAKNGFNLMSE--R 118

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L S++L  + +ITPN+PEA  L +      E +M      +   G  +VL+KGGH + 
Sbjct: 119 ENLLSKMLGVIDIITPNIPEAEILTN-TEISNENDMKNAALIIAKKGAKSVLIKGGHKNG 177

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
             + D+L+       +    I TKNTHGTGCTLS+A+A+         + V+ AK ++  
Sbjct: 178 --TSDFLYFEGKFFEYKTKFINTKNTHGTGCTLSSAIASNLALGRKMNEAVENAKKYIQG 235

Query: 243 ALAQADTLEVGHGIGPVHHFHAW 265
            +  +  L++GHG GP++HF+  
Sbjct: 236 TIENS--LDLGHGAGPLNHFYNI 256


>UniRef50_C9LV61 Phosphomethylpyrimidine kinase n=1 Tax=Selenomonas sputigena ATCC
           35185 RepID=C9LV61_9FIRM
          Length = 296

 Score =  299 bits (766), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 110/264 (41%), Positives = 156/264 (59%), Gaps = 5/264 (1%)

Query: 1   MKRI-NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK I   LTIAG+DPSGGAGIQAD+KT +A   Y  ++ TAL  QNT G++  + I PDF
Sbjct: 34  MKDIRKVLTIAGSDPSGGAGIQADIKTITAHKMYAMNISTALTVQNTTGIRDTFVIPPDF 93

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +A QLD+++ D+R D  KIGM+A   IV  +AE+L+    +N+VLD V+ + SG  L++ 
Sbjct: 94  IAEQLDAIYDDIRPDAVKIGMVANDAIVHTIAEKLREKDAKNIVLDPVIASTSGCDLITS 153

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +  +   LLP V ++TPNLPEAAA+        E  ML+  + L      AVL+KGGH
Sbjct: 154 DTLFAMVDELLPLVDIVTPNLPEAAAITGVA-ITDEDSMLKAAKVLTERFPIAVLIKGGH 212

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L  E + D L+     + +   RI  +NTHGTGC LS A+A            V++AK++
Sbjct: 213 LV-ESADDLLYADGKARWYKQTRIDNENTHGTGCALSTAIACGLAAGKPLTIAVEDAKAY 271

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           ++ A+     L +G G GP+ H  
Sbjct: 272 ITGAIRAG--LNIGKGRGPLLHMW 293


>UniRef50_B7VS71 Phosphomethylpyrimidine kinase n=58 Tax=Bacteria RepID=B7VS71_VIBSL
          Length = 302

 Score =  298 bits (765), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 129/262 (49%), Positives = 178/262 (67%), Gaps = 1/262 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D  GGAGIQAD+K  SA G++ CSVITA+ +QNT+GV +++ I  D VA+Q
Sbjct: 35  PIVLTIAGSDSGGGAGIQADIKAMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVASQ 94

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD+VF+D+ I   K+GMLA++ I++ VA+++++Y+ +++V+D VM+A SGD LL  SA+ 
Sbjct: 95  LDAVFTDLNIVAVKVGMLADSQIIKVVADKIKQYRPKHLVIDPVMVATSGDLLLENSAIT 154

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-D 182
           TL+  L+P   +ITPNLPE AAL   P   +E EM      L A+G  AVL+KGGHL+ D
Sbjct: 155 TLKQELIPLADIITPNLPEGAALTGKPVPESEAEMQGMIEDLRALGAKAVLLKGGHLEKD 214

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E S D L         +A R  TKNTHGTGCTLS+A+A+   +    A+ V   K ++S 
Sbjct: 215 ENSNDLLILPTTSALISAKRFPTKNTHGTGCTLSSAIASFLAQGNTLAEAVDLGKQYISR 274

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+A AD L+VG G GPV+HF A
Sbjct: 275 AIAHADELQVGQGHGPVNHFFA 296


>UniRef50_A8PMT6 Phosphomethylpyrimidine kinase n=1 Tax=Rickettsiella grylli
           RepID=A8PMT6_9COXI
          Length = 278

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 113/262 (43%), Positives = 160/262 (61%), Gaps = 4/262 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            ++IAGTDPSGGAGIQAD+K  SA G+Y  S+IT LVAQNT+ V S+  I  DF+  Q+D
Sbjct: 10  VVSIAGTDPSGGAGIQADIKAISATGSYAASIITVLVAQNTQAVISLQDIPLDFIQQQID 69

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           +VF+D+ I+  K+GML    I+  +   L++YQ   +VLD VM+ ++G PLL P A+  L
Sbjct: 70  AVFTDLSINAVKLGMLYHEGIIRLIRHNLKKYQPPFIVLDPVMITQTGHPLLKPQAIQVL 129

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            + L P  +LITPN+PEA +LL+         M +    L      +VL+KGGH   + +
Sbjct: 130 ATDLFPLATLITPNIPEAESLLNLKII-DATTMQKAAVLLATRYKVSVLLKGGHSPYD-A 187

Query: 186 PDWLFT--REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            D  +   ++    F   RI TKNTHGTGCTLSAA+A+   +  N  + +  AK++L+  
Sbjct: 188 SDIFYDFSQKQIHYFKRARINTKNTHGTGCTLSAAIASYLAQGLNVVEAIFHAKNYLTQC 247

Query: 244 LAQADTLEVGHGIGPVHHFHAW 265
           L  A  L +G G GPV+HF+  
Sbjct: 248 LLAAKDLHLGQGQGPVNHFYFL 269


>UniRef50_Q65US6 ThiD protein n=2 Tax=Bacteria RepID=Q65US6_MANSM
          Length = 269

 Score =  294 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 115/266 (43%), Positives = 161/266 (60%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     LTIAG+D  GGAGIQADLKTF   G +G SVITA+ AQNT GV  ++ I    +
Sbjct: 1   MVIPQVLTIAGSDSGGGAGIQADLKTFQMRGVFGTSVITAVTAQNTLGVFDIHPIPLASI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQL +V  D  I   KIGML  T+I++ VA+ L++YQ  ++VLD VM+AK G  LL  S
Sbjct: 61  QAQLRAVAKDFSISAVKIGMLGNTEIIQCVADCLEQYQFSHIVLDPVMIAKGGATLLEQS 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AVA L++ +LP+  LITPN+PEA  +      + E ++    +    +G   V++KGGH 
Sbjct: 121 AVAALKNLILPKACLITPNIPEAERITG-TQIKNEADIFNAAQIFHELGANTVVIKGGHH 179

Query: 181 DDEQ---SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           ++ Q     DW+FT++G     APR  T +THGTGCT SA L A   +       V+ AK
Sbjct: 180 NNSQSKLCKDWVFTQKGYFTLEAPRFATPHTHGTGCTFSACLTAELAKGKPVEQAVRTAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFH 263
           +++++A+     L +GHG GP +H+ 
Sbjct: 240 NYITAAI--GHPLNIGHGHGPTNHWA 263


>UniRef50_C1AE24 Thiamine-phosphate pyrophosphorylase/phosphomethylpyrimidine kinase
           n=15 Tax=Bacteria RepID=C1AE24_GEMAT
          Length = 493

 Score =  293 bits (752), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 147/265 (55%), Positives = 178/265 (67%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +  NALTIAG+DPSGGAGIQADLKTF+A   YG + +TAL AQNTRGV  V+ + P FV 
Sbjct: 227 RIPNALTIAGSDPSGGAGIQADLKTFAAQRVYGMAALTALTAQNTRGVAGVHVVPPVFVL 286

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+S+F D+RID  KIGM+A  DI   VA+ L+      VVLD VM+AK G  LL P A
Sbjct: 287 QQLESLFDDIRIDAVKIGMIATADIATTVADVLEERMRGPVVLDPVMIAKGGAELLRPDA 346

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V  +R+RLLP  ++ITPNL EAA LL+ P A T  EM  Q   L A+G  AVL+KGGHL 
Sbjct: 347 VDAVRTRLLPLATVITPNLAEAAHLLNMPMASTRAEMETQATLLRALGPQAVLLKGGHLT 406

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           +E+SPD L T +G   F  PR+ T NTHGTGCTLSAA+AA      N    V+ AK +++
Sbjct: 407 EERSPDCLVTSDGVHWFDGPRVATANTHGTGCTLSAAIAAGLAGGGNLLTVVRTAKQYVT 466

Query: 242 SALAQADTLEVGHGIGPVHHFHAWW 266
            A+A A  L VGHG GP HHFH  W
Sbjct: 467 DAIASAHRLTVGHGHGPTHHFHNLW 491


>UniRef50_B6YRS2 Phosphomethylpyrimidine kinase n=2 Tax=Bacteroidales
           RepID=B6YRS2_AZOPC
          Length = 270

 Score =  293 bits (751), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 114/270 (42%), Positives = 165/270 (61%), Gaps = 5/270 (1%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L++AG+DPSGGAGIQADLKT SA G YG +VITA+V +NT  V++++ I   F
Sbjct: 1   MKHYKRVLSVAGSDPSGGAGIQADLKTVSACGCYGTTVITAIVDENTISVKNIHPIPISF 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLS 118
           V  Q+ SV +D+  D+ KIGML  ++++ AV      Y    N+VLD VM+A SGD LLS
Sbjct: 61  VIGQIHSVLNDIGTDSVKIGMLYSSELIRAVRNSFLTYNTIRNIVLDPVMVATSGDFLLS 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
            +++ TL++  +P V ++TPN+ EA  LLD       ++ L   + L      +VL+K G
Sbjct: 121 NNSIDTLKNEFIPFVRVVTPNIQEAEILLDRT-ITNAEDFLLAVKDLSFGRKVSVLLKAG 179

Query: 179 HLDDEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           HL++E   D  +    +    F+ PRI TKNTHGTGCTLS+A+AA         D +++A
Sbjct: 180 HLEEETLTDVFYNAETDEILYFSHPRIKTKNTHGTGCTLSSAIAAYLACGCILNDAIRKA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++++  A+       +G G GPVHHF  +W
Sbjct: 240 ETYIIQAIRVGSKYSIGKGHGPVHHFSHFW 269


>UniRef50_P61422 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=29
           Tax=Bacteria RepID=THIED_GEOSL
          Length = 490

 Score =  293 bits (751), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 110/242 (45%), Positives = 151/242 (62%), Gaps = 3/242 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT + LG+YG SV+TAL AQNTRGV  ++ + P FVA QLD+VFSD+ +D  K G
Sbjct: 242 IQADLKTVTLLGSYGSSVLTALTAQNTRGVSGIHGVPPAFVADQLDAVFSDIPVDVVKTG 301

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   + + A+A +L  Y+ + VV+D VM+AK G  L+   AV+ L+ RL P   L+TPN
Sbjct: 302 MLFSAETIVAIAAKLTEYRRRMVVVDPVMVAKGGANLIDRGAVSVLKERLFPLAYLVTPN 361

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L    +   E+ M E  R L  +G   VL+KGGHL    S D LF      RF 
Sbjct: 362 IPEAERLTG-ANISDEESMREAARRLHRLGARNVLLKGGHLLAGDSVDILFDGAAFHRFV 420

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +PRI++KNTHGTGCT ++A+A    +     + +  AK ++++A+  A  L  G G GPV
Sbjct: 421 SPRILSKNTHGTGCTFASAIATYLAQGDPLREAIARAKRYITAAIRLAQPL--GRGHGPV 478

Query: 260 HH 261
           +H
Sbjct: 479 NH 480


>UniRef50_B8FHR3 Phosphomethylpyrimidine kinase n=1 Tax=Desulfatibacillum
           alkenivorans AK-01 RepID=B8FHR3_DESAA
          Length = 272

 Score =  293 bits (750), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 100/259 (38%), Positives = 144/259 (55%), Gaps = 4/259 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+D   GAGIQADLKTF+ALG YG + ITA+ AQNT GVQ    + PD + AQ
Sbjct: 7   PVVLSIAGSDSGAGAGIQADLKTFAALGVYGTTAITAITAQNTLGVQDWQEVSPDLIVAQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V SD+R    K GML   + V  VA  ++   ++N+V+D VM AK G  LL   A  
Sbjct: 67  IRAVASDMRPKAVKTGMLGGPETVRTVAREIRDLGLENLVVDPVMKAKGGKDLLLQEAYE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +   L P   ++TPNL EA+ L+     +   ++ E  +++  MG  AV++KGGH   +
Sbjct: 127 VMVKELFPLARVVTPNLDEASELVGYD-VKDLSQIKEAAKAIQTMGPAAVVIKGGHSQGQ 185

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              D L+       +   RI T ++HGTGCT ++A+AA   +     + V  AK + + A
Sbjct: 186 P-NDLLYNGSEFFEYPGKRIDTPHSHGTGCTFASAVAAGLAKGMKVREAVFRAKEFTTRA 244

Query: 244 LAQADTLEVGHGIGPVHHF 262
           +     L  GHG   V+HF
Sbjct: 245 VKHGLPLGGGHGP--VNHF 261


>UniRef50_A1RUE5 Phosphomethylpyrimidine kinase n=24 Tax=cellular organisms
           RepID=A1RUE5_PYRIL
          Length = 450

 Score =  292 bits (749), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 97/264 (36%), Positives = 144/264 (54%), Gaps = 5/264 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    ++P  V
Sbjct: 1   MSWKVAMTIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLQPPLV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+ +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  
Sbjct: 61  RAQILAVWDDMGIDAGKTGMLGTREIIEEVAATVSKLGF-PLVVDPVMIAKSGAPLISED 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGH 179
           AV TL+ RLLP   ++TPN  EA  L       +  E       +    G   V++KGGH
Sbjct: 120 AVDTLKKRLLPVAKVVTPNRHEAEKLTGIK-ITSVAEARRAAEVIHREFGTEVVVVKGGH 178

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           LD  ++ D ++          PR+ ++ THGTGC+ SAA+AA   +     + ++ AK +
Sbjct: 179 LDAPEAVDVVYIGGTFHELATPRLDSRATHGTGCSYSAAIAAGLAKGLPPLEAIKTAKRF 238

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +  A+        G G  PV+   
Sbjct: 239 IYMAIRYGVA--RGKGHWPVNPMA 260


>UniRef50_C9KLG7 Phosphomethylpyrimidine kinase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KLG7_9FIRM
          Length = 268

 Score =  291 bits (746), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 116/266 (43%), Positives = 159/266 (59%), Gaps = 6/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   LTIAG+D SGGAG+QADLKT  A G YG S ITAL AQNT+GV+ V    P+F+
Sbjct: 1   MKK--VLTIAGSDSSGGAGVQADLKTMLANGVYGMSAITALTAQNTQGVRMVQEATPEFL 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AA+LD+VF D+R D  K+GM+A   ++  +A++L+ Y+ ++VV+D VM+A SG  LL   
Sbjct: 59  AAELDAVFEDIRPDAVKVGMVASPALIHVIADKLKAYKAEHVVVDPVMVATSGAKLLVDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L   L P   +ITPN+PE + L        E    +  + L A     VL KGGH 
Sbjct: 119 AIEVLVQELFPLAEVITPNIPELSVLTG-AEIADEFAFEQAAKKLAAEAEVNVLAKGGHF 177

Query: 181 DDEQSPD-WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D+ S    L   EGEQ +   R+   NTHGTGCTLS+A+AA   +  +  +++  AKS+
Sbjct: 178 ADDASDLLVLAGGEGEQWYRGTRVANPNTHGTGCTLSSAIAANLAKGFDLDESIGRAKSY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           L  AL     +++G G GPV H    
Sbjct: 238 LFGALLA--KMDLGRGNGPVDHGWNL 261


>UniRef50_C6LBN3 Phosphomethylpyrimidine kinase n=1 Tax=Bryantella formatexigens DSM
           14469 RepID=C6LBN3_9FIRM
          Length = 330

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 117/307 (38%), Positives = 159/307 (51%), Gaps = 53/307 (17%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D SGGAGIQADLKT  A   YG SVITAL AQNT GV  +    P+FVA Q+
Sbjct: 4   KVLTIAGSDCSGGAGIQADLKTMMAHDVYGMSVITALTAQNTTGVYGILETPPEFVAQQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D VF D+R D  KIGM+ +  I+E +AE+L++YQ +N+V+DTVM++ SG  L+S  A+ T
Sbjct: 64  DCVFQDIRPDAVKIGMVPDCGIMEVIAEKLKQYQAENIVIDTVMISTSGHRLMSEQAMQT 123

Query: 125 LRSRLLPQVSLITPNLPEAAAL------LDAPHAR------------------------- 153
              +LLP  ++ITPNLPEA AL            +                         
Sbjct: 124 YTEKLLPLAAVITPNLPEAEALYQYETGAGIRAEKGSYQNETGAGIRAEKGSYQNETGAG 183

Query: 154 -------------------TEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREG 194
                              +E++M      +     GA+L+KGGHL  + + D L     
Sbjct: 184 IRAEKGSFQNETGAGFHAGSEEDMKRMAEKIAGRYGGALLIKGGHLCGD-AADLLCENGN 242

Query: 195 EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
              F   RI   N+HGTGCTLS+A+A    +     ++V  AK +++ AL     L +G 
Sbjct: 243 FHWFRTERIQNPNSHGTGCTLSSAIACNLAKGKTVYESVYAAKEYVTDALRAG--LNLGR 300

Query: 255 GIGPVHH 261
           G GP+ H
Sbjct: 301 GSGPLAH 307


>UniRef50_O67772 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Aquifex aeolicus RepID=THID_AQUAE
          Length = 255

 Score =  290 bits (744), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 99/251 (39%), Positives = 143/251 (56%), Gaps = 1/251 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           + AL+IAG D SGGAG  AD++TF   G YG +VITAL  QNT+ V  V+ I PD V  +
Sbjct: 1   MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEE 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L ++F D  I   KIGMLA  +I E V E L+  +   +VLD V  +KSG  LLS   V 
Sbjct: 61  LKAIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVE 120

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L+S  +  V LITPN+PEA  L      ++ +++    + + ++G  +VL+KGGHL   
Sbjct: 121 FLKSEFIKIVDLITPNVPEAEILCG-EEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGN 179

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L+  +    F AP+I  K   GTGC  S+A+ A   RH +    ++ AK +++ A
Sbjct: 180 YAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEA 239

Query: 244 LAQADTLEVGH 254
           +  +  L  G+
Sbjct: 240 IKNSKKLGKGY 250


>UniRef50_B9CYF9 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter rectus RM3267
           RepID=B9CYF9_WOLRE
          Length = 264

 Score =  290 bits (744), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 98/266 (36%), Positives = 148/266 (55%), Gaps = 7/266 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L+IAG DPSGGAG+ ADLK F+A G Y    ITAL AQNT+G+  +  +E D +
Sbjct: 1   MKH--VLSIAGVDPSGGAGVIADLKVFAAHGVYAMGAITALTAQNTKGIFDMQLVECDLI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSP 119
           A Q++++F D+R+D  KIG++    I++ VA  L++      VVLD VM  K+GD  L  
Sbjct: 59  AKQIEAIFDDIRVDAVKIGVVPSEQIIKTVAATLRKVSNLPPVVLDPVMSCKNGDIWLEG 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           +A   + S L P  ++ITPN  EA  ++     +++ E  +  + LL  G  +V +K G 
Sbjct: 119 AAKDAIVSELFPLSTVITPNKFEAREIV-KREPKSKDEFKQACKELLKTGAKSVYLKCGD 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +    S D  +       F   RI T +THG+GC+LS+A+A+      +  ++ Q A  +
Sbjct: 178 V-GGVSLDLFYDGAEFTEFEQERIDTSSTHGSGCSLSSAIASNLALGFSLRESAQRANKY 236

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           +  A+  A    VG G  P++HFH  
Sbjct: 237 VYKAIKAAFA--VGSGCNPINHFHNV 260


>UniRef50_Q6KZH7 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=1
           Tax=Picrophilus torridus RepID=Q6KZH7_PICTO
          Length = 256

 Score =  290 bits (743), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 93/259 (35%), Positives = 148/259 (57%), Gaps = 4/259 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +T+A TD  GGAG+ ADLKT +AL  +G +VI +L AQN+  V+S+Y +   F+  Q   
Sbjct: 1   MTVASTDSGGGAGVMADLKTMTALKVFGTAVIVSLTAQNSVSVRSIYELPEQFIRDQFYE 60

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + SD+  D  K GML   +I+  V + ++ Y ++N+V+D VM++K+G  LL   A+  L 
Sbjct: 61  ILSDIGTDAAKTGMLFSENIINTVYDEMKSYNVKNIVIDPVMVSKTGARLLKEDAIKALV 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
           ++L+   +L+TPN+PEA  +          +M      +  M   +VL+KGGH++   S 
Sbjct: 121 NKLMKIATLVTPNIPEAEVITGMR-ISDLNDMKNAALKIYNMTGASVLIKGGHMESSVSE 179

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D L+  E    ++  RI TKNTHGTG TLS+A+A+         D++  AK ++  A+  
Sbjct: 180 DVLYNGE-FSFYSDKRINTKNTHGTGDTLSSAIASYLAMGKTLEDSISMAKDYIEGAIIN 238

Query: 247 ADTLEVGHGIGPVHHFHAW 265
           +    +G G GP++HF   
Sbjct: 239 S--FPMGRGYGPLNHFWRI 255


>UniRef50_A8NYV6 Putative uncharacterized protein n=2 Tax=Agaricales
           RepID=A8NYV6_COPC7
          Length = 556

 Score =  289 bits (741), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 118/311 (37%), Positives = 153/311 (49%), Gaps = 53/311 (17%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           ALTIAG+DPSGGAGIQADLKTF+A G YG SVIT+L AQNT GVQ V+ + PDFV  QL 
Sbjct: 9   ALTIAGSDPSGGAGIQADLKTFAAHGCYGASVITSLTAQNTTGVQGVHAVPPDFVVQQLR 68

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI----QNVVLDTVMLAKSGDPLLSPSA 121
            VF D+ I   K GML +  I   VA+ L+  Q       VV D V ++ SG  LL P A
Sbjct: 69  MVFDDIDIKAIKTGMLYDAVIAAEVAKVLKERQAAGKLAPVVCDPVCVSTSGHTLLKPDA 128

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAP----HARTEQEMLEQGRSLLAMGCGAVLMKG 177
           +  L S++ P  +LITPN PE   LL  P       +  +M      L      AVL+KG
Sbjct: 129 LDVLVSQVFPLTTLITPNKPETELLLKTPNSEVKIESLADMYTAAVELSKKTSTAVLVKG 188

Query: 178 GH-----------------------------------------LDDEQSPDWLFTREGE- 195
           GH                                         L+ E   D L+  + + 
Sbjct: 189 GHVVSSLKNLEEITQKHSNVEVVKQNLYDENMEILLVGRDPKELNPEIVVDLLYQPDTQS 248

Query: 196 -QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
              +  PRI + +THGTGCTLSAA+A+   +  +  D V +   +    +A A    +G 
Sbjct: 249 AVVYARPRIESTSTHGTGCTLSAAIASGLAQGLSLKDAVAQGALYTHFGIATAQ--PIGK 306

Query: 255 GIGPVHHFHAW 265
           G GP++H H  
Sbjct: 307 GYGPLNHLHCV 317


>UniRef50_O94266 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
           n=2 Tax=Schizosaccharomyces RepID=THI22_SCHPO
          Length = 551

 Score =  289 bits (741), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 98/277 (35%), Positives = 145/277 (52%), Gaps = 18/277 (6%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              +LTIAG+D SGGAGIQADLKT ++LG YG S IT LVA+N  GV SV  + P FV +
Sbjct: 35  LPVSLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVES 94

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D    D+     K GML   +IV+AVA   +++    +V+D VM+A SGD L++   V
Sbjct: 95  QIDCCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIV 154

Query: 123 ATLRSRLLPQVSLITPNLPEAAAL-----LDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
           + L   LLP   L+TPN+PEA  L     LD  +  +  +M      +  +G   VL+KG
Sbjct: 155 SVLNEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKG 214

Query: 178 GHL------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR 225
           GH+            +D +  D L+       F++  +     HGTGCTLS+A+A+    
Sbjct: 215 GHMPVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAW 274

Query: 226 HTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHF 262
             +  + VQ    ++  A+  +  +        ++H 
Sbjct: 275 EHSLTEAVQFGIDYVHGAITHSPPINNCS-TNILNHM 310


>UniRef50_Q3YSR2 Phosphomethylpyrimidine kinase n=8 Tax=Anaplasmataceae
           RepID=Q3YSR2_EHRCJ
          Length = 269

 Score =  288 bits (739), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 92/264 (34%), Positives = 148/264 (56%), Gaps = 7/264 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +   LTIAG+D  GGAGIQAD+KT SALG Y  S IT++ AQNT  V +VY +  + +  
Sbjct: 7   KGKVLTIAGSDSCGGAGIQADIKTISALGCYAASCITSVTAQNTSQVYNVYNMPQNIIKQ 66

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++V SD+ ID  KIGML  ++ + AVA+ L       +V+D VM++ S   L+  SA+
Sbjct: 67  QIEAVLSDIDIDAIKIGMLPSSEAIIAVAQSL---PHIPIVVDPVMISTSNFRLMDNSAI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
                 ++ + ++ITPN+ EA  L        + +M++  + + ++G   VL+KGGH++ 
Sbjct: 124 FDFIKHIIYRATIITPNITEAEVLAQTKII-NQDDMIKASQQIKSLGAKYVLIKGGHINQ 182

Query: 183 EQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           E   + L T + +   F   RI     HGTGCTLS+A+A+   +  +  ++V  A  ++ 
Sbjct: 183 ETINNILLTEDNQILNFPHQRIFDGELHGTGCTLSSAIASFISQKISVQESVNLAIQYIL 242

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
             +      ++G G  PV H +  
Sbjct: 243 KTIKTVP--QIGKGNNPVFHNYNV 264


>UniRef50_C5BTK8 Phosphomethylpyrimidine kinase n=1 Tax=Teredinibacter turnerae
           T7901 RepID=C5BTK8_TERTT
          Length = 274

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 114/265 (43%), Positives = 162/265 (61%), Gaps = 2/265 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L IAG+DP GGAG+QAD+KT +ALG Y C+V TAL AQN+RGV +V+ + P+ + 
Sbjct: 4   QIPVVLAIAGSDPLGGAGLQADIKTAAALGGYCCTVTTALTAQNSRGVSAVWPVAPEQLR 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ  +V  D+     K+GML    ++  +A  L+      VVLD V+ A +G  LLS ++
Sbjct: 64  AQFSAVTEDITPGAIKVGMLGNAALIAELANLLRTQPNVPVVLDPVLAATAGGDLLSNAS 123

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              L ++LLP+V+L+TPNL EA+ LL+ P A  E +ML Q ++L  MG  AVL+KGGHL 
Sbjct: 124 GE-LVAQLLPRVTLLTPNLHEASRLLNCPPALDESDMLVQAKALREMGPRAVLIKGGHLA 182

Query: 182 DEQSPDWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             ++ D L +     QRF +PR+  +NTHGTGCTL+ A+A            V  AK ++
Sbjct: 183 SSRAIDILLSETNTVQRFASPRLAARNTHGTGCTLATAIATGLAAGHALPVAVACAKRFI 242

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
             A+A AD+L +    GP+ HF A 
Sbjct: 243 QQAIAHADSLNLVDENGPLQHFFAV 267


>UniRef50_Q0AZ88 Phosphomethylpyrimidine kinase n=1 Tax=Syntrophomonas wolfei subsp.
           wolfei str. Goettingen RepID=Q0AZ88_SYNWW
          Length = 290

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 119/276 (43%), Positives = 154/276 (55%), Gaps = 18/276 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++   LTIAG+D   GAGIQAD+KT  ALGAY  SVITA+ AQNTR V +V  IE   +
Sbjct: 1   MRK--ILTIAGSDSCAGAGIQADIKTIQALGAYALSVITAVTAQNTRQVTAVREIEALVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY------------QIQNVVLDTVM 108
             QL+++FSD+R+D  KIGML     V+AV+  L  +                +V+D VM
Sbjct: 59  EKQLEAIFSDIRLDGIKIGMLGRAGTVQAVSNFLASFFQAGAFWEKQLKNSLPLVVDPVM 118

Query: 109 LAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAM 168
           +AKSGD LL   AV +L+  LLP  S+ITPNL EA ALL      + +EM E  R LL  
Sbjct: 119 IAKSGDRLLEEEAVESLKKNLLPLASVITPNLMEAGALLG-REISSLEEMKEAARELLEF 177

Query: 169 GCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
           GC   ++KGGHL  E   D L  ++        R+ T   HGTGCT SAALA L  +   
Sbjct: 178 GCQWAIVKGGHLKGEP-VDVLANKDSLYLLRGQRVDTNCNHGTGCTFSAALATLMGQGLA 236

Query: 229 WADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
                + AK+++   L       +G G+G  HHF A
Sbjct: 237 VPAAAKRAKAYVEYCLEHGFA--IGEGVGIPHHFAA 270


>UniRef50_UPI000185BF73 multifunctional protein thiED n=1 Tax=Corynebacterium amycolatum
           SK46 RepID=UPI000185BF73
          Length = 537

 Score =  286 bits (733), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 116/261 (44%), Positives = 162/261 (62%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAG+ ADLK+ +A G YG  V+TALV+QNT GV++V+    DF+  Q
Sbjct: 13  PRVLSIAGTDPTGGAGLHADLKSIAAAGGYGMGVVTALVSQNTVGVRAVHTPPVDFLVEQ 72

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  DV ID  KIGML   ++ +AV   ++  +   VVLD VM+A SGD LL   A+ 
Sbjct: 73  LAAVTEDVTIDAVKIGMLGSRELTQAVTNWVRETKPAVVVLDPVMVATSGDRLLDEDAMD 132

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R  L+ + ++ITPN+PE A L DAP A    E++EQ     +     V+ K GHL DE
Sbjct: 133 AMRD-LVTEATVITPNVPELALLADAPEASDFTELIEQALEFASENDVIVIAKTGHLSDE 191

Query: 184 QSPDWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           ++ + +   +G+  F ++PRI T+NTHGTGC+LSAALA      +   D ++    WLS 
Sbjct: 192 EAGNAVAFPDGQVFFSSSPRIHTENTHGTGCSLSAALATRIGGGSAINDALRWTTRWLSE 251

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           ++  AD L VG G GP+ H H
Sbjct: 252 SIRFADNLNVGQGHGPIDHGH 272


>UniRef50_Q7UNH4 Probable thiamin biosynthesis protein n=1 Tax=Rhodopirellula
           baltica RepID=Q7UNH4_RHOBA
          Length = 275

 Score =  286 bits (733), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 107/256 (41%), Positives = 151/256 (58%), Gaps = 6/256 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+DPSGGAG+QADLKTF + G YGCSV+T L AQNT GVQ +  +  +FV AQ
Sbjct: 19  PVALTIAGSDPSGGAGMQADLKTFHSFGVYGCSVMTLLTAQNTMGVQGIQMVPAEFVRAQ 78

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             SV SD+ +   K G L   +++E VA+ L       +V+D VM++K G P++  +A+ 
Sbjct: 79  WTSVSSDLPLAAIKTGALGNAELIETVADCLHSL-ACPLVVDPVMISKHGHPIIDENAID 137

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L +R+ P   L+TPN  EA  L+     R E ++      LLAMG  AVL+K      E
Sbjct: 138 VLINRVFPLADLVTPNAFEAERLVG-QSIRNEDDLASVADKLLAMGPRAVLIKACV--GE 194

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +S D L   +G Q   +PRI +  THG+GC LSAA+ A   +  +  + V+ A++++  A
Sbjct: 195 RSVDCLADADGAQLLRSPRIESNRTHGSGCVLSAAITAGLAKGQDLIEAVRTARNFVHDA 254

Query: 244 LAQADTLEVGHGIGPV 259
           +  A  L  G GI P+
Sbjct: 255 IRNAPKL--GQGISPL 268


>UniRef50_B4RNJ4 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=B4RNJ4_NEIG2
          Length = 288

 Score =  285 bits (731), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 103/247 (41%), Positives = 145/247 (58%), Gaps = 6/247 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF   G +G  VITA+ AQNT GV +V+ +  + + AQ+ ++  D  I   KIG
Sbjct: 42  IQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKIG 101

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA++L+       VLD VM+AK G PLL  SAVA L   LLP   ++TPN
Sbjct: 102 MLGTAEIIECVADKLKHCSFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDILTPN 161

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD---EQSPDWLFTREGEQ 196
           LPEA AL         ++     + LL  G   V++KGGHL+     +  DWLFT+    
Sbjct: 162 LPEAEALTGVH-IENRKDAERAAKILLDYGVKNVIIKGGHLNGSTSGRCTDWLFTQNETL 220

Query: 197 RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGI 256
              +PR  T +THGTGCT SA + A   +  +    VQ AK+++++A+  ++ LE+G G 
Sbjct: 221 ELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVQTAKAYITAAI--SNPLEIGAGH 278

Query: 257 GPVHHFH 263
           GPV+H+ 
Sbjct: 279 GPVNHWA 285


>UniRef50_Q3D6X9 Phosphomethylpyrimidine kinase n=9 Tax=Streptococcus agalactiae
           RepID=Q3D6X9_STRAG
          Length = 265

 Score =  285 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 111/257 (43%), Positives = 149/257 (57%), Gaps = 5/257 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTIAGTDPSGGAGI ADLKTF A   YG +V+T++VAQNT GV+ V  IE   +  QL 
Sbjct: 7   VLTIAGTDPSGGAGIMADLKTFQARRTYGMAVVTSVVAQNTCGVRGVQHIETAIIDQQLA 66

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            V+ D++    K GMLAE + +  VA  L++Y     VLD VM+A SG  L+   AV  L
Sbjct: 67  CVYDDIKPKAVKTGMLAERETISLVASYLKKYPQ-PYVLDPVMVATSGHRLIDSDAVEAL 125

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGC-GAVLMKGGHLDDEQ 184
           +  LLP  ++ITPNLPEA  L+       E  +++ G  +        VL+KGGHLD   
Sbjct: 126 KEDLLPLATIITPNLPEAEVLVGYD-LSDEVSIIKAGYDIQKQYSVRNVLIKGGHLDGLA 184

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
                  +EG    +  RI T +THGTGCT +A +AA   +  +  + V  AKS+++SA+
Sbjct: 185 KDYLFLEKEGLITLSNQRINTIHTHGTGCTFAAVVAAELAKGQSILNAVSTAKSFITSAI 244

Query: 245 AQADTLEVGHGIGPVHH 261
             A  L +G   GPV+H
Sbjct: 245 ETAPELGLG--NGPVNH 259


>UniRef50_A1A2J4 Phosphomethylpyrimidine kinase n=66 Tax=Bacteria RepID=A1A2J4_BIFAA
          Length = 280

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 112/277 (40%), Positives = 151/277 (54%), Gaps = 16/277 (5%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               L+IAG+D SGGAGIQADLKT  A G +G + I AL AQNT GV  V    P+ +AA
Sbjct: 5   LPPVLSIAGSDSSGGAGIQADLKTMLANGVFGMTAIAALTAQNTTGVTMVTNTPPEMLAA 64

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+VF D+     KIGM++  +++  +A+RL  +  +NVVLD VM+A SG  L+   A+
Sbjct: 65  QIDAVFEDIPPVAVKIGMVSSAELITVIADRLTAHNAKNVVLDPVMVATSGAKLIEDDAI 124

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLD--------------APHARTEQEMLEQGRSLLAM 168
           A L S+L P  ++ITPN+PE   L D                   TE +M+  G  L   
Sbjct: 125 AALTSKLFPLATVITPNMPETQVLCDLAVEQGAGAIDYENGESISTENDMVTAGHLLAGH 184

Query: 169 GCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN 228
              AVL+KGGH   + S   +        F + RI   NTHGTGCTLS+A+A+       
Sbjct: 185 FGCAVLVKGGHGTHDASDVLVEPDGKITWFRSRRINNPNTHGTGCTLSSAIASHLALGEA 244

Query: 229 WADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
               V  AK +L+ AL     L++GHG GP+ H   W
Sbjct: 245 LPTAVDHAKLYLTGALEA--QLDLGHGSGPMDHAWKW 279


>UniRef50_O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_BACSU
          Length = 271

 Score =  284 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 107/264 (40%), Positives = 149/264 (56%), Gaps = 4/264 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQAD+KTF  L  +G S ITA+ AQNT GV  V+ +  + +
Sbjct: 1   MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  D+R D  K GML   D++E VA ++  Y    V++D VM+AK G  LL   
Sbjct: 61  RQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           +VATL+  L+P+   ITPN+PEA  L       +  +  +    L+ MG   V++KGGH 
Sbjct: 121 SVATLKELLIPRSYAITPNVPEAETLTGMT-ISSLDDRKKAAEQLVKMGAQHVIIKGGHQ 179

Query: 181 -DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +D    D LF      + T P I TK+THGTGCT +AAL A   +  +     + A ++
Sbjct: 180 PEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANF 239

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +  A+     L +G G GP +HF 
Sbjct: 240 VREAVENT--LGIGSGHGPTNHFA 261


>UniRef50_Q5WHJ3 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WHJ3_BACSK
          Length = 275

 Score =  284 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 108/261 (41%), Positives = 161/261 (61%), Gaps = 4/261 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAGTDP+GGAGIQADLKTF  L  YG SVIT+LVAQNT GV++++ +  +F+  Q 
Sbjct: 6   RALTIAGTDPTGGAGIQADLKTFQELEVYGMSVITSLVAQNTTGVRAIHHVPLEFIDQQF 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D+     K GM+A  +++E + ++L  ++    V D VM+AK+GDPLL     A 
Sbjct: 66  QAVVDDIYPSAIKTGMIALPEMMELLQQQLNSHKNVPYVCDPVMMAKNGDPLLEKHVRAK 125

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           LR  L+P  +++TPN+ EA  L+D      +       R +  +G  +V++KGG L  + 
Sbjct: 126 LRETLVPLATIVTPNIAEAEDLIDMQIDDIDDMEKAAIRIVKELGAQSVVVKGGSLTGD- 184

Query: 185 SPDWLFTRE-GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           + D  ++RE G  +  APR  TK+THGTGCT SAA+ A   +     D VQ+AK++ + A
Sbjct: 185 AVDVFYSRETGLFKLDAPRTDTKHTHGTGCTFSAAICAQLAKGIALLDAVQKAKAFTADA 244

Query: 244 LAQADTLEVGHGIGPVHHFHA 264
           +    +L++G+G GP +H+  
Sbjct: 245 I--TWSLQIGNGYGPTNHWGH 263


>UniRef50_Q5WH83 Phosphomethylpyrimidine kinase n=2 Tax=Bacillus RepID=Q5WH83_BACSK
          Length = 272

 Score =  284 bits (727), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 105/261 (40%), Positives = 153/261 (58%), Gaps = 2/261 (0%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L++AG+D SGGAGIQAD+KT   LG Y  + ITA+ AQNT GVQS   ++   V
Sbjct: 1   MPIPTVLSVAGSDSSGGAGIQADIKTCQELGVYAATAITAITAQNTTGVQSWQGLDASLV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++V SD+ +   K GML   DIV  VAE    Y++ N+V+D VM + SG  LLS  
Sbjct: 61  RDQIEAVLSDIGVHVIKTGMLVNADIVTTVAELANTYRVANIVVDPVMASTSGTALLSAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L  +LLP  ++ TPNLPE A LL+ P  +T  EM      L  MG   V++KGGHL
Sbjct: 121 GQQVLVQKLLPLATVFTPNLPETAMLLNKPECKTVAEMKAAAVQLHKMGPKLVILKGGHL 180

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
              ++ D  +  +      A R+  K+THGTGCT ++A+AA   +     +  ++AK+++
Sbjct: 181 RQGEAIDLCYDGQAFFELKAKRLDRKHTHGTGCTFASAIAAELAKGAKPIEAAKKAKAYV 240

Query: 241 SSALAQADTLEVGHGIGPVHH 261
           ++A+  ++ + +G GIGP  H
Sbjct: 241 TAAI--SEGIPLGAGIGPTDH 259


>UniRef50_P56904 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=348
           Tax=Bacteria RepID=THID_RHIME
          Length = 266

 Score =  283 bits (726), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 122/247 (49%), Positives = 163/247 (65%), Gaps = 1/247 (0%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTFSALG YG SVITA+ AQNTRGV +V  +  + V+AQ+D+VFSD+ +   KIG
Sbjct: 19  IQADLKTFSALGVYGASVITAITAQNTRGVTAVEDVSAEIVSAQMDAVFSDLDVKAVKIG 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           M++  + + A+A+ L+R+  +  V+D VM+A SGD LL P AVA L   LLP   ++TPN
Sbjct: 79  MVSRRETIAAIADGLRRF-GKRAVVDPVMVATSGDALLRPDAVAALIEELLPLALVVTPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L EAA +     A  E EM  Q  +++  G  AVL+KGGHL  +++ D  F  +   R  
Sbjct: 138 LAEAALMTGRAIAGDEAEMARQAEAIMRTGAHAVLVKGGHLKGQEATDLFFDGDTLVRLP 197

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           A RI T+N HGTGCTLSAA+AA   +     + V  AK++L +A++ AD LE+G G GPV
Sbjct: 198 AGRIETRNDHGTGCTLSAAIAAGLAKGVPLIEAVSAAKAYLHAAISAADRLEIGQGRGPV 257

Query: 260 HHFHAWW 266
           HHFH WW
Sbjct: 258 HHFHRWW 264


>UniRef50_C1XR49 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Meiothermus silvanus DSM 9946 RepID=C1XR49_9DEIN
          Length = 278

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 115/259 (44%), Positives = 156/259 (60%), Gaps = 4/259 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALT+AG+DPSGGAG+QADLKTF   G YG  V+T L  QNT GV+ V  +EP  VA QL
Sbjct: 17  IALTVAGSDPSGGAGLQADLKTFHRFGVYGMGVVTVLTVQNTLGVREVVPLEPALVARQL 76

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           ++V  D      K G L +  IV ++A  L +     +V+D V++AKSGD LL   A+  
Sbjct: 77  EAVLHDPGAHAIKTGALGDAAIVHSIAPLLAQ-AALPLVVDPVLVAKSGDSLLGGEALEA 135

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L+S LLP  +L+TPNL EA ALL  P  R   +  E  R L  +G  AVL+KGGHL  ++
Sbjct: 136 LKSCLLPIAALLTPNLLEAQALLGQP-IRDLADAREAARLLACLGPRAVLLKGGHLAGKE 194

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D L+       F   +I + +THGTGCTLSAA+ AL  +     + V  AK +++ A+
Sbjct: 195 ATDVLWDGHALHLFPEWKIPSVHTHGTGCTLSAAITALLAKGIPLHEAVARAKRFVTRAI 254

Query: 245 AQADTLEVGHGIGPVHHFH 263
           A A    +G GIGP++H+ 
Sbjct: 255 ATAP--GIGRGIGPLNHWA 271


>UniRef50_C6D361 Phosphomethylpyrimidine kinase n=75 Tax=Bacillales
           RepID=C6D361_PAESJ
          Length = 275

 Score =  283 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 104/244 (42%), Positives = 146/244 (59%), Gaps = 3/244 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF  LGAYG S +TA+ AQNT GVQ V+ +  + V AQ+ SV SD+ +D  K G
Sbjct: 26  IQADLKTFQELGAYGMSALTAITAQNTLGVQGVFPLAKEAVKAQIHSVGSDIGVDALKTG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VAE +  +  + VV+D VM+AK G  LL   AV  L  +LLP   +ITPN
Sbjct: 86  MLFSAEIIEEVAEAIAFFGWKKVVVDPVMIAKGGASLLQVEAVRALSRKLLPLTMIITPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L      R + + LE  + L ++G   VL+KGGH     + D L+   G    +
Sbjct: 146 IPEAEHLTGMA-IRNKNDKLEAAKKLSSLGARYVLIKGGHEAGADAVDLLYDGSGYSELS 204

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             RI+T+ THGTGCT SAAL A   +  +  + V++AK+++ +A+     + VG G GP 
Sbjct: 205 GKRIVTERTHGTGCTYSAALTAGLAQGLDIEEAVRQAKAYIQAAIEDG--IIVGSGHGPT 262

Query: 260 HHFH 263
           +H+ 
Sbjct: 263 NHWA 266


>UniRef50_C5U665 Phosphomethylpyrimidine kinase n=1 Tax=Methanocaldococcus infernus
           ME RepID=C5U665_9EURY
          Length = 442

 Score =  283 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 88/257 (34%), Positives = 139/257 (54%), Gaps = 8/257 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+D   GAGI+ADLKTF + G YG   ITA+ AQNT  ++ +  ++   V  Q
Sbjct: 8   KKALTIAGSDSGSGAGIEADLKTFCSFGVYGLVAITAITAQNTYEIREIRELDAKIVREQ 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V  D  +D  K GML   +I++ V + ++ YQ   +V+D VML+K+   LL   A+ 
Sbjct: 68  IIAVAEDFGVDAAKTGMLYSGEIIKEVRKVVKDYQF-PLVVDPVMLSKTNTLLLKEDAIE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   L    +LITPN+ EA  L          + +E  ++L       +L+KGGHL  E
Sbjct: 127 KL-ENLFKISTLITPNINEAEFLSS-KKITNLDDAIEVAKTLFEKYKTNILIKGGHLKGE 184

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L+  E  + F + R+ +  THGTGC+ SAA+ A   +     + +++AK ++  +
Sbjct: 185 -AIDILYNGE-LKLFKSQRV-SGCTHGTGCSFSAAITACLAKGEELEEAIKKAKDFIIKS 241

Query: 244 LAQADTLEVGHGIGPVH 260
           +  +    +G    PV+
Sbjct: 242 IRNS--YRIGKKYCPVN 256


>UniRef50_D1BR35 Phosphomethylpyrimidine kinase n=4 Tax=Firmicutes
           RepID=D1BR35_VEIPT
          Length = 277

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 104/264 (39%), Positives = 156/264 (59%), Gaps = 6/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   ALTIAGTDPSGGAGI ADLK+F +   YG +V+T++VAQNT GV  V  +  + +
Sbjct: 1   MKLHTALTIAGTDPSGGAGIMADLKSFQSRNVYGMAVVTSVVAQNTTGVHHVEHLSLESI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL  V+SD+     K GM+A  ++++ +   + +      V+D VM+A SGD L+S  
Sbjct: 61  EKQLHDVYSDITPQAVKTGMIALPEMMDLIYPYVSK--NIPYVMDPVMIATSGDRLVSDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV  L+S+L+P  ++ITPN  EA  L D              R L  +G   V++KGGH+
Sbjct: 119 AVDFLKSKLIPVATVITPNRSEAEVLADMSITCESDITTAANRILRELGPQVVIIKGGHI 178

Query: 181 DDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D+ + D+ FT++G+   +T+P+  T +THGTGCT SA + A   +  +  D +  AK++
Sbjct: 179 GDD-ATDYAFTKDGDMHTWTSPKYDTVHTHGTGCTFSAVITAELAKGRDVMDAIGIAKNY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           ++ A+     L  G+G GPV+H  
Sbjct: 238 IALAIKHNPAL--GNGCGPVNHMA 259


>UniRef50_Q6C731 YALI0E04224p n=1 Tax=Yarrowia lipolytica RepID=Q6C731_YARLI
          Length = 513

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 101/284 (35%), Positives = 150/284 (52%), Gaps = 24/284 (8%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD-FV 60
           +  + LTIAG+D SGGAGI+ADLKT +  G YG + IT L AQNT GV+ ++ IE   F+
Sbjct: 5   RPPSVLTIAGSDSSGGAGIEADLKTITVHGCYGMTTITGLTAQNTTGVEKIHPIEDQGFI 64

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSP 119
            A LD+VFSDV +D  K GML+  + +  V   L+++      V+D V+ + SG  L   
Sbjct: 65  TACLDAVFSDVGVDVVKTGMLSSQETITTVTNYLKKHHANKASVIDPVLCSTSGSTLFPA 124

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDA------PHARTEQEMLEQGRSLLAMGCGAV 173
             V+     L    +++TPN+PEA  L            +T Q+M +   S+   G   V
Sbjct: 125 EYVSVYLE-LFGLATIVTPNIPEAVELASVLEKKKFETPKTVQDMKDLAVSIHKTGAKWV 183

Query: 174 LMKGGHLD-------------DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALA 220
           L+KGGHL              D+   D L+  +       P I TK+THGTGCTL++A+A
Sbjct: 184 LIKGGHLSFTKDKEPAKENDTDKVVIDVLYDGKDFTELVMPYITTKSTHGTGCTLASAIA 243

Query: 221 ALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
           +   +  +    V E   ++ +A+ +A    +G G GPV+H + 
Sbjct: 244 SNLAKGKDIPQAVLEGTQYIQNAIFEAH--PIGKGHGPVNHTYN 285


>UniRef50_A3P597 Phosphomethylpyrimidine kinase n=30 Tax=Proteobacteria
           RepID=A3P597_BURP0
          Length = 336

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 148/263 (56%), Positives = 178/263 (67%), Gaps = 2/263 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAGTDP+GGAGIQADLK FSA+ AYG + ITA+VAQNT GV+S   ++P FVA Q+
Sbjct: 74  NVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQI 133

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+VF DV +   KIGM+A   I EAVA  L R++   VVLD VM+AKSGD LL P AV  
Sbjct: 134 DAVFDDVAVHAVKIGMIATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDA 193

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R +L+P  +LITPNLPEA  LL     RT  EM      L A+G   VL+KGGHL  E+
Sbjct: 194 IRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWVLLKGGHLAGER 253

Query: 185 SPDWLFTR-EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           S D L          +APR+ T N HGTGCTLSAA+AAL P   +  D+V +AK++LS A
Sbjct: 254 SVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPS-HSVEDSVCQAKAYLSDA 312

Query: 244 LAQADTLEVGHGIGPVHHFHAWW 266
           LA +  LEVG G GPVHHFHA W
Sbjct: 313 LAASGELEVGRGHGPVHHFHALW 335


>UniRef50_C5VF19 Multifunctional protein thiED n=3 Tax=Corynebacterium
           RepID=C5VF19_9CORY
          Length = 730

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 122/272 (44%), Positives = 157/272 (57%), Gaps = 8/272 (2%)

Query: 1   MKRI---NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           M+R      L+IAGTDP+GGAG QADLK+ +A G YG + ITALVAQNT GV+S++    
Sbjct: 223 MRRPSVPRVLSIAGTDPTGGAGAQADLKSIAAAGGYGMNAITALVAQNTHGVRSIHTPPL 282

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL 117
            F+  QLD+V SDV ID  KIGML   DIV  V + L  + +  VVLD VM+A SGD LL
Sbjct: 283 SFLREQLDAVVSDVTIDAVKIGMLGSADIVACVRQWLAEHPMPLVVLDPVMVATSGDRLL 342

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPH-ARTEQEMLEQGRSLLAMGCGAVLMK 176
            P A   +       V ++TPN+PE A LL AP  ART +E L Q           V+ K
Sbjct: 343 DPDAEQAVIE-FAHHVDIVTPNVPELAVLLSAPEPARTFEEALSQAAEFAQKSNTIVIAK 401

Query: 177 GGHLDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           GGHLD + + + +   +G     T PRI T NTHGTGC+LS+ALA          + ++ 
Sbjct: 402 GGHLDGKLANNAVVYPDGRITTITTPRIDTTNTHGTGCSLSSALATRLAAGDTITEAIEW 461

Query: 236 AKSWLSSALAQADTLEVGH--GIGPVHHFHAW 265
              WL+ ++     LEVG   G GP+ HFH  
Sbjct: 462 VSYWLADSIRAGAALEVGTPGGHGPIDHFHQV 493


>UniRef50_A5VNE7 Phosphomethylpyrimidine kinase n=41 Tax=Bacteria RepID=A5VNE7_BRUO2
          Length = 304

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 138/264 (52%), Positives = 181/264 (68%), Gaps = 2/264 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              +TIAG+D SGGAGIQADLK FSALG YG SVI A+  QNTR V +V+ + P  VA Q
Sbjct: 34  PICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQ 93

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+VFSD+ +   KIGM++  + +EA+A  L  +    +VLD VM+AKSGD LLS +A++
Sbjct: 94  IDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSG-PIVLDPVMVAKSGDRLLSETAIS 152

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           +LR +LLP  +L+TPN PEAA LLD   A ++ E  EQGR+LL +G  AVLMKGGH +  
Sbjct: 153 SLRKKLLPLATLLTPNRPEAACLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGA 212

Query: 184 QSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
              D L  R+    R  APRI+T NTHGTGCTLS+A+AA   R+ +    + +A ++L  
Sbjct: 213 ICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGLSRNLSLETALAQAHAYLQG 272

Query: 243 ALAQADTLEVGHGIGPVHHFHAWW 266
           A+  AD+L+VG G GPVHHFHA W
Sbjct: 273 AIRAADSLKVGQGHGPVHHFHALW 296


>UniRef50_Q7P2L0 PHOSPHOMETHYLPYRIMIDINE KINASE n=10 Tax=Fusobacterium
           RepID=Q7P2L0_FUSNV
          Length = 290

 Score =  280 bits (717), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 91/273 (33%), Positives = 152/273 (55%), Gaps = 12/273 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK  N L+IAG+D S GAGIQADLKTF A G YG +VIT+L AQN + V+ +  +  + +
Sbjct: 14  MK--NVLSIAGSDCSAGAGIQADLKTFVANGVYGMTVITSLTAQNPQKVKMLEDVSIEML 71

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++++F  + +   KIGML   +  E + + L +Y+ +N+VLD VM+A SG+ L+   
Sbjct: 72  EKQIEAIFDVMEVSAVKIGMLNSKENGETIYDELLKYKARNIVLDPVMIATSGNSLIREE 131

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-------DAPHARTEQEMLEQGRSLLAMGCGAV 173
               L + L     LITPNL E   ++       +  +  + ++M   G+ +       V
Sbjct: 132 TKKFLVNELFKIADLITPNLDETKEIVKIILNNENIENIDSIEKMKNYGKVIADFTKKWV 191

Query: 174 LMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
           L+KGGHL    + D L  ++        +I + NTHGTGC+LS+A+A+   +  +  D+V
Sbjct: 192 LIKGGHL-SNSAVDILMNKDEIYILEGEKISSNNTHGTGCSLSSAIASNLAKDYSMLDSV 250

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++AK+++  ++  +  ++ G   G V+     +
Sbjct: 251 KKAKNFVLYSIKNS--IDFGEIAGTVNQMGEIY 281


>UniRef50_Q2N848 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Erythrobacter RepID=Q2N848_ERYLH
          Length = 269

 Score =  280 bits (717), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 111/265 (41%), Positives = 145/265 (54%), Gaps = 7/265 (2%)

Query: 1   MKR--INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD 58
           M R     L IAG+D SGGAGIQAD+KT + LG Y  + ITA+ AQN+ GVQ +  ++  
Sbjct: 1   MSRQPPRILAIAGSDSSGGAGIQADIKTITMLGGYAMTAITAVTAQNSVGVQGITPLDGA 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLL 117
           FV  Q+ S   D+ +D  KIGML   DI+ AVA  L+       +VLD VM+A SG PL+
Sbjct: 61  FVGQQIASAIDDIGVDAIKIGMLQNEDIILAVANALEEIDPQVPIVLDPVMVATSGAPLV 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
              AVAT+R RL  +  L+TPNLPE   L      RT + + E    L       VL KG
Sbjct: 121 VQDAVATMRERLFTKARLLTPNLPELELLAG-KQLRTTELVREAAEDLARHYGCDVLAKG 179

Query: 178 GHLDDEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GH  DE+  D L        +F   RI T++THGTGCTLS+A+A L          V+ A
Sbjct: 180 GHTADERIIDVLVPVGGRMAQFDDARIDTRHTHGTGCTLSSAIATLLGHGQPMEHAVRLA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHH 261
           + ++  A+  A     G G GP+ H
Sbjct: 240 RRFVREAIENAP--GFGDGAGPLGH 262


>UniRef50_Q2S369 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=Q2S369_SALRD
          Length = 290

 Score =  279 bits (715), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 111/264 (42%), Positives = 158/264 (59%), Gaps = 4/264 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +  ALTIAG+D  GGAGIQADLK   A G +G S + A+ AQNT  V   + + P  VA 
Sbjct: 4   KPVALTIAGSDSGGGAGIQADLKAMEANGVFGASALAAVTAQNTEEVSRAHDLPPSLVAT 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V  D+ +   K GML+   I+E VA+R+  + ++  V+D VM++K+G  LL   A+
Sbjct: 64  QIDAVVGDMDVKAAKTGMLSAPPIIETVADRVATHDLRPFVVDPVMISKTGFKLLQDEAI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
            TL + LLP  +L+TPN+ EA  L D     T  ++   G +LL  G  AVL+KGGHL  
Sbjct: 124 DTLVNDLLPLATLVTPNVHEAEHLTDV-EIDTPDDLRAAGAALLEYGPDAVLVKGGHLSG 182

Query: 183 -EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            + + D L   E  +RF APRI T++THGTGCT ++A+AA   +  +    V  AK +++
Sbjct: 183 ADDAVDVLVDGETGRRFQAPRIDTEHTHGTGCTYASAIAAHLAKGHDLGAAVDRAKRYVT 242

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
            A+  A  L +GHG GP +HF   
Sbjct: 243 GAIRHA--LPLGHGRGPTNHFFHL 264


>UniRef50_P39610 Pyridoxine kinase n=9 Tax=Firmicutes RepID=PDXK_BACSU
          Length = 271

 Score =  279 bits (715), Expect = 6e-74,   Method: Composition-based stats.
 Identities = 95/264 (35%), Positives = 146/264 (55%), Gaps = 5/264 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRG--VQSVYRIEPD 58
           M    ALTIAG+D SGGAGIQADLKTF     YG + +T +VA +        V+ I+ D
Sbjct: 1   MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAMDPNNSWNHQVFPIDTD 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
            + AQL ++   + +D  K GML   DI+E  A+ ++  Q++NVV+D VM+ K  + +L 
Sbjct: 61  TIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLKNVVIDPVMVCKGANEVLY 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
           P     LR +L P  ++ITPNL EA+ L      +T  +M+E  + + A+G   V++ GG
Sbjct: 121 PEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDMIEAAKKIHALGAQYVVITGG 180

Query: 179 H-LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
             L  E++ D L+  E  +   +  I T  THG GCT SAA+ A   +     + +  AK
Sbjct: 181 GKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTFSAAVTAELAKGAEVKEAIYAAK 240

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
            ++++A+ ++  L     +GP  H
Sbjct: 241 EFITAAIKESFPLN--QYVGPTKH 262


>UniRef50_Q1VWC4 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Flavobacteriaceae
           RepID=Q1VWC4_9FLAO
          Length = 269

 Score =  279 bits (714), Expect = 9e-74,   Method: Composition-based stats.
 Identities = 114/268 (42%), Positives = 166/268 (61%), Gaps = 4/268 (1%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L IAG+D  GGAGIQAD+K+  A GAY  ++ITA+ AQNT GV ++  + P  
Sbjct: 1   MKTYPKLLIIAGSDSGGGAGIQADIKSAGACGAYSATIITAITAQNTLGVNAIEGVSPQM 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +A QL +V  D+  D  KIGML   +++E VA+ LQ Y+ +++VLD VM+A SGDPLL  
Sbjct: 61  IANQLTAVMDDIGADALKIGMLHSKEVIEEVAKHLQHYKAKHIVLDPVMVATSGDPLLQE 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  L  +++PQ  +ITPN+PE   LL     +   E  +  R+L      +VL+K GH
Sbjct: 121 DAIQALMHQIIPQAEVITPNVPEMELLLGET-IKNTTEFSDYARALAEKFKVSVLLKAGH 179

Query: 180 LDDEQSPDWLFTREGEQR--FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           L  ++S D LF  + +Q    ++PRI TKNTHGTGC+LS+ALA+   +  +  D  Q+AK
Sbjct: 180 LKGDKSVDILFNVKTKQITKLSSPRITTKNTHGTGCSLSSALASYLAQGFSLEDASQKAK 239

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAW 265
           +++  A+      ++G G GP+HHF+  
Sbjct: 240 TFIYQAIKAGGDYKLGKGSGPIHHFYKL 267


>UniRef50_B8DSX8 ThiE-ThiD fusion protein n=6 Tax=Actinobacteria (class)
           RepID=B8DSX8_BIFA0
          Length = 516

 Score =  278 bits (713), Expect = 9e-74,   Method: Composition-based stats.
 Identities = 107/263 (40%), Positives = 146/263 (55%), Gaps = 3/263 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LTIA TD SGGAGI ADLKT  A   +G  V+  + AQNT GVQ++  ++P  V 
Sbjct: 255 KLPAVLTIATTDSSGGAGIPADLKTMLANDVFGECVVAGITAQNTTGVQAIAAVDPSIVG 314

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+DSVF D+R    KIG++   + V+ VA +L+ +Q  N+V+D VM+A SG  L +   
Sbjct: 315 AQIDSVFDDIRPTAVKIGVIVGVESVKTVARKLRDHQATNIVVDPVMVATSGSSLAADDT 374

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +A   S L P  ++ITPN+PEA  L   P    + +M      L       VL+KGGH  
Sbjct: 375 IAEEISSLFPIATVITPNIPEAQVLAQMP-IGNQADMETAAVQLAKDYGTCVLVKGGHGV 433

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            +      F       F   RI   NTHGTGCTLS+A+A+   +  +  D V++AK++LS
Sbjct: 434 KDADDVLAFPTGAVTWFEGERIANDNTHGTGCTLSSAIASYLAQGEDLEDAVRDAKAYLS 493

Query: 242 SALAQADTLEVGHGIGPVHHFHA 264
            AL     L +G G GP+ H  A
Sbjct: 494 GALRA--NLNLGKGHGPMDHAWA 514


>UniRef50_B0RGG3 Multifunctional protein thied [includes: thiamine-phosphate
           pyrophosphorylase (Tmp pyrophosphorylase) (Tmp-ppase)
           (Thiamine-phosphate synthase); phosphomethylpyrimidine
           kinase (Hmp-phosphate kinase) (Hmp-p kinase)] n=16
           Tax=Bacteria RepID=B0RGG3_CLAMS
          Length = 752

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 132/269 (49%), Positives = 166/269 (61%), Gaps = 7/269 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A G YG +V+TALVAQNT GV+ ++     F+ AQ
Sbjct: 262 PRVLSIAGTDPTGGAGIQADLKSIAANGGYGMAVVTALVAQNTTGVREIHVPPVAFLRAQ 321

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD+V  DV ID  KIGML    +V+ VA  L   +   VVLD VM+A+SGD LL   A  
Sbjct: 322 LDAVSDDVAIDAVKIGMLGSAAVVDEVAAWLGAVRPPVVVLDPVMVAQSGDALLDADATE 381

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            LR RLLP   ++TPNLPE AALL    A   +  L QGR+L       V++KGGHL  +
Sbjct: 382 ALR-RLLPLADVVTPNLPELAALLGEREADGWEAALAQGRTLATRHGVRVVVKGGHLRVD 440

Query: 184 QSPDWLFTRE------GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
             PD L T               PRI T +THGTGC+LS+ALA L+PR  +W   + EAK
Sbjct: 441 DCPDALVTPGAGGAGPTAHVVDGPRIATTSTHGTGCSLSSALATLQPRRDDWRAALTEAK 500

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +WL+ +LA A+ L VG G GP+ H  A W
Sbjct: 501 AWLTGSLAHAEDLGVGSGAGPLDHLRALW 529


>UniRef50_A6Q7N2 Phosphomethylpyrimidine kinase n=1 Tax=Sulfurovum sp. NBC37-1
           RepID=A6Q7N2_SULNB
          Length = 270

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 105/250 (42%), Positives = 155/250 (62%), Gaps = 1/250 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG DP GGAG+  D+KT  ALG Y  S +TA+ AQN+ GV+SV+   P+ + AQ
Sbjct: 7   PTVLTIAGFDPYGGAGVVMDVKTIHALGGYALSSVTAVTAQNSTGVKSVHNTAPEILRAQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L+ +  D+ +D  KIGMLA+ ++V+++ E +Q+Y ++N+VLDTV+++ SG  L+   AV 
Sbjct: 67  LEVLLDDISVDAVKIGMLADKEVVQSIVEIIQKYDLKNIVLDTVLVSSSGRQLIREDAVE 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            ++  L P V LITPN+PE   L    ++  E E  E  ++   +G  AVL+KGGH + E
Sbjct: 127 VMKKELFPLVDLITPNIPEVNTLQHHTYSGKESETQEVAQAFFDLGVNAVLLKGGHSEAE 186

Query: 184 QSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           ++ D L  R+G    F   RI T +THGTGC LS+A+A    +     ++V  AK +LS 
Sbjct: 187 EAIDHLVQRDGTMESFAHRRIDTTHTHGTGCLLSSAVATGLAKGLEMNESVSGAKDFLSR 246

Query: 243 ALAQADTLEV 252
            L  AD L++
Sbjct: 247 KLEHADELDL 256


>UniRef50_C7R3Y2 Phosphomethylpyrimidine kinase n=1 Tax=Jonesia denitrificans DSM
           20603 RepID=C7R3Y2_JONDD
          Length = 518

 Score =  277 bits (709), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 112/269 (41%), Positives = 151/269 (56%), Gaps = 8/269 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
             I  LTIAGTDP+GGAG+QAD+KT +A G Y  SV+TA+VAQNT GV+    +    VA
Sbjct: 6   SPIRVLTIAGTDPTGGAGVQADIKTITACGGYALSVVTAVVAQNTVGVRCFESVSSSLVA 65

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL +V SD      K+GML +  +   V E  +      +V+D VM+A SGD L++  A
Sbjct: 66  DQLAAVASDTAPAAVKVGMLGDPAVSREVCEFARHL-TVPLVVDPVMVATSGDELVTGVA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              L   LLP  +LITPN+PE A L    HA +++E+  Q R +      AVL KGGH  
Sbjct: 125 REALWE-LLPLATLITPNIPELAVLSGMAHAVSDEELEHQARLVAHKFGVAVLAKGGHRV 183

Query: 182 DEQSPDWLFTREG------EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
            + + D L    G           A R+ T +THGTGC+LS+A+A L  R  +  + V+ 
Sbjct: 184 GDTASDVLIGAPGPGGQCEAVWVHAQRVNTTSTHGTGCSLSSAIATLLGRGYDLPEAVRR 243

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFHA 264
           AK WL+ A+   D + VG G GP+ H  A
Sbjct: 244 AKVWLTQAIRAGDRMAVGTGHGPLDHMWA 272


>UniRef50_Q3ASE2 Phosphomethylpyrimidine kinase n=6 Tax=Chlorobium/Pelodictyon group
           RepID=Q3ASE2_CHLCH
          Length = 275

 Score =  277 bits (709), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 120/272 (44%), Positives = 162/272 (59%), Gaps = 7/272 (2%)

Query: 1   MKRIN-ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MKR    LTIAG+D SGGAGIQADLKTF+AL  YG SVITA+ AQNT+GV  V+ +E   
Sbjct: 1   MKRYTTVLTIAGSDGSGGAGIQADLKTFAALRCYGVSVITAITAQNTQGVSGVFPVENHC 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI--QNVVLDTVMLAKSGDPLL 117
           + AQ +++  D+  D  KIGML     +  +A  L+        ++LDTV+ + SG  LL
Sbjct: 61  LQAQFEALQKDITFDAIKIGMLGSASTITTLAALLRALPTPRPPIILDTVLASSSGMALL 120

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHAR-TEQEMLEQGRSLLAMGCGAVLMK 176
            PSA+A + S+L P  +LITPN+PE A L        T QE+    + L A G  +VL+K
Sbjct: 121 PPSAIACMVSKLFPLATLITPNIPECALLAGKSAVPQTAQEIEAVAKELQAQGAASVLIK 180

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH    +  D L  +E  Q F+AP I T NTHGTGCTLS+A+AA   +     + V +A
Sbjct: 181 GGHGKSNECHDCLLWQERCQWFSAPMIATHNTHGTGCTLSSAIAAFMAKGYPLDNAVLQA 240

Query: 237 KSWLSSALAQADTLEVG---HGIGPVHHFHAW 265
           K++L+SAL      ++G   +G GP+ H    
Sbjct: 241 KNYLNSALQAGAAYQLGMSANGHGPLFHLWEL 272


>UniRef50_C0NXA7 Phosphomethylpyrimidine kinase THI20 n=4 Tax=Leotiomyceta
           RepID=C0NXA7_AJECG
          Length = 488

 Score =  276 bits (707), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 96/272 (35%), Positives = 154/272 (56%), Gaps = 18/272 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ +   FV
Sbjct: 1   MKLKRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVVPVGFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++   DV  D  K+GMLA  +  E VA+ L  +++  VVLD VM++ SG  LL   
Sbjct: 61  RKQINAGLEDVGADVVKLGMLASAETAEMVADTLWHHKVSKVVLDPVMVSTSGSELLPAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDA-----PHARTEQEMLEQGRSLLAMGCGAVLM 175
           AV  ++++LLP  +++TPN+PEA  LL             ++ ++  + +  +G   VL+
Sbjct: 121 AVNIVQTKLLPLTTIVTPNIPEAILLLQGSGAATKDPENLEDAIQIAKQIHTLGPKYVLL 180

Query: 176 KGGHLDDEQSPDWLFTREGEQRFTAPRIMT-KNTHGTGCTLSAALAALRPRHTNWADTVQ 234
           KGGH+           R   +   + RI   KNTHGTGC+L++A+AA   +  +    V+
Sbjct: 181 KGGHMP----------RTCSRSLASSRISCLKNTHGTGCSLASAIAANLAQGMDVVRAVR 230

Query: 235 EAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            A  ++ + +  +  +++G G GP++HFH+ +
Sbjct: 231 AACRFVEAGIRTS--VDMGKGNGPINHFHSVY 260


>UniRef50_Q478V3 Phosphomethylpyrimidine kinase n=15 Tax=cellular organisms
           RepID=Q478V3_DECAR
          Length = 291

 Score =  275 bits (705), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 83/249 (33%), Positives = 134/249 (53%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            L  A +DPS GAGIQADL T ++LG +  + +TA+  Q+T GVQSV+ +  + +  Q  
Sbjct: 14  VLVFAASDPSSGAGIQADLLTLASLGCHPLTALTAVTVQDTVGVQSVHPLAAELLEQQAR 73

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D+ +   KIG+L   + V AVAE +  Y    ++LD V+ +  GD L S   ++ +
Sbjct: 74  TILEDMPVVAFKIGVLGSVENVLAVAEIVSDYPEIPLILDPVLASGRGDDLSSEEIISAI 133

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLPQ +L+TPN PEA  L ++    +E  +    + L+ MG   VL+ G H +  Q 
Sbjct: 134 REMLLPQTTLLTPNAPEARRLAESDEDESEPSIDICAQRLIEMGAQYVLITGTHENTPQV 193

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            + L+  +G  R      +  + HG+GCTL++A+A       +  D V++A+ +   AL 
Sbjct: 194 INTLYGPDGVVRRDEWERLPGSYHGSGCTLASAIAGCIAGGASIEDAVRDAQDYTWQALK 253

Query: 246 QADTLEVGH 254
                 +G 
Sbjct: 254 NGFRAGMGQ 262


>UniRef50_Q31JD4 Phosphomethylpyrimidine kinase n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31JD4_THICR
          Length = 281

 Score =  275 bits (705), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 109/267 (40%), Positives = 160/267 (59%), Gaps = 8/267 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAG+DP GGAGIQADLK+  ALG Y  + ITAL AQN++GV  V     D +  Q
Sbjct: 6   PTVLSIAGSDPYGGAGIQADLKSIHALGGYALTCITALTAQNSQGVAHVVATSSDILNHQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD++  D+++D  KIGMLA  +++  VA+++ +Y ++N+VLDTV+++ SG PLL  SA+ 
Sbjct: 66  LDTLLQDIKVDAVKIGMLANAELINVVADKITQYSLKNIVLDTVLISSSGHPLLEESAIE 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDD 182
            L+ RL P+ ++ITPNLPE   LL        QEM     + L +G  AV+ KGGH L+ 
Sbjct: 126 CLKKRLFPKATIITPNLPEINHLLGTHFHGIAQEMDAIKEAFLKLGAQAVVAKGGHGLET 185

Query: 183 EQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           + + D L         F++PRI T +THGTGC+ S+A+A    +  +    VQ+AK  + 
Sbjct: 186 DLATDVLLQPNHPPMPFSSPRIQTSHTHGTGCSFSSAIATFLAQGNDLTSAVQQAKQQMH 245

Query: 242 SALAQADTLEVG------HGIGPVHHF 262
               Q+++L+        H   P+HH 
Sbjct: 246 LWFGQSESLQFDYQSNLTHRKEPLHHL 272


>UniRef50_A1WTB6 Phosphomethylpyrimidine kinase n=7 Tax=Bacteria RepID=A1WTB6_HALHL
          Length = 271

 Score =  275 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 121/262 (46%), Positives = 158/262 (60%), Gaps = 3/262 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             L IAG+D  GGAGIQADLK   ALG Y C+ ITAL AQNT+GVQ V+ + P F+ AQ+
Sbjct: 9   RVLVIAGSDSGGGAGIQADLKAVMALGGYCCTAITALTAQNTQGVQDVHTVPPGFIRAQI 68

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSAVA 123
            SV +D+  D  K GML +T +++AVA  L        +V+D VM+A+SGD LL+ +A  
Sbjct: 69  RSVLTDIGADCVKTGMLHDTAVIDAVAAELDALAPGVPLVVDPVMVAQSGDRLLAEAAAE 128

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP+ +L+TPNLPEA  LL      TE  + E  R+L   G  AVL+KGGH   +
Sbjct: 129 RLGDVLLPRATLLTPNLPEAEVLLGRSVPATESGLQEAARALRGYGAEAVLVKGGHAPGD 188

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D L T EGE  F + RI T + HGTGCTL++A+AA   R    +D V  A+ +L  A
Sbjct: 189 EVIDCLATPEGEVCFRSRRIETNSNHGTGCTLASAIAAGVARGLPLSDAVPHARDYLQEA 248

Query: 244 LAQADTLEVGHGIGPVHHFHAW 265
           L  A    +G G GPV+H    
Sbjct: 249 LRTAR--GLGGGAGPVNHAFNV 268


>UniRef50_Q8NQH1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=18
           Tax=Actinomycetales RepID=THIED_CORGL
          Length = 763

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 115/261 (44%), Positives = 156/261 (59%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A G YG  V+T+LVAQNT GV +++     F+  Q
Sbjct: 242 PRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTSLVAQNTHGVNTIHTPPLTFLEEQ 301

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L++VFSDV +D  K+GML   D V+ VA  L  ++   VVLD VM+A SGD LL  SA  
Sbjct: 302 LEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEE 361

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           +LR RL   V ++TPN+PE A L D+  A T  E + Q +         V++KGGHL   
Sbjct: 362 SLR-RLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGA 420

Query: 184 QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            + + +   +G   +    R+ T N+HGTGC+LSA+LA       +    ++ +  WL+ 
Sbjct: 421 LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATKIAAGESVEKALEWSTRWLNE 480

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           AL  AD L VG G GPV H H
Sbjct: 481 ALRHADHLAVGTGNGPVDHGH 501


>UniRef50_Q2LST1 Phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase n=2
           Tax=Bacteria RepID=Q2LST1_SYNAS
          Length = 293

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 113/268 (42%), Positives = 159/268 (59%), Gaps = 6/268 (2%)

Query: 1   MKR--INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD 58
           M R     LTIAG+D  GGAGIQADLKT + LG +G SVITAL AQNT GVQ ++ +   
Sbjct: 1   MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPIS 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
           F+  Q D+V +D+ +D  K GML    +V AVA ++++++I+ +V+D V+ AK G  L+ 
Sbjct: 61  FIEQQFDAVATDIGVDAAKTGMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIE 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+ TL S LLP   ++TPN+PEA  + +     +  +M E  R +   G   V++KGG
Sbjct: 121 DEAMETLVSDLLPLAFVVTPNVPEAEVMAEMT-ISSVADMKEAARRIRRFGVPNVIVKGG 179

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           HL  E + D L+       F A RI TK+THGTGCT SAALA          D+V+EAKS
Sbjct: 180 HLPGE-ALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKS 238

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +++  +  A    +G G GP +H    +
Sbjct: 239 YITEVIRYA--WRIGGGHGPTNHAAPLF 264


>UniRef50_D1B7D2 Phosphomethylpyrimidine kinase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B7D2_THEAS
          Length = 271

 Score =  273 bits (698), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 113/263 (42%), Positives = 146/263 (55%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R  A+TIAG+D  GGAGIQADLKTF  L  +G S +TA+ AQN+ GV  V  +    V
Sbjct: 1   MYRGVAMTIAGSDSGGGAGIQADLKTFMGLNVFGVSAVTAVTAQNSMGVYHVENLSVRSV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+  + SD  +   KIGML+  +I+EAVAE L  Y    VVLD VM+++SG  L+   
Sbjct: 61  REQIRCLLSDFPVRAVKIGMLSTGEIMEAVAEELSSYPG-PVVLDPVMVSQSGHSLMDSG 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPH--ARTEQEMLEQGRSLLAMGCGAVLMKGG 178
           A   +R RLLP  SL+TPNLPEA  LL  P     T+ +ML+    LL  GC  VL+KGG
Sbjct: 120 AERAMRERLLPLASLVTPNLPEAERLLGLPPGSIATKGDMLDAANRLLEAGCRGVLLKGG 179

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           HL  +   D L     E  F   RI   N HGTGCTLS+A+AA      +    V   + 
Sbjct: 180 HLPGDDIFDVLICGAEEVLFEDRRIPGGNDHGTGCTLSSAIAAELAAGEDLKTAVTRGRE 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           ++   +     L  G G G ++H
Sbjct: 240 FVRRGMETGVRL--GRGHGCLYH 260


>UniRef50_Q97BE3 Phosphomethylpyrimidine kinase n=3 Tax=Thermoplasmatales
           RepID=Q97BE3_THEVO
          Length = 266

 Score =  272 bits (696), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 95/263 (36%), Positives = 147/263 (55%), Gaps = 4/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQADLKTF++L  +G SVITA+ AQN+  V  +  + P+FV
Sbjct: 1   MPIPKALTIAGSDSGGGAGIQADLKTFNSLSVFGMSVITAVTAQNSYEVSGILPVPPEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  D+++D  K GML  ++I++ V   ++ Y I+ V++D VM++KS   LL   
Sbjct: 61  KLQIDTVAKDIKVDGAKTGMLFSSEIIKVVTGSIKDYSIKPVIVDPVMVSKSNARLLRED 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ +L   LLP+ +++TPN+PEA  L       T ++M      +       VL+KGGH 
Sbjct: 121 AIESLIKYLLPESTIVTPNIPEAEILASM-SISTIEDMKAAAEKIGTEIGLKVLVKGGHF 179

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +     D  +      +F   R  TKNTHGTG TLS+A+ +   +     + +   K ++
Sbjct: 180 NGPPI-DIYYDGSNILKFEGTRYETKNTHGTGDTLSSAILSFLIKGYREQEAIALGKEYV 238

Query: 241 SSALAQADTLEVGHGIGPVHHFH 263
             ++  +     G G G + H+ 
Sbjct: 239 EGSIRNS--FPTGSGFGSLCHWW 259


>UniRef50_C1TP80 Hydroxymethylpyrimidine kinase; phosphomethylpyrimidine kinase n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TP80_9BACT
          Length = 271

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 97/242 (40%), Positives = 144/242 (59%), Gaps = 3/242 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+AL  +G S +TA+ AQN+ GVQ+++ I P+ +  Q+ SV SD  I   K G
Sbjct: 22  IQADLKTFAALRVFGTSALTAVTAQNSLGVQAIHDIPPEIIYEQMKSVLSDFSIGAVKTG 81

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +TD +  V   ++ + +  +V+D VM+A+SGD L+   AV+ ++  LLP  +L+TPN
Sbjct: 82  MLGKTDAIGVVCRAVRDFSVHKLVVDPVMIAQSGDSLIQDDAVSAIKEELLPLATLVTPN 141

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L         + M+    ++  MG  AVL+KGGHL+ E+  D L++     +F 
Sbjct: 142 VPEAERLSGL-EVSDVEGMIAAASAIAGMGPQAVLVKGGHLEGEKVVDVLWSSGKPIKFE 200

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +PRI T+N HGTGCTLSAA+A+           V+  +++L  AL +      G G GP 
Sbjct: 201 SPRIDTENNHGTGCTLSAAIASELAAGCELDLAVERGRAYLMMALERGFKP--GKGYGPT 258

Query: 260 HH 261
            H
Sbjct: 259 GH 260


>UniRef50_C7TG65 Phosphomethylpyrimidine kinase n=51 Tax=Lactobacillales
           RepID=C7TG65_LACRL
          Length = 283

 Score =  270 bits (692), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 98/247 (39%), Positives = 147/247 (59%), Gaps = 4/247 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           +QADLKTF A   +G S++ AL AQNT GVQ+   I  DF+ AQ  S+ +D  I   K G
Sbjct: 23  MQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPGDFIDAQFQSLAADFAIKACKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA+++ V AV   L++     +++D VM+AK G  LL+P AVAT++  LLP   ++TPN
Sbjct: 83  MLADSEHVNAVVRNLKQVNFGPLIVDPVMVAKGGATLLAPEAVATIKQELLPLADVVTPN 142

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREG-EQRF 198
           LPEA  ++  P  + E +M+   +++  +G   V++KGGH  D Q+ D++   +G     
Sbjct: 143 LPEAEIIVGHP-IKREADMIAAAQTIQELGVKNVIIKGGHRQDAQASDFILLADGSSFWV 201

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            +PRI T NTHGTG T SA +AA   +  +    +  AK++L  A+  +  + VGHG GP
Sbjct: 202 RSPRIATGNTHGTGDTFSACIAAELAKGESLKKAIITAKAFLEGAI--SQGIFVGHGHGP 259

Query: 259 VHHFHAW 265
            +H+   
Sbjct: 260 TNHWATL 266


>UniRef50_C6VJ68 Phosphomethylpyrimidine kinase n=4 Tax=Lactobacillus
           RepID=C6VJ68_LACPJ
          Length = 274

 Score =  270 bits (690), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 101/263 (38%), Positives = 148/263 (56%), Gaps = 5/263 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
               TIAGTD  GGAG+ ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q
Sbjct: 5   PQVATIAGTDSGGGAGVMADLKTMQARHVFGTAVVVAVTAQNTLGVQDFMAMPTKLIDEQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             S+ +D+ I   K GMLA+ + V AV E L+R+    + +D VM+AK G  LL+  A+ 
Sbjct: 65  FASLAADLDIRACKTGMLADAEHVHAVVENLKRFDFGPLTVDPVMIAKGGAALLAADAIK 124

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
           T+R  LLP  +++TPNLPEA  L       + Q M++ G SL  +G   V++KGGH D+ 
Sbjct: 125 TVRDELLPLATVVTPNLPEAEQLTG-QSITSNQAMVKAGHSLQGLGADNVIIKGGHGDNP 183

Query: 184 QSPD--WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
              +   L         +APRI T  THGTG TLSA + A   +  + A  ++ AK++++
Sbjct: 184 DLANDFVLLADGTAFWLSAPRIDTVRTHGTGDTLSACITAELAKGRSMAAAIKTAKAYVA 243

Query: 242 SALAQADTLEVGHGIGPVHHFHA 264
             +     ++VGHG GP++H+  
Sbjct: 244 GTIQDG--IQVGHGHGPLNHWAT 264


>UniRef50_B2AXQ5 Predicted CDS Pa_7_11350 n=4 Tax=Sordariomycetes RepID=B2AXQ5_PODAN
          Length = 532

 Score =  270 bits (690), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 97/289 (33%), Positives = 160/289 (55%), Gaps = 26/289 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT GV  ++ +  +F+
Sbjct: 1   MPPGRILVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTLGVHGIHHVPAEFL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+D+V  +     TK GM+A    +EAVAE ++ Y+++ VV+D VM+A +G PLL  +
Sbjct: 61  RKQIDAVGLNCTDCKTK-GMMASAGTIEAVAEVIREYKLKTVVVDPVMVATTGSPLLPNT 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           +++ LR +L+P  +++TPNLPEA  LL              ++    R++ ++G   VL+
Sbjct: 120 SLSLLREKLVPLATVLTPNLPEARLLLADAGFGHLPVEKVSDLEGIARAVGSLGPKWVLI 179

Query: 176 KGGHLD-------------DEQSPDWLFTREGE-----QRFTAPRIMTKNTHGTGCTLSA 217
           KGGH                E+  D L+ R+ +     ++   P   +K+THGTGC+L++
Sbjct: 180 KGGHCPFNGEGMIAAEEGKREKVVDVLWGRDEKGGEVLRQVETPYWESKHTHGTGCSLAS 239

Query: 218 ALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           A+A    +  +    V+ A  ++ + +  A    +G G GP++HFH+ +
Sbjct: 240 AIACNLAKRMDMPQAVEAACRYVEAGIKTAP--GLGKGNGPLNHFHSTY 286


>UniRef50_C6BTQ6 Phosphomethylpyrimidine kinase n=7 Tax=Desulfovibrionales
           RepID=C6BTQ6_DESAD
          Length = 453

 Score =  269 bits (689), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 108/265 (40%), Positives = 150/265 (56%), Gaps = 7/265 (2%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     LTIAG+D  GGAGIQADLK  S  G YG S ITAL AQNT GV  +  + P+F
Sbjct: 1   MKPLPCVLTIAGSDSGGGAGIQADLKAISMAGCYGASAITALTAQNTTGVTGIEAVSPEF 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           VA Q+++V SD+++   K GML    I+ AV E L+  +   +V+D V +A SG  LL  
Sbjct: 61  VALQIETVCSDIKVSAAKTGMLFSAPIIRAVGESLKD-KDFPLVIDPVCVATSGAKLLKD 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            AV  ++  + P   L+TPN+PEA         ++ +++ +    LL MG  AVL+KGGH
Sbjct: 120 DAVEAMKE-IFPLAELLTPNVPEAELFTGM-EIKSREDVFKAIEILLEMGPKAVLVKGGH 177

Query: 180 LDDEQSPDWL-FTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            D   + DWL    +        R+ TKN+HGTGCTLSA +A+   +  +    V++A+ 
Sbjct: 178 FDSVAATDWLGIKGQQPIPLMQQRVKTKNSHGTGCTLSATIASGLAKGYDMVTAVRKAQE 237

Query: 239 WLSSALAQADTLEVGHGIGPVHHFH 263
           +L+ AL     L  G G GP +H  
Sbjct: 238 YLNLALRAGFDL--GEGSGPPNHLA 260


>UniRef50_A0L3K0 Phosphomethylpyrimidine kinase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L3K0_MAGSM
          Length = 260

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 99/259 (38%), Positives = 142/259 (54%), Gaps = 4/259 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               LTIAG+DP  GAG+QADLKT +ALG YG +V+TA+  QN+  V  V+ +E   VAA
Sbjct: 2   LPCVLTIAGSDPCAGAGLQADLKTITALGGYGATVVTAITVQNSVKVSQVHPVEGSLVAA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+ +V SD+ I   K+GML    +VEAV   L  Y    VV DTV+   +G  LL+   V
Sbjct: 62  QMRAVLSDLPIKAIKLGMLGNRGVVEAVLSVLDHYPEIPVVADTVLRGSAGGALLADEDV 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A     LLP+  LITPNL EA  L          ++      L+ +GCG V++ GGHL  
Sbjct: 122 AHFVQHLLPRCHLITPNLDEAQRLTGLEGGVGVADLESLAYRLMGLGCGGVVLTGGHLVG 181

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKN-THGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            +  D L  + G +R+   +I +K   HGTGCTL++A+A    +  +  + V+E  +++ 
Sbjct: 182 NKVVDTLVCKGGIKRWIGEKIASKEGFHGTGCTLASAVALGVAKGLDDFEAVEEGIAYVR 241

Query: 242 SALAQADTLEVGH---GIG 257
             + ++  L  G    G G
Sbjct: 242 QTIRRSIKLGSGQRFLGHG 260


>UniRef50_A4WJ58 Phosphomethylpyrimidine kinase n=3 Tax=Pyrobaculum
           RepID=A4WJ58_PYRAR
          Length = 449

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 98/261 (37%), Positives = 152/261 (58%), Gaps = 6/261 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R  A+TIAG D  GGAGI AD+KTF+A+G +G + +T + AQNT  V+    + P  V
Sbjct: 1   MWR-VAITIAGLDSGGGAGIHADIKTFAAMGVHGTTALTCVTAQNTYEVREAQCLAPSLV 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+ +V+ D+ ID  K GML   +I+E VA  + +     +V+D VM+AKSG PL+S  
Sbjct: 60  RSQIMAVWDDMGIDAGKTGMLGTREIIEEVASTVSKLGF-PLVVDPVMVAKSGAPLISDD 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSL-LAMGCGAVLMKGGH 179
           AV  LR RLLP   ++TPN PEA  L       +E++       +    G   V++KGGH
Sbjct: 119 AVDVLRRRLLPVAKVVTPNRPEAERLTGMK-IASEKDAERAAEYINKEYGTEVVVVKGGH 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L+  ++ D ++ +    +F+ PR+ ++ THGTGC  SAA+AA   +  +  + ++ AK +
Sbjct: 178 LEGAEAVDVVYYKGSFHKFSTPRLESRATHGTGCAYSAAIAAALAKGLDPLEAIKTAKRF 237

Query: 240 LSSALAQADTLEVGHGIGPVH 260
           + +A+    +   G G  PV+
Sbjct: 238 IYTAIKYGVS--RGKGHWPVN 256


>UniRef50_D1NSS6 Phosphomethylpyrimidine kinase n=2 Tax=Bifidobacterium
           RepID=D1NSS6_9BIFI
          Length = 521

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 106/267 (39%), Positives = 149/267 (55%), Gaps = 6/267 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              AL+IA TD SGGAG+  D+KT  A G +   VI A+ AQNT+GV  +  + P  +  
Sbjct: 256 LPAALSIASTDSSGGAGVPVDIKTMMANGVFAECVICAITAQNTKGVTHLEELSPQAIVK 315

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V+ D+     KIGM+   + + AVA+ LQ  +  N+V+D VM+A SG  L++  A+
Sbjct: 316 QIDAVYDDIAPAAVKIGMVPSIEGINAVADGLQANKATNIVVDPVMVATSGAKLINDDAI 375

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDA----PHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
           ATL SRL P  +LITPNLPE   LL+        + E  M + G ++      +VL+KGG
Sbjct: 376 ATLTSRLFPMATLITPNLPETRVLLETIGSSIDPQDEDGMEQAGLAIAQHFGCSVLVKGG 435

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           H   + +   +      Q F   RI   NTHGTGCTLS+A+AA   +     D +  AK 
Sbjct: 436 HGLADANDVLVNADGTTQWFRGERINNPNTHGTGCTLSSAIAANLAKGQTLVDAIANAKR 495

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           +++ AL Q   LE+G G GP  H   W
Sbjct: 496 YITGALRQM--LELGTGSGPFDHAWMW 520


>UniRef50_Q2FLY4 Phosphomethylpyrimidine kinase n=1 Tax=Methanospirillum hungatei
           JF-1 RepID=Q2FLY4_METHJ
          Length = 257

 Score =  267 bits (683), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 91/246 (36%), Positives = 142/246 (57%), Gaps = 4/246 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             ALTIAG+DPSGGAGIQ DLKTF+  G +G +VITAL AQN   V   + ++P+ V  Q
Sbjct: 6   PAALTIAGSDPSGGAGIQMDLKTFAKTGVWGMAVITALTAQNAAQVTGSWPMDPEMVREQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V  D+     K GMLA T+I++AV E + +     +V+D VM++ SG  LL+  A+ 
Sbjct: 66  IIAVLEDLTPGAIKTGMLANTEIIKAVEETVPK--DVPLVIDPVMISTSGYRLLNDDAIC 123

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +  RL+P   LITPN+PEA  +       ++++++  G  ++ +G   VL+KGGH   +
Sbjct: 124 DICERLIPLAHLITPNIPEAEIISQMK-IASDEDVILAGSKIMDLGAKQVLIKGGHGKGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D+L  +EG   F   R+   + HG+GC LSAA+     +  +     ++AK  ++  
Sbjct: 183 DAIDYLIMKEGNISFRHTRL-PYDVHGSGCCLSAAITGYIAQGFDDISCCKKAKDLVTFG 241

Query: 244 LAQADT 249
           +  A  
Sbjct: 242 IRHAYE 247


>UniRef50_B5Y6H9 Phosphomethylpyrimidine kinase n=1 Tax=Coprothermobacter
           proteolyticus DSM 5265 RepID=B5Y6H9_COPPD
          Length = 262

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 91/246 (36%), Positives = 137/246 (55%), Gaps = 3/246 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+ADL TF  L  +G   ITA+ AQN+RGV  V+ I PD V AQ+D+V  D  +   K G
Sbjct: 14  IEADLATFLHLHVFGTVAITAVTAQNSRGVHGVFDIPPDGVRAQIDAVLKDFSVGAVKTG 73

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  + +  VA+ L  Y  + +V+D VM+A+SGD L+   AV  L  +LLP   ++TPN
Sbjct: 74  MLSREETISEVAKALSEYNCKKLVVDPVMVAQSGDSLIFGDAVKALEEKLLPLAFIVTPN 133

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           +PEA  L      ++ ++M +  +++  +G  +VL+KGGHL+++Q  D  +       FT
Sbjct: 134 IPEAQILTGIT-IKSSEDMKKAAKAISKLGPQSVLVKGGHLEEKQLVDLFYYEGEFYTFT 192

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
             +I T + HGTGCTLSAA+ A    +T   + V+ A  +    +      + G G G V
Sbjct: 193 HEKIDTLDHHGTGCTLSAAITAELAANTETVEAVKRAIDYTRLGIEH--RFKGGKGYGCV 250

Query: 260 HHFHAW 265
            H    
Sbjct: 251 GHIFDI 256


>UniRef50_B3QNM3 Phosphomethylpyrimidine kinase n=4 Tax=Chlorobiaceae
           RepID=B3QNM3_CHLP8
          Length = 276

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 112/260 (43%), Positives = 149/260 (57%), Gaps = 3/260 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D SGGAGIQADLKT +A   YG SVITA+ AQ+T GV  V+ I   F+A Q 
Sbjct: 9   TVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQF 68

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++ SD+RID  KIGML      E +A  +       +VLDTV+ + SG  L S +  A 
Sbjct: 69  ETIVSDIRIDAIKIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAA 128

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHART--EQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           ++ RL P VSLITPNLPEA  L       +  ++E+ +    L   G  +VL+KGGH + 
Sbjct: 129 MK-RLFPLVSLITPNLPEATMLTGRNAPPSGGKEEIEQIALELQMQGAPSVLVKGGHWEG 187

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +   D L   E    F+ P+I T NTHGTGCTLS+A+AA        ++ V     +   
Sbjct: 188 KVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVARGIDYTRK 247

Query: 243 ALAQADTLEVGHGIGPVHHF 262
           AL       +GHG GP++HF
Sbjct: 248 ALQAGAGWRLGHGHGPLYHF 267


>UniRef50_B8H441 Phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase n=9
           Tax=cellular organisms RepID=B8H441_CAUCN
          Length = 267

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 112/263 (42%), Positives = 156/263 (59%), Gaps = 3/263 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +   L IAG+D  GGAGIQAD+KT +ALG Y  + ITA+  QNT GV  V+ I  D +AA
Sbjct: 6   KGRVLVIAGSDSGGGAGIQADIKTITALGGYAATAITAVTVQNTLGVTGVHPIPLDVIAA 65

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q  +V  D+  D  K GML +  +VE VA+ L        V+D VM+AK G PLL+ +A+
Sbjct: 66  QARAVLDDIGADAIKTGMLGDAAVVEIVAQALDHAGGVPAVVDPVMVAKGGAPLLAEAAI 125

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             ++S ++P+  L+TPN PEAAAL       T +++   G +LLA+G  AVLMKGGH+  
Sbjct: 126 GAVKSLMIPRAFLLTPNAPEAAALTGL-VVETTEDLRRAGEALLALGARAVLMKGGHVAG 184

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E+  D L T  GE  F   RI T++THGTGCTL++A AA   +     + V +A +++  
Sbjct: 185 ERVVDVLMTPAGETTFEGERIDTRHTHGTGCTLASACAAGLAKGLKLEEAVAQAWNYVHE 244

Query: 243 ALAQADTLEVGHGIGPVHHFHAW 265
           A+ +A     G G GP+ H    
Sbjct: 245 AMLRAP--GFGAGHGPLDHGWTL 265


>UniRef50_A4SX91 Phosphomethylpyrimidine kinase n=2 Tax=Burkholderiaceae
           RepID=A4SX91_POLSQ
          Length = 293

 Score =  266 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 112/275 (40%), Positives = 156/275 (56%), Gaps = 11/275 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    LTIAG+D  GGAG+QADLK  +ALG YG SVITA+ AQNT GV  +  ++ D V 
Sbjct: 10  QIPKVLTIAGSDSGGGAGLQADLKVITALGGYGMSVITAITAQNTLGVTRIQDVDLDVVE 69

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+D+V  D+  D  KIGMLA  +IV  VA+ L+R+ ++ ++LD V+ A SG  L     
Sbjct: 70  AQIDAVLMDIGADIVKIGMLASPEIVRTVAKALRRHGVKRIILDPVLRATSGASLGGDDT 129

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              + + L P  SL+TPNL EA+ LL         +     + LL MG  AVL+KGGHLD
Sbjct: 130 AQAMIAELFPIASLVTPNLEEASLLLG-REISGPNDFKLAAQELLDMGPQAVLIKGGHLD 188

Query: 182 D--EQSPDWLFTREGE--------QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWAD 231
               Q  D+L  R  E        + F   R+ T NTHGTGCTL++A+A       +   
Sbjct: 189 STHTQITDFLMWRSVEDELEVILTKEFKHYRVNTINTHGTGCTLASAIATYLADGHDLLH 248

Query: 232 TVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +V +A +++ + L     L +G G GP+ H H ++
Sbjct: 249 SVAKAIAYVEAGLEAGRFLSIGEGPGPLWHMHDFY 283


>UniRef50_D1Y931 Phosphomethylpyrimidine kinase n=3 Tax=Propionibacterium acnes
           RepID=D1Y931_PROAC
          Length = 569

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 114/261 (43%), Positives = 152/261 (58%), Gaps = 2/261 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDPSGGAG  AD K+  A G Y  +V+T+LVAQNT GV++++    DF+  Q
Sbjct: 61  PRVLSIAGTDPSGGAGTAADTKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQ 120

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  DVRID  K GML   +IV+AVA  L  ++   VV+D VM+A SGD LL+P A A
Sbjct: 121 LAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVVVDPVMVATSGDRLLAPDAEA 180

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R     + ++ITPN+PE A L  +  A T ++ +EQ R   A    AV++K GHL+ +
Sbjct: 181 AMRE-FCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQ 239

Query: 184 QSPDWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +  +   T EG      A R+ T NTHGTGC+LS+ALA          D +     WL  
Sbjct: 240 RVDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHE 299

Query: 243 ALAQADTLEVGHGIGPVHHFH 263
           A+     L VG G GPV H H
Sbjct: 300 AIQYGSALNVGKGHGPVDHSH 320


>UniRef50_C7MH55 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7MH55_BRAFD
          Length = 599

 Score =  265 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 103/254 (40%), Positives = 158/254 (62%), Gaps = 2/254 (0%)

Query: 8   TIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSV 67
           +IAGTDP+GGAG  ADLK+ +A G YG +V+TA+VAQNTRGV+ ++    + +AAQL +V
Sbjct: 3   SIAGTDPTGGAGTAADLKSITAAGGYGMAVVTAVVAQNTRGVRDIHVPPAEVLAAQLTAV 62

Query: 68  FSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRS 127
             DV ++  K GML   ++++ VA  +  +  + +V+D VM+A SGD LL P A   +  
Sbjct: 63  SDDVELEAVKTGMLGTVEVIDTVAAWVAAHPPRVLVVDPVMVASSGDRLLEPEAEQAMI- 121

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPD 187
           R   + +++TPN+ E A L  +P A TE+E L Q  +  A    +V++K GHL+D +  +
Sbjct: 122 RFCARATVVTPNIDELAVLTGSPRASTEEEALAQATAWTARTGASVIVKTGHLEDREVTN 181

Query: 188 WLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
                +G ++R  + R+ T +THGTGC+L+AALA       + A  ++ A +WL  A+A 
Sbjct: 182 TWVAPDGAQRRARSTRVDTTSTHGTGCSLAAALATRLGAGHSPAAALEWATAWLHEAIAH 241

Query: 247 ADTLEVGHGIGPVH 260
             +L+VG G GPV 
Sbjct: 242 GASLQVGAGHGPVD 255


>UniRef50_UPI00005103C2 phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI00005103C2
          Length = 288

 Score =  265 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 133/278 (47%), Positives = 160/278 (57%), Gaps = 18/278 (6%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   AL+IAGTDPSGGAGI ADLKTF+A G  G + ITALVAQNT GV  VY I+ DFV+
Sbjct: 4   RPPIALSIAGTDPSGGAGIHADLKTFTARGVLGTTAITALVAQNTHGVSRVYGIDDDFVS 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QLDSV +D+ +D TK GML    +VE V  R  + Q+    +D VM+A SG  L    A
Sbjct: 64  DQLDSVLNDMPVDATKSGMLGSRSLVELVVARAAQGQLGFYTVDPVMVATSGHRLHEVDA 123

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLD--APHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           V  +R  LLP   LITPNLPEAA L+    P A+  QEML Q R L+  G  AVL+KGGH
Sbjct: 124 VTAVRDHLLPVSDLITPNLPEAALLIGDDEPVAKNPQEMLVQARQLVHRGPRAVLLKGGH 183

Query: 180 LDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRP-----------RHT 227
             +    D L T EG    FT PR+ T NTHGTGCTLSAA+ A                 
Sbjct: 184 AIEGDVADVLVTAEGTVTEFTHPRVETPNTHGTGCTLSAAITAEVAVLKRARAVDDVSSD 243

Query: 228 NWADTVQEAKSWLSSALAQADTLEV---GHG-IGPVHH 261
              + V  A ++L+ AL  A   +V     G  GPV H
Sbjct: 244 LLHEAVDNALNYLARALKSAANWQVSFDPKGAHGPVDH 281


>UniRef50_Q1INF7 Phosphomethylpyrimidine kinase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1INF7_ACIBL
          Length = 254

 Score =  264 bits (675), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 90/260 (34%), Positives = 133/260 (51%), Gaps = 7/260 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               L+IAG DPS GAGI AD+KT +A   Y  + ITA+  Q T  V +V  +  + V  
Sbjct: 1   MPIVLSIAGYDPSSGAGITADVKTAAAHECYAITCITAVTVQTTEKVFAVEPLRAEIVRD 60

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
            L  +  D+     +IGML   ++ E VA+ L+  +++NVVLD V+ + SG  L+     
Sbjct: 61  TLYELVRDMPPAAVRIGMLGSGEVAEVVADFLETTRLRNVVLDPVLRSTSGAALIDERGE 120

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             +R+RLL  V + TPN  EA  L +      E       R L   GC AV++ GG  +D
Sbjct: 121 QVIRARLLKAVDVCTPNEAEARVLAEC-----EASPEGLARELHRKGCPAVVITGGERED 175

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
             S D L   + ++   A +I ++ THGTGC  + A+A          + V EAK ++  
Sbjct: 176 --SGDLLSFGDQQEWLRAEKIRSRATHGTGCAFATAIACNLALGRQLREAVVEAKFYVRR 233

Query: 243 ALAQADTLEVGHGIGPVHHF 262
           A+       +GHG GP++HF
Sbjct: 234 AITLGSDEPLGHGRGPMNHF 253


>UniRef50_C5FQ29 Thiamine-4 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FQ29_NANOT
          Length = 492

 Score =  263 bits (672), Expect = 5e-69,   Method: Composition-based stats.
 Identities = 97/284 (34%), Positives = 144/284 (50%), Gaps = 29/284 (10%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD +  +A G Y  +  TAL AQNT GVQ ++ I  +FV
Sbjct: 1   MGLKRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTALTAQNTLGVQDIHVIPTEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+ +   DV  D  KIGMLA  +    VAE L+ +++ ++ LD          LL P 
Sbjct: 61  RKQIRAGLEDVGADGVKIGMLASMETAVMVAEELKAHKVPSITLDP---------LLPPD 111

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           AV  +R  LLP  +++TPN+PEA  LL     D        + +   +++  +G   +L+
Sbjct: 112 AVKAVRENLLPITTVLTPNIPEAVLLLRDSGVDVKEPGNLDDAIALAKNIHQLGPKHILL 171

Query: 176 KGGHL-------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL             D     D L+         A    +KNTHGTGC+L++A+AA 
Sbjct: 172 KGGHLPLNAQRQKPTSDEDAAIVVDILYDGVEVTLIEANFSRSKNTHGTGCSLASAIAAN 231

Query: 223 RPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
                     V+EA  ++ + +  +  L  G G GP++HFH+ +
Sbjct: 232 LASEMEMTRAVREACRYVEAGINTSTDL--GKGNGPINHFHSLY 273


>UniRef50_Q040Q3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=48
           Tax=Lactobacillales RepID=Q040Q3_LACGA
          Length = 278

 Score =  263 bits (672), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 100/266 (37%), Positives = 145/266 (54%), Gaps = 6/266 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           + I ALTIAG D  G AG+ ADL  F A G YG  ++TA VA N++G+ +   +  DF+ 
Sbjct: 10  EHIEALTIAGHDSDGSAGMPADLHAFYARGVYGMGLLTAAVAGNSQGIFAQQLMPLDFIQ 69

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q D +  D +I   K GMLA  DI+  VA+ L+ YQ+QN+VLD V++ K G  LL+  A
Sbjct: 70  KQFDVLNDDFKIKAVKTGMLANKDIINVVAKNLEHYQMQNIVLDPVIITKHGATLLADDA 129

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
                 +L+P  ++ITPN  EA  L      + E E+ +  + L  MG   VL+KG H +
Sbjct: 130 YQAFLKKLVPLATIITPNFFEAQKLTGL-ELKNESEIKQGAKMLQKMGAKNVLIKGSHHN 188

Query: 182 DEQ--SPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           D+Q    D+L   +G ++    P   T   +GTG TLSA +AA   +  +    V+ AK 
Sbjct: 189 DKQTEVKDYLLLEDGSDEWLIKPYFKTDRVNGTGDTLSAVIAAELAKGNDVKTAVKIAKD 248

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
           +   AL+    + VG   GP++H  A
Sbjct: 249 FTYEALSH--PINVGAKYGPINHLAA 272


>UniRef50_D1JA17 Phosphomethylpyrimidine kinase n=1 Tax=uncultured archaeon
           RepID=D1JA17_9ARCH
          Length = 438

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 104/255 (40%), Positives = 148/255 (58%), Gaps = 8/255 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR   +TI G+D SGGAGIQAD+KTFSAL  +G SV+TA+ AQN+ GVQ++  +    V
Sbjct: 1   MKR--VMTIGGSDCSGGAGIQADIKTFSALAVHGTSVLTAITAQNSDGVQAIQEVPVKIV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV SD+ +D  K GML   +I+   A +L+RY     VLD VM A +G  LL  +
Sbjct: 59  EQQLESVMSDIAVDYAKTGMLYSAEIIAVAATQLKRY-GVPFVLDPVMKAGAGGILLDDN 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL   L+P  +++TPN+PEA+ +      R  ++       +  MG  AV++KGGHL
Sbjct: 118 ALNTLIELLIPICAVVTPNVPEASIISGL-EIRNIEDAKLAALKINDMGASAVIIKGGHL 176

Query: 181 DDE----QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           + E    ++ D ++  E E+  T+     K  HG GCT SAALAA   + TN  D    A
Sbjct: 177 EHEIAAGKATDLIYDGEFERISTSMIKQGKIVHGAGCTFSAALAAELAKGTNLHDAATSA 236

Query: 237 KSWLSSALAQADTLE 251
           K ++  A+   + L 
Sbjct: 237 KKFVYDAILCGEKLP 251


>UniRef50_Q03NS0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=21
           Tax=Bacteria RepID=Q03NS0_LACBA
          Length = 272

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 97/262 (37%), Positives = 144/262 (54%), Gaps = 5/262 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAGTD  GGAGI ADLKT  A   +G +V+ A+ AQNT GVQ    +    +  Q
Sbjct: 7   PQTLTIAGTDSGGGAGIMADLKTMQACQVFGAAVVVAVTAQNTLGVQDFMALPQKLIDEQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             S+ +D++I   K GMLA+   V  V E L++Y    + +D VM+AK G  LL+  AV 
Sbjct: 67  FASLAADLKIRACKTGMLADAAHVHGVVENLKKYDFGLLTVDPVMIAKGGAALLADDAVT 126

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--LD 181
           T+R  L+P   ++TPNLPEA  L         + M     +L  +G   V++KGGH    
Sbjct: 127 TVRDELVPLADVLTPNLPEAERLTGLT-ITDNRGMEAAAMALQDLGAKNVVIKGGHEATP 185

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           D+ S   L         +A R+ T  THGTG TLS+ + A   +  ++   ++ AK +++
Sbjct: 186 DQASDFVLLVDGRSFWLSAARMDTVRTHGTGDTLSSCITAALAKGEDFETAIRIAKDFVT 245

Query: 242 SALAQADTLEVGHGIGPVHHFH 263
           +A+  A+ + VG+G GP++H+ 
Sbjct: 246 AAI--ANPIAVGNGHGPLNHWA 265


>UniRef50_D2V558 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2V558_NAEGR
          Length = 538

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 94/256 (36%), Positives = 140/256 (54%), Gaps = 13/256 (5%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADL TF A   +G S ITAL AQNT GVQ V+ +  +F+A Q+DSV SD+ I + K 
Sbjct: 280 GIQADLNTFHAHHLFGTSAITALTAQNTLGVQGVFPVSAEFLAKQIDSVMSDINIVSVKT 339

Query: 79  GMLAETDIVEAVAERLQRY----QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           GML  ++++  V E+L+ Y        VV+D VM++ SG  LL   AV  L     P  +
Sbjct: 340 GMLYSSELIRVVIEKLKHYRELNPNIKVVVDPVMVSTSGHNLLKDEAVDALVREFFPMAT 399

Query: 135 LITPNLPEAAALLDAPH----ARTEQEMLEQGRSLLA-MGCGAVLMKGGHL-DDEQSPDW 188
           LITPN+PEA  +L+         T +   +  +++    G   VL+KGGHL + E + D 
Sbjct: 400 LITPNIPEAERILELTDSPFKITTVELSKKAAKTISETFGIRNVLVKGGHLINSEYAVDI 459

Query: 189 LF--TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           L+    +      A  I + NTHGTGC+L+AA+A+     +   D V+ +K ++ +A+ +
Sbjct: 460 LYESEADRFVSLHANFIQSNNTHGTGCSLAAAIASNLALGSTLEDAVRRSKLYVLNAIVR 519

Query: 247 ADTLEVGH-GIGPVHH 261
                    G G ++H
Sbjct: 520 GFNPSQNQTGHGTLNH 535


>UniRef50_C2CTG3 Multifunctional thiamine-phosphate
           pyrophosphorylase/synthase/phosphomethylpyrimidine
           kinase n=1 Tax=Gardnerella vaginalis ATCC 14019
           RepID=C2CTG3_GARVA
          Length = 565

 Score =  261 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 112/274 (40%), Positives = 149/274 (54%), Gaps = 12/274 (4%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IAGTDP+GGAGIQADLK+ +A   +   V T LVAQNT GV+ VY    DF+ AQ
Sbjct: 37  PRVLSIAGTDPTGGAGIQADLKSITASHGFAMCVTTNLVAQNTCGVREVYTPPTDFLQAQ 96

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L++VF DV ID  KIGML +   +  V + L+ + +  VVLD VM+A SGD LL  SA  
Sbjct: 97  LEAVFDDVTIDAVKIGMLGDKSYISLVQDWLKNHPVPVVVLDPVMVATSGDRLLEKSAED 156

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            +R    P   +ITPN+PE A L D   A   +E   Q     A     V++KGGHL  E
Sbjct: 157 AMRE-FAPLADVITPNIPELAVLCDKQPASNFEEAYAQASEWCAKNNTIVIVKGGHLTSE 215

Query: 184 QSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPR----HTNW------ADT 232
            + + +   +G +     PR+ T  THGTGC+LS++LA                   AD 
Sbjct: 216 DAGNTVVFPDGHRVHVPCPRVDTTTTHGTGCSLSSSLATRIGLALREGKKLSDYSTVADA 275

Query: 233 VQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +  +  WL+ A+A    L VG G GPV+H    +
Sbjct: 276 LAWSSRWLNEAIACGKDLHVGKGHGPVNHAARNY 309


>UniRef50_D1ZB20 Whole genome shotgun sequence assembly, scaffold_16 n=1
           Tax=Sordaria macrospora RepID=D1ZB20_SORMA
          Length = 536

 Score =  260 bits (665), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 98/294 (33%), Positives = 154/294 (52%), Gaps = 34/294 (11%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L IAG+D SGGAG++AD K  +A G Y  +  TAL AQNT+GV  ++ +  DF+  Q
Sbjct: 12  PRVLVIAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTKGVYGIHEVPVDFLRKQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V  DV +D  K GMLA T  +EAVA+ +   +++ +V+D VM+A +G  LL  SA  
Sbjct: 72  IDAVVEDVGVDVVKTGMLASTSTIEAVAQAIHDNKLKTLVVDPVMIATTGAELLPNSASR 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
            LR +LLP  +++TPN+PEA  LL     D    ++  ++ E    +  +G   VL+KGG
Sbjct: 132 ALREKLLPLATILTPNVPEANTLLLEAGHDKHLVQSVADLEEIALKVQKLGSKWVLVKGG 191

Query: 179 HL-------------DDEQSPDWLFTRE--------------GEQRFTAPRIMTKNTHGT 211
           H              + E   + L                     +   P   ++NTHGT
Sbjct: 192 HSPFRRDGTEAKTEDEKEIVVNVLVGPAAEGTKRDVEGEEKLQVVKIEMPYQRSRNTHGT 251

Query: 212 GCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           GC+L++A+A+   +  +    V+    ++ +A+  A    +G G GP++HFH+ 
Sbjct: 252 GCSLASAIASNLAKGMDMVSAVKAGIRYVDAAIRTAP--GLGQGNGPLNHFHSV 303


>UniRef50_Q1ASC3 Phosphomethylpyrimidine kinase type-2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=Q1ASC3_RUBXD
          Length = 264

 Score =  259 bits (663), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 106/265 (40%), Positives = 144/265 (54%), Gaps = 7/265 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR   ++IA +D   GAGIQADLK F   G YG + + A+ AQNT GV+S++   P   
Sbjct: 1   MKR--VMSIATSDSGAGAGIQADLKAFLRCGVYGTTALVAITAQNTVGVRSIFPFPPRVA 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+++V  D+  D  K GML   +I+ AVA  ++R  I N+V+D VM+A+SG  LL   
Sbjct: 59  VDQIEAVVEDIGADAAKTGMLFNAEIISAVAGAVRRLGIPNLVVDPVMVAESGAKLLKDE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AVAT +  L P  ++ITPN+ EA ALL A     E  + E    L + G GAV++ GGH 
Sbjct: 119 AVATYKQELFPLAAVITPNINEAFALLGAEV--DEGRVREAAAELRSFGSGAVIITGGHT 176

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D L+  E       P   ++NTHG GCT SAALA+   R     +  + A+   
Sbjct: 177 AS--GADLLYDGERFLEIEGPTYGSENTHGAGCTHSAALASFLARGLGLEEAARRAREVA 234

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           S A+      E+G G GPVH   A 
Sbjct: 235 SEAVRYGLG-EIGSGAGPVHALGAV 258


>UniRef50_B4D0W4 Phosphomethylpyrimidine kinase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0W4_9BACT
          Length = 274

 Score =  259 bits (663), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 108/268 (40%), Positives = 147/268 (54%), Gaps = 9/268 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D S GAG+QADLKT SALG YG + IT +VA+    V ++  IEP  VA Q
Sbjct: 3   PVGLTIAGSDNSAGAGVQADLKTMSALGVYGVTAITCVVAEVPGKVSAIQAIEPRIVAEQ 62

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-----IQNVVLDTVMLAKSGDPLLS 118
           +  +F    I   K GML   +I+E V + L+  +        +V+D VM+A SGDPLL 
Sbjct: 63  IRLLFEAFPIGALKTGMLYSCEIIETVCDTLRGCREPMPQPPPIVVDPVMVATSGDPLLQ 122

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+A  R RL P  +LITPNL E   LLD     +  EM   G+ L+A    A L+KGG
Sbjct: 123 RDAIALYRERLFPMATLITPNLDEVRTLLD-REVTSVAEMRTAGQELVATYGRAFLIKGG 181

Query: 179 HLDDEQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           HL    + D L   +G  Q F+AP +   +THGTGCT +AA+ A   +  + ++   EAK
Sbjct: 182 HLRLNPAIDLLCAPDGGVQEFSAPFVPGVSTHGTGCTYAAAITAGLAKGLSLSEAASEAK 241

Query: 238 SWLSSALAQADTLEV--GHGIGPVHHFH 263
            +L++ +A         G     +HHF 
Sbjct: 242 QYLATTVAHFLRWPREDGRTTDALHHFW 269


>UniRef50_Q21NU7 Phosphomethylpyrimidine kinase n=1 Tax=Saccharophagus degradans
           2-40 RepID=Q21NU7_SACD2
          Length = 282

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 113/268 (42%), Positives = 159/268 (59%), Gaps = 4/268 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L+IA +D  G AGIQAD+KT  AL AY  + ITA+ AQN+ GV +++ +  + +
Sbjct: 1   MTPTAILSIAASDSFGAAGIQADIKTAMALHAYCATAITAVTAQNSLGVAAIHPVPANIL 60

Query: 61  AAQLDSVFSDVRID---TTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPL 116
           +AQ  +             KIGML   + + AV   +Q+      VV+DTV+ A SG  L
Sbjct: 61  SAQFTAAAQGFLPARLGAIKIGMLGHAEALPAVVSFVQQLAGAIPVVVDTVLNASSGAVL 120

Query: 117 LSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
           L PSAV   R  LLP  +LITPNL EAA LLDAP A +E +  EQ ++LL +GCGAVL+K
Sbjct: 121 LPPSAVRAYRESLLPLATLITPNLHEAALLLDAPLATSEAQQREQAQALLQLGCGAVLLK 180

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH +   + D+L T  GE RF++ +I T N+ GTGC+L+AA+A    +       V+ A
Sbjct: 181 GGHFEGNSASDYLVTPHGEARFSSSKIQTNNSRGTGCSLAAAIAVGIAQGQPLEQAVEAA 240

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHA 264
           K+++S+AL  A   ++  G GP+ H   
Sbjct: 241 KNYISAALQGAVGWQLAQGSGPICHGAN 268


>UniRef50_Q1Q449 Strongly similar to phosphomethylpyrimidine kinase n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q449_9BACT
          Length = 276

 Score =  258 bits (660), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 100/257 (38%), Positives = 146/257 (56%), Gaps = 8/257 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            ALTIAG+D  GGAGIQAD+KT +ALG Y  + ITAL AQNT G+ +VY I   FVA Q+
Sbjct: 10  KALTIAGSDSIGGAGIQADMKTIAALGGYAATAITALTAQNTLGIHAVYEIPASFVARQI 69

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           D+V SD   D  K GML   DI+E VA RL+ Y +  VV+D VML+K+G  LL+  A+  
Sbjct: 70  DAVVSDTGADIVKTGMLYSKDIIETVASRLKHYALSPVVVDPVMLSKNGAALLAEDAIPA 129

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL---- 180
           L S+L P   ++TPN+PEAA +      +   +  +  + +  +G   VL+KGGH     
Sbjct: 130 LISQLFPLAFIVTPNIPEAAHISGIK-IQNITDAEKAAKYIHKLGPANVLIKGGHALHSS 188

Query: 181 ---DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
                    D L+T +         +  K+ HGTGC  ++A+AA   +    A+ V++AK
Sbjct: 189 DIKSSNTVIDILYTGKSFAYIEGEYLPAKHVHGTGCVYASAIAAYLAKGCGIAEAVRQAK 248

Query: 238 SWLSSALAQADTLEVGH 254
            ++   + ++ +   G+
Sbjct: 249 KFVVLCIKKSFSPGRGY 265


>UniRef50_O26711 Transcriptional regulator n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=O26711_METTH
          Length = 253

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 99/260 (38%), Positives = 140/260 (53%), Gaps = 14/260 (5%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           + AL+IAG DPSGGAGI AD+KTFSALG YG  VITAL AQN   V  +  + P FV  Q
Sbjct: 1   MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           LD V  D+ +   K GML   +IVEAVAE+++ Y    V++D VM+A SG  L   + V 
Sbjct: 61  LDLVMEDLPVVHAKTGMLYSAEIVEAVAEKVREY-GLRVIVDPVMVAASGGELSEGNFVR 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            LR  LLP+  ++TPN+ EA  L D P   T  + +   R +  +    V++ GGHL   
Sbjct: 120 ALRRHLLPEALIVTPNVAEAERLSDIP-IGTVDDAIRAARVIGEL--CDVIITGGHLGGR 176

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
                L   +  +      + ++NTHG+GC+ SAA AA   R  +  + ++ A  ++  A
Sbjct: 177 SVI--LIDGD-VEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREA 233

Query: 244 LAQADTLEVGHGIGPVHHFH 263
           +            G ++ F 
Sbjct: 234 IRHGH-------HGTLNQFW 246


>UniRef50_UPI00017450E5 phosphomethylpyrimidine kinase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI00017450E5
          Length = 269

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 106/263 (40%), Positives = 144/263 (54%), Gaps = 4/263 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
                L+IAG+D SGGAGIQADLKTF+ALG YG + IT++VA+    V S+  +EPD + 
Sbjct: 4   SLPVVLSIAGSDCSGGAGIQADLKTFTALGCYGMTAITSVVAETPAVVDSIQLLEPDIIG 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQ--RYQIQNVVLDTVMLAKSGDPLLSP 119
           AQ+  +   + +   K GML     +EAV E  Q        +V+D VM+A SG  LL  
Sbjct: 64  AQIRVLAKGMPLAAAKTGMLGGRKQIEAVVEAWQPMAQAEVPLVVDPVMVATSGGRLLER 123

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A  TL   LLP   +ITPNL EAA LL A    +  EML   ++L  +   AVLMKGGH
Sbjct: 124 DAEETLIGHLLPLARVITPNLDEAAVLLGAA-ITSRGEMLSAAQTLAKIHGVAVLMKGGH 182

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L  + +PD L      + +   RI   +THGTGCT SAA+AA         + V   K +
Sbjct: 183 LAGDAAPDLLVDGTLVRWYEGERISGVHTHGTGCTYSAAIAAGLGSGLGLEEAVALGKKF 242

Query: 240 LSSALAQADTLE-VGHGIGPVHH 261
           +++A+ Q    +  G  I  ++H
Sbjct: 243 VTAAIRQHFRWQHDGAEIDALNH 265


>UniRef50_B5YFN2 Phosphomethylpyrimidine kinase n=1 Tax=Thermodesulfovibrio
           yellowstonii DSM 11347 RepID=B5YFN2_THEYD
          Length = 254

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 80/253 (31%), Positives = 136/253 (53%), Gaps = 5/253 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   ALTI  +DP+ GAGIQ DLK F +L  YG S++TA+ AQ+T    SV+ +  + +
Sbjct: 1   MK--IALTIGASDPTSGAGIQMDLKVFHSLEVYGLSILTAVTAQSTIEFSSVFPLPEEII 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q +++  D++   TKIGM+   +  + V   ++   I+N+V+D VM +  G  LL  +
Sbjct: 59  NSQFETLLKDLKPHGTKIGMIYSKEAFQCVISNIKNLNIKNLVIDPVMTSTLGAKLLENN 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL+  L+P    +T N+PEA AL +       +++ E  + L  MG    ++KGGH 
Sbjct: 119 ALKTLKEELIPLSMAVTANIPEAEALTELK-IERIEDLYEASKQLYQMGTKFAIIKGGHF 177

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           + +++ D L+  +   +    +I     HGTGC  S+A      +  N  +  + +K ++
Sbjct: 178 E-KKAIDILYDGKNFYKIDGKKI-PGQFHGTGCAFSSAFVCFLCKGYNPLEAFKASKDFV 235

Query: 241 SSALAQADTLEVG 253
             A+  +  L  G
Sbjct: 236 RKAIENSLKLGQG 248


>UniRef50_A8YTJ6 Phosphomethylpyrimidine kinase n=18 Tax=Lactobacillales
           RepID=A8YTJ6_LACH4
          Length = 270

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 96/264 (36%), Positives = 137/264 (51%), Gaps = 5/264 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              A+TIAG D  G AG+ ADL  F   G YG  ++TA VA NT G+ +   +  DF+  
Sbjct: 5   PKIAVTIAGNDSDGSAGMPADLHAFYDRGVYGMGLMTAAVAGNTTGIFAQQIMPVDFIQK 64

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q D +  D +I   K GMLA  +I++ VA+ L++Y +  +VLD V++ K G  LL   A 
Sbjct: 65  QFDVLNDDFKISAAKTGMLANKEIIDCVADNLEKYDMGKIVLDPVIITKHGATLLDDDAY 124

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
            T   +LLP   +ITPN  E   L        ++E+    + L  MG   VLMKG H  D
Sbjct: 125 QTFLDQLLPLADVITPNFYEQQKLTGMK-LENKEEIHAGAKKLQEMGAKNVLMKGRHDAD 183

Query: 183 E-QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           + +  D L T +G    FT P   T   +GTG TLSA +AA   +  +  D V+  K + 
Sbjct: 184 QAEVADILLTEDGNFHEFTKPHFKTDRVNGTGDTLSAVIAAELAKGKSIIDAVKIGKDFT 243

Query: 241 SSALAQADTLEVGHGIGPVHHFHA 264
             A++    + VG   GP++H+ A
Sbjct: 244 YEAISH--PINVGSKWGPINHWAA 265


>UniRef50_Q9ZL00 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=11
           Tax=Helicobacter pylori RepID=THID_HELPJ
          Length = 269

 Score =  256 bits (655), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 108/269 (40%), Positives = 152/269 (56%), Gaps = 8/269 (2%)

Query: 1   MKR-INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK     L+IAG+D  GGAGIQADLK F   G +G SVIT + AQNT+GV  VY +  + 
Sbjct: 1   MKVYPQVLSIAGSDSGGGAGIQADLKAFQTFGVFGTSVITCITAQNTQGVHGVYPLSVES 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V AQ+ ++  D  I   K+G L    I+E VA  L+       VLD VM+AK+G  LL  
Sbjct: 61  VKAQILAIRDDFSIKAFKMGALCNAQIIECVANALETCDFGLCVLDPVMVAKNGALLLEE 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+ +L+ RLLP+ +L+TPNLPE  AL     AR ++   +    L  +G    ++KGGH
Sbjct: 121 EAILSLKKRLLPKTNLLTPNLPEVYALTGV-QARDDKSASKAMGVLRDLGVKNAVIKGGH 179

Query: 180 LD---DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
            +    E S DW+F  + E   +A R  TKNTHGTGCTLS+ +  L  +  +  + + +A
Sbjct: 180 TEHFQGEFSNDWVFLEDAEFILSAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAITKA 239

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           K  L+  +     L +GHG GP++   + 
Sbjct: 240 KELLTIIIQN--PLNIGHGHGPLN-LWSI 265


>UniRef50_Q2NFK8 ThiD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NFK8_METST
          Length = 259

 Score =  256 bits (654), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 79/249 (31%), Positives = 133/249 (53%), Gaps = 7/249 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +  ++TIAG DPSGGAGI AD KTF A G Y   V+TA+ AQN   V  +  ++ D +
Sbjct: 6   MNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLI 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +++D + S   I   K GML   DI++ V+ +++ Y ++ VV D VM+++SG  L   S
Sbjct: 66  ESEIDEILSVYPIRYIKTGMLYSGDIIKLVSRKIKEYDLRAVV-DPVMVSESGGDLTGNS 124

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  +   L+    +ITPN+ EA  L +     +E++M+     L      +V++ GGH+
Sbjct: 125 FIEYMNKYLVKNSFIITPNIHEAEKLSN-KTITSEEDMISVAEKLSK--DNSVVITGGHM 181

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D L+  +   R     I + NTHGTGCT S+A+ +      N  ++ +++  ++
Sbjct: 182 QGN---DILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFI 238

Query: 241 SSALAQADT 249
            +++     
Sbjct: 239 RNSIKYGFN 247


>UniRef50_Q7M9P0 PHOSPHOMETHYLPYRIMIDINE KINASE n=1 Tax=Wolinella succinogenes
           RepID=Q7M9P0_WOLSU
          Length = 261

 Score =  255 bits (653), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 91/262 (34%), Positives = 140/262 (53%), Gaps = 7/262 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D SGGAGIQAD+KT  A G +  + +T + AQNT GV+    +    V
Sbjct: 1   MK--VVLTIAGSDSSGGAGIQADIKTAEAFGCFSATALTVITAQNTLGVREAMPLGASLV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSP 119
            +Q+++V  D  ++  KIGML +T+ +  V E L +      VVLD V ++++G  LL  
Sbjct: 59  RSQIEAVMEDFSVEAIKIGMLYDTETILGVGEFLIQNALKIPVVLDPVAISQAGSKLLLD 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+ +L   L P  +++TPNL E     +     T + + E+G         A ++K   
Sbjct: 119 EAIRSLAD-LFPLATVVTPNLKETELFWNLDQEPTLEILRERGVEFARERGVAFVVKNL- 176

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             +++S D+L   EG   F  P +    +HGTGC+ S A+A L     +  + V+EAK +
Sbjct: 177 RKEDRSVDYLIQEEGIASFCTPYVKNGQSHGTGCSFSMAIACLLALGLSLPEAVKEAKDY 236

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+ +A  L  G G GP+ H
Sbjct: 237 IYKAMLEAPFL--GRGAGPILH 256


>UniRef50_Q0RDL7 Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase);
           hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)
           n=10 Tax=Actinomycetales RepID=Q0RDL7_FRAAA
          Length = 291

 Score =  255 bits (653), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 106/259 (40%), Positives = 151/259 (58%), Gaps = 5/259 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D  GGAGIQADLKT  A G +G S + A+ AQN+ GV  V+ +  + V AQ+
Sbjct: 34  RVLTIAGSDSGGGAGIQADLKTMLAFGVHGMSAVVAVTAQNSLGVHGVWDLPAEAVRAQI 93

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +V  D+ +D  K GML+   +V  VA  L+R     +V+D V ++K GDPLL+P AV  
Sbjct: 94  RAVVDDIGVDAVKTGMLSSAALVALVATELERV-GAPIVVDPVGVSKHGDPLLAPDAVDV 152

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           +R  L+P  ++ TPNL E   L      R E ++     ++LA+G   VL+KGGHL  + 
Sbjct: 153 VRRELMPLATIATPNLDEVRLLTGVA-VRDETDLPRAAAAMLALGPRWVLIKGGHLPGD- 210

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D L     E    + R+  ++THGTGCTL++A+A+   R  +    V+ AK ++S AL
Sbjct: 211 AVDLLTDGSTEILLRSRRMDRRHTHGTGCTLASAIASRMARGDSPTQAVRAAKEYVSGAL 270

Query: 245 AQADTLEVGHGIGPVHHFH 263
           A    L  G GIGPV H +
Sbjct: 271 AAGFPL--GAGIGPVDHGY 287


>UniRef50_B9XCM9 Phosphomethylpyrimidine kinase n=1 Tax=bacterium Ellin514
           RepID=B9XCM9_9BACT
          Length = 264

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 98/262 (37%), Positives = 148/262 (56%), Gaps = 10/262 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIAG+D  GGAGIQADLKTF+ALG +G S IT + AQN + +  +    P  V 
Sbjct: 5   QLPIALTIAGSDSGGGAGIQADLKTFAALGVHGTSAITCITAQNPKRLLGIEACSPGIVR 64

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+++VF ++     K GML   +I+++VA   +  +   +V+D VM++ SG  LL P+A
Sbjct: 65  QQMEAVFEELPPGAAKTGMLYSEEIIKSVAGFFKSKRQTPLVVDPVMISTSGKRLLKPTA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  L+ +LLP  +L+TPNL EA  LL      + ++M    R L      A LMKGGHL 
Sbjct: 125 MRALQEKLLPLATLVTPNLDEANVLLGKAP-DSIEDMRGAARELHKRFGCAWLMKGGHLK 183

Query: 182 D-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +++ D  F  + E   T+  +   +THGTGCT SAA+ A        ++ V  AK ++
Sbjct: 184 GAKEAADVFFDGKEELLLTSRFVKGVSTHGTGCTYSAAITAYLALGLELSEAVTMAKHYI 243

Query: 241 SSALAQADTLEVGHGIGPVHHF 262
           S ++A++D +         +HF
Sbjct: 244 SESIAKSDRVA--------NHF 257


>UniRef50_B3JHT8 Putative uncharacterized protein n=2 Tax=Bacteroides
           RepID=B3JHT8_9BACE
          Length = 288

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 84/264 (31%), Positives = 137/264 (51%), Gaps = 7/264 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K      IAG++P G AG+QAD+K+ SA G Y    IT +V ++T  V+S+  I  + V 
Sbjct: 6   KLYKVFLIAGSEPLGTAGMQADIKSISACGGYAAGAITCIVDEDTIKVKSIQTIPVEMVV 65

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           +Q  S   DV  D  K GML   ++V A+ + +++ Q   +V+D VM++ +GD LL   A
Sbjct: 66  SQTYSFLEDVGADCIKTGMLYSQELVTAIGDVVKK-QSIPIVVDPVMVSSAGDKLLQDDA 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +   +  L P  ++ITPN  EA  LL      T+  M E    L   G   V++K    D
Sbjct: 125 IQAYKDCLFPYSTIITPNRREADLLLGKSL--TKDNMKEYIPELSKWGNC-VIVKSI-ED 180

Query: 182 DEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            +   D  +    +  + +   RI TKN +GTG T ++++A    R  +    V +A+++
Sbjct: 181 GDYLIDVFYNPISKCFKLYKKARIQTKNVNGTGDTFASSIATYLARGYDMNTAVDKAENF 240

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           + +A+     ++ G G GPV+ F+
Sbjct: 241 IYNAILYGSNVKFGSGYGPVYPFY 264


>UniRef50_B3DWC5 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3DWC5_METI4
          Length = 280

 Score =  255 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 84/253 (33%), Positives = 137/253 (54%), Gaps = 4/253 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    L I G+D S GAGIQ DLK  + LGAY  +VIT +VA++   V+S+Y +    + 
Sbjct: 23  KMNGILIIGGSDCSCGAGIQGDLKIITCLGAYATTVITCVVAEHPGRVESLYHLPSSIIE 82

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPS 120
           +Q  S+     ID  KIGML + ++ + + E +++++    +V+D V+ A +GD L  P 
Sbjct: 83  SQFHSILDFFPIDAIKIGMLYKKELPQKIVELIRKFKINAPIVVDPVLAAGNGDSLAEPG 142

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               L   L P  +++TPN+ EA  L       + ++ML   + L      + L+KGGHL
Sbjct: 143 MEEELARNLFPLATVVTPNIEEAELLSGLR-IESPEDMLRVAQDLSEQYSTSFLIKGGHL 201

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            D+ + D L+ +    +F  PRI+  N HGTGC+L++A A    +  +    V++AK+ L
Sbjct: 202 QDKTTIDVLYHKGIAHKFELPRILHANPHGTGCSLASATAVFLAQGLDLPKAVEKAKAKL 261

Query: 241 SSALAQADTLEVG 253
              +     L++G
Sbjct: 262 YEKIK--SQLQIG 272


>UniRef50_D1UAF8 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=D1UAF8_9DELT
          Length = 458

 Score =  253 bits (647), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 111/265 (41%), Positives = 139/265 (52%), Gaps = 5/265 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    LTIAG+D  GGAGIQADLKT + LG YG SVITAL AQNTR V  +      FVA
Sbjct: 3   RLPCILTIAGSDSGGGAGIQADLKTIAMLGGYGASVITALTAQNTRAVTGIQAPTAKFVA 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL +V  D+++D  K GML    I+ A+A  L   +   +V+D V +A SG  LL   A
Sbjct: 63  RQLQTVLDDIQVDGAKTGMLFSEPIIRAIAPILSARRF-PLVVDPVCVATSGAKLLKAEA 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V  +   + P   L+TPN PEA         R   ++    R LL MG  AVL+KGGH D
Sbjct: 122 VDAMVDLIFPLADLVTPNRPEAELFTGV-EIRDRDDVFRAARILLDMGPRAVLIKGGHAD 180

Query: 182 DEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                DW      E   F   R+ T  THGTGCTLSAA+A    +       +  A+ +L
Sbjct: 181 SLAVTDWFVAAGAEPVPFMQQRVDTACTHGTGCTLSAAIATGLGQGMEMDAAILRAQKYL 240

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           + AL  A  L  G G GP +H   W
Sbjct: 241 NLALRAAYRL--GEGGGPPNHLAPW 263


>UniRef50_Q48DP3 Phosphomethylpyrimidine kinase, putative n=29 Tax=Proteobacteria
           RepID=Q48DP3_PSE14
          Length = 304

 Score =  253 bits (647), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 81/253 (32%), Positives = 125/253 (49%), Gaps = 5/253 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
            R   L ++G DPSGGAG+QAD++   A G +    ITAL  Q+T  V     ++ ++V 
Sbjct: 45  SRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPAITALTVQDTVNVSDFRVLDREWVM 104

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ ++V +D  +   K+GML   ++V+ V + L  +    +V D V+ A  G  L     
Sbjct: 105 AQANAVLNDSNVAAVKLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEV 164

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              +R RLLP  ++ TPNLPEA  L + P         E    LL + C  +L+ GGH D
Sbjct: 165 GYAMRERLLPLSTIATPNLPEARILAELPEGT----ADECADKLL-LFCEYLLITGGHGD 219

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           ++Q  + L+ R  +        +  + HG+GCTL++ALA    +       V+ A  +  
Sbjct: 220 EQQIHNRLYVRGAQTHTFICERLPGSYHGSGCTLASALAGRIAQGEELVSAVRSALDYTW 279

Query: 242 SALAQADTLEVGH 254
             L  A+ L  G 
Sbjct: 280 RTLRDAEQLGRGQ 292


>UniRef50_D2NTJ0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Actinobacteridae RepID=D2NTJ0_9MICC
          Length = 590

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 115/282 (40%), Positives = 156/282 (55%), Gaps = 23/282 (8%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L+IAGTDPSGGAGIQADLK+ +A G YG  V T+LVAQNT GV+ V+    +F+ 
Sbjct: 45  RVPRVLSIAGTDPSGGAGIQADLKSIAASGGYGMCVTTSLVAQNTCGVREVFTPPLEFLT 104

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQL +VF DV +D  KIGML + D +  V   L  + +  VVLD VM+A SGD LL   A
Sbjct: 105 AQLAAVFDDVTVDAVKIGMLGDADTIRTVRTWLSEHPVPVVVLDPVMIASSGDRLLQAEA 164

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              LR  L+P V++ITPN+PE A L +   A+T  E  EQ  +L A     V++KGGHL 
Sbjct: 165 EQALRD-LVPLVNVITPNIPELAVLCEKEPAQTFDEAHEQAANLAAATGTTVIVKGGHLC 223

Query: 182 DEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALR----------------- 223
            + + +     +G       PR+ ++NTHGTGC+LS++LA                    
Sbjct: 224 GQDAGNTAVFPDGTCAHVRTPRLDSRNTHGTGCSLSSSLATRLGVELLQHAEVAEHTAEQ 283

Query: 224 --PRHTNWADTVQEAKSWLSSALAQADTLEV--GHGIGPVHH 261
                 +    +Q +  WL  ++A    L+V  G G GPV H
Sbjct: 284 SVLTSEDTHRALQWSTRWLHESIAAGAGLQVGSGEGHGPVDH 325


>UniRef50_B6K2F3 ThiED n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6K2F3_SCHJY
          Length = 505

 Score =  252 bits (644), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 86/280 (30%), Positives = 145/280 (51%), Gaps = 20/280 (7%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               +T+AG+D SGGAGIQADLK FSA   YG + +TA+ +QNT GV  V+ + P  V  
Sbjct: 2   LPACITVAGSDCSGGAGIQADLKVFSAHSVYGMNAVTAITSQNTVGVNGVFPVPPAVVKK 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++  +D+  +  K GML   +I++ + + +  + I++V+ D ++  K G  L+ P  V
Sbjct: 62  QIEACLTDIECNVLKTGMLFTKEILDVLIDVINNFHIKHVIADPLISTKKGMLLVKPEYV 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALL-----DAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
               ++ +P   LITPNL EA  LL     +        ++    + L+A GC +VL+K 
Sbjct: 122 KVFVTKFIPLTELITPNLSEALILLKQLTGETIGVHNASDVELIAKKLVAAGCKSVLIKC 181

Query: 178 GHL---------DDEQSPDWLF----TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRP 224
            +L          ++ S  W        +  +      +  ++ HGTGCTL++A+AA R 
Sbjct: 182 NNLWFDDDLKCTSNKDSAVWFVYVYGDAKTSKIIPKKWLAARSAHGTGCTLASAIAANRA 241

Query: 225 RHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHA 264
              +  D    A +++ +AL ++   ++GHG   + H  A
Sbjct: 242 NGLSLYDAALNAAAYVQAALEKS--FQLGHGANSLDHVFA 279


>UniRef50_C7QH05 Phosphomethylpyrimidine kinase n=15 Tax=Actinomycetales
           RepID=C7QH05_CATAD
          Length = 290

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 109/266 (40%), Positives = 150/266 (56%), Gaps = 6/266 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               LTIAG+D  GGAGIQADLKT  A G +G SV+TA+ AQN+ GVQ  + +  + V  
Sbjct: 20  PPRVLTIAGSDSGGGAGIQADLKTMLAHGVHGMSVLTAVTAQNSVGVQDFWALPIEAVER 79

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSA 121
           Q  SV  D+ +D  K GMLA  ++   VA  +        VV+D V ++K GD LL+P A
Sbjct: 80  QFRSVVDDIGVDAVKTGMLASPELTSTVARLIGTLDPSVPVVVDPVSVSKHGDALLAPEA 139

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  LR  LLP+ +++TPNL E   +        E EM+   R+L  +G   VL+KGGHL 
Sbjct: 140 LDALRGELLPRATVVTPNLDEVRLITGLDVVA-EPEMVAAARALADLGPRWVLVKGGHLS 198

Query: 182 DE-QSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           D  +S D L   +G E    APR   ++THGTGCTL++A+A+      +    V+ AK +
Sbjct: 199 DHPESVDLLVGPDGAEHWLRAPRHDNRHTHGTGCTLASAIASRLALGDDVPTAVRAAKEY 258

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAW 265
           ++  +A    L  G GIGPV H   W
Sbjct: 259 VTGGIAAGFPL--GAGIGPVDHGWRW 282


>UniRef50_Q5ZV72 Phosphomethylpyrimidine kinase ThiD/thiamin-phosphate
           pyrophosphorylase fused protein ThiE n=4 Tax=Legionella
           pneumophila RepID=Q5ZV72_LEGPH
          Length = 495

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 90/254 (35%), Positives = 135/254 (53%), Gaps = 5/254 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+    TIAG D SG AG+ AD++TFS L    CSVITA+ AQN   + +V  I  D V
Sbjct: 8   MKKPIVWTIAGVDSSGLAGVHADMETFSRLNVRACSVITAVTAQNAHSIIAVEEISRDQV 67

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AAQ  ++  +++ D  KIGML  T I E +A  L+ Y+   VVLD ++ + SG  L  P 
Sbjct: 68  AAQCRALELNLKPDAIKIGMLCSTPICEEIAYFLKGYEG-FVVLDPIITSSSGTNLFFPD 126

Query: 121 AVATLRS--RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
                 +  +L P +++ITPN  EA  +L+     + Q+++     LL++G   VL+KGG
Sbjct: 127 LQQHKNNLIQLFPYITIITPNRIEAEIILN-RSIYSYQDIINAASDLLSLGAKQVLLKGG 185

Query: 179 HLDDEQ-SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H+ D   S D+    +        R    N  GTGC LS+AL A      +  D +  AK
Sbjct: 186 HVKDNSFSQDYWTDGKESFWIANRRFPETNYRGTGCVLSSALTACLALGYSIKDAIVIAK 245

Query: 238 SWLSSALAQADTLE 251
            +++  + Q+  ++
Sbjct: 246 MYVNRGIRQSIEID 259


>UniRef50_A9A225 Phosphomethylpyrimidine kinase n=2 Tax=marine archaeal group 1
           RepID=A9A225_NITMS
          Length = 432

 Score =  250 bits (640), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 73/250 (29%), Positives = 135/250 (54%), Gaps = 4/250 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +N L+I G+DPS GAGIQ+D++ FSALG +  +VITA+ +QNT     V  +    +  Q
Sbjct: 1   MNILSIGGSDPSSGAGIQSDIRVFSALGVHTLTVITAITSQNTSKFGMVEPVSSKILQKQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L+SVFSD +I+  KIGM+  + I++ + ++L++ +   +V+D V+ + +G  L+  +A  
Sbjct: 61  LESVFSDFKINGVKIGMVYNSKIIKIIHQQLKKLK-IPIVVDPVIRSTTGGSLIENNARK 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
             +  ++P  ++ITPN  EA  L       T+    +  + +  MG   V + G   + +
Sbjct: 120 DFQKYIVPLATIITPNKKEAELLTKMK-ISTKNTPEKVAKEIQNMGAKNVTITGI-EEKK 177

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D++  +  +   +  +I  K  HG+GC  SAA+     +  +  +++  AK +   +
Sbjct: 178 KVSDFVLEKNSKYIISGEKI-PKINHGSGCIHSAAVVYSLAKKKSIKESLYFAKKFTYKS 236

Query: 244 LAQADTLEVG 253
           +  A  +  G
Sbjct: 237 IKNAKKIGKG 246


>UniRef50_A1SM66 Phosphomethylpyrimidine kinase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SM66_NOCSJ
          Length = 270

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 97/266 (36%), Positives = 144/266 (54%), Gaps = 9/266 (3%)

Query: 1   MKRINA-LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           M+     LT+AGTD  G AG+ ADL TF+ALGA+G   +TA+ AQ+T GV +V  +  D 
Sbjct: 1   MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADH 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           V AQ+D+V  D+ +   K GML   +I   VA+         +V+D V+   SG  L   
Sbjct: 61  VRAQVDAVLDDLPVAVAKAGMLGSAEIAGVVADL---PPGLPLVVDPVLRTTSGSVLADD 117

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           + VA  R  +LP+ +++TPNL EA  L     A +E+ +    R+L A+G  AV++ GG 
Sbjct: 118 ALVAAYRDHILPRCTVVTPNLAEARRLAG---AGSEEPLEHVARALQALGP-AVVLTGGD 173

Query: 180 LDDEQSPDWLF-TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            + +   D++   R        P + T N HGTGCT SAALA    R        + A++
Sbjct: 174 PESDWCRDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQA 233

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHA 264
           ++++AL ++    +G G GPV H  A
Sbjct: 234 FVAAALRRSAGWRLGRGRGPVAHTFA 259


>UniRef50_Q18GX7 Phosphomethylpyrimidine kinase n=1 Tax=Haloquadratum walsbyi DSM
           16790 RepID=Q18GX7_HALWD
          Length = 273

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 99/265 (37%), Positives = 141/265 (53%), Gaps = 10/265 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIA +D SGGAGIQADLKT +  G YG SV+ +  AQNT+GV S + + P  + 
Sbjct: 7   ELPYALTIASSDSSGGAGIQADLKTMTRFGVYGGSVVVSTTAQNTQGVDSTHVLPPAEIR 66

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+SV  D+ ID  K+GMLA  + +E V + L  Y    VV+D VM+A SGD LL+ +A
Sbjct: 67  TQLESVAEDIDIDAIKLGMLATAEAIETVDDCLMGYDG-PVVIDPVMVATSGDRLLAENA 125

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +      L    +L+TPN  E  AL       T +      +     G  AVL KGGH++
Sbjct: 126 IDVYTD-LFAHATLLTPNADETEALTGVWP-DTVEARERAAKQFFDWGVDAVLFKGGHIE 183

Query: 182 DEQ--SPDWLF--TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            ++    D L       +   T  R+ T +THG+GCTL++A+AA      +    V +  
Sbjct: 184 TDENTVQDILIGADAGTQLTITGDRVETAHTHGSGCTLASAIAAGLAHDVDIETAVSDGV 243

Query: 238 SWLSSALAQADTLEVGHGIGPVHHF 262
            ++ +AL  A T+      G V+H 
Sbjct: 244 EFVQTALQNAATIGA---NGSVNHL 265


>UniRef50_C7R6N5 Thiamine-phosphate pyrophosphorylase n=1 Tax=Kangiella koreensis
           DSM 16069 RepID=C7R6N5_KANKD
          Length = 493

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 79/260 (30%), Positives = 131/260 (50%), Gaps = 6/260 (2%)

Query: 1   MK---RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK   +    + AG D SG AG  AD++T  ALGA+ C V TAL AQN++ V ++     
Sbjct: 1   MKVTGKPVVWSYAGLDNSGMAGQVADIRTIEALGAHACCVTTALTAQNSQRVVAINPSAK 60

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQR-YQIQNVVLDTVMLAKSGDPL 116
           + + +QL+++    + +  K+G+L   + ++ +   L++      +V D V+ + SG   
Sbjct: 61  EQLQSQLEALQELGQPNAIKVGLLPSEESIQLLITYLEKASNPIQLVFDPVIESSSGTQF 120

Query: 117 LSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
           +    +  L  +LLP V++ TPN+ E A +      ++  ++  Q + LL  G  AVL+K
Sbjct: 121 MPDEVLEQL-EKLLPLVTVFTPNIDELARITGQK-IQSIDDIESQAKKLLESGTSAVLVK 178

Query: 177 GGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEA 236
           GGH   EQ+ D+   R+ +    + R  T NT GTGC LS+A+A       +  D V   
Sbjct: 179 GGHWPSEQASDFFVNRQHQFWLHSDRQETDNTRGTGCVLSSAIATALALDYSVEDAVVIG 238

Query: 237 KSWLSSALAQADTLEVGHGI 256
           K  L+  L  +  +    G 
Sbjct: 239 KMVLNQGLRHSYGIRDQKGP 258


>UniRef50_A0B7E3 Phosphomethylpyrimidine kinase n=2 Tax=Methanosarcinales
           RepID=A0B7E3_METTP
          Length = 452

 Score =  249 bits (637), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 98/253 (38%), Positives = 141/253 (55%), Gaps = 12/253 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+ALG +G SVITA+ AQNT GV+ V+ I  + +A+QLD++  D  I   K G
Sbjct: 19  IQADLKTFAALGVHGLSVITAVTAQNTLGVREVFPIPAEMIASQLDALVEDFDISWAKTG 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   D +  VAERL+  +   VV+D V+ A++G  L++  A+ TLR  L+P  S+ITPN
Sbjct: 79  MLFSPDAISLVAERLRELRCS-VVVDPVIAAEAGGSLIAEGAILTLRDELIPVASVITPN 137

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-------DEQSPDWLFTR 192
           + EA A+         +   E    +L MG  AV++ GGHLD        ++  D L T+
Sbjct: 138 IFEAEAITGVKVV-DLESAREAAMRILDMGARAVVITGGHLDCRAAGMPADECVDLLVTK 196

Query: 193 EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEV 252
           +     +  R    N HG GCT SAAL AL     +  D V++A ++ + ++  +    V
Sbjct: 197 DAVACVSGKRREGGN-HGVGCTYSAALTALLSMGMSLDDAVRQAHNFAARSIEGSR--PV 253

Query: 253 GHGIGPVHHFHAW 265
           GHG  PV    + 
Sbjct: 254 GHGAAPVDQTASL 266


>UniRef50_Q7V2V2 Phosphomethylpyrimidine kinase n=8 Tax=Prochlorococcus marinus
           RepID=Q7V2V2_PROMP
          Length = 262

 Score =  249 bits (637), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 86/246 (34%), Positives = 147/246 (59%), Gaps = 5/246 (2%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           QADL+TF AL  +GCSVIT + AQN+  V+ V  ++ D + +Q+D++FSD  I + K GM
Sbjct: 21  QADLRTFMALKVHGCSVITCVTAQNSVQVKCVEPLKKDTLTSQIDTLFSDFDIKSLKTGM 80

Query: 81  LAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNL 140
           L    I+ A A +L+ + I  ++ D VM++++G  LL  SA+   +  LLP   L+TPN+
Sbjct: 81  LLNDSIINATALKLKSFSIPKII-DPVMVSRTGSKLLEDSAINAYKKLLLPIADLVTPNI 139

Query: 141 PEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFT-REGEQRFT 199
            EA  L +    + + ++ +  +S++ +G  AVL+KGG L D +  D+      G++ F 
Sbjct: 140 FEANLLSNLD-IKNQVDIEQSAKSIIKLGAKAVLIKGGGLKDMKGRDFYLDVNGGKKWFI 198

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
              I T+NTH +GCTLSAA+   +    +  +++Q++K ++  +L  +   ++G G GP+
Sbjct: 199 NKFINTQNTHCSGCTLSAAICGYQALGFDLIESIQKSKIFIERSLKNS--YQIGSGPGPL 256

Query: 260 HHFHAW 265
            H+ + 
Sbjct: 257 GHYQSL 262


>UniRef50_B8IYN0 Phosphomethylpyrimidine kinase n=2 Tax=Desulfovibrio
           RepID=B8IYN0_DESDA
          Length = 269

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 105/261 (40%), Positives = 142/261 (54%), Gaps = 6/261 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
             N LTIAG+D  GGAGIQADLKT  ALG YG SVI AL AQN +GV  ++  +PDFVA 
Sbjct: 4   PPNILTIAGSDSGGGAGIQADLKTIMALGGYGMSVIAALTAQNGQGVTGIHAPDPDFVAL 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL +V     +   K GML    I++A+A  L++     +V+D V +++SG  LL   AV
Sbjct: 64  QLCTVLDGFPVAAAKTGMLFSAPIIKAIAPILRKRDF-PLVVDPVSISQSGSVLLQEDAV 122

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L   +LP   L+TPN PEA  L +        +    G  LL MG  AVL+KGGH++ 
Sbjct: 123 KALVQEILPGCDLLTPNRPEAEMLTNMT-IDNLDDAAAAGEKLLQMGARAVLIKGGHMES 181

Query: 183 EQSPD--WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                       +  +     ++ T N HGTGCTLSAA+A    +       V  A+ +L
Sbjct: 182 NVVVTDCLCMEGQAPKHLPQAKVETVNNHGTGCTLSAAIATGLGKGLPLQVAVTRAQEFL 241

Query: 241 SSALAQADTLEVGHGIGPVHH 261
           + AL ++     G+G GPV+H
Sbjct: 242 NLALRRS--YSPGNGCGPVNH 260


>UniRef50_C4QXJ6 Protein with similarity to hydroxymethylpyrimidine phosphate
           kinases n=1 Tax=Pichia pastoris GS115 RepID=C4QXJ6_PICPG
          Length = 557

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 92/292 (31%), Positives = 152/292 (52%), Gaps = 29/292 (9%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    LT+AG+DPSGGAGI+AD+KT SA    G S I AL AQNT GV++V + +  F+ 
Sbjct: 27  RVPTVLTLAGSDPSGGAGIEADIKTISAFHCLGLSAINALTAQNTTGVKNVLQTDERFLT 86

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPS 120
             L ++F D+RID  K GM+     V+ +   L ++ + + +V+D V+ + SG  L    
Sbjct: 87  QLLQALFEDMRIDAIKTGMMTSKA-VKLLPFYLDKFHRGKPLVIDPVLSSTSGFDLGKLD 145

Query: 121 AVATLRSRLLPQVSLITPNLPEA----AALLDAP------HARTEQEMLEQGRSLLA-MG 169
            + +  S    + ++ITPN  EA     A+                ++    + L   +G
Sbjct: 146 VLKSSISTFFAKATVITPNFIEAKKIMCAIQGISFDTFDLPVNGINDLKALAKFLQQNIG 205

Query: 170 CGAVLMKGGHLDDEQ--------------SPDWLFTREG-EQRFTAPRIMTKNTHGTGCT 214
           C +VL+KGGH+  ++                + L+ + G    F +    +K THGTGCT
Sbjct: 206 CQSVLVKGGHIPWDEDFRPSDITGKPPRYLTEVLYEQSGDVTVFKSDFNRSKFTHGTGCT 265

Query: 215 LSAALAALRPRHTNWADTVQEAKSWLSSALAQADT-LEVGHGIGPVHHFHAW 265
           L++A+AA   R  + +++VQ + S++ +++  AD  L  G G GP++H +  
Sbjct: 266 LASAMAANLARGLSISESVQLSISFVQNSIKYADKSLGSGTGYGPMNHLYNI 317


>UniRef50_Q04W62 Phosphomethylpyrimidine kinase n=6 Tax=Leptospira
           RepID=Q04W62_LEPBJ
          Length = 270

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 84/249 (33%), Positives = 129/249 (51%), Gaps = 8/249 (3%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+AL  +G S IT L +QN  G+  +  +  DF+  Q+ +V     + + K G
Sbjct: 23  IQADLKTFTALDTFGTSAITCLTSQNPSGITEILEVNADFLEKQILAVLDYFPVKSIKTG 82

Query: 80  MLAETDIVEAVAERLQRYQIQN----VVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSL 135
           ML  T I+E  +  L   +       +V+D VM++  G  LL  SA+  L ++L+P   L
Sbjct: 83  MLFSTAIIEKTSYLLSNRKNTEKNFSLVIDPVMVSTRGSKLLQESAIDILLTKLIPLADL 142

Query: 136 ITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP-DWLFTREG 194
           ITPNL EA  L     +++ + M +  +++       VL+KGGHL +E+   D LF  + 
Sbjct: 143 ITPNLDEAEILTGKKISKSRE-MPDFAKAIFEKFKVPVLLKGGHLQNEEVALDILFDGKS 201

Query: 195 EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGH 254
             +F  P +     HGTGCT S+A+ +   R    A+ +Q AK +L +A+ Q+       
Sbjct: 202 ISKFEKPFVNGFYPHGTGCTYSSAITSYLARGEKLAEAIQLAKEYLHAAIEQSYAAGKDK 261

Query: 255 --GIGPVHH 261
                PV H
Sbjct: 262 TLNHTPVLH 270


>UniRef50_Q8CTQ7 Putative pyridoxine kinase n=155 Tax=Bacteria RepID=PDXK_STAES
          Length = 276

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQN-TRGVQSVYRIEPDF 59
           M     LTIAG+D S GAG+QADLKTF  L  YG   +T++V  +       V  I+ + 
Sbjct: 1   MALKKVLTIAGSDTSAGAGMQADLKTFQELDVYGMVALTSIVTMDKETWSHDVTPIDMNV 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
              QL++  S +  D  K GML   DI++   +          V+D VM+ K  D +L+P
Sbjct: 61  FEKQLETAIS-IGPDAIKTGMLGTQDIIKRAGDVFVESGADYFVVDPVMVCKGEDEVLNP 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
                +   LLP+ +++TPNL EA  L       + ++M +  + +   G   V++KGG 
Sbjct: 120 GNTEAMIQYLLPKATVVTPNLFEAGQLSGLGKLTSIEDMKKAAQVIYDKGTPHVIIKGGK 179

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            LD ++S D  +  +   + T         HG GCT +AA  A      +  + +  AK+
Sbjct: 180 ALDQDKSYDLYYDGQQFYQLTTDMFQQSYNHGAGCTFAAATTAYLANGKSPKEAIIAAKA 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           +++SA+      ++   +GPV H
Sbjct: 240 FVASAIKNG--WKMNDFVGPVDH 260


>UniRef50_C8WAW8 Phosphomethylpyrimidine kinase n=3 Tax=Zymomonas mobilis
           RepID=C8WAW8_ZYMMN
          Length = 283

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 95/261 (36%), Positives = 147/261 (56%), Gaps = 5/261 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    LTIAG+D  GGAGIQAD+++ + LG +  + IT+L AQNT+GV ++  + P  V 
Sbjct: 12  QPARILTIAGSDSGGGAGIQADIRSITMLGGHALTAITSLTAQNTQGVSAIDVVSPQMVI 71

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+D+V +D+ +   KIGM+   ++  AVA+ L++     VVLD VM+A SG  L     
Sbjct: 72  AQIDAVVTDIGVSAIKIGMIGSGEVAVAVADYLEKIPNIPVVLDPVMVATSGSALADKKT 131

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +     RL+ +  LITPN+PE   L       ++  ++   + L       +L KGGH +
Sbjct: 132 IQAF-DRLMYRADLITPNIPELEVLT-KQDCSSDASLIAAAQQLARHYDCPILAKGGHGE 189

Query: 182 DEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            E   D L   +GE   +   RI T+NTHGTGC+LS+A+A    +     + +  A+ ++
Sbjct: 190 GEILTDRLVMPDGEVISWQDSRIPTQNTHGTGCSLSSAIATSLGQGLPLKEAITRARQYI 249

Query: 241 SSALAQADTLEVGHGIGPVHH 261
            +AL +A +L  G G GP+ H
Sbjct: 250 RTALEKAPSL--GKGHGPIGH 268


>UniRef50_B8GHH9 Phosphomethylpyrimidine kinase n=1 Tax=Methanosphaerula palustris
           E1-9c RepID=B8GHH9_METPE
          Length = 280

 Score =  246 bits (630), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 95/240 (39%), Positives = 134/240 (55%), Gaps = 3/240 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
            A TIAG+DP+GGAGIQADL TF+A+G +G SVITAL AQ    V S +      VA QL
Sbjct: 8   CACTIAGSDPTGGAGIQADLSTFAAMGVWGLSVITALTAQTPERVDSTWVQPAPIVATQL 67

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
             +  +  I   K GML +  +++ + + L       +V+D V+++ SG  LL+  A+  
Sbjct: 68  KVLLEEFHIGAFKTGMLGDGSVIDTITDLLPE--GVPLVVDPVLVSSSGHRLLAEEAIEL 125

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQ 184
           L+ RLLP+ ++ITPNLPE   L       ++ E++  G+ LL +G  AV++KGGH    +
Sbjct: 126 LKERLLPRATVITPNLPETEVLSGLSPLCSDDEVIRAGKVLLDLGAAAVIIKGGHRAGAR 185

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           + D L T       ++ R      HGTGC  SAAL AL  R        QEAK  +S A+
Sbjct: 186 ATDLLITASTVIPLSSFRR-PYPVHGTGCCFSAALTALLARGYPLPTAAQEAKCLISRAV 244


>UniRef50_A2SRR0 Phosphomethylpyrimidine kinase n=1 Tax=Methanocorpusculum labreanum
           Z RepID=A2SRR0_METLZ
          Length = 266

 Score =  246 bits (630), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 86/249 (34%), Positives = 123/249 (49%), Gaps = 3/249 (1%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
           A TIAG+DPS GAGIQ DLKT +A G +G +VI AL AQN   V     +   F+  Q+D
Sbjct: 4   AATIAGSDPSAGAGIQVDLKTMAACGVWGMTVIAALTAQNATHVLDSSSVPAAFIKKQID 63

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++  D  I   K GML   + V  VA  +     +N+V+D V+LA     LL  +    L
Sbjct: 64  ALEEDFPIGCYKTGMLKNAETVNIVAASIPE--GRNLVVDPVLLATKEYRLLDEAGQERL 121

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
            + LLP+ ++ITPN+PEAAAL         + M E     +  G  A ++KGGH      
Sbjct: 122 VAELLPRTTVITPNIPEAAALSGIT-ITGSESMEEAAYWFIDHGAKAAVIKGGHAHFRLG 180

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
            D    ++G            + HG+GC  ++A+AA         D V EAK +++ A+ 
Sbjct: 181 TDVFADKDGIMLVEGEVAPFTDVHGSGCCYASAIAAHIALGYPVRDAVLEAKKFVTGAIK 240

Query: 246 QADTLEVGH 254
            +     G 
Sbjct: 241 YSWEYAPGR 249


>UniRef50_C8WXY2 Phosphomethylpyrimidine kinase n=3 Tax=Bacteria RepID=C8WXY2_ALIAD
          Length = 297

 Score =  246 bits (630), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 100/244 (40%), Positives = 135/244 (55%), Gaps = 4/244 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT      YG SV+TA+ AQNT GVQ+VY +  D V AQ +SV  D+  D  K G
Sbjct: 26  IQADLKTAHQFDVYGMSVLTAVTAQNTVGVQAVYPLPVDIVRAQFESVRDDLGFDAIKTG 85

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML +   + AVA+ L       +V+D VM+AK G+ LL P  VA +  R+LP   + TPN
Sbjct: 86  MLGDRAAIHAVADALAGVDC-PIVVDPVMIAKGGEALLHPDDVAAVIERMLPLAFVATPN 144

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQSPDWLFTREGEQR 197
            PEA  L   P  R+  +      +L  +G    ++KGGHL+     + D +F       
Sbjct: 145 TPEAERLTGIP-IRSLADAARAAEALAGLGAQYAVVKGGHLEGAGHLAIDVVFHDGAWTF 203

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F APR+ +  THGTGCT S+A+AA   R     + +  AKS++S A+A A   +VG G G
Sbjct: 204 FAAPRVPSHKTHGTGCTFSSAIAACLARGARPLEAIAAAKSFISRAIAAAADWDVGRGHG 263

Query: 258 PVHH 261
           P  H
Sbjct: 264 PTDH 267


>UniRef50_Q7R735 Phosphomethylpyrimidine kinase n=2 Tax=cellular organisms
           RepID=Q7R735_PLAYO
          Length = 391

 Score =  246 bits (629), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 83/254 (32%), Positives = 125/254 (49%), Gaps = 8/254 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L+++G DP+GGAGIQAD++   A+G   C+VITAL  Q+T  V +V    PD   
Sbjct: 131 QPAIVLSLSGHDPTGGAGIQADIEAVGAIGCRACTVITALTIQDTSNVHAVQPQSPDAFL 190

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPS 120
           AQ  ++  D+ +   KIG+L    I   VA  L        VVLD V+ A  G  L S  
Sbjct: 191 AQGRALIRDLPVAAVKIGLLGSAGIAHCVATLLDELGGGVPVVLDPVLAAGGGTDLASEE 250

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  +R+ LLP+  L+TPN+PEA+ L             E    L  +GC  VL+ G H 
Sbjct: 251 LIEAVRTELLPRAVLVTPNVPEASRLGGGATE------AENAERLRLLGCPNVLITGTHA 304

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +   + L++  G++ +  PR+   + HG+GCTL+A +A            V+ A+ + 
Sbjct: 305 PTDDVVNRLYSSTGKRDYRWPRL-PYSYHGSGCTLAAXVAGYLALGHAMDAAVEWAQRFT 363

Query: 241 SSALAQADTLEVGH 254
             +L    T   G 
Sbjct: 364 WQSLRAGWTPGDGQ 377


>UniRef50_C5DKQ9 KLTH0F06732p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DKQ9_LACTC
          Length = 570

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 86/278 (30%), Positives = 137/278 (49%), Gaps = 15/278 (5%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    +T+A +DPSGGAGI+ADLKTF+A   YG + + AL AQ   GV +++ I  +   
Sbjct: 29  RLPTVMTVATSDPSGGAGIEADLKTFTAHRCYGLTGMAALTAQTPEGVYAIHEIPKEHFK 88

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI---QNVVLDTVMLAKSGDPLLS 118
             LDS   D+R+D  K GML +   VE + E           ++V+D V++A SG  L+S
Sbjct: 89  LTLDSCLRDMRVDAIKTGMLTKPA-VEVLYETFSAMPADARPHLVVDPVLVATSGSTLVS 147

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAP--HARTEQEMLEQGRSLLAMG-CGAVLM 175
             +V      L P  +L+TPN  EA  +L        + +++++    L     C  VL+
Sbjct: 148 DQSVIDFIKTLSPLATLLTPNAYEAGRILGRESLELNSVEDLIDVACELQKTTLCPNVLL 207

Query: 176 KGGHLDD------EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNW 229
           KGGH         ++  D L        + +    ++NTHGTGCTL++A+A+        
Sbjct: 208 KGGHAPWVDSNGQKRVTDVLRLGNKTVLYRSVFCTSENTHGTGCTLASAIASNLAHGEAL 267

Query: 230 ADTVQEAKSWLSSALAQADTLEVGH--GIGPVHHFHAW 265
              V     ++ +A+    T+   H    GP++H +A 
Sbjct: 268 QHAVFGGIQYVHNAIEIGCTVTQPHVKKNGPINHVYAI 305


>UniRef50_A4XG68 Phosphomethylpyrimidine kinase n=2 Tax=Clostridia
           RepID=A4XG68_CALS8
          Length = 259

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 88/256 (34%), Positives = 132/256 (51%), Gaps = 4/256 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M++   L IAG DPS GAGI  D K   +LG +  SVIT L  Q T  V     I+PDF 
Sbjct: 1   MRK--VLVIAGFDPSCGAGIVLDTKVVRSLGEFAASVITCLTVQTTERVYDALPIDPDFF 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL  +  D+  D+ KIG+L   +I   V   ++RY ++N+V D V+ + SG       
Sbjct: 59  EYQLQKIIEDIEPDSVKIGLLGSEEITRVVLRNIRRYNLKNIVCDPVLKSTSGFEFGKDK 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQG-RSLLAMGCGAVLMKGGH 179
            V  L+S  L   S+ITPN  EA  + D      E+++L    + +  MG  + ++KGGH
Sbjct: 119 FVEFLKSEFLKACSVITPNKTEAEVIFDMKIENFEEDILNSIQQKMNKMGIKSCVLKGGH 178

Query: 180 LDDEQSPDWLFTREGEQRFTAPRI-MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           +D   + D L T+    R +A +   T N HGTGC  S+A A    +  N  DT+++ K 
Sbjct: 179 VDGHLAEDVLITQTKIYRVSAKKKGSTDNIHGTGCAFSSAFATFLAKGYNMYDTLKQTKD 238

Query: 239 WLSSALAQADTLEVGH 254
           ++S+ +  +  +  G 
Sbjct: 239 FVSNLIYNSIKIGKGR 254


>UniRef50_Q9ZBR6 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=59
           Tax=Bacteria RepID=THID_STRCO
          Length = 269

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 99/246 (40%), Positives = 141/246 (57%), Gaps = 5/246 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKT  ALG +G SV+TA+ AQN+RGVQ  + +  + V AQ  SV  D+ +   K G
Sbjct: 27  IQADLKTMLALGTHGMSVLTAVTAQNSRGVQGAWELPVEAVRAQYRSVVDDIGVQAVKTG 86

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML+  ++VE VAE L        V+D V ++K GD LL+ SA+ ++R+RLLP  ++ TPN
Sbjct: 87  MLSSAELVETVAELLAGTD-APAVVDPVGVSKHGDALLASSALESVRTRLLPVATVATPN 145

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
           L E A L        E ++     ++LA G    L+KGGHL  + + D L     E    
Sbjct: 146 LDEVAQLTGVR-VDDETDLRRAAAAVLAFGPRWALIKGGHLAGD-AVDLLTDGSEEHWLR 203

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           APR+  ++THGTGCTL++A+A    +  +    V+ AK +++ A+     L  G GIGPV
Sbjct: 204 APRLDNRHTHGTGCTLASAVACGLAKGQSVPVAVRAAKEYVTGAITAGFPL--GGGIGPV 261

Query: 260 HHFHAW 265
            H  A 
Sbjct: 262 DHGWAL 267


>UniRef50_Q2W2C4 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Alphaproteobacteria RepID=Q2W2C4_MAGSA
          Length = 270

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 115/265 (43%), Positives = 158/265 (59%), Gaps = 5/265 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L +AG+D  GGAGIQAD+K  + LG +  + +TAL AQNT GV  ++ + PDFV A
Sbjct: 4   RGRVLIVAGSDSGGGAGIQADIKAVTCLGGFAATAVTALTAQNTLGVSGIHEVPPDFVRA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPSA 121
           Q+ +V SD+  D  K GMLA   IVE VA  L+       +VLD VM+AK G  LL+ SA
Sbjct: 64  QMAAVLSDIGADCIKTGMLASAAIVETVALALEELAPAVPLVLDPVMVAKGGAALLADSA 123

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              L  RL+P+  L+TPN+PEA  LL     +    M    R LLA+G  AVL+KGGHL+
Sbjct: 124 AGALVKRLVPRARLLTPNIPEAEVLLGRA-IKGADGMEGAARDLLALGPKAVLLKGGHLE 182

Query: 182 DEQSPDWLFT-REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            +   D L     G +RFT  RI +++THGTGCTL++A+AA   +     + V+ A+++L
Sbjct: 183 GDHLVDVLAEAGGGLRRFTGRRIASRSTHGTGCTLASAIAAGLAQGLGLVEAVERARAYL 242

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
             A+  A    +G G GP++H H  
Sbjct: 243 VRAIETAP--GLGSGHGPLNHGHTV 265


>UniRef50_A4YD59 Phosphomethylpyrimidine kinase n=10 Tax=Sulfolobaceae
           RepID=A4YD59_METS5
          Length = 403

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 104/265 (39%), Positives = 146/265 (55%), Gaps = 7/265 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+R  A+TIAG+D  GGAG+QADLKTF++LG +G SVIT L AQNT  V  V  + P+FV
Sbjct: 2   MQRPIAMTIAGSDSGGGAGVQADLKTFTSLGVFGVSVITGLTAQNTARVTKVLEVPPEFV 61

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q D++  D ++   K GMLA + IV+AV  +L +Y   N+VLD VM++KSG PL++  
Sbjct: 62  ESQFDTIMEDFQVKYAKTGMLASSRIVDAVERKLTQY-GINLVLDPVMISKSGYPLVTEE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            V  +  RL  +  +ITPN  EA  L      RT  ++      L       V++KGG  
Sbjct: 121 VVRDIV-RLARKSLIITPNKYEAERLTGFR-IRTRDDLRNTALHLYKSLGVNVVVKGGKA 178

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D+      E       I T N HG+G   SA++ A   +  N  D ++EAK  +
Sbjct: 179 IGGY--DFAVVDGDEIELRGELINTDNLHGSGDVFSASITAFLSKGLNLRDALREAKKVV 236

Query: 241 SSALAQADTLEVGHGIGPVHHFHAW 265
           S A+    +L +GHG GPV  F + 
Sbjct: 237 SEAIK--FSLAIGHGNGPVDPFSSV 259


>UniRef50_A9NB66 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=6 Tax=Coxiella burnetii
           RepID=A9NB66_COXBR
          Length = 479

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 76/250 (30%), Positives = 123/250 (49%), Gaps = 2/250 (0%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           ++    +I G+D SGGAG QAD+ T      +  S+IT + AQN   V  +   + D + 
Sbjct: 3   QKSIVWSIGGSDCSGGAGCQADILTCRDFNVHAASIITTITAQNAEQVLKINYCDSDLIQ 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+ ++   +     K+G+L   +IV AVA  L+ Y  + VV D V+ + SG  L +   
Sbjct: 63  KQIQALKETLPPTVIKLGLLGTKEIVTAVASYLKNYSGK-VVCDPVLNSTSGVLLHASDY 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  L+  L P V L+TPN+PEA  L+      T  +++     LL  G  AVL+KGGHL 
Sbjct: 122 LDLLKKLLFPHVDLLTPNIPEAEILIQNK-IHTFSDIISAAHQLLKCGVSAVLLKGGHLI 180

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             ++ D+    + E      +I      GTGC LS+A+++      +  D +  AK ++ 
Sbjct: 181 GSKACDFFTDGKCEFWLAHTKIPKTRVRGTGCALSSAISSAIALGYSLKDAIVVAKMYVQ 240

Query: 242 SALAQADTLE 251
             + Q   + 
Sbjct: 241 QGIRQNFKVN 250


>UniRef50_Q06490 Thiamine biosynthesis protein THI22 n=21 Tax=Saccharomycetaceae
           RepID=THI22_YEAST
          Length = 572

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 77/276 (27%), Positives = 135/276 (48%), Gaps = 13/276 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    ++IAG+D SGGAG++AD+KT +A   Y  + +T L AQ    V   + I    V+
Sbjct: 44  KLPTVMSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAHNIPKKMVS 103

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY--QIQNVVLDTVMLAKSGDPLLSP 119
             LD+   D++ +  K GML   D +E + E+L +       +V+D V+ A S       
Sbjct: 104 QILDANLQDMKCNVIKTGML-TVDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPTGK 162

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDA-PHARTEQEMLEQGRSLLA-MGCGAVLMKG 177
             V+ +  ++ P   ++TPN+ +   LL         Q++LE  + L     C  +L+KG
Sbjct: 163 DVVSLIIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNILVKG 222

Query: 178 GHLD-----DEQSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWA 230
           GH+      ++   D L+    +    F    + T  THG GCTL++A+A+   R  + +
Sbjct: 223 GHIPCDDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLARGYSLS 282

Query: 231 DTVQEAKSWLSSALAQADTL-EVGHGIGPVHHFHAW 265
            +V     ++ +A+A    + +    +GP++H +A 
Sbjct: 283 QSVYGGIEYVQNAIAIGCDVTKKAVKVGPINHVYAV 318


>UniRef50_A5DVD5 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus
           RepID=A5DVD5_LODEL
          Length = 585

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 97/298 (32%), Positives = 140/298 (46%), Gaps = 45/298 (15%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LTIAG+D SGGAGI+ADLKTFSA   YG + ITAL AQNT GV++      + V 
Sbjct: 17  KLPVVLTIAGSDSSGGAGIEADLKTFSAFDVYGMTCITALTAQNTTGVKTYKETSRELVH 76

Query: 62  AQLDSVFSDVR-------IDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSG 113
             L +   D+        +   K GML ++ I     E L ++     +V+D VM+  SG
Sbjct: 77  EILKANLEDMYENEEKGPLKVIKTGMLTKSAI-----EELAQFDLKIKMVIDPVMVTTSG 131

Query: 114 DPLLSPSAVATLRSRLLPQVSLITPNLPEAA----ALLDAPHARTEQEMLEQGRSLLAM- 168
             LL    V      L+    L+TPN  EA      L  +   +   E ++    L  M 
Sbjct: 132 SKLLDHEGVKLCVDNLMKNAFLVTPNFVEAETIYKILGKSAQVKQLDEFIKFTVDLQKMV 191

Query: 169 GCGAVLMKGGHLDDE-----------------------QSPDWLFTREG--EQRFTAPRI 203
           GC  +L+KGGH+  +                       +  D L+  E      F +  I
Sbjct: 192 GCKNILVKGGHIPFDANGKVVEDTTAEGQAQPQSNPGLKVIDVLYESENDVVTIFESKYI 251

Query: 204 MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
            + N+HGTGCTL++A+AA   + T+ AD+V     ++   + +   L  GHG GP++H
Sbjct: 252 ESDNSHGTGCTLASAIAANIAKGTSLADSVAIGIDYIHQGMLKMSKL--GHGKGPLNH 307


>UniRef50_Q9ZBL1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=15
           Tax=Actinomycetales RepID=THID_MYCLE
          Length = 279

 Score =  243 bits (621), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 100/265 (37%), Positives = 145/265 (54%), Gaps = 9/265 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             L+IAG+D  GGAGIQAD++T + LG + C+ +TA+  QNT GV+  + I  + VA+Q+
Sbjct: 15  RVLSIAGSDSGGGAGIQADMRTMTVLGVHACTAVTAVTIQNTLGVEGFHEIPAEIVASQI 74

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAE-RLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
            +V +D+ I + K GMLA + I+ AVAE  L+      +V+D V  +  GDPLL+  A+ 
Sbjct: 75  KAVVTDIGIQSAKTGMLASSSIIAAVAETWLRLELTTPLVVDPVCASMHGDPLLTGEAMD 134

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DD 182
           +LR RL P  +++TPNL E   L+      TE +      +L A+G    L+KGGHL   
Sbjct: 135 SLRDRLFPLATVVTPNLDEVRLLVGIDVVDTESQ-RAAAMALHALGPQWALVKGGHLRSS 193

Query: 183 EQSPDWLFTREG----EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           ++S D L+           F APR+ T N HG G TL+AA++          D V   K 
Sbjct: 194 DRSCDLLYGGSSAGVAFHEFDAPRVQTGNDHGGGDTLAAAVSCALAHGYTVPDAVGFGKR 253

Query: 239 WLSSALAQADTLEVGHGIGPVHHFH 263
           W++  L  A    +G G GPV    
Sbjct: 254 WVTECLRDA--YPLGRGHGPVSPLF 276


>UniRef50_C8X581 Phosphomethylpyrimidine kinase n=5 Tax=Bacteria RepID=C8X581_DESRD
          Length = 269

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 116/268 (43%), Positives = 156/268 (58%), Gaps = 10/268 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   LTIAG+D  GGAGIQ DLKT + LG +G SV+TAL AQNT GVQ V+ +   F+
Sbjct: 1   MKK--ILTIAGSDSGGGAGIQTDLKTIALLGGHGTSVLTALTAQNTLGVQGVHPVPEAFI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++SV +D+  DT KIGMLA   IV  VAE L+      +VLD VM+A SGDPLL+  
Sbjct: 59  RQQMESVLTDIGTDTLKIGMLATAGIVRTVAEGLRALTAAPLVLDPVMVATSGDPLLAED 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTE--QEMLEQGRSLLAMGCGAVLMKGG 178
           A  +L+  L P  +++TPNL EA  L   P       ++       + A G   VL+KGG
Sbjct: 119 ARQSLQDNLFPLAAVVTPNLGEAELLCGFPVTDRAGMEQAAAA---IHARGPAYVLLKGG 175

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           HL D+ + D LF           R+ T +THGTGCT SAA+A    +  +    V +AK 
Sbjct: 176 HLVDD-AADLLFDGHQGIWLPGHRVDTVHTHGTGCTYSAAIATFLAQSGDMVQAVTQAKR 234

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAWW 266
           +++ A+A A  L  GHG GP + + A +
Sbjct: 235 FITRAIAAAGPL--GHGRGPTNPYAAVF 260


>UniRef50_Q12U29 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase n=3
           Tax=Methanosarcinaceae RepID=Q12U29_METBU
          Length = 456

 Score =  242 bits (619), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 96/264 (36%), Positives = 149/264 (56%), Gaps = 10/264 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D  GGAGI+AD+KT ++L  +G   IT++ +QNT GVQS Y + P  V+ Q
Sbjct: 15  PVVLTIAGSDSGGGAGIEADIKTLASLYVHGACAITSVTSQNTTGVQSAYELPPTVVSDQ 74

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V +D+ +   K GML+  +IV AVA+R+++Y    VV+D VM A++G  LL   AV+
Sbjct: 75  MDAVCTDMDVRWAKTGMLSSANIVRAVADRVKKY-GLKVVVDPVMAAEAGGDLLEKDAVS 133

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L+  LLP    +TPN+ EA  L       T ++ +E  +++ ++G  AV++ GGH D  
Sbjct: 134 ILKDELLPISYAVTPNISEAEILSGM-SITTREDAMEAAKAIASLGLNAVIITGGHSDG- 191

Query: 184 QSPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
              D ++    +     +   I    THG+GCT SAAL +   R  +  D    AK ++ 
Sbjct: 192 --VDLVYDSVTDEFTEVSGKLIEGG-THGSGCTYSAALTSYLARGYSLQDAAIGAKEFVE 248

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
           S +  +    +G G+GPV+     
Sbjct: 249 SGILLSK--NIGKGVGPVNQMGYL 270


>UniRef50_C1F301 Phosphomethylpyrimidine kinase n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F301_ACIC5
          Length = 303

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 104/265 (39%), Positives = 134/265 (50%), Gaps = 8/265 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG DPS GAGI ADLK F+A   YG S +TAL  Q+T+GV     ++   +   L
Sbjct: 36  VVLTIAGFDPSSGAGITADLKVFAACQLYGVSAVTALTVQSTQGVLRSQPVDSALLGETL 95

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQR--YQIQNVVLDTVMLAKSGDPLLSPSAV 122
             +  D+ I   KIGML   + V  VA  L+   +  + VVLD V+ + SG  LL  S  
Sbjct: 96  RCLQQDLPIAGVKIGMLGSGENVATVAAWLRDFSFPRERVVLDPVLRSSSGRDLLDASGQ 155

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             LR +LLPQ   ITPNL E AAL   P     ++M     +L A     V   GGHLD 
Sbjct: 156 TLLREQLLPQTGWITPNLDELAALTGLP-VTNREQMRAAAEALAATAGLRVAATGGHLDP 214

Query: 183 EQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
               D L T EGE Q F    + T+ THGTGC  S+AL        +    V  AK ++ 
Sbjct: 215 PD--DLLATPEGEAQWFPGRHLATRATHGTGCAFSSALLCRLVLGDSAEAAVAAAKQYVK 272

Query: 242 SALAQADTLEVGHGIGPVHHFHAWW 266
            A+  A    +G G GP+HH +  +
Sbjct: 273 EAMEAA--YPIGRGRGPMHHLYRAF 295


>UniRef50_A4S5F9 Predicted protein n=3 Tax=Ostreococcus RepID=A4S5F9_OSTLU
          Length = 478

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 113/271 (41%), Positives = 165/271 (60%), Gaps = 9/271 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   L +AG+D  GGAG+QAD+K   A GA+  + ITAL AQNT GV  V+    +F+
Sbjct: 1   MVRGKVLVVAGSDSGGGAGVQADVKAILAHGAFATTAITALTAQNTTGVHGVHAAPLEFI 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ+++V +D+  D  K GMLA      AVA+ ++R+++ NVV+DTVMLAK G  LL   
Sbjct: 61  EAQIEAVVTDLPPDACKTGMLANAATTRAVADAIERHRLTNVVVDTVMLAKGGASLLEAE 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHAR-TEQEMLEQGRSLLAMGCGAVLMKGGH 179
           A+  +R RL P  ++ITPN+PEAAALL+        + M  + + L  +GC  VL+KGGH
Sbjct: 121 ALEVMRDRLAPLATVITPNVPEAAALLNLSEEEFVMETMATRAKELGKLGCQWVLLKGGH 180

Query: 180 LDDE--QSPDWLFTREG--EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           + D+   S D+L+         F++ RI T++THGTGCTL++++AA   +  +    V  
Sbjct: 181 VKDDAEMSVDYLYEANTGRTTTFSSARIDTRHTHGTGCTLASSIAASLAQRYDVPTAVHR 240

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHH--FHA 264
           AK ++S A+  +     G G GP++H  FHA
Sbjct: 241 AKRYISEAIRTSPGY--GAGHGPLNHLPFHA 269


>UniRef50_C5LCI6 Phosphomethylpyrimidine kinase, putative n=2 Tax=Perkinsus marinus
           ATCC 50983 RepID=C5LCI6_9ALVE
          Length = 504

 Score =  241 bits (617), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 96/276 (34%), Positives = 147/276 (53%), Gaps = 13/276 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L ++G+D  GGAG QADLKT  ALG Y  S +T++ AQNT+GVQ +  +  D  
Sbjct: 228 MKIPTVLIVSGSDSGGGAGHQADLKTLEALGVYSTSALTSITAQNTKGVQQIQVVNEDIF 287

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLL--- 117
           AAQ++SV SD  +   K+G++     +E V E+L       +V+D V++A SGD L+   
Sbjct: 288 AAQMNSVTSDFEVSVVKLGLVPTARQLEIVGEKLAEL---PMVVDPVLVATSGDDLVAQK 344

Query: 118 -SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
            +   +A  + R+ P+ ++ITPN+ EA  +L         E     ++L   G   VL+K
Sbjct: 345 NAEDVLAMYKERIFPRATIITPNVVEAERILGRKEISGVYEARAAAQALAQYGSKYVLLK 404

Query: 177 GGHLDDEQ--SPDWLFT--REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           GGH + +     D L+   ++    FT  RI T NTHGTGCTL++A++A   R       
Sbjct: 405 GGHDETDPKACRDVLYDREKDEFYEFTNRRIATINTHGTGCTLASAISAFMARGYPVPVA 464

Query: 233 VQEAKSWLSSALAQADTLEVGHG-IGPVHHFHA-WW 266
           V+ A  +L   + ++  + +G G   P+ H     W
Sbjct: 465 VERAIGYLHEVIVRSCGVPLGQGTNRPLVHSANSVW 500


>UniRef50_B2A1A9 Phosphomethylpyrimidine kinase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A1A9_NATTJ
          Length = 275

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 95/256 (37%), Positives = 146/256 (57%), Gaps = 3/256 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    +TIAG+D  GGAGIQADLKTF ++G +G +V+T + AQNT GVQ+   +E   VA
Sbjct: 3   KTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVA 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQN-VVLDTVMLAKSGDPLLSPS 120
            Q  SV  D+ I   K GML+   I+E V++ L  +  +  +V+D V+ A SGD LL   
Sbjct: 63  EQFKSVAEDMEISAVKTGMLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQ 122

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV+TL  +L+P   +ITPN+PEA  L       + +++ +    L   G  +VL+KGGH 
Sbjct: 123 AVSTLLEKLIPISDIITPNIPEAEILTGINIDHS-KDLQKAAHKLKEAGAKSVLIKGGHT 181

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
               + D  F  +    F+A R+   + HGTGCTL +A+ A   +  +   +++ AK ++
Sbjct: 182 SGN-ATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYV 240

Query: 241 SSALAQADTLEVGHGI 256
           + A+  + T+  G  +
Sbjct: 241 TQAINNSFTIGEGSKV 256


>UniRef50_Q3IFN5 Putative phosphomethylpyrimidine kinase/thiamin-phosphate
           pyrophosphorylase n=3 Tax=Alteromonadales
           RepID=Q3IFN5_PSEHT
          Length = 508

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 90/266 (33%), Positives = 136/266 (51%), Gaps = 14/266 (5%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
              TIAG+D  GGAGIQAD+K   + G +GC+ ITAL AQN+ GV+++  +  D + +QL
Sbjct: 4   VVWTIAGSDSGGGAGIQADIKAMQSFGVHGCTAITALTAQNSLGVEAINAVSTDIIESQL 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-----IQNVVLDTVMLAKSGDPLLSP 119
            ++  D++    KIGMLA    ++ ++E +  Y+        +V D V +A SGD L   
Sbjct: 64  LALEKDMKAKVIKIGMLANVQQIQLISEHISHYKAKWPVPPVIVYDPVAIASSGDLLTEE 123

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             V+ ++  LLP V +ITPN  E   L           + E    LL+ G  AV++KGGH
Sbjct: 124 DTVSAIKECLLPLVDVITPNTHETQLLTGVYLIG-PAAIKEAANKLLSWGAKAVVIKGGH 182

Query: 180 LD--DEQSPDWLFT----REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
            D       D+       +  E      +I T + HGTGC++++ +AA   +     D  
Sbjct: 183 WDYPSGYCIDYCINNFTQKGEEYWLGNEKIQTPHNHGTGCSMASVIAACLAKDYPLKDAF 242

Query: 234 QEAKSWLSSALAQADTLEVGHGIGPV 259
             AK++++  L  A     G GIGPV
Sbjct: 243 ILAKAYINQGLKVAVRY--GEGIGPV 266


>UniRef50_Q6CV88 KLLA0B13926p n=1 Tax=Kluyveromyces lactis RepID=Q6CV88_KLULA
          Length = 539

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 90/269 (33%), Positives = 145/269 (53%), Gaps = 8/269 (2%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LT+AG+D SGGAG++AD+KT SA G Y  + ITAL  Q    V S    +   + 
Sbjct: 54  KLPGVLTVAGSDSSGGAGVEADVKTISAQGCYAMTCITALTCQTPGKVYSFINTDEQHIK 113

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
             L      +R D  KIGML     ++AV  +L + +   +VLD VM+A SG PL S   
Sbjct: 114 EILGHNLRSMRCDAIKIGML-NLGALKAVVSQLDQIK-VPIVLDPVMVATSGSPLSSGDV 171

Query: 122 VATL-RSRLLPQVSLITPNLPEAAALL--DAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             +     L+ +V+LITPN+PEA AL+  ++   +T  +M+   + + A     VL+KGG
Sbjct: 172 WESSEIKLLMDKVALITPNIPEAKALIRDESYDLKTVSDMVALSKRVAADCRCNVLLKGG 231

Query: 179 HLD-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           H   + +  D LF       + + R+ + N HGTGCTLS+ +A+    + +  + V ++ 
Sbjct: 232 HCPIEGKVIDVLFVDGQVYIYNSDRLNSVNLHGTGCTLSSCIASKLAYNVSLPEAVYQSI 291

Query: 238 SWLSSALAQADTLEVGHG--IGPVHHFHA 264
            ++ SA+   + ++V +    GP++H ++
Sbjct: 292 QYVHSAIICGENIKVTNCTENGPLNHIYS 320


>UniRef50_Q3BUP8 Phosphomethylpyrimidine kinase n=20 Tax=Xanthomonadaceae
           RepID=Q3BUP8_XANC5
          Length = 295

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 97/251 (38%), Positives = 140/251 (55%), Gaps = 14/251 (5%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQADLKTF+A   +G S ITAL AQ+TR V +V+     F+ AQ+D+ F+D  I   K+G
Sbjct: 49  IQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLSFLQAQVDACFADFEIQAVKLG 108

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           MLA  D++  VA+ L+RY+   VVLD VM++ SG  LL  +A+  LR+RLLP  +L+TPN
Sbjct: 109 MLANADVIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLVTPN 168

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL-DDEQSPDWLFTREGEQRF 198
            PEA  L       +         +LL +G  AVL+KGGHL +  +  D       +  F
Sbjct: 169 TPEAELLTGRR-IDSADAAEHATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVF 227

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG- 257
             PR+   + HGTGC+LSAA+AA   +  +  +  + A  +++ A+       +G   G 
Sbjct: 228 MHPRLQ-VDAHGTGCSLSAAIAAQLCQGLSLLNACEAAIDYVARAIR------IGQRPGH 280

Query: 258 ----PVHHFHA 264
                + HF A
Sbjct: 281 SDVLVLDHFGA 291


>UniRef50_A3LN87 Phosphomethylpyrimidine kinase THI21 (HMP-phosphate kinase) (HMP-P
           kinase) n=7 Tax=Saccharomycetales RepID=A3LN87_PICST
          Length = 583

 Score =  239 bits (611), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 84/302 (27%), Positives = 137/302 (45%), Gaps = 45/302 (14%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               LTIAG+D SGGAGI+ADLKTFSA   YG + I AL AQNT+ V++  +   + V  
Sbjct: 20  LPAVLTIAGSDNSGGAGIEADLKTFSAHKVYGLTCIAALTAQNTQLVKTFEKTPKELVKN 79

Query: 63  QLDSVFSDV---------RIDTTKIGMLAETDIVEAVAERLQRYQ--IQNVVLDTVMLAK 111
            L   F D           +   K GML   + V  + + L   +     +++D VM++ 
Sbjct: 80  ILQLNFDDFLYGYEDSTQPLKVIKTGML-TEEAVHVIQDFLPDIKKHNVKLIVDPVMIST 138

Query: 112 SGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAP----------HARTEQEMLEQ 161
           SG  L     +    + L+    LITPN  EA AL +               +  + ++ 
Sbjct: 139 SGSSLFDSEGMKLCVNTLISGAYLITPNFVEARALWEIACGESAAIEKLTINSLDDFIDF 198

Query: 162 GRSLLA-MGCGAVLMKGGHLDDEQ-------------------SPDWLFTR--EGEQRFT 199
            + L   +    VL+KGGH+  +                      D L+    +    F 
Sbjct: 199 VKQLQKTLKSQNVLVKGGHIPWDSRTGKPFVGTNLADVEDSIVVLDVLYESEIDKATVFE 258

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           +  I TK++HGTGCTL++A++A   +  N  +++  +  ++   +      ++G+G GP+
Sbjct: 259 SKYINTKDSHGTGCTLASAISANVAKGKNLKESISLSIDYIHKGMLSVGK-KLGYGNGPL 317

Query: 260 HH 261
           +H
Sbjct: 318 NH 319


>UniRef50_B5JTI6 Bifunctional thiED protein n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JTI6_9GAMM
          Length = 288

 Score =  239 bits (611), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 80/252 (31%), Positives = 122/252 (48%), Gaps = 6/252 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L ++G DPSGGAGI AD++  S+ G   C  ITA+  QN+R V SV+ ++P+ +  Q
Sbjct: 5   PVVLCLSGFDPSGGAGIGADIEALSSQGCQACGAITAMTVQNSRDVISVHPVDPNVIIQQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLA-KSGDPLLSPSAV 122
             +V  D+ +   KIG++   ++  A+   L  Y    VVLD V+ +  SG  L     V
Sbjct: 65  ARAVLEDMPVAVIKIGLVGSVEVAAAIHSVLSDYPDIPVVLDPVLASGGSGRALADDGLV 124

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             + + L+PQ +LITPNL EA  L                  L+  G  +VL+ GG    
Sbjct: 125 EAILNLLVPQATLITPNLREAHTL-----IAGADTRQAAAIGLMEAGAQSVLLTGGDEPG 179

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +   + LF  +   R      +    HG+GCTL+A+ A L        + V+ A+ +  +
Sbjct: 180 DDVLNTLFAEQRWVRDYHWPRLPHQYHGSGCTLAASAAGLIAHGILLEEAVEGAQEYTWN 239

Query: 243 ALAQADTLEVGH 254
           AL  A  L +G 
Sbjct: 240 ALYNAVRLGMGQ 251


>UniRef50_C4Y2K1 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4Y2K1_CLAL4
          Length = 586

 Score =  239 bits (611), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 86/293 (29%), Positives = 135/293 (46%), Gaps = 35/293 (11%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    LTIAG+D SGGAGI+AD+KT +A   YG + IT+L AQNT GV +V     + V 
Sbjct: 36  ELPAVLTIAGSDSSGGAGIEADIKTMTAHSVYGLTCITSLTAQNTLGVSAVVDTPKEHVK 95

Query: 62  AQLDSVFSDV--------RIDTTKIGMLAETDIVEAVAERLQ--RYQIQNVVLDTVMLAK 111
           A L+  F D          +   K GML   D VE +A  L     +   +V+D VM++ 
Sbjct: 96  AILEKNFEDFLEGYEGAPPLKVVKTGML-TKDAVEVLASYLDYLESKKVKLVVDPVMVST 154

Query: 112 SGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDA-----PHARTEQEMLEQGRSLL 166
           SG  L +   +   +  ++P+  L  PN  EA  L            T  +       L 
Sbjct: 155 SGKILTNDETMQLCQKTIIPRAYLCMPNYVEALHLWKCFGDEPIEIETVDQFKTFTVRLQ 214

Query: 167 A-MGCGAVLMKGGHLDD---------------EQSPDWLF--TREGEQRFTAPRIMTKNT 208
             +GC  +L+KGGH+                  +  D LF    +      +  I + N+
Sbjct: 215 EKLGCANLLVKGGHIPWLNGKKFSGKDGSGQALEIVDVLFQSDEQKVTVVRSSYIESNNS 274

Query: 209 HGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           HGTGCTL++++A+   +       V  + +++   +  +   ++GHG GP++H
Sbjct: 275 HGTGCTLASSVASNLAKGIPLQLAVPLSVNYIHRGM-TSLKQKLGHGKGPLNH 326


>UniRef50_Q0VSP4 Adenine phosphoribosyltransferase n=2 Tax=Alcanivorax
           RepID=Q0VSP4_ALCBS
          Length = 253

 Score =  239 bits (610), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 86/256 (33%), Positives = 130/256 (50%), Gaps = 8/256 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK  N L IAG DPSGGAGI AD++   ALG +  ++IT L  QN++ V+     E D +
Sbjct: 1   MK-PNILVIAGHDPSGGAGIHADIEAIQALGGFASTLITGLTVQNSQNVRGFRLTEIDLL 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q D++  D+     KIGM     IV+ + + L+R     V+LD V+ A++G  L   S
Sbjct: 60  QQQADALLDDMDYQAIKIGMTGSIAIVDFITQLLKRLPNVPVILDPVLAAEAGGSLAQES 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               +   L P   ++TPNLPEA AL        +Q +   G+ L+     A L+ G H 
Sbjct: 120 LAEVMLDTLAPLCDVMTPNLPEAQALSG------QQSVSGCGQVLVQRSGCATLITGTHD 173

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D +Q  + LFT  GE+++   R+     HG+GCTL++++A LR    +    V   ++ +
Sbjct: 174 DTDQVVNHLFTPSGEEQWHWDRL-PHRYHGSGCTLASSIACLRGHGQSLHSAVANGQAHV 232

Query: 241 SSALAQADTLEVGHGI 256
              L  A     G  +
Sbjct: 233 DKFLRNAFQPGQGQYV 248


>UniRef50_A6VXY4 Thiamine-phosphate pyrophosphorylase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VXY4_MARMS
          Length = 513

 Score =  239 bits (610), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 85/264 (32%), Positives = 131/264 (49%), Gaps = 8/264 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K      + G+D S  AG+QADL+T   L  +  +++T + AQN++ V+SV  +      
Sbjct: 4   KPPVVWCVGGSDSSAHAGLQADLRTGQDLRCHVQTIVTCITAQNSKEVRSVEPVSLAMFD 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQ----RYQIQNVVLDTVMLAKS--GDP 115
            Q  ++  DV  D  K+ +L   +I +A +  L+     +    VV D VM A S  G+ 
Sbjct: 64  EQWQTLLDDVPPDAIKVSLLPSIEIAKACSIWLRRIKADFPNVLVVFDPVMAASSESGNR 123

Query: 116 LLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLM 175
           L   S  A+L   LLP + +ITPN  E   L      +   ++  Q    L+    A L+
Sbjct: 124 LQQDSVGASLLGSLLPYIDVITPNSIEFKRLTGLSDQQPAVDIQGQLAVYLSSSKCAWLL 183

Query: 176 KGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           K GH D EQ+ DWL  ++    F   R+   NT GTGCTLS ALA+      +  D +  
Sbjct: 184 KAGHSDSEQATDWLLDQDSIVGFAYKRLSVHNTRGTGCTLSTALASFIAHGYDLLDAMTM 243

Query: 236 AKSWLSSALAQADTLEVGHGIGPV 259
           AK++++ AL     +++G G GP+
Sbjct: 244 AKAYITGALKTG--VQIGEGAGPL 265


>UniRef50_UPI0001C41D57 phosphomethylpyrimidine kinase ThiD2 n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41D57
          Length = 266

 Score =  239 bits (610), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 83/268 (30%), Positives = 132/268 (49%), Gaps = 22/268 (8%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DPSGGAGI  D+KT +A G + CSVITAL AQN + V SV  IE  ++  Q+DS
Sbjct: 4   LSIAGFDPSGGAGISTDMKTMAAHGVHPCSVITALTAQNPKKVFSVQAIETSYIRQQIDS 63

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +F +  I  +K G+L   +I++ V+++++      +V+D VM+A SG  L       +L+
Sbjct: 64  IFDEYPIKYSKTGLLYSKEIIQLVSKKVEELN-LRIVVDPVMVASSGGQLAKKEMANSLK 122

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL    L+TPN+ EA  L      ++ ++  E    +    C  V++ GGHLD     
Sbjct: 123 KYLLKNALLVTPNVKEAEELSGI-SIKSIEDAKEAAYKIGE--CCNVMITGGHLDGNNVI 179

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALR--PRHTN--------WADTVQEA 236
            +   ++         I T N HGTGC+LSAA+ A        +            ++ +
Sbjct: 180 -YNKQKDELSILKQNLIKTDNLHGTGCSLSAAICANLIILNEKDKDSKDENNLEIAIERS 238

Query: 237 KSWLSSALAQADTLEVGHGIGPVHHFHA 264
             ++  A+ +          G ++    
Sbjct: 239 TKFIYEAVKKGR-------YGTLNPNFN 259


>UniRef50_A7HV13 Phosphomethylpyrimidine kinase n=9 Tax=Bacteria RepID=A7HV13_PARL1
          Length = 282

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 99/243 (40%), Positives = 141/243 (58%), Gaps = 4/243 (1%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQAD+K+ SA+G +  + +TA+  QNT GV  ++ +  D V AQ+ +V  D+  D  K 
Sbjct: 22  GIQADIKSVSAMGGFAMTAVTAITVQNTLGVHGIHEVPVDVVVAQMKAVMEDIGADAVKT 81

Query: 79  GMLAETDIVEAVAERLQRYQIQ-NVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
           GML   +IVEAVA +L        +V+D VM+AK G  LL  SAVA L+  L+P  +LIT
Sbjct: 82  GMLHSAEIVEAVAAQLSEENAPGFLVVDPVMIAKGGAALLEGSAVAALKEVLIPLATLIT 141

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQR 197
           PN+PEA  L                 +LL +GC AVL+KGGHL  +   D L T+E    
Sbjct: 142 PNVPEAEVLTG-RSITDLASQKAAADALLGLGCDAVLLKGGHLSGDTLFDVLATQETVHT 200

Query: 198 FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIG 257
           F++PRI T++THGTGC L++A+AAL  +       V+ A+ ++  A+  A     G G G
Sbjct: 201 FSSPRIDTRHTHGTGCALASAIAALLAQGVELTAAVEAARDYIHEAIRTAP--GFGKGHG 258

Query: 258 PVH 260
           P++
Sbjct: 259 PLN 261


>UniRef50_Q1MQ91 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=2
           Tax=Desulfovibrionaceae RepID=Q1MQ91_LAWIP
          Length = 277

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 102/266 (38%), Positives = 147/266 (55%), Gaps = 10/266 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
                LTIAG+D  GGAGIQADLKT + LG +G SVITAL AQN  GV  ++  +P F+ 
Sbjct: 8   NPPCILTIAGSDSGGGAGIQADLKTIAILGGFGLSVITALTAQNGLGVTGIHTPDPSFIE 67

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL++++    ++  K GML    I+E V   +++ Q    V+D V +++SG  LL  +A
Sbjct: 68  LQLNTIYKGFFVNVLKTGMLFSVPIIEIVKNIIKKQQTL-AVIDPVCVSQSGYQLLEHTA 126

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           +  LR+ +LP   L+TPN PEA  L +     +E+++   G+ L+ MG  AVL+KGGH  
Sbjct: 127 IDALRTHILPLAMLVTPNKPEAELLTEM-QIESEKDIYIAGKRLIDMGAKAVLIKGGHFY 185

Query: 182 DEQS----PDWLFTRE--GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
                    DW   +        + P I TKN HGTGCTLSAA+A            + +
Sbjct: 186 KNNLVTNYVDWYIEKNSTNPIPLSQPAIKTKNNHGTGCTLSAAIATYIGLGLELKKAILQ 245

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHH 261
           A+++L+  L    +   G GIGP +H
Sbjct: 246 AQTYLNYCLK--FSYTPGKGIGPPNH 269


>UniRef50_C3NMB3 Phosphomethylpyrimidine kinase n=14 Tax=Sulfolobaceae
           RepID=C3NMB3_SULIN
          Length = 456

 Score =  238 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 77/261 (29%), Positives = 137/261 (52%), Gaps = 9/261 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +   +T+AG D   GAG + DL+ F  LG +G   ITA+ AQ+T+G++ +  +  +F+
Sbjct: 13  MIKPVGMTVAGLDTGNGAGGETDLRVFEVLGIHGVFAITAITAQSTKGIKDINVVSSEFL 72

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q++++  D  ++  K+GM+   +  + V E L       +V+D V+ AK G PL+   
Sbjct: 73  KKQIETLLDDFNVEAVKMGMIYTKEQFQVVNELLHD---SFLVVDPVLYAKDGTPLIKD- 128

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGA-VLMKGGH 179
            V   +  +LP   +ITPN+ EA+A+      + E +++   + +      A V++KGGH
Sbjct: 129 -VEDYKKIILPIAKVITPNIIEASAISSIKVEK-ESDVVIACKKIRETYNIAHVIIKGGH 186

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              + S D++   EG  +    RI  K+THGTG   + A  A   +  +     ++A+ +
Sbjct: 187 SKGDFSFDYMCNEEGVYKIGYHRIQAKDTHGTGSVFATAFTAEYIKTKDVKLAFRKARDF 246

Query: 240 LSSALAQADTLEVGHGIGPVH 260
           + S +     L +G G+GPV+
Sbjct: 247 VQSPIEYG--LNIGKGVGPVN 265


>UniRef50_A7BQI9 Phosphomethylpyrimidine kinase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BQI9_9GAMM
          Length = 271

 Score =  237 bits (606), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 74/253 (29%), Positives = 122/253 (48%), Gaps = 5/253 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L  AG DP+GGAGI AD++  ++ G +   +IT++  Q+TR V     +    VA
Sbjct: 5   QPPIVLVFAGHDPTGGAGICADIQALASQGCHTAPIITSITTQDTRNVFENKPLSSTLVA 64

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ ++V +D+ I   KIG+L   +I+EAV   L ++    VV+D V++A  G  L     
Sbjct: 65  AQAEAVLADLPIAACKIGLLGSIEIIEAVQHLLLKHPHLPVVVDPVLVAGGGYSLTQDKV 124

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              +  +LLP   +ITPN PEA+AL           +      L+  GC  V + G H D
Sbjct: 125 RDAMIKKLLPLTQIITPNSPEASALTGIT-----NSLNAAATRLMDYGCQHVCITGTHED 179

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
                + L++   + +      +  + HG+GCT +A+LA    +  +    V +A+ +  
Sbjct: 180 TPLVKNTLYSHGQQIQSWTWTRLPHSYHGSGCTFAASLAGFLAQGIDMVTAVYKAQHYTW 239

Query: 242 SALAQADTLEVGH 254
           + L +      G 
Sbjct: 240 TTLQRGFKPGHGQ 252


>UniRef50_A5UJW6 Phosphomethylpyrimidine kinase (HMPP-kinase), ThiD n=2
           Tax=Methanobrevibacter smithii RepID=A5UJW6_METS3
          Length = 246

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 80/245 (32%), Positives = 124/245 (50%), Gaps = 7/245 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
           +  ++IAG DPSGGAGI AD+KTF ALG YG  ++TAL AQN + + S+  IE D+V  Q
Sbjct: 1   MIVMSIAGVDPSGGAGILADIKTFQALGVYGTGIVTALTAQNPQMMYSLKAIETDYVEEQ 60

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +D+V     ++  K GML   DI++ V+++++ Y ++ VV D VM+A SG  L       
Sbjct: 61  IDAVLDSYNVEYIKTGMLYSKDIIKTVSKKIREYNLKAVV-DPVMVATSGGELAKDDLSQ 119

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP+  L TPN+ EA  L        E++       L        ++ GGHL+  
Sbjct: 120 NLLKYLLPKAILTTPNVSEAEKLTGIK-IADEEKAEIACEKLGK--ICNNIITGGHLNG- 175

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
              +          F    + T N HG+GC  SAA+ +   +  +   ++ +A  +   +
Sbjct: 176 --TNITCIDGKISTFKQELLKTDNVHGSGCNFSAAIVSYLSQKNDLKTSILKASEYTYES 233

Query: 244 LAQAD 248
           +    
Sbjct: 234 IKNGK 238


>UniRef50_Q1EI25 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3 Tax=root
           RepID=Q1EI25_9ZZZZ
          Length = 284

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 102/254 (40%), Positives = 146/254 (57%), Gaps = 11/254 (4%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT +ALG Y  + +TAL AQNTRGV S++ +  DFVA Q+  V SD+  D  K+G
Sbjct: 27  IQADIKTVTALGGYAMTAVTALTAQNTRGVFSIHDVPADFVAEQMRVVLSDIGADCVKVG 86

Query: 80  MLAETDIVEAVAERLQRY-------QIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQ 132
           ML    ++EAV + L+         +   +V+D VM+AK G+ LL+P A+A+L++R++P 
Sbjct: 87  MLHTPGVIEAVCDVLEAEAEAAAGGRRVPIVVDPVMVAKGGESLLAPDAMASLKARMIPL 146

Query: 133 VSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWL-FT 191
             ++ PN+ EA AL          +     R L A G  AVL+KGGHL  E   D L   
Sbjct: 147 AHVLMPNVAEAEALTGLT-VGGPDDAGTVARKLAAAGAAAVLLKGGHLPGETVIDILAVD 205

Query: 192 REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLE 251
            E  + F +PRI T +THGTGCTL++A A    +     D V  A+ ++  A+  A    
Sbjct: 206 GEIVEVFESPRIDTPHTHGTGCTLASATATGLAQGMAVRDAVARARRYVHEAILTAP--G 263

Query: 252 VGHGIGPVHHFHAW 265
           +GHG GP++H H  
Sbjct: 264 LGHGHGPLNHAHTV 277


>UniRef50_B0Q8A3 Phosphomethylpyrimidine kinase n=1 Tax=Bacillus anthracis str.
           A0193 RepID=B0Q8A3_BACAN
          Length = 223

 Score =  235 bits (600), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 5/199 (2%)

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           + +D+  D  KIGML  ++I++ VAE + ++   N+VLD VM+AK G  LL   AV  L+
Sbjct: 20  IQADLTPDAVKIGMLFSSEIIQIVAEYINKFGWNNIVLDPVMIAKGGASLLQQEAVQALK 79

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD--DEQ 184
             LLP  ++ITPN+PEA  L         ++  E  + L  +G   VLMKGGH +    +
Sbjct: 80  EYLLPVATVITPNVPEAEVLTGL-EIHNIEDSKEAAKVLHELGAKYVLMKGGHAEYQGNE 138

Query: 185 SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
             D LF  E    F + RI +K THG+GCT ++A+ A   +  +  + VQEAK ++S A+
Sbjct: 139 VIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSMEEAVQEAKRFISIAI 198

Query: 245 AQADTLEVGHGIGPVHHFH 263
              + L +G G GP +HF 
Sbjct: 199 E--EPLHIGSGHGPTNHFA 215


>UniRef50_B8C466 Probable thiamin biosynthetic enzyme (Fragment) n=1
           Tax=Thalassiosira pseudonana RepID=B8C466_THAPS
          Length = 265

 Score =  233 bits (596), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 85/259 (32%), Positives = 131/259 (50%), Gaps = 25/259 (9%)

Query: 20  IQADLKTFSALG---AYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTT 76
           IQADLK    L     +GCS IT L AQN+ GV SV+     F+  QL+ +  D+     
Sbjct: 13  IQADLKAIHTLSNGACHGCSAITCLTAQNSCGVTSVHSPPVAFLREQLNVLEGDLYPKAV 72

Query: 77  KIGMLAETDIVEAVAERLQRYQIQN---------VVLDTVMLAKSGDPLLSPSAVATLRS 127
           K+GML   ++ E V   L++ + ++         VV+D VM++ SG  L+  +A   +  
Sbjct: 73  KVGMLGSGELAEEVGGWLRQLKEKHSGDGGVMPLVVVDPVMISTSGHKLVDDTAKKAMIE 132

Query: 128 RLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH--LDDEQS 185
           ++ P   L+TPN  EA  LL      T  ++ E    +LAMG  AVL+KGGH  ++ ++ 
Sbjct: 133 KVFPFADLVTPNKFEAEELLGRKLL-TPSDVKEGAAEILAMGAKAVLIKGGHSLMETQRV 191

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTN-----WADTVQEAKSWL 240
            D    +E      + R  T +THGTGCTLS+A+A               D    AK+++
Sbjct: 192 VD---EKEDGIWIRSERYETSHTHGTGCTLSSAIATAWAMGQPLSAMHLVDACCIAKAYV 248

Query: 241 SSALAQADTLEVGHGIGPV 259
           +  +  +  +++G G GPV
Sbjct: 249 NDGI--SKGVQLGKGPGPV 265


>UniRef50_C0N961 Thiamine-phosphate pyrophosphorylase n=2 Tax=Proteobacteria
           RepID=C0N961_9GAMM
          Length = 480

 Score =  233 bits (594), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 76/266 (28%), Positives = 128/266 (48%), Gaps = 9/266 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +   L I G DP G AGI AD+ T      +   +ITA+  Q++ G+ ++  +  + +
Sbjct: 1   MAKPAVLLIGGLDPQGCAGIAADIATVQHHDCHPLPLITAMTEQSSAGLTALGAVNTNKL 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            AQ  +  +D  I   K+G++ +  I E V + L       VV+D V+ + SG   ++  
Sbjct: 61  MAQYRNCKADFDIQAIKVGLIPDLIIAEKVKQILLDNPGIPVVMDPVLASSSGGKTVADG 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               +R  LL  ++L+TPNLPE + L D       +++ +    L   G  A L+KGGH 
Sbjct: 121 VRQYIRDELLQHLTLLTPNLPELSLLTD-----NLEDVEQATTILSQKGLQACLVKGGHA 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           D E + D+  + E  + +        +  GTGC L++A+A+      +  D V  AK+++
Sbjct: 176 DSEFATDFFIS-EQVRFYCYQTKYASDVRGTGCVLASAIASHLASGQDMRDAVVLAKTYV 234

Query: 241 SSALAQADTLEVGHGIGPVHHFHAWW 266
           S  + QA T+        + H H  W
Sbjct: 235 SRGIRQAQTVGS---YRLIKHSHEPW 257


>UniRef50_C5A6B1 Phosphomethylpyrimidine kinase (ThiD) n=2 Tax=Thermococcus
           RepID=C5A6B1_THEGJ
          Length = 428

 Score =  233 bits (594), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 71/248 (28%), Positives = 121/248 (48%), Gaps = 13/248 (5%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
            +  L +AG D  GGAG++AD++T SALG +   V+TA+  QN   V+  + +  + V  
Sbjct: 1   MMAVLIVAGLDTGGGAGLKADIETVSALGEHPLPVLTAVTYQNPFEVRGYHTLPSEVVRE 60

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
            + +V     +   KIGML   ++   V E    +     V D V+ + +   L+     
Sbjct: 61  GIRAVKDGFEVKAVKIGMLGSGEVARVVREETAGFPR---VFDPVIASSTEKKLIDD--T 115

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGGHLD 181
            +L++ L+P   ++TPN+ EA AL      R+ ++M +   +L+   G  A ++KGGHL+
Sbjct: 116 ESLKT-LVPGS-IVTPNVYEAEALASI-EIRSVEDMKKAATALVEEFGAEAAVVKGGHLN 172

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
                D L+ R     F   ++    THGTGC  S+ALA    +       V+ AK ++ 
Sbjct: 173 ---FTDVLYWRGEFYEFRGEKVE-GFTHGTGCAFSSALATFLAKGFELPKAVERAKRFVE 228

Query: 242 SALAQADT 249
            ++  +  
Sbjct: 229 GSIRFSKA 236


>UniRef50_C2HB32 Possible phosphomethylpyrimidine kinase n=11 Tax=Enterococcus
           faecium RepID=C2HB32_ENTFC
          Length = 275

 Score =  233 bits (594), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 78/267 (29%), Positives = 135/267 (50%), Gaps = 11/267 (4%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MKR   LTI G+DP  G GIQ DLKTF   G +G S +T++   +T G   +  I  + +
Sbjct: 6   MKR--ILTIGGSDPFAGGGIQTDLKTFEDFGLFGLSALTSIGVLDTNGRFILESIPSELL 63

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL S+     +D  KIG+L  ++ +  V + ++  Q   ++LD V+  K  + +++  
Sbjct: 64  ERQLASIDQMTSLDGIKIGLLNSSEAIMVVRDFIKAKQNIPIILDPVLAFKETETVINQW 123

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-H 179
            ++ L   L P V++ITPNL EAA L       +  EM+   + L A G   +++KGG  
Sbjct: 124 YISQLIEELFPLVTMITPNLAEAALLSGQALPSSLIEMIHLAKELTASGAKKIVIKGGTR 183

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           +  EQ+ D L++ +  + F+  ++ T   +G GC  S+A+ A     T+ +  V E+K +
Sbjct: 184 MAGEQAVDLLYSVDHHEVFSQKKVDTPTVNGAGCAFSSAITANLVLGTDVSKAVAESKKF 243

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++  ++    +          H  + W
Sbjct: 244 VAHCISNGVLMN--------DHTGSVW 262


>UniRef50_A5DP35 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii
           RepID=A5DP35_PICGU
          Length = 559

 Score =  233 bits (594), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 89/284 (31%), Positives = 136/284 (47%), Gaps = 28/284 (9%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    L +AG+D SGGAGI+ADLKT SA   YG + I A+  QNT+GV+S+       + 
Sbjct: 17  QLPVVLVVAGSDSSGGAGIEADLKTLSAHKVYGATCIAAITVQNTQGVRSIVETSGATIR 76

Query: 62  AQLDSVFSDV---------RIDTTKIGMLAETDIVEAVAERLQRYQ--IQNVVLDTVMLA 110
             LD+V  D           +   K GML     +E +A            +V+D VM++
Sbjct: 77  GILDAVMDDFGRKDVAAKSPLRAIKTGML-TPAALEELANIRDEVDSLGIKLVVDPVMVS 135

Query: 111 KSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDA------PHARTEQEMLEQGRS 164
            SG  L+S  ++A+   RL+    L+TPN  EA  L  A          + +E       
Sbjct: 136 TSGARLMSEDSMASYL-RLISGSFLVTPNYLEALELAKAVNLKTDGSINSIEEGKRFVLE 194

Query: 165 LL-AMGCGAVLMKGGHLDD------EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSA 217
           L  A+ C  +L+KGGH+         +  D+L        F +  I TK+ HG+GCTL++
Sbjct: 195 LRNALKCDNLLVKGGHIPGFSGESERRIYDFLNQNGKLTVFESHYIDTKDNHGSGCTLAS 254

Query: 218 ALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
           AL+A    +    + V  A  ++  A++  + L  G G GP++H
Sbjct: 255 ALSAHIALNRPVEEAVPLALDYIHHAMSNFEKL--GRGNGPLNH 296


>UniRef50_O94265 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
           n=1 Tax=Schizosaccharomyces pombe RepID=THI21_SCHPO
          Length = 506

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 80/280 (28%), Positives = 131/280 (46%), Gaps = 21/280 (7%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             +T+AG+D SGGAG+QADLK F+A   YG S +TA+ +QNT GV  V+ I   +V  Q+
Sbjct: 4   TCITVAGSDCSGGAGVQADLKVFTAHSVYGMSAVTAITSQNTIGVNGVHLIPASYVEQQI 63

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            +   DV  +  K GML    I++ + E + R++I+ VV+D ++  + G  L+ P  +  
Sbjct: 64  SACLLDVHCEVMKTGMLFNQQILKVIVESIDRFKIKKVVVDPLIATRKGALLVMPDYLEL 123

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAP-----HARTEQEMLEQGRSLLAMGCGAVLMKG-- 177
               L+P+  ++ PN+ EA  +L             +++   G+ L+  GC  V+++   
Sbjct: 124 FVKELIPRAEVLIPNIAEALIILKHMTNEFVEIHHLEDVKAVGKKLIKAGCKNVVIRCDD 183

Query: 178 GHLDDEQSPD------------WLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR 225
                +                 L T EGE       + +K   GT C LS+A+A+    
Sbjct: 184 IPFASDFFCSRETNMPPTWYLYVLCTSEGEVLLPQKWLASKTARGTSCALSSAVASNLAI 243

Query: 226 HTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
             +     Q A S+   AL  +  L  G G   + +  A 
Sbjct: 244 GLDLVTATQNAVSYTQRALEMSFHL--GRGANSLDYASAL 281


>UniRef50_A2RIH2 Phosphomethylpyrimidine kinase n=8 Tax=Streptococcaceae
           RepID=A2RIH2_LACLM
          Length = 262

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 73/253 (28%), Positives = 126/253 (49%), Gaps = 8/253 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LTIAG+D   G G+QADL TF+A G YG   +T++V         V+ ++ +    +
Sbjct: 9   KKILTIAGSDILSGGGMQADLATFAANGLYGFCALTSIVTVKEDKFF-VHPVDEEIFQEE 67

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ---IQNVVLDTVMLAKSGDPLLSPS 120
           L+S+  D+     KIG+L    I+E   + L          ++LD V++ K         
Sbjct: 68  LESLT-DIDFSAIKIGLLPNKKILEMTKKWLTALSVKSPVPIILDPVIVFKENADYSVSE 126

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH- 179
                 S+L P  ++ITPNL EA  L      +TE +M    + L   G   V++KGG+ 
Sbjct: 127 MRELFISQLFPLATVITPNLKEAEILTGL-SVKTEADMKAAAKLLHRFGAKNVIIKGGNR 185

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            D +Q+ D+ +  +   +  +P +  KN +G GCT ++++A+      ++ D+V++AK +
Sbjct: 186 FDQKQAIDFAYDGKDFYQLASPLLQ-KNNNGAGCTFASSIASQMAEENSFKDSVEKAKDF 244

Query: 240 LSSALAQADTLEV 252
           +  A+  A+   V
Sbjct: 245 VYQAIQNANEFGV 257


>UniRef50_Q0F2B9 Phosphomethylpyrimidine kinase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F2B9_9PROT
          Length = 253

 Score =  231 bits (591), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 97/246 (39%), Positives = 127/246 (51%), Gaps = 3/246 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M R   LTI G+D  GGAGIQADL+ F  LG YGCS ITAL AQN   +  +  +    +
Sbjct: 6   MARPVCLTIGGSDSCGGAGIQADLRVFDRLGVYGCSAITALTAQNPLHIARIEPVSLAQL 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            A+L ++F    +   K GML + + V  V+  L      ++V+D VM++ SG  LL   
Sbjct: 66  DAELHALFDYYDVAVVKTGMLLDAEHVAVVSGLLAELHHGSLVVDPVMISSSGSVLLDQG 125

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            VA LR  LLPQ +LITPNL EA ALL  P        +E  ++L       VL+KGGH 
Sbjct: 126 GVAALRGALLPQAALITPNLDEADALLGQPSGYAADSPVEAVKALREALGCPVLLKGGHA 185

Query: 181 DDEQSPDWLFT-REGEQRFTAPRI--MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
           D +   D L    EG  RFT  R        HGTGC L++A+AA           V+ A 
Sbjct: 186 DGDMLLDLLCDEEEGIHRFTHIRQCWSAGEGHGTGCRLASAVAAGLANQMPLVPAVEAAI 245

Query: 238 SWLSSA 243
           ++L   
Sbjct: 246 AFLQEC 251


>UniRef50_A5FWQ5 Phosphomethylpyrimidine kinase n=1 Tax=Acidiphilium cryptum JF-5
           RepID=A5FWQ5_ACICJ
          Length = 272

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 91/245 (37%), Positives = 138/245 (56%), Gaps = 4/245 (1%)

Query: 21  QADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM 80
           +AD+KT +ALG Y  + ITA+ AQ+T G+ ++  + PD VA  +  V +D+ +D  K+GM
Sbjct: 21  EADVKTITALGGYAMTAITAVTAQDTSGIAAIAPVPPDLVARSIRMVVADLGVDAIKLGM 80

Query: 81  LAETDIVEAVAERLQRYQIQNVV-LDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           L      E VA  +        + LD V+ + SG  L    A+A +R RLLP+ +L+TPN
Sbjct: 81  LGSAGTAEEVALAIAAAAPAAPLVLDPVLASTSGTALAGEGALAIIRDRLLPRATLVTPN 140

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFT 199
             EAA L       + ++ +  GR+L  +G  AVL+KGGH D +   D L   +    F 
Sbjct: 141 RDEAATLAGLA-IDSHEDAIRAGRALCRLGARAVLLKGGHFDGDPVIDRLIAGDDVVTFA 199

Query: 200 APRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
            PRI T++THGTGCTL++A+A    R  +    ++ A+++L +AL  A    +G G GP+
Sbjct: 200 HPRIATRHTHGTGCTLASAIACGLARGLDLRAAIEAAEAFLHAALRAAP--GLGRGHGPL 257

Query: 260 HHFHA 264
            H  A
Sbjct: 258 GHARA 262


>UniRef50_C5SEE1 Phosphomethylpyrimidine kinase n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SEE1_CHRVI
          Length = 272

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 80/257 (31%), Positives = 119/257 (46%), Gaps = 11/257 (4%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L + G DPSGGAGI AD +   A  A+  +VITAL  Q+T G+  ++   P+ + A
Sbjct: 9   RPLVLCVGGHDPSGGAGILADAEVVQAARAFPLTVITALTEQDTCGLAQIHPQPPEQIEA 68

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERL-----QRYQIQNVVLDTVMLAKSGDPLL 117
               + SD      KIG++   DI   +A  +            VVLDTV+   +G  + 
Sbjct: 69  HCRRLLSDSPPSALKIGLIGGADIARMLARFIDTLATAERARVPVVLDTVLATGAGQSVA 128

Query: 118 SPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKG 177
             +    +R  L+P+ +L+TPNLPEA AL             +    LLA G   VL+ G
Sbjct: 129 DAALREAVREALIPRCTLVTPNLPEARALTG------ADAPEDCAERLLAAGAPWVLITG 182

Query: 178 GHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            H   E   + LF   GE+       +    HG+GCTL++A+AA           V+ A+
Sbjct: 183 THDATEAVTNRLFGSNGERHAWDWPRLPGEYHGSGCTLASAIAARLAHGMTLIQAVESAQ 242

Query: 238 SWLSSALAQADTLEVGH 254
           ++  +AL +A       
Sbjct: 243 AYTWTALERALRTGRCQ 259


>UniRef50_Q2GJ96 Phosphomethylpyrimidine kinase n=1 Tax=Anaplasma phagocytophilum HZ
           RepID=Q2GJ96_ANAPZ
          Length = 265

 Score =  230 bits (588), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 94/264 (35%), Positives = 146/264 (55%), Gaps = 6/264 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M + N L+IAG+D  GGAGIQAD+KT + LG Y  + ITA+ AQNT+ V+ V+ + P+ V
Sbjct: 1   MYKGNVLSIAGSDSGGGAGIQADIKTITMLGCYAATCITAITAQNTQEVRGVWELAPEVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL++V  D+++D  KIGML    ++  VAE L       V+LD VM++ SG  L  P 
Sbjct: 61  KGQLEAVLDDLKVDAIKIGMLP-VGLIGVVAESLPC--EIPVILDPVMVSTSGFELTDPM 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGH 179
                   L    +L+TPN+ E  AL    + RT +EM+  G  ++  +G  AVL+KG  
Sbjct: 118 GYTESIRPLAQNAALVTPNIKETEALSGMKNIRTREEMVTAGNKIIQFLGIKAVLVKGCI 177

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            ++E+  + +   +G+  F          HGTGCTL++A+A    R  +  ++ + A  +
Sbjct: 178 WEEEEFVESVLIYDGKTVFFRNERAPGELHGTGCTLTSAIACFIARGLSLEESTRLAFDY 237

Query: 240 LSSALAQADTLEVGHGIGPVHHFH 263
           +S  +  A    VG G+ P+ H +
Sbjct: 238 VSCTIRNAPI--VGQGLRPLFHNY 259


>UniRef50_P66914 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=17
           Tax=Actinomycetales RepID=THID_MYCBO
          Length = 265

 Score =  230 bits (588), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 101/267 (37%), Positives = 147/267 (55%), Gaps = 5/267 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L+IAG+D  GGAGIQAD++T + LG + C  +TA+  QNT GV+ ++ +  D V
Sbjct: 1   MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSP 119
           A Q+++V +D+ +   K GMLA + IV  VA   +R +    +V+D V  +  GDPLL+P
Sbjct: 61  AGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
           SA+ +LR +L P  +L+TPNL EA  L+D       +      ++L A+G   VL+KGGH
Sbjct: 121 SALDSLRGQLFPLATLLTPNLDEARLLVDIEVV-DAESQRAAAKALHALGPQWVLVKGGH 179

Query: 180 L-DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
           L   + S D L+      +F A R+ T + HG G TL+ A+AA         D V   K 
Sbjct: 180 LRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKR 239

Query: 239 WLSSALAQADTLEVGHGIGPVHHFHAW 265
           W++  L  A    +G G GPV      
Sbjct: 240 WVTECLRAA--YPLGRGHGPVSPLFRL 264


>UniRef50_D1N338 Phosphomethylpyrimidine kinase n=1 Tax=Victivallis vadensis ATCC
           BAA-548 RepID=D1N338_9BACT
          Length = 281

 Score =  229 bits (586), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 86/233 (36%), Positives = 130/233 (55%), Gaps = 4/233 (1%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           I+ADL+TF+A G YGC+ +TA+ +QN   V+ +  I  + V  Q+++V   + +   K G
Sbjct: 28  IEADLRTFNAYGVYGCAALTAVTSQNPAEVRRIDAIPAEGVRCQIETVLDRIPVRAVKSG 87

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML    IVEAVAE +++ +   +V D VM++ SG  LL   AVA +R  LLP  + ITPN
Sbjct: 88  MLFNAAIVEAVAEVVKQRR-LMLVCDPVMVSTSGAALLEKEAVAKVRELLLPVAAWITPN 146

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH-LDDEQSPDWLFTREGEQRF 198
           LPEA  LL     +T  +  +  +        AVL+K GH L  +   D++         
Sbjct: 147 LPEAELLLG-RELKTADQFADAAKECFDRWGAAVLLKTGHALSGKFVTDFVCREGKIYTL 205

Query: 199 TAPRIM-TKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTL 250
           +APR+     +HGTGCTLS+ALAA       W   V EAK++++ +L ++  +
Sbjct: 206 SAPRVPENGASHGTGCTLSSALAAGFALEMPWKQAVCEAKAFVTGSLRESVPI 258


>UniRef50_Q38VX7 Putative phosphomethylpyrimidine kinase n=1 Tax=Lactobacillus sakei
           subsp. sakei 23K RepID=Q38VX7_LACSS
          Length = 264

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 80/253 (31%), Positives = 125/253 (49%), Gaps = 1/253 (0%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D  GG G+QADLKTF A G +G S +T L          +  IE + V AQ+
Sbjct: 3   NILTIAGSDTLGGGGLQADLKTFEAFGHFGVSAVTCLATVMPDQTFQIQNIETETVLAQI 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +++   V + T KIG++ +   +E +   LQ+     ++ D V+  K     L    + +
Sbjct: 63  EAILHYVPLTTIKIGLINDATTLEKIGHLLQKQPHLQIITDPVLAFKETTDKLQQHYLDS 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L+  LLPQ  ++TPNL EA  L   P  +T  E+ +    + ++G   V++KGG     +
Sbjct: 123 LKDVLLPQSLVVTPNLVEAQLLSGLPQIQTRAELEQAATIIQSLGPQHVVIKGGQRFPGD 182

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D L +       +APR+ +   +G GCTLSAA+ A           V+ AK ++   
Sbjct: 183 DAIDLLHSGTTNHYLSAPRLTSATRNGAGCTLSAAITAEIASGHAVYPAVKAAKQFVYHG 242

Query: 244 LAQADTLEVGHGI 256
           +     L  G G 
Sbjct: 243 IQNGIQLRHGFGN 255


>UniRef50_Q04326 H.polymorpha DL1 DNA for region containing 9 open reading frames
           n=3 Tax=Pichia angusta RepID=Q04326_PICAN
          Length = 379

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 89/287 (31%), Positives = 132/287 (45%), Gaps = 31/287 (10%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT+AG+D SGGAGI+AD+KT +A   Y  + ITAL AQN+ GV +V     + V   
Sbjct: 33  PRVLTVAGSDSSGGAGIEADVKTITAHKCYAVTCITALTAQNSLGVHNVTTTPAETVEKV 92

Query: 64  LDSVFSD-VRIDTTKIGMLAETDIVEAVAERLQRYQI-QNVVLDTVMLAKSGDPLLSPSA 121
           L ++  D + +D  K+GML + + +  +   L        +VLD V +AK+GD L S  A
Sbjct: 93  LVAIADDQIALDAIKLGMLPD-ETLSVITPFLAARAARTPIVLDPVFVAKNGDRLSSVGA 151

Query: 122 VATLRSRLLPQVSLITPNLPEAAALL----------DAPHARTEQEMLEQGRSLLAMGCG 171
           +      L    +LITPN  E   LL          +     T  +     R L +    
Sbjct: 152 LKKAVE-LFQHAALITPNSREVEVLLAVLRSSDPSVEEITITTADDFYTAARLLGSRFKV 210

Query: 172 AVLMKGGHLDDEQ-----------SPDWLFTR--EGEQRFTAPRIMTKNTHGTGCTLSAA 218
            VL KGG +   +             + L+    E    F +  I + N HGTGCTLS+A
Sbjct: 211 DVLFKGGLVPVNENLAVDPENPVYILNVLYEHRSEKLTVFRSNHIDSPNLHGTGCTLSSA 270

Query: 219 LAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAW 265
           +A    R  + A  V+ A  +++ A+  A+        GP++H  A 
Sbjct: 271 VACYLARGASLATAVENAIGFVNEAIRHAEV----KPNGPLNHTWAI 313


>UniRef50_A0RU47 Hydroxymethylpyrimidine phosphate kinase n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RU47_CENSY
          Length = 438

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 87/258 (33%), Positives = 124/258 (48%), Gaps = 7/258 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT+AG+DPS GAGIQ DL T S +G  G SVITA+ AQN+ G      +    VA Q
Sbjct: 7   PYVLTVAGSDPSSGAGIQGDLGTISRMGCTGLSVITAITAQNSSGFTGAEPVPTSMVALQ 66

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           + +V SD  +   K+GM+    ++ AV+  L+      VVLD VM + +G  LL  +A+ 
Sbjct: 67  MQAVLSDYDVSAVKVGMVLTVPVIRAVSRGLEELD-VPVVLDPVMHSTTGGRLLDDAALP 125

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   L+ +  ++TPN  E A L     A T  +       LL  G GAV + G      
Sbjct: 126 ALSKHLVSRADVVTPNASELAVLSGMK-AGTAVQARTAATKLLDRGAGAVAVTGL-AGRG 183

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
           +  D + T +     +  RI  ++ HG GC  SAA+AA   R        +EA      +
Sbjct: 184 KIYDQVVTSKEHFEVSGRRIRGES-HGGGCAYSAAMAASLARGMGLKAAAREAAEHSRRS 242

Query: 244 LAQADTLEVGHGIGPVHH 261
           +A   +   G G+  V H
Sbjct: 243 IASTRS---GRGLPTVSH 257


>UniRef50_B9ZRE6 Phosphomethylpyrimidine kinase n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZRE6_9GAMM
          Length = 262

 Score =  228 bits (583), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 93/255 (36%), Positives = 137/255 (53%), Gaps = 10/255 (3%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              ALTIAG+DP GGAG+QADL TF+ LG +G + +TA+  Q+TR V     + P+ + A
Sbjct: 4   PPIALTIAGSDPGGGAGLQADLTTFTRLGVHGATAVTAITVQDTRNVVDFTVLPPEQLRA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q++   +D+ +   KI ML   + V  ++  L  +    VVLD VM+A  G  L + + V
Sbjct: 64  QIEVTLADLEVAAIKISMLGSVENVTVISALLGAHPHIPVVLDPVMVAGGGGALATEAVV 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
              R  LLP+ +LITPN PEAA L         ++  + G  L  +G   VL+ GGH   
Sbjct: 124 DATREALLPRATLITPNGPEAARLA------RSEDPAQWGHQLRQLGARNVLVTGGHEGT 177

Query: 183 EQ--SPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           EQ    + L+  +   R F  PR      HG+GCTL+AA+AA   R  +    V EA+++
Sbjct: 178 EQDPIINRLYREDDHVRPFELPRHPAG-FHGSGCTLAAAIAAFLARGRDIEPAVIEAQAF 236

Query: 240 LSSALAQADTLEVGH 254
           ++ A+A+      G 
Sbjct: 237 MNDAIARGYAPGRGQ 251


>UniRef50_O85786 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=26
           Tax=Bacteria RepID=THID_SYNE7
          Length = 263

 Score =  228 bits (583), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 101/267 (37%), Positives = 144/267 (53%), Gaps = 5/267 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M    ALTIAG+D  GGAGIQADL+TF+    +G   IT + AQNT GV  V  I P  V
Sbjct: 1   MAVPIALTIAGSDSGGGAGIQADLRTFAFHQVHGTCAITCVTAQNTLGVTRVDAIAPAGV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           AAQLD+V SD+     K GML   +I+E VA  +        ++D VM++++G  L+  +
Sbjct: 61  AAQLDAVLSDLPPQALKTGMLLNAEIMEVVAGTIAPL-FIPRIIDPVMVSRTGAVLIDQA 119

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+A LR  LLP  +++TPN  EA  L      +   ++    R +  +G  AVL+KGG  
Sbjct: 120 AIAVLRDHLLPLATVLTPNRYEAQLLAGMD-IQDAADLDRAARIIRDLGPQAVLIKGGAA 178

Query: 181 DDE-QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
             +    DW +  +         I T +THG+GCTL+AA+AA            Q AK +
Sbjct: 179 TGDWHGVDWWWDGQQSHILKTEAIATPHTHGSGCTLAAAIAANAALGLEILAAAQAAKHY 238

Query: 240 LSSALAQADTLEVGHGIGPVHHFHAWW 266
           ++ AL  +  L +G G GP+ HF+  +
Sbjct: 239 VTKALRHS--LAIGQGQGPLGHFYPLF 263


>UniRef50_A7JV63 Thiamine-phosphate pyrophosphorylase n=2 Tax=Mannheimia haemolytica
           RepID=A7JV63_PASHA
          Length = 509

 Score =  228 bits (582), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 85/257 (33%), Positives = 124/257 (48%), Gaps = 10/257 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
              T+AG+D   GAG+Q DL TF      GCSV+T++ AQ+  GV  V  ++      Q 
Sbjct: 13  VIWTVAGSDSCAGAGLQTDLHTFHDFNLVGCSVVTSVTAQHPHGVLCVTPVDDHTFRQQF 72

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI-----QNVVLDTVMLAKSGDPLLSP 119
           +++      +  KIG+L     VE + E +Q+ +        VV D V +A SG  L   
Sbjct: 73  EALLVQGYPNAIKIGLLCSQAQVEILCEYIQKIRAESSHYCYVVYDPVAVASSGQALSDS 132

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +  ++ +L P V LITPN  E A L D    +T  ++      L A G  AVL KGGH
Sbjct: 133 ILLQIVQQKLYPLVDLITPNGTELALLSD-TEIQTFGDVKTASHKLFAQGIKAVLAKGGH 191

Query: 180 LD--DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            +   E   D+L T      F+  R  + NTHGTGCT ++A+ A+     + AD V  A 
Sbjct: 192 FEWLGETVRDYLLTANEIYAFSHARQQSVNTHGTGCTYASAVGAMLATGFDLADAVTVAT 251

Query: 238 SWLSSALAQADTLEVGH 254
           ++L   L  ++    G 
Sbjct: 252 AYLQKGL--SEKQGRGQ 266


>UniRef50_A8EVM9 Phosphomethylpyrimidine kinase n=1 Tax=Arcobacter butzleri RM4018
           RepID=A8EVM9_ARCB4
          Length = 251

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 85/262 (32%), Positives = 138/262 (52%), Gaps = 15/262 (5%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D  GGAGIQAD+K+    G +  + ITA+  QNT GV +V  ++P FV
Sbjct: 1   MK--VVLTIAGSDSGGGAGIQADIKSGFYHGIFMTTAITAITVQNTLGVTNVEVLKPSFV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             Q+ SV  D +++  KIGML   +++  V + ++      ++LD V ++++G  L+   
Sbjct: 59  QEQISSVLEDFKVNAIKIGMLGSKELILKVLDCIKPL-YIPIILDPVAISRAGSKLIDDE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+ TL++ L     +ITPN  EA    D       + +              +L K    
Sbjct: 118 AIETLKT-LFKYAFVITPNKYEAKLFFDVNSIDDIKNIKHI--------PTNILFKNMVE 168

Query: 181 DDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           D  ++ D L  ++G    F + R    NTHGTGC+ SA++A+L  +     D+++ AK +
Sbjct: 169 DKNKTVDVLLKKDGTIINFESKRADESNTHGTGCSFSASIASLVAKGETLEDSIKIAKKY 228

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+  A    +G+G GP++H
Sbjct: 229 IYEAIKHAP--NLGNGNGPINH 248


>UniRef50_Q2SQL4 Thiamine monophosphate synthase n=1 Tax=Hahella chejuensis KCTC
           2396 RepID=Q2SQL4_HAHCH
          Length = 487

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 85/257 (33%), Positives = 127/257 (49%), Gaps = 8/257 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
                IA +D +G +GIQADL T   L  +G   +TA+ AQN++ V S+  +    +  Q
Sbjct: 6   PKVWIIAASDSAGASGIQADLATLRGLEVHGGVALTAVTAQNSQEVLSINPVATAVLRDQ 65

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L ++ +D      KIG+L + + V+ + E L  Y    VVLD V+ + +G          
Sbjct: 66  LRALRADGDAVAIKIGLLTDAEQVDVLREFLCAYSGL-VVLDPVLGSSTGAGF---GMSV 121

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD-D 182
                LLP V ++TPN+PEA  L D     +  +ML     L  +G   V +KGGHL   
Sbjct: 122 AALKSLLPYVDVVTPNIPEAEQLADRR-ISSPADMLSAAVRLRELGAKGVWLKGGHLGLG 180

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           EQ  D ++  E    F  PR+  ++  GTGCTL++ALAA   R  +  D    A +++  
Sbjct: 181 EQCLDLVWLSEQPYWFAQPRLSVRHHRGTGCTLASALAAFVARGESLLDAAALANAYVKQ 240

Query: 243 ALAQADTLEVGHGIGPV 259
            L Q     +G G GP+
Sbjct: 241 GLRQG--YAIGPGPGPI 255


>UniRef50_Q1NV70 Phosphomethylpyrimidine kinase n=3 Tax=delta proteobacterium MLMS-1
           RepID=Q1NV70_9DELT
          Length = 288

 Score =  226 bits (577), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 100/275 (36%), Positives = 141/275 (51%), Gaps = 21/275 (7%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG+DP+GGAGIQADLKT +ALG YG + IT +  QN++GV+    +E   V  Q+ +
Sbjct: 10  LSIAGSDPAGGAGIQADLKTCTALGVYGAAAITCVTVQNSQGVRYFEPLEQQLVYDQIRA 69

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           V  D+ I   KIGML    + +AVA  L  +    +V D V+ A  G  LL  +A+  L 
Sbjct: 70  VLVDLPISHIKIGMLGSAQVADAVAAALHDF-TGVIVYDPVLKAGDGHTLLPATALQRLA 128

Query: 127 SRLLPQVSLITPNLPEAAALL-----------DAPHARTEQEMLEQGRSLLAMGC--GAV 173
           + LL ++++ITPNLPE A L              P        L     LL       AV
Sbjct: 129 ADLLSKITVITPNLPELATLDRLLPQPPGQAPSLPAGIGADSPLTAAARLLQRFPRLQAV 188

Query: 174 LMKGGHLDD--EQSPDWLFTREG-----EQRFTAPRIMTKNTHGTGCTLSAALAALRPRH 226
            + GGH +   ++  DWL TR         R   PR+ + N HGTGCT + ALAA     
Sbjct: 189 ALTGGHAEPEYDELTDWLLTRGEGQQLKVTRVEHPRLKSGNLHGTGCTFATALAACHLLS 248

Query: 227 TNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHH 261
            ++   ++ A  + S+A+     L +G G GP+ H
Sbjct: 249 GDYQRAMRRAVDFTSAAIKAGAGLSMGGGNGPLAH 283


>UniRef50_Q5KEL1 Phosphomethylpyrimidine kinase, putative n=3 Tax=Filobasidiella
           neoformans RepID=Q5KEL1_CRYNE
          Length = 561

 Score =  226 bits (577), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 106/314 (33%), Positives = 143/314 (45%), Gaps = 57/314 (18%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + +TIAG+D  GGAGIQADLKT  A G YG SV+T L AQNT GVQ+V+ +  DFV  
Sbjct: 14  RPHVMTIAGSDSGGGAGIQADLKTIEAFGCYGSSVLTGLTAQNTLGVQAVHVVPTDFVIQ 73

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL SV SD      K+GML     + A+A  + +     +VLD VM++ SG  LL   A+
Sbjct: 74  QLQSVISDELPKAIKLGMLTCASTIRALAREVSKLNTT-IVLDPVMISTSGHTLLPDDAM 132

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDA-PHARTEQEMLEQGRSLLAMG-CGAVLMKGGHL 180
             L   L P V  +TPN+PEA  L       +   +M+E  +         +VL+KGGH 
Sbjct: 133 EALYE-LYPHVDYLTPNIPEAKNLSGWSHEIKNLDDMIELAKKTNETTKSPSVLLKGGHA 191

Query: 181 --------------------------------------------DDEQSPDWLFTREGEQ 196
                                                         +   D L       
Sbjct: 192 IVSREEVLKYAGKYELIWEEGDDEDDAVEVYNEYKESLDINIKTQKDLVVDLLIKEGEII 251

Query: 197 -RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT------VQEAKSWLSSALAQADT 249
             F   ++ +++THGTGCTLSAA+A      +  AD        + A  +  SA+A A  
Sbjct: 252 AMFVGKKVDSQSTHGTGCTLSAAIACSIAVSSEVADAKSLISVFKRAIGYTQSAIATA-- 309

Query: 250 LEVGHGIGPVHHFH 263
              GHG GP++H H
Sbjct: 310 FPFGHGHGPLNHGH 323


>UniRef50_B6K6F0 Phosphomethylpyrimidine kinase n=1 Tax=Schizosaccharomyces
           japonicus yFS275 RepID=B6K6F0_SCHJY
          Length = 376

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 77/265 (29%), Positives = 130/265 (49%), Gaps = 21/265 (7%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   LT+AG+D SGGAG+QADLK   A   YG SV+T + +QN+ G+  V+ I    +  
Sbjct: 64  RPVCLTVAGSDSSGGAGLQADLKAILAHKVYGMSVVTCITSQNSTGLHDVFPIPAPLIEQ 123

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++  +DV     KIGML++ D ++AV   L RY+++NVV+D+V++   G+ +    A+
Sbjct: 124 QFNACLADVECHAVKIGMLSDVDSIQAVVRALDRYKVKNVVMDSVIVTNRGNVMCQKRAL 183

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEML------EQGRSLLAMGCGAVLMK 176
            +L   L+P+V +   N+ EA  L+     R+   M       +    L  +G   V++K
Sbjct: 184 RSLIRDLIPRVLVFGSNIMEACLLVKGATGRSFTSMRSFGDICKLLEELWKLGPKYVILK 243

Query: 177 GGHLDDEQ---------------SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAA 221
           G H+  +                + D ++          P +   N  GT C+L+A++A+
Sbjct: 244 GHHVAFDNRLRIVENASQRQPLWTIDTVYDGSQIYIVHKPYVSNYNVRGTSCSLTASVAS 303

Query: 222 LRPRHTNWADTVQEAKSWLSSALAQ 246
                      +++A S +  AL  
Sbjct: 304 NLALGKPPLIAIRDAISMVEIALEH 328


>UniRef50_A9IRG3 Phosphomethylpyrimidine kinase n=5 Tax=Bartonella
           RepID=A9IRG3_BART1
          Length = 259

 Score =  225 bits (574), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 77/241 (31%), Positives = 124/241 (51%), Gaps = 1/241 (0%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
            + L +AGTDP+GGAGI  D++T +         IT +  Q+   V  +  +    +AAQ
Sbjct: 12  PSILIVAGTDPTGGAGIVRDIETAAYFHIKANLAITCVNVQDDHHVAEIVPMNEKLIAAQ 71

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +        I   KIGM     I+ A+   L+ Y    V+LD V++A SG  L +   + 
Sbjct: 72  MRIALEANPIRAIKIGMTGNQAIIAAICRVLEDYPHIPVILDPVLVASSGGKLTTEKIIE 131

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            + ++LLP V+L+TPN  E A L   P A   +E ++Q + LL++G  ++L+KGGH +  
Sbjct: 132 IMINQLLPYVTLLTPNRDELALLSQTPLASHHEETIQQAKKLLSLGARSILVKGGHAEGP 191

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            + D    +      +APR+      GTGC LS+A+AA    +      V++AK++  + 
Sbjct: 192 LAIDSFIDKMEVINISAPRLKGT-MRGTGCILSSAIAAHLALNEPLISAVKKAKAYTHTL 250

Query: 244 L 244
           L
Sbjct: 251 L 251


>UniRef50_B4U779 Phosphomethylpyrimidine kinase n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U779_HYDS0
          Length = 259

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 72/251 (28%), Positives = 135/251 (53%), Gaps = 6/251 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK I  L  AG D + GAG+ AD +T + +GA+   + T+ V QNT+GV+ V  +EPD +
Sbjct: 1   MKSI-VLVFAGYDQTSGAGVIADARTITCIGAHPVCITTSFVIQNTKGVKEVIFLEPDII 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
              +D +  DV+    KIG++ +   +  +++ +   + ++VV+DT + +K+  PL    
Sbjct: 60  KKHIDIL--DVKPKVVKIGVVGDDKAIRLISKAIDTLKPEHVVVDTPLFSKNDTPLFKS- 116

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +   +  ++ + ++ITPN+ EA+ +      +T+ ++ +     L MG   V++KGGH 
Sbjct: 117 -LELYKDLIVSKATIITPNIKEASFITGID-IKTKNDIEQAANVFLDMGVKHVVIKGGHR 174

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           +DE   D+  + E         I T+ THGTGC  ++++A+      +   ++ +AK ++
Sbjct: 175 EDEPGVDFYKSMEESFEIKKDFIETRTTHGTGCVYASSIASYLAIGNDVKASIIKAKDYV 234

Query: 241 SSALAQADTLE 251
             A+ Q   L 
Sbjct: 235 DRAIKQGYMLN 245


>UniRef50_B9D1C6 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9D1C6_WOLRE
          Length = 260

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 89/264 (33%), Positives = 133/264 (50%), Gaps = 15/264 (5%)

Query: 1   MKRIN--ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPD 58
           MK      L IAG+D  GGAGIQAD+KT  A G Y  + ITAL AQNT GV +V  + P+
Sbjct: 1   MKNPKKNILIIAGSDSIGGAGIQADIKTCEAYGCYSATAITALTAQNTSGVSAVMPVTPE 60

Query: 59  FVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
           F+ AQL++V ++++ D  KIGML    ++  V   L++ +  + V+D V +AKSG  LL 
Sbjct: 61  FLNAQLEAVCAELKFDAVKIGMLFNEQLIACVKAWLEQNRGISAVIDPVCVAKSGAKLLQ 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
             A+  L+  LL    + TPNL EA  L        + E L  G  L       +++K  
Sbjct: 121 DGAINALKE-LLSLARIATPNLDEARIL----GLNFDGERLNLGADL----PCDIVLKRT 171

Query: 179 HLDDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
               E   D L+ + GE   F  P       HG GC+ + A+A       +    ++ AK
Sbjct: 172 QT-SEICEDTLYQKSGEIVKFGEPLERPTIMHGAGCSFATAIACALACGADEITAIKHAK 230

Query: 238 SWLSSALAQADTLEVGHGIGPVHH 261
           +++++A+  A     G  +  + H
Sbjct: 231 AFVANAIKNAHGSNFG--VRLLDH 252


>UniRef50_B9LWE4 Phosphomethylpyrimidine kinase n=13 Tax=cellular organisms
           RepID=B9LWE4_HALLT
          Length = 461

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 105/264 (39%), Positives = 144/264 (54%), Gaps = 5/264 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
            R   LTIAG+D  GGAGIQADLKT  A GA+G S ITA+ AQNT GV S + +  + + 
Sbjct: 17  SRPVVLTIAGSDSGGGAGIQADLKTIEAGGAFGTSAITAVTAQNTLGVVSSHVLPIEEID 76

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           AQ+D+V SD  +   K GMLA   ++  V E         VV+D VM+A +GD LL+P A
Sbjct: 77  AQIDAVLSDFDVRAVKTGMLATAPVIAVVTEY-VDDLDVPVVVDPVMVAATGDRLLAPDA 135

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              +   LL   +L TPN  EA  L         +  ++ G++LL  G  A L+KGGH+ 
Sbjct: 136 -ENVYEDLLAHAALTTPNADEAEVLTGI-ELTDHEGTIQAGKALLETGVDAALVKGGHVP 193

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            ++  D L T +  + +  PR+ T  THG+GCTL++A+          AD V    S++ 
Sbjct: 194 TDRVRDVLVTADDVKTYEHPRVDTDATHGSGCTLASAITTRLAHDEPLADAVDAGVSFIE 253

Query: 242 SALAQADTLEVGHGIGPVHHFHAW 265
            A+     L+VG G G VHH  A 
Sbjct: 254 RAVRY--HLDVGEGPGSVHHMVAL 275


>UniRef50_A6GQ01 Phosphomethylpyrimidine kinase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQ01_9BURK
          Length = 277

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 84/253 (33%), Positives = 121/253 (47%), Gaps = 9/253 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              LT + +DP+ GAG+QAD  T SALGA+  +++T L AQNT GV       PD++  Q
Sbjct: 6   PLVLTFSASDPTAGAGLQADALTVSALGAHPLTILTGLTAQNTAGVARFEACTPDWIDDQ 65

Query: 64  LDSVFSD-VRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           L ++  D +     K G+L  T  V AV +    +    +V+D V  +  GD        
Sbjct: 66  LTALLDDGISPSAIKTGVLGSTAAVAAVLKAKSLWPSVPLVVDPVRASGRGDAFGGQGLF 125

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
              R++L P V L+TPN PEA A   A          E G  LL MGC AVL+KG HL+ 
Sbjct: 126 DYYRNQLFPAVDLLTPNWPEAQAFTGAQTVD------EAGERLLKMGCKAVLLKGEHLES 179

Query: 183 EQSPDWLFTREG-EQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
               + L+        F   R+     HG+GCTL++A A    +  +  + V+ A  +  
Sbjct: 180 GDIVNRLYRPGQPVVEFPCERL-PGQYHGSGCTLASACAVGLGQGLSVQEAVELALEYTW 238

Query: 242 SALAQADTLEVGH 254
            AL+    +  G 
Sbjct: 239 QALSCGFVVGKGQ 251


>UniRef50_A7E450 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7E450_SCLS1
          Length = 400

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 84/266 (31%), Positives = 135/266 (50%), Gaps = 23/266 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     L IAG+D SGGAG++AD K  +A   Y  +  TAL AQNTRGV+ ++ I  +FV
Sbjct: 1   MGIGRVLVIAGSDSSGGAGLEADQKVIAAHECYAMTATTALTAQNTRGVEDIHHIPAEFV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
              +D    D+ +D  K    A  + VE VA+ L+R+ ++ +++D VM++ SG  LL   
Sbjct: 61  GKLIDVTIGDMGVDVVKT---ASAETVEVVAKALKRHHVKTLIVDPVMISTSGTQLLPSI 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLD-----APHARTEQEMLEQGRSLLAMGCGAVLM 175
           A+  LR  LLP  +++TPN+PEA  LL          +   ++    + + ++G   VL+
Sbjct: 118 AIRHLRELLLPYTTVLTPNVPEAKLLLSDAGKFVEEPKNLDDLKNIAKEVQSLGPRYVLV 177

Query: 176 KGGHL-------------DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           KGGHL             + E   D L+              ++NTHGTGC++++A+A+ 
Sbjct: 178 KGGHLPLRKDGTVATKEEEKELMVDILYGEGVITEIRTKYQNSRNTHGTGCSMASAIASN 237

Query: 223 RPRHTNWADTVQEAK--SWLSSALAQ 246
             +       V+ A    ++   L +
Sbjct: 238 IAKGIPLVQAVRSACWGHFIEYLLER 263


>UniRef50_UPI0001C31AB2 phosphomethylpyrimidine kinase n=1 Tax=Conexibacter woesei DSM
           14684 RepID=UPI0001C31AB2
          Length = 284

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 102/260 (39%), Positives = 143/260 (55%), Gaps = 9/260 (3%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +    ++IAG+D  GGAGIQADLK F+A G +G + ITAL AQNT GV +V  I P+ + 
Sbjct: 14  RIPAVISIAGSDSGGGAGIQADLKVFAACGVHGMTAITALTAQNTVGVDAVAPIAPEMIV 73

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSPS 120
           AQ+ +V  D+ ID  KIGML     +EAV   L    +   +VLD VM+++SG PLL P 
Sbjct: 74  AQVRAVARDIGIDAVKIGMLGTVVTIEAVVAALGELAEGTPIVLDPVMVSESGAPLLEPE 133

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A   L   LLP+V++ TPNLPEA  +       ++ +  E  R++ A+G   V++ GGH 
Sbjct: 134 ARDALIELLLPRVTVATPNLPEARVIAG-----SDDDAPELARAIHALGPRHVVVTGGHR 188

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +++ D +F  E        R      HG+GCT S+ALAA         D  + AK   
Sbjct: 189 --DKATDVMFDGETTIEIPGERHPDGAAHGSGCTHSSALAAHLALGFAPVDAARAAKVIA 246

Query: 241 SSALAQADTLEVGHGIGPVH 260
           + A+      E+G G GPV 
Sbjct: 247 AQAVHDGLR-EIGRGPGPVD 265


>UniRef50_Q03NL9 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Lactobacillus brevis ATCC 367 RepID=Q03NL9_LACBA
          Length = 264

 Score =  222 bits (566), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 83/252 (32%), Positives = 128/252 (50%), Gaps = 4/252 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N LTIAG+D   G GIQADLKTF  L  +G SV+T++V+     +++   +  + +A QL
Sbjct: 3   NVLTIAGSDSLAGGGIQADLKTFEELHTFGLSVLTSVVSVLPDELKAFQ-LPAEVMATQL 61

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
            SVF  V I   K G+L     +    + L+     +VV+D VM+ K G   ++P  +  
Sbjct: 62  TSVFDQVPIKAVKTGLLGNLTALTLAVKCLRS-SQISVVVDPVMVFKEGPLQVTPEYLTA 120

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L+  LLP  ++ TPNL EA  L         ++M+   R + A+GC  V++KGG  L   
Sbjct: 121 LKETLLPLATITTPNLLEAQQLSGLT-ITNREQMVAAARQIQALGCPNVVIKGGSRLGGS 179

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSA 243
            +PD L   +      AP I+   + G GCT SAA+ A   +     + V  AK ++ +A
Sbjct: 180 VAPDCLLIGDDVTWLEAPIILNAASDGAGCTFSAAITAQLAKGQELLEAVTFAKKFVHAA 239

Query: 244 LAQADTLEVGHG 255
           +     +   +G
Sbjct: 240 ITHGVAISHDYG 251


>UniRef50_D1W4K2 Putative phosphomethylpyrimidine kinase n=2 Tax=Prevotella
           RepID=D1W4K2_9BACT
          Length = 357

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 85/264 (32%), Positives = 145/264 (54%), Gaps = 8/264 (3%)

Query: 1   MK-RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDF 59
           MK R   LTI G+D SGGAGIQAD+K  ++LG Y  SVIT++  QNT G+Q  Y I  D 
Sbjct: 1   MKQRNTILTITGSDGSGGAGIQADIKVITSLGGYAVSVITSITMQNTLGIQRFYDIPADI 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           VA Q++++  D++    K+GM+     +E V   L + Q   ++ D V+ +  GD L+ P
Sbjct: 61  VAEQVEALVDDIKPSVVKVGMVRNVKTLENVVSILAKRQPLKLIYDPVVTSSQGDLLMPP 120

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             + +++++LLP  SL+     +AA LL++P  +T  +++   R LL MGC AVL+  G 
Sbjct: 121 EMIDSVKTKLLPLCSLVILKQNDAAYLLNSP-LKTHDDIVNGMRKLLNMGCRAVLLHSGD 179

Query: 180 LDDEQSPDWLFTREGEQRF-TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
             D  +    + ++G+     +P +   N HG G  L++A+A       ++ + +    +
Sbjct: 180 DHDFIA----WQQDGDIHVEPSPTLWQTNAHGLGSNLTSAIAYFLGETDDFREAISRGNA 235

Query: 239 WLSSALAQADTLEVGHGIGPVHHF 262
           ++   +++   L+ G G   ++ F
Sbjct: 236 YIHQQMSEMGELK-GRGSELLNAF 258


>UniRef50_B0R885 Phosphomethylpyrimidine kinase / thiamin biosynthesis protein thiN
           n=5 Tax=cellular organisms RepID=B0R885_HALS3
          Length = 445

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 110/262 (41%), Positives = 149/262 (56%), Gaps = 6/262 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
              ALTIAG+D  GGAGIQADLKTF A  A+G S ITA+ AQNT GV     + P+ V A
Sbjct: 2   HPVALTIAGSDSGGGAGIQADLKTFEAGDAFGTSAITAVTAQNTHGVTHSDILAPETVRA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+D+V +D  +   K GML +  +V+AVA  L       V +D V++++SGD LL+ S +
Sbjct: 62  QIDAVTTDFDVSAVKTGMLGDAAVVDAVATALAETP-APVTVDPVVVSQSGDRLLTESGI 120

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A +R  LLP+ +L TPN+PEA  L D      E ++     ++  +G  A L+ GGHLD 
Sbjct: 121 AAVRDELLPRATLATPNIPEAELLAD-TEITDETDLRAAAEAVCELGPDATLLTGGHLDG 179

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           +     +F  +    FT PRI T  THG+GCTLSAA+ A           V+     +++
Sbjct: 180 DPVD--VFAGDTTSAFTRPRIETPTTHGSGCTLSAAITARLAHGDALRPAVERGIDAVAA 237

Query: 243 ALAQADTLEVGHGIGPVHHFHA 264
           A+     L VG G GPV H HA
Sbjct: 238 AID--GDLSVGGGDGPVDHRHA 257


>UniRef50_A2SG79 Phosphomethylpyrimidine kinase / thiamine-phosphate
           pyrophosphorylase n=1 Tax=Methylibium petroleiphilum PM1
           RepID=A2SG79_METPP
          Length = 532

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 92/259 (35%), Positives = 130/259 (50%), Gaps = 6/259 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R    +IAGTD  GGAG+ AD +   A G + C V++A+ AQN+  V  + R+ P  + A
Sbjct: 8   RPVVWSIAGTDSGGGAGLSADQRAADAFGVHLCPVVSAVTAQNSLAVTRIERLPPLALEA 67

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ---IQNVVLDTVMLAKSGDPLLSP 119
           QL+++  D+     K G+L   + V  VA  + R +      +V+D V+ A SG     P
Sbjct: 68  QLEALADDLPPQVVKTGLLGGAEHVRRVAHWIDRLRRRQPVALVVDPVLAASSGATFADP 127

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
             +A  R  LLP+ +LITPN  EAAALL  P A T   +  Q  +L   G  AV + GG 
Sbjct: 128 DTLAAYRELLLPRATLITPNRREAAALLGQPEAGT-AGLPAQALALRRRGAQAVCITGGD 186

Query: 180 LD--DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
               D +  DW+ T + +    APRI T + HG+GCT +++ AA        AD +  AK
Sbjct: 187 AADLDGRVLDWMATEQADGWLAAPRIATPHHHGSGCTFASSAAAALALGFVPADALVLAK 246

Query: 238 SWLSSALAQADTLEVGHGI 256
                AL  A     G G 
Sbjct: 247 MATGHALRHAHPAGAGRGP 265


>UniRef50_Q6FDT4 Bifunctional protein n=17 Tax=Moraxellaceae RepID=Q6FDT4_ACIAD
          Length = 259

 Score =  221 bits (564), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 7/247 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R   L  +G DPSGGAG+QAD+++    GA+     TAL  QN++ V        + + A
Sbjct: 2   RPTVLCFSGLDPSGGAGLQADIESIGQSGAHAAIACTALTIQNSQQVFGFEATSKELLLA 61

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q ++V  D+ I   K GML  T+ + A+A+ L+ +     VLD V++A SG  L   + +
Sbjct: 62  QANAVVVDLPIKCVKSGMLGTTENIAALAQFLREHPDYQYVLDPVLVANSGGSLGDQATL 121

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD- 181
                 L+P  ++ITPN  E  AL    +           + L  MG  A+L+KGGH   
Sbjct: 122 VKAFVELIPLATVITPNTVELRALTGLDNIED------ATQKLFDMGAQAILVKGGHEAT 175

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            +   + LF +      +    +    HG+GC+L++ +A       +    VQ A+ WL 
Sbjct: 176 PDHIHNQLFIKGELVAESTCPRLEGEYHGSGCSLASYIAGRLALGDDLKIAVQHAEVWLF 235

Query: 242 SALAQAD 248
             L QA+
Sbjct: 236 DVLKQAE 242


>UniRef50_D0U4N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4N3_9GAMM
          Length = 252

 Score =  219 bits (560), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 67/246 (27%), Positives = 117/246 (47%), Gaps = 9/246 (3%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            L ++G DP GGAGI AD++T +  G     +IT L  QNT+ V+S   ++   +A Q +
Sbjct: 5   VLVLSGLDPCGGAGIAADIETINQFGVTPLPIITTLTVQNTQSVKSTQEVDSKLIAEQFN 64

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
            + +DV     KIG+L+    +E +   L       +VLD ++ + + D LL    +  L
Sbjct: 65  HLKTDVTFSVAKIGLLSSKKQIEVLTNLLSECDDVTIVLDPIVKSTAKDKLLDSQTLEVL 124

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           +++LLP V +ITPN+ E  AL      + EQ+ +E      ++ C  VL+      +++ 
Sbjct: 125 KTKLLPLVDVITPNVDELQALS---PNKNEQQAVE------SLPCEWVLLTTTDSSNDEI 175

Query: 186 PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALA 245
              L+             +  + HG+GCTL++++A L           + A  +    L 
Sbjct: 176 EHRLYHHAELLERYTYTKLPGDYHGSGCTLASSIAGLLALGVETRIACKRALDYTYQTLL 235

Query: 246 QADTLE 251
            A ++ 
Sbjct: 236 NAKSIG 241


>UniRef50_C5RC57 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=1
           Tax=Weissella paramesenteroides ATCC 33313
           RepID=C5RC57_WEIPA
          Length = 268

 Score =  219 bits (559), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 72/261 (27%), Positives = 128/261 (49%), Gaps = 4/261 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     +TIAG+D   G G+QADL TF+  G +G S IT++V  N      ++ +    +
Sbjct: 1   MVVGKIITIAGSDTLSGGGVQADLATFNEYGLFGLSAITSIVTVNQYDF-DIHEVPISVL 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRY-QIQNVVLDTVMLAKSGDPLLSP 119
           A QL S+     I   K+G+L     ++ V++ +++Y     +V+D VM  K  D + + 
Sbjct: 60  AKQLTSLGELSDIKGIKVGLLPSVAHIDLVSQFIKQYVGRVPIVIDPVMAFKETDSVNAS 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG- 178
                ++ +LLP  +++TPNL EA  L       +E ++L     L  +G   V++KGG 
Sbjct: 120 ELSTAIKQKLLPLATVVTPNLIEAELLTQQA-IHSEADLLTVAEMLHKIGPKTVVVKGGV 178

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            LD + + D + + + ++     +I     +G GCT SAA+A+   ++      + +AK 
Sbjct: 179 RLDGDMASDAVISEDTKKVIKLSKIERPFNNGAGCTFSAAIASQIAQNVPVLMAIDDAKD 238

Query: 239 WLSSALAQADTLEVGHGIGPV 259
           ++   +     L     +G V
Sbjct: 239 FVHHGILHGVNLNDDFKVGNV 259


>UniRef50_C0X709 Possible phosphomethylpyrimidine kinase n=22 Tax=Enterococcus
           faecalis RepID=C0X709_ENTFA
          Length = 278

 Score =  219 bits (558), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 70/256 (27%), Positives = 123/256 (48%), Gaps = 5/256 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M +I  LTI G+DP  G GIQ DLKTF     +G S +T L A   +    ++ +E   V
Sbjct: 8   MTKI-ILTIGGSDPFSGGGIQTDLKTFENHQVFGLSTLTCL-ATAPKNHFQIHDLETSLV 65

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL S+ +   +D  KIG++   + +  +   L+++    VVLD V+  K    +    
Sbjct: 66  KEQLASIPAG-SLDGIKIGLIHSEESMLQIVTFLKKHAGLPVVLDPVLAFKETTSVYEKR 124

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
            +  L  +L P  ++ITPNL EA  L+      T +E+ +    L ++G   V++KGG+ 
Sbjct: 125 YMQLLIEKLFPFATIITPNLKEAELLIGRK-LTTVEEVQQAAEELNSLGAATVVIKGGNR 183

Query: 181 -DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              +++ D+ +  +   +    ++M     G GC+ ++A+ A   +     + V  AK++
Sbjct: 184 WLGQEARDFFYDGQQHIQLVKEKVMAHTIDGAGCSFASAIGANLVKGYPLIEAVDLAKTY 243

Query: 240 LSSALAQADTLEVGHG 255
           +  A+     L    G
Sbjct: 244 VHEAIVSGVQLNAAFG 259


>UniRef50_O28075 Hydroxymethylpyrimidine phosphate kinase (ThiD) n=1
           Tax=Archaeoglobus fulgidus RepID=O28075_ARCFU
          Length = 243

 Score =  218 bits (557), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 81/251 (32%), Positives = 123/251 (49%), Gaps = 16/251 (6%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTI+G DPSGGAG+ AD+KT  A+G Y  SVIT+L  QNT GV++   +E + +
Sbjct: 1   MK--TILTISGLDPSGGAGVSADIKTAKAIGLYPASVITSLTVQNTCGVKAAIPVEAEVI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL +V  D++ID  KIG++   +I + +A  L        VLD V+ A +G  +    
Sbjct: 59  REQLRAVIEDMKIDCIKIGLITSVEIAKVLAAELVPLNAPK-VLDPVIFAGAGGKIGDEE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A       +L  V ++TPNL EA  LL      + +E  E    +       V++ GG L
Sbjct: 118 AY----KMILKHVDIVTPNLTEAITLL-----ESTKEARELALEMNKKYGCDVVITGGEL 168

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
             +   D +         +A      N HGTGC  S ALA       +  + V++A+ ++
Sbjct: 169 GGK---DVVCEAGRTYTVSAE-FSPVNIHGTGCVYSTALACYLGLGNSLENAVRKARIFV 224

Query: 241 SSALAQADTLE 251
             ++ +A    
Sbjct: 225 LESVKKALRPG 235


>UniRef50_Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
           C18B5.05c n=1 Tax=Schizosaccharomyces pombe
           RepID=YJK5_SCHPO
          Length = 327

 Score =  218 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 72/264 (27%), Positives = 131/264 (49%), Gaps = 19/264 (7%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
                LTIAG+D SG AGIQADLK  +A   YG SV+TAL  QN+ G+  +Y + P  + 
Sbjct: 12  NHPTCLTIAGSDCSGAAGIQADLKVMTAHQVYGMSVLTALTCQNSHGITGIYPLHPSLIQ 71

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+D+  SD++    KIGML +   +  +++ L +Y+I +VV+D+V+++  G+ +     
Sbjct: 72  RQIDACLSDIQCRVVKIGMLPDPKSIPVISQALTKYKITDVVMDSVIISSMGNVMCETPT 131

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDA------PHARTEQEMLEQGRSLLAMGCGAVLM 175
           +      L P + +   N+ EA  L++       P  ++  ++      +  +G   V++
Sbjct: 132 IPATIQHLFPHLLVYASNVMEAFILVEKTLKKSPPPLKSFPDIQNLMSIIHRLGPKFVVL 191

Query: 176 KGGHLDDEQ-------------SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAAL 222
           +G H+  ++             + D ++  +    F  P   TK+ HG  C+L+AA+A+ 
Sbjct: 192 RGHHVAFDKNMMITEKPDSKSWTADLIYDGKEFYIFEKPYNTTKSIHGESCSLTAAIASN 251

Query: 223 RPRHTNWADTVQEAKSWLSSALAQ 246
              +      + EA   +  A+ +
Sbjct: 252 LACNIPPLQAIHEALYSIEWAIQR 275


>UniRef50_D0L0X1 Phosphomethylpyrimidine kinase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0L0X1_HALNC
          Length = 285

 Score =  218 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 83/253 (32%), Positives = 131/253 (51%), Gaps = 3/253 (1%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L  +G DPSGGAG+QAD++   + G +  +VITAL  Q+T  V+     +P  V  Q
Sbjct: 9   PVVLVFSGHDPSGGAGVQADIEAIISQGVHPATVITALTVQDTVDVKRFVPTDPSLVIEQ 68

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
             +V  D+ +   KIGM+    +VE +   L+ Y    VVLD V++A  G  L +     
Sbjct: 69  ARAVLEDMPVQCIKIGMIGSVALVEVIHSILKDYPDIPVVLDPVLIAGGGGALANEDVAK 128

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            + + LLP  +++TPN  E+ AL+   H     ++  +G+ LL MG   VL+KGG     
Sbjct: 129 AMINLLLPLTTILTPNAYESRALVKVAHVP-ANDLDARGQVLLEMGPEYVLLKGGDEQST 187

Query: 184 QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR--HTNWADTVQEAKSWLS 241
           +  +WL+TR    R      +    HG+GCTL++A+A L  +    ++ + + EA+ + S
Sbjct: 188 EVENWLYTRHQPPRKFTYERLPGEFHGSGCTLASAIAGLIAQATDADYVNAIHEAQEYTS 247

Query: 242 SALAQADTLEVGH 254
            AL  A  +  G 
Sbjct: 248 HALFHAAQIGRGQ 260


>UniRef50_B7G3W4 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G3W4_PHATR
          Length = 580

 Score =  218 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 84/292 (28%), Positives = 134/292 (45%), Gaps = 62/292 (21%)

Query: 19  GIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKI 78
           GIQADL    + G +GCS IT L AQN+ GV  V+   PDF+ AQL+++  D+     KI
Sbjct: 52  GIQADLHAIHSFGCHGCSAITCLTAQNSVGVIGVHAPPPDFLRAQLETLLEDLPPQAIKI 111

Query: 79  GMLAETDIVEAVAERLQRYQI----QNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVS 134
           GML   ++   V   L++ +       VVLD VM+  SG  L+   A   +   + P + 
Sbjct: 112 GMLGTKELAIEVGAFLKKLKALDRKVWVVLDPVMITTSGHRLIEEDAQEAMVKHVFPHID 171

Query: 135 LITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL--DDEQSPDW---- 188
           ++TPN  EA ALL+     T  ++ E  + L+A+G  +VL+KGGH   +  ++ +     
Sbjct: 172 VLTPNKFEAEALLNRT-LETISDVEEGAKDLIALGAPSVLIKGGHTLYEGGKASNHIAYA 230

Query: 189 ----------------LFTREGEQRFTAPRIMTKNTHGTGCTL----------------- 215
                           L   +      +PR  T++THGTGCTL                 
Sbjct: 231 QDYFLSSVQRNTGEPRLCDGDLGVWLRSPRYETEHTHGTGCTLSASLAASLALGEQERQK 290

Query: 216 --------SAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
                   ++A+        +  D    AK+++++ +     +++G G GPV
Sbjct: 291 PDGKRRGATSAI--------DTVDACCLAKAYVTAGIFHG--IQLGQGPGPV 332


>UniRef50_B9E8N3 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=56
           Tax=Bacilli RepID=B9E8N3_MACCJ
          Length = 276

 Score =  217 bits (553), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 5/263 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGV-QSVYRIEPDF 59
           M     LTIAG+D S GAG+QADLKTF     YG   +TA+VA +      +V  +  + 
Sbjct: 1   MSLKKILTIAGSDTSAGAGMQADLKTFQEYNTYGMVALTAVVAMDPETWAHNVTPLPIEL 60

Query: 60  VAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSP 119
           +  Q+ +  S +  D  K GML   +I++  A+  +       V+D VM+ K  D +L+P
Sbjct: 61  LDKQIKTALS-IGPDAIKTGMLGTEEIIQRAAKAFEDSDAAYFVVDPVMVCKGEDEVLNP 119

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
                +   LLP  +++TPNL EA  L       T ++M E    +   G   V++KGG 
Sbjct: 120 GNTDAMIKYLLPLATIVTPNLFEAGQLSGLGKLTTMEQMKEAAEIIHQRGAKHVIIKGGK 179

Query: 180 -LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            L+ +++ D  +  +     T  +  +   HG GCT +AA  A      +  + V  AK 
Sbjct: 180 ALESDEALDLYYDGDTYTLLTTDKFQSSYNHGAGCTFAAATTANLALGKSPREAVIAAKG 239

Query: 239 WLSSALAQADTLEVGHGIGPVHH 261
           +++SA+      ++   +GPV H
Sbjct: 240 FVASAIKHG--WKMNEFVGPVQH 260


>UniRef50_A7ZEN6 Phosphomethylpyrimidine kinase n=1 Tax=Campylobacter concisus 13826
           RepID=A7ZEN6_CAMC1
          Length = 254

 Score =  217 bits (553), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 83/255 (32%), Positives = 133/255 (52%), Gaps = 21/255 (8%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
            + N L +AG+D  GGAG+QAD+K+  A   +  SVITA+ AQNT GV SV  +  + V 
Sbjct: 6   SKKNVLIVAGSDSVGGAGVQADIKSCEAFSCFSASVITAVTAQNTNGVSSVLAMPANMVK 65

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQ--NVVLDTVMLAKSGDPLLSP 119
           AQ + V +++ ID  K+GML   +I+  V+  L+  + +   VV+D V +AKSG  LL  
Sbjct: 66  AQFEMVLAELDIDAVKVGMLFNEEIIAVVSAFLKELRAKNVPVVIDPVCVAKSGAKLLED 125

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH 179
            A+  L+  LL   S+ TPN+ EA  L               G     + C  VL +   
Sbjct: 126 GAIEALKE-LLNLASVATPNVDEARIL---------------GIDFANLPCDMVLKRT-- 167

Query: 180 LDDEQSPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
             DE   D L+ + G+  +F+      +  HG GC+ S++LAA+  + ++    ++ AK 
Sbjct: 168 KVDEICEDTLYLKNGDAMKFSEELFEPRVMHGAGCSFSSSLAAILAQQSDLVSAIKMAKK 227

Query: 239 WLSSALAQADTLEVG 253
           ++++ +  A   + G
Sbjct: 228 FVANGIKNAHKSKFG 242


>UniRef50_B5YA99 Phosphomethylpyrimidine kinase n=2 Tax=Dictyoglomus
           RepID=B5YA99_DICT6
          Length = 263

 Score =  217 bits (553), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 76/255 (29%), Positives = 121/255 (47%), Gaps = 5/255 (1%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             L IAG DPSGGAGI  D K    LG Y   + T L  QNT+ V   Y I P +     
Sbjct: 8   KILVIAGFDPSGGAGILLDTKIIHYLGGYAFCIPTCLTVQNTQKVYKTYEINPKYFLKTF 67

Query: 65  DSVFSDV-RIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           +++  DV   D  KIG L    I++ +   +  Y+++N++LD V+    G PLL   A +
Sbjct: 68  EALIKDVDYFDGVKIGALYSKKIIDLIINLIITYELKNIILDPVINPTKGKPLLKKDAFS 127

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGC-GAVLMKGGHLD- 181
           +L  +L+   S+ITPN+PEA  L      ++  +M      +        +++KGGHL  
Sbjct: 128 SLL-QLISLCSVITPNIPEAEFLSGIK-IKSLDDMEFSLLKIRDKFNIKNIILKGGHLAI 185

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
             +  D L+T +    F    +  K+ HGTGC  S+ L     ++ +      E ++  +
Sbjct: 186 GNEVYDLLYTEDKIISFKKEYLKNKHIHGTGCLFSSILTFFLAQNLSIEKAFYETENNFN 245

Query: 242 SALAQADTLEVGHGI 256
             + +A  +  G  +
Sbjct: 246 KFIKRAIKISKGQYV 260


>UniRef50_A4XBK7 Phosphomethylpyrimidine kinase n=4 Tax=Actinomycetales
           RepID=A4XBK7_SALTO
          Length = 262

 Score =  217 bits (553), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 110/263 (41%), Positives = 147/263 (55%), Gaps = 6/263 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M     LTIAG+D  GGAGIQADLK F+AL AYG SV+TA+ AQNTRGV +V  + P  V
Sbjct: 1   MTPSTVLTIAGSDSGGGAGIQADLKVFAALEAYGTSVVTAVTAQNTRGVDAVLPLPPQTV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             QL+SV +D  +   K GML    + E VA   +  ++ ++V+D V++A SG  L + +
Sbjct: 61  TDQLESVLADFSVRAVKTGMLGSPAVAEVVAVAARDGRLPHLVVDPVLVATSGHRLGAVA 120

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           AV     RLLP   + TPN  EAAAL       T +EM+    +L A G   V++ GG  
Sbjct: 121 AV----ERLLPFAQVATPNRAEAAALTGGR-VDTVEEMVAAATALTAGGPEYVVVTGGDG 175

Query: 181 D-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           D  E + D L    G     A R+ T++ HGTGC+ SAA+A    R       V  AK +
Sbjct: 176 DAGEPAVDVLHGEGGTTLLRASRVPTRHNHGTGCSFSAAVAVRLARGDAVPVAVAAAKEY 235

Query: 240 LSSALAQADTLEVGHGIGPVHHF 262
           ++ AL  A   E+G G GP+ HF
Sbjct: 236 VTRALIGARDWELGAGPGPLDHF 258


>UniRef50_B2UMB7 Phosphomethylpyrimidine kinase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UMB7_AKKM8
          Length = 257

 Score =  216 bits (552), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 88/246 (35%), Positives = 126/246 (51%), Gaps = 4/246 (1%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           +TIAG+D S GAG+QADLK   A+GA+  + +T +V++    V+ +  ++P  VA Q+  
Sbjct: 2   MTIAGSDCSAGAGLQADLKAAHAMGAFALTAVTCVVSEAPGTVRGIQEVDPSLVADQVRI 61

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
                 +   K GML    IV AV   L       VV+D VM+A +GD L+   AVA   
Sbjct: 62  NLEHFPVRAVKTGMLYSPAIVRAVHGVL-DGADIPVVVDPVMIATAGDRLMREEAVAVYE 120

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LLP  +L+TPNL EAA LL +       E+ E    L       VL+KGGHL+ +   
Sbjct: 121 ELLLPGAALLTPNLDEAAVLLRSSVNPGRDELPEAAARLAVRYGCPVLLKGGHLEGD-CR 179

Query: 187 DWLFTREGEQR--FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSAL 244
           D L   +G     +  PR+   +THGTGC+LSAA+AA           V+    +++SA+
Sbjct: 180 DVLSGPDGCLLGQWERPRVQDVSTHGTGCSLSAAVAARLAAGDGLVAAVERGLEFIASAI 239

Query: 245 AQADTL 250
                 
Sbjct: 240 RNHLRW 245


>UniRef50_Q756M8 AER226Wp n=1 Tax=Eremothecium gossypii RepID=Q756M8_ASHGO
          Length = 316

 Score =  216 bits (551), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 93/269 (34%), Positives = 134/269 (49%), Gaps = 11/269 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LT+AG+D SGGAGI+AD+KT +  G Y  + I+A+ AQ  R V +V       +AA L
Sbjct: 24  TVLTVAGSDSSGGAGIEADIKTITMHGCYAMTCISAITAQTPRAVDAVRATPAPLLAAVL 83

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQ-IQNVVLDTVMLAKSGDPLLSPSAVA 123
             +F D+ +D  K GML     V+ +   L+ ++    +V+D VM A SG PL   +  A
Sbjct: 84  RGLFRDMAVDAIKTGML-TPAAVDCLLAALRDHRFAGPLVVDPVMAASSGSPLTDLAGPA 142

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL--D 181
                    +  +TPN+PEA  LL A    +   ++   ++L      AVL+KGGH    
Sbjct: 143 ARALLRRAAL--VTPNVPEACRLLAAQPPASPDGLVSLAQALARDLSTAVLLKGGHCPYP 200

Query: 182 DEQSPDWLF---TREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKS 238
            +   D L       G   F A R+ T +THGTGCTL+AA+AA   R  +  + V     
Sbjct: 201 PDAVLDVLVDPADPAGPVTFCARRLSTPHTHGTGCTLAAAIAANLSRAMSLREAVYRGII 260

Query: 239 WLSSALAQADTLEVGH--GIGPVHHFHAW 265
           ++  A+A      V      GPVHH +A 
Sbjct: 261 FVHHAIALQPERSVCALPENGPVHHAYAL 289


>UniRef50_C3X5F6 Phosphomethylpyrimidine kinase n=2 Tax=Oxalobacter formigenes
           RepID=C3X5F6_OXAFO
          Length = 272

 Score =  215 bits (549), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 79/262 (30%), Positives = 132/262 (50%), Gaps = 15/262 (5%)

Query: 1   MK---RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEP 57
           MK   R   L  +G DPSGGAGI AD++   A+GA+   V+TAL  Q+   V +V  ++ 
Sbjct: 10  MKEKSRHCVLVFSGLDPSGGAGISADIEAIGAVGAHALPVVTALTVQDNDRVYAVNPVDA 69

Query: 58  DFVAAQLDSVFSDVRIDTTKIGMLAETDIV----EAVAERLQRYQIQNVVLDTVMLAKSG 113
             ++ Q   +   + +   K+G++   D      E ++E  ++     VVLDTV+ +  G
Sbjct: 70  AIISRQAQVLAGKIPVSAVKVGIVGNRDNAVAIGEVISELRRKQPGLPVVLDTVLGSGHG 129

Query: 114 DPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAV 173
             L +        S L+   +L+TPNLPEA  L         ++  +Q   L+A G   V
Sbjct: 130 FAL-ADGTPEYALSPLIGMATLVTPNLPEAKRLCPL-----AKDTRKQAEYLMAQGAANV 183

Query: 174 LMKGGHLDD-EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADT 232
           L+KGGH +D +   +  F  +G +++   R +    HGTGCTL++A+AA   +       
Sbjct: 184 LIKGGHGEDADSVFNQWFGADGMKQWK-WRRLPGEFHGTGCTLASAIAAYLAQGLLMEKA 242

Query: 233 VQEAKSWLSSALAQADTLEVGH 254
           +++ + W  +AL +A ++  G 
Sbjct: 243 LEKGQVWCQAALEKAFSIAKGQ 264


>UniRef50_UPI000050F6FE phosphomethylpyrimidine kinase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F6FE
          Length = 274

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 77/260 (29%), Positives = 127/260 (48%), Gaps = 8/260 (3%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNT-RGVQS-VYRIEPDFVAA 62
             LTIAG+D SGGAG++ADLK F   GA+G + +T +V  +   G    +  I+P+ V  
Sbjct: 4   KVLTIAGSDVSGGAGLEADLKMFEEYGAFGTAAVTCIVTFDPNDGFSHVIEFIDPEVVTR 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           QL+S  +  + D  K GML   +    +A++L+       V D V++ K    ++     
Sbjct: 64  QLESTLAVHKFDAIKSGMLGSVENALVLAQKLKT-NELPYVFDPVLVCKGAGTMV--DLK 120

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLD 181
                 L+P  ++ITPNL EAA L       + + M+E  + + A G   V++KGG  L 
Sbjct: 121 DLFVDNLVPLATVITPNLEEAATLAGLEPIDSVEGMVEAAKIIHAQGAKNVVVKGGARLA 180

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            E + D +F  E      + ++  K  +G GC+ ++++AA         D V  AK  ++
Sbjct: 181 GEDAIDIVFDGESITTLRSRKVNEKLVNGAGCSFASSIAAGITTGLIIQDAVVSAKEKVA 240

Query: 242 SALAQADTLEVGHGIGPVHH 261
             +A    L+   G+  + H
Sbjct: 241 HGIANC--LDNATGVASLFH 258


>UniRef50_C6HXY3 Phosphomethylpyrimidine kinase n=1 Tax=Leptospirillum
           ferrodiazotrophum RepID=C6HXY3_9BACT
          Length = 270

 Score =  215 bits (548), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 93/242 (38%), Positives = 130/242 (53%), Gaps = 6/242 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK   AL++AG DPSGGAG+  DL+ FSALG  G  V T L  QN +GV     + P+ +
Sbjct: 1   MK-GYALSVAGLDPSGGAGLYQDLRVFSALGIRGQGVPTVLTVQNLQGVGRTEPLSPELL 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNV-VLDTVMLAKSGDPLLSP 119
           +A L++V  +      KIG++A + +VE +A+ L       V +LD V L  +G  +L+P
Sbjct: 60  SAMLEAVVGEGPPRAVKIGLMASS-LVEELADFLDGLPKDVVRILDPVFLFGTGGSVLTP 118

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLL-AMGCGAVLMKGG 178
            A   L   L P+V L+TPNLPEA  L         ++++   R L    G  AVL+KGG
Sbjct: 119 PAYRDLARSLFPRVDLVTPNLPEALELGGEIPGSRPEDLVLMARRLHDQYGVRAVLLKGG 178

Query: 179 HLDDEQS-PDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHT-NWADTVQEA 236
           H + E+   D  +T  GE+ F+ P       HG GCTLS+ +AAL  R   +  D V  A
Sbjct: 179 HRNGEEPRTDLFWTPSGERFFSHPFRRLPGVHGGGCTLSSLVAALLVRGESSLIDAVARA 238

Query: 237 KS 238
             
Sbjct: 239 LE 240


>UniRef50_A2BMS2 Multidomain protein n=3 Tax=Desulfurococcales RepID=A2BMS2_HYPBU
          Length = 475

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 93/263 (35%), Positives = 134/263 (50%), Gaps = 7/263 (2%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
             A+T+AG DPSGGAGI ADLK F+A+G +G  V+  +  Q+TRGV+ V+ +    V  Q
Sbjct: 19  PVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQ 78

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L +V  D R+   K G+L   + VEA+A  L+  +   +V+D V  A +G  L S  A  
Sbjct: 79  LQAVLEDYRVGAVKTGVLGSRENVEAIARLLRG-RDIALVVDPVYRASAGQLLNSDDAFK 137

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLA-MGCGAVLMKGGHLDD 182
            +   L P  SL+ PN+PEA  +      R+ ++     R L+   G  A L+KGGHL  
Sbjct: 138 AIVEELFPLASLVAPNVPEAERITGTR-IRSIEDAKRAARILVEDYGARAALIKGGHLPG 196

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
           E   D L+  +    F   R    + HGTGCT +AALAA   +  +  + V  A+  +  
Sbjct: 197 EP-VDVLYYEDVFWEFRGERRSGCS-HGTGCTFTAALAAGLAKGLDLVEAVVRARKLVEE 254

Query: 243 ALAQADTLEVGHGIGPVHHFHAW 265
           A+       VG G  PV+     
Sbjct: 255 AIEYGFR--VGRGDCPVNPLAGL 275


>UniRef50_A7GXD3 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=A7GXD3_CAMC5
          Length = 244

 Score =  213 bits (544), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 76/262 (29%), Positives = 127/262 (48%), Gaps = 23/262 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK  N L IAG+D +GGAG QAD+KT  A G Y  + IT  V +NT+    +  +    V
Sbjct: 1   MK--NILIIAGSDSAGGAGAQADIKTCEAFGCYSATAITVFVCENTQVTYDISSVPASCV 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
            +Q+  +  +++ID  KIGML +   ++ V + L ++    +V+D V ++KS   L+   
Sbjct: 59  DSQIRGITEELKIDAVKIGMLFDVQTIKVVEKWLPKFN-VPIVIDPVCISKSNVKLIKDD 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  LR  +L   ++ TPN  EA AL     +                    V++K  H+
Sbjct: 118 AIDALRG-ILKFATIATPNRYEAQALFHNDFSSLV---------------CDVIVKK-HV 160

Query: 181 DDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
            + +S D L  ++G Q  F          HG GCT S A+A    +  +  ++V +AK++
Sbjct: 161 VNGESIDTLHKKDGSQLNFATALADPFIMHGAGCTFSTAIACCLAQGLSLEESVTKAKNY 220

Query: 240 LSSALAQADTLEVGHGIGPVHH 261
           +  A+      + G  +  ++H
Sbjct: 221 VYQAIKTGLETKFGKTL--LNH 240


>UniRef50_B0TDW0 Phosphomethylpyrimidine kinase n=1 Tax=Heliobacterium modesticaldum
           Ice1 RepID=B0TDW0_HELMI
          Length = 290

 Score =  213 bits (543), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 94/284 (33%), Positives = 135/284 (47%), Gaps = 28/284 (9%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    +TIAG+DPSGGAGIQADLK  +  G YG + +TAL  Q + GV  ++ +   +V
Sbjct: 1   MKLPKVVTIAGSDPSGGAGIQADLKVLAQFGVYGGAAVTALTRQTSAGVLGLFPLPAAWV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIV----EAVAERLQRYQI----------------- 99
             Q+  V  D+R    K GML +  ++          LQ Y+                  
Sbjct: 61  LEQISDVLWDLRPPVVKTGMLQQPAVISGLGRLWGAYLQEYRDTAAQVLPPASSTTPAPT 120

Query: 100 -QNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEM 158
              +V+D V+ + +G  L+    +A  R  LLP  +++TPN+PEA AL      R   +M
Sbjct: 121 LPILVVDPVLSSGAGVSLVDGGGLAAFREDLLPVTTVLTPNVPEAEALTGMA-IRDSGDM 179

Query: 159 LEQGRSLLAMGCGAVLMKGGHL---DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTL 215
           +     LL  G   VL+KGGHL   + ++  D L +RE  +     R+   + HGTGC+L
Sbjct: 180 IGAAERLLQFGPQWVLLKGGHLPEWEGDRIADLLISREERRWLWGQRVPRADLHGTGCSL 239

Query: 216 SAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           ++ALAA              A  WL   +     L VG G G V
Sbjct: 240 ASALAACLALGLPVPVAAARAVEWLRQRI--GSPLFVGQGRGVV 281


>UniRef50_B9CXT9 Phosphomethylpyrimidine kinase n=2 Tax=Campylobacter
           RepID=B9CXT9_WOLRE
          Length = 245

 Score =  212 bits (540), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 77/254 (30%), Positives = 126/254 (49%), Gaps = 21/254 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK+   L IAG+  +GGAG+QAD+K  +  G Y  + +TAL A+NT  ++++  ++P F+
Sbjct: 1   MKK--ILIIAGSCSNGGAGLQADIKACAHFGCYSATAVTALTAENTDKIKNIVSLDPSFI 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A QL  + ++   D  KIGML    I++ V   L++     VVLD V ++K G  L+  S
Sbjct: 59  ADQLGMLAAEFSFDAVKIGMLFNEPIMDVVQSFLEKNS-APVVLDPVCVSKMGHKLIKDS 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
           A+  L+  L+   ++ TPNL EA  L                          V++K  H+
Sbjct: 118 AIERLKE-LMKFAAVTTPNLREADVLFGDDFTNL---------------PCDVIVKK-HI 160

Query: 181 DDEQSPDWLFTREGEQR-FTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
              +S D L+ ++G  + F  P        G GCT S++LA L  R  +    +Q+ K +
Sbjct: 161 VVGKSIDTLYRKDGSVQNFETPLADPLVIIGAGCTFSSSLACLLARGESLESAIQQGKEY 220

Query: 240 LSSALAQADTLEVG 253
           + +A+       +G
Sbjct: 221 IYNAIITGIDTNLG 234


>UniRef50_B0TY65 Thiamine-phosphate pyrophosphorylase/thiamine-phosphate
           pyrophosphorylase n=1 Tax=Francisella philomiragia
           subsp. philomiragia ATCC 25017 RepID=B0TY65_FRAP2
          Length = 485

 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 60/233 (25%), Positives = 118/233 (50%), Gaps = 2/233 (0%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIG 79
           IQAD+KT + +G + C++I+ + AQN+  + ++ ++       Q+ ++  + +I   K  
Sbjct: 19  IQADIKTANNIGVHACTIISCVTAQNSTNILNIEKVSKGIFKEQIQAISKEFKIKVIKTS 78

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           +L+ T+ ++ V + L   +    + D VM++ +G  L+    V   + +L P  +++ PN
Sbjct: 79  VLSSTEQIDIVVDLLNDLKDVFYICDPVMVSTTGYSLVDYRLVEYSKQKLYPLANILVPN 138

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP-DWLFTREGEQRF 198
           L EA  LLD   +   +             C +VL+KGGH  D+    D  +T E     
Sbjct: 139 LDEAKMLLDEHDSPNVEIAEIAKAIQEKYNCKSVLLKGGHDSDKNISLDCYYTPEVNYTL 198

Query: 199 TAPRIM-TKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTL 250
           T+ R    +   GTGCT ++A+A+      +  +++  AKS++S+A+  +  +
Sbjct: 199 TSKRYKLDEKVRGTGCTFASAIASFLTLGFDVNNSIILAKSYISNAIKSSQKI 251


>UniRef50_C6V659 Phosphomethylpyrimidine kinase n=2 Tax=Neorickettsia
           RepID=C6V659_NEORI
          Length = 254

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 75/250 (30%), Positives = 120/250 (48%), Gaps = 4/250 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K      +AG+D  GGAG+QADL+  + LG    +V+T + AQ+ +GV ++  +  + V+
Sbjct: 3   KIPEICIVAGSDSIGGAGLQADLRIAALLGCSASNVVTCITAQDLKGVHAIQYLSGEIVS 62

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL    S  +    KIGML  ++I  AV + L+      +VLD V+++ S   L    A
Sbjct: 63  KQLICALSR-KPKAIKIGMLGNSEIALAVYDVLKD-TGIPIVLDPVLISTSNSKLADEGA 120

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
           V  L  +LL    L+TPNL EA+ L         +        +  +G   VL+KG H+ 
Sbjct: 121 VQVLLKKLLSISHLVTPNLFEASTLSGNK-VFDAESAKIAALRIFELGAKNVLVKGIHIK 179

Query: 182 DEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           + +  D L ++ G    F    I    THG+GC LS A+A       +  +++  A   L
Sbjct: 180 EGKIMDLLISQGGATMEFQNEVIRINITHGSGCRLSTAIACHMSMGKSLRESIHFASDLL 239

Query: 241 SSALAQADTL 250
            + + +   L
Sbjct: 240 RNEIIRMGVL 249


>UniRef50_UPI000178943A phosphomethylpyrimidine kinase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI000178943A
          Length = 335

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 99/323 (30%), Positives = 141/323 (43%), Gaps = 63/323 (19%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           +   ALTIAG+D  GGAGIQADLKTF  LG YG S ITA+  QNT GV  VY + P+  A
Sbjct: 5   RIPRALTIAGSDSGGGAGIQADLKTFQELGVYGMSAITAITVQNTMGVHGVYPLPPEATA 64

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            Q+++V SD+ +D  K GML   +I+  VA+R++ +    VV+D VM+AK G  LL   A
Sbjct: 65  EQIEAVGSDLGVDALKTGMLFNAEIIRLVADRIRAFGWGKVVVDPVMIAKGGAELLQSEA 124

Query: 122 VATLRSRL----------LPQVSLI------TPN-LPEAAA------------------- 145
           V  LR  L          +P+  ++      T N   EAA                    
Sbjct: 125 VQALREDLLPLALIVTPNIPEAEVLAGMRIRTMNDRNEAARRIHDLGPRIVVIKGGHDEG 184

Query: 146 LLDAPHARTEQE----MLEQGRSLLAM-------GCGAVLMKGGHLDDEQ---------- 184
           +L        +      +        M       G  +  M  G     +          
Sbjct: 185 MLGNGEGTDHERGREPAIAADMQQEEMPQSDRTHGQTSTAMPAGEYSGGRSLFSNDDGNP 244

Query: 185 ----SPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
                 D ++           RI T +THGTGCT SAA+ A   +  +  D +Q  + ++
Sbjct: 245 ESPPVIDLVYDGMAFTELYGKRIHTVHTHGTGCTFSAAITAGLAQGLSAYDAIQSGRLFI 304

Query: 241 SSALAQADTLEVGHGIGPVHHFH 263
            +A+     L +G G GP +H+ 
Sbjct: 305 QAAIEDG--LNLGQGQGPTNHWA 325


>UniRef50_C7M9W8 Phosphomethylpyrimidine kinase n=1 Tax=Brachybacterium faecium DSM
           4810 RepID=C7M9W8_BRAFD
          Length = 291

 Score =  210 bits (536), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 97/285 (34%), Positives = 143/285 (50%), Gaps = 23/285 (8%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M+    LTIA ++  G  G+QADLKTF+ALGAYG S ++ +       V   Y +  + V
Sbjct: 1   MRPPVVLTIAASESDGAGGLQADLKTFTALGAYGASAVSMIATITAHEVHGTYPLPAEVV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQI--QNVVLDTVMLAKSGDPLLS 118
             Q+D+V  D+R+D TKIG L    +V+AVA  ++ ++     +VLD VM++  G PL+S
Sbjct: 61  RGQIDAVAGDLRLDATKIGALGSAAVVDAVAAAVRAHRDRLGRIVLDPVMVSAHGAPLIS 120

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG 178
                 LR +LLP V ++TP + EAA LL  P A + +E+ EQ  +L A G  +VL+ G 
Sbjct: 121 AEGAKALREQLLPLVDVLTPTMAEAAQLLGRPLATSIEEIREQALALQAAGPRSVLVTGR 180

Query: 179 HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPR------------- 225
            L+ E   D L    G     A R+  +   G G TLSAA+AA   R             
Sbjct: 181 LLEGEDVVDVLVHEGGTDLLRAERVPGRRVRGAGATLSAAIAAQLARIAEFDRAGELGEI 240

Query: 226 -----HTNWADTVQEAKSWLSSALAQADTLEVGH---GIGPVHHF 262
                  +    V  A+ +++SA        +     G GP++H 
Sbjct: 241 GEAGSEDDMVTIVASAREFVASATDNVQDWRLSRRSGGHGPLNHL 285


>UniRef50_Q5QUC9 Thiamine monophosphate synthase n=1 Tax=Idiomarina loihiensis
           RepID=Q5QUC9_IDILO
          Length = 504

 Score =  209 bits (534), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 85/268 (31%), Positives = 132/268 (49%), Gaps = 10/268 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           M      TIAG+D  GGAGIQADL TF +L  +GCSVI+ + AQN+     ++ +  D V
Sbjct: 1   MSIPVVWTIAGSDSGGGAGIQADLHTFRSLNVHGCSVISTITAQNSVATTGLFPLAADAV 60

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQR----YQIQNVVLDTVMLAKSGDPL 116
             QL+ +  D+     KIG+L+    ++ VA+ L++         VV D V+++   D L
Sbjct: 61  RQQLECLQQDMPPAAIKIGLLSNVQQLQCVADFLKQWSDPLPQPFVVWDPVVVSTQQDRL 120

Query: 117 LSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMK 176
                     + L P V ++TPNL E + L        E  M      L   G   +L+ 
Sbjct: 121 --SELKPQHCAELFPLVDIMTPNLDELSWLSGL-EVTDEDSMYRAAEQLFQAGLSRILVT 177

Query: 177 GGHLD-DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQE 235
           G      ++  D+  + +G  ++   ++ TK++HGTGCTLS+A+AA         D +  
Sbjct: 178 GTDFGRADEISDYYLSSDGHTQYIQQKLRTKHSHGTGCTLSSAIAAALAHDYPLEDAITV 237

Query: 236 AKSWLSSALAQADTLEVGHGIGPVHHFH 263
           A +++   L +A    +G G GPV H H
Sbjct: 238 ANAYVHQGLIEAK--GIGRGPGPVAHTH 263


>UniRef50_Q11F75 Phosphomethylpyrimidine kinase n=3 Tax=Phyllobacteriaceae
           RepID=Q11F75_MESSB
          Length = 256

 Score =  209 bits (533), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 98/249 (39%), Positives = 144/249 (57%), Gaps = 3/249 (1%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R + L +AG+D SGGAG   D++  ++LG      ITA+ AQ    V +V  + P  V+A
Sbjct: 4   RPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q+++      ID  KIGML  +DIVEAV+  L+R+    VVLD V+ + SG  L+  + +
Sbjct: 64  QMEAALEAEPIDAIKIGMLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGI 123

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
           A L+  LLP   L+TPN  E A L     A +E+E L+QG  LLA GC A+L+KGGH  D
Sbjct: 124 AVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALDQGNLLLASGCHALLVKGGHAPD 183

Query: 183 EQ-SPDWLFTREGE-QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
           ++ S D L  R    +RF APR+ ++   GTGC L++++AA   R  +  +++   K  +
Sbjct: 184 KRNSTDILLRRGHAPERFEAPRLDSR-MRGTGCALASSIAAALARGLSLEESIAFGKRKV 242

Query: 241 SSALAQADT 249
              L +AD 
Sbjct: 243 YHLLREADA 251


>UniRef50_D0KR61 Phosphomethylpyrimidine kinase n=2 Tax=Sulfolobus solfataricus
           RepID=D0KR61_SULS9
          Length = 400

 Score =  209 bits (533), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 85/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           R    TIAG+D  GGAG+QADLKTFSALG +G ++IT L AQNTR V  V  I  DF+ A
Sbjct: 4   RPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEA 63

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q D+V  D+     K GMLA   +VE V  +++ Y    +VLD VM+AKSG  L++    
Sbjct: 64  QFDAVCLDLHPTHAKTGMLASGKVVELVLRKIREYN-IKLVLDPVMVAKSGSLLVTEDIS 122

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             ++   + +  + TPN  EA  + +     ++ ++++  R + +   G V++KG     
Sbjct: 123 EQIKKA-MKEAIISTPNRYEAEII-NKTKINSQDDVIKAAREIYSKY-GNVVVKGF---- 175

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
               D+      E       I TKNTHG+G   SA++ A         D +  AK + + 
Sbjct: 176 -NGVDYAIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATM 234

Query: 243 ALA 245
            + 
Sbjct: 235 TVK 237


>UniRef50_B0AAH1 Putative uncharacterized protein n=2 Tax=Clostridium
           RepID=B0AAH1_9CLOT
          Length = 284

 Score =  209 bits (532), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 50/269 (18%), Positives = 101/269 (37%), Gaps = 10/269 (3%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIE-PDFVA 61
                 I      G   +   +   SAL    C   TA+++  T G      ++    + 
Sbjct: 12  LKKVAAINDMSGIGKCSLTVAIPILSALKTQCCPYPTAILSSQT-GYPKFTYLDFTSHMQ 70

Query: 62  AQLDSVFS-DVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
               +    DV  DT   G L   D ++ V + ++      V++D VM            
Sbjct: 71  EYNRAWKELDVSFDTIYSGFLGSIDQIDIVRDFIKSNNNAYVIVDPVMGDGGDYYQTFND 130

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHAR--TEQEMLEQGRSLLAMGCGAVLMKGG 178
            +      L+    L+TPNL EA  L +  +    T +E L+  + + A+G   V++ G 
Sbjct: 131 EICNKIKDLVKISDLVTPNLTEACLLTNNKYHTNYTLEETLDLAKEISALGPKKVIITGI 190

Query: 179 HLDDEQSPDWLFTREGEQRFTAP-RIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAK 237
            L D    +  + +E ++  +   +   K+  GTG   ++ ++ L     ++ D+++ A 
Sbjct: 191 -LIDGNIINLGYDKENDEYLSYSLKYNNKSYSGTGDIFTSIISGLITNGHDFKDSIKIAS 249

Query: 238 SWLSSALAQADTLEVGHGIGPVHHFHAWW 266
            ++   +      ++    G    F   +
Sbjct: 250 DFIFKCIEYTSKYDIDPNDGV---FFEVF 275


>UniRef50_A6EM49 Phosphomethylpyrimidine kinase n=1 Tax=unidentified eubacterium
           SCB49 RepID=A6EM49_9BACT
          Length = 246

 Score =  208 bits (530), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 12/249 (4%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           KR   LTI G DPS GAG+ AD+KTF     YG +V TA   Q      +   I    + 
Sbjct: 4   KRPFVLTIGGFDPSAGAGVLADIKTFEQHKVYGMAVNTANTIQTEDAFFASEAIASTSII 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL  +  +      KIG L   +++  VAE  +      ++ D ++ A SG  L     
Sbjct: 64  KQLRVLTDNYCFKAVKIGWLPSLELINLVAEVFKETS-VKIIWDPILKATSGFDLSHN-- 120

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              L  +L   + +ITPN  EA  +            +   ++L      A+ +KGGH  
Sbjct: 121 REQLIEKL-KLIDIITPNWQEARVISGETEI------ISAMQTLSKQ--CAIYLKGGHNI 171

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
                D+LF  + +  +        + HG+GC  S+ALA+      +   +   +K + +
Sbjct: 172 QAPGRDFLFINQEKVNYKPQGSQVSDKHGSGCVFSSALASNLALGYSLKKSCLNSKQYTT 231

Query: 242 SALAQADTL 250
           + L    +L
Sbjct: 232 ALLESNTSL 240


>UniRef50_B5ERP1 Phosphomethylpyrimidine kinase n=2 Tax=Acidithiobacillus
           ferrooxidans RepID=B5ERP1_ACIF5
          Length = 277

 Score =  208 bits (530), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 89/252 (35%), Positives = 128/252 (50%), Gaps = 6/252 (2%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
               LTIAG+DPS GAG+QADL T ++LG +GC+ +TAL  Q++  V+    ++P    A
Sbjct: 12  LPVVLTIAGSDPSAGAGLQADLLTLASLGVHGCTAVTALTVQDSVNVRGYTPVDPQDTVA 71

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAV 122
           Q  +V  D+ +   KIGML    +V AV+  L  +    VVLD V+ A  G  L      
Sbjct: 72  QARAVLEDMSVQVIKIGMLGSAAMVAAVSALLADHSQIPVVLDPVLAAGGGMALAGDGLR 131

Query: 123 ATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182
             L +RLLP+V+++TPN PEA AL          ++   G  L   G    L+ GGH ++
Sbjct: 132 EALVTRLLPRVTVMTPNGPEALALSGTG------DLPAAGVWLNRHGAEWALISGGHGEE 185

Query: 183 EQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242
            +  + LF  E  +R      +  + HG+GCTL+AALAA         + V  A  +  +
Sbjct: 186 PELENLLFRGEVLRRTFRQARLPHSYHGSGCTLAAALAAGLAHGLTMEEAVARALDFTHA 245

Query: 243 ALAQADTLEVGH 254
            L  A  L  G 
Sbjct: 246 CLVHAYPLGKGQ 257


>UniRef50_A1S6Q8 Phosphomethylpyrimidine kinase., Thiamine-phosphate diphosphorylase
           n=2 Tax=Shewanella RepID=A1S6Q8_SHEAM
          Length = 525

 Score =  206 bits (526), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 93/279 (33%), Positives = 136/279 (48%), Gaps = 25/279 (8%)

Query: 3   RINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAA 62
           +    TIAG+D  GGAGIQADL T   LG YGCSVITA+ AQN+  V +V  + P  + A
Sbjct: 10  KPIVWTIAGSDSGGGAGIQADLLTLQDLGCYGCSVITAITAQNSVAVTAVEPVTPRMLRA 69

Query: 63  QLDSVFSDVRIDTTKIGMLAETDIVEAVAERL-QRYQIQNVVLDTVMLAKSGDPLLSPSA 121
           QL+++ +D+     KIG++A    ++ +A+ L +      V+LD VM+A  G  L SP  
Sbjct: 70  QLETLKADLYPSAVKIGLIANQPQLDFLADWLGENLPGVPVILDPVMVASCGGDLQSPDN 129

Query: 122 VATLRS------RLLPQV---SLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGA 172
               ++         P     SLITPN  E + L+       +  +      L     G+
Sbjct: 130 TCPDKTGERSGLDFSPFAGKISLITPNKAELSRLIG-RLLNDDDALEWAANVLWQAFGGS 188

Query: 173 VLMKGGHLDDEQ--SPDWLFTRE----------GEQRFTAPRIMTKNTHGTGCTLSAALA 220
           +L KGG    +Q  + D L   +               +  R+ T + HG+GCTLS+A+A
Sbjct: 189 ILAKGGDCPWQQSKARDLLLLGDIATISPLHRRQGFWLSNERVATVHNHGSGCTLSSAIA 248

Query: 221 ALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPV 259
           A   +     D V  AK+++   L QA    VG G GP+
Sbjct: 249 AFVAKGLVLPDAVLLAKAYVFEGLRQASA--VGSGPGPL 285


>UniRef50_A6DPJ2 Putative uncharacterized protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DPJ2_9BACT
          Length = 272

 Score =  206 bits (526), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 120/255 (47%), Gaps = 5/255 (1%)

Query: 2   KRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVA 61
           K    LTIAG D  G AG+QADL+ F+    +  SV++A  AQ+   V SV  +      
Sbjct: 4   KLNTCLTIAGADSGGEAGVQADLQVFNYFNCHALSVLSATTAQSYSRVLSVNPVGITAFE 63

Query: 62  AQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSA 121
            QL+ VFSD +    K GML + + +    E  ++     +V+D +M++ SG  LL  SA
Sbjct: 64  DQLEVVFSDFQPACIKTGMLVDGEYINVFLE--RKPSSAQLVVDPLMMSTSGTELLEKSA 121

Query: 122 VATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLD 181
              +R  L+P  +++TPN PE   LL        +EM+++   L+      V +KGGH  
Sbjct: 122 WGVMRDLLIPSANMVTPNFPELRFLLGIDEVMCGEEMVQRYFDLVQ---VPVYLKGGHNA 178

Query: 182 DEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
           +  S D+     G        +  K +HGTGC +S+AL A      +        K +L 
Sbjct: 179 EAPSIDFFIDESGLWSLKTDELEIKASHGTGCRVSSALTAGLSNGLSGLQAAINTKKYLH 238

Query: 242 SALAQADTLEVGHGI 256
            +L     L  G  +
Sbjct: 239 QSLKSYKALSDGQYV 253


>UniRef50_C6NTD4 Phosphomethylpyrimidine kinase n=1 Tax=Acidithiobacillus caldus
           ATCC 51756 RepID=C6NTD4_9GAMM
          Length = 267

 Score =  206 bits (526), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 74/231 (32%), Positives = 105/231 (45%), Gaps = 7/231 (3%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
              L+IA  DPS GAG+QADL T +ALG + C+ + A   Q++R V  V  +    +AAQ
Sbjct: 5   PLVLSIAAADPSSGAGLQADLLTGAALGVHVCTALAAWTIQDSRDVVRVTALPGTDLAAQ 64

Query: 64  LDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVA 123
           L  + +D      KIG+L   +    VA  L  +    VVLD ++ A  G  +       
Sbjct: 65  LQVLAADCSFSAVKIGLLGSAENARVVARFLDAHPKLPVVLDPILRAGGGRAVSDAELRG 124

Query: 124 TLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDE 183
            L   LLP+ ++ TPN PEA  L          E+    R LLA G   +L+ GGH  D 
Sbjct: 125 VLVDELLPRATVATPNAPEALQLSGC------DELEAAARRLLATGLAHLLISGGHGTDP 178

Query: 184 -QSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
            +     +  +G              HGTGCTL+ A+AA         + +
Sbjct: 179 RRIRSRHYRADGVLSCVEQPRRPGQFHGTGCTLATAIAAGLALGRAPDEAI 229


>UniRef50_B5IAY3 Phosphomethylpyrimidine kinase superfamily n=2 Tax=Aciduliprofundum
           boonei T469 RepID=B5IAY3_9EURY
          Length = 242

 Score =  206 bits (524), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 75/245 (30%), Positives = 120/245 (48%), Gaps = 13/245 (5%)

Query: 7   LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66
           L+IAG DP+ GAG+  D+ TF   G YG  V TAL  QNTRG +    + P+ V  +L +
Sbjct: 5   LSIAGFDPTSGAGVIRDIITFRKFGFYGLGVATALTYQNTRGFKGFKVLSPNVVEQELKA 64

Query: 67  VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLR 126
           +  D  I   K+GML  +  V+ + E  + +    ++ D ++ AK+G  +     +    
Sbjct: 65  IMGDFPIKFVKVGMLGTS--VDLIVEFAREHDW-FLIFDPLLTAKNGKTINKIEDI---- 117

Query: 127 SRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSP 186
             LL     ITPN+PEA  L      + E +++  G+ L       V++KGGHL+     
Sbjct: 118 EPLLKIAEAITPNVPEAEKLAGIK-IKNESDVISAGKILTHKYGKYVIIKGGHLNGR--- 173

Query: 187 DWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQ 246
           D+LF  +  + +  P+I  K  HGTGC  S++L +   +     +   EA+ +L   +  
Sbjct: 174 DYLF-GDEIKSYGMPKIN-KIVHGTGCAYSSSLLSFIAKGLKIEEAFIEARKFLQREIEN 231

Query: 247 ADTLE 251
           A    
Sbjct: 232 AIDTG 236


>UniRef50_C9Q178 Phosphomethylpyrimidine kinase n=1 Tax=Prevotella sp. oral taxon
           472 str. F0295 RepID=C9Q178_9BACT
          Length = 368

 Score =  206 bits (524), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 76/241 (31%), Positives = 128/241 (53%), Gaps = 5/241 (2%)

Query: 6   ALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLD 65
            LTI G+D +GGAGIQAD+KT SALG    S IT++ AQNT G+Q  + +  + V  Q++
Sbjct: 8   ILTINGSDGTGGAGIQADIKTISALGGRALSAITSITAQNTLGIQEFFDLPSETVKGQIE 67

Query: 66  SVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATL 125
           ++ +D++    K+GM+   D V  +A  L++++ ++V+ D V+++   + L++   +  +
Sbjct: 68  AIVNDIQPTVVKVGMIRRADTVAQIAHLLRQHKPKHVIYDPVIVSSQNEMLMAQEVIDEV 127

Query: 126 RSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQS 185
           R  LLP  SL+     +A  L       T  ++    +SLLA GC AVL++G H   +  
Sbjct: 128 RRSLLPLCSLVLMKRADAERLTQTA-INTAADLNLAVKSLLAGGCQAVLLQGSHTPPQSL 186

Query: 186 PDWLFT-REGEQRFTAPRI---MTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241
            D   T ++GE  F             HG   +LSAA+A          + V  A+++++
Sbjct: 187 TDVFATAKDGEPTFLPSLFGEGEGNTRHGLSGSLSAAIATFVNGGNAIFEAVVNARNYIA 246

Query: 242 S 242
            
Sbjct: 247 Q 247


>UniRef50_O83153 Putative pyridoxine kinase n=4 Tax=Bacteria RepID=PDXK_TREPA
          Length = 269

 Score =  205 bits (523), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 77/243 (31%), Positives = 117/243 (48%), Gaps = 6/243 (2%)

Query: 20  IQADLKTFSALGAYGCSVITALVAQNTRGVQS--VYRIEPDFVAAQLDSVFSDVRIDTTK 77
           I+ADLKTF   GA+G + +TA+V  +     S  V+ +E D V  QL++ F+ V +   K
Sbjct: 18  IEADLKTFQEYGAFGVATLTAIVTMDPSRNWSHRVHSLEEDCVRDQLETAFAGVGVSAVK 77

Query: 78  IGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLIT 137
            GMLA    +E VAE L+R+ +   V D VM+ K     L       +  +LLP+ +++T
Sbjct: 78  SGMLASVHAIECVAEYLERFAVAAYVFDPVMVCKGSGDALHRELNELMIQKLLPRATVVT 137

Query: 138 PNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD--EQSPDWLFTREGE 195
           PNL E A +      RT  EM E  R +   G   V +KGG      + + D  +  +  
Sbjct: 138 PNLFETAQIAGISVPRTVDEMKEGARLIHERGASHVFVKGGGRLPGCKHALDVFYDGKTF 197

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLE--VG 253
                  + +   HG GCT+SAA+ A   R     D +  AK ++++ L     +   VG
Sbjct: 198 HLVEDELVQSGWNHGAGCTVSAAITAGLGRGLTAYDAILSAKRFVTTGLRHGFQVNQWVG 257

Query: 254 HGI 256
            G 
Sbjct: 258 TGN 260


>UniRef50_C9XPL6 Putative pyridoxine kinase n=6 Tax=Clostridium RepID=C9XPL6_CLODC
          Length = 273

 Score =  205 bits (523), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 50/263 (19%), Positives = 98/263 (37%), Gaps = 9/263 (3%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIE-PDF 59
           M++     I      G   +   +   SAL    C   TA+++  T G      ++  D 
Sbjct: 1   MQK-KVAAINDLSGIGKCSLSVAIPILSALKVQCCPFPTAILSSQT-GYPEFTFLDFTDE 58

Query: 60  VAAQLDSVFSD-VRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLS 118
           +    +   +  V  D+   G L     +E VA  +  Y    +V+D VM        + 
Sbjct: 59  MVKYSNVWKNLKVNFDSIYSGFLGSKHQIEIVANFINDYPNAFIVVDPVMGDNGVMYPIF 118

Query: 119 PSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTE---QEMLEQGRSLLAMGCGAVLM 175
              +      L+    L TPNL EA  L    + +++    E++   +S+  +G   V++
Sbjct: 119 TEEMRQEIKELVKHSDLTTPNLTEACFLTGNDYTKSDYNRDELIYIAKSVSDLGPSKVVI 178

Query: 176 KGGHLDDEQSPDWLFTREGEQ-RFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQ 234
            G  L+D+   +  + R+ +   FT+ +    +  GTG   ++ L  +     +    V 
Sbjct: 179 TGI-LEDDNILNLAYDRDNDHVFFTSVKYNNCSYSGTGDIFTSILCGMLVNKHDLGVAVN 237

Query: 235 EAKSWLSSALAQADTLEVGHGIG 257
            A  ++   +      +     G
Sbjct: 238 TATDFIYKTINYTSQFDTDRNDG 260


>UniRef50_A1TYG7 Phosphomethylpyrimidine kinase n=3 Tax=Marinobacter
           RepID=A1TYG7_MARAV
          Length = 253

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 80/249 (32%), Positives = 128/249 (51%), Gaps = 7/249 (2%)

Query: 9   IAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVF 68
           ++G DPSGGAGIQAD++  +++GA+   V+T L  Q+TR V     + PD +  QL+ + 
Sbjct: 2   LSGLDPSGGAGIQADIQAITSIGAHPLPVLTCLTVQDTRNVYGAEPVSPDLIKQQLECLA 61

Query: 69  SDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSR 128
            D  I   K G L   ++VE + E +Q++    +++D V+ A  G  L   + VA ++ +
Sbjct: 62  QDTPIHAIKTGALGNAEVVEVLVEFVQKHSGVPLIVDPVIKAAGGGDLADDALVAAMKDK 121

Query: 129 LLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDW 188
           L  +  +ITPN  E A L  +          E  R+LL  GC +VL  GGH       + 
Sbjct: 122 LFARAEMITPNGVELAQLGGS------DNPAEAARNLLQTGCESVLATGGHGSGIHIINT 175

Query: 189 LFTRE-GEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQA 247
           L+        +   R+     HGTGCTL+AA+AA R    +    + +A++++  AL  A
Sbjct: 176 LYNHAPEPMEWEVERVGANEYHGTGCTLAAAIAAGRAMGLSPRAAISQAQNYVHRALLHA 235

Query: 248 DTLEVGHGI 256
            T+  G  +
Sbjct: 236 LTVGQGQKV 244


>UniRef50_B1MZ30 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase n=3
           Tax=Leuconostoc RepID=B1MZ30_LEUCK
          Length = 268

 Score =  205 bits (522), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 81/251 (32%), Positives = 123/251 (49%), Gaps = 6/251 (2%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
             LTIAG+D   G GIQADL TFS  G +G +V TA+V   T+  Q V+ I P  +A QL
Sbjct: 4   KILTIAGSDSLSGGGIQADLATFSEYGYFGLAVTTAIVTVTTKDFQ-VFPIAPHIIAEQL 62

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVAT 124
           +SV +   I   KIG L     +E VAE LQ  +   +++D VM  K    + +      
Sbjct: 63  NSVLALDDIRAIKIGFLPTVASIEIVAEHLQHIKNIPIIVDPVMAFKETQIVDTHFLAKV 122

Query: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGG-HLDDE 183
           L  ++LP  +++TPNL EA  L          +M    + +  +G   V++KGG  +   
Sbjct: 123 LTEKILPFATILTPNLKEAEILSG-HDISDVNDMRNAAKEIFQLGPTYVVIKGGSQILGN 181

Query: 184 QSPDWLFTREGEQRFTAPRI-MTKNTH-GTGCTLSAALAALRPRHT-NWADTVQEAKSWL 240
           Q+ D L+       F   +I  ++  H G GC+LSA+LAA   ++       + +AK ++
Sbjct: 182 QAVDVLYDGHQFSLFKQDKIVRSQPYHSGAGCSLSASLAANLSQNNVTVNLALSDAKDFV 241

Query: 241 SSALAQADTLE 251
              +     L 
Sbjct: 242 WQGIKHGVKLN 252


>UniRef50_A1R2R6 Kinase, pfkB family n=27 Tax=Actinomycetales RepID=A1R2R6_ARTAT
          Length = 298

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 73/253 (28%), Positives = 124/253 (49%), Gaps = 12/253 (4%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGV--QSVYRIEPDFVAA 62
            ALTIAG++ +GGAG QADLKTF  LG +G + +T +V+ N +         ++   +A 
Sbjct: 29  IALTIAGSEATGGAGAQADLKTFQELGVFGIANLTCIVSFNPQDNWNHRFVPVDQQVIAD 88

Query: 63  QLDSVFSDVR--------IDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGD 114
           QL++  +           +DT KIGML     +  V + L      NVVLD V++ K  +
Sbjct: 89  QLEATTAAYGAASGAPSVLDTVKIGMLGSPATISTVEKALTDGDFANVVLDPVLICKGQE 148

Query: 115 PLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVL 174
           P  +      L++++LP  + +TPN  EA +L        E+ +      +  +   AVL
Sbjct: 149 PGHALDTDQALKAQILPLATFVTPNHFEAESLSGLT-ISDEESLKAAAIRIHEISGAAVL 207

Query: 175 MKGG-HLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
            KGG  L+   + D  +  E  +   AP++      G GC+L+AA+ A   +     +  
Sbjct: 208 AKGGVRLEGPDAVDVYYDGETLEVLRAPKVGEVAVSGAGCSLAAAVTAELAKGATPLEAA 267

Query: 234 QEAKSWLSSALAQ 246
           + AK+++++ +  
Sbjct: 268 RTAKAFVTAGIKN 280


>UniRef50_A1VFK1 Phosphomethylpyrimidine kinase type-1 n=30 Tax=Bacteria
           RepID=A1VFK1_DESVV
          Length = 303

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 49/264 (18%), Positives = 95/264 (35%), Gaps = 11/264 (4%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIE-PDFVAA 62
                I      G   +   +   SA+G   C + TA+++ +T G +    I+    +  
Sbjct: 17  PRVAAIHDLSGFGRTSLTVAIPVLSAMGIQVCPMPTAMLSTHTSGFKGFSFIDLTAEMRR 76

Query: 63  QLDSVFS-DVRIDTTKIGMLAETDIVEAVAERLQRY--QIQNVVLDTVMLAKSGDPLLSP 119
             D   S ++R D    G L   D V  VA+ +  +       V+D V+           
Sbjct: 77  FFDHWKSLNIRFDAIYSGFLGSPDQVAIVAQCIDMFRTPDGFAVVDPVLGDNGELEPTMD 136

Query: 120 SAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQE--MLEQGRSLLAMGCGAVLMKG 177
             +      L+ +  +ITPN  EAA LLD P+     +  + +  R L AMG    ++  
Sbjct: 137 MEMVHRMRWLVSKADIITPNFTEAALLLDEPYREHIDQPTLKDWLRRLTAMGPHVAVVTS 196

Query: 178 GHLDDEQSPDWLFT----REGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTV 233
             ++  ++   +       +   +     I   +  GTG T ++ L     +  +    +
Sbjct: 197 VPVEGSRTTTSVVAYNRPHDRFWKVDCQYI-PAHYPGTGDTFASVLTGSILQGDSLPIAI 255

Query: 234 QEAKSWLSSALAQADTLEVGHGIG 257
           + A  +++  +            G
Sbjct: 256 ERAVQFVTMGIRATFGHNSPSREG 279


>UniRef50_A4NVQ6 Phosphomethylpyrimidine kinase n=2 Tax=Haemophilus influenzae
           RepID=A4NVQ6_HAEIN
          Length = 189

 Score =  204 bits (519), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 68/188 (36%), Positives = 98/188 (52%), Gaps = 7/188 (3%)

Query: 80  MLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPN 139
           ML   +I+E VA+ L       +VLD VM+AK G PLL   AV+ L  +LLP   +ITPN
Sbjct: 1   MLGNAEIIECVADFLADKPFGALVLDPVMIAKGGAPLLQQQAVSALSQKLLPLADVITPN 60

Query: 140 LPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH---LDDEQSPDWLFTREG-E 195
           +PEA AL           + +  ++L   G   V++KGGH      E   DW+   +G  
Sbjct: 61  IPEAEALTGIAIVDDI-SIQQAAKALQKQGAKNVIIKGGHSLNSQSELCQDWVLLADGRH 119

Query: 196 QRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHG 255
               +PR  T +THGTGCT SA L A   +       V+ AK ++++A++    L +G G
Sbjct: 120 FTLQSPRFNTPHTHGTGCTFSACLTAELAKGEPLQSAVKTAKDFITAAISH--PLNIGQG 177

Query: 256 IGPVHHFH 263
            GP +H+ 
Sbjct: 178 QGPTNHWA 185


>UniRef50_Q30XQ8 Pyridoxal kinase, putative n=24 Tax=Bacteria RepID=Q30XQ8_DESDG
          Length = 300

 Score =  203 bits (518), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 51/267 (19%), Positives = 104/267 (38%), Gaps = 17/267 (6%)

Query: 4   INALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQ 63
                I      G   +   +   S++G   C + TA+++ +T G ++   ++   +  Q
Sbjct: 6   PRVAAIHDLSGFGRTSLTVAMPVLSSMGVQVCPLPTAVLSTHTSGFENFSFVD---LTEQ 62

Query: 64  LDSVFSDVR-----IDTTKIGMLAETDIVEAVAERLQRY--QIQNVVLDTVMLAKSG-DP 115
           + S+    +      D    G L   + V+ VA  +  +       V+D VM      +P
Sbjct: 63  MHSILDHWQSLNLKFDAVYSGFLGSPEQVDIVARCIDMFRTPDGLAVVDPVMGDNGEMEP 122

Query: 116 LLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPH--ARTEQEMLEQGRSLLAMGCGAV 173
            ++   V  +R  L+ +  +ITPN  EAA LLD  +    T   + +  R L AMG    
Sbjct: 123 TMTLEMVHRMR-WLVTKADIITPNFTEAAFLLDEKYTTEATVSTVKDWLRRLTAMGPSIA 181

Query: 174 LMKG--GHLDDEQSPDWLFTREGEQRFTAP-RIMTKNTHGTGCTLSAALAALRPRHTNWA 230
           ++     H D+ +S    + R  ++ +      +  +  GTG T ++ +     +  +  
Sbjct: 182 IITSVPVHGDERRSAVMAYNRRHDRFWKVDCSYIPAHYPGTGDTFASVVTGALLQGDSLP 241

Query: 231 DTVQEAKSWLSSALAQADTLEVGHGIG 257
             +  A  +++  +       +    G
Sbjct: 242 IAMDRAVQFVTMGIRATFGHNLPSRDG 268


>UniRef50_B1ID10 Phosphomethylpyrimidine kinase n=63 Tax=Streptococcus
           RepID=B1ID10_STRPI
          Length = 257

 Score =  203 bits (518), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 75/253 (29%), Positives = 123/253 (48%), Gaps = 6/253 (2%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    L ++G D   G G+ ADL T++  G +G   +T L A   +G   V+  +    
Sbjct: 1   MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTALTEKGF-EVFPTDDTIF 59

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
             +LDS+  DV     KIG+L    + E   + +++     VVLD V++ K    +    
Sbjct: 60  QHELDSLR-DVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPVVLDPVLVCKETHDVAVSE 118

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGH- 179
               L  R  P VS+ITPNLPEA  L      +T ++M    + L  +G  AV++KGG+ 
Sbjct: 119 LCQELI-RFFPYVSVITPNLPEAELLSG-QEIKTLEDMKTAAQKLHDLGAPAVIIKGGNR 176

Query: 180 LDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSW 239
           L  +++ D  +  +       P I  +N  G GCT ++++A+   +       V+ +K++
Sbjct: 177 LSQDKAVDVFYDGQTFTILENPVIQGQNA-GAGCTFASSIASHLIKGDKLLPAVESSKAF 235

Query: 240 LSSALAQADTLEV 252
           +  A+AQAD   V
Sbjct: 236 VYRAIAQADQYGV 248


>UniRef50_B3L660 Phosphomethylpyrimidine kinase, putative n=3 Tax=Plasmodium
           RepID=B3L660_PLAKH
          Length = 329

 Score =  203 bits (517), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 85/306 (27%), Positives = 135/306 (44%), Gaps = 48/306 (15%)

Query: 5   NALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQL 64
           N L+IAG+D  GGAGIQAD+KT   LG + C+ +  L AQNT+ V+ +  IE  F+  QL
Sbjct: 6   NILSIAGSDSCGGAGIQADIKTAMGLGCHCCTALVVLTAQNTKEVKRIVEIEEAFIVDQL 65

Query: 65  DSVFSDVRIDTTKIGMLAETDIVEAVAERL-----QRYQIQNVVLDTVMLAKSGDPLLSP 119
           DS+F+DV ID  K+G+L    I+  V++ +     +R +   VV D V ++ SG  L+  
Sbjct: 66  DSIFADVTIDVVKLGVLYSKKIISLVSQYIVQMNKKRGKKLLVVFDPVFVSSSGCLLVEN 125

Query: 120 -SAVATLRSRLLPQVSLITPNLPEAAAL---LDAPHARTEQEMLEQGRSLLAM-GCGAVL 174
              +      + P   +ITPN  E   +   LD     ++  M E  + +  M    A L
Sbjct: 126 LEYIKFALDLICPISCIITPNFYECKVILQALDCQMDLSKANMTELCKLVTRMLDINACL 185

Query: 175 MKGGHLDDE-------QSPDWLFTRE-----------------------------GEQRF 198
           +K  ++ +         + D L  R+                                + 
Sbjct: 186 LKSCNVGENSAEENEVYAVDHLCIRKVGSIPEGEVIQRDAGELGQSAPGGVTYLYDVYKL 245

Query: 199 TAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGP 258
            + R    + HGTGCTLS A+A    +  N   +  E+K ++ + +  A     G     
Sbjct: 246 RSKRKPGVDVHGTGCTLSTAIACYLAKKHNILQSCIESKKYIYNCIRYA--YPFGSKSQG 303

Query: 259 VHHFHA 264
           ++H  A
Sbjct: 304 LNHLKA 309


>UniRef50_B4U544 Phosphomethylpyrimidine kinase n=3 Tax=Streptococcus equi
           RepID=B4U544_STREM
          Length = 249

 Score =  203 bits (517), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 79/252 (31%), Positives = 127/252 (50%), Gaps = 5/252 (1%)

Query: 1   MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFV 60
           MK    LTIAG+D   G G+QADL     L ++    IT L + + +G  S++ +  D +
Sbjct: 1   MKN-KVLTIAGSDIFSGGGLQADLAVLHQLDSFAFLAITCLTSCDAKGF-SIHPVATDLL 58

Query: 61  AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPS 120
           A QL S+ + +     K+G+L   +I E VA  L+  +   VVLD V++ K         
Sbjct: 59  AKQLSSLAA-IPFQAIKVGLLPRPEIAEQVALFLELKKDIPVVLDPVLVFKENQDQTVVE 117

Query: 121 AVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHL 180
               LRS L P  ++ITPNL EA  L       + ++M+E  + L  MG   V++KGG+ 
Sbjct: 118 MTQALRS-LFPLTAVITPNLREAERLAGLA-INSREQMVEAAKKLYEMGAKRVVIKGGNR 175

Query: 181 DDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWL 240
            D++    LF       F    ++ +  +G GC+ +AA+AA   R  +    V++AK  +
Sbjct: 176 FDQRVALDLFYDAKTLCFLEKPVLARQNNGAGCSFAAAIAAYLARGHSPFRAVEQAKDLV 235

Query: 241 SSALAQADTLEV 252
            +A+ Q++   V
Sbjct: 236 FAAIQQSNDYGV 247


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.314    0.173    0.524 

Lambda     K      H
   0.267   0.0529    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,931,410,895
Number of Sequences: 3077464
Number of extensions: 96495637
Number of successful extensions: 289765
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 1861
Number of HSP's successfully gapped in prelim test: 2768
Number of HSP's that attempted gapping in prelim test: 281282
Number of HSP's gapped (non-prelim): 4990
length of query: 266
length of database: 1,040,396,356
effective HSP length: 126
effective length of query: 140
effective length of database: 652,635,892
effective search space: 91369024880
effective search space used: 91369024880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 93 (40.1 bits)
